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Search of human proteins with 119964718
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
(999 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119964718 desmoglein 3 preproprotein [Homo sapiens] 1995 0.0
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens] 953 0.0
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens] 922 0.0
gi|119703744 desmoglein 1 preproprotein [Homo sapiens] 719 0.0
gi|116534898 desmoglein 2 preproprotein [Homo sapiens] 626 e-179
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 333 6e-91
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 317 5e-86
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 312 9e-85
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 298 1e-80
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 295 1e-79
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 291 3e-78
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 287 3e-77
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 285 1e-76
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 281 2e-75
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 276 5e-74
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 261 3e-69
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 237 4e-62
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 229 1e-59
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 186 9e-47
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 186 9e-47
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 181 3e-45
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 176 1e-43
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 174 4e-43
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 173 6e-43
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 168 3e-41
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 167 5e-41
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 165 2e-40
gi|16753221 cadherin 22 precursor [Homo sapiens] 164 3e-40
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 162 2e-39
gi|221316595 cadherin 17 precursor [Homo sapiens] 159 1e-38
>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
Length = 999
Score = 1995 bits (5168), Expect = 0.0
Identities = 999/999 (100%), Positives = 999/999 (100%)
Query: 1 MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCRE 60
MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCRE
Sbjct: 1 MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCRE 60
Query: 61 GEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREET 120
GEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREET
Sbjct: 61 GEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREET 120
Query: 121 PSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILN 180
PSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILN
Sbjct: 121 PSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILN 180
Query: 181 ATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGA 240
ATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGA
Sbjct: 181 ATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGA 240
Query: 241 DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN 300
DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN
Sbjct: 241 DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN 300
Query: 301 WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVI 360
WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVI
Sbjct: 301 WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVI 360
Query: 361 SRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAA 420
SRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAA
Sbjct: 361 SRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAA 420
Query: 421 SNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGT 480
SNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGT
Sbjct: 421 SNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGT 480
Query: 481 VYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWS 540
VYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWS
Sbjct: 481 VYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWS 540
Query: 541 ITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP 600
ITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP
Sbjct: 541 ITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP 600
Query: 601 TTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPD 660
TTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPD
Sbjct: 601 TTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPD 660
Query: 661 GSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGME 720
GSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGME
Sbjct: 661 GSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGME 720
Query: 721 MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA 780
MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA
Sbjct: 721 MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA 780
Query: 781 DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD 840
DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD
Sbjct: 781 DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD 840
Query: 841 LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQT 900
LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQT
Sbjct: 841 LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQT 900
Query: 901 LSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVI 960
LSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVI
Sbjct: 901 LSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVI 960
Query: 961 VTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI 999
VTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI
Sbjct: 961 VTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI 999
>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
Length = 1040
Score = 953 bits (2464), Expect = 0.0
Identities = 504/1005 (50%), Positives = 674/1005 (67%), Gaps = 58/1005 (5%)
Query: 4 LFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGED 63
LF R L I +VV+ V+ E +E K E T Q RRQKREW+KFA CREGED
Sbjct: 4 LFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGED 63
Query: 64 NSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSF 123
NSKRNPIAKI SD ++ QKITYRISGVGID+PP+G+F ++ TG+INIT++VDRE TP F
Sbjct: 64 NSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLF 123
Query: 124 LITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATD 183
LI CRALN++G D+E+PL L VK++DINDN PVFSQ ++ IEENS +N+LV+ L ATD
Sbjct: 124 LIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
Query: 184 ADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKD 243
ADE NHLNSKIA+KIVSQEP+G PMF+L+R TGEV T+++ LDREQ S Y LVV G+D+D
Sbjct: 184 ADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRD 243
Query: 244 G--EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNW 301
G +GLS++C+C IKV DVNDNFP + YSA IEEN LSSEL+R Q DLDEE TDNW
Sbjct: 244 GAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNW 303
Query: 302 LAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVIS 361
LA Y SGN+GNWF+IQTDP+TNEGILKVVK LDYEQ +++LSI VKN+A+FH SV S
Sbjct: 304 LAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVAS 363
Query: 362 RYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAAS 421
++++ TPV IQV++VREG AF P++ F+V++GI L++Y+LGTY AID DT A+
Sbjct: 364 QFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPAT 423
Query: 422 NVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTV 481
+V+Y++G + G +L IDS+T EI+F + ++ S +I+N TAE+LAID+ +GKT+TGT+
Sbjct: 424 DVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTI 483
Query: 482 YVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSI 541
+ VPD ND CP E+ +C SPSV++S + Y P+TF + D+P + +W +
Sbjct: 484 CIEVPDINDYCPNIFPERRTICIDSPSVLISVN--EHSYGSPFTFCVVDEPPGIADMWDV 541
Query: 542 TTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTS--- 598
+ NATSA+L A++ + PG Y I +++ DS N CE+ + + L C CD+ +C S
Sbjct: 542 RSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAA 601
Query: 599 --YPTTSPGTRYGRPHSGR-------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTG 649
Y G YG + LGPA IG+++LG+LLL+LAPLLLL C C
Sbjct: 602 GIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPE 661
Query: 650 GVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYAR 709
G+ F PVP+G EG + W IEGAHPED++++NIC P +N D M+SSE+ TNTYA
Sbjct: 662 GLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAA 721
Query: 710 GTAVE-GTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRT 768
G VE G SG+E+ T +G A V A+G ++G SG R
Sbjct: 722 GGTVEGGVSGVELNTGMGTA-------------VGLMAAG----------AAGASGAARK 758
Query: 769 RHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPV 828
R ST GT +DYAD I+M FLDSYFS+KA+A A+ED+G+ ANDCLLIYD+EG GSPV
Sbjct: 759 RSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEG---VGSPV 815
Query: 829 GSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQP-PSKDSGYGIESCGHP 887
GS+GCCS+I DDLD+S +++L PKF+ LAEI L E++P PS + I S P
Sbjct: 816 GSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNT-----EIEPFPSHQACIPI-STDLP 869
Query: 888 IEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPS 947
+ + FV ++ + + Q ++ +P+ HG+ +VTETY + VQP+
Sbjct: 870 L-LGPNYFV-------NESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPT 921
Query: 948 TAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTE 992
T FDP L NV+VTE V+ P+ + GN+ P +L + ++ E
Sbjct: 922 TIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAE 966
>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
Length = 1059
Score = 922 bits (2384), Expect = 0.0
Identities = 500/1024 (48%), Positives = 669/1024 (65%), Gaps = 77/1024 (7%)
Query: 4 LFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGED 63
LF R L I +VV+ V+ E +E K E T Q RRQKREW+KFA CREGED
Sbjct: 4 LFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGED 63
Query: 64 NSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSF 123
NSKRNPIAKI SD ++ QKITYRISGVGID+PP+G+F ++ TG+INIT++VDRE TP F
Sbjct: 64 NSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLF 123
Query: 124 LITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATD 183
LI CRALN++G D+E+PL L VK++DINDN PVFSQ ++ IEENS +N+LV+ L ATD
Sbjct: 124 LIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
Query: 184 ADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKD 243
ADE NHLNSKIA+KIVSQEP+G PMF+L+R TGEV T+++ LDREQ S Y LVV G+D+D
Sbjct: 184 ADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRD 243
Query: 244 G--EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNW 301
G +GLS++C+C IKV DVNDNFP + YSA IEEN LSSEL+R Q DLDEE TDNW
Sbjct: 244 GAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNW 303
Query: 302 LAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVIS 361
LA Y SGN+GNWF+IQTDP+TNEGILKVVK LDYEQ +++LSI VKN+A+FH SV S
Sbjct: 304 LAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVAS 363
Query: 362 RYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAAS 421
++++ TPV IQV++VREG AF P++ F+V++GI L++Y+LGTY AID DT A+
Sbjct: 364 QFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPAT 423
Query: 422 NVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTV 481
+V+Y++G + G +L IDS+T EI+F + ++ S +I+N TAE+LAID+ +GKT+TGT+
Sbjct: 424 DVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTI 483
