Search of human proteins with 239752702

Search of human proteins with 239752702

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239752702 PREDICTED: leucine rich repeat containing 38,
partial [Homo sapiens]
         (254 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...   503   e-143
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ...   493   e-140
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ...   493   e-140
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          160   8e-40
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          123   1e-28
gi|194018474 leucine rich repeat containing 52 [Homo sapiens]         120   1e-27
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   105   4e-23
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                105   4e-23
gi|4759146 slit homolog 2 [Homo sapiens]                               99   5e-21
gi|188528675 slit homolog 1 [Homo sapiens]                             99   5e-21
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    97   1e-20
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    96   3e-20
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    96   3e-20
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    95   5e-20
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              95   7e-20
gi|11321571 slit homolog 3 [Homo sapiens]                              94   9e-20
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          90   2e-18
gi|198041768 synleurin [Homo sapiens]                                  87   1e-17
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       87   1e-17
gi|40217825 slit and trk like 6 [Homo sapiens]                         87   2e-17
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    86   3e-17
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    86   3e-17
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    86   3e-17
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    86   3e-17
gi|116268101 leucine rich repeat containing 62 [Homo sapiens]          86   4e-17
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 82   6e-16
gi|225579152 insulin-like growth factor binding protein, acid la...    81   1e-15
gi|4826772 insulin-like growth factor binding protein, acid labi...    81   1e-15
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...    80   1e-15
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...    80   1e-15

>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score =  503 bits (1296), Expect = e-143
 Identities = 254/254 (100%), Positives = 254/254 (100%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF
Sbjct: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN
Sbjct: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP
Sbjct: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180

Query: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCA 240
           MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCA
Sbjct: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCA 240

Query: 241 PNKDAEDEDEDKDD 254
           PNKDAEDEDEDKDD
Sbjct: 241 PNKDAEDEDEDKDD 254


>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  493 bits (1270), Expect = e-140
 Identities = 250/250 (100%), Positives = 250/250 (100%)

Query: 5   RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 64
           RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA
Sbjct: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218

Query: 65  KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 124
           KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL
Sbjct: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278

Query: 125 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 184
           RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR
Sbjct: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338

Query: 185 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 244
           RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD
Sbjct: 339 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 398

Query: 245 AEDEDEDKDD 254
           AEDEDEDKDD
Sbjct: 399 AEDEDEDKDD 408


>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  493 bits (1270), Expect = e-140
 Identities = 250/250 (100%), Positives = 250/250 (100%)

Query: 5   RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 64
           RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA
Sbjct: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218

Query: 65  KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 124
           KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL
Sbjct: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278

Query: 125 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 184
           RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR
Sbjct: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338

Query: 185 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 244
           RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD
Sbjct: 339 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 398

Query: 245 AEDEDEDKDD 254
           AEDEDEDKDD
Sbjct: 399 AEDEDEDKDD 408


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  160 bits (406), Expect = 8e-40
 Identities = 91/248 (36%), Positives = 128/248 (51%), Gaps = 1/248 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  + L SVP   P+D R L +A NRI  +P  +   Y +L  LD  NNSL  L  G F
Sbjct: 93  DCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLF 152

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNN-LVGVHEDAFETLESLQVLEL 119
             + +L  LDLSYNN + + A  F+ A  LV + L++N  L  VH  AF+ L  L+ L+L
Sbjct: 153 LHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDL 212

Query: 120 NDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSL 179
           +   L  LS+ AL  LP L +L++ GNPW+C C    L  W++    +        +C  
Sbjct: 213 SYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRG 272

Query: 180 PMESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRC 239
           P E     L  L+E SF  C  +L+L D   I F G  VSIA++ ++F L     C  R 
Sbjct: 273 PPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRW 332

Query: 240 APNKDAED 247
           +   + E+
Sbjct: 333 SKASEEEE 340


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  123 bits (309), Expect = 1e-28
 Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 3/231 (1%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C    LP+VP    L +R LL+  NR++ +P   F   G L  LD R N L S+    F 
Sbjct: 57  CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
           G   L  LDLS N L  L  G F     L  LSLA N L  +   A   L  L+ L L D
Sbjct: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD 176

Query: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLP 180
           N L +L+   L  LPAL +L L GNPW C C    L +W++ +   LP    + + C  P
Sbjct: 177 NELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWP 234

Query: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 231
                  L   S+A+FS C   L+L DL ++   G A  + ++ S   L +
Sbjct: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285


>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score =  120 bits (301), Expect = 1e-27
 Identities = 79/250 (31%), Positives = 115/250 (46%), Gaps = 2/250 (0%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C  + L   P   PL+ R+L +  NRI  +P        DLVYLD +NN +R + + TF 
Sbjct: 39  CTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFI 98

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGVHEDAFETLESLQVLELN 120
           G  KL++LDLS NNLT +    F     LV+L++ANN +L+ +H+  F    SL+ L+L 
Sbjct: 99  GVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLR 158

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           +  L++L  AAL  L  L +L L GNPW C+C F   F+         P       C  P
Sbjct: 159 NTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLD-FAIFLIVFHMDPSDDLNATCVEP 217

Query: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCA 240
            E     +  +       C   L   D   ++  G  +  A  ++++         Q   
Sbjct: 218 TELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTR 277

Query: 241 PNKDAEDEDE 250
                EDEDE
Sbjct: 278 HKSSEEDEDE 287


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  105 bits (262), Expect = 4e-23
 Identities = 57/143 (39%), Positives = 79/143 (55%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N ++ +P   F     LV L   +N L ++ EGTF+  + L  L LSYN +T L AG FR
Sbjct: 275 NMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFR 334

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
               LVKL L +NNL  +H   F+ L  L++L L+ N L +L          L +L L G
Sbjct: 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHG 394

Query: 146 NPWLCDCDFAHLFSWIQENASKL 168
           NPW CDC  A+LF+W+Q+   +L
Sbjct: 395 NPWQCDCHLAYLFNWLQQYTDRL 417



 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 68/211 (32%), Positives = 90/211 (42%), Gaps = 18/211 (8%)

