Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 119120897
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119120897 par-3 partitioning defective 3 homolog B isoform b
[Homo sapiens]
(1143 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 2325 0.0
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 2002 0.0
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 1642 0.0
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 301 3e-81
gi|148746189 multiple PDZ domain protein [Homo sapiens] 81 6e-15
gi|112382257 InaD-like [Homo sapiens] 72 4e-12
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 68 6e-11
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 67 1e-10
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 67 1e-10
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 67 1e-10
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 65 4e-10
gi|45827729 scribble isoform b [Homo sapiens] 64 6e-10
gi|45827731 scribble isoform a [Homo sapiens] 64 6e-10
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 64 8e-10
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 62 2e-09
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 62 4e-09
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 62 4e-09
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 61 5e-09
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 61 5e-09
gi|87196343 PDZ domain containing 2 [Homo sapiens] 61 7e-09
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 60 9e-09
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 60 9e-09
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 60 9e-09
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 60 1e-08
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 60 1e-08
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 60 1e-08
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 60 2e-08
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 60 2e-08
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 57 8e-08
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 56 2e-07
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo
sapiens]
Length = 1143
Score = 2325 bits (6026), Expect = 0.0
Identities = 1143/1143 (100%), Positives = 1143/1143 (100%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480
Query: 481 RLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAEC 540
RLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAEC
Sbjct: 481 RLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAEC 540
Query: 541 GAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPH 600
GAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPH
Sbjct: 541 GAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPH 600
Query: 601 SALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHS 660
SALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHS
Sbjct: 601 SALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHS 660
Query: 661 LAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFR 720
LAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFR
Sbjct: 661 LAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFR 720
Query: 721 AAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEK 780
AAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEK
Sbjct: 721 AAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEK 780
Query: 781 KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLRE 840
KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLRE
Sbjct: 781 KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLRE 840
Query: 841 EELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREP 900
EELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREP
Sbjct: 841 EELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREP 900
Query: 901 CTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGS 960
CTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGS
Sbjct: 901 CTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGS 960
Query: 961 TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQY 1020
TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQY
Sbjct: 961 TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQY 1020
Query: 1021 ASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQH 1080
ASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQH
Sbjct: 1021 ASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQH 1080
Query: 1081 YPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMT 1140
YPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMT
Sbjct: 1081 YPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMT 1140
Query: 1141 AAV 1143
AAV
Sbjct: 1141 AAV 1143
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
sapiens]
Length = 1136
Score = 2002 bits (5187), Expect = 0.0
Identities = 1026/1205 (85%), Positives = 1039/1205 (86%), Gaps = 131/1205 (10%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL G
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
Query: 481 -----------------RLRMNDQLIAVNGESLLG------------------------- 498
+ +ND A G SL G
Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
Query: 499 --------------------KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
Query: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
Query: 599 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 658
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
Query: 659 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 718
HSLAGQKS+ GL SS H +G
Sbjct: 721 HSLAGQKSD----------GLSDKSS-----------------------HSGQG------ 741
Query: 719 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 778
L+ +S+ G L E +++ + K +K +K K
Sbjct: 742 ------------------ALNCESAPQGNSEL--EDMENKARKVKKTKEKEKKKEKGK-- 779
Query: 779 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 838
LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 780 --------LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 831
Query: 839 REEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFR 898
REEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFR
Sbjct: 832 REEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFR 891
Query: 899 EPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTG 958
EPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTG
Sbjct: 892 EPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTG 951
Query: 959 GSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMER 1018
GSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMER
Sbjct: 952 GSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMER 1011
Query: 1019 QYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYP 1078
QYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYP
Sbjct: 1012 QYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYP 1071
Query: 1079 QHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNP 1138
QHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNP
Sbjct: 1072 QHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNP 1131
Query: 1139 MTAAV 1143
MTAAV
Sbjct: 1132 MTAAV 1136
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
sapiens]
Length = 1104
Score = 1642 bits (4252), Expect = 0.0
Identities = 875/1054 (83%), Positives = 889/1054 (84%), Gaps = 108/1054 (10%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL G
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
Query: 481 -----------------RLRMNDQLIAVNGESLLG------------------------- 498
+ +ND A G SL G
Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
Query: 499 --------------------KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
Query: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
Query: 599 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 658
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
Query: 659 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 718
HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
Sbjct: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
Query: 719 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 778
FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
Sbjct: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
Query: 779 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 838
EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
Query: 839 REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 888
REEELEKMKEERE RI +E + + G Y +DDE
Sbjct: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947
Query: 889 PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 934
AR + + R P +A+ R S PR GP P D P +P
Sbjct: 948 -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000
Query: 935 EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 968
GLY + PY+P A P GS R +LR
Sbjct: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032
Score = 419 bits (1077), Expect = e-117
Identities = 191/192 (99%), Positives = 192/192 (100%)
Query: 952 DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1011
+SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL
Sbjct: 913 ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972
Query: 1012 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1071
RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR
Sbjct: 973 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032
Query: 1072 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1131
VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ
Sbjct: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092
Query: 1132 DSRQKNPMTAAV 1143
DSRQKNPMTAAV
Sbjct: 1093 DSRQKNPMTAAV 1104
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 301 bits (770), Expect = 3e-81
Identities = 269/760 (35%), Positives = 364/760 (47%), Gaps = 161/760 (21%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR--------- 529
DGRLR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR
Sbjct: 633 DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692
Query: 530 ------PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGL 581
PE P+E + S + + + RN ++ +G +
Sbjct: 693 PGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTV 751
Query: 582 LLPNDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSG 615
+P D E +PP S + H +G D S S
Sbjct: 752 NMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPD 811
Query: 616 VDSAVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKS 666
VD + F + +S++ R Q + + + SKSMDL + DE+K++++ QK+
Sbjct: 812 VDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKA 871
Query: 667 ESPSKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDK 725
SPS+D GP+LGLKKSSSLESLQTAVAEV N D+PFHRPRP ++RGRGCNESFRAAIDK
Sbjct: 872 GSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDK 931
Query: 726 SYDGP---------EEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTK 776
SYD P E +E D +++SS SG+ +++ S +S M K KT
Sbjct: 932 SYDKPAVDDDDEGMETLEED--TEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKT- 988
Query: 777 EKEKKKEKGKLKVKEKKRKEENEDPERKIKK---KGFGAMLRFGKKKEDKGGKAEQKGTL 833
++KK+K KEKK+ + E + K KK KG G M RFGK ++D K E+ G +
Sbjct: 989 --DRKKDK---TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKD--DKIEKTGKI 1041
Query: 834 K--HGGLREEELEKMKEERERIGAKHQELREKQARGLLDYA-TGAIGSVYDMDDDEMDPN 890
K EEE +MK+E+ERI AK +E RE+QAR DYA + DD+ M
Sbjct: 1042 KIQESFTSEEERIRMKQEQERIQAKTREFRERQARE-RDYAEIQDFHRTFGCDDELM--- 1097
Query: 891 YARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPL-V 949
Y V+ + E + N + P++ PR+GH ++ LYA+V KP +
Sbjct: 1098 YGGVSSY-EGSMALN-----ARPQS-----PREGH-------MMDALYAQVKKPRNSKPS 1139
Query: 950 PADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGR-GPDGNA 1008
P DS R T + DRIQ+LR+E+ QA+++ ED E R R ++ W R
Sbjct: 1140 PVDSNRSTPSNHDRIQRLRQEFQQAKQD-----EDVEDRRRTYSFEQPWPNARPATQSGR 1194