Query: 482 YVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSI 541
+ VPD ND CP E+ +C SPSV++S + Y P+TF + D+P + +W +
Sbjct: 484 CIEVPDINDYCPNIFPERRTICIDSPSVLISVN--EHSYGSPFTFCVVDEPPGIADMWDV 541
Query: 542 TTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTS--- 598
+ NATSA+L A++ + PG Y I +++ DS N CE+ + + L C CD+ +C S
Sbjct: 542 RSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAA 601
Query: 599 --YPTTSPGTRYGRPHSGR-------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTG 649
Y G YG + LGPA IG+++LG+LLL+LAPLLLL C C
Sbjct: 602 GIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPE 661
Query: 650 GVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVP--PVTANGADFM---------- 697
G+ F PVP+G EG + W IEGAHPED+ + +P TA+G +
Sbjct: 662 GLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATP 721
Query: 698 -------ESSEVCTNTYARGTAVE-GTSGMEMTTKLGAATESGGAAGFATGTVSGAASGF 749
SE+ TNTYA G VE G SG+E+ T +G A V A+G
Sbjct: 722 ALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTA-------------VGLMAAG- 767
Query: 750 GAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEA 809
++G SG R R ST GT +DYAD I+M FLDSYFS+KA+A A+ED+G+ A
Sbjct: 768 ---------AAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPA 818
Query: 810 NDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKE 869
NDCLLIYD+EG GSPVGS+GCCS+I DDLD+S +++L PKF+ LAEI L E
Sbjct: 819 NDCLLIYDHEG---VGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNT-----E 870
Query: 870 VQP-PSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQH 928
++P PS + I S P+ + FV ++ + + Q ++ +P+ H
Sbjct: 871 IEPFPSHQACIPI-STDLPL-LGPNYFV-------NESSGLTPSEVEFQEEMAASEPVVH 921
Query: 929 GNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTM 988
G+ +VTETY + VQP+T FDP L NV+VTE V+ P+ + GN+ P +L + +
Sbjct: 922 GDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNV 981
Query: 989 LCTE 992
+ E
Sbjct: 982 IYAE 985
>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
Length = 1049
Score = 719 bits (1856), Expect = 0.0
Identities = 430/1003 (42%), Positives = 581/1003 (57%), Gaps = 126/1003 (12%)
Query: 5 FPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDN 64
F R L IF+VV+ V+ E RI+ + + + RRQKREW+KFA CREGEDN
Sbjct: 5 FFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDN 64
Query: 65 SKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFL 124
SKRNPIAKI SD A Q++TYRISGVGIDQPP+GIFV+++ TG+INIT+IVDRE TP F+
Sbjct: 65 SKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFI 124
Query: 125 ITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDA 184
I CRALN+ G D+E+PL L V++LDINDNPPVFS F G+IEENS +N+LVMILNATDA
Sbjct: 125 IYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDA 184
Query: 185 DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDG 244
DEPN+LNSKIAFKI+ QEP+ +PMF+++RNTGE+RT+ N LDREQ Y L V G+D+DG
Sbjct: 185 DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDG 244
Query: 245 --EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWL 302
+G+S +CECNIK+ DVNDN P S Y+ I+EN L+S LL +V DLDEE++ NW+
Sbjct: 245 GADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWM 304
Query: 303 AVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISR 362
AV FF SGNEGNWFEI+ + RTN GILKVVK LDYE +QS++LSI V+NKAEFH S++S+
Sbjct: 305 AVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQ 364
Query: 363 YRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASN 422
Y+++++ +++ V+NV EG FRP SKT+ V + S V G + A D DT + ++
Sbjct: 365 YKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKV----GDFVATDLDTGRPSTT 420
Query: 423 VKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVY 482
V+YVMG N L +DS+T ++ + ++ ++ +L+ID+ +T TGT+
Sbjct: 421 VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN 480
Query: 483 VRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSIT 542
+ + F ++ T ++ P+ ++ T
Sbjct: 481 INIQSFGNDDRT---------NTEPNTKITTNT--------------------------- 504
Query: 543 TLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTT 602
QE Y S TDS P + ++
Sbjct: 505 ---------GRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDL---------------L 540
Query: 603 SPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGS 662
S +G G L +G L+LGL+ P L++ CDCG GF PVP+ S
Sbjct: 541 SDNVHFGPAGIGLL---IMGFLVLGLV-----PFLMICCDCGGAPRS--AAGFEPVPECS 590
Query: 663 EGTIHQWGIEGAHPEDKEITNIC--VPPVTANGADFMESSEVCTNTYARGTAVEGTSGME 720
+G IH W +EG PE ++IT + +PP AN + +++S V TN Y G ++ G E
Sbjct: 591 DGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYG-GREMQDLGGGE 649
Query: 721 MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA 780
T TE +G IC SGT+R + ++
Sbjct: 650 RMTGF-ELTEGVKTSGMPE-----------------ICQE-YSGTLRR-----NSMRECR 685
Query: 781 DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD 840
+G ++MNF++SYF QKA+A A+ED+G+ +NDCLLIYD EG GSP GSVGCCSFI +D
Sbjct: 686 EGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEG---VGSPAGSVGCCSFIGED 742
Query: 841 LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQT-----GF 895
LDDSFLD+LGPKFKKLA+ISLG + P D + +S Q+T G
Sbjct: 743 LDDSFLDTLGPKFKKLADISLGKESY------PDLDPSWPPQSTEPVCLPQETEPVVSGH 796
Query: 896 VKCQTLSGSQGASALSTSGSVQPAVSIP----DPLQHGNYLVTETYSASGSLVQPSTAGF 951
G+ + ST S P V P DPL +GN VTE+Y+ S +L +PS
Sbjct: 797 PPISPHFGTTTVISESTYPS-GPGVLHPKPILDPLGYGNVTVTESYTTSDTL-KPSVHVH 854
Query: 952 DPLLTQNVIVTERVICPIS--SVPGNLAGPTQLRGSHTMLCTE 992
D NV+VTERV+ PIS + G L P LR ++ TE
Sbjct: 855 DNRPASNVVVTERVVGPISGADLHGMLEMP-DLRDGSNVIVTE 896
Score = 211 bits (538), Expect = 2e-54
Identities = 234/940 (24%), Positives = 386/940 (41%), Gaps = 158/940 (16%)
Query: 165 EIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNS 224
E E+NS N + I + A++ + +I+ + Q P G +F++++ TGE+ +T+
Sbjct: 60 EGEDNSKRNPIAKIHSDCAANQ--QVTYRISGVGIDQPPYG--IFVINQKTGEIN-ITSI 114
Query: 225 LDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSE 284
+DRE + + + G+ L E ++V D+NDN P+F + ++ +IEEN ++
Sbjct: 115 VDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANT 174
Query: 285 LLRF-QVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSV 343
L+ TD DE N + + + T E I + LD EQ
Sbjct: 175 LVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGE-IRTMNNFLDREQYGQY 233
Query: 344 KLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAF-RPASKTFTVQKGISSKKLV 402
L++ ++ + + I++++V + I + +S T +Q+ + L+
Sbjct: 234 ALAVRGSDRDGGADGMSAECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLL 288
Query: 403 DYILGTYQAIDEDTNKAAS--NVKYVMGRNDGGYLMID----SKTAEIKFVKNMNRDSTF 456
+ + ID D +A+ V + + N+G + I+ + +K VK ++ ++
Sbjct: 289 EI-----RVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
Query: 457 IVNKTITAEVLA------IDEYTGKTSTGTVYV----RVPDFNDNCPTAVLEKDAVCSSS 506
+ +I A + +Y K S +V V P F T V+ + +
Sbjct: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
Query: 507 PSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSIT-TLNATSALLRAQEQIPPGVYHIS 565
V+ R + + + + P L AV S T L + + + Q + G Y +
Sbjct: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
Query: 566 LVLTDSQNNR-CEMPRSLTLEVCQCDNR-----------------GICGTSYPTTSPGTR 607
++ D R C ++ ++ D+R T+Y T++ T
Sbjct: 464 ILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTD 523
Query: 608 YGRPHSGR--------------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTG 653
+ +S GPA IGLL++G L+L L P L++ CDCG
Sbjct: 524 SSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAA-- 581
Query: 654 GFIPVPDGSEGTIHQWGIEGAHPEDKEITNIC--VPPVTANGADFMESSEVCTNTYARGT 711
GF PVP+ S+G IH W +EG PE ++IT + +PP AN + +++S V TN Y G
Sbjct: 582 GFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYG-GR 640
Query: 712 AVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHS 771
++ G E T TE +G IC SGT+R
Sbjct: 641 EMQDLGGGERMTGF-ELTEGVKTSGMPE-----------------ICQE-YSGTLRRN-- 679
Query: 772 TGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSV 831
+ ++ +G ++MNF++SYF QKA+A A+ED+G+ +NDCLLIYD EG GSP GSV
Sbjct: 680 ---SMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGV---GSPAGSV 733
Query: 832 GCCSFIAD----------------------------DLDDSFLDS--------------- 848
GCCSFI + DLD S+
Sbjct: 734 GCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVV 793
Query: 849 -----LGPKFKKLAEISLGVDGEGKEVQPPSK---DSGYGIESCGHPIEVQQTGFVKCQT 900
+ P F IS G V P GYG + T
Sbjct: 794 SGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHV 853
Query: 901 LSGSQGASALSTSGSVQPA--------VSIPDPLQHGNYLVTETYSASGSLVQPSTAGFD 952
++ + T V P + +PD N +VTE A S + S
Sbjct: 854 HDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHH 913
Query: 953 PLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTE 992
P + NV+VTERVI P S + G+L+ +L +H ++ TE
Sbjct: 914 PRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTE 953
>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
Length = 1118
Score = 626 bits (1614), Expect = e-179
Identities = 386/1008 (38%), Positives = 577/1008 (57%), Gaps = 71/1008 (7%)
Query: 2 MGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKR-RQKREWVKFAKPCRE 60
M P AL + ++ V L ++ +E ++ + RQKR W+ RE
Sbjct: 1 MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALRE 60
Query: 61 GEDNSKRNPIAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDRE 118
GED SK+NPIAKI SD + KITY+ +G GI +PPFGIFV +K+TG++N+T+I+DRE
Sbjct: 61 GEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDRE 120
Query: 119 ETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMI 178
ETP FL+T AL+A+G +VEKPL L +K+LDINDN PVF+Q +F+G +EE SA+++LVM
Sbjct: 121 ETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMK 180
Query: 179 LNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVS 238
+NATDADEPN LNSKI+++IVS EPA P+F L+++TGE+ T + +LDRE+ SSY L V
Sbjct: 181 INATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVE 240
Query: 239 GADKDGEGLS---TQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDE 295
D +GE Q + I++ DVNDN P+ + +EEN ++ E+ R +V D DE
Sbjct: 241 ARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADE 300
Query: 296 EYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEF 355
+DNWLA + F SGNEG +F I+TD +TNEGI+ ++K +DYE+++++ S+ V NKA F
Sbjct: 301 IGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAF 360
Query: 356 HQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDED 415
H+S+ S+Y+ P+ ++V NV+EGI F+ + + V + + + I+G +QA DED
Sbjct: 361 HKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESM-DRSSKGQIIGNFQAFDED 419
Query: 416 TNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDE-YTG 474
T A + +YV + ++ +DS T+EIK K + +S ++ N T T +++AI E Y
Sbjct: 420 TGLPA-HARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPR 478
Query: 475 KTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNR-YTGPYTFALEDQPV 533
KT TGTV + V D NDNCPT + +C + V V+A L+ +GP++F++ D+P
Sbjct: 479 KTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPP 538
Query: 534 KLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRG 593
+ W I +TS LL+ E+ G I +++D+Q C + LTL VC+C +
Sbjct: 539 GMAEKWKIARQESTSVLLQQSEK-KLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGS 597
Query: 594 ICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTG 653
C + + G LGPAAI L++L LLLLL PLLLL C CG G+
Sbjct: 598 GCREAQHDSYVG----------LGPAAIALMILAFLLLLLVPLLLLMCHCGKGAK----- 642
Query: 654 GFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAV 713
GF P+P G+ +H W EGA PEDK + + PV G+ + A+ +
Sbjct: 643 GFTPIP-GTIEMLHPWNNEGAPPEDKVVPSFL--PVDQGGSLVGRNG---VGGMAKEATM 696
