Guide to the Human Genome
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Search of human proteins with 239746149

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
         (816 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...  1654   0.0  
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...  1629   0.0  
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...  1031   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   212   1e-54
gi|116284392 mucin 2 precursor [Homo sapiens]                         162   1e-39
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  148   2e-35
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  148   2e-35
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  148   2e-35
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   148   2e-35
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   145   1e-34
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]             142   1e-33
gi|47132519 Ras association and pleckstrin homology domains 1 is...   142   1e-33
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...   140   5e-33
gi|112421108 capicua homolog [Homo sapiens]                           139   1e-32
gi|110832843 TBP-associated factor 4 [Homo sapiens]                   138   2e-32
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   138   2e-32
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]        137   3e-32
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]        135   2e-31
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        134   3e-31
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         134   3e-31
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         134   3e-31
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         134   3e-31
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      132   1e-30
gi|239508790 PREDICTED: hypothetical protein, partial [Homo sapi...   128   2e-29
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...   126   7e-29
gi|55750053 atrophin-1 [Homo sapiens]                                 125   1e-28
gi|55750041 atrophin-1 [Homo sapiens]                                 125   1e-28
gi|150170670 piccolo isoform 2 [Homo sapiens]                         124   3e-28
gi|150378539 piccolo isoform 1 [Homo sapiens]                         124   3e-28
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]     124   4e-28

>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 1654 bits (4284), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 120
           RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL
Sbjct: 61  RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 120

Query: 121 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 180
           GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL
Sbjct: 121 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 180

Query: 181 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240
           PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL
Sbjct: 181 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240

Query: 241 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 300
           SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP
Sbjct: 241 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 300

Query: 301 SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA 360
           SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA
Sbjct: 301 SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA 360

Query: 361 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420
           LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP
Sbjct: 361 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420

Query: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 480
           VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA
Sbjct: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 480

Query: 481 PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 540
           PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA
Sbjct: 481 PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 540

Query: 541 SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 600
           SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP
Sbjct: 541 SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 600

Query: 601 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGS 660
           EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGS
Sbjct: 601 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGS 660

Query: 661 ADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLG 720
           ADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLG
Sbjct: 661 ADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLG 720

Query: 721 ALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLS 780
           ALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLS
Sbjct: 721 ALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLS 780

Query: 781 PLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH 816
           PLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH
Sbjct: 781 PLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH 816


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 1629 bits (4219), Expect = 0.0
 Identities = 815/855 (95%), Positives = 816/855 (95%), Gaps = 39/855 (4%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRT---------SRPPASGRGERAPPAKNTSPGPVSSPGRA 111
           RAGGIGGATIPESAPRAGPTR+         SRPPASGRGERAPPAKNTSPGPVSSPGRA
Sbjct: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120

Query: 112 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 171
           SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS
Sbjct: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180

Query: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
           RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
           SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS
Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 292 SSPLATPSPSA------------------------------PPSPSAPPSLQTLPSPPAT 321
           SSPLATPSPSA                              PPSPSAPPSLQTLPSPPAT
Sbjct: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360

Query: 322 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381
           PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL
Sbjct: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420

Query: 382 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441
           ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ
Sbjct: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480

Query: 442 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 501
           VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG
Sbjct: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 540

Query: 502 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 561
           QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG
Sbjct: 541 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600

Query: 562 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 621
           PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD
Sbjct: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 660

Query: 622 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681
           AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG
Sbjct: 661 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 720

Query: 682 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 741
           ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE
Sbjct: 721 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 780

Query: 742 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 801
           GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA
Sbjct: 781 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 840

Query: 802 SPQGDWTVVEVETFH 816
           SPQGDWTVVEVETFH
Sbjct: 841 SPQGDWTVVEVETFH 855


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 1031 bits (2667), Expect = 0.0
 Identities = 583/894 (65%), Positives = 618/894 (69%), Gaps = 107/894 (11%)

Query: 8    AKAGAAAR-TPAARAPGLLTPRPPGSPRP-------PPPVTPAALRVLGAAGAVGRKPLA 59
            A++G +AR TP A       P  P  P+P       PP VTP       A G +   PLA
Sbjct: 253  ARSGPSARGTPRA-------PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 305

Query: 60   ---------------ERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGP 104
                           + A     AT+P S P A P   + P  S     APP+  T P P
Sbjct: 306  TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPS-----APPSLQTLPSP 360

Query: 105  VSSP---GRASGTTRP---GPLGQKGLRISAEETVARGKATEAPKRSALSA-GARRDTSG 157
             ++P      S TT P    P  Q    I    ++        P   ALS+  A      
Sbjct: 361  PATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGS 420

Query: 158  PTPGTPSPAMARRSRAAGTEVGLP-RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR 216
            PT       +    R     +  P RPA +    PP + P    +S    ++  P+ +  
Sbjct: 421  PTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPL 480

Query: 217  RRPSAGGGLQRPASRSLSSSATPLSS--------PARSGPSARGTPRAPAHPSQPKPKGL 268
              P     LQ  +S +  S   PLSS         +   P +  TP  PA  + P  + L
Sbjct: 481  SSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP--PASLTTPPLENL 538

Query: 269  QALRPPQVTPPRKDAAPALGP-LSSSPLATPSP-SAPPSPSAPPSLQTLPSPPATPPSQA 326
             +L PP   P +  +AP   P L + P   P P  APPSP   P  +T PS  ATPP QA
Sbjct: 539  PSLAPP---PLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPET-PSSIATPPPQA 594

Query: 327  TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP 386
              +L SP LQ     LPSPPLSPLATPPPQAPP LALPPLQAPPSPPASPPLSPLATPSP
Sbjct: 595  PPALASPPLQG----LPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSP 650

Query: 387  QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 446
            QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP
Sbjct: 651  QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 710

Query: 447  PASPPMSPSATPPPQAPPPLAAPPLQ---------------------------------- 472
            PASPPMSPSATPPPQAPPPLAAPPLQ                                  
Sbjct: 711  PASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPP 770

Query: 473  ----------LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 522
                      LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ
Sbjct: 771  SPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830

Query: 523  APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 582
            APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS
Sbjct: 831  APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 890

Query: 583  TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 642
            TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF
Sbjct: 891  TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 950

Query: 643  RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 702
            RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA
Sbjct: 951  RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 1010

Query: 703  GASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 762
            GASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG
Sbjct: 1011 GASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 1070

Query: 763  ARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH 816
            ARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH
Sbjct: 1071 ARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTVVEVETFH 1124



 Score =  849 bits (2193), Expect = 0.0
 Identities = 537/968 (55%), Positives = 563/968 (58%), Gaps = 220/968 (22%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRT---------SRPPASGRGERAPPAKNTSPGPVSSPGRA 111
           RAGGIGGATIPESAPRAGPTR+         SRPPASGRGERAPPAKNTSPGPVSSPGRA
Sbjct: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120

Query: 112 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 171
           SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS
Sbjct: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180

Query: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
           RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
           SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS
Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 292 SSPLATPSPS---------------------------------APPSPSAPPSLQTLPSP 318
           SSPLATPSPS                                 APPSPSAPPSLQTLPSP
Sbjct: 301 SSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP 360

Query: 319 PATPPS----------------------------------------------QATTSLGS 332
           PATPPS                                              QATTSLGS
Sbjct: 361 PATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGS 420

Query: 333 PTLQATHSFL-------------PSPPLS-PLATPPPQAPPAL-ALPPLQAPPSPPASPP 377
           PTLQATHSFL             PS P S P  +PP QAP +L A PPLQ   SP  SP 
Sbjct: 421 PTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPL 480

Query: 378 LSPLATPSPQAPNALAVHLLQAPFS-------------PPPS------------------ 406
            SPL     QA ++LA H  QAP S              PPS                  
Sbjct: 481 SSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPS 540

Query: 407 ---PPVQAPFSP---------------PASPPVSPSATPPSQAPPSLAAPPLQVPP---S 445
              PP+Q   +P               P   P SP  TPP + P S+A PP Q PP   S
Sbjct: 541 LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS 600

Query: 446 PP----ASPPMSPSATPPPQAPPPLAAPPLQ-------------LAKPPPQAPPALATPP 488
           PP     SPP+SP ATPPPQAPP LA PPLQ             LA P PQAP ALA   
Sbjct: 601 PPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 660

Query: 489 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 548
           LQA  SPP S P QAPFSP AS P+SP ATPP QAPP LAAP LQVPPSPPASP +    
Sbjct: 661 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 720

Query: 549 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST--------LSGPDLAGHSSSATSTP 600
            PP   P    + P   L + P PP  P  SPS+T        L+ P L    S   S P
Sbjct: 721 TPPPQAPPPLAAPP---LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP 777

Query: 601 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG----APGAPLPWPP-A 655
                          A PPP A  A   P   +  P+PP +F G    +P A LP  P A
Sbjct: 778 M-----------SPLAKPPPQAPPALATPPLQAL-PSPPASFPGQAPFSPSASLPMSPLA 825

Query: 656 TGPGSADGLCTIYETEGPESATPAPGAL------DPGPSPGTSGGKAAAGAGAG---ASS 706
           T P  A  +      + P S   +P          PGP    SG +       G     S
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 885

Query: 707 RSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAA 766
           RSP     G          +  H  S T   +  E   G   G  GGA          AA
Sbjct: 886 RSPSSTLSG--------PDLAGHSSSAT---STPEELRGYDSGPEGGAAASPPPDAELAA 934

Query: 767 LSDAELGR 774
              A   R
Sbjct: 935 CHPAAWSR 942


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  212 bits (539), Expect = 1e-54
 Identities = 216/681 (31%), Positives = 283/681 (41%), Gaps = 117/681 (17%)

Query: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES-APRAGPTRTSRP 85
            P P   P  P P    AL +  ++    R   A +        IP S +P+  PT  +  
Sbjct: 894  PFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKG-------IPASPSPKGAPTPPAAT 946

Query: 86   PASGRGERAPPAKNTSPGP--VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPK 143
            P S +G  A P+   +P P   + P    G   P P G      +   +   G AT +PK
Sbjct: 947  PPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPK 1006

Query: 144  RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 203
                          PTP   +P   + S AA      P P  ++ P   T    K   +A
Sbjct: 1007 ------------GAPTPPAVTPPSPKGSPAA-----TPFPKGASTPPAATPPSPKGSPAA 1049

Query: 204  SEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP 263
            +      P+  A   PS  GG   PA+ SL  + TP   PA + PS +G P  P+    P
Sbjct: 1050 TPLPKGAPTTPAATLPSPKGG---PATPSLKGAPTP---PAATPPSPKGGPATPSPKGAP 1103

Query: 264  KPKGLQALRPPQ-----VTPPRKDA--APALGPLS-SSPLATPSP-SAPPSPSAPPSLQT 314
             P    A  PP       TPP K A   PA  P S    LATP P  AP +P+A P    
Sbjct: 1104 MP---PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATP---- 1156

Query: 315  LPSPP---ATPPSQA--TTSLGSPTLQATHSFLPSP---PLSPLATPPPQAPPALALPPL 366
             PSP    ATPP +   TT   +P         PSP   P +P AT PP     LA P  
Sbjct: 1157 -PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT-PPSPKGGLATPSP 1214

Query: 367  QAPPSPPASPPLSP---LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 423
            +  P+ PA+ P SP   LATPSP+           AP +P  +PP  +P   PA+PP   
Sbjct: 1215 KGAPTTPAATPPSPKGGLATPSPKG----------APTTPAATPP--SPKGGPATPPPKG 1262

Query: 424  SATPPSQAPPS----LAAPPLQVPPSP----PASPPMSPSATPPPQAP-PPLAAPPLQLA 474
            + TPP+  PPS    LA PP +  P+P    P SP   P+ +PP  AP PP A PP    
Sbjct: 1263 APTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKG 1322

Query: 475  K---PPPQ---APPALATPPLQALPSPPASFPGQ--APFSPSASL-PMSPLATPPPQAPP 525
                PPP+    PPA+  P  +  P+ PA+ P     P +PS+   P  P ATP  +  P
Sbjct: 1323 SPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382

Query: 526  VLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
             +       PPSP   P + +P+  PT       S   + L+    P  P +R  ++T S
Sbjct: 1383 AM------TPPSPKRGPAIPSPKGDPT-------SPAVIPLSPKKAPATPVTREGAATPS 1429

Query: 586  GPDLAGHSSSATSTPEELR--GYDSGPEGG-AAASPPPDAELAACHPAAWSRGPAPPLAF 642
              DL    +    TP  L+     S P+GG A  S   D  L A  P +    PAP    
Sbjct: 1430 KGDL----TPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVA 1485

Query: 643  -----RGAPGAPLPWPPATGP 658
                 + AP  P P    T P
Sbjct: 1486 TSSSPKKAPATPAPMGAPTLP 1506



 Score =  196 bits (499), Expect = 6e-50
 Identities = 218/786 (27%), Positives = 291/786 (37%), Gaps = 130/786 (16%)

Query: 14   ARTPAARAPGLLTPRPPGSPRPP---PP--------------VTPAALRVLGAAGAVGRK 56
            A TP +   G  TP P G+P PP   PP               TP A+      G+    
Sbjct: 967  AATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAAT 1026

Query: 57   PLAERAGGIGGATIPE--------SAPRAGPTRTSRPPASGRGERAPPAKNTSPGP--VS 106
            P  + A     AT P           P+  PT  +    S +G  A P+   +P P   +
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT 1086

Query: 107  SPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPA 166
             P    G   P P G      +   +   G AT   K +  +  A   +      TP P 
Sbjct: 1087 PPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPK 1146

Query: 167  MARRSRAA---GTEVGLPRPAPSARPRPPTEGPRKSVSS-ASEHSTTEPSPAARRRPSAG 222
             A  + AA     + GL  P P   P  P   P       A+      P+  A   PS  
Sbjct: 1147 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK 1206

Query: 223  GGLQRPASRSLSSSATPLSSP-----ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ-- 275
            GGL  P+ +   +  TP ++P       + PS +G P  PA  + P PKG  A  PP+  
Sbjct: 1207 GGLATPSPK--GAPTTPAATPPSPKGGLATPSPKGAPTTPA-ATPPSPKGGPATPPPKGA 1263

Query: 276  ---------------VTPPRKDA---------APALGPLSSSPLATPSPSA--PPSPSAP 309
                            TPP K A         +P  GP +S P   P+P A  PPSP   
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323

Query: 310  PSL---QTLPSPPA-TPPSQATTSLGSPTLQATHSFL---PSPPLSPLATPPPQAPPALA 362
            P     +  P+PPA TPPS      G+PTL AT       P+ P S     PP A P+  
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPK----GTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHK 1379

Query: 363  LPPLQAPPSP------------PASP---PLSPLATPSPQAPNALAVHLLQAPFSPPPSP 407
              P   PPSP            P SP   PLSP   P+       A    +   +PP   
Sbjct: 1380 GGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVT 1439

Query: 408  PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP--PPQAPPP 465
            PV    +P  S P    ATP S+  P+L A     P  PPA   ++ S++P   P  P P
Sbjct: 1440 PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP 1499

Query: 466  LAAPPLQLAKP--PPQAPPALATPPLQALP-SPPASFPGQAPFSPSASLPMSPLATPPPQ 522
            + AP L    P  P + P   ATP  +  P +P A+   +   +P+   P   L  P   
Sbjct: 1500 MGAPTLPAVIPSSPKEVP---ATPSSRRDPIAPTATLLSKK--TPATLAPKEALIPPAMT 1554

Query: 523  APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL------APGP---P 573
             P     P +  P   PA+P+ +    PP   P T    P     L      +P P   P
Sbjct: 1555 VPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAP 1614

Query: 574  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS 633
             PP+ +P S   GP       + TS P         P   A+ +     ++ A  P A  
Sbjct: 1615 TPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVT----CKMGATVPQASK 1670

Query: 634  RGPAP--PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE----SATPAPGALDPGP 687
              PA   P A +    AP P         +  + T    +GP+    SAT  P   DP  
Sbjct: 1671 GLPAKKGPTALKEVLVAPAP--------ESTPIITAPTRKGPQTKKSSATSPPICPDPSA 1722

Query: 688  SPGTSG 693
              G+ G
Sbjct: 1723 KNGSKG 1728



 Score =  194 bits (494), Expect = 2e-49
 Identities = 189/674 (28%), Positives = 255/674 (37%), Gaps = 65/674 (9%)

Query: 13   AARTPAARAP----GLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK--PLAERAGGIG 66
            A  TPAA  P    GL TP P G+P  P    P+    L      G    P A      G
Sbjct: 1171 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1230

Query: 67   GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSS--PGRASGTTRPGPLGQKG 124
            G   P  +P+  PT  +  P S +G  A P    +P P ++  P    G   P   G   
Sbjct: 1231 GLATP--SPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN 1288

Query: 125  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 184
              +    +   G AT  PK +     A   +   +PGTP P      + A T   +  P+
Sbjct: 1289 PAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPP------KGAPTPPAVTPPS 1342

Query: 185  PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR----SLSSSATPL 240
            P   P  P   P       +  S   P+P A      GG    P S     ++ S     
Sbjct: 1343 PKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP 1402

Query: 241  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS- 299
            +SPA    S +  P  P             L PP VTP     APA       P ATPS 
Sbjct: 1403 TSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGP-ATPSS 1461

Query: 300  ----------PSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349
                      P +P  P AP  + T  SP   P + A   +G+PTL A    +PS P   
Sbjct: 1462 KGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP--MGAPTLPAV---IPSSPKEV 1516

Query: 350  LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 409
             ATP  +  P      L +  +P    P   L  P+   P+      +  P   P +P  
Sbjct: 1517 PATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSS 1576

Query: 410  QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 469
            +   SPPA   V+PS    + +P  L  PP    PSP  + P  P+ TPP     P    
Sbjct: 1577 KEASSPPA---VTPSTYKGAPSPKELLIPPAVTSPSPKEA-PTPPAVTPPSPEKGPATPA 1632

Query: 470  PLQLAKPPPQAPPAL---ATPPLQALPSPPASFPGQAPFSPSASLPMS---PLATPPPQA 523
            P      PP  P +L    T P        A+ P  +   P+   P +    L  P P++
Sbjct: 1633 PKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPES 1692

Query: 524  PPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
             P++ AP  + P +  +S T  +P   P P       GP  T  +AP P  P  +  S T
Sbjct: 1693 TPIITAPTRKGPQTKKSSAT--SPPICPDPSAKNGSKGPLST--VAPAPLLPVQKDSSKT 1748

Query: 584  LSGPDLAGHSSSATSTPEELRGYDSGPEGGAA---ASPPPDAELAACHPAAWSRGPAPPL 640
              G D A HS      P E +   S P   AA     P P++       A+ S  P+PP+
Sbjct: 1749 AKGKD-ASHSPKGPLAPPESKA--STPLTAAAFEKVLPKPES-------ASVSAAPSPPV 1798

Query: 641  AFRGAPGAPLPWPP 654
            +   AP +P+P  P
Sbjct: 1799 SLPLAP-SPVPTLP 1811



 Score =  179 bits (455), Expect = 7e-45
 Identities = 216/719 (30%), Positives = 272/719 (37%), Gaps = 111/719 (15%)

Query: 72   ESAPRAGPT--RTSRPPASGRGERAPPAKNT--SPGPVSSPGRASGTTRPGPLGQKGLRI 127
            ++AP+  P+   TS  P       A  AK +   P P+  P  AS  T P  +      I
Sbjct: 564  QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKP--ASSMTSPLGVNSSASVI 621

Query: 128  SAEETVARGKATEAPKRSALSAGARR------DTSGPTPGTPSPAMARRSRAAGTEVGLP 181
              +       A    K S ++           D +G  P T        + A+    G  
Sbjct: 622  KTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTV 681

Query: 182  RPAPSARP-RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240
              AP   P +  T      V +ASE+    PSP     P A           + +   P 
Sbjct: 682  SLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLA---------TLVLAPEIPK 732

Query: 241  SSPARSGPSARGTPRAPAHPSQPKPKGLQ---ALRPPQVTP---PRKDAAPALGPLSSSP 294
            S P+ S P A GTP     P   K  G+    AL P   +P   P +D+  +    S   
Sbjct: 733  SVPSPSLPPA-GTP-----PGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGT 786

Query: 295  LA----TPSP---SAPPSPSAPPSLQTLPSP---------PATP------PSQATTSLGS 332
            L     +PSP   S  P    PP+ +    P         P +P      P  + +  GS
Sbjct: 787  LTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGS 846

Query: 333  PTLQAT-HSFLPSPPLSPLATPPPQA-----PPALALPPLQAP-PSPPASP-PLSPLATP 384
                AT HS  P+PP SP   P P A     P  + LPP + P PS    P P    ATP
Sbjct: 847  KDSPATTHS--PTPP-SPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATP 903

Query: 385  SPQAPNALAV--------HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436
            +P+   AL++            AP   P SP  +   +PPA+ P SP   P + +P    
Sbjct: 904  APKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP 963

Query: 437  APPLQVPPSPPASPPMSPSATPPPQ-AP-PPLAAPPLQLAKPPPQAPPALATPPLQALPS 494
             PP   PPSP   P     ATP P+ AP PP A PP     P   +P    TPP    PS
Sbjct: 964  TPPAATPPSPKGGP-----ATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPS 1018

Query: 495  PPASFPGQAPFSPSASLPM---------SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 545
            P  S P   PF   AS P          SP ATP P+  P   A  L  P   PA+P+L+
Sbjct: 1019 PKGS-PAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLK 1077

Query: 546  APRRPPTPGPDTSVSGPRLTLAL-APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 604
                PP   P +   GP       AP PP     SP   L+ P   G  ++  +TP    
Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATP---- 1133

Query: 605  GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL 664
                 P+GG A  PP  A      PAA    P   LA     GAP   P AT P    GL
Sbjct: 1134 ---PSPKGGLATPPPKGAPTT---PAATPPSPKGGLATPPPKGAPTT-PAATPPSPKGGL 1186

Query: 665  CTIYETEGPESATPAPGALDPGPSPG--TSGGKAAAGAGAGASSRSPKQARLGELPLGA 721
                 T  P+ A   P A  P P  G  T   K A    A A+  SPK       P GA
Sbjct: 1187 A----TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPA-ATPPSPKGGLATPSPKGA 1240



 Score =  142 bits (357), Expect = 2e-33
 Identities = 188/674 (27%), Positives = 256/674 (37%), Gaps = 136/674 (20%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
            K     A  TP +   G  T  P G+P PP    P+        G+ G  P     G   
Sbjct: 1284 KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPS------PKGSPGTPP---PKGAPT 1334

Query: 67   GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 126
               +   +P+  PT  +  P+S  G   P +K     P ++P    G     P  ++G  
Sbjct: 1335 PPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPA 1394

Query: 127  ISAEETVARGKAT--EAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR-P 183
            I + +      A    +PK++  +   R   + P+ G  +P        A T V L + P
Sbjct: 1395 IPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP-------PAVTPVSLKKAP 1447

Query: 184  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
            A SA    P  GP      A+  S  +P+  A   PS     + PA + +++S++P  +P
Sbjct: 1448 ATSA----PKGGP------ATPSSKGDPTLPAVTPPSP---KEPPAPKQVATSSSPKKAP 1494

Query: 244  ARSGPSARGTPRAPA-HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS- 301
            A   P+  G P  PA  PS PK        P   +  R   AP    LS    AT +P  
Sbjct: 1495 AT--PAPMGAPTLPAVIPSSPKEV------PATPSSRRDPIAPTATLLSKKTPATLAPKE 1546

Query: 302  -------APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP---LSPLA 351
                     PSP   P++ T    PATP S+  +S  + T  +T+   PSP    + P  
Sbjct: 1547 ALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVT-PSTYKGAPSPKELLIPPAV 1605

Query: 352  TPPPQAPPALALPPLQAPPSP---PASP-----PLSPLATPS------------------ 385
            T P  +P     PP   PPSP   PA+P     P SP  TPS                  
Sbjct: 1606 TSP--SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGA 1663

Query: 386  --PQAPNALAV--------HLLQAPFSPPPSPPVQAPF--------SPPASPPV--SPSA 425
              PQA   L           +L AP +P  +P + AP         S   SPP+   PSA
Sbjct: 1664 TVPQASKGLPAKKGPTALKEVLVAP-APESTPIITAPTRKGPQTKKSSATSPPICPDPSA 1722

Query: 426  TPPSQAPPSLAAP----PLQVPPSPPAS------PPMSPSATPPPQAPPPLAAPPLQLAK 475
               S+ P S  AP    P+Q   S  A        P  P A P  +A  PL A   +   
Sbjct: 1723 KNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVL 1782

Query: 476  PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAP--LLQ 533
            P P+      +  + A PSPP S P          L  SP+ T PP+   + ++P  +L+
Sbjct: 1783 PKPE------SASVSAAPSPPVSLP----------LAPSPVPTLPPKQQFLPSSPGLVLE 1826

Query: 534  VPPSP--PASPTLQAPRRPPTP----GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 587
             P  P  PA      P  PP P     P  SV     T   A  P P PS     T +  
Sbjct: 1827 SPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNK 1886

Query: 588  DLAGHSSSATSTPE 601
                 S S  S PE
Sbjct: 1887 GSGTESDSDESVPE 1900



 Score =  105 bits (263), Expect = 1e-22
 Identities = 194/800 (24%), Positives = 281/800 (35%), Gaps = 139/800 (17%)

Query: 10  AGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT 69
           A +  +T   + P  + P P G+P PP  V+      +         P+A    G+  A+
Sbjct: 180 APSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCV--------TPMASIQSGV--AS 229

Query: 70  IPESAPR-----AGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124
           +P++ P      A P       +S       P   +  GPVS P   S +T+  P+    
Sbjct: 230 LPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSS 289

Query: 125 LRISAEET-----VARGKATEAPKRSALSAGARRDTSGPT----PGTPSPAMARRSRAAG 175
            + +   T     ++ G       +S+  +      +GP+    P   + ++   S  A 
Sbjct: 290 QKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGAS 349

Query: 176 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 235
                    PS R   P    R  V  A+  +    +P+  + PS    +    S SL +
Sbjct: 350 --------YPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSL-N 400

Query: 236 SATPLSSPARSGPSARGTPRAPAHPS--QPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            AT  S    +    + +P A  H       P       P  VT P   AA        +
Sbjct: 401 VATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVA 460

Query: 294 PLATPSPSAPP----SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP---- 345
              +P  S+ P     P++P +L   P  P  P +Q  T+L  P        LP P    
Sbjct: 461 TCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPP----LPDPEDLK 516

Query: 346 --PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 403
             P S L   P Q         LQ  P+     P SP         +   + L+QA  +P
Sbjct: 517 NLPSSVLVKFPTQ-------KDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQA--AP 567

Query: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP-PLQVPPSPPASP---PMSPSATPP 459
             SP  Q+  S P   P+SP AT    A  SL  P P+  P S   SP     S S    
Sbjct: 568 KNSPSFQSTSSSP-EIPLSPEAT---LAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623

Query: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519
                P +A PL           +L TP + A P   A   G AP +   +   +  A+P
Sbjct: 624 DSYAGPDSAGPL--------LKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASP 675

Query: 520 --------PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 571
                    P+  PV    L  +P  P AS        P  P P  + + P  TL LAP 
Sbjct: 676 FLEGTVSLAPKNHPVKEGTLTTLPLVPTASENC-----PVAPSPQNTCA-PLATLVLAPE 729

Query: 572 PP---PPPSRSPSSTLSGP---DLAGHSSS---ATSTPEELRGYDSGPEGGAAAS----- 617
            P   P PS  P+ T  G    D   H+S+     S+P+E    DSG    A++      
Sbjct: 730 IPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTY 789

Query: 618 ------------------PP-------PDAEL----AACHPAAWSRGPAPPLAFRGAPGA 648
                             PP       PD  +    +   P   S  P   L+F+G+  +
Sbjct: 790 LADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDS 849

Query: 649 PL----PWPPATGPGSADGLCTIYETEG---PESATPAPGALD-PGPSPGTSGGKAAAGA 700
           P     P PP+          T    +G   P   TP P  ++ P P  G +        
Sbjct: 850 PATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAP 909

Query: 701 GAGASSRSPKQARLGELPLG 720
               +S SPK+AR    P G
Sbjct: 910 ALSMTSSSPKKARATPAPKG 929



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 159/638 (24%), Positives = 231/638 (36%), Gaps = 131/638 (20%)

Query: 142 PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVS 201
           P  SALS  A     GPT   P     ++   +      P P+PS     P E P    S
Sbjct: 27  PMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSS 86

Query: 202 SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 261
           S     T  P   A   P+    L  P    +S +A  L+SP    P+ +GTP + A   
Sbjct: 87  S----GTALPLGTAPEAPTFLPNLIGP---PISPAALALASP-MIAPTLKGTPSSSA--- 135

Query: 262 QPKPKGLQALRPPQVT-----PPRKDAAPALGPL--SSSPLATPSPSAPPSP-------- 306
              P  L AL P  V      PP    +P    +  S S +   +P AP  P        
Sbjct: 136 ---PLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVP 192

Query: 307 -SAPPSLQTLPSPP---ATPPSQATTSLGSPTLQATHSFLP-SPPLSPLATPPPQ----- 356
               P+ +  PSPP   +T P    T + S  +Q+  + LP + P + LA   PQ     
Sbjct: 193 SEVVPNPKGTPSPPCIVSTVPYHCVTPMAS--IQSGVASLPQTTPTTTLAIASPQVKDTT 250

Query: 357 ------APPALALPPLQAPPSPPASPPLS----PLATPS---------PQAPNALAVHLL 397
                 +P       L+ P SPPA+  LS    P+ T S         P  P +L  HL 
Sbjct: 251 ISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLA 310

Query: 398 ---QAPF--------------SPPPSPPVQAPFSPP-ASPPVSPSATPP-----SQAPPS 434
              Q+ F              S P    +    S   AS P   S  PP        P +
Sbjct: 311 PLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPAT 370

Query: 435 LAAPPLQVP-----PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP---PALAT 486
           +AA P+  P     PS  +S   SPS +        L+     + K  P A    P +A 
Sbjct: 371 VAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQ 430

Query: 487 PPLQALPSPP--ASFPGQAPFSPSASLPMSPLATPPPQAPPV-----------LAAPLLQ 533
            P+ ++ + P   + P     +P+ +  ++   +PP  + P+           + AP+  
Sbjct: 431 MPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAP 490

Query: 534 VPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP-------------GPPPPPSRSP 580
             PS   + TL+ P  PP P P+   + P   L   P             G P  P+++ 
Sbjct: 491 KEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550

Query: 581 SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPL 640
            +T   P +     +A       +   S PE        P+A L     A  S G   P+
Sbjct: 551 LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPE----IPLSPEATL-----AKKSLGEPLPI 601

Query: 641 AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATP 678
              G P + +  P   G  S+  +       GP+SA P
Sbjct: 602 ---GKPASSMTSP--LGVNSSASVIKTDSYAGPDSAGP 634



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 103/370 (27%), Positives = 145/370 (39%), Gaps = 47/370 (12%)

Query: 307 SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 366
           + P + Q LP P A       +S  S T        P P L P  +P PQ  P  A    
Sbjct: 8   TVPATEQELPQPQAETAVLPMSSALSVTAALGQ---PGPTLPPPCSPAPQQCPLSAAN-- 62

Query: 367 QAPPSP-PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPPASPPVSPS 424
           QA P P P++   +PL  P PQ+ +  A+ L  AP +P   P  +  P SP A    SP 
Sbjct: 63  QASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPM 122

Query: 425 ATPPSQAPPSLAAPPLQV---PPSPPASPPMSPS-ATPPPQAPPPLAAPPLQLAKP-PPQ 479
             P  +  PS +AP   V   P S   S    P+  T PP      +   + L+ P  P 
Sbjct: 123 IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPS 182

Query: 480 AP-------PALATPPLQALPSPPASFPGQAPF---SPSASL-----------PMSPLAT 518
            P       P+   P  +  PSPP       P+   +P AS+           P + LA 
Sbjct: 183 EPKTNLNKVPSEVVPNPKGTPSPPC-IVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAI 241

Query: 519 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 578
             PQ      + +L + P  P S +L+ P  PP     ++ S P +T +     P  P  
Sbjct: 242 ASPQVKDTTISSVL-ISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD 300

Query: 579 SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPA- 637
            P S   G  LA    S+  + + L     G  G +A S P    ++  H +  +  P+ 
Sbjct: 301 FPISL--GSHLAPLHQSSFGSVQLL-----GQTGPSALSDPTVKTISVDHSSTGASYPSQ 353

Query: 638 ----PPLAFR 643
               PPL  R
Sbjct: 354 RSVIPPLPSR 363


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  162 bits (410), Expect = 1e-39
 Identities = 133/436 (30%), Positives = 170/436 (38%), Gaps = 65/436 (14%)

Query: 155  TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA 214
            T  P   TPSP     +    T    P    +  P PPT  P   +++     TT P P 
Sbjct: 1398 TPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTP-PPTTTPSPPITT-----TTTPPPT 1451

Query: 215  ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP 274
                P        P S + +   T   SP  + PS   T  +P   +   P       PP
Sbjct: 1452 TTPSP--------PISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTP-------PP 1496

Query: 275  QVTPPRKDAAPALGPLSSS---PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLG 331
              TP      P   P S++   P  TPSP    + + PP+  T PSPP T P    TS  
Sbjct: 1497 TTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPT--TTPSPPTTTPITPPTS-- 1552

Query: 332  SPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNA 391
            + TL  T +  PSPP +   TPPP   P+   PP    PSPP     +P  T +P  P  
Sbjct: 1553 TTTLPPTTT--PSPPPTTTTTPPPTTTPS---PPTTTTPSPPTITTTTPPPTTTPSPPTT 1607

Query: 392  LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA--- 448
                    P +  PSPP   P +PP S    P  T PS  P +   PP    PSPP    
Sbjct: 1608 TTT---TPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1664

Query: 449  -SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 507
             SPP++ + TPPP   P   + P+     PP     + TP     PS P +         
Sbjct: 1665 PSPPITTTTTPPPTTTP---SSPITTTPSPPTT--TMTTPSPTTTPSSPIT--------- 1710

Query: 508  SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLA 567
            + + P S     PP  P  +  P     PSPP +          T  P T+ S P  T  
Sbjct: 1711 TTTTPSSTTTPSPP--PTTMTTPSPTTTPSPPTTTM--------TTLPPTTTSSPLTTTP 1760

Query: 568  LAPGPPPPPSRSPSST 583
            L P    PP+ SP ST
Sbjct: 1761 LPPS-ITPPTFSPFST 1775



 Score =  157 bits (398), Expect = 3e-38
 Identities = 128/439 (29%), Positives = 168/439 (38%), Gaps = 58/439 (13%)

Query: 139  TEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP------RPAPSARPRPP 192
            T  P  +  S      T+ P   TPSP +   +    T    P       P P+  P PP
Sbjct: 1414 TTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPP 1473

Query: 193  TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 252
            T  P    ++ S  +TT  +P     PS               + TP++ PA        
Sbjct: 1474 TTTPSPPTTTPSPPTTTTTTPPPTTTPS-------------PPTTTPITPPA-------S 1513

Query: 253  TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL-ATPSPSAPPSPSAPPS 311
            T   P   +   P       PP  TP      P   P S++ L  T +PS PP+ +  P 
Sbjct: 1514 TTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPP 1573

Query: 312  LQTLPSPP-ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP 370
              T PSPP  T PS  T +  +P    T    PSPP +   TPPP   P+   PP   P 
Sbjct: 1574 PTTTPSPPTTTTPSPPTITTTTPPPTTT----PSPPTTTTTTPPPTTTPS---PPTTTPI 1626

Query: 371  SPPAS-PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS 429
            +PP S   L P  TPSP               +PPP+     P +   SPP++ + TPP 
Sbjct: 1627 TPPTSTTTLPPTTTPSPPPTTTT---------TPPPTTTPSPPTTTTPSPPITTTTTPPP 1677

Query: 430  QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPL 489
               PS    P+   PSPP +   +PS T  P +P      P     P P  P  + TP  
Sbjct: 1678 TTTPS---SPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSP-PPTTMTTPSP 1733

Query: 490  QALPSPP----ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 545
               PSPP     + P     SP  + P+ P  TPP  +P     P    P  P  + T  
Sbjct: 1734 TTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTP--TTPCVPLCNWTGW 1791

Query: 546  APRRPPT---PGPDTSVSG 561
                 P    PG DT + G
Sbjct: 1792 LDSGKPNFHKPGGDTELIG 1810



 Score =  157 bits (397), Expect = 4e-38
 Identities = 145/512 (28%), Positives = 191/512 (37%), Gaps = 73/512 (14%)

Query: 228  PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 287
            P  + +++ + P ++P  S P    T   P   + P P       PP  T P   + P  
Sbjct: 1391 PMDKCITTPSPPTTTP--SPPPTSTTTLPPT--TTPSPPTTTTTTPPPTTTP---SPPIT 1443

Query: 288  GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH---SFLPS 344
               +  P  TPSP    + + PP+  T PSPP T PS  TT+   PT   T    +  PS
Sbjct: 1444 TTTTPPPTTTPSPPISTTTTPPPT--TTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPS 1501

Query: 345  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 404
            PP +   TPP        LPP   P SPP +   +P                   P +  
Sbjct: 1502 PPTTTPITPPASTT---TLPPTTTP-SPPTTTTTTP-------------------PPTTT 1538

Query: 405  PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA----SPPMSPSATPPP 460
            PSPP   P +PP S    P  T PS  P +   PP    PSPP     SPP   + TPPP
Sbjct: 1539 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPP 1598

Query: 461  QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP 520
               P   +PP      PP  P    +PP     +PP S     P + + S P +   TPP
Sbjct: 1599 TTTP---SPPTTTTTTPP--PTTTPSPPTTTPITPPTSTTTLPP-TTTPSPPPTTTTTPP 1652

Query: 521  PQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 580
            P   P   +P     PSPP + T   P       P T+   P  T    P P   PS SP
Sbjct: 1653 PTTTP---SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPS-SP 1708

Query: 581  SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPL 640
             +T + P       S+T+TP       + P      SPP                   P 
Sbjct: 1709 ITTTTTP-------SSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL------------PP 1749

Query: 641  AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP----SPGTSGGKA 696
                +P    P PP+  P +     T   T          G LD G      PG      
Sbjct: 1750 TTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGDTELI 1809

Query: 697  AAGAGAG-ASSRSPKQARLGELPLGALQASVV 727
                G G A++ S +     ++P+G L  +VV
Sbjct: 1810 GDVCGPGWAANISCRATMYPDVPIGQLGQTVV 1841



 Score =  137 bits (345), Expect = 4e-32
 Identities = 115/446 (25%), Positives = 163/446 (36%), Gaps = 66/446 (14%)

Query: 24   LLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTS 83
            + TP PP +   PPP +                            T+P +   + PT T+
Sbjct: 1396 ITTPSPPTTTPSPPPTSTT--------------------------TLPPTTTPSPPTTTT 1429

Query: 84   RPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPK 143
              P        P    T+P P ++P     TT   P            T +    T +P 
Sbjct: 1430 TTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPP---------PTTTPSPPTTTPSPP 1480

Query: 144  RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 203
             +  S      T+ P   TPSP          +   LP   P+  P PPT          
Sbjct: 1481 TTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLP---PTTTPSPPTT--------- 1528

Query: 204  SEHSTTEPSPAARRRPSAGGGLQRPAS-RSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 262
               +TT P P     P     +  P S  +L  + TP   P  +      T  +P   + 
Sbjct: 1529 ---TTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1585

Query: 263  PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP--SPPA 320
            P P  +    PP  T P   + P     +  P  TPSP      + P S  TLP  + P+
Sbjct: 1586 PSPPTITTTTPPPTTTP---SPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPS 1642

Query: 321  TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP 380
             PP+  TT   + T     +  PSPP++   TPPP   P+    P+   PSPP +   +P
Sbjct: 1643 PPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPS---SPITTTPSPPTTTMTTP 1699

Query: 381  LATPSPQAPNALAVHLLQAPFS-PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP 439
              T +P +P    +     P S   PSPP     +P  +   SP  T  +  PP+  + P
Sbjct: 1700 SPTTTPSSP----ITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSP 1755

Query: 440  LQVPPSPPA--SPPMSPSATPPPQAP 463
            L   P PP+   P  SP +T  P  P
Sbjct: 1756 LTTTPLPPSITPPTFSPFSTTTPTTP 1781



 Score =  104 bits (259), Expect = 4e-22
 Identities = 143/717 (19%), Positives = 232/717 (32%), Gaps = 76/717 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3635 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3694

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3695 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3754

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3755 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3808

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3809 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3865

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3866 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3920

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3921 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3978

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3979 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 4037

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 4038 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 4097

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 4098 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4157

Query: 529  APLLQVPPSPPAS------PTLQAPRRPPTPGPDTSVSGPRLTLALAP------GPPPPP 576
               +   P+P  +      P        PTP P  + +GP    + AP        PPP 
Sbjct: 4158 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPE 4217

Query: 577  SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 636
            S +P ++ S       S++  ST          P     ++ PP    A    +      
Sbjct: 4218 SSTPQTSRSTSSPLTESTTLLST--------LPPAIEMTSTAPPSTPTAPTTTSGGHTLS 4269

Query: 637  APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSG 693
             PP      PG P      TG  SA    T+ +T    + TP P  L       T+G
Sbjct: 4270 PPPSTTTSPPGTPTR-GTTTGSSSAPTPSTV-QTTTTSAWTPTPTPLSTPSIIRTTG 4324



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 99/391 (25%), Positives = 139/391 (35%), Gaps = 53/391 (13%)

Query: 16   TPAARAPGLLTPRPP--GSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES 73
            T     P   TP PP   +  PPP  TP+              P++         T P +
Sbjct: 1427 TTTTTPPPTTTPSPPITTTTTPPPTTTPSP-------------PISTTT------TPPPT 1467

Query: 74   APRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133
               + PT T  PP +      P    T+P P ++P   + T    P     L  +   + 
Sbjct: 1468 TTPSPPTTTPSPPTTTPSP--PTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSP 1525

Query: 134  ARGKATEAPKRSALSAGARRDTSGPT-----PGTPSPAMARRSRAAGTEVGLPRPAPSAR 188
                 T  P  +  S       + PT     P T +P+    +         P P  +  
Sbjct: 1526 PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1585

Query: 189  PRPPT----EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS-LSSSATPLSSP 243
            P PPT      P  +  S    +TT P P     P     +  P S + L  + TP   P
Sbjct: 1586 PSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1645

Query: 244  ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS---PLATPSP 300
              +      T  +P   + P P       PP  T P         P +++   P  T +P
Sbjct: 1646 TTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTP 1705

Query: 301  SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA 360
            S+P + +  PS  T PSPP   P+  TT   SPT        PSPP + + T     PP 
Sbjct: 1706 SSPITTTTTPSSTTTPSPP---PTTMTTP--SPTT------TPSPPTTTMTT----LPPT 1750

Query: 361  LALPPLQAPPSPPA--SPPLSPLATPSPQAP 389
                PL   P PP+   P  SP +T +P  P
Sbjct: 1751 TTSSPLTTTPLPPSITPPTFSPFSTTTPTTP 1781



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 144/759 (18%), Positives = 236/759 (31%), Gaps = 89/759 (11%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3497 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3556

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3557 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3616

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3617 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3670

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3671 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3727

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3728 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3782

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3783 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3840

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3841 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3899

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3900 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3959

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3960 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4019

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 4020 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4079

Query: 579  SPSST----------------LSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDA 622
            +P++T                   P     +++ T TP         P G    +  P  
Sbjct: 4080 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPIT 4133

Query: 623  ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGA 682
                  P     G   P          +  P  T  G+     T   T    + TP P  
Sbjct: 4134 TTTTVTPTPTPTGTQTPTTTPITTTTTVT-PTPTPTGTQTPTTTPITTTTTVTPTPTPTG 4192

Query: 683  LDPGPSPGTSGGKAA--AGAGAGASSRSPKQARLGELPL 719
               GP   TS    A    +     S +P+ +R    PL
Sbjct: 4193 TQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL 4231



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 1910 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1969

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 1970 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2029

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2030 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2083

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2084 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2140

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2141 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2195

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2196 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2253

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2254 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2312

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2313 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2372

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2373 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2432

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2433 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2492

Query: 579  SPSST 583
            +P++T
Sbjct: 2493 TPTTT 2497



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 1933 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1992

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 1993 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2052

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2053 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2106

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2107 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2163

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2164 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2218

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2219 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2276

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2277 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2335

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2336 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2395

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2396 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2455

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2456 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2515

Query: 579  SPSST 583
            +P++T
Sbjct: 2516 TPTTT 2520



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 1956 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2015

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2016 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2075

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2076 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2129

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2130 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2186

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2187 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2241

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2242 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2299

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2300 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2358

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2359 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2418

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2419 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2478

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2479 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2538

Query: 579  SPSST 583
            +P++T
Sbjct: 2539 TPTTT 2543



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 1979 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2038

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2039 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2098

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2099 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2152

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2153 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2209

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2210 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2264

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2265 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2322

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2323 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2381

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2382 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2441

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2442 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2501

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2502 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2561

Query: 579  SPSST 583
            +P++T
Sbjct: 2562 TPTTT 2566



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2002 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2061

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2062 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2121

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2122 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2175

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2176 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2232

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2233 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2287

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2288 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2345

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2346 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2404

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2405 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2464

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2465 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2524

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2525 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2584

Query: 579  SPSST 583
            +P++T
Sbjct: 2585 TPTTT 2589



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2025 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2084

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2085 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2144

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2145 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2198

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2199 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2255

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2256 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2310

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2311 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2368

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2369 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2427

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2428 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2487

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2488 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2547

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2548 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2607

Query: 579  SPSST 583
            +P++T
Sbjct: 2608 TPTTT 2612



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2048 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2107

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2108 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2167

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2168 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2221

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2222 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2278

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2279 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2333

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2334 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2391

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2392 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2450

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2451 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2510

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2511 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2570

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2571 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2630

Query: 579  SPSST 583
            +P++T
Sbjct: 2631 TPTTT 2635



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2071 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2130

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2131 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2190

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2191 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2244

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2245 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2301

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2302 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2356

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2357 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2414

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2415 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2473

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2474 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2533

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2534 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2593

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2594 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2653

Query: 579  SPSST 583
            +P++T
Sbjct: 2654 TPTTT 2658



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2094 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2153

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2154 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2213

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2214 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2267

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2268 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2324

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2325 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2379

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2380 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2437

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2438 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2496

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2497 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2556

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2557 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2616

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2617 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2676

Query: 579  SPSST 583
            +P++T
Sbjct: 2677 TPTTT 2681



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2117 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2176

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2177 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2236

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2237 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2290

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2291 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2347

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2348 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2402

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2403 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2460

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2461 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2519

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2520 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2579

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2580 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2639

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2640 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2699

Query: 579  SPSST 583
            +P++T
Sbjct: 2700 TPTTT 2704



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2140 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2199

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2200 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2259

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2260 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2313

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2314 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2370

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2371 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2425

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2426 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2483

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2484 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2542

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2543 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2602

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2662

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2663 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2722

Query: 579  SPSST 583
            +P++T
Sbjct: 2723 TPTTT 2727



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2163 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2222

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2223 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2282

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2283 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2336

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2337 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2393

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2394 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2448

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2449 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2506

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2507 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2565

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2566 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2625

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2626 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2685

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2686 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2745

Query: 579  SPSST 583
            +P++T
Sbjct: 2746 TPTTT 2750



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2186 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2245

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2246 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2305

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2306 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2359

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2360 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2416

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2417 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2471

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2472 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2529

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2530 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2588

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2589 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2648

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2649 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2708

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2709 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2768

Query: 579  SPSST 583
            +P++T
Sbjct: 2769 TPTTT 2773



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2209 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2268

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2269 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2328

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2329 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2382

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2383 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2439

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2440 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2494

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2495 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2552

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2553 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2611

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2612 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2671

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2672 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2731

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2732 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2791

Query: 579  SPSST 583
            +P++T
Sbjct: 2792 TPTTT 2796



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2232 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2291

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2292 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2351

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2352 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2405

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2406 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2462

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2463 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2517

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2518 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2575

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2576 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2634

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2635 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2694

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2695 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2754

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2755 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2814

Query: 579  SPSST 583
            +P++T
Sbjct: 2815 TPTTT 2819



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2255 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2314

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2315 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2374

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2375 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2428

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2429 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2485

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2486 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2540

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2541 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2598

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2599 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2657

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2658 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2717

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2718 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2777

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2778 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2837

Query: 579  SPSST 583
            +P++T
Sbjct: 2838 TPTTT 2842



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2278 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2337

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2338 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2397

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2398 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2451

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2452 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2508

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2509 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2563

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2564 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2621

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2622 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2680

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2681 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2740

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2741 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2800

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2801 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2860

Query: 579  SPSST 583
            +P++T
Sbjct: 2861 TPTTT 2865



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2301 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2360

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2361 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2420

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2421 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2474

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2475 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2531

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2532 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2586

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2587 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2644

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2645 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2703

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2704 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2763

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2764 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2823

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2824 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2883

Query: 579  SPSST 583
            +P++T
Sbjct: 2884 TPTTT 2888



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2324 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2383

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2384 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2443

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2444 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2497

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2498 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2554

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2555 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2609

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2610 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2667

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2668 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2726

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2727 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2786

