Search of human proteins with 239787754

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
         (407 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            835   0.0  
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            757   0.0  
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            718   0.0  
gi|26665869 WD repeat domain 51B [Homo sapiens]                       424   e-119
gi|32189425 WD repeat domain 69 [Homo sapiens]                        162   5e-40
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   157   2e-38
gi|23199987 WD repeat domain 5B [Homo sapiens]                        156   4e-38
gi|16554629 WD repeat domain 5 [Homo sapiens]                         136   4e-32
gi|16554627 WD repeat domain 5 [Homo sapiens]                         136   4e-32
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      132   6e-31
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   130   2e-30
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   130   2e-30
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   130   2e-30
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           130   2e-30
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    129   6e-30
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   128   1e-29
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    126   3e-29
gi|113865883 WD repeat domain 38 [Homo sapiens]                       125   5e-29
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...   125   9e-29
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...   125   9e-29
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...   117   2e-26
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   117   2e-26
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]         116   3e-26
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]         116   3e-26
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    116   3e-26
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    116   3e-26
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    116   3e-26
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         115   9e-26
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         115   9e-26
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         115   9e-26

>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  835 bits (2157), Expect = 0.0
 Identities = 407/407 (100%), Positives = 407/407 (100%)

Query: 1   MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
           MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH
Sbjct: 1   MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
           HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240

Query: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
           GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300

Query: 301 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT 360
           NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT
Sbjct: 301 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT 360

Query: 361 STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 407
           STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP
Sbjct: 361 STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 407


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  757 bits (1955), Expect = 0.0
 Identities = 369/369 (100%), Positives = 369/369 (100%)

Query: 39  MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 98
           MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 99  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
           FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR
Sbjct: 61  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
           LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180

Query: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
           HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240

Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 338
           FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR
Sbjct: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300

Query: 339 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 398
           GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ
Sbjct: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360

Query: 399 QLIMQRATP 407
           QLIMQRATP
Sbjct: 361 QLIMQRATP 369



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 4/102 (3%)

Query: 11  LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
           L +H++ H  AV  + F  +   L + S DS L +  +      Y   GH+   T V FS
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242

Query: 71  PSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRS 108
            +G   ASG  D+ V +W  N      GE T      AT+ S
Sbjct: 243 RTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS 284


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  718 bits (1853), Expect = 0.0
 Identities = 359/407 (88%), Positives = 359/407 (88%), Gaps = 48/407 (11%)

Query: 1   MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
           MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH
Sbjct: 1   MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
           HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240

Query: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
           GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300

Query: 301 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT 360
           NFDIVDHGEVTKVPRPPATLASSMGNL                                 
Sbjct: 301 NFDIVDHGEVTKVPRPPATLASSMGNL--------------------------------- 327

Query: 361 STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 407
                          TVSILEQRLTLTEDKLKQCLENQQLIMQRATP
Sbjct: 328 ---------------TVSILEQRLTLTEDKLKQCLENQQLIMQRATP 359


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  424 bits (1090), Expect = e-119
 Identities = 199/334 (59%), Positives = 258/334 (77%), Gaps = 12/334 (3%)

Query: 3   APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
           A   EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 2   ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61

Query: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
            VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ   TAS
Sbjct: 62  VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121

Query: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
           +DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181

Query: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
           + +  GF  +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS  VN +SFHPSGN
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241

Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
           YLITASSD TLKILDL+EGRL+YTL GH GP  TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301

Query: 303 DIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 336
           D +    +TK             NL  + F  PP
Sbjct: 302 DELHCKGLTK------------RNLKRLHFDSPP 323


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  162 bits (410), Expect = 5e-40
 Identities = 88/285 (30%), Positives = 143/285 (50%), Gaps = 1/285 (0%)

Query: 16  KGHRDAVTCVDFSINT-KQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           +GHR+ V  + F+     ++A+GS D    +W ++     + F GH   + C++F+P   
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           L+A+GS D T ++W      E    R H+A + S+ F + G   +T S D TV VW    
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
            + +  L  H   +  A F+ D  LI++ S DKT KLWD ++ +CV +   H   +    
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
           F  +G  IA A  D T +++   T + +   + H   ++ +SF+P GN+L+T SSD T +
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370

Query: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
           I D   G+ L  L GH     + AF+  G    +G  D    +W+
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score =  139 bits (351), Expect = 4e-33
 Identities = 70/241 (29%), Positives = 126/241 (52%)

Query: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           F+GH   + C+ F+  +  +A+GSMD+   +W ++     Y   GH   +  ++F+ SG 
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
            + +GS D TV +W  +   +  +   H A + S  F  D    +T S DKT K+W    
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
            K + +L+ H + +  + F   G+LI +AS D T +++  ++R+C+     H G ++ + 
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
           F+P G  +     D T ++WD +T + LQ  + H+  +   +F+  GN +IT S D+T +
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412

Query: 255 I 255
           I
Sbjct: 413 I 413



 Score =  117 bits (292), Expect = 2e-26
 Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)

Query: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 122
           +T V  + SG    +GS D+T ++W      E      H   V ++ F +  G    T S
Sbjct: 95  LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154

Query: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
            DKT K+W+    K   +   H   + C  F+P   L+ + S D T KLWD  + E V++
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214

Query: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
              H   +  + F+ SG  I     D+TV VWD  T R +     H A ++  SF+   +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274

Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
            ++T S D T K+ D   G+ + TL GH        F  TG+  A+  +D    ++ +
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332



 Score =  116 bits (291), Expect = 3e-26
 Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)

Query: 98  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 156
           V +AH   + +V     G  F+T S D+T K+W T   + L +L  H N V    F +P 
Sbjct: 87  VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146

Query: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
           G  I + S DKT KLW   + +C H++  H   +  + F+P  T +A   MD T K+WD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206

Query: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
           +    +   + HSA +  LSF+ SG+ +IT S D T+ + D   GR +  L GH    ++
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266

Query: 277 VAFSRTGEYFASGGSDEQVMVW 298
            +F+       +G  D+   +W
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLW 288



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)

Query: 116 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 164
           +  +TAS  + VK+     Q+          +LF  L  HI  +     +  G   ++ S
Sbjct: 52  EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111

Query: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
            D+T KLWD +S E +++   H   V  + F+ P G  IA    D T K+W V T +   
Sbjct: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171

Query: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
            ++ H+A +  LSF+P    + T S D+T K+ D+  G  +YTL GH     +++F+ +G
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231

Query: 284 EYFASGGSDEQVMVWKSN 301
           +   +G  D  V+VW ++
Sbjct: 232 DRIITGSFDHTVVVWDAD 249


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  157 bits (397), Expect = 2e-38
 Identities = 93/305 (30%), Positives = 145/305 (47%), Gaps = 24/305 (7%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GHR  VT V F      + S S D+ + VW  +         GH D+V  ++F  SG LL
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165

