BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239749791 PREDICTED: similar to hCG1644292 [Homo sapiens] (671 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239749791 PREDICTED: similar to hCG1644292 [Homo sapiens] 1373 0.0 gi|239755296 PREDICTED: similar to hCG1644292 [Homo sapiens] 1369 0.0 gi|126091152 cubilin [Homo sapiens] 457 e-128 gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 241 2e-63 gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 198 2e-50 gi|239757619 PREDICTED: similar to hCG1644292 [Homo sapiens] 186 5e-47 gi|239752110 PREDICTED: hypothetical protein XP_002348113 [Homo ... 186 5e-47 gi|239743843 PREDICTED: hypothetical protein XP_002342968 [Homo ... 171 2e-42 gi|239743812 PREDICTED: similar to hCG1644292 [Homo sapiens] 171 2e-42 gi|239758143 PREDICTED: similar to hCG1644292 [Homo sapiens] 165 1e-40 gi|22547221 tolloid-like 1 [Homo sapiens] 102 1e-21 gi|6912724 tolloid-like 2 [Homo sapiens] 97 6e-20 gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 94 5e-19 gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 86 9e-17 gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 86 9e-17 gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 82 2e-15 gi|72384339 CUB domain containing protein 2 [Homo sapiens] 79 2e-14 gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 73 1e-12 gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens] 72 2e-12 gi|239756223 PREDICTED: ankyrin repeat domain-containing protein... 68 3e-11 gi|169209369 PREDICTED: similar to Putative ankyrin repeat domai... 68 3e-11 gi|239745040 PREDICTED: ankyrin repeat domain-containing protein... 68 3e-11 gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre... 67 5e-11 gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre... 67 5e-11 gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 62 2e-09 gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 62 2e-09 gi|148539844 deleted in malignant brain tumors 1 isoform c precu... 62 2e-09 gi|148539842 deleted in malignant brain tumors 1 isoform b precu... 62 2e-09 gi|148539840 deleted in malignant brain tumors 1 isoform a precu... 62 2e-09 gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 61 4e-09 >gi|239749791 PREDICTED: similar to hCG1644292 [Homo sapiens] Length = 671 Score = 1373 bits (3554), Expect = 0.0 Identities = 671/671 (100%), Positives = 671/671 (100%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC Sbjct: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 Query: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT Sbjct: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 Query: 121 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR Sbjct: 121 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 Query: 181 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 240 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP Sbjct: 181 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 240 Query: 241 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF 300 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF Sbjct: 241 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF 300 Query: 301 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR 360 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR Sbjct: 301 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR 360 Query: 361 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR 420 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR Sbjct: 361 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR 420 Query: 421 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA 480 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA Sbjct: 421 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA 480 Query: 481 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD 540 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD Sbjct: 481 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD 540 Query: 541 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT 600 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT Sbjct: 541 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT 600 Query: 601 AKETSEKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS 660 AKETSEKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS Sbjct: 601 AKETSEKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS 660 Query: 661 TKASTNGKMLE 671 TKASTNGKMLE Sbjct: 661 TKASTNGKMLE 671 >gi|239755296 PREDICTED: similar to hCG1644292 [Homo sapiens] Length = 671 Score = 1369 bits (3544), Expect = 0.0 Identities = 669/671 (99%), Positives = 670/671 (99%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC Sbjct: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 Query: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT Sbjct: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 Query: 121 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 FSNLRLA HLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR Sbjct: 121 FSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 Query: 181 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 240 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP Sbjct: 181 PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 240 Query: 241 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF 300 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF Sbjct: 241 NQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLF 300 Query: 301 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR 360 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR Sbjct: 301 ADGTGLRELLKGGGHGRRLQVHRVLLEHWDDLLHLQSHSFQALGVVLLQDVQLRLGQVWR 360 Query: 361 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR 420 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR Sbjct: 361 HMASLVQGIHQAPRRSSMVMTELWLVQARMWSLPLQETECRAVWPLSAAQGSVPFSSSYR 420 Query: 421 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA 480 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA Sbjct: 421 TFSTSLALVALALSPSFSSELHLFARATTPGAALRHTATSRVVVQWGLGPGGLLAREAHA 480 Query: 481 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD 540 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD Sbjct: 481 AAPVQTRSQRRRRGPSLARLADSALNTNPRPYPIFLHCLPALSQSHATEQPEGTSEGTPD 540 Query: 541 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT 600 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT Sbjct: 541 EAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRT 600 Query: 601 AKETSEKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS 660 AKETS+KFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS Sbjct: 601 AKETSKKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETS 660 Query: 661 TKASTNGKMLE 671 TKASTNGKMLE Sbjct: 661 TKASTNGKMLE 671 >gi|126091152 cubilin [Homo sapiens] Length = 3623 Score = 457 bits (1176), Expect = e-128 Identities = 241/333 (72%), Positives = 248/333 (74%), Gaps = 69/333 (20%) Query: 1 MYLRFRSDNSPNHMGFK----------------------------------------GLS 20 MYLRFRSDNSP H+GFK GLS Sbjct: 2312 MYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLS 2371 Query: 21 RHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVR-V 79 HYLT SFEDFNLQNSSGCEKDFVEIWD HTSGNILGRYC NTIPDS DTSSNTAVVR V Sbjct: 2372 GHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFV 2431 Query: 80 WWGS---------------------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 GS QGS GT TSPNYPN NPHGRI EWRITAPEGR+IT Sbjct: 2432 TDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRIT 2491 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 L F+NLRLA H SCN+EHVIVFNGIRSNSPQLEKLCSSVNVS+EIKSSGNTMKVIFFTDG Sbjct: 2492 LMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDG 2551 Query: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238 SRPYGGFTAS+TSSEDA +CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS Sbjct: 2552 SRPYGGFTASYTSSEDA-------VCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 2604 Query: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRV 271 NPNQGNSSI IHFEDFYLESHQDCQFDVLEFRV Sbjct: 2605 NPNQGNSSISIHFEDFYLESHQDCQFDVLEFRV 2637 Score = 91.3 bits (225), Expect = 3e-18 Identities = 72/279 (25%), Positives = 120/279 (43%), Gaps = 39/279 (13%) Query: 7 SDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPD 66 S+N + + + + + +F F+L++ C D++E++D +GRYC +P Sbjct: 1301 SENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYD---GPRQMGRYCGVDLPP 1357 Query: 67 STDTSSNTAVVRV---------------WW----GSQ--GSAGTSTSPNYPNLNPHGRIY 105 T+S+ V + W+ G + G+ G+ +SP +PN P + Sbjct: 1358 PGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKEC 1417 Query: 106 EWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCS--SVNVSSEI 163 W I G I LT + + H CN + + ++ G +SP++ +LC+ S ++ Sbjct: 1418 IWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQV 1477 Query: 164 KSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDG 223 S+GN + + F TD S GF AS A GC G + P G SP Y Sbjct: 1478 SSTGNELAIRFKTDLSINGRGFNASW----QAVTGGC-----GGIFQAPSGEIHSPNYPS 1528 Query: 224 VRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262 Y N +C W + N + ++F DF LE C Sbjct: 1529 --PYRSNTDCSWVIRVDR--NHRVLLNFTDFDLEPQDSC 1563 Score = 88.6 bits (218), Expect = 2e-17 Identities = 76/271 (28%), Positives = 117/271 (43%), Gaps = 40/271 (14%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVWW 81 H + FE F+L+ C D++E++D + + LGRYC +IP S +S N+ ++ Sbjct: 968 HLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS-LGRYCGKSIPPSLTSSGNSLMLVFVT 1026 Query: 82 GSQ------------------------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQI 117 S GT TSPN+PN P+ +RIT G+ I Sbjct: 1027 DSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLI 1086 Query: 118 TLTFSNLRLAMHL-SCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 + F+N L + + ++ + + +G SP L S N+ I S N + + F + Sbjct: 1087 AVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGS-NLPPTIISHSNKLWLKFKS 1145 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT 236 D GF+A S CGG+L T G F SP Y Y + C W Sbjct: 1146 DQIDTRSGFSAYWDGSSTG--------CGGNL-TTSSGTFISPNYP--MPYYHSSECYWW 1194 Query: 237 LSNPNQGNSSIYIHFEDFYLESHQDCQFDVL 267 L + + S+ + F+DF+LE H +C D L Sbjct: 1195 LKSSH--GSAFELEFKDFHLEHHPNCTLDYL 1223 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 35/267 (13%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN-----------------TIPDSTD 69 +F LQ S ++++E+ D T +LG+ C N I S + Sbjct: 749 NFTHVELQCQSDSSQNYIEVRDGET---LLGKVCGNGTISHIKSITNSVWIRFKIDASVE 805 Query: 70 TSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAM 128 +S AV +V G + + G SP +PN+ P R W I P+ + I L F+ + Sbjct: 806 KASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGS 865 Query: 129 HLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTAS 188 C +++V + + SP+ +K C + ++ S I S N + V F S GF A Sbjct: 866 SAHCETDYVEIGSSSILGSPENKKYCGT-DIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924 Query: 189 HTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY 248 S+ED L G + G SPG+ V Y +NC W + Q N I+ Sbjct: 925 F-SAED--------LACGEILTESTGTIQSPGHPNV--YPHGINCTWHIL--VQPNHLIH 971 Query: 249 IHFEDFYLESHQDCQFDVLEFRVVASE 275 + FE F+LE H +C D LE SE Sbjct: 972 LMFETFHLEFHYNCTNDYLEVYDTDSE 998 Score = 84.0 bits (206), Expect = 4e-16 Identities = 63/269 (23%), Positives = 115/269 (42%), Gaps = 32/269 (11%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIP-------------------DS 67 SF F L++S C +DFVEI + + +G+++GRYC N+ P Sbjct: 1779 SFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSG 1838 Query: 68 TDTSSNTAVVRVWWGSQ--GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125 + T ++++ G+ G SP +P PH Y+W + + + Sbjct: 1839 SGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMD 1898 Query: 126 LAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGF 185 + +C + + +++G ++ + C + S S+GN++ F++D S GF Sbjct: 1899 IEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTES--FSSTGNSLTFHFYSDSSISGKGF 1956 Query: 186 TASHTSSEDADKV---GCCKLCGGSLPNTPEGNFT-SPGYDGVRNYSRNLNCEWTLSNPN 241 + + D V CGG L F SPG+ +YS ++C W + P Sbjct: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPD--SYSNRVDCTWLIQAP- 2013 Query: 242 QGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 +S++ ++ +ESH+ C +D L R Sbjct: 2014 --DSTVELNILSLDIESHRTCAYDSLVIR 2040 Score = 82.0 bits (201), Expect = 2e-15 Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 35/267 (13%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNI-LGRYCANTIPDSTDTSSNTAVVRVW----- 80 +F F L++ C +F++++D +S LGR+C +++P +S N ++ Sbjct: 515 TFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLR 574 Query: 81 --------WGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123 W +Q G G+ SP YP P GR W + +T TF Sbjct: 575 NGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGT 634 Query: 124 LRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183 L L H CN +++ + +G P L K C++ +V ++++G ++ F +D Sbjct: 635 LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSV-PPLQTTGPFARIHFHSDSQISDQ 693 Query: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243 GF ++ +S + CGG+ + PEG P G ++R C + + P Sbjct: 694 GFHITYLTSPSDLR------CGGNYTD-PEGELFLPELSGPFTHTR--QCVYMMKQPQ-- 742 Query: 244 NSSIYIHFEDFYLESHQDCQFDVLEFR 270 I I+F L+ D + +E R Sbjct: 743 GEQIQINFTHVELQCQSDSSQNYIEVR 769 Score = 81.6 bits (200), Expect = 2e-15 Identities = 69/258 (26%), Positives = 106/258 (41%), Gaps = 45/258 (17%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILG-----RYCANTIPDSTDTSSNTAVVRVWW 81 +F F + +S+ CE D+VEI S +ILG +YC IP + N V Sbjct: 857 NFTVFEIGSSAHCETDYVEIG----SSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVK 912 Query: 82 GSQG----------------------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITL 119 S S GT SP +PN+ PHG W I I L Sbjct: 913 SSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHL 972 Query: 120 TFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGS 179 F L H +C ++++ V++ + L + C ++ + SSGN++ ++F TD Sbjct: 973 MFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGK-SIPPSLTSSGNSLMLVFVTDSD 1029 Query: 180 RPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSN 239 Y GF ++ + A C + L G FTSP + NY N C + ++ Sbjct: 1030 LAYEGFLINYEAISAA--TACLQDYTDDL-----GTFTSPNFP--NNYPNNWECIYRIT- 1079 Query: 240 PNQGNSSIYIHFEDFYLE 257 + I +HF +F LE Sbjct: 1080 -VRTGQLIAVHFTNFSLE 1096 Score = 80.5 bits (197), Expect = 5e-15 Identities = 71/249 (28%), Positives = 109/249 (43%), Gaps = 39/249 (15%) Query: 9 NSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN---TIP 65 ++PN G +S H FEDF L++ C+ D +E G ++ R C T+P Sbjct: 2604 SNPNQ-GNSSISIH-----FEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLP 2657 Query: 66 DSTDTS-------SNTAVVRVWWGSQ-----------GSAGTSTSPNYPNLNPHGRIYEW 107 S +N V + + ++ G +G TSPNYPN Sbjct: 2658 LVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSS 2717 Query: 108 RITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSG 167 + AP+G ITLTFS+ + H +C + V V NG SP + + C + N + I+S Sbjct: 2718 LLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRT-IQSGS 2776 Query: 168 NTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNY 227 N + V F +D S GGF A+ + +GC G + ++ G SP + +N+ Sbjct: 2777 NQLVVTFNSDHSLQGGGFYATW----NTQTLGC-----GGIFHSDNGTIRSPHWP--QNF 2825 Query: 228 SRNLNCEWT 236 N C WT Sbjct: 2826 PENSRCSWT 2834 Score = 79.0 bits (193), Expect = 1e-14 Identities = 67/264 (25%), Positives = 114/264 (43%), Gaps = 43/264 (16%) Query: 28 FEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWW--GSQ 84 F+DF+L++ C D++ ++D +S + +L + C + P +S ++ +++ G Q Sbjct: 1207 FKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQ 1266 Query: 85 GSA-------------------GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125 G G S YPN + W I A G + TF Sbjct: 1267 GRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD 1326 Query: 126 LAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG-SRPYGG 184 L H++C+++++ +++G R Q+ + C V++ ++ + ++V+ TDG R G Sbjct: 1327 LEHHINCSTDYLELYDGPR----QMGRYCG-VDLPPPGSTTSSKLQVLLLTDGVGRREKG 1381 Query: 185 FTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGN 244 F CGG L G+F+SPG+ Y N C W + Sbjct: 1382 FQMQWFVYG----------CGGELSGAT-GSFSSPGFPN--RYPPNKECIWYIRT--DPG 1426 Query: 245 SSIYIHFEDFYLESHQDCQFDVLE 268 SSI + DF +E H C FDVLE Sbjct: 1427 SSIQLTIHDFDVEYHSRCNFDVLE 1450 Score = 78.6 bits (192), Expect = 2e-14 Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 13/187 (6%) Query: 86 SAGTSTSPNYPNLN-PHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIR 144 S+G TSP Y + P+ + IT + + I L FS+ + SC+ +++ +++G Sbjct: 3044 SSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGAN 3103 Query: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204 ++ P L K C S +KSS N+M ++F TD + G+ S + +G + C Sbjct: 3104 TSDPLLGKFCGSKR-PPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQT-----LGPQQGC 3157 Query: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLE---SHQD 261 GG L + F SP D Y +NLNC W + P N I++ F F LE + Q Sbjct: 3158 GGYLTGS-NNTFASPDSDSNGMYDKNLNCVWIIIAP--VNKVIHLTFNTFALEAASTRQR 3214 Query: 262 CQFDVLE 268 C +D ++ Sbjct: 3215 CLYDYVK 3221 Score = 77.8 bits (190), Expect = 3e-14 Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 39/305 (12%) Query: 28 FEDFNLQNSSG-CEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRV------ 79 F +F+L+ + G DF+EI D + +LG + + +P + + SN ++ Sbjct: 1090 FTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQID 1149 Query: 80 --------WWGSQG--------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123 W GS S+GT SPNYP H W + + G L F + Sbjct: 1150 TRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKD 1209 Query: 124 LRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183 L H +C +++ V++G SNS L +LC I+SSG++M + TD + Sbjct: 1210 FHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGD-EKPPLIRSSGDSMFIKLRTDEGQQGR 1268 Query: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243 GF A + + C+ + N G S GY YS N +C WT+ G Sbjct: 1269 GFKAEYRQT--------CE--NVVIVNQTYGILESIGYP--NPYSENQHCNWTI-RATTG 1315 Query: 244 NSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLFADG 303 N+ Y F F LE H +C D LE + + + + L+ L DG Sbjct: 1316 NTVNYT-FLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDG 1374 Query: 304 TGLRE 308 G RE Sbjct: 1375 VGRRE 1379 Score = 77.0 bits (188), Expect = 5e-14 Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 49/274 (17%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRVW 80 +++T SF F L+ S+ C +DFVEI D H + GRYC +P + S+ +R Sbjct: 1658 NHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFV 1717 Query: 81 WGSQGSAG----------------------TSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 S SAG SP YP++ P W I + G ++ Sbjct: 1718 SDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQ 1777 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS---VNVSSEIKSSGNTMKVIFF 175 L+F + +L C+ + V + G + + + C + +N SS + G+T+ V F Sbjct: 1778 LSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV---GHTLWVRFI 1833 Query: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235 +DGS GF A+ K+ G G SP + NY N N +W Sbjct: 1834 SDGSGSGTGFQATF-----------MKIFGNDNIVGTHGKVASPFWP--ENYPHNSNYQW 1880 Query: 236 TLSNPNQGNSSIYIH--FEDFYLESHQDCQFDVL 267 T++ N+S +H + +E Q+C +D L Sbjct: 1881 TVN----VNASHVVHGRILEMDIEEIQNCYYDKL 1910 Score = 77.0 bits (188), Expect = 5e-14 Identities = 62/186 (33%), Positives = 93/186 (50%), Gaps = 20/186 (10%) Query: 86 SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN-LRLAMHLSCNSEHVIVFNGIR 144 SAG TSPN+P+ P W + AP +I L F + + + +C S ++ + +G+ Sbjct: 2228 SAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVD 2287 Query: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204 S++P L K C + SS+ SSG M + F +D S + GF A ++ ++ C Sbjct: 2288 SDAPILSKFCGTSLPSSQ-WSSGEVMYLRFRSDNSPTHVGFKAKYSIAQ----------C 2336 Query: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY--IHFEDFYLESHQDC 262 GG +P G S G+ + Y NL CEW L QG S Y I FEDF L++ C Sbjct: 2337 GGRVPG-QSGVVESIGHPTL-PYRDNLFCEWHL----QGLSGHYLTISFEDFNLQNSSGC 2390 Query: 263 QFDVLE 268 + D +E Sbjct: 2391 EKDFVE 2396 Score = 73.9 bits (180), Expect = 4e-13 Identities = 53/175 (30%), Positives = 81/175 (46%), Gaps = 14/175 (8%) Query: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNS 147 G SP +P+ + + +TAP+ I+L F +L + + C ++ + V NG SNS Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463 Query: 148 PQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGS 207 P L K C ++ + + + S N + + F +D G+ TSS CGG+ Sbjct: 3464 PLLGKYCGTL-LPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG--------CGGT 3514 Query: 208 LPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262 L G+FTSPGY G Y N CEW L P + I+F ++ DC Sbjct: 3515 LYG-DRGSFTSPGYPG--TYPNNTYCEWVLVAP--AGRLVTINFYFISIDDPGDC 3564 Score = 73.2 bits (178), Expect = 7e-13 Identities = 45/187 (24%), Positives = 80/187 (42%), Gaps = 23/187 (12%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78 H ++ F ++NS C DF+E+ + S + +LG+YC +P+ + +N +R Sbjct: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490 Query: 79 ------------VWWGSQ--------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 +W S G G+ TSP YP P+ EW + AP GR +T Sbjct: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVT 3550 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 + F + + C ++ +++G ++SP C + +S N + + F D Sbjct: 3551 INFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADY 3610 Query: 179 SRPYGGF 185 +R F Sbjct: 3611 ARRPSAF 3617 Score = 72.4 bits (176), Expect = 1e-12 Identities = 65/270 (24%), Positives = 106/270 (39%), Gaps = 48/270 (17%) Query: 27 SFEDFNLQNSSGCEKDFVEIW---DYHTSGNILGRYCANTIPDS---------------- 67 + DF+++ S C D +EI+ D+H+ + + C P++ Sbjct: 1432 TIHDFDVEYHSRCNFDVLEIYGGPDFHSPR--IAQLCTQRSPENPMQVSSTGNELAIRFK 1489 Query: 68 TDTSSNTAVVRVWWGS---------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 TD S N W + Q +G SPNYP+ W I ++ Sbjct: 1490 TDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVL 1549 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 L F++ L SC ++ ++G+ S +L + C +++ I SSGN++ + F + Sbjct: 1550 LNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGP 1605 Query: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238 SR GF A + CGG + + +SP + NY N NC W + Sbjct: 1606 SRQNRGFRAQFRQA-----------CGGHILTSSFDTVSSPRFPA--NYPNNQNCSWIIQ 1652 Query: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 N I + F F LE C D +E Sbjct: 1653 AQPPLN-HITLSFTHFELERSTTCARDFVE 1681 Score = 65.9 bits (159), Expect = 1e-10 Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 16/165 (9%) Query: 107 WRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSS 166 W I G+ + +TF+ RL +C E + V++G S++ QL + C S ++ E+ SS Sbjct: 502 WVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS-SLPHELLSS 560 Query: 167 GNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRN 226 N + +++ R GFT + + CGG L P G+ SPGY G N Sbjct: 561 DNALYFHLYSEHLRNGRGFTVRWETQQPE--------CGGILTG-PYGSIKSPGYPG--N 609 Query: 227 YSRNLNCEW-TLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 Y +C W +++P + + F LE H DC D LE R Sbjct: 610 YPPGRDCVWIVVTSP---DLLVTFTFGTLSLEHHDDCNKDYLEIR 651 Score = 62.0 bits (149), Expect = 2e-09 Identities = 66/264 (25%), Positives = 107/264 (40%), Gaps = 46/264 (17%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78 H +T +F DF+++ + C D V + + + + I+G+YC N+ P + + SN VV Sbjct: 2725 HTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFN 2784 Query: 79 -----------VWWGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 W +Q GT SP++P P W + + + Sbjct: 2785 SDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLE 2844 Query: 119 LTFSN--LRLAMHLSCNSEHVIVFNGIRS-NSPQLEKLCSSVNVSSEIKSSGNTMKVIFF 175 ++F N L + C + V V+ G + L C +V I S NT +F Sbjct: 2845 ISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPS-NTFTAVFQ 2903 Query: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235 + P GF+AS S CG + P G SP Y + Y N+NC + Sbjct: 2904 SQ-EAPAQGFSASFVSR-----------CGSNFTG-PSGYIISPNYP--KQYDNNMNCTY 2948 Query: 236 TL-SNPNQGNSSIYIHFEDFYLES 258 + +NP S + + F F+LE+ Sbjct: 2949 VIEANP---LSVVLLTFVSFHLEA 2969 Score = 61.2 bits (147), Expect = 3e-09 Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 18/161 (11%) Query: 92 SPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLE 151 SP +P+ + W I AP+ + L +L + H +C + +++ +G + + QL Sbjct: 1993 SPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLA 2051 Query: 152 KLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT 211 LC + I+S+G M + F +D S GF AS S CGG L + Sbjct: 2052 VLCGR-EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKS-----------CGGYL-HA 2098 Query: 212 PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFE 252 G TSP Y Y NLNC W + Q +I +HFE Sbjct: 2099 DRGIITSPKYP--ETYPSNLNCSWHVL--VQSGLTIAVHFE 2135 Score = 60.8 bits (146), Expect = 4e-09 Identities = 72/292 (24%), Positives = 119/292 (40%), Gaps = 48/292 (16%) Query: 28 FEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPDSTDTSSNTAVV--------- 77 F DF++ S+ C D++ I+D +TS +LG++C + P + +S+N+ ++ Sbjct: 3080 FSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQT 3139 Query: 78 -RVWWGS--------QGSAGTSTSPNYPNLNP---HGRIYE------WRITAPEGRQITL 119 + W S QG G T N +P +Y+ W I AP + I L Sbjct: 3140 AKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHL 3199 Query: 120 TFSNLRL---AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 TF+ L + C ++V +++G N+ C S V + SSGN + V F + Sbjct: 3200 TFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGS-TVPAPFISSGNFLTVQFIS 3258 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT-PEGNFTSP-GYDGVRNYSRNLNCE 234 D + GF A++T + CGG+ T N +SP D +S C Sbjct: 3259 DLTLEREGFNATYTIMD--------MPCGGTYNATWTPQNISSPNSSDPDVPFS---ICT 3307 Query: 235 WTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISR 286 W + +P I + + QDC + L+ + H F R Sbjct: 3308 WVIDSPPHQQVKITVWALQL---TSQDCTQNYLQLQDSPQGHGNSRFQFCGR 3356 Score = 59.7 bits (143), Expect = 9e-09 Identities = 67/270 (24%), Positives = 107/270 (39%), Gaps = 47/270 (17%) Query: 24 LTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWWG 82 +T +F +L++ C KD++EI D + +LG++C T+ A + Sbjct: 628 VTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSD 687 Query: 83 SQGS-----------------AGTSTSPN----YPNLN---PHGRIYEWRITAPEGRQIT 118 SQ S G T P P L+ H R + + P+G QI Sbjct: 688 SQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQ 747 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 + F++ + L C S+ + +R L K+C + + S IKS N++ + F D Sbjct: 748 INFTH----VELQCQSDSSQNYIEVRDGETLLGKVCGNGTI-SHIKSITNSVWIRFKIDA 802 Query: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238 S F A + + CG L T EG SP + V Y C WT+ Sbjct: 803 SVEKASFRAVYQVA-----------CGDEL--TGEGVIRSPFFPNV--YPGERTCRWTIH 847 Query: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 P + I ++F F + S C+ D +E Sbjct: 848 QPQ--SQVILLNFTVFEIGSSAHCETDYVE 875 Score = 54.3 bits (129), Expect = 4e-07 Identities = 56/196 (28%), Positives = 82/196 (41%), Gaps = 26/196 (13%) Query: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMH--LSCN-SEHVIVFNGIR 144 G TSP YP P W + G I + F + SCN +++++ NG Sbjct: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160 Query: 145 SNSPQL------EKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKV 198 SP L C S + SS + +S N M V F +D S GF + + A Sbjct: 2161 ICSPPLGPPGGNGHFCGS-HASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLA--- 2216 Query: 199 GCCKLCGGSL---PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFED-F 254 CGG++ G TSP + NY + +C W L+ P + + I + FED F Sbjct: 2217 -----CGGNVYIHDADSAGYVTSPNHP--HNYPPHADCIWILAAPPE--TRIQLQFEDRF 2267 Query: 255 YLESHQDCQFDVLEFR 270 +E +C + LE R Sbjct: 2268 DIEVTPNCTSNYLELR 2283 Score = 48.1 bits (113), Expect = 3e-05 Identities = 47/187 (25%), Positives = 79/187 (42%), Gaps = 20/187 (10%) Query: 88 GTSTSPNYPNLNPHGRIY--EWRITAPE--GRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 G TSP Y + + R EW ++ P I++ F + L H C + V+ F Sbjct: 2580 GNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD-VLEFRVG 2638 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 ++ P + +LC + + + + + F T+ + GF A ++ ++ Sbjct: 2639 DADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD---------- 2688 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + G TSP Y Y +C L P QG++ I + F DF +E H C Sbjct: 2689 CGG-IQIGDSGVITSPNYPNA--YDSLTHCSSLLEAP-QGHT-ITLTFSDFDIEPHTTCA 2743 Query: 264 FDVLEFR 270 +D + R Sbjct: 2744 WDSVTVR 2750 >gi|222537750 ankyrin repeat domain 30B [Homo sapiens] Length = 1392 Score = 241 bits (614), Expect = 2e-63 Identities = 119/145 (82%), Positives = 127/145 (87%) Query: 522 LSQSHATEQPEGTSEGTPDEAAPLAERTPDMAESLVEKPPDEAAPLVEGTADKIQCLGKA 581 L ++ PEGTS GTPDEAAPLAERTPD AESL+EK PDEAA LVEGT+ KIQCLGKA Sbjct: 264 LPKNPQNTNPEGTSTGTPDEAAPLAERTPDTAESLLEKTPDEAARLVEGTSAKIQCLGKA 323 Query: 582 TSGKFEQSAEETPKKIMRTAKETSEKFAWPAKERPRKITWEEKETSVKTECVAGVIPNKT 641 TSGKFEQS EETP+KI+R KETSEKF+WPAKER RKITWEEKETSVKTECVAGV PNKT Sbjct: 324 TSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEEKETSVKTECVAGVTPNKT 383 Query: 642 EVLEKGTSEMLTCPTKETSTKASTN 666 EVLEKGTS M+ CPTKETSTKASTN Sbjct: 384 EVLEKGTSNMIACPTKETSTKASTN 408 >gi|115495445 ankyrin repeat domain 30A [Homo sapiens] Length = 1341 Score = 198 bits (503), Expect = 2e-50 Identities = 113/201 (56%), Positives = 123/201 (61%), Gaps = 56/201 (27%) Query: 522 LSQSHATEQPEGTSEGTPDEAAPLAERTPDMAESLVEKPPDEAAPLVE------------ 569 LS++H PEGTS GTPDEAAPLAERTPD AESLVEK PDEAAPLVE Sbjct: 208 LSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDEAAPLVERTPDTAESLVEK 267 Query: 570 ----------GTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP-------- 611 GT+DKIQCL KATSGKFEQSAEETP++I AKETSEKF WP Sbjct: 268 TPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREITSPAKETSEKFTWPAKGRPRKI 327 Query: 612 --------------------------AKERPRKITWEEKETSVKTECVAGVIPNKTEVLE 645 AK RPRKI WE+KET VKT CVA V NKT+VLE Sbjct: 328 AWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKETPVKTGCVARVTSNKTKVLE 387 Query: 646 KGTSEMLTCPTKETSTKASTN 666 KG S+M+ CPTKE+STKAS N Sbjct: 388 KGRSKMIACPTKESSTKASAN 408 >gi|239757619 PREDICTED: similar to hCG1644292 [Homo sapiens] Length = 118 Score = 186 bits (473), Expect = 5e-47 Identities = 94/120 (78%), Positives = 105/120 (87%), Gaps = 2/120 (1%) Query: 552 MAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP 611 MAESLVE+ PDEAAPLVEGT+D++QCLGK SGK EQSA ETP+KI R KETSEKFAWP Sbjct: 1 MAESLVERTPDEAAPLVEGTSDEVQCLGKTISGKTEQSARETPRKITRPVKETSEKFAWP 60 Query: 612 AKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETSTKASTNGKMLE 671 +ERP K TWEEKETSVKTECVAGV NK EVLE+GT++M+TCPTK T+TKASTNGKMLE Sbjct: 61 -QERPTKTTWEEKETSVKTECVAGVTSNKIEVLEEGTAKMITCPTK-TATKASTNGKMLE 118 >gi|239752110 PREDICTED: hypothetical protein XP_002348113 [Homo sapiens] Length = 118 Score = 186 bits (473), Expect = 5e-47 Identities = 94/120 (78%), Positives = 105/120 (87%), Gaps = 2/120 (1%) Query: 552 MAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP 611 MAESLVE+ PDEAAPLVEGT+D++QCLGK SGK EQSA ETP+KI R KETSEKFAWP Sbjct: 1 MAESLVERTPDEAAPLVEGTSDEVQCLGKTISGKTEQSARETPRKITRPVKETSEKFAWP 60 Query: 612 AKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETSTKASTNGKMLE 671 +ERP K TWEEKETSVKTECVAGV NK EVLE+GT++M+TCPTK T+TKASTNGKMLE Sbjct: 61 -QERPTKTTWEEKETSVKTECVAGVTSNKIEVLEEGTAKMITCPTK-TATKASTNGKMLE 118 >gi|239743843 PREDICTED: hypothetical protein XP_002342968 [Homo sapiens] Length = 139 Score = 171 bits (433), Expect = 2e-42 Identities = 84/111 (75%), Positives = 95/111 (85%), Gaps = 1/111 (0%) Query: 552 MAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP 611 MAESLVE+ PDEAAPLVEGT+D++QCLGK SGK E+SA ETP+KI R KETSEKFAWP Sbjct: 1 MAESLVERTPDEAAPLVEGTSDEVQCLGKTISGKIEESAGETPRKITRPVKETSEKFAWP 60 Query: 612 AKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETSTK 662 +ERP K TWEEKETSVKTECVAGV NKTEVLE+GTS+M+TCPTK+ K Sbjct: 61 -QERPTKTTWEEKETSVKTECVAGVTSNKTEVLEEGTSKMITCPTKKQLQK 110 >gi|239743812 PREDICTED: similar to hCG1644292 [Homo sapiens] Length = 139 Score = 171 bits (433), Expect = 2e-42 Identities = 84/111 (75%), Positives = 95/111 (85%), Gaps = 1/111 (0%) Query: 552 MAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP 611 MAESLVE+ PDEAAPLVEGT+D++QCLGK SGK E+SA ETP+KI R KETSEKFAWP Sbjct: 1 MAESLVERTPDEAAPLVEGTSDEVQCLGKTISGKIEESAGETPRKITRPVKETSEKFAWP 60 Query: 612 AKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETSTK 662 +ERP K TWEEKETSVKTECVAGV NKTEVLE+GTS+M+TCPTK+ K Sbjct: 61 -QERPTKTTWEEKETSVKTECVAGVTSNKTEVLEEGTSKMITCPTKKQLQK 110 >gi|239758143 PREDICTED: similar to hCG1644292 [Homo sapiens] Length = 115 Score = 165 bits (418), Expect = 1e-40 Identities = 82/111 (73%), Positives = 93/111 (83%), Gaps = 1/111 (0%) Query: 552 MAESLVEKPPDEAAPLVEGTADKIQCLGKATSGKFEQSAEETPKKIMRTAKETSEKFAWP 611 MAESLVE+ EAAPLVEGT+D++QCLGK SGK E+SA ETP+KI R KETSEKFAWP Sbjct: 1 MAESLVERTQHEAAPLVEGTSDEVQCLGKTISGKIEESAGETPRKITRPVKETSEKFAWP 60 Query: 612 AKERPRKITWEEKETSVKTECVAGVIPNKTEVLEKGTSEMLTCPTKETSTK 662 +ERP K TWEEKETSVKTECVAGV NKTEVLE+GTS+M+TCPTK+ K Sbjct: 61 -QERPTKTTWEEKETSVKTECVAGVTSNKTEVLEEGTSKMITCPTKKQLQK 110 >gi|22547221 tolloid-like 1 [Homo sapiens] Length = 1013 Score = 102 bits (253), Expect = 1e-21 Identities = 76/272 (27%), Positives = 123/272 (45%), Gaps = 33/272 (12%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRY- 59 M + F+SDN+ + GFK H+ ++ +D +++ GC+ + V N +G Y Sbjct: 708 MRIEFKSDNTVSKKGFKA---HFFSD--KDECSKDNGGCQHECV---------NTMGSYM 753 Query: 60 --CANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQI 117 C N D + +G TSPN+P+ P + W I+A G +I Sbjct: 754 CQCRNGFV-LHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812 Query: 118 TLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTD 177 L FS + H C +H+ VF+G SP L +LC + + + ++GN M V F +D Sbjct: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRFVSD 871 Query: 178 GSRPYGGFTASHTSSEDADKVGCCKLCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWT 236 S GF A+H++ CGG L + + S G NY ++CEW Sbjct: 872 ASVQRKGFQATHSTE-----------CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWL 920 Query: 237 LSNPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 L ++ S + + F+ F +E DC +D +E Sbjct: 921 L--VSERGSRLELSFQTFEVEEEADCGYDYVE 950 Score = 101 bits (252), Expect = 2e-21 Identities = 82/293 (27%), Positives = 129/293 (44%), Gaps = 56/293 (19%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPD---STDT--------SSN- 73 +F +L SS C D++E+ D Y +LGR+C + +P+ STD+ SSN Sbjct: 390 NFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNW 449 Query: 74 -----TAVVRVWWGSQ--GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL 126 AV G + + G SPNYP+ + W+IT E + LTF + + Sbjct: 450 VGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEI 509 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 H +C +++ V +G NSP + + C + +I+S+ NT+ + F +DG+ GF Sbjct: 510 ERHDNCAYDYLEVRDGTSENSPLIGRFCG-YDKPEDIRSTSNTLWMKFVSDGTVNKAGFA 568 Query: 187 ASHTSSED----ADKVGC---------------------------CKLCGGSLPNTPEGN 215 A+ ED D+ GC C+ G L G Sbjct: 569 ANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGT 628 Query: 216 FTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 T+PG+ + Y N NC W + P Q I + FE F LE ++ C++D +E Sbjct: 629 ITTPGWP--KEYPPNKNCVWQVVAPTQ--YRISVKFEFFELEGNEVCKYDYVE 677 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/233 (26%), Positives = 95/233 (40%), Gaps = 40/233 (17%) Query: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNS 147 GT T+P +P P + W++ AP +I++ F L + C ++V +++G+ S S Sbjct: 627 GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES 686 Query: 148 PQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSED---ADKVGCCKLC 204 K C + V I S N M++ F +D + GF A S +D D GC C Sbjct: 687 KLHGKFCGA-EVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHEC 745 Query: 205 GGSLP----------------------------NTPEGNFTSPGYDGVRNYSRNLNCEWT 236 ++ ++P G TSP + Y C W Sbjct: 746 VNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPD--KYPSRKECTWE 803 Query: 237 LSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSG 289 +S I + F +F +E HQ+C +D LE V E K P ++ RL G Sbjct: 804 IS--ATPGHRIKLAFSEFEIEQHQECAYDHLE--VFDGETEKSP--ILGRLCG 850 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/209 (25%), Positives = 90/209 (43%), Gaps = 21/209 (10%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 Q S G +SP +PN P WR++ G +I L F+ + L C +++ V +G Sbjct: 354 QESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGY 413 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 SP L + C + + S+ + M + F + + GF A + + + Sbjct: 414 WRKSPLLGRFCGD-KLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-----------I 461 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + EG SP Y +Y C W ++ + + + F+ F +E H +C Sbjct: 462 CGGEIRKN-EGQIQSPNYPD--DYRPMKECVWKITVSE--SYHVGLTFQSFEIERHDNCA 516 Query: 264 FDVLEFRVVASEHWKVPFSLISRLSGWSE 292 +D LE R SE+ LI R G+ + Sbjct: 517 YDYLEVRDGTSEN----SPLIGRFCGYDK 541 Score = 60.8 bits (146), Expect = 4e-09 Identities = 48/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVW 80 H + +F +F ++ C D +E++D T + ILGR C N IPD + N VR Sbjct: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869 Query: 81 W-------GSQGSAGTS---------------TSPNYPNLNPHGRI-YEWRITAPEGRQI 117 G Q + T + + + N G++ EW + + G ++ Sbjct: 870 SDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929 Query: 118 TLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTD 177 L+F + C ++V +F+G+ S + L + C S EI S G+++ + F TD Sbjct: 930 ELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS-GPPEEIYSIGDSVLIHFHTD 988 Query: 178 GSRPYGGFTASHTS 191 + GF + S Sbjct: 989 DTINKKGFHIRYKS 1002 >gi|6912724 tolloid-like 2 [Homo sapiens] Length = 1015 Score = 96.7 bits (239), Expect = 6e-20 Identities = 84/296 (28%), Positives = 124/296 (41%), Gaps = 58/296 (19%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPD---STDT-------SSNTA 75 +F +L S C D+VE+ D Y +LGR+C + IP+ STD+ SS+ Sbjct: 392 NFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNI 451 Query: 76 VVRVWWGSQGS---------AGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL 126 + + ++ + + AG SPNYP+ + WRIT EG + LTF + Sbjct: 452 LGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEI 511 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 H SC +++ V +G S + C ++KSS N + + F +DGS GF Sbjct: 512 ERHDSCAYDYLEVRDGPTEESALIGHFC-GYEKPEDVKSSSNRLWMKFVSDGSINKAGFA 570 Query: 187 ASHTSSED--------------------------------ADKVGCCKLCGGSLPNTPEG 214 A+ D ADK C CGG + G Sbjct: 571 ANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKL-NG 629 Query: 215 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 TSPG+ + Y N NC W + P Q I + FE F LE + C++D +E R Sbjct: 630 