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2787 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2846

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2847 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2906

Query: 579  SPSST 583
            +P++T
Sbjct: 2907 TPTTT 2911



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2347 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2406

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2407 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2466

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2467 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2520

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2521 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2577

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2578 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2632

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2633 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2690

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2691 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2749

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2750 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2809

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2810 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2869

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2870 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2929

Query: 579  SPSST 583
            +P++T
Sbjct: 2930 TPTTT 2934



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2370 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2429

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2430 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2489

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2490 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2543

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2544 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2600

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2601 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2655

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2656 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2713

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2714 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2772

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2773 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2832

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2833 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2892

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2893 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2952

Query: 579  SPSST 583
            +P++T
Sbjct: 2953 TPTTT 2957



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2393 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2452

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2453 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2512

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2513 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2566

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2567 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2623

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2624 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2678

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2679 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2736

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2737 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2795

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2796 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2855

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2856 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2915

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2916 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2975

Query: 579  SPSST 583
            +P++T
Sbjct: 2976 TPTTT 2980



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2416 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2475

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2476 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2535

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2536 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2589

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2590 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2646

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2647 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2701

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2702 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2759

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2760 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2818

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2819 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2878

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2879 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2938

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2939 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2998

Query: 579  SPSST 583
            +P++T
Sbjct: 2999 TPTTT 3003



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2439 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2498

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2499 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2558

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2559 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2612

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2613 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2669

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2670 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2724

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2725 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2782

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2783 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2841

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2842 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2901

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2902 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2961

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2962 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3021

Query: 579  SPSST 583
            +P++T
Sbjct: 3022 TPTTT 3026



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2462 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2521

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2522 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2581

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2582 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2635

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2636 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2692

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2693 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2747

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2748 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2805

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2806 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2864

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2865 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2924

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2925 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2984

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 2985 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3044

Query: 579  SPSST 583
            +P++T
Sbjct: 3045 TPTTT 3049



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2485 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2544

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2545 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2604

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2605 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2658

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2659 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2715

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2716 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2770

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2771 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2828

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2829 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2887

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2888 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2947

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2948 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3007

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3008 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3067

Query: 579  SPSST 583
            +P++T
Sbjct: 3068 TPTTT 3072



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2508 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2567

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2568 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2627

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2628 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2681

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2682 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2738

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2739 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2793

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2794 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2851

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2852 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2910

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2911 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2970

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2971 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3030

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3031 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3090

Query: 579  SPSST 583
            +P++T
Sbjct: 3091 TPTTT 3095



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2531 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2590

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2591 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2650

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2651 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2704

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2705 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2761

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2762 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2816

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2817 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2874

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2875 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2933

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2934 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2993

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 2994 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3053

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3054 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3113

Query: 579  SPSST 583
            +P++T
Sbjct: 3114 TPTTT 3118



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2554 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2613

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2614 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2673

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2674 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2727

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2728 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2784

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2785 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2839

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2840 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2897

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2898 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2956

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2957 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3016

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3017 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3076

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3077 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3136

Query: 579  SPSST 583
            +P++T
Sbjct: 3137 TPTTT 3141



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2577 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2636

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2637 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2696

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2697 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2750

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2751 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2807

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2808 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2862

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2863 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2920

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2921 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 2979

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 2980 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3039

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3040 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3099

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3100 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3159

Query: 579  SPSST 583
            +P++T
Sbjct: 3160 TPTTT 3164



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2600 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2659

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2660 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2719

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2720 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2773

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2774 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2830

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2831 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2885

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2886 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2943

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2944 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3002

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3003 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3062

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3122

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3123 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3182

Query: 579  SPSST 583
            +P++T
Sbjct: 3183 TPTTT 3187



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2623 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2682

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2683 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2742

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2743 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2796

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2797 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2853

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2854 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2908

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2909 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2966

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2967 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3025

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3026 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3085

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3086 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3145

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3146 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3205

Query: 579  SPSST 583
            +P++T
Sbjct: 3206 TPTTT 3210



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2646 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2705

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2706 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2765

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2766 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2819

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2820 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2876

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2877 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2931

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2932 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 2989

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 2990 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3048

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3049 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3108

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3109 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3168

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3169 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3228

Query: 579  SPSST 583
            +P++T
Sbjct: 3229 TPTTT 3233



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2669 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2728

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2729 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2788

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2789 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2842

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2843 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2899

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2900 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2954

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2955 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3012

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3013 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3071

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3072 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3131

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3132 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3191

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3192 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3251

Query: 579  SPSST 583
            +P++T
Sbjct: 3252 TPTTT 3256



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2692 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2751

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2752 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2811

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2812 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2865

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2866 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2922

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2923 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 2977

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 2978 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3035

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3036 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3094

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3095 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3154

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3155 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3214

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3215 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3274

Query: 579  SPSST 583
            +P++T
Sbjct: 3275 TPTTT 3279



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2715 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2774

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2775 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2834

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2835 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2888

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2889 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2945

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2946 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3000

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3001 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3058

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3059 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3117

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3118 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3177

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3178 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3237

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3238 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3297

Query: 579  SPSST 583
            +P++T
Sbjct: 3298 TPTTT 3302



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2738 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2797

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2798 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2857

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2858 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2911

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2912 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2968

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2969 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3023

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3024 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3081

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3082 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3140

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3141 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3200

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3201 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3260

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3261 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3320

Query: 579  SPSST 583
            +P++T
Sbjct: 3321 TPTTT 3325



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2761 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2820

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2821 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2880

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2881 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2934

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2935 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2991

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 2992 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3046

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3047 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3104

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3105 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3163

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3164 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3223

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3224 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3283

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3284 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3343

Query: 579  SPSST 583
            +P++T
Sbjct: 3344 TPTTT 3348



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2784 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2843

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2844 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2903

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2904 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2957

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2958 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3014

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3015 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3069

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3070 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3127

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3128 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3186

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3187 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3246

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3247 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3306

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3307 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3366

Query: 579  SPSST 583
            +P++T
Sbjct: 3367 TPTTT 3371



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2807 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2866

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2867 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2926

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2927 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2980

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 2981 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3037

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3038 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3092

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3093 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3150

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3151 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3209

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3210 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3269

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3270 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3329

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3330 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3389

Query: 579  SPSST 583
            +P++T
Sbjct: 3390 TPTTT 3394



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2830 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2889

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2890 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2949

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2950 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3003

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3004 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3060

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3061 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3115

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3116 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3173

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3174 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3232

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3233 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3292

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3293 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3352

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3353 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3412

Query: 579  SPSST 583
            +P++T
Sbjct: 3413 TPTTT 3417



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2853 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2912

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2913 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2972

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2973 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3026

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3027 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3083

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3084 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3138

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3139 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3196

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3197 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3255

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3256 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3315

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3316 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3375

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3376 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3435

Query: 579  SPSST 583
            +P++T
Sbjct: 3436 TPTTT 3440



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2876 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2935

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2936 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2995

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 2996 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3049

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3050 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3106

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3107 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3161

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3162 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3219

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3220 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3278

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3279 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3338

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3339 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3398

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3399 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3458

Query: 579  SPSST 583
            +P++T
Sbjct: 3459 TPTTT 3463



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2899 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2958

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2959 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3018

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3019 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3072

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3073 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3129

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3130 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3184

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3185 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3242

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3243 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3301

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3302 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3361

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3362 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3421

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3422 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3481

Query: 579  SPSST 583
            +P++T
Sbjct: 3482 TPTTT 3486



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2922 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2981

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 2982 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3041

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3042 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3095

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3096 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3152

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3153 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3207

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3208 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3265

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3266 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3324

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3325 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3384

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3385 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3444

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3445 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3504

Query: 579  SPSST 583
            +P++T
Sbjct: 3505 TPTTT 3509



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2945 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3004

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3005 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3064

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3065 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3118

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3119 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3175

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3176 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3230

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3231 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3288

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3289 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3347

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3348 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3407

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3408 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3467

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3468 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3527

Query: 579  SPSST 583
            +P++T
Sbjct: 3528 TPTTT 3532



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2968 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3027

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3028 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3087

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3088 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3141

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3142 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3198

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3199 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3253

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3254 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3311

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3312 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3370

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3371 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3430

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3431 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3490

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3491 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3550

Query: 579  SPSST 583
            +P++T
Sbjct: 3551 TPTTT 3555



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 2991 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3050

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3051 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3110

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3111 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3164

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3165 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3221

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3222 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3276

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3277 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3334

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3335 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3393

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3394 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3453

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3454 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3513

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3514 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3573

Query: 579  SPSST 583
            +P++T
Sbjct: 3574 TPTTT 3578



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3014 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3073

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3074 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3133

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3134 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3187

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3188 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3244

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3245 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3299

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3300 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3357

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3358 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3416

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3417 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3476

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3477 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3536

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3537 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3596

Query: 579  SPSST 583
            +P++T
Sbjct: 3597 TPTTT 3601



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3037 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3096

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3097 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3156

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3157 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3210

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3211 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3267

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3268 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3322

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3323 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3380

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3381 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3439

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3440 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3499

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3500 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3559

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3560 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3619

Query: 579  SPSST 583
            +P++T
Sbjct: 3620 TPTTT 3624



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3060 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3119

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3120 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3179

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3180 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3233

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3234 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3290

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3291 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3345

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3346 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3403

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3404 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3462

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3463 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3522

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3523 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3582

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3583 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3642

Query: 579  SPSST 583
            +P++T
Sbjct: 3643 TPTTT 3647



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3083 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3142

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3143 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3202

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3203 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3256

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3257 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3313

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3314 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3368

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3369 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3426

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3427 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3485

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3486 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3545

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3546 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3605

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3606 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3665

Query: 579  SPSST 583
            +P++T
Sbjct: 3666 TPTTT 3670



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3106 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3165

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3166 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3225

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3226 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3279

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3280 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3336

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3337 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3391

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3392 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3449

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3450 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3508

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3509 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3568

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3569 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3628

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3629 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3688

Query: 579  SPSST 583
            +P++T
Sbjct: 3689 TPTTT 3693



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3129 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3188

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3189 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3248

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3249 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3302

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3303 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3359

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3360 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3414

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3415 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3472

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3473 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3531

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3532 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3591

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3592 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3651

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3652 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3711

Query: 579  SPSST 583
            +P++T
Sbjct: 3712 TPTTT 3716



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3152 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3211

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3212 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3271

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3272 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3325

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3326 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3382

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3383 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3437

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3438 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3495

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3496 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3554

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3555 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3614

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3674

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3675 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3734

Query: 579  SPSST 583
            +P++T
Sbjct: 3735 TPTTT 3739



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3175 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3234

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3235 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3294

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3295 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3348

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3349 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3405

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3406 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3460

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3461 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3518

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3519 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3577

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3578 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3637

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3638 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3697

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3698 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3757

Query: 579  SPSST 583
            +P++T
Sbjct: 3758 TPTTT 3762



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3198 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3257

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3258 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3317

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3318 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3371

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3372 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3428

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3429 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3483

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3484 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3541

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3542 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3600

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3601 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3660

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3661 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3720

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3721 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3780

Query: 579  SPSST 583
            +P++T
Sbjct: 3781 TPTTT 3785



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3221 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3280

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3281 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3340

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3341 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3394

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3395 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3451

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3452 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3506

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3507 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3564

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3565 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3623

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3624 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3683

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3684 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3743

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3744 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3803

Query: 579  SPSST 583
            +P++T
Sbjct: 3804 TPTTT 3808



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3244 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3303

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3304 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3363

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3364 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3417

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3418 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3474

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3475 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3529

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3530 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3587

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3588 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3646

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3647 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3706

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3707 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3766

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3767 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3826

Query: 579  SPSST 583
            +P++T
Sbjct: 3827 TPTTT 3831



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3267 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3326

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3327 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3386

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3387 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3440

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3441 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3497

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3498 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3552

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3553 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3610

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3611 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3669

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3670 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3729

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3730 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3789

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3790 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3849

Query: 579  SPSST 583
            +P++T
Sbjct: 3850 TPTTT 3854



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3290 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3349

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3350 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3409

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3410 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3463

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3464 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3520

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3521 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3575

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3576 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3633

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3634 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3692

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3693 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3752

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3753 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3812

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3813 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3872

Query: 579  SPSST 583
            +P++T
Sbjct: 3873 TPTTT 3877



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3313 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3372

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3373 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3432

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3433 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3486

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3487 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3543

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3544 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3598

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3599 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3656

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3657 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3715

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3716 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3775

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3776 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3835

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3836 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3895

Query: 579  SPSST 583
            +P++T
Sbjct: 3896 TPTTT 3900



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3336 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3395

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3396 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3455

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3456 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3509

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3510 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3566

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3567 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3621

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3622 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3679

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3680 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3738

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3739 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3798

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3799 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3858

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3859 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3918

Query: 579  SPSST 583
            +P++T
Sbjct: 3919 TPTTT 3923



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3359 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3418

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3419 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3478

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3479 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3532

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3533 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3589

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3590 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3644

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3645 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3702

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3703 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3761

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3762 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3821

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3822 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3881

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3882 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3941

Query: 579  SPSST 583
            +P++T
Sbjct: 3942 TPTTT 3946



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3382 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3441

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3442 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3501

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3502 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3555

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3556 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3612

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3613 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3667

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3668 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3725

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3726 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3784

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3785 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3844

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3845 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3904

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3905 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3964

Query: 579  SPSST 583
            +P++T
Sbjct: 3965 TPTTT 3969



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3405 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3464

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3465 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3524

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3525 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3578

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3579 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3635

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3636 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3690

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3691 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3748

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3749 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3807

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3808 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3867

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3868 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3927

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3928 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3987

Query: 579  SPSST 583
            +P++T
Sbjct: 3988 TPTTT 3992



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3428 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3487

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3488 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3547

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3548 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3601

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3602 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3658

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3659 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3713

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3714 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3771

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3772 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3830

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3831 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3890

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3891 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3950

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3951 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4010

Query: 579  SPSST 583
            +P++T
Sbjct: 4011 TPTTT 4015



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3451 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3510

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3511 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3570

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3571 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3624

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3625 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3681

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3682 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3736

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3737 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3794

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3795 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3853

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3854 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3913

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3914 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3973

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3974 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4033

Query: 579  SPSST 583
            +P++T
Sbjct: 4034 TPTTT 4038



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 116/605 (19%), Positives = 197/605 (32%), Gaps = 64/605 (10%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3474 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3533

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3534 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3593

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3594 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3647

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 3648 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 3704

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310
            P P G Q    P  TP            P     P   P++++   TP+P+  P+ +  P
Sbjct: 3705 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTP 3759

Query: 311  SLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367
            +   + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      + 
Sbjct: 3760 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVT 3817

Query: 368  APPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFS 414
              P+P     P + P++   T +P       Q P    +       +P P+P   Q P +
Sbjct: 3818 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTT 3876

Query: 415  PP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PL 471
             P   +  V+P+ TP     P+          +P  +P  + + T  P        P P 
Sbjct: 3877 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3936

Query: 472  QLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLA 528
                  P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+  
Sbjct: 3937 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3996

Query: 529  APLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSR 578
               +   P+P         P + T      P   G  T  + P   T  + P P P  ++
Sbjct: 3997 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4056

Query: 579  SPSST 583
            +P++T
Sbjct: 4057 TPTTT 4061



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 109/560 (19%), Positives = 188/560 (33%), Gaps = 64/560 (11%)

Query: 71   PESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE 130
            P   P    T T+ P  +       P    +  P ++P   + T  P P        +  
Sbjct: 1909 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 1968

Query: 131  ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
                    T  P  +          +  T  TP+P         GT+     P  +    
Sbjct: 1969 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTV 2022

Query: 191  PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG--- 247
             PT  P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   
Sbjct: 2023 TPTPTPTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQT 2079

Query: 248  PSARGTPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPL 295
            P+             P P G Q    P  TP            P     P   P++++  
Sbjct: 2080 PTTTPITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2136

Query: 296  ATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLAT 352
             TP+P+  P+ +  P+   + +     P+   T   +PT   +  T +  P+P  +P  T
Sbjct: 2137 VTPTPT--PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGT 2192

Query: 353  PPPQAPPALALPPLQAPPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQAP 400
              P   P      +   P+P     P + P++   T +P       Q P    +      
Sbjct: 2193 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTT 2251

Query: 401  FSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457
             +P P+P   Q P + P   +  V+P+ TP     P+          +P  +P  + + T
Sbjct: 2252 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2311

Query: 458  PPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSP 515
              P        P P       P   P   T  +   P+P  +  P   P + + ++  +P
Sbjct: 2312 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2371

Query: 516  L--ATPPPQAPPVLAAPLLQVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-R 563
                T  P   P+     +   P+P         P + T      P   G  T  + P  
Sbjct: 2372 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2431

Query: 564  LTLALAPGPPPPPSRSPSST 583
             T  + P P P  +++P++T
Sbjct: 2432 TTTTVTPTPTPTGTQTPTTT 2451



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 98/481 (20%), Positives = 169/481 (35%), Gaps = 63/481 (13%)

Query: 155  TSGPTPGTPSPAMARRS-----RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT 209
            T  PTP T +P     +        GT+     P  +     PT  P  + +  +   TT
Sbjct: 1890 TENPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 1949

Query: 210  EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQPKPK 266
              +      P+   G Q P +  ++++ T   +P  +G   P+             P P 
Sbjct: 1950 TTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2006

Query: 267  GLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQT 314
            G Q    P  TP            P     P   P++++   TP+P+  P+ +  P+   
Sbjct: 2007 GTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTPTTTP 2061

Query: 315  LPSPPATPPSQATTSLGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS 371
            + +     P+   T   +PT   +  T +  P+P  +P  T  P   P      +   P+
Sbjct: 2062 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPT 2119

Query: 372  P-----PASPPLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP-- 416
            P     P + P++   T +P       Q P    +       +P P+P   Q P + P  
Sbjct: 2120 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPIT 2178

Query: 417  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAK 475
             +  V+P+ TP     P+          +P  +P  + + T  P        P P     
Sbjct: 2179 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2238

Query: 476  PPPQAPPALATPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLL 532
              P   P   T  +   P+P  +  P   P + + ++  +P    T  P   P+     +
Sbjct: 2239 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2298

Query: 533  QVPPSP---------PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSS 582
               P+P         P + T      P   G  T  + P   T  + P P P  +++P++
Sbjct: 2299 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2358

Query: 583  T 583
            T
Sbjct: 2359 T 2359



 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 106/526 (20%), Positives = 181/526 (34%), Gaps = 69/526 (13%)

Query: 105  VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 164
            V+ P   + TT   P       I+   TV     T  P  +          +  T  TP+
Sbjct: 1879 VTQPTTMTTTTTENPTPPTTTPITTTTTV-----TPTPTPTGTQTPTTTPITTTTTVTPT 1933

Query: 165  PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 224
            P         GT+     P  +     PT  P  + +  +   TT  +      P+   G
Sbjct: 1934 PT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT---G 1984

Query: 225  LQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQPKPKGLQALRPPQVTP--- 278
             Q P +  ++++ T   +P  +G   P+             P P G Q    P  TP   
Sbjct: 1985 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT---PTTTPITT 2041

Query: 279  ---------PRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTS 329
                     P     P   P++++   TP+P+  P+ +  P+   + +     P+   T 
Sbjct: 2042 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTPTTTPITTTTTVTPTPTPTG 2099

Query: 330  LGSPT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPL 381
              +PT   +  T +  P+P  +P  T  P   P      +   P+P     P + P++  
Sbjct: 2100 TQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2157

Query: 382  ATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQA 431
             T +P       Q P    +       +P P+P   Q P + P   +  V+P+ TP    
Sbjct: 2158 TTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2216

Query: 432  PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQ 490
             P+          +P  +P  + + T  P        P P       P   P   T  + 
Sbjct: 2217 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2276

Query: 491  ALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP--------- 538
              P+P  +  P   P + + ++  +P    T  P   P+     +   P+P         
Sbjct: 2277 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2336

Query: 539  PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 583
            P + T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2337 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2382



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 118/582 (20%), Positives = 181/582 (31%), Gaps = 83/582 (14%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3865 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3924

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 3925 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3984

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 3985 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4038

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 4039 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 4095

Query: 263  PKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSPS--APPSPSA 308
            P P G Q    P  TP            P     P   P++++   TP+P+     +P+ 
Sbjct: 4096 PTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 4152

Query: 309  PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL-Q 367
             P   T    P   P+   T   +P +  T +  P+P  +   T PP       +  L  
Sbjct: 4153 TPITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTT 4211

Query: 368  APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 427
            + P P +S P +  +T SP   +   +  L         P ++   + P S P +P+ T 
Sbjct: 4212 SNPPPESSTPQTSRSTSSPLTESTTLLSTL--------PPAIEMTSTAPPSTPTAPTTTS 4263

Query: 428  PSQAPPSLAAPPLQVPPSPPASPPMSP--------SATPPPQAPPPLAAPPLQLAKPPPQ 479
                        L  PPS   SPP +P        S+ P P                P  
Sbjct: 4264 GGHT--------LSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLS 4315

Query: 480  APPALATPPLQALPS---------PPASFPGQAPF-------------SPSASLPM---S 514
             P  + T  L+  PS              PG+  +             S S +L     S
Sbjct: 4316 TPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWS 4375

Query: 515  PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 556
              +TP P   P  + P    P S P+ PT   P   P   PD
Sbjct: 4376 CPSTPSPTPTPSKSTPTPSKPSSTPSKPT---PGTKPPECPD 4414



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 101/477 (21%), Positives = 157/477 (32%), Gaps = 54/477 (11%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85
            TP P G+  P          V       G +              P   P    T T+ P
Sbjct: 3957 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4016

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
              +       P    +  P ++P   + T  P P        +          T  P  +
Sbjct: 4017 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 4076

Query: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
                      +  T  TP+P         GT+     P  +     PT  P  + +  + 
Sbjct: 4077 GTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4130

Query: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAHPSQ 262
              TT  +      P+   G Q P +  ++++ T   +P  +G   P+             
Sbjct: 4131 PITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 4187

Query: 263  PKPKGLQALRPPQVT-----------PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPS 311
            P P G Q   P   +           PP + + P     +SSPL   + S     + PP+
Sbjct: 4188 PTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL---TESTTLLSTLPPA 4244

Query: 312  LQ-TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP 370
            ++ T  +PP+TP +  TTS G  TL    S   SPP +P       +  A     +Q   
Sbjct: 4245 IEMTSTAPPSTPTAPTTTS-GGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTT 4303

Query: 371  SPPASPPLSPLATPS--------PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA----- 417
            +   +P  +PL+TPS        P   + L   +L   +  P        +         
Sbjct: 4304 TSAWTPTPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNC 4363

Query: 418  -----------SPPVSPSATP-PSQAPPSLAAPP-LQVPPSPPASPPMSPSATPPPQ 461
                       S P +PS TP PS++ P+ + P      P+P   PP  P   PP Q
Sbjct: 4364 SLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPPECPDFDPPRQ 4420


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  148 bits (373), Expect = 2e-35
 Identities = 177/688 (25%), Positives = 248/688 (36%), Gaps = 97/688 (14%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 200 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 247

Query: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
                T  +SAP      T + PA    +   P     P P ++   A  TT+  P   K
Sbjct: 248 ---APTTTKSAPT-----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 299

Query: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPR 182
                   T  +  A   PK  A +         PTP TP  PA   +  A  T      
Sbjct: 300 ----EPAPTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPAPTTP---KE 347

Query: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242
           PAP+A  +P    P++   +  +    EP+P   + PS     + PA  +  S+ T    
Sbjct: 348 PAPTAPKKPAPTTPKEPAPTTPK----EPAPTTTKEPSPTTP-KEPAPTTTKSAPTTTKE 402

Query: 243 PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302
           PA +      T  AP  P +P P   +   P   TP  K+ AP   P   +P  TP   A
Sbjct: 403 PAPTT-----TKSAPTTPKEPSPTTTK--EPAPTTP--KEPAPTT-PKKPAP-TTPKEPA 451

Query: 303 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 362
           P +P  P    T    P TP   A T+             P+ P     T P +  PA  
Sbjct: 452 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK--PAPT 509

Query: 363 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            P   AP +P    P +P   P+P  P A A +  + P   P +P   AP +P    P +
Sbjct: 510 TPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEP--APTTPKEPAPTTPKEPAPTT 566

Query: 423 PSATPPSQ---APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
           P  T P+      P+    P    P  PA   ++P+ T  P +            KP P 
Sbjct: 567 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT--------CDKPAPT 618

Query: 480 APPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            P   A T P +  P+ P      AP +P  + P + L  P P  P   A    ++ P+ 
Sbjct: 619 TPKGTAPTTPKEPAPTTPKE---PAPTTPKGTAPTT-LKEPAPTTPKKPAPK--ELAPTT 672

Query: 539 PASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
              PT     +P PT   +T+ + P+      P P  P   +P++  + P      S+ T
Sbjct: 673 TKGPTSTTSDKPAPTTPKETAPTTPK-----EPAPTTPKKPAPTTPETPPPTTSEVSTPT 727

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 657
           +T E    + S  E     S  P        P A    P         PG P    PA  
Sbjct: 728 TTKEPTTIHKSPDESTPELSAEPT-------PKALENSPK-------EPGVPTTKTPAAT 773

Query: 658 PGSADGLCTIYETE-----GPESATPAP 680
                       TE      PE+ T AP
Sbjct: 774 KPEMTTTAKDKTTERDLRTTPETTTAAP 801



 Score =  147 bits (372), Expect = 3e-35
 Identities = 171/671 (25%), Positives = 243/671 (36%), Gaps = 66/671 (9%)

Query: 55  RKPLAERAG-GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASG 113
           + P+ + AG G+       + P    T+ ++   S    +   AK  +P P   P   S 
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS---PKITTAKPINPRPSLPPN--SD 135

Query: 114 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 173
           T++     +  L ++ E TV   + T   K+++   G  + TS     T S         
Sbjct: 136 TSK-----ETSLTVNKETTVETKETTTTNKQTSTD-GKEKTTSAKE--TQSIEKTSAKDL 187

Query: 174 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
           A T   L +P P A     T+GP  ++++  E + T P   A   P      + P   ++
Sbjct: 188 APTSKVLAKPTPKAETT--TKGP--ALTTPKEPTPTTPKEPASTTP------KEPTPTTI 237

Query: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            S+ T    PA +      T  AP  P +P P   +   P   TP  K+ AP     +  
Sbjct: 238 KSAPTTPKEPAPTT-----TKSAPTTPKEPAPTTTK--EPAPTTP--KEPAPT---TTKE 285

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353
           P  T + SAP +P  P         P TP   A T+   PT        P+ P  P  T 
Sbjct: 286 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT--------PTTPKEPAPTT 337

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPL-ATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412
              AP     P   AP  P  + P  P   TP   AP          P  P P+    AP
Sbjct: 338 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAP 397

Query: 413 FS---PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLA 467
            +   P  +   S   TP   +P +   P    P  P  + P  P+ T P +  P  P  
Sbjct: 398 TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 457

Query: 468 APPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ-APP 525
             P    KP P  P   A T P +  P+ P       P   + + P  P  T P + AP 
Sbjct: 458 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 517

Query: 526 VLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
               P    P  P P +P   AP  P  P P T+   P  T    P P  P   +P +T 
Sbjct: 518 TPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTP 575

Query: 585 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFR 643
            G         A +TP++       P+  A  +           PA  + +G AP     
Sbjct: 576 KGTAPTTLKEPAPTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE 630

Query: 644 GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGA 700
            AP  P    P T  G+A    T+ E        PAP  L P  + G   T+  K A   
Sbjct: 631 PAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 688

Query: 701 GAGASSRSPKQ 711
               +  +PK+
Sbjct: 689 PKETAPTTPKE 699



 Score =  146 bits (369), Expect = 7e-35
 Identities = 165/612 (26%), Positives = 225/612 (36%), Gaps = 86/612 (14%)

Query: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
           ET  +G A   PK    +    ++ +  TP  P+P   + +     E     PAP+    
Sbjct: 202 ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTTIKSAPTTPKE-----PAPTTTKS 254

Query: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250
            PT  P++   +    +T EP+P   + P A    + PA  +  S+ T    PA + P  
Sbjct: 255 APTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPK- 307

Query: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA-------TPSPSAP 303
           +  P  P  P+   PK      P +  P  K+ AP   P   +P A       TP   AP
Sbjct: 308 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP 366

Query: 304 PSPSAPPSLQTLPSPPATPPSQA-TTSLGSPTLQ-----ATHSFLPSPPLSPLATPPPQA 357
            +P  P    T    P TP   A TT+  +PT        T    P+ P  P  +P    
Sbjct: 367 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP--SPTTTK 424

Query: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417
            PA   P   AP +P    P +P   P+P  P   A    + P   P +P   AP +P  
Sbjct: 425 EPAPTTPKEPAPTTPKKPAPTTP-KEPAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKE 481

Query: 418 SPPVSPS----ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLAAPPL 471
           + P +P      TP   AP +   P    P     + P  P+ T P +  P  P AA P 
Sbjct: 482 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 541

Query: 472 QLAKPPPQAP--PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529
              +P P  P  PA  TP   A  +P  + P     +   +L      TP   AP  LA 
Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 601

Query: 530 PLLQVPPSP------PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
              + P S       P +P   AP  P  P P T            P P  P   +P+ T
Sbjct: 602 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-T 651

Query: 584 LSGPDLAGHSSSATSTPEELRGYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPL 640
           L  P     ++     P+EL    + GP    +  P P    E A   P    + PAP  
Sbjct: 652 LKEP---APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT- 703

Query: 641 AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE-------------SATPAPGALDPGP 687
                P  P P  P T P +   + T   T+ P              SA P P AL+  P
Sbjct: 704 ----TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 759

Query: 688 -SPGTSGGKAAA 698
             PG    K  A
Sbjct: 760 KEPGVPTTKTPA 771



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 142/603 (23%), Positives = 204/603 (33%), Gaps = 68/603 (11%)

Query: 7   KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
           K  A    + PA  AP    P  P  P P  P  PA       +    ++P A       
Sbjct: 338 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP-APTTTKSA 396

Query: 67  GATIPESAP---RAGPTRTSRPPASGRGERAP-----PAKNTSPGPV-SSPGRASGTT-- 115
             T  E AP   ++ PT    P  +   E AP     PA  T   P  ++P   + TT  
Sbjct: 397 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 456

Query: 116 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP---TPGTPS-PAMARRS 171
            P P   K        T  +  A   PK +A +   +   + P    P TP  PA     
Sbjct: 457 EPAPTTTK----KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 512

Query: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
             A T    P P     P P T        +A+ ++  EP+P   + P A    + PA  
Sbjct: 513 ELAPTTPEEPTPTTPEEPAPTTP------KAAAPNTPKEPAPTTPKEP-APTTPKEPAPT 565

Query: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
           +   +A   ++P  + P+    P AP  P +P PK L      + T    D      P  
Sbjct: 566 TPKETAP--TTPKGTAPTTLKEP-APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 622

Query: 292 SSPLAT--PSPSAP--PSPSAPPSLQ--TLPSP-PATPPSQATTSLGSPTLQ---ATHSF 341
           ++P     P+P+ P  P+P+ P      TL  P P TP   A   L   T +   +T S 
Sbjct: 623 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 682

Query: 342 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401
            P+P       P     PA   P   AP +P   PP +   +          +H      
Sbjct: 683 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 742

Query: 402 SPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPP 451
           +P  S  P  +A  + P  P V  + TP +  P        +         P +  A+P 
Sbjct: 743 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802

Query: 452 MSP--SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS--- 506
           M+   + T        + A   Q+     Q         L+     P     +   +   
Sbjct: 803 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 862

Query: 507 ----------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGP 555
                     P      S   TP PQ P    AP        P + P ++ P+  PTP  
Sbjct: 863 IMNKPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRK 920

Query: 556 DTS 558
            TS
Sbjct: 921 MTS 923


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  148 bits (373), Expect = 2e-35
 Identities = 177/688 (25%), Positives = 248/688 (36%), Gaps = 97/688 (14%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 241 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 288

Query: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
                T  +SAP      T + PA    +   P     P P ++   A  TT+  P   K
Sbjct: 289 ---APTTTKSAPT-----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 340

Query: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPR 182
                   T  +  A   PK  A +         PTP TP  PA   +  A  T      
Sbjct: 341 ----EPAPTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPAPTTP---KE 388

Query: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242
           PAP+A  +P    P++   +  +    EP+P   + PS     + PA  +  S+ T    
Sbjct: 389 PAPTAPKKPAPTTPKEPAPTTPK----EPAPTTTKEPSPTTP-KEPAPTTTKSAPTTTKE 443

Query: 243 PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302
           PA +      T  AP  P +P P   +   P   TP  K+ AP   P   +P  TP   A
Sbjct: 444 PAPTT-----TKSAPTTPKEPSPTTTK--EPAPTTP--KEPAPTT-PKKPAP-TTPKEPA 492

Query: 303 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 362
           P +P  P    T    P TP   A T+             P+ P     T P +  PA  
Sbjct: 493 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK--PAPT 550

Query: 363 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            P   AP +P    P +P   P+P  P A A +  + P   P +P   AP +P    P +
Sbjct: 551 TPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEP--APTTPKEPAPTTPKEPAPTT 607

Query: 423 PSATPPSQ---APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
           P  T P+      P+    P    P  PA   ++P+ T  P +            KP P 
Sbjct: 608 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT--------CDKPAPT 659

Query: 480 APPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            P   A T P +  P+ P      AP +P  + P + L  P P  P   A    ++ P+ 
Sbjct: 660 TPKGTAPTTPKEPAPTTPKE---PAPTTPKGTAPTT-LKEPAPTTPKKPAPK--ELAPTT 713

Query: 539 PASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
              PT     +P PT   +T+ + P+      P P  P   +P++  + P      S+ T
Sbjct: 714 TKGPTSTTSDKPAPTTPKETAPTTPK-----EPAPTTPKKPAPTTPETPPPTTSEVSTPT 768

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 657
           +T E    + S  E     S  P        P A    P         PG P    PA  
Sbjct: 769 TTKEPTTIHKSPDESTPELSAEPT-------PKALENSPK-------EPGVPTTKTPAAT 814

Query: 658 PGSADGLCTIYETE-----GPESATPAP 680
                       TE      PE+ T AP
Sbjct: 815 KPEMTTTAKDKTTERDLRTTPETTTAAP 842



 Score =  147 bits (372), Expect = 3e-35
 Identities = 171/671 (25%), Positives = 243/671 (36%), Gaps = 66/671 (9%)

Query: 55  RKPLAERAG-GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASG 113
           + P+ + AG G+       + P    T+ ++   S    +   AK  +P P   P   S 
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS---PKITTAKPINPRPSLPPN--SD 176

Query: 114 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 173
           T++     +  L ++ E TV   + T   K+++   G  + TS     T S         
Sbjct: 177 TSK-----ETSLTVNKETTVETKETTTTNKQTSTD-GKEKTTSAKE--TQSIEKTSAKDL 228

Query: 174 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
           A T   L +P P A     T+GP  ++++  E + T P   A   P      + P   ++
Sbjct: 229 APTSKVLAKPTPKAETT--TKGP--ALTTPKEPTPTTPKEPASTTP------KEPTPTTI 278

Query: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            S+ T    PA +      T  AP  P +P P   +   P   TP  K+ AP     +  
Sbjct: 279 KSAPTTPKEPAPTT-----TKSAPTTPKEPAPTTTK--EPAPTTP--KEPAPT---TTKE 326

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353
           P  T + SAP +P  P         P TP   A T+   PT        P+ P  P  T 
Sbjct: 327 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT--------PTTPKEPAPTT 378

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPL-ATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412
              AP     P   AP  P  + P  P   TP   AP          P  P P+    AP
Sbjct: 379 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAP 438

Query: 413 FS---PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLA 467
            +   P  +   S   TP   +P +   P    P  P  + P  P+ T P +  P  P  
Sbjct: 439 TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 498

Query: 468 APPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ-APP 525
             P    KP P  P   A T P +  P+ P       P   + + P  P  T P + AP 
Sbjct: 499 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 558

Query: 526 VLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
               P    P  P P +P   AP  P  P P T+   P  T    P P  P   +P +T 
Sbjct: 559 TPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTP 616

Query: 585 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFR 643
            G         A +TP++       P+  A  +           PA  + +G AP     
Sbjct: 617 KGTAPTTLKEPAPTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE 671

Query: 644 GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGA 700
            AP  P    P T  G+A    T+ E        PAP  L P  + G   T+  K A   
Sbjct: 672 PAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 729

Query: 701 GAGASSRSPKQ 711
               +  +PK+
Sbjct: 730 PKETAPTTPKE 740



 Score =  146 bits (369), Expect = 7e-35
 Identities = 165/612 (26%), Positives = 225/612 (36%), Gaps = 86/612 (14%)

Query: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
           ET  +G A   PK    +    ++ +  TP  P+P   + +     E     PAP+    
Sbjct: 243 ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTTIKSAPTTPKE-----PAPTTTKS 295

Query: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250
            PT  P++   +    +T EP+P   + P A    + PA  +  S+ T    PA + P  
Sbjct: 296 APTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPK- 348

Query: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA-------TPSPSAP 303
           +  P  P  P+   PK      P +  P  K+ AP   P   +P A       TP   AP
Sbjct: 349 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP 407

Query: 304 PSPSAPPSLQTLPSPPATPPSQA-TTSLGSPTLQ-----ATHSFLPSPPLSPLATPPPQA 357
            +P  P    T    P TP   A TT+  +PT        T    P+ P  P  +P    
Sbjct: 408 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP--SPTTTK 465

Query: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417
            PA   P   AP +P    P +P   P+P  P   A    + P   P +P   AP +P  
Sbjct: 466 EPAPTTPKEPAPTTPKKPAPTTP-KEPAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKE 522

Query: 418 SPPVSPS----ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLAAPPL 471
           + P +P      TP   AP +   P    P     + P  P+ T P +  P  P AA P 
Sbjct: 523 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 582

Query: 472 QLAKPPPQAP--PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529
              +P P  P  PA  TP   A  +P  + P     +   +L      TP   AP  LA 
Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 642

Query: 530 PLLQVPPSP------PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
              + P S       P +P   AP  P  P P T            P P  P   +P+ T
Sbjct: 643 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-T 692

Query: 584 LSGPDLAGHSSSATSTPEELRGYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPL 640
           L  P     ++     P+EL    + GP    +  P P    E A   P    + PAP  
Sbjct: 693 LKEP---APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT- 744

Query: 641 AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE-------------SATPAPGALDPGP 687
                P  P P  P T P +   + T   T+ P              SA P P AL+  P
Sbjct: 745 ----TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 800

Query: 688 -SPGTSGGKAAA 698
             PG    K  A
Sbjct: 801 KEPGVPTTKTPA 812



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 142/603 (23%), Positives = 204/603 (33%), Gaps = 68/603 (11%)

Query: 7   KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
           K  A    + PA  AP    P  P  P P  P  PA       +    ++P A       
Sbjct: 379 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP-APTTTKSA 437

Query: 67  GATIPESAP---RAGPTRTSRPPASGRGERAP-----PAKNTSPGPV-SSPGRASGTT-- 115
             T  E AP   ++ PT    P  +   E AP     PA  T   P  ++P   + TT  
Sbjct: 438 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 497

Query: 116 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP---TPGTPS-PAMARRS 171
            P P   K        T  +  A   PK +A +   +   + P    P TP  PA     
Sbjct: 498 EPAPTTTK----KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 553

Query: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
             A T    P P     P P T        +A+ ++  EP+P   + P A    + PA  
Sbjct: 554 ELAPTTPEEPTPTTPEEPAPTTP------KAAAPNTPKEPAPTTPKEP-APTTPKEPAPT 606

Query: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
           +   +A   ++P  + P+    P AP  P +P PK L      + T    D      P  
Sbjct: 607 TPKETAP--TTPKGTAPTTLKEP-APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 663

Query: 292 SSPLAT--PSPSAP--PSPSAPPSLQ--TLPSP-PATPPSQATTSLGSPTLQ---ATHSF 341
           ++P     P+P+ P  P+P+ P      TL  P P TP   A   L   T +   +T S 
Sbjct: 664 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 723

Query: 342 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401
            P+P       P     PA   P   AP +P   PP +   +          +H      
Sbjct: 724 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 783

Query: 402 SPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPP 451
           +P  S  P  +A  + P  P V  + TP +  P        +         P +  A+P 
Sbjct: 784 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843

Query: 452 MSP--SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS--- 506
           M+   + T        + A   Q+     Q         L+     P     +   +   
Sbjct: 844 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 903

Query: 507 ----------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGP 555
                     P      S   TP PQ P    AP        P + P ++ P+  PTP  
Sbjct: 904 IMNKPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRK 961

Query: 556 DTS 558
            TS
Sbjct: 962 MTS 964


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  148 bits (373), Expect = 2e-35
 Identities = 177/688 (25%), Positives = 248/688 (36%), Gaps = 97/688 (14%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 293 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 340

Query: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
                T  +SAP      T + PA    +   P     P P ++   A  TT+  P   K
Sbjct: 341 ---APTTTKSAPT-----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 392

Query: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPR 182
                   T  +  A   PK  A +         PTP TP  PA   +  A  T      
Sbjct: 393 ----EPAPTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPAPTTP---KE 440

Query: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242
           PAP+A  +P    P++   +  +    EP+P   + PS     + PA  +  S+ T    
Sbjct: 441 PAPTAPKKPAPTTPKEPAPTTPK----EPAPTTTKEPSPTTP-KEPAPTTTKSAPTTTKE 495

Query: 243 PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302
           PA +      T  AP  P +P P   +   P   TP  K+ AP   P   +P  TP   A
Sbjct: 496 PAPTT-----TKSAPTTPKEPSPTTTK--EPAPTTP--KEPAPTT-PKKPAP-TTPKEPA 544

Query: 303 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 362
           P +P  P    T    P TP   A T+             P+ P     T P +  PA  
Sbjct: 545 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK--PAPT 602

Query: 363 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            P   AP +P    P +P   P+P  P A A +  + P   P +P   AP +P    P +
Sbjct: 603 TPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEP--APTTPKEPAPTTPKEPAPTT 659

Query: 423 PSATPPSQ---APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
           P  T P+      P+    P    P  PA   ++P+ T  P +            KP P 
Sbjct: 660 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT--------CDKPAPT 711

Query: 480 APPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            P   A T P +  P+ P      AP +P  + P + L  P P  P   A    ++ P+ 
Sbjct: 712 TPKGTAPTTPKEPAPTTPKE---PAPTTPKGTAPTT-LKEPAPTTPKKPAPK--ELAPTT 765

Query: 539 PASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
              PT     +P PT   +T+ + P+      P P  P   +P++  + P      S+ T
Sbjct: 766 TKGPTSTTSDKPAPTTPKETAPTTPK-----EPAPTTPKKPAPTTPETPPPTTSEVSTPT 820

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 657
           +T E    + S  E     S  P        P A    P         PG P    PA  
Sbjct: 821 TTKEPTTIHKSPDESTPELSAEPT-------PKALENSPK-------EPGVPTTKTPAAT 866

Query: 658 PGSADGLCTIYETE-----GPESATPAP 680
                       TE      PE+ T AP
Sbjct: 867 KPEMTTTAKDKTTERDLRTTPETTTAAP 894



 Score =  147 bits (372), Expect = 3e-35
 Identities = 171/671 (25%), Positives = 243/671 (36%), Gaps = 66/671 (9%)

Query: 55  RKPLAERAG-GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASG 113
           + P+ + AG G+       + P    T+ ++   S    +   AK  +P P   P   S 
Sbjct: 174 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS---PKITTAKPINPRPSLPPN--SD 228

Query: 114 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 173
           T++     +  L ++ E TV   + T   K+++   G  + TS     T S         
Sbjct: 229 TSK-----ETSLTVNKETTVETKETTTTNKQTSTD-GKEKTTSAKE--TQSIEKTSAKDL 280

Query: 174 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
           A T   L +P P A     T+GP  ++++  E + T P   A   P      + P   ++
Sbjct: 281 APTSKVLAKPTPKAETT--TKGP--ALTTPKEPTPTTPKEPASTTP------KEPTPTTI 330

Query: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            S+ T    PA +      T  AP  P +P P   +   P   TP  K+ AP     +  
Sbjct: 331 KSAPTTPKEPAPTT-----TKSAPTTPKEPAPTTTK--EPAPTTP--KEPAPT---TTKE 378

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353
           P  T + SAP +P  P         P TP   A T+   PT        P+ P  P  T 
Sbjct: 379 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT--------PTTPKEPAPTT 430

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPL-ATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412
              AP     P   AP  P  + P  P   TP   AP          P  P P+    AP
Sbjct: 431 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAP 490

Query: 413 FS---PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLA 467
            +   P  +   S   TP   +P +   P    P  P  + P  P+ T P +  P  P  
Sbjct: 491 TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 550

Query: 468 APPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ-APP 525
             P    KP P  P   A T P +  P+ P       P   + + P  P  T P + AP 
Sbjct: 551 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 610

Query: 526 VLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
               P    P  P P +P   AP  P  P P T+   P  T    P P  P   +P +T 
Sbjct: 611 TPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTP 668

Query: 585 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFR 643
            G         A +TP++       P+  A  +           PA  + +G AP     
Sbjct: 669 KGTAPTTLKEPAPTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE 723

Query: 644 GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGA 700
            AP  P    P T  G+A    T+ E        PAP  L P  + G   T+  K A   
Sbjct: 724 PAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 781

Query: 701 GAGASSRSPKQ 711
               +  +PK+
Sbjct: 782 PKETAPTTPKE 792



 Score =  146 bits (369), Expect = 7e-35
 Identities = 165/612 (26%), Positives = 225/612 (36%), Gaps = 86/612 (14%)

Query: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
           ET  +G A   PK    +    ++ +  TP  P+P   + +     E     PAP+    
Sbjct: 295 ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTTIKSAPTTPKE-----PAPTTTKS 347

Query: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250
            PT  P++   +    +T EP+P   + P A    + PA  +  S+ T    PA + P  
Sbjct: 348 APTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPK- 400

Query: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA-------TPSPSAP 303
           +  P  P  P+   PK      P +  P  K+ AP   P   +P A       TP   AP
Sbjct: 401 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP 459

Query: 304 PSPSAPPSLQTLPSPPATPPSQA-TTSLGSPTLQ-----ATHSFLPSPPLSPLATPPPQA 357
            +P  P    T    P TP   A TT+  +PT        T    P+ P  P  +P    
Sbjct: 460 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP--SPTTTK 517

Query: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417
            PA   P   AP +P    P +P   P+P  P   A    + P   P +P   AP +P  
Sbjct: 518 EPAPTTPKEPAPTTPKKPAPTTP-KEPAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKE 574

Query: 418 SPPVSPS----ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLAAPPL 471
           + P +P      TP   AP +   P    P     + P  P+ T P +  P  P AA P 
Sbjct: 575 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 634

Query: 472 QLAKPPPQAP--PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529
              +P P  P  PA  TP   A  +P  + P     +   +L      TP   AP  LA 
Sbjct: 635 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 694

Query: 530 PLLQVPPSP------PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
              + P S       P +P   AP  P  P P T            P P  P   +P+ T
Sbjct: 695 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-T 744

Query: 584 LSGPDLAGHSSSATSTPEELRGYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPL 640
           L  P     ++     P+EL    + GP    +  P P    E A   P    + PAP  
Sbjct: 745 LKEP---APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT- 796

Query: 641 AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE-------------SATPAPGALDPGP 687
                P  P P  P T P +   + T   T+ P              SA P P AL+  P
Sbjct: 797 ----TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 852

Query: 688 -SPGTSGGKAAA 698
             PG    K  A
Sbjct: 853 KEPGVPTTKTPA 864



 Score =  114 bits (284), Expect = 5e-25
 Identities = 121/543 (22%), Positives = 183/543 (33%), Gaps = 55/543 (10%)

Query: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR----------PSAGGGLQ 226
           EV  P   PS++  PP  G  +++ S ++ S   P+    ++           S     +
Sbjct: 65  EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQE 124

Query: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 286
             +S S SSS++ +     S  SA           +   K     +P    P   +A   
Sbjct: 125 SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 184

Query: 287 L-----------------GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTS 329
           L                   +S+SP  T +    P PS PP+  T      T   + T  
Sbjct: 185 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 244

Query: 330 LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 389
               T     +               +   A     ++   +   +P    LA P+P+A 
Sbjct: 245 TKETTTTNKQTSTDG---------KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 295

Query: 390 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
                  L  P  P P+ P +    P ++ P  P+ T    AP +   P      S P +
Sbjct: 296 TTTKGPALTTPKEPTPTTPKE----PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 351

Query: 450 P-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
           P   +P+ T  P    P    P    +P P    +  T P +  P+ P       P  P+
Sbjct: 352 PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411

Query: 509 ASLPMSPLATPPPQAPPVLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLA 567
            + P  P  T P +  P    P    P  P P +P   AP  P  P P T+   P  T  
Sbjct: 412 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP-TTPKEPAPTTT 470

Query: 568 LAPGPPPPPSRSPSSTLSGPDLAGH-----SSSATSTPEE------LRGYDSGPEGGAAA 616
             P P  P   +P++T S P          + SA +TP+E           + P+  A  
Sbjct: 471 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530

Query: 617 SPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPES 675
           +P   A      PA  + + PAP    + AP  P    P T   +A           PE 
Sbjct: 531 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 590

