Guide to the Human Genome
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Search of human proteins with 239752343

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239752343 PREDICTED: hypothetical protein [Homo sapiens]
         (518 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239752343 PREDICTED: hypothetical protein [Homo sapiens]          1065   0.0  
gi|239746856 PREDICTED: hypothetical protein XP_002343859 [Homo ...  1065   0.0  
gi|239757832 PREDICTED: hypothetical protein [Homo sapiens]          1012   0.0  
gi|223468693 hypothetical protein LOC100130361 [Homo sapiens]         728   0.0  
gi|223468690 hypothetical protein LOC100132994 [Homo sapiens]         728   0.0  
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    57   4e-08
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    57   4e-08
gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho...    55   2e-07
gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho...    55   2e-07
gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho...    55   2e-07
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]       55   2e-07
gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein ...    54   3e-07
gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein ...    54   3e-07
gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein ...    54   3e-07
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    49   1e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    49   1e-05
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      48   2e-05
gi|4504733 insulin receptor substrate 4 [Homo sapiens]                 47   5e-05
gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]               46   7e-05
gi|27262667 colony stimulating factor 1 isoform a precursor [Hom...    45   1e-04
gi|27262661 colony stimulating factor 1 isoform a precursor [Hom...    45   1e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    45   2e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    45   2e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    45   2e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    45   2e-04
gi|163965366 nascent polypeptide-associated complex alpha subuni...    45   2e-04
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          43   6e-04
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      42   0.001
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    42   0.001
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    42   0.001

>gi|239752343 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 518

 Score = 1065 bits (2753), Expect = 0.0
 Identities = 518/518 (100%), Positives = 518/518 (100%)

Query: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60
           MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT
Sbjct: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60

Query: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120
           DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG
Sbjct: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120

Query: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180
           HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER
Sbjct: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240
           GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP
Sbjct: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240

Query: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300
           GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV
Sbjct: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300

Query: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
           RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP
Sbjct: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360

Query: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
           VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL
Sbjct: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420

Query: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
           ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ
Sbjct: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480

Query: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518
           QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL
Sbjct: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518


>gi|239746856 PREDICTED: hypothetical protein XP_002343859 [Homo
           sapiens]
          Length = 518

 Score = 1065 bits (2753), Expect = 0.0
 Identities = 518/518 (100%), Positives = 518/518 (100%)

Query: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60
           MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT
Sbjct: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60

Query: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120
           DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG
Sbjct: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120

Query: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180
           HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER
Sbjct: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240
           GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP
Sbjct: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240

Query: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300
           GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV
Sbjct: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300

Query: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
           RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP
Sbjct: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360

Query: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
           VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL
Sbjct: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420

Query: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
           ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ
Sbjct: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480

Query: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518
           QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL
Sbjct: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518


>gi|239757832 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 503

 Score = 1012 bits (2617), Expect = 0.0
 Identities = 491/493 (99%), Positives = 492/493 (99%)

Query: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60
           MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT
Sbjct: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60

Query: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120
           DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG
Sbjct: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120

Query: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180
           HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER
Sbjct: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240
           GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP
Sbjct: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240

Query: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300
           GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV
Sbjct: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300

Query: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
           RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP
Sbjct: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360

Query: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
           VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL
Sbjct: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420

Query: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
           ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ
Sbjct: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480

Query: 481 QPPGAQGCPRCIL 493
           QPPGAQGCPR +L
Sbjct: 481 QPPGAQGCPRVML 493


>gi|223468693 hypothetical protein LOC100130361 [Homo sapiens]
          Length = 514

 Score =  728 bits (1878), Expect = 0.0
 Identities = 373/518 (72%), Positives = 407/518 (78%), Gaps = 4/518 (0%)

Query: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60
           MSS D+VSVC AG   EGG++AG+ TASPGAP    HG DL       G G GK ESGFT
Sbjct: 1   MSSPDKVSVCGAGFDLEGGKKAGSRTASPGAPGAHSHGLDLGV----PGSGDGKSESGFT 56

Query: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120
           DPE FSFESESELIEQGRVVLWG+EGRPGTPVDDQ    DYSFYLADEPA I+PP SVQG
Sbjct: 57  DPEGFSFESESELIEQGRVVLWGREGRPGTPVDDQGDVVDYSFYLADEPAAIVPPPSVQG 116

Query: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180
           HP PEGA A+GS + WAD EVGPS R  L  SPG+WQQASAG LHL  PGP  AW+NPER
Sbjct: 117 HPFPEGAAAEGSAENWADAEVGPSGRDVLGHSPGKWQQASAGRLHLCGPGPVRAWKNPER 176

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240
           GSKSR S +VDPQQPSA+GP  L T DSDSADESSDLP+++V I   EGSQAKPGSPKK 
Sbjct: 177 GSKSRWSLRVDPQQPSAKGPTRLPTHDSDSADESSDLPLMKVGICRNEGSQAKPGSPKKR 236

Query: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300
            DT  + SFH +ESYL V G  L S PR LTPV ERPAVGEL+    KKMQS  WGK  V
Sbjct: 237 ADTSRQASFHCKESYLPVPGRFLTSAPRGLTPVAERPAVGELEDSPQKKMQSRAWGKVEV 296

Query: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
           RPSCSGAA  G LP+G   RK+A  KKSL GA +LAL   FPA G+RLSA PP+PA+FPP
Sbjct: 297 RPSCSGAAAAGALPQGLSRRKMAGGKKSLGGASQLALGRGFPACGERLSAAPPEPATFPP 356

Query: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
            SGV   G S +P++PKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPT +P L
Sbjct: 357 FSGVRPQGMSKKPQKPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTHRPGL 416

Query: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
             LSVRRGE+SS DPNIRAPQ+ GTS+PSA++   LVPR HA SG+ QPPVHPPRPERQQ
Sbjct: 417 PRLSVRRGEFSSSDPNIRAPQLPGTSEPSAYSPGGLVPRRHAPSGNQQPPVHPPRPERQQ 476

Query: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518
           QPPGAQGCPRCI LQREIEDL  QLAAMQFLTDKFQDL
Sbjct: 477 QPPGAQGCPRCIWLQREIEDLTQQLAAMQFLTDKFQDL 514


>gi|223468690 hypothetical protein LOC100132994 [Homo sapiens]
          Length = 514

 Score =  728 bits (1878), Expect = 0.0
 Identities = 373/518 (72%), Positives = 407/518 (78%), Gaps = 4/518 (0%)

Query: 1   MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFT 60
           MSS D+VSVC AG   EGG++AG+ TASPGAP    HG DL       G G GK ESGFT
Sbjct: 1   MSSPDKVSVCGAGFDLEGGKKAGSRTASPGAPGAHSHGLDLGV----PGSGDGKSESGFT 56

Query: 61  DPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQG 120
           DPE FSFESESELIEQGRVVLWG+EGRPGTPVDDQ    DYSFYLADEPA I+PP SVQG
Sbjct: 57  DPEGFSFESESELIEQGRVVLWGREGRPGTPVDDQGDVVDYSFYLADEPAAIVPPPSVQG 116

Query: 121 HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPER 180
           HP PEGA A+GS + WAD EVGPS R  L  SPG+WQQASAG LHL  PGP  AW+NPER
Sbjct: 117 HPFPEGAAAEGSAENWADAEVGPSGRDVLGHSPGKWQQASAGRLHLCGPGPVRAWKNPER 176

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKP 240
           GSKSR S +VDPQQPSA+GP  L T DSDSADESSDLP+++V I   EGSQAKPGSPKK 
Sbjct: 177 GSKSRWSLRVDPQQPSAKGPTRLPTHDSDSADESSDLPLMKVGICRNEGSQAKPGSPKKR 236

Query: 241 GDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGV 300
            DT  + SFH +ESYL V G  L S PR LTPV ERPAVGEL+    KKMQS  WGK  V
Sbjct: 237 ADTSRQASFHCKESYLPVPGRFLTSAPRGLTPVAERPAVGELEDSPQKKMQSRAWGKVEV 296

Query: 301 RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
           RPSCSGAA  G LP+G   RK+A  KKSL GA +LAL   FPA G+RLSA PP+PA+FPP
Sbjct: 297 RPSCSGAAAAGALPQGLSRRKMAGGKKSLGGASQLALGRGFPACGERLSAAPPEPATFPP 356

Query: 361 VSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
            SGV   G S +P++PKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPT +P L
Sbjct: 357 FSGVRPQGMSKKPQKPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTHRPGL 416

Query: 421 ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
             LSVRRGE+SS DPNIRAPQ+ GTS+PSA++   LVPR HA SG+ QPPVHPPRPERQQ
Sbjct: 417 PRLSVRRGEFSSSDPNIRAPQLPGTSEPSAYSPGGLVPRRHAPSGNQQPPVHPPRPERQQ 476

Query: 481 QPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL 518
           QPPGAQGCPRCI LQREIEDL  QLAAMQFLTDKFQDL
Sbjct: 477 QPPGAQGCPRCIWLQREIEDLTQQLAAMQFLTDKFQDL 514


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 1487

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 123/494 (24%), Positives = 165/494 (33%), Gaps = 106/494 (21%)

Query: 15  GPEG--GEQAGAHTASPGAPRGD-GHGRDLNFGGQR--SGKGKGKGESGFTDPESFSFES 69
           GP+G  GE+  +  A P    GD G   +    G R  +G+    G  G   P       
Sbjct: 525 GPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAP--- 581

Query: 70  ESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
                        G++GRPG P    A G                   V G P P+GA  
Sbjct: 582 -------------GEDGRPGPPGPQGARG----------------QPGVMGFPGPKGANG 612

Query: 130 KGSTDIWADLEVGPSWRGALSPSPG-EWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
           +        L   P  RG     PG + +  +AGP     PGP GPA E  E+G+     
Sbjct: 613 EPGKAGEKGLPGAPGLRGL----PGKDGETGAAGP-----PGPAGPAGERGEQGAPGPSG 663

Query: 188 FQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG--DTCG 245
           FQ  P  P   G  G                        K G Q  PG    PG     G
Sbjct: 664 FQGLPGPPGPPGEGG------------------------KPGDQGVPGEAGAPGLVGPRG 699

Query: 246 RRSFHRRESYLQVQGPLLISPPRRL--TPVVERP--AVGELDVPSLKKMQSMVWGKRGVR 301
            R F         QG   +  PR L  TP  + P  A G    P  +       G +G+ 
Sbjct: 700 ERGFPGERGSPGAQG---LQGPRGLPGTPGTDGPKGASGPAGPPGAQGPP----GLQGMP 752

Query: 302 PSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL----ALRGAFPAWGQRLSAVPPDPA 356
                A + GP   RG +G K  +     +G   L       G   A G++    PP PA
Sbjct: 753 GERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPA 812

Query: 357 SFPPVSGV-GLLGKSVRPKEPKHSSP--GKKPAGRKTRESQAAAREDNDPNRDEVPRAQL 413
                 G  G  G++  P     + P       G K  + +A  + D      + P    
Sbjct: 813 GSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAP 872

Query: 414 PTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHP 473
             Q P  ++   +    + G P         T  P A    R+ P    S+G+  PP  P
Sbjct: 873 GPQGPTGVT-GPKGARGAQGPPG-------ATGFPGA--AGRVGP--PGSNGNPGPP-GP 919

Query: 474 PRPERQQQPPGAQG 487
           P P  +  P GA+G
Sbjct: 920 PGPSGKDGPKGARG 933



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 121/493 (24%), Positives = 156/493 (31%), Gaps = 86/493 (17%)

Query: 15   GPEG-----GEQAGAHTASPGAPRGD-GHGRDLNFGGQRSGKGKGKGESGFTDPESFSFE 68
            GP G     GE+  A  A P   RGD G        G+  G+G   G  G   P   + E
Sbjct: 744  GPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGL-TGPIGPPGPAGANGE 802

Query: 69   SESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGAT 128
             + E+   G     G  G PG   +    G          PA    P    G P  +G  
Sbjct: 803  -KGEVGPPGPAGSAGARGAPGERGETGPPG----------PAGFAGPPGADGQPGAKGEQ 851

Query: 129  AKGST--DIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVP-----GPGPAWENPERG 181
             +     D  A    GPS  GA  P          GP  ++ P       GP       G
Sbjct: 852  GEAGQKGDAGAPGPQGPS--GAPGPQ---------GPTGVTGPKGARGAQGPPGATGFPG 900

Query: 182  SKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG 241
            +  R+        P   GP G +  D          P  R      +G    PG   +PG
Sbjct: 901  AAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPG 960

Query: 242  DTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAV-GELDVPSLKKMQSMVWGKRGV 300
            D          +     +GP           +V  P   GE   P L    S   GK+G 
Sbjct: 961  D----------DGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPG-PSGEPGKQGA 1009

Query: 301  RPSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
             P  SG   RGP  P G  G      +   EG+P               +  PP      
Sbjct: 1010 -PGASGD--RGPPGPVGPPGLTGPAGEPGREGSPG--------------ADGPPGRDGAA 1052

Query: 360  PVSG----VGLLGKSVRPKEPKHSSPGKK-PAGRKTRESQAAAREDNDPNRDEVPRAQLP 414
             V G     G +G    P  P   SPG   P G++    +A A+    P+     R    
Sbjct: 1053 GVKGDRGETGAVGAPGAPGPP--GSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQG 1110

Query: 415  TQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPP 474
             Q P       R  +  +G+P  R     G      FT  + +P     SGD Q    P 
Sbjct: 1111 PQGP-------RGDKGEAGEPGER-----GLKGHRGFTGLQGLPGPPGPSGD-QGASGPA 1157

Query: 475  RPERQQQPPGAQG 487
             P   + PPG  G
Sbjct: 1158 GPSGPRGPPGPVG 1170



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 67/271 (24%), Positives = 87/271 (32%), Gaps = 26/271 (9%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            R   GP G           G P  +G+       G  SGK   KG  G + P   + E  
Sbjct: 887  RGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGP-SGKDGPKGARGDSGPPGRAGEPG 945

Query: 71   SELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSS-----VQGHPSPE 125
                 QG     G++G PG      A G      LA +   +  P         G P P 
Sbjct: 946  L----QGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 1001

Query: 126  GATAK-----GSTDIWADLEVGPSWRGALSPSPG-EWQQASAGPLHLSVPG-PGPAWENP 178
            G   K      S D      VGP      +  PG E    + GP     PG  G A    
Sbjct: 1002 GEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGP-----PGRDGAAGVKG 1056

Query: 179  ERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPK 238
            +RG    +     P  P + GPAG      D  +  +  P+     +   G Q   G   
Sbjct: 1057 DRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRG 1116

Query: 239  KPGDT--CGRRSFHRRESYLQVQGPLLISPP 267
              G+    G R       +  +QG  L  PP
Sbjct: 1117 DKGEAGEPGERGLKGHRGFTGLQG--LPGPP 1145



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 46/170 (27%), Positives = 58/170 (34%), Gaps = 24/170 (14%)

Query: 83   GQEGRPGTPVDDQAGGGDYSFYLADE---------PATIMPPSSVQGHPSPEGATAKGST 133
            G+ GR G+P  D   G D +  +  +         P    PP    G P P G T K   
Sbjct: 1032 GEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPP----GSPGPAGPTGKQGD 1087