Query: 1009 HNLRFE---------------GMERQYASLPRGG-------PADPVDYLPAAPRGLYKER 1046
H++ E +RQY+SLPR D + + G +
Sbjct: 1195 HSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAK 1254
Query: 1047 ELPYYP----------GAHPMHPPKGSYPRPTELRVADLRYPQH---YPPPPAPQH---- 1089
E P Y G H + + LR R Q PP P +
Sbjct: 1255 ENPRYSSYQGSRNGYLGGHGFN-ARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSY 1313
Query: 1090 -----------KGPFRQDVPPSPPQHQRMPAYQ--ETGRP 1116
KGPFRQDVPPSP Q R+ Q E GRP
Sbjct: 1314 KKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRP 1353
Score = 234 bits (596), Expect = 5e-61
Identities = 143/342 (41%), Positives = 204/342 (59%), Gaps = 23/342 (6%)
Query: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
SASHP G+ L+ D ED E + T L P +L DM + VE+ +
Sbjct: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280
Query: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339
Query: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL
Sbjct: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399
Query: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
T A + D+ + L + P G PS+P+ +P G+ + K
Sbjct: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455
Query: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELD 479
G D+ G++QEE+V++LRSTK T SL++ RQE F PREL+
Sbjct: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
Score = 156 bits (395), Expect = 9e-38
Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD
Sbjct: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P
Sbjct: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
Query: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
EIEVTPS L+ PL VRRSSDP
Sbjct: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146
Score = 38.5 bits (88), Expect = 0.037
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 13/132 (9%)
Query: 152 QPSASHP---GGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISG 208
Q A HP + ++ +P T+ ED +++ LT T++ L+ + SG
Sbjct: 547 QEDAFHPRELNAEPSQMQIPKETK-AEDEDIV-------LTPDGTREFLT-FEVPLNDSG 597
Query: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
G LG+ V S + LG+F++ I + + ++G N+ ++ +N L+ KT
Sbjct: 598 SAG-LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
Query: 269 QAQDVFRQAMKS 280
A + R++M +
Sbjct: 657 DAMETLRRSMST 668
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 80.9 bits (198), Expect = 6e-15
Identities = 39/74 (52%), Positives = 54/74 (72%)
Query: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
I L++GP+GLGF++V S HG PI+VK + KGAA +DGRL+ GD+I+ VNG+ + G
Sbjct: 1959 ITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEG 2018
Query: 444 RTQEELVAMLRSTK 457
T EE VA+L+ TK
Sbjct: 2019 VTHEEAVAILKRTK 2032
Score = 72.0 bits (175), Expect = 3e-12
Identities = 76/338 (22%), Positives = 150/338 (44%), Gaps = 45/338 (13%)
Query: 167 VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225
+P +++NL+++E + + TS D S + +E+ + G LGI + S
Sbjct: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500
Query: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
+ G+ I+ + ++ + +G + I+ +++ +V + + + A + + +
Sbjct: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Query: 286 HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345
H P + Q S G+ + K+ ++ + + SPE ++
Sbjct: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602
Query: 346 SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405
+ ++ +P + S P+ P++ + I++ KG GLG ++V ++
Sbjct: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651
Query: 406 GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
G I + + +GAA KDGRL +GD+ILEVNG D+ T +E + +LR T Q L
Sbjct: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707
Query: 466 IARQEGHFLPRELDGRLRMNDQLIAVN--GESLLGKSN 501
+ R E + E+ L + Q G S++GK N
Sbjct: 1708 LYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN 1745
Score = 67.0 bits (162), Expect = 1e-10
Identities = 66/281 (23%), Positives = 111/281 (39%), Gaps = 69/281 (24%)
Query: 203 TVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDL 262
T+E+ +G LG F + G+ G+ ++ I + + G + I+KI + DL
Sbjct: 257 TIELVNDGSGLG------FGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDL 310
Query: 263 VDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV 322
+ Q V RQ +++ G ++ + P
Sbjct: 311 AGMSSEQVAQVLRQCGNRVKLMIA------------------------RGAIEERTAPTA 346
Query: 323 HGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI 382
G T + + T +PE AS Q+ + ++
Sbjct: 347 LGI----TLSSSPTSTPELRVDASTQKGEE--------------------------SETF 376
Query: 383 KIDLKKGPEGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
++L K +GLG T+ D + P IFVK+I A DGR+Q GD+I+ V+G +
Sbjct: 377 DVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTN 435
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEGHFLPRE 477
+ G T ++ V +LR T G+T L + R QE + RE
Sbjct: 436 LQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSRE 474
Score = 67.0 bits (162), Expect = 1e-10
Identities = 84/308 (27%), Positives = 139/308 (45%), Gaps = 40/308 (12%)
Query: 174 LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228
L +RE G ++EL T + + R VE+ E LGI +V S LS G +
Sbjct: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
Query: 229 L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285
+ G+FI+ + ++S + + G + IV+++ +DL D + QA + R+A +P V +
Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240
Query: 286 --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337
LP Y K S N F ++ + K P +S + A L
Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298
Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387
P A A + + + + S + FG S KN ++ I+L+
Sbjct: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 388 KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
KG GLG ++ +D S +F+ I P GAA KDGRLQ D +LE+NG+ + GR+
Sbjct: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411
Query: 447 EELVAMLR 454
+ ++++
Sbjct: 1412 QNASSIIK 1419
Score = 62.4 bits (150), Expect = 2e-09
Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%)
Query: 202 RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
RT+ I+ LG+ V S + LG+ +R I R+G +CI+ IN
Sbjct: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
Query: 262 LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314
+ T AQA+ + R+ ++ P + + +P ++ E+++ S+ + +L+IF + G
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
++P G+ + E +A N+ PR L +PS
Sbjct: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159
Query: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434
K + I + G G+G +R S+ IF+K++L A K+G L+ GDRI+
Sbjct: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 435 EVNGRDVTGRTQEELVAMLR 454
EV+G D+ + E+ V +R
Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229
Score = 62.0 bits (149), Expect = 3e-09
Identities = 95/428 (22%), Positives = 169/428 (39%), Gaps = 51/428 (11%)
Query: 65 LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124
L + ++D L V + H + + G A + E+ PI I +
Sbjct: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548
Query: 125 TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184
+A K+ L + + P+ ++ S L+VP S E + N +
Sbjct: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606
Query: 185 TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
+ + P T + T+EIS LG+ +V +L G I+ I + +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298
+ ++G + I+++N +DL T +A +V RQ + + L+ P + E +
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
Query: 299 SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336
I L+I G N+ GV + + K G+ A+ + G
Sbjct: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778
Query: 337 D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388
D + +A A+L + + S S S + S KNA +I ++KK
Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838
Query: 389 GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
GP + LG ++ S G PIF+ + P G A + +L+ GDRI+ + G G T
Sbjct: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898
Query: 448 ELVAMLRS 455
+ V +L++
Sbjct: 1899 QAVNLLKN 1906
Score = 58.2 bits (139), Expect = 4e-08
Identities = 53/199 (26%), Positives = 90/199 (45%), Gaps = 14/199 (7%)
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
+ V + + S + L Q ++Q + + NI + L V P + +S L +
Sbjct: 37 KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96
Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
N + +L+ P +P + GKP+ L+ + ++ LK
Sbjct: 97 PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145
Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449
GLGF+VV S G IFV+ I A +DGRL+ D+IL +NG+ + T ++
Sbjct: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205
Query: 450 VAMLRSTKQGETASLVIAR 468
+++L+ K +T LVIAR
Sbjct: 206 ISILQKAK--DTVQLVIAR 222
Score = 53.1 bits (126), Expect = 1e-06
Identities = 32/100 (32%), Positives = 56/100 (56%), Gaps = 6/100 (6%)
Query: 384 IDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
I+L+KG +GLGF+++ I I +++++P G A KDGRL GDR++ VN ++
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760
Query: 443 GRTQEELVAMLR-----STKQGETASLVIARQEGHFLPRE 477
+ EE V L+ + + G L ++ +EG+ +E
Sbjct: 761 NSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKE 800
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/128 (34%), Positives = 61/128 (47%), Gaps = 15/128 (11%)
Query: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400
A SL Q SP V R SPS + + SN I+L GLGF ++
Sbjct: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
Query: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460
++ + VK ILP G A + GRL SGD IL++ D+ G + E++ +LR G
Sbjct: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
Query: 461 TASLVIAR 468
L+IAR
Sbjct: 328 RVKLMIAR 335
Score = 52.0 bits (123), Expect = 3e-06
Identities = 58/280 (20%), Positives = 114/280 (40%), Gaps = 30/280 (10%)
Query: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245
EL T+ T VE++ LGI + + G+F++ I +S + +
Sbjct: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419
Query: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301
G + I+ ++ +L T QA +V R +VLL ++ +++ E + V
Sbjct: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477
Query: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354
++ N ++K S + N+ T+ S E + Q+ ++
Sbjct: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537
Query: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414
+ + +MG N + + + K E G + + H F+++
Sbjct: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580
Query: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
+LP+G G+L SGD +LEVNG + G +++V +L+
Sbjct: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
Score = 43.5 bits (101), Expect = 0.001
Identities = 92/376 (24%), Positives = 139/376 (36%), Gaps = 99/376 (26%)
Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269
G LG VV S G LG+F++ I++ S + R+G E + I+ IN L T Q
Sbjct: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204
Query: 270 AQDVFRQAM---------------------KSPSVLLHVLPPQNREQYEK---------- 298
A + ++A +SPS + N ++
Sbjct: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264
Query: 299 SVIGSLNIFGNNDGVL-KTKVPPPV---HGK--SGLKTANLTGTD----SPETDASASLQ 348
S +G I G GV+ KT +P V HG+ SG + TD S E A Q
Sbjct: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324
Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGF---GSNKNAKKIKIDL--KKGPEGLGFTVVTRDSS 403
++ G + +G S + ++++D +KG E F V
Sbjct: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVE----- 379
Query: 404 IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463
KN+ G I GD+ LE +G V T+ V
Sbjct: 380 -------LTKNVQGLGITIAG---YIGDKKLEPSGIFVKSITKSSAV------------- 416
Query: 464 LVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 523
E DGR+++ DQ+IAV+G +L G +N +A+E LR + Q
Sbjct: 417 -------------EHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTG----------Q 453