Query: 77  ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           AS S D T+++W  + +G   +     H   V SV    +G   V+AS DKT+K+W    
Sbjct: 166 ASCSADMTIKLW--DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
              + + + H  WVR  + + DG LI S S+D+TV++W  +++EC     EH   V  + 
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283

Query: 195 FHPS--------------------GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
           + P                     G  + +   D T+K+WDV T   L     H   V G
Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343

Query: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
           + FH  G ++++ + D TL++ D    R + TL+ H+   T++ F +T  Y  +G  D+ 
Sbjct: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403

Query: 295 VMVWK 299
           V VW+
Sbjct: 404 VKVWE 408



 Score =  141 bits (355), Expect = 1e-33
 Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 20/269 (7%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           E    ER  KGH D+V  + F  + K LAS S D  + +W  +         GH   V+ 
Sbjct: 138 ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V   P+G  + S SRDKT+++W          F  H   VR V    DG    + S+D+T
Sbjct: 198 VAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--------------------GRLIVSASDD 166
           V+VW    ++    L +H + V C  ++P+                    G  ++S S D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317

Query: 167 KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
           KT+K+WD S+  C+ +   H  +V  V FH  G  I +   D T++VWD +  R ++   
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377

Query: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKI 255
            H   V  L FH +  Y++T S D T+K+
Sbjct: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406



 Score =  130 bits (327), Expect = 2e-30
 Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)

Query: 46  WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 105
           W  +P  + Y  +GH+  VT V F P   ++ S S D T+++W           + HT +
Sbjct: 94  WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152

Query: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
           V+ + F   G+   + S D T+K+W     + + ++  H + V      P+G  IVSAS 
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212

Query: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
           DKT+K+W+  +  CV ++  H  +V  V  +  GT IA+   D TV+VW V T       
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272

Query: 226 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 265
           + H   V  +S+ P  +Y                    L++ S D T+K+ D+  G  L 
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332

Query: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           TL GH      V F   G++  S   D+ + VW
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365



 Score =  125 bits (313), Expect = 9e-29
 Identities = 70/225 (31%), Positives = 105/225 (46%), Gaps = 20/225 (8%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           R   GH   V+ V    N   + S S D  + +W ++       FTGH++ V  V  +  
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD------------------ 114
           G L+AS S D+TVR+WV   K      R H   V  + +  +                  
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305

Query: 115 --GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
             G   ++ S DKT+K+W       L +L  H NWVR   F   G+ I+S +DDKT+++W
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365

Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           D  ++ C+ +   H  FVT +DFH +   +    +D TVKVW+ R
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)

Query: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
           H   VT V FHP  + + +A  D T+KVWD  T    +  + H+ +V  +SF  SG  L 
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166

Query: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 302
           + S+D T+K+ D      + T+HGH    ++VA    G++  S   D+ + +W+      
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226

Query: 303 --DIVDHGEVTKVPRP--PATLASSMGN 326
                 H E  ++ RP    TL +S  N
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  156 bits (394), Expect = 4e-38
 Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)

Query: 59  GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
           GH +AV+ V FSP+G  LAS S D+ + IW   + K E T++  H   +  V + SD   
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97

Query: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
            V+ASDDKT+K+W     K L +L  H N+V C  F+P   LI+S S D+TVK+W+  + 
Sbjct: 98  LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLS 236
           +C+ +   H   V+ V F+ SG+ I +   D   ++WD  + + L+      +  V+ + 
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217

Query: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 293
           F P+G Y++TA+ D+TLK+ D   GR L T  GH+     +   FS T G++  SG  D 
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277

Query: 294 QVMVW 298
            V +W
Sbjct: 278 LVYIW 282



 Score =  130 bits (326), Expect = 3e-30
 Identities = 86/291 (29%), Positives = 138/291 (47%), Gaps = 6/291 (2%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH +AV+ V FS N + LAS S D  +++W            GH   ++ V +S     L
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            S S DKT+++W           + H+  V   +F       ++ S D+TVK+W     K
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158

Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG-FVTYVDF 195
            L +LS H + V    F+  G LIVS S D   ++WD +S +C+ +  +     V++V F
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218

Query: 196 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS---GNYLITASSDST 252
            P+G  I  A +DNT+K+WD    R L+ Y  H      +  + S   G ++++ S D+ 
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278

Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMVWKSN 301
           + I +L    ++  L GH     + A   T    AS    +D+ + +W SN
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329



 Score =  130 bits (326), Expect = 3e-30
 Identities = 80/256 (31%), Positives = 130/256 (50%), Gaps = 6/256 (2%)

Query: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
           A D   E+   GH   ++ V +S ++ +L S S D  L +W ++         GH + V 
Sbjct: 70  AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129

Query: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
           C NF+P  +L+ SGS D+TV+IW            AH+  V +VHF   G   V+ S D 
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189

Query: 126 TVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
             ++W     + L +L    N  V   KFSP+G+ I++A+ D T+KLWD S   C+ +Y 
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249

Query: 185 EHGG--FVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
            H    +  + +F    G  I +   DN V +W+++T  ++Q  Q H+  V   + HP+ 
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309

Query: 242 NYLITAS--SDSTLKI 255
           N + +A+  +D T+K+
Sbjct: 310 NLIASAALENDKTIKL 325



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 48/159 (30%), Positives = 81/159 (50%)

Query: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
           +L  H   V   KFSP+G  + S+S D+ + +W     +   +   H   ++ V +    
Sbjct: 36  TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95

Query: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
           + + +A  D T+K+WDVR+ + L+  + HS  V   +F+P  N +I+ S D T+KI ++ 
Sbjct: 96  SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155

Query: 260 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
            G+ L TL  H  P + V F+ +G    SG  D    +W
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 34/142 (23%), Positives = 69/142 (48%)

Query: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           +L +S+S +++ ++ +  +     +   H   V+ V F P+G  +A++  D  + +W   
Sbjct: 12  QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71

Query: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
             +  +    H+  ++ +++    + L++AS D TLK+ D+  G+ L TL GH       
Sbjct: 72  DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131

Query: 278 AFSRTGEYFASGGSDEQVMVWK 299
            F+       SG  DE V +W+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWE 153


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  136 bits (342), Expect = 4e-32
 Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)

Query: 4   PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
           P   + +L+    GH  AV+ V FS N + LAS S D  + +W           +GHK  
Sbjct: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89

Query: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
           ++ V +S   +LL S S DKT++IW  +        + H+  V   +F       V+ S 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
           D++V++W     K L +L  H + V    F+ DG LIVS+S D   ++WD +S +C+ + 
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209