Query: 134  --DIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVD 191
              +  A   +GPS      P+     Q   GP        G A E  ERG K    F   
Sbjct: 1088 RGEAGAQGPMGPS-----GPAGARGIQGPQGPRG----DKGEAGEPGERGLKGHRGFTGL 1138

Query: 192  PQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG 241
               P   GP+G       +       P   V  S K+G+   PG    PG
Sbjct: 1139 QGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPG 1188



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 112/487 (22%), Positives = 143/487 (29%), Gaps = 129/487 (26%)

Query: 14  LGPEG--GEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           +GP+G  G Q  A    P   RGD                  KGE G   P         
Sbjct: 116 VGPKGPPGPQGPAGEQGPRGDRGD------------------KGEKGAPGPR-------- 149

Query: 72  ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
                      G++G PGTP                 P    PP    G P P G     
Sbjct: 150 -----------GRDGEPGTP---------------GNPGPPGPP----GPPGPPGLGGNF 179

Query: 132 STDIWA--DLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQ 189
           +  +    D + G +  G +        Q   GP+    P PGPA      G+     FQ
Sbjct: 180 AAQMAGGFDEKAGGAQLGVM--------QGPMGPMGPRGP-PGPA------GAPGPQGFQ 224

Query: 190 VDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSF 249
            +P +P   G +G                          G +  PG P KPGD  G    
Sbjct: 225 GNPGEPGEPGVSG------------------------PMGPRGPPGPPGKPGDD-GEAG- 258

Query: 250 HRRESYLQVQGPLLISPPRRLTPVVERPAV-GELDVPSLKKMQSMVWGKRGVRPSCSGAA 308
             +      +GP      R        P V G    P L   +    G  GV+       
Sbjct: 259 --KPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEA-GAPGVKGESGSPG 315

Query: 309 VRG-PLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGVGLL 367
             G P P G  G    + +    GA      GA    GQ   A PP P    P  G G  
Sbjct: 316 ENGSPGPMGPRGLPGERGRTGPAGA-----AGARGNDGQPGPAGPPGPVG--PAGGPGFP 368

Query: 368 GK-----SVRPKEPKHSSPGKKPAGRK-TRESQAAAREDNDPNRDEVPRAQLPTQKPELI 421
           G         P   +     + P G   T  S   A    +P  D +P A+     P + 
Sbjct: 369 GAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIA 428

Query: 422 SLSVRRGEYSSGDPNIRAPQ-VLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
                    + G P  R P    G + P     +   P      G+ Q P   P P   Q
Sbjct: 429 G--------APGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGE-QGPKGEPGPAGPQ 479

Query: 481 QPPGAQG 487
             PG  G
Sbjct: 480 GAPGPAG 486


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 123/494 (24%), Positives = 165/494 (33%), Gaps = 106/494 (21%)

Query: 15  GPEG--GEQAGAHTASPGAPRGD-GHGRDLNFGGQR--SGKGKGKGESGFTDPESFSFES 69
           GP+G  GE+  +  A P    GD G   +    G R  +G+    G  G   P       
Sbjct: 456 GPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAP--- 512

Query: 70  ESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
                        G++GRPG P    A G                   V G P P+GA  
Sbjct: 513 -------------GEDGRPGPPGPQGARG----------------QPGVMGFPGPKGANG 543

Query: 130 KGSTDIWADLEVGPSWRGALSPSPG-EWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
           +        L   P  RG     PG + +  +AGP     PGP GPA E  E+G+     
Sbjct: 544 EPGKAGEKGLPGAPGLRGL----PGKDGETGAAGP-----PGPAGPAGERGEQGAPGPSG 594

Query: 188 FQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG--DTCG 245
           FQ  P  P   G  G                        K G Q  PG    PG     G
Sbjct: 595 FQGLPGPPGPPGEGG------------------------KPGDQGVPGEAGAPGLVGPRG 630

Query: 246 RRSFHRRESYLQVQGPLLISPPRRL--TPVVERP--AVGELDVPSLKKMQSMVWGKRGVR 301
            R F         QG   +  PR L  TP  + P  A G    P  +       G +G+ 
Sbjct: 631 ERGFPGERGSPGAQG---LQGPRGLPGTPGTDGPKGASGPAGPPGAQGPP----GLQGMP 683

Query: 302 PSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL----ALRGAFPAWGQRLSAVPPDPA 356
                A + GP   RG +G K  +     +G   L       G   A G++    PP PA
Sbjct: 684 GERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPA 743

Query: 357 SFPPVSGV-GLLGKSVRPKEPKHSSP--GKKPAGRKTRESQAAAREDNDPNRDEVPRAQL 413
                 G  G  G++  P     + P       G K  + +A  + D      + P    
Sbjct: 744 GSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAP 803

Query: 414 PTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHP 473
             Q P  ++   +    + G P         T  P A    R+ P    S+G+  PP  P
Sbjct: 804 GPQGPTGVT-GPKGARGAQGPPG-------ATGFPGA--AGRVGP--PGSNGNPGPP-GP 850

Query: 474 PRPERQQQPPGAQG 487
           P P  +  P GA+G
Sbjct: 851 PGPSGKDGPKGARG 864



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 121/493 (24%), Positives = 156/493 (31%), Gaps = 86/493 (17%)

Query: 15   GPEG-----GEQAGAHTASPGAPRGD-GHGRDLNFGGQRSGKGKGKGESGFTDPESFSFE 68
            GP G     GE+  A  A P   RGD G        G+  G+G   G  G   P   + E
Sbjct: 675  GPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGL-TGPIGPPGPAGANGE 733

Query: 69   SESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGAT 128
             + E+   G     G  G PG   +    G          PA    P    G P  +G  
Sbjct: 734  -KGEVGPPGPAGSAGARGAPGERGETGPPG----------PAGFAGPPGADGQPGAKGEQ 782

Query: 129  AKGST--DIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVP-----GPGPAWENPERG 181
             +     D  A    GPS  GA  P          GP  ++ P       GP       G
Sbjct: 783  GEAGQKGDAGAPGPQGPS--GAPGPQ---------GPTGVTGPKGARGAQGPPGATGFPG 831

Query: 182  SKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG 241
            +  R+        P   GP G +  D          P  R      +G    PG   +PG
Sbjct: 832  AAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPG 891

Query: 242  DTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAV-GELDVPSLKKMQSMVWGKRGV 300
            D          +     +GP           +V  P   GE   P L    S   GK+G 
Sbjct: 892  D----------DGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPG-PSGEPGKQGA 940

Query: 301  RPSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
             P  SG   RGP  P G  G      +   EG+P               +  PP      
Sbjct: 941  -PGASGD--RGPPGPVGPPGLTGPAGEPGREGSPG--------------ADGPPGRDGAA 983

Query: 360  PVSG----VGLLGKSVRPKEPKHSSPGKK-PAGRKTRESQAAAREDNDPNRDEVPRAQLP 414
             V G     G +G    P  P   SPG   P G++    +A A+    P+     R    
Sbjct: 984  GVKGDRGETGAVGAPGAPGPP--GSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQG 1041

Query: 415  TQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPP 474
             Q P       R  +  +G+P  R     G      FT  + +P     SGD Q    P 
Sbjct: 1042 PQGP-------RGDKGEAGEPGER-----GLKGHRGFTGLQGLPGPPGPSGD-QGASGPA 1088

Query: 475  RPERQQQPPGAQG 487
             P   + PPG  G
Sbjct: 1089 GPSGPRGPPGPVG 1101



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 67/271 (24%), Positives = 87/271 (32%), Gaps = 26/271 (9%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            R   GP G           G P  +G+       G  SGK   KG  G + P   + E  
Sbjct: 818  RGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGP-SGKDGPKGARGDSGPPGRAGEPG 876

Query: 71   SELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSS-----VQGHPSPE 125
                 QG     G++G PG      A G      LA +   +  P         G P P 
Sbjct: 877  L----QGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 932

Query: 126  GATAK-----GSTDIWADLEVGPSWRGALSPSPG-EWQQASAGPLHLSVPG-PGPAWENP 178
            G   K      S D      VGP      +  PG E    + GP     PG  G A    
Sbjct: 933  GEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGP-----PGRDGAAGVKG 987

Query: 179  ERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPK 238
            +RG    +     P  P + GPAG      D  +  +  P+     +   G Q   G   
Sbjct: 988  DRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRG 1047

Query: 239  KPGDT--CGRRSFHRRESYLQVQGPLLISPP 267
              G+    G R       +  +QG  L  PP
Sbjct: 1048 DKGEAGEPGERGLKGHRGFTGLQG--LPGPP 1076



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 46/170 (27%), Positives = 58/170 (34%), Gaps = 24/170 (14%)

Query: 83   GQEGRPGTPVDDQAGGGDYSFYLADE---------PATIMPPSSVQGHPSPEGATAKGST 133
            G+ GR G+P  D   G D +  +  +         P    PP    G P P G T K   
Sbjct: 963  GEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPP----GSPGPAGPTGKQGD 1018

Query: 134  --DIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVD 191
              +  A   +GPS      P+     Q   GP        G A E  ERG K    F   
Sbjct: 1019 RGEAGAQGPMGPS-----GPAGARGIQGPQGPRG----DKGEAGEPGERGLKGHRGFTGL 1069

Query: 192  PQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG 241
               P   GP+G       +       P   V  S K+G+   PG    PG
Sbjct: 1070 QGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPG 1119



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 112/487 (22%), Positives = 143/487 (29%), Gaps = 129/487 (26%)

Query: 14  LGPEG--GEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           +GP+G  G Q  A    P   RGD                  KGE G   P         
Sbjct: 47  VGPKGPPGPQGPAGEQGPRGDRGD------------------KGEKGAPGPR-------- 80

Query: 72  ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
                      G++G PGTP                 P    PP    G P P G     
Sbjct: 81  -----------GRDGEPGTP---------------GNPGPPGPP----GPPGPPGLGGNF 110

Query: 132 STDIWA--DLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQ 189
           +  +    D + G +  G +        Q   GP+    P PGPA      G+     FQ
Sbjct: 111 AAQMAGGFDEKAGGAQLGVM--------QGPMGPMGPRGP-PGPA------GAPGPQGFQ 155

Query: 190 VDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSF 249
            +P +P   G +G                          G +  PG P KPGD  G    
Sbjct: 156 GNPGEPGEPGVSG------------------------PMGPRGPPGPPGKPGDD-GEAG- 189

Query: 250 HRRESYLQVQGPLLISPPRRLTPVVERPAV-GELDVPSLKKMQSMVWGKRGVRPSCSGAA 308
             +      +GP      R        P V G    P L   +    G  GV+       
Sbjct: 190 --KPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEA-GAPGVKGESGSPG 246

Query: 309 VRG-PLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGVGLL 367
             G P P G  G    + +    GA      GA    GQ   A PP P    P  G G  
Sbjct: 247 ENGSPGPMGPRGLPGERGRTGPAGA-----AGARGNDGQPGPAGPPGPVG--PAGGPGFP 299

Query: 368 GK-----SVRPKEPKHSSPGKKPAGRK-TRESQAAAREDNDPNRDEVPRAQLPTQKPELI 421
           G         P   +     + P G   T  S   A    +P  D +P A+     P + 
Sbjct: 300 GAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIA 359

Query: 422 SLSVRRGEYSSGDPNIRAPQ-VLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQ 480
                    + G P  R P    G + P     +   P      G+ Q P   P P   Q
Sbjct: 360 G--------APGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGE-QGPKGEPGPAGPQ 410

Query: 481 QPPGAQG 487
             PG  G
Sbjct: 411 GAPGPAG 417


>gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo
            sapiens]
          Length = 1818

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 115/447 (25%), Positives = 150/447 (33%), Gaps = 48/447 (10%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPES-FSFES---- 69
            GP G         +PG   GDG        G    KG  +G  GF  P      +     
Sbjct: 1159 GPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGD-EGARGFPGPPGPIGLQGLPGP 1217

Query: 70   ESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
              E  E G V   G  G PG P   Q   G      AD P    PP SV    S  G   
Sbjct: 1218 PGEKGENGDVGPMGPPGPPG-PRGPQGPNG------ADGPQG--PPGSVG---SVGGVGE 1265

Query: 130  KGSTDIWADLEVG----PSWRGALSPSPGEWQQASAGPLHLSVP--GPGPAWENPERGSK 183
            KG        E G    P   G   P     ++  AGP   + P    GP  ++  +G+ 
Sbjct: 1266 KGEPG-----EAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNP 1320

Query: 184  SRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT 243
              + F  DP  P   GPAG    D    D+  D    +       G    PG P K G  
Sbjct: 1321 GPVGFPGDPGPPGEPGPAG---QDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPP 1377

Query: 244  CGRRSFHRRESYLQVQGPL-LISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRP 302
             G      R+     +G      PP +  PV  +   G+     L+ +   V G++G+  
Sbjct: 1378 -GAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV-GEQGLPG 1435

Query: 303  SCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAVPPDPASFPP 360
            +       GP+ P G  G K     K  +G P L  L G     G++     P     P 
Sbjct: 1436 AAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPG 1495

Query: 361  VSGVGLLGKSVRPKEPKHSSPG----KKPAGRKTRESQAAAREDN---DPNRDEVPRAQL 413
              G G +     P  P    PG    + P G K     A  + D+    P     P  ++
Sbjct: 1496 AKGDGGIPGPAGPLGPP-GPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEV 1554

Query: 414  PTQKPELISLSVRR---GEYSSGDPNI 437
                P L S   RR   G  +  D NI
Sbjct: 1555 IQPLPILSSKKTRRHTEGMQADADDNI 1581



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 53/208 (25%), Positives = 75/208 (36%), Gaps = 30/208 (14%)

Query: 15  GPEGGEQAGAHTASPGA---PRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           GP G +     T  PG    P  DG       G    G+   KG+ GF        +   
Sbjct: 574 GPRGVQGPPGPTGKPGKRGRPGADG-------GRGMPGEPGAKGDRGFDGLPGLPGD--- 623

Query: 72  ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
               +G     G +G PG P DD   G D        P  +   +  +G   P G     
Sbjct: 624 ----KGHRGERGPQGPPGPPGDDGMRGEDGEI----GPRGLPGEAGPRGLLGPRGTPGAP 675

Query: 132 STDIWADLEVGPSWRGALSP--SPG-EWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
                A ++  P  +G + P   PG   QQ + GP  L  PGP GP     E+G + +  
Sbjct: 676 GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL--PGPQGPIGPPGEKGPQGKPG 733

Query: 188 FQVDPQQPSAEGPAGLNTDDSDSADESS 215
                  P A+GP G    +  S ++ +
Sbjct: 734 L---AGLPGADGPPGHPGKEGQSGEKGA 758



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 129/533 (24%), Positives = 177/533 (33%), Gaps = 95/533 (17%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            +  LGP G +    +    G    DG        G +  KG+ KGE GF   +      +
Sbjct: 756  KGALGPPGPQGPIGYPGPRGVKGADG------VRGLKGSKGE-KGEDGFPGFKG-DMGLK 807

Query: 71   SELIEQGRVVLWGQEGRPGT-----PVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPE 125
             +  E G++   G++G  G      P  D    G      A E   +  P  + G+P  +
Sbjct: 808  GDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQ-----AGEKGKLGVPG-LPGYPGRQ 861