Query: 524 LVILRRPERPMEDPAE 539
V+L R M+ AE
Sbjct: 454 TVLLTLMRRGMKQEAE 469
Score = 41.2 bits (95), Expect = 0.006
Identities = 21/49 (42%), Positives = 33/49 (67%), Gaps = 7/49 (14%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 527
DGRL+ DQ+IAVNG+SL G ++ EA+ L+R+ +G + L++L
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040
Score = 40.0 bits (92), Expect = 0.013
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 376 NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435
+K + + I++ KG LG TV + + V++I+ GA +DGR+ GD IL
Sbjct: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056
Query: 436 VNGRDVTGRTQEELVAMLR 454
+N T + AMLR
Sbjct: 1057 INEESTISVTNAQARAMLR 1075
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 71.6 bits (174), Expect = 4e-12
Identities = 91/434 (20%), Positives = 165/434 (38%), Gaps = 95/434 (21%)
Query: 164 KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220
K + DS +N E+ + T + + +D+ +E+ + LG+ +
Sbjct: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254
Query: 221 FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280
+ + +F+ GI + +G + +++INN L ++ A + + A
Sbjct: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
Query: 281 PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327
++ + V P P + + G+ I DG ++ + +S
Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
Query: 328 LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379
+ T S S Q+ P P + + GF + +
Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431
Query: 380 --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ I++ KG GLG ++V +D+ ++ I + + +GAA +DGRL +GD+ILEV
Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRE------------------- 477
NG D+ + EE + LR T Q LV+ R E H+ E
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
Query: 478 -----------------------LDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSM 514
LDGRL DQ+++VNGE + S L+ +
Sbjct: 1547 SIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA--- 1603
Query: 515 EGNIRGMIQLVILR 528
+G++QL I R
Sbjct: 1604 ----QGLVQLEIGR 1613
Score = 60.1 bits (144), Expect = 1e-08
Identities = 64/258 (24%), Positives = 108/258 (41%), Gaps = 74/258 (28%)
Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
G LG VV S G++ +F++ ++ S + R+ EN+ I+ IN+ L D+ +
Sbjct: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
Q + LL + GSL + + PVH KS +
Sbjct: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229
Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
++L T PET +++ ++L
Sbjct: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255
Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
GLGF +V +S + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++
Sbjct: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
Query: 451 AMLRSTKQGETASLVIAR 468
+LR+ G + +++AR
Sbjct: 311 QVLRNC--GNSVRMLVAR 326
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%)
Query: 171 TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227
T L +RE G +T + PR + + ++ IS GG I + L G
Sbjct: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101
Query: 228 ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287
+FI+ + ++S + + + I++++ VDL + + ++A + + A +P V
Sbjct: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154
Query: 288 LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347
++ SL+ +V P VH K+ +TG + +T
Sbjct: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190
Query: 348 QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392
+Q +P P + P +L+ ++A +KI+ I+L+K G
Sbjct: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248
Query: 393 LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
LG ++ +D S IFV I P+G A DGR++ GD +LE+N + + GR+ + A
Sbjct: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
Query: 452 MLRSTKQGETASLVIARQE 470
++++ LV R E
Sbjct: 1306 IIKTAP--SKVKLVFIRNE 1322
Score = 48.5 bits (114), Expect = 4e-05
Identities = 41/147 (27%), Positives = 69/147 (46%), Gaps = 13/147 (8%)
Query: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
L TD T+ + N S P P+LG + + S + + + I I+
Sbjct: 83 LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445
+ GLGF+VV S G IFVK++ P A +D RL+ D+IL +N + +
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 446 QEELVAMLRSTKQGETASLVIARQEGH 472
++ +A+L+ T + L++AR+ H
Sbjct: 199 HQQAIALLQQTT--GSLRLIVAREPVH 223
Score = 43.5 bits (101), Expect = 0.001
Identities = 58/291 (19%), Positives = 118/291 (40%), Gaps = 46/291 (15%)
Query: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249
P + +L + + +G LGI +V + +S +G G++++ I S + G
Sbjct: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
Query: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309
N+ IV ++ V++ + FA V + +++ ++H+ + + S + + G
Sbjct: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
Query: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368
V++ PP + ++T N+ G D + +L+ + + +L P SP
Sbjct: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523
Query: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410
+N K + + GP+ V T D+ I +
Sbjct: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574
Query: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
++ +I+ G G LQ D +LEVNG + G+++ E V+ L+
Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Score = 43.1 bits (100), Expect = 0.001
Identities = 68/338 (20%), Positives = 131/338 (38%), Gaps = 68/338 (20%)
Query: 182 GVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSR 241
G Q L P T + +EIS LG+ +V + + I + +
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIV---GGKDTPLNAIVIHEVYEEGA 1472
Query: 242 SKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-----HVLPPQNREQY 296
+ R+G + I+++N VDL + + +A RQ + +++ H +N E +
Sbjct: 1473 AARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIF 1532
Query: 297 -----EKSVIG-SLNIFG--NNDGVLKTKV----PPPVHGK--SGLKTANLTGTD----S 338
+K+ G L+I G N GV + + + G+ G + ++ G D S
Sbjct: 1533 PVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592
Query: 339 PETDA-----------------------SASLQQNKSPRVPRLGGKPSSPSLSPLM---- 371
ET A SA S + PS +P++
Sbjct: 1593 QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQ 1652
Query: 372 --------------GFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILP 417
G++ + ++I+ ++ + LG ++ S G P+F+ I
Sbjct: 1653 NLVGTKRVSDPSQKNSGTDMEPRTVEIN-RELSDALGISIAGGRGSPLGDIPVFIAMIQA 1711
Query: 418 KGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS 455
G A + +L+ GDRI+ +NG+ + G + ++V +L++
Sbjct: 1712 SGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Score = 33.5 bits (75), Expect = 1.2
Identities = 16/57 (28%), Positives = 31/57 (54%), Gaps = 7/57 (12%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPE 531
P DGR+R+ D+L+ +N + L G+S+ A ++ + S ++LV +R +
Sbjct: 1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KVKLVFIRNED 1323
Score = 32.0 bits (71), Expect = 3.5
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 8/81 (9%)
Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
V LRS G+ V Q G R D RL+ NDQ++A+N L +H+
Sbjct: 149 VVALRSQNLGKVDIFVKDVQPGSVADR--DQRLKENDQILAINHTPLDQNISHQ------ 200
Query: 510 RSMSMEGNIRGMIQLVILRRP 530
+++++ G ++L++ R P
Sbjct: 201 QAIALLQQTTGSLRLIVAREP 221
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 67.8 bits (164), Expect = 6e-11
Identities = 33/74 (44%), Positives = 46/74 (62%)
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
+K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T
Sbjct: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
Query: 446 QEELVAMLRSTKQG 459
++ + + K+G
Sbjct: 280 HQDALQKFKQAKKG 293
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
DA A L+Q + PR + + +P P + S A +
Sbjct: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
Query: 446 QEELVAMLRSTKQGETASLVIARQ 469
+ E ++++ G ++VI R+
Sbjct: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
Score = 45.1 bits (105), Expect = 4e-04
Identities = 19/66 (28%), Positives = 36/66 (54%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
Query: 470 EGHFLP 475
+P
Sbjct: 1199 TPEAMP 1204
Score = 43.9 bits (102), Expect = 9e-04
Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 48/286 (16%)
Query: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
+ T L P S ++ V + G+ LG +V S+ G I G++++ I +
Sbjct: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
Query: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
+G E + I+++N + T A F+QA K L L + R S+
Sbjct: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
Query: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
L+ PP+ +L+ + D+S+ + SP P KP
Sbjct: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
Query: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
+ + +++ L+K G+G V I G IFV + P
Sbjct: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
A DGRL+ GD I+E++ V T E+ +L G +V
Sbjct: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437
Score = 40.0 bits (92), Expect = 0.013
Identities = 23/100 (23%), Positives = 50/100 (50%), Gaps = 13/100 (13%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
DGRL+ D+++ +NGES+ G ++ +A++ +++ +G++ L + R P P+
Sbjct: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PS 308
Query: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILH----PLGTCSP 574
C S P + ++ ++ + + L P+ T P
Sbjct: 309 LCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKP 348
Score = 31.6 bits (70), Expect = 4.5
Identities = 10/33 (30%), Positives = 26/33 (78%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+G ++ ++++++NG+SL G ++H+A+ LR++
Sbjct: 1153 EGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 201 SLEEVTHEEAVAILKNTSE 219
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/251 (25%), Positives = 106/251 (42%), Gaps = 35/251 (13%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK-------SPSV 283
+++ I D ++++G + ++ +NN L + T +A + + + P+
Sbjct: 171 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 230
Query: 284 LLHVLP---PQNREQYEKSVIGSLNIFGNNDGVL--KTKVPPPVHGKSGLKTANLTGTDS 338
+ P P Y + L N+G L KT +PP G+ ++ D
Sbjct: 231 IYMTDPYGPPDITHSYSPPMENHL--LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD- 287
Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV 398
D ++ Q + + R P S + + + K+ L KG GLGF +V
Sbjct: 288 ---DYTSHSQHSTATRQP-----------SMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333
Query: 399 TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458
+ G G IFV IL G A G LQ GD+IL VNG D+ G + E+ A L+
Sbjct: 334 GGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-- 387
Query: 459 GETASLVIARQ 469
G+T +++ Q
Sbjct: 388 GQTVTIIAQYQ 398
Score = 52.0 bits (123), Expect = 3e-06
Identities = 47/173 (27%), Positives = 75/173 (43%), Gaps = 46/173 (26%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 47 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQE---------------------------GHF 473
V+ + + V L+ + G L + R+
Sbjct: 107 VSEVSHSKAVEALK--EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH 164
Query: 474 LP---------------RELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+P + DGRL++ D+L+ VN SL ++ EA+ L+ +
Sbjct: 165 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 217
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 75 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122
Score = 32.7 bits (73), Expect = 2.0
Identities = 14/35 (40%), Positives = 22/35 (62%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
P +L G L+ DQ+++VNG L G S+ +A L+
Sbjct: 351 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385
Score = 30.8 bits (68), Expect = 7.7
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 8/68 (11%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
DGRLR+ND ++ VN + S+ +A+E L+ + G I + +RR +E