Query: 6   GLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 65
           GLP + D        L V G+    +  + F     L  L    N L +L EG F   A 
Sbjct: 95  GLPRLED--------LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA 146

Query: 66  LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 125
           L  L L  N L  L    F+    L  L+LA N L  + E+ F  L SLQ L+L++N L 
Sbjct: 147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALS 206

Query: 126 SLSVAALAALPALRSLRLDGN--PWLCDCDFAHLFS----WIQENA-SKLPKGLDEIQCS 178
            L       L +L+ L LD N    L    F+ LF     W+Q NA + LP  +     +
Sbjct: 207 GLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGN 266

Query: 179 LPMESRRIS-LRELSEASFSE--CRFSLSLT 206
           L   S + + LR L    F+   C   LSLT
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLT 297



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 44/142 (30%), Positives = 63/142 (44%), Gaps = 2/142 (1%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           ++ L +A N + ++PE+ F     L  L   NN+L  L +G F     L  L L  NN++
Sbjct: 171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS 230

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
           +L    F     L +L L  N +  +    F +L +L  L L  N LR L     A  P 
Sbjct: 231 ELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC 290

Query: 138 LRSLRLDGN--PWLCDCDFAHL 157
           L  L L  N    + +  FAHL
Sbjct: 291 LVGLSLTHNQLETVAEGTFAHL 312


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  105 bits (262), Expect = 4e-23
 Identities = 66/173 (38%), Positives = 87/173 (50%), Gaps = 4/173 (2%)

Query: 27  RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 86
           ++  +P + F     L YL  + NSL  L++  F+  A L  L L  N L  L    FR 
Sbjct: 142 QLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRG 201

Query: 87  AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 146
            G L +L L  N L GVH  AF  L  L +L L +N+L SL   ALA LP+L  LRL+ N
Sbjct: 202 LGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261

Query: 147 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSEC 199
           PW CDC    L++W Q    +      ++ C+ P E +   LR L EA F  C
Sbjct: 262 PWACDCRARPLWAWFQ----RARVSSSDVTCATPPERQGRDLRALREADFQAC 310



 Score = 48.1 bits (113), Expect = 7e-06
 Identities = 39/106 (36%), Positives = 53/106 (50%), Gaps = 3/106 (2%)

Query: 45  LDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGV 103
           L  +NN +R+L  GTF   + L+ L L  NNL+ +  G FR    L +L L +N +L  +
Sbjct: 65  LFLQNNLIRTLRPGTF--GSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122

Query: 104 HEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWL 149
             D F+ LE LQ L L    L SL       L +L+ L L  N  L
Sbjct: 123 EPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLL 168


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 98.6 bits (244), Expect = 5e-21
 Identities = 69/220 (31%), Positives = 97/220 (44%), Gaps = 28/220 (12%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC    L SVP   P +  +L + GN I RI +  F     L  L    N + ++E G F
Sbjct: 40  DCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAF 99

Query: 61  S------------------------GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLA 96
                                    G+AKL  LDLS N +  +   AFR A  +  L L 
Sbjct: 100 QDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLD 159

Query: 97  NNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAH 156
            N +  + + AF  L  L+VL LN+NN+  LSVA+   +P LR+ RL  N   CDC  A 
Sbjct: 160 YNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAW 219

Query: 157 LFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASF 196
           L  W+++     P+     QC  P   R  ++ E+ +  F
Sbjct: 220 LSDWLRQR----PRVGLYTQCMGPSHLRGHNVAEVQKREF 255



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 59/202 (29%), Positives = 96/202 (47%), Gaps = 7/202 (3%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DCR +GL  +P   P  + ++ +  N I+ IP   F  Y  L  +D  NN +  L    F
Sbjct: 285 DCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAF 344

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
            G   L  L L  N +T+L    F     L  L L  N +  +  DAF+ L +L +L L 
Sbjct: 345 QGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLY 404

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           DN L++++    + L A++++ L  NP++CDC   HL  W+ +     P      +C+ P
Sbjct: 405 DNKLQTIAKGTFSPLRAIQTMHLAQNPFICDC---HL-KWLADYLHTNPIETSGARCTSP 460

Query: 181 MESRRISLRELSEASFSECRFS 202
              RR++ + + +    + R S
Sbjct: 461 ---RRLANKRIGQIKSKKFRCS 479



 Score = 74.7 bits (182), Expect = 7e-14
 Identities = 51/198 (25%), Positives = 96/198 (48%), Gaps = 5/198 (2%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPED-FFIFYGDLVYLDFRNNSLRSLEEGT 59
           DC ++ L  +P+  P    +L +  N    +     F     L  ++F NN +  +EEG 
Sbjct: 518 DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGA 577

Query: 60  FSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLEL 119
           F G++ +  + L+ N L  +    F+    L  L L +N +  V  D+F  L S+++L L
Sbjct: 578 FEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSL 637

Query: 120 NDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSL 179
            DN + +++  A   L +L +L L  NP+ C+C  A L  W+++   ++  G    +C  
Sbjct: 638 YDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTG--NPRCQK 693

Query: 180 PMESRRISLRELSEASFS 197
           P   + I +++++   F+
Sbjct: 694 PYFLKEIPIQDVAIQDFT 711



 Score = 69.7 bits (169), Expect = 2e-12
 Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 25/161 (15%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C ++GL  +P   P DV +L + GN+   +P++    Y  L  +D  NN + +L   +FS
Sbjct: 740 CSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN-YKHLTLIDLSNNRISTLSNQSFS 798

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
              +L+ L LSYN L                          +    F+ L+SL++L L+ 
Sbjct: 799 NMTQLLTLILSYNRLRC------------------------IPPRTFDGLKSLRLLSLHG 834

Query: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQ 162
           N++  +   A   L AL  L +  NP  CDC+   L  W++
Sbjct: 835 NDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVK 875