Query: 676 ATP 678
             P
Sbjct: 591 LAP 593



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 142/603 (23%), Positives = 204/603 (33%), Gaps = 68/603 (11%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
            K  A    + PA  AP    P  P  P P  P  PA       +    ++P A       
Sbjct: 431  KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP-APTTTKSA 489

Query: 67   GATIPESAP---RAGPTRTSRPPASGRGERAP-----PAKNTSPGPV-SSPGRASGTT-- 115
              T  E AP   ++ PT    P  +   E AP     PA  T   P  ++P   + TT  
Sbjct: 490  PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 549

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP---TPGTPS-PAMARRS 171
             P P   K        T  +  A   PK +A +   +   + P    P TP  PA     
Sbjct: 550  EPAPTTTK----KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 605

Query: 172  RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
              A T    P P     P P T        +A+ ++  EP+P   + P A    + PA  
Sbjct: 606  ELAPTTPEEPTPTTPEEPAPTTP------KAAAPNTPKEPAPTTPKEP-APTTPKEPAPT 658

Query: 232  SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
            +   +A   ++P  + P+    P AP  P +P PK L      + T    D      P  
Sbjct: 659  TPKETAP--TTPKGTAPTTLKEP-APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 715

Query: 292  SSPLAT--PSPSAP--PSPSAPPSLQ--TLPSP-PATPPSQATTSLGSPTLQ---ATHSF 341
            ++P     P+P+ P  P+P+ P      TL  P P TP   A   L   T +   +T S 
Sbjct: 716  TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 775

Query: 342  LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401
             P+P       P     PA   P   AP +P   PP +   +          +H      
Sbjct: 776  KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 835

Query: 402  SPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPP 451
            +P  S  P  +A  + P  P V  + TP +  P        +         P +  A+P 
Sbjct: 836  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895

Query: 452  MSP--SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS--- 506
            M+   + T        + A   Q+     Q         L+     P     +   +   
Sbjct: 896  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955

Query: 507  ----------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGP 555
                      P      S   TP PQ P    AP        P + P ++ P+  PTP  
Sbjct: 956  IMNKPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRK 1013

Query: 556  DTS 558
             TS
Sbjct: 1014 MTS 1016


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  148 bits (373), Expect = 2e-35
 Identities = 177/688 (25%), Positives = 248/688 (36%), Gaps = 97/688 (14%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 334 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 381

Query: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
                T  +SAP      T + PA    +   P     P P ++   A  TT+  P   K
Sbjct: 382 ---APTTTKSAPT-----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 433

Query: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPR 182
                   T  +  A   PK  A +         PTP TP  PA   +  A  T      
Sbjct: 434 ----EPAPTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPAPTTP---KE 481

Query: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242
           PAP+A  +P    P++   +  +    EP+P   + PS     + PA  +  S+ T    
Sbjct: 482 PAPTAPKKPAPTTPKEPAPTTPK----EPAPTTTKEPSPTTP-KEPAPTTTKSAPTTTKE 536

Query: 243 PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302
           PA +      T  AP  P +P P   +   P   TP  K+ AP   P   +P  TP   A
Sbjct: 537 PAPTT-----TKSAPTTPKEPSPTTTK--EPAPTTP--KEPAPTT-PKKPAP-TTPKEPA 585

Query: 303 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 362
           P +P  P    T    P TP   A T+             P+ P     T P +  PA  
Sbjct: 586 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK--PAPT 643

Query: 363 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            P   AP +P    P +P   P+P  P A A +  + P   P +P   AP +P    P +
Sbjct: 644 TPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEP--APTTPKEPAPTTPKEPAPTT 700

Query: 423 PSATPPSQ---APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
           P  T P+      P+    P    P  PA   ++P+ T  P +            KP P 
Sbjct: 701 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT--------CDKPAPT 752

Query: 480 APPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            P   A T P +  P+ P      AP +P  + P + L  P P  P   A    ++ P+ 
Sbjct: 753 TPKGTAPTTPKEPAPTTPKE---PAPTTPKGTAPTT-LKEPAPTTPKKPAPK--ELAPTT 806

Query: 539 PASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
              PT     +P PT   +T+ + P+      P P  P   +P++  + P      S+ T
Sbjct: 807 TKGPTSTTSDKPAPTTPKETAPTTPK-----EPAPTTPKKPAPTTPETPPPTTSEVSTPT 861

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 657
           +T E    + S  E     S  P        P A    P         PG P    PA  
Sbjct: 862 TTKEPTTIHKSPDESTPELSAEPT-------PKALENSPK-------EPGVPTTKTPAAT 907

Query: 658 PGSADGLCTIYETE-----GPESATPAP 680
                       TE      PE+ T AP
Sbjct: 908 KPEMTTTAKDKTTERDLRTTPETTTAAP 935



 Score =  147 bits (372), Expect = 3e-35
 Identities = 171/671 (25%), Positives = 243/671 (36%), Gaps = 66/671 (9%)

Query: 55  RKPLAERAG-GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASG 113
           + P+ + AG G+       + P    T+ ++   S    +   AK  +P P   P   S 
Sbjct: 215 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS---PKITTAKPINPRPSLPPN--SD 269

Query: 114 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 173
           T++     +  L ++ E TV   + T   K+++   G  + TS     T S         
Sbjct: 270 TSK-----ETSLTVNKETTVETKETTTTNKQTSTD-GKEKTTSAKE--TQSIEKTSAKDL 321

Query: 174 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
           A T   L +P P A     T+GP  ++++  E + T P   A   P      + P   ++
Sbjct: 322 APTSKVLAKPTPKAETT--TKGP--ALTTPKEPTPTTPKEPASTTP------KEPTPTTI 371

Query: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            S+ T    PA +      T  AP  P +P P   +   P   TP  K+ AP     +  
Sbjct: 372 KSAPTTPKEPAPTT-----TKSAPTTPKEPAPTTTK--EPAPTTP--KEPAPT---TTKE 419

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353
           P  T + SAP +P  P         P TP   A T+   PT        P+ P  P  T 
Sbjct: 420 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT--------PTTPKEPAPTT 471

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPL-ATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412
              AP     P   AP  P  + P  P   TP   AP          P  P P+    AP
Sbjct: 472 KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAP 531

Query: 413 FS---PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLA 467
            +   P  +   S   TP   +P +   P    P  P  + P  P+ T P +  P  P  
Sbjct: 532 TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 591

Query: 468 APPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ-APP 525
             P    KP P  P   A T P +  P+ P       P   + + P  P  T P + AP 
Sbjct: 592 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 651

Query: 526 VLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
               P    P  P P +P   AP  P  P P T+   P  T    P P  P   +P +T 
Sbjct: 652 TPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTP 709

Query: 585 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFR 643
            G         A +TP++       P+  A  +           PA  + +G AP     
Sbjct: 710 KGTAPTTLKEPAPTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE 764

Query: 644 GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGA 700
            AP  P    P T  G+A    T+ E        PAP  L P  + G   T+  K A   
Sbjct: 765 PAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 822

Query: 701 GAGASSRSPKQ 711
               +  +PK+
Sbjct: 823 PKETAPTTPKE 833



 Score =  146 bits (369), Expect = 7e-35
 Identities = 165/612 (26%), Positives = 225/612 (36%), Gaps = 86/612 (14%)

Query: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
           ET  +G A   PK    +    ++ +  TP  P+P   + +     E     PAP+    
Sbjct: 336 ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTTIKSAPTTPKE-----PAPTTTKS 388

Query: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250
            PT  P++   +    +T EP+P   + P A    + PA  +  S+ T    PA + P  
Sbjct: 389 APTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPK- 441

Query: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA-------TPSPSAP 303
           +  P  P  P+   PK      P +  P  K+ AP   P   +P A       TP   AP
Sbjct: 442 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP 500

Query: 304 PSPSAPPSLQTLPSPPATPPSQA-TTSLGSPTLQ-----ATHSFLPSPPLSPLATPPPQA 357
            +P  P    T    P TP   A TT+  +PT        T    P+ P  P  +P    
Sbjct: 501 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP--SPTTTK 558

Query: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417
            PA   P   AP +P    P +P   P+P  P   A    + P   P +P   AP +P  
Sbjct: 559 EPAPTTPKEPAPTTPKKPAPTTP-KEPAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKE 615

Query: 418 SPPVSPS----ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLAAPPL 471
           + P +P      TP   AP +   P    P     + P  P+ T P +  P  P AA P 
Sbjct: 616 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 675

Query: 472 QLAKPPPQAP--PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529
              +P P  P  PA  TP   A  +P  + P     +   +L      TP   AP  LA 
Sbjct: 676 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 735

Query: 530 PLLQVPPSP------PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
              + P S       P +P   AP  P  P P T            P P  P   +P+ T
Sbjct: 736 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-T 785

Query: 584 LSGPDLAGHSSSATSTPEELRGYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPL 640
           L  P     ++     P+EL    + GP    +  P P    E A   P    + PAP  
Sbjct: 786 LKEP---APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT- 837

Query: 641 AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE-------------SATPAPGALDPGP 687
                P  P P  P T P +   + T   T+ P              SA P P AL+  P
Sbjct: 838 ----TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 893

Query: 688 -SPGTSGGKAAA 698
             PG    K  A
Sbjct: 894 KEPGVPTTKTPA 905



 Score =  114 bits (284), Expect = 5e-25
 Identities = 121/543 (22%), Positives = 183/543 (33%), Gaps = 55/543 (10%)

Query: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR----------PSAGGGLQ 226
           EV  P   PS++  PP  G  +++ S ++ S   P+    ++           S     +
Sbjct: 106 EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQE 165

Query: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 286
             +S S SSS++ +     S  SA           +   K     +P    P   +A   
Sbjct: 166 SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 225

Query: 287 L-----------------GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTS 329
           L                   +S+SP  T +    P PS PP+  T      T   + T  
Sbjct: 226 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 285

Query: 330 LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 389
               T     +               +   A     ++   +   +P    LA P+P+A 
Sbjct: 286 TKETTTTNKQTSTDG---------KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 336

Query: 390 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
                  L  P  P P+ P +    P ++ P  P+ T    AP +   P      S P +
Sbjct: 337 TTTKGPALTTPKEPTPTTPKE----PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 392

Query: 450 P-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
           P   +P+ T  P    P    P    +P P    +  T P +  P+ P       P  P+
Sbjct: 393 PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452

Query: 509 ASLPMSPLATPPPQAPPVLAAPLLQVPPSP-PASPTLQAPRRPPTPGPDTSVSGPRLTLA 567
            + P  P  T P +  P    P    P  P P +P   AP  P  P P T+   P  T  
Sbjct: 453 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP-TTPKEPAPTTT 511

Query: 568 LAPGPPPPPSRSPSSTLSGPDLAGH-----SSSATSTPEE------LRGYDSGPEGGAAA 616
             P P  P   +P++T S P          + SA +TP+E           + P+  A  
Sbjct: 512 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571

Query: 617 SPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPES 675
           +P   A      PA  + + PAP    + AP  P    P T   +A           PE 
Sbjct: 572 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 631

Query: 676 ATP 678
             P
Sbjct: 632 LAP 634



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 142/603 (23%), Positives = 204/603 (33%), Gaps = 68/603 (11%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
            K  A    + PA  AP    P  P  P P  P  PA       +    ++P A       
Sbjct: 472  KEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP-APTTTKSA 530

Query: 67   GATIPESAP---RAGPTRTSRPPASGRGERAP-----PAKNTSPGPV-SSPGRASGTT-- 115
              T  E AP   ++ PT    P  +   E AP     PA  T   P  ++P   + TT  
Sbjct: 531  PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 590

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP---TPGTPS-PAMARRS 171
             P P   K        T  +  A   PK +A +   +   + P    P TP  PA     
Sbjct: 591  EPAPTTTK----KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 646

Query: 172  RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
              A T    P P     P P T        +A+ ++  EP+P   + P A    + PA  
Sbjct: 647  ELAPTTPEEPTPTTPEEPAPTTP------KAAAPNTPKEPAPTTPKEP-APTTPKEPAPT 699

Query: 232  SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
            +   +A   ++P  + P+    P AP  P +P PK L      + T    D      P  
Sbjct: 700  TPKETAP--TTPKGTAPTTLKEP-APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 756

Query: 292  SSPLAT--PSPSAP--PSPSAPPSLQ--TLPSP-PATPPSQATTSLGSPTLQ---ATHSF 341
            ++P     P+P+ P  P+P+ P      TL  P P TP   A   L   T +   +T S 
Sbjct: 757  TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 816

Query: 342  LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401
             P+P       P     PA   P   AP +P   PP +   +          +H      
Sbjct: 817  KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 876

Query: 402  SPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPP 451
            +P  S  P  +A  + P  P V  + TP +  P        +         P +  A+P 
Sbjct: 877  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936

Query: 452  MSP--SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS--- 506
            M+   + T        + A   Q+     Q         L+     P     +   +   
Sbjct: 937  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996

Query: 507  ----------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGP 555
                      P      S   TP PQ P    AP        P + P ++ P+  PTP  
Sbjct: 997  IMNKPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRK 1054

Query: 556  DTS 558
             TS
Sbjct: 1055 MTS 1057


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  145 bits (367), Expect = 1e-34
 Identities = 209/797 (26%), Positives = 275/797 (34%), Gaps = 122/797 (15%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK---------- 56
            KA+ G   R+ A +   + +   P  P   P   P AL V       G            
Sbjct: 351  KAQGGQTIRSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPG 410

Query: 57   PLAERAGGIGGATIPESAPRAGPTRTSRP--PASGRGERAPPAKNTSPGPVSSPGRASGT 114
            PL   A  +G A +        P     P  P       +PP + +   P     R S  
Sbjct: 411  PLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPP 470

Query: 115  TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 174
                P       +     +     +  P+ S LS         P P +   +    S  +
Sbjct: 471  PEELPASPLPEALHLSRPLEESPLSPPPEESPLS---------PPPESSPFSPLEESPLS 521

Query: 175  GTEVGLPRPAPSARPRPPTEGPRKS-------VSSASEHSTTEPSPAARRRPSAGGGLQR 227
              E   P PA      PP E    S       +S   E   T P P A R       L  
Sbjct: 522  PPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASR-------LSP 574

Query: 228  PASRSLSSSATPLSSPARSGPSA-RGTPRAPAHPSQPKPKGLQALRPPQ---VTPPRKDA 283
            P   S   S  P  SP    P A R  P     P  P P+      PP+   ++PP +D 
Sbjct: 575  PPEES-PMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPED- 632

Query: 284  APALGPLSSSPLATPSPSAPPSPSAPPSLQTLP---SPPATPPSQATTSLGSPTLQATHS 340
            +P   P   SP++ P   +  SP    S  + P   SP + PP ++ T   SP  +A+  
Sbjct: 633  SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPT---SPPPEASR- 688

Query: 341  FLPSPPLSPLATPP---PQAPP----ALALPPLQAPPSP-PASPPLSPLATPSPQAPNAL 392
              P P  SP + PP   P +PP     ++LP  ++P  P P  P L P +     +P   
Sbjct: 689  LSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPE 748

Query: 393  AVHLLQAPFSPPPSPPVQAP-FSP----------PASPPVSPSATPPSQAP--------P 433
              HL   P  P  SP  + P  SP          P  P +SP A  P  +P        P
Sbjct: 749  EPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSP 808

Query: 434  SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
                P L   P  P   P    +   PQ+  P  +P            P L  PPL   P
Sbjct: 809  QTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSP----RPEESHLSPELEKPPLSPRP 864

Query: 494  SPPASFPGQAPFSPSASLPMSPLATPP--PQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 551
              P   PGQ P      LP+ P   PP  P   P+L  P L  P  PP SP        P
Sbjct: 865  EKPPEEPGQCP--APEELPLFP---PPGEPSLSPLLGEPALSEPGEPPLSPL-------P 912

Query: 552  TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 611
               P +    P L+  L P  P PP  SP  T + P  A         P   +G DS PE
Sbjct: 913  EELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPP-ALSPLGELEYPFGAKG-DSDPE 970

Query: 612  GGAAA-------SPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPL---------PWPPA 655
               AA       SPPP+A             P PP+    +PG+P+         P PP 
Sbjct: 971  SPLAAPILETPISPPPEANCT-------DPEPVPPMILPPSPGSPVGPASPILMEPLPPQ 1023

Query: 656  TGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLG 715
              P     L  + +   P   +P P      PSP +  GK   G    A     +  ++ 
Sbjct: 1024 CSPLLQHSL--VPQNSPPSQCSP-PALPLSVPSPLSPIGK-VVGVSDEAELHEMETEKVS 1079

Query: 716  ELPLGALQASVVQHLLS 732
            E    AL+ S    L S
Sbjct: 1080 EPECPALEPSATSPLPS 1096



 Score =  131 bits (329), Expect = 3e-30
 Identities = 194/724 (26%), Positives = 242/724 (33%), Gaps = 144/724 (19%)

Query: 16   TPAARAPGLLTPRPPGSPRPPP----PVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP 71
            +PA   P  L+P P  SP  PP    P++P                             P
Sbjct: 529  SPALETP--LSPPPEASPLSPPFEESPLSPP----------------------------P 558

Query: 72   ESAPRAGPTRTSR--PPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 129
            E  P + P   SR  PP     E +P +      P+S P  AS    P    +  L    
Sbjct: 559  EELPTSPPPEASRLSPPP----EESPMSPPPEESPMSPPPEASRLFPP--FEESPLSPPP 612

Query: 130  EETVARGKATEAPKRSALSAGARRDTSGP----TPGTPSPAMARRSRAAGTEVGLPRPAP 185
            EE+      +  P+ S LS         P    +P +P P ++R S         P P  
Sbjct: 613  EES----PLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEE 668

Query: 186  SARPRPPTEGPRKSVSSAS------EHSTTEP----SPAARRRPSAGGGLQRPASRSLSS 235
            S    PP E P      AS      E S T P    SPA+     +   L    S  L  
Sbjct: 669  SPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPL 728

Query: 236  SATPLSSPARSGPSARGTPRAPAHPSQPKPKGL--QALRP---PQVTPPRKDAAPA---L 287
               P   P   GP     P  P    +P+   L  QA  P   PQ   P   A P    L
Sbjct: 729  PEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHL 788

Query: 288  GPLSSSPLATPSPSAPP-SPSAP-PSLQTLPSPPATPPSQATTSLG--------SPTLQA 337
             P +  P  +P P     SP    P L  +P  P   P    + L         SP  + 
Sbjct: 789  SPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEE 848

Query: 338  THSF--LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395
            +H    L  PPLSP    PP+ P     P       PP  P LSPL          L   
Sbjct: 849  SHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPL----------LGEP 898

Query: 396  LLQAPFSPPPSP-PVQAPFSPPASPPVSPSATPPSQAPPSL------AAPPL-------- 440
             L  P  PP SP P + P SP   P +SP   PP   PP L      AAPP         
Sbjct: 899  ALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELE 958

Query: 441  --------QVPPSPPASPPMSPSATPPPQAP-------PPLAAPPLQLAKPPPQAPPALA 485
                      P SP A+P +    +PPP+A        PP+  PP   +   P +P  + 
Sbjct: 959  YPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILME 1018

Query: 486  TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP--PVLA----APLLQVPP--- 536
              P Q  P    S   Q       S P  PL+ P P +P   V+     A L ++     
Sbjct: 1019 PLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKV 1078

Query: 537  SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS-----RSPSSTLSGPDLAG 591
            S P  P L+     P P P   +S P      AP P P           ++ L G D  G
Sbjct: 1079 SEPECPALEPSATSPLPSPMGDLSCP------APSPAPALDDFSGLGEDTAPLDGIDAPG 1132

Query: 592  HSSSATSTP----EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG 647
                   TP     EL+G     +    A   P      C   A    P        AP 
Sbjct: 1133 SQPEPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPV 1192

Query: 648  APLP 651
            AP P
Sbjct: 1193 APTP 1196



 Score =  113 bits (283), Expect = 6e-25
 Identities = 219/848 (25%), Positives = 295/848 (34%), Gaps = 125/848 (14%)

Query: 48   GAAGAVGRKPLAERA---GGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGP 104
            G  G  G +   +R    GG+    +P S+P        + P     ER     +  PG 
Sbjct: 1910 GTPGLEGSRTPLQRPFLQGGLPLGNLPSSSPMDSYPGLCQSPFLDSRERGG-FFSPEPGE 1968

Query: 105  VSSPGRASGTTRPG----PLGQ---KGLRISAEETVARGKATEAPKRSALSAGARRDTSG 157
              SP   SG T P     P  +    GL  +        K  E  + S +S     + + 
Sbjct: 1969 PDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINF 2028

Query: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 217
            P      P  + R +     + L R  P+A   P  +  + + ++   +   + + +   
Sbjct: 2029 PNLKQDYPDWSSRCKQI---MKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQIN 2085

Query: 218  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP-----SQPKPKGLQA-- 270
            + +  G + R   R     A  L  P +  P A G+P   A P     S   P GL    
Sbjct: 2086 KQTKVGDIARKTDRP----ALHLRIPPQ--PGALGSPPPAAAPTIFIGSPTTPAGLSTSA 2139

Query: 271  ---LRPPQVTPPRKDA-----------APALGPLSSSP--LATPSPSAPPSPSAPPSLQT 314
               L+PP  + P  D+            PA  P S  P  LA   P  P  P+APP+   
Sbjct: 2140 DGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVP-SQDPFGLAPAYPLEPRFPTAPPTYPP 2198

Query: 315  LPSP---PATPPSQATTSL-GSPTLQATHSFLPSPPLSPLATPPPQAPPAL-ALPPLQAP 369
             PSP   PA PP    +S  G+      H+  P  P    +TP P   P   +L  L  P
Sbjct: 2199 YPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVP 2258

Query: 370  PSPPAS--PPLSPLATPSPQAPNALAVHLLQAPF---SPPPSPPVQAPFSPPAS------ 418
             SP         PL +P P   +  A+ + +      SP   PP       P+S      
Sbjct: 2259 ESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGG 2318

Query: 419  ----------PPVSPSATPPSQAPPSLAAPPLQVPPSPPA--SPPMSPSATPPPQAPPPL 466
                       P++P A+      P L   P + PP+     SPP  P    P     P 
Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPY 2378

Query: 467  AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 526
            A PPL    P PQ P     PP      PP S P   PFS   + P S  ++  P  P  
Sbjct: 2379 AQPPL---TPRPQPP-----PPESCCALPPRSLPSD-PFSRVPASPQSQSSSQSPLTPRP 2429

Query: 527  LAAPLLQVPPSPPASPTLQAP---RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 583
            L+A      PS P +P  Q+P    RPP        S P+     AP   PP  + P   
Sbjct: 2430 LSAEAF--CPS-PVTPRFQSPDPYSRPP--------SRPQSRDPFAPLHKPPRPQPPEVA 2478

Query: 584  LSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAP-PLAF 642
                 LA  S  A   P  L    +G       S  P   + +    A+   P+P    F
Sbjct: 2479 FKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTF 2538

Query: 643  RGAPGAPLPWPPATGPG--SADGLCTIY---ETEG-PESA--TPAPGALDPGPSP-GTSG 693
              A G P   PP   PG     G+ + +    T G P+S   T A G   P  SP G S 
Sbjct: 2539 PQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSS 2598

Query: 694  GKAAAGAGAG---ASSRSPKQARLGELPL---GALQASVVQHLLSRTLLLAAAEGAAGGS 747
            G      G       S  P  A  G LP    GA Q S +      T  +   E    G 
Sbjct: 2599 GSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGI------TSPVEKREDPGTGM 2652

Query: 748  GGGPGGAEGGGVTGGARAALSDAEL------GRWAELLSPLDESRASI--TSVTSFSPDD 799
            G     AE  G      + LS  EL       R  ELL      R ++     T+ +   
Sbjct: 2653 GSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAG 2712

Query: 800  VASPQGDW 807
               P G W
Sbjct: 2713 AVGPPGSW 2720



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 199/788 (25%), Positives = 261/788 (33%), Gaps = 121/788 (15%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE-----R 61
            + K G  AR     A  L  P  PG+   PPP     + +       G    A+      
Sbjct: 2087 QTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPP 2146

Query: 62   AGGIGG--------ATIPESAPRAGPTR-----TSRPPASGRGERAPPAKNTSPGPVSSP 108
            AG + G          +P   P   P++         P   R   APP     P P  +P
Sbjct: 2147 AGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAP 2206

Query: 109  GR---ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSP 165
             +      ++RPG  GQ G       T   G     P         R       P   + 
Sbjct: 2207 AQPPMLGASSRPG-AGQPG----EFHTTPPGTPRHQPSTPDPFLKPR------CPSLDNL 2255

Query: 166  AMARRSRAAGTEVGLP--RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG- 222
            A+       G +   P   P P    R   E  +K    AS  S   P+      PS+G 
Sbjct: 2256 AVPESPGVGGGKASEPLLSPPPFGESRKALE-VKKEELGASSPSYGPPNLGFVDSPSSGT 2314

Query: 223  --GGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP-PQVTPP 279
              GGL+        +  TP +S          +P     P +P P   QAL P P   P 
Sbjct: 2315 HLGGLELKTPDVFKAPLTPRASQVEP-----QSPGLGLRPQEPPP--AQALAPSPPSHPD 2367

Query: 280  RKDAAPALGPLSSSPLATPSPSAPPSPSA---PPSLQTLPSP-----PATPPSQATT-SL 330
                     P +  PL TP P  PP  S    PP  ++LPS      PA+P SQ+++ S 
Sbjct: 2368 IFRPGSYTDPYAQPPL-TPRPQPPPPESCCALPP--RSLPSDPFSRVPASPQSQSSSQSP 2424

Query: 331  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS-PPLSPL-ATPSPQA 388
             +P   +  +F PSP      TP  Q+P      P   PPS P S  P +PL   P PQ 
Sbjct: 2425 LTPRPLSAEAFCPSP-----VTPRFQSP-----DPYSRPPSRPQSRDPFAPLHKPPRPQP 2474

Query: 389  PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP----LQVPP 444
            P    V       +         P + PA P     A  PS  PP+    P        P
Sbjct: 2475 PE---VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTP 2531

Query: 445  SPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA-------PPALATPPLQALPSPPA 497
            SP       P A   P   PP+  P L    PPP          P L  P          
Sbjct: 2532 SPMRF--TFPQAVGEPSLKPPVPQPGL----PPPHGINSHFGPGPTLGKPQSTNYTVATG 2585

Query: 498  SF-PGQAPFSPSA-----SLPMSPLATP---PPQAPPVLAAPLLQVPPSPPASPTLQAPR 548
            +F P  +P  PS+     S  +SPL  P   PP AP   + P L    S  +  T    +
Sbjct: 2586 NFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDG-SLPYLSHGASQRSGITSPVEK 2644

Query: 549  RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 608
            R     P T + G  L  A  PG   P     S T                 ++++    
Sbjct: 2645 R---EDPGTGM-GSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTL 2700

Query: 609  GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY 668
              E   AA+    A  A   P +W   P+ P AF        P+       S  GL    
Sbjct: 2701 RQEKETAAA----AAGAVGPPGSWGAEPSSP-AFEQLSRGQTPFAGTQDKSSLVGL-PPS 2754

Query: 669  ETEGP---ESATPAPGALDPGPSPGTS-----GGKAAAGAGAGASSRSPKQARLGELPLG 720
            +  GP     + P+   L   P P T        +   G       R+P     G LPL 
Sbjct: 2755 KLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYP---GSLPLQ 2811

Query: 721  ALQASVVQ 728
              Q  + Q
Sbjct: 2812 QQQQQLWQ 2819



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 153/656 (23%), Positives = 217/656 (33%), Gaps = 121/656 (18%)

Query: 75   PRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 134
            PRA       P    R +  PPA+  +P P S P      +   P  Q  L    +    
Sbjct: 2333 PRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPP 2392

Query: 135  RGKATEAPKR------SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 188
                   P+       S + A  +  +S  +P TP P  A     +        P P +R
Sbjct: 2393 ESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSR 2452

Query: 189  P--RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 246
            P  RP +  P      A  H    P P     P         A  SL +   P + PA  
Sbjct: 2453 PPSRPQSRDP-----FAPLHKPPRPQP-----PEVAFKAGSLAHTSLGAGGFPAALPA-- 2500

Query: 247  GPSARGTPRAPAH--PSQPKPKGLQAL----RPPQVTPPRKDAAPALGPLSSSPLATPSP 300
            GP+     + P+   P+  +  G  A      P + T P+    P+L P    P   P P
Sbjct: 2501 GPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQP-GLPPP 2559

Query: 301  SAPPSPSAPPSLQTLPSPPATPPSQATTSL---GSPTLQATHSFLPSPPLSPLATP---P 354
                S   P    TL  P +T  + AT +    GSP   ++ S   S  LSPL  P   P
Sbjct: 2560 HGINSHFGPGP--TLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLP 2617

Query: 355  PQAPPALALPPLQAPPSPPA--SPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-- 410
            P AP   +LP L    S  +  + P+     P     ++LA   L     P  S   Q  
Sbjct: 2618 PPAPDG-SLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTE 2676

Query: 411  -------------------------------APFSPPASPPVSPSATPPSQAPPSLA--- 436
                                           A  +    PP S  A P S A   L+   
Sbjct: 2677 LEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQ 2736

Query: 437  ---------APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 487
                     +  + +PPS  + P + P + P             +L++PPP A P+    
Sbjct: 2737 TPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDD----------RLSRPPPPATPSSMDV 2786

Query: 488  PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP--PASPTLQ 545
              + L     +F  +AP+    SLP+        Q     AA  ++   S   P++P  +
Sbjct: 2787 NSRQLVGGSQAFYQRAPY--PGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPE 2844

Query: 546  APRR----------PPTPGPDTSVSGP-----------RLTLALAPGPPPPPSRSPSSTL 584
              R+             PGP   V GP            +   L PG  P P + P    
Sbjct: 2845 LGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRP 2904

Query: 585  SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL-AACHPAAWSRGPAPP 639
                ++         PE LRG           S PP  EL  + HP   ++GP  P
Sbjct: 2905 RFYPVS--EDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPTLP 2958



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 131/542 (24%), Positives = 174/542 (32%), Gaps = 98/542 (18%)

Query: 17   PAARAPGLLTPRPPGSP--RPPPPVTPAALRVLGAAG----AVGRKPLAERAGGIGGATI 70
            P +R P     R P +P  +PP P  P      G+        G  P A  AG  G   +
Sbjct: 2449 PYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAG--EL 2506

Query: 71   PESAPRAGPTRTSRPPASGRGERAP-PAKNTSPGPVSSPGRASGTTRPG----------- 118
                P   P    R P +G     P P + T P  V  P       +PG           
Sbjct: 2507 HAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHF 2566

Query: 119  -PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP---------GTPSPAMA 168
             P    G   S   TVA G    +      S+G+  ++ G +P           P  ++ 
Sbjct: 2567 GPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLP 2626

Query: 169  RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
              S  A    G+  P    +   P  G   S+++A    T +P  +   +       QR 
Sbjct: 2627 YLSHGASQRSGITSPVE--KREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQ 2684

Query: 229  ASRSL----SSSATPLSSPARSGPSARGTPRAP----AHPSQPKPKGLQALRPPQV---- 276
              R L          L     +  +A G    P    A PS P  + L   + P      
Sbjct: 2685 RLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQD 2744

Query: 277  ------TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSL---------------QTL 315
                   PP K + P LGP  S P +    S PP P+ P S+               Q  
Sbjct: 2745 KSSLVGLPPSKLSGPILGP-GSFP-SDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRA 2802

Query: 316  PSPPATPPSQATTSLGSP-----------TLQATHSFLPSPPLSPLATPPPQAPPALALP 364
            P P + P  Q    L               + A     P P L   A   P A  +  LP
Sbjct: 2803 PYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLP 2862

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP-PVQAPFSPPASPPVSP 423
                P   PA P           A      H +Q    P  +P P Q P   P   PVS 
Sbjct: 2863 GPGEPVPGPAGP-----------AQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSE 2911

Query: 424  SATPPSQAPPSL-----AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP 478
               P   AP  L     +  P Q P +PPA P ++ S  P P    P     L+L   PP
Sbjct: 2912 D--PHRLAPEGLRGLAVSGLPPQKPSAPPA-PELNNSLHPTPHTKGPTLPTGLELVNRPP 2968

Query: 479  QA 480
             +
Sbjct: 2969 SS 2970



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 103/387 (26%), Positives = 137/387 (35%), Gaps = 64/387 (16%)

Query: 223  GGLQRPASRSLSSSATPLSSPARSGPSARGT-PRAPA------HPS-------------- 261
            G  Q     ++SS AT   S  + GP A GT P + A       PS              
Sbjct: 4023 GKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQP 4082

Query: 262  QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT 321
            QP+P  LQ L+PP   P ++    +L  L ++   +       S S   S+  L + P+ 
Sbjct: 4083 QPQPSSLQ-LQPPLRLPGQQQQQVSL--LHTAGGGSHGQLGSGSSSEASSVPHLLAQPSV 4139

Query: 322  PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381
                   S+    L      L  P  +     PP+  P L     Q  P     P +  L
Sbjct: 4140 SLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSG--QGLPGVGIMPTVGQL 4197

Query: 382  ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP-PASPPVSPSATPPSQAPPSLAAP-- 438
                 Q    LA +      SP     +QA           +   TPP Q P +  +P  
Sbjct: 4198 RA---QLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQ 4254

Query: 439  -------PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA 491
                    L   P P   P     A P PQ PP L APP  L+  P   P          
Sbjct: 4255 GLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGP---------V 4305

Query: 492  LPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 551
             P+PP S P Q P  PS  LP SP +  P +A         Q+PP+ P +P  Q P   P
Sbjct: 4306 HPTPPPSSP-QEPKRPS-QLP-SPSSQLPTEA---------QLPPTHPGTPKPQGPTLEP 4353

Query: 552  TPG----PDTSVSGPRLTLALAPGPPP 574
             PG        ++    +  L P  PP
Sbjct: 4354 PPGRVSPAAAQLADTLFSKGLGPWDPP 4380



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 150/672 (22%), Positives = 221/672 (32%), Gaps = 135/672 (20%)

Query: 16   TPAARAP--GLLTPRPPGSPRP------PPP--VTPAALRVLGAAGAVGRKP------LA 59
            +P+++ P    L P  PG+P+P      PPP  V+PAA ++     + G  P      LA
Sbjct: 4325 SPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLA 4384

Query: 60   E------------RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSS 107
            E                + G  +PE++  +        P +   +      N    P+ +
Sbjct: 4385 ETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGE--PIGA 4442

Query: 108  PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 167
            PG ++     GP  + G  +   + + R K  +       S G R + +G          
Sbjct: 4443 PGTSNHLLLAGPRSEAGHLLL--QKLLRAKNVQLSTGRG-SEGLRAEINGHID------- 4492

Query: 168  ARRSRAAGTE---VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 224
               S+ AG E    G P     A  R P     K V  AS+      S   + R   G  
Sbjct: 4493 ---SKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLV---SSRKKLRKEDGVR 4546

Query: 225  LQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHP--SQPKPKGLQALRPPQVTPPR 280
                  + L    S  PL+ PA +   +   P     P   Q + +G          P  
Sbjct: 4547 ASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDY 4606

Query: 281  KDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP-------PSQATTSLGSP 333
                     LS+ P  TP  S PP+P  PPS+Q       TP       P  A ++  S 
Sbjct: 4607 YSQLLTKNNLSNPP--TPPSSLPPTP--PPSVQQKMVNGVTPSEELGEHPKDAASARDSE 4662

Query: 334  -TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP----PASPPLSPLATPSPQA 388
              L+ T        L+ L TPP      + +   +   SP    PAS P S L   +P+ 
Sbjct: 4663 RALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRF 4722

Query: 389  PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 448
            P+  +    Q   +  P  P+    S P  P   P      + P  L     +       
Sbjct: 4723 PHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEV 4782

Query: 449  SPPMSPSATPPPQAPPPL-AAPPLQLAKPP-------PQAPPALATPPLQALPSPP---- 496
            S  ++ SA         + A   L   K P       P++P    T P +     P    
Sbjct: 4783 SVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKE 4842

Query: 497  -------------------ASFPG-----------------QAPFSPS--------ASLP 512
                               A  PG                  AP  P+        ++L 
Sbjct: 4843 KGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLD 4902

Query: 513  MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP----RRPPTPGPDTSVSGPRLTLAL 568
            +  L+ PPP+ P    +PL   P SPP  P ++ P      PP P P    S P      
Sbjct: 4903 VRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPE----- 4957

Query: 569  APGPPPPPSRSP 580
                P P +R P
Sbjct: 4958 -SARPKPRARPP 4968



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 139/564 (24%), Positives = 189/564 (33%), Gaps = 120/564 (21%)

Query: 117  PGPLGQKGLRISAEETVA----RGKATEAPKR---SALSAGARRDTSGPTPGTPSPAMAR 169
            PG LG   L    E+         +ATE P       L+ G   ++    PG   P+++ 
Sbjct: 4012 PGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSG 4071

Query: 170  RSRAAGTEVGLPRPAPSA-RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
             S+    +   P+P PS+ + +PP   P +     S   T            AGGG    
Sbjct: 4072 DSQLLLVQPQ-PQPQPSSLQLQPPLRLPGQQQQQVSLLHT------------AGGGSHGQ 4118

Query: 229  ASRSLSSSATP----LSSPARSGPSARGTPR----APAHPSQPKP-KGLQALRPPQVTP- 278
                 SS A+     L+ P+ S     G+       P  P   +P +     +PP+  P 
Sbjct: 4119 LGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPV 4178

Query: 279  -------PRKDAAPALGPLSSS---PLATPSPSAPPSPSAPPSLQTL------------- 315
                   P     P +G L +     LA        SP     LQ L             
Sbjct: 4179 LQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVR 4238

Query: 316  PSPPATPPSQATTSL-GSPTLQATHSFLPSPPLSPL----ATPPPQAPPALALPPLQAPP 370
             +PP   P   T+ L G    Q      P P   PL    A P PQ PP L        P
Sbjct: 4239 QTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRL--------P 4290

Query: 371  SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 430
            +PP +    P+  P         VH      +PPPS P +     P  P   PS  P SQ
Sbjct: 4291 APPGALSTGPVLGP---------VHP-----TPPPSSPQE-----PKRPSQLPS--PSSQ 4329

Query: 431  APPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPL 489
             P        Q+PP+ P +P P  P+  PPP    P AA          Q    L +  L
Sbjct: 4330 LPTE-----AQLPPTHPGTPKPQGPTLEPPPGRVSPAAA----------QLADTLFSKGL 4374

Query: 490  QALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR 549
                 P      Q P   S+ +P           P      + Q P   P +   Q+ +R
Sbjct: 4375 GPWDPPDNLAETQKP-EQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKR 4433

Query: 550  ----PPTPGPDTS----VSGPR------LTLALAPGPPPPPSRSPSSTLSGPDLAGH-SS 594
                 P   P TS    ++GPR      L   L        S    S     ++ GH  S
Sbjct: 4434 EANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDS 4493

Query: 595  SATSTPEELRGYDSGPEGGAAASP 618
                  ++L+G  S  E  AA  P
Sbjct: 4494 KLAGLEQKLQGTPSNKEDAAARKP 4517



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 73/311 (23%), Positives = 111/311 (35%), Gaps = 37/311 (11%)

Query: 101  SPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE---APKRSALSAGARRDTSG 157
            S G + S   +  ++ P  L Q  + +  +     G  T+    P++  L    + +T G
Sbjct: 4115 SHGQLGSGSSSEASSVPHLLAQPSVSLGDQP----GSMTQNLLGPQQPMLERPMQNNT-G 4169

Query: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP---TEGPRKSVSSASEHSTTEPSPA 214
            P P  P P +       G  VG+       R +      + P+    S  +    +    
Sbjct: 4170 PQPPKPGPVLQSGQGLPG--VGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLM 4227

Query: 215  ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ-----PKPKGLQ 269
             R+   +    Q P  +   +  +PL       P   G P     P Q     P+P+G  
Sbjct: 4228 QRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQG-- 4285

Query: 270  ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTS 329
                    PPR  A P  G LS+ P+       P  P+ PPS    P  P+  PS ++  
Sbjct: 4286 --------PPRLPAPP--GALSTGPVL-----GPVHPTPPPSSPQEPKRPSQLPSPSSQL 4330

Query: 330  LGSPTLQATHSFLPSPPLSPLATPPPQAPPALA--LPPLQAPPSPPASPPLSPLATPSPQ 387
                 L  TH   P P    L  PP +  PA A     L +    P  PP +   T  P+
Sbjct: 4331 PTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPE 4390

Query: 388  APNALAVHLLQ 398
              + +  HL Q
Sbjct: 4391 QSSLVPGHLDQ 4401



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 109/429 (25%), Positives = 144/429 (33%), Gaps = 74/429 (17%)

Query: 303  PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA----- 357
            P  P+ P  LQ   SP A  P+   T     T+         P +S  AT  P       
Sbjct: 3999 PGMPAKP--LQHFSSPGALGPTLLLTGKEQNTVD--------PAVSSEATEGPSTHQGGP 4048

Query: 358  ------PPALALPPLQAPPSPPASPPLSPLATPSPQA-PNALAVHLLQAPFSPPPSPPVQ 410
                  P ++A  P +  PS      L  L  P PQ  P++L    LQ P   P     Q
Sbjct: 4049 LAIGTTPESMATEPGEVKPSLSGDSQLL-LVQPQPQPQPSSLQ---LQPPLRLPGQQQQQ 4104

Query: 411  APFSPPASPPV-----SPSATPPSQAPPSLAAPPLQVPPSPPASP-----PMSPSATPPP 460
                  A         S S++  S  P  LA P + +   P +       P  P    P 
Sbjct: 4105 VSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPM 4164

Query: 461  Q----APPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPMSP 515
            Q      PP   P LQ  +  P          L+A L    A  P     SP     +  
Sbjct: 4165 QNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQA 4224

Query: 516  LA-------------TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP 562
            L              TPP Q P    +PL  +    P             PGP T   GP
Sbjct: 4225 LLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF--------PGPQT---GP 4273

Query: 563  RLTLALAPGPPPPPS--RSPSSTLSGPDLAG-HSSSATSTPEELRGYDSGPEGGAAASPP 619
               L   P P  PP     P +  +GP L   H +   S+P+E +     P    ++  P
Sbjct: 4274 LQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS--PSSQLP 4331

Query: 620  PDAELAACHPAAWS-RGPA---PPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPES 675
             +A+L   HP     +GP    PP     A         + G G  D    + ET+ PE 
Sbjct: 4332 TEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQ 4391

Query: 676  ATPAPGALD 684
            ++  PG LD
Sbjct: 4392 SSLVPGHLD 4400



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 35/96 (36%), Positives = 43/96 (44%), Gaps = 17/96 (17%)

Query: 383  TPSPQAPNA---------LAVHLLQAPF----SPPPSPPVQAPFSPPASP----PVSPSA 425
            +P+P+ P           L V  L AP     SPPPSP   +P SPP  P    P  P A
Sbjct: 4883 SPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLA 4942

Query: 426  TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 461
             PP  +P  LA+ P    P P A PP     + PP+
Sbjct: 4943 EPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPR 4978



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 168/743 (22%), Positives = 227/743 (30%), Gaps = 139/743 (18%)

Query: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86
            PRP G PR P P  P AL      G V   P             P S+P+  P R S+ P
Sbjct: 4281 PRPQGPPRLPAP--PGALSTGPVLGPVHPTP-------------PPSSPQE-PKRPSQLP 4324

Query: 87   ASGRG----ERAPPAKNTSPGPVSS-----PGRASGTTRP--GPLGQKGLRI-SAEETVA 134
            +         + PP    +P P        PGR S         L  KGL      + +A
Sbjct: 4325 SPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLA 4384

Query: 135  RGKATEAPKRSALSAGARRDTSGPT-PGTPSPAMARRSR----AAGTEV------GLPRP 183
                T+ P++S+L  G     +G   P     ++ +  R    A G +       G P  
Sbjct: 4385 E---TQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIG 4441

Query: 184  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
            AP         GPR                          GL+   +  + S    L   
Sbjct: 4442 APGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQK 4501

Query: 244  ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK-------DAAPAL-----GPLS 291
             +  PS +    A   P  PKPK +Q      V+  +K        A+ AL       LS
Sbjct: 4502 LQGTPSNK-EDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELS 4560

Query: 292  SSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 351
              PL  P+ +A  S  AP         P    SQ   + GS                 L 
Sbjct: 4561 LLPLTEPAITANFSLFAPFG----SGCPVNGQSQLRGAFGS---------------GALP 4601

Query: 352  TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNA------LAVHLLQAPFSPPP 405
            T P      L    L  PP+PP+S P +P  +   +  N       L  H   A  +   
Sbjct: 4602 TGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDS 4661

Query: 406  SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP----PASPPMSPSATPPPQ 461
               ++      +   ++   TPP      +     +   SP    PAS P S      P+
Sbjct: 4662 ERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPR 4721

Query: 462  AP---------PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP----- 507
             P            A  P+    P    P    T P  AL       PG+ P +      
Sbjct: 4722 FPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGAL---GLEVPGKLPVTTWEKGK 4778

Query: 508  ----SASLPMSPLATPPPQAPPVLAAPLLQV----------PPSPPASPTLQAPRRPPTP 553
                S  L +S  A        V  A LL +          P SP  + T   P++    
Sbjct: 4779 GSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGT--EPKKGEAE 4836

Query: 554  GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH--------SSSATSTPEELRG 605
            GP     G       +P   P   +   + L G  L             S    P     
Sbjct: 4837 GPGGKEKGLE---GKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHS 4893

Query: 606  YD---SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSAD 662
            Y    S  +    ++PPP+       P A S    P       P  PL  PP   P    
Sbjct: 4894 YTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSP---- 4949

Query: 663  GLCTIYETEGPESATPAPGALDP 685
                +     PESA P P A  P
Sbjct: 4950 ----LPLASSPESARPKPRARPP 4968



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 105/458 (22%), Positives = 139/458 (30%), Gaps = 117/458 (25%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVT--PAALRVLGAAGAV--GRKPLAERAGGIG 66
            G  +  P    PGL  P    S   P P    P +     A G       PL   +G  G
Sbjct: 2543 GEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTG 2602

Query: 67   GA----------TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRAS---- 112
             +           +P  AP       S   +   G  +P  K   PG       A+    
Sbjct: 2603 ESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELP 2662

Query: 113  GTTRPGPLG------------QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP 160
            GT  PG  G            Q+   +   + + R    +  + +A +AGA         
Sbjct: 2663 GTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGA 2722

Query: 161  GTPSPAMARRSRA----AGTE-----VGLP---------------------RPAPSARPR 190
               SPA  + SR     AGT+     VGLP                     RP P A P 
Sbjct: 2723 EPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPS 2782

Query: 191  PPTEGPRKSVSSASEHSTTEPSPAA------------RRRPSAGGGLQRPASRSLSSSAT 238
                  R+ V  +       P P +            +++ +A   ++   S    S+  
Sbjct: 2783 SMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPG 2842

Query: 239  P-LSSPARSGPSARGTPRAPAHPSQPKP----------------KGL-------QALRPP 274
            P L   A   P A  + R P  P +P P                KGL           PP
Sbjct: 2843 PELGRQALGSPLAGISTRLPG-PGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPP 2901

Query: 275  Q-------VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327
            Q          P + A   L  L+ S L    PSAPP+P    SL   P           
Sbjct: 2902 QRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTK-------- 2953

Query: 328  TSLGSPTLQATHSFLPSPPLS-PLATPPPQAPPALALP 364
                 PTL      +  PP S  L  P P A  A  LP
Sbjct: 2954 ----GPTLPTGLELVNRPPSSTELGRPNPLALEAGKLP 2987



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 73/298 (24%), Positives = 96/298 (32%), Gaps = 51/298 (17%)

Query: 419  PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP-LQLAKPP 477
            P VS  AT   + P +    PL +  +P +       AT P +  P L+    L L +P 
Sbjct: 4031 PAVSSEAT---EGPSTHQGGPLAIGTTPESM------ATEPGEVKPSLSGDSQLLLVQPQ 4081

Query: 478  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM---------SPLATPPPQAPPVLA 528
            PQ  P+     LQ    PP   PGQ     S              S  ++     P +LA
Sbjct: 4082 PQPQPS----SLQL--QPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLA 4135

Query: 529  APLLQVPPSP---------PASPTLQAPRR------PPTPGPDTSVSGPRLTLALAPGPP 573
             P + +   P         P  P L+ P +      PP PGP          + + P   
Sbjct: 4136 QPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVG 4195

Query: 574  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA-CHPAAW 632
               ++        P L   S       + L       +  A    PP  E      P   
Sbjct: 4196 QLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQG 4255

Query: 633  SRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 690
              G  P L   G PG      P TGP    G       +GP      PGAL  GP  G
Sbjct: 4256 LLGCQPQLG--GFPG------PQTGPLQELGAGP--RPQGPPRLPAPPGALSTGPVLG 4303



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 62/274 (22%), Positives = 88/274 (32%), Gaps = 50/274 (18%)

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRP-------------GPLGQKGLRISAEET 132
            P S  GE AP   +   G      RA     P              P G  GL +  +  
Sbjct: 4711 PESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLP 4770

Query: 133  VA---RGKATEAPKRSALSAGARRDTSG------------------------PTPGTPSP 165
            V    +GK +E      +SA A ++ +G                        P      P
Sbjct: 4771 VTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEP 4830