Query: 714 EGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTG 773
+G+S + +E G +SG A+ F ATG + + T +T +T
Sbjct: 697 KGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTE----TTKTARAT- 751
Query: 774 GTNKDYADG-----AISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPV 828
G ++D A A++ FL +YF+ KA + EED+ A DCLL+Y E ++ +
Sbjct: 752 GASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNA-- 809
Query: 829 GSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLG----VDGEGKEVQPPSKDSGYGIESC 884
S+GCCSFI +LDD FLD LG KFK LAE+ LG ++ E ++ Q P+ ++ + +
Sbjct: 810 -SIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATET--SMNTA 866
Query: 885 GHPIEVQQTGFVKCQTLSGS--------QGASA------------LSTSGSVQPAVSIPD 924
H + Q + SGS Q A+A +S+ + + A +PD
Sbjct: 867 SHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPD 926
Query: 925 PLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSV 972
P+ N + TET +GS + P+T P Q++IVTERV P S++
Sbjct: 927 PMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTL 974
Score = 34.7 bits (78), Expect = 0.46
Identities = 19/47 (40%), Positives = 29/47 (61%)
Query: 935 ETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQ 981
E++ A S VQP+ A + + QNV VTERV+ P S++ + PT+
Sbjct: 1020 ESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTE 1066
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 333 bits (853), Expect = 6e-91
Identities = 255/830 (30%), Positives = 392/830 (47%), Gaps = 68/830 (8%)
Query: 39 TMQQAKRRQKREWVKFAKPCREGEDNSKRNPI--AKITSDYQATQKITYRISGVGIDQPP 96
T ++ RR KR W PC E++ P+ ++ SD I Y I G G+DQ P
Sbjct: 125 TKEKVLRRAKRRWAPI--PCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEP 182
Query: 97 FGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPV 156
+F V+++TG++ T VDRE+ SF I A G E PL L +KI D NDN P+
Sbjct: 183 RNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPI 242
Query: 157 FSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTG 216
F+++ + I EN + V + ATD DEP+ +++++ + I+ Q P +F + TG
Sbjct: 243 FTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTG 302
Query: 217 EVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSA 274
+ T ++ LDRE Y+L + D DG+ GL T C I + DVND+ P F + Y
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362
Query: 275 RIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA 334
+EEN + E+LR V D D T NW A Y GNE F+I TD +TNEG+L VVK
Sbjct: 363 SVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKP 422
Query: 335 LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQK 394
L+YE+ Q + L I V N+A F + R + + VT+ V + EG P +T +++
Sbjct: 423 LNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKE 482
Query: 395 GISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS 454
V Y+A D +T +++S ++Y + G++ ID T IK ++++R++
Sbjct: 483 NAE----VGTTSNGYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREA 537
Query: 455 TFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVC--SSSPSVVVS 512
I N VLA D+ G+T TGT+ + + D NDN P + +C + S + +V+
Sbjct: 538 ETIKNGIYNITVLASDQ-GGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVA 596
Query: 513 ARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQ 572
+ P+ F+LE ++ +W + +N T+A L Q P G Y + + + D
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRD-- 654
Query: 573 NNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLL 632
R M +L+V CD C T T +LG AI +LLG+ LL
Sbjct: 655 --RLGMSSVTSLDVTLCD----CITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLF 708
Query: 633 LAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTAN 692
+L T CGA GT Q P+D N+ V A
Sbjct: 709 ---CILFTLVCGA-----------------SGTSKQ---PKVIPDDLAQQNLIVSNTEAP 745
Query: 693 GADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGF----ATGTVSGAASG 748
G D + S+ T T G + +G G +G+ ++GG S + G
Sbjct: 746 GDDKVYSANGFT-TQTVGASAQGVCG-----TVGSGIKNGGQETIEMVKGGHQTSESCRG 799
Query: 749 FGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQE 808
G + C G + R++ Y++ +F +K + C ++++ +
Sbjct: 800 AGHHHTLDSCRGGHTEVDNCRYT-------YSEW---HSFTQPRLGEKVYLCNQDENHKH 849
Query: 809 ANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAE 858
A D +L Y+ EG GS GSVGCCS ++ FLD+L PKF+ LAE
Sbjct: 850 AQDYVLTYNYEG---RGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAE 896
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 317 bits (811), Expect = 5e-86
Identities = 245/846 (28%), Positives = 396/846 (46%), Gaps = 81/846 (9%)
Query: 27 IETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPI--AKITSDYQATQKIT 84
+E + + + T + RR KR W PC E++ P+ ++ SD +
Sbjct: 113 LEHQKKVSKTRHTRETVLRRAKRRWAPI--PCSMQENSLGPFPLFLQQVESDAAQNYTVF 170
Query: 85 YRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILT 144
Y ISG G+D+ P +F ++++TG++ T VDREE F + A A G + PL L
Sbjct: 171 YSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP 230
Query: 145 VKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPA 204
+++ D NDN PVF++ I+ E+ E+S + V ++ ATD DEP+ +++++ + I+ Q P
Sbjct: 231 IRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR 290
Query: 205 GTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVND 262
+F + +TG + T+++ LDRE Y L++ D DG+ GL C I V D ND
Sbjct: 291 SPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSND 350
Query: 263 NFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDP 322
N P FR + Y A +EEN + E+LR + D D T NW + GNE F+I TD
Sbjct: 351 NAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDK 410
Query: 323 RTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIA 382
TNEG+L VVK L+YE+ + V L I V N+A F + + + VT+ V ++ EG
Sbjct: 411 ETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPE 470
Query: 383 FRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTA 442
PA++ +++ ++ V + Y+A D + N+ + ++Y + G++ ID +
Sbjct: 471 CTPAAQYVRIKENLA----VGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISG 525
Query: 443 EIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAV 502
I K ++R+ N+ VLAID+ ++ TGT+ V + D NDN P + E +
Sbjct: 526 SIITSKILDREVETPKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVI 584
Query: 503 CSSSPSV--VVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPG 560
C +++ + P+ F+L + ++ +WS+T +N T+A L Q+
Sbjct: 585 CKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
Query: 561 VYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAA 620
Y I + + D + L + +C+C ++PT T R LG A
Sbjct: 645 EYTIPITVKDRAGQAA--TKLLRVNLCEC--------THPTQCRAT--SRSTGVILGKWA 692
Query: 621 IGLLLLGLLLLLLAPLLLLTCDCGA-GSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDK 679
I +LLG+ LL +LLT CG G+T G PED
Sbjct: 693 ILAILLGIALLF---SVLLTLVCGVFGATKG----------------------KRFPEDL 727
Query: 680 EITNICVPPVTANGADFMESSEVCT-NTYARGTAVEGTSGMEMTTKLGAATESGGAAGFA 738
N+ + A G D VC+ N + T + G T +G+ ++GG
Sbjct: 728 AQQNLIISNTEAPGDD-----RVCSANGFMTQTTNNSSQGFCGT--MGSGMKNGGQE--T 778
Query: 739 TGTVSGAASGFGAATGVG------ICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSY 792
+ G + G G C G + R++ Y++ +F
Sbjct: 779 IEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYT-------YSEW---HSFTQPR 828
Query: 793 FSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPK 852
+K C + +D + D +L Y+ EG GSP GSVGCCS ++ FL++L PK
Sbjct: 829 LGEKLHRCNQNEDRMPSQDYVLTYNYEG---RGSPAGSVGCCSEKQEEDGLDFLNNLEPK 885
Query: 853 FKKLAE 858
F LAE
Sbjct: 886 FITLAE 891
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 312 bits (800), Expect = 9e-85
Identities = 245/824 (29%), Positives = 386/824 (46%), Gaps = 62/824 (7%)
Query: 39 TMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFG 98
T A +R KR W E + +I SD I Y ISG G+D+ PF
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
Query: 99 IFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFS 158
+F ++K+TGDI T +DRE+ F + A A G E PL L +KI D NDN P F
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
Query: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEV 218
++ + + EN S + V + ATD DEP+ L++++ +KI+ Q P F + +TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
Query: 219 RTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI 276
T T LDRE+ +Y+L++ D G+ GL I ++D NDN P F ++ Y +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
Query: 277 EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALD 336
EEN + E+LR +V D D T + AVY GNE F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
Query: 337 YEQLQSVKLSIAVKNKAEFHQSVISRYRVQ-STPVTIQVINVREGIAFRPASKTFTVQKG 395
YE + V L + V N+A+F ++ S+ +T VT+++I+ EG P K Q G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
Query: 396 ISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDST 455
+ + +LG Y+A+D + + + ++Y ++ + I+ T +++ +K ++R+S
Sbjct: 484 FPAGQ---ELLG-YKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESK 538
Query: 456 FIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSART 515
F+ N V+A+D G++ TGT+ V + D+ND+ P E ++ V+
Sbjct: 539 FVKNNQYNISVVAVDA-VGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVD 597
Query: 516 LNNRYTG-PYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNN 574
+ G P+ F L++ K W+I + +A+LR ++ + Y + + + D +
Sbjct: 598 PDGPENGPPFQFFLDNSASK---NWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RH 652
Query: 575 RCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLA 634
LT+ VC C C TR RP+ LG AI ++LG +LLL
Sbjct: 653 GLVATHMLTVRVCDCSTPSECRMK----DKSTRDVRPNV-ILGRWAILAMVLGSVLLL-- 705
Query: 635 PLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGA 694
+L TC C T T D ++ + EG E E NI +P
Sbjct: 706 -CILFTCFC---VTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTE-ANIRLP------- 753
Query: 695 DFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATG 754
M++S +C + + GT G + T+ G G + G G T
Sbjct: 754 --MQTSNICDTSMSVGT----VGGQGIKTQQSFEMVKG-------GYTLDSNKGGGHQTL 800
Query: 755 VGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLL 814
+ GQ T R ++ +F +K + C ++++ + D +
Sbjct: 801 ESVKGVGQGDTGRYAYTDW------------QSFTQPRLGEKVYLCGQDEEHKHCEDYVC 848
Query: 815 IYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAE 858
Y+ EG GS GSVGCCS ++ FLD L PKF+ LA+
Sbjct: 849 SYNYEG---KGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAK 889
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 298 bits (764), Expect = 1e-80
Identities = 189/607 (31%), Positives = 308/607 (50%), Gaps = 30/607 (4%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDK 104
+RQKR+WV E + +I SD + Y ++G G DQPP GIF+++
Sbjct: 155 QRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINP 214
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMG 164
+G +++T +DRE+ F + A++ G VE P+ + + ++D+NDN P F Q++ G
Sbjct: 215 ISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNG 274
Query: 165 EIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTP---MFLLSRNTGEVRTL 221
+ E S + VM + A DAD+PN LN + ++IVSQ P+ TP MF ++ TG++ T+
Sbjct: 275 TVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPS-TPSPNMFTINNETGDIITV 333
Query: 222 TNSLDREQASSYRLVVSGADKDGE---GLSTQCECNIKVKDVNDNFPMFRDSQYSARIEE 278
LDRE+ Y L++ D +G GLS I V DVNDN P F + + E
Sbjct: 334 AAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPE 393
Query: 279 NILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYE 338
N + + VTD D+ +T W AVY + G+ F IQTDP +N+G++ VVK +D+E
Sbjct: 394 NRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFE 453
Query: 339 QLQSVKLSIAVKNKAEFHQSVISRYRVQST-PVTIQVINVREGIAFRPASKTFTVQKGIS 397