Query: 126  GATAKGSTDI----WADLEVG-------PSWRGALSPSPGEWQQASAGPLHLSVPG---- 170
            G   KGST       A+ E G       P  RG   P+     + + GP     P     
Sbjct: 862  GP--KGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSG 919

Query: 171  ----PGPAWENPERGSKSRLSF---QVDPQQPSAEGPAGLNTDDSDSADESSDLP----- 218
                PGP  E   +G +  + F   +  P  P  +G  G      ++  +    P     
Sbjct: 920  GDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGG 979

Query: 219  VIRVIISTKE----GSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVV 274
            V+     T E    G +  PG P  PG+  G      +E      GP  IS   +  P  
Sbjct: 980  VVGPQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKGDPGPQGISG--KDGPAG 1036

Query: 275  ERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRG---TLGRKVAQEKKSLEG 331
             R   GE  +P  +    +   K G  P      V  P  RG   T G      +   +G
Sbjct: 1037 LRGFPGERGLPGAQGAPGL---KGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQG 1093

Query: 332  APELALRGAFPAWGQRLSAVPPDPASFPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKT 390
             P  A  G   A G++    P  PA    V G VGL G    P  P  S       G   
Sbjct: 1094 PPGPA--GEKGAPGEK---GPQGPAGRDGVQGPVGLPG----PAGPAGSPGEDGDKGEIG 1144

Query: 391  RESQAAAREDNDPNRDEVPRA-QLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQ-- 447
               Q  ++ D   N    P   Q P   P +            G+P  R  Q +   +  
Sbjct: 1145 EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG--------GDGEPGPRGQQGMFGQKGD 1196

Query: 448  ---------PSAFTLRRLV--PRCHASSGDWQP--PVHPPRPERQQQPPGAQG 487
                     P    L+ L   P     +GD  P  P  PP P   Q P GA G
Sbjct: 1197 EGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADG 1249


>gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo
            sapiens]
          Length = 1767

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 115/447 (25%), Positives = 150/447 (33%), Gaps = 48/447 (10%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPES-FSFES---- 69
            GP G         +PG   GDG        G    KG  +G  GF  P      +     
Sbjct: 1108 GPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGD-EGARGFPGPPGPIGLQGLPGP 1166

Query: 70   ESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
              E  E G V   G  G PG P   Q   G      AD P    PP SV    S  G   
Sbjct: 1167 PGEKGENGDVGPMGPPGPPG-PRGPQGPNG------ADGPQG--PPGSVG---SVGGVGE 1214

Query: 130  KGSTDIWADLEVG----PSWRGALSPSPGEWQQASAGPLHLSVP--GPGPAWENPERGSK 183
            KG        E G    P   G   P     ++  AGP   + P    GP  ++  +G+ 
Sbjct: 1215 KGEPG-----EAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNP 1269

Query: 184  SRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT 243
              + F  DP  P   GPAG    D    D+  D    +       G    PG P K G  
Sbjct: 1270 GPVGFPGDPGPPGEPGPAG---QDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPP 1326

Query: 244  CGRRSFHRRESYLQVQGPL-LISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRP 302
             G      R+     +G      PP +  PV  +   G+     L+ +   V G++G+  
Sbjct: 1327 -GAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV-GEQGLPG 1384

Query: 303  SCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAVPPDPASFPP 360
            +       GP+ P G  G K     K  +G P L  L G     G++     P     P 
Sbjct: 1385 AAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPG 1444

Query: 361  VSGVGLLGKSVRPKEPKHSSPG----KKPAGRKTRESQAAAREDN---DPNRDEVPRAQL 413
              G G +     P  P    PG    + P G K     A  + D+    P     P  ++
Sbjct: 1445 AKGDGGIPGPAGPLGPP-GPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEV 1503

Query: 414  PTQKPELISLSVRR---GEYSSGDPNI 437
                P L S   RR   G  +  D NI
Sbjct: 1504 IQPLPILSSKKTRRHTEGMQADADDNI 1530



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 53/208 (25%), Positives = 75/208 (36%), Gaps = 30/208 (14%)

Query: 15  GPEGGEQAGAHTASPGA---PRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           GP G +     T  PG    P  DG       G    G+   KG+ GF        +   
Sbjct: 523 GPRGVQGPPGPTGKPGKRGRPGADG-------GRGMPGEPGAKGDRGFDGLPGLPGD--- 572

Query: 72  ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
               +G     G +G PG P DD   G D        P  +   +  +G   P G     
Sbjct: 573 ----KGHRGERGPQGPPGPPGDDGMRGEDGEI----GPRGLPGEAGPRGLLGPRGTPGAP 624

Query: 132 STDIWADLEVGPSWRGALSP--SPG-EWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
                A ++  P  +G + P   PG   QQ + GP  L  PGP GP     E+G + +  
Sbjct: 625 GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL--PGPQGPIGPPGEKGPQGKPG 682

Query: 188 FQVDPQQPSAEGPAGLNTDDSDSADESS 215
                  P A+GP G    +  S ++ +
Sbjct: 683 L---AGLPGADGPPGHPGKEGQSGEKGA 707



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 129/533 (24%), Positives = 177/533 (33%), Gaps = 95/533 (17%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            +  LGP G +    +    G    DG        G +  KG+ KGE GF   +      +
Sbjct: 705  KGALGPPGPQGPIGYPGPRGVKGADG------VRGLKGSKGE-KGEDGFPGFKG-DMGLK 756

Query: 71   SELIEQGRVVLWGQEGRPGT-----PVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPE 125
             +  E G++   G++G  G      P  D    G      A E   +  P  + G+P  +
Sbjct: 757  GDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQ-----AGEKGKLGVPG-LPGYPGRQ 810

Query: 126  GATAKGSTDI----WADLEVG-------PSWRGALSPSPGEWQQASAGPLHLSVPG---- 170
            G   KGST       A+ E G       P  RG   P+     + + GP     P     
Sbjct: 811  GP--KGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSG 868

Query: 171  ----PGPAWENPERGSKSRLSF---QVDPQQPSAEGPAGLNTDDSDSADESSDLP----- 218
                PGP  E   +G +  + F   +  P  P  +G  G      ++  +    P     
Sbjct: 869  GDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGG 928

Query: 219  VIRVIISTKE----GSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVV 274
            V+     T E    G +  PG P  PG+  G      +E      GP  IS   +  P  
Sbjct: 929  VVGPQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKGDPGPQGISG--KDGPAG 985

Query: 275  ERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRG---TLGRKVAQEKKSLEG 331
             R   GE  +P  +    +   K G  P      V  P  RG   T G      +   +G
Sbjct: 986  LRGFPGERGLPGAQGAPGL---KGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQG 1042

Query: 332  APELALRGAFPAWGQRLSAVPPDPASFPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKT 390
             P  A  G   A G++    P  PA    V G VGL G    P  P  S       G   
Sbjct: 1043 PPGPA--GEKGAPGEK---GPQGPAGRDGVQGPVGLPG----PAGPAGSPGEDGDKGEIG 1093

Query: 391  RESQAAAREDNDPNRDEVPRA-QLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQ-- 447
               Q  ++ D   N    P   Q P   P +            G+P  R  Q +   +  
Sbjct: 1094 EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG--------GDGEPGPRGQQGMFGQKGD 1145

Query: 448  ---------PSAFTLRRLV--PRCHASSGDWQP--PVHPPRPERQQQPPGAQG 487
                     P    L+ L   P     +GD  P  P  PP P   Q P GA G
Sbjct: 1146 EGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADG 1198


>gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo
            sapiens]
          Length = 1806

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 115/447 (25%), Positives = 150/447 (33%), Gaps = 48/447 (10%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPES-FSFES---- 69
            GP G         +PG   GDG        G    KG  +G  GF  P      +     
Sbjct: 1147 GPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGD-EGARGFPGPPGPIGLQGLPGP 1205

Query: 70   ESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
              E  E G V   G  G PG P   Q   G      AD P    PP SV    S  G   
Sbjct: 1206 PGEKGENGDVGPMGPPGPPG-PRGPQGPNG------ADGPQG--PPGSVG---SVGGVGE 1253

Query: 130  KGSTDIWADLEVG----PSWRGALSPSPGEWQQASAGPLHLSVP--GPGPAWENPERGSK 183
            KG        E G    P   G   P     ++  AGP   + P    GP  ++  +G+ 
Sbjct: 1254 KGEPG-----EAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNP 1308

Query: 184  SRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT 243
              + F  DP  P   GPAG    D    D+  D    +       G    PG P K G  
Sbjct: 1309 GPVGFPGDPGPPGEPGPAG---QDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPP 1365

Query: 244  CGRRSFHRRESYLQVQGPL-LISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRP 302
             G      R+     +G      PP +  PV  +   G+     L+ +   V G++G+  
Sbjct: 1366 -GAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV-GEQGLPG 1423

Query: 303  SCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAVPPDPASFPP 360
            +       GP+ P G  G K     K  +G P L  L G     G++     P     P 
Sbjct: 1424 AAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPG 1483

Query: 361  VSGVGLLGKSVRPKEPKHSSPG----KKPAGRKTRESQAAAREDN---DPNRDEVPRAQL 413
              G G +     P  P    PG    + P G K     A  + D+    P     P  ++
Sbjct: 1484 AKGDGGIPGPAGPLGPP-GPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEV 1542

Query: 414  PTQKPELISLSVRR---GEYSSGDPNI 437
                P L S   RR   G  +  D NI
Sbjct: 1543 IQPLPILSSKKTRRHTEGMQADADDNI 1569



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 53/208 (25%), Positives = 75/208 (36%), Gaps = 30/208 (14%)

Query: 15  GPEGGEQAGAHTASPGA---PRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           GP G +     T  PG    P  DG       G    G+   KG+ GF        +   
Sbjct: 562 GPRGVQGPPGPTGKPGKRGRPGADG-------GRGMPGEPGAKGDRGFDGLPGLPGD--- 611

Query: 72  ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
               +G     G +G PG P DD   G D        P  +   +  +G   P G     
Sbjct: 612 ----KGHRGERGPQGPPGPPGDDGMRGEDGEI----GPRGLPGEAGPRGLLGPRGTPGAP 663

Query: 132 STDIWADLEVGPSWRGALSP--SPG-EWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
                A ++  P  +G + P   PG   QQ + GP  L  PGP GP     E+G + +  
Sbjct: 664 GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL--PGPQGPIGPPGEKGPQGKPG 721

Query: 188 FQVDPQQPSAEGPAGLNTDDSDSADESS 215
                  P A+GP G    +  S ++ +
Sbjct: 722 L---AGLPGADGPPGHPGKEGQSGEKGA 746



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 129/533 (24%), Positives = 177/533 (33%), Gaps = 95/533 (17%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            +  LGP G +    +    G    DG        G +  KG+ KGE GF   +      +
Sbjct: 744  KGALGPPGPQGPIGYPGPRGVKGADG------VRGLKGSKGE-KGEDGFPGFKG-DMGLK 795

Query: 71   SELIEQGRVVLWGQEGRPGT-----PVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPE 125
             +  E G++   G++G  G      P  D    G      A E   +  P  + G+P  +
Sbjct: 796  GDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQ-----AGEKGKLGVPG-LPGYPGRQ 849

Query: 126  GATAKGSTDI----WADLEVG-------PSWRGALSPSPGEWQQASAGPLHLSVPG---- 170
            G   KGST       A+ E G       P  RG   P+     + + GP     P     
Sbjct: 850  GP--KGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSG 907

Query: 171  ----PGPAWENPERGSKSRLSF---QVDPQQPSAEGPAGLNTDDSDSADESSDLP----- 218
                PGP  E   +G +  + F   +  P  P  +G  G      ++  +    P     
Sbjct: 908  GDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGG 967

Query: 219  VIRVIISTKE----GSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVV 274
            V+     T E    G +  PG P  PG+  G      +E      GP  IS   +  P  
Sbjct: 968  VVGPQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKGDPGPQGISG--KDGPAG 1024

Query: 275  ERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRG---TLGRKVAQEKKSLEG 331
             R   GE  +P  +    +   K G  P      V  P  RG   T G      +   +G
Sbjct: 1025 LRGFPGERGLPGAQGAPGL---KGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQG 1081

Query: 332  APELALRGAFPAWGQRLSAVPPDPASFPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKT 390
             P  A  G   A G++    P  PA    V G VGL G    P  P  S       G   
Sbjct: 1082 PPGPA--GEKGAPGEK---GPQGPAGRDGVQGPVGLPG----PAGPAGSPGEDGDKGEIG 1132

Query: 391  RESQAAAREDNDPNRDEVPRA-QLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQ-- 447
               Q  ++ D   N    P   Q P   P +            G+P  R  Q +   +  
Sbjct: 1133 EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG--------GDGEPGPRGQQGMFGQKGD 1184

Query: 448  ---------PSAFTLRRLV--PRCHASSGDWQP--PVHPPRPERQQQPPGAQG 487
                     P    L+ L   P     +GD  P  P  PP P   Q P GA G
Sbjct: 1185 EGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADG 1237


>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
          Length = 1838

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 104/425 (24%), Positives = 149/425 (35%), Gaps = 58/425 (13%)

Query: 15   GPEG--GEQAGAHTASPGAPRG----DGHGRDLNFGGQRSGKGKGKGESGFTDP------ 62
            GP G  G Q       P  P G    DG   ++   GQ+  KG  KGE G   P      
Sbjct: 1129 GPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGD-KGEQGPPGPTGPQGP 1187

Query: 63   --ESFSFESESELIEQGRVVLWGQEGRPGT-----------------PVDDQAGGGDYSF 103
              +     ++ E   +G+  L+GQ+G  G                  P  ++   GD   
Sbjct: 1188 IGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQ 1247

Query: 104  YLADEPATIMPPSSVQGHPSPEGATAKGSTDIWADLEVG----------PSWRGALSPSP 153
                 P     PS   G   P+G    G  +  A  E G          P   G   P  
Sbjct: 1248 MGPPGPPGPRGPSGAPGADGPQGPPG-GIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKG 1306

Query: 154  GEWQQASAGPLHLS-VPGP-GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSA 211
               ++  +GP   +  PGP GP  ++  +GS   + F  DP  P   GPAG +    D  
Sbjct: 1307 ERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKG 1366

Query: 212  DESSDLPVIRVIISTKEGSQAKPG--SPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRR 269
            D+           + + G    PG   P  P    GR+     +    ++G     PP +
Sbjct: 1367 DDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEG-----PPGK 1421

Query: 270  LTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPL-PRGTLGRKVAQEKKS 328
              P+  + A G+     L+ +   V G++G+  S       GP+ P G  G K     K 
Sbjct: 1422 TGPIGPQGAPGKPGPDGLRGIPGPV-GEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKG 1480

Query: 329  LEGAPEL-ALRGAFPAWGQRLSAVPPDP-ASFPPVSGVGLLGKS--VRPKEPKHSSPGKK 384
             +G P L  L G     G++     P P  S  P    G+ G S  + P  P        
Sbjct: 1481 EKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLPGPPG 1540

Query: 385  PAGRK 389
            P G K
Sbjct: 1541 PKGAK 1545



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 123/510 (24%), Positives = 169/510 (33%), Gaps = 135/510 (26%)