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 98.6 bits (244), Expect = 5e-21
 Identities = 68/221 (30%), Positives = 103/221 (46%), Gaps = 28/221 (12%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC   GL ++P   P +  +L + GN I RI ++ F     L  L    N + ++E G F
Sbjct: 46  DCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAF 105

Query: 61  SGSAKL----------------VF--------LDLSYNNLTQLGAGAFRSAGRLVKLSLA 96
               +L                +F        LDLS N +  +   AFR A  L  L L 
Sbjct: 106 DDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLD 165

Query: 97  NNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAH 156
            N +  + E AF  L  L+VL LN+NN+ ++ V++   +P LR+ RL  N   CDC  A 
Sbjct: 166 KNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAW 225

Query: 157 LFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 197
           L  W+++  +    GL   QCS P   R +++ E+ ++ FS
Sbjct: 226 LSQWLRQRPT---IGL-FTQCSGPASLRGLNVAEVQKSEFS 262



 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 60/202 (29%), Positives = 99/202 (49%), Gaps = 7/202 (3%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DCR +GL ++P   P  + ++ +  N I+ IP   F  Y  L  +D  NN +  +    F
Sbjct: 294 DCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAF 353

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
            G   L  L L  N +T L  G F     L  L L  N +  +  DAF+ L++L +L L 
Sbjct: 354 QGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLY 413

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           DN ++SL+     +L A+++L L  NP++CDC+   L  +++ N    P      +C+ P
Sbjct: 414 DNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTN----PIETSGARCASP 469

Query: 181 MESRRISLRELSEASFSECRFS 202
              RR++ + + +    + R S
Sbjct: 470 ---RRLANKRIGQIKSKKFRCS 488



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 57/197 (28%), Positives = 97/197 (49%), Gaps = 5/197 (2%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPED-FFIFYGDLVYLDFRNNSLRSLEEGT 59
           +C    L  +P+  P    +L +  N I  +     F     L  ++  NN +  +E+G 
Sbjct: 525 ECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGA 584

Query: 60  FSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLEL 119
           F G+A +  L L+ N L  + +G FR    L  L L NN +  +H D+F  L ++++L L
Sbjct: 585 FEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSL 644

Query: 120 NDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSL 179
            DN + ++S  A   L +L +L L  NP+ C+C  A L  W+++   K+  G    +C  
Sbjct: 645 YDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKR--KIVTG--NPRCQN 700

Query: 180 PMESRRISLRELSEASF 196
           P   R+I L++++   F
Sbjct: 701 PDFLRQIPLQDVAFPDF 717



 Score = 65.1 bits (157), Expect = 6e-11
 Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 25/161 (15%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C ++ L ++P   P +V +L + GN+   +P                         G  S
Sbjct: 747 CSNKHLRALPKGIPKNVTELYLDGNQFTLVP-------------------------GQLS 781

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
               L  +DLS N ++ L   +F +  +L  L L+ N L  +   AF+ L SL++L L+ 
Sbjct: 782 TFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHG 841

Query: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQ 162
           N++ +L     A + +L  L +  NP  CDC    L SW++
Sbjct: 842 NDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK 882


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 3/200 (1%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  +GL  +P   P   R L +  N+I  +P   F     L+ L+  NNSL +L  G F
Sbjct: 35  DCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAF 94

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
            G   L  L+L+ N+L  L +  F S  +L +L L++NN+  +     ET E+L +L + 
Sbjct: 95  HGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQ 154

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL-DEIQCSL 179
            N L+ L  A L ++P++R L L  N W C+C    L  W+++   K   GL D I C  
Sbjct: 155 QNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYK--GGLTDGIICES 212

Query: 180 PMESRRISLRELSEASFSEC 199
           P   +   L  +    +  C
Sbjct: 213 PDTWKGKDLLRIPHELYQPC 232


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  R L SVP  FP +V  L ++ NR+  +PE  F     L  L   +N +R++  G  
Sbjct: 35  DCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGAL 94

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  + L  LDLS+N ++        +   L  L + +N L  +  DAF +L +L+ L+LN
Sbjct: 95  ASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLN 154

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
            N L +L+      L AL  L+++ NP+ C C    L +W    A  +P+  D I C+ P
Sbjct: 155 HNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  R L SVP  FP +V  L ++ NR+  +PE  F     L  L   +N +R++  G  
Sbjct: 35  DCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGAL 94

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  + L  LDLS+N ++        +   L  L + +N L  +  DAF +L +L+ L+LN
Sbjct: 95  ASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLN 154

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
            N L +L+      L AL  L+++ NP+ C C    L +W    A  +P+  D I C+ P
Sbjct: 155 HNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 95.1 bits (235), Expect = 5e-20
 Identities = 62/202 (30%), Positives = 88/202 (43%), Gaps = 7/202 (3%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC   GL +VP   P   R LL+  N++  +P   F     L  LD  NN L  L    F
Sbjct: 53  DCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIF 112

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
                L  L L  N++  L     R +  L  L L+ N L  +    F+ L +L+ L L 
Sbjct: 113 GDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLR 172

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDC---DFAHLFSWIQENASKLPKGLDEIQC 177
            N L++L       L  L+ L++  NPW CDC   +F H   W      +    LD++ C
Sbjct: 173 SNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGR----LDQLAC 228

Query: 178 SLPMESRRISLRELSEASFSEC 199
           +LP E R   +R +    F+ C
Sbjct: 229 TLPKELRGKDMRMVPMEMFNYC 250


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 94.7 bits (234), Expect = 7e-20
 Identities = 60/172 (34%), Positives = 83/172 (48%), Gaps = 4/172 (2%)

Query: 28  IQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSA 87
           +Q +    F     L YL  ++N+L++L + TF     L  L L  N ++ +   AFR  
Sbjct: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL 201

Query: 88  GRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNP 147
             L +L L  N +  VH  AF  L  L  L L  NNL +L   ALA L AL+ LRL+ NP
Sbjct: 202 HSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNP 261

Query: 148 WLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSEC 199
           W+CDC    L++W+Q    K      E+ CSLP       L+ L+      C
Sbjct: 262 WVCDCRARPLWAWLQ----KFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGC 309