Sbjct: 90 DGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVV 141
Query: 539 ECGAFSKP 546
E F P
Sbjct: 142 EIKLFKGP 149
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 297 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 356
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 357 SLEEVTHEEAVAILKNTSE 375
Score = 55.1 bits (131), Expect = 4e-07
Identities = 36/87 (41%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+
Sbjct: 526 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 443 GRTQEELVAMLRSTKQGETASLVIARQ 469
G + E+ A L+ G+T +++ Q
Sbjct: 582 GASHEQAAAALKGA--GQTVTIIAQYQ 606
Score = 52.0 bits (123), Expect = 3e-06
Identities = 47/173 (27%), Positives = 75/173 (43%), Gaps = 46/173 (26%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQE---------------------------GHF 473
V+ + + V L+ + G L + R+
Sbjct: 263 VSEVSHSKAVEALK--EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH 320
Query: 474 LP---------------RELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+P + DGRL++ D+L+ VN SL ++ EA+ L+ +
Sbjct: 321 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 373
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
Score = 32.7 bits (73), Expect = 2.0
Identities = 14/35 (40%), Positives = 22/35 (62%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
P +L G L+ DQ+++VNG L G S+ +A L+
Sbjct: 559 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593
Score = 30.8 bits (68), Expect = 7.7
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 8/68 (11%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
DGRLR+ND ++ VN + S+ +A+E L+ + G I + +RR +E
Sbjct: 246 DGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVV 297
Query: 539 ECGAFSKP 546
E F P
Sbjct: 298 EIKLFKGP 305
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 192 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 251
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 252 SLEEVTHEEAVAILKNTSE 270
Score = 55.1 bits (131), Expect = 4e-07
Identities = 36/87 (41%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+
Sbjct: 421 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 443 GRTQEELVAMLRSTKQGETASLVIARQ 469
G + E+ A L+ G+T +++ Q
Sbjct: 477 GASHEQAAAALKGA--GQTVTIIAQYQ 501
Score = 52.0 bits (123), Expect = 3e-06
Identities = 47/173 (27%), Positives = 75/173 (43%), Gaps = 46/173 (26%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 98 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQE---------------------------GHF 473
V+ + + V L+ + G L + R+
Sbjct: 158 VSEVSHSKAVEALK--EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH 215
Query: 474 LP---------------RELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+P + DGRL++ D+L+ VN SL ++ EA+ L+ +
Sbjct: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 268
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173
Score = 32.7 bits (73), Expect = 2.0
Identities = 14/35 (40%), Positives = 22/35 (62%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
P +L G L+ DQ+++VNG L G S+ +A L+
Sbjct: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488
Score = 30.8 bits (68), Expect = 7.7
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 8/68 (11%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
DGRLR+ND ++ VN + S+ +A+E L+ + G I + +RR +E
Sbjct: 141 DGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVV 192
Query: 539 ECGAFSKP 546
E F P
Sbjct: 193 EIKLFKGP 200
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 65.1 bits (157), Expect = 4e-10
Identities = 49/164 (29%), Positives = 83/164 (50%), Gaps = 11/164 (6%)
Query: 317 KVPPPVHGKSGLKTANL-TGTDSPETDASASLQQNKSPRVPRLGGKP-SSPSLSPLMGFG 374
K+ P++G + N T ++P +A LQQ+ P LG KP +P F
Sbjct: 356 KIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHT-ELGTKPLQAPGFREKPLFT 414
Query: 375 SNKNAKK---IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431
+ + K + LKK G GFT++ D + VK+++P G A +DG++++GD
Sbjct: 415 RDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEF---LQVKSVIPDGPAAQDGKMETGD 471
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
I+ +N V G T ++V + +S G++ +LV+ R G+ LP
Sbjct: 472 VIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCR--GYPLP 513
Score = 49.7 bits (117), Expect = 2e-05
Identities = 26/96 (27%), Positives = 51/96 (53%), Gaps = 5/96 (5%)
Query: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPG-PIFVKNILPKGAAIKDGRLQSGDRI 433
S + K++ + L++ G GF ++ D PG PI + ++ G+A +DGRL GD +
Sbjct: 770 SGPDYKELDVHLRRMESGFGFRILGGDE----PGQPILIGAVIAMGSADRDGRLHPGDEL 825
Query: 434 LEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
+ V+G V G+T ++ ++ + +L + R+
Sbjct: 826 VYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRK 861
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/272 (23%), Positives = 107/272 (39%), Gaps = 52/272 (19%)
Query: 213 LGIHVVPFFSSLSGRILG-------LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK 265
L +H+ S RILG + I + + R+G H + +V ++ + + K
Sbjct: 777 LDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836
Query: 266 TFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGK 325
T D+ A ++ V L V VL P P +G+
Sbjct: 837 THRYVIDLMHHAARNGQVNLTV----------------------RRKVLCGGEPCPENGR 874
Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKID 385
S + T SP +D + N + PSS + SP GF S+ +
Sbjct: 875 SPGSVS--THHSSPRSDYATYTNSNHAA--------PSS-NASPPEGFASHSLQTSDVVI 923
Query: 386 LKKGPEGLGFTVVTRDSSIHGPG-------PIFVKNILPKGAAIKDGRLQSGDRILEVNG 438
+K EG GF ++ SS++ P P + I+ A + +L+ GDRIL VNG
Sbjct: 924 HRKENEGFGFVII---SSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNG 980
Query: 439 RDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
+ + ++V +++ G + +L I QE
Sbjct: 981 QSIINMPHADIVKLIKDA--GLSVTLRIIPQE 1010
Score = 47.4 bits (111), Expect = 8e-05
Identities = 31/119 (26%), Positives = 59/119 (49%), Gaps = 9/119 (7%)
Query: 356 PRLGGKPSSPSLS--PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFV 412
P L + SP PL + ++ +D++KG +G GF++ R+ + ++V
Sbjct: 1118 PLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMD----LYV 1173
Query: 413 KNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
+ G AI++GR++ GD+I+E+NG T + +++S G L++ R G
Sbjct: 1174 LRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLKRGTG 1230
Score = 42.7 bits (99), Expect = 0.002
Identities = 61/257 (23%), Positives = 101/257 (39%), Gaps = 31/257 (12%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP- 289
L ++ + + + ++G + IV IN V ++ T A +F+ SV L +
Sbjct: 450 LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRG 509
Query: 290 ---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV--HGKSGLKT----ANLTGTDSPE 340
P + E S++ L I PPPV +G+ +T + T P+
Sbjct: 510 YPLPFDPEDPANSMVPPLAIMER---------PPPVMVNGRHNYETYLEYISRTSQSVPD 560
Query: 341 TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSN--KNAKKIKIDLKKGPEGLGFTVV 398
+ P +L G P + S+ A+ + + + KG +G GFT+
Sbjct: 561 ITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIA 620
Query: 399 TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458
P VK IL L GD I+E+N ++V + E+V +L+
Sbjct: 621 D------SPTGQRVKQILDIQGC---PGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPI 671
Query: 459 GETASLVIARQEGHFLP 475
G SL+I R G F P
Sbjct: 672 GSETSLIIHR-GGFFSP 687
Score = 31.2 bits (69), Expect = 5.9
Identities = 13/35 (37%), Positives = 23/35 (65%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
P +GR+R+ DQ+I +NGES ++ A+E ++
Sbjct: 1181 PAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 64.3 bits (155), Expect = 6e-10
Identities = 97/414 (23%), Positives = 155/414 (37%), Gaps = 116/414 (28%)
Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
P D P GG L L+ P+S L R V ++E R +
Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874
Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
S GG P+ + +G +F+ I + + R G + ++ IN VD+ +
Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
A + A + ++LL E+ G L PP
Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956
Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
+ L + P + + +P VP L PSL+P + + + ++I+
Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006
Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
+ GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064
Query: 440 DVTGRTQEELVAML-------------------------------------RSTKQGETA 462
DV T +E V+ L R +G
Sbjct: 1065 DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAG 1124
Query: 463 SLVIARQEGHFLPR-------ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
+ EG F+ + DGRLR+ +L+ VN +SLLG ++ EA++ LR
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/108 (34%), Positives = 61/108 (56%), Gaps = 7/108 (6%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLVC-- 1189
Query: 470 EGHFLPRELDGRLRMNDQLIAVNGESLLGKSNH-EAMETLRRSMSMEG 516
+G D L ++ +IA + +G N E++ ++ R +S EG
Sbjct: 1190 DG--FEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
Score = 33.5 bits (75), Expect = 1.2
Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 437 NGRDVTGRTQEELVAMLR 454
NG + G E V LR
Sbjct: 784 NGVALQGAEHHEAVEALR 801
Score = 33.1 bits (74), Expect = 1.5
Identities = 14/28 (50%), Positives = 21/28 (75%)
Query: 482 LRMNDQLIAVNGESLLGKSNHEAMETLR 509
+R+ D+L+ VNG +L G +HEA+E LR
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALR 801
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 64.3 bits (155), Expect = 6e-10
Identities = 97/414 (23%), Positives = 155/414 (37%), Gaps = 116/414 (28%)
Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
P D P GG L L+ P+S L R V ++E R +
Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874
Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
S GG P+ + +G +F+ I + + R G + ++ IN VD+ +
Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
A + A + ++LL E+ G L PP
Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956
Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
+ L + P + + +P VP L PSL+P + + + ++I+
Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006
Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
+ GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064
Query: 440 DVTGRTQEELVAML-------------------------------------RSTKQGETA 462
DV T +E V+ L R +G
Sbjct: 1065 DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAG 1124
Query: 463 SLVIARQEGHFLPR-------ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
+ EG F+ + DGRLR+ +L+ VN +SLLG ++ EA++ LR
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/108 (34%), Positives = 61/108 (56%), Gaps = 7/108 (6%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLVC-- 1189
Query: 470 EGHFLPRELDGRLRMNDQLIAVNGESLLGKSNH-EAMETLRRSMSMEG 516
+G D L ++ +IA + +G N E++ ++ R +S EG
Sbjct: 1190 DG--FEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
Score = 33.5 bits (75), Expect = 1.2
Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 437 NGRDVTGRTQEELVAMLR 454
NG + G E V LR
Sbjct: 784 NGVALQGAEHHEAVEALR 801
Score = 33.1 bits (74), Expect = 1.5
Identities = 14/28 (50%), Positives = 21/28 (75%)
Query: 482 LRMNDQLIAVNGESLLGKSNHEAMETLR 509
+R+ D+L+ VNG +L G +HEA+E LR
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALR 801
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 63.9 bits (154), Expect = 8e-10
Identities = 34/77 (44%), Positives = 50/77 (64%), Gaps = 2/77 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++++L KGP+GLGF++ + H PG I++ I+ GAA KDGRLQ GDR+L VN
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284
Query: 440 DVTGRTQEELVAMLRST 456
++ EE VA L++T
Sbjct: 285 NLQDVRHEEAVASLKNT 301
Score = 57.0 bits (136), Expect = 1e-07
Identities = 68/277 (24%), Positives = 108/277 (38%), Gaps = 70/277 (25%)
Query: 374 GSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGD 431