Query: 53  GKGESGFTDPESFSFESESE-LIEQGRVVL------WGQEGRPGTPVDDQAGGGDYSFYL 105
           G G++G   P   + ES+++ +++Q R+ L       G  GRPG PV     GG     L
Sbjct: 528 GGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGLTGRPG-PVGPPGSGG-----L 581

Query: 106 ADEPATIMP--PSSVQGHPSPEGATAK---GSTDIWADL--EVGPSW-RG--ALSPSPGE 155
             EP  + P  P  VQG P P G   +     +D    +  + GP   RG   L+  PGE
Sbjct: 582 KGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGE 641

Query: 156 -WQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQPSA------EGPAGLNTDDS 208
              +   GP   S P PGP  ++ ERG    +  +  P +P        +GP G      
Sbjct: 642 KGHRGDPGP---SGP-PGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPG 697

Query: 209 DSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPR 268
            +  +    P   V      G Q +PG P + G+                QG  L  P  
Sbjct: 698 VTGMDGQPGPKGNV------GPQGEPGPPGQQGNP-------------GAQG--LPGPQG 736

Query: 269 RLTPVVERPAVGELDVPSLKKMQSMVW--GKRGVRPSCSGAAVRGPL-------PRGTLG 319
            + P  E+  +G+  +P +          GK G      G    GP        PRG  G
Sbjct: 737 AIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKG 796

Query: 320 R------KVAQEKKSLEGAPELALRGAFPAWGQRLSAVPP-------------------D 354
                  K  + +K  +G P    +G     G R    PP                   D
Sbjct: 797 ADGIRGLKGTKGEKGEDGFP--GFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGD 854

Query: 355 PASFPPVSGVGLLGKSVRPKEPKHSSP-------------GKKPAGRKT--RESQAAARE 399
           P    P    G LG    P  P    P             G+K  GR T  +      R 
Sbjct: 855 PGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEK-GGRGTPGKPGPRGQRG 913

Query: 400 DNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPR 459
              P  +  PR       P+  S     G+  +G P  R P   G   P+ F        
Sbjct: 914 PTGPRGERGPRGITGKPGPKGNS----GGDGPAGPPGERGPN--GPQGPTGF-------- 959

Query: 460 CHASSGDWQPPVHPPRPERQQQPPGAQGCP 489
                         P P+    PPG  G P
Sbjct: 960 --------------PGPKGPPGPPGKDGLP 975



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 62/204 (30%), Positives = 75/204 (36%), Gaps = 27/204 (13%)

Query: 15  GPEGGEQAGAHTASPG-----APRG-DGHGRDLNFGGQR--SGKGKGKGESGFTDPESF- 65
           GP G   +G     PG      PRG  G        G+R  +G    +G  G T P+   
Sbjct: 571 GPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDR 630

Query: 66  SFESESELI-EQGRVVLWGQEGRPGTPVDDQAGGGDYSFY---LADEPAT--IMPPSSVQ 119
            F+  + L  E+G     G  G PG P DD   G D       L  EP    ++ P    
Sbjct: 631 GFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPP 690

Query: 120 GHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGE-WQQASAGPLHLSVPGPGPAWENP 178
           G P P G T         D + GP         PG   QQ + G   L  PGP  A   P
Sbjct: 691 GPPGPPGVTGM-------DGQPGPKGNVGPQGEPGPPGQQGNPGAQGL--PGPQGAIGPP 741

Query: 179 ERGSKSRLSFQVDPQQPSAEGPAG 202
             G K  L     P  P A+GP G
Sbjct: 742 --GEKGPLGKPGLPGMPGADGPPG 763


>gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein [Homo
            sapiens]
          Length = 1650

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 131/526 (24%), Positives = 172/526 (32%), Gaps = 91/526 (17%)

Query: 14   LGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGK--GESGFTDPESFSFESES 71
            +GP G   A      PGA    GH       G R   G     G  G   P         
Sbjct: 1027 IGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSG------- 1079

Query: 72   ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQ--GHPSPEGATA 129
               E+G     G  G PG P      G +     AD P    PP  V   G P  +G   
Sbjct: 1080 ---EKGETGDVGPMGPPGPPGPRGPAGPNG----ADGPQG--PPGGVGNLGPPGEKGEPG 1130

Query: 130  K-GSTDIWADLEV-GPSWRGALSPSPGEWQQASAGPLHLSVPGP-GPAWENPERGSKSRL 186
            + GS  I  +  V GP  RG         Q    GP     PGP GP  ++  +G+   +
Sbjct: 1131 ESGSPGIQGEPGVKGP--RGERGEKGESGQPGEPGP-----PGPKGPTGDDGPKGNPGPV 1183

Query: 187  SFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT--- 243
             F  DP  P   GP G    D    D   D            G   +PGSP   G+    
Sbjct: 1184 GFPGDPGPPGEGGPRG---QDGAKGDRGED------------GEPGQPGSPGPTGENGPP 1228

Query: 244  --------CGRRSFHRRESYLQVQG-PLLISPPRRLTPVVERPAVGELDVPSLKKMQSMV 294
                     G      R+     +G P  I  P +  PV      G+     L+ +   V
Sbjct: 1229 GPLGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSV 1288

Query: 295  WGKRGVRPSCSG-AAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAV 351
             G++G RP  +G A   GP+ P G  G +     K  +G P L  L G     G++    
Sbjct: 1289 -GQQG-RPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRG 1346

Query: 352  PPDPASFPPVSG-VGLLGKS-----------VRPKEPKHSSPGKKPAGRKTRESQAAARE 399
             P P   P   G +G+ G S             P  PK +     P G K  +       
Sbjct: 1347 LPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPG 1406

Query: 400  DNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGD---PNIRAPQVLGTSQP---SAFTL 453
               P  + +    LP Q P+    SV        D   P   AP   G  +    S  +L
Sbjct: 1407 HPGPPGEVI--QPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1464

Query: 454  RRLVPRCHASSGDWQPPV---------HPPRPERQQQPPGAQGCPR 490
            R  + +    +G    P          HP  P+ +      QGC R
Sbjct: 1465 REEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1510



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/229 (27%), Positives = 77/229 (33%), Gaps = 35/229 (15%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
           GP G          PG+P   G   DL   G R       G  G T P         +  
Sbjct: 404 GPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPR-------GPQGLTGPPG-------KAG 449

Query: 75  EQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGSTD 134
            +GR    G  G PG P      G D    L  E       +  QG P P G   +   D
Sbjct: 450 RRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGH-RGDTGAQGLPGPPGEDGERGDD 508

Query: 135 IWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQ 194
                E+GP  RG    S         GP  +  P PG    +  +G K  L  Q +P  
Sbjct: 509 G----EIGP--RGLPGESGPRGLLGPKGPPGIPGP-PGVRGMDGPQGPKGSLGPQGEPGP 561

Query: 195 PSAEGPAGLNTDDSDSADESSDLPVIRVIIST--KEGSQAKPGSPKKPG 241
           P  +G  G           +  LP  +  I    ++G Q KPG P  PG
Sbjct: 562 PGQQGTPG-----------TQGLPGPQGAIGPHGEKGPQGKPGLPGMPG 599



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 102/402 (25%), Positives = 129/402 (32%), Gaps = 72/402 (17%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--KGESGFTDPESFSFESESE 72
            GPEG +     T  PG P   G    L   G     G+   KG  GF      S E  + 
Sbjct: 683  GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGAR 742

Query: 73   LI--------EQGRVVLWGQEGRPGTPVDDQA---GGGDYSFYLADEPATIMPPSSVQGH 121
             +        E+G     GQ G  G      A    GGD       E   +  P    G 
Sbjct: 743  GLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG-LPGPQGPNGF 801

Query: 122  PSPEGATAKGSTDIWADLEVGPSWRGALS-------PSPG-----EWQQASAGPL-HLSV 168
            P P+G       D    L   P  RG +        P P      +      GP+     
Sbjct: 802  PGPKGPPGPPGKD---GLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGH 858

Query: 169  PGP-GPAWENPERGSKSRLSFQVDPQQPSA---EGPAGLNTDDSD-SADESSDLPVIRVI 223
            PGP GP  E    G+  +   + DP  P A   +GPAGL     +     ++  P ++  
Sbjct: 859  PGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLK-- 916

Query: 224  ISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELD 283
                EG    PG    PG+     S           GP  I PP R  P     A GE  
Sbjct: 917  --GNEGPSGPPGPAGSPGERGAAGS----------GGP--IGPPGRPGPQGPPGAAGEKG 962

Query: 284  VPSLKKMQSMVWGKRGVRPSCSGAAVRGPL----PRGTLGRKVAQEKKSLEGAPELALRG 339
            VP          G++G         V+GP+    P G  G       K   G P     G
Sbjct: 963  VP----------GEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDP-----G 1007

Query: 340  AFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKHSSP 381
                 G +    PP P    P+  VG  G +    EP    P
Sbjct: 1008 QKGTKGNKGEHGPPGPPG--PIGPVGQPGAAGADGEPGARGP 1047


>gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein [Homo
            sapiens]
          Length = 1629

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 131/526 (24%), Positives = 172/526 (32%), Gaps = 91/526 (17%)

Query: 14   LGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGK--GESGFTDPESFSFESES 71
            +GP G   A      PGA    GH       G R   G     G  G   P         
Sbjct: 1006 IGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSG------- 1058

Query: 72   ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQ--GHPSPEGATA 129
               E+G     G  G PG P      G +     AD P    PP  V   G P  +G   
Sbjct: 1059 ---EKGETGDVGPMGPPGPPGPRGPAGPNG----ADGPQG--PPGGVGNLGPPGEKGEPG 1109

Query: 130  K-GSTDIWADLEV-GPSWRGALSPSPGEWQQASAGPLHLSVPGP-GPAWENPERGSKSRL 186
            + GS  I  +  V GP  RG         Q    GP     PGP GP  ++  +G+   +
Sbjct: 1110 ESGSPGIQGEPGVKGP--RGERGEKGESGQPGEPGP-----PGPKGPTGDDGPKGNPGPV 1162

Query: 187  SFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT--- 243
             F  DP  P   GP G    D    D   D            G   +PGSP   G+    
Sbjct: 1163 GFPGDPGPPGEGGPRG---QDGAKGDRGED------------GEPGQPGSPGPTGENGPP 1207

Query: 244  --------CGRRSFHRRESYLQVQG-PLLISPPRRLTPVVERPAVGELDVPSLKKMQSMV 294
                     G      R+     +G P  I  P +  PV      G+     L+ +   V
Sbjct: 1208 GPLGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSV 1267

Query: 295  WGKRGVRPSCSG-AAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAV 351
             G++G RP  +G A   GP+ P G  G +     K  +G P L  L G     G++    
Sbjct: 1268 -GQQG-RPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRG 1325

Query: 352  PPDPASFPPVSG-VGLLGKS-----------VRPKEPKHSSPGKKPAGRKTRESQAAARE 399
             P P   P   G +G+ G S             P  PK +     P G K  +       
Sbjct: 1326 LPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPG 1385

Query: 400  DNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGD---PNIRAPQVLGTSQP---SAFTL 453
               P  + +    LP Q P+    SV        D   P   AP   G  +    S  +L
Sbjct: 1386 HPGPPGEVI--QPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1443

Query: 454  RRLVPRCHASSGDWQPPV---------HPPRPERQQQPPGAQGCPR 490
            R  + +    +G    P          HP  P+ +      QGC R
Sbjct: 1444 REEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1489



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/229 (27%), Positives = 77/229 (33%), Gaps = 35/229 (15%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
           GP G          PG+P   G   DL   G R       G  G T P         +  
Sbjct: 383 GPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPR-------GPQGLTGPPG-------KAG 428

Query: 75  EQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGSTD 134
            +GR    G  G PG P      G D    L  E       +  QG P P G   +   D
Sbjct: 429 RRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGH-RGDTGAQGLPGPPGEDGERGDD 487

Query: 135 IWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQ 194
                E+GP  RG    S         GP  +  P PG    +  +G K  L  Q +P  
Sbjct: 488 G----EIGP--RGLPGESGPRGLLGPKGPPGIPGP-PGVRGMDGPQGPKGSLGPQGEPGP 540

Query: 195 PSAEGPAGLNTDDSDSADESSDLPVIRVIIST--KEGSQAKPGSPKKPG 241
           P  +G  G           +  LP  +  I    ++G Q KPG P  PG
Sbjct: 541 PGQQGTPG-----------TQGLPGPQGAIGPHGEKGPQGKPGLPGMPG 578



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 102/402 (25%), Positives = 129/402 (32%), Gaps = 72/402 (17%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--KGESGFTDPESFSFESESE 72
            GPEG +     T  PG P   G    L   G     G+   KG  GF      S E  + 
Sbjct: 662  GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGAR 721

Query: 73   LI--------EQGRVVLWGQEGRPGTPVDDQA---GGGDYSFYLADEPATIMPPSSVQGH 121
             +        E+G     GQ G  G      A    GGD       E   +  P    G 
Sbjct: 722  GLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG-LPGPQGPNGF 780

Query: 122  PSPEGATAKGSTDIWADLEVGPSWRGALS-------PSPG-----EWQQASAGPL-HLSV 168
            P P+G       D    L   P  RG +        P P      +      GP+     
Sbjct: 781  PGPKGPPGPPGKD---GLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGH 837

Query: 169  PGP-GPAWENPERGSKSRLSFQVDPQQPSA---EGPAGLNTDDSD-SADESSDLPVIRVI 223
            PGP GP  E    G+  +   + DP  P A   +GPAGL     +     ++  P ++  
Sbjct: 838  PGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLK-- 895

Query: 224  ISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELD 283
                EG    PG    PG+     S           GP  I PP R  P     A GE  
Sbjct: 896  --GNEGPSGPPGPAGSPGERGAAGS----------GGP--IGPPGRPGPQGPPGAAGEKG 941

Query: 284  VPSLKKMQSMVWGKRGVRPSCSGAAVRGPL----PRGTLGRKVAQEKKSLEGAPELALRG 339
            VP          G++G         V+GP+    P G  G       K   G P     G
Sbjct: 942  VP----------GEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDP-----G 986

Query: 340  AFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKHSSP 381
                 G +    PP P    P+  VG  G +    EP    P
Sbjct: 987  QKGTKGNKGEHGPPGPPG--PIGPVGQPGAAGADGEPGARGP 1026


>gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein [Homo
            sapiens]
          Length = 1736

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 131/526 (24%), Positives = 172/526 (32%), Gaps = 91/526 (17%)

Query: 14   LGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGK--GESGFTDPESFSFESES 71
            +GP G   A      PGA    GH       G R   G     G  G   P         
Sbjct: 1113 IGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSG------- 1165

Query: 72   ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQ--GHPSPEGATA 129
               E+G     G  G PG P      G +     AD P    PP  V   G P  +G   
Sbjct: 1166 ---EKGETGDVGPMGPPGPPGPRGPAGPNG----ADGPQG--PPGGVGNLGPPGEKGEPG 1216

Query: 130  K-GSTDIWADLEV-GPSWRGALSPSPGEWQQASAGPLHLSVPGP-GPAWENPERGSKSRL 186
            + GS  I  +  V GP  RG         Q    GP     PGP GP  ++  +G+   +
Sbjct: 1217 ESGSPGIQGEPGVKGP--RGERGEKGESGQPGEPGP-----PGPKGPTGDDGPKGNPGPV 1269