Query: 166  AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL 225
                     G E GL   +P   P    +          +      S   +  P+     
Sbjct: 4831 KKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPT 4890

Query: 226  QRPASRSLSS-SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 284
            Q   + ++S+     LS+P    PS   +P AP+  S P    ++    P   PP     
Sbjct: 4891 QHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPP----V 4946

Query: 285  PALGPLSSSP-LATPSPSAPP----SPSAPPSLQ 313
            P+  PL+SSP  A P P A P      S PP L+
Sbjct: 4947 PSPLPLASSPESARPKPRARPPEEGEDSRPPRLK 4980



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 8/83 (9%)

Query: 282  DAAPALGPLSSSPLATPSPSAPPSPSAPPS--LQTLPSPP-ATPPSQATTSLGSPTLQAT 338
            D      P    P   PSP AP SP++PP+  L  LP+ P A PP  +   L S    + 
Sbjct: 4902 DVRQLSAPPPEEPSPPPSPLAP-SPASPPTEPLVELPTEPLAEPPVPSPLPLAS----SP 4956

Query: 339  HSFLPSPPLSPLATPPPQAPPAL 361
             S  P P   P        PP L
Sbjct: 4957 ESARPKPRARPPEEGEDSRPPRL 4979



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 9/80 (11%)

Query: 21   APGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER--AGGIGGATIPESAPRAG 78
            AP    P PP SP  P P +P    ++     +  +PLAE      +  A+ PES   A 
Sbjct: 4908 APPPEEPSPPPSPLAPSPASPPTEPLV----ELPTEPLAEPPVPSPLPLASSPES---AR 4960

Query: 79   PTRTSRPPASGRGERAPPAK 98
            P   +RPP  G   R P  K
Sbjct: 4961 PKPRARPPEEGEDSRPPRLK 4980


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score =  142 bits (359), Expect = 1e-33
 Identities = 195/733 (26%), Positives = 277/733 (37%), Gaps = 97/733 (13%)

Query: 34  RPPPPVTPAALRVLGAAGAVG-RKPLAERAGGIGGAT-IPESAPRAGPTRTSRPPASGRG 91
           R PP   P +L V G  G  G  +PL+        AT + +  P A    T    A GR 
Sbjct: 313 RAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRC 372

Query: 92  ERAPPAK----NTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 147
                ++    + SP  V S GR S  + P P  +     S+ +T +  ++++    + +
Sbjct: 373 SLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPS--SSSDTWSHSQSSD----TIV 426

Query: 148 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 207
           S G+   + G + G P  + A  S     + G  R +PS            S+ S+ + S
Sbjct: 427 SDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTL-SIRSSGQLS 485

Query: 208 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG 267
               S    +RP        P  R+ S     L+ P   GP   G P  P    QP    
Sbjct: 486 GRSVSLRKLKRPPP------PPRRTHSLHQRGLAVP--DGPL--GLPPKPERKQQP---- 531

Query: 268 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327
            Q  RPP  T    + A A  P   +P  +  P   P  S  P     P    +P S  +
Sbjct: 532 -QLPRPP--TTGGSEGAGA-APCPPNPANSWVPGLSPGGSRRPPRS--PERTLSPSSGYS 585

Query: 328 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ 387
           +  G+PTL      L  PP SP    PP+     +L   ++P +  +S   S  ++ S  
Sbjct: 586 SQSGTPTLPPKG--LAGPPASPGKAQPPKPERVTSL---RSPGASVSSSLTSLCSSSSDP 640

Query: 388 APNALAVHLLQAP----FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443
           AP+  +   +  P    F  PP P V APFSPP S P SP+   P+ A P++   P+   
Sbjct: 641 APSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTT 700

Query: 444 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQA 503
            + P SPP   +   P Q  P ++        PPP  PP+   PP      PP   P   
Sbjct: 701 DASPQSPPTPQTTLTPLQESPVISKD----QSPPPSPPPSYHPPP------PPTKKPEVV 750

Query: 504 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 563
             +PSA    S  A  P Q P          PP PP +P  Q       P P+ +     
Sbjct: 751 VEAPSA----SETAEEPLQDP--------NWPPPPPPAPEEQDLSMADFPPPEEAF---- 794

Query: 564 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 623
              ++A   P  PS SP   +S P  A  SSSAT+   +  G         +  PPP   
Sbjct: 795 --FSVASPEPAGPSGSP-ELVSSP--AASSSSATALQIQPPG---------SPDPPP--- 837

Query: 624 LAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683
                       P  P     APG     P     G + G     E  G    TP+   +
Sbjct: 838 -----------APPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQM 886

Query: 684 DPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL-PLGALQASVVQHLLSRTLLLAAAEG 742
               S G  GG      G  A  +  ++A  G   P+ A  + +   +  +   LAA+EG
Sbjct: 887 VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEG 946

Query: 743 AAGGSGGGPGGAE 755
            +     GP  AE
Sbjct: 947 LSSAQPNGPPEAE 959



 Score =  106 bits (264), Expect = 1e-22
 Identities = 165/615 (26%), Positives = 218/615 (35%), Gaps = 105/615 (17%)

Query: 13   AARTPAARAPGLLTPRPPGS---PRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT 69
            A+ T + R+ G L+ R        RPPPP  P     L   G      LA   G +G   
Sbjct: 472  ASDTLSIRSSGQLSGRSVSLRKLKRPPPP--PRRTHSLHQRG------LAVPDGPLG--- 520

Query: 70   IPESAPRAGPTRTSRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124
            +P    R    +  RPP +G  E A     PP    S  P  SPG   G+ RP    ++ 
Sbjct: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPG---GSRRPPRSPERT 577

Query: 125  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR-- 182
            L  S+  +   G  T  PK  A   G         P  P    + RS  A     L    
Sbjct: 578  LSPSSGYSSQSGTPTLPPKGLA---GPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLC 634

Query: 183  -----PAPSARPRPPTEGPRKSVSSASEHSTT----EPSPAARRRPSAGGGLQRPASRSL 233
                 PAPS R  P    P         H        P P+  R P+       PA+ +L
Sbjct: 635  SSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN-------PAAPAL 687

Query: 234  SSSAT---PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 290
            ++ A    P+S+   S P +  TP+    P Q  P   +   PP   PP     P   P 
Sbjct: 688  AAPAVVPGPVSTTDAS-PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPP--PT 744

Query: 291  SSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGS--PTLQATHSFLPSPPLS 348
                +   +PSA  +   P      P PP   P +   S+    P  +A  S     P  
Sbjct: 745  KKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAG 804

Query: 349  PLATPPPQAPPALALPPLQA----PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS-- 402
            P  +P   + PA +     A    PP  P  PP  P   P+  AP  +A    + P    
Sbjct: 805  PSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCS 864

Query: 403  ---PPPSPPVQAPFSPPASPPV-------SPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452
                PP   V AP   P+   +       +P   P     PS    PL+   S  ASP  
Sbjct: 865  KGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVP 924

Query: 453  SPS----ATPPPQAPPPLAAPPLQLAKP--PPQAPPALATPPLQALPSPPASF------- 499
            +PS    A    +A    A+  L  A+P  PP+A P    PP    P+  ASF       
Sbjct: 925  APSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPR---PPQS--PASTASFIFSKGSR 979

Query: 500  --PGQAPFSPSASLPM---------SPLATPPPQAP--------PVLAAPLLQVPP-SPP 539
                + P SP     +         S     PPQAP        PV   P + VPP + P
Sbjct: 980  KLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASP 1039

Query: 540  ASPTLQAPRRPPTPG 554
            + P  +    PPT G
Sbjct: 1040 SYPRAEPLTAPPTNG 1054



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 128/513 (24%), Positives = 172/513 (33%), Gaps = 110/513 (21%)

Query: 16   TPAARAPGLL-TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74
            TP     GL   P  PG  +PP P    +LR  GA+ +     L   +        P  +
Sbjct: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD------PAPS 643

Query: 75   PRAGPT-------RTSRPPASGRGE--RAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 125
             R+GP        R   PP          PP+K  SP P ++P  A+    PGP+     
Sbjct: 644  DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP-AAPALAAPAVVPGPVS---- 698

Query: 126  RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 185
                         T+A  +S            PTP T    +      +  +   P P P
Sbjct: 699  ------------TTDASPQSP-----------PTPQTTLTPLQESPVISKDQSPPPSPPP 735

Query: 186  SARPRPP-TEGPRKSVSSASEHSTTE-----------PSPAARRRPSAGGGLQRPASRSL 233
            S  P PP T+ P   V + S   T E           P PA   +  +      P     
Sbjct: 736  SYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFF 795

Query: 234  SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
            S     ++SP  +GPS  G+P   + P+            P  +P    A PA  P SS+
Sbjct: 796  S-----VASPEPAGPS--GSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSA 848

Query: 294  P-----LATPSPSAPPSPSAPPSLQTLPSPPATPPSQATT---SLGSPTLQATHSFLPSP 345
            P     L    P        PP  + + +P  TP         S+G+P    T +  PS 
Sbjct: 849  PGHVAKLPQKEPVGCSKGGGPPR-EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSA 907

Query: 346  PLSPL-------ATPPPQ-----------------APPALALPPLQAPPSPPASPPLSPL 381
            P  PL       A+P P                  A   L+      PP     PP SP 
Sbjct: 908  PQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPA 967

Query: 382  ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF----------SPPASPPVSPSATPPSQA 431
            +T S           L+ P SP     +Q              PP +P  SP A PP   
Sbjct: 968  STASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVAR 1027

Query: 432  PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464
             PS+  P    PP+ P+ P   P   PP    P
Sbjct: 1028 KPSVGVP----PPASPSYPRAEPLTAPPTNGLP 1056


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  142 bits (358), Expect = 1e-33
 Identities = 175/645 (27%), Positives = 234/645 (36%), Gaps = 83/645 (12%)

Query: 88   SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSA 146
            SG    + P   ++    S  G  S T   G +  + +  S   E   RG   E   ++ 
Sbjct: 536  SGSSSSSIPESQSNHSNQSDSG-VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKAR 594

Query: 147  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS-VSSASE 205
            + +  R  TS   P +P P +     A+     LP P P   P PP   P    + S S 
Sbjct: 595  MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSA 654

Query: 206  HSTTEPSPA---------ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256
             S    +P           +      G L +P +  +  S +    P    P     P  
Sbjct: 655  PSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSV--KPQILVPPNGVVPPP 712

Query: 257  PAHPSQPKPKGLQA-LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL 315
            P  P  P P    A L+P    P     +    PL    +   +  APP+P  PP +   
Sbjct: 713  PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPA- 771

Query: 316  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 375
            P PP  PP    T + +PT  +T +  P    +   TP P  PPA   P   A   PP S
Sbjct: 772  PLPPQAPPKPLVT-IPAPT--STKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPP-S 827

Query: 376  PPLSPLATPSPQAP--NALAVHLLQAPFSPPPS--PPVQAPFSPPASPPVSPS------- 424
            PP  P+  P P  P   +       +P SP PS    + + F PP +PP   S       
Sbjct: 828  PPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP 887

Query: 425  ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA----PPPLAAPPLQLAKPPPQA 480
            A    Q+PP++ A P   P S P   P  P   PPP++    PPP   PP  +  PPP  
Sbjct: 888  ANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP---PPSPVPAPPPPP 942

Query: 481  PP-ALATPPLQALP--------SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 531
            PP A  TP     P        SP    P   P   S+    S    P P+ P V +   
Sbjct: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVS 1002

Query: 532  LQVPPSPPASP---TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD 588
               PP+   SP   TL  P  PP PG   ++SG  L   L  G           +   P 
Sbjct: 1003 KFTPPAESGSPSKETLPPPAAPPKPG-KLNLSGVNLPGVLQQG---------CVSAKAPV 1052

Query: 589  LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH---PAAWSRGPAPPLAFRGA 645
            L+G         + +  + S P       PPP+ EL       PA +S   +P +A    
Sbjct: 1053 LSGRGK------DSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV--V 1104

Query: 646  PGAPLPW--------PPATGPGSADG--LCTIYETEGPESATPAP 680
               P  W        PP T P   D   L     +E P  AT  P
Sbjct: 1105 NPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP 1149



 Score =  120 bits (302), Expect = 4e-27
 Identities = 137/501 (27%), Positives = 170/501 (33%), Gaps = 91/501 (18%)

Query: 241 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ-------VTPPRKDAAPALGPLSSS 293
           SS  +SG S+   P + ++ S     G+   +P         V+    +A      L  S
Sbjct: 531 SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES 590

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353
             A       P  S  P L   P P    P  A+               PSPPL P   P
Sbjct: 591 SKARMESMNRPYTSLVPPLS--PQPKIVTPYTASQ--------------PSPPLPP---P 631

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 413
           PP  PP    PP   PP PP  PPL   + PS  +   + V           S    A F
Sbjct: 632 PPPPPP----PP---PPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALF 684

Query: 414 SPPASPPV--SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP--PPLAAP 469
            PP +PPV  S S  P    PP+   PP   PP PP          P P AP  P  +AP
Sbjct: 685 KPP-TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAP 743

Query: 470 P-----------LQLAKPPPQAPPALATP-PLQALPSPPASFPGQAPFSPSASLPMSPLA 517
           P            Q+A P P  PP +  P P QA P P  + P  AP S     P+   A
Sbjct: 744 PPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIP--APTSTKTVAPVVTQA 801

Query: 518 TPPPQAPPVLAAPLLQVPPSP--PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575
            PP   PPV        PP+   PA P    P  PPTP                P P PP
Sbjct: 802 APPTPTPPV--------PPAKKQPAFPASYIPPSPPTP----------------PVPVPP 837

Query: 576 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRG 635
           P+     +          S   S  +++      P        PP  E     P   +  
Sbjct: 838 PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP------TPPAMESQPLKPVPANVA 891

Query: 636 PAPPLAFRGAP-----GAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 690
           P  P A +  P       P+P P    P     L        P  A P P      P+P 
Sbjct: 892 PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPD 951

Query: 691 TSG--GKAAAGAGAGASSRSP 709
            SG  GK  +   +    + P
Sbjct: 952 KSGSPGKKTSKTSSPGGKKPP 972



 Score =  120 bits (300), Expect = 7e-27
 Identities = 164/671 (24%), Positives = 230/671 (34%), Gaps = 113/671 (16%)

Query: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK-------PLAERAGGIG 66
            A  P+   P    P PP  P PPPP  P   +   +AG+              + A    
Sbjct: 621  ASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS 680

Query: 67   GATIPESAPRAGPTRTSRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 122
            GA      P    +++ +P    P +G     PP     P P  +PG A    +P P   
Sbjct: 681  GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPP-----PPPPPTPGSAMAQLKPAPCAP 735

Query: 123  KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182
               + SA            P             + PTP  P P  A     A  +  +  
Sbjct: 736  SLPQFSA----------PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTI 785

Query: 183  PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242
            PAP++     T+     V+ A+  + T P P A+++P+       P+  +      P + 
Sbjct: 786  PAPTS-----TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL 840

Query: 243  PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302
            P +    A+  P +P  P     K + +  PP  TPP  ++ P L P+ ++      P+ 
Sbjct: 841  PKQQSFCAK-PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP-LKPVPANVAPQSPPAV 898

Query: 303  PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP-AL 361
               P   PS   +PSP   PP   ++ +            P PP SP+  PPP  PP A 
Sbjct: 899  KAKPKWQPSSIPVPSPDFPPPPPESSLV-----------FPPPPPSPVPAPPPPPPPTAS 947

Query: 362  ALPPLQAPPSPPASPPLSPLATPSPQAP--NALAVHLLQAPFSPPPSPPVQ---APFSPP 416
              P     P    S   SP     P  P  N+       A    P  P V    + F+PP
Sbjct: 948  PTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPP 1007

Query: 417  A-SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP------PQAPPPLAAP 469
            A S   S    PP  APP      L     P        SA  P        +     +P
Sbjct: 1008 AESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSP 1067

Query: 470  PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL---------PMSPLATPP 520
            P     PPP     L  PP++     PA F G    SP  ++          MS    PP
Sbjct: 1068 PSDSDFPPPPPETELPLPPIEI----PAVFSGNT--SPKVAVVNPQPQQWSKMSVKKAPP 1121

Query: 521  PQAP----------------PVLAAPLLQVPPSPPASPTLQ--------------APRRP 550
            P  P                P +A  + QVP SP +S ++Q              +  R 
Sbjct: 1122 PTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRH 1181

Query: 551  PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGP 610
             +     S + P  T+     PPPPP       LS    AG+  S       + GY +  
Sbjct: 1182 GSLSSRMSRAEPTATMDDMALPPPPP-----ELLSDQQKAGYGGS------HISGYATLR 1230

Query: 611  EGGAAASPPPD 621
             G   A P  D
Sbjct: 1231 RGPPPAPPKRD 1241


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score =  140 bits (353), Expect = 5e-33
 Identities = 187/716 (26%), Positives = 259/716 (36%), Gaps = 126/716 (17%)

Query: 15   RTPAARAPGLLTPRPPGSPRPPPPV----------------TPAALRVL--GAAGAVGRK 56
            + P A   G   P+PPG+   P  V                 P   + L  GA      +
Sbjct: 425  KQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQ 484

Query: 57   PLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 116
             L+     +GG  +  +AP  G    + P  + +    P     S GPV +P        
Sbjct: 485  QLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGP----LSLGPVLAPHS------ 534

Query: 117  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 176
                G     I +   +  G+        +L+AG+    S P P  P+     +      
Sbjct: 535  ----GAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPP 590

Query: 177  EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA--GGGLQRPASRSLS 234
                    P    +P T  P  +   A+   T +P+P A    S     GLQ+P ++   
Sbjct: 591  SAVAMLNTPDGLVQPAT--PAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPP 648

Query: 235  SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP---RKDAAPALGPLS 291
             + TP +    + P    TP+ P+      P+ +   +PP  TP     +D+     P  
Sbjct: 649  QAPTPQA----AAPPQATTPQ-PSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQE 703

Query: 292  SSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 351
             S    P  +  P  S P S+     PPA  P+ AT     P  +       +P      
Sbjct: 704  RS--QQPLSAEGPHLSVPASVIVSAPPPAQDPAPAT-----PVAKGAGLGPQAPDSQASP 756

Query: 352  TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 411
             P PQ P   A  PL+ P   P+S P  P   P   +P+  + H  + P  PP  P  Q+
Sbjct: 757  APAPQIP---AAAPLKGP--GPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRP--QS 809

Query: 412  PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 471
               PP+ PP+ P   PP QAPP+L  P + V  +    PP  P++ P P AP P   PPL
Sbjct: 810  VSRPPSEPPLHP--CPPPQAPPTL--PGIFVIQNQLGVPP--PASNPAPTAPGP-PQPPL 862

Query: 472  QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 531
            +    PP+        PL   P  P S    A  S S +    P  TP            
Sbjct: 863  RPQSQPPEG-------PLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQ-------- 907

Query: 532  LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRS--------- 579
            LQ PPS       Q P + PTP P         TL L P    PPPPP R+         
Sbjct: 908  LQFPPS-------QGPHKSPTPPP---------TLHLVPEPAAPPPPPPRTFQMVTTPFP 951

Query: 580  ----PSSTL-------SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 628
                P + L       SG  L   +  A + P+       GP    AAS     +  +  
Sbjct: 952  ALPQPKALLERFHQVPSGIILQNKAGGAPAAPQ--TSTSLGPLTSPAASVLVSGQAPSGT 1009

Query: 629  PAAWSRGPAP-PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683
            P A S  PAP P+A  G P    P  PA     A  L T+   +   S    P  L
Sbjct: 1010 PTAPSHAPAPAPMAATGLP----PLLPAENKAFASNLPTLNVAKAASSGPGKPSGL 1061



 Score =  139 bits (349), Expect = 1e-32
 Identities = 215/805 (26%), Positives = 301/805 (37%), Gaps = 162/805 (20%)

Query: 20   RAPGLLTPRPPGSPRP------PPPVTPAA--LRVLGAAGAVGRKPLAER-----AGGIG 66
            R P  + P+P G   P      P P  PA   L + G  GA+ ++P A +     A G  
Sbjct: 346  RTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKA 405

Query: 67   GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 126
            G  +  S   A       P       + PPA  T   P   PG  S       L Q    
Sbjct: 406  GQNVVLSGFPA-------PALQANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSI 458

Query: 127  ISAEETVARGK---------ATEAPKR-SALSA---GARRDTSGPTPG---TPSPAMARR 170
            +   + +  G+         A + P++ SAL A   G     + P  G     +P +  +
Sbjct: 459  VIPAQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQ 518

Query: 171  SRAAGTEVGLPRPAP----------SARP----RPPTEGPRKSVSSASEHSTTEPSPAAR 216
            + A    +G P  AP          SA P    +P       S+++ S  + ++P+PA  
Sbjct: 519  NLAGPLSLG-PVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGP 577

Query: 217  RRPSAGGGLQRPASR--------SLSSSATPLSSPARSGP--SARGTPRAPAHPSQPKPK 266
               +   G+  P S          L   ATP ++   + P  + +  P+AP   S P P 
Sbjct: 578  AATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPL 637

Query: 267  GLQ---ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPP 323
            GLQ   A +PPQ   P+  A P           TP PS  P  ++ P    L  PP+  P
Sbjct: 638  GLQQPQAQQPPQAPTPQAAAPPQA--------TTPQPS--PGLASSPEKIVLGQPPSATP 687

Query: 324  SQATTSLGSPTLQATHSFLPSP----PLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 379
            +   T        +   FLP      PLS  A  P  + PA  +  + APP      P +
Sbjct: 688  TAILTQ------DSLQMFLPQERSQQPLS--AEGPHLSVPASVI--VSAPPPAQDPAPAT 737

Query: 380  PLATPS---PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436
            P+A  +   PQAP++      QA  +P P  P  AP   P  P  SPS   P QAP    
Sbjct: 738  PVAKGAGLGPQAPDS------QASPAPAPQIPAAAPLKGPG-PSSSPSL--PHQAP---- 784

Query: 437  APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496
               L   P  P     SP  T PP  PP   + P  +++PP +       PPL   P P 
Sbjct: 785  ---LGDSPHLP-----SPHPTRPPSRPP---SRPQSVSRPPSE-------PPLHPCPPPQ 826

Query: 497  ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 556
            A      P  P   +  + L  PPP + P   AP    PP PP  P  Q P  P      
Sbjct: 827  A-----PPTLPGIFVIQNQLGVPPPASNP---APTAPGPPQPPLRPQSQPPEGP------ 872

Query: 557  TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS-GPEGGAA 615
                       L P P  PPS + S+  S  + +    + T +  +L+   S GP    +
Sbjct: 873  -----------LPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPH--KS 919

Query: 616  ASPPPDAELAACHPAAWSRGPAPPLAFR--GAPGAPLPWPPA---TGPGSADGLCTIYET 670
             +PPP   L    P   +  P PP  F+    P   LP P A          G+    + 
Sbjct: 920  PTPPPTLHLV---PEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKA 976

Query: 671  EGPESATPAPGALDPGPSPGTS---GGKAAAGAGAGASSRSPKQARLGELPLGALQASVV 727
             G  +A     +L P  SP  S    G+A +G    A S +P  A +    L  L  +  
Sbjct: 977  GGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPT-APSHAPAPAPMAATGLPPLLPAEN 1035

Query: 728  QHLLSRTLLLAAAEGAAGGSGGGPG 752
            +   S    L  A+ A+ G G   G
Sbjct: 1036 KAFASNLPTLNVAKAASSGPGKPSG 1060



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 195/799 (24%), Positives = 262/799 (32%), Gaps = 117/799 (14%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A  P L  P       PPP   PA    +     +G +    +A       IP +AP  
Sbjct: 710  SAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLK 769

Query: 78   GPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 137
            GP  +S P    +          SP P   P      +RP    Q   R  +E  +    
Sbjct: 770  GPGPSSSPSLPHQAPLGDSPHLPSPHPTRPP------SRPPSRPQSVSRPPSEPPLHPCP 823

Query: 138  ATEAPK--------RSALSAGARRDTSGPT-PGTPSPAMARRSRAAGTEVGLPRPAPSAR 188
              +AP         ++ L          PT PG P P +  +S+          P P A 
Sbjct: 824  PPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPP------EGPLPPA- 876

Query: 189  PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 248
            P  P      +V+S+SE S+  P+P       +   LQ P S+    S TP        P
Sbjct: 877  PHLPPSSTSSAVASSSETSSRLPAPT-----PSDFQLQFPPSQGPHKSPTP-------PP 924

Query: 249  SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA--------------------APALG 288
            +    P  PA P  P P+  Q +  P    P+  A                    APA  
Sbjct: 925  TLHLVPE-PAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAP 983

Query: 289  PLSSS--PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH----SFL 342
              S+S  PL +P+ S   S  AP    T PS    P   A T L  P L A +    S L
Sbjct: 984  QTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGL-PPLLPAENKAFASNL 1042

Query: 343  PSPPLSPLATPPPQAPPAL----ALPPLQAPPSPPASPP--------------LSP-LAT 383
            P+  ++  A+  P  P  L     L  L+ PP+   S                L P   T
Sbjct: 1043 PTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKT 1102

Query: 384  PSPQAPNA----LAVHLLQAPF-SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 438
              P   +A    L  H+ Q    SP     V   F   ++  +  +    ++    L   
Sbjct: 1103 AFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEE 1162

Query: 439  PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP----QAPPALATPPLQALPS 494
              +V P    S  M        Q      A   QLAK  P     +  +L  P   A  S
Sbjct: 1163 SRRVSP----SAEMVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLP--IAASS 1216

Query: 495  PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG 554
                 PG  P S SA     P A+  P  PP L   L+        SP++   R   +  
Sbjct: 1217 EGHRLPGHGPLSSSA-----PGASTQP--PPHLPTKLVIRHGGAGGSPSVTWARASSSLS 1269

Query: 555  PDTSVSGPRLTL-ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGG 613
              +S S    +L A   GP P  +R P  T       G            +   +     
Sbjct: 1270 SSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDP 1329

Query: 614  AAASPPPDAELAACHPAAWSRGPAPPLA-FRGAPGAPLPWPPATGPGSADGLCTIYETEG 672
                PPP A L    P      P PP     G    P P  P   P      C       
Sbjct: 1330 VHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHC----PRL 1385

Query: 673  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQ--ASVVQHL 730
            P   T       PG   GT  G+A  G      S +P  A++ E   G ++  A+V   L
Sbjct: 1386 PLRKTYRENVGGPGAPEGTPAGRARGG------SPAPLPAKVDEATSGLIRELAAVEDEL 1439

Query: 731  LSRTLLLAAAEGAAGGSGG 749
              R L     E AA  + G
Sbjct: 1440 YQRMLKGPPPEPAASAAQG 1458



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 100/358 (27%), Positives = 131/358 (36%), Gaps = 56/358 (15%)

Query: 13   AARTPAARAPGLLTPRPPGSPRP-PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA--- 68
            A  TP A+  GL    P     P P P  PAA  + G   +    P       +G +   
Sbjct: 734  APATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPS--SSPSLPHQAPLGDSPHL 791

Query: 69   -----TIPESAPRAGPTRTSRPPASGRGERAPP--AKNTSPG--------PVSSPGRASG 113
                 T P S P + P   SRPP+       PP  A  T PG         V  P     
Sbjct: 792  PSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPA 851

Query: 114  TTRPGPLGQKGLRISAEETVARGKATEAP------KRSALSAGARRDTSGPTPGTPSPAM 167
             T PGP  Q  LR  ++     G    AP        SA+++ +   +  P P TPS   
Sbjct: 852  PTAPGP-PQPPLRPQSQP--PEGPLPPAPHLPPSSTSSAVASSSETSSRLPAP-TPSDFQ 907

Query: 168  ARRSRAAGTEVGLPRPAPS----ARPRPPTEGPRKSVSSASEHSTTEPSPAA-----RRR 218
             +   + G     P P P+      P  P   P ++    +      P P A      + 
Sbjct: 908  LQFPPSQGPHKS-PTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQV 966

Query: 219  PS-------AGGGLQRPASRSLSSSATPLSSPAR----SGPSARGTPRAPAHPSQPKPKG 267
            PS       AGG    PA+   S+S  PL+SPA     SG +  GTP AP+H   P P  
Sbjct: 967  PSGIILQNKAGGA---PAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMA 1023

Query: 268  LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQ 325
               L PP +    K  A  L  L+ +  A+  P  P        L  L  PP   PS+
Sbjct: 1024 ATGL-PPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSK 1080



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 162/725 (22%), Positives = 228/725 (31%), Gaps = 110/725 (15%)

Query: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES 73
            A  PA  APG   P+PP  P+  PP  P               P +  +  +  ++   S
Sbjct: 847  ASNPAPTAPG--PPQPPLRPQSQPPEGPLP--------PAPHLPPSSTSSAVASSSETSS 896

Query: 74   ---APRAGPTRTSRPPASG--RGERAPPAKNTSPGPVSSPGRASGT----TRPGP-LGQK 123
               AP     +   PP+ G  +    PP  +  P P + P     T    T P P L Q 
Sbjct: 897  RLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQP 956

Query: 124  GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG---L 180
               +     V  G   +     A +A     + GP     +  +      +GT       
Sbjct: 957  KALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHA 1016

Query: 181  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP---------SAGGGLQRPASR 231
            P PAP A    P   P ++ + AS   T   + AA   P         S   GL++P + 
Sbjct: 1017 PAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTL 1076

Query: 232  SLSSSATPLSSPARSGPSARGTPRAPAHPS-----------------QPKPKGLQALRPP 274
              S  A  L    +   S        A PS                  P P     +   
Sbjct: 1077 QPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEE 1136

Query: 275  QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSL----------------QTLPSP 318
              T   +        L+   L     S   SPSA   +                + L   
Sbjct: 1137 FETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKE 1196

Query: 319  PATPPSQATTSLGSPTLQAT--HSFLPSPPLSPLAT-----PPPQAPPALALPPLQAPPS 371
                   ++ SLG P   ++  H      PLS  A      PPP  P  L +    A  S
Sbjct: 1197 KPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGS 1256

Query: 372  PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS---PPVQA--PFSPPASPPVSPSAT 426
            P  +   +  +  S  + ++ A  L      P PS   PP++     S            
Sbjct: 1257 PSVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEA 1316

Query: 427  PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486
              S+   + A  P+  PP PPA+  ++     PP  PPP       +  PPP AP     
Sbjct: 1317 GLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAP---ER 1373

Query: 487  PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 546
             PL   P  P   P +  +  +   P +P  TP  +A     APL    P+     T   
Sbjct: 1374 KPLGTAPHCP-RLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPL----PAKVDEATSGL 1428

Query: 547  PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 606
             R       + +     L   +  GPPP P+ S +     PD       A   P   R  
Sbjct: 1429 IR-------ELAAVEDELYQRMLKGPPPEPAASAAQGTGDPDW-----EAPGLPPAKRRK 1476

Query: 607  DSGPEGGAAA----SPPPDAELAACHPA---------AWSRGPAPPLAFRGAPGAPLPWP 653
               P+   A+    SP  D        A         A  R PAP      + G P   P
Sbjct: 1477 SESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPP 1536

Query: 654  PATGP 658
            P   P
Sbjct: 1537 PLHRP 1541



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 96/364 (26%), Positives = 130/364 (35%), Gaps = 104/364 (28%)

Query: 173  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSP-----AARRRPSAGGG--- 224
            ++   +GLP  A S   R P  GP   +SS++  ++T+P P        R   AGG    
Sbjct: 1203 SSSRSLGLPIAASSEGHRLPGHGP---LSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSV 1259

Query: 225  LQRPASRSLSSSATPLSS------------PARSGPSAR--------------------- 251
                AS SLSSS++  S+            P+R+ P  +                     
Sbjct: 1260 TWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLS 1319

Query: 252  ----GTPRAPAHPSQPKPKGLQALRPPQVTPP--------------RKDAAPALGPLSSS 293
                 T   P H   P P  L+   PP   PP                 AAP   PL ++
Sbjct: 1320 KVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTA 1379

Query: 294  PLATPSP---------SAPPSPSAPPSLQTLPSPPATPPS---QATT----SLGSPTLQA 337
            P     P           P +P   P+ +     PA  P+   +AT+     L +   + 
Sbjct: 1380 PHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDEL 1439

Query: 338  THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA------SPPL--SPLATPSPQAP 389
                L  PP  P A+    A      P  +AP  PPA      SP +  +  ++ SPQ  
Sbjct: 1440 YQRMLKGPPPEPAAS----AAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQ-D 1494

Query: 390  NALAVH----------LLQAP-FSPPPSPPVQAPFSPPASPPV--SPSATPPSQAPPSLA 436
            + L  H          L QAP  +P PS P  A    PASPP    P A PPS     L 
Sbjct: 1495 DTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHNGGLG 1554

Query: 437  APPL 440
            A  L
Sbjct: 1555 ARTL 1558



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 132/504 (26%), Positives = 175/504 (34%), Gaps = 68/504 (13%)

Query: 225 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPK--------GLQALRPPQV 276
           L+  A   L     P   PA  G    G   A A  + P+          GLQ   PP V
Sbjct: 118 LEAEAELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQG--PPTV 175

Query: 277 ------TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSL 330
                  PP+     AL   S  P   P      +    P LQ LP+   +P      +L
Sbjct: 176 LTHQALVPPQDVVNKAL---SVQPFLQPVGLGNVTLQPIPGLQGLPN--GSPGGATAATL 230

Query: 331 GSPTLQATHSFLPSPPLSPLATPPPQA-PPALALPPLQAPPSPPASPPLSPLATPSPQAP 389
           G   +Q         P+  L TP  Q     + +    A  + P+ P     A  SPQ  
Sbjct: 231 GLAPIQVV-----GQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGA 285

Query: 390 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
             +    L A  +   +       +  AS   +P+ TP  Q  P   AP L   P  PA 
Sbjct: 286 GLVIQKNLSAAVATTLNGNSVFGGAGAAS---APTGTPSGQ--PLAVAPGLGSSPLVPA- 339

Query: 450 PPMSPSATPPPQAPPPLAA-PPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
           P +    TP P  P P    PP      P    PA AT  +Q         PG  P  P 
Sbjct: 340 PNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQ-------GEPGALPQQPK 392

Query: 509 ASLPMSPLATPPPQAPPVLA---APLLQ--VPPSPPASPTLQAPRRPPTPGPDTSVSGPR 563
           A   ++ +A        VL+   AP LQ  V   PPA+ T  AP +PP      ++S P 
Sbjct: 393 APQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQPP-----GALSKPM 447

Query: 564 LTLALAPGPP---PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGG--AAASP 618
               L  G     P     P             + A   P++L    +   G   AAA+P
Sbjct: 448 SVHLLNQGSSIVIPAQHMLPGQN----QFLLPGAPAVQLPQQLSALPANVGGQILAAAAP 503

Query: 619 PPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATP 678
               +L A +P   ++  A PL+     G  L   P +G  SA  L       G  +   
Sbjct: 504 HTGGQLIA-NPILTNQNLAGPLSL----GPVL--APHSGAHSAHILSAAPIQVGQPALFQ 556

Query: 679 APGALDPGPSPGTSGGKAAAGAGA 702
            P +L  G  P T    A AG  A
Sbjct: 557 MPVSLAAGSLP-TQSQPAPAGPAA 579



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 88/368 (23%), Positives = 125/368 (33%), Gaps = 67/368 (18%)

Query: 13   AARTPAARAPGL--LTPRPPGSPRPPPPVTPAALRVL-GAAGAVGRKPLAERAGGIGGAT 69
            AA +   R PG   L+   PG+   PPP  P  L +  G AG       A  +  +  ++
Sbjct: 1213 AASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSS 1272

Query: 70   IPESAPRA------GPTRT-SRPPASGRGERA---------------PPAKNTSPGPVSS 107
               SA  +      GP  + +RPP      R+                   NT+  PV  
Sbjct: 1273 SSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQ 1332

Query: 108  PGRASGTTR-----------PGPLGQKGLRI-----SAEETVARGKATEAPKRSALSAGA 151
            P     T +           P P GQ    +     +A E    G A   P R  L    
Sbjct: 1333 PPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCP-RLPLRKTY 1391

Query: 152  RRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP 211
            R +  GP  G P    A R+R      G P P P A+    T G  + +++  +      
Sbjct: 1392 RENVGGP--GAPEGTPAGRARG-----GSPAPLP-AKVDEATSGLIRELAAVEDELYQRM 1443

Query: 212  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 271
                         L+ P     +S+A     P    P      R  +           + 
Sbjct: 1444 -------------LKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSD 1490

Query: 272  RPPQ--VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA--PPSLQTLPSPPATPPSQAT 327
             P    +T   + A  ++  L  +P  TP+PS P + SA  P S   L  P A PPS   
Sbjct: 1491 SPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHN 1550

Query: 328  TSLGSPTL 335
              LG+ TL
Sbjct: 1551 GGLGARTL 1558


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score =  139 bits (349), Expect = 1e-32
 Identities = 203/828 (24%), Positives = 277/828 (33%), Gaps = 152/828 (18%)

Query: 25   LTPRPPGSPRPPPPVTP--AALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR- 81
            L P PPG P PP        +     A+        A  +  +G  T        G T  
Sbjct: 510  LDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAG 569

Query: 82   TSRPPASGRGERAPPAKNTSPGPV-------SSPGRASGTTRPGPLGQKGLRISAEETVA 134
              RPP  G G  A P+K T   P+         P    G   PGP       + A     
Sbjct: 570  PLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGP------SVIAAPPSG 623

Query: 135  RGKATEA----PKRSALSAGARRDTSGPTP----GTPSPAMARRSRAAGTEVGLP---RP 183
             G   +     P +     G  R  S P P    G P+  ++R +    T V  P    P
Sbjct: 624  GGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTP 683

Query: 184  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
             P A    PT G  ++  + +  + TE    +R    +  G+    S   S++AT  +  
Sbjct: 684  VPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPH 743

Query: 244  ARSGPSARGTPRAPAHPSQ----------PKPKGLQAL---RPPQVTPPRKDAAPALGPL 290
              +GP      +APA  +           P P  +Q +    P   T     A    GP 
Sbjct: 744  LVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPN 803

Query: 291  SSSPLATPSPSAPPS-----------PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 339
               PL    P A              P+ P  LQ  P+P   P ++A    G     +  
Sbjct: 804  GPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIR 863

Query: 340  SFLPSPPLSPLATPPPQAPPALALPPLQAPPS--PPASPPLSPLATPSPQAPNALAVHLL 397
              LP P  S          P   +P LQ+ PS  PP +  +SP+  P P     L    +
Sbjct: 864  FTLP-PGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKV 922

Query: 398  QAPFSPP-----------PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 446
              P + P           P P V    SPP S PV   A PPS+    +   P+ V    
Sbjct: 923  LVPLAAPSMSVRGGGAGQPLPLV----SPPFSVPVQNGAQPPSKI---IQLTPVPVSTPS 975

Query: 447  PASPPMSPSATPPPQAPPPLA-----------------APPLQLAKPPPQAPPALATPPL 489
               PP+SP+  P P + P                    A PL  +    QA    +  P 
Sbjct: 976  GLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPT 1035

Query: 490  QAL--------PSPPASF-----PGQAPFSPSASLPMSPLATPPPQAPPVLAA---PLLQ 533
             ++        PS PA        GQAP      + +SP+  P PQ PP  AA   P++ 
Sbjct: 1036 SSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPV--PSPQLPPACAAPGGPVIT 1093

Query: 534  VPPSPPASPTLQAPRRPPTPGPD-------TSVSGPRLTLALAPGPPPPPSRSPSSTLSG 586
               S   +PT  AP   P+  P        TS + P  T+ L  GPP P + +P+ T   
Sbjct: 1094 AFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATI-LPKGPPAPATATPAPTSPF 1152

Query: 587  PD-LAGHSSSATSTPEELRGYDSGP---------------EGGAAASPPPDAELAACHPA 630
            P   AG  + +   P+  R     P               E GA+  P P A      P 
Sbjct: 1153 PSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGP-APRQPLEPG 1211

Query: 631  AWSRGPAPPLAFRGAPGAPLP------W-----------PPATGPGSADG---LCTIYET 670
                  AP     G P  P P      W           PPA    SA G   + + + +
Sbjct: 1212 PVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPS 1271

Query: 671  EGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 718
               +   P  G  + G  P       A     G SS S      G+ P
Sbjct: 1272 SSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTP 1319



 Score =  138 bits (347), Expect = 2e-32
 Identities = 212/773 (27%), Positives = 272/773 (35%), Gaps = 152/773 (19%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
            G  AR P+A AP L    P       P   PAA  V      V   P+      I     
Sbjct: 642  GGGARVPSAPAPSLAYGAPAA-----PLSRPAATMVTNVVRPVSSTPVP-----IASKPF 691

Query: 71   PESA-PRAGPTRTSRPPAS-GRGERAP---------------PAKNTSPGPVSSPGRASG 113
            P S    A P  T+      G G R P                A  TSP P    G   G
Sbjct: 692  PTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLG 751

Query: 114  TTRPGPLGQKGLRIS----------AEETVARGKATEAPKRSALSAGARRDTSGPTP-GT 162
            T    P     L +           A + +A+G A      +   AGA    +GP P G 
Sbjct: 752  TVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQG-APGGGTTAGSGAGAGSGPNGPVPLGI 810

Query: 163  PSP-AMARRSRAAGTEVGLP------RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA 215
              P A+ +       +  LP      + AP+  P P T+    S           P+P  
Sbjct: 811  LQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPS----------GPAPTT 860

Query: 216  RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 275
              R +   G         +++ TP            G P   + PS P PK  Q++ P Q
Sbjct: 861  SIRFTLPPGTSTNGKVLAATAPTP------------GIPILQSVPSAPPPKA-QSVSPVQ 907

Query: 276  VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335
              PP   A    G +   PLA PS S     +  P    L SPP + P Q      S  +
Sbjct: 908  APPPGGSAQLLPGKVLV-PLAAPSMSVRGGGAGQPL--PLVSPPFSVPVQNGAQPPSKII 964

Query: 336  QATHSFLPSP-----PLSPLATPPPQAPPALALPPLQ------------APP--SPPASP 376
            Q T   + +P     PLSP   P P + P   L P              A P  + PAS 
Sbjct: 965  QLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASS 1024

Query: 377  PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV----QAPFSPPASPPVSPSATPPSQAP 432
                + +  P +  AL    L  P  P    P+    QAP   P    VSP  +P  Q P
Sbjct: 1025 QAGTVTSYGPTSSVALGFTSL-GPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSP--QLP 1081

Query: 433  PSLAAPPLQV-------PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP-----PQA 480
            P+ AAP   V        P+P +S P++     P QAPP L         PP     P+ 
Sbjct: 1082 PACAAPGGPVITAFYSGSPAPTSSAPLAQ----PSQAPPSLVYTVATSTTPPAATILPKG 1137

Query: 481  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP----P 536
            PPA AT    A P+P + FP     S + SL       P P+AP  + A +  +P     
Sbjct: 1138 PPAPAT----ATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFE 1193

Query: 537  SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA 596
            +  +     APR+P  PGP    + P   L   P PP PP    + T +       SS  
Sbjct: 1194 AGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPT-----ARSSPP 1248

Query: 597  TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656
               P E R    GPE  A+  P   ++        W R P   L  RG P  P P  PA 
Sbjct: 1249 LPPPAEERTSAKGPETMASKFPSSSSD--------W-RVPGQGLENRGEP--PTPPSPAP 1297

Query: 657  GPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 709
             P  A G        G   ++    A D      T   K AAG G     R P
Sbjct: 1298 APAVAPG--------GSSESSSGRAAGD------TPERKEAAGTGKKVKVRPP 1336



 Score =  127 bits (319), Expect = 4e-29
 Identities = 177/732 (24%), Positives = 252/732 (34%), Gaps = 98/732 (13%)

Query: 28   RPPGSPRPPPPVTPAALRVLG--------AAGAVGRKPLAERAGGIGGATIPESAPRAGP 79
            RPP  P PP P  P      G        A+        A  +  +G  T        G 
Sbjct: 507  RPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGS 566

Query: 80   TRTS-RPPASGRGERAPPAKNTSPGPVSS-------PGRASGTTRPGPLGQKGLRISAEE 131
            T    RPP  G G  A P+K T   P+         P    G   PGP       + A  
Sbjct: 567  TAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGP------SVIAAP 620

Query: 132  TVARGKATEA----PKRSALSAGARRDTSGPTP----GTPSPAMARRSRAAGTEVGLP-- 181
                G   +     P +     G  R  S P P    G P+  ++R +    T V  P  
Sbjct: 621  PSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVS 680

Query: 182  -RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240
              P P A    PT G  ++  + +  + TE    +R    +  G+    S   S++AT  
Sbjct: 681  STPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSP 740

Query: 241  SSPARSGPSARGTPRAPAHPSQ----------PKPKGLQALR---PPQVTPPRKDAAPAL 287
            +    +GP      +APA  +           P P  +Q +    P   T     A    
Sbjct: 741  APHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGS 800

Query: 288  GPLSSSPLATPSPSAPPS-----------PSAPPSLQTLPSPPATPPSQATTSLGSPTLQ 336
            GP    PL    P A              P+ P  LQ  P+P   P ++A    G     
Sbjct: 801  GPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTT 860

Query: 337  ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS--PPASPPLSPLATPSPQAPNALAV 394
            +    LP P  S          P   +P LQ+ PS  PP +  +SP+  P P     L  
Sbjct: 861  SIRFTLP-PGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLP 919

Query: 395  HLLQAPFSPP-----------PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443
              +  P + P           P P V    SPP S PV   A PPS+    +   P+ V 
Sbjct: 920  GKVLVPLAAPSMSVRGGGAGQPLPLV----SPPFSVPVQNGAQPPSKI---IQLTPVPVS 972

Query: 444  PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQA 503
                  PP+SP+  P P + P     P        Q+    A P    L + PAS     
Sbjct: 973  TPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALP----LGTSPASSQAGT 1028

Query: 504  --PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG--PDTSV 559
               + P++S+ +   +  P  + P    PLL    +P  +P        P+P   P  + 
Sbjct: 1029 VTSYGPTSSVALGFTSLGP--SGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAA 1086

Query: 560  SGPRLTLALAPGPPPPPSRSPSSTLS-GPDLAGHSSSATSTPEELRGYDSGPEGGAAASP 618
             G  +  A   G P P S +P +  S  P    ++ + ++TP        GP   A A+P
Sbjct: 1087 PGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATP 1146

Query: 619  PPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATP 678
             P +   +    + +     P A R +P AP     A           +   E   S  P
Sbjct: 1147 APTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIAS------IPVGSFEAGASGRP 1200

Query: 679  APG---ALDPGP 687
             P     L+PGP
Sbjct: 1201 GPAPRQPLEPGP 1212



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 139/555 (25%), Positives = 198/555 (35%), Gaps = 55/555 (9%)

Query: 8    AKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67
            A A  A +  A  APG  T    G+     P  P  L +L   GA+G+      AGGI  
Sbjct: 772  APAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGIL-QPGALGK------AGGITQ 824

Query: 68   AT-IPESAPRAGPTRTSRPPASGRGERAP--PAKNTS-----PGPVSSPGRASGTTRPGP 119
               I  + P+      +  PA G    AP  PA  TS     P   S+ G+    T P P
Sbjct: 825  VQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTP 884

Query: 120  LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT-----PSPAMARRSRAA 174
                   I   ++V      +A   S + A     ++   PG       +P+M+ R   A
Sbjct: 885  ------GIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGA 938

Query: 175  GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 234
            G  + L  P  S   +   + P K +       +T         P+   G      + L 
Sbjct: 939  GQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLL 998

Query: 235  SSATPLSSPARSGPSARGTPRAPAH----------PSQPKPKGLQALRP--PQVTPPRKD 282
             S+T ++    +G  A     +PA           P+     G  +L P  P    P   
Sbjct: 999  PSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLS 1058

Query: 283  A--APALGPLSSSPLATPSPSAPPSPSAP--PSLQTLPSPPATPPSQATTSLGS---PTL 335
            A  AP L P        PSP  PP+ +AP  P +    S    P S A  +  S   P+L
Sbjct: 1059 AGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSL 1118

Query: 336  QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395
              T +   +PP + +    P AP      P    PS  A      L  P  Q P+  A  
Sbjct: 1119 VYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQ 1178

Query: 396  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 455
             ++A  +  P    +A  S    P       P     P+     L+  P+PPA PP+  +
Sbjct: 1179 KVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPET 1238

Query: 456  ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 515
             TP  ++ PPL         PP +   +   P   A   P +S   + P     +    P
Sbjct: 1239 WTPTARSSPPL--------PPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPP 1290

Query: 516  LATPPPQAPPVLAAP 530
              TPP  AP    AP
Sbjct: 1291 --TPPSPAPAPAVAP 1303



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 193/821 (23%), Positives = 278/821 (33%), Gaps = 191/821 (23%)

Query: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
            PAS  G + P  +  +PGP ++PG        G       R S  +  A    T   +R 
Sbjct: 383  PASYSGPK-PSTQYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERM 441

Query: 146  AL----------------------------SAGARRDTSGPTP----GTPSPAMARRSRA 173
             +                            +     D+SG  P    G      +   R+
Sbjct: 442  VICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRS 501