GS+ K +I L++G GLGF++ + H P IF+ I+P GAA DGRL D
Sbjct: 122 GSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE--------------------- 470
+L VN DV+ V L+ + G LV+ R++
Sbjct: 182 CVLRVNEVDVSEVVHSRAVEALK--EAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFS 239
Query: 471 ------GHFLP---------------RELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
+P + DGRL++ D+L+AVN +L + EA+ +L+
Sbjct: 240 IAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLK 299
Query: 510 RSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPL 569
N M+ L + + + D ++ P + + A+ + + NS L L
Sbjct: 300 -------NTSDMVYLKVAKPGSLHLND-----MYAPPDYASTFTALADNHISHNSSLGYL 347
Query: 570 GTCSPQDKQKGLLLPNDGWAESEVPP---SPTPHSAL 603
G + A +VPP SP P L
Sbjct: 348 GAVESKVSYP---------APPQVPPTRYSPIPRHML 375
Score = 52.0 bits (123), Expect = 3e-06
Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
KI L KG GLGF +V + G G IFV IL G A G L+ GDRIL VNG ++
Sbjct: 386 KIILHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 443 GRTQEELVAMLRSTKQGET 461
T E+ A L+ Q T
Sbjct: 442 NATHEQAAAALKRAGQSVT 460
Score = 38.9 bits (89), Expect = 0.028
Identities = 70/315 (22%), Positives = 123/315 (39%), Gaps = 51/315 (16%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL- 288
G+FI I + +G N+C++++N VD+ + ++A + ++A P V L V
Sbjct: 159 GIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVVRR 216
Query: 289 ---PPQ-----NREQYEKSV-------IGSLNIFGNNDGVLKTKVPPPVHGKSG------ 327
PP+ N + K + IG+ +I G+N + + K G
Sbjct: 217 RQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD 276
Query: 328 --LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKID 385
L N D +A ASL+ N S V KP S L+ + D
Sbjct: 277 RLLAVNNTNLQDVRHEEAVASLK-NTSDMVYLKVAKPGSLHLNDMYA----------PPD 325
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
L ++ +SS+ G + K P + R R + D T R
Sbjct: 326 YASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAE-EDFT-RE 383
Query: 446 QEELVAMLRSTKQGETASLVIARQEGHFL---------PRELDGRLRMNDQLIAVNGESL 496
+++ ST G ++ ++G + P +L G LR D++++VNG +L
Sbjct: 384 PRKIILHKGSTGLGFN---IVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
Query: 497 LGKSNHEAMETLRRS 511
++ +A L+R+
Sbjct: 441 RNATHEQAAAALKRA 455
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 62.4 bits (150), Expect = 2e-09
Identities = 108/483 (22%), Positives = 193/483 (39%), Gaps = 77/483 (15%)
Query: 370 LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
++G N+N ++L++GP G GF++ R + G +F+ + G AIKDGR+
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSL--RGGKEYNMG-LFILRLAEDGPAIKDGRIHV 1064
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRL-RMNDQL 488
GD+I+E+NG G T + ++++ G L++ R +P D + +
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQA---GGNKVLLLLRPGTGLIPDHGDWDINNPSSSN 1121
Query: 489 IAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCF 548
+ + +S L S+H A + + I +++ I + E + E
Sbjct: 1122 VIYDEQSPLPPSSHFASIFEESHVPV---IEESLRVQICEKAEELKDIVPE--------- 1169
Query: 549 ENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLE 608
S N+N P+ K + LL N PPS HS
Sbjct: 1170 -------KKSTLNEN---------QPEIKHQSLLQKN---VSKRDPPSSHGHS------- 1203
Query: 609 DYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSES 668
+ + V++ V RSV+P ++P S + + + +D +P K + + +S
Sbjct: 1204 NKKNLLKVENGV-----TRRGRSVSP-KKPASQH--SEEHLDKIPSPLKNNPKRRPRDQS 1255
Query: 669 PSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYD 728
S G + S+ S Q + RK+ RGR + + I+ S
Sbjct: 1256 LSPSKGENKSCQVSTRAGSGQD---QCRKS------------RGRSASPKKQQKIEGS-K 1299
Query: 729 GPEEIEADGLSDKSSH-SGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKL 787
P EA L KS +G N E P G + + + A++ + K + + EK
Sbjct: 1300 APSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIK 1359
Query: 788 KVKEKK--RKEENEDPERKIKKKGFGAMLRFGK--KKEDKGGKAEQKGTLKHGGLREEEL 843
++ EK K N+ +++ + G + G+ DK G+ Q L L++E
Sbjct: 1360 RMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQ---LSEKRLKQEPE 1416
Query: 844 EKM 846
EK+
Sbjct: 1417 EKV 1419
Score = 54.7 bits (130), Expect = 5e-07
Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 6/116 (5%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
++ LKK G GFT++ D + VKN+L G A +DG++ GD I+++NG V
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465
Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL-DGRLRMNDQLIAVNGESL 496
G T ++V M + + +L + R G+ LP + D + + +NG+SL
Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLPDDSEDPVVDIVAATPVINGQSL 519
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/158 (28%), Positives = 76/158 (48%), Gaps = 21/158 (13%)
Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377
S KTA + TD E + SL+ P + PS SP L P + +K
Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715
Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431
N K + + L+K G GF V+ D GP I++ I+P GAA KDGRL++ D
Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
++ ++G V G++ ++++ ++ + + L + R+
Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Score = 43.5 bits (101), Expect = 0.001
Identities = 37/144 (25%), Positives = 67/144 (46%), Gaps = 16/144 (11%)
Query: 335 GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
G PE D+S + QN SPR+ R P+ P+ + + + K+ EG
Sbjct: 813 GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861
Query: 393 LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
GF ++T ++ G P + ++ A + G+L+ GD I VNG+ + + + +V
Sbjct: 862 FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921
Query: 452 MLRSTKQGETASLVIARQEGHFLP 475
+++ G T +L + +E H P
Sbjct: 922 LIKDA--GVTVTLTVIAEEEHHGP 943
Score = 36.6 bits (83), Expect = 0.14
Identities = 41/187 (21%), Positives = 80/187 (42%), Gaps = 21/187 (11%)
Query: 358 LGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGF--TVVTRDSSIHGPGPIFVKNI 415
L G P SP+ + M +NA ++ + P+ + F +++ S P +++K+
Sbjct: 653 LRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKS- 711
Query: 416 LPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
+ D+ DV R QE G S+ I G +P
Sbjct: 712 ----------KTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYI----GAIIP 757
Query: 476 ---RELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER 532
E DGRLR D+L+ ++G + GKS+ + ++ L + + G++ ++ I ++
Sbjct: 758 LGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGHVLLTVRRKIFYGEKQ 816
Query: 533 PMEDPAE 539
P +D ++
Sbjct: 817 PEDDSSQ 823
Score = 33.1 bits (74), Expect = 1.5
Identities = 38/152 (25%), Positives = 56/152 (36%), Gaps = 12/152 (7%)
Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376
P ++G+S K + A Q KS L G + M +
Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571
Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
+ + I L KGP+G GF + P VK IL LQ GD I E+
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIA------DSPTGQKVKMILDSQWC---QGLQKGDIIKEI 622
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
++V T ++V +L+ G L+I R
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILR 654
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 61.6 bits (148), Expect = 4e-09
Identities = 36/79 (45%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 438 GRDVTGRTQEELVAMLRST 456
+ E+ VA L++T
Sbjct: 260 SVGLEDVMHEDAVAALKNT 278
Score = 50.4 bits (119), Expect = 9e-06
Identities = 34/90 (37%), Positives = 49/90 (54%), Gaps = 4/90 (4%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQE 470
V T V L+ + G L + R++
Sbjct: 168 VREVTHSAAVEALK--EAGSIVRLYVMRRK 195
Score = 48.5 bits (114), Expect = 4e-05
Identities = 102/441 (23%), Positives = 161/441 (36%), Gaps = 79/441 (17%)
Query: 58 ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFK- 116
+LD D + + K E+ PL SP+ P SP + ++
Sbjct: 38 LLDILDYYEASLSESQKYRYQDEDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYEL 95
Query: 117 ---PIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASH----PGG---QSLKLV 166
GE+E L+ G L + P PS PGG Q +L
Sbjct: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
Query: 167 VPDS---TQNLEDREVLNGVQTELLTSPRTKDTLSDMTR------TVEISGEGGPLGIHV 217
V DS ++ REV + E L + L M R +EI GP G+
Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG- 214
Query: 218 VPFFSSLSG----RILG---LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
FS G I G +++ I + + ++G + I+ +N+V L D A
Sbjct: 215 ---FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV------HG 324
+ V L V P N + + PP + H
Sbjct: 272 VAALKNTYDV--VYLKVAKPSNAYLSD------------------SYAPPDITTSYSQHL 311
Query: 325 KSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI 384
+ + ++ GTD P T + + + SP L G+ P + +I
Sbjct: 312 DNEISHSSYLGTDYP-TAMTPTSPRRYSPVAKDLLGEEDIPR-------------EPRRI 357
Query: 385 DLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR 444
+ +G GLGF +V + G G IF+ IL G A G L+ GD+IL VNG D+
Sbjct: 358 VIHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413
Query: 445 TQEELVAMLRSTKQGETASLV 465
+ E+ L++ G+T +++
Sbjct: 414 SHEQAAIALKNA--GQTVTII 432
Score = 32.0 bits (71), Expect = 3.5
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
P +L G LR DQ+++VNG L S+ +A L+ +
Sbjct: 389 PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 61.6 bits (148), Expect = 4e-09
Identities = 36/79 (45%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 438 GRDVTGRTQEELVAMLRST 456
+ E+ VA L++T
Sbjct: 214 SVGLEDVMHEDAVAALKNT 232
Score = 50.4 bits (119), Expect = 9e-06
Identities = 34/90 (37%), Positives = 49/90 (54%), Gaps = 4/90 (4%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQE 470
V T V L+ + G L + R++
Sbjct: 122 VREVTHSAAVEALK--EAGSIVRLYVMRRK 149
Score = 49.7 bits (117), Expect = 2e-05
Identities = 99/416 (23%), Positives = 153/416 (36%), Gaps = 76/416 (18%)
Query: 80 EEQEPLHKIESPSGNPADRQSPDAF-ETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVR 138
E+ PL SP+ P SP T+ GE+E L+ G L
Sbjct: 17 EDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGF 74
Query: 139 RSSDPVPGPPADTQPSASH----PGG---QSLKLVVPDS---TQNLEDREVLNGVQTELL 188
+ P PS PGG Q +L V DS ++ REV + E L
Sbjct: 75 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 134
Query: 189 TSPRTKDTLSDMTR------TVEISGEGGPLGIHVVPFFSSLSG----RILG---LFIRG 235
+ L M R +EI GP G+ FS G I G +++
Sbjct: 135 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG----FSIAGGVGNQHIPGDNSIYVTK 190
Query: 236 IEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQ 295
I + + ++G + I+ +N+V L D A + V L V P N
Sbjct: 191 IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV--VYLKVAKPSNAYL 248
Query: 296 YEKSVIGSLNIFGNNDGVLKTKVPPPV------HGKSGLKTANLTGTDSPETDASASLQQ 349
+ + PP + H + + ++ GTD P T + + +
Sbjct: 249 SD------------------SYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAMTPTSPR 289
Query: 350 NKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP 409
SP L G+ P + +I + +G GLGF +V + G G
Sbjct: 290 RYSPVAKDLLGEEDIPR-------------EPRRIVIHRGSTGLGFNIVGGED---GEG- 332
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
IF+ IL G A G L+ GD+IL VNG D+ + E+ L++ G+T +++
Sbjct: 333 IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTII 386
Score = 32.7 bits (73), Expect = 2.0
Identities = 79/388 (20%), Positives = 140/388 (36%), Gaps = 51/388 (13%)
Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
PP + P+ H Q+ V +T LE +NG + E+ + TL +
Sbjct: 20 PPLEHSPA--HLPNQANSPPVIVNTDTLEAPGYVNGTEGEM---EYEEITLERGNSGLGF 74
Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
S GG H+ G +FI I + ++G N+ I+ +N VD+ + T
Sbjct: 75 SIAGGTDNPHI--------GDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
Query: 267 FAQAQDVFRQAMKSPSVLLHVL---PPQNREQYEKSV-------------IGSLNIFGNN 310
+ A + ++A V L+V+ PP + K + +G+ +I G+N
Sbjct: 127 HSAAVEALKEA--GSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDN 184
Query: 311 DGVLKTKVPPPVHGKSG-------LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS 363
+ + K G + N G + + + + +N V KPS