Query: 187  SFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDT--- 243
             F  DP  P   GP G    D    D   D            G   +PGSP   G+    
Sbjct: 1270 GFPGDPGPPGEGGPRG---QDGAKGDRGED------------GEPGQPGSPGPTGENGPP 1314

Query: 244  --------CGRRSFHRRESYLQVQG-PLLISPPRRLTPVVERPAVGELDVPSLKKMQSMV 294
                     G      R+     +G P  I  P +  PV      G+     L+ +   V
Sbjct: 1315 GPLGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSV 1374

Query: 295  WGKRGVRPSCSG-AAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-ALRGAFPAWGQRLSAV 351
             G++G RP  +G A   GP+ P G  G +     K  +G P L  L G     G++    
Sbjct: 1375 -GQQG-RPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRG 1432

Query: 352  PPDPASFPPVSG-VGLLGKS-----------VRPKEPKHSSPGKKPAGRKTRESQAAARE 399
             P P   P   G +G+ G S             P  PK +     P G K  +       
Sbjct: 1433 LPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPG 1492

Query: 400  DNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGD---PNIRAPQVLGTSQP---SAFTL 453
               P  + +    LP Q P+    SV        D   P   AP   G  +    S  +L
Sbjct: 1493 HPGPPGEVI--QPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1550

Query: 454  RRLVPRCHASSGDWQPPV---------HPPRPERQQQPPGAQGCPR 490
            R  + +    +G    P          HP  P+ +      QGC R
Sbjct: 1551 REEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1596



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/229 (27%), Positives = 77/229 (33%), Gaps = 35/229 (15%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
           GP G          PG+P   G   DL   G R       G  G T P         +  
Sbjct: 490 GPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPR-------GPQGLTGPPG-------KAG 535

Query: 75  EQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGSTD 134
            +GR    G  G PG P      G D    L  E       +  QG P P G   +   D
Sbjct: 536 RRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGH-RGDTGAQGLPGPPGEDGERGDD 594

Query: 135 IWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQ 194
                E+GP  RG    S         GP  +  P PG    +  +G K  L  Q +P  
Sbjct: 595 G----EIGP--RGLPGESGPRGLLGPKGPPGIPGP-PGVRGMDGPQGPKGSLGPQGEPGP 647

Query: 195 PSAEGPAGLNTDDSDSADESSDLPVIRVIIST--KEGSQAKPGSPKKPG 241
           P  +G  G           +  LP  +  I    ++G Q KPG P  PG
Sbjct: 648 PGQQGTPG-----------TQGLPGPQGAIGPHGEKGPQGKPGLPGMPG 685



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 102/402 (25%), Positives = 129/402 (32%), Gaps = 72/402 (17%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--KGESGFTDPESFSFESESE 72
            GPEG +     T  PG P   G    L   G     G+   KG  GF      S E  + 
Sbjct: 769  GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGAR 828

Query: 73   LI--------EQGRVVLWGQEGRPGTPVDDQA---GGGDYSFYLADEPATIMPPSSVQGH 121
             +        E+G     GQ G  G      A    GGD       E   +  P    G 
Sbjct: 829  GLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG-LPGPQGPNGF 887

Query: 122  PSPEGATAKGSTDIWADLEVGPSWRGALS-------PSPG-----EWQQASAGPL-HLSV 168
            P P+G       D    L   P  RG +        P P      +      GP+     
Sbjct: 888  PGPKGPPGPPGKD---GLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGH 944

Query: 169  PGP-GPAWENPERGSKSRLSFQVDPQQPSA---EGPAGLNTDDSD-SADESSDLPVIRVI 223
            PGP GP  E    G+  +   + DP  P A   +GPAGL     +     ++  P ++  
Sbjct: 945  PGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLK-- 1002

Query: 224  ISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELD 283
                EG    PG    PG+     S           GP  I PP R  P     A GE  
Sbjct: 1003 --GNEGPSGPPGPAGSPGERGAAGS----------GGP--IGPPGRPGPQGPPGAAGEKG 1048

Query: 284  VPSLKKMQSMVWGKRGVRPSCSGAAVRGPL----PRGTLGRKVAQEKKSLEGAPELALRG 339
            VP          G++G         V+GP+    P G  G       K   G P     G
Sbjct: 1049 VP----------GEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDP-----G 1093

Query: 340  AFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKHSSP 381
                 G +    PP P    P+  VG  G +    EP    P
Sbjct: 1094 QKGTKGNKGEHGPPGPPG--PIGPVGQPGAAGADGEPGARGP 1133


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 97/420 (23%), Positives = 144/420 (34%), Gaps = 88/420 (20%)

Query: 12  AGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE- 70
           +G  P    +  A+T        +G         +      G+ +S   D  S S E++ 
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV 212

Query: 71  ----SELIEQGRVVLWGQEGRPG---TPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPS 123
               SE I Q R      +G PG   TP      G   S   A +P      SS +   S
Sbjct: 213 EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272

Query: 124 PEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSK 183
            E   A  +                 + + G+  Q  A           PA E+P +G+ 
Sbjct: 273 EEETPAAKAL--------------LQAKASGKTSQVGAAS--------APAKESPRKGAA 310

Query: 184 SRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKKPGD 242
                +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K P  
Sbjct: 311 PAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKAPQV 359

Query: 243 TCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRP 302
                S   +ES  +   P   +PPR+  P   +  VG+ +  S    +           
Sbjct: 360 RAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE---------- 404

Query: 303 SCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVS 362
                       R  L    A + K L  +P++                   PAS     
Sbjct: 405 --------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS---TM 435

Query: 363 GVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
           G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+  L
Sbjct: 436 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 495



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 447 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 505

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 506 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 555 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 594

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 595 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 647

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 648 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 701

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 702 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 753

Query: 471 VHPPR 475
           V  P+
Sbjct: 754 VRNPQ 758


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 97/420 (23%), Positives = 144/420 (34%), Gaps = 88/420 (20%)

Query: 12  AGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE- 70
           +G  P    +  A+T        +G         +      G+ +S   D  S S E++ 
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV 212

Query: 71  ----SELIEQGRVVLWGQEGRPG---TPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPS 123
               SE I Q R      +G PG   TP      G   S   A +P      SS +   S
Sbjct: 213 EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272

Query: 124 PEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSK 183
            E   A  +                 + + G+  Q  A           PA E+P +G+ 
Sbjct: 273 EEETPAAKAL--------------LQAKASGKTSQVGAAS--------APAKESPRKGAA 310

Query: 184 SRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKKPGD 242
                +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K P  
Sbjct: 311 PAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKAPQV 359

Query: 243 TCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRP 302
                S   +ES  +   P   +PPR+  P   +  VG+ +  S    +           
Sbjct: 360 RAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE---------- 404

Query: 303 SCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVS 362
                       R  L    A + K L  +P++                   PAS     
Sbjct: 405 --------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS---TM 435

Query: 363 GVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
           G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+  L
Sbjct: 436 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 495



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 447 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 505

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 506 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 555 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 594

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 595 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 647

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 648 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 701

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 702 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 753

Query: 471 VHPPR 475
           V  P+
Sbjct: 754 VRNPQ 758


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 121/503 (24%), Positives = 163/503 (32%), Gaps = 102/503 (20%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--------KGESGFT-DPESF 65
           G +G   A     +PG P   G       GG    KG          KG++G   +P   
Sbjct: 395 GAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPV 454

Query: 66  SFESE-SELIEQGRVVLWGQEGRPGTP--VDDQAGGGDYSFYLADEPATIMPPSSVQGHP 122
             +       E+G+    G+ G  G P    ++ G G   F  AD  A    P+  +G P
Sbjct: 455 GVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSP 514

Query: 123 SPEGATAKGST-DIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERG 181
            P G   KGS  +     E G      L+ SPG     S GP   + P PGPA ++   G
Sbjct: 515 GPAGP--KGSPGEAGRPGEAGLPGAKGLTGSPG-----SPGPDGKTGP-PGPAGQDGRPG 566

Query: 182 SKSRLSFQVDPQQPSAEGPAGLN--TDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKK 239
                     P  P A G AG+        +A E             K G +  PG P  
Sbjct: 567 P---------PGPPGARGQAGVMGFPGPKGAAGEPG-----------KAGERGVPGPPGA 606

Query: 240 PGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVW---- 295
            G          ++     QG     PP    P  ER   G    P  + +         
Sbjct: 607 VGPA-------GKDGEAGAQG-----PPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGE 654

Query: 296 ----GKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAV 351
               G++GV P   GA    P P G  G +    ++ ++G P        PA  +  +  
Sbjct: 655 AGKPGEQGV-PGDLGA----PGPSGARGERGFPGERGVQGPPG-------PAGPRGANGA 702

Query: 352 PPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKK-----PAGRKTRESQAAAREDNDPNRD 406
           P +  +       G  G    P       PG++     P  +  R        D  P +D
Sbjct: 703 PGNDGAKGDAGAPGAPGSQGAP--GLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKD 760

Query: 407 EVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGD 466
            V     P   P        +GE              G S P+  T  R  P      GD
Sbjct: 761 GVRGLTGPIGPPGPAGAPGDKGE-------------SGPSGPAGPTGARGAP------GD 801

Query: 467 WQPPVHPPRPERQQQPPGAQGCP 489
              P  PP P     PPGA G P
Sbjct: 802 RGEP-GPPGPAGFAGPPGADGQP 823



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 94/373 (25%), Positives = 126/373 (33%), Gaps = 60/373 (16%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--KGESGFTDPESFSFESESE 72
           GP G + A     + G P   GH       G +   G    KGE G          +  +
Sbjct: 245 GPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENG----APGQ 300

Query: 73  LIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGAT-AKG 131
           +  +G   L G+ GRPG P    A G D +   A  P     P+   G P   GA  AKG
Sbjct: 301 MGPRG---LPGERGRPGAPGPAGARGNDGATGAAGPPG----PTGPAGPPGFPGAVGAKG 353

Query: 132 STDIWADLEVGPSW-RGALSPSPGEWQQASAGPLHLSVP--GPGPAWENPERGSKSRLSF 188
                   E GP   RG+  P     +    GP   + P   PG   +   +G+      
Sbjct: 354 --------EAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGI 405

Query: 189 QVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRS 248
              P  P A GP+G                         +G+  +PG+P   GDT  +  
Sbjct: 406 AGAPGFPGARGPSGPQGPGGPPG---------------PKGNSGEPGAPGSKGDTGAKGE 450

Query: 249 FHRRESYLQVQGPLLI-SPPRRLTPVVERPAVGELDVPSLKKMQSMVW--GKRGVRPSCS 305
                      GP+ +  PP       +R A GE     L          G RG   +  
Sbjct: 451 ----------PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADG 500

Query: 306 GAAVRGPL-PRGTLGRKVAQEKKSLEGAP-ELALRGAFPAWGQRLSAVPPDPASFPPVSG 363
            A  +GP   RG+ G    +      G P E  L GA    G    +  PD  + PP   
Sbjct: 501 VAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSP-GSPGPDGKTGPP--- 556

Query: 364 VGLLGKSVRPKEP 376
            G  G+  RP  P
Sbjct: 557 -GPAGQDGRPGPP 568



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 117/476 (24%), Positives = 150/476 (31%), Gaps = 88/476 (18%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFE-- 68
            R   GP G           G P   G+       G  +GK  GKG  G T P     E  
Sbjct: 865  RGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP-AGKEGGKGPRGETGPAGRPGEVG 923

Query: 69   ---SESELIEQGRVVLWGQEGRPGTP----VDDQAGGGDYSFYLADEPATIMP-PSSVQG 120
                     E+G     G  G PGTP    +  Q G         +     +P PS   G
Sbjct: 924  PPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPG 983

Query: 121  HPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPG----PGPAWE 176
               P GA+ +           GP     L+  PGE  +  A P     PG    PG   +
Sbjct: 984  KQGPSGASGERGPP-------GPMGPPGLAGPPGESGREGA-PGAEGSPGRDGSPGAKGD 1035

Query: 177  NPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGS 236
              E G          P  P   GPAG + D  ++       PV  V      G Q   G 
Sbjct: 1036 RGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGD 1095

Query: 237  PKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWG 296
              + G+  G R       +  +QGP    PP   +P  + P                   
Sbjct: 1096 KGETGEQ-GDRGIKGHRGFSGLQGP--PGPPG--SPGEQGP------------------- 1131

Query: 297  KRGVRPSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAP-ELALRGAFPAWGQRLSAVPPD 354
                    SGA+  GP  PRG  G   A  K  L G P  +   G     G      PP 
Sbjct: 1132 --------SGAS--GPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPG 1181

Query: 355  PASFPPVSGVGLLG--KSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQ 412
            P   P   G    G   S  P+ P+  +      GR  R   A    D D   D   ++ 
Sbjct: 1182 PPGPPGPPGPPSAGFDFSFLPQPPQEKA---HDGGRYYRADDANVVRDRDLEVDTTLKS- 1237

Query: 413  LPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQ 468
                              S    NIR+P+  G+ +  A T R L   CH+   DW+
Sbjct: 1238 -----------------LSQQIENIRSPE--GSRKNPARTCRDL-KMCHS---DWK 1270



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 94/384 (24%), Positives = 117/384 (30%), Gaps = 41/384 (10%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKG--KGKGESGFTDPESFSFE 68
            R   G  G + A     +PGAP   G        G+R   G    KG+ G   P+     
Sbjct: 697  RGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGS 756

Query: 69   SESELIE--QGRVVLWGQEGRPGT-----------PVDDQAGGGDYSFYLADEPATIMPP 115
               + +    G +   G  G PG            P   +   GD        PA    P
Sbjct: 757  PGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGP 816

Query: 116  SSVQGHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAW 175
                G P  +G       D  A  + GP      +  PG      A     +    GP  
Sbjct: 817  PGADGQPGAKGEPG----DAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPG 872

Query: 176  ENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPG 235
                 G+  R    V P  PS  G AG       +  E    P      + + G    PG
Sbjct: 873  ATGFPGAAGR----VGPPGPS--GNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPG 926

Query: 236  SPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAV-GELDVPSLKKMQSMV 294
             P   G+  G              GP  I+  R    VV  P   GE   P L    S  
Sbjct: 927  PPGPAGEK-GSPGADGPAGAPGTPGPQGIAGQR---GVVGLPGQRGERGFPGLPG-PSGE 981

Query: 295  WGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAP----ELALRGAFPAWGQRLSA 350
             GK+G  PS +      P P G  G      +   EGAP         G+  A G R   
Sbjct: 982  PGKQG--PSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGET 1039

Query: 351  VPPDPASFPPVSG----VGLLGKS 370
             P  P   P   G    VG  GKS
Sbjct: 1040 GPAGPPGAPGAPGAPGPVGPAGKS 1063


>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
          Length = 1257

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 66/275 (24%), Positives = 101/275 (36%), Gaps = 31/275 (11%)

Query: 13  GLGPEGGEQ-AGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
           G G  GG++  G H +  G   GDGHG     GG+ SG GKG G    +D +    +S  
Sbjct: 555 GHGSGGGQRPGGGHGSGGGQGPGDGHGSG---GGKNSGGGKGSGSGKGSDGDGERGKSLK 611