Query: 174  AGTEVGLP-RPAPSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 230
            + T    P  P P   P PP    +   S  S+S  S    S +A    S G G  +   
Sbjct: 502  SFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQE 561

Query: 231  RSLSSSATPL-------SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP--------- 274
                S+A PL         PA    + R  P  PA   + +P+ +  L PP         
Sbjct: 562  SGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPP 621

Query: 275  ---------QVTPPRKDAAPALGP-LSSSPLATPSPSAPPSPSAPPS----------LQT 314
                      V PP K+     G  + S+P  + +  AP +P + P+          + +
Sbjct: 622  SGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSS 681

Query: 315  LPSPPATPP--------SQATTSLGSPTLQATHSFLP-----------SPPLSPLATPPP 355
             P P A+ P        +    + G+ T   T S +P           S   S  AT P 
Sbjct: 682  TPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSP- 740

Query: 356  QAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ-------------APFS 402
             AP  +A P L      PA+     + TP   AP   AV  +              A   
Sbjct: 741  -APHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAG 799

Query: 403  PPPSPPV-----------------QAPFSPPASPPVSPSATPPSQAPPSLAAPP------ 439
              P+ PV                 Q  +  P  P     A  P+ AP + AA P      
Sbjct: 800  SGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPT 859

Query: 440  ----LQVPPSPPASPPMSPSATPPPQAP----PPLAAPPLQLAKPPPQAPPALATPPLQA 491
                  +PP    +  +  +  P P  P     P A PP   +  P QAPP   +   Q 
Sbjct: 860  TSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGS--AQL 917

Query: 492  LPSP---PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA----PLLQVPPSPPASPT- 543
            LP     P + P  +     A  P+ PL +PP   P    A     ++Q+ P P ++P+ 
Sbjct: 918  LPGKVLVPLAAPSMSVRGGGAGQPL-PLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSG 976

Query: 544  LQAPRRPPT-PGPDTS------VSGPRLTL-------ALAPGPPPPPSRSPSSTLSGPDL 589
            L  P  P T PGP +        S  R+T        AL  G  P  S++ + T  GP  
Sbjct: 977  LVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTS 1036

Query: 590  A---GHSSSATSTP---EELRGYDSGP---EGGAAASPPPDAELAACHPAAWSRGPAPPL 640
            +   G +S   S P   + L      P    G    SP P  +L    PA  + G     
Sbjct: 1037 SVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLP---PACAAPGGPVIT 1093

Query: 641  AFRGAPGAPLPWPPATGPGSADG--LCTIYETEGPESAT------PAPGALDPGPS---- 688
            AF     AP    P   P  A    + T+  +  P +AT      PAP    P P+    
Sbjct: 1094 AFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFP 1153

Query: 689  PGTSGGKAAAGAGAGASSRSPK-----QARLGELPLGALQA 724
              T+G    +     A   SPK     +A +  +P+G+ +A
Sbjct: 1154 SATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEA 1194



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 137/560 (24%), Positives = 183/560 (32%), Gaps = 141/560 (25%)

Query: 21   APGLLTPRPPGSPRPPPPVTPAALRVL-----GAAGAVGRKPLAERAGGIGGATIPESAP 75
            APG +   P  SP+ PP        V+     G+       PLA+ +          +  
Sbjct: 1066 APGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATS 1125

Query: 76   RAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGR------ASGTTRPGPLGQKGLR--- 126
               P  T  P        A PA  TSP P ++ G       A    RP P   + ++   
Sbjct: 1126 TTPPAATILPKGPPAPATATPAP-TSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAI 1184

Query: 127  ----ISAEETVARGKATEAPKRSALSAGARRDTSG-------PTPGTPSPAMARRSRAAG 175
                + + E  A G+   AP++       R  T+        PTP  P P     +  A 
Sbjct: 1185 ASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTAR 1244

Query: 176  TEVGLPRPAPSARPRPPTEGPRKSVSSASEHST----------------TEPSPAARRRP 219
            +   LP   P A  R   +GP    S     S+                T PSPA     
Sbjct: 1245 SSPPLP---PPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAV 1301

Query: 220  SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS---------------QPK 264
            + GG  +  + R+     TP    A +G   +   R P                   + +
Sbjct: 1302 APGGSSESSSGRAAGD--TPERKEA-AGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEER 1358

Query: 265  PKGLQALRPPQVTPPRKDAAPALGPLSSSPLA------------TPSPSAPPSPSAPPSL 312
               L   RP +V P     +P L  L++SP A            T   SAP  P++P   
Sbjct: 1359 FAELPEFRPEEVLP-----SPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRK 1413

Query: 313  Q----TLPSPPATPPS---------------QATTSLGS--------PTLQAT------- 338
                 +  S P TP S               +A   LG          +L+ T       
Sbjct: 1414 MRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRAL 1473

Query: 339  -------HSFLPSPPLSPLATPPPQAPPALALPP---LQAPPSPPASPPLSPLATPSPQA 388
                   H F PS      AT   QA  A   P    LQ          +   ATP+ Q 
Sbjct: 1474 VMQLFQDHGFFPSAQ----ATAAFQARYADIFPSKVCLQLKIRE-VRQKIMQAATPTEQP 1528

Query: 389  PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ-APPSLAAPPLQVPPSPP 447
            P A      +AP   PP     A  +P  SP   P  T PS  +  + AAPPL   P PP
Sbjct: 1529 PGA------EAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPL---PPPP 1579

Query: 448  ASPPMSPS--ATPPPQAPPP 465
             S P  P     P P  PPP
Sbjct: 1580 ESGPGQPGWEGAPQPSPPPP 1599



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 103/382 (26%), Positives = 135/382 (35%), Gaps = 56/382 (14%)

Query: 406 SPPVQAPFS---PPASPPVSPSATPP-------SQAPPSLAAPPLQVPPSPPASPPMSPS 455
           SP +++ F+   PP  P       PP         AP S A+ P     S   S  +   
Sbjct: 496 SPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSG 555

Query: 456 ATPPPQAPPPLAAPPLQLAKPPPQAP-PALATPPLQALPSPPASFPGQAPFSPSASLPMS 514
                ++     A PL+   PPP A  PA  +   + LP  PA+F  + P S     P  
Sbjct: 556 TFKAQESGQGSTAGPLR--PPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPG 613

Query: 515 PLATPPPQAPPVLAAPLLQVPPSPPASPTLQA--PRRPPTPGPDTSVSGPRLTLALAPGP 572
           P       APP     +LQ    PP     +    R P  P P           +LA G 
Sbjct: 614 PSVIA---APPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAP-----------SLAYGA 659

Query: 573 PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 632
           P  P   P++T+    +       +STP  +      P  G A + P D   A       
Sbjct: 660 PAAPLSRPAATM----VTNVVRPVSSTPVPIASKPF-PTSGRAEASPNDTAGARTEMGTG 714

Query: 633 SRGPA-PPLAF------RGAPGAPLPWPP-ATGP-----GSADGLCTIYETEGPESATPA 679
           SR P   PL        + +  A  P P    GP     G A    T      P    PA
Sbjct: 715 SRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPA 774

Query: 680 PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL-------QASVVQHLLS 732
           P A+    + G  GG   AG+GAGA S       LG L  GAL       Q   +   L 
Sbjct: 775 PPAVQ-FIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLP 833

Query: 733 RTLLLAAAEGAAGGS-GGGPGG 753
           + L +A A   A G+    P G
Sbjct: 834 QQLQVAPAPAPAPGTKAAAPSG 855



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 158/693 (22%), Positives = 215/693 (31%), Gaps = 142/693 (20%)

Query: 16   TPAARAPGLLTPRPPGSPRPPPPVT-PAALRVL------GAAGAVGRKPLAERAGGIGGA 68
            TP+   P L     PG    P  V  P++ R+       G A  +G  P + +AG +   
Sbjct: 973  TPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSY 1032

Query: 69   TIPESAPRAGPTRTSRPPASGRGERAP----PAKNTSPGPVSSPGRASGTTRPGPLGQKG 124
                     GPT +     +  G   P    P  +    P+ +PG+   +  P P     
Sbjct: 1033 ---------GPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSP----- 1078

Query: 125  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 184
                  +      A   P  +A  +G+   TS      PS A         T    P   
Sbjct: 1079 ------QLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAAT 1132

Query: 185  --PSARPRPPTE--GPRKSVSSASEHSTT---------EPSPAARRRPSAG--------- 222
              P   P P T    P     SA+  S T          PSP A ++  A          
Sbjct: 1133 ILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSF 1192

Query: 223  ----GGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 278
                 G   PA R       P+  P        G P  PA P  P+     A   P + P
Sbjct: 1193 EAGASGRPGPAPRQPLEPG-PVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPP 1251

Query: 279  PRKDAAPALGP--------LSSSPLATPS------------PSAPPSPSAPPSLQTLPSP 318
            P ++   A GP         SSS    P             PS  P+P+  P   +  S 
Sbjct: 1252 PAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSS 1311

Query: 319  PA----TPPSQATTSLGS------PTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA 368
                  TP  +     G       P L+ T   + +  LS +           A  P   
Sbjct: 1312 GRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEV-----DFEERFAELPEFR 1366

Query: 369  PPSPPASPPLSPLATPSPQA-------PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 421
            P     SP L  LAT SP+A           +  L  AP  P          S  +S P 
Sbjct: 1367 PEEVLPSPTLQSLAT-SPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPN 1425

Query: 422  SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL---AAPPLQLAKPPP 478
            +P +   ++    +         +      +     P       L    A  +QL +   
Sbjct: 1426 TPKS---AKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHG 1482

Query: 479  QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPP 536
              P A AT   QA  +    FP +             +  A  P + PP   APL    P
Sbjct: 1483 FFPSAQATAAFQARYAD--IFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPL----P 1536

Query: 537  SPPASPTLQAPRRPPTP--GPD-TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHS 593
             PP + T  AP   P+P  GPD TS S    T   AP  PPPP   P             
Sbjct: 1537 VPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQP---------- 1586

Query: 594  SSATSTPEELRGYDSGPEGGAAASPPPDAELAA 626
                       G++  P+    + PPP    AA
Sbjct: 1587 -----------GWEGAPQ---PSPPPPGPSTAA 1605



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 48/188 (25%), Positives = 72/188 (38%), Gaps = 26/188 (13%)

Query: 278 PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQA 337
           P    A+  LG    + +   S +  P  S  P L      P+  PS+A           
Sbjct: 10  PASSAASRGLGMFVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQ---------- 59

Query: 338 THSFLPSPPLSPLATPPPQAPPALALPPLQAPP--SPPASPPLSPLAT----PSPQAPNA 391
                  P   P+A+   + P   A    + PP  +  A P   P AT    P P  P+ 
Sbjct: 60  ------QPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHP 113

Query: 392 LAVHLLQAPFSPPPSPPVQAPFSPPASPPV-SPSATPPSQAPPSLAAPPLQVPPSPPASP 450
           L V  +++   PPP+   +A   PP  P + S + +    A  S+ +P +Q+P  P    
Sbjct: 114 LGV--VESGKGPPPTTEEEAS-GPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRR 170

Query: 451 PMSPSATP 458
             S SA P
Sbjct: 171 TQSLSALP 178



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 30/108 (27%), Positives = 38/108 (35%), Gaps = 15/108 (13%)

Query: 227  RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 286
            R   + +  +ATP   P          P A A    P P G  A   P  TP        
Sbjct: 1512 REVRQKIMQAATPTEQP----------PGAEAPLPVPPPTGTAAAPAP--TPSPAGGPDP 1559

Query: 287  LGPLSSSPLATPSPSAPPSPSA---PPSLQTLPSPPATPPSQATTSLG 331
              P S S  A  +P  PP P +    P  +  P P   PP  +T + G
Sbjct: 1560 TSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATG 1607



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)

Query: 389 PNALAV---HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 445
           P ++AV   H L  PF  P  P      S    P   P A+  S+ P   AA   + PP 
Sbjct: 29  PRSVAVFPWHSL-VPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPG 87

Query: 446 PPASP-PMSPSATPPPQAPPPLAAPPLQLAK----PPPQAPPALATPPLQ-ALPSPPASF 499
              S  P  P     P++P P    PL + +    PPP      + PP +  L S   S 
Sbjct: 88  GTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESD 147

Query: 500 PGQA---PFSPSASLPMSP 515
              A     SP   LP+ P
Sbjct: 148 HDDAFLSIMSPEIQLPLPP 166



 Score = 33.5 bits (75), Expect = 0.82
 Identities = 40/165 (24%), Positives = 52/165 (31%), Gaps = 46/165 (27%)

Query: 182 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 241
           +P PS +P    +     V+S       E +  A  RP  G G           SA P  
Sbjct: 48  QPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTG-----------SADPER 96

Query: 242 SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS 301
            P  + P + G    P HP                          LG + S     P P+
Sbjct: 97  PPGATCPESPGP--GPPHP--------------------------LGVVESG--KGPPPT 126

Query: 302 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP 346
                S PP    L S   +    A  S+ SP +Q     LP PP
Sbjct: 127 TEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQ-----LPLPP 166



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 22/93 (23%), Positives = 28/93 (30%), Gaps = 7/93 (7%)

Query: 80   TRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKAT 139
            T T +PP +      PP   T+  P  +P  A G     P    G       T       
Sbjct: 1523 TPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSG-------TAQAAPPL 1575

Query: 140  EAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 172
              P  S            P+P  P P+ A   R
Sbjct: 1576 PPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR 1608



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 39/149 (26%), Positives = 51/149 (34%), Gaps = 24/149 (16%)

Query: 500 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT-PGPDTS 558
           P  AP  P  S+        P +A    + P+       PA     A  RPP   G    
Sbjct: 42  PFLAPSQPDPSVQ-------PSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADP 94

Query: 559 VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP 618
              P  T   +PGP PP       +  GP          +T EE     SGP G     P
Sbjct: 95  ERPPGATCPESPGPGPPHPLGVVESGKGP--------PPTTEEEA----SGPPG----EP 138

Query: 619 PPDAELAACHPAAWSRGPAPPLAFRGAPG 647
             D+E  + H  A+    +P +     PG
Sbjct: 139 RLDSETESDHDDAFLSIMSPEIQLPLPPG 167


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score =  138 bits (347), Expect = 2e-32
 Identities = 163/567 (28%), Positives = 211/567 (37%), Gaps = 66/567 (11%)

Query: 160 PGTPSPAMARRSRAAGTEV--GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 217
           P TP    A  + A G  V  G P  A  A P  P EG        +  +  EP PA R 
Sbjct: 45  PRTPE-VRAAAAGALGNHVVSGSPAGAAGAGPAAPAEG--------APGAAPEPPPAGRA 95

Query: 218 RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 277
           RP  GGG QRP   S      P + PA      R  P   A    P P        P+  
Sbjct: 96  RPG-GGGPQRPGPPSPRRPLVP-AGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPA 153

Query: 278 PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQA 337
           P    A PA GP + +  A P P   P P   P     P  PA P +  T +  +  L +
Sbjct: 154 PAGP-AKPA-GPAALAARAGPGPGPGPGPGPGPG----PGKPAGPGAAQTLNGSAALLNS 207

Query: 338 THSFLPSP------PLSPLATPPPQAP-PALALPPLQAPPSPPASPPLSPLATPSPQAPN 390
            H+  P+       P + L  P P AP   +  PP     +PPA    SP A P+P AP 
Sbjct: 208 HHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPA 267

Query: 391 ALAVHLLQAPFSPPPSPPVQA-PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
           A       AP  PPP+P   A P   PA PP +  A PP  A  +  +      P+P A 
Sbjct: 268 A-------APPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAG 320

Query: 450 PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
            P   S  P P A     AP ++   P            +QA P    +     P S +A
Sbjct: 321 GPAGVSGQPGPGAAAAAPAPGVKAESP---------KRVVQAAPPAAQTLAASGPASTAA 371

Query: 510 SLPMSPL---ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 566
           S+ + P    A P P A P  A       P   A    Q+  R PT     + SG R TL
Sbjct: 372 SMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPT----ATTSGIRATL 427

Query: 567 ---ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR-GYDSGPEGGAAASPPPDA 622
               LAP  P PP ++P++  +     G     +   + L     +  +  A A   P  
Sbjct: 428 TPTVLAPRLPQPP-QNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQT 486

Query: 623 ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGA 682
            +A   PA  +  P   ++   APG P+     T         TI +       T  P A
Sbjct: 487 TMAP-RPATPTSAPPVQISTVQAPGTPIIARQVTP-------TTIIKQVSQAQTTVQPSA 538

Query: 683 L---DPGPSPGTSGGKAAAGAGAGASS 706
                PG  P    G AA  A  G ++
Sbjct: 539 TLQRSPGVQPQLVLGGAAQTASLGTAT 565



 Score =  113 bits (282), Expect = 8e-25
 Identities = 152/521 (29%), Positives = 192/521 (36%), Gaps = 63/521 (12%)

Query: 8   AKAGAAARTPAARA-PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
           A   A    PA RA PG   P+ PG P P  P+ PA      A  A   +P  E + G  
Sbjct: 82  APGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAG----PAPPAAKLRPPPEGSAGSC 137

Query: 67  GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 126
                 +A  AGP      PA   G  A  A+   PGP   PG   G   PGP    G  
Sbjct: 138 APVPAAAAVAAGPEPAPAGPAKPAGPAALAAR-AGPGPGPGPGPGPG---PGPGKPAGP- 192

Query: 127 ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE--VGLPRPA 184
             A +T+  G A       A +       +GP    P P  A       T   VG   P 
Sbjct: 193 -GAAQTL-NGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPP 250

Query: 185 PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 244
             A P PP   P  +  +A+      P+PA   RP        PA    ++ A P  + A
Sbjct: 251 APAAPSPPA-APAPAAPAAAP-PPPPPAPATLARPPG-----HPAGPPTAAPAVPPPAAA 303

Query: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPP 304
           ++G SA   P APA P+   P G+      Q  P    AAPA G  + SP          
Sbjct: 304 QNGGSAGAAP-APA-PAAGGPAGVSG----QPGPGAAAAAPAPGVKAESPKRVVQ----- 352

Query: 305 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364
             +APP+ QTL +  + P S A + +  PT+Q     LPSP     A  PP AP      
Sbjct: 353 --AAPPAAQTLAA--SGPASTAASMVIGPTMQGA---LPSP-----AAVPPPAPGTPTGL 400

Query: 365 PLQAPPSPPASPPLSPLATPS----PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420
           P  A  +   S   +P AT S       P  LA  L Q P +P      Q P        
Sbjct: 401 PKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLP-------- 452

Query: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 480
             P           L   P Q      A     P  T  P+   P +APP+Q++      
Sbjct: 453 --PGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPG 510

Query: 481 PPALATPPLQALPSPPASFPGQA--PFSPSASLPMSPLATP 519
            P +A    Q  P+       QA     PSA+L  SP   P
Sbjct: 511 TPIIAR---QVTPTTIIKQVSQAQTTVQPSATLQRSPGVQP 548



 Score =  108 bits (269), Expect = 3e-23
 Identities = 110/371 (29%), Positives = 139/371 (37%), Gaps = 24/371 (6%)

Query: 354 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 413
           P  A  A    P +  P     PP +  A P    P        + P  P    P  A  
Sbjct: 67  PAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKL 126

Query: 414 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473
            PP        A  P+ A  +    P    P+ PA P    +   P   P P   P    
Sbjct: 127 RPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGP 186

Query: 474 AKPPPQAPPALATPPLQALPSPPASFPGQAPFS--PSASLPMSPLATPPP--QAPPVL-- 527
            KP               L S  A+ P  +  +  P+A LP+   A P    Q PP +  
Sbjct: 187 GKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGA 246

Query: 528 AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG-PPPPPSRSPSSTLSG 586
           AAP     PSPPA+P   AP   P P P         TLA  PG P  PP+ +P+     
Sbjct: 247 AAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPA-----TLARPPGHPAGPPTAAPAVPPPA 301

Query: 587 PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP 646
               G S+ A   P    G   GP  G +  P P A  AA  PA   +  +P    + AP
Sbjct: 302 AAQNGGSAGAAPAPAPAAG---GP-AGVSGQPGPGA--AAAAPAPGVKAESPKRVVQAAP 355

Query: 647 GAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG--KAAAGAGAGA 704
            A      A+GP S      I  T   + A P+P A+ P P+PGT  G  K AAGA   +
Sbjct: 356 PAAQTL-AASGPASTAASMVIGPT--MQGALPSPAAVPP-PAPGTPTGLPKGAAGAVTQS 411

Query: 705 SSRSPKQARLG 715
            SR+P     G
Sbjct: 412 LSRTPTATTSG 422



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 96/339 (28%), Positives = 122/339 (35%), Gaps = 49/339 (14%)

Query: 443 PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP---PQ--APPALATPPLQALPSPPA 497
           P     + P +P+   P  AP P   PP   A+P    PQ   PP+   P + A P+PPA
Sbjct: 67  PAGAAGAGPAAPAEGAPGAAPEP---PPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPA 123

Query: 498 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPD 556
           +     P   + S        P P A  V A P      P+ PA P   A R  P PGP 
Sbjct: 124 AKLRPPPEGSAGS------CAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPG 177

Query: 557 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE----- 611
               GP       PGP  P     + TL+G     +S  A +    L   ++GP      
Sbjct: 178 PG-PGP------GPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSL--VNNGPAALLPL 228

Query: 612 ------GGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLC 665
                 G    +PP     A   PAA    P+PP A   AP AP   PP   P  A    
Sbjct: 229 PKPAAPGTVIQTPPFVGAAAPPAPAA----PSPPAA--PAPAAPAAAPPPPPPAPATLAR 282

Query: 666 TIYETEGPESATPA---PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL 722
                 GP +A PA   P A   G S G +   A A  G    S  P        P   +
Sbjct: 283 PPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGV 342

Query: 723 QASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTG 761
           +A   + ++      AA   A   +  GP       V G
Sbjct: 343 KAESPKRVVQ-----AAPPAAQTLAASGPASTAASMVIG 376



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 91/320 (28%), Positives = 107/320 (33%), Gaps = 40/320 (12%)

Query: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519
           P+ P   AA    L        PA A     A P+  A  PG AP  P A         P
Sbjct: 45  PRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGA--PGAAPEPPPAGRARPGGGGP 102

Query: 520 PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 579
               PP    PL+   P+PPA     A  RPP  G   S +      A+A GP P P+  
Sbjct: 103 QRPGPPSPRRPLVPAGPAPPA-----AKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPA-G 156

Query: 580 PSSTLSGPDLAGHSSSATST-----PEELRGYDSGPEGGAAASPPPDAELAACHPAAW-- 632
           P+       LA  +           P    G  +GP  GAA +    A L   H AA   
Sbjct: 157 PAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGP--GAAQTLNGSAALLNSHHAAAPA 214

Query: 633 ----SRGPAP--PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 686
               + GPA   PL    APG  +  PP  G  +            P  A PA     P 
Sbjct: 215 VSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPP 274

Query: 687 PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGG 746
           P+P T        AG       P  A     P  A Q              A A  A   
Sbjct: 275 PAPATLARPPGHPAG-------PPTAAPAVPPPAAAQNGGS----------AGAAPAPAP 317

Query: 747 SGGGPGGAEGGGVTGGARAA 766
           + GGP G  G    G A AA
Sbjct: 318 AAGGPAGVSGQPGPGAAAAA 337



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 128/582 (21%), Positives = 179/582 (30%), Gaps = 137/582 (23%)

Query: 10  AGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGA--AGAVGRKPL-AERAGGIG 66
           A AAA  P   AP  L  RPPG P  PP   PA      A   G+ G  P  A  AGG  
Sbjct: 265 APAAAPPPPPPAPATLA-RPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPA 323

Query: 67  GAT-----------------------IPESAPRAGPTRTSRPPASGRGERA--PPAKNTS 101
           G +                       + ++AP A  T  +  PAS        P  +   
Sbjct: 324 GVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGAL 383

Query: 102 PGPVSSPGRASGTTRPGPLGQ----------------KGLRISAEETVARGKATEAPKRS 145
           P P + P  A GT    P G                  G+R +   TV   +  + P+  
Sbjct: 384 PSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNP 443

Query: 146 ALSAGAR--------RDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 197
                 +        R  +G     P  A+A+    A  +   P+   + RP  PT  P 
Sbjct: 444 TNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQ---PQTTMAPRPATPTSAPP 500

Query: 198 KSVSS----------------------ASEHSTTEPSPAARRRPSAG-----GGLQRPAS 230
             +S+                      +   +T +PS   +R P        GG  + AS
Sbjct: 501 VQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTAS 560

Query: 231 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPK--------------GLQALRPP-- 274
              +++A    +P R+ P A  T  A     +   K              G Q+      
Sbjct: 561 LG-TATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAAN 619

Query: 275 ------QVTPPRKDAAPALGPLSSSPLATPSPSAPP------------SPSAPPSLQTLP 316
                  +   + +A      L     ++P P   P            +P +   +Q   
Sbjct: 620 VKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQ 679

Query: 317 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALAL-PPLQAPPSPPAS 375
             P  P SQATT+L +  L +  S   +   +         PP L+L  P Q        
Sbjct: 680 QQPPPPTSQATTALTAVVLSS--SVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQ 737

Query: 376 PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 435
           P  +PL    P  P AL          PP     Q P      P      T P Q    +
Sbjct: 738 P--TPLVIQQPPKPGAL--------IRPPQVTLTQTPMVALRQPHNRIMLTTPQQ----I 783

Query: 436 AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 477
              PLQ  P P   P + P            AA      K P
Sbjct: 784 QLNPLQ--PVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEP 823



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 59/184 (32%), Positives = 64/184 (34%), Gaps = 33/184 (17%)

Query: 590 AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 649
           A H   A  TPE +R   +G  G    S  P     A        GPA P    GAPGA 
Sbjct: 38  AHHHHLAPRTPE-VRAAAAGALGNHVVSGSPAGAAGA--------GPAAPA--EGAPGAA 86

Query: 650 LPWPPATGPGSADGLCTIYETEGPES-------ATPAPGALDPGPSPGTSGGKAAAGAGA 702
            P PP  G     G     +  GP S       A PAP A    P P  S G  A    A
Sbjct: 87  -PEPPPAGRARPGGGGP--QRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAA 143

Query: 703 GASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 762
            A +  P+ A  G        A            LAA  G   G G GPG   G G   G
Sbjct: 144 AAVAAGPEPAPAGPAKPAGPAA------------LAARAGPGPGPGPGPGPGPGPGKPAG 191

Query: 763 ARAA 766
             AA
Sbjct: 192 PGAA 195


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  138 bits (347), Expect = 2e-32
 Identities = 134/432 (31%), Positives = 179/432 (41%), Gaps = 49/432 (11%)

Query: 180 LPRPAP--SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 237
           LP P P   A P PP   P  S  ++S         +A       G   R  ++    SA
Sbjct: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70

Query: 238 TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP-RKDAAPALGPLSSSPLA 296
             + S   +     G+       + P    L A   P + P  ++D A   G     P +
Sbjct: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG--GKTGQGPGS 128

Query: 297 -TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 355
             PSP  P    + P +     PPA+P       LG+ T +A  +   +PP   +  PPP
Sbjct: 129 RAPSPRLPNKTISGPLI-----PPASP------RLGN-TSEAHGAARTAPPRPNVPAPPP 176

Query: 356 QAPPALALPPLQAPPSPPASPPLSPLATP-SPQAPNALAVHLLQAPFSPPPSPPVQAPFS 414
             PP    PP   PP P +SP  +PL +P  P     L V     P +PPP PP      
Sbjct: 177 PTPPPP--PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP---- 230

Query: 415 PPASPPVSPSATPPSQA-PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473
           PP  PP+ P++    +A  P LA  PL +PP PP  P + P   P  +A P   A P Q 
Sbjct: 231 PPTPPPLPPASVLSDKAVKPQLA--PLHLPPIPPPLPLLPPCGYPGLKAEP---ASPAQD 285

Query: 474 AK----PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA- 528
           A+    PPP  PP  +  P  +LP+PP   PG    S S + P  P  +P  QAPP  A 
Sbjct: 286 AQEPPAPPPPLPPYASCSPRASLPAPP--LPGVN--SSSETPPPLPPKSPSFQAPPQKAG 341

Query: 529 APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD 588
           A  L  PP+PP S      +R   PG       P         PP PP+RSP++ LS   
Sbjct: 342 AQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNP---------PPAPPARSPTTELSSKS 392

Query: 589 LAGHSSSATSTP 600
               + + T  P
Sbjct: 393 QQATAWTPTQQP 404



 Score =  110 bits (274), Expect = 7e-24
 Identities = 134/451 (29%), Positives = 165/451 (36%), Gaps = 85/451 (18%)

Query: 17  PAARAPGLLTPRPP-GSPRPPPPVTPAA---LRVLGAAGAVGRKP-LAERAGGIGGATIP 71
           P    P L  P PP G+P PPPP  P        L  A   GR   LA+   G     + 
Sbjct: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63

Query: 72  ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE 131
           +   R+ P   S    +  G  +   +  S  P      A G     P GQ+        
Sbjct: 64  QINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-------- 115

Query: 132 TVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMARRSRAAG-TEVGLPRPAPSARP 189
            VA GK  + P   A S      T SGP     SP +   S A G      PRP   A P
Sbjct: 116 DVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPA-P 174

Query: 190 RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS 249
            PPT  P              P P     PS+            S   TPL SP   GP 
Sbjct: 175 PPPTPPP-------------PPPPLPPPLPSS------------SPIKTPLVSP--PGPL 207

Query: 250 ARG-----TPRAPAHPSQPKPKGLQALRPPQVTPP---------RKDAAPALGPLSSSPL 295
            +G      P  P  P  P P       PP  TPP          K   P L PL   P+
Sbjct: 208 TKGNLPVVAPPVPCAPPPPPP-------PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI 260

Query: 296 ATPSPSAPP--------SPSAP-PSLQTLPSPPATPPSQAT----TSLGSPTLQATHSFL 342
             P P  PP         P++P    Q  P+PP   P  A+     SL +P L   +S  
Sbjct: 261 PPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSS 320

Query: 343 PSPPLSPLATPPPQAPPALA-LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401
            +PP  P  +P  QAPP  A    L APP+PP S P   L       P A    L     
Sbjct: 321 ETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF--LQKKRHGRPGAGGGKL----- 373

Query: 402 SPPPSPPVQAPFSPPASPPVSPSATPPSQAP 432
           +PPP+PP ++P +  +S     +A  P+Q P
Sbjct: 374 NPPPAPPARSPTTELSSKSQQATAWTPTQQP 404



 Score =  104 bits (259), Expect = 4e-22
 Identities = 114/401 (28%), Positives = 146/401 (36%), Gaps = 101/401 (25%)

Query: 342 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ--- 398
           +P PP  P   PPP  PP L  PP   P +PP S   S L    P+  +AL   + Q   
Sbjct: 1   MPVPPPPPPPLPPP--PPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58

Query: 399 ----------------------------APFSPPPSPPVQAPFSPPASPPVSPSAT---- 426
                                       A      +PP          P + P+      
Sbjct: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118

Query: 427 -------PPSQAP-PSLAAPPLQVPPSPPASPPMSPSA-------TPPPQAPPPLAAPPL 471
                  P S+AP P L    +  P  PPASP +  ++       T PP+   P   PP 
Sbjct: 119 GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT 178

Query: 472 QLAKPPPQAPPALATPPLQA-LPSPP-----ASFPGQAPFSPSASLPMSPLATPPPQAPP 525
               PPP  PP  ++ P++  L SPP      + P  AP  P A  P  P   PPP  PP
Sbjct: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCA--PPPPPPPPPPTPPP 236

Query: 526 VLAAPL------------LQVPPSPPASPTLQAPRRPPT--PGPDTSVSGPRLTLALAPG 571
           +  A +            L +PP PP  P L     PP   PG     + P       P 
Sbjct: 237 LPPASVLSDKAVKPQLAPLHLPPIPPPLPLL-----PPCGYPGLKAEPASPAQDAQEPPA 291

Query: 572 PPPP----PSRSPSSTLSGPDLAGHSSSATS---TPEELRGYDSGPE-GGAAASPPPDAE 623
           PPPP     S SP ++L  P L G +SS+ +    P +   + + P+  GA A P P   
Sbjct: 292 PPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP--- 348

Query: 624 LAACHPAAWSRGPAPPLAFRGAPGA------PLPWPPATGP 658
                PA     P       G PGA      P P PPA  P
Sbjct: 349 -----PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 97/389 (24%), Positives = 126/389 (32%), Gaps = 111/389 (28%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           +RD A  G   + P +RAP   +PR P      P + PA+ R                  
Sbjct: 114 QRDVA-GGKTGQGPGSRAP---SPRLPNKTISGPLIPPASPR------------------ 151

Query: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
            +G  +    A R  P R + P         PP     P P SSP +    + PGPL + 
Sbjct: 152 -LGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKG 210

Query: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 183
            L + A                            P P  P P               P P
Sbjct: 211 NLPVVAP---------------------------PVPCAPPPPP-------------PPP 230

Query: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
            P+  P PP        +S       +P  A    P     L             PL  P
Sbjct: 231 PPTPPPLPP--------ASVLSDKAVKPQLAPLHLPPIPPPL-------------PLLPP 269

Query: 244 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAP 303
               P  +  P +PA  +Q  P       PP   PP    +P      +S  A P P   
Sbjct: 270 C-GYPGLKAEPASPAQDAQEPP------APPPPLPPYASCSP-----RASLPAPPLPGVN 317

Query: 304 PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ----APP 359
            S   PP     P PP +P  QA      P  +A    LP+PP  P + P  Q      P
Sbjct: 318 SSSETPP-----PLPPKSPSFQA------PPQKAGAQALPAPPAPPGSQPFLQKKRHGRP 366

Query: 360 ALALPPLQAPPSPPASPPLSPLATPSPQA 388
                 L  PP+PPA  P + L++ S QA
Sbjct: 367 GAGGGKLNPPPAPPARSPTTELSSKSQQA 395



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 106/416 (25%), Positives = 138/416 (33%), Gaps = 131/416 (31%)

Query: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL---------- 484
           +  PP   PP PP  PP+     PPP A PP++     L +  P+   AL          
Sbjct: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSA-PPVSTDTSSLRRADPKGRSALLADIQQGTRL 59

Query: 485 ---------ATPPLQA----------------LPSPP-------ASFP------------ 500
                    + P +++                  +PP         FP            
Sbjct: 60  RKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG 119

Query: 501 ---GQAPFS--PSASLPMSPLATP--PPQAPPV-----------LAAPLLQVPPSPPASP 542
              GQ P S  PS  LP   ++ P  PP +P +            A P   VP  PP +P
Sbjct: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179

Query: 543 TLQAPRRPP--------------TPGPDTS----VSGPRLTLALAPGPPPPPSR----SP 580
               P  PP               PGP T     V  P +  A  P PPPPP       P
Sbjct: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239

Query: 581 SSTLSG----PDLAGHSSSATSTPEEL------RGYDSGPEGGA------AASPPPDAEL 624
           +S LS     P LA         P  L       G  + P   A       A PPP    
Sbjct: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY 299

Query: 625 AACHPAAWSRGPAPPL-AFRGAPGAPLPWPPAT----GPGSADGLCTIYETEGPESATP- 678
           A+C P A    PAPPL     +   P P PP +     P    G   +     P  + P 
Sbjct: 300 ASCSPRA--SLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF 357

Query: 679 -------APGA----LDPGPS-PGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL 722
                   PGA    L+P P+ P  S     +     A++ +P Q   G+L  G+L
Sbjct: 358 LQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSL 413


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score =  137 bits (346), Expect = 3e-32
 Identities = 189/603 (31%), Positives = 239/603 (39%), Gaps = 84/603 (13%)

Query: 13   AARTPAARAPGLLTPRPPGSP-RPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP 71
            A R P++  P +L PRP  +P R P P    A   +     V  +PL +         + 
Sbjct: 1330 APRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLV--RPLLKLVHS-PSPEVS 1386

Query: 72   ESAPRAGPTRTSRP---PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128
             SAP A P   S P   P+S  G  + P    +  P++SP     +T   PL    L IS
Sbjct: 1387 ASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASP---VSSTVSVPL-SSSLPIS 1442

Query: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMARRSRAAGTEVGLPRPAPSA 187
               T+       AP    +SA      SGP   T  +P +A              P   A
Sbjct: 1443 VPTTLP--APASAPLTIPISAPLTVSASGPALLTSVTPPLA--------------PVVPA 1486

Query: 188  RPRPPTEGPRKSVSSASEHS---TTEPSPAARRRPSAGGGLQRPASR--SLSSSATPLSS 242
             P PP+  P  +  SAS  +    T PS ++ + P     L   +S    L+S+  P  S
Sbjct: 1487 APGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACS 1546

Query: 243  PARSGPSARGTPRAPAHPSQPKPKGLQA--LRPPQ------VTPPRKDAAP---ALGPLS 291
            P     SA  +P     PS P P   QA  L P         TP    AAP    L P  
Sbjct: 1547 PVLVPASALASP----FPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSP 1602

Query: 292  SSPLATPSPSAPPSPSAPPSLQT--LPSPPATPPSQATTSLGS--------PTL--QATH 339
            + PLA P P   PSP A P L +   P P   P S   TSL S        P L   +T 
Sbjct: 1603 APPLA-PLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQ 1661

Query: 340  SFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS-PLATPSPQAPNALAVHLLQ 398
            + LP+P  SPL  P P +   LAL P  AP    +SP  +  L T +PQ P       L 
Sbjct: 1662 TMLPAPVPSPL--PSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLT 1719

Query: 399  APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 458
               S  P+P      +P   PP+ P+ T  S AP    APPL  P SP    P       
Sbjct: 1720 PASSLVPTPAQTLSLAP--GPPLGPTQT-LSLAP----APPL-APASPVGPAPAHTLTLA 1771

Query: 459  PPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 517
            P  +   L AP  +Q     P   P L     Q L   PAS   Q+P S ++SL +S   
Sbjct: 1772 PASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPAS--TQSPASQASSLVVSASG 1829

Query: 518  TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 577
              P    PV     L V    P + TL++   P  P   TS  GPR         PPPP 
Sbjct: 1830 AAP---LPVTMVSRLPVSKDEPDTLTLRS-GPPSPPSTATSFGGPR-----PRRQPPPPP 1880

Query: 578  RSP 580
            RSP
Sbjct: 1881 RSP 1883



 Score =  130 bits (327), Expect = 5e-30
 Identities = 208/704 (29%), Positives = 271/704 (38%), Gaps = 105/704 (14%)

Query: 31   GSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGR 90
            G PRP          V+    A G+  L  +   +  A I   AP  GPT  S  P+S  
Sbjct: 1229 GQPRP------LQRNVVHLVSAGGQHHLISQPAHV--ALIQAVAPTPGPTPVSVLPSS-- 1278

Query: 91   GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG 150
                 P+   +P  +S P  A+    P  +   G+         R   T  P    L+  
Sbjct: 1279 ----TPSTTPAPTGLSLP-LAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPP---LAPA 1330

Query: 151  ARRDTSG-PTPGTPSPAMARRSRAAGT--EVGLPRPAPS-ARPRPP---TEGPRKSVSSA 203
             R  +SG P    P P +        T      P P P+  RP      +  P  S S+ 
Sbjct: 1331 PRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAP 1390

Query: 204  SEHSTTEPSPAARRRPSAGGGLQRPASRSLS-SSATPLSSPARSGPSARGTPRAPAHPSQ 262
                 T  SP     PS+   L  PAS  +   +++PL+SP  S      T   P   S 
Sbjct: 1391 GAAPLTISSPL--HVPSS---LPGPASSPMPIPNSSPLASPVSS------TVSVPLSSSL 1439

Query: 263  PKPKGLQALRPPQVTPPRKDAAPALGPLS---SSPLATPSPSAPP-----SPSAPPSLQT 314
            P            ++ P    APA  PL+   S+PL T S S P      +P   P +  
Sbjct: 1440 P------------ISVPTTLPAPASAPLTIPISAPL-TVSASGPALLTSVTPPLAPVVPA 1486

Query: 315  LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ---APPALALPPLQAPPS 371
             P PP+  PS A+ S  + TL        +P LS   TP      AP +  +P L +  +
Sbjct: 1487 APGPPSLAPSGASPSASALTL----GLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVA 1542

Query: 372  PPASP---PLSPLATPSPQAPN-ALAVHLLQAPFSPPPSPPVQAPFSPPASPP---VSPS 424
            P  SP   P S LA+P P APN A A   L AP S   S  +  P +P A+P    ++PS
Sbjct: 1543 PACSPVLVPASALASPFPSAPNPAPAQASLLAPAS-SASQALATPLAPMAAPQTAILAPS 1601

Query: 425  ATPPSQAPPSLAAPPLQVP---PSPPASPPMSPSATP--------PPQAPPPLAAPPLQL 473
              PP    P LA  P   P    S    P M+PS+TP        P  AP P+ AP    
Sbjct: 1602 PAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQ 1661

Query: 474  AKPPPQAPPALATP-PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL 532
               P   P  L +P   Q L   PA  P     SPS +L    L T  PQ P       L
Sbjct: 1662 TMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTL---SLGTGNPQGP--FPTQTL 1716

Query: 533  QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR----SPSSTLSGPD 588
             + P+    PT  A      PGP     GP  TL+LAP PP  P+     +P+ TL+   
Sbjct: 1717 SLTPASSLVPT-PAQTLSLAPGPPL---GPTQTLSLAPAPPLAPASPVGPAPAHTLT--- 1769

Query: 589  LAGHSSSAT-STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFRGAP 646
            LA  SSSA+   P  ++     P       P     LA    +  S    A  L    + 
Sbjct: 1770 LAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASG 1829

Query: 647  GAPLPWPPATG-PGSADGLCTIYETEGPESATPAPGALDPGPSP 689
             APLP    +  P S D   T+    GP S  P+      GP P
Sbjct: 1830 AAPLPVTMVSRLPVSKDEPDTLTLRSGPPS-PPSTATSFGGPRP 1872



 Score =  117 bits (294), Expect = 3e-26
 Identities = 174/650 (26%), Positives = 234/650 (36%), Gaps = 149/650 (22%)

Query: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 217
            PTPG P P +   S         P   P++RP  P   P    +S S      PSP    
Sbjct: 1036 PTPG-PVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVL-PSPLG-- 1091

Query: 218  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 277
                  G  RP + +LS                + TP AP   S   P G  +L  P   
Sbjct: 1092 ---VLSGTSRPPTPTLS---------------LKPTPPAPVRLSPAPPPGSSSLLKPLTV 1133

Query: 278  PPRKDAAPALGPLSSSPLATPSPSAPPSPS-APPSLQTLPSPPATPPSQATTSLGSPT-- 334
            PP     PA    +S+  AT + +A P+P+ AP  L   P   A  PS    S+G     
Sbjct: 1134 PPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASL 1193

Query: 335  -----------------LQATHSFLPSPPLSPLATPPPQ--------------------A 357
                             +Q     L    +  LA   P+                     
Sbjct: 1194 AQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQ 1253

Query: 358  PPALALPPLQAPPSPPASPPLSPLATPS-PQAPNALAVHLLQAPFSPPPSPPV------- 409
            P  +AL    AP   P    + P +TPS   AP  L++     P +    PP        
Sbjct: 1254 PAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSL-----PLAANQVPPTMVNNTGV 1308

Query: 410  ------QAPFSP-PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 462
                  QAP       PP++P+  PPS   P++  P   + P    +P +  +  P P  
Sbjct: 1309 VKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMP-- 1366

Query: 463  PPPLAAPPLQLAKPP--------PQAPPALATPPL---QALPSP-------PASFPGQAP 504
             P L  P L+L   P        P A P   + PL    +LP P       P S P  +P
Sbjct: 1367 TPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASP 1426

Query: 505  FSPSASLPMS-------PLATPPPQAPPV---LAAPL--------LQVPPSPPASPTLQA 546
             S + S+P+S       P   P P + P+   ++APL        L    +PP +P + A
Sbjct: 1427 VSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPA 1486

Query: 547  PRRPPTPGPD-TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG 605
               PP+  P   S S   LTL LA  P    S++P   L     + H     ST      
Sbjct: 1487 APGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACS 1546

Query: 606  YDSGPEGGAAASP------PPDAELAACHPA-AWSRGPAPPLAFRGAPG----APLPWPP 654
                P   A ASP      P  A+ +   PA + S+  A PLA   AP     AP P PP
Sbjct: 1547 PVLVP-ASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPP 1605

Query: 655  -------ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAA 697
                   A  PG+A  L +        S TP P  + P  +PGTS   A+
Sbjct: 1606 LAPLPVLAPSPGAAPVLAS--------SQTPVP-VMAPSSTPGTSLASAS 1646



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 123/439 (28%), Positives = 159/439 (36%), Gaps = 78/439 (17%)

Query: 316  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP---PSP 372
            P  P T  S+      + T  A H+ + S   +   T PP+  PA    P  AP   P+P
Sbjct: 2388 PERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTP 2447

Query: 373  PASPPLSPLATPSP-------QAPNA---LAVHLLQAPFSPPPS--PPVQAPFSPPASPP 420
             ++P   P   P P        APN    L VH+L +P  PPPS  PP     SP  +PP
Sbjct: 2448 ASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSP--PPPSQIPPCS---SPACTPP 2502

Query: 421  VSPSATPPSQAPPSLAAPPLQVPPSP----PASPPMSPSATPPPQAPPP--------LAA 468
              P+ TPP    P  A   L  P SP    P S P+S S T  P    P        LA+
Sbjct: 2503 --PACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALAS 2560

Query: 469  P-PLQLAKPPPQAPPALA-TPPLQALPSPPASFP------GQAPFSPSASLPMSPLATPP 520
            P  L+LA        +L+  PP   LP      P         P +PS +L    +    
Sbjct: 2561 PESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQ 2620

Query: 521  PQAPPVLA-------------APL-------LQVPPSPPASPTLQAPRRPPTPGPD---- 556
             Q  P  A              PL       L++PPS  +   LQ P        +    
Sbjct: 2621 EQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEA 2680

Query: 557  -TSVSGPRLTLALAPGPPPPPSRSPSSTLS--GPDLAGHSSSATSTPEELRGYDSG---- 609
             T  S P     L       PS S S+T S  GP  A      TS   E+RG  +G    
Sbjct: 2681 KTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQ 2740

Query: 610  PEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYE 669
            P G       P   +         R        RGA    +P    T   ++ G  ++  
Sbjct: 2741 PPGPKVLRKLPGRLVTVVEEKELVRRRRQQ---RGAASTLVPGVSET--SASPGSPSVRS 2795

Query: 670  TEGPESATPAPGALDPGPS 688
              GPES+ P  G  +  PS
Sbjct: 2796 MSGPESSPPIGGPCEAAPS 2814



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 167/664 (25%), Positives = 232/664 (34%), Gaps = 151/664 (22%)

Query: 209  TEPSPAARRRP--SAGGGLQRPASRSLSSSATPLSSP-ARSGPSARGTPRAPAHPSQPKP 265
            T P P  R +P       + +P  +    +   +++P A  GP     P  P   +QP P
Sbjct: 979  TAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTP 1038

Query: 266  KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQ 325
              +  + P  +      A P L P S  P     P   P+  + P  Q LPSP       
Sbjct: 1039 GPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLP--QVLPSPLGV--LS 1094

Query: 326  ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS---PPASPPLS--- 379
             T+   +PTL    S  P+PP     +P P    +  L PL  PP    PPA+   +   
Sbjct: 1095 GTSRPPTPTL----SLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTT 1150

Query: 380  ---------PLATPSPQ----APNALA-------------VHLLQAPF-----SPPPSPP 408
                     P  TP+PQ    +P+  A               L Q P      S P +  
Sbjct: 1151 TATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQ 1210

Query: 409  VQA-------------------PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
            +Q                    P        VS        + P+  A    V P+P  +
Sbjct: 1211 IQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPT 1270

Query: 450  P-PMSPSATPPPQAPPPLAAPPLQLAKPPP--------------QAPPALAT--PPLQAL 492
            P  + PS+TP     P   + PL   + PP              QAP    T  PPL   
Sbjct: 1271 PVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPA 1330

Query: 493  PSPPAS-FPGQAPFSPSASLPMSPLATP------PPQAPPVLAAPLLQVPPSPPASPTLQ 545
            P PP+S  P  A  +P  +L    L TP       P   P L  PLL++  SP    +  
Sbjct: 1331 PRPPSSGLP--AVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSAS 1388

Query: 546  APRRPPTPGPDTSVSGPRLTLALAPGPP----PPPSRSP-----SSTLSGPDLAGHSSSA 596
            AP   P      ++S P    +  PGP     P P+ SP     SST+S P     SS  
Sbjct: 1389 APGAAP-----LTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVP---LSSSLP 1440

Query: 597  TSTPEELRGYDSGPEGGAAASP---------------PPDAELAACHPAAWSRGP----- 636
             S P  L    S P     ++P               PP A +    P   S  P     
Sbjct: 1441 ISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP 1500

Query: 637  -----------APPLAFRGAPGAPLPWPPATG--PG---SADGLCTIYETEGPESATPAP 680
                       AP L+    PG PL   P +   PG   +    C+         A+P P
Sbjct: 1501 SASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFP 1560

Query: 681  GALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAA 740
             A +P P+  +    A++ + A A+  +P  A     P  A+ A      L+   +LA +
Sbjct: 1561 SAPNPAPAQASLLAPASSASQALATPLAPMAA-----PQTAILAPSPAPPLAPLPVLAPS 1615