Sbjct: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPS 244
Query: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIK 423
+ LS + +D + ++ S + P + P+ +
Sbjct: 245 NAYLSDSYAPPDITTSYSQHLDNE----------ISHSSYLGTDYPTAMTPTSPRRYSPV 294
Query: 424 DGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRLR 483
L + I R V R L + + GE + G P +L G LR
Sbjct: 295 AKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGG---PADLSGELR 351
Query: 484 MNDQLIAVNGESLLGKSNHEAMETLRRS 511
DQ+++VNG L S+ +A L+ +
Sbjct: 352 KGDQILSVNGVDLRNASHEQAAIALKNA 379
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 61.2 bits (147), Expect = 5e-09
Identities = 36/110 (32%), Positives = 64/110 (58%), Gaps = 1/110 (0%)
Query: 757 QGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRF 816
Q SE + + K K+ +EKE+K+E+GK + K++K++E ++ ERK K++ R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER- 89
Query: 817 GKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
+K+ K K ++K K G RE + +K ++ERER + +E + K+ R
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Score = 53.9 bits (128), Expect = 8e-07
Identities = 34/108 (31%), Positives = 60/108 (55%), Gaps = 8/108 (7%)
Query: 763 EDMENKARKVKKTKEKEKKKEKGKLKVKEKK----RKEENEDPERKIKKKGFGAMLRFGK 818
E E + RK KK K+K ++K++G+ + K+KK R+ EN+ + +KK R +
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 819 KKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
K+E + GK E+K + ++EE EK +E + K +E +E++ R
Sbjct: 148 KREKERGKRERKRKKR----KKEEREKKRERNRKERKKERERKERRER 191
Score = 48.5 bits (114), Expect = 4e-05
Identities = 32/99 (32%), Positives = 57/99 (57%), Gaps = 2/99 (2%)
Query: 768 KARKVKKTKEKEK-KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGK 826
K RK ++ KE+ K KKEK K + K++ R+E + ERK +++ +KK K +
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 827 AEQKGTLKHGGLREEELEK-MKEERERIGAKHQELREKQ 864
+++ K G RE + +K KEERE+ ++++ R+K+
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKE 182
Score = 48.5 bits (114), Expect = 4e-05
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 6/110 (5%)
Query: 753 ESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGA 812
E + E K RK K+ KE++++KE+GK + K KKRK+E + +R+ +K
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK---- 177
Query: 813 MLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELRE 862
K++E K + +K K ++E + K +R+ + LRE
Sbjct: 178 --ERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRE 225
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/104 (27%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 763 EDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKED 822
++ E K ++ +K +++ ++KE+ K K ++KKR+ + + KKK R K++ +
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 823 KGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
+ K +K K R+ E E+ K ER+R K +E +K+ R
Sbjct: 133 RKRKKRRK--KKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/101 (30%), Positives = 57/101 (56%), Gaps = 8/101 (7%)
Query: 766 ENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGG 825
E K +K +K +E+E K+ + + + K +K+K E ++ K++G R +KKE++
Sbjct: 113 ERKKKKERKERERENKQRRERKRKKRRKKKRRKE--RKREKERGKRERKRKKRKKEEREK 170
Query: 826 KAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
K E ++ R++E E+ KE RER + +E R+K+ R
Sbjct: 171 KRE-----RNRKERKKERER-KERRERKKERKKERRKKKER 205
Score = 30.8 bits (68), Expect = 7.7
Identities = 21/83 (25%), Positives = 44/83 (53%), Gaps = 10/83 (12%)
Query: 790 KEKKRKEENEDPER-----KIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELE 844
+ +++KE E +R K +K+ G + +KK ++G + E+K RE++ +
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRK-----EREKQRK 87
Query: 845 KMKEERERIGAKHQELREKQARG 867
+ +E+ R K ++ RE++ RG
Sbjct: 88 ERREKERRKRKKEKKKRERKQRG 110
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 61.2 bits (147), Expect = 5e-09
Identities = 80/317 (25%), Positives = 138/317 (43%), Gaps = 41/317 (12%)
Query: 203 TVEISGEGGPLGIHVV---PFFSSLSGRIL-GLFIRGIEDNSRSKREGLFHENECIVKIN 258
T+ + + G LG +++ P + G G+F+ I D+ + +EG ++ I+++N
Sbjct: 249 TLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
Query: 259 NVDLVDKTFAQAQDVFRQAMKSPSVL--------LHVLPPQNREQYEKSVIGSLNIFGNN 310
DL T QA + F+ A K P V+ + P + Q + + F +
Sbjct: 309 GRDLSRATHDQAVEAFKTA-KEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHI 367
Query: 311 DGVLKTKVP-PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSP 369
+ K P PPV L PE SA + + + + + L
Sbjct: 368 MALTKMSSPSPPVLDPYLL----------PEEHPSAHEYYDPNDYIGDIHQEMDREELE- 416
Query: 370 LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
+++ + + LG TV R G I++ I P A KDGR++
Sbjct: 417 ---------LEEVDLYRMNSQDKLGLTVCYRTDDEDDIG-IYISEIDPNSIAAKDGRIRE 466
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLI 489
GDRI+++NG +V R EE VA+L S ++ + SL+IAR E +D ND L
Sbjct: 467 GDRIIQINGIEVQNR--EEAVALLTS-EENKNFSLLIARPELQLDEGWMDD--DRNDFLD 521
Query: 490 AVNGESLLGKSNHEAME 506
++ + +L + +H+AM+
Sbjct: 522 DLHMD-MLEEQHHQAMQ 537
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 374 GSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-----IFVKNILPKGAAIKDGRLQ 428
G + K + + L + LGF ++ S+ IFV I+ G A K+G LQ
Sbjct: 240 GKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQ 299
Query: 429 SGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458
DRI+EVNGRD++ T ++ V ++ K+
Sbjct: 300 IHDRIIEVNGRDLSRATHDQAVEAFKTAKE 329
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 60.8 bits (146), Expect = 7e-09
Identities = 30/73 (41%), Positives = 43/73 (58%)
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
K+ +GLGF++ I G IFVK I P G+A +DGRL+ GD IL+VNG + G T
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 447 EELVAMLRSTKQG 459
+E + + + G
Sbjct: 651 QEAIHTFKQIRSG 663
Score = 57.4 bits (137), Expect = 8e-08
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397
P+TDA + +K R GGK S L + + +I K++L K +GLG V
Sbjct: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348
Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
S P I V + GAA +DGRL GD +L +NG + G + EE VA+LRS
Sbjct: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408
Query: 458 QGETASLVIARQE 470
LV+A +E
Sbjct: 409 --GMVQLVVASKE 419
Score = 50.4 bits (119), Expect = 9e-06
Identities = 24/82 (29%), Positives = 46/82 (56%)
Query: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
+++ K GLG ++ SS+ G GP+ +K + GAA + G +++GD IL +NG+ + G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
Query: 444 RTQEELVAMLRSTKQGETASLV 465
+ +++S +G L+
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832
Score = 44.7 bits (104), Expect = 5e-04
Identities = 59/265 (22%), Positives = 102/265 (38%), Gaps = 50/265 (18%)
Query: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
+G LG + + G+ +G+F++ I N + +G E + I+ +N + + TF
Sbjct: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
Query: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
+A F+Q VL ++TK+ P
Sbjct: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683
Query: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
T +++ + SP T AS + LG K P K+ +++ L
Sbjct: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731
Query: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
K P G+G + ++S P I++ ++ P A + L GD+ILEVN +V
Sbjct: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
Query: 444 RTQEELVAMLRSTKQGETASLVIAR 468
++ A+L G LVI R
Sbjct: 789 AALSKVHAILSKCPPG-PVRLVIGR 812
Score = 43.9 bits (102), Expect = 9e-04
Identities = 34/110 (30%), Positives = 55/110 (50%), Gaps = 10/110 (9%)
Query: 454 RSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMS 513
R +K+ A +V +EG R DGRL + D+L+ +NG L+G S+ EA+ LR
Sbjct: 352 RGSKRSPHAIVVTQVKEGGAAHR--DGRLSLGDELLVINGHLLVGLSHEEAVAILR---- 405
Query: 514 MEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 563
+ GM+QLV+ + E ED + S P + V++ N++
Sbjct: 406 ---SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
Score = 39.7 bits (91), Expect = 0.017
Identities = 33/128 (25%), Positives = 58/128 (45%), Gaps = 9/128 (7%)
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
+K GLGF+V + P I V + +GAA ++G + GD +L VNG + G
Sbjct: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
Query: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAME 506
++ +L + + A +VI ++G PR + NG+ LL +
Sbjct: 2685 GNVLKVLHQAQLHKDALVVI--KKGMDQPRP-----SARQEPPTANGKGLLSRKTIPLEP 2737
Query: 507 TLRRSMSM 514
+ RS+++
Sbjct: 2738 GIGRSVAV 2745
Score = 32.3 bits (72), Expect = 2.6
Identities = 30/128 (23%), Positives = 53/128 (41%), Gaps = 13/128 (10%)
Query: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
DGRL+ D+++ VNG + G + EA+ T ++ S G ++ ++ P P
Sbjct: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRS--GLFVLTVRTKLVSPSLTPCSTPT 685
Query: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598
+ P F A ++ +D LG +P K + ++ EV +
Sbjct: 686 HMSRSASPNFNTSGGA--SAGGSDEGSSSSLGRKTPGPKDRIVM---------EVTLNKE 734
Query: 599 PHSALGLG 606
P LG+G
Sbjct: 735 PRVGLGIG 742
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 60.5 bits (145), Expect = 9e-09
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 7/146 (4%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1112 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1166
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1167 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1226
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQ 458
+L VNG + G T ++ V LR+T Q
Sbjct: 1227 VLAVNGVSLEGATHKQAVETLRNTGQ 1252
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/282 (21%), Positives = 113/282 (40%), Gaps = 53/282 (18%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1178 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1236
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1237 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1273
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1274 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1312
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1313 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRL 482
+ G +Q+E+++ LR T L++ R LP E+D L
Sbjct: 1371 LKGLSQQEVISALRGT--APEVFLLLCRPPPGVLP-EIDTAL 1409
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 8/89 (8%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1649
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIAR 468
DVT T + V +LR+ +T LVI R
Sbjct: 1650 DVTNMTHTDAVNLLRAA--SKTVRLVIGR 1676
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 963 GVSHHAAIEILQNAP--EDVTLVISQ 986
Score = 40.0 bits (92), Expect = 0.013
Identities = 84/404 (20%), Positives = 147/404 (36%), Gaps = 77/404 (19%)
Query: 163 LKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFS 222
L++ S Q+ +D +VL+ + +++SP + TL ++ + + LG ++
Sbjct: 869 LQMRARQSNQDAQDIDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--G 920
Query: 223 SLSGRI-LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA---- 277
GR+ LG+FI + + +G + ++ +N+V L + A ++ + A
Sbjct: 921 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 980
Query: 278 -----------MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPP 320
K PS +H+ + S + I ++ G L+
Sbjct: 981 TLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1040
Query: 321 PVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLG---------GKPSSPSLSPLM 371
GL+ +L+ DS AS S Q LG G PS +S
Sbjct: 1041 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1100
Query: 372 G---FGSNKNAKKIKIDLK-------KGPEGLGFTVVTRD-----------SSIHGPGPI 410
F + +K K + +G + + SS++ +
Sbjct: 1101 EKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKM 1160
Query: 411 FVKNIL---PKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIA 467
K PK I + L D L G VTG S + G +
Sbjct: 1161 NFKTFSSSPPKPGDIFEVELAKNDNSL---GISVTGGVNT-------SVRHGGIYVKAVI 1210