Query: 72  ELIEQGRVVLWGQEGRP-------------GTPVDDQAGGGDYSFYLADEPAT--IMPPS 116
           +    G++    Q+  P             GT    ++GG    ++  D  AT       
Sbjct: 612 KRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAK 671

Query: 117 SVQGHPSPEGATAKG-----STDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGP 171
            V+    PEGA A+G     + D   D    P   G  +P           P ++S    
Sbjct: 672 EVKDAEIPEGA-ARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPMAPQNVSASKK 730

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
             +  +P   S+  +        P A  P      D++  D+S D       +    G+ 
Sbjct: 731 RHS-RSPFEDSRGYMMMFPRVSPPPAPSPP--KAPDTNKEDDSKDNDSESDYMFMAPGAG 787

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISP 266
           A P +P+ P      +S+    SY  +  P   SP
Sbjct: 788 AIPKNPRNPQGGSSSKSW---SSYFSLPNPFRSSP 819


>gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]
          Length = 1860

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 82/278 (29%), Positives = 96/278 (34%), Gaps = 58/278 (20%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESE 70
            R  LGPEG E        PGAP  +G      F G R G    KGE G  DP        
Sbjct: 939  RGQLGPEGDE---GPMGPPGAPGLEGQPGRKGFPG-RPGLDGVKGEPG--DPGR-----P 987

Query: 71   SELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPS-PEGATA 129
              + EQG +   G  G PG  V ++   G         P  +  P    GHP  P G   
Sbjct: 988  GPVGEQGFMGFIGLVGEPGI-VGEKGDRGMMG------PPGVPGPKGSMGHPGMPGGMGT 1040

Query: 130  KGSTDIWADLEVGPSWR-GALSPSPGEWQQASAGPLHLSVPGP-GPAWENPERGSKSRLS 187
             G        E GP    G+  P      +   GP      GP GPA E   RG K    
Sbjct: 1041 PG--------EPGPQGPPGSRGPPGMRGAKGRRGPR-----GPDGPAGEQGSRGLKGPPG 1087

Query: 188  FQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRR 247
             Q  P +P  +G AG          E   L           GS+  PG P  P    G +
Sbjct: 1088 PQGRPGRPGQQGVAG----------ERGHL-----------GSRGFPGIP-GPSGPPGTK 1125

Query: 248  SFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVP 285
                       QGP  I PP  + P     AVGE  +P
Sbjct: 1126 GLPGEPGPQGPQGP--IGPPGEMGPKGPPGAVGEPGLP 1161



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 121/511 (23%), Positives = 165/511 (32%), Gaps = 113/511 (22%)

Query: 11   RAGLGPEG--GEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFE 68
            R   GP+G  GE+          P G      +     +SGK   KG +G    + +   
Sbjct: 1206 RGDPGPDGEHGEKGQEGLMGEDGPPGPPGVTGVRGPEGKSGKQGEKGRTGAKGAKGY--- 1262

Query: 69   SESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGAT 128
             + +L E G   + G  G PGTP    + G              + P+   G    +G  
Sbjct: 1263 -QGQLGEMG---VPGDPGPPGTPGPKGSRGS-------------LGPTGAPGRMGAQGEP 1305

Query: 129  AKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGP----GPAWENPERGSKS 184
                 D    + VGP   G   P   + +Q   G      PGP    GP  +  +RG   
Sbjct: 1306 GLAGYDGHKGI-VGPL--GPPGPKGEKGEQGEDGKAE-GPPGPPGDRGPVGDRGDRGEPG 1361

Query: 185  RLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTC 244
                  DP  P  EG  GL                       K G Q +PG P       
Sbjct: 1362 ------DPGYPGQEGVQGLR---------------------GKPGQQGQPGHP------- 1387

Query: 245  GRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSM--VWGKRGV-- 300
            G R +   +     +GP              +   G+   P  + +Q +  + G RGV  
Sbjct: 1388 GPRGWPGPKGSKGAEGP--------------KGKQGKAGAPGRRGVQGLQGLPGPRGVVG 1433

Query: 301  RPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
            R    G A    LP G  G+   Q ++  +G P     G     G+R +   P  A  P 
Sbjct: 1434 RQGLEGIAGPDGLP-GRDGQAGQQGEQGDDGDP-----GPMGPAGKRGN---PGVAGLPG 1484

Query: 361  VSG-VGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPE 419
              G  G  G+S  P +     PGK    R T           +P     P        P 
Sbjct: 1485 AQGPPGFKGESGLPGQ--LGPPGK----RGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPG 1538

Query: 420  LISLSVRRGEYS----SGDPNIRAPQVLGTSQPSAFTLRRLVPR-------CHASSGDW- 467
            +  L   +G        G    R P  L   +     L  L P           S GDW 
Sbjct: 1539 MAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGSRGDWG 1598

Query: 468  -QPPVHPPRPERQQQPPGAQGCPRCILLQRE 497
             Q P  PP P  +  PPG  G P  I LQ++
Sbjct: 1599 LQGPRGPPGPRGRPGPPGPPGGP--IQLQQD 1627



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 89/378 (23%), Positives = 131/378 (34%), Gaps = 83/378 (21%)

Query: 15   GPEG--GEQA--GAHTASPGAP--------RGD-GHGRDLNFGGQRSGKG-KGK----GE 56
            GP+G  GEQ   G     PG P        RGD G   D  + GQ   +G +GK    G+
Sbjct: 1324 GPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGKPGQQGQ 1383

Query: 57   SGFTDPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPS 116
             G   P  +     S+  E  +    G++G+ G P      G                  
Sbjct: 1384 PGHPGPRGWPGPKGSKGAEGPK----GKQGKAGAPGRRGVQG------------------ 1421

Query: 117  SVQGHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWE 176
             +QG P P G   +   +  A  +  P   G       +      GP+     GP     
Sbjct: 1422 -LQGLPGPRGVVGRQGLEGIAGPDGLPGRDGQAGQQGEQGDDGDPGPM-----GPAGKRG 1475

Query: 177  NPE----RGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQA 232
            NP      G++    F+ +   P   GP G         +  + LP          G+Q 
Sbjct: 1476 NPGVAGLPGAQGPPGFKGESGLPGQLGPPGKR-----GTEGRTGLP----------GNQG 1520

Query: 233  KPGSPKKPGDTCGRRSFHRRESYLQVQGP------LLISPPRRLTPVVERPA-VGELDVP 285
            +PGS  +PGD+ G   F         +GP        I  PR    ++ +   VG L + 
Sbjct: 1521 EPGSKGQPGDS-GEMGFPGMAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIVGPLGIL 1579

Query: 286  SLKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAP----ELALRGAF 341
                  S + G +G + S     ++G  PRG  G +         G P    +  L  AF
Sbjct: 1580 G----PSGLPGPKGDKGSRGDWGLQG--PRGPPGPRGRPGPPGPPGGPIQLQQDDLGAAF 1633

Query: 342  PAWGQRLSAVPPDPASFP 359
              W     A+ P+  S+P
Sbjct: 1634 QTWMDTSGALRPESYSYP 1651



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 124/528 (23%), Positives = 172/528 (32%), Gaps = 89/528 (16%)

Query: 15   GPEGGE-QAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKG--KGESGFTDPESFSFESES 71
            GP G + Q G    SPG    DG   D+   G     G    KG  G+  P     E   
Sbjct: 667  GPPGAKGQKGDPGLSPGKAH-DGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHPGEQGQ 725

Query: 72   ELIE--QGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA 129
               E   G     G++G PG PV D    G   +        +      +G P   G   
Sbjct: 726  PGPEGSPGAKGYPGRQGLPG-PVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRG 784

Query: 130  KGSTDIWADL--EVGPSWRGALSPSPGEWQQASAGPLHLSVPGP-------------GPA 174
            K     +  +  E GP     L  +PGE          L +PGP             GP 
Sbjct: 785  KMGMPGFPGVFGERGPP---GLDGNPGE----------LGLPGPPGVPGLIGDLGVLGPI 831

Query: 175  WENPERGSKSRLSFQVDPQ---QPSAEGPAGLNTDDSDSADESSDL------------PV 219
                 +G K  +    +P        +G  G++ D     D+ S              P+
Sbjct: 832  GYPGPKGMKGLMGSVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSQGLPGFPGARGKPGPL 891

Query: 220  IRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPR-RLTPVVERPA 278
             +V      G    PG    PGD  G    +  E      G   +  PR +L P  +   
Sbjct: 892  GKVGDKGSIGFPGPPGPEGFPGDI-GPPGDNGPEGMKGKPGARGLPGPRGQLGPEGDEGP 950

Query: 279  VGELDVPSLKKMQSMVWGKRGV--RPSCSGAAVRG----PLPRGTLGRKVAQEKKSLEGA 332
            +G    P L+       G++G   RP   G  V+G    P   G +G +       L G 
Sbjct: 951  MGPPGAPGLEGQP----GRKGFPGRPGLDG--VKGEPGDPGRPGPVGEQGFMGFIGLVGE 1004

Query: 333  PELALRGAFPAWGQRLSAVPPD-PASFPPVSGVGLLGKSVRPKEPKHSSP--GKKPAGRK 389
            P     G     G R    PP  P     +   G+ G    P EP    P   + P G +
Sbjct: 1005 P-----GIVGEKGDRGMMGPPGVPGPKGSMGHPGMPGGMGTPGEPGPQGPPGSRGPPGMR 1059

Query: 390  TRESQAAAREDNDPNRDE-------VPRAQLPTQKPELISLSVRRGEYSS-GDPNIRAPQ 441
              + +   R  + P  ++        P  Q    +P    ++  RG   S G P I  P 
Sbjct: 1060 GAKGRRGPRGPDGPAGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGP- 1118

Query: 442  VLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQQPPGAQGCP 489
                S P      + +P      G  Q P+ PP     + PPGA G P
Sbjct: 1119 ----SGPPG---TKGLPGEPGPQGP-QGPIGPPGEMGPKGPPGAVGEP 1158


>gi|27262667 colony stimulating factor 1 isoform a precursor [Homo
           sapiens]
          Length = 554

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 72/300 (24%), Positives = 107/300 (35%), Gaps = 67/300 (22%)

Query: 167 SVPGPGPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIIST 226
           ++P   PA  +P +           P  PS    AGL  +DS+  + SS LP  + + + 
Sbjct: 196 AIPSSDPASVSPHQ-----------PLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTV 244

Query: 227 KEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPS 286
             GS  +    + P  TC  +SF   E+ +     +  SP         RP+VG  + P 
Sbjct: 245 DPGSAKQ----RPPRSTC--QSFEPPETPVVKDSTIGGSPQ-------PRPSVGAFN-PG 290

Query: 287 LKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQ 346
           ++ +     G   V    SG A   P+P+GT      +   S  G   +    A P+   
Sbjct: 291 MEDILDSAMGTNWVPEEASGEASEIPVPQGT------ELSPSRPGGGSMQTEPARPS--N 342

Query: 347 RLSAVPPDPASFP---PVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDP 403
            LSA  P PAS     P    G     V P  P        P  +KT    A  R+  +P
Sbjct: 343 FLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTP--QKTDHPSALLRDPPEP 400

Query: 404 NRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHAS 463
                                        G P I + +  G S PS  + +  + R H+S
Sbjct: 401 -----------------------------GSPRISSLRPQGLSNPSTLSAQPQLSRSHSS 431


>gi|27262661 colony stimulating factor 1 isoform a precursor [Homo
           sapiens]
          Length = 554

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 72/300 (24%), Positives = 107/300 (35%), Gaps = 67/300 (22%)

Query: 167 SVPGPGPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIIST 226
           ++P   PA  +P +           P  PS    AGL  +DS+  + SS LP  + + + 
Sbjct: 196 AIPSSDPASVSPHQ-----------PLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTV 244

Query: 227 KEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPS 286
             GS  +    + P  TC  +SF   E+ +     +  SP         RP+VG  + P 
Sbjct: 245 DPGSAKQ----RPPRSTC--QSFEPPETPVVKDSTIGGSPQ-------PRPSVGAFN-PG 290

Query: 287 LKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQ 346
           ++ +     G   V    SG A   P+P+GT      +   S  G   +    A P+   
Sbjct: 291 MEDILDSAMGTNWVPEEASGEASEIPVPQGT------ELSPSRPGGGSMQTEPARPS--N 342

Query: 347 RLSAVPPDPASFP---PVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDP 403
            LSA  P PAS     P    G     V P  P        P  +KT    A  R+  +P
Sbjct: 343 FLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTP--QKTDHPSALLRDPPEP 400

Query: 404 NRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHAS 463
                                        G P I + +  G S PS  + +  + R H+S
Sbjct: 401 -----------------------------GSPRISSLRPQGLSNPSTLSAQPQLSRSHSS 431


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 88/363 (24%), Positives = 123/363 (33%), Gaps = 67/363 (18%)

Query: 68  ESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGA 127
           E ESE  E+G      +E   GT    +A         A  PA   P       P  +  
Sbjct: 267 EEESESSEEGSES--EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324

Query: 128 TAKGSTDIWADLEVGPSWRGALSPSPGEWQQASA-------GPLHLSVPGPGPAWENPER 180
                T      E   S     S S  E   A A       G          PA E+P +
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKK 239
           G+      +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K 
Sbjct: 385 GAAPAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKA 433

Query: 240 PGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRG 299
           P       S   +ES  +   P   +PPR+  P   +  VG+ +  S    +        
Sbjct: 434 PQVRAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE------- 481

Query: 300 VRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
                          R  L    A + K L  +P++                   PAS  
Sbjct: 482 -----------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS-- 510

Query: 360 PVSGVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQK 417
              G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+
Sbjct: 511 -TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 418 PEL 420
             L
Sbjct: 570 KSL 572



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 524 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 583 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 632 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 671

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 672 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 725 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 779 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830

Query: 471 VHPPR 475
           V  P+
Sbjct: 831 VRNPQ 835


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 88/363 (24%), Positives = 123/363 (33%), Gaps = 67/363 (18%)

Query: 68  ESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGA 127
           E ESE  E+G      +E   GT    +A         A  PA   P       P  +  
Sbjct: 267 EEESESSEEGSES--EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324

Query: 128 TAKGSTDIWADLEVGPSWRGALSPSPGEWQQASA-------GPLHLSVPGPGPAWENPER 180
                T      E   S     S S  E   A A       G          PA E+P +
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKK 239
           G+      +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K 
Sbjct: 385 GAAPAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKA 433

Query: 240 PGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRG 299
           P       S   +ES  +   P   +PPR+  P   +  VG+ +  S    +        
Sbjct: 434 PQVRAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE------- 481

Query: 300 VRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
                          R  L    A + K L  +P++                   PAS  
Sbjct: 482 -----------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS-- 510

Query: 360 PVSGVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQK 417
              G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+
Sbjct: 511 -TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 418 PEL 420
             L
Sbjct: 570 KSL 572



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 524 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 583 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 632 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 671

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 672 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 725 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 779 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830

Query: 471 VHPPR 475
           V  P+
Sbjct: 831 VRNPQ 835


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 88/363 (24%), Positives = 123/363 (33%), Gaps = 67/363 (18%)

Query: 68  ESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGA 127
           E ESE  E+G      +E   GT    +A         A  PA   P       P  +  
Sbjct: 267 EEESESSEEGSES--EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324