+ L++A +N+ + + ++ QST V++ VI+V E F P K ++G+
Sbjct: 454 TNRMFVLTVAAENQVPLAKGI--QHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLH 511
Query: 398 SKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFI 457
+ + L T+ A D D N++Y + +L ID +I + ++R+S +
Sbjct: 512 AGTM----LTTFTAQDPD-RYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNV 566
Query: 458 VNKTITAEVLAIDE-YTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTL 516
N A LA D + TGT+ + + D NDN P + ++ C + ++ L
Sbjct: 567 KNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITAL 626
Query: 517 N---NRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQ-EQIPPGVYHISLVLTDSQ 572
+ + GP+ F L PV + W+IT LN A L + + + G+Y + +++TDS
Sbjct: 627 DYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSG 686
Query: 573 NNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLL 632
N L ++VCQCD+ G C T R LG AI +LL +++LL
Sbjct: 687 NPPKSNISILRVKVCQCDSNGDC----------TDVDRIVGAGLGTGAIIAILLCIIILL 736
Query: 633 LAPLLLL 639
+ L+ +
Sbjct: 737 ILVLMFV 743
Score = 40.8 bits (94), Expect = 0.006
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 793 FSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPK 852
F + A+ D D LL++D EG+ +T + S+ S + D +L+ GP+
Sbjct: 835 FINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSS-SGGEQDYDYLNDWGPR 893
Query: 853 FKKLAEISLGVD 864
FKKLA++ G D
Sbjct: 894 FKKLADMYGGGD 905
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 295 bits (756), Expect = 1e-79
Identities = 220/701 (31%), Positives = 336/701 (47%), Gaps = 51/701 (7%)
Query: 39 TMQQAKRRQKREWVKFAKPCREGEDNSKRNPI--AKITSDYQATQKITYRISGVGIDQPP 96
T ++ RR KR W PC E++ P+ ++ SD I Y I G G+DQ P
Sbjct: 125 TKEKVLRRAKRRWAPI--PCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEP 182
Query: 97 FGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPV 156
+F V+++TG++ T VDRE+ SF I A G E PL L +KI D NDN P+
Sbjct: 183 RNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPI 242
Query: 157 FSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTG 216
F+++ + I EN + V + ATD DEP+ +++++ + I+ Q P +F + TG
Sbjct: 243 FTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTG 302
Query: 217 EVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSA 274
+ T ++ LDRE Y+L + D DG+ GL T C I + DVND+ P F + Y
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362
Query: 275 RIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA 334
+EEN + E+LR V D D T NW A Y GNE F+I TD +TNEG+L VVK
Sbjct: 363 SVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKP 422
Query: 335 LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQK 394
L+YE+ Q + L I V N+A F + R + + VT+ V + EG P +T +++
Sbjct: 423 LNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKE 482
Query: 395 GISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS 454
V Y+A D +T +++S ++Y + G++ ID T IK ++++R++
Sbjct: 483 NAE----VGTTSNGYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREA 537
Query: 455 TFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVC--SSSPSVVVS 512
I N VLA D+ G+T TGT+ + + D NDN P + +C + S + +V+
Sbjct: 538 ETIKNGIYNITVLASDQ-GGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVA 596
Query: 513 ARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQ 572
+ P+ F+LE ++ +W + +N T+A L Q P G Y + + + D
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRD-- 654
Query: 573 NNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLL 632
R M +L+V CD C T T +LG AI +LLG+ LL
Sbjct: 655 --RLGMSSVTSLDVTLCD----CITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLF 708
Query: 633 LAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTAN 692
+L T CGA GT Q P+D N+ V A
Sbjct: 709 ---CILFTLVCGA-----------------SGTSKQ---PKVIPDDLAQQNLIVSNTEAP 745
Query: 693 GADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGG 733
G D + S+ T T G + +G G +G+ ++GG
Sbjct: 746 GDDKVYSANGFT-TQTVGASAQGVCG-----TVGSGIKNGG 780
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 291 bits (744), Expect = 3e-78
Identities = 188/606 (31%), Positives = 303/606 (50%), Gaps = 28/606 (4%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDK 104
RR+KR+WV E + +I SD I Y I+GVG DQPP +F +D
Sbjct: 165 RRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDS 224
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMG 164
+G + +T +DREE S+ + A++ G VE P+ L + ++D+NDN P F Q++ G
Sbjct: 225 MSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNG 284
Query: 165 EIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTP--MFLLSRNTGEVRTLT 222
++E S + VM + A DAD+ N + ++IV+Q P MF ++ TG++ T+
Sbjct: 285 SVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVA 344
Query: 223 NSLDREQASSYRLVVSGADKDGE---GLSTQCECNIKVKDVNDNFPMFRDSQYSARIEEN 279
LDRE+ Y ++V D +G GLS I V DVNDN P F S ++ + EN
Sbjct: 345 AGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPEN 404
Query: 280 ILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQ 339
+ + + V D D+ ++ NW AVY SG+ F ++TDP TNEG++ VVKA+DYE
Sbjct: 405 RVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYEL 464
Query: 340 LQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK 399
++ L++ V N+A + ++ + VTI ++++ E F K +++G+
Sbjct: 465 NRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISIMDINEAPYFPSNHKLIRLEEGVPP- 522
Query: 400 KLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVN 459
+L T+ A+D D + V+Y + +L I++ +I ++R+S + N
Sbjct: 523 ---GTVLTTFSAVDPDRFMQQA-VRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKN 578
Query: 460 KTITAEVLAIDEYTGKTS-TGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSV----VVSAR 514
A LA D S TGT+ + + D NDN P +L K+A P++ + +A
Sbjct: 579 NVYEATFLAADNGIPPASGTGTLQIYLIDINDNAP-ELLPKEAQICEKPNLNAINITAAD 637
Query: 515 TLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQ-EQIPPGVYHISLVLTDSQN 573
+ GPY F L P + W+IT LN A L + + G+Y + +++TDS N
Sbjct: 638 ADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGN 697
Query: 574 NRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLL 633
+ ++VC CD+ G C T G + LG AI +L+ +L+LL
Sbjct: 698 PPLSNTSIIKVKVCPCDDNGDC----------TTIGAVAAAGLGTGAIVAILICILILLT 747
Query: 634 APLLLL 639
LL +
Sbjct: 748 MVLLFV 753
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 793 FSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPK 852
F + A+ D D LL++D EG+ +T V S+ S + D D +L+ GP+
Sbjct: 845 FINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSS--SGDQDYDYLNDWGPR 902
Query: 853 FKKLAEI 859
FKKLA++
Sbjct: 903 FKKLADM 909
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 287 bits (735), Expect = 3e-77
Identities = 207/650 (31%), Positives = 318/650 (48%), Gaps = 47/650 (7%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDK 104
RRQKR+WV C E E + +I S+ K+ Y I+G G D PP G+F++++
Sbjct: 150 RRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIER 209
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMG 164
TG + +T +DRE ++ + A+++ G VE P+ + + + D NDN P F+Q++F G
Sbjct: 210 ETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKG 269
Query: 165 EIEENSASNSLVMILNATDADEP-NHLNSKIAFKIVSQEP--AGTPMFLLSRNTGEVRTL 221
+ E + + VM + ATDAD+ N N+ IA+ I+SQ+P MF ++RNTG + +
Sbjct: 270 SVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVV 329
Query: 222 TNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENIL 281
T LDRE +Y LVV AD GEGLST I V D NDN P+F + Y ++ EN
Sbjct: 330 TTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEA 389
Query: 282 SSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQ 341
+ + +VTD D T W AVY + ++G F + T+P N+GILK K LD+E Q
Sbjct: 390 NVVITTLKVTDADAPNTPAWEAVYTILN-DDGGQFVVTTNPVNNDGILKTAKGLDFEAKQ 448
Query: 342 SVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKL 401
L +AV N F S+ + + VT+ V++V E F P K V +
Sbjct: 449 QYILHVAVTNVVPFEVSLTT----STATVTVDVLDVNEAPIFVPPEKRVEVSEDFG---- 500
Query: 402 VDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNR-DSTFIVNK 460
V + +Y A + DT + Y + R+ +L I+ T I ++R D + N
Sbjct: 501 VGQEITSYTAQEPDT-FMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNS 559
Query: 461 TITAEVLAIDEYTG-KTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSV----VVSART 515
T TA ++A D + T TGT+ + + D NDN P C +P ++ A
Sbjct: 560 TYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADL 619
Query: 516 LNNRYTGPYTFALEDQPVKLPAVWSITTLNAT--SALLRAQEQIPPGVYHISLVLTDSQN 573
N T P+T L A W+I + T S +L+ + + G Y I+L L D+QN
Sbjct: 620 PPN--TSPFTAELTH---GASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQN 674
Query: 574 NRCEMPRSLTLEVCQCDN-RGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLL--LLGLLL 630
+ +L + VC C+ G+C + P +G PA +G+L +L LL+
Sbjct: 675 K--DQVTTLEVSVCDCEGAAGVCRKAQPV----------EAGLQIPAILGILGGILALLI 722
Query: 631 LLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKE 680
L+L LL L V +P D + ++ + EG ED++
Sbjct: 723 LILLLLLFLR------RRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQD 766
Score = 33.1 bits (74), Expect = 1.3
Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 793 FSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPK 852
F + A+ D D LL++D EG+ + + + S+ S D D +L+ G +
Sbjct: 810 FIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNS-SESDKDQDYDYLNEWGNR 868
Query: 853 FKKLAEI 859
FKKLA++
Sbjct: 869 FKKLADM 875
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 285 bits (730), Expect = 1e-76
Identities = 214/743 (28%), Positives = 346/743 (46%), Gaps = 86/743 (11%)
Query: 27 IETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPI--AKITSDYQATQKIT 84
+E + + + T + RR KR W PC E++ P+ ++ SD +
Sbjct: 113 LEHQKKVSKTRHTRETVLRRAKRRWAPI--PCSMQENSLGPFPLFLQQVESDAAQNYTVF 170
Query: 85 YRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILT 144
Y ISG G+D+ P +F ++++TG++ T VDREE F + A A G + PL L
Sbjct: 171 YSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP 230
Query: 145 VKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPA 204
+++ D NDN PVF++ I+ E+ E+S + V ++ ATD DEP+ +++++ + I+ Q P
Sbjct: 231 IRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR 290
Query: 205 GTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVND 262
+F + +TG + T+++ LDRE Y L++ D DG+ GL C I V D ND
Sbjct: 291 SPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSND 350
Query: 263 NFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDP 322
N P FR + Y A +EEN + E+LR + D D T NW + GNE F+I TD
Sbjct: 351 NAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDK 410
Query: 323 RTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIA 382
TNEG+L VVK L+YE+ + V L I V N+A F + + + VT+ V ++ EG
Sbjct: 411 ETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPE 470
Query: 383 FRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTA 442
PA++ +++ ++ V + Y+A D + N+ + ++Y + G++ ID +
Sbjct: 471 CTPAAQYVRIKENLA----VGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISG 525
Query: 443 EIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAV 502
I K ++R+ N+ VLAID+ ++ TGT+ V + D NDN P + E +
Sbjct: 526 SIITSKILDREVETPKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVI 584
Query: 503 CSSSPSV--VVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPG 560
C +++ + P+ F+L + ++ +WS+T +N T+A L Q+
Sbjct: 585 CKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
Query: 561 VYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAA 620
Y I + + D + L + +C+C ++PT T R LG A
Sbjct: 645 EYTIPITVKDRAGQAA--TKLLRVNLCEC--------THPTQCRAT--SRSTGVILGKWA 692