Query: 468 RQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
Q E DGR+ D+++AVNG SL G ++ +A+ETLR +
Sbjct: 1211 PQGA----AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT 1250
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1699
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1700 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754
Query: 448 EL 449
E+
Sbjct: 1755 EV 1756
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 60.5 bits (145), Expect = 9e-09
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 7/146 (4%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1303 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1357
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQ 458
+L VNG + G T ++ V LR+T Q
Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNTGQ 1443
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/282 (21%), Positives = 113/282 (40%), Gaps = 53/282 (18%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1369 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1427
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1428 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1464
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1465 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1503
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1504 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRL 482
+ G +Q+E+++ LR T L++ R LP E+D L
Sbjct: 1562 LKGLSQQEVISALRGT--APEVFLLLCRPPPGVLP-EIDTAL 1600
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 8/89 (8%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1840
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIAR 468
DVT T + V +LR+ +T LVI R
Sbjct: 1841 DVTNMTHTDAVNLLRAA--SKTVRLVIGR 1867
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 1154 GVSHHAAIEILQNAP--EDVTLVISQ 1177
Score = 38.5 bits (88), Expect = 0.037
Identities = 49/176 (27%), Positives = 74/176 (42%), Gaps = 23/176 (13%)
Query: 355 VPRLGGKPSSP----SLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI 410
V L GKPS L G N+K + L + PE + SSI PG
Sbjct: 996 VAELVGKPSHQMSRSDAESLAGVTKLNNSKSVA-SLNRSPERRKHE--SDSSSIEDPGQA 1052
Query: 411 FVKNIL--PKGAAIKDGRLQSGDRILEVNGRDVTGRTQE-ELVAMLRSTKQGETASLVIA 467
+V + G + L+ D +L V+ +E LV + + K G ++
Sbjct: 1053 YVLGMTMHSSGNSSSQVPLKEND-VLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111
Query: 468 RQEGH-----FL-------PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+ G F+ P +LDG L+ D+LI+VN SL G S+H A+E L+ +
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1167
Score = 38.1 bits (87), Expect = 0.048
Identities = 17/35 (48%), Positives = 26/35 (74%)
Query: 477 ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
E DGR+ D+++AVNG SL G ++ +A+ETLR +
Sbjct: 1407 ESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT 1441
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1890
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1891 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945
Query: 448 EL 449
E+
Sbjct: 1946 EV 1947
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 60.5 bits (145), Expect = 9e-09
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 7/146 (4%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1284 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1338
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1339 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1398
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQ 458
+L VNG + G T ++ V LR+T Q
Sbjct: 1399 VLAVNGVSLEGATHKQAVETLRNTGQ 1424
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/282 (21%), Positives = 113/282 (40%), Gaps = 53/282 (18%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1350 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1409 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1445
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1446 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1484
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1485 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRL 482
+ G +Q+E+++ LR T L++ R LP E+D L
Sbjct: 1543 LKGLSQQEVISALRGT--APEVFLLLCRPPPGVLP-EIDTAL 1581
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 8/89 (8%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1821
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIAR 468
DVT T + V +LR+ +T LVI R
Sbjct: 1822 DVTNMTHTDAVNLLRAA--SKTVRLVIGR 1848
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 1135 GVSHHAAIEILQNAP--EDVTLVISQ 1158
Score = 40.8 bits (94), Expect = 0.007
Identities = 50/175 (28%), Positives = 72/175 (41%), Gaps = 40/175 (22%)
Query: 355 VPRLGGKPSSP----SLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI 410
V L GKPS L G N+K + L + PE + SSI PG
Sbjct: 996 VAELVGKPSHQMSRSDAESLAGVTKLNNSKSVA-SLNRSPERRKHE--SDSSSIEDPGQA 1052
Query: 411 FVKNILPKGAAI--------------KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRST 456
+V ++L K +I KD + G +I+ G + GR +L + S
Sbjct: 1053 YVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQII---GGEKMGRL--DLGIFISSV 1107
Query: 457 KQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
G P +LDG L+ D+LI+VN SL G S+H A+E L+ +
Sbjct: 1108 APGG--------------PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1148
Score = 38.1 bits (87), Expect = 0.048
Identities = 17/35 (48%), Positives = 26/35 (74%)
Query: 477 ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
E DGR+ D+++AVNG SL G ++ +A+ETLR +
Sbjct: 1388 ESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT 1422
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1871
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1872 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926
Query: 448 EL 449
E+
Sbjct: 1927 EV 1928
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 60.1 bits (144), Expect = 1e-08
Identities = 35/79 (44%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 438 GRDVTGRTQEELVAMLRST 456
+ T EE V L++T
Sbjct: 376 NVCLEEVTHEEAVTALKNT 394
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)
Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
LK P ++ G ++T + S D S LG P+SP+ SP+
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452
Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
GDRI+ VN D+ + E+ A L++ Q T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Score = 51.2 bits (121), Expect = 5e-06
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 50/207 (24%)
Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249
Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ + G L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK--EAGSIVRLYV 307
Query: 467 ARQE---------------------------GHFLPRE---------------LDGRLRM 484
R++ +P + DG+L++
Sbjct: 308 KRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367
Query: 485 NDQLIAVNGESLLGKSNHEAMETLRRS 511
D+L+AVN L ++ EA+ L+ +
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNT 394
Score = 38.5 bits (88), Expect = 0.037
Identities = 75/378 (19%), Positives = 131/378 (34%), Gaps = 47/378 (12%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPP 290
+FI I + ++G N+CI+++N VD+ D T ++A + ++A + + P
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Query: 291 QNREQYEKSVI--------------GSLNIFGNNDGVLKTKVPPPVHGKSG-------LK 329
+ + E +I G+ +I G+N + + K G L
Sbjct: 313 VSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 330 TANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKG 389
N + + + + +N S V KP+S ++ N+ +D
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVS 432
Query: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
P SS G P P A+ D I + V R L
Sbjct: 433 P-----------SSFLGQTPASPARYSPVSKAV-----LGDDEITREPRKVVLHRGSTGL 476
Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
+ + GE + G P +L G LR D++I+VN L S+ +A L+
Sbjct: 477 GFNIVGGEDGEGIFISFILAGG---PADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Query: 510 RSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPL 569
N + +V RPE A+ + + ++ + S R +
Sbjct: 534 -------NAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYV 586
Query: 570 GTCSPQDKQKGLLLPNDG 587
DK K LP+ G
Sbjct: 587 RALFDYDKTKDSGLPSQG 604
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 60.1 bits (144), Expect = 1e-08
Identities = 35/79 (44%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 438 GRDVTGRTQEELVAMLRST 456
+ T EE V L++T
Sbjct: 376 NVCLEEVTHEEAVTALKNT 394
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)
Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
LK P ++ G ++T + S D S LG P+SP+ SP+
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452
Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
GDRI+ VN D+ + E+ A L++ Q T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Score = 51.2 bits (121), Expect = 5e-06
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 50/207 (24%)
Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249
Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ + G L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK--EAGSIVRLYV 307
Query: 467 ARQE---------------------------GHFLPRE---------------LDGRLRM 484
R++ +P + DG+L++
Sbjct: 308 KRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367
Query: 485 NDQLIAVNGESLLGKSNHEAMETLRRS 511
D+L+AVN L ++ EA+ L+ +
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNT 394
Score = 40.4 bits (93), Expect = 0.010
Identities = 94/478 (19%), Positives = 165/478 (34%), Gaps = 70/478 (14%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPP 290
+FI I + ++G N+CI+++N VD+ D T ++A + ++A + + P
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Query: 291 QNREQYEKSVI--------------GSLNIFGNNDGVLKTKVPPPVHGKSG-------LK 329
+ + E +I G+ +I G+N + + K G L
Sbjct: 313 VSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 330 TANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKG 389
N + + + + +N S V KP+S ++ N+ +D
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVS 432
Query: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
P SS G P P A+ D I + V R L
Sbjct: 433 P-----------SSFLGQTPASPARYSPVSKAV-----LGDDEITREPRKVVLHRGSTGL 476
Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
+ + GE + G P +L G LR D++I+VN L S+ +A L+
Sbjct: 477 GFNIVGGEDGEGIFISFILAGG---PADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Query: 510 RSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPL 569
N + +V RPE A+ E N+ +S
Sbjct: 534 -------NAGQAVTIVAQYRPEEYSRFEAKIHDLR----EQMMNSSISS----------- 571
Query: 570 GTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINF 629
G+ S + QK L + + S P L D H D+
Sbjct: 572 GSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASD-----DEWWQA 626
Query: 630 RSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLES 687
R VTP + + + + SK + +++ ++ K S ++D G + K+ +L S
Sbjct: 627 RQVTPDGESDEVGVIPSKRRVEKKERARLKTV---KFNSKTRDKGQSFNDKRKKNLFS 681
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 60.1 bits (144), Expect = 1e-08
Identities = 31/75 (41%), Positives = 44/75 (58%), Gaps = 2/75 (2%)
Query: 383 KIDLKKGPEGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I+L +GP GLGF +V T + I+V I GAA DGRLQ GD+IL VNG+D
Sbjct: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
Query: 441 VTGRTQEELVAMLRS 455
+ ++ V + R+
Sbjct: 73 LKNLLHQDAVDLFRN 87
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 59.7 bits (143), Expect = 2e-08
Identities = 41/116 (35%), Positives = 64/116 (55%), Gaps = 8/116 (6%)
Query: 753 ESAPQGNSELEDMENKAR----KVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKK 808
E+ +G E E K R K K+ +EKE+K+E+GK + K +++KEE E +R+ +K+
Sbjct: 46 ETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKE 105
Query: 809 GFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQ 864