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 94.4 bits (233), Expect = 9e-20
 Identities = 59/202 (29%), Positives = 98/202 (48%), Gaps = 7/202 (3%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DCR +GL  +P   P  + ++ +  N I+ IP   F  Y  L  +D   N +  +    F
Sbjct: 292 DCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAF 351

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
            G   L  L L  N +T++  G F     L  L L  N +  +  + F+ L++L +L L 
Sbjct: 352 QGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLY 411

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           DN L+++S    A L ++++L L  NP++CDC    L  ++Q+N    P      +CS P
Sbjct: 412 DNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN----PIETSGARCSSP 467

Query: 181 MESRRISLRELSEASFSECRFS 202
              RR++ + +S+    + R S
Sbjct: 468 ---RRLANKRISQIKSKKFRCS 486



 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 55/187 (29%), Positives = 84/187 (44%), Gaps = 24/187 (12%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC   GL +VP   P +  +L +  N I RI +  F    +L  L   +N +  +E G F
Sbjct: 46  DCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAF 105

Query: 61  S------------------------GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLA 96
                                     + KL  LDLS N +  +   AFR    +  L L 
Sbjct: 106 QDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLD 165

Query: 97  NNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAH 156
           NN++  + + AF  L  L++L LN+NN+  + V +   +P +R+LRL  N   CDC  A 
Sbjct: 166 NNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAW 225

Query: 157 LFSWIQE 163
           L  W+++
Sbjct: 226 LSDWLRQ 232



 Score = 78.6 bits (192), Expect = 5e-15
 Identities = 56/217 (25%), Positives = 100/217 (46%), Gaps = 12/217 (5%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPED-FFIFYGDLVYLDFRNNSLRSLEEGT 59
           DC ++ L  +P   P  V  L +  N +  +     F    +L  ++  NN ++ + EG 
Sbjct: 517 DCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGA 576

Query: 60  FSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLEL 119
           F G+A +  L L+ N L  +    FR    L  L L +N +  V  D F  L S+++L L
Sbjct: 577 FDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSL 636

Query: 120 NDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSL 179
            DN + +++  A   L +L ++ L  NP+ C+C  A L  W+++   ++  G    +C  
Sbjct: 637 YDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKR--RIVSG--NPRCQK 692

Query: 180 PMESRRISLRELSEASF-------SECRFSLSLTDLC 209
           P   + I +++++   F       S C+ S    + C
Sbjct: 693 PFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQC 729



 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 55/183 (30%), Positives = 78/183 (42%), Gaps = 27/183 (14%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C ++GL ++P   P DV +L + GN +  +P +       L  +D  NNS+  L   TFS
Sbjct: 738 CSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALR-HLTLIDLSNNSISMLTNYTFS 796

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
             + L  L LSYN L                        + VH  AF  L SL+VL L+ 
Sbjct: 797 NMSHLSTLILSYNRL----------------------RCIPVH--AFNGLRSLRVLTLHG 832

Query: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPM 181
           N++ S+   +   L +L  L L  NP  CDC    L  W++  A     G+       PM
Sbjct: 833 NDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK--AGYKEPGIARCSSPEPM 890

Query: 182 ESR 184
             R
Sbjct: 891 ADR 893


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 61/179 (34%), Positives = 92/179 (51%), Gaps = 1/179 (0%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R+L +  N ++ +    F     L+ L   +N LR L  G F G A+L  L L+ N L 
Sbjct: 76  LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
           +L    F    RL +L L  N++  + + A   L SL +L+L+ N L ++S  AL  L +
Sbjct: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195

Query: 138 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLD-EIQCSLPMESRRISLRELSEAS 195
           L+ LRL  NPW CDC    L +WI+E   +L    D +I C+ P      SL ++S +S
Sbjct: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSS 254


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score = 87.0 bits (214), Expect = 1e-17
 Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 6/176 (3%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R+L ++ N I+ I    F    +L YL  +N+ +R++    FSG   L  L LS+N+L 
Sbjct: 230 LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLE 289

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETL-ESLQVLELNDNNLRSLSVAALAALP 136
            L +  F     L+ L L  N ++ +  D FE +  SL++L L+ NNL +L    L  L 
Sbjct: 290 NLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLS 349

Query: 137 ALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELS 192
           +L  L+ + NPW C+C    L  W+  +A  L      I C  P   R  +LR ++
Sbjct: 350 SLIHLQANSNPWECNCKLLGLRDWLASSAITL-----NIYCQNPPSMRGRALRYIN 400



 Score = 71.2 bits (173), Expect = 8e-13
 Identities = 57/195 (29%), Positives = 77/195 (39%), Gaps = 48/195 (24%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPED------------------------FF 36
           +CR+ GL S+P  FP     L + GN I  I E                          F
Sbjct: 45  NCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAF 104

Query: 37  IFYGDLVYLDFRNNSLRSLEEGTFSGSAKL------------------------VFLDLS 72
           +    L +L   NN ++ L+ G F G   L                         +L+L 
Sbjct: 105 VQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQ 164

Query: 73  YNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAAL 132
            N LT LG+G F     L  L L+NNN++ + E  F+ LE+L  L L  NNL  +   A 
Sbjct: 165 RNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAF 224

Query: 133 AALPALRSLRLDGNP 147
             L +LR L L  NP
Sbjct: 225 EVLKSLRRLSLSHNP 239



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 44/128 (34%), Positives = 65/128 (50%)

Query: 16  LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 75
           L++R L +  N++  +P   F     + YL+ + N L  L  GTF G   L  LDLS NN
Sbjct: 132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191

Query: 76  LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 135
           + ++    F+    L  L L +NNL  V  +AFE L+SL+ L L+ N + ++   A   L
Sbjct: 192 ILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGL 251

Query: 136 PALRSLRL 143
             L  L L
Sbjct: 252 ANLEYLLL 259


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 87.0 bits (214), Expect = 1e-17
 Identities = 69/231 (29%), Positives = 93/231 (40%), Gaps = 37/231 (16%)