Query: 621 IGLLLLGLLLLLLAPLLLLTCDCGA-GSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDK 679
I +LLG+ LL +LLT CG G+T G PED
Sbjct: 693 ILAILLGIALLF---SVLLTLVCGVFGATKG----------------------KRFPEDL 727
Query: 680 EITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFAT 739
N+ + A G D VC+ A GF T
Sbjct: 728 AQQNLIISNTEAPGDD-----RVCS-----------------------------ANGFMT 753
Query: 740 GTVSGAASGFGAATGVGICSSGQ 762
T + ++ GF G G+ + GQ
Sbjct: 754 QTTNNSSQGFCGTMGSGMKNGGQ 776
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 281 bits (720), Expect = 2e-75
Identities = 219/719 (30%), Positives = 344/719 (47%), Gaps = 42/719 (5%)
Query: 39 TMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFG 98
T A +R KR W E + +I SD I Y ISG G+D+ PF
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
Query: 99 IFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFS 158
+F ++K+TGDI T +DRE+ F + A A G E PL L +KI D NDN P F
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
Query: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEV 218
++ + + EN S + V + ATD DEP+ L++++ +KI+ Q P F + +TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
Query: 219 RTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI 276
T T LDRE+ +Y+L++ D G+ GL I ++D NDN P F ++ Y +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
Query: 277 EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALD 336
EEN + E+LR +V D D T + AVY GNE F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
Query: 337 YEQLQSVKLSIAVKNKAEFHQSVISRYRVQ-STPVTIQVINVREGIAFRPASKTFTVQKG 395
YE + V L + V N+A+F ++ S+ +T VT+++I+ EG P K Q G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
Query: 396 ISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDST 455
+ + +LG Y+A+D + + + ++Y ++ + I+ T +++ +K ++R+S
Sbjct: 484 FPAGQ---ELLG-YKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESK 538
Query: 456 FIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSART 515
F+ N V+A+D G++ TGT+ V + D+ND+ P E ++ V+
Sbjct: 539 FVKNNQYNISVVAVDA-VGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVD 597
Query: 516 LNNRYTG-PYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNN 574
+ G P+ F L++ K W+I + +A+LR ++ + Y + + + D +
Sbjct: 598 PDGPENGPPFQFFLDNSASK---NWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RH 652
Query: 575 RCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLA 634
LT+ VC C C TR RP+ LG AI ++LG +LLL
Sbjct: 653 GLVATHMLTVRVCDCSTPSECRMK----DKSTRDVRPNV-ILGRWAILAMVLGSVLLL-- 705
Query: 635 PLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGA 694
+L TC C T T D ++ + EG E E NI +P
Sbjct: 706 -CILFTCFC---VTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTE-ANIRLP------- 753
Query: 695 DFMESSEVCTNTYARGT----AVEGTSGMEMTTKLGAATESGGAAGFAT-GTVSGAASG 748
M++S +C + + GT ++ EM K G +S G T +V G G
Sbjct: 754 --MQTSNICDTSMSVGTVGGQGIKTQQSFEM-VKGGYTLDSNKGGGHQTLESVKGVGQG 809
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 276 bits (707), Expect = 5e-74
Identities = 188/606 (31%), Positives = 306/606 (50%), Gaps = 35/606 (5%)
Query: 43 AKRRQKREWVKFAKPCREGEDNSKR--NPIAKITSDYQATQKITYRISGVGIDQPPFGIF 100
A R +R WV P +N KR P+ +I SD Q + Y I G G+D+ P G+F
Sbjct: 39 ALSRVRRAWVI---PPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVF 95
Query: 101 VVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQ 160
+DK TG + + A++DRE+T F + AL+ G +E P L + ++D NDN P F Q+
Sbjct: 96 SIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQE 155
Query: 161 IFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTP-MFLLSRNTGEVR 219
F G + E + + V ATDAD+P N+ + F I+ Q G+P +F + TGE+R
Sbjct: 156 AFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ---GSPELFSIDELTGEIR 212
Query: 220 TLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEEN 279
T+ LDRE + Y L + AD G+GL+ I + D+NDN P F ++ E
Sbjct: 213 TVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEA 272
Query: 280 ILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQ 339
+ ++ R +V D D + NW+A + G+ F I+TDP+TNEG+L +VKALDYE
Sbjct: 273 VSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYES 332
Query: 340 LQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK 399
+ +L ++V+N+A + + R Q+ V + V + E F+ ++ +G
Sbjct: 333 CEHYELKVSVQNEAPLQAAALRAERGQA-KVRVHVQDTNEPPVFQENPLRTSLAEGAPPG 391
Query: 400 KLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVN 459
LV T+ A D DT + + Y + +L +D+ T I+ ++ S F+
Sbjct: 392 TLV----ATFSARDPDTEQ-LQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKG 446
Query: 460 KTITAEVLAIDEYT-GKTSTGTVYVRVPDFNDNCPT-AVLEKDAVCS---SSPSVVVSAR 514
A VLA D+ + +T+TGT+ + + + ND+ P A ++CS P +++ A
Sbjct: 447 GWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGAT 506
Query: 515 TLN-NRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQN 573
+ + P+ F L + +L WS++ +N + A LR + Q+P G++ +SL+L DS
Sbjct: 507 DEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQ 566
Query: 574 NRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLL 633
+ + L + VC+C G+C P + L GL L L+++L
Sbjct: 567 PPQQREQPLNVTVCRCGKDGVC--------------LPGAAALLAGGTGLSLGALVIVLA 612
Query: 634 APLLLL 639
+ LLLL
Sbjct: 613 SALLLL 618
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 261 bits (666), Expect = 3e-69
Identities = 188/643 (29%), Positives = 301/643 (46%), Gaps = 40/643 (6%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDK 104
RR KR+WV E + ++ S+ KI Y I+G G D PP G+F V+K
Sbjct: 103 RRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEK 162
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMG 164
TG + + +DREE + + A++ G VE P+ +++ + D ND+ P F+Q F G
Sbjct: 163 ETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRG 222
Query: 165 EIEENSASNSLVMILNATDADEPNHL-NSKIAFKIVSQEPAGTP--MFLLSRNTGEVRTL 221
+ E + VM + ATD D+ + N +A+ I SQEP MF + R+TG + +
Sbjct: 223 SVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVI 282
Query: 222 TNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENIL 281
++ LDRE+ Y L + D DG+G +T +++ D NDN PMF +Y A + EN +
Sbjct: 283 SSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAV 342
Query: 282 SSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQ 341
E+ R VTDLD + W A Y G++G+ F I T P +N+GIL K LD+E
Sbjct: 343 GHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKN 402
Query: 342 SVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKL 401
L + V N+A F + + + + + V +V E F P SK VQ+GI + +
Sbjct: 403 QHTLYVEVTNEAPF----VLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEP 458
Query: 402 VDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNR-DSTFIVNK 460
V Y A ED +K + Y + R+ G+L +D + ++ V ++R D F+ N
Sbjct: 459 V----CVYTA--EDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNN 512
Query: 461 TITAEVLAIDEYTGKTS-TGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNR 519
VLA+D + T+ TGT+ + + D ND+ P + +C+ SP V + ++
Sbjct: 513 IYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSP--VRQVLNITDK 570
Query: 520 YTGPYTFALEDQPVKLPAVWSITTLN--ATSALLRAQEQIPPGVYHISLVLTDSQNNRCE 577
P+T + Q ++ +N + +L ++ + Y + L L+D N E
Sbjct: 571 DLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNK--E 628
Query: 578 MPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLL 637
+ VC C + T PG P G +G +L LL LLL LL
Sbjct: 629 QLTVIRATVCDCH-------GHVETCPG-----PWKGGFILPVLG-AVLALLFLLLVLLL 675
Query: 638 LLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKE 680
L+ + + D + + +G EG ED++
Sbjct: 676 LVR------KKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQD 712
Score = 32.3 bits (72), Expect = 2.3
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 801 AEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEI 859
A D D LL++D EG+ + + + S+ S D D +L+ G +FKKLA++
Sbjct: 765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSL-TSSASDQDQDYDYLNEWGSRFKKLADM 822
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 237 bits (605), Expect = 4e-62
Identities = 173/560 (30%), Positives = 273/560 (48%), Gaps = 24/560 (4%)
Query: 46 RQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKN 105
RQKR V E + + K+ D ++ +R++G G+DQ P GIF +++N
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKVV-DSDRPERSKFRLTGKGVDQEPKGIFRINEN 193
Query: 106 TGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGE 165
TG +++T +DRE + + + G +E P+ L V ++D NDN P+F + ++G
Sbjct: 194 TGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGH 253
Query: 166 IEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEP--AGTPMFLLSRNTGEVRTLTN 223
+ E S + + VM + A DAD+P N+ + + I Q P MF + G++ T+ +
Sbjct: 254 VMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVS 313
Query: 224 S--LDRE--QASSYRLVVSGADKDG--EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIE 277
LDRE + Y L++ D G GL+ I + D ND+ P F ++ A +E
Sbjct: 314 PALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVE 373
Query: 278 ENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDY 337
E + ++ V D D+ T W A Y +GN G FEI T+P+TNEG+L VVK LDY
Sbjct: 374 EGAV-GVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDY 432
Query: 338 EQLQSVKLSIAVKNKAEFHQSVISRYRVQST-PVTIQVINVREGIAFRPASKTFTVQKGI 396
E L I V+N+ V Y ST V I V++V EG F P T Q+ +
Sbjct: 433 EISAFHTLLIKVENEDPLVPDV--SYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDL 490
Query: 397 SSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTF 456
S V +L T A D D+ + ++Y + ++ G+L I+ + ++R+S F
Sbjct: 491 S----VGSVLLTVNATDPDSLQ-HQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPF 545
Query: 457 IVNKTITAEVLAIDE-YTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSP--SVVVSA 513
+ N TA LAID T TGT+ + + D NDN P VC + SVV+
Sbjct: 546 VDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILG 605
Query: 514 RTLNNRY--TGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDS 571
+ + + T P+ F + Q V VW I+ +N T AL+ + + Y++ +++TDS
Sbjct: 606 ASDKDLHPNTDPFKFEIHKQAVP-DKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDS 664
Query: 572 QNNRCEMPRSLTLEVCQCDN 591
L ++VC C N
Sbjct: 665 GKPPMTNITDLRVQVCSCRN 684
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 229 bits (584), Expect = 1e-59
Identities = 179/644 (27%), Positives = 298/644 (46%), Gaps = 39/644 (6%)
Query: 11 ALAIFVVVILVHGELRIETKGQYDEEEMTMQ------QAKRRQKREWVKFAKPCREGEDN 64
+L + +V++L ++ I Q + +++T Q Q RR KR WV E +
Sbjct: 10 SLLLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPG 69
Query: 65 SKRNPIAKITSDYQATQKITYRISGVGIDQ-PPFGIFVV-DKNTGDINITAIVDREETPS 122
I ++ ++ + Y ISG G+D+ P G+F + D G I + VDRE TPS
Sbjct: 70 PFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPS 129
Query: 123 FLITCRALN-AQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNA 181
F + + + G V+ LI ++I D+ND+ P F ++ F ++EN ++ + + A
Sbjct: 130 FTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLA 189
Query: 182 TDADEPNHLNSKIAFKIVSQEPAGTPM-FLLSRNTGEVRTLTNSLDREQASSYRLVVSGA 240
D DE N NS++ + ++SQ P F + R +GE+R L+ LD E A + L++
Sbjct: 190 VDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIR-LSGCLDYETAPQFTLLIRAR 248
Query: 241 DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN 300
D LS+ ++ V++ N++ P F Y +I E S +LR V D D +T
Sbjct: 249 DCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSA 308
Query: 301 WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNK-----AEF 355
W A + GNE F+I TDP TNEGIL V+K LDYE + L I V+N+ E
Sbjct: 309 WRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCER 368