K+K K K E+ T K G RE + E+ +EER+ K +E REK+
Sbjct: 106 NKEGE---EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE-REKE 157
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/105 (30%), Positives = 60/105 (57%), Gaps = 25/105 (23%)
Query: 764 DMENKARKVKKTKEKEKKKEKGKL--KVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKE 821
+ ENK + K+ ++K++KKE+G+ + KE++RKEE + ERK ++ +KKE
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE----------RKKE 152
Query: 822 DKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
++ + E+K E+ K ER+++G K +E +EK+ +
Sbjct: 153 EREKERERK-------------ERKKRERKQVGEKEEERKEKERK 184
Score = 51.6 bits (122), Expect = 4e-06
Identities = 31/116 (26%), Positives = 65/116 (56%), Gaps = 11/116 (9%)
Query: 759 NSELEDMENKARKVKKT--------KEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGF 810
N E E+ E + +K KK KE+E+K+E+ + + KE++RK+E + ER+ K++
Sbjct: 106 NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK 165
Query: 811 GAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
+ G+K+E++ K ++ + +E + E+ ++ER + +E ++K+ R
Sbjct: 166 RERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRE---RKKERKKKEER 218
Score = 44.3 bits (103), Expect = 7e-04
Identities = 34/117 (29%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 756 PQGNSELEDMENKA---RKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPER---KIKKKG 809
P SE+ + E + ++ KK +E E+KKE+ + +EK+++E ++ +R K +KKG
Sbjct: 32 PGWQSEIREREREIETRKEGKKERESERKKER---REREKRKREREKERKRERGKKEKKG 88
Query: 810 FGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQAR 866
KK+E + K ++ K G +E+ +K K+ER R + +E K+ R
Sbjct: 89 ------ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEER 139
Score = 44.3 bits (103), Expect = 7e-04
Identities = 32/130 (24%), Positives = 62/130 (47%), Gaps = 7/130 (5%)
Query: 741 KSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKK----RKE 796
K +G + E + E E + + +K +E+EK++E+ + K +E+K ++E
Sbjct: 117 KKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEE 176
Query: 797 ENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAK 856
E ++ ERK +KK K++E K + +K K E + E+ K+ + K
Sbjct: 177 ERKEKERKERKKRERNRKERKKERERKERRERKKERKKK---EERKKERQKDRQTNWREK 233
Query: 857 HQELREKQAR 866
+ RE++ R
Sbjct: 234 ERGKRERKER 243
Score = 38.5 bits (88), Expect = 0.037
Identities = 27/104 (25%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 761 ELEDMENKARKVKKTKE-KEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKK 819
E ++ E K + +K +E KE+KK + K ++++ ++E E ERK +++ + ++
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER 202
Query: 820 KEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREK 863
KE + K E+K + R+++ + E+ER G + ++ R+K
Sbjct: 203 KERRERKKERKKKEERKKERQKDRQTNWREKER-GKRERKERKK 245
Score = 34.3 bits (77), Expect = 0.70
Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 21/142 (14%)
Query: 711 RGRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKAR 770
RGR E K + EE + + ++ + E + E + + K
Sbjct: 123 RGRTSKEG------KERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEE 176
Query: 771 KVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQK 830
+ K+ + KE+KK + K+RK+E E ER+ +KK +KK+++ K QK
Sbjct: 177 ERKEKERKERKKRER----NRKERKKERERKERRERKK--------ERKKKEERKKERQK 224
Query: 831 GTLKHGGLREEELEKMKEERER 852
+ RE+E K +E +ER
Sbjct: 225 D--RQTNWREKERGK-RERKER 243
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/82 (40%), Positives = 47/82 (57%), Gaps = 1/82 (1%)
Query: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
I +KK P E LG TV S G PIFV ++ P G +DGR++ GD +L +NG D+T
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
Query: 443 GRTQEELVAMLRSTKQGETASL 464
+ E VAML+++ +L
Sbjct: 529 NLSHSEAVAMLKASAASPAVAL 550
Score = 55.5 bits (132), Expect = 3e-07
Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%)
Query: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272
LG+ V S SG L +F+ + + R+G + ++ IN +DL + + ++A
Sbjct: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
Query: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332
+ + + SP+V L L Q E+ ++ + F N
Sbjct: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575
Query: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
E DAS S PS +G S ++ + +
Sbjct: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610
Query: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452
GF++V H P F+K I+ A DGRL+ GD I+ VNG G + LV M
Sbjct: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670
Query: 453 LRSTKQGETASLV 465
L+ + T +++
Sbjct: 671 LKEQRNKVTLTVI 683
Score = 48.5 bits (114), Expect = 4e-05
Identities = 30/88 (34%), Positives = 49/88 (55%), Gaps = 6/88 (6%)
Query: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
++ + + E LG +V R PG +F+ ++L G A +DGRL S DR+L +NG D
Sbjct: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIAR 468
+ T E +++++ GE +L IAR
Sbjct: 395 LKYGTPELAAQIIQAS--GERVNLTIAR 420
Score = 31.6 bits (70), Expect = 4.5
Identities = 17/60 (28%), Positives = 33/60 (55%), Gaps = 2/60 (3%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I ++ + G +DGRL +GD+IL+VN +++ + A+L ++ T L + R+
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317
Score = 31.2 bits (69), Expect = 5.9
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
VA R +K GE V + L R DGR++ D L+ +NG L S+ EA+ L+
Sbjct: 483 VAGGRGSKSGELPIFVTSVPPHGCLAR--DGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
Query: 510 RS 511
S
Sbjct: 541 AS 542
Score = 31.2 bits (69), Expect = 5.9
Identities = 14/35 (40%), Positives = 21/35 (60%)
Query: 475 PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 509
P DGRL+ D ++AVNG S +G S+ + L+
Sbjct: 638 PAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 672
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 57.4 bits (137), Expect = 8e-08
Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 8/121 (6%)
Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV 397
+P+ ++S+S+ + P P + N N+ I + + G+ +V
Sbjct: 1336 TPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSV 1395
Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
G I+VK ++P+GAA DGR+ GDR+L VNG + G T ++ V LR+T
Sbjct: 1396 --------RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG 1447
Query: 458 Q 458
Q
Sbjct: 1448 Q 1448
Score = 57.0 bits (136), Expect = 1e-07
Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 56/286 (19%)
Query: 204 VEISGEGGPLGIHVVPFFS----SLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINN 259
VE++ LGI V F + S R G++++ + ++ +G H+ + ++ +N
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428
Query: 260 VDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVP 319
V L T QA + R + ++H+L + + K +
Sbjct: 1429 VSLEGATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV------------------ 1466
Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA 379
PV + L N G + + ++ F + +N
Sbjct: 1467 -PVTPQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENT 1504
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
++K L K GLGF+ D+ I + VK + P A + G++ GD IL+V
Sbjct: 1505 FEVK--LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1562
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDGRL 482
NG + G +Q+E+++ LR T L++ R LP E+D L
Sbjct: 1563 NGASLKGLSQQEVISALRGT--APEVFLLLCRPPPGVLP-EIDTAL 1605
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 8/89 (8%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1845
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIAR 468
DVT T + V +LR+ +T LVI R
Sbjct: 1846 DVTNMTHTDAVNLLRAA--SKTVRLVIGR 1872
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 1154 GVSHHAAIEILQNAP--EDVTLVISQ 1177
Score = 38.5 bits (88), Expect = 0.037
Identities = 49/176 (27%), Positives = 74/176 (42%), Gaps = 23/176 (13%)
Query: 355 VPRLGGKPSSP----SLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI 410
V L GKPS L G N+K + L + PE + SSI PG
Sbjct: 996 VAELVGKPSHQMSRSDAESLAGVTKLNNSKSVA-SLNRSPERRKHE--SDSSSIEDPGQA 1052
Query: 411 FVKNIL--PKGAAIKDGRLQSGDRILEVNGRDVTGRTQE-ELVAMLRSTKQGETASLVIA 467
+V + G + L+ D +L V+ +E LV + + K G ++
Sbjct: 1053 YVLGMTMHSSGNSSSQVPLKEND-VLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111
Query: 468 RQEGH-----FL-------PRELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
+ G F+ P +LDG L+ D+LI+VN SL G S+H A+E L+ +
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1167
Score = 38.1 bits (87), Expect = 0.048
Identities = 17/35 (48%), Positives = 26/35 (74%)
Query: 477 ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
E DGR+ D+++AVNG SL G ++ +A+ETLR +
Sbjct: 1412 ESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT 1446
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1895
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1896 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950
Query: 448 EL 449
E+
Sbjct: 1951 EV 1952
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 56.2 bits (134), Expect = 2e-07
Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 41/274 (14%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
G+FI I +++ I+ +N++ L TF A R SP
Sbjct: 780 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 828
Query: 290 PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349
+ E + S + GNN K SG+ + ++ + S + Q
Sbjct: 829 ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 879
Query: 350 NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394
+++ + G S S PL G GS+ +I +L K LG
Sbjct: 880 DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 939
Query: 395 FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
F+V ++ G I+VK+I+P G A K+G++ GDR+L+V+G + G T ++ V L
Sbjct: 940 FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 998
Query: 455 STKQGETASLVIARQEGHFLPRELDGRLRMNDQL 488
T G+ A LV+ R+ +PR ND +
Sbjct: 999 -TGPGQVARLVLERR----VPRSTQQCPSANDSM 1027
Score = 51.6 bits (122), Expect = 4e-06
Identities = 65/275 (23%), Positives = 109/275 (39%), Gaps = 56/275 (20%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE+ E G LG V ++ S G++++ I + +EG + + +++++ V L
Sbjct: 929 VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 987
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA Q + P + + VL+ +VP
Sbjct: 988 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1018
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
P + S ++ V L G+PSS S + K +
Sbjct: 1019 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1057
Query: 384 IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+ LKK GLGF+ V ++S H + +K + P A ++G + +GD IL VNGR
Sbjct: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
G +E++ +LR Q T L++ R LP
Sbjct: 1118 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP 1150
Score = 40.8 bits (94), Expect = 0.007
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%)
Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
M GS N +K +++ LK+ P G GF + + S IF+ +I+P G
Sbjct: 731 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 790
Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
A K ++ G +IL +N + G T V M++++ + L+I++ +G
Sbjct: 791 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 840
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,756,159
Number of Sequences: 37866
Number of extensions: 3181494
Number of successful extensions: 24525
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 378
Number of HSP's successfully gapped in prelim test: 802
Number of HSP's that attempted gapping in prelim test: 14332
Number of HSP's gapped (non-prelim): 6614
length of query: 1143
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1030
effective length of database: 13,968,660
effective search space: 14387719800
effective search space used: 14387719800
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.