Query: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
            +     V++V F P+G  I AA +DNT+K+WD    + L+ Y  H      +  + S  
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
            G ++++ S D+ + I +L    ++  L GH     + A   T    AS    +D+ + +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329

Query: 298 WKSN 301
           WKS+
Sbjct: 330 WKSD 333


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  136 bits (342), Expect = 4e-32
 Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)

Query: 4   PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
           P   + +L+    GH  AV+ V FS N + LAS S D  + +W           +GHK  
Sbjct: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89

Query: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
           ++ V +S   +LL S S DKT++IW  +        + H+  V   +F       V+ S 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
           D++V++W     K L +L  H + V    F+ DG LIVS+S D   ++WD +S +C+ + 
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209

Query: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
            +     V++V F P+G  I AA +DNT+K+WD    + L+ Y  H      +  + S  
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
            G ++++ S D+ + I +L    ++  L GH     + A   T    AS    +D+ + +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329

Query: 298 WKSN 301
           WKS+
Sbjct: 330 WKSD 333


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  132 bits (332), Expect = 6e-31
 Identities = 91/297 (30%), Positives = 137/297 (46%), Gaps = 3/297 (1%)

Query: 3   APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
           +P   D  L+  F+ H   V+CV    +   L S   D    V  +   +      GH D
Sbjct: 336 SPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD 395

Query: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTA 121
            ++   F PSG  LA+ S D TV++W    KG+  + F  H+  V S  + S G    ++
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454

Query: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
           S DKT K+W  + ++   +L  H + V   +F P    ++++S DKT+ +WD  +  C  
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514

Query: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
           S   H   +    F P G  IA+       K+WD R    +    +  +  N ++F  SG
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574

Query: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
             L  AS +  + +LDL  G  ++ L GH+  A TV FS  GE   SGGSD  V  W
Sbjct: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 42/159 (26%), Positives = 76/159 (47%)

Query: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
           V C    P   ++VS  +D+  K+        + +   H  +++   FHPSG  +A +  
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414

Query: 208 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
           D TVK+WD+     +  ++ HS AV   ++H  GN++ ++S D T KI D+   R   TL
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474

Query: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
           +GH     ++ F        +  +D+ + +W +   I +
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 32/156 (20%), Positives = 51/156 (32%), Gaps = 41/156 (26%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH D+V  ++F   +  L + S D  L +W  +         GH  ++    F P GH++
Sbjct: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535

Query: 77  ASGSRDKTVRIW-----VPNVK------------------------------------GE 95
           AS       ++W     +P V                                     GE
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE 595

Query: 96  STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
                 H     +V F  DG+   +   D TV+ W+
Sbjct: 596 IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  130 bits (328), Expect = 2e-30
 Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)

Query: 16  KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           KGH D  +TC+ F  N  ++ SGS D+ L VW            GH   V       +  
Sbjct: 259 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 314

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           ++ SGS D+T+++W             HT+TVR +H     +  V+ S D T++VW    
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 372

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
            + L  L  H+  VRC ++  DGR +VS + D  VK+WD  +  C+H+   H   V  + 
Sbjct: 373 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
           F   G  + +  +D +++VWDV T   +     H +  +G+      N L++ ++DST+K
Sbjct: 431 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 486

Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           I D+  G+ L TL G   HQ   T + F++   +  +   D  V +W
Sbjct: 487 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 531



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH   V C+   ++ K++ SGS D+ L VW ++     +   GH  AV CV +   G  +
Sbjct: 341 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 396

Query: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            SG+ D  V++W P  +      + HT  V S+ F  DG   V+ S D +++VW      
Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 454

Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
            + +L+ H +     +   +  ++VS + D TVK+WD  + +C+ +     +H   VT +
Sbjct: 455 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512

Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
            F+ +   +  +  D TVK+WD++T   +++
Sbjct: 513 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 541


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  130 bits (328), Expect = 2e-30
 Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)

Query: 16  KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           KGH D  +TC+ F  N  ++ SGS D+ L VW            GH   V       +  
Sbjct: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           ++ SGS D+T+++W             HT+TVR +H     +  V+ S D T++VW    
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
            + L  L  H+  VRC ++  DGR +VS + D  VK+WD  +  C+H+   H   V  + 
Sbjct: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
           F   G  + +  +D +++VWDV T   +     H +  +G+      N L++ ++DST+K
Sbjct: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604

Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           I D+  G+ L TL G   HQ   T + F++   +  +   D  V +W
Sbjct: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH   V C+   ++ K++ SGS D+ L VW ++     +   GH  AV CV +   G  +
Sbjct: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514

Query: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            SG+ D  V++W P  +      + HT  V S+ F  DG   V+ S D +++VW      
Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572

Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
            + +L+ H +     +   +  ++VS + D TVK+WD  + +C+ +     +H   VT +
Sbjct: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630

Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
            F+ +   +  +  D TVK+WD++T   +++
Sbjct: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  130 bits (328), Expect = 2e-30
 Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)

Query: 16  KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           KGH D  +TC+ F  N  ++ SGS D+ L VW            GH   V       +  
Sbjct: 297 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 352

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           ++ SGS D+T+++W             HT+TVR +H     +  V+ S D T++VW    
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 410

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
            + L  L  H+  VRC ++  DGR +VS + D  VK+WD  +  C+H+   H   V  + 
Sbjct: 411 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
           F   G  + +  +D +++VWDV T   +     H +  +G+      N L++ ++DST+K
Sbjct: 469 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 524

Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           I D+  G+ L TL G   HQ   T + F++   +  +   D  V +W
Sbjct: 525 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 569



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH   V C+   ++ K++ SGS D+ L VW ++     +   GH  AV CV +   G  +
Sbjct: 379 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 434

Query: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            SG+ D  V++W P  +      + HT  V S+ F  DG   V+ S D +++VW      
Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 492

Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
            + +L+ H +     +   +  ++VS + D TVK+WD  + +C+ +     +H   VT +
Sbjct: 493 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550

Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
            F+ +   +  +  D TVK+WD++T   +++
Sbjct: 551 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 579


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  130 bits (327), Expect = 2e-30
 Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 52/337 (15%)

Query: 14  HF--KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF- 69
           HF  KGHR  V  + +S + ++LASG  +  +++W      +  R   GH   +T +++ 
Sbjct: 149 HFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE 208

Query: 70  ----SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
               +P    +AS S+D +VRIW         +   HT +V  + +  DG  + +AS D+
Sbjct: 209 PLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDR 267

Query: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-------------------------- 159
           T+KVW  H      +L  H +WV     S D  L                          
Sbjct: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327

Query: 160 ----------------IVSASDDKTVKLWDKSS-RECVHSYCEHGGFVTYVDFHPSGTCI 202
                           +VS SDD T+ LW  +  ++ +     H   +  V F P    +
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387