Query: 2   CRDRGLPSVPDPFPLDVRK------------------------LLVAGNRIQRIPEDFFI 37
           C  R L S+PD  P +V +                        L++  N I  IP+  F 
Sbjct: 43  CTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFS 102

Query: 38  FYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLAN 97
               L  L    N +R L++ TF G   L  L + +NN+  +    F     L  + L  
Sbjct: 103 DLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEG 162

Query: 98  NNLVGVHEDAFETLESLQV--------LELNDNNLRSLSVAALAALPALRSLRLDGNPWL 149
           N L  +H D F +L  LQ+        L L+DN L SL    ++ +P L SL L GNPW 
Sbjct: 163 NQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWT 222

Query: 150 CDCDFAHLFSWIQENASKLPKGLDEI-----QCSLPMESRRISLRELSEAS 195
           CDC    L  WIQE    +    D       QC L M  R    + L+  S
Sbjct: 223 CDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVS 273


>gi|40217825 slit and trk like 6 [Homo sapiens]
          Length = 841

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 32/219 (14%)

Query: 2   CRDRGLPSVPD--PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGT 59
           C++R + S+ D  P P + RKL++AGN I  + +   + Y  L  L   NN +  LEEG+
Sbjct: 347 CQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGS 406

Query: 60  FSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLEL 119
           F    +L  L L+ N+LT+L  G F     L  L L  N +  +    F  +  L+VL L
Sbjct: 407 FMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYL 466

Query: 120 NDNNLRSLSVAALAALP------------------------ALRSLRLDGNPWLCDCDFA 155
           N+N L+ L     + +P                         L  + L+ NPW C CD  
Sbjct: 467 NNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLV 526

Query: 156 HLFSWIQENASKLPKG--LDEIQCSLPMESRRISLRELS 192
            L  WIQ    KL K    D+I C+ P    +  L+ L+
Sbjct: 527 GLQQWIQ----KLSKNTVTDDILCTSPGHLDKKELKALN 561



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 45/138 (32%), Positives = 65/138 (47%), Gaps = 2/138 (1%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N I  I    F   G L  L   +NSL  L+E TF G   L FL    N +T +   AF 
Sbjct: 98  NNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFS 157

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS-VAALAALPALRSLRLD 144
              RL  L L +N +  +  + F  +  L  L+L  N L++L  V  L  +  +  L+L+
Sbjct: 158 KLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLE 216

Query: 145 GNPWLCDCDFAHLFSWIQ 162
            N W C+CD   L +W++
Sbjct: 217 DNKWACNCDLLQLKTWLE 234



 Score = 33.9 bits (76), Expect = 0.14
 Identities = 18/58 (31%), Positives = 29/58 (50%)

Query: 89  RLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 146
           R  +LSL NN L  +H + F  L +   + L  NN+  + + A   L  L+ L ++ N
Sbjct: 65  RPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHN 122


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 55/180 (30%), Positives = 87/180 (48%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  + L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  
Sbjct: 36  DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGAL 95

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  ++L  LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N
Sbjct: 96  AVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN 155

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           +N LR+L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 156 NNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 55/180 (30%), Positives = 87/180 (48%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  + L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  
Sbjct: 36  DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGAL 95

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  ++L  LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N
Sbjct: 96  AVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN 155

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           +N LR+L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 156 NNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 55/180 (30%), Positives = 87/180 (48%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  + L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  
Sbjct: 36  DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGAL 95

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  ++L  LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N
Sbjct: 96  AVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN 155

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           +N LR+L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 156 NNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 55/180 (30%), Positives = 87/180 (48%), Gaps = 1/180 (0%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           DC  + L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  
Sbjct: 36  DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGAL 95

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
           +  ++L  LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N
Sbjct: 96  AVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN 155

Query: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
           +N LR+L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 156 NNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
          Length = 820

 Score = 85.5 bits (210), Expect = 4e-17
 Identities = 52/174 (29%), Positives = 82/174 (47%), Gaps = 1/174 (0%)

Query: 9   SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 68
           ++P      V  L +  N+++ +       +G+L  L+   N +  +E+G F G + L  
Sbjct: 48  TIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQV 107

Query: 69  LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 128
           L L YN L+ L  G  R   RL  L + +N +  V   AF    SL  ++L+ N L  L 
Sbjct: 108 LQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLD 167

Query: 129 VAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPME 182
            A  A+L +L    L GNP+ C+CD     +W+    + + K  D +QC  P E
Sbjct: 168 GATFASLASLMVCELAGNPFNCECDLFGFLAWLVV-FNNVTKNYDRLQCESPRE 220


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 81.6 bits (200), Expect = 6e-16
 Identities = 51/135 (37%), Positives = 64/135 (47%)

Query: 28  IQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSA 87
           +  +P   F     L YL  ++N +  L++  F     L  L L  N L  LG G FR  
Sbjct: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGL 196

Query: 88  GRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNP 147
             L +L L  N L  VH  AF  L  L  L L +N+L  L    LA L AL  LRL+GNP
Sbjct: 197 VNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNP 256

Query: 148 WLCDCDFAHLFSWIQ 162
           W C C    L+ W+Q
Sbjct: 257 WDCGCRARSLWEWLQ 271


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 36/218 (16%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +  L + G+ + RI    F     L  L  ++N L  +EE +  G A+L+ LDL+ N LT
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL-- 135
            L    F+  G+L  L L+ N L  +  DA   L+    L+++ N L +L  + LA L  
Sbjct: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGR 545

Query: 136 ------------------PALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL----- 172
                             P L  L L+GNPW C C    L  +  +N S +P+ +     
Sbjct: 546 LRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 605

Query: 173 -----------DEIQCSLPMESRRISLRELSEASFSEC 199
                      + I C+ P E   + LR+LSEA F+ C
Sbjct: 606 GDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643



 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 51/145 (35%), Positives = 64/145 (44%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C  R L  +PD  P   + L + GN +  +P   F     L +L+ +   L SLE     
Sbjct: 98  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
           G   L  L L  N L  L  G F     L  L L+NN L  + +  FE L SL  L L  
Sbjct: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217