Query: 356 HQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDED 415
+ R S V++QV + + AF P S ++G L LGT+ A+D D
Sbjct: 369 GKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTL----LGTFNAMDPD 424
Query: 416 TNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDE-YTG 474
S ++Y + + ++ +D + + V+ ++R+S + N + A+D+ +
Sbjct: 425 -----SQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPP 479
Query: 475 KTSTGTVYVRVPDFNDNCPTAVLEKD--AVCSSS---PSVVVSARTLNNRYTGPYTFALE 529
+T+TGT+ + + D NDN PT VC S+ P + + ++ P+TF L+
Sbjct: 480 QTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELD 539
Query: 530 DQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQC 589
+ W + S L +P G Y + L + D Q +++ + +C C
Sbjct: 540 NTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQG--LSQKQTVHVRICPC 597
Query: 590 DNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLL 633
+ G+ G H G L P + L + LL L
Sbjct: 598 AS-GLTCVELADAEVGL-----HVGALFPVCAAFVALAVALLFL 635
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 186 bits (472), Expect = 9e-47
Identities = 180/626 (28%), Positives = 279/626 (44%), Gaps = 61/626 (9%)
Query: 41 QQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGI 99
Q + R KR WV E S + K+ SD + I Y +SG G I
Sbjct: 39 QSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----I 94
Query: 100 FVVDKNTGDINITAIVDREETPSFLITCRALNA-QGLDVEKPLILTVKILDINDNPPVFS 158
F++D+NTGDI+ T +DREE + + +AL+ VE +KI DINDN P F
Sbjct: 95 FIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFL 154
Query: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGE 217
+ + E S + V+ + ATDAD+P + NS ++ + I+ G P F + TG
Sbjct: 155 DGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQ----GQPYFSVEPKTGV 210
Query: 218 VRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSAR 275
++T ++DRE Y LV+ D G+ GLS + + DVNDN P F Y
Sbjct: 211 IKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYN 270
Query: 276 IEENI-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA 334
+ E++ ++S + R + D D N Y G+ F+I D T EGI+ + K
Sbjct: 271 VPESLPVASVVARIKAADAD--IGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKE 328
Query: 335 LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQK 394
LD+E S L I NK + + +T V I V +V E F +S + ++
Sbjct: 329 LDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVF--SSPLYPME- 385
Query: 395 GISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDG--GYLMIDSKTAEIKFVKNMNR 452
+S V I+GT A D D++ S V+Y + RN Y ID+ + I K+++R
Sbjct: 386 -VSEATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDR 442
Query: 453 DSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLE-KDAVC-SSSPSVV 510
++ I N T+ A G+ G V + + D NDN P ++ + VC ++ P V
Sbjct: 443 ETNAIHNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQV 499
Query: 511 VSA----------------RTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQ 554
+ +L T + F+L+D ++ +T N R Q
Sbjct: 500 IQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASI--LTRRNG----FRRQ 553
Query: 555 EQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSG 614
EQ VY++ + + DS + +LT+ VC CD G+ T Y P
Sbjct: 554 EQ---SVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVA-----QTCNAEAYVLP--A 603
Query: 615 RLGPAAIGLLLLGLLLLLLAPLLLLT 640
L A+ +L +L LL+ LL++T
Sbjct: 604 GLSTGALIAILACVLTLLVLILLIVT 629
Score = 30.4 bits (67), Expect = 8.7
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 801 AEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEI 859
A+ D G D L Y EG + + S+ S +D D +L GP+FK+LA++
Sbjct: 718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYD-YLSDWGPRFKRLADM 775
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 186 bits (472), Expect = 9e-47
Identities = 180/626 (28%), Positives = 279/626 (44%), Gaps = 61/626 (9%)
Query: 41 QQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGI 99
Q + R KR WV E S + K+ SD + I Y +SG G I
Sbjct: 39 QSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----I 94
Query: 100 FVVDKNTGDINITAIVDREETPSFLITCRALNA-QGLDVEKPLILTVKILDINDNPPVFS 158
F++D+NTGDI+ T +DREE + + +AL+ VE +KI DINDN P F
Sbjct: 95 FIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFL 154
Query: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGE 217
+ + E S + V+ + ATDAD+P + NS ++ + I+ G P F + TG
Sbjct: 155 DGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQ----GQPYFSVEPKTGV 210
Query: 218 VRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSAR 275
++T ++DRE Y LV+ D G+ GLS + + DVNDN P F Y
Sbjct: 211 IKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYN 270
Query: 276 IEENI-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA 334
+ E++ ++S + R + D D N Y G+ F+I D T EGI+ + K
Sbjct: 271 VPESLPVASVVARIKAADAD--IGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKE 328
Query: 335 LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQK 394
LD+E S L I NK + + +T V I V +V E F +S + ++
Sbjct: 329 LDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVF--SSPLYPME- 385
Query: 395 GISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDG--GYLMIDSKTAEIKFVKNMNR 452
+S V I+GT A D D++ S V+Y + RN Y ID+ + I K+++R
Sbjct: 386 -VSEATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDR 442
Query: 453 DSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLE-KDAVC-SSSPSVV 510
++ I N T+ A G+ G V + + D NDN P ++ + VC ++ P V
Sbjct: 443 ETNAIHNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQV 499
Query: 511 VSA----------------RTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQ 554
+ +L T + F+L+D ++ +T N R Q
Sbjct: 500 IQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASI--LTRRNG----FRRQ 553
Query: 555 EQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSG 614
EQ VY++ + + DS + +LT+ VC CD G+ T Y P
Sbjct: 554 EQ---SVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVA-----QTCNAEAYVLP--A 603
Query: 615 RLGPAAIGLLLLGLLLLLLAPLLLLT 640
L A+ +L +L LL+ LL++T
Sbjct: 604 GLSTGALIAILACVLTLLVLILLIVT 629
Score = 30.4 bits (67), Expect = 8.7
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 801 AEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEI 859
A+ D G D L Y EG + + S+ S +D D +L GP+FK+LA++
Sbjct: 718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYD-YLSDWGPRFKRLADM 775
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 181 bits (459), Expect = 3e-45
Identities = 175/619 (28%), Positives = 284/619 (45%), Gaps = 49/619 (7%)
Query: 42 QAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIF 100
+ R KR WV E + K+ S+ + + Y ++G G IF
Sbjct: 46 EVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGT----IF 101
Query: 101 VVDKNTGDINITAIVDREETPSFLITCRALNAQG---LDVEKPLILTVKILDINDNPPVF 157
++D TGDI+ T +DRE+ +++ +A++ + L+ E I +K+ DINDN P F
Sbjct: 102 IIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFI--IKVQDINDNAPKF 159
Query: 158 SQQIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTG 216
+ ++ + E S + V+ + ATDAD+P + NS ++ + I+ G P F + TG
Sbjct: 160 TDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQ----GQPYFSVDPKTG 215
Query: 217 EVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSA 274
+RT +++DRE Y +V+ D G+ GLS NI + DVNDN P F Y
Sbjct: 216 VIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQL 275
Query: 275 RIEENI-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVK 333
+ E+ + S + + + D D N Y +G+ F I TD T EGIL + K
Sbjct: 276 YVPESAQVGSAVGKIKANDADT--GSNADMTYSIINGDGMGIFSISTDKETREGILSLKK 333
Query: 334 ALDYEQLQSVKLSIAVKN-KAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTV 392
L+YE+ +S L+I N +F S + ++ +T + I V +V E F S V
Sbjct: 334 PLNYEKKKSYTLNIEGANTHLDFRFSHLGPFK-DATMLKIIVGDVDEPPLFSMPSYLMEV 392
Query: 393 QKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRN--DGGYLMIDSKTAEIKFVKNM 450
+ + ++GT A D D+ S V+Y + N D + ID+ T I+ K +
Sbjct: 393 YENAK----IGTVVGTVLAQDPDSTN--SLVRYFINYNVEDDRFFNIDANTGTIRTTKVL 446
Query: 451 NRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVC--SSSPS 508
+R+ T N T+TA + + S TV +RV D NDN P E D + +S P
Sbjct: 447 DREETPWYNITVTASEI---DNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPG 503
Query: 509 VV---VSARTLNNRYTGP-YTFALEDQ-PVKLPAVWSITTLNATSALLRAQ--EQIPPGV 561
V +SA ++ GP + F L+++ PV N S L R + + V
Sbjct: 504 QVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDV 563
Query: 562 YHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAI 621
Y++ ++++D +LT+ VC C+ G T + S L A+
Sbjct: 564 YYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLS-------SAGLSTGAL 616
Query: 622 GLLLLGLLLLLLAPLLLLT 640
+LL +L+LL +L +T
Sbjct: 617 IAILLCVLILLAIVVLFIT 635
Score = 32.7 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 793 FSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPK 852
F ++ A A+ D D L Y EG + + S+ + +D D +L GP+
Sbjct: 715 FIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQ-DYHYLGDWGPE 773
Query: 853 FKKLAEISLGVDGE 866
FKKLAE+ ++ E
Sbjct: 774 FKKLAELYGEIESE 787
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 176 bits (445), Expect = 1e-43
Identities = 164/592 (27%), Positives = 263/592 (44%), Gaps = 42/592 (7%)
Query: 23 GELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQ- 81
G LR G +++ + Q +R KR WV E + ++ SD +
Sbjct: 29 GHLRPSFHGHHEKGKEG--QVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDG 86
Query: 82 KITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQ-GLDVEKP 140
I Y +SG G IFV+D +G+I+ T +DREE + + +A++ +E P
Sbjct: 87 NIKYILSGEGAGT----IFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPP 142
Query: 141 LILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIV 199
VK+ DINDNPP F + + + E S + V+ + A+DAD+P + NS K+ + I+
Sbjct: 143 SEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL 202
Query: 200 SQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKV 257
G P F + TG +RT ++DRE Y +V+ D G GLS + I +
Sbjct: 203 E----GQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITL 258
Query: 258 KDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFE 317
DVNDN P F S Y + E + E + +V D + +N L Y G+ FE
Sbjct: 259 TDVNDNPPKFPQSVYQMSVSEAAVPGEEVG-RVKAKDPDIGENGLVTYNIVDGDGMESFE 317
Query: 318 IQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQST-PVTIQVIN 376
I TD T EG++K+ K +D+E ++ L + N IS + T V I V +
Sbjct: 318 ITTDYETQEGVIKLKKPVDFETKRAYSLKVEAAN-VHIDPKFISNGPFKDTVTVKISVED 376
Query: 377 VREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGY 434
E F S VQ+ ++ +V G A D D A S ++Y + R+ +
Sbjct: 377 ADEPPMFLAPSYIHEVQENAAAGTVV----GRVHAKDPDA--ANSPIRYSIDRHTDLDRF 430
Query: 435 LMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPT 494
I+ + IK K ++R+ T +N T+ A + K V +RV D NDN P
Sbjct: 431 FTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKV---PVAIRVLDVNDNAPK 487
Query: 495 -------AVLEKDAV--CSSSPSVVVSARTLNNRYTGP-YTFALEDQPVKLPAVWSITTL 544
+ E D S+ P V +SA ++ GP + F+L + + P
Sbjct: 488 FAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNR 547
Query: 545 NATSALLRAQ---EQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRG 593
+ T+ + + + +Y + +V++D +LT++VC CD G
Sbjct: 548 DNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNG 599
Score = 34.3 bits (77), Expect = 0.60
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 801 AEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEI 859
A+ D D + IY EG + + S+ + DLD +L + GP+FKKLA++
Sbjct: 728 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESAT-TDSDLDYDYLQNWGPRFKKLADL 785