Query: 128 TAKGSTDIWADLEVGPSWRGALSPSPGEWQQASA-------GPLHLSVPGPGPAWENPER 180
                T      E   S     S S  E   A A       G          PA E+P +
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKK 239
           G+      +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K 
Sbjct: 385 GAAPAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKA 433

Query: 240 PGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRG 299
           P       S   +ES  +   P   +PPR+  P   +  VG+ +  S    +        
Sbjct: 434 PQVRAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE------- 481

Query: 300 VRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
                          R  L    A + K L  +P++                   PAS  
Sbjct: 482 -----------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS-- 510

Query: 360 PVSGVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQK 417
              G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+
Sbjct: 511 -TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 418 PEL 420
             L
Sbjct: 570 KSL 572



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 524 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 583 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 632 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 671

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 672 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 725 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 779 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830

Query: 471 VHPPR 475
           V  P+
Sbjct: 831 VRNPQ 835


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 88/363 (24%), Positives = 123/363 (33%), Gaps = 67/363 (18%)

Query: 68  ESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGA 127
           E ESE  E+G      +E   GT    +A         A  PA   P       P  +  
Sbjct: 267 EEESESSEEGSES--EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324

Query: 128 TAKGSTDIWADLEVGPSWRGALSPSPGEWQQASA-------GPLHLSVPGPGPAWENPER 180
                T      E   S     S S  E   A A       G          PA E+P +
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384

Query: 181 GSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEG-SQAKPGSPKK 239
           G+      +  P    A+  AG   +DS S+ E SD        S +E  +QAKP S K 
Sbjct: 385 GAAPAPPGKTGPAVAKAQ--AGKREEDSQSSSEESD--------SEEEAPAQAKP-SGKA 433

Query: 240 PGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRG 299
           P       S   +ES  +   P   +PPR+  P   +  VG+ +  S    +        
Sbjct: 434 PQVRAA--SAPAKESPRKGAAP---APPRKTGPAAAQVQVGKQEEDSRSSSEE------- 481

Query: 300 VRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFP 359
                          R  L    A + K L  +P++                   PAS  
Sbjct: 482 -----------SDSDREALAAMNAAQVKPLGKSPQVK------------------PAS-- 510

Query: 360 PVSGVGLLGKSVRPKEPKHSSPGKKPA--GRKTRESQAAAREDNDPNRDEVPRAQLPTQK 417
              G+G LGK   P  P    P    A  G+   +S++++ E +D +  EVP A  P Q+
Sbjct: 511 -TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 418 PEL 420
             L
Sbjct: 570 KSL 572



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/365 (20%), Positives = 125/365 (34%), Gaps = 55/365 (15%)

Query: 113 MPPSSVQGHPSPEGATAKGSTDIWADLEVGP-SWRGALSPSPGEWQQASAGPLHLSVPGP 171
           +PP  V G  +P     K   D  +  E    S  G +  +    Q+ S G +  + P  
Sbjct: 524 VPPGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582

Query: 172 GPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQ 231
            PA   P++     ++ QV  ++P          D+S+S++ESSD        +    +Q
Sbjct: 583 SPAKGPPQKAGP--VAVQVKAEKPM---------DNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 232 AKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQ 291
           AKP         C +++               ++P R  T    +               
Sbjct: 632 AKPALKIPQTKACPKKT--------NTTASAKVAPVRVGTQAPRKAGT------------ 671

Query: 292 SMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALR-GAFPAWGQRLSA 350
                     P+ S  AV G   R       ++E  S E    LA+  G   + G+ L  
Sbjct: 672 -------ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724

Query: 351 VPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPR 410
                A+  PV   G LG+   P  P  + P       + +E   ++ E++D        
Sbjct: 725 ----KAASVPVK--GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778

Query: 411 AQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPP 470
           AQ+ T        SV++ +  +     RAP   GT       +         S    +PP
Sbjct: 779 AQVKT--------SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830

Query: 471 VHPPR 475
           V  P+
Sbjct: 831 VRNPQ 835


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 90/416 (21%), Positives = 132/416 (31%), Gaps = 68/416 (16%)

Query: 109  PATIMPPSSVQGHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSV 168
            PAT  P    +G P+P  AT              PS +G L+  P    + +  P  ++ 
Sbjct: 1255 PATPPP----KGAPTPPAATP-------------PSLKGGLATPP---HKGAPNPAVVTP 1294

Query: 169  PGP--GPAWENPERGSKSRLSFQVDPQ-QPSAEGPAGLNTDDSDSADESSDLPVIRVIIS 225
            P P  GPA   P+       +    P+  P    P G  T  + +       P +     
Sbjct: 1295 PSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTP 1354

Query: 226  TKEGSQAKPGS---PKKPGDTCGRRSFHRRESYLQVQGPLLISP-------------PRR 269
            + +G    P S   P  P  T   +           +GP + SP             P++
Sbjct: 1355 SSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKK 1414

Query: 270  L--TPVVER----PAVGELDVP-----SLKKMQSMVWGKRG-VRPSCSG----AAVRGPL 313
               TPV       P+ G+L  P     SLKK  +    K G   PS  G     AV  P 
Sbjct: 1415 APATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPS 1474

Query: 314  PRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRP 373
            P+       A ++ +   +P+ A     P     L AV P      P +          P
Sbjct: 1475 PK----EPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATP----SSRRDP 1526

Query: 374  KEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSG 433
              P  +   KK       +          P+  + P    P + P   S      + +S 
Sbjct: 1527 IAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPS-----SKEASS 1581

Query: 434  DPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQQPPGAQGCP 489
             P +      G   P    +   V           P V PP PE+    P  +G P
Sbjct: 1582 PPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTP 1637



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 50/208 (24%), Positives = 72/208 (34%), Gaps = 27/208 (12%)

Query: 302  PSCSGAAVRGP-LPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPP 360
            P+  G+A  GP  P G L   V+  + S      L+ +G+  +     S  PP P   P 
Sbjct: 809  PTKKGSA--GPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866

Query: 361  VSGVGLL---GKSVRPKE---------------PKHSSPGKKPAGRKTRESQAAAREDND 402
             S V  L   G ++ PKE               P   +P + PA   T  S   AR    
Sbjct: 867  PSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPA 926

Query: 403  PNRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHA 462
            P    +P +  P   P   +          G P   +P+   T   +     +  P   +
Sbjct: 927  PK--GIPASPSPKGAP---TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPS 981

Query: 463  SSGDWQPP-VHPPRPERQQQPPGAQGCP 489
              G   PP   PP P+     P  +G P
Sbjct: 982  PKGAPTPPAATPPSPKGGPATPSPKGAP 1009


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 103/424 (24%), Positives = 131/424 (30%), Gaps = 78/424 (18%)

Query: 14   LGPEG--GEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESES 71
            +GP G  GE+  +   +PG P   G   +    G     G  KG+ GF  P         
Sbjct: 1438 VGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGP-KGDRGFPGP----LGEAG 1492

Query: 72   ELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKG 131
            E  E+G     G  G PG      A G          P     P+  QG     G    G
Sbjct: 1493 EKGERGPPGPAGSRGLPGVAGRPGAKG----------PEGPPGPTGRQGEKGEPGRP--G 1540

Query: 132  STDIWADLEVGPSWR----GALSPSPGEWQQASAGPLHLSVPG-PGPAWENPERG----- 181
               +      GP       G   P      Q   GP  L +PG PGP  +  +RG     
Sbjct: 1541 DPAVVGPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLT 1600

Query: 182  -------SKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKP 234
                          + DP +P   GP G    D +  +               +G +  P
Sbjct: 1601 GRAGPPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGE---------------KGDEGPP 1645

Query: 235  GSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGE--LDVPSLKKMQS 292
            G P  PG   G R               L   P    PV E+   G+   D  +     S
Sbjct: 1646 GDPGLPG-KAGERG--------------LRGAPGVRGPVGEKGDQGDPGEDGRNGSPGSS 1690

Query: 293  MVWGKRGVRPSCSGAAVR------GPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQ 346
               G RG  P   G   R      G   +G  G +  +  +  +G P   L GA    G 
Sbjct: 1691 GPKGDRG-EPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDP--GLPGAPGERGI 1747

Query: 347  RLSAVPPDPASFPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNR 405
                 PP P   P V G  G  G    P     S    KP          AA +  DP R
Sbjct: 1748 EGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAAGPSGPNGAAGKAGDPGR 1807

Query: 406  DEVP 409
            D +P
Sbjct: 1808 DGLP 1811



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 108/446 (24%), Positives = 140/446 (31%), Gaps = 84/446 (18%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGH-GRDLNFGGQRSGKGKGKGESGFTDPESFSFESESEL 73
            GP G   A      PGA    G  GR  N G    G    KG  G   P           
Sbjct: 1287 GPPGSATAKGERGFPGADGRPGSPGRAGNPG--TPGAPGLKGSPGLPGPRG--------- 1335

Query: 74   IEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPS--SVQGHPSPEGATAKG 131
             + G     G +G PG P     G G        +P    PP      G P P G     
Sbjct: 1336 -DPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGLP 1394

Query: 132  STDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVD 191
             T +  D                +  +   GP     PGPG     P       L     
Sbjct: 1395 GTAMKGD----------------KGDRGERGP-----PGPGEGGIAPGEPGLPGLPGSPG 1433

Query: 192  PQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHR 251
            PQ P   GP G   +  DS D +  LP  +     ++G +  PG+    GD  G      
Sbjct: 1434 PQGPV--GPPGKKGEKGDSEDGAPGLPG-QPGSPGEQGPRGPPGAIGPKGDR-GFPGPLG 1489

Query: 252  RESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRG--VRPSCSGAAV 309
                   +GP   +  R L  V  RP     + P     +    G+ G    P+  G AV
Sbjct: 1490 EAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGEPGRPGDPAVVGPAV 1549

Query: 310  RGPLPR----GTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSG-V 364
             GP       G  G + A   +   G P L L G             P P   P   G +
Sbjct: 1550 AGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPG------------DPGPKGDPGDRGPI 1597

Query: 365  GLLGKSVRPKEPKHSSPGKK----------PAGRKTRESQAAAREDNDPNRDEVPRAQLP 414
            GL G++  P +     PG+K          P G + R+ +   + D  P  D        
Sbjct: 1598 GLTGRAGPPGD--SGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEGPPGD-------- 1647

Query: 415  TQKPELISLSVRRGEYSSGDPNIRAP 440
               P L   +  RG    G P +R P
Sbjct: 1648 ---PGLPGKAGERG--LRGAPGVRGP 1668



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 62/218 (28%), Positives = 74/218 (33%), Gaps = 29/218 (13%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGD------GHGRDLNFGGQRSGKGKG--KGESGFTDP 62
            R  LGP+G   A      PG+P  D      G   D+ F G R  KG+   KG  G    
Sbjct: 2580 RGLLGPQGQPGAAGIPGDPGSPGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGE 2639

Query: 63   ESFSFESESELIEQGRVVLWGQEGRPGTP-VDDQAGG----------GDYSFYLADEPAT 111
            +      + E    GR  L G +G  G P V  Q+G           GD  F     P  
Sbjct: 2640 KG----DKGEAGPPGRPGLAGHKGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKG 2695

Query: 112  IMPPSSVQGHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPG- 170
                   +G P   G       D  A     P   G   P   + Q+   GP    V G 
Sbjct: 2696 DQGEKGERGTPGIGGFPGPSGNDGSAGPPGPPGSVGPRGPEGLQGQKGERGPPGERVVGA 2755

Query: 171  PGPAWENPERGSKSRLSFQVDPQQPSAE-GPAGLNTDD 207
            PG      ERG + R      P  P  E G A L  DD
Sbjct: 2756 PGVPGAPGERGEQGR----PGPAGPRGEKGEAALTEDD 2789



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 76/335 (22%), Positives = 102/335 (30%), Gaps = 73/335 (21%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
            GP+G           G P     GR L       G     G SG   P+           
Sbjct: 2198 GPQGPSGLKGEPGETGPP-----GRGLTGPTGAVGLPGPPGPSGLVGPQG---------- 2242

Query: 75   EQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPAT--IMPPSSVQGHPSPEGATAKGS 132
              G     G+ G+PG P  D A G D        P +  +  P   +G P P GA  +  
Sbjct: 2243 SPGLPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAV 2302

Query: 133  TDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDP 192
                  L      +GA     G+            +PGP        RG K       +P
Sbjct: 2303 ----VGLPGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGP--------RGEKGEAGRAGEP 2350

Query: 193  QQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRR 252
              P  +G  G         D    +P          GS   PG P   GD          
Sbjct: 2351 GDPGEDGQKGAPGPKGFKGDPGVGVP----------GSPGPPGPPGVKGD---------- 2390

Query: 253  ESYLQVQG----PLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAA 308
               L + G    P ++  P +  P       GE+  P          G+RG+        
Sbjct: 2391 ---LGLPGLPGAPGVVGFPGQTGP------RGEMGQPGPS-------GERGLAGPPGREG 2434

Query: 309  VRGPL----PRGTLGRKVAQEKKSLEGAPELALRG 339
            + GPL    P G++G   A   K  +G P + L G
Sbjct: 2435 IPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPG 2469



 Score = 35.8 bits (81), Expect = 0.097
 Identities = 62/235 (26%), Positives = 74/235 (31%), Gaps = 66/235 (28%)

Query: 15   GPEGGEQAGAHTASPG--APRGD----GHGRDLNFGGQRSGKGKG--KGESGFTDPESFS 66
            GP G + A     S G   P+GD    G   D    G R   G     GE G   PE   
Sbjct: 2108 GPPGLKGAKGEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGNPGLPGERGMAGPE--- 2164

Query: 67   FESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEG 126
                      G+  L G  G PG PV      G         PA    PS ++G P    
Sbjct: 2165 ----------GKPGLQGPRGPPG-PVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEPG--- 2210

Query: 127  ATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRL 186
                         E GP  RG   P+         G + L  P PGP+     +GS    
Sbjct: 2211 -------------ETGPPGRGLTGPT---------GAVGLPGP-PGPSGLVGPQGSPGLP 2247

Query: 187  SFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPG 241
                +  +P A G  G +  D D                   GS   PGSP  PG
Sbjct: 2248 GQVGETGKPGAPGRDGASGKDGD------------------RGSPGVPGSPGLPG 2284



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 116/491 (23%), Positives = 160/491 (32%), Gaps = 70/491 (14%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQ--RSGKGKGKGESGFTDPESFSFESESE 72
            GP G +        PGA    G        G   R G    +GE G   P S       +
Sbjct: 1773 GPPGLDGRSGLDGKPGAAGPSGPNGAAGKAGDPGRDGLPGLRGEQGLPGP-SGPPGLPGK 1831

Query: 73   LIEQGRVVLWGQEGRPGTPVDDQAGG--GDYSFYLADEPATIMPPSSVQGHPSPEGATAK 130
              E G+  L G+ G PG P +D   G  GD               S  +G   P+G   +
Sbjct: 1832 PGEDGKPGLNGKNGEPGDPGEDGRKGEKGDSG------------ASGREGRDGPKG--ER 1877

Query: 131  GSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQV 190
            G+  I    +  P   G + P PG+      G       G GP  +  E GSK     Q 
Sbjct: 1878 GAPGILGP-QGPPGLPGPVGP-PGQGFPGVPG-------GTGPKGDRGETGSKGE---QG 1925