Query: 122 NNLRSLSVAALAALPALRSLRLDGN 146
           N+L  L  AA   L +LR L L GN
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGN 242



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 43/121 (35%), Positives = 59/121 (48%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N+++ +    F     L  L   NN L  LE+G F G   L  L+L +N+L  L   AFR
Sbjct: 170 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 229

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
             G L +L LA N L  +    F  L  L+ L+L+ N LR++       LP L+ L LD 
Sbjct: 230 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 289

Query: 146 N 146
           N
Sbjct: 290 N 290



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 22/198 (11%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R+L++AGNR+  +    F    +L  LD   N+LR+++   F    +L  L L  N + 
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +  GAF     L  L L++N + G+ ED F  L  L+VL L+ N + SL       L  
Sbjct: 294 AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHF 353

Query: 138 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 197
           L  L+L  N              I++ A +  +GL +++  L ++  +  L+E+   +F 
Sbjct: 354 LEELQLGHNR-------------IRQLAERSFEGLGQLEV-LTLDHNQ--LQEVKAGAF- 396

Query: 198 ECRFSLSLTDLCIIIFSG 215
                L LT++ ++  SG
Sbjct: 397 -----LGLTNVAVMNLSG 409



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 40/129 (31%), Positives = 62/129 (48%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           ++KL +  N I  +    F+    L +LD  +N +  L E TF G   L  L LS+N + 
Sbjct: 282 LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 341

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            L    F+    L +L L +N +  + E +FE L  L+VL L+ N L+ +   A   L  
Sbjct: 342 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 401

Query: 138 LRSLRLDGN 146
           +  + L GN
Sbjct: 402 VAVMNLSGN 410



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 43/129 (33%), Positives = 64/129 (49%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R L ++ NR+  + ED F     L  L   +N++ SL   TF     L  L L +N + 
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
           QL   +F   G+L  L+L +N L  V   AF  L ++ V+ L+ N LR+L       L  
Sbjct: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425

Query: 138 LRSLRLDGN 146
           L SL L+G+
Sbjct: 426 LHSLHLEGS 434



 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 44/121 (36%), Positives = 57/121 (47%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N +  +P+  F   G L  L    N L  L+   FSG A+L  LDLS N L  + A  F 
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
              RL KL L  N +  V   AF  L++L+ L+L+ N +  L       L  LR LRL  
Sbjct: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337

Query: 146 N 146
           N
Sbjct: 338 N 338



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 40/129 (31%), Positives = 59/129 (45%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           + +L +  NRI+++ E  F   G L  L   +N L+ ++ G F G   +  ++LS N L 
Sbjct: 354 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 413

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            L    FR  G+L  L L  + L  +    F  L  L+ L L DN L  +   +L  L  
Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473

Query: 138 LRSLRLDGN 146
           L  L L  N
Sbjct: 474 LLELDLTSN 482



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 40/124 (32%), Positives = 57/124 (45%)

Query: 23  VAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAG 82
           ++ NR+ R+ +  F   G L  L+   NSL  L +  F G   L  L L+ N L  L   
Sbjct: 191 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 250

Query: 83  AFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLR 142
            F     L +L L+ N L  +  + F  L  LQ L L+ N + +++  A   L ALR L 
Sbjct: 251 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 310

Query: 143 LDGN 146
           L  N
Sbjct: 311 LSHN 314



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 2/137 (1%)

Query: 12  DPFP--LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFL 69
           D FP  L +R L ++ N I  +    F     L  L   +N +R L E +F G  +L  L
Sbjct: 322 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 381

Query: 70  DLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSV 129
            L +N L ++ AGAF     +  ++L+ N L  + E  F  L  L  L L  + L  +  
Sbjct: 382 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 441

Query: 130 AALAALPALRSLRLDGN 146
                L  LR L L  N
Sbjct: 442 HTFTGLSGLRRLFLKDN 458


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 36/218 (16%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +  L + G+ + RI    F     L  L  ++N L  +EE +  G A+L+ LDL+ N LT
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL-- 135
            L    F+  G+L  L L+ N L  +  DA   L+    L+++ N L +L  + LA L  
Sbjct: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGR 507

Query: 136 ------------------PALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL----- 172
                             P L  L L+GNPW C C    L  +  +N S +P+ +     
Sbjct: 508 LRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 567

Query: 173 -----------DEIQCSLPMESRRISLRELSEASFSEC 199
                      + I C+ P E   + LR+LSEA F+ C
Sbjct: 568 GDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605



 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 51/145 (35%), Positives = 64/145 (44%)

Query: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61
           C  R L  +PD  P   + L + GN +  +P   F     L +L+ +   L SLE     
Sbjct: 60  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119

Query: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121
           G   L  L L  N L  L  G F     L  L L+NN L  + +  FE L SL  L L  
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179

Query: 122 NNLRSLSVAALAALPALRSLRLDGN 146
           N+L  L  AA   L +LR L L GN
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGN 204



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 43/121 (35%), Positives = 59/121 (48%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N+++ +    F     L  L   NN L  LE+G F G   L  L+L +N+L  L   AFR
Sbjct: 132 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 191

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
             G L +L LA N L  +    F  L  L+ L+L+ N LR++       LP L+ L LD 
Sbjct: 192 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251

Query: 146 N 146
           N
Sbjct: 252 N 252



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 22/198 (11%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R+L++AGNR+  +    F    +L  LD   N+LR+++   F    +L  L L  N + 
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +  GAF     L  L L++N + G+ ED F  L  L+VL L+ N + SL       L  
Sbjct: 256 AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHF 315

Query: 138 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 197
           L  L+L  N              I++ A +  +GL +++  L ++  +  L+E+   +F 
Sbjct: 316 LEELQLGHNR-------------IRQLAERSFEGLGQLEV-LTLDHNQ--LQEVKAGAF- 358