Query: 741  EGAA 744
             GAA
Sbjct: 1616 PGAA 1619



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 146/569 (25%), Positives = 195/569 (34%), Gaps = 106/569 (18%)

Query: 12   AAARTPAARAPGLLTP-RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLA-ERAGGIGGAT 69
            +A  T +A  P LLT   PP +P  P    P +L   GA+ +     L    A  +  + 
Sbjct: 1460 SAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQ 1519

Query: 70   IPESAPRAGPTRTSRP---------------PASGRGERAPPAKNTSPG------PVSSP 108
             P       PT +  P               PAS      P A N +P       P SS 
Sbjct: 1520 TPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSA 1579

Query: 109  GRASGTT-RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP------TPG 161
             +A  T   P    Q  +   +           AP   A    A   T  P      TPG
Sbjct: 1580 SQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPG 1639

Query: 162  T------PSPAMARRSRAAGTEVGLPRPAPSARPRP---------PTEGPRKSVSSASEH 206
            T      P PA       + T+  LP P PS  P P         P   P    SS S+ 
Sbjct: 1640 TSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQT 1699

Query: 207  ------STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260
                  +   P P      +    L    +++LS +  P   P ++   A   P APA P
Sbjct: 1700 LSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASP 1759

Query: 261  SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA-TPSPSAPPSPSAPPSLQTLPSPP 319
              P P     L P         +A  L P S   L  +P+P     P+A  +L   P+  
Sbjct: 1760 VGPAPAHTLTLAPAS------SSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPAST 1813

Query: 320  ATPPSQATTSL----GSPTLQATH-SFLP----SPPLSPLATPPPQAPPALALP-----P 365
             +P SQA++ +    G+  L  T  S LP     P    L + PP +PP+ A       P
Sbjct: 1814 QSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPP-SPPSTATSFGGPRP 1872

Query: 366  LQAPPSPPASP-PLSPLATPSPQAPNALAVHLLQ--------AP--------FSPPPSPP 408
             + PP PP SP  L  L     +  +     + Q        AP        F   P P 
Sbjct: 1873 RRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQP- 1931

Query: 409  VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ--------------VPPSPPASPPMSP 454
            V +P  P +  P  P+    ++A       P Q              V P   A PP   
Sbjct: 1932 VASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLH 1991

Query: 455  SATPPPQAPPPLAAPPLQLAKPP-PQAPP 482
            +  PPP   P  AA   QLA    P+A P
Sbjct: 1992 ACHPPPWLAPRQAAFQEQLASELWPRARP 2020



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 183/797 (22%), Positives = 245/797 (30%), Gaps = 183/797 (22%)

Query: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86
            PRP   PRP P   PAA+  L         P+   +       +P     + P  +  PP
Sbjct: 2437 PRPAPRPRPTPASAPAAIPALVPVPVSAPVPI---SAPNPITILPVHILPSPPPPSQIPP 2493

Query: 87   ASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP--LGQKGLRISAE----------ETVA 134
             S      PPA    P     P +    T   P  LG   + ISA           E   
Sbjct: 2494 CSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAEL 2553

Query: 135  RGKATEAPKRSALSAGARRDTS-------------------------GPTPGTPSPAMAR 169
              +A  +P+   L++ A  +TS                           TP  PS  +  
Sbjct: 2554 CAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEA 2613

Query: 170  RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP- 228
             S   G E   P  A         EG    +  +  +    P  AA   P     LQ P 
Sbjct: 2614 GSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEP-----LQEPL 2668

Query: 229  ----ASRSLSSSATPLSSPAR----------------------SGPSARGTPR------- 255
                 S  L+ + TP SSP +                       GPS    PR       
Sbjct: 2669 EADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADV 2728

Query: 256  -----APAHPSQPK-PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAP 309
                     P QP  PK L+ L    VT   +              +T  P    + ++P
Sbjct: 2729 EIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASP 2788

Query: 310  --PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP------------------ 349
              PS++++  P ++PP      +G P   A  S LP+PP  P                  
Sbjct: 2789 GSPSVRSMSGPESSPP------IGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPE 2842

Query: 350  ------LATPPPQAPPALALPPLQAPPSPPA-----SPPLSPL------ATPSPQAPNAL 392
                  LA  PP        PP +      A       P S L      A P P  P  L
Sbjct: 2843 NGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVP-GPETL 2901

Query: 393  AV--HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS-PPAS 449
             V   +L+    P P P    P   P +P +SP        PP   A  L +P +   A 
Sbjct: 2902 IVADPVLEPQLIPGPQPLGPQPVHRP-NPLLSPVEKRRRGRPPK--ARDLPIPGTISSAG 2958

Query: 450  PPMSPSATPPPQAPPPLA-APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
               S S T PP  P PL   PPL +    P A  A     +    SPP    G+ P +P 
Sbjct: 2959 DGNSESRTQPPPHPSPLTPLPPLLVC---PTATVANTVTTVTISTSPPKRKRGRPPKNP- 3014

Query: 509  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568
                     +P P   PVL      V  S       Q   +  + G  +   G R     
Sbjct: 3015 --------PSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGSR----- 3061

Query: 569  APGPPPPPSRSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEG------------ 612
                  P +R     L    + G  S  +       ++L   DSGP G            
Sbjct: 3062 ------PLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTP 3115

Query: 613  --------GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL 664
                      +  PP + E      A    G +P LA RG    P P  P      ++  
Sbjct: 3116 KLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAE 3175

Query: 665  CTIYETEGPESATPAPG 681
             +  E EG  +    PG
Sbjct: 3176 ASGEEEEGDGTPRRRPG 3192



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 108/456 (23%), Positives = 152/456 (33%), Gaps = 65/456 (14%)

Query: 340  SFLPSPPLS-------PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL 392
            +FLP   LS         A  PP  P  + +   +     P     + +   +P+AP   
Sbjct: 962  TFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAP--- 1018

Query: 393  AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452
               L   P  PPP P + A  +P   P V P++   S +P      P   PP P   PP+
Sbjct: 1019 ---LGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPL 1075

Query: 453  SPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP 512
             P++   PQ  P         ++PP        TP L   P+PPA         P +S  
Sbjct: 1076 QPNSGSLPQVLPSPLGVLSGTSRPP--------TPTLSLKPTPPAPVRLSPAPPPGSSSL 1127

Query: 513  MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 572
            + PL  PP    P  AA       +   +  + A    PTP P   +  P +   L  G 
Sbjct: 1128 LKPLTVPPGYTFPPAAATTTSTTTATATTTAVPA----PTPAPQRLILSPDMQARLPSGE 1183

Query: 573  PPPPSRSPSSTLSGPDLAGHS---------SSATSTPEELRGYDSG-------------P 610
                 +  S        AG S         +  T T  ++R    G              
Sbjct: 1184 VVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVS 1243

Query: 611  EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG-PGSAD------- 662
             GG        A +A     A + GP P      +  +  P P     P +A+       
Sbjct: 1244 AGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMV 1303

Query: 663  ---GLCTIYETEGP-ESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 718
               G+  I   + P +  TP P  L P P P +SG  A        +       RL    
Sbjct: 1304 NNTGVVKIVVRQAPRDGLTPVP-PLAPAPRPPSSGLPAVLNPRPTLT-----PGRLPTPT 1357

Query: 719  LGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGA 754
            LG  +A +    L R LL      +   S   PG A
Sbjct: 1358 LGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAA 1393



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 174/720 (24%), Positives = 228/720 (31%), Gaps = 178/720 (24%)

Query: 93   RAPPAKNTSPGP--VSSPGRASGTTRPGPLGQK----GLRISAEETVARGKATEAPKRSA 146
            R P  +   PG    SS G   GT R     +     G R+S     AR +   A     
Sbjct: 2355 RLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPV 2414

Query: 147  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206
            +SA   R T+  TP   SPA  R          +PRPAP  RPRP       ++ +    
Sbjct: 2415 ISAHQTRSTT--TPPRCSPARER----------VPRPAP--RPRPTPASAPAAIPALVPV 2460

Query: 207  STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK-- 264
              + P P +   P     +    S    S   P SSPA + P A   P  PAH   P   
Sbjct: 2461 PVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPP--PAHTPPPAQT 2518

Query: 265  ----PKGLQALRPPQVT-------------PPRKDAAPALGPLSSSPLATPSPSAPPSPS 307
                P     L PP V              P  +  A AL    S  LA+ + S   S S
Sbjct: 2519 CLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLS 2578

Query: 308  APPSLQTLP-SPPATPPSQATTSL--GSPTLQATHSFLPS-----PPLSPLATPPPQAPP 359
              P    LP +    P S+   SL   +P+L      +P+      P S   T     P 
Sbjct: 2579 LVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPE 2638

Query: 360  ALALP-------PLQAPPSPPASPPLS-PLA--------------TPSPQAPNALAVHLL 397
               LP        L+ PPS  +  PL  PL               T SP+ P  L    +
Sbjct: 2639 GEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEV 2698

Query: 398  QAPF---SPPPSPPVQAPFSP------------------PASPP---------------- 420
             AP    S   SP   +P  P                  P  PP                
Sbjct: 2699 AAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVV 2758

Query: 421  -----------------------VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457
                                      SA+P S +  S++ P    P   P     S S  
Sbjct: 2759 EEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLP 2818

Query: 458  PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 517
             PPQ  P +A   ++L      +P       L   P       G+ P             
Sbjct: 2819 TPPQ-QPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPP------------- 2864

Query: 518  TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT-SVSGPRLTLALAPGPP--- 573
                ++P      + + P S     T  A    P PGP+T  V+ P L   L PGP    
Sbjct: 2865 -KKNRSPADAGRGVDEAPSSTLKGKTNGA---DPVPGPETLIVADPVLEPQLIPGPQPLG 2920

Query: 574  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAAS---PPPDAELAACHPA 630
            P P   P+  LS  +         +    + G  S    G + S   PPP       HP+
Sbjct: 2921 PQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPP-------HPS 2973

Query: 631  AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTI-YETEGPESATPAPGALDPGPSP 689
              +  P PPL         L  P AT    A+ + T+   T  P+     P    P P P
Sbjct: 2974 PLT--PLPPL---------LVCPTAT---VANTVTTVTISTSPPKRKRGRPPKNPPSPRP 3019


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score =  135 bits (339), Expect = 2e-31
 Identities = 225/779 (28%), Positives = 267/779 (34%), Gaps = 150/779 (19%)

Query: 17  PAARAPGLLTPRPP-----GSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP 71
           P+AR P  + P  P     GS  P PP    A   L   G +    LA+     GG++ P
Sbjct: 143 PSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPS-GGSSSP 201

Query: 72  ESAPRAGPTRTSRPPASGRGERA--------------------PPAKNTSPGPVSSPG-- 109
              PR      + PP       A                    PPA + S  P S P   
Sbjct: 202 RFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLF 261

Query: 110 RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL--------SAGARRDTSGPTPG 161
             S    P PL       S       G A++ P  SA           G      G  PG
Sbjct: 262 HCSDALTPPPLPP-----SNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEG--PG 314

Query: 162 TPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA 221
            P    +    AA      P P PS         PR    SAS  S+  PS    RRP  
Sbjct: 315 APPFLASSLLSAAAKAQHPPLPPPSTL---QGRRPRAQAPSASHSSSLRPSQRRPRRP-- 369

Query: 222 GGGLQRPASRSLSSSATPLSSPARSGPSARG---TPRAPAHPSQP-KPKGLQALRPPQVT 277
                 P    L     P  +P RS P A      P +   PSQP  P  L  L  P   
Sbjct: 370 ------PTVFRLLEGRGP-QTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPG 422

Query: 278 PPRKDAAPAL--------GPLSSSPLATPSPSAPPSPSAP----PSLQTLPSPPATPPSQ 325
           P   D +  L         P + S  + P P  P  PS P     SL ++P  PA P + 
Sbjct: 423 PSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAAS 482

Query: 326 ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 385
               + SP LQ+     PS  L         A PA  LPPL    + P   P   LA   
Sbjct: 483 KAPVVPSPVLQS-----PSEGLG------MGAGPACPLPPLAGGEAFPFPSPEQGLALSG 531

Query: 386 PQAPNALAVHLLQAPFS---PPPSPPVQAPF-----SPPASPPVSPSATPPSQAPPSLAA 437
              P  L    L  P S   PPPSP +              PP  P   PP    P LA 
Sbjct: 532 AGFPGMLGA--LPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLA- 588

Query: 438 PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA---LATPPLQAL-- 492
                 P  P  P +  ++  PP        PP  L  PPP APP+    +  PL AL  
Sbjct: 589 ------PGEPEGPSLLVASLLPP--------PPSDLL-PPPSAPPSNLLASFLPLLALGP 633

Query: 493 -------PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA---PLLQV---PPS-- 537
                   +  A  P   PFS    L  SPL  PP  APP L A    LL     PPS  
Sbjct: 634 TAGDGEGSAEGAGGPSGEPFSGLGDL--SPLLFPPLSAPPTLIALNSALLAATLDPPSGT 691

Query: 538 PPASPTLQAPR-RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS---GPDLAGHS 593
           PP    L AP+  PPT    T+ + P    A + G  P  S  P   LS   G  L G  
Sbjct: 692 PPQPCVLSAPQPGPPTSSVTTATTDPG---ASSLGKAPSNSGRPPQLLSPLLGASLLGDL 748

Query: 594 SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWP 653
           SS TS+P  L      P  G   S     +L          G  PPL+   +P A L   
Sbjct: 749 SSLTSSPGALPSLLQPP--GPLLSGQLGLQLLP------GGGAPPPLSEASSPLACLLQS 800

Query: 654 PATGPGSADGLCTIYETEG----PESATPAPGAL-DPGPSPGTSGGKAAAGAGAGASSR 707
               P   +  C   E+      PE A P   AL  P  SP     +   G G+G   R
Sbjct: 801 LQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGR 859



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 141/483 (29%), Positives = 179/483 (37%), Gaps = 84/483 (17%)

Query: 316 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLS--PLATPPPQAPPALALPPLQAPPSPP 373
           P   A+P    T S G P+ +      P+ PL+  P + PP     + A P L  P    
Sbjct: 126 PGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGG-- 183

Query: 374 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS-----ATPP 428
             PP   LA P P   ++         F P  + P  AP  PPA    +PS     A   
Sbjct: 184 LFPP--RLADPVPSGGSS------SPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRS 235

Query: 429 SQAPPSLAAPPL-QVPPSPPASPPM---SPSATPPPQAPP-PLAAPPLQLAKPPPQAPPA 483
           S  P  L +PP      SPP+ PP+   S + TPPP  P   L A P   ++PP  +  A
Sbjct: 236 SLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSS--A 293

Query: 484 LATPPLQALP---SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVL---AAPLLQVPPS 537
               PL   P   +P    PG  PF  S+ L  +  A  PP  PP       P  Q P +
Sbjct: 294 TMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSA 353

Query: 538 PPAS---PTLQAPRRPPT-------PGPDTSVSGPRLTLALAPGPPPPPSRSPS------ 581
             +S   P+ + PRRPPT        GP T    PR +   AP P P P   P       
Sbjct: 354 SHSSSLRPSQRRPRRPPTVFRLLEGRGPQT----PRRSRPRAPAPVPQPFSLPEPSQPIL 409

Query: 582 -STLSGPDLAGHSSSATSTPEELRGYDS----GPEGGAAASPPPDAELAACHPAAWS--- 633
            S LS   L     S +     L G D+     P   + + P P   +    P   S   
Sbjct: 410 PSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSL 469

Query: 634 ----RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689
                 PAPP A + AP  P P   +   G   G        GP    P     +  P P
Sbjct: 470 SSVPGAPAPPAASK-APVVPSPVLQSPSEGLGMG-------AGPACPLPPLAGGEAFPFP 521

Query: 690 GTSGGKAAAGAGAGASSRSPKQARLGELPLG-ALQASVVQHLLSRTLLLAAAEGAAGGSG 748
               G A +GAG            LG LPL  +L       LL+ +L      G   G G
Sbjct: 522 SPEQGLALSGAGF--------PGMLGALPLPLSLGQPPPSPLLNHSLF-----GVLTGGG 568

Query: 749 GGP 751
           G P
Sbjct: 569 GQP 571



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 70/271 (25%), Positives = 94/271 (34%), Gaps = 61/271 (22%)

Query: 21  APGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG----GATIPESAPR 76
           +PG L    P   +PP P+    L +    G     PL+E +  +        IP   P 
Sbjct: 754 SPGAL----PSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPE 809

Query: 77  AGPTRTSRPPASGRGERAPPAKNTSPGPVSSP---------GRASGTTRPGPLGQKGLR- 126
           A       P ++   E A P  +    P  SP         GR SG  + G  G  GLR 
Sbjct: 810 APCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSG--KRGRRGGGGLRG 867

Query: 127 ISAEETVARGK---ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL--- 180
           I+ E   ARG+   +   P R AL  G R   +G    +P      +      E G    
Sbjct: 868 INGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPK 927

Query: 181 --PRPAP--------------SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 224
             P P P              S R R     P ++ +S+ +  T EPSP AR        
Sbjct: 928 DPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTAR-------- 979

Query: 225 LQRPASRSLSSSATPLSSPARSGPSARGTPR 255
                      +A PL   AR G  A+   R
Sbjct: 980 -----------AAVPLPPRARPGRPAKNKRR 999



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 38/149 (25%), Positives = 50/149 (33%), Gaps = 12/149 (8%)

Query: 568 LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD---SGPEGGAAASPPPDAEL 624
           LAP  P      P+S      L  H   A +     R  +   S    G  ASP     +
Sbjct: 79  LAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTV 138

Query: 625 AACHPAAWSRGPAPPLA-FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683
           +   P+A      PP     G PG+  P PP+                GP    P P   
Sbjct: 139 SPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPT-------LAGPGGLFP-PRLA 190

Query: 684 DPGPSPGTSGGKAAAGAGAGASSRSPKQA 712
           DP PS G+S  +      A + +  P  A
Sbjct: 191 DPVPSGGSSSPRFLPRGNAPSPAPPPPPA 219


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  134 bits (337), Expect = 3e-31
 Identities = 198/726 (27%), Positives = 249/726 (34%), Gaps = 132/726 (18%)

Query: 22  PGLLTPRPPGSPRPPPPVTPAALR-------------VLGAAGAVGRKPLAERAGGIGGA 68
           P  L P PP  P PPPP+   A               + G A    RK  A         
Sbjct: 248 PPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRH 307

Query: 69  TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128
           ++P   P   P  T+ PP       APP     P    S G    T  PG      LR  
Sbjct: 308 SLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPG----SDLR-- 361

Query: 129 AEETVARGKATEAPKRSALSAGARRDTSGPT--PGTPSPAMARRSRAAGTEVGLPRPAPS 186
            E  V R +   +   +A +A      S P   PGT + + +  S   G     P P   
Sbjct: 362 -ESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGI- 419

Query: 187 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP-LSSPAR 245
               P  +  +      S H    PS  + R+P  G           + +ATP LS P  
Sbjct: 420 ----PGADHYQTPALEVSHHGRLGPSAHSSRKPFLG-----------APAATPHLSLPP- 463

Query: 246 SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPS 305
            GPS+   P  P     P P     L+ P     R+D    L  L       P P+ PP 
Sbjct: 464 -GPSSPPPPPCPRLLRPPPPPAW--LKGPACRAAREDGE-ILEELFFGTEGPPRPAPPPL 519

Query: 306 PS-----APP----SLQTLPS-PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 355
           P       PP    S+ T  S  P TPP+  T+S  S +   +HS   S P  P++ PPP
Sbjct: 520 PHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNS--GSHS---SSPAGPVSFPPP 574

Query: 356 QAPPALA--LPPLQAPPSP---PASPPLSPLATPSPQAPNALAVHLLQAPFSPP--PSPP 408
              P LA  + PL  PPSP   P  PPL PL    P AP +         F  P  P P 
Sbjct: 575 ---PYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPR 631

Query: 409 VQAPFSPPASP--PVSPSATPPSQAPPSLAAPPLQVP---PSPPASPPMSPSATPPPQ-- 461
           V  P +P   P  P  P +  P   PP +   P + P     PP   P+      P +  
Sbjct: 632 VSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPT--PLEDQFEEPAEFK 689

Query: 462 -APPPLAAPPLQL----AKPPPQAPPALATPPLQALPSPPASFPGQAPF----SPSASLP 512
             P  LA     L     K   Q        P   L  P AS   Q+PF    +P+ + P
Sbjct: 690 ILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASL--QSPFPTDTAPTTTAP 747

Query: 513 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 572
              + T         A    +  P P   P     + PP   P              P P
Sbjct: 748 AVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQ-------------PPP 794

Query: 573 PPPPS-----RSPSSTLSGPDLA----GHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 623
           PPPPS     +S +S L G        G + S    P     Y  GP  GA A PP  A 
Sbjct: 795 PPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSA- 853

Query: 624 LAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683
                        AP      A G+P P   ++   S  G     E    E   P PG +
Sbjct: 854 -------------AP-----SAQGSPQPSASSSSQFSTSGGPWARERRAGEE--PVPGPM 893

Query: 684 DPGPSP 689
            P   P
Sbjct: 894 TPTQPP 899



 Score =  107 bits (266), Expect = 6e-23
 Identities = 176/681 (25%), Positives = 232/681 (34%), Gaps = 131/681 (19%)

Query: 137 KATEAPKRSALSAGARRDTSGPTPGTPSPAMAR--RSRAAGTEVGLPRPA----PSARPR 190
           +A E P    +   A    SG    +P     R   S   G   GLP P     P   P 
Sbjct: 199 RAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPP 258

Query: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG-------GLQRPASRSLSSSATPLSSP 243
           PP   P   ++++     T+P   +     A G         +R   R       P  +P
Sbjct: 259 PPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAP 318

Query: 244 ARSG--PSARGTPRAPAHPSQPKPKG------LQALRPPQVTPPRKDAAPALGPLSSSPL 295
           A +   P  R  P AP  P  P+P G      L A RPP           +    S SP 
Sbjct: 319 AYTAHPPGHRLVPAAPPGPG-PRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPA 377

Query: 296 ATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLG--------------SPTLQATHSF 341
           AT +   P +PS PP L    +  ++  S  T   G              +P L+ +H  
Sbjct: 378 AT-TACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHG 436

Query: 342 LPSPPLSPLATP---PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQA----PNALAV 394
              P       P    P A P L+LPP  + P PP  P L  L  P P A    P   A 
Sbjct: 437 RLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRL--LRPPPPPAWLKGPACRAA 494

Query: 395 ----HLLQAPF---------SPPPSPPVQAPFSPPAS-----------PPVSPSATPPSQ 430
                +L+  F         +PPP P  +    PPAS           PP  P+ T  S 
Sbjct: 495 REDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSS 554

Query: 431 -----APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP--PLQLAKPPPQAPPA 483
                +  S  A P+  PP P  +  + P   PP  A  P   P  PL LA PP      
Sbjct: 555 NSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPP------ 608

Query: 484 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 543
              PP     +   SF       P  S P +P   P P   P+  AP   VPP     P 
Sbjct: 609 --APPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAP-QPVPPGVGELPA 665

Query: 544 LQAPRR---PPTPGPDTSVSGPRLTLALAPG-------------------------PPPP 575
            + PR    PPTP  D     P     L  G                          P P
Sbjct: 666 -RGPRLFDFPPTPLED-QFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQP 723

Query: 576 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRG 635
           P + P ++L  P     ++  T+ P       +       A+   + +     P      
Sbjct: 724 PLKEPFASLQSP-FPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALP------ 776

Query: 636 PAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYET-EGPE---SATPAPGALDPGPSPGT 691
           P PPLA    P  P P PP   P  A  L ++    EG +     T A  +  PGP P T
Sbjct: 777 PPPPLAKFPPPSQPQP-PPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTT 835

Query: 692 SGGKAAAGAGAGASSRSPKQA 712
              + + G  +GA++  P  A
Sbjct: 836 ---QYSPGPPSGATALPPTSA 853



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 187/707 (26%), Positives = 233/707 (32%), Gaps = 102/707 (14%)

Query: 11   GAAARTP-AARAPGLLTPRPPGSP---RPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66
            GA A TP  +  PG  +P PP  P   RPPPP  PA L           K  A RA    
Sbjct: 451  GAPAATPHLSLPPGPSSPPPPPCPRLLRPPPP--PAWL-----------KGPACRAARED 497

Query: 67   GATIPE-SAPRAGPTRTSRPPASGR-GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124
            G  + E      GP R + PP   R G   PPA   S G   S    +  T P P     
Sbjct: 498  GEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDS---HTPPTPPTPTTSSS 554

Query: 125  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 184
               S   + +       P    L+      +  P P  PSPA   +       V L    
Sbjct: 555  NSNSGSHSSSPAGPVSFPPPPYLAR-----SIDPLPRPPSPAQNPQDPPL---VPLTLAL 606

Query: 185  PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL---- 240
            P   P PP+   + +  S     +  P  +  + P  G G   P    LS +  P+    
Sbjct: 607  P---PAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPG---PPPGPLSKAPQPVPPGV 660

Query: 241  -SSPARSGPSARGTPRAP-----AHPSQPK--PKGL---QALRPPQVTPPRKDAAPALGP 289
               PAR GP     P  P       P++ K  P GL     +    +    +      G 
Sbjct: 661  GELPAR-GPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGV 719

Query: 290  LSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349
                PL  P  S      +P    T P+  A   +  TT+  + T  AT      P   P
Sbjct: 720  APQPPLKEPFASL----QSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKP---P 772

Query: 350  LATPPPQAPPALALPP---LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS 406
             A PPP  PP    PP    Q PP PP SP     +  S             A  S  P 
Sbjct: 773  PALPPP--PPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPG 830

Query: 407  PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 466
            P     +SP   PP   +A PP+      AAP  Q  P P AS     S +  P A    
Sbjct: 831  PLPTTQYSP--GPPSGATALPPTS-----AAPSAQGSPQPSASSSSQFSTSGGPWARERR 883

Query: 467  AA-PPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAP-----FSPSASLPMSPLAT-- 518
            A   P+     P Q PP L+ PP ++                     SA+ P  P+ T  
Sbjct: 884  AGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAE 943

Query: 519  ----------PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568
                      PP QA                     Q   R        SV G R     
Sbjct: 944  PADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSV-GRRPREGR 1002

Query: 569  APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD-SGPE-GGAAASPPPDAELAA 626
            A      P       L   DL           EE++G + S P+ GGA+ + PP A    
Sbjct: 1003 AKAKAKVPKEKSRRVLGNLDLQS---------EEIQGREKSRPDLGGASKAKPPTAPAPP 1053

Query: 627  CHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP 673
              PA  S  P PP A      A    P   G   AD L     +EGP
Sbjct: 1054 SAPAP-SAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGP 1099



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 133/528 (25%), Positives = 163/528 (30%), Gaps = 99/528 (18%)

Query: 245 RSGPSARGTPRAPAHPSQPK-----PKGLQALRPP----QVTPPRKDAAPALGPLSSSPL 295
           R GP  +     P     P      P G + L P     +     +   P   PL   PL
Sbjct: 192 RGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPL 251

Query: 296 ATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGS-----------PTLQATHSFLPS 344
             P P  PP P   P L T P    T P   +T  G            P  Q     LP 
Sbjct: 252 PPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPH 311

Query: 345 PPLSPLATPPPQA-PPALALPPLQAPPSPPASPP------LSPLATP------------- 384
           P   P   P   A PP   L P  APP P   PP        P   P             
Sbjct: 312 P--YPYPAPAYTAHPPGHRLVP-AAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRS 368

Query: 385 ---SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS---LAAP 438
              S  +P A    +  AP  PP  P      S  +S         P+   P       P
Sbjct: 369 RMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTP 428

Query: 439 PLQVPPSPPASPPMSPSATP---PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSP 495
            L+V       P    S  P    P A P L+ PP   + PPP  P  L  PP  A    
Sbjct: 429 ALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKG 488

Query: 496 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 555
           PA    +        L       P P  PP+        PP+   S   Q    PPT   
Sbjct: 489 PACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPT--- 545

Query: 556 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA 615
                            PP P+ S S++ SG     HSSS                 G  
Sbjct: 546 -----------------PPTPTTSSSNSNSG----SHSSS---------------PAGPV 569

Query: 616 ASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPL-----PWPPATGPGSADGLCTIYET 670
           + PPP     +  P    R P+P    +  P  PL     P PP++   +  G     E+
Sbjct: 570 SFPPPPYLARSIDPL--PRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPES 627

Query: 671 EGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 718
             P  + P    + PGP PG    KA      G      +  RL + P
Sbjct: 628 PRPRVSFPKTPEVGPGPPPGPL-SKAPQPVPPGVGELPARGPRLFDFP 674



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 129/559 (23%), Positives = 179/559 (32%), Gaps = 105/559 (18%)

Query: 27   PRPPGSPRPP--PPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSR 84
            PRPP   + P  PP+ P  L +  A                     P S+     + + R
Sbjct: 585  PRPPSPAQNPQDPPLVPLTLALPPA---------------------PPSSCHQNTSGSFR 623

Query: 85   PPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG-KATEAPK 143
             P S R   + P K    GP   PG  S   +P P G         E  ARG +  + P 
Sbjct: 624  RPESPRPRVSFP-KTPEVGPGPPPGPLSKAPQPVPPG-------VGELPARGPRLFDFPP 675

Query: 144  RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 203
                            P   +  M     +   E    +      P+PP + P  S+ S 
Sbjct: 676  TPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSP 735

Query: 204  --SEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 261
              ++ + T  +PA     +        A++       P   P    P A+  P +   P 
Sbjct: 736  FPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPP--PLAKFPPPSQPQPP 793

Query: 262  QPKP-------KGLQALRPPQVTPPRKDAAPAL---GPLSSSPLATPSPS---APPSPSA 308
             P P       K L ++   Q    R   A      GPL ++  +   PS   A P  SA
Sbjct: 794  PPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSA 853

Query: 309  PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP-PLSPLATPPPQA-PPAL----- 361
             PS Q  P P A+  SQ +TS G    +      P P P++P   PPP + PPA      
Sbjct: 854  APSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEV 913

Query: 362  ------ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP 415
                  A   L       A+ P  P+ T  P   ++    LL         PP QA    
Sbjct: 914  LEEISRACETLVERVGRSATDPADPVDTAEPA--DSGTERLL---------PPAQAKEEA 962

Query: 416  PASPPVSPSATPPSQ------------APPSLAAPPLQVPPSPPASPPMSPSA------- 456
                 VS S     +               S+   P +      A  P   S        
Sbjct: 963  GGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLD 1022

Query: 457  -----------TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA--SFPGQA 503
                       + P       A PP   A P   AP A  TPP  ++P   A    PG  
Sbjct: 1023 LQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPP 1082

Query: 504  PFSPSASLPMSPLATPPPQ 522
              S +  L +  L+  PP+
Sbjct: 1083 GVSRADMLKLRSLSEGPPK 1101


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  134 bits (337), Expect = 3e-31
 Identities = 181/640 (28%), Positives = 230/640 (35%), Gaps = 140/640 (21%)

Query: 56  KPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 115
           KP+ E   G+ G     +    G   T R   SGR ++ P + +    P++   R+SG  
Sbjct: 3   KPVKEEDDGLSGKHSMRTRRSRGSMSTLR---SGR-KKQPASPDGRTSPINEDIRSSGRN 58

Query: 116 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPAMARRSR 172
            P          SA  T +     E  K+SA     + + S P            +    
Sbjct: 59  SP----------SAASTSSNDSKAETVKKSAKKV--KEEASSPLKSNKRQREKVASDTEE 106

Query: 173 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH-----------------STTEPSPAA 215
           A  T     +    +RP  P+EG  +S  S S +                 S + PSP  
Sbjct: 107 ADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQD 166

Query: 216 RRRPSAGGGLQR-----PASRSLSSSATPLSSPARSG----PSARGTPRAPAHPSQPKPK 266
               S     Q+     P +    +  TP  S A  G    P+   TP A A P Q  P 
Sbjct: 167 NESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPT 226

Query: 267 GLQALRPPQV-TPP----RKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL------ 315
             QA   PQ  T P        APAL      P   PSP  PP PS  P LQ L      
Sbjct: 227 ASQAPNQPQAPTAPVPHTHIQQAPAL-----HPQRPPSPHPPPHPSPHPPLQPLTGSAGQ 281

Query: 316 PSPP--ATPPSQATTSLGSPTLQATHSFL-PSPPL------------SPLATPPPQA--- 357
           PS P  A PP       G  +LQA      P PP             +PL T P  A   
Sbjct: 282 PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPH 341

Query: 358 -----------------------PPA-LALPPLQAPPSPPASPPLSPLATPSPQAPNALA 393
                                  PPA LA+P ++ PP+ P  P L     P+PQA     
Sbjct: 342 TSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPI-PQL-----PAPQAHKHPP 395

Query: 394 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASP 450
                +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA P
Sbjct: 396 HLSGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQP 450

Query: 451 P-MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
           P ++ S   P   PPP + PP  L +  PQ P A                  Q PF P  
Sbjct: 451 PGLTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGG 489

Query: 510 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 569
             P++P   P    PP       Q P S  A+           P P   +    L  A  
Sbjct: 490 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 549

Query: 570 PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608
           P  PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 550 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 589



 Score =  124 bits (312), Expect = 3e-28
 Identities = 157/559 (28%), Positives = 204/559 (36%), Gaps = 75/559 (13%)

Query: 169 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
           RRSR + + +   R    A P   T    + + S+  +S +  S ++    S    +++ 
Sbjct: 21  RRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN--DSKAETVKKS 78

Query: 229 ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR---KDAAP 285
           A +    +++PL S  R               S  K K  +  RP   +       D+  
Sbjct: 79  AKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRS 138

Query: 286 ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 345
                SS P      +   SPS P S Q   S   +   Q       P LQA     P+P
Sbjct: 139 VNDEGSSDPKDIDQDNRSTSPSIP-SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 197

Query: 346 PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA--VHLLQAPFSP 403
             +P  TP    P     P   A   PP   P +  A   PQAP A     H+ QAP   
Sbjct: 198 SSAPPGTPQLPTPG----PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH 253

Query: 404 PPSPPV-QAPFSPPASPPVSP---SATPPSQAPPSLAAPPL--QVPPSP---PASPPMSP 454
           P  PP    P  P   PP+ P   SA  PS   PS A PPL  Q PP P    A P +  
Sbjct: 254 PQRPPSPHPPPHPSPHPPLQPLTGSAGQPSA--PSHAQPPLHGQGPPGPHSLQAGPLLQH 311

Query: 455 SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPM 513
              P P   PP A+      + P    PA A P     LP+  ++   Q P      LP 
Sbjct: 312 PGPPQPFGLPPQASQ----GQAPLGTSPAAAYPHTSLQLPASQSALQSQQP-PREQPLPP 366

Query: 514 SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP 573
           +PLA P  + PP    P L  P         QA + PP       +SGP    ++    P
Sbjct: 367 APLAMPHIKPPPTTPIPQLPAP---------QAHKHPP------HLSGPS-PFSMNANLP 410

Query: 574 PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------AC 627
           PPP+  P S+LS      H  SA   P +L    S P   + A PP   +        A 
Sbjct: 411 PPPALKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPAS 465

Query: 628 HPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 687
           HP       AP   F   P  P   PP T P              P ++TP  G      
Sbjct: 466 HPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG------ 507

Query: 688 SPGTSGGKAAAGAGAGASS 706
            PGTS     +GA A   S
Sbjct: 508 -PGTSAQPPCSGAAASGGS 525



 Score =  104 bits (260), Expect = 3e-22
 Identities = 135/520 (25%), Positives = 191/520 (36%), Gaps = 115/520 (22%)

Query: 68  ATIPESAPRAGPTRT-----SRP--PASGRGERAPPAK-----NTSPGPVSSPGRASGTT 115
           A+  E A R    +T     SRP  P+ G GE +         ++ P  +    R++  +
Sbjct: 101 ASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPS 160

Query: 116 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 175
            P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A      G
Sbjct: 161 IPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----PPG 203

Query: 176 T-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS---- 230
           T ++  P P PSA   PP   P  S +     + T P P    + +     QRP S    
Sbjct: 204 TPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPP 263

Query: 231 ---------RSLSSSATPLSSPARSGPSARGT-PRAP---------AHPSQPKPKGLQAL 271
                    + L+ SA   S+P+ + P   G  P  P          HP  P+P GL   
Sbjct: 264 PHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL--- 320

Query: 272 RPPQVTPPRKD--AAPALG--------PLSSSPLATPSPSA----PPSPSA-----PPSL 312
            PPQ +  +     +PA          P S S L +  P      PP+P A     PP  
Sbjct: 321 -PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPT 379

Query: 313 QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPALALPPLQAPPS 371
             +P  PA    +    L  P+  + ++ LP PP L PL++     PP+   PPLQ  P 
Sbjct: 380 TPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ 439

Query: 372 P---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPPASPPVSPSATP 427
               P+SP   P  T S   P   A H         P PP  Q PF P   PP++P   P
Sbjct: 440 SQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCP 499

Query: 428 PSQAPP-------------------------SLAAPPLQVP---------PSPPASPPMS 453
            +  PP                         S   P +Q+          P  P  PP S
Sbjct: 500 STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRS 559

Query: 454 PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
           PS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 560 PSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 599



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/444 (28%), Positives = 163/444 (36%), Gaps = 71/444 (15%)

Query: 14  ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
           A+ PA +AP  +TP     PPG+P+ P P  TP+A  V          P A +A      
Sbjct: 182 AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----SPTASQAPN---- 232

Query: 69  TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128
                AP A    T    A     + PP+ +  P P   P     T   G  GQ      
Sbjct: 233 --QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLT---GSAGQPSAPSH 287

Query: 129 AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA-AGTEVGLPRPAPSA 187
           A+  +  G+    P   +L AG      GP      P  A + +A  GT           
Sbjct: 288 AQPPL-HGQGPPGP--HSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTS---------- 334

Query: 188 RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 247
              P    P  S+   +  S  +     R +P        PA  ++     P ++P    
Sbjct: 335 ---PAAAYPHTSLQLPASQSALQSQQPPREQPLP------PAPLAMPHIKPPPTTPIPQL 385

Query: 248 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS 307
           P+ +   + P H S P P  + A  PP          PAL PLSS     P  + PP   
Sbjct: 386 PAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKPLSSLSTHHPPSAHPPPLQ 435

Query: 308 APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP--QAPPALALPP 365
             P  Q LPS PA PP   T S   P   A+H   P   L  +A  PP  Q P     PP
Sbjct: 436 LMPQSQPLPSSPAQPPG-LTQSQNLPPPPASH---PPTGLHQVAPQPPFAQHPFVPGGPP 491

Query: 366 LQAPPSPP--ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ----------APF 413
              PP+ P  ++PP  P  +  P    A A     A  S  P P VQ           P 
Sbjct: 492 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 551

Query: 414 SPPASPPVSPSATPPSQAPPSLAA 437
           SPP  PP SPS  P     PS A+
Sbjct: 552 SPP-PPPRSPSPEPTVVDTPSHAS 574



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 493 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 551
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 159 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 208

Query: 552 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 611
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 209 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 255

Query: 612 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 666
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 256 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 298

Query: 667 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 726
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 299 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 338

Query: 727 VQHLLSRTLLLAAAEGA 743
             H    +L L A++ A
Sbjct: 339 YPH---TSLQLPASQSA 352



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 144/644 (22%), Positives = 201/644 (31%), Gaps = 86/644 (13%)

Query: 25  LTPRPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTS 83
           L P P   P   PPP TP  +  L A  A    P       + G + P S     P   +
Sbjct: 364 LPPAPLAMPHIKPPPTTP--IPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 414

Query: 84  RPPASGRGERAPPAKNTSP---GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 140
             P S      PP+ +  P    P S P  +S    PG    + L          G    
Sbjct: 415 LKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQV 474

Query: 141 APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV 200
           AP+     A       GP P TP    +  +  AG         P    +PP  G   S 
Sbjct: 475 APQPPF--AQHPFVPGGPPPITPPTCPSTSTPPAG---------PGTSAQPPCSGAAASG 523

Query: 201 SSASEHSTTEPSPAARRRPSAGGGLQRPAS-----RSLSSSATPLSSPARSGPSARGTPR 255
            S +  S+  P P  + +  A    + P S     RS S   T + +P+ +  SAR    
Sbjct: 524 GSIAGGSSC-PLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKH 582

Query: 256 APAHPSQPKPKGL--QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQ 313
                +      L    L   ++   R++A        +   A                +
Sbjct: 583 LDRGYNSCARTDLYFMPLAGSKLAKKREEAIEK-AKREAEQKAREEREREKEKEKERERE 641

Query: 314 TLPSPPATPPSQATTS-----LGSPTLQATHSFLPS---PPLSPLATPPPQAPPALALPP 365
                 A   ++A++S     L  P L       PS   PP +  A PP   P   AL  
Sbjct: 642 REREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRT 701

Query: 366 LQAPPSPPASPPLS---PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
           L     P    P +   P   P       LA H+    ++  P+   +            
Sbjct: 702 LSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM-PGLYNVDPTIRERELREREIREREI 760

Query: 423 PSATPPSQAPPSLAAPPLQVPPSPPASPPM------SPSATPPPQAPPPLAA-----PPL 471
                  +  P     P ++ P  PA+ PM      S    PP   P P A+      PL
Sbjct: 761 RERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPL 820

Query: 472 Q---LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 528
           +   LA   PQ  P ++ P   A     A         P A L M  +     Q   + +
Sbjct: 821 ERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHS 880

Query: 529 APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP- 587
              L         P  Q    P  P  D   +GP L        P PP   P+  L  P 
Sbjct: 881 HLHLH-----QQDPLHQGSAGPVHPLVDPLTAGPHLARF-----PYPPGTLPNPLLGQPP 930

Query: 588 ---DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 628
              ++  H    T  P +L G          A PPP   ++A H
Sbjct: 931 HEHEMLRHPVFGTPYPRDLPG----------AIPPP---MSAAH 961


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  134 bits (337), Expect = 3e-31
 Identities = 181/640 (28%), Positives = 230/640 (35%), Gaps = 140/640 (21%)

Query: 56   KPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 115
            KP+ E   G+ G     +    G   T R   SGR ++ P + +    P++   R+SG  
Sbjct: 557  KPVKEEDDGLSGKHSMRTRRSRGSMSTLR---SGR-KKQPASPDGRTSPINEDIRSSGRN 612

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPAMARRSR 172
             P          SA  T +     E  K+SA     + + S P            +    
Sbjct: 613  SP----------SAASTSSNDSKAETVKKSAKKV--KEEASSPLKSNKRQREKVASDTEE 660

Query: 173  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH-----------------STTEPSPAA 215
            A  T     +    +RP  P+EG  +S  S S +                 S + PSP  
Sbjct: 661  ADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQD 720

Query: 216  RRRPSAGGGLQR-----PASRSLSSSATPLSSPARSG----PSARGTPRAPAHPSQPKPK 266
                S     Q+     P +    +  TP  S A  G    P+   TP A A P Q  P 
Sbjct: 721  NESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPT 780

Query: 267  GLQALRPPQV-TPP----RKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL------ 315
              QA   PQ  T P        APAL      P   PSP  PP PS  P LQ L      
Sbjct: 781  ASQAPNQPQAPTAPVPHTHIQQAPAL-----HPQRPPSPHPPPHPSPHPPLQPLTGSAGQ 835

Query: 316  PSPP--ATPPSQATTSLGSPTLQATHSFL-PSPPL------------SPLATPPPQA--- 357
            PS P  A PP       G  +LQA      P PP             +PL T P  A   
Sbjct: 836  PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPH 895

Query: 358  -----------------------PPA-LALPPLQAPPSPPASPPLSPLATPSPQAPNALA 393
                                   PPA LA+P ++ PP+ P  P L     P+PQA     
Sbjct: 896  TSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPI-PQL-----PAPQAHKHPP 949

Query: 394  VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASP 450
                 +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA P
Sbjct: 950  HLSGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQP 1004

Query: 451  P-MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
            P ++ S   P   PPP + PP  L +  PQ P A                  Q PF P  
Sbjct: 1005 PGLTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGG 1043

Query: 510  SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 569
              P++P   P    PP       Q P S  A+           P P   +    L  A  
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 570  PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608
            P  PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 1143



 Score =  124 bits (312), Expect = 3e-28
 Identities = 157/559 (28%), Positives = 204/559 (36%), Gaps = 75/559 (13%)

Query: 169  RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
            RRSR + + +   R    A P   T    + + S+  +S +  S ++    S    +++ 
Sbjct: 575  RRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN--DSKAETVKKS 632

Query: 229  ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR---KDAAP 285
            A +    +++PL S  R               S  K K  +  RP   +       D+  
Sbjct: 633  AKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRS 692

Query: 286  ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 345
                 SS P      +   SPS P S Q   S   +   Q       P LQA     P+P
Sbjct: 693  VNDEGSSDPKDIDQDNRSTSPSIP-SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 751

Query: 346  PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA--VHLLQAPFSP 403
              +P  TP    P     P   A   PP   P +  A   PQAP A     H+ QAP   
Sbjct: 752  SSAPPGTPQLPTPG----PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH 807

Query: 404  PPSPPV-QAPFSPPASPPVSP---SATPPSQAPPSLAAPPL--QVPPSP---PASPPMSP 454
            P  PP    P  P   PP+ P   SA  PS   PS A PPL  Q PP P    A P +  
Sbjct: 808  PQRPPSPHPPPHPSPHPPLQPLTGSAGQPSA--PSHAQPPLHGQGPPGPHSLQAGPLLQH 865

Query: 455  SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPM 513
               P P   PP A+      + P    PA A P     LP+  ++   Q P      LP 
Sbjct: 866  PGPPQPFGLPPQASQ----GQAPLGTSPAAAYPHTSLQLPASQSALQSQQP-PREQPLPP 920

Query: 514  SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP 573
            +PLA P  + PP    P L  P         QA + PP       +SGP    ++    P
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAP---------QAHKHPP------HLSGPS-PFSMNANLP 964

Query: 574  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------AC 627
            PPP+  P S+LS      H  SA   P +L    S P   + A PP   +        A 
Sbjct: 965  PPPALKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPAS 1019

Query: 628  HPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 687
            HP       AP   F   P  P   PP T P              P ++TP  G      
Sbjct: 1020 HPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG------ 1061

Query: 688  SPGTSGGKAAAGAGAGASS 706
             PGTS     +GA A   S
Sbjct: 1062 -PGTSAQPPCSGAAASGGS 1079



 Score =  104 bits (260), Expect = 3e-22
 Identities = 135/520 (25%), Positives = 191/520 (36%), Gaps = 115/520 (22%)

Query: 68   ATIPESAPRAGPTRT-----SRP--PASGRGERAPPAK-----NTSPGPVSSPGRASGTT 115
            A+  E A R    +T     SRP  P+ G GE +         ++ P  +    R++  +
Sbjct: 655  ASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPS 714

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 175
             P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A      G
Sbjct: 715  IPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----PPG 757

Query: 176  T-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS---- 230
            T ++  P P PSA   PP   P  S +     + T P P    + +     QRP S    
Sbjct: 758  TPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPP 817

Query: 231  ---------RSLSSSATPLSSPARSGPSARGT-PRAP---------AHPSQPKPKGLQAL 271
                     + L+ SA   S+P+ + P   G  P  P          HP  P+P GL   
Sbjct: 818  PHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL--- 874

Query: 272  RPPQVTPPRKD--AAPALG--------PLSSSPLATPSPSA----PPSPSA-----PPSL 312
             PPQ +  +     +PA          P S S L +  P      PP+P A     PP  
Sbjct: 875  -PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPT 933

Query: 313  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPALALPPLQAPPS 371
              +P  PA    +    L  P+  + ++ LP PP L PL++     PP+   PPLQ  P 
Sbjct: 934  TPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ 993

Query: 372  P---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPPASPPVSPSATP 427
                P+SP   P  T S   P   A H         P PP  Q PF P   PP++P   P
Sbjct: 994  SQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCP 1053

Query: 428  PSQAPP-------------------------SLAAPPLQVP---------PSPPASPPMS 453
             +  PP                         S   P +Q+          P  P  PP S
Sbjct: 1054 STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRS 1113

Query: 454  PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
            PS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 1114 PSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 1153



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/444 (28%), Positives = 163/444 (36%), Gaps = 71/444 (15%)

Query: 14   ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
            A+ PA +AP  +TP     PPG+P+ P P  TP+A  V          P A +A      
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----SPTASQAPN---- 786

Query: 69   TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128
                 AP A    T    A     + PP+ +  P P   P     T   G  GQ      
Sbjct: 787  --QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLT---GSAGQPSAPSH 841

Query: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA-AGTEVGLPRPAPSA 187
            A+  +  G+    P   +L AG      GP      P  A + +A  GT           
Sbjct: 842  AQPPL-HGQGPPGP--HSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTS---------- 888

Query: 188  RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 247
               P    P  S+   +  S  +     R +P        PA  ++     P ++P    
Sbjct: 889  ---PAAAYPHTSLQLPASQSALQSQQPPREQPLP------PAPLAMPHIKPPPTTPIPQL 939

Query: 248  PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS 307
            P+ +   + P H S P P  + A  PP          PAL PLSS     P  + PP   
Sbjct: 940  PAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKPLSSLSTHHPPSAHPPPLQ 989