Query: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
           A+A  D ++K+WD RT + L   + H AAV  +++      L++ SSDSTLK+ D+   +
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447

Query: 263 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
           L   L GH      V +S  G+  ASGG D+ + +W+
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484



 Score =  106 bits (265), Expect = 3e-23
 Identities = 81/332 (24%), Positives = 137/332 (41%), Gaps = 50/332 (15%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
           +GH +AV  V FS   K LASGS D+ +  W +  ++  +   GH+  V  +++SP G  
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170

Query: 76  LASGSRDKTVRIWVPNV-KGESTVFRAHTATV-----RSVHFCSDGQSFVTASDDKTVKV 129
           LASG ++  + +W P+  K        H+  +       +H   + +   ++S D +V++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230

Query: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
           W T   +    L+ H   V C ++  DG L+ SAS D+T+K+W         +   HG +
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289

Query: 190 VTYV-----------DFHPSGTCI-------------------------------AAAGM 207
           V  +            F P+   +                                +   
Sbjct: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349

Query: 208 DNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
           D T+ +W      + L     H A +N + F P    + +AS D ++K+ D   G+ L +
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409

Query: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           L GH      +A+S       SG SD  + VW
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)

Query: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 198
           SL  H   V    FSP G+ + S S D TV+ WD S+ E  H  C+ H  +V  + + P 
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167

Query: 199 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 252
           G  +A+   +  + +WD  T + + +    HS  + GLS+     +P   Y+ ++S D +
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227

Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
           ++I D   GR    L GH    T + +   G  + S   D  + VW+++
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 35/125 (28%), Positives = 57/125 (45%)

Query: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
           AED        GH+  +  V FS +++ +AS S D  + +W  +         GH  AV 
Sbjct: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418

Query: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
            + +S    LL SGS D T+++W    +  +     H   V +V +  DGQ   +   DK
Sbjct: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478

Query: 126 TVKVW 130
            +++W
Sbjct: 479 CLRIW 483



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)

Query: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
           C  S   H   V  V F P+G  +A+   D TV+ WD+ T       + H   V  +S+ 
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165

Query: 239 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 292
           P G  L +   +  + + D   G+ +  TL GH    T +++     +    Y AS   D
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225

Query: 293 EQVMVW 298
             V +W
Sbjct: 226 GSVRIW 231



 Score = 36.6 bits (83), Expect = 0.042
 Identities = 17/37 (45%), Positives = 20/37 (54%)

Query: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
           R   +L GH     +VAFS TG+Y ASG  D  V  W
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  129 bits (323), Expect = 6e-30
 Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)

Query: 72  SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
           SG LLA+G  D  V +W  N          HT+ V SV   +  +  V  S   +++VW 
Sbjct: 32  SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91

Query: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
               K L +L  H   +    F P G  + S S D  +KLWD   + CV  Y  H   V 
Sbjct: 92  LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151

Query: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
            + F P G  +A+A  D+TVK+WD+   +++  +  H+  VN + FHP+   L + SSD 
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211

Query: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 305
           T++  DL + +++  + G  GP  +V F+  G    SG  D  +V  W+    FD+V
Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268



 Score =  124 bits (312), Expect = 1e-28
 Identities = 64/218 (29%), Positives = 107/218 (49%)

Query: 34  LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
           LA+G  D  + +W +   +     TGH   V  V  +    L+ +GS+  ++R+W     
Sbjct: 36  LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95

Query: 94  GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 153
                   H A + S+ F   G+   + S D  +K+W   R+  +F    H   VRC +F
Sbjct: 96  KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155

Query: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
           SPDG+ + SA+DD TVKLWD ++ + +  +  H G V  V+FHP+   +A+   D T++ 
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215

Query: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
           WD+   +++   +     V  + F+P G  L +   DS
Sbjct: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253



 Score =  122 bits (306), Expect = 6e-28
 Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 101 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
           AH + V S+    + G+   T  DD  V +W+ ++   + SL+ H + V   + +    L
Sbjct: 18  AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77

Query: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
           IV+ S   ++++WD  + + + +   H   +  +DFHP G  +A+   D  +K+WD+R  
Sbjct: 78  IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137

Query: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
             +  Y+ HS AV  L F P G +L +A+ D T+K+ DL  G+++    GH GP   V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197

Query: 280 SRTGEYFASGGSDEQVMVW 298
                  ASG SD  +  W
Sbjct: 198 HPNEYLLASGSSDRTIRFW 216



 Score =  107 bits (267), Expect = 2e-23
 Identities = 58/201 (28%), Positives = 93/201 (46%)

Query: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68
           P+      GH   V  V  +   + + +GS    + VW ++         GHK  +  ++
Sbjct: 53  PNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112

Query: 69  FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
           F P G  +ASGS+D  +++W    KG    +R H+  VR + F  DG+   +A+DD TVK
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172

Query: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
           +W     K +     H   V   +F P+  L+ S S D+T++ WD    + V       G
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232

Query: 189 FVTYVDFHPSGTCIAAAGMDN 209
            V  V F+P G C+ +   D+
Sbjct: 233 PVRSVLFNPDGCCLYSGCQDS 253



 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 47/160 (29%), Positives = 77/160 (48%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           E   + R   GH+  +  +DF    + +ASGS D+ + +W ++ +   +R+ GH  AV C
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           + FSP G  LAS + D TV++W        + F  HT  V  V F  +     + S D+T
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166
           ++ W   + + +  +      VR   F+PDG  + S   D
Sbjct: 213 IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  128 bits (321), Expect = 1e-29
 Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75
           GH   V C  F  N   LAS   D  +++W++      Y    GH  AV  ++++  G +
Sbjct: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123

Query: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134
           L S S DKTV +W           + HT+ V S +    G   V T SDD TVK+W   R
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
           +K      Q+   V    F+     I+S   D  +K+WD    +  ++   H   VT + 
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246
               G+ + +  MDNTV+VWDVR      R ++ +Q  +H+   N L  S+ P G+ +  
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
            S+D  + + D    R+LY L GH G    VAF        S  SD+++
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351



 Score =  124 bits (312), Expect = 1e-28
 Identities = 76/257 (29%), Positives = 130/257 (50%), Gaps = 23/257 (8%)

Query: 58  TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114
           +GH+  V C  F P+G  LAS   D+ + +W  NV G+       + H+  V  +H+ +D
Sbjct: 63  SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120

Query: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173
           G    +AS DKTV VW +   + +  L  H ++V  C       +L+ + SDD TVKLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180

Query: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
              +  + ++ ++   V  V F+ +   I + G+DN +KVWD+R ++L    + H+ +V 
Sbjct: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239

Query: 234 GLSFHPSGNYLITASSDSTLKILD------------LMEGRLLYTLHGHQGPATTVAFSR 281
           GLS    G+YL++ + D+T+++ D            + +G     +H  +      ++S 
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG----NVHNFEKNLLRCSWSP 295