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 174 bits (441), Expect = 4e-43
Identities = 161/609 (26%), Positives = 278/609 (45%), Gaps = 43/609 (7%)
Query: 46 RQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIFVVDK 104
R KR W+ E S + K+ SD + + Y +SG G +F++++
Sbjct: 50 RSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFIINE 105
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQ-GLDVEKPLILTVKILDINDNPPVFSQQIFM 163
NTGDI T +DREE P +++ +A+N + G VE +KI DINDN P+F+++++
Sbjct: 106 NTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYT 165
Query: 164 GEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGEVRTLT 222
+ E S + V+ + ATDAD+P + NS K+ + I+ G P F + TG ++T
Sbjct: 166 ATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQ----GQPYFSVESETGIIKTAL 221
Query: 223 NSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI-EEN 279
++DRE Y++V+ D G+ GLS NI + DVNDN P F S Y + E +
Sbjct: 222 LNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESS 281
Query: 280 ILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQ 339
+ + R + +D D +N Y T G + F++ TD T EGI+ V K LD+E+
Sbjct: 282 PPGTPIGRIKASDAD--VGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEK 339
Query: 340 LQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK 399
+ L + N + + S V I V +V E F + +++
Sbjct: 340 KKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQ-- 397
Query: 400 KLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGYLMIDSKTAEIKFVKNMNRDSTFI 457
++ +G+ A D D A + VKY + R+ IDS I K ++R++
Sbjct: 398 --INTTIGSVTAQDPDA--ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLW 453
Query: 458 VNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPT-AVLEKDAVCSSSPS----VVVS 512
N T+ A + ++S +Y++V D NDN P A + VC + + +
Sbjct: 454 HNITVIATEI---NNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLH 510
Query: 513 ARTLNNRYTG-PYTFALEDQPVKLPAVWSITTLNATSALL---RAQEQIPPGVYHISLVL 568
A ++ Y+G ++F+L + + T+ +L + Y + +V+
Sbjct: 511 AVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVI 570
Query: 569 TDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGL 628
+D+ ++T+ VC CD+ G + + H L A+ +LL +
Sbjct: 571 SDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAE-------ALIHPTGLSTGALVAILLCI 623
Query: 629 LLLLLAPLL 637
++LL+ +L
Sbjct: 624 VILLVTVVL 632
Score = 35.0 bits (79), Expect = 0.35
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 5/58 (8%)
Query: 811 DCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSF--LDSLGPKFKKLAEISLGVDGE 866
D L Y EG TGS S+ + D D + L GP+FKKLA++ GVD +
Sbjct: 733 DSLATYAYEG---TGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSD 787
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 173 bits (439), Expect = 6e-43
Identities = 161/575 (28%), Positives = 265/575 (46%), Gaps = 54/575 (9%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQ-KITYRISGVGIDQPPFGIFVVD 103
+R KR WV E S+ + K+ SD + + Y +SG G +F +D
Sbjct: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTID 105
Query: 104 KNTGDINITAIVDREETPSFLITCRALNAQGLDVE--KPLI----LTVKILDINDNPPVF 157
+ TGDI+ +DREE P + L AQ +D+E KPL +K+ DINDN P F
Sbjct: 106 ETTGDIHAIRSLDREEKPFY-----TLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKF 160
Query: 158 SQQIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTG 216
++ + E S + V+ + ATDAD+P + NS ++ + I+ G P F + TG
Sbjct: 161 LDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQ----GQPYFSIDPKTG 216
Query: 217 EVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSA 274
+RT ++DRE Y++++ D G+ GL+ NI + DVNDN P F S +
Sbjct: 217 VIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHL 276
Query: 275 RI-EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVK 333
++ E + + S + R + D D + N Y G+ GN F+I TD T EG++K+ K
Sbjct: 277 KVPESSPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKK 334
Query: 334 ALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQ 393
LD+E ++ + N H+ + + V I V++V E F T V
Sbjct: 335 PLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVY 394
Query: 394 KGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMG-RNDG-GYLMIDSKTAEIKFVKNMN 451
+ V I+G A D D +A V+Y + ++DG Y ID I + ++
Sbjct: 395 EDTP----VGTIIGAVTAQDLDVGSSA--VRYFIDWKSDGDSYFTIDGNEGTIATNELLD 448
Query: 452 RDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCP-TAVLEKDAVC-SSSPSV 509
R+ST N +I A ++ T K + + + V D N+ P +V + AVC ++ P
Sbjct: 449 RESTAQYNFSIIASKVSNPLLTSKVN---ILINVLDVNEFPPEISVPYETAVCENAKPGQ 505
Query: 510 VVSARTLNNRYTGP----YTFALEDQPVKLPAVWSITTLNATSAL-------LRAQEQIP 558
++ + +R P ++F L + P N T+ + R Q+++
Sbjct: 506 IIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQEL- 564
Query: 559 PGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRG 593
Y + +V+ DS ++T+ VC+CD+ G
Sbjct: 565 ---YFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDG 596
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 168 bits (425), Expect = 3e-41
Identities = 167/620 (26%), Positives = 276/620 (44%), Gaps = 51/620 (8%)
Query: 42 QAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIF 100
Q+ +R KR WV E + + K+ SD + I Y +SG G +F
Sbjct: 52 QSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI----VF 107
Query: 101 VVDKNTGDINITAIVDREETPSFLITCRALNAQ-GLDVEKPLILTVKILDINDNPPVFSQ 159
+D TGDI+ +DREE + + +AL+ + G +E +KI DINDN P F
Sbjct: 108 TIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLD 167
Query: 160 QIFMGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGEV 218
++ + E S + V+ + ATDAD+P + NS ++ + I+ G P F + TG +
Sbjct: 168 GPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ----GQPYFSVDSKTGVI 223
Query: 219 RTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI 276
RT ++DRE Y +++ D G+ GL+ NI + DVNDN P F Y +
Sbjct: 224 RTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSV 283
Query: 277 EENI-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKAL 335
E+ +SS + R DLDE N Y G+ + F+I TDP GI+ V K L
Sbjct: 284 LESAPISSTVGRVFAKDLDEGI--NAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPL 341
Query: 336 DYEQLQSVKLSIAVKN-KAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQK 394
+E +S L + N E + ++ +T V I V +V E F P V +
Sbjct: 342 SFESKKSYTLKVEGANPHLEMRFLNLGPFQ-DTTTVHISVEDVDEPPVFEPGFYFVEVPE 400
Query: 395 GISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGYLMIDSKTAEIKFVKNMNR 452
++ + I +D + ++++Y + R+ G + +D T + + ++R
Sbjct: 401 DVAIGTTIQIISA------KDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDR 454
Query: 453 DSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDA-VCSSSPS--- 508
+ N T+ A + G V ++V D NDN P +A VC ++ +
Sbjct: 455 EEFSWHNITVLAMEMNNPSQVGSV---PVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQL 511
Query: 509 -VVVSARTLNNRYTGP-YTFALEDQPVKLPAVWSITTLNATSALL------RAQEQIPPG 560
VSA ++ G + ++L + P + T+ +L R QEQ
Sbjct: 512 IQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQ---S 568
Query: 561 VYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAA 620
V+H+ +++ DS +LT++VC CD+ G + P Y P S L A
Sbjct: 569 VFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEA-----YMLPVS--LSRGA 621
Query: 621 IGLLLLGLLLLLLAPLLLLT 640
+ +L + +LL+ LL+L+
Sbjct: 622 LIAILACIFVLLVLVLLILS 641
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 167 bits (423), Expect = 5e-41
Identities = 166/608 (27%), Positives = 271/608 (44%), Gaps = 45/608 (7%)
Query: 46 RQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIFVVDK 104
RQKR W+ E S + K+ SD + + Y +SG G +F++D+
Sbjct: 51 RQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGT----LFIIDE 106
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQGL-DVEKPLILTVKILDINDNPPVFSQQIFM 163
TGDI+ T +DREE + + +A+N + L VE +KI DINDN P F ++I+
Sbjct: 107 KTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYT 166
Query: 164 GEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGEVRTLT 222
+ E S + V+ + ATDAD+P++ NS ++ + I+ G P F + TG +RT
Sbjct: 167 ASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQ----GQPYFSVEPETGIIRTAL 222
Query: 223 NSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI-EEN 279
+++RE Y++V+ D G+ GLS NI + DVNDN P F + R+ E +
Sbjct: 223 PNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESS 282
Query: 280 ILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQ 339
+ + + + TD D N Y G+ + F+I T+ T EGI+ V K LDYE
Sbjct: 283 PVGTAIGSVKATDADT--GKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYES 340
Query: 340 LQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK 399
+ L + +N + +T V I + +V E F +S F V + I
Sbjct: 341 RRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIE-- 398
Query: 400 KLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGYLMIDSKTAEIKFVKNMNRDSTFI 457
V I+GT A D D+ +S +++ + R+ I S + K ++R+ +
Sbjct: 399 --VGTIIGTVMARDPDS--ISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQW 454
Query: 458 VNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPT-AVLEKDAVCSSS-PSVVVSART 515
N T+ A + + T + + V+VR+ D NDN P AV VC ++ P ++ +
Sbjct: 455 HNLTVIAAEINNPKETTRVA---VFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTIS 511
Query: 516 LNNR--YTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQ--EQIPPGVYHISLVLTDS 571
++ G F V N L R + Y + +V++D+
Sbjct: 512 AVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDN 571
Query: 572 QNNRCEMPRSLTLEVCQCDNRG---ICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGL 628
+LT+ VC CD++G C G G A I +LL +
Sbjct: 572 DYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTG---------ALIAILLCII 622
Query: 629 LLLLLAPL 636
+LL++ L
Sbjct: 623 ILLVIVVL 630
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 165 bits (417), Expect = 2e-40
Identities = 159/612 (25%), Positives = 275/612 (44%), Gaps = 48/612 (7%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIFVVD 103
RR KR W+ E + + K+ +D + + Y ++G G +FV+D
Sbjct: 49 RRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGS----LFVID 104
Query: 104 KNTGDINITAIVDREETPSFLITCRALNAQ-GLDVEKPLILTVKILDINDNPPVFSQQIF 162
+NTGDI+ +DREE +++ +A++ + G VE +KI DINDN P F++ ++
Sbjct: 105 ENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLY 164
Query: 163 MGEIEENSASNSLVMILNATDADEPNHLNS-KIAFKIVSQEPAGTPMFLLSRNTGEVRTL 221
+ E S + V+ + ATDAD+ N+ NS K+ + I+ G P F + +G ++T
Sbjct: 165 TASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQ----GQPYFSVDPESGIIKTA 220
Query: 222 TNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARIEEN 279
+ RE Y++V+ D G+ GLS NI + DVN+N P F S Y E+
Sbjct: 221 LPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPES 280
Query: 280 I-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYE 338
+ L + L R + D D +N Y G+ + F++ TD T EGI+ V + LD+E
Sbjct: 281 VPLGTHLGRIKANDPD--VGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFE 338
Query: 339 QLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISS 398
L + N + + + V I V ++ E F S V + +
Sbjct: 339 NQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKE 398
Query: 399 KKLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGYLMIDSKTAEIKFVKNMNRDSTF 456
I+G A D D + +KY + R+ I S+ I +K ++R+S+
Sbjct: 399 GS----IIGQVTAYDPDARN--NLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSP 452
Query: 457 IVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPT-AVLEKDAVC-SSSPSVVVSAR 514
N T+TA + ++S V++R+ D ND+ P A+ + VC ++ P ++
Sbjct: 453 WHNITVTATEI---NNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTV 509