Query: 308  APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP--QAPPALALPP 365
              P  Q LPS PA PP   T S   P   A+H   P   L  +A  PP  Q P     PP
Sbjct: 990  LMPQSQPLPSSPAQPPG-LTQSQNLPPPPASH---PPTGLHQVAPQPPFAQHPFVPGGPP 1045

Query: 366  LQAPPSPP--ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ----------APF 413
               PP+ P  ++PP  P  +  P    A A     A  S  P P VQ           P 
Sbjct: 1046 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105

Query: 414  SPPASPPVSPSATPPSQAPPSLAA 437
            SPP  PP SPS  P     PS A+
Sbjct: 1106 SPP-PPPRSPSPEPTVVDTPSHAS 1128



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 493 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 551
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 762

Query: 552 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 611
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 763 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 809

Query: 612 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 666
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 810 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 852

Query: 667 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 726
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 853 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 892

Query: 727 VQHLLSRTLLLAAAEGA 743
             H    +L L A++ A
Sbjct: 893 YPH---TSLQLPASQSA 906



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 144/644 (22%), Positives = 201/644 (31%), Gaps = 86/644 (13%)

Query: 25   LTPRPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTS 83
            L P P   P   PPP TP  +  L A  A    P       + G + P S     P   +
Sbjct: 918  LPPAPLAMPHIKPPPTTP--IPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 968

Query: 84   RPPASGRGERAPPAKNTSP---GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 140
              P S      PP+ +  P    P S P  +S    PG    + L          G    
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQV 1028

Query: 141  APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV 200
            AP+     A       GP P TP    +  +  AG         P    +PP  G   S 
Sbjct: 1029 APQPPF--AQHPFVPGGPPPITPPTCPSTSTPPAG---------PGTSAQPPCSGAAASG 1077

Query: 201  SSASEHSTTEPSPAARRRPSAGGGLQRPAS-----RSLSSSATPLSSPARSGPSARGTPR 255
             S +  S+  P P  + +  A    + P S     RS S   T + +P+ +  SAR    
Sbjct: 1078 GSIAGGSSC-PLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKH 1136

Query: 256  APAHPSQPKPKGL--QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQ 313
                 +      L    L   ++   R++A        +   A                +
Sbjct: 1137 LDRGYNSCARTDLYFMPLAGSKLAKKREEAIEK-AKREAEQKAREEREREKEKEKERERE 1195

Query: 314  TLPSPPATPPSQATTS-----LGSPTLQATHSFLPS---PPLSPLATPPPQAPPALALPP 365
                  A   ++A++S     L  P L       PS   PP +  A PP   P   AL  
Sbjct: 1196 REREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRT 1255

Query: 366  LQAPPSPPASPPLS---PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            L     P    P +   P   P       LA H+    ++  P+   +            
Sbjct: 1256 LSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM-PGLYNVDPTIRERELREREIREREI 1314

Query: 423  PSATPPSQAPPSLAAPPLQVPPSPPASPPM------SPSATPPPQAPPPLAA-----PPL 471
                   +  P     P ++ P  PA+ PM      S    PP   P P A+      PL
Sbjct: 1315 RERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPL 1374

Query: 472  Q---LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 528
            +   LA   PQ  P ++ P   A     A         P A L M  +     Q   + +
Sbjct: 1375 ERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHS 1434

Query: 529  APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP- 587
               L         P  Q    P  P  D   +GP L        P PP   P+  L  P 
Sbjct: 1435 HLHLH-----QQDPLHQGSAGPVHPLVDPLTAGPHLARF-----PYPPGTLPNPLLGQPP 1484

Query: 588  ---DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 628
               ++  H    T  P +L G          A PPP   ++A H
Sbjct: 1485 HEHEMLRHPVFGTPYPRDLPG----------AIPPP---MSAAH 1515


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  134 bits (337), Expect = 3e-31
 Identities = 181/640 (28%), Positives = 230/640 (35%), Gaps = 140/640 (21%)

Query: 56   KPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 115
            KP+ E   G+ G     +    G   T R   SGR ++ P + +    P++   R+SG  
Sbjct: 557  KPVKEEDDGLSGKHSMRTRRSRGSMSTLR---SGR-KKQPASPDGRTSPINEDIRSSGRN 612

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPAMARRSR 172
             P          SA  T +     E  K+SA     + + S P            +    
Sbjct: 613  SP----------SAASTSSNDSKAETVKKSAKKV--KEEASSPLKSNKRQREKVASDTEE 660

Query: 173  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH-----------------STTEPSPAA 215
            A  T     +    +RP  P+EG  +S  S S +                 S + PSP  
Sbjct: 661  ADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQD 720

Query: 216  RRRPSAGGGLQR-----PASRSLSSSATPLSSPARSG----PSARGTPRAPAHPSQPKPK 266
                S     Q+     P +    +  TP  S A  G    P+   TP A A P Q  P 
Sbjct: 721  NESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPT 780

Query: 267  GLQALRPPQV-TPP----RKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL------ 315
              QA   PQ  T P        APAL      P   PSP  PP PS  P LQ L      
Sbjct: 781  ASQAPNQPQAPTAPVPHTHIQQAPAL-----HPQRPPSPHPPPHPSPHPPLQPLTGSAGQ 835

Query: 316  PSPP--ATPPSQATTSLGSPTLQATHSFL-PSPPL------------SPLATPPPQA--- 357
            PS P  A PP       G  +LQA      P PP             +PL T P  A   
Sbjct: 836  PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPH 895

Query: 358  -----------------------PPA-LALPPLQAPPSPPASPPLSPLATPSPQAPNALA 393
                                   PPA LA+P ++ PP+ P  P L     P+PQA     
Sbjct: 896  TSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPI-PQL-----PAPQAHKHPP 949

Query: 394  VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASP 450
                 +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA P
Sbjct: 950  HLSGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQP 1004

Query: 451  P-MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
            P ++ S   P   PPP + PP  L +  PQ P A                  Q PF P  
Sbjct: 1005 PGLTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGG 1043

Query: 510  SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 569
              P++P   P    PP       Q P S  A+           P P   +    L  A  
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 570  PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608
            P  PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 1143



 Score =  124 bits (312), Expect = 3e-28
 Identities = 157/559 (28%), Positives = 204/559 (36%), Gaps = 75/559 (13%)

Query: 169  RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
            RRSR + + +   R    A P   T    + + S+  +S +  S ++    S    +++ 
Sbjct: 575  RRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN--DSKAETVKKS 632

Query: 229  ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR---KDAAP 285
            A +    +++PL S  R               S  K K  +  RP   +       D+  
Sbjct: 633  AKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRS 692

Query: 286  ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 345
                 SS P      +   SPS P S Q   S   +   Q       P LQA     P+P
Sbjct: 693  VNDEGSSDPKDIDQDNRSTSPSIP-SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 751

Query: 346  PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA--VHLLQAPFSP 403
              +P  TP    P     P   A   PP   P +  A   PQAP A     H+ QAP   
Sbjct: 752  SSAPPGTPQLPTPG----PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH 807

Query: 404  PPSPPV-QAPFSPPASPPVSP---SATPPSQAPPSLAAPPL--QVPPSP---PASPPMSP 454
            P  PP    P  P   PP+ P   SA  PS   PS A PPL  Q PP P    A P +  
Sbjct: 808  PQRPPSPHPPPHPSPHPPLQPLTGSAGQPSA--PSHAQPPLHGQGPPGPHSLQAGPLLQH 865

Query: 455  SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPM 513
               P P   PP A+      + P    PA A P     LP+  ++   Q P      LP 
Sbjct: 866  PGPPQPFGLPPQASQ----GQAPLGTSPAAAYPHTSLQLPASQSALQSQQP-PREQPLPP 920

Query: 514  SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP 573
            +PLA P  + PP    P L  P         QA + PP       +SGP    ++    P
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAP---------QAHKHPP------HLSGPS-PFSMNANLP 964

Query: 574  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------AC 627
            PPP+  P S+LS      H  SA   P +L    S P   + A PP   +        A 
Sbjct: 965  PPPALKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPAS 1019

Query: 628  HPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 687
            HP       AP   F   P  P   PP T P              P ++TP  G      
Sbjct: 1020 HPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG------ 1061

Query: 688  SPGTSGGKAAAGAGAGASS 706
             PGTS     +GA A   S
Sbjct: 1062 -PGTSAQPPCSGAAASGGS 1079



 Score =  104 bits (260), Expect = 3e-22
 Identities = 135/520 (25%), Positives = 191/520 (36%), Gaps = 115/520 (22%)

Query: 68   ATIPESAPRAGPTRT-----SRP--PASGRGERAPPAK-----NTSPGPVSSPGRASGTT 115
            A+  E A R    +T     SRP  P+ G GE +         ++ P  +    R++  +
Sbjct: 655  ASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPS 714

Query: 116  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 175
             P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A      G
Sbjct: 715  IPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----PPG 757

Query: 176  T-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS---- 230
            T ++  P P PSA   PP   P  S +     + T P P    + +     QRP S    
Sbjct: 758  TPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPP 817

Query: 231  ---------RSLSSSATPLSSPARSGPSARGT-PRAP---------AHPSQPKPKGLQAL 271
                     + L+ SA   S+P+ + P   G  P  P          HP  P+P GL   
Sbjct: 818  PHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL--- 874

Query: 272  RPPQVTPPRKD--AAPALG--------PLSSSPLATPSPSA----PPSPSA-----PPSL 312
             PPQ +  +     +PA          P S S L +  P      PP+P A     PP  
Sbjct: 875  -PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPT 933

Query: 313  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPALALPPLQAPPS 371
              +P  PA    +    L  P+  + ++ LP PP L PL++     PP+   PPLQ  P 
Sbjct: 934  TPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ 993

Query: 372  P---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPPASPPVSPSATP 427
                P+SP   P  T S   P   A H         P PP  Q PF P   PP++P   P
Sbjct: 994  SQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCP 1053

Query: 428  PSQAPP-------------------------SLAAPPLQVP---------PSPPASPPMS 453
             +  PP                         S   P +Q+          P  P  PP S
Sbjct: 1054 STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRS 1113

Query: 454  PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
            PS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 1114 PSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 1153



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/444 (28%), Positives = 163/444 (36%), Gaps = 71/444 (15%)

Query: 14   ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
            A+ PA +AP  +TP     PPG+P+ P P  TP+A  V          P A +A      
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----SPTASQAPN---- 786

Query: 69   TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128
                 AP A    T    A     + PP+ +  P P   P     T   G  GQ      
Sbjct: 787  --QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLT---GSAGQPSAPSH 841

Query: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA-AGTEVGLPRPAPSA 187
            A+  +  G+    P   +L AG      GP      P  A + +A  GT           
Sbjct: 842  AQPPL-HGQGPPGP--HSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTS---------- 888

Query: 188  RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 247
               P    P  S+   +  S  +     R +P        PA  ++     P ++P    
Sbjct: 889  ---PAAAYPHTSLQLPASQSALQSQQPPREQPLP------PAPLAMPHIKPPPTTPIPQL 939

Query: 248  PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS 307
            P+ +   + P H S P P  + A  PP          PAL PLSS     P  + PP   
Sbjct: 940  PAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKPLSSLSTHHPPSAHPPPLQ 989

Query: 308  APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP--QAPPALALPP 365
              P  Q LPS PA PP   T S   P   A+H   P   L  +A  PP  Q P     PP
Sbjct: 990  LMPQSQPLPSSPAQPPG-LTQSQNLPPPPASH---PPTGLHQVAPQPPFAQHPFVPGGPP 1045

Query: 366  LQAPPSPP--ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ----------APF 413
               PP+ P  ++PP  P  +  P    A A     A  S  P P VQ           P 
Sbjct: 1046 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105

Query: 414  SPPASPPVSPSATPPSQAPPSLAA 437
            SPP  PP SPS  P     PS A+
Sbjct: 1106 SPP-PPPRSPSPEPTVVDTPSHAS 1128



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 493 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 551
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 762

Query: 552 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 611
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 763 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 809

Query: 612 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 666
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 810 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 852

Query: 667 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 726
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 853 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 892

Query: 727 VQHLLSRTLLLAAAEGA 743
             H    +L L A++ A
Sbjct: 893 YPH---TSLQLPASQSA 906



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 144/644 (22%), Positives = 201/644 (31%), Gaps = 86/644 (13%)

Query: 25   LTPRPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTS 83
            L P P   P   PPP TP  +  L A  A    P       + G + P S     P   +
Sbjct: 918  LPPAPLAMPHIKPPPTTP--IPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 968

Query: 84   RPPASGRGERAPPAKNTSP---GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 140
              P S      PP+ +  P    P S P  +S    PG    + L          G    
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQV 1028

Query: 141  APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV 200
            AP+     A       GP P TP    +  +  AG         P    +PP  G   S 
Sbjct: 1029 APQPPF--AQHPFVPGGPPPITPPTCPSTSTPPAG---------PGTSAQPPCSGAAASG 1077

Query: 201  SSASEHSTTEPSPAARRRPSAGGGLQRPAS-----RSLSSSATPLSSPARSGPSARGTPR 255
             S +  S+  P P  + +  A    + P S     RS S   T + +P+ +  SAR    
Sbjct: 1078 GSIAGGSSC-PLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKH 1136

Query: 256  APAHPSQPKPKGL--QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQ 313
                 +      L    L   ++   R++A        +   A                +
Sbjct: 1137 LDRGYNSCARTDLYFMPLAGSKLAKKREEAIEK-AKREAEQKAREEREREKEKEKERERE 1195

Query: 314  TLPSPPATPPSQATTS-----LGSPTLQATHSFLPS---PPLSPLATPPPQAPPALALPP 365
                  A   ++A++S     L  P L       PS   PP +  A PP   P   AL  
Sbjct: 1196 REREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRT 1255

Query: 366  LQAPPSPPASPPLS---PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
            L     P    P +   P   P       LA H+    ++  P+   +            
Sbjct: 1256 LSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM-PGLYNVDPTIRERELREREIREREI 1314

Query: 423  PSATPPSQAPPSLAAPPLQVPPSPPASPPM------SPSATPPPQAPPPLAA-----PPL 471
                   +  P     P ++ P  PA+ PM      S    PP   P P A+      PL
Sbjct: 1315 RERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPL 1374

Query: 472  Q---LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 528
            +   LA   PQ  P ++ P   A     A         P A L M  +     Q   + +
Sbjct: 1375 ERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHS 1434

Query: 529  APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP- 587
               L         P  Q    P  P  D   +GP L        P PP   P+  L  P 
Sbjct: 1435 HLHLH-----QQDPLHQGSAGPVHPLVDPLTAGPHLARF-----PYPPGTLPNPLLGQPP 1484

Query: 588  ---DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 628
               ++  H    T  P +L G          A PPP   ++A H
Sbjct: 1485 HEHEMLRHPVFGTPYPRDLPG----------AIPPP---MSAAH 1515


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  132 bits (332), Expect = 1e-30
 Identities = 147/510 (28%), Positives = 175/510 (34%), Gaps = 107/510 (20%)

Query: 181  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240
            P PA      P +EGP    S         PS  A ++P+A  GL               
Sbjct: 645  PSPAQCVCSPPVSEGPVLPQSL--------PSLGAYQQPTAAPGL--------------- 681

Query: 241  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 300
              P  S P+    P    H   P       L PP    P     PA       PLA P+P
Sbjct: 682  --PVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTP 739

Query: 301  SAPPSPSAP-PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP 359
               P   AP P +   P PP  PP  A  S      Q     +P  PL PLA  PPQ PP
Sbjct: 740  L--PQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPP 797

Query: 360  ALALPPLQA-------PPS---------PPASPP--------LSPLATPSPQAPNALAVH 395
               +PP+         PP+         PP  PP        L  LA P P A  AL + 
Sbjct: 798  IPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQ 857

Query: 396  LLQAPFSPP-----------PSPPVQAPFSPPASP-----------------PVSPSATP 427
             ++ P  P            P+ P   P    A P                 PV P+A P
Sbjct: 858  AVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFP 917

Query: 428  ---PSQAPPS--------LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
               P+  PPS         A PP    P  P  PP  P   P P  PP    PP     P
Sbjct: 918  QMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQ-PVLPPQPTLPPQPVLPPQPTRPP 976

Query: 477  PPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP 536
             P  PP    PP   LP  PA      P  P      +P ATP  Q        +L   P
Sbjct: 977  QPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQ--------ILLGHP 1028

Query: 537  SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS--TLSGPDLAGHSS 594
            +P A     A + P  P P  +V  P L   L P  P    + PSS  T+S    +  + 
Sbjct: 1029 APYAVDV--AAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQ 1086

Query: 595  SATSTPEELRGYDSGPEGGAAASPPPDAEL 624
            +AT  P        GP     ASP P  +L
Sbjct: 1087 TATLLPPANPPLPGGP---GIASPCPTVQL 1113



 Score =  128 bits (322), Expect = 2e-29
 Identities = 158/544 (29%), Positives = 208/544 (38%), Gaps = 76/544 (13%)

Query: 210  EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ 269
            +P P     P A   L  P   +L +SAT L+S +        T  + +  SQ     L 
Sbjct: 583  QPGPPEPEEPEADQHLLPP---TLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVM-LG 638

Query: 270  ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP-PATPPSQATT 328
            +L     +P +   +P +      P + PS  A   P+A P L     P PA PP     
Sbjct: 639  SLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPP----- 693

Query: 329  SLGSPTLQATHSFLP--SPPLSPLAT------PPPQAPPALA----LPPLQAP----PSP 372
            SL         SF P   PP +P+ T      PP Q PP LA    LP + AP    P  
Sbjct: 694  SLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQ 753

Query: 373  PASPPLSPLATPSPQ--APNAL-AVHLLQAPFS-----PPPSPPVQAPFSPPASP----- 419
            P  P L P   P+ Q  AP  L  + + QAP       PP  PP+  P  PP +P     
Sbjct: 754  PVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPI--PVVPPITPLAGID 811

Query: 420  ------PVSPSATPPSQAPPSLAAPPLQVP----PSPPASPPMSPSATPPPQAP-PPLAA 468
                  P  P+AT P   PP   +P + +P    P PPASP +   A   P  P  PLA 
Sbjct: 812  GLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAM 871

Query: 469  PPLQLAKPPPQAPPALATPP----LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 524
            P   +    P   P LA  P      ++ S  A  PGQ P  P+A   M+P   PP  +P
Sbjct: 872  PCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQ-PVYPAAFPQMAPTDVPP--SP 928

Query: 525  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
                  +   PP P   P    P +P  P   T    P+  L   P  PP P   P   L
Sbjct: 929  HHTVQNMRATPPQPALPPQPTLPPQPVLPPQPT--LPPQPVLPPQPTRPPQPVLPPQPML 986

Query: 585  SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS--------RGP 636
                +     +    PE L+ +   PE  A A+  P +++   HPA ++          P
Sbjct: 987  PPQPVLPPQPALPVRPEPLQPH--LPEQAAPAA-TPGSQILLGHPAPYAVDVAAQVPTVP 1043

Query: 637  APPLAFRG--APGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG 694
             PP A      P   LP  P   P     L T+  +   +S       L P  +P   GG
Sbjct: 1044 VPPAAVLSPPLPEVLLPAAPELLPQFPSSLATV--SASVQSVPTQTATLLPPANPPLPGG 1101

Query: 695  KAAA 698
               A
Sbjct: 1102 PGIA 1105



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 162/600 (27%), Positives = 216/600 (36%), Gaps = 118/600 (19%)

Query: 2    DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61
            D++  +      +   AA +P      PP S  P   V P +L  LGA     ++P A  
Sbjct: 627  DSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGP---VLPQSLPSLGAY----QQPTA-- 677

Query: 62   AGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKN---TSPGPVSSPGRASGTTRPG 118
            A G+   ++P  A      +    PA       PP      T PG  + PG+     +P 
Sbjct: 678  APGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQ-----QPP 732

Query: 119  PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEV 178
            PL Q                T  P+  A           P P    P +A  S+      
Sbjct: 733  PLAQP---------------TPLPQVLAPQPVVPLQ---PVPPHLPPYLAPASQVGAPAQ 774

Query: 179  GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR-RPSAGGGLQRPASRSLSSSA 237
              P   P A  +P  + P +            P P      P AG     PA   L ++ 
Sbjct: 775  LKPLQMPQAPLQPLAQVPPQM----------PPIPVVPPITPLAGIDGLPPALPDLPTAT 824

Query: 238  TP------LSSPARSGPSARGT--PRAPAHPSQ----PKPKGLQALRPPQVTPPRKDAAP 285
             P        SPA   PS      P +PA P Q    P P G     P +   P    AP
Sbjct: 825  VPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPN---AP 881

Query: 286  ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLG-SP--TLQATHSFL 342
            A  PL +  +A P  +A    SA   L   P  PA  P  A T +  SP  T+Q   +  
Sbjct: 882  ATIPLLA--VAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATP 939

Query: 343  PSPPLSPLATPPPQA--PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 400
            P P L P  T PPQ   PP   LPP    P  P  PP  P+  P P  P        Q  
Sbjct: 940  PQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPP-QPVLPPQPMLPP-------QPV 991

Query: 401  FSPPPSPPVQA-PFSPPASPPVSPSATPPSQ------APPSL----AAPPLQVPPSPPAS 449
              P P+ PV+  P  P      +P+ATP SQ      AP ++      P + VPP+   S
Sbjct: 992  LPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLS 1051

Query: 450  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT--PPLQALPSPPASFPGQAPFSP 507
            PP+     P        AAP L      PQ P +LAT    +Q++P+  A+         
Sbjct: 1052 PPLPEVLLP--------AAPELL-----PQFPSSLATVSASVQSVPTQTAT--------- 1089

Query: 508  SASLPMSPLATPPPQAPPVLAA--PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLT 565
                 + P A PP    P +A+  P +Q+   P         + P  P    S  G  +T
Sbjct: 1090 -----LLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVT 1144



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 104/406 (25%), Positives = 141/406 (34%), Gaps = 64/406 (15%)

Query: 256  APAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS----SPLATPSPSAPPSPSAPPS 311
            AP  P    P  L +L PP+ +   +D+AP    LSS    S LA+    +   PS PP 
Sbjct: 1323 APEAPESSPPLPLSSL-PPEAS---QDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPG 1378

Query: 312  LQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP-PQAPPAL------ALP 364
                P  P++PP  A    G+    +T   +P P     +    P  P  L      + P
Sbjct: 1379 APPAPLAPSSPPVTALPQDGAAPATST---MPEPASGTASQAGGPGTPQGLTSELETSQP 1435

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP-PPSPPVQAPFSPPASPPVSP 423
              +   +P A  PL     P   AP A +     AP  P PP  P  +P S    P +  
Sbjct: 1436 LAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQ 1495

Query: 424  SAT--PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP-QAPPPLAAPPLQLAKPPPQA 480
             A   P +    SLA   L  PP  P  PP  PSA     + PPP         K   + 
Sbjct: 1496 PAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEK 1555

Query: 481  PPALATPPLQALPSPPASFP---GQAPFS--------PSASLPMSPLATPPPQAPPVLAA 529
               L         S  A  P   G   F+        P + +    LA PP   P    +
Sbjct: 1556 LRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPP--VPKEAVS 1613

Query: 530  PLLQVP----PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
              +Q+P         +PT  A     T    T+ S PR  L                   
Sbjct: 1614 GRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGY--------------DRD 1659

Query: 586  GPDLAGHSSSATSTPEELRGY-----------DSGPEGGAAASPPP 620
            G  +A  S    S P+++  +           D G  G ++A PPP
Sbjct: 1660 GRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPP 1705



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 152/617 (24%), Positives = 205/617 (33%), Gaps = 98/617 (15%)

Query: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES 73
            A  PA  AP    P P  S  P      A  +   ++        +++     G + P  
Sbjct: 1319 AEHPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPG 1378

Query: 74   APRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133
            AP A    +S P  +   + A PA +T P P S     +G    GP   +GL    E + 
Sbjct: 1379 APPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAG----GPGTPQGLTSELETSQ 1434

Query: 134  ARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT 193
               +  EAP         +    G  P TP+P  A    A+     LP PAP   P   T
Sbjct: 1435 PLAETHEAP------LAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGT 1488

Query: 194  EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 253
              P          +  +P+P     P+A G +      SL++S  P  SP          
Sbjct: 1489 PQP----------ALGQPAPLL---PAAVGAV------SLATSQLP--SP---------- 1517

Query: 254  PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQ 313
            P  P  P QP      AL      PP     P +G + S+             S    L+
Sbjct: 1518 PLGPTVPPQPP----SALESDGEGPP-----PRVGFVDST-----------IKSLDEKLR 1557

Query: 314  TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA---LALPPLQAPP 370
            TL      P S A  S G+P       F     L PL    P++      LALPP+    
Sbjct: 1558 TLLYQEHVPTSSA--SAGTPVEVGDRDF----TLEPLRGDQPRSEVCGGDLALPPVPKEA 1611

Query: 371  SPPASPPLSPLATPSPQAPNALAV--HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 428
                     PL   S  AP   AV      +  +   SP     +        S S   P
Sbjct: 1612 VSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVP 1671

Query: 429  S--QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486
            S  Q  P+   P    P           SA PPP     +     Q + P      AL +
Sbjct: 1672 SVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGG---QASHPQTLGARALGS 1728

Query: 487  P---PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 543
            P   P Q   S PA   G+  FS  ++     LA+  P +    A P + +  +P +   
Sbjct: 1729 PRKRPEQQDVSSPAKTVGR--FSVVSTQDEWTLAS--PHSLRYSAPPDVYLDEAPSSPDV 1784

Query: 544  LQAPRRPPTPG--------PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS 595
              A RR  T          P +S SG        P   PP  +  S  +SG         
Sbjct: 1785 KLAVRRAQTASSIEVGVGEPVSSDSGDE-----GPRARPPVQKQASLPVSGSVAGDFVKK 1839

Query: 596  ATS-TPEELRGYDSGPE 611
            AT+      R    GPE
Sbjct: 1840 ATAFLQRPSRAGSLGPE 1856



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 94/347 (27%), Positives = 113/347 (32%), Gaps = 54/347 (15%)

Query: 345 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 404
           P L P       +P     PP+                 P P+ P A   HLL     PP
Sbjct: 548 PALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEA-DQHLL-----PP 601

Query: 405 PSPPVQAPFSPPASPPVSPSATPPSQAPPSL----------AAP-PLQVPPSPPASP-PM 452
             P      +  ++      +T  S +  S           AAP P Q   SPP S  P+
Sbjct: 602 TLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPV 661

Query: 453 SPSATPPPQA-PPPLAAPPLQLAK-PPPQAPPALATPPLQALPSPPASF-----PGQAPF 505
            P + P   A   P AAP L +   P P  PP+L     Q  P P  SF     P   P 
Sbjct: 662 LPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQ----QHFPDPAMSFAPVLPPPSTPM 717

Query: 506 SPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR-- 563
                 P  P   PPP A P     +L   P  P  P    P  PP   P + V  P   
Sbjct: 718 PTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPV--PPHLPPYLAPASQVGAPAQL 775

Query: 564 --LTLALAPGPP---PPPSRSPSSTLSG-PDLAGHSSSATSTPEELRGYDSGPEGGAAAS 617
             L +  AP  P    PP   P   +     LAG      + P+        P       
Sbjct: 776 KPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDL-------PTATVPPV 828

Query: 618 PPPD--------AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656
           PPP           LAA  P A    P   +     PGAPL  P  T
Sbjct: 829 PPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRT 875



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 103/424 (24%), Positives = 154/424 (36%), Gaps = 54/424 (12%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA-GGIGGAT 69
            G A  TPA  A        P  P PPP   P+              PL   A G +  AT
Sbjct: 1452 GLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLAT 1511

Query: 70   IPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 129
                +P  GPT   +PP++         ++   GP    G    T +   L +K   +  
Sbjct: 1512 SQLPSPPLGPTVPPQPPSA--------LESDGEGPPPRVGFVDSTIK--SLDEKLRTLLY 1561

Query: 130  EETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP 189
            +E V    A+     + +  G R  T  P  G        RS   G ++ LP P P    
Sbjct: 1562 QEHVPTSSASAG---TPVEVGDRDFTLEPLRGDQP-----RSEVCGGDLALP-PVPKEAV 1612

Query: 190  RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS 249
                + P+  V         E S  A   P+ G  +++  S S+++ ++P S        
Sbjct: 1613 SGRVQLPQPLV---------EKSELA---PTRGAVMEQGTSSSMTAESSPRSMLGYDRDG 1660

Query: 250  ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAP 309
             +    +   PS P+      +RP +V P  +D   A G  S+ P  +   +     S P
Sbjct: 1661 RQVASDSHVVPSVPQDVP-AFVRPARVEPTDRDGGEA-GESSAEPPPSDMGTVGGQASHP 1718

Query: 310  PSL--QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP---QAPPALALP 364
             +L  + L SP   P  Q  +S          S + +     LA+P      APP + L 
Sbjct: 1719 QTLGARALGSPRKRPEQQDVSSPAKTV--GRFSVVSTQDEWTLASPHSLRYSAPPDVYLD 1776

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS------PPPSPPVQAPFSPPAS 418
              +AP SP        LA    Q  +++ V + +   S      P   PPVQ   S P S
Sbjct: 1777 --EAPSSPDVK-----LAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVS 1829

Query: 419  PPVS 422
              V+
Sbjct: 1830 GSVA 1833



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 72/245 (29%), Positives = 95/245 (38%), Gaps = 39/245 (15%)

Query: 458  PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 517
            P P+AP   ++PPL L+  PP+A    A P    L S       Q  F  S  L      
Sbjct: 1322 PAPEAPE--SSPPLPLSSLPPEASQDSA-PYKDQLSSKE-----QPSFLASQQLLSQAGP 1373

Query: 518  TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 577
            + PP APP   APL   P SPP +   Q    P T       SG   T + A GP  P  
Sbjct: 1374 SNPPGAPP---APL--APSSPPVTALPQDGAAPATSTMPEPASG---TASQAGGPGTPQG 1425

Query: 578  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPA 637
             +     S P    H +     P  +        G A  +P P+A  A+   A+  R P 
Sbjct: 1426 LTSELETSQPLAETHEAPLAVQPLVV--------GLAPCTPAPEA--ASTRDASAPREPL 1475

Query: 638  PPLAFRGAPGAPLPWP----PATGPGSADGLCTIYETE------GPESATPAPGALD--- 684
            PP A   +P +  P P    PA    +A G  ++  ++      GP      P AL+   
Sbjct: 1476 PPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDG 1535

Query: 685  PGPSP 689
             GP P
Sbjct: 1536 EGPPP 1540



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 69/237 (29%), Positives = 89/237 (37%), Gaps = 46/237 (19%)

Query: 476  PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 535
            P P+AP +  +PPL     PP +    AP+    S    P      Q        L Q  
Sbjct: 1322 PAPEAPES--SPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQL-------LSQAG 1372

Query: 536  PS-PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 594
            PS PP +P   AP  P +P P T++  P+   A A    P P+   +S   GP      +
Sbjct: 1373 PSNPPGAPP--APLAPSSP-PVTAL--PQDGAAPATSTMPEPASGTASQAGGPGTPQGLT 1427

Query: 595  SATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 654
            S   T + L      P     A  P    LA C PA      A       AP  PLP PP
Sbjct: 1428 SELETSQPLAETHEAP----LAVQPLVVGLAPCTPAP----EAASTRDASAPREPLP-PP 1478

Query: 655  ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG--KAAAGAGAGASSRSP 709
            A                 PE   P+P +  P P+ G       AA GA + A+S+ P
Sbjct: 1479 A-----------------PE---PSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLP 1515



 Score = 37.4 bits (85), Expect = 0.057
 Identities = 32/120 (26%), Positives = 42/120 (35%), Gaps = 9/120 (7%)

Query: 213 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 272
           P     P  G G   PA       A P +  AR GP  R   R+     Q +P GL+A  
Sbjct: 11  PGTLMEPGRGAG---PAGM-----AEPRAKAARPGPQ-RFLRRSVVESDQEEPPGLEAAE 61

Query: 273 PPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGS 332
            P   PP+      L    +  L        P+  AP +L   P  P  P       +G+
Sbjct: 62  APGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGT 121



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 4/97 (4%)

Query: 450 PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
           P +  +  P PQ P PL    L L K            P    P+   + PG AP +P+ 
Sbjct: 55  PGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPG-APGAPAD 113

Query: 510 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 546
           + P  P+ T  P   P+ AA  ++  P+P   P  +A
Sbjct: 114 AGP-EPVGTQEPGPDPIAAA--VETAPAPDGGPREEA 147



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 49/170 (28%), Positives = 61/170 (35%), Gaps = 29/170 (17%)

Query: 62  AGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 121
           AG  G A     A R GP R  R       +  PP    +  P   P        P PL 
Sbjct: 21  AGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQP--------PQPLQ 72

Query: 122 QKGL------RISAEETVARGKATEAPKRSALSA-----GARRDTSGPTP-GTPSPAMAR 169
           ++ L      R+ AE   ARG+   AP  +AL A     GA  D +GP P GT  P    
Sbjct: 73  RRVLLLCKTRRLIAER--ARGRPA-APAPAALVAQPGAPGAPAD-AGPEPVGTQEPGPDP 128

Query: 170 RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP 219
            + A  T      PAP   PR       +     +  +  EP    R  P
Sbjct: 129 IAAAVET-----APAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEP 173



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 44/166 (26%), Positives = 51/166 (30%), Gaps = 18/166 (10%)

Query: 524 PPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV------SGPRLTLALAPGPPPPPS 577
           P  L  P     P+  A P  +A R  P      SV        P L  A APGP PP  
Sbjct: 11  PGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQP 70

Query: 578 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP--PDAELAACHPAAWSRG 635
                 L          +     E  RG  + P   A  + P  P A   A      ++ 
Sbjct: 71  LQRRVLLL-------CKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQE 123

Query: 636 PAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681
           P P         AP    P  GP          E EG   A P PG
Sbjct: 124 PGPDPIAAAVETAP---APDGGPREEAAATVRKEDEGAAEAKPEPG 166



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 72/301 (23%), Positives = 104/301 (34%), Gaps = 36/301 (11%)

Query: 145  SALSAGARRDTSGPT--PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSS 202
            +A   G RR TS      G     + R+ +   +  G    A S+R  PP + P ++   
Sbjct: 1939 TAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTG--HLADSSRG-PPAKDPAQASVG 1995

Query: 203  ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP-- 260
             +  ST     A +         Q+P S   S S+   S  A  G  ARG      HP  
Sbjct: 1996 LTADSTGLSGKAVQT--------QQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTS 2047

Query: 261  ------SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSL-- 312
                  S  KP+      P  V+         LG   SS  +T S +  P P   P+L  
Sbjct: 2048 ERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHV 2107

Query: 313  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP 372
            Q   +         T  L     + T   + +  L P      Q      L  ++A    
Sbjct: 2108 QAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLN---QLKQTQKLQDMEAQAGW 2164

Query: 373  PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS-PSATPPSQA 431
             A  P    A  +P+A   +       P  PP   P+     P A+P +S P+  P S+ 
Sbjct: 2165 AA--PGEARAMTAPRAGVGM-------PRLPPAPGPLSTTVIPGAAPTLSVPTPDPESEK 2215

Query: 432  P 432
            P
Sbjct: 2216 P 2216



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 39/155 (25%), Positives = 56/155 (36%), Gaps = 30/155 (19%)

Query: 102 PGPVSSPGRASG----------TTRPGPLGQKGLRISAEETVARG----KATEAP----- 142
           PG +  PGR +G            RPGP  Q+ LR S  E+        +A EAP     
Sbjct: 11  PGTLMEPGRGAGPAGMAEPRAKAARPGP--QRFLRRSVVESDQEEPPGLEAAEAPGPQPP 68

Query: 143 ----KRSALSAGARR---DTSGPTPGTPSPA-MARRSRAAGTEVGL-PRPAPSARPRPPT 193
               +R  L    RR   + +   P  P+PA +  +  A G      P P  +  P P  
Sbjct: 69  QPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDP 128

Query: 194 EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
                  + A +    E + A  R+   G    +P
Sbjct: 129 IAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKP 163


>gi|239508790 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 490

 Score =  128 bits (321), Expect = 2e-29
 Identities = 137/458 (29%), Positives = 184/458 (40%), Gaps = 57/458 (12%)

Query: 228 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 287
           P    L S   PL SP     S      +  HP  P    L +   P ++P     +P  
Sbjct: 25  PPHHPLVSLHHPLVSPHFPLVSPHHPLVSLHHPVSPHFP-LVSPHHPLMSPHYSLVSPQY 83

Query: 288 GPLSSS-PLATPSPS--APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPS 344
            P+S   PL +P  S  +P  P   P L  +PSPP+  PS               S +PS
Sbjct: 84  SPVSPHCPLVSPHYSLVSPHRPLVSPLLSGVPSPPSDVPSLL-------------SGVPS 130

Query: 345 PPLSPLATPPPQAPPALALPP--LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 402
            P S +++PP   P  L+  P  L   PSPP+  P  P   PSP +     +  + +P S
Sbjct: 131 LP-SDVSSPPSDVPSLLSDVPSLLSGVPSPPSDVPSPPSDVPSPPSDVPSLLSGVPSPPS 189

Query: 403 PPPSPPVQAPFSPPASPPVSPSATPPSQAP--PSLAAPPLQVPPSPPASPPMSPSATPPP 460
             PSPP   P  P   P +S   +PPS  P    + +PP  VP  P   P +S   +PP 
Sbjct: 190 DVPSPPSDVPSPPSDVPLLSDVPSPPSDVPLLSDVPSPPSDVPSLPSDVPSLSGVPSPPS 249

Query: 461 QAPPPLA---APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP--MSP 515
             P  L+   +PP  ++ PP   P  L+  P  +LPS   S     P SP + +P  +S 
Sbjct: 250 DVPSLLSGVPSPPSDIS-PPSDVPSLLSDVP--SLPSDVPSLLSGVP-SPPSDVPSLLSD 305

Query: 516 LATPPPQAP-PVLAAPLLQVPPSPPA---SPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 571
           + +PP   P P    PLL   PSPP+   SP    P  P      + V  P   + L  G
Sbjct: 306 VPSPPSDVPSPPSDIPLLSGVPSPPSDVPSPPSDVPSPPSDVPLLSGVPSPLSDVPLLSG 365

Query: 572 PPPPPSRSPSSTLS------------GPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 619
            P PPS  PS  +S             P      S  +  P  L G  S P G    S P
Sbjct: 366 VPSPPSDVPSLLMSPHRLLMSHYSLVSPHRLDVPSLLSDVPSLLSGVPSSPSG--VPSLP 423

Query: 620 PDAELAACHPAAWSRGPAPPLAFRGAPGAPLP-WPPAT 656
               + +  P+  S  P+P        G P+  W P T
Sbjct: 424 SGVPILSGVPSLPSGVPSP-------SGVPITLWCPLT 454



 Score =  100 bits (248), Expect = 7e-21
 Identities = 110/366 (30%), Positives = 143/366 (39%), Gaps = 48/366 (13%)

Query: 337 ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP--PLSPLATP-SPQAPNALA 393
           +TH  + SP   PL   PP  P      PL +P  P  SP  PL  L  P SP  P    
Sbjct: 11  STHYSVVSPHC-PLV--PPHHPLVSLHHPLVSPHFPLVSPHHPLVSLHHPVSPHFPLVSP 67

Query: 394 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMS 453
            H L +P     SP   +P SP   P VSP  +  S   P L +P L   PSPP+  P  
Sbjct: 68  HHPLMSPHYSLVSPQY-SPVSPHC-PLVSPHYSLVSPHRP-LVSPLLSGVPSPPSDVPSL 124

Query: 454 PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP--LQALPSPPASFPGQAPFSPSASL 511
            S  P         + P  ++ PP   P  L+  P  L  +PSPP+  P           
Sbjct: 125 LSGVP---------SLPSDVSSPPSDVPSLLSDVPSLLSGVPSPPSDVPS---------- 165

Query: 512 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 571
           P S + +PP   P +L+   +  PPS   SP    P  P      + V  P   + L   
Sbjct: 166 PPSDVPSPPSDVPSLLSG--VPSPPSDVPSPPSDVPSPPSDVPLLSDVPSPPSDVPLLSD 223

Query: 572 PPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDA--------E 623
            P PPS  PS     P L+G  S  +  P  L G  S P      SPP D          
Sbjct: 224 VPSPPSDVPSLPSDVPSLSGVPSPPSDVPSLLSGVPSPPSD---ISPPSDVPSLLSDVPS 280

Query: 624 LAACHPAAWSRGPAPPLAFRGAPG--APLPWPPATGPGSADGLCTIYETEGPESATPAPG 681
           L +  P+  S  P+PP      P   + +P PP+  P     +  +     P S  P+P 
Sbjct: 281 LPSDVPSLLSGVPSPP---SDVPSLLSDVPSPPSDVPSPPSDIPLLSGVPSPPSDVPSPP 337

Query: 682 ALDPGP 687
           +  P P
Sbjct: 338 SDVPSP 343



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 112/373 (30%), Positives = 142/373 (38%), Gaps = 72/373 (19%)

Query: 316 PSPPATPPSQATTSLGSPTLQATHSFLPSP--PLSPLATP-PPQAPPALALPPLQAPPSP 372
           P  P  PP     SL  P L + H  L SP  PL  L  P  P  P      PL +P   
Sbjct: 19  PHCPLVPPHHPLVSLHHP-LVSPHFPLVSPHHPLVSLHHPVSPHFPLVSPHHPLMSPHYS 77

Query: 373 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV---------SP 423
             SP  SP+   SP  P     + L +P  P  SP +    SPP+  P          S 
Sbjct: 78  LVSPQYSPV---SPHCPLVSPHYSLVSPHRPLVSPLLSGVPSPPSDVPSLLSGVPSLPSD 134

Query: 424 SATPPSQAP------PSLAA----PPLQVPPSPPASPPMSPSATPP-----PQAPPPLAA 468
            ++PPS  P      PSL +    PP  VP SPP+  P  PS  P      P  P  + +
Sbjct: 135 VSSPPSDVPSLLSDVPSLLSGVPSPPSDVP-SPPSDVPSPPSDVPSLLSGVPSPPSDVPS 193

Query: 469 PPLQLAKPPPQAP-------PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPP 521
           PP  +  PP   P       P    P L  +PSPP+  P      PS    +S + +PP 
Sbjct: 194 PPSDVPSPPSDVPLLSDVPSPPSDVPLLSDVPSPPSDVPSLPSDVPS----LSGVPSPPS 249

Query: 522 QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRL---TLALAPGPPPPPSR 578
             P +L+       PSPP+  +      PP+  P      P L     +L  G P PPS 
Sbjct: 250 DVPSLLSG-----VPSPPSDIS------PPSDVPSLLSDVPSLPSDVPSLLSGVPSPPSD 298

Query: 579 SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAP 638
            PS      D+    S   S P ++      P      SPP D       P+  S  P+P
Sbjct: 299 VPSLL---SDVPSPPSDVPSPPSDI------PLLSGVPSPPSDV------PSPPSDVPSP 343

Query: 639 PLAFRGAPGAPLP 651
           P       G P P
Sbjct: 344 PSDVPLLSGVPSP 356



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 106/372 (28%), Positives = 138/372 (37%), Gaps = 55/372 (14%)

Query: 180 LPRPAPSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRR---PSAGGGLQRPASRSLS 234
           L  P  S  P PP++ P     V S     ++ PS         PS   G+  P S  + 
Sbjct: 106 LVSPLLSGVPSPPSDVPSLLSGVPSLPSDVSSPPSDVPSLLSDVPSLLSGVPSPPS-DVP 164

Query: 235 SSATPLSSPARSGPSA-RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
           S  + + SP    PS   G P  P+    P         P  V  P  D      PL S 
Sbjct: 165 SPPSDVPSPPSDVPSLLSGVPSPPSDVPSP---------PSDVPSPPSDV-----PLLSD 210

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP------L 347
               PSP     PS  P L  +PSPP+  PS        P+   + S +PSPP      L
Sbjct: 211 ---VPSP-----PSDVPLLSDVPSPPSDVPS-------LPSDVPSLSGVPSPPSDVPSLL 255

Query: 348 SPLATPPPQAPPALALPPLQAP-PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS 406
           S + +PP    P   +P L +  PS P+  P      PSP +     +  + +P S  PS
Sbjct: 256 SGVPSPPSDISPPSDVPSLLSDVPSLPSDVPSLLSGVPSPPSDVPSLLSDVPSPPSDVPS 315

Query: 407 PPVQAPFSPPASPPVSPSATPPSQAP-PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP 465
           PP   P       P S   +PPS  P P    P L   PSP +  P+      PP   P 
Sbjct: 316 PPSDIPLLSGVPSPPSDVPSPPSDVPSPPSDVPLLSGVPSPLSDVPLLSGVPSPPSDVPS 375

Query: 466 LAAPP-------LQLAKPPPQAPPALATPP---LQALPSPPASFPGQAPFSPSAS-LPMS 514
           L   P         L  P     P+L +     L  +PS P+  P      P  S +P  
Sbjct: 376 LLMSPHRLLMSHYSLVSPHRLDVPSLLSDVPSLLSGVPSSPSGVPSLPSGVPILSGVPSL 435

Query: 515 PLATPPPQAPPV 526
           P   P P   P+
Sbjct: 436 PSGVPSPSGVPI 447


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score =  126 bits (317), Expect = 7e-29
 Identities = 226/877 (25%), Positives = 300/877 (34%), Gaps = 150/877 (17%)

Query: 22   PGLLTPRPPGSPRPPPPVT-PAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT 80
            P   +P  P SP+PPP V  P+    +     + + P    +G     +  E+ P   P 
Sbjct: 1127 PPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPE 1186

Query: 81   RTSRPPASGRGERAPPAKNT---SPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 137
             T      G      PA +    SP PV +P   SG        Q G  +        G 
Sbjct: 1187 PTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGW 1246

Query: 138  ATEAPKRSAL--SAGARRDTSGPTP-GTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 194
              EA +RS L  S  A  +  G    GT +    R   +   + G+    P  R      
Sbjct: 1247 QNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLR------ 1300

Query: 195  GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ--------RPASRSLSSSATPLSSPARS 246
                 + SA   +      A  R    GGG          RP    L+  A   +SP   
Sbjct: 1301 -----LESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGL 1355

Query: 247  GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP------ 300
              +AR   RA    S+    G  A +PP   P  +  AP   P   SP A   P      
Sbjct: 1356 ALAAR--ERALKESSE----GGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWG 1409

Query: 301  SAPPSPS-------APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-----LS 348
            ++PP P+       A    Q   S PA+PP+   + L        H   P+ P     L 
Sbjct: 1410 ASPPDPARRELGYRAGLGSQE-KSLPASPPAARRSLL--------HRLPPTAPGVGPLLL 1460

Query: 349  PLATPPPQAPPALALPPLQAPPSPPASPPLSP--LATPSPQAP--NALAVHLLQAPFSPP 404
             L T PP   P ++ P   A P  P   PL    L    P+AP  +         P  PP
Sbjct: 1461 QLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPP 1520

Query: 405  PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP-----------LQVPPSPPA----- 448
            PSP    P SP      SP A+  +  P  +  PP           L V P PP      
Sbjct: 1521 PSPRRSVPPSP-----TSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSN 1575

Query: 449  --SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP--LQALPSPPASFPGQAP 504
                P SP    PP   P   AP   L   PP  PPA+A  P  L +  S   S+  +  
Sbjct: 1576 SFEKPESPLTPGPPHPLPDTPAPATPL---PPVPPPAVAAAPPTLDSTASSLTSYDSEV- 1631

Query: 505  FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRL 564
                A+L     A P    PP          P  PA+P   AP+  P P P T  SG   
Sbjct: 1632 ----ATLTQGASAAPGDPHPP---------GPPAPAAPAPAAPQPGPDPPPGTD-SGIEE 1677

Query: 565  TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA---------TSTPEELRGYDSGPEG--- 612
              + +    P  + S +STLS     G  S+           S PE L  Y +  +G   
Sbjct: 1678 VDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAF 1737

Query: 613  GAAASPPPDAELAACHP---------AAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADG 663
            G +++P P        P         A+    P P    R       P    TG G+ DG
Sbjct: 1738 GGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGT-DG 1796

Query: 664  LCTIYETEGPESATPAPGAL------DPGPSPGTSGGKAAA-----GAGAGASSRSPKQA 712
            L  +    GP +A  A G +       P P P  S           G G          A
Sbjct: 1797 LLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLA 1856

Query: 713  RLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVT--GGARAALSDA 770
            +     L  ++AS++  L S+      +  A G      GG+ GGG +  GGA       
Sbjct: 1857 QPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYV---- 1912

Query: 771  ELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDW 807
                  E  S L   R S  S +S     V+S   +W
Sbjct: 1913 -----PERTSSLQRQRLSDDSQSSLLSKPVSSLFQNW 1944



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 193/742 (26%), Positives = 240/742 (32%), Gaps = 201/742 (27%)

Query: 166  AMARRSRA---AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP----------S 212
            A+A R RA   +    G P+P P   P P  E P  +    S H+  EP           
Sbjct: 1356 ALAARERALKESSEGGGAPQPPPRP-PSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPD 1414

Query: 213  PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT----------PRAPAHPSQ 262
            PA R      G   +  S   S  A   S   R  P+A G           P AP HP  
Sbjct: 1415 PARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAP-HPGV 1473