Query: 198 ECRFSLSLTDLCIIIFSG 215
                L LT++ ++  SG
Sbjct: 359 -----LGLTNVAVMNLSG 371



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 40/129 (31%), Positives = 62/129 (48%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           ++KL +  N I  +    F+    L +LD  +N +  L E TF G   L  L LS+N + 
Sbjct: 244 LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 303

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            L    F+    L +L L +N +  + E +FE L  L+VL L+ N L+ +   A   L  
Sbjct: 304 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363

Query: 138 LRSLRLDGN 146
           +  + L GN
Sbjct: 364 VAVMNLSGN 372



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 43/129 (33%), Positives = 64/129 (49%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R L ++ NR+  + ED F     L  L   +N++ SL   TF     L  L L +N + 
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
           QL   +F   G+L  L+L +N L  V   AF  L ++ V+ L+ N LR+L       L  
Sbjct: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387

Query: 138 LRSLRLDGN 146
           L SL L+G+
Sbjct: 388 LHSLHLEGS 396



 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 44/121 (36%), Positives = 57/121 (47%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           N +  +P+  F   G L  L    N L  L+   FSG A+L  LDLS N L  + A  F 
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
              RL KL L  N +  V   AF  L++L+ L+L+ N +  L       L  LR LRL  
Sbjct: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299

Query: 146 N 146
           N
Sbjct: 300 N 300



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 40/129 (31%), Positives = 59/129 (45%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           + +L +  NRI+++ E  F   G L  L   +N L+ ++ G F G   +  ++LS N L 
Sbjct: 316 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 375

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            L    FR  G+L  L L  + L  +    F  L  L+ L L DN L  +   +L  L  
Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435

Query: 138 LRSLRLDGN 146
           L  L L  N
Sbjct: 436 LLELDLTSN 444



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 40/124 (32%), Positives = 57/124 (45%)

Query: 23  VAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAG 82
           ++ NR+ R+ +  F   G L  L+   NSL  L +  F G   L  L L+ N L  L   
Sbjct: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212

Query: 83  AFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLR 142
            F     L +L L+ N L  +  + F  L  LQ L L+ N + +++  A   L ALR L 
Sbjct: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272

Query: 143 LDGN 146
           L  N
Sbjct: 273 LSHN 276



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 2/137 (1%)

Query: 12  DPFP--LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFL 69
           D FP  L +R L ++ N I  +    F     L  L   +N +R L E +F G  +L  L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343

Query: 70  DLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSV 129
            L +N L ++ AGAF     +  ++L+ N L  + E  F  L  L  L L  + L  +  
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403

Query: 130 AALAALPALRSLRLDGN 146
                L  LR L L  N
Sbjct: 404 HTFTGLSGLRRLFLKDN 420


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 56/177 (31%), Positives = 80/177 (45%), Gaps = 4/177 (2%)

Query: 13  PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLS 72
           P P ++R+L +  N I  +P++ F     L  L    N +  +  G F+G  +L  L L 
Sbjct: 297 PMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 355

Query: 73  YNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAAL 132
            N L  L    FR    L  +SL NN L  +  + F  +  L  ++L +N L +L +   
Sbjct: 356 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF 415

Query: 133 AALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQ-CSLPMESRRISL 188
             L  L  LRL  NPW CD D   L +W+  N  +L  G D +  C  P   R  SL
Sbjct: 416 DHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRL--GTDTVPVCFSPANVRGQSL 470



 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 40/146 (27%), Positives = 62/146 (42%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           +C    + +VP P P +   L +    I  + E  F+    L+ L    N L  +  G F
Sbjct: 44  ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 103

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
                L +L L+ N L  L  G F+    L  L L++N L+ +    F    +L+ L+L+
Sbjct: 104 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 163

Query: 121 DNNLRSLSVAALAALPALRSLRLDGN 146
            N+L  +   A   L  L  L L  N
Sbjct: 164 GNHLEYIPDGAFDHLVGLTKLNLGKN 189



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 44/126 (34%), Positives = 56/126 (44%)

Query: 21  LLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLG 80
           L +  N + RI    F   G L YL   NN L+ L  G F G   L  L LS N L Q+ 
Sbjct: 88  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147

Query: 81  AGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRS 140
              F     L +L L  N+L  + + AF+ L  L  L L  N+L  +S      L  L+ 
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207

Query: 141 LRLDGN 146
           LRL  N
Sbjct: 208 LRLYEN 213



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 41/129 (31%), Positives = 61/129 (47%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R L +A N++Q +P   F     L  L   +N L  ++   FS  + L  L L  N+L 
Sbjct: 109 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 168

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +  GAF     L KL+L  N+L  +    F+ L +LQVL L +N L  + +     L  
Sbjct: 169 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 228

Query: 138 LRSLRLDGN 146
           L+ L L  N
Sbjct: 229 LQELALQQN 237



 Score = 57.8 bits (138), Expect = 9e-09
 Identities = 41/127 (32%), Positives = 56/127 (44%)

Query: 20  KLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQL 79
           KL +  N +  I    F   G+L  L    N L  +  GTF G   L  L L  N +  L
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 242

Query: 80  GAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALR 139
             G F +   L +L L+NN++  +    F  L  L  L L  N+L+ LS+     +P LR
Sbjct: 243 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 302

Query: 140 SLRLDGN 146
            L L  N
Sbjct: 303 ELWLYDN 309



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 38/130 (29%), Positives = 59/130 (45%)

Query: 17  DVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNL 76
           ++++L + GN ++ IP+  F     L  L+   NSL  +    F     L  L L  N L
Sbjct: 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215

Query: 77  TQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALP 136
           T +  G F     L +L+L  N +  +    F    +LQ L L++N++  L  +    LP
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 275

Query: 137 ALRSLRLDGN 146
            L  L L GN
Sbjct: 276 QLNRLTLFGN 285



 Score = 51.2 bits (121), Expect = 9e-07
 Identities = 37/129 (28%), Positives = 55/129 (42%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +  LL++ N++ +I    F    +L  L    N L  + +G F     L  L+L  N+LT
Sbjct: 133 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 192

