Guide to the Human Genome
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Search of human proteins with 241896935

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|241896935 WD repeat domain 25 [Homo sapiens]
         (544 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|241896935 WD repeat domain 25 [Homo sapiens]                      1131   0.0  
gi|241896933 WD repeat domain 25 [Homo sapiens]                      1131   0.0  
gi|7706657 cell division cycle 40 homolog [Homo sapiens]              149   8e-36
gi|16554629 WD repeat domain 5 [Homo sapiens]                         109   6e-24
gi|16554627 WD repeat domain 5 [Homo sapiens]                         109   6e-24
gi|23199987 WD repeat domain 5B [Homo sapiens]                         94   2e-19
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ...    70   6e-12
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s...    70   6e-12
gi|113865883 WD repeat domain 38 [Homo sapiens]                        69   8e-12
gi|32189425 WD repeat domain 69 [Homo sapiens]                         69   1e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    68   2e-11
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    64   4e-10
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    62   1e-09
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    62   1e-09
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    62   1e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    60   4e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    60   4e-09
gi|18874090 WD repeat domain 48 [Homo sapiens]                         60   5e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             59   1e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             59   1e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             59   1e-08
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    59   1e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     59   1e-08
gi|134133292 WD repeat domain 27 [Homo sapiens]                        57   6e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     56   7e-08
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      56   1e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          56   1e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          56   1e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          56   1e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            56   1e-07

>gi|241896935 WD repeat domain 25 [Homo sapiens]
          Length = 544

 Score = 1131 bits (2926), Expect = 0.0
 Identities = 544/544 (100%), Positives = 544/544 (100%)

Query: 1   MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60
           MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA
Sbjct: 1   MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60

Query: 61  GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120
           GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS
Sbjct: 61  GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120

Query: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180
           HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR
Sbjct: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180

Query: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240
           LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF
Sbjct: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240

Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300
           HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW
Sbjct: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300

Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
           APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA
Sbjct: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN
Sbjct: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
           QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE
Sbjct: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540
           CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM
Sbjct: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540

Query: 541 KIWH 544
           KIWH
Sbjct: 541 KIWH 544


>gi|241896933 WD repeat domain 25 [Homo sapiens]
          Length = 544

 Score = 1131 bits (2926), Expect = 0.0
 Identities = 544/544 (100%), Positives = 544/544 (100%)

Query: 1   MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60
           MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA
Sbjct: 1   MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60

Query: 61  GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120
           GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS
Sbjct: 61  GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120

Query: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180
           HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR
Sbjct: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180

Query: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240
           LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF
Sbjct: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240

Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300
           HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW
Sbjct: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300

Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
           APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA
Sbjct: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN
Sbjct: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
           QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE
Sbjct: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540
           CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM
Sbjct: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540

Query: 541 KIWH 544
           KIWH
Sbjct: 541 KIWH 544


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score =  149 bits (375), Expect = 8e-36
 Identities = 83/313 (26%), Positives = 159/313 (50%), Gaps = 13/313 (4%)

Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293
           +P+K +    GH   V+ ++  P+    H+LLS SMD   K+W       CL+T+  H++
Sbjct: 276 LPKKQIHVWSGHTKGVSAVRLFPL--SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK 333

Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT-TLKFHPKD--HNIFL 350
           AVR   +   G + LS  +D  L L D ETG Q  S  ++ ++   +KF+P +   N+F+
Sbjct: 334 AVRDICFNTAGTQFLSAAYDRYLKLWDTETG-QCISRFTNRKVPYCVKFNPDEDKQNLFV 392

Query: 351 CGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAW 410
            G    ++  WDIR+G++++ Y   +     I+F+ E   F+S++D       D+++  W
Sbjct: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD-------DKSLRVW 445

Query: 411 DFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGH 470
           ++               + P++ L P       Q+  N + +F     +R+++++ ++GH
Sbjct: 446 EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505

Query: 471 KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV 530
            V GY+   + SP    +++G  +G++ ++ ++T       + H + C+G  +HP   S 
Sbjct: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565

Query: 531 LATCSWGGDMKIW 543
           + TC W G +K+W
Sbjct: 566 VITCGWDGLIKLW 578


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  109 bits (273), Expect = 6e-24
 Identities = 86/310 (27%), Positives = 139/310 (44%), Gaps = 24/310 (7%)

Query: 240 FHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAAR 299
           F L GH   V+++++ P       L S+S DK  K+W A D G   +T S H   +    
Sbjct: 39  FTLAGHTKAVSSVKFSP---NGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94

Query: 300 WAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSE 357
           W+     ++S   D  L + D+ +G  L    G S++ +    F+P+  N+ + G F   
Sbjct: 95  WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY-VFCCNFNPQS-NLIVSGSFDES 152

Query: 358 MKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK 417
           ++ WD++TGK +++  A       + F R+GS  +SS       S D     WD  +   
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-------SYDGLCRIWDTASGQC 205

Query: 418 ISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYS 476
           +   I  +      +   P     LA T  N L L    W Y   +  + Y GHK E Y 
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL----WDYSKGKCLKTYTGHKNEKYC 261

Query: 477 VGCECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535
           +    S  GG  +V+GS D  V +++ +T      LQGHT   + T  HP   +++A+ +
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT-ENIIASAA 320

Query: 536 WGGD--MKIW 543
              D  +K+W
Sbjct: 321 LENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  109 bits (273), Expect = 6e-24
 Identities = 86/310 (27%), Positives = 139/310 (44%), Gaps = 24/310 (7%)

Query: 240 FHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAAR 299
           F L GH   V+++++ P       L S+S DK  K+W A D G   +T S H   +    
Sbjct: 39  FTLAGHTKAVSSVKFSP---NGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94

Query: 300 WAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSE 357
           W+     ++S   D  L + D+ +G  L    G S++ +    F+P+  N+ + G F   
Sbjct: 95  WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY-VFCCNFNPQS-NLIVSGSFDES 152

Query: 358 MKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK 417
           ++ WD++TGK +++  A       + F R+GS  +SS       S D     WD  +   
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-------SYDGLCRIWDTASGQC 205

Query: 418 ISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYS 476
           +   I  +      +   P     LA T  N L L    W Y   +  + Y GHK E Y 
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL----WDYSKGKCLKTYTGHKNEKYC 261

Query: 477 VGCECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535
           +    S  GG  +V+GS D  V +++ +T      LQGHT   + T  HP   +++A+ +
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT-ENIIASAA 320

Query: 536 WGGD--MKIW 543
              D  +K+W
Sbjct: 321 LENDKTIKLW 330


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 79/308 (25%), Positives = 130/308 (42%), Gaps = 24/308 (7%)

Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301
           L GH   V+++++ P       L S+S D+   +W A D  +    Y  H   +    W+
Sbjct: 37  LVGHTEAVSSVKFSP---NGEWLASSSADRLIIIWGAYDGKYEKTLYG-HNLEISDVAWS 92