TITSPGWP--KEYPTNKNCVWQVVAPAQ--YRISLQFEVFELEGNDVCKYDFVEVR 681 Score = 88.2 bits (217), Expect = 2e-17 Identities = 65/269 (24%), Positives = 116/269 (43%), Gaps = 27/269 (10%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 M + F+SDN+ + GF+ H+ ++ +D +++ GC+ + V + + G + Sbjct: 710 MRVEFKSDNTVSKRGFRA---HFFSD--KDECAKDNGGCQHECVNTFGSYLCRCRNGYWL 764 Query: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 D + + V GT SPN+P+ P R W I++ G ++ LT Sbjct: 765 HENGHDCKEAGCAHKISSV-------EGTLASPNWPDKYPSRRECTWNISSTAGHRVKLT 817 Query: 121 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 F+ + H C +H+ +++G S +P L + C S + +SG++M + F++D S Sbjct: 818 FNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTV-ASGSSMFLRFYSDASV 876 Query: 181 PYGGFTASHTSSEDADKVGCCKLCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSN 239 GF A H++ CGG L S G NY C+W + Sbjct: 877 QRKGFQAVHSTE-----------CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVI-- 923 Query: 240 PNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 + + + F F +E DC +D +E Sbjct: 924 VAEDGYGVELTFRTFEVEEEADCGYDYME 952 Score = 70.1 bits (170), Expect = 6e-12 Identities = 73/301 (24%), Positives = 115/301 (38%), Gaps = 52/301 (17%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 ++++F SD S N GF ++ + + GCE H N LG Y Sbjct: 554 LWMKFVSDGSINKAGFAA----NFFKEVDECSWPDHGGCE---------HRCVNTLGSYK 600 Query: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSA--GTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 P + +++ + V G + GT TSP +P P + W++ AP +I+ Sbjct: 601 CACDP-GYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRIS 659 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 L F L + C + V V +G+ ++ + C S I S N M+V F +D Sbjct: 660 LQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGS-ETPEVITSQSNNMRVEFKSDN 718 Query: 179 SRPYGGFTASHTSSED---ADKVGC---------------------------CKLCG-GS 207 + GF A S +D D GC CK G Sbjct: 719 TVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAH 778 Query: 208 LPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVL 267 ++ EG SP + Y C W +S + + + F +F +E HQ+C +D L Sbjct: 779 KISSVEGTLASPNWPD--KYPSRRECTWNIS--STAGHRVKLTFNEFEIEQHQECAYDHL 834 Query: 268 E 268 E Sbjct: 835 E 835 Score = 68.2 bits (165), Expect = 2e-11 Identities = 51/199 (25%), Positives = 88/199 (44%), Gaps = 25/199 (12%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTS-GNILGRYCANTIPDSTDTSSNTAVVRVW 80 H + +F +F ++ C D +E++D S ILGR+C + PD T S ++ +R + Sbjct: 812 HRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFY 871 Query: 81 -----------------WGSQGSAGTSTSPNYP------NLNPHGRIYEWRITAPEGRQI 117 G + A T Y N P +W I A +G + Sbjct: 872 SDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGV 931 Query: 118 TLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTD 177 LTF + C +++ ++G S++P+L + C S EI S+G+++ + F TD Sbjct: 932 ELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGS-GPLEEIYSAGDSLMIRFRTD 990 Query: 178 GSRPYGGFTASHTSSEDAD 196 + GF A +TS++ D Sbjct: 991 DTINKKGFHARYTSTKFQD 1009 Score = 63.5 bits (153), Expect = 6e-10 Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 17/187 (9%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 Q + G ++P +PN P WRI+ G +I L F+++ L C ++V V +G Sbjct: 356 QDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGY 415 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 +P L + C + + S+ + + V F + + GF A++ ++ Sbjct: 416 WRKAPLLGRFCGD-KIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT----------- 463 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + N G SP Y +Y + C W ++ + + F+ F +E H C Sbjct: 464 CGGDM-NKDAGQIQSPNYPD--DYRPSKECVWRITVSE--GFHVGLTFQAFEIERHDSCA 518 Query: 264 FDVLEFR 270 +D LE R Sbjct: 519 YDYLEVR 525 >gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo sapiens] Length = 986 Score = 93.6 bits (231), Expect = 5e-19 Identities = 67/269 (24%), Positives = 123/269 (45%), Gaps = 27/269 (10%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYC 60 M + F+SDN+ + GFK H+ ++ +D +++ GC++D V + + G Sbjct: 681 MRVEFKSDNTVSKKGFKA---HFFSD--KDECSKDNGGCQQDCVNTFGSYECQCRSGFVL 735 Query: 61 ANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLT 120 + D + + V ++GT TSPN+P+ P + W I++ G ++ LT Sbjct: 736 HDNKHDCKEAGCDHKVT-------STSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLT 788 Query: 121 FSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSR 180 F + + C +H+ VF+G + +P L + C S + ++G+ M + F++D S Sbjct: 789 FMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGS-KKPEPVLATGSRMFLRFYSDNSV 847 Query: 181 PYGGFTASHTSSEDADKVGCCKLCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSN 239 GF ASH + CGG + + + S G NY ++CEW + Sbjct: 848 QRKGFQASHATE-----------CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVI-- 894 Query: 240 PNQGNSSIYIHFEDFYLESHQDCQFDVLE 268 + + + F+ F +E DC +D +E Sbjct: 895 VAEEGYGVELVFQTFEVEEETDCGYDYME 923 Score = 86.3 bits (212), Expect = 9e-17 Identities = 80/296 (27%), Positives = 121/296 (40%), Gaps = 58/296 (19%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPD---STDT--------SSNT 74 +F +L S C D+VE+ D + + GR+C + +P+ STD+ SSN Sbjct: 363 NFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNW 422 Query: 75 ------AVVRVWWGS--QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL 126 AV G + G SPNYP+ ++ WRI EG + LTF + + Sbjct: 423 VGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 H SC +++ V +G +S + + C +IKS+ + + + F +DGS GF Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFA 541 Query: 187 ASHTSSED--------------------------------ADKVGCCKLCGGSLPNTPEG 214 + D DK C CGG L G Sbjct: 542 VNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NG 600 Query: 215 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 + TSPG+ + Y N NC W L P Q I + F+ F E + C++D +E R Sbjct: 601 SITSPGWP--KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVR 652 Score = 62.4 bits (150), Expect = 1e-09 Identities = 47/199 (23%), Positives = 86/199 (43%), Gaps = 25/199 (12%) Query: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTS-GNILGRYCANTIPDSTDTSSNTAVVRVW 80 H + +F + ++++ C D +E++D + +LGR+C + P+ + + +R + Sbjct: 783 HRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFY 842 Query: 81 -----------------WGSQGSAGTSTSPNYP------NLNPHGRIYEWRITAPEGRQI 117 G Q A T Y N P G EW I A EG + Sbjct: 843 SDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGV 902 Query: 118 TLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTD 177 L F + C +++ +F+G S +P+L + C S E+ S+G+++ V F +D Sbjct: 903 ELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGS-GPPEEVYSAGDSVLVKFHSD 961 Query: 178 GSRPYGGFTASHTSSEDAD 196 + GF +TS++ D Sbjct: 962 DTITKKGFHLRYTSTKFQD 980 Score = 61.6 bits (148), Expect = 2e-09 Identities = 56/209 (26%), Positives = 88/209 (42%), Gaps = 21/209 (10%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 Q S G +SP YPN WRI+ G +I L F++L L C ++V V +G Sbjct: 327 QDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGF 386 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 +P + C S + I S+ + + V F + + GF A + + + Sbjct: 387 WRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-----------I 434 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + G+ SP Y +Y + C W + + + F+ F +E H C Sbjct: 435 CGGDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCA 489 Query: 264 FDVLEFRVVASEHWKVPFSLISRLSGWSE 292 +D LE R SE +LI R G+ + Sbjct: 490 YDYLEVRDGHSE----SSTLIGRYCGYEK 514 Score = 58.2 bits (139), Expect = 2e-08 Identities = 73/303 (24%), Positives = 109/303 (35%), Gaps = 56/303 (18%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFN---LQNSSGCEKDFVEIWDYHTSGNILG 57 ++L+F SD S N GF N F++ + N GCE+ + N LG Sbjct: 525 LWLKFVSDGSINKAGFA-------VNFFKEVDECSRPNRGGCEQRCL---------NTLG 568 Query: 58 RYCANTIPDSTDTSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 Y + P G G+ TSP +P P + W++ AP + Sbjct: 569 SYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYR 628 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 I+L F + C + V V +G+ ++S K C S I S N M+V F + Sbjct: 629 ISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-EKPEVITSQYNNMRVEFKS 687 Query: 177 DGSRPYGGFTASHTSSED---ADKVGC---------------------------CKLCG- 205 D + GF A S +D D GC CK G Sbjct: 688 DNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGC 747 Query: 206 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFD 265 + G TSP + Y C W +S + + + F + +ES +C +D Sbjct: 748 DHKVTSTSGTITSPNWPD--KYPSKKECTWAIS--STPGHRVKLTFMEMDIESQPECAYD 803 Query: 266 VLE 268 LE Sbjct: 804 HLE 806 >gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo sapiens] Length = 730 Score = 86.3 bits (212), Expect = 9e-17 Identities = 80/296 (27%), Positives = 121/296 (40%), Gaps = 58/296 (19%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPD---STDT--------SSNT 74 +F +L S C D+VE+ D + + GR+C + +P+ STD+ SSN Sbjct: 363 NFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNW 422 Query: 75 ------AVVRVWWGS--QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL 126 AV G + G SPNYP+ ++ WRI EG + LTF + + Sbjct: 423 VGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 H SC +++ V +G +S + + C +IKS+ + + + F +DGS GF Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFA 541 Query: 187 ASHTSSED--------------------------------ADKVGCCKLCGGSLPNTPEG 214 + D DK C CGG L G Sbjct: 542 VNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NG 600 Query: 215 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 + TSPG+ + Y N NC W L P Q I + F+ F E + C++D +E R Sbjct: 601 SITSPGWP--KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVR 652 Score = 61.6 bits (148), Expect = 2e-09 Identities = 56/209 (26%), Positives = 88/209 (42%), Gaps = 21/209 (10%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 Q S G +SP YPN WRI+ G +I L F++L L C ++V V +G Sbjct: 327 QDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGF 386 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 +P + C S + I S+ + + V F + + GF A + + + Sbjct: 387 WRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-----------I 434 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + G+ SP Y +Y + C W + + + F+ F +E H C Sbjct: 435 CGGDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCA 489 Query: 264 FDVLEFRVVASEHWKVPFSLISRLSGWSE 292 +D LE R SE +LI R G+ + Sbjct: 490 YDYLEVRDGHSE----SSTLIGRYCGYEK 514 Score = 47.0 bits (110), Expect = 6e-05 Identities = 53/197 (26%), Positives = 78/197 (39%), Gaps = 22/197 (11%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFN---LQNSSGCEKDFVEIWDYHTSGNILG 57 ++L+F SD S N GF N F++ + N GCE+ + N LG Sbjct: 525 LWLKFVSDGSINKAGFA-------VNFFKEVDECSRPNRGGCEQRCL---------NTLG 568 Query: 58 RYCANTIPDSTDTSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 Y + P G G+ TSP +P P + W++ AP + Sbjct: 569 SYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYR 628 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 I+L F + C + V V +G+ ++S K C S I S N M+V F + Sbjct: 629 ISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-EKPEVITSQYNNMRVEFKS 687 Query: 177 DGSRPYGGFTASHTSSE 193 D + GF A H SE Sbjct: 688 DNTVSKKGFKA-HFFSE 703 >gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo sapiens] Length = 823 Score = 86.3 bits (212), Expect = 9e-17 Identities = 80/296 (27%), Positives = 121/296 (40%), Gaps = 58/296 (19%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPD---STDT--------SSNT 74 +F +L S C D+VE+ D + + GR+C + +P+ STD+ SSN Sbjct: 363 NFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNW 422 Query: 75 ------AVVRVWWGS--QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL 126 AV G + G SPNYP+ ++ WRI EG + LTF + + Sbjct: 423 VGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 H SC +++ V +G +S + + C +IKS+ + + + F +DGS GF Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFA 541 Query: 187 ASHTSSED--------------------------------ADKVGCCKLCGGSLPNTPEG 214 + D DK C CGG L G Sbjct: 542 VNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NG 600 Query: 215 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270 + TSPG+ + Y N NC W L P Q I + F+ F E + C++D +E R Sbjct: 601 SITSPGWP--KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVR 652 Score = 61.6 bits (148), Expect = 2e-09 Identities = 56/209 (26%), Positives = 88/209 (42%), Gaps = 21/209 (10%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 Q S G +SP YPN WRI+ G +I L F++L L C ++V V +G Sbjct: 327 QDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGF 386 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 +P + C S + I S+ + + V F + + GF A + + + Sbjct: 387 WRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-----------I 434 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG + G+ SP Y +Y + C W + + + F+ F +E H C Sbjct: 435 CGGDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCA 489 Query: 264 FDVLEFRVVASEHWKVPFSLISRLSGWSE 292 +D LE R SE +LI R G+ + Sbjct: 490 YDYLEVRDGHSE----SSTLIGRYCGYEK 514 Score = 46.6 bits (109), Expect = 7e-05 Identities = 50/191 (26%), Positives = 75/191 (39%), Gaps = 21/191 (10%) Query: 1 MYLRFRSDNSPNHMGFKGLSRHYLTNSFEDFN---LQNSSGCEKDFVEIWDYHTSGNILG 57 ++L+F SD S N GF N F++ + N GCE+ + N LG Sbjct: 525 LWLKFVSDGSINKAGFA-------VNFFKEVDECSRPNRGGCEQRCL---------NTLG 568 Query: 58 RYCANTIPDSTDTSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 Y + P G G+ TSP +P P + W++ AP + Sbjct: 569 SYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYR 628 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 I+L F + C + V V +G+ ++S K C S I S N M+V F + Sbjct: 629 ISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-EKPEVITSQYNNMRVEFKS 687 Query: 177 DGSRPYGGFTA 187 D + GF A Sbjct: 688 DNTVSKKGFKA 698 >gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] Length = 415 Score = 82.0 bits (201), Expect = 2e-15 Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 8/181 (4%) Query: 85 GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIR 144 G +G S +P + P W+IT PEG+ + L F + L C + V V+NG Sbjct: 39 GESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-H 97 Query: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204 +N ++ + C + + + SSGN M V +D + GF A +++E ++ + C Sbjct: 98 ANGQRIGRFCGTFRPGA-LVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD--QYC 154 Query: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQF 264 GG L + P G+F +P + R+Y + C W + P N I + FE F +E C++ Sbjct: 155 GGLL-DRPSGSFKTPNWPD-RDYPAGVTCVWHIVAPK--NQLIELKFEKFDVERDNYCRY 210 Query: 265 D 265 D Sbjct: 211 D 211 Score = 58.9 bits (141), Expect = 1e-08 Identities = 45/189 (23%), Positives = 83/189 (43%), Gaps = 31/189 (16%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVWWGSQGS 86 +F +L++ + C DFV++++ H +G +GR+C P + +S N +V++ + + Sbjct: 74 NFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTA 133 Query: 87 ----------------------------AGTSTSPNYPNLN-PHGRIYEWRITAPEGRQI 117 +G+ +PN+P+ + P G W I AP+ + I Sbjct: 134 GNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLI 193 Query: 118 TLTFSNLRLAMHLSCNSEHVIVFNGIRSN-SPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 L F + C ++V VFNG N + ++ K C + + I S N + + F + Sbjct: 194 ELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGD-SPPAPIVSERNELLIQFLS 252 Query: 177 DGSRPYGGF 185 D S GF Sbjct: 253 DLSLTADGF 261 >gi|72384339 CUB domain containing protein 2 [Homo sapiens] Length = 449 Score = 78.6 bits (192), Expect = 2e-14 Identities = 52/180 (28%), Positives = 81/180 (45%), Gaps = 17/180 (9%) Query: 87 AGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSN 146 +G +SPN+P L P+ W I EG + LTF L H +C+ + + ++NG + Sbjct: 38 SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPD 97 Query: 147 SPQ-LEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCG 205 L + C V SS + M VIF +D GF+A + +CG Sbjct: 98 KGNLLGRFCGKV-PPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKD----------VCG 146 Query: 206 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFD 265 G L G TSP Y NY ++ C W + G + + + F DF +E +++C +D Sbjct: 147 GVLTGL-SGVLTSPEYP--NNYPNSMECHWVIR--AAGPAHVKLVFVDFQVEGNEECTYD 201 Score = 72.4 bits (176), Expect = 1e-12 Identities = 72/276 (26%), Positives = 114/276 (41%), Gaps = 46/276 (16%) Query: 27 SFEDFNLQNSSGCEKDFVEIWDYHT--SGNILGRYCANTIPDSTDTSSNTAVVRVWWGSQ 84 +F F+L+ C DF+EI++ + GN+LGR+C +P TSS + ++ + Sbjct: 71 TFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGK-VPPPPFTSSWHVMSVIFHSDK 129 Query: 85 ---------------------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123 G +G TSP YPN P+ W I A + L F + Sbjct: 130 HVASHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD 189 Query: 124 LRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183 ++ + C ++V V G + C S + + S G+ ++V+F +D + Sbjct: 190 FQVEGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPT-LVSLGHELQVVFKSDFNIGGR 246 Query: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243 GF A + S E C+ + GNF+SP Y +Y N+ C WT+ P Sbjct: 247 GFKAYYFSGE-------CQ----EVYMAMRGNFSSPQYPS--SYPNNIRCHWTIRLP--P 291 Query: 244 NSSIYIHFEDFYLES----HQDCQFDVLEFRVVASE 275 + + F D LE + C FD L ASE Sbjct: 292 GYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASE 327 Score = 52.4 bits (124), Expect = 1e-06 Identities = 54/242 (22%), Positives = 96/242 (39%), Gaps = 43/242 (17%) Query: 8 DNSPN----HMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYH--TSGNILGRYCA 61 +N PN H + ++ F DF ++ + C D+V + T G+ YC Sbjct: 163 NNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGH---HYCG 219 Query: 62 NTIPDS-------------TDTSSNTAVVRVWWGS-------QGSAGTSTSPNYPNLNPH 101 +T P + +D + + ++ S G +SP YP+ P+ Sbjct: 220 STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPN 279 Query: 102 GRIYEWRITAPEGRQITLTFSNLRL----AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSV 157 W I P G Q+ + F +L L ++ +C+ +H+ F+G +P L C Sbjct: 280 NIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGH- 338 Query: 158 NVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFT 217 ++ + SS N + ++ TD S GF+ ++ + +GC GS EG Sbjct: 339 HLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQ----LGC-----GSGSTEGEGEAL 389 Query: 218 SP 219 P Sbjct: 390 QP 391 Score = 47.4 bits (111), Expect = 4e-05 Identities = 27/65 (41%), Positives = 33/65 (50%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P GNF+SP + R Y N C W + SS+ + F F LE H C Sbjct: 30 CGGVL-SAPSGNFSSPNFP--RLYPYNTECSWLIVVAE--GSSVLLTFHAFDLEYHDTCS 84 Query: 264 FDVLE 268 FD LE Sbjct: 85 FDFLE 89 >gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] Length = 449 Score = 72.8 bits (177), Expect = 1e-12 Identities = 58/194 (29%), Positives = 82/194 (42%), Gaps = 32/194 (16%) Query: 27 SFEDFNLQNSSGCEKDFVEIW-DYHTSGNILGRYCANTIPDSTDTSSNTAVVRV------ 79 SF F+L+ C D +E++ TSG LGR+C P N +R+ Sbjct: 78 SFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGT 137 Query: 80 -------WWGSQGSAGTS---------------TSPNYPNLN-PHGRIYEWRITAPEGRQ 116 W+ + ++GT T+PN+P + P G W I AP + Sbjct: 138 GGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQV 197 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNG-IRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFF 175 I LTF L C + V VFNG + +S +L K C V I S GN + V F Sbjct: 198 IALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDA-VPGSISSEGNELLVQFV 256 Query: 176 TDGSRPYGGFTASH 189 +D S GF+AS+ Sbjct: 257 SDLSVTADGFSASY 270 Score = 70.9 bits (172), Expect = 4e-12 Identities = 48/182 (26%), Positives = 85/182 (46%), Gaps = 7/182 (3%) Query: 84 QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143 +G +G S +PNL P + W IT PEG+ ++L+F L +H +C + + VF G Sbjct: 42 KGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGS 101 Query: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203 ++ +L + C + + + + GN + + TD GF ++ + + Sbjct: 102 GTSGQRLGRFCGTFR-PAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH--QF 158 Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L +G T+P + +Y ++C W + P + I + FE F LE C+ Sbjct: 159 CGGRLEKA-QGTLTTPNWP-ESDYPPGISCSWHIIAP--PDQVIALTFEKFDLEPDTYCR 214 Query: 264 FD 265 +D Sbjct: 215 YD 216 Score = 38.1 bits (87), Expect = 0.027 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 5/66 (7%) Query: 203 LCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262 LCGG + G S G+ + Y N C WT++ P ++ + F F LE H C Sbjct: 36 LCGGDVKGE-SGYVASEGFPNL--YPPNKECIWTITVPE--GQTVSLSFRVFDLELHPAC 90 Query: 263 QFDVLE 268 ++D LE Sbjct: 91 RYDALE 96 >gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens] Length = 607 Score = 72.0 bits (175), Expect = 2e-12 Identities = 51/167 (30%), Positives = 83/167 (49%), Gaps = 20/167 (11%) Query: 107 WRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSS 166 W I PE + I + FS ++L SC SE++ VF+G SN P L ++CS + +SS Sbjct: 60 WTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYVPVFESS 119 Query: 167 GNTMKVIFFTDGSR------PYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPG 220 +T+ TD +R + F + + S + CGG L +T EG+FTSP Sbjct: 120 SSTLTFQIVTDSARIQRTVFVFYYFFSPNISIPN---------CGGYL-DTLEGSFTSPN 169 Query: 221 YDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVL 267 Y + + C W + + + I ++F++ +LE + C+FD L Sbjct: 170 YP--KPHPELAYCVWHIQ--VEKDYKIKLNFKEIFLEIDKQCKFDFL 212 Score = 65.5 bits (158), Expect = 2e-10 Identities = 49/193 (25%), Positives = 85/193 (44%), Gaps = 31/193 (16%) Query: 28 FEDFNLQNSSGCEKDFVEIWDYHTS-GNILGRYCA-NTIPDSTDTSSNTAVVRVWWGS-- 83 F L CE + ++++D +S G +LG+ C+ N ++SS+T ++ S Sbjct: 74 FSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYVPVFESSSSTLTFQIVTDSAR 133 Query: 84 -------------------------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118 G+ TSPNYP +P W I + +I Sbjct: 134 IQRTVFVFYYFFSPNISIPNCGGYLDTLEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIK 193 Query: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178 L F + L + C + + +++G +NS + ++C V + E SS N++ V+ TD Sbjct: 194 LNFKEIFLEIDKQCKFDFLAIYDGPSTNSGLIGQVCGRVTPTFE--SSSNSLTVVLSTDY 251 Query: 179 SRPYGGFTASHTS 191 + Y GF+AS+TS Sbjct: 252 ANSYRGFSASYTS 264 Score = 30.0 bits (66), Expect = 7.2 Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 29/175 (16%) Query: 27 SFEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPDSTDTSSNTAVVRVWWGSQG 85 +F++ L+ C+ DF+ I+D T+ ++G+ C P +S++ VV + Sbjct: 195 NFKEIFLEIDKQCKFDFLAIYDGPSTNSGLIGQVCGRVTPTFESSSNSLTVVLSTDYANS 254 Query: 86 SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRS 145 G S S + IY I +LT S+ R+ + +S ++ FN Sbjct: 255 YRGFSAS--------YTSIYAENINT-----TSLTCSSDRMRVIIS--KSYLEAFNS-NG 298 Query: 146 NSPQLE------KLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGG---FTASHTS 191 N+ QL+ KL + V S + G KV D S Y F+AS TS Sbjct: 299 NNLQLKDPTCRPKLSNVVEFSVPLNGCGTIRKV---EDQSITYTNIITFSASSTS 350 >gi|239756223 PREDICTED: ankyrin repeat domain-containing protein ENSP00000383090-like [Homo sapiens] Length = 270 Score = 67.8 bits (164), Expect = 3e-11 Identities = 31/42 (73%), Positives = 35/42 (83%) Query: 522 LSQSHATEQPEGTSEGTPDEAAPLAERTPDMAESLVEKPPDE 563 +S++ PEGTSEGTPDEAAPL ERTPDMAESLVE+ PDE Sbjct: 229 ISKNSQNSNPEGTSEGTPDEAAPLVERTPDMAESLVERTPDE 270 >gi|169209369 PREDICTED: similar to Putative ankyrin repeat domain-containing protein ENSP00000383090 [Homo sapiens] Length = 193 Score = 67.8 bits (164), Expect = 3e-11 Identities = 31/42 (73%), Positives = 35/42 (83%) Query: 522 LSQSHATEQPEGTSEGTPDEAAPLAERTPDMAESLVEKPPDE 563 +S++ PEGTSEGTPDEAAPL ERTPDMAESLVE+ PDE Sbjct: 152 ISKNSQNSNPEGTSEGTPDEAAPLVERTPDMAESLVERTPDE 193 >gi|239745040 PREDICTED: ankyrin repeat domain-containing protein ENSP00000383090-like [Homo sapiens] Length = 270 Score = 67.8 bits (164), Expect = 3e-11 Identities = 31/42 (73%), Positives = 35/42 (83%) Query: 522 LSQSHATEQPEGTSEGTPDEAAPLAERTPDMAESLVEKPPDE 563 +S++ PEGTSEGTPDEAAPL ERTPDMAESLVE+ PDE Sbjct: 229 ISKNSQNSNPEGTSEGTPDEAAPLVERTPDMAESLVERTPDE 270 >gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 precursor [Homo sapiens] Length = 533 Score = 67.0 bits (162), Expect = 5e-11 Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 20/195 (10%) Query: 81 WGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN-LRLAMHLSCNSEHVIV 139 W G TSPNYP+ P R + I A + I L F + C +H+ V Sbjct: 44 WTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEV 103 Query: 140 FNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVG 199 +G SP + + C N IKSSG + + FF DG GF+A + + D D Sbjct: 104 RDGPFGFSPIIGRFCGQQN-PPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKD 162 Query: 200 CCKLCGGSLPNTPEGNFTSPGYDGV-----------RNYSRNLNCEWTLSNPNQGNSSIY 248 G+L P F G +G+ S ++C+W + P + S IY Sbjct: 163 L-----GALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPR--SKIY 215 Query: 249 IHFEDFYLESHQDCQ 263 + F D+ +++ +C+ Sbjct: 216 LRFLDYEMQNSNECK 230 Score = 35.8 bits (81), Expect = 0.13 Identities = 15/53 (28%), Positives = 30/53 (56%) Query: 28 FEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVW 80 F D+ +QNS+ C+++FV ++D +S L +T+ + + V+R+W Sbjct: 218 FLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMW 270 Score = 30.4 bits (67), Expect = 5.5 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 13/101 (12%) Query: 172 VIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNL 231 +I G+ G T T+SE V C G + G FTSP Y Y + Sbjct: 15 IILHLSGATKKG--TEKQTTSETQKSVQC----GTWTKHAEGGIFTSPNYPS--KYPPDR 66 Query: 232 NCEWTL-SNPNQGNSSIYIHFEDFY-LESHQDCQFDVLEFR 270 C + + + P Q I ++F++ Y +E +C+FD +E R Sbjct: 67 ECIYIIEAAPRQ---CIELYFDEKYSIEPSWECKFDHIEVR 104 >gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 precursor [Homo sapiens] Length = 532 Score = 67.0 bits (162), Expect = 5e-11 Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 20/195 (10%) Query: 81 WGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN-LRLAMHLSCNSEHVIV 139 W G TSPNYP+ P R + I A + I L F + C +H+ V Sbjct: 43 WTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEV 102 Query: 140 FNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVG 199 +G SP + + C N IKSSG + + FF DG GF+A + + D D Sbjct: 103 RDGPFGFSPIIGRFCGQQN-PPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKD 161 Query: 200 CCKLCGGSLPNTPEGNFTSPGYDGV-----------RNYSRNLNCEWTLSNPNQGNSSIY 248 G+L P F G +G+ S ++C+W + P + S IY Sbjct: 162 L-----GALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPR--SKIY 214 Query: 249 IHFEDFYLESHQDCQ 263 + F D+ +++ +C+ Sbjct: 215 LRFLDYEMQNSNECK 229 Score = 35.8 bits (81), Expect = 0.13 Identities = 15/53 (28%), Positives = 30/53 (56%) Query: 28 FEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVW 80 F D+ +QNS+ C+++FV ++D +S L +T+ + + V+R+W Sbjct: 217 FLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMW 269 Score = 30.4 bits (67), Expect = 5.5 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 13/101 (12%) Query: 172 VIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNL 231 +I G+ G T T+SE V C G + G FTSP Y Y + Sbjct: 14 IILHLSGATKKG--TEKQTTSETQKSVQC----GTWTKHAEGGIFTSPNYPS--KYPPDR 65 Query: 232 NCEWTL-SNPNQGNSSIYIHFEDFY-LESHQDCQFDVLEFR 270 C + + + P Q I ++F++ Y +E +C+FD +E R Sbjct: 66 ECIYIIEAAPRQ---CIELYFDEKYSIEPSWECKFDHIEVR 103 >gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] Length = 1662 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 12/155 (7%) Query: 47 WDYHTSGNI--LGRYCANTIPDSTDTS----SNTAVVRVWWGSQG----SAGTSTSPNYP 96 W H G+ G C+ T +ST T + T R G ++GT +SP+YP Sbjct: 973 WLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYP 1032 Query: 97 NLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS 156 P+ W I G +I L FSNL+L H +C+ ++V +F+G ++S L K+C+ Sbjct: 1033 AYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICN- 1091 Query: 157 VNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTS 191 + SS N M + F +D S GF A + S Sbjct: 1092 -DTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1125 Score = 53.1 bits (126), Expect = 8e-07 Identities = 46/154 (29%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 57 GRYCANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 G + + P T NT + SQ S G +SP YP P+ W I + Sbjct: 1236 GNHLSTPAPFLNITRPNTDYSCGGFLSQPS-GDFSSPFYPGNYPNNAKCVWDIEVQNNYR 1294 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 +T+ F +++L CN +++ VF+G +SP + ++C S SS N M + F + Sbjct: 1295 VTVIFRDVQLEG--GCNYDYIEVFDGPYRSSPLIARVCDGARGS--FTSSSNFMSIRFIS 1350 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPN 210 D S GF A + SS D LC LPN Sbjct: 1351 DHSITRRGFRAEYYSSPSNDSTNL--LC---LPN 1379 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P G+F+SP Y G NY N C W + Q N + + F D LE C Sbjct: 1257 CGGFL-SQPSGDFSSPFYPG--NYPNNAKCVWDIE--VQNNYRVTVIFRDVQLEG--GCN 1309 Query: 264 FDVLE 268 +D +E Sbjct: 1310 YDYIE 1314 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L G F+SP Y Y N C W + N G I + F + LE+H +C Sbjct: 1015 CGGFLFYA-SGTFSSPSYPAY--YPNNAKCVWEIE-VNSGYR-INLGFSNLKLEAHHNCS 1069 Query: 264 FDVLE 268 FD +E Sbjct: 1070 FDYVE 1074 >gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] Length = 1788 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 12/155 (7%) Query: 47 WDYHTSGNI--LGRYCANTIPDSTDTS----SNTAVVRVWWGSQG----SAGTSTSPNYP 96 W H G+ G C+ T +ST T + T R G ++GT +SP+YP Sbjct: 1099 WLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYP 1158 Query: 97 NLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS 156 P+ W I G +I L FSNL+L H +C+ ++V +F+G ++S L K+C+ Sbjct: 1159 AYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICN- 1217 Query: 157 VNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTS 191 + SS N M + F +D S GF A + S Sbjct: 1218 -DTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1251 Score = 53.1 bits (126), Expect = 8e-07 Identities = 46/154 (29%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 57 GRYCANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 G + + P T NT + SQ S G +SP YP P+ W I + Sbjct: 1362 GNHLSTPAPFLNITRPNTDYSCGGFLSQPS-GDFSSPFYPGNYPNNAKCVWDIEVQNNYR 1420 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 +T+ F +++L CN +++ VF+G +SP + ++C S SS N M + F + Sbjct: 1421 VTVIFRDVQLEG--GCNYDYIEVFDGPYRSSPLIARVCDGARGS--FTSSSNFMSIRFIS 1476 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPN 210 D S GF A + SS D LC LPN Sbjct: 1477 DHSITRRGFRAEYYSSPSNDSTNL--LC---LPN 1505 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P G+F+SP Y G NY N C W + Q N + + F D LE C Sbjct: 1383 CGGFL-SQPSGDFSSPFYPG--NYPNNAKCVWDIE--VQNNYRVTVIFRDVQLEG--GCN 1435 Query: 264 FDVLE 268 +D +E Sbjct: 1436 YDYIE 1440 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L G F+SP Y Y N C W + N G I + F + LE+H +C Sbjct: 1141 CGGFLFYA-SGTFSSPSYPAY--YPNNAKCVWEIE-VNSGYR-INLGFSNLKLEAHHNCS 1195 Query: 264 FDVLE 268 FD +E Sbjct: 1196 FDYVE 1200 >gi|148539844 deleted in malignant brain tumors 1 isoform c precursor [Homo sapiens] Length = 2403 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 12/155 (7%) Query: 47 WDYHTSGNI--LGRYCANTIPDSTDTS----SNTAVVRVWWGSQG----SAGTSTSPNYP 96 W H G+ G C+ T +ST T + T R G ++GT +SP+YP Sbjct: 1714 WLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYP 1773 Query: 97 NLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS 156 P+ W I G +I L FSNL+L H +C+ ++V +F+G ++S L K+C+ Sbjct: 1774 AYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICN- 1832 Query: 157 VNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTS 191 + SS N M + F +D S GF A + S Sbjct: 1833 -DTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1866 Score = 53.1 bits (126), Expect = 8e-07 Identities = 46/154 (29%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 57 GRYCANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 G + + P T NT + SQ S G +SP YP P+ W I + Sbjct: 1977 GNHLSTPAPFLNITRPNTDYSCGGFLSQPS-GDFSSPFYPGNYPNNAKCVWDIEVQNNYR 2035 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 +T+ F +++L CN +++ VF+G +SP + ++C S SS N M + F + Sbjct: 2036 VTVIFRDVQLEG--GCNYDYIEVFDGPYRSSPLIARVCDGARGS--FTSSSNFMSIRFIS 2091 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPN 210 D S GF A + SS D LC LPN Sbjct: 2092 DHSITRRGFRAEYYSSPSNDSTNL--LC---LPN 2120 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P G+F+SP Y G NY N C W + Q N + + F D LE C Sbjct: 1998 CGGFL-SQPSGDFSSPFYPG--NYPNNAKCVWDIE--VQNNYRVTVIFRDVQLEG--GCN 2050 Query: 264 FDVLE 268 +D +E Sbjct: 2051 YDYIE 2055 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L G F+SP Y Y N C W + N G I + F + LE+H +C Sbjct: 1756 CGGFLFYA-SGTFSSPSYPAY--YPNNAKCVWEIE-VNSGYR-INLGFSNLKLEAHHNCS 1810 Query: 264 FDVLE 268 FD +E Sbjct: 1811 FDYVE 1815 >gi|148539842 deleted in malignant brain tumors 1 isoform b precursor [Homo sapiens] Length = 2413 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 12/155 (7%) Query: 47 WDYHTSGNI--LGRYCANTIPDSTDTS----SNTAVVRVWWGSQG----SAGTSTSPNYP 96 W H G+ G C+ T +ST T + T R G ++GT +SP+YP Sbjct: 1724 WLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYP 1783 Query: 97 NLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS 156 P+ W I G +I L FSNL+L H +C+ ++V +F+G ++S L K+C+ Sbjct: 1784 AYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICN- 1842 Query: 157 VNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTS 191 + SS N M + F +D S GF A + S Sbjct: 1843 -DTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1876 Score = 53.1 bits (126), Expect = 8e-07 Identities = 46/154 (29%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 57 GRYCANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 G + + P T NT + SQ S G +SP YP P+ W I + Sbjct: 1987 GNHLSTPAPFLNITRPNTDYSCGGFLSQPS-GDFSSPFYPGNYPNNAKCVWDIEVQNNYR 2045 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 +T+ F +++L CN +++ VF+G +SP + ++C S SS N M + F + Sbjct: 2046 VTVIFRDVQLEG--GCNYDYIEVFDGPYRSSPLIARVCDGARGS--FTSSSNFMSIRFIS 2101 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPN 210 D S GF A + SS D LC LPN Sbjct: 2102 DHSITRRGFRAEYYSSPSNDSTNL--LC---LPN 2130 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P G+F+SP Y G NY N C W + Q N + + F D LE C Sbjct: 2008 CGGFL-SQPSGDFSSPFYPG--NYPNNAKCVWDIE--VQNNYRVTVIFRDVQLEG--GCN 2060 Query: 264 FDVLE 268 +D +E Sbjct: 2061 YDYIE 2065 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L G F+SP Y Y N C W + N G I + F + LE+H +C Sbjct: 1766 CGGFLFYA-SGTFSSPSYPAY--YPNNAKCVWEIE-VNSGYR-INLGFSNLKLEAHHNCS 1820 Query: 264 FDVLE 268 FD +E Sbjct: 1821 FDYVE 1825 >gi|148539840 deleted in malignant brain tumors 1 isoform a precursor [Homo sapiens] Length = 1785 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 12/155 (7%) Query: 47 WDYHTSGNI--LGRYCANTIPDSTDTS----SNTAVVRVWWGSQG----SAGTSTSPNYP 96 W H G+ G C+ T +ST T + T R G ++GT +SP+YP Sbjct: 1096 WLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYP 1155 Query: 97 NLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS 156 P+ W I G +I L FSNL+L H +C+ ++V +F+G ++S L K+C+ Sbjct: 1156 AYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICN- 1214 Query: 157 VNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTS 191 + SS N M + F +D S GF A + S Sbjct: 1215 -DTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1248 Score = 53.1 bits (126), Expect = 8e-07 Identities = 46/154 (29%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 57 GRYCANTIPDSTDTSSNTAVVRVWWGSQGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQ 116 G + + P T NT + SQ S G +SP YP P+ W I + Sbjct: 1359 GNHLSTPAPFLNITRPNTDYSCGGFLSQPS-GDFSSPFYPGNYPNNAKCVWDIEVQNNYR 1417 Query: 117 ITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176 +T+ F +++L CN +++ VF+G +SP + ++C S SS N M + F + Sbjct: 1418 VTVIFRDVQLEG--GCNYDYIEVFDGPYRSSPLIARVCDGARGS--FTSSSNFMSIRFIS 1473 Query: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPN 210 D S GF A + SS D LC LPN Sbjct: 1474 DHSITRRGFRAEYYSSPSNDSTNL--LC---LPN 1502 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + P G+F+SP Y G NY N C W + Q N + + F D LE C Sbjct: 1380 CGGFL-SQPSGDFSSPFYPG--NYPNNAKCVWDIE--VQNNYRVTVIFRDVQLEG--GCN 1432 Query: 264 FDVLE 268 +D +E Sbjct: 1433 YDYIE 1437 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L G F+SP Y Y N C W + N G I + F + LE+H +C Sbjct: 1138 CGGFLFYA-SGTFSSPSYPAY--YPNNAKCVWEIE-VNSGYR-INLGFSNLKLEAHHNCS 1192 Query: 264 FDVLE 268 FD +E Sbjct: 1193 FDYVE 1197 >gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] Length = 909 Score = 60.8 bits (146), Expect = 4e-09 Identities = 58/195 (29%), Positives = 87/195 (44%), Gaps = 30/195 (15%) Query: 87 AGTSTSPNYPNLNPHGRIYEWRITAPEGRQ-ITLTFS-NLRLAMHLSCNSEHVIVFNGIR 144 AG TSP YP P + EW + APE Q I L F+ + + H C + + + +G Sbjct: 37 AGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYDFIEIRDGDS 95 Query: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASH----TSSEDADKVGC 200 ++ L K C ++ I SSG+ + + F +D +R GF+ + T SED K Sbjct: 96 ESADLLGKHCGNI-APPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNF- 153 Query: 201 CKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT-LSNPNQGNSSIYIHFEDFYLE-- 257 +P G SPG+ Y NL+C +T L+ P I + F F LE Sbjct: 154 ---------TSPNGTIESPGFP--EKYPHNLDCTFTILAKPKM---EIILQFLIFDLEHD 199 Query: 258 ----SHQDCQFDVLE 268 DC++D L+ Sbjct: 200 PLQVGEGDCKYDWLD 214 Score = 49.3 bits (116), Expect = 1e-05 Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 3/72 (4%) Query: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263 CGG L + G TSPGY ++Y + NCEW + P + N I ++F + DC+ Sbjct: 28 CGGRLNSKDAGYITSPGYP--QDYPSHQNCEWIVYAP-EPNQKIVLNFNPHFEIEKHDCK 84 Query: 264 FDVLEFRVVASE 275 +D +E R SE Sbjct: 85 YDFIEIRDGDSE 96 Score = 48.5 bits (114), Expect = 2e-05 Identities = 44/183 (24%), Positives = 75/183 (40%), Gaps = 33/183 (18%) Query: 39 CEKDFVEIWDYHT-SGNILGRYCANTIPDSTDTSSNTAVVRVW--WGSQGSA-------- 87 C+ DF+EI D + S ++LG++C N P + +S + ++ + QG+ Sbjct: 83 CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIF 142 Query: 88 ---------------GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRL------ 126 GT SP +P PH + I A +I L F L Sbjct: 143 KTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQ 202 Query: 127 AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFT 186 C + + +++GI P + K C + SE++SS + + F TD + GF+ Sbjct: 203 VGEGDCKYDWLDIWDGIPHVGPLIGKYCGT-KTPSELRSSTGILSLTFHTDMAVAKDGFS 261 Query: 187 ASH 189 A + Sbjct: 262 ARY 264 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.130 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,027,088 Number of Sequences: 37866 Number of extensions: 1367546 Number of successful extensions: 4933 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 70 Number of HSP's successfully gapped in prelim test: 68 Number of HSP's that attempted gapping in prelim test: 4265 Number of HSP's gapped (non-prelim): 500 length of query: 671 length of database: 18,247,518 effective HSP length: 109 effective length of query: 562 effective length of database: 14,120,124 effective search space: 7935509688 effective search space used: 7935509688 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.