Query: 282 TGEYFASGGSDEQVMVW 298
            G   A+G +D  V VW
Sbjct: 296 DGSKIAAGSADRFVYVW 312



 Score =  108 bits (269), Expect = 1e-23
 Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74
           KGH  AV  + ++ +   L S S D  + VW  +   R  R  GH   V +C        
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
           L+ +GS D TV++W    K     F+ +T  V +V F       ++   D  +KVW   +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183
            K  +++  H + V     S +G  ++S + D TV++WD           K  +  VH++
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284

Query: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
            ++   +    + P G+ IAA   D  V VWD  + R+L     H+ ++N ++FHP    
Sbjct: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341

Query: 244 LITASSDSTL 253
           +I+ASSD  L
Sbjct: 342 IISASSDKRL 351



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 56/202 (27%), Positives = 83/202 (41%), Gaps = 45/202 (22%)

Query: 141 LSQHINWVRCAKFSP-------------------------------------------DG 157
           LS H   V C KF P                                           DG
Sbjct: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121

Query: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN-TVKVWDV 216
            ++ SAS DKTV +WD  + E V     H  FV        G  +   G D+ TVK+WD+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181

Query: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
           R    +Q +Q ++  V  ++F+ + + +I+   D+ +K+ DL + +L YT+ GH    T 
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240

Query: 277 VAFSRTGEYFASGGSDEQVMVW 298
           ++ S  G Y  S   D  V VW
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVW 262



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286
           H   V    FHP+G+ L +A  D  + + ++      Y TL GH G    + ++  G   
Sbjct: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124

Query: 287 ASGGSDEQVMVWKS 300
            S  +D+ V VW S
Sbjct: 125 FSASTDKTVAVWDS 138


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  126 bits (317), Expect = 3e-29
 Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)

Query: 55  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114
           Y F      +T V+ +    L+A G  D TVR+W    K            +RSV   SD
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512

Query: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
                  SDD   ++        L  L  H   V  A FSPD   ++S+S+D TV+LW  
Sbjct: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572

Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
            +  C+  Y  H   V    F P G    + G D   ++W    ++ L+ +  H A VN 
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632

Query: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
             FHP+ NY+ T S+D T+++ D++ G  +    GH+GP  ++ FS  G + A+G +D +
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692

Query: 295 VMVW 298
           V++W
Sbjct: 693 VLLW 696



 Score =  124 bits (310), Expect = 2e-28
 Identities = 74/277 (26%), Positives = 122/277 (44%), Gaps = 11/277 (3%)

Query: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
           +T VD + ++  +A G  DS + VW + P+            +  V  +    L+   S 
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521

Query: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
           D   RI       E  +   H+  V    F  D    +++S+D TV++W+      L   
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
             H   V   +FSP G   VS   D+  +LW     + +  +  H   V    FHP+   
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641

Query: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
           +A    D TV++WDV     ++ +  H   ++ L+F P+G +L T ++D  + + D+  G
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701

Query: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
            ++  L GH     ++ FSR GE  ASG  D  V +W
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 57/199 (28%), Positives = 85/199 (42%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
           GH   V    FS +   L S S D  + +W ++  +    + GH   V    FSP G+  
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600

Query: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            SG  D+  R+W  +      +F  H A V    F  +     T S D+TV++W      
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660

Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196
            +   + H   +    FSP+GR + + + D  V LWD      V     H   V  + F 
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720

Query: 197 PSGTCIAAAGMDNTVKVWD 215
             G  +A+  MDNTV++WD
Sbjct: 721 RDGEILASGSMDNTVRLWD 739



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 49/159 (30%), Positives = 70/159 (44%)

Query: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
           +KGH   V    FS       SG  D    +W          F GH   V C  F P+ +
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640

Query: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
            +A+GS D+TVR+W         +F  H   + S+ F  +G+   T + D  V +W    
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700

Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
              +  L  H + V   +FS DG ++ S S D TV+LWD
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 41/118 (34%), Positives = 60/118 (50%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           R F GH   V C  F  N+  +A+GS D  + +W +   +    FTGHK  +  + FSP+
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
           G  LA+G+ D  V +W           + HT TV S+ F  DG+   + S D TV++W
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)

Query: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 227
           C +++      +T VD     + IA    D+TV+VW V   +L    Q            
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521

Query: 228 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
                               HS  V G SF P  NYL+++S D T+++  L     L   
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
            GH  P     FS  G YF SGG D    +W ++
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  125 bits (315), Expect = 5e-29
 Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           + F  H   V    FS + + L +GS D C+  W  +     +R  GH   V    FSP 
Sbjct: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
           GHL AS S D TVR+W         V + H  +V +V F  D +   +   DK V +W  
Sbjct: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134

Query: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189
              + L  L  H + ++ + FSP    + + S D TV +WD    +    H   E H   
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194

Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
           ++ + +  SG  +A+   D T+ +W   T  LL   + H   V  ++F P   +L +A  
Sbjct: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253

Query: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
              +K+ D   G+ L TL G    A T AF+  G+   SG +D+
Sbjct: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score =  125 bits (313), Expect = 9e-29
 Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)

Query: 53  RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109
           R  +F G H   V    FSP G +L +GS D  V  W    +    ++R   HT  V+  
Sbjct: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69

Query: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
            F  DG  F +AS D TV++W   R K L  L  H   V    FSPD R + S   DK V
Sbjct: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129

Query: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223
            LWD  S + +     H   +   DF P+  C+A    D+TV +WD+R      +H+ L+
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189

Query: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
               HSA ++ L +  SG  L + S D T+ I       LL  L GH     ++AFS   
Sbjct: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245

Query: 284 EYFASGGSDEQVMVWKSN 301
            + AS G    V VW  N
Sbjct: 246 LWLASAGYSRMVKVWDCN 263



 Score =  108 bits (271), Expect = 7e-24
 Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           R  KGH+ +V  V FS +++QLASG  D  +M+W ++         GH+D++   +FSP+
Sbjct: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158

Query: 73  GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
            + LA+GS D TV IW      P V  ++     H+A +  + + + G    + S DKT+
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215

Query: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
            +W       L  L  H+ WV+   FSPD   + SA   + VK+WD ++ +C+ +     
Sbjct: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275

Query: 188 GFVTYVDFHPSGTCIAAAGMDNT 210
                  F P G  + +   D T
Sbjct: 276 DVAHTCAFTPDGKILVSGAADQT 298



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)

Query: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73
           GHRD++   DFS     LA+GS DS + +W ++   P        GH   ++C+ +S SG
Sbjct: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204

Query: 74  HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
            LLASGS DKT+ IW P         + H   V+S+ F  D     +A   + VKVW  +
Sbjct: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263