Query: 302 PCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSEMK 359
               R++S   D  L L D+ +G  L    G S++ +    F+P   N+ + G F   +K
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY-VFCCNFNPPS-NLIISGSFDETVK 150

Query: 360 AWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKIS 419
            W+++TGK +++  A       + F   GS  +S        S D     WD  +   + 
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG-------SYDGLCRIWDAASGQCLK 203

Query: 420 NQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYSVG 478
             +  +      +   P     L  T  N L L    W Y   R  + Y GHK E Y + 
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL----WDYSRGRCLKTYTGHKNEKYCIF 259

Query: 479 CECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWG 537
              S  GG  +V+GS D  V +++ +T      LQGHT   +    HP   +++A+ +  
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT-ENLIASAALE 318

Query: 538 GD--MKIW 543
            D  +K+W
Sbjct: 319 NDKTIKLW 326


>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 80/324 (24%), Positives = 132/324 (40%), Gaps = 47/324 (14%)

Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293
           +P+K L  L   +G V  +++       +  L+   DKT K+WN +  G  L+TYS H  
Sbjct: 13  LPQKRLKTLDCGQGAVRAVRFNV---DGNYCLTCGSDKTLKLWNPL-RGTLLRTYSGHGY 68

Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLC 351
            V  A  +     + SGG D A+ L D+ +G   + F G +  ++ T++F+ ++  + L 
Sbjct: 69  EVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG-KVNTVQFN-EEATVILS 126

Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRD----SADRTI 407
           G   S ++ WD       RS +    QTLD     E  + +SS   S  +    S D  +
Sbjct: 127 GSIDSSIRCWD------CRSRRPEPVQTLD-----EARDGVSSVKVSDHEILAGSVDGRV 175

Query: 408 IAWDFRTSAKISNQI--------FHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPY 459
             +D R     S+ +        F     C  ++        L +  G  L         
Sbjct: 176 RRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLG-------- 227

Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACV 519
                  Y+GHK + Y + C  S     +V+ S DG+V  +     + A  L   +    
Sbjct: 228 ------EYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQ 281

Query: 520 GTTYHPVLPSVLATCSWGGDMKIW 543
              YHP  P +L   + GG ++ W
Sbjct: 282 SLAYHPTEPCLLT--AMGGSVQCW 303


>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 80/324 (24%), Positives = 132/324 (40%), Gaps = 47/324 (14%)

Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293
           +P+K L  L   +G V  +++       +  L+   DKT K+WN +  G  L+TYS H  
Sbjct: 13  LPQKRLKTLDCGQGAVRAVRFNV---DGNYCLTCGSDKTLKLWNPL-RGTLLRTYSGHGY 68

Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLC 351
            V  A  +     + SGG D A+ L D+ +G   + F G +  ++ T++F+ ++  + L 
Sbjct: 69  EVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG-KVNTVQFN-EEATVILS 126

Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRD----SADRTI 407
           G   S ++ WD       RS +    QTLD     E  + +SS   S  +    S D  +
Sbjct: 127 GSIDSSIRCWD------CRSRRPEPVQTLD-----EARDGVSSVKVSDHEILAGSVDGRV 175

Query: 408 IAWDFRTSAKISNQI--------FHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPY 459
             +D R     S+ +        F     C  ++        L +  G  L         
Sbjct: 176 RRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLG-------- 227

Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACV 519
                  Y+GHK + Y + C  S     +V+ S DG+V  +     + A  L   +    
Sbjct: 228 ------EYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQ 281

Query: 520 GTTYHPVLPSVLATCSWGGDMKIW 543
              YHP  P +L   + GG ++ W
Sbjct: 282 SLAYHPTEPCLLT--AMGGSVQCW 303


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 21/261 (8%)

Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296
           ++L+ L GH GPV   ++ P     H+  S S D T ++W+ V    CL+    H  +V 
Sbjct: 54  QLLWRLGGHTGPVKFCRFSP---DGHLFASASCDCTVRLWD-VARAKCLRVLKGHQRSVE 109

Query: 297 AARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLCGGF 354
              ++P  R++ SGG+D  + L D+++G   +L  G  D  I +  F P   N    G +
Sbjct: 110 TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD-SIQSSDFSP-TVNCLATGSW 167

Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRT 414
            S +  WD+R      S++A    + +I  L       S++      S D+TI  W   T
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCL-----CYSASGLLASGSWDKTIHIWKPTT 222

Query: 415 SAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVE 473
           S+ +     H  +   S+A  P E ++LA    + +     VW     +     +G  V 
Sbjct: 223 SSLLIQLKGHVTWV-KSIAFSPDE-LWLASAGYSRMV---KVWDCNTGKCLETLKG--VL 275

Query: 474 GYSVGCECSPGGDLLVTGSAD 494
             +  C  +P G +LV+G+AD
Sbjct: 276 DVAHTCAFTPDGKILVSGAAD 296



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 73/323 (22%), Positives = 119/323 (36%), Gaps = 67/323 (20%)

Query: 225 LNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHC 284
           +NS    T   R+V F  + H G VN+  + P      MLL+ S D     W    SG  
Sbjct: 1   MNSGVPATLAVRRVKFFGQ-HGGEVNSSAFSP---DGQMLLTGSEDGCVYGWET-RSGQL 55

Query: 285 LQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFR-ITTLKFHP 343
           L     HT  V+  R++P G    S   D  + L D+     L   +   R + T+ F P
Sbjct: 56  LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP 115

Query: 344 KDHNIFLCGGFSSEMKAWDIRTGKVMR---SYKATIQQTLDILFLREGSEFLSSTDASTR 400
            D      GG+   +  WD+++G+++R    ++ +IQ           S+F  + +    
Sbjct: 116 -DSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS----------SDFSPTVNCLAT 164

Query: 401 DSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYR 460
            S D T+  WD R    ++  + H+                                   
Sbjct: 165 GSWDSTVHIWDLRM---VTPAVSHQAL--------------------------------- 188

Query: 461 MSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVG 520
                  EGH     ++ C C     LL +GS D  + ++   T+S    L+GH      
Sbjct: 189 -------EGHSA---NISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238

Query: 521 TTYHPVLPSVLATCSWGGDMKIW 543
             + P     LA+  +   +K+W
Sbjct: 239 IAFSPD-ELWLASAGYSRMVKVW 260



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 50/214 (23%), Positives = 81/214 (37%), Gaps = 48/214 (22%)

Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296
           K L  L+GH+  V T+ + P    S  L S   DK   +W+ V SG  L+    H ++++
Sbjct: 96  KCLRVLKGHQRSVETVSFSP---DSRQLASGGWDKRVMLWD-VQSGQMLRLLVGHRDSIQ 151

Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQ------------------------LFSGRS 332
           ++ ++P    + +G +D  +H+ DL   T                         L SG  
Sbjct: 152 SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSW 211