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +    F+  G L  L L  N L  +    F+ L +LQ L L  N +  LS         
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 252

Query: 138 LRSLRLDGN 146
           L+ L L  N
Sbjct: 253 LQRLYLSNN 261



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 38/131 (29%), Positives = 61/131 (46%)

Query: 16  LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 75
           +++++L +  N+I  +    F    +L  L   NN +  L    F    +L  L L  N+
Sbjct: 227 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 286

Query: 76  LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 135
           L +L  G F     L +L L +N++  + ++ F  L  LQVL L+ N +  +S  A   L
Sbjct: 287 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 346

Query: 136 PALRSLRLDGN 146
             LR L L  N
Sbjct: 347 TELRELSLHTN 357



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 37/121 (30%), Positives = 57/121 (47%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           NR+  IP   F    +L  L  + N +  L  G F  +  L  L LS N+++QL    F 
Sbjct: 213 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFM 272

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
              +L +L+L  N+L  +    F  + +L+ L L DN++ SL     + L  L+ L L  
Sbjct: 273 QLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 332

Query: 146 N 146
           N
Sbjct: 333 N 333


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 56/177 (31%), Positives = 80/177 (45%), Gaps = 4/177 (2%)

Query: 13  PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLS 72
           P P ++R+L +  N I  +P++ F     L  L    N +  +  G F+G  +L  L L 
Sbjct: 291 PMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 349

Query: 73  YNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAAL 132
            N L  L    FR    L  +SL NN L  +  + F  +  L  ++L +N L +L +   
Sbjct: 350 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF 409

Query: 133 AALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQ-CSLPMESRRISL 188
             L  L  LRL  NPW CD D   L +W+  N  +L  G D +  C  P   R  SL
Sbjct: 410 DHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRL--GTDTVPVCFSPANVRGQSL 464



 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 40/146 (27%), Positives = 62/146 (42%)

Query: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
           +C    + +VP P P +   L +    I  + E  F+    L+ L    N L  +  G F
Sbjct: 38  ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 97

Query: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
                L +L L+ N L  L  G F+    L  L L++N L+ +    F    +L+ L+L+
Sbjct: 98  RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 157

Query: 121 DNNLRSLSVAALAALPALRSLRLDGN 146
            N+L  +   A   L  L  L L  N
Sbjct: 158 GNHLEYIPDGAFDHLVGLTKLNLGKN 183



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 44/126 (34%), Positives = 56/126 (44%)

Query: 21  LLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLG 80
           L +  N + RI    F   G L YL   NN L+ L  G F G   L  L LS N L Q+ 
Sbjct: 82  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141

Query: 81  AGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRS 140
              F     L +L L  N+L  + + AF+ L  L  L L  N+L  +S      L  L+ 
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201

Query: 141 LRLDGN 146
           LRL  N
Sbjct: 202 LRLYEN 207



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 41/129 (31%), Positives = 61/129 (47%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +R L +A N++Q +P   F     L  L   +N L  ++   FS  + L  L L  N+L 
Sbjct: 103 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 162

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +  GAF     L KL+L  N+L  +    F+ L +LQVL L +N L  + +     L  
Sbjct: 163 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 222

Query: 138 LRSLRLDGN 146
           L+ L L  N
Sbjct: 223 LQELALQQN 231



 Score = 57.8 bits (138), Expect = 9e-09
 Identities = 41/127 (32%), Positives = 56/127 (44%)

Query: 20  KLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQL 79
           KL +  N +  I    F   G+L  L    N L  +  GTF G   L  L L  N +  L
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236

Query: 80  GAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALR 139
             G F +   L +L L+NN++  +    F  L  L  L L  N+L+ LS+     +P LR
Sbjct: 237 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 296

Query: 140 SLRLDGN 146
            L L  N
Sbjct: 297 ELWLYDN 303



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 38/130 (29%), Positives = 59/130 (45%)

Query: 17  DVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNL 76
           ++++L + GN ++ IP+  F     L  L+   NSL  +    F     L  L L  N L
Sbjct: 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209

Query: 77  TQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALP 136
           T +  G F     L +L+L  N +  +    F    +LQ L L++N++  L  +    LP
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 269

Query: 137 ALRSLRLDGN 146
            L  L L GN
Sbjct: 270 QLNRLTLFGN 279



 Score = 51.2 bits (121), Expect = 9e-07
 Identities = 37/129 (28%), Positives = 55/129 (42%)

Query: 18  VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 77
           +  LL++ N++ +I    F    +L  L    N L  + +G F     L  L+L  N+LT
Sbjct: 127 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 186

Query: 78  QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 137
            +    F+  G L  L L  N L  +    F+ L +LQ L L  N +  LS         
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 246

Query: 138 LRSLRLDGN 146
           L+ L L  N
Sbjct: 247 LQRLYLSNN 255



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 38/131 (29%), Positives = 61/131 (46%)

Query: 16  LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 75
           +++++L +  N+I  +    F    +L  L   NN +  L    F    +L  L L  N+
Sbjct: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280

Query: 76  LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 135
           L +L  G F     L +L L +N++  + ++ F  L  LQVL L+ N +  +S  A   L
Sbjct: 281 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 340

Query: 136 PALRSLRLDGN 146
             LR L L  N
Sbjct: 341 TELRELSLHTN 351



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 37/121 (30%), Positives = 57/121 (47%)

Query: 26  NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 85
           NR+  IP   F    +L  L  + N +  L  G F  +  L  L LS N+++QL    F 
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFM 266

Query: 86  SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 145
              +L +L+L  N+L  +    F  + +L+ L L DN++ SL     + L  L+ L L  
Sbjct: 267 QLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 326

Query: 146 N 146
           N
Sbjct: 327 N 327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,001,342
Number of Sequences: 37866
Number of extensions: 360485
Number of successful extensions: 2575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 1088
Number of HSP's gapped (non-prelim): 809
length of query: 254
length of database: 18,247,518
effective HSP length: 100
effective length of query: 154
effective length of database: 14,460,918
effective search space: 2226981372
effective search space used: 2226981372
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.