Query: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
             K L +L   ++      F+PDG+++VS + D+T +   ++S+
Sbjct: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307



 Score = 35.8 bits (81), Expect = 0.072
 Identities = 24/77 (31%), Positives = 31/77 (40%)

Query: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
           SL    KGH   V  + FS +   LAS      + VW            G  D      F
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283

Query: 70  SPSGHLLASGSRDKTVR 86
           +P G +L SG+ D+T R
Sbjct: 284 TPDGKILVSGAADQTRR 300


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score =  125 bits (313), Expect = 9e-29
 Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           R  KGH + V C+D+  + +++ S S D  ++VW     ++ +  T     V    ++PS
Sbjct: 57  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116

Query: 73  GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           G  +A G  D    ++        N+  +      HT  + +  F +     +TAS D T
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
             +W     + L S   H   V C   +P   G   VS   DK   +WD  S +CV ++ 
Sbjct: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236

Query: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
            H   +  V ++PSG   A+   D T +++D+R  R +  Y   S     + + F  SG 
Sbjct: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 296

Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
            L    +D T+ + D+++G  +  L GH+   +T+  S  G  F SG  D  + VW
Sbjct: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 45/171 (26%), Positives = 60/171 (35%), Gaps = 46/171 (26%)

Query: 7   EDPSLERHFKGHRDAVTCVDF--SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
           E   L + F GH   V C+D   S       SG  D   MVW M+       F  H+  +
Sbjct: 183 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 242

Query: 65  TCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRA---------------- 101
             V + PSG   ASGS D T R++       V     ES +F A                
Sbjct: 243 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 302

Query: 102 ---------------------HTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
                                H   V ++    DG +F + S D T++VWA
Sbjct: 303 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score =  125 bits (313), Expect = 9e-29
 Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)

Query: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
           R  KGH + V C+D+  + +++ S S D  ++VW     ++ +  T     V    ++PS
Sbjct: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158

Query: 73  GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           G  +A G  D    ++        N+  +      HT  + +  F +     +TAS D T
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
             +W     + L S   H   V C   +P   G   VS   DK   +WD  S +CV ++ 
Sbjct: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278

Query: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
            H   +  V ++PSG   A+   D T +++D+R  R +  Y   S     + + F  SG 
Sbjct: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 338

Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
            L    +D T+ + D+++G  +  L GH+   +T+  S  G  F SG  D  + VW
Sbjct: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 45/171 (26%), Positives = 60/171 (35%), Gaps = 46/171 (26%)

Query: 7   EDPSLERHFKGHRDAVTCVDF--SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
           E   L + F GH   V C+D   S       SG  D   MVW M+       F  H+  +
Sbjct: 225 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 284

Query: 65  TCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRA---------------- 101
             V + PSG   ASGS D T R++       V     ES +F A                
Sbjct: 285 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 344

Query: 102 ---------------------HTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
                                H   V ++    DG +F + S D T++VWA
Sbjct: 345 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score =  117 bits (292), Expect = 2e-26
 Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 7/270 (2%)

Query: 30  NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88
           +T ++ +G  D  ++V+    +       GH   VT V F PS  L+ S S D T+RIW 
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292

Query: 89  VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW- 147
           VPN      V RAH + V  +   + G   +++SDD+          + L  ++   +  
Sbjct: 293 VPNASCVQVV-RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351

Query: 148 -VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
            + CA+F PDG +  + + D  +K+WD   R  V ++  H G +T + F  +G  +A A 
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411

Query: 207 MDNTVKVWDVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
            D++VK+WD+R  +  +  QL ++  V  L F  SG YL    +D  + I       L +
Sbjct: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHF 471

Query: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
           T   H G  T VAF    ++ AS G D  +
Sbjct: 472 T--EHSGLTTGVAFGHHAKFIASTGMDRSL 499



 Score =  100 bits (249), Expect = 2e-21
 Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)

Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
           SD    +T   DK V V+    ++ L +L  H   V    F P   L+ SAS D T+++W
Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291

Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 230
              +  CV     H   VT +  H +G  + ++  D      D++T R+L     +    
Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351

Query: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
           ++    FHP G    T + DS +KI DL E   +    GH GP T++AFS  G Y A+  
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411

Query: 291 SDEQVMVW 298
            D  V +W
Sbjct: 412 DDSSVKLW 419



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 60/242 (24%), Positives = 111/242 (45%), Gaps = 6/242 (2%)

Query: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
           + +G  DK V ++  + +      + HT  V SV F        +AS D T+++W+    
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296

Query: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH--GGFVTYV 193
             +  +  H + V        G  ++S+SDD+     D  +   +    +   G  +T  
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356

Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
            FHP G       MD+ +K+WD++    + ++  HS  +  ++F  +G YL TA+ DS++
Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416

Query: 254 KILDLMEGRLLYTLH-GHQGPATTVAFSRTGEYFASGGSDEQVMV---WKSNFDIVDHGE 309
           K+ DL + +   TL   +     ++ F ++G Y A GG+D Q+ +   W       +H  
Sbjct: 417 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSG 476

Query: 310 VT 311
           +T
Sbjct: 477 LT 478



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 63/249 (25%), Positives = 105/249 (42%), Gaps = 11/249 (4%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
           KGH   VT V F  +   + S S D+ + +W +   S       H+ AVT ++   +G  
Sbjct: 261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 320

Query: 76  LASGSRDKTVRIWVPNVKGESTVFRAHT-----ATVRSVHFCSDGQSFVTASDDKTVKVW 130
           L S S D   + W  +      V    T      ++    F  DG  F T + D  +K+W
Sbjct: 321 LLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW 377

Query: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF- 189
               +  + +   H   +    FS +G  + +A+DD +VKLWD    +   +      F 
Sbjct: 378 DLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE 437

Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
           V  + F  SGT +A  G D  V+++  +    + H+  HS    G++F     ++ +   
Sbjct: 438 VKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM 495

Query: 250 DSTLKILDL 258
           D +LK   L
Sbjct: 496 DRSLKFYSL 504



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 3/119 (2%)

Query: 14  HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPS 72
           +F GH   +T + FS N   LA+ + DS + +W ++           +   V  + F  S
Sbjct: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
           G  LA G  D  V+I++     E   F  H+     V F    +   +   D+++K ++
Sbjct: 447 GTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  117 bits (292), Expect = 2e-26
 Identities = 77/285 (27%), Positives = 126/285 (44%), Gaps = 12/285 (4%)

Query: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
           VT +D++     LA+GS D    +W  K  + A     HK  +  + ++  G+ + S   
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286

Query: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
           DKT  IW  +       F  H+A    V + S+  +F + S D  + V    + + + + 
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIKTF 345

Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT- 200
             H N V   K+ P G L+ S SDD T+K+W      CVH    H   +  + + P+G  
Sbjct: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405

Query: 201 --------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
                    +A+A  D+TV++WDV     +     H   V  ++F P G YL + S D  
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465

Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
           + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCV 509



 Score =  110 bits (275), Expect = 2e-24
 Identities = 83/322 (25%), Positives = 145/322 (45%), Gaps = 39/322 (12%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA---------------YRFTGH 60
           +GH   V    ++  +  LASGS DS   +W++   S +                    +
Sbjct: 166 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSN 225

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KD VT ++++  G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 226 KD-VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQ-HKGPIFALKWNKKGNFILS 283

Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 284 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-------SCSTDMCIHVCKL 336

Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
                + ++  H   V  + + P+G  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 396

Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
           + + P+G           L +AS DST+++ D+  G  ++TL  HQ P  +VAFS  G Y
Sbjct: 397 IKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRY 456

Query: 286 FASGGSDEQVMVWKSNFDIVDH 307
            ASG  D+ V +W +    + H
Sbjct: 457 LASGSFDKCVHIWNTQTGALVH 478



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 15/217 (6%)

Query: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
           ++ F  H      VD+  N    AS S D C+ V  +        F GH + V  + + P
Sbjct: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359

Query: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
           +G+LLAS S D T++IW  ++K ++ V   +AH   + ++ +   G             +
Sbjct: 360 TGNLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           AS D TV++W   R   + +L++H   V    FSPDGR + S S DK V +W+  +   V
Sbjct: 418 ASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV 477

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           HSY   GG +  V ++ +G  + A+  D +V V D+R
Sbjct: 478 HSYRGTGG-IFEVCWNAAGDKVGASASDGSVCVLDLR 513



 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 61/261 (23%), Positives = 116/261 (44%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           +D +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 254 KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  S +  AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 314 VDWQ-SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 373 LKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG 432

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C+H+  +H   V  V F P G  +A+   D  V +W+ +T  L+  Y+  +  +  + +
Sbjct: 433 ICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVCW 491

Query: 238 HPSGNYLITASSDSTLKILDL 258
           + +G+ +  ++SD ++ +LDL
Sbjct: 492 NAAGDKVGASASDGSVCVLDL 512


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score =  116 bits (291), Expect = 3e-26
 Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)

Query: 57  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
           F  H   V  V FSP   LLA+G  D+ V++W   V GE   F+       A + S+ F 
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375

Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
           S G   + AS+D   ++W     +   +L+ H   V  AKF  D   IVS S D+T+KLW
Sbjct: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435

Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
           D  S+ C+ +        +  D   +  C+ +   D  ++ WD+R+  +++  +L    +
Sbjct: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491

Query: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
             L  +P    L++ S D  LK++DL    +  T            T V FS  G Y A+
Sbjct: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551

Query: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
           G ++  + +W      V  G+V KV
Sbjct: 552 GSAEGSLYIWS-----VLTGKVEKV 571



 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)

Query: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
           F  H   V  V FS  ++ LA+G MD  + +W +  +   ++   +G    +T + F  +
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
           G  L + S D   RIW  +          H+  V S  F  D    V+ S D+T+K+W  
Sbjct: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437

Query: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
             +   K +F+ S   N + C +     + ++S   DK ++ WD  S   V    E  G 
Sbjct: 438 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 490

Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
           +T +D +P  T + +   D+ +KV D+RT+ + Q +             + F P G+Y+ 
Sbjct: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550

Query: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
             S++ +L I  ++ G++   L   H      VA+S +G +  S     + ++W
Sbjct: 551 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 17/217 (7%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
           +D  L     GH   V    F ++  ++ SGS D  L +W ++ +      F G     +
Sbjct: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 451

Query: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH-TATVRSVHFCSDGQSFVTASDD 124
           C +   +   + SG  DK +R W  +++ ES V        + ++    +    ++ S D
Sbjct: 452 CNDIVCTEQCVMSGHFDKKIRFW--DIRSESIVREMELLGKITALDLNPERTELLSCSRD 509

Query: 125 KTVKV--WATHRQKFLFS---LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSR 177
             +KV    T+  K  FS        +W R   FSPDG  + + S + ++ +W       
Sbjct: 510 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGKV 568

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
           E V S  +H   +  V + PSG+ + +        +W
Sbjct: 569 EKVLSK-QHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score =  116 bits (291), Expect = 3e-26
 Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)

Query: 57  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
           F  H   V  V FSP   LLA+G  D+ V++W   V GE   F+       A + S+ F 
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 356

Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
           S G   + AS+D   ++W     +   +L+ H   V  AKF  D   IVS S D+T+KLW
Sbjct: 357 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416

Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
           D  S+ C+ +        +  D   +  C+ +   D  ++ WD+R+  +++  +L    +
Sbjct: 417 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 472

Query: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
             L  +P    L++ S D  LK++DL    +  T            T V FS  G Y A+
Sbjct: 473 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 532

Query: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
           G ++  + +W      V  G+V KV
Sbjct: 533 GSAEGSLYIWS-----VLTGKVEKV 552



 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)

Query: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
           F  H   V  V FS  ++ LA+G MD  + +W +  +   ++   +G    +T + F  +
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 358

Query: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
           G  L + S D   RIW  +          H+  V S  F  D    V+ S D+T+K+W  
Sbjct: 359 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418

Query: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
             +   K +F+ S   N + C +     + ++S   DK ++ WD  S   V    E  G 
Sbjct: 419 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 471

Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
           +T +D +P  T + +   D+ +KV D+RT+ + Q +             + F P G+Y+ 
Sbjct: 472 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 531

Query: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
             S++ +L I  ++ G++   L   H      VA+S +G +  S     + ++W
Sbjct: 532 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 17/217 (7%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
           +D  L     GH   V    F ++  ++ SGS D  L +W ++ +      F G     +
Sbjct: 377 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 432

Query: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH-TATVRSVHFCSDGQSFVTASDD 124
           C +   +   + SG  DK +R W  +++ ES V        + ++    +    ++ S D
Sbjct: 433 CNDIVCTEQCVMSGHFDKKIRFW--DIRSESIVREMELLGKITALDLNPERTELLSCSRD 490

Query: 125 KTVKV--WATHRQKFLFS---LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSR 177
             +KV    T+  K  FS        +W R   FSPDG  + + S + ++ +W       
Sbjct: 491 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGKV 549

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
           E V S  +H   +  V + PSG+ + +        +W
Sbjct: 550 EKVLSK-QHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 3e-26
 Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)

Query: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
           P+     +GH   V    ++  +  LASGS DS   +W++   S             R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 59  GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
           GH     KD VT ++++  G LLA GS D   RIW  N    ST+ + H   + ++ +  
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286

Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
            G   ++A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D 
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339

Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
            + +        V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q 
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
           HS  +  + + P+G           L +AS DST+++ D+ +G   +TL  HQ P  +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459

Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
           FS  G+Y ASG  D+ V +W +    + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           E+ +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  YQ  +  +  + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 3e-26
 Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)

Query: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
           P+     +GH   V    ++  +  LASGS DS   +W++   S             R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 59  GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
           GH     KD VT ++++  G LLA GS D   RIW  N    ST+ + H   + ++ +  
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286

Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
            G   ++A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D 
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339

Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
            + +        V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q 
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
           HS  +  + + P+G           L +AS DST+++ D+ +G   +TL  HQ P  +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459

Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
           FS  G+Y ASG  D+ V +W +    + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           E+ +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  YQ  +  +  + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 3e-26
 Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)

Query: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
           P+     +GH   V    ++  +  LASGS DS   +W++   S             R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 59  GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
           GH     KD VT ++++  G LLA GS D   RIW  N    ST+ + H   + ++ +  
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286

Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
            G   ++A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D 
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339

Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
            + +        V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q 
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
           HS  +  + + P+G           L +AS DST+++ D+ +G   +TL  HQ P  +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459

Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
           FS  G+Y ASG  D+ V +W +    + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           E+ +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  YQ  +  +  + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  115 bits (287), Expect = 9e-26
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)

Query: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
           VT +D++ N   LA+GS D    +W  +  + A     HK  +  + ++  G+ + S   
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298

Query: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
           DKT  IW  +       F  H+A    V +  +  +F + S D  + V      + + + 
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 357

Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
             H N V   K+ P G L+ S SDD T+K+W      C+H    H   +  + + P+G  
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417

Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
                    +A+A  D+TV++WD+     TH L +H +     V  ++F P G YL + S
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 473

Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
            D  + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 474 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521



 Score =  113 bits (282), Expect = 4e-25
 Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
           +GH   V    ++  +  LASGS DS   +W++   S             R  GH     
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KD VT ++++ +G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 238 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 295

Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348

Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
                V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408

Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
           + + P+G           L +AS DST+++ D+  G   +TL  HQ P  +VAFS  G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468

Query: 286 FASGGSDEQVMVWKS 300
            ASG  D+ V +W +
Sbjct: 469 LASGSFDKCVHIWNT 483



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)

Query: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
           ++ F  H      VD+  NT   AS S D C+ V  +        F GH + V  + + P
Sbjct: 313 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371

Query: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
           SG LLAS S D T++IW  ++K E  +   +AH   + ++ +   G +           +
Sbjct: 372 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           AS D TV++W   R     +L++H   V    FSPDG+ + S S DK V +W+  S   V
Sbjct: 430 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 489

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           HSY   GG +  V ++  G  + A+  D +V V D+R
Sbjct: 490 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 525



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           ED +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 266 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 326 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  ++  +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 385 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  Y+  +  +  + +
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 503

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 504 NARGDKVGASASDGSVCVLDL 524


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  115 bits (287), Expect = 9e-26
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)

Query: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
           VT +D++ N   LA+GS D    +W  +  + A     HK  +  + ++  G+ + S   
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298

Query: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
           DKT  IW  +       F  H+A    V +  +  +F + S D  + V      + + + 
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 357

Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
             H N V   K+ P G L+ S SDD T+K+W      C+H    H   +  + + P+G  
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417

Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
                    +A+A  D+TV++WD+     TH L +H +     V  ++F P G YL + S
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 473

Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
            D  + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 474 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521



 Score =  113 bits (282), Expect = 4e-25
 Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
           +GH   V    ++  +  LASGS DS   +W++   S             R  GH     
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KD VT ++++ +G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 238 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 295

Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348

Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
                V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408

Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
           + + P+G           L +AS DST+++ D+  G   +TL  HQ P  +VAFS  G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468

Query: 286 FASGGSDEQVMVWKS 300
            ASG  D+ V +W +
Sbjct: 469 LASGSFDKCVHIWNT 483



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)

Query: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
           ++ F  H      VD+  NT   AS S D C+ V  +        F GH + V  + + P
Sbjct: 313 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371

Query: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
           SG LLAS S D T++IW  ++K E  +   +AH   + ++ +   G +           +
Sbjct: 372 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           AS D TV++W   R     +L++H   V    FSPDG+ + S S DK V +W+  S   V
Sbjct: 430 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 489

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           HSY   GG +  V ++  G  + A+  D +V V D+R
Sbjct: 490 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 525



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           ED +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 266 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 326 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  ++  +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 385 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  Y+  +  +  + +
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 503

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 504 NARGDKVGASASDGSVCVLDL 524


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  115 bits (287), Expect = 9e-26
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)

Query: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
           VT +D++ N   LA+GS D    +W  +  + A     HK  +  + ++  G+ + S   
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349

Query: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
           DKT  IW  +       F  H+A    V +  +  +F + S D  + V      + + + 
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408

Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
             H N V   K+ P G L+ S SDD T+K+W      C+H    H   +  + + P+G  
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468

Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
                    +A+A  D+TV++WD+     TH L +H +     V  ++F P G YL + S
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524

Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
            D  + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572



 Score =  113 bits (282), Expect = 4e-25
 Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)

Query: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
           +GH   V    ++  +  LASGS DS   +W++   S             R  GH     
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288

Query: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
           KD VT ++++ +G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346

Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399

Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
                V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459

Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
           + + P+G           L +AS DST+++ D+  G   +TL  HQ P  +VAFS  G+Y
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519

Query: 286 FASGGSDEQVMVWKS 300
            ASG  D+ V +W +
Sbjct: 520 LASGSFDKCVHIWNT 534



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)

Query: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
           ++ F  H      VD+  NT   AS S D C+ V  +        F GH + V  + + P
Sbjct: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422

Query: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
           SG LLAS S D T++IW  ++K E  +   +AH   + ++ +   G +           +
Sbjct: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480

Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
           AS D TV++W   R     +L++H   V    FSPDG+ + S S DK V +W+  S   V
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540

Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
           HSY   GG +  V ++  G  + A+  D +V V D+R
Sbjct: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)

Query: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
           ED +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376

Query: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435

Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
           +K+W+  ++  +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495

Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  Y+  +  +  + +
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554

Query: 238 HPSGNYLITASSDSTLKILDL 258
           +  G+ +  ++SD ++ +LDL
Sbjct: 555 NARGDKVGASASDGSVCVLDL 575


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.131    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,780,512
Number of Sequences: 37866
Number of extensions: 760876
Number of successful extensions: 6999
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 2383
Number of HSP's gapped (non-prelim): 1907
length of query: 407
length of database: 18,247,518
effective HSP length: 105
effective length of query: 302
effective length of database: 14,271,588
effective search space: 4310019576
effective search space used: 4310019576
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.