Query: 515 TLNNRYTGP--YTFALEDQP--VKLPAVWSITTLNATSALLRAQE---QIPPGVYHISLV 567
++ ++ P + F E P P + + T+ ++ ++ + Y + ++
Sbjct: 510 SVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPIL 569
Query: 568 LTDSQNNRCEMPRSLTLEVCQCDNRG---ICGTSYPTTSPGTRYGRPHSGRLGPAAIGLL 624
+ D+ +LT+ VC CDN+G C S G G A + +L
Sbjct: 570 IFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTG---------ALVAIL 620
Query: 625 LLGLLLLLLAPL 636
L L+LL+L L
Sbjct: 621 LCVLILLILVVL 632
Score = 32.0 bits (71), Expect = 3.0
Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 802 EEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIAD-DLDDSFLDSLGPKFKKLAEIS 860
+ D D L Y EG D+ + S+ S AD + D +L GP+FKKLA++
Sbjct: 724 DADPSAPPYDSLATYAYEGNDSIADSLSSLE--SLTADCNQDYDYLSDWGPRFKKLADMY 781
Query: 861 LGVDGE 866
G D +
Sbjct: 782 GGDDSD 787
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 164 bits (416), Expect = 3e-40
Identities = 212/842 (25%), Positives = 348/842 (41%), Gaps = 99/842 (11%)
Query: 46 RQKREWVKFAKPCREGEDNSKRNPIAKITSDY-QATQKITYRISGVGIDQPPFGIFVVDK 104
R KR WV E ++ + KI SD + I Y ISG G IF++D+
Sbjct: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114
Query: 105 NTGDINITAIVDREETPSFLITCRALN-AQGLDVEKPLILTVKILDINDNPPVFSQQIFM 163
TGDI+ +DRE+ + + +A + A +E +K+ DIND+ P F ++
Sbjct: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
Query: 164 GEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTN 223
G + E S + + VM + A+DAD+P + +S ++V G F + TG +RT
Sbjct: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSA---RLVYSVLDGEHHFTVDPKTGVIRTAVP 231
Query: 224 SLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENI- 280
LDRE Y +V+ D G+ GLS I V DVNDN P F Y I+E+
Sbjct: 232 DLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAP 291
Query: 281 LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQL 340
+ + + R + D D + S + G+ F++ TD T E I+ V K LD+E
Sbjct: 292 IGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQ 351
Query: 341 QSVKLSIAVKNK-AEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK 399
+ + NK + + + +R Q+ V + V +V E FRP S VQ+
Sbjct: 352 PVHTVILEALNKFVDPRFADLGTFRDQAI-VRVAVTDVDEPPEFRPPSGLLEVQEDAQVG 410
Query: 400 KLVDYILGTYQAIDEDTNKAASNVKYVMGRND--GGYLMIDSKTAEIKFVKNMNRDSTFI 457
LV + D + A V+Y + R ID+ T I K ++R++
Sbjct: 411 SLVGVVTA------RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGW 464
Query: 458 VNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCP-TAVLEKDAVC-SSSPSVVVSART 515
N T+ A + D + + S ++ +R+ D NDN P A + AVC + P ++ +
Sbjct: 465 HNITVLA--MEADNH-AQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTIS 521
Query: 516 LNNRYTGP----YTFALEDQPVKLPAVWSITTLNATSAL------LRAQEQIPPGVYHIS 565
+ +R + F L + P + + T+A+ QEQ V+ +
Sbjct: 522 VVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQ---DVFFLP 578
Query: 566 LVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLL 625
+++ DS +LT+ +C CD+ G + T + L P A+ LL
Sbjct: 579 ILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAF-------VMAASLSPGALIALL 631
Query: 626 LGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNIC 685
+ +L+L++ LL+LT H+ + ED
Sbjct: 632 VCVLILVVLVLLILTL----------------------RRHHKSHLSSDEDED------- 662
Query: 686 VPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGA 745
M + + N G + T +M+ L + + G G G +G
Sbjct: 663 -----------MRDNVIKYND--EGGGEQDTEAYDMSA-LRSLYDFGELKGGDGGGSAGG 708
Query: 746 ASGFGAATGVGICSSGQSGTMRTRHS-TGGTNKDYADGAISMNFLDSYFSQKAFACAEED 804
+G G+ G G S Q+ RHS G D ++ +F+ + A A+ D
Sbjct: 709 GAGGGSGGGAG--SPPQAHLPSERHSLPQGPPSPEPDFSVFRDFI-----SRKVALADGD 761
Query: 805 DGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVD 864
D Y EGAD+ + + S+ S + D ++L S GP+F+ LA + G
Sbjct: 762 LSVPPYDAFQTYAFEGADSPAASLSSLHSGS-SGSEQDFAYLSSWGPRFRPLAALYAGHR 820
Query: 865 GE 866
G+
Sbjct: 821 GD 822
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 162 bits (409), Expect = 2e-39
Identities = 133/455 (29%), Positives = 225/455 (49%), Gaps = 26/455 (5%)
Query: 45 RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDK 104
RRQKR+W+ E ++ S + + KI S + + Y + G + + +F VD
Sbjct: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSV-SRKNAKYLLKGEYVGK----VFRVDA 97
Query: 105 NTGDINITAIVDREETPSFLITCRALNAQ-GLDVEKPLILTVKILDINDNPPVFSQQIFM 163
TGD+ +DRE + +T ++ G ++E P T+K+ D+NDN PVF+ ++F
Sbjct: 98 ETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFN 157
Query: 164 GEIEENSASNSLVMILNATDADEPN-HLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLT 222
+ E+SA + V+ + A DAD+P ++ + ++I+ G F + N+G + T+T
Sbjct: 158 ASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK----GKEYFAID-NSGRIITIT 212
Query: 223 NSLDREQASSYRLVVSGADKDG-EGLSTQCECNIKVKDVNDNFPMFRDSQYSARI-EENI 280
SLDRE+ + Y +VV D G G S + ++D+NDNFP F ++Y+ + E+
Sbjct: 213 KSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTR 272
Query: 281 LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQL 340
+ + + V D DE N + Y G+ + F I+T+P NEGI+K +K LDYE +
Sbjct: 273 VGTSVGSLFVEDPDE--PQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYI 330
Query: 341 QSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKK 400
Q + + +S V I + +V E F+ F +++ + KK
Sbjct: 331 QQYSFIVEATDPT-IDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKE--NQKK 387
Query: 401 LVDYILGTYQAIDEDTNKAASNVKYVMGR-NDGGYLMIDSKTAEIKFVKNMNRDSTFIVN 459
++GT A+D D A ++ Y + R +D G +K +I K ++R+ N
Sbjct: 388 ---PLIGTVLAMDPDA--ARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYN 442
Query: 460 KTITAEVL-AIDEYTGKTSTGTVYVRVPDFNDNCP 493
T+ A+ L + TGK S V++ V D NDN P
Sbjct: 443 LTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP 477
Score = 50.8 bits (120), Expect = 6e-06
Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 145 VKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPA 204
+ I D+ D PP+F Q + +++EN + +L A D D H I + I
Sbjct: 361 INITDV-DEPPIFQQPFYHFQLKENQKKPLIGTVL-AMDPDAARH---SIGYSIRRTSDK 415
Query: 205 GTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCEC----NIKVKDV 260
G F G++ LDRE Y L V + D G T E +I+V D
Sbjct: 416 G--QFFRVTKKGDIYN-EKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDE 472
Query: 261 NDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYT 298
NDN P F Y ++ EN + +L+ Q++ +D++ T
Sbjct: 473 NDNAPEFA-KPYQPKVCENAVHGQLV-LQISAIDKDIT 508
Score = 37.7 bits (86), Expect = 0.054
Identities = 22/59 (37%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 801 AEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEI 859
A+ D D L IY EG+++ + S+G S +D +D FL+ GP+FK LAE+
Sbjct: 716 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSD-VDYDFLNDWGPRFKMLAEL 773
>gi|221316595 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 159 bits (402), Expect = 1e-38
Identities = 169/603 (28%), Positives = 267/603 (44%), Gaps = 67/603 (11%)
Query: 53 KFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINIT 112
K KP E+++ +PI KIT Y + V ++ P F +D+ GDI +T
Sbjct: 240 KAPKPVEMVENSTDPHPI-KITQVRWNDPGAQYSL--VDKEKLPRFPFSIDQE-GDIYVT 295
Query: 113 AIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSAS 172
+DREE +++ A + G + PL + VK+ DINDNPP + + E++EN
Sbjct: 296 QPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERL 355
Query: 173 NSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPM---FLLSRNTGEVRTLTNSLDREQ 229
+ + L A D DE N NS + ++IV Q P PM FL+ G ++ SL ++
Sbjct: 356 GNSIGTLTAHDRDEENTANSFLNYRIVEQTPK-LPMDGLFLIQTYAGMLQLAKQSLKKQD 414
Query: 230 ASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYS--ARIEENILSSELLR 287
Y L + +DKD T C I V D+ND P+F S Y E+ + S +L
Sbjct: 415 TPQYNLTIEVSDKD---FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILT 471
Query: 288 FQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSI 347
Q TD DE +T + +Y G+ + TDP TN G + + K LD+E +
Sbjct: 472 IQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFE-------TA 524
Query: 348 AVKN---KAEFHQSVI--SRYRVQS-TPVTIQVINVREGIAFRPASKTFTVQKGISSKKL 401
AV N KAE + ++ +Y S T+ V +V E P Q +S
Sbjct: 525 AVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEA----PQFSQHVFQAKVSEDVA 580
Query: 402 VDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKT 461
+ +G A D + ++ Y + + G+L ID T EI V ++R++
Sbjct: 581 IGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSP 632
Query: 462 ITAEVLAIDEYTGKTSTGTV---YVRVPDFNDNCPTAVLEKDAV----CS--SSPSVVVS 512
+V+A + G +S +V ++ + D NDN P L KD C S+P ++
Sbjct: 633 YRVQVVATE--VGGSSLSSVSEFHLILMDVNDNPPR--LAKDYTGLFFCHPLSAPGSLIF 688
Query: 513 ARTLNNR--YTGP-YTFALEDQPVKLPAVWSITTLNATSALLRAQE-QIPPGVYHISLVL 568
T +++ + GP +TF+L L W ++ +N T A L + + Y + + +
Sbjct: 689 EATDDDQHLFRGPHFTFSLGSG--SLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRI 746
Query: 569 TDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGL 628
D E SL + C C G C G + G P G A+G+LL L
Sbjct: 747 NDGGRPPLEGIVSLPVTFCSC-VEGSC-----FRPAGHQTGIPTVG----MAVGILLTTL 796
Query: 629 LLL 631
L++
Sbjct: 797 LVI 799
Score = 81.3 bits (199), Expect = 4e-15
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 6/152 (3%)
Query: 99 IFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFS 158
IFV+++ G + +DRE + + AL+A G+ VE P+ +T+K+ DINDN P F
Sbjct: 69 IFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
Query: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPA--GTPMFLLSRNTG 216
Q + G + +NS + +NATD D+P N ++ ++IV Q P F ++ TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
Query: 217 EV---RTLTNSLDREQASSYRLVVSGADKDGE 245
+ R + L+ + SY LV+S D G+
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQ 219
Score = 57.4 bits (137), Expect = 7e-08
Identities = 84/386 (21%), Positives = 146/386 (37%), Gaps = 56/386 (14%)
Query: 177 MILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTL--------TNSLDRE 228
M + + EP S+I F+ + PA T F L+ T + + +LDRE
Sbjct: 34 MTFSIYEGQEP----SQIIFQFKANPPAVT--FELTGETDNIFVIEREGLLYYNRALDRE 87
Query: 229 QASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSE-LLR 287
S++ L V+ D +G + IKVKD+NDN P F S+Y + +N + L
Sbjct: 88 TRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLY 147
Query: 288 FQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSI 347
TDLD+ T N Y IQ L ++ + Y Q+ + +I
Sbjct: 148 VNATDLDDPATPNGQLYYQIV---------IQ---------LPMINNVMYFQINNKTGAI 189
Query: 348 AVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILG 407
++ + P VI+V++ S + T I + +
Sbjct: 190 SLTREGS------QELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK 243
Query: 408 TYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAE-- 465
+ ++ T+ + V + G + K +F +++++ V + + E
Sbjct: 244 PVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEK 303
Query: 466 ------VLAIDEYTGKTSTG-TVYVRVPDFNDNCPTA--------VLEKDAVCSSSPSVV 510
+A DEY S ++V+V D NDN PT V E + + +S ++
Sbjct: 304 DAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLT 363
Query: 511 VSARTLNNRYTGPYTFALEDQPVKLP 536
R N + + +Q KLP
Sbjct: 364 AHDRDEENTANSFLNYRIVEQTPKLP 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,524,198
Number of Sequences: 37866
Number of extensions: 1804814
Number of successful extensions: 9029
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 5851
Number of HSP's gapped (non-prelim): 1237
length of query: 999
length of database: 18,247,518
effective HSP length: 112
effective length of query: 887
effective length of database: 14,006,526
effective search space: 12423788562
effective search space used: 12423788562
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.