Query: 333 DFRI-------TTLKFHPKDHNIFL-------------CGGFSSEMKAWDIRTGKVMRSY 372
           D  I       ++L    K H  ++               G+S  +K WD  TGK + + 
Sbjct: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271

Query: 373 KATIQQTLDILFLREGSEFLSSTDASTRDSADRT 406
           K  +       F  +G   +S     TR    RT
Sbjct: 272 KGVLDVAHTCAFTPDGKILVSGAADQTRRQISRT 305


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 19/303 (6%)

Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301
           L GHR  V  I +         + + S DKT K+W+ V++G C  T+  HT  +    + 
Sbjct: 130 LEGHRNVVYAIAFNNPYGDK--IATGSFDKTCKLWS-VETGKCYHTFRGHTAEIVCLSFN 186

Query: 302 PCGRRILSGGFDFALHLTDLETGTQLFSGRS-DFRITTLKFHPKDHNIFLCGGFSSEMKA 360
           P    + +G  D    L D++ G ++++ R     I +L F+     I + G F   +  
Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVV 245

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           WD  TG+ +        +     F  + S  L+        S D+T   WD      ++ 
Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTG-------SMDKTCKLWDATNGKCVAT 298

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
              H+     S   +  + +  A  +G    +FS      ++   + EGH  EG      
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGT-ARIFSAATRKCIA---KLEGH--EGEISKIS 352

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540
            +P G+ L+TGS+D    ++  +T      L+GHT       ++    +++ T S     
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTC 411

Query: 541 KIW 543
           +IW
Sbjct: 412 RIW 414


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 65/295 (22%), Positives = 116/295 (39%), Gaps = 53/295 (17%)

Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301
           L+GH G V  + +    +   ML S S DKT  VW++ ++G  ++    HT  V +   A
Sbjct: 105 LKGHSGAVMELHYN---TDGSMLFSASTDKTVAVWDS-ETGERVKRLKGHTSFVNSCYPA 160

Query: 302 PCGRRIL-SGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
             G +++ +G  D  + L D+     + + ++ +++  + F+     I + GG  +++K 
Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQI-ISGGIDNDIKV 219

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           WD+R  K+  + +        +    EGS  LS+       + D T+  WD R  A    
Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN-------AMDNTVRVWDVRPFA---- 268

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
                          P+E                     R  +  +   H  E   + C 
Sbjct: 269 ---------------PKE---------------------RCVKIFQGNVHNFEKNLLRCS 292

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535
            SP G  +  GSAD  V ++   +      L GH  +     +HP  P +++  S
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 55/222 (24%), Positives = 89/222 (40%), Gaps = 24/222 (10%)

Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296
           ++L  L+GH   V ++ + P      ++ S S D T ++W+ V +  C+Q    H  AV 
Sbjct: 255 QILATLKGHTKKVTSVVFHP---SQDLVFSASPDATIRIWS-VPNASCVQVVRAHESAVT 310

Query: 297 AARWAPCGRRILSGGFDFALHLTDLETG---TQLFSGRSDFRITTLKFHPKDHNIFLCGG 353
                  G  +LS   D     +D++TG   T++    S   +T  +FHP D  IF  G 
Sbjct: 311 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP-DGLIFGTGT 369

Query: 354 FSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFR 413
             S++K WD++    + ++         I F   G    ++ D       D ++  WD R
Sbjct: 370 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD-------DSSVKLWDLR 422

Query: 414 TSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST 455
                        F   SL         +   +G YLAL  T
Sbjct: 423 KLKNFKTLQLDNNFEVKSL---------IFDQSGTYLALGGT 455



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 45/209 (21%), Positives = 81/209 (38%), Gaps = 14/209 (6%)

Query: 336 ITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSST 395
           I  L   P D N  L GG    +  +D  + +++ + K   ++   ++       F  S 
Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVV-------FHPSQ 276

Query: 396 DASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST 455
           D     S D TI  W    ++ +     HE      L+LH      L+ ++  Y A FS 
Sbjct: 277 DLVFSASPDATIRIWSVPNASCVQVVRAHES-AVTGLSLHATGDYLLSSSDDQYWA-FSD 334

Query: 456 VWPYRMSRRRRYEGHKVEGYSVGC-ECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514
           +   R+  +   E     G S+ C +  P G +  TG+ D ++ ++  +  +      GH
Sbjct: 335 IQTGRVLTKVTDE---TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGH 391

Query: 515 TQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           +       +       LAT +    +K+W
Sbjct: 392 SGPITSIAFSE-NGYYLATAADDSSVKLW 419



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 22/94 (23%), Positives = 41/94 (43%), Gaps = 7/94 (7%)

Query: 456 VWPYRMSRRRRYEGH------KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRAC 509
           V P  +S+ R+   H       + G      C    + ++TG AD  V+++   +     
Sbjct: 199 VKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILA 258

Query: 510 TLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           TL+GHT+      +HP    ++ + S    ++IW
Sbjct: 259 TLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIW 291


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%)

Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291
           + V  K L  L GH G V + Q      + ++++S S D+T KVWNA ++G C+ T   H
Sbjct: 289 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 342

Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351
           T  VR        +R++SG  D  L + D+ETG  L        +  ++    D    + 
Sbjct: 343 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 398

Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
           G +   +K WD  T   + + +    +   + F  +G   +S        S D +I  WD
Sbjct: 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 449

Query: 412 FRTSAKISNQIFHERFT 428
             T   I     H+  T
Sbjct: 450 VETGNCIHTLTGHQSLT 466



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%)

Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323
           ++S S D T +VW+ +++G CL     H  AVR  ++   GRR++SG +DF + + D ET
Sbjct: 356 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 412

Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345
                               G  + SG  D  I            TL  H          
Sbjct: 413 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 472

Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
            NI + G   S +K WDI+TG+ +++ +   +    +  L+    F+ ++      S D 
Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 526

Query: 406 TIIAWDFRTSAKISNQI 422
           T+  WD +T   I N +
Sbjct: 527 TVKLWDLKTGEFIRNLV 543



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%)

Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279
           Y+  H  +T   R  L     L+GH   V T +Q+C      + ++S S D T KVW+AV
Sbjct: 237 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 291

Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336
            +G CL+T   HT  V +++       I+SG  D  L + + ETG     L+   S  R 
Sbjct: 292 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 347

Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396
             +  H K     + G   + ++ WDI TG+ +      +     + +  +G   +S   
Sbjct: 348 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 399

Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454
                + D  +  WD  T             TC          V+  Q +G ++   S  
Sbjct: 400 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 442

Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510
               VW            GH  +  + G E     ++LV+G+AD  V ++  +T     T
Sbjct: 443 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 498

Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           LQG  +     T      + + T S  G +K+W
Sbjct: 499 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 531


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%)

Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291
           + V  K L  L GH G V + Q      + ++++S S D+T KVWNA ++G C+ T   H
Sbjct: 407 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 460

Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351
           T  VR        +R++SG  D  L + D+ETG  L        +  ++    D    + 
Sbjct: 461 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 516

Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
           G +   +K WD  T   + + +    +   + F  +G   +S        S D +I  WD
Sbjct: 517 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 567

Query: 412 FRTSAKISNQIFHERFT 428
             T   I     H+  T
Sbjct: 568 VETGNCIHTLTGHQSLT 584



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%)

Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323
           ++S S D T +VW+ +++G CL     H  AVR  ++   GRR++SG +DF + + D ET
Sbjct: 474 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 530

Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345
                               G  + SG  D  I            TL  H          
Sbjct: 531 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 590

Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
            NI + G   S +K WDI+TG+ +++ +   +    +  L+    F+ ++      S D 
Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 644

Query: 406 TIIAWDFRTSAKISNQI 422
           T+  WD +T   I N +
Sbjct: 645 TVKLWDLKTGEFIRNLV 661



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%)

Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279
           Y+  H  +T   R  L     L+GH   V T +Q+C      + ++S S D T KVW+AV
Sbjct: 355 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 409

Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336
            +G CL+T   HT  V +++       I+SG  D  L + + ETG     L+   S  R 
Sbjct: 410 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 465

Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396
             +  H K     + G   + ++ WDI TG+ +      +     + +  +G   +S   
Sbjct: 466 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 517

Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454
                + D  +  WD  T             TC          V+  Q +G ++   S  
Sbjct: 518 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 560

Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510
               VW            GH  +  + G E     ++LV+G+AD  V ++  +T     T
Sbjct: 561 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 616

Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           LQG  +     T      + + T S  G +K+W
Sbjct: 617 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%)

Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291
           + V  K L  L GH G V + Q      + ++++S S D+T KVWNA ++G C+ T   H
Sbjct: 327 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 380

Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351
           T  VR        +R++SG  D  L + D+ETG  L        +  ++    D    + 
Sbjct: 381 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 436

Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
           G +   +K WD  T   + + +    +   + F  +G   +S        S D +I  WD
Sbjct: 437 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 487

Query: 412 FRTSAKISNQIFHERFT 428
             T   I     H+  T
Sbjct: 488 VETGNCIHTLTGHQSLT 504



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%)

Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323
           ++S S D T +VW+ +++G CL     H  AVR  ++   GRR++SG +DF + + D ET
Sbjct: 394 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 450

Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345
                               G  + SG  D  I            TL  H          
Sbjct: 451 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 510

Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
            NI + G   S +K WDI+TG+ +++ +   +    +  L+    F+ ++      S D 
Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 564

Query: 406 TIIAWDFRTSAKISNQI 422
           T+  WD +T   I N +
Sbjct: 565 TVKLWDLKTGEFIRNLV 581



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%)

Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279
           Y+  H  +T   R  L     L+GH   V T +Q+C      + ++S S D T KVW+AV
Sbjct: 275 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 329

Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336
            +G CL+T   HT  V +++       I+SG  D  L + + ETG     L+   S  R 
Sbjct: 330 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 385

Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396
             +  H K     + G   + ++ WDI TG+ +      +     + +  +G   +S   
Sbjct: 386 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 437

Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454
                + D  +  WD  T             TC          V+  Q +G ++   S  
Sbjct: 438 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 480

Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510
               VW            GH  +  + G E     ++LV+G+AD  V ++  +T     T
Sbjct: 481 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 536

Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           LQG  +     T      + + T S  G +K+W
Sbjct: 537 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 569


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 68/275 (24%), Positives = 109/275 (39%), Gaps = 33/275 (12%)

Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPVLS-----KSHMLLSTSMDKTFKVWNAVDSGHCLQ 286
           +VP   L H LRGH   V  I + P  +     K   L S + D + K+W+ +DS   + 
Sbjct: 259 SVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWS-LDSDEPVA 317

Query: 287 TYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRS-DFRITTLKFHPKD 345
               HT  V    W P GR + +  +D +  L DLE   ++         +  + FH +D
Sbjct: 318 DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH-QD 376

Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
            ++   GG  +  + WD+RTG+ +   +  +++   I F   G    +        S D 
Sbjct: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATG-------SGDN 429

Query: 406 TIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLAL-----FSTVWPY- 459
           T   WD R    +     H+              V     +GN+L        + +W + 
Sbjct: 430 TCKVWDLRQRRCVYTIPAHQNLV---------TGVKFEPIHGNFLLTGAYDNTAKIWTHP 480

Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSAD 494
             S  +   GH  EG  +G + S  G L+ T S D
Sbjct: 481 GWSPLKTLAGH--EGKVMGLDISSDGQLIATCSYD 513



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 55/208 (26%), Positives = 84/208 (40%), Gaps = 16/208 (7%)

Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396
           +T+   PKD N+  C    S +K W + + + +   +    +   +++   G  FL +T 
Sbjct: 285 STVSLDPKDVNLASCAADGS-VKLWSLDSDEPVADIEGHTVRVARVMWHPSG-RFLGTT- 341

Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTV 456
                  DR+   WD     +I +Q  H       +A H  +   LA T G  L  F  V
Sbjct: 342 -----CYDRSWRLWDLEAQEEILHQEGHSMGVY-DIAFH--QDGSLAGTGG--LDAFGRV 391

Query: 457 WPYRMSRRRRY-EGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHT 515
           W  R  R   + EGH  E Y  G   SP G  + TGS D    ++  R      T+  H 
Sbjct: 392 WDLRTGRCIMFLEGHLKEIY--GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449

Query: 516 QACVGTTYHPVLPSVLATCSWGGDMKIW 543
               G  + P+  + L T ++    KIW
Sbjct: 450 NLVTGVKFEPIHGNFLLTGAYDNTAKIW 477



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 7/72 (9%)

Query: 479 CECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV-------L 531
           C  SP   +L T    G   ++S    +   TL+GH        +HP            L
Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296

Query: 532 ATCSWGGDMKIW 543
           A+C+  G +K+W
Sbjct: 297 ASCAADGSVKLW 308


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 33/96 (34%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 242 LRGHRGPVNTIQWCPVLSKSH------MLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAV 295
           L+ H   + TI+W P    ++      ML S S D T ++W+ VD G C+ T + H E V
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWD-VDRGICIHTLTKHQEPV 445

Query: 296 RAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331
            +  ++P GR + SG FD  +H+ + +TG  + S R
Sbjct: 446 YSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 15/143 (10%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           +GH   VN I+W P     ++L S S D T K+W+ +   +C+     H + +   +W+P
Sbjct: 346 QGHTNEVNAIKWDPT---GNLLASCSDDMTLKIWS-MKQDNCVHDLQAHNKEIYTIKWSP 401

Query: 303 CGR---------RILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352
            G           + S  FD  + L D++ G  + +  +    + ++ F P D      G
Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP-DGRYLASG 460

Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375
            F   +  W+ +TG ++ SY+ T
Sbjct: 461 SFDKCVHIWNTQTGALVHSYRGT 483



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/179 (22%), Positives = 66/179 (36%), Gaps = 17/179 (9%)

Query: 231 ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSG-------- 282
           +  +P      LRGH   V    W PV   S +L S S D T ++WN  ++         
Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNLSENSTSGSTQLV 210

Query: 283 --HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT 337
             HC++       +   V +  W   G  + +G +D    +   +       G+    I 
Sbjct: 211 LRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF 270

Query: 338 TLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396
            LK++ K  N  L  G       WD  TG+  + +       LD+ +    +    STD
Sbjct: 271 ALKWNKKG-NFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTD 328



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 43/223 (19%), Positives = 84/223 (37%), Gaps = 59/223 (26%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278
           H+GP+  ++W     K + +LS  +DKT  +W+A                          
Sbjct: 265 HKGPIFALKWN---KKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT 321

Query: 279 --------------VDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324
                         +     ++T+  HT  V A +W P G  + S   D  L +  ++  
Sbjct: 322 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD 381

Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375
             +   ++ +  I T+K+ P        + N+ L    F S ++ WD+  G  + +    
Sbjct: 382 NCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH 441

Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKI 418
            +    + F  +G  +L+S       S D+ +  W+ +T A +
Sbjct: 442 QEPVYSVAFSPDG-RYLAS------GSFDKCVHIWNTQTGALV 477


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 22/191 (11%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304
           H   VN I  C        L+S S D T KVWNA   G C+ T   H + V+A  +A   
Sbjct: 74  HTDWVNDIVLC---CNGKTLISASSDTTVKVWNA-HKGFCMSTLRTHKDYVKALAYAKDK 129

Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDH----------NIFLCGGF 354
             + S G D  + L D+ T T L +  +    ++L  + KD            I + G  
Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGN-KDSIYSLAMNQLGTIIVSGST 188

Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRT 414
              ++ WD RT   +   K        +L  R+G++ LS        S+D TI  W    
Sbjct: 189 EKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSG-------SSDGTIRLWSLGQ 241

Query: 415 SAKISNQIFHE 425
              I+    H+
Sbjct: 242 QRCIATYRVHD 252



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%)

Query: 239 LFHLRGHRGPVNTIQWCPVLSKSH-MLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRA 297
           L  L+GH   V  +    +L++     LS S D T ++W+ +    C+ TY +H E V A
Sbjct: 203 LMKLKGHTDNVKAL----LLNRDGTQCLSGSSDGTIRLWS-LGQQRCIATYRVHDEGVWA 257

Query: 298 ARWAPCGRRILSGGFDFALHLTDL 321
            +       + SGG D  ++ TDL
Sbjct: 258 LQVNDAFTHVYSGGRDRKIYCTDL 281


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           R H   V ++ +C   S     ++ S DKT KVW A      L + S H   VR A+++P
Sbjct: 62  RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 117

Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
            GR I+S   D  + L D  +   + S      F +T + FHP    I    G  + +K 
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 175

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399
           WD+RT ++++ Y+        + F   G+  ++++  ST
Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 214



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 59/271 (21%), Positives = 103/271 (38%), Gaps = 27/271 (9%)

Query: 235 PRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEA 294
           P+   +   GH+  V  + + P     H+L S S DKT ++W     G     +  HT  
Sbjct: 12  PQSRAYRFTGHKDAVTCVNFSP---SGHLLASGSRDKTVRIWVPNVKGES-TVFRAHTAT 67

Query: 295 VRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFR-ITTLKFHPKDHNIFLCGG 353
           VR+  +   G+  ++   D  + +        LFS       +   KF P D  + +   
Sbjct: 68  VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSAS 126

Query: 354 FSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFR 413
               +K WD  + + + SY    +    + ++    +F  S         D T+  WD R
Sbjct: 127 DDKTVKLWDKSSRECVHSY---CEHGGFVTYV----DFHPSGTCIAAAGMDNTVKVWDVR 179

Query: 414 TSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYR----MSRRRRYEG 469
           T   + +   H       L+ HP         +GNYL   S+    +    M  R  Y  
Sbjct: 180 THRLLQHYQLHSA-AVNGLSFHP---------SGNYLITASSDSTLKILDLMEGRLLYTL 229

Query: 470 HKVEGYSVGCECSPGGDLLVTGSADGRVLMY 500
           H  +G +     S  G+   +G +D +V+++
Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 49/246 (19%), Positives = 86/246 (34%), Gaps = 14/246 (5%)

Query: 269 MDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLF 328
           MD    VW+        + ++ H +AV    ++P G  + SG  D  + +       +  
Sbjct: 1   MDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59

Query: 329 SGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREG 388
             R+            D   F+       +K W     K + S    I       F  +G
Sbjct: 60  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119

Query: 389 SEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGN 448
              +S++D       D+T+  WD  +   + +   H  F    +  HP      A    N
Sbjct: 120 RLIVSASD-------DKTVKLWDKSSRECVHSYCEHGGFVT-YVDFHPSGTCIAAAGMDN 171

Query: 449 YLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRA 508
            + ++  V  +R+ +  +     V G S      P G+ L+T S+D  + +         
Sbjct: 172 TVKVWD-VRTHRLLQHYQLHSAAVNGLSF----HPSGNYLITASSDSTLKILDLMEGRLL 226

Query: 509 CTLQGH 514
            TL GH
Sbjct: 227 YTLHGH 232



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 44/219 (20%), Positives = 86/219 (39%), Gaps = 24/219 (10%)

Query: 328 FSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILF 384
           F+G  D  +T + F P  H +   G     ++ W         V R++ AT++    + F
Sbjct: 19  FTGHKD-AVTCVNFSPSGH-LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHF 73

Query: 385 LREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLA 443
             +G  F++++D       D+T+  W       + +   H  +  C   +  P   + ++
Sbjct: 74  CSDGQSFVTASD-------DKTVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVS 124

Query: 444 QTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFR 503
            ++   + L+      + SR   +   +  G+    +  P G  +     D  V ++  R
Sbjct: 125 ASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179

Query: 504 TASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKI 542
           T       Q H+ A  G ++HP   + L T S    +KI
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKI 217


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           R H   V ++ +C   S     ++ S DKT KVW A      L + S H   VR A+++P
Sbjct: 100 RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
            GR I+S   D  + L D  +   + S      F +T + FHP    I    G  + +K 
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 213

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399
           WD+RT ++++ Y+        + F   G+  ++++  ST
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 57/274 (20%), Positives = 98/274 (35%), Gaps = 17/274 (6%)

Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300
           H +GHR  V  + +      +  L S SMD    VW+        + ++ H +AV    +
Sbjct: 14  HFKGHRDAVTCVDFS---INTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF 69

Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
           +P G  + SG  D  + +       +    R+            D   F+       +K 
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           W     K + S    I       F  +G   +S++D       D+T+  WD  +   + +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-------DKTVKLWDKSSRECVHS 182

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
              H  F    +  HP      A    N + ++  V  +R+ +  +     V G S    
Sbjct: 183 YCEHGGFVT-YVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSF--- 237

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514
             P G+ L+T S+D  + +          TL GH
Sbjct: 238 -HPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/117 (26%), Positives = 48/117 (41%), Gaps = 4/117 (3%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304
           H G V  + + P       + +  MD T KVW+ V +   LQ Y LH+ AV    + P G
Sbjct: 186 HGGFVTYVDFHP---SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSG 241

Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361
             +++   D  L + DL  G  L++        T     +    F  GG   ++  W
Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 51/258 (19%), Positives = 104/258 (40%), Gaps = 26/258 (10%)

Query: 291 HTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNI 348
           H +AV    ++   +++ SG  D  L +  ++  ++   F+G  D  +T + F P  H +
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGH-L 75

Query: 349 FLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
              G     ++ W         V R++ AT++    + F  +G  F++++D       D+
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHFCSDGQSFVTASD-------DK 125

Query: 406 TIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRR 464
           T+  W       + +   H  +  C   +  P   + ++ ++   + L+      + SR 
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWD-----KSSRE 178

Query: 465 RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYH 524
             +   +  G+    +  P G  +     D  V ++  RT       Q H+ A  G ++H
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238

Query: 525 PVLPSVLATCSWGGDMKI 542
           P   + L T S    +KI
Sbjct: 239 P-SGNYLITASSDSTLKI 255


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           R H   V ++ +C   S     ++ S DKT KVW A      L + S H   VR A+++P
Sbjct: 100 RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
            GR I+S   D  + L D  +   + S      F +T + FHP    I    G  + +K 
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 213

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399
           WD+RT ++++ Y+        + F   G+  ++++  ST
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 57/274 (20%), Positives = 98/274 (35%), Gaps = 17/274 (6%)

Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300
           H +GHR  V  + +      +  L S SMD    VW+        + ++ H +AV    +
Sbjct: 14  HFKGHRDAVTCVDFS---INTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF 69

Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360
           +P G  + SG  D  + +       +    R+            D   F+       +K 
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420
           W     K + S    I       F  +G   +S++D       D+T+  WD  +   + +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-------DKTVKLWDKSSRECVHS 182

Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480
              H  F    +  HP      A    N + ++  V  +R+ +  +     V G S    
Sbjct: 183 YCEHGGFVT-YVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSF--- 237

Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514
             P G+ L+T S+D  + +          TL GH
Sbjct: 238 -HPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/117 (26%), Positives = 48/117 (41%), Gaps = 4/117 (3%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304
           H G V  + + P       + +  MD T KVW+ V +   LQ Y LH+ AV    + P G
Sbjct: 186 HGGFVTYVDFHP---SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSG 241

Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361
             +++   D  L + DL  G  L++        T     +    F  GG   ++  W
Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 51/258 (19%), Positives = 104/258 (40%), Gaps = 26/258 (10%)

Query: 291 HTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNI 348
           H +AV    ++   +++ SG  D  L +  ++  ++   F+G  D  +T + F P  H +
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGH-L 75

Query: 349 FLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405
              G     ++ W         V R++ AT++    + F  +G  F++++D       D+
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHFCSDGQSFVTASD-------DK 125

Query: 406 TIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRR 464
           T+  W       + +   H  +  C   +  P   + ++ ++   + L+      + SR 
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWD-----KSSRE 178

Query: 465 RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYH 524
             +   +  G+    +  P G  +     D  V ++  RT       Q H+ A  G ++H
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238

Query: 525 PVLPSVLATCSWGGDMKI 542
           P   + L T S    +KI
Sbjct: 239 P-SGNYLITASSDSTLKI 255


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/311 (22%), Positives = 116/311 (37%), Gaps = 29/311 (9%)

Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301
           LRGH   +  + W    + S +L+S S D    +W++  +   +    L +  V    +A
Sbjct: 51  LRGHLAKIYAMHWG---TDSRLLVSASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYA 106

Query: 302 PCGRRILSGGFDFALHLTDLETG------TQLFSGRSDFRITTLKFHPKDHNIFLCGGFS 355
           P G  +  GG D    +  L+T       ++   G + + ++  +F   D N  +     
Sbjct: 107 PSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGY-LSCCRF--LDDNQIITSSGD 163

Query: 356 SEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTS 415
           +    WDI TG+    +       + +    +G  F+S        + D +I  WD R S
Sbjct: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSG-------ACDASIKLWDVRDS 216

Query: 416 AKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGY 475
                 I HE     ++A  P    F   ++     LF       +     Y    +   
Sbjct: 217 MCRQTFIGHES-DINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL---LMYSHDNIICG 272

Query: 476 SVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQ--ACVGTTYHPVLPSVLAT 533
                 S  G LL+ G  D    ++      RA  L GH    +C+G T   +    +AT
Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGM---AVAT 329

Query: 534 CSWGGDMKIWH 544
            SW   +KIW+
Sbjct: 330 GSWDSFLKIWN 340


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/166 (25%), Positives = 75/166 (45%), Gaps = 8/166 (4%)

Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296
           K+L  L GH+  + ++ + P       + S S D   K+W+    G C+  Y  H++AVR
Sbjct: 96  KILRTLMGHKANICSLDFHPY---GEFVASGSQDTNIKLWDIRRKG-CVFRYRGHSQAVR 151

Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGF 354
             R++P G+ + S   D  + L DL  G  +  F G +   +  ++FHP ++ +   G  
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG-PVNVVEFHPNEY-LLASGSS 209

Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTR 400
              ++ WD+   +V+   +        +LF  +G    S    S R
Sbjct: 210 DRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLR 255



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 46/185 (24%), Positives = 77/185 (41%), Gaps = 13/185 (7%)

Query: 257 VLSK-SHMLLSTSMDKT-FKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDF 314
           VL K S  LL+T  D     +W+ ++  +C+ + + HT  V + R       I++G    
Sbjct: 27  VLGKASGRLLATGGDDCRVNLWS-INKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85

Query: 315 ALHLTDLETGTQLFSGRS-DFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYK 373
           ++ + DLE    L +       I +L FHP    +   G   + +K WDIR    +  Y+
Sbjct: 86  SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFRYR 144

Query: 374 ATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLA 433
              Q    + F  +G    S+ D       D T+  WD  T+ K+ ++          + 
Sbjct: 145 GHSQAVRCLRFSPDGKWLASAAD-------DHTVKLWDL-TAGKMMSEFPGHTGPVNVVE 196

Query: 434 LHPRE 438
            HP E
Sbjct: 197 FHPNE 201



 Score = 30.0 bits (66), Expect = 5.7
 Identities = 16/58 (27%), Positives = 27/58 (46%), Gaps = 1/58 (1%)