Query: 191  DPQQPSAEGPAGLNTDDSDSADESSDL--PVIRVIISTKEGSQAK----PGSPKKPGDTC 244
             P +    G  G +  + D   E++ +    +R I+ T + S       P   + P    
Sbjct: 1926 LPGERGLRGEPG-SVPNVDRLLETAGIKASALREIVETWDESSGSFLPVPERRRGPKGDS 1984

Query: 245  GRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSC 304
            G +    +E  +   G              ER   G+   P  +    +  G+RG  P  
Sbjct: 1985 GEQGPPGKEGPIGFPG--------------ERGLKGDRGDPGPQGPPGLALGERG-PPGP 2029

Query: 305  SGAAVRGPLP--RGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVS 362
            SG A     P   G  GR     +    G      RG     G+R       P   P   
Sbjct: 2030 SGLAGEPGKPGIPGLPGRAGGVGEAGRPGE-----RGERGEKGERGEQGRDGPPGLPGTP 2084

Query: 363  G-VGLLGKSVRPKEPKHSSPGKK-PAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPEL 420
            G  G  G  V   EP     G++ P G K  + +  +  D  P  D      +P  K + 
Sbjct: 2085 GPPGPPGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQGPKGDR----GVPGIKGDR 2140

Query: 421  ISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHP--PRPER 478
                 R  + + G P  R   + G          R  P      GD  PP  P    P  
Sbjct: 2141 GEPGPRGQDGNPGLPGERG--MAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAG 2198

Query: 479  QQQPPGAQGCP 489
             Q P G +G P
Sbjct: 2199 PQGPSGLKGEP 2209



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 120/522 (22%), Positives = 155/522 (29%), Gaps = 89/522 (17%)

Query: 15   GPEGGEQAGAHTASPG-------APRGD-GHGRDLNFGGQR-----SGKGKGKGESGFTD 61
            GP G          PG        P+GD G    +   G+      SG    KG+ G   
Sbjct: 1563 GPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPG 1622

Query: 62   PESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSV--Q 119
            P          +  +GR    G++G  G P D    G      L   P    P      Q
Sbjct: 1623 PPG-------PVGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQ 1675

Query: 120  GHPSPEGATAKGSTDIWADLEVGPSW-RGALSPSPGEWQQASAGPLHLSVPGPGPAWENP 178
            G P  +G      +        GP   RG   P     +    GP       PG   +  
Sbjct: 1676 GDPGEDGRNGSPGSS-------GPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEG 1728

Query: 179  ERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTK----------- 227
             RG K       DP  P A G  G+         +    P +R     K           
Sbjct: 1729 PRGPKG------DPGLPGAPGERGIEGFRGPPGPQGD--PGVRGPAGEKGDRGPPGLDGR 1780

Query: 228  EGSQAKPGS--PKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVP 285
             G   KPG+  P  P    G+     R+    ++G   +  P     +  +P  GE   P
Sbjct: 1781 SGLDGKPGAAGPSGPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKP--GEDGKP 1838

Query: 286  SLKKMQSMVWGKRGVRPSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPEL-------AL 337
             L        GK G          +G     G  GR+     K   GAP +        L
Sbjct: 1839 GLN-------GKNGEPGDPGEDGRKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPGL 1891

Query: 338  RGAFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKE-PKHSSPGKKPAGRKTRES--- 393
             G     GQ    VP            G  G+   P E      PG  P   +  E+   
Sbjct: 1892 PGPVGPPGQGFPGVPGGTGPKGDRGETGSKGEQGLPGERGLRGEPGSVPNVDRLLETAGI 1951

Query: 394  QAAAREDNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTL 453
            +A+A  +     DE   + LP   PE      RRG    GD   + P   G   P  F  
Sbjct: 1952 KASALREIVETWDESSGSFLPV--PER-----RRG--PKGDSGEQGPP--GKEGPIGFPG 2000

Query: 454  RRLVPRCHASSGDWQPP------VHPPRPERQQQPPGAQGCP 489
             R +       G   PP        PP P      PG  G P
Sbjct: 2001 ERGLKGDRGDPGPQGPPGLALGERGPPGPSGLAGEPGKPGIP 2042


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 118/494 (23%), Positives = 152/494 (30%), Gaps = 110/494 (22%)

Query: 13   GLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESE 72
            G GP+G       T   G P   G G D             KG++G   P+         
Sbjct: 601  GPGPQGPPGKNGETGPQGPPGPTGPGGD-------------KGDTGPPGPQ--------- 638

Query: 73   LIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGS 132
                      G +G PGT      GG         EP     P    G P   G    G 
Sbjct: 639  ----------GLQGLPGT------GGPPGENGKPGEPG----PKGDAGAPGAPG----GK 674

Query: 133  TDIWADLEVG-------PSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENP------- 178
             D  A  E G       P  RG   P   E  + +AGP     PGP  A   P       
Sbjct: 675  GDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGP-----PGPPGAAGTPGLQGMPG 729

Query: 179  ERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPK 238
            ERG       + D  +P   G  G+   D          P+     + + G + + G+P 
Sbjct: 730  ERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTG---PIGPPGPAGQPGDKGEGGAPG 786

Query: 239  KPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKR 298
             PG   G R            GP     P       E    GE   P  K       G  
Sbjct: 787  LPG-IAGPRGSPGERGETGPPGP--AGFPGAPGQNGEPGGKGERGAPGEKG----EGGPP 839

Query: 299  GVRPSCSGAAVRGPL-PRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPAS 357
            GV     G+   GP  P+G  G + +       G P    RG     G   +  PP P+ 
Sbjct: 840  GVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFP--GARGLPGPPGSNGNPGPPGPSG 897

Query: 358  FPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQ 416
             P   G  G  G +  P  P  S P K  AG+              P     P AQ P  
Sbjct: 898  SPGKDGPPGPAGNTGAPGSPGVSGP-KGDAGQ--------------PGEKGSPGAQGPPG 942

Query: 417  KPELISLSVRRGEYS-SGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPR 475
             P  + ++   G    +G P +  P+  G+  P         P  +  SG          
Sbjct: 943  APGPLGIAGITGARGLAGPPGMPGPR--GSPGPQGVKGESGKPGANGLSG---------- 990

Query: 476  PERQQQPPGAQGCP 489
               ++ PPG QG P
Sbjct: 991  ---ERGPPGPQGLP 1001



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 56/234 (23%), Positives = 68/234 (29%), Gaps = 31/234 (13%)

Query: 15   GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
            GP G +       + G P  DG+       G R G   GKG+ G                
Sbjct: 993  GPPGPQGLPGLAGTAGEPGRDGNPGSDGLPG-RDGSPGGKGDRG---------------- 1035

Query: 75   EQGRVVLWGQEGRPGTP--VDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATA-KG 131
            E G     G  G PG P  V      GD        PA    P+  +G P P+G    KG
Sbjct: 1036 ENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKG 1095

Query: 132  STDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVD 191
             T        G         +PG            ++  PGPA      G          
Sbjct: 1096 ETGERG--AAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGT 1153

Query: 192  PQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCG 245
               P   GP G   +  +   E S             G    PG P  PG  CG
Sbjct: 1154 SGHPGPIGPPGPRGNRGERGSEGSP---------GHPGQPGPPGPPGAPGPCCG 1198



 Score = 35.8 bits (81), Expect = 0.097
 Identities = 108/443 (24%), Positives = 134/443 (30%), Gaps = 83/443 (18%)

Query: 11   RAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKG----KG-KGESGFTDPESF 65
            R G GP G E        PG P   G        G+R G G    KG KGE G    +  
Sbjct: 695  RGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGV 754

Query: 66   SFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLA------DEPATIMPPSSVQ 119
              +       +G     G  G  G P D   GG      +A       E     PP    
Sbjct: 755  PGKDG----PRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPA- 809

Query: 120  GHPSPEGATAK--GSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWEN 177
            G P   G   +  G  +  A  E G      ++  PG      AGP       PGP    
Sbjct: 810  GFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPG--GSGPAGP-------PGPQGVK 860

Query: 178  PERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSP 237
             ERGS         P      GP G N +                      GS  K G P
Sbjct: 861  GERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPG---------------PSGSPGKDGPP 905

Query: 238  KKPGDTCGRRSFHRRESYLQVQGPL--LISPPRRLTPVVERP--AVGELDVPSLKKMQSM 293
               G+T    S         V GP      P  + +P  + P  A G L +  +   + +
Sbjct: 906  GPAGNTGAPGS-------PGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGL 958

Query: 294  VWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPP 353
              G  G+           P PRG+ G    Q  K   G P     GA    G+R    PP
Sbjct: 959  A-GPPGM-----------PGPRGSPG---PQGVKGESGKP-----GANGLSGER---GPP 995

Query: 354  DPASFPPVSG-VGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQ 412
             P   P ++G  G  G+   P           P G+  R    +      P     P   
Sbjct: 996  GPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPV 1055

Query: 413  LPTQKPELISLSVRRGEYSSGDP 435
             P  K      S  RGE     P
Sbjct: 1056 GPAGK------SGDRGESGPAGP 1072



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 94/415 (22%), Positives = 129/415 (31%), Gaps = 84/415 (20%)

Query: 15  GPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELI 74
           GP G      H  SPG+P   G   +    G  SG     G  G + P            
Sbjct: 180 GPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGP-SGPPGPPGAIGPSGPAGKD-------- 230

Query: 75  EQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGSTD 134
                   G+ GRPG P +    G          P  I  P+ + G P  +G       +
Sbjct: 231 --------GESGRPGRPGERGLPG----------PPGIKGPAGIPGFPGMKGHRGFDGRN 272

Query: 135 IWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQ 194
                   P  +G  +  PGE    + GP+       GP     ERG            +
Sbjct: 273 GEKGETGAPGLKGE-NGLPGE--NGAPGPM-------GPRGAPGERG------------R 310

Query: 195 PSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGD-----------T 243
           P   G AG   +D     +    P          G+   PGSP   G+            
Sbjct: 311 PGLPGAAGARGNDGARGSDGQPGP------PGPPGTAGFPGSPGAKGEVGPAGSPGSNGA 364

Query: 244 CGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPS 303
            G+R     + +   QGP    PP        +  +G   +P    +     G RG  P 
Sbjct: 365 PGQRGEPGPQGHAGAQGP--PGPPGINGSPGGKGEMGPAGIPGAPGLM----GARG-PPG 417

Query: 304 CSGA----AVRG----PLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDP 355
            +GA     +RG    P   G  G    + ++   G P   + GA    G+  S   P  
Sbjct: 418 PAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIP--GVPGAKGEDGKDGSPGEPGA 475

Query: 356 ASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAR-EDNDPNRDEVP 409
              P  +G         P  P      K PAG +     A  R    +P RD VP
Sbjct: 476 NGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVP 530



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 78/314 (24%), Positives = 110/314 (35%), Gaps = 63/314 (20%)

Query: 83  GQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPS-PEGATAK-GSTDIWADLE 140
           G +G PG P      G          P +  PP   +  P+ P+  + +  S D+ + + 
Sbjct: 106 GPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVA 165

Query: 141 VGPSWRGALSPSPGEWQQASAGPLHLSVPGP-GPAWENPERGSKSRLSFQVDPQQPSAEG 199
           VG      L+  PG      AGP     PGP GP   +   GS     +Q  P +P   G
Sbjct: 166 VG-----GLAGYPGP-----AGP-----PGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAG 210

Query: 200 PAG-------LNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRR 252
           P+G       +        D  S  P        + G +  PG P   G   G   F   
Sbjct: 211 PSGPPGPPGAIGPSGPAGKDGESGRP-------GRPGERGLPGPPGIKG-PAGIPGFPGM 262

Query: 253 ESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGP 312
           + +    G                   GE   P LK       G+ G+ P  +GA   GP
Sbjct: 263 KGHRGFDG--------------RNGEKGETGAPGLK-------GENGL-PGENGAP--GP 298

Query: 313 L-PRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGV-GLLGKS 370
           + PRG  G +         GA      GA  + GQ     PP  A FP   G  G +G +
Sbjct: 299 MGPRGAPGERGRPGLPGAAGA--RGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPA 356

Query: 371 VRPKEPKHSSPGKK 384
             P    + +PG++
Sbjct: 357 GSP--GSNGAPGQR 368


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 69/339 (20%), Positives = 107/339 (31%), Gaps = 63/339 (18%)

Query: 150 SPSPGEWQQASAGPLHLSVPGPGPA------WENPERGSKSRLSFQVDPQQPSAEGPAGL 203
           +PSP   +++ A    + +P P P+       E P +   S          P+A      
Sbjct: 171 TPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA 230

Query: 204 NTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLL 263
                  A  S       +    + G  A+ G+P+ P           +   LQ   P  
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSAR-GTPRAPAHPS-----QPKPKGLQALRPPQ 284

Query: 264 ISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVA 323
           ++PPR+       PA+G L                      S + +  P P GT  R V 
Sbjct: 285 VTPPRKDAA----PALGPL----------------------SSSPLATPSPSGTKARPVP 318

Query: 324 QEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGK 383
               +    P  A     P     L   PP P++ P +  +           P  + P +
Sbjct: 319 PPDNAATPLP--ATLPPSPPLATPLPLAPPSPSAPPSLQTL---------PSPPATPPSQ 367

Query: 384 KPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQ--------KPELISLSVRRGEYSSGDP 435
            P    T   QA       P+   +P  Q+P           P  ++LS  +   S G P
Sbjct: 368 APPSMTTPPMQAP------PSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSP 421

Query: 436 NIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPP 474
            ++A     T  P         P   AS+    PP+  P
Sbjct: 422 TLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAP 460


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 74/346 (21%), Positives = 117/346 (33%), Gaps = 72/346 (20%)

Query: 109 PATIMPPSSVQGHPSPEGA--TAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHL 166
           P++  PPS+ Q  P P  +  ++   ++  +D +         S S  E  +    PL  
Sbjct: 445 PSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENE----PLET 500

Query: 167 SVPGPGPAWEN----------------PERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDS 210
             P P P   N                P  G +S      +P +   E     ++  S  
Sbjct: 501 PAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRS-----TEPPRRHPESKGSSDSATSQE 555

Query: 211 ADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRL 270
             ES D P        K  S+A    P+ P    G+RS  +         P    PP+R 
Sbjct: 556 HSESKDPP-------PKSSSKAPRAPPEAPHP--GKRSCQK--------SPAQQEPPQRQ 598

Query: 271 TPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKK-SL 329
           T   ++P           K       + G R S  G    G LP G+  +    + K   
Sbjct: 599 TVGTKQP-----------KKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKT 647

Query: 330 EGAPELAL----RGAFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKH------- 378
           +G P  A     + A P   ++       PA    +SG      +V  + P+H       
Sbjct: 648 KGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLT 707

Query: 379 --SSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPELIS 422
               P    +G +T   + A     D  +D +P   LP +  +L+S
Sbjct: 708 ESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLP---LPLRDTKLLS 750


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,489,849
Number of Sequences: 37866
Number of extensions: 1745970
Number of successful extensions: 7972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 404
Number of HSP's that attempted gapping in prelim test: 6937
Number of HSP's gapped (non-prelim): 1372
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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