Query: 486 DLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543
           +L+V GS  G + ++    A    TL GH        +HP     +A+ S   ++K+W
Sbjct: 76  ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLW 132



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 30/129 (23%), Positives = 46/129 (35%), Gaps = 16/129 (12%)

Query: 402 SADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRM 461
           S   +I  WD   +  +   + H+   C SL  HP      + +    + L+        
Sbjct: 82  SQSGSIRVWDLEAAKILRTLMGHKANIC-SLDFHPYGEFVASGSQDTNIKLWDI------ 134

Query: 462 SRRR----RYEGHKVEGYSVGC-ECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQ 516
            RR+    RY GH     +V C   SP G  L + + D  V ++            GHT 
Sbjct: 135 -RRKGCVFRYRGHS---QAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190

Query: 517 ACVGTTYHP 525
                 +HP
Sbjct: 191 PVNVVEFHP 199


>gi|134133292 WD repeat domain 27 [Homo sapiens]
          Length = 857

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 75/314 (23%), Positives = 121/314 (38%), Gaps = 38/314 (12%)

Query: 253 QWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGF 312
           QW      +H+LL    D +     AV SGH          AV A  W+   R +LS   
Sbjct: 556 QWLACGLANHLLLV--FDASLTGTPAVFSGH--------DGAVNAVCWSQDRRWLLSAAR 605

Query: 313 DFALHLTDLETGT-QLFSGRSDFR--ITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGK-V 368
           D  L +         L  G+  F   I + +F+  D  I L  G   ++  + I T K  
Sbjct: 606 DGTLRMWSARGAELALLLGKDMFSKPIQSAQFYYIDAFILLSSGPEFQLLRYHIDTCKDE 665

Query: 369 MRSYKATIQQTLDILFLREGSEFLSSTDAST--------RDSADRTIIAWDFRTS----- 415
           ++ YK   +  L       G+  ++S  A              +RT+  +D         
Sbjct: 666 IKRYKQKSKSKLICRLSTTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAV 725

Query: 416 -AKISNQIFHERFTCPSLALHPREP----VFLAQTNGNYLALFSTVWPYRMSR-RRRYEG 469
            A+  ++  H+       +   ++P    +FL    G+ + L    W  R  R  R +EG
Sbjct: 726 IAEAHSRPVHQICQNKGSSFTTQQPQAYNLFLTTAIGDGMRL----WDLRTLRCERHFEG 781

Query: 470 HKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPS 529
           H   GY  G   SP G     G+ D    +Y   +++ +  L GHT    G  ++P  P 
Sbjct: 782 HPTRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQ 841

Query: 530 VLATCSWGGDMKIW 543
            LAT +  G ++++
Sbjct: 842 -LATATLDGKLQLF 854



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 13/116 (11%)

Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVW-----NAVDSGHCLQTYSLHTEAVR 296
           L+GH GPV  +++CP   ++  L+S S D+ FKVW     + + S   L  Y L +  + 
Sbjct: 190 LQGHLGPVTAVEFCP--WRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAYPLLSLFID 247

Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLC 351
           A       R++++G  D  L +  L  G       R D R  T  F  +     LC
Sbjct: 248 AE-----SRQLVTGCADGQLWIFSLMDGHHYRRVARVDLRKKTETFSTRRVKSGLC 298


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 38/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 244 GHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPC 303
           GH   V+ +++ P    S+ L + S DKT ++W+A   G+ ++ ++ H   V +  ++P 
Sbjct: 424 GHLADVDCVKFHP---NSNYLATGSTDKTVRLWSA-QQGNSVRLFTGHRGPVLSLAFSPN 479

Query: 304 GRRILSGGFDFALHLTDLETGT--QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361
           G+ + S G D  L L DL +GT  +   G +D  IT+L F P D  +       + ++ W
Sbjct: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTD-NITSLTFSP-DSGLIASASMDNSVRVW 537

Query: 362 DIR 364
           DIR
Sbjct: 538 DIR 540



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 36/148 (24%), Positives = 58/148 (39%), Gaps = 19/148 (12%)

Query: 402 SADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST-----V 456
           S DRT   W F  +  +     H       +  HP         N NYLA  ST     +
Sbjct: 403 SHDRTARLWSFDRTYPLRIYAGHLA-DVDCVKFHP---------NSNYLATGSTDKTVRL 452

Query: 457 WPYRMSRR-RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHT 515
           W  +     R + GH+  G  +    SP G  L +   D R+ ++   + +    L+GHT
Sbjct: 453 WSAQQGNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510

Query: 516 QACVGTTYHPVLPSVLATCSWGGDMKIW 543
                 T+ P    ++A+ S    +++W
Sbjct: 511 DNITSLTFSPD-SGLIASASMDNSVRVW 537


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 9/127 (7%)

Query: 244 GHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWN--AVDSGHC-LQTYSLHTEAVRAARW 300
           GH   V  +QW P  +++ +  S S D + ++W+  A  S  C L T + H   V    W
Sbjct: 259 GHTRSVEDLQWSP--TENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISW 316

Query: 301 APCGRRILSGGFDFALHLTDL---ETGTQLFSGRSDFR-ITTLKFHPKDHNIFLCGGFSS 356
           +     +LSGG D AL + DL   ++G+ + + +     +T++++HP+D  +F   G   
Sbjct: 317 SRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADH 376

Query: 357 EMKAWDI 363
           ++  WD+
Sbjct: 377 QITQWDL 383



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 29/203 (14%)

Query: 225 LNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSG-- 282
           L +  ++     K +F   GH G    + W P ++    LL+    K   +W   D G  
Sbjct: 193 LAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGR--LLTGDCQKNIHLWTPTDGGSW 250

Query: 283 HCLQT-YSLHTEAVRAARWAPCGRRILSG-GFDFALHLTDLETGTQLFSGRSDFRITTLK 340
           H  Q  +  HT +V   +W+P    + +    D ++ + D+              +TT  
Sbjct: 251 HVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPS-----KACMLTTAT 305

Query: 341 FHPKDHNIF---------LCGGFSSEMKAWDIR---TGKVMRSYKATIQQTLDILFLREG 388
            H  D N+          L GG    +K WD+R   +G  + ++K  +     + +  + 
Sbjct: 306 AHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQD 365

Query: 389 SEFLSSTDASTRDSADRTIIAWD 411
           S   +++       AD  I  WD
Sbjct: 366 SGVFAAS------GADHQITQWD 382


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285
           ++ ++V  H L+ H   + TI+W P        + + ML S S D T ++W+ ++ G C 
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 447

Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331
            T + H E V +  ++P G+ + SG FD  +H+ + ++G  + S R
Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           +GH   VN I+W P      +L S S D T K+W+ +    C+     H + +   +W+P
Sbjct: 358 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 413

Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352
            G           + S  FD  + L D+E G    +  +    + ++ F P D      G
Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 472

Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375
            F   +  W+ ++G ++ SY+ T
Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGT 495



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%)

Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278
           +N+H K      E  +P      LRGH   V    W PV   S +L S S D T ++WN 
Sbjct: 154 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 210

Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325
            ++           HC++       +   V +  W   G  + +G +D    +   +   
Sbjct: 211 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 270

Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385
               G+    I  LK++ K  N  L  G       WD  TG+  + +       LD+ + 
Sbjct: 271 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329

Query: 386 REGSEFLSSTD 396
              +    STD
Sbjct: 330 NNTTFASCSTD 340



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278
           H+GP+  ++W     K + +LS  +DKT  +W+A                          
Sbjct: 277 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 333

Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324
                +  C+           +T+  HT  V A +W P G  + S   D  L +  ++  
Sbjct: 334 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393

Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375
             +   ++ +  I T+K+ P        + NI L    F S ++ WDI  G    +    
Sbjct: 394 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 453

Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
            +    + F  +G ++L+S       S D+ +  W+
Sbjct: 454 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 482



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%)

Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528
           GH+ E +   C  +P  DLL +GS D    +++    S   + Q   + C+    H V P
Sbjct: 179 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 235

Query: 529 S--------------VLATCSWGGDMKIW 543
           S              +LAT S+ G  +IW
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW 264


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285
           ++ ++V  H L+ H   + TI+W P        + + ML S S D T ++W+ ++ G C 
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 447

Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331
            T + H E V +  ++P G+ + SG FD  +H+ + ++G  + S R
Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           +GH   VN I+W P      +L S S D T K+W+ +    C+     H + +   +W+P
Sbjct: 358 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 413

Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352
            G           + S  FD  + L D+E G    +  +    + ++ F P D      G
Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 472

Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375
            F   +  W+ ++G ++ SY+ T
Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGT 495



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%)

Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278
           +N+H K      E  +P      LRGH   V    W PV   S +L S S D T ++WN 
Sbjct: 154 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 210

Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325
            ++           HC++       +   V +  W   G  + +G +D    +   +   
Sbjct: 211 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 270

Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385
               G+    I  LK++ K  N  L  G       WD  TG+  + +       LD+ + 
Sbjct: 271 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329

Query: 386 REGSEFLSSTD 396
              +    STD
Sbjct: 330 NNTTFASCSTD 340



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278
           H+GP+  ++W     K + +LS  +DKT  +W+A                          
Sbjct: 277 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 333

Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324
                +  C+           +T+  HT  V A +W P G  + S   D  L +  ++  
Sbjct: 334 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393

Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375
             +   ++ +  I T+K+ P        + NI L    F S ++ WDI  G    +    
Sbjct: 394 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 453

Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
            +    + F  +G ++L+S       S D+ +  W+
Sbjct: 454 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 482



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%)

Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528
           GH+ E +   C  +P  DLL +GS D    +++    S   + Q   + C+    H V P
Sbjct: 179 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 235

Query: 529 S--------------VLATCSWGGDMKIW 543
           S              +LAT S+ G  +IW
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW 264


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285
           ++ ++V  H L+ H   + TI+W P        + + ML S S D T ++W+ ++ G C 
Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 498

Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331
            T + H E V +  ++P G+ + SG FD  +H+ + ++G  + S R
Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           +GH   VN I+W P      +L S S D T K+W+ +    C+     H + +   +W+P
Sbjct: 409 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 464

Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352
            G           + S  FD  + L D+E G    +  +    + ++ F P D      G
Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 523

Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375
            F   +  W+ ++G ++ SY+ T
Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGT 546



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%)

Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278
           +N+H K      E  +P      LRGH   V    W PV   S +L S S D T ++WN 
Sbjct: 205 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 261

Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325
            ++           HC++       +   V +  W   G  + +G +D    +   +   
Sbjct: 262 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 321

Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385
               G+    I  LK++ K  N  L  G       WD  TG+  + +       LD+ + 
Sbjct: 322 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380

Query: 386 REGSEFLSSTD 396
              +    STD
Sbjct: 381 NNTTFASCSTD 391



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278
           H+GP+  ++W     K + +LS  +DKT  +W+A                          
Sbjct: 328 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 384

Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324
                +  C+           +T+  HT  V A +W P G  + S   D  L +  ++  
Sbjct: 385 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444

Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375
             +   ++ +  I T+K+ P        + NI L    F S ++ WDI  G    +    
Sbjct: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 504

Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
            +    + F  +G ++L+S       S D+ +  W+
Sbjct: 505 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 533



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%)

Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528
           GH+ E +   C  +P  DLL +GS D    +++    S   + Q   + C+    H V P
Sbjct: 230 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 286

Query: 529 S--------------VLATCSWGGDMKIW 543
           S              +LAT S+ G  +IW
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW 315


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285
           ++ ++V  H L+ H   + TI+W P        + + ML S S D T ++W+ ++ G C 
Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 498

Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331
            T + H E V +  ++P G+ + SG FD  +H+ + ++G  + S R
Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%)

Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302
           +GH   VN I+W P      +L S S D T K+W+ +    C+     H + +   +W+P
Sbjct: 409 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 464

Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352
            G           + S  FD  + L D+E G    +  +    + ++ F P D      G
Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 523

Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375
            F   +  W+ ++G ++ SY+ T
Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGT 546



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%)

Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278
           +N+H K      E  +P      LRGH   V    W PV   S +L S S D T ++WN 
Sbjct: 205 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 261

Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325
            ++           HC++       +   V +  W   G  + +G +D    +   +   
Sbjct: 262 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 321

Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385
               G+    I  LK++ K  N  L  G       WD  TG+  + +       LD+ + 
Sbjct: 322 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380

Query: 386 REGSEFLSSTD 396
              +    STD
Sbjct: 381 NNTTFASCSTD 391



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%)

Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278
           H+GP+  ++W     K + +LS  +DKT  +W+A                          
Sbjct: 328 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 384

Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324
                +  C+           +T+  HT  V A +W P G  + S   D  L +  ++  
Sbjct: 385 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444

Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375
             +   ++ +  I T+K+ P        + NI L    F S ++ WDI  G    +    
Sbjct: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 504

Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411
            +    + F  +G ++L+S       S D+ +  W+
Sbjct: 505 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 533



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%)

Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528
           GH+ E +   C  +P  DLL +GS D    +++    S   + Q   + C+    H V P
Sbjct: 230 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 286

Query: 529 S--------------VLATCSWGGDMKIW 543
           S              +LAT S+ G  +IW
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW 315


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,848,777
Number of Sequences: 37866
Number of extensions: 1126934
Number of successful extensions: 4668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 166
Number of HSP's that attempted gapping in prelim test: 3698
Number of HSP's gapped (non-prelim): 828
length of query: 544
length of database: 18,247,518
effective HSP length: 107
effective length of query: 437
effective length of database: 14,195,856
effective search space: 6203589072
effective search space used: 6203589072
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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