Query: 263  PKPKGLQALRPPQVTP----------PRKDAAPALGPLSSSPLATPSPS----APPSPSA 308
             KP    A   P+  P          PR       GP S      P PS     PPSP++
Sbjct: 1474 SKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTS 1533

Query: 309  PPS-----LQTLPSPPATPPSQATTSLG------SPTLQATHSFLPSPPLSPLATPPPQA 357
            P +     L  L  PP  P                P L+ ++SF    P SPL   PP  
Sbjct: 1534 PRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSF--EKPESPLTPGPPHP 1591

Query: 358  PPALALPPLQAPPSPP----ASPPLSPLATPSPQAPNALAVHLLQ----APFSP-PPSPP 408
             P    P    PP PP    A+PP       S  + ++    L Q    AP  P PP PP
Sbjct: 1592 LPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPP 1651

Query: 409  VQAPFSP-PASPPVSPSATPPSQA------PPSLAAPPLQVPPSPPASPPMSP----SAT 457
              AP +P PA+P   P   P + +        S +  PL+   S      +S     SA 
Sbjct: 1652 --APAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAG 1709

Query: 458  PPPQAPPPLAAPPLQL---------------AKPPPQAPPALATPPL---QALPSPPASF 499
                A   +A+ P  L               + P P  PP L TP     +AL +     
Sbjct: 1710 GGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLR 1769

Query: 500  PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-----PTLQAPRRPPTPG 554
            PG +        P SP  +        L A  L+    PP +     P    P  PP P 
Sbjct: 1770 PGPSGGLRDPVTPTSPTVSVTGAGTDGLLA--LRACSGPPTAGVAGGPVAVEPEVPPVPL 1827

Query: 555  PDTSVSGPRLTLAL--APGPPPPPSRSPSSTLSGPDLA-----------------GHSSS 595
            P T+ S PR  L     PGPPPPP   P +      LA                 G SS+
Sbjct: 1828 P-TASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSA 1886

Query: 596  ATSTPEELRGYDSGP----EGGAAASPPPDAELAA------------CHPAA-----WSR 634
            A       RG   G      GGA+  P   + L                P +     W +
Sbjct: 1887 AGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPK 1946

Query: 635  GPAPPLAF-RGAPGAPLPWPPATGPGSADGLCTIYETEGPE------------------- 674
             P PPL    G        P AT P ++    +    +G E                   
Sbjct: 1947 PPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPA 2006

Query: 675  ---SATPAP----------GALDPG-------------------------PSPGTSGGKA 696
                 +PAP          G L PG                         P PG SGG  
Sbjct: 2007 SEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLG 2066

Query: 697  AAGAGAGASSRSPKQARLGELP 718
             A +GA   SRS    RL  LP
Sbjct: 2067 GALSGA---SRSLSPTRLLSLP 2085



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 214/855 (25%), Positives = 272/855 (31%), Gaps = 179/855 (20%)

Query: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76
            P   + G LTP P G P  P    P  L     A   G  P   R G     +  +S   
Sbjct: 937  PVPSSSGRLTPSPRGGPFNPGSGGP--LPASSPASFDGPSPPDTRVG-----SREKSLYH 989

Query: 77   AGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 136
            +GP     PPA       PP  +    P   P          P  + G           G
Sbjct: 990  SGPL----PPA----HHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETG-----------G 1030

Query: 137  KATEAPKRSALS-----AGARRDTSGPTPGTPSPA-MARRSRAAGTEVG-------LPRP 183
               + P R AL       G R     PTPG PSP+         G+  G       LP  
Sbjct: 1031 SPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPR 1090

Query: 184  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
            A SA    P    R       + +  E        P  GGGL  P + S +S A+P   P
Sbjct: 1091 AASAAMYVPARSGRGRKGPLVKQTKVE------GEPQKGGGL--PPAPSPTSPASPQPPP 1142

Query: 244  ARSGPSARGT-------PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 296
            A + PS + +        +AP+  S  +     +      T P        G  S SP  
Sbjct: 1143 AVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAP 1202

Query: 297  TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 356
              SP  PPSPS  P+       PA+P   AT      T Q   + + +           +
Sbjct: 1203 AMSP-VPPSPSPVPT-------PASPSGPATLDF---TSQFGAALVGAARREGGWQNEAR 1251

Query: 357  APPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-- 414
                L L    A         L   A P P+  ++ ++   +  FS  P   +++  S  
Sbjct: 1252 RRSTLFL-STDAGDEDGGDGGLGTGAAPGPRLRHSKSID--EGMFSAEPYLRLESAGSGA 1308

Query: 415  --------PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP------------PMSP 454
                      A      S+   S  PP     PL      PASP              S 
Sbjct: 1309 GYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESS 1368

Query: 455  SATPPPQAPPPLAAPPLQLAKPPP--QAPPALATPPLQAL-PSPPASFPGQAPF-----S 506
                 PQ PP   +P  +   P P   +P A   P L+    SPP     +  +     S
Sbjct: 1369 EGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGS 1428

Query: 507  PSASLPMSPLATP-------PPQAPPVLAAPLLQVPPSPPA-SPTLQAPRRPPTP----- 553
               SLP SP A         PP AP V    LLQ+   PPA  P +  P R   P     
Sbjct: 1429 QEKSLPASPPAARRSLLHRLPPTAPGV-GPLLLQLGTEPPAPHPGVSKPWRSAAPEEPER 1487

Query: 554  --------------GPDTSVSGPRLTLALAPG-PPPPPSRS-PSSTLSGPDLAGHSSSAT 597
                           P TS  GP       PG PPP P RS P S  S      +     
Sbjct: 1488 LPLHVRFLENCQPRAPVTSGRGP--PSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLL 1545

Query: 598  STPEELRGYDSGPEGGAAASP-PPDAELAACH---PAAWSRGPAPPLAFRGAPGAPLPWP 653
              P      D          P PP  E +       +  + GP  PL    AP  PLP  
Sbjct: 1546 VLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPV 1605

Query: 654  P----ATGPGSADGLC---TIYETE-------------------GPESATPAPGALDPGP 687
            P    A  P + D      T Y++E                    P  A PAP A  PGP
Sbjct: 1606 PPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGP 1665

Query: 688  SPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGS 747
             P            + +SS  P +                   +S    L++     GGS
Sbjct: 1666 DPPPGTDSGIEEVDSRSSSDHPLET------------------ISSASTLSSLSAEGGGS 1707

Query: 748  GGGPGGAEGGGVTGG 762
             GG GGA G GV  G
Sbjct: 1708 AGGGGGA-GAGVASG 1721



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 148/582 (25%), Positives = 197/582 (33%), Gaps = 86/582 (14%)

Query: 166  AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS---AG 222
            A A+++ +A    G    A   + RP  +G   + SS   H   +PS     RPS    G
Sbjct: 827  AAAQQTISASESPGPGGLASLGKHRP--KGFFATESSFDPHHRAQPS---YERPSFLPPG 881

Query: 223  GGLQRPASRSLSSSATPLSSPARSGPSARGTPR--APAHPSQPKPKGLQALRPPQVTPP- 279
             GL     R  S  A     P  + P+ + +     P     P P       PP  TPP 
Sbjct: 882  PGLML---RQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPV 938

Query: 280  -----RKDAAPALGPL---SSSPLATPSPSAPPSPSAPPS---------LQTLPSPPA-- 320
                 R   +P  GP    S  PL   SP++   PS P +           + P PPA  
Sbjct: 939  PSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHH 998

Query: 321  TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA-------PPSPP 373
             PP         P     H+  P PP       P   PP LAL P  +        PSP 
Sbjct: 999  HPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPT 1058

Query: 374  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433
               P SP    S       +       F  PP     A + P  S         P     
Sbjct: 1059 PGAP-SPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARS---GRGRKGPLVKQT 1114

Query: 434  SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
             +   P +    PPA  P SP++   PQ PP +AAP  + + P P             + 
Sbjct: 1115 KVEGEPQKGGGLPPAPSPTSPAS---PQPPPAVAAPSEKNSIPIPTI----------IIK 1161

Query: 494  SPPASFPGQAPFSPSASLPMSPLATPPPQ-------APPVLAAPLLQVPPSPPASPTLQA 546
            +P  S  G++  S  +S    P   P P        + P  A  +  VPPSP   PT  +
Sbjct: 1162 APSTSSSGRS--SQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPAS 1219

Query: 547  PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS----STLSGPDLAGHSSSATSTP-- 600
            P  P T    +      +  A   G     +R  S    ST +G +  G     T     
Sbjct: 1220 PSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPG 1279

Query: 601  EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGA----------PL 650
              LR   S  EG  +A P    E +A   A +    A   A+ G  G+          PL
Sbjct: 1280 PRLRHSKSIDEGMFSAEPYLRLE-SAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPL 1338

Query: 651  PWP---PATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689
              P    A  P S  GL         + ++   GA  P P P
Sbjct: 1339 VHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRP 1380



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 153/622 (24%), Positives = 212/622 (34%), Gaps = 76/622 (12%)

Query: 1    MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
            ++N + +A   +    P+   PG+  P P  S  PP P +P A    G    V   P   
Sbjct: 1495 LENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSV-PPSPTSPRASEENGLPLLVLPPPAPS 1553

Query: 61   RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSS-PGRASGTTRPGP 119
                 G     E  P         PP         P    +PGP    P   +  T   P
Sbjct: 1554 VDVEDGEFLFVEPLP---------PPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPP 1604

Query: 120  LGQKGLRISAE--ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 177
            +    +  +    ++ A    +   + + L+ GA      P P  P PA A  + AA   
Sbjct: 1605 VPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGP-PAPAAPAPAA--- 1660

Query: 178  VGLPRPAPSARP-----------RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 226
               P+P P   P           R  ++ P +++SSAS    T  S +A    SAGGG  
Sbjct: 1661 ---PQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSAS----TLSSLSAEGGGSAGGGGG 1713

Query: 227  RPAS-----RSLSSSATPLSSPARSGPSARGTPRAP--AHPSQPKPKGLQA---LRPPQV 276
              A        L +    L   A  G S  G P  P    PS+ + + L A   LRP   
Sbjct: 1714 AGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPS 1773

Query: 277  TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP----PATPPSQATTSLGS 332
               R    P    +S +   T    A  + S PP+      P    P  PP    T+   
Sbjct: 1774 GGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSL 1833

Query: 333  PTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL 392
            P         P PP  PL  P  Q P A AL  ++A      S  L      S  A  AL
Sbjct: 1834 PRKLLPWEEGPGPPPPPLPGPLAQ-PQASALATVKASIISELSSKLQQFG-GSSAAGGAL 1891

Query: 393  A-----------VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441
                         H   A + P  +  +Q       S   S  + P S    +   PPL 
Sbjct: 1892 PWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQS-SLLSKPVSSLFQNWPKPPL- 1949

Query: 442  VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSP---PAS 498
              P  P    +SP+A   P A  P A+      +        +  P L+  PSP   PAS
Sbjct: 1950 --PPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPAS 2007

Query: 499  FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS-PPASPTLQAPRRPPTPGPDT 557
                +P    +SLP+ P     P    +  +P      S  P +P    P    + G   
Sbjct: 2008 EHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGG 2067

Query: 558  SVSG------PRLTLALAPGPP 573
            ++SG      P   L+L P  P
Sbjct: 2068 ALSGASRSLSPTRLLSLPPDKP 2089



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 151/600 (25%), Positives = 196/600 (32%), Gaps = 135/600 (22%)

Query: 265  PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPS 324
            P+  + L PP ++   K     L  +       P PS     +                 
Sbjct: 771  PQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQ 830

Query: 325  QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP---- 380
            Q  ++  SP      S     P    AT     P   A P  + P   P  P L      
Sbjct: 831  QTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKS 890

Query: 381  ----------LATPSPQAPNALAVHLLQAPFSPP-PSPPVQAPFSPPAS-PPVSPSA--- 425
                      LA P+ +   +L+V     P S   P PP  +P  PP S PPV  S+   
Sbjct: 891  IGAAEDDRPYLAPPAMKFSRSLSV-----PGSEDIPPPPTTSPPEPPYSTPPVPSSSGRL 945

Query: 426  ---------TPPSQAPPSLAAPPLQVPPSPP------------ASPPMSPSATPPP---- 460
                      P S  P   ++P     PSPP             S P+ P+   PP    
Sbjct: 946  TPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHH 1005

Query: 461  -QAPPPL-----AAPP----LQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 510
              APPP      A PP    ++    P   PP LA  P  +L       P   P +PS S
Sbjct: 1006 HHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPS 1065

Query: 511  LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP--PTPGP---DTSVSG-PRL 564
               S          P L     Q+PP   AS  +  P R      GP    T V G P+ 
Sbjct: 1066 HHGSAGGGGGSSQGPALR--YFQLPPR-AASAAMYVPARSGRGRKGPLVKQTKVEGEPQK 1122

Query: 565  TLALAPGP---------PPPPSRSPSSTLSGP-----------DLAGHSSSATSTPEE-- 602
               L P P         PPP   +PS   S P             +G SS  +ST  E  
Sbjct: 1123 GGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPP 1182

Query: 603  LRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA-TGPGSA 661
             +   +G  GG  +SP P          A +  P PP        +P+P P + +GP + 
Sbjct: 1183 TQPEPTGGGGGGGSSPSP----------APAMSPVPP------SPSPVPTPASPSGPATL 1226

Query: 662  D-----GLCTI--------YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS 708
            D     G   +        ++ E    +T    + D G   G  GG    G GA    R 
Sbjct: 1227 DFTSQFGAALVGAARREGGWQNEARRRSTLFL-STDAGDEDGGDGG---LGTGAAPGPRL 1282

Query: 709  PKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALS 768
                 + E   G   A     L S      A  GA  G  G    A GGG  GG+ A  S
Sbjct: 1283 RHSKSIDE---GMFSAEPYLRLES------AGSGAGYGGYGAGSRAYGGG--GGSSAFTS 1331



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 48/155 (30%), Positives = 62/155 (40%), Gaps = 41/155 (26%)

Query: 643 RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALD---PGPSPG--------- 690
           RG PG  L  PPA    ++D    + +         APGA     PGP+ G         
Sbjct: 421 RGPPGTGLTVPPALLRANSDTSMALPDW----MVFSAPGAASSGAPGPTSGSQGQSQPSA 476

Query: 691 -----TSGGKAAAGAGAGASSRSPKQARLGE----LPLGALQASVVQHLLSRTLLLAAAE 741
                +SG   +A +  GA +RSP + R  E     P G   +S               E
Sbjct: 477 PTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPR-----------E 525

Query: 742 GAAGGSG--GGPGGAEGGGVTGGARAALSDAELGR 774
           G AGG+G  GGPGG+ G   + G R  L  A  GR
Sbjct: 526 GPAGGTGGSGGPGGSLG---SRGRRRKLYSAVPGR 557



 Score = 33.5 bits (75), Expect = 0.82
 Identities = 25/80 (31%), Positives = 33/80 (41%), Gaps = 6/80 (7%)

Query: 179 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG----GGLQRPASRSLS 234
           G P P   ++ +     P   +SS +  S + P  A  R PS G       ++P  R  S
Sbjct: 460 GAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRP-S 518

Query: 235 SSATPLSSPARSGPSARGTP 254
           SS TP   PA  G    G P
Sbjct: 519 SSGTPREGPA-GGTGGSGGP 537


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score =  125 bits (315), Expect = 1e-28
 Identities = 176/702 (25%), Positives = 240/702 (34%), Gaps = 164/702 (23%)

Query: 135 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 194
           R K    P+    S G  R + G    + S   A +SR    +    R   ++ P+   +
Sbjct: 16  RKKEAPGPREELRSRG--RASPGGVSTSSSDGKAEKSRQTAKKA---RVEEASTPKVNKQ 70

Query: 195 GPRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLS---------------S 235
           G  + +S +    T  P          RP +   L     RSL+               S
Sbjct: 71  GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130

Query: 236 SATPLSSPA---RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 292
           ++  + SP        S+ G  + PA P  P P     L PP   PP  D+ P     S 
Sbjct: 131 TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP-----LFPPSPQPP--DSTPRQPEASF 183

Query: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352
            P  + +P+   +P  PP+ +   +PP  PP       G      T   L  PP+ P   
Sbjct: 184 EPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG-----TGGVLSGPPMGPKGG 238

Query: 353 ---------------PPPQAPPALALPPLQAPPSPPASPPLSPLATPS-PQAPNALAVHL 396
                          PPP  P  +++    A  +PP  PP +P+   + P AP       
Sbjct: 239 GAASSVGGPNGGKQHPPPTTP--ISVSSSGASGAPPTKPPTTPVGGGNLPSAP------- 289

Query: 397 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-PSPPASPPMSPS 455
                 PP + P   P  PP  PP        S +PP L A PL    PSP A       
Sbjct: 290 ------PPANFPHVTPNLPP--PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG 341

Query: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ------------ALPSPPASFPGQA 503
             P P+  P LA  P  L    P A  +   PP++            A  S  +S    +
Sbjct: 342 LPPGPEKGPTLAPSPHSL----PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS 397

Query: 504 PFSPSASLPMSPLATPPPQA------PPVLAAPLL-------QVPPSPPASPTLQAPRR- 549
           PF  S +LP  P + PPP +      PP    P L       Q PP PP    L A    
Sbjct: 398 PFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457

Query: 550 -----PPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSRSPS 581
                PP+ G  ++   P  T                              PPPP   P 
Sbjct: 458 HPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPH 517

Query: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL--------------AAC 627
               G     H  + + +   LR Y  GP    A  PPP +++              ++ 
Sbjct: 518 PLEGGSSHHAHPYAMSPSLGSLRPYPPGP----AHLPPPHSQVSYSQAGPNGPPVSSSSN 573

Query: 628 HPAAWSRGPAP---PLAFRGAPGAPLPWPPA-TGPGSADGLCTIYETEGPESATPAPGAL 683
             ++ S+G  P   P   +G  GAP P+PP  T   S+  L T+  T    S      A 
Sbjct: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA-SSPAGYKTAS 632

Query: 684 DPGPSPGTSGGKAAAGAGA-------GASSRSPKQARLGELP 718
            PGP P    GK A   GA       G    SP   R G  P
Sbjct: 633 PPGPPP---YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671



 Score =  116 bits (291), Expect = 7e-26
 Identities = 166/655 (25%), Positives = 225/655 (34%), Gaps = 109/655 (16%)

Query: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP--PA 87
           P  P  PPP+ P + +      +  R+P A            E  P   PT    P  P 
Sbjct: 155 PARPYHPPPLFPPSPQ---PPDSTPRQPEASF----------EPHPSVTPTGYHAPMEPP 201

Query: 88  SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 147
           + R  +APP     P P   PG   G     P+G KG   ++      G     P  + +
Sbjct: 202 TSRMFQAPPGA-PPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPI 260

Query: 148 SAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206
           S  +   +  P    P+ P       +A      P   P+  P PP   P  + S++   
Sbjct: 261 SVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPP-PPALRPLNNASASPPG 319

Query: 207 STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA--PAHPSQPK 264
              +P P              P+  ++      L      GP+   +P +  PA  S P 
Sbjct: 320 LGAQPLPG-----------HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPA 368

Query: 265 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS------APPSLQTLPSP 318
           P     +R P  +     AA +    SSS  A+P P++   PS       P SL     P
Sbjct: 369 PP----MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424

Query: 319 PA----TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA------ 368
           P     + PSQA  S G P        L +    P   PP     + A PP+        
Sbjct: 425 PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484

Query: 369 ------------------------PPSPPASP-PL----SPLATPSPQAPN--ALAVHLL 397
                                   PP P A P PL    S  A P   +P+  +L  +  
Sbjct: 485 QQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP 544

Query: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP--------PSLAAPPLQVP-PSPPA 448
                PPP   V    + P  PPVS S+   S           PS +  P   P P PP 
Sbjct: 545 GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604

Query: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP-----------ALATPPLQALPSPPA 497
               + SAT         ++P       PP  PP             ATPP     SPP+
Sbjct: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664

Query: 498 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557
              G  P     S P  P  T  P +P V   PL   P  P   P+L  P   P  GP  
Sbjct: 665 FRTGTPPGYRGTSPPAGP-GTFKPGSPTVGPGPL--PPAGPSGLPSLPPPPAAPASGPPL 721

Query: 558 SVSGPRLTLA---LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608
           S +  +   A     P  P PP+RSPS      D+  H+S +    + L RG++S
Sbjct: 722 SATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776



 Score =  112 bits (281), Expect = 1e-24
 Identities = 148/525 (28%), Positives = 189/525 (36%), Gaps = 78/525 (14%)

Query: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG------GATIPESAPRAGPTRT 82
           P G  + PPP TP ++   GA+GA   KP     GG         A  P   P   P   
Sbjct: 247 PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPA 306

Query: 83  SRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA 138
            RP     AS  G  A P     P P  + G+  G   PGP  +KG       T+A    
Sbjct: 307 LRPLNNASASPPGLGAQPLPGHLPSP-HAMGQGMGGLPPGP--EKG------PTLAPSPH 357

Query: 139 TEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 198
           +  P  S+  A   R     +  + S A A  S ++ +    P PA  A P  P   P  
Sbjct: 358 SLPPASSSAPAPPMRFPYSSS--SSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPP 415

Query: 199 SVSSASEHST--TEPSPAARRRPSAGGGLQRPASRSLSSS-ATPLSSPARSGPSARGTPR 255
           +  S S      T+PS  ++   S G     P  R L++S A P   P  +G  +   P 
Sbjct: 416 TSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP 475

Query: 256 APAHPSQPKPKGLQALRPPQVT-----------PPRKDAAPALGPLSSSPLATP---SPS 301
              H    + +  Q  +  Q             PP   A P      SS  A P   SPS
Sbjct: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPS 535

Query: 302 APPSPSAPPSLQTLPSP----------PATPPSQATTSLGSPTLQATHSFL-PSPPLSPL 350
                  PP    LP P          P  PP  ++++  S T Q ++    PSP   P 
Sbjct: 536 LGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQ 595

Query: 351 ATPPPQAP----------------PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAV 394
             P P  P                   + P      SPP  PP    A PSP A      
Sbjct: 596 GAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA-PSPGAYKTAT- 653

Query: 395 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 454
                P   P SPP     +PP     SP A P +  P S   P +   P PPA P   P
Sbjct: 654 ----PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS---PTVGPGPLPPAGPSGLP 706

Query: 455 SATPPPQAP---PPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496
           S  PPP AP   PPL+A  ++         P    PP ++ PSPP
Sbjct: 707 SLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS-PSPP 750


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score =  125 bits (315), Expect = 1e-28
 Identities = 176/702 (25%), Positives = 240/702 (34%), Gaps = 164/702 (23%)

Query: 135 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 194
           R K    P+    S G  R + G    + S   A +SR    +    R   ++ P+   +
Sbjct: 16  RKKEAPGPREELRSRG--RASPGGVSTSSSDGKAEKSRQTAKKA---RVEEASTPKVNKQ 70

Query: 195 GPRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLS---------------S 235
           G  + +S +    T  P          RP +   L     RSL+               S
Sbjct: 71  GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130

Query: 236 SATPLSSPA---RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 292
           ++  + SP        S+ G  + PA P  P P     L PP   PP  D+ P     S 
Sbjct: 131 TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP-----LFPPSPQPP--DSTPRQPEASF 183

Query: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352
            P  + +P+   +P  PP+ +   +PP  PP       G      T   L  PP+ P   
Sbjct: 184 EPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG-----TGGVLSGPPMGPKGG 238

Query: 353 ---------------PPPQAPPALALPPLQAPPSPPASPPLSPLATPS-PQAPNALAVHL 396
                          PPP  P  +++    A  +PP  PP +P+   + P AP       
Sbjct: 239 GAASSVGGPNGGKQHPPPTTP--ISVSSSGASGAPPTKPPTTPVGGGNLPSAP------- 289

Query: 397 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-PSPPASPPMSPS 455
                 PP + P   P  PP  PP        S +PP L A PL    PSP A       
Sbjct: 290 ------PPANFPHVTPNLPP--PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG 341

Query: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ------------ALPSPPASFPGQA 503
             P P+  P LA  P  L    P A  +   PP++            A  S  +S    +
Sbjct: 342 LPPGPEKGPTLAPSPHSL----PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS 397

Query: 504 PFSPSASLPMSPLATPPPQA------PPVLAAPLL-------QVPPSPPASPTLQAPRR- 549
           PF  S +LP  P + PPP +      PP    P L       Q PP PP    L A    
Sbjct: 398 PFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457

Query: 550 -----PPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSRSPS 581
                PP+ G  ++   P  T                              PPPP   P 
Sbjct: 458 HPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPH 517

Query: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL--------------AAC 627
               G     H  + + +   LR Y  GP    A  PPP +++              ++ 
Sbjct: 518 PLEGGSSHHAHPYAMSPSLGSLRPYPPGP----AHLPPPHSQVSYSQAGPNGPPVSSSSN 573

Query: 628 HPAAWSRGPAP---PLAFRGAPGAPLPWPPA-TGPGSADGLCTIYETEGPESATPAPGAL 683
             ++ S+G  P   P   +G  GAP P+PP  T   S+  L T+  T    S      A 
Sbjct: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA-SSPAGYKTAS 632

Query: 684 DPGPSPGTSGGKAAAGAGA-------GASSRSPKQARLGELP 718
            PGP P    GK A   GA       G    SP   R G  P
Sbjct: 633 PPGPPP---YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671



 Score =  116 bits (291), Expect = 7e-26
 Identities = 166/655 (25%), Positives = 225/655 (34%), Gaps = 109/655 (16%)

Query: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP--PA 87
           P  P  PPP+ P + +      +  R+P A            E  P   PT    P  P 
Sbjct: 155 PARPYHPPPLFPPSPQ---PPDSTPRQPEASF----------EPHPSVTPTGYHAPMEPP 201

Query: 88  SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 147
           + R  +APP     P P   PG   G     P+G KG   ++      G     P  + +
Sbjct: 202 TSRMFQAPPGA-PPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPI 260

Query: 148 SAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206
           S  +   +  P    P+ P       +A      P   P+  P PP   P  + S++   
Sbjct: 261 SVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPP-PPALRPLNNASASPPG 319

Query: 207 STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA--PAHPSQPK 264
              +P P              P+  ++      L      GP+   +P +  PA  S P 
Sbjct: 320 LGAQPLPG-----------HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPA 368

Query: 265 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS------APPSLQTLPSP 318
           P     +R P  +     AA +    SSS  A+P P++   PS       P SL     P
Sbjct: 369 PP----MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424

Query: 319 PA----TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA------ 368
           P     + PSQA  S G P        L +    P   PP     + A PP+        
Sbjct: 425 PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484

Query: 369 ------------------------PPSPPASP-PL----SPLATPSPQAPN--ALAVHLL 397
                                   PP P A P PL    S  A P   +P+  +L  +  
Sbjct: 485 QQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP 544

Query: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP--------PSLAAPPLQVP-PSPPA 448
                PPP   V    + P  PPVS S+   S           PS +  P   P P PP 
Sbjct: 545 GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604

Query: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP-----------ALATPPLQALPSPPA 497
               + SAT         ++P       PP  PP             ATPP     SPP+
Sbjct: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664

Query: 498 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557
              G  P     S P  P  T  P +P V   PL   P  P   P+L  P   P  GP  
Sbjct: 665 FRTGTPPGYRGTSPPAGP-GTFKPGSPTVGPGPL--PPAGPSGLPSLPPPPAAPASGPPL 721

Query: 558 SVSGPRLTLA---LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608
           S +  +   A     P  P PP+RSPS      D+  H+S +    + L RG++S
Sbjct: 722 SATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776



 Score =  112 bits (281), Expect = 1e-24
 Identities = 148/525 (28%), Positives = 189/525 (36%), Gaps = 78/525 (14%)

Query: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG------GATIPESAPRAGPTRT 82
           P G  + PPP TP ++   GA+GA   KP     GG         A  P   P   P   
Sbjct: 247 PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPA 306

Query: 83  SRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA 138
            RP     AS  G  A P     P P  + G+  G   PGP  +KG       T+A    
Sbjct: 307 LRPLNNASASPPGLGAQPLPGHLPSP-HAMGQGMGGLPPGP--EKG------PTLAPSPH 357

Query: 139 TEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 198
           +  P  S+  A   R     +  + S A A  S ++ +    P PA  A P  P   P  
Sbjct: 358 SLPPASSSAPAPPMRFPYSSS--SSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPP 415

Query: 199 SVSSASEHST--TEPSPAARRRPSAGGGLQRPASRSLSSS-ATPLSSPARSGPSARGTPR 255
           +  S S      T+PS  ++   S G     P  R L++S A P   P  +G  +   P 
Sbjct: 416 TSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP 475

Query: 256 APAHPSQPKPKGLQALRPPQVT-----------PPRKDAAPALGPLSSSPLATP---SPS 301
              H    + +  Q  +  Q             PP   A P      SS  A P   SPS
Sbjct: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPS 535

Query: 302 APPSPSAPPSLQTLPSP----------PATPPSQATTSLGSPTLQATHSFL-PSPPLSPL 350
                  PP    LP P          P  PP  ++++  S T Q ++    PSP   P 
Sbjct: 536 LGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQ 595

Query: 351 ATPPPQAP----------------PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAV 394
             P P  P                   + P      SPP  PP    A PSP A      
Sbjct: 596 GAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA-PSPGAYKTAT- 653

Query: 395 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 454
                P   P SPP     +PP     SP A P +  P S   P +   P PPA P   P
Sbjct: 654 ----PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS---PTVGPGPLPPAGPSGLP 706

Query: 455 SATPPPQAP---PPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496
           S  PPP AP   PPL+A  ++         P    PP ++ PSPP
Sbjct: 707 SLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS-PSPP 750


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score =  124 bits (312), Expect = 3e-28
 Identities = 155/606 (25%), Positives = 222/606 (36%), Gaps = 97/606 (16%)

Query: 31  GSPRPPPPVTPAALRV-LGAAGAVGRKPLA---ERAGGIGGATIPESAPRAG-------- 78
           G+  P     PA +   L       R+ +A    RA G+   ++P +A  +         
Sbjct: 28  GAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQEL 87

Query: 79  -----PTRTSRPPASGRGERAPPAKNTSPGPVSS----PGRASGT-TRPGPLGQKGLRIS 128
                P ++ RPP  GR  +   +K+ +     S    PGR+  T +      +  L+  
Sbjct: 88  DSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEE 147

Query: 129 AEETVARGKATEAPKRSALSAGARR----DTSGPTPGTPSPAMARRSRAAGTEVGLPR-- 182
            + ++  G  +E    SA+S+   +    D    +  +      ++ +    E G P   
Sbjct: 148 HKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEET-TKKQKVVQKEQGKPEGI 206

Query: 183 ---------PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
                    P P  + + P   P +   +    S+ +P     + P  G  +Q P     
Sbjct: 207 IKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQ 266

Query: 234 SSSAT-PLSSPA-----RSGPSARGTPRAPAHPSQPKPKGLQAL--RPPQVTPPRKDAAP 285
           +  A  PL   A     +     RG    P+ PS  KP   Q    +PP   P  + + P
Sbjct: 267 TDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326

Query: 286 ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT--PPSQATTSLGSPTLQATHSFLP 343
             GP  + P A PS    P    P +++    PP T  PP+Q       P  Q T S  P
Sbjct: 327 --GP--AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKP 381

Query: 344 SPPLSPLATPPPQA---PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 400
           S        P P+A   PP +   P Q P   PA PP   + TP P A         +AP
Sbjct: 382 SSE-----QPGPKALAQPPGVGKTPAQQPG--PAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 401 FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 460
              P   PVQ P          P   P  QA P   +     P  PP+  P    A PPP
Sbjct: 435 --GPTKTPVQQP---------GPGKIPAQQAGPGKTSAQQTGPTKPPSQLP--GPAKPPP 481

Query: 461 QAPPPLAAPPLQ--LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLAT 518
           Q P P   PP Q   AKPP Q P +   PP Q  P+ P+              P  P +T
Sbjct: 482 QQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS--------------PQQPGST 527

Query: 519 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 578
            PP   P  A P  Q P   PA P+ Q   +P +    T    P     ++P    PPS+
Sbjct: 528 KPPSQQPGSAKPSAQQPS--PAKPSAQQSTKPVS---QTGSGKPLQPPTVSPSAKQPPSQ 582

Query: 579 SPSSTL 584
               T+
Sbjct: 583 GLPKTI 588



 Score =  113 bits (282), Expect = 8e-25
 Identities = 176/718 (24%), Positives = 256/718 (35%), Gaps = 126/718 (17%)

Query: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRP--PPPVTPAALRVLGAAGAVGRKPLAERA 62
           RD  +     ++ +++ P  +  +PPG+ +P   P  TP              +P  ++A
Sbjct: 227 RDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQA 286

Query: 63  GGIGGATI------PESAPRAGPTRTSRPPA-------SGRGERAPPAKNTS-------- 101
             + G ++      P   P   PT   +PPA       S  G   PPA+ +         
Sbjct: 287 DIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQ 345

Query: 102 PGPVSSPGRASGTTRPG--PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 159
           PG V  P +  GTT+P   PLG    +  A++T +   ++E P   AL   A+    G T
Sbjct: 346 PGTVKPPVQPPGTTKPPAQPLGPA--KPPAQQTGSEKPSSEQPGPKAL---AQPPGVGKT 400

Query: 160 PGT-PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 218
           P   P PA     +    +VG P+P      +P  + P K+    ++    +P P     
Sbjct: 401 PAQQPGPA-----KPPTQQVGTPKPLAQ---QPGLQSPAKA-PGPTKTPVQQPGPGKIPA 451

Query: 219 PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 278
             AG G         +   + L  PA+  P   G  + P  P QP      + +P    P
Sbjct: 452 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQQPGSTKP 509

Query: 279 PRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338
           P +   PA  P    P +T  PS  P  SA PS Q  PSP A P +Q +T   S T   +
Sbjct: 510 PPQQPGPAK-PSPQQPGSTKPPSQQPG-SAKPSAQQ-PSP-AKPSAQQSTKPVSQT--GS 563

Query: 339 HSFLPSPPLSPLATPPP-QAPPALALPPLQAPPSPPASPPLSPLAT-------------- 383
              L  P +SP A  PP Q  P    P           P  +   T              
Sbjct: 564 GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGF 623

Query: 384 -PSPQAP--------NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 434
            P+P           N      L    +P PS P     + P +   + S + P      
Sbjct: 624 NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQ----- 678

Query: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA------APPLQLAKPPPQ-------AP 481
               P Q  P   A+P    S  P P+ PPPL         P   AK PP+       AP
Sbjct: 679 ----PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAP 734

Query: 482 PALATPPLQALPSPPASFPGQAP--FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 539
           P   + P +   +P A    + P    P+  L  S  AT  P  P        +   +PP
Sbjct: 735 PKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPP 794

Query: 540 ASPTLQAPRR--PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
                  P +  PPT        G +++   +   P P S S   +  GP      S   
Sbjct: 795 LKTDSAKPSQSFPPT--------GEKVSPFDSKAIPRPASDSKIISHPGP---SSESKGQ 843

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA 655
              + ++  +   +     SP PDA+            P P    +G+P  P P P A
Sbjct: 844 KQVDPVQKKEEPKKAQTKMSPKPDAK------------PMP----KGSPTPPGPRPTA 885



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/746 (23%), Positives = 268/746 (35%), Gaps = 154/746 (20%)

Query: 17   PAARAPGLLTP--RPPGSPRPPP-PVTPAALRVLGAAGAVGRKPLAERAG--------GI 65
            P A+ PG + P  +PPG+ +PP  P+ PA      A      KP +E+ G        G+
Sbjct: 341  PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP---AQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 66   GGATIPESAPRAGPTR---TSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG--PL 120
            G     +  P   PT+   T +P A   G ++P     +PGP  +P +  G   PG  P 
Sbjct: 398  GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAK---APGPTKTPVQQPG---PGKIPA 451

Query: 121  GQKGL-RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG 179
             Q G  + SA++T      T+ P  S L   A+     P P  P P     ++    + G
Sbjct: 452  QQAGPGKTSAQQT----GPTKPP--SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505

Query: 180  LPRPAPS----ARP--------RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 227
              +P P     A+P        +PP++ P  +  SA + S  +PS     +P +  G  +
Sbjct: 506  STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGK 565

Query: 228  PASRSLSSSATPLSSPARSGPSARGTPRA---------------------PAHPSQPKPK 266
            P          P  SP+   P ++G P+                           Q    
Sbjct: 566  PLQ-------PPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVC 618

Query: 267  GLQALRP-PQVTPPRK--------------DAAPALGP----LSSSPLATPSPSAPPSPS 307
             L    P P +T  ++              D AP        L ++P+ T S     S S
Sbjct: 619  SLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTS---AVSKS 675

Query: 308  APPSLQTLPSPPATPP---SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364
            +P   QT P   A P    S+A      P L    +   SP  S  A  PP+A  +L+ P
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP--SAKAKQPPEA-DSLSKP 732

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNAL-----AVHLLQAPFSPP-PSPPVQAPFSPPAS 418
                 PS P+    +P+A   P+ P  +      V    A   P  PS  VQ+      +
Sbjct: 733  APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTT 792

Query: 419  PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP 478
            PP+   +  PSQ+           PP+     P    A P P +   + + P     P  
Sbjct: 793  PPLKTDSAKPSQS----------FPPTGEKVSPFDSKAIPRPASDSKIISHP----GPSS 838

Query: 479  QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            ++       P+Q    P  +   Q   SP       P  +P P              P P
Sbjct: 839  ESKGQKQVDPVQKKEEPKKA---QTKMSPKPDAKPMPKGSPTPPG------------PRP 883

Query: 539  PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR--SPSSTLSGPDLAGHSSSA 596
             A  T+  P++ P P   +     R +L L      P S+  +P  T++G  L G  +S 
Sbjct: 884  TAGQTVPTPQQSPKPQEQSR----RFSLNLGSITDAPKSQPTTPQETVTG-KLFGFGASI 938

Query: 597  TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656
             S    L           A  P P ++     P   +  P+ P   +G P +    PPA 
Sbjct: 939  FSQASNLI--------STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA- 989

Query: 657  GPGSADGLCTIYETEGPESATPAPGA 682
                A  +    ET+ P +    P A
Sbjct: 990  ---PAKSIPVKKETKAPAAEKLEPKA 1012



 Score =  108 bits (269), Expect = 3e-23
 Identities = 188/766 (24%), Positives = 264/766 (34%), Gaps = 132/766 (17%)

Query: 28  RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRT-SRPP 86
           +PP   +PP P+              GR PL +          P+S     P +  S+PP
Sbjct: 208 KPPLQQQPPKPIPKQQ--------GPGRDPLQQDG-------TPKSISSQQPEKIKSQPP 252

Query: 87  ASGRGERAPPAKNTSPGPVSSPGRASGTTRPG-PLGQKGLRISAEET-VARGKATEAPKR 144
            +G+             P+  P +   T     PL +   R   ++  + RG++     +
Sbjct: 253 GTGK-------------PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV----K 295

Query: 145 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA-----PSARPRPPTEGPRKS 199
            +L + ++     PTPG P       ++  G E   P PA     PS   +P  + P   
Sbjct: 296 PSLPSPSKPPIQQPTPGKPP------AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV 349

Query: 200 VSSASEHSTTEP--SPAARRRPSAGG-GLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256
                   TT+P   P    +P A   G ++P+S      A  L+ P    P    TP  
Sbjct: 350 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKA--LAQP----PGVGKTPAQ 403

Query: 257 PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316
              P++P  + +   +P    P  +  A A GP + +P+  P P   P+  A P   +  
Sbjct: 404 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP-TKTPVQQPGPGKIPAQQAGPGKTSAQ 462

Query: 317 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP 376
               T P         P  Q      P P     A PP Q P +   PP Q  P+ P+  
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS-- 520

Query: 377 PLSPLATPSPQAPNALAVHLLQAPFSPPPS------PPVQAPFSPPASPP-VSPSA-TPP 428
           P  P +T  P      A    Q P    PS      P  Q     P  PP VSPSA  PP
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP 580

Query: 429 SQAPPSLAAP-------PLQVPPSPPASPPMSPSAT--------PPPQAP---------- 463
           SQ  P    P        L VP     +       T        P P             
Sbjct: 581 SQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNC 640

Query: 464 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA-SLPMSPL--ATPP 520
               A    LA  P    P L T P+    +   S P     SP   + P   L  A  P
Sbjct: 641 QMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEP 700

Query: 521 PQAPPVLAAPLLQVPPS-----PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575
            + PP++  P L   PS     PP + +L  P  P  P    SV   +    +A   P  
Sbjct: 701 KKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEP----SVPSEQDKAPVADDKPKQ 756

Query: 576 PSR--------SPSSTLSGPDLAG---HSSSATSTPEELRGYDSGPEGGAAASPPPDAEL 624
           P          S SS  + PD+      S +   T   L+   + P    + S PP  E 
Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEK 812

Query: 625 AACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESA----TPAP 680
            +   +     PA        PG   P   + G    D    + + E P+ A    +P P
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPG---PSSESKGQKQVD---PVQKKEEPKKAQTKMSPKP 866

Query: 681 GALD-PGPSPGTSGGKAAAGAGAGASSRSPK---QARLGELPLGAL 722
            A   P  SP   G +  AG       +SPK   Q+R   L LG++
Sbjct: 867 DAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912



 Score =  105 bits (262), Expect = 2e-22
 Identities = 108/408 (26%), Positives = 146/408 (35%), Gaps = 49/408 (12%)

Query: 199 SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258
           S S AS+  TT+     ++      G+ +P  +           P +  P  +G  R P 
Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ---------QPPKPIPKQQGPGRDPL 230

Query: 259 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP 318
                 PK + + +P ++    K   P  G     P  TP       P     LQ   S 
Sbjct: 231 Q-QDGTPKSISSQQPEKI----KSQPPGTGKPIQGPTQTPQTDHAKLP-----LQRDASR 280

Query: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378
           P T   QA    G    ++    LPSP   P+  P P  PPA      ++ P P A PP 
Sbjct: 281 PQT--KQADIVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGP-AKPPA 333

Query: 379 SP--LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436
            P  L  P  Q P  +   +     + PP+ P+  P  PPA    S   +     P +LA
Sbjct: 334 QPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL-GPAKPPAQQTGSEKPSSEQPGPKALA 392

Query: 437 APPLQVPPSP-----PASPPMSPSATPPPQAPPPLAAPPLQLAKP---PPQAPPALATPP 488
            PP  V  +P     PA PP     TP P A  P    P +   P   P Q P     P 
Sbjct: 393 QPP-GVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPA 451

Query: 489 LQALPS-----------PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS 537
            QA P            PP+  PG A   P    P  P    P  A P    P    PP 
Sbjct: 452 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPP 511

Query: 538 PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
               P   +P++P +  P +   G     A  P P  P ++  +  +S
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 141/590 (23%), Positives = 192/590 (32%), Gaps = 82/590 (13%)

Query: 167 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 226
           +A  + A G   G   P+ +A P     G    +S  SE    + +    R      G  
Sbjct: 16  LAAAAAAGGGASGAGSPSHTAIPA----GMEADLSQLSEEERRQIAAVMSRAQGLPKGSV 71

Query: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP---KPKGLQALRPPQVTPPRKDA 283
            PA+    S        +   P   G P  P  P+QP   K +     R  Q  P R   
Sbjct: 72  PPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGR--- 128

Query: 284 APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 343
           +P+   L  S   T       S   P  L  + +  A        +       +  S   
Sbjct: 129 SPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEE 188

Query: 344 SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ--APNALAVHLLQAPF 401
           +     +       P  +  PPLQ  P  P      P   P  Q   P +++    +   
Sbjct: 189 TTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIK 248

Query: 402 SPPPSP--PVQAPFSPP----ASPPVSPSATPPSQAP-------------PSLAAPPLQ- 441
           S PP    P+Q P   P    A  P+   A+ P                 PS + PP+Q 
Sbjct: 249 SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQ 308

Query: 442 -VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP---------PPQAPPALATPPLQA 491
             P  PPA  P    + P P  PP   A P  L KP         PP  PP    PP Q 
Sbjct: 309 PTPGKPPAQQPGHEKSQPGPAKPP---AQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP 365

Query: 492 L--PSPPASFPGQAPFSPSASLPMSPLATPPP-------QAPPVLAAPLLQV-PPSPPAS 541
           L    PPA   G     PS+  P       PP       Q P     P  QV  P P A 
Sbjct: 366 LGPAKPPAQQTGSE--KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423

Query: 542 -PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD-LAGHSSSATST 599
            P LQ+P + P         GP  T    PGP   P++      +GP   +   +  T  
Sbjct: 424 QPGLQSPAKAP---------GPTKTPVQQPGPGKIPAQQ-----AGPGKTSAQQTGPTKP 469

Query: 600 PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 659
           P +L G    P      + PP  +  +  P +   G   P   +  P  P P  P +   
Sbjct: 470 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS--- 526

Query: 660 SADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 709
                 T   ++ P SA P+     P         K  +  G+G   + P
Sbjct: 527 ------TKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 135/617 (21%), Positives = 206/617 (33%), Gaps = 86/617 (13%)

Query: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPP----PVTPAALRVLGA--AGAVGRKP 57
            K    + G+    P    P   +P+ PGS +PP        P+A +   A  +     KP
Sbjct: 498  KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557

Query: 58   LAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 117
            +++   G      P   P   P+   +PP+ G  +   P  NT+   +  P +A+  T  
Sbjct: 558  VSQTGSG-----KPLQPPTVSPS-AKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT-- 609

Query: 118  GPLGQKGLRISAEETVA-------RGKATEAPKRSALSAGARRDTSG---PTPGTPSPAM 167
                        + TV            TE  +   L+   +R   G   P P +P P +
Sbjct: 610  --------CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661

Query: 168  ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP---SPAARRRPSAGGG 224
                    + V    P P          P++ +S A E     P    P     PSA   
Sbjct: 662  KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA-KA 720

Query: 225  LQRPASRSLSSSATP----LSSPARSGPSARGTPRAP--AHPSQPKPKGLQALRPPQV-- 276
             Q P + SLS  A P    + S     P A   P+ P    P+        A   P +  
Sbjct: 721  KQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPS 780

Query: 277  TPPRKDAAPALGPLSSSPLATPSPSAPPSPS--APPSLQTLPSPPA-----TPPSQATTS 329
            +  +  A     P   +  A PS S PP+    +P   + +P P +     + P  ++ S
Sbjct: 781  SKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSES 840

Query: 330  LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 389
             G   +                +P P A P   +P  +  P+PP   P +    P+PQ  
Sbjct: 841  KGQKQVDPVQKKEEPKKAQTKMSPKPDAKP---MP--KGSPTPPGPRPTAGQTVPTPQ-- 893

Query: 390  NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
                    Q+P     S             P S   TP       L      +     AS
Sbjct: 894  --------QSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI--FSQAS 943

Query: 450  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPL---QALPSPPASFPGQAPFS 506
              +S +  P P +     AP  Q   P P  PP    PP    QA P+P  S P +    
Sbjct: 944  NLISTAGQPGPHSQSGPGAPMKQ--APAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETK 1001

Query: 507  PSASLPMSPLATPPP---------QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557
              A+  + P A   P         + PP+  +  L   P     PT    +   +P P++
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT----KLEKSPKPES 1057

Query: 558  SVSGPRLTLALAPGPPP 574
            +    +  L +    PP
Sbjct: 1058 TCPLCKTELNIGSKDPP 1074



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 80/310 (25%), Positives = 117/310 (37%), Gaps = 49/310 (15%)

Query: 306  PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365
            PS  PS+ +LP+ P   P   ++SL         S  P PP  P   PPP  PP      
Sbjct: 2377 PSGSPSVSSLPAKPR--PFFRSSSLDI-------SAQPPPPPPPPPPPPPPPPP------ 2421

Query: 366  LQAPPSPPASPPLSPLATPSPQ------APNALAVHLLQAPFSPPPSPPVQAPFSP---- 415
               PP PP  PP SP  T  P+      +P   A  L  A  +   +  +++   P    
Sbjct: 2422 ---PPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRI 2478

Query: 416  --PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQ 472
               A PPV P    PS  P  L       P  PP +P P+ P      Q P  +   P  
Sbjct: 2479 CTTAPPPVPPK---PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTG 2535

Query: 473  LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL 532
            L+         L T     LPSP       +P SP ++       + P  +  +    ++
Sbjct: 2536 LSLTSSMT-LNLVTSADYKLPSP------TSPLSPHSN------KSSPRFSKSLTETYVV 2582

Query: 533  QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLA 590
               PS P +PT  +  +  T  P  S S   +++    +  PP      P S+     ++
Sbjct: 2583 ITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYIS 2642

Query: 591  GHSSSATSTP 600
            G   + ++TP
Sbjct: 2643 GALQTFSATP 2652



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 62/211 (29%), Positives = 79/211 (37%), Gaps = 30/211 (14%)

Query: 416  PAS--PPVSPSATP-PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 472
            PAS  P  SPS +  P++  P   +  L +   PP  PP  P   PPP  PPP   PP  
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT 2431

Query: 473  LAKPP--PQAPPALATPPLQALPSPPA-SFPGQAPFSPSASLPMSPLAT--PPPQAPPVL 527
              KP   P+    +A+P   A P   A +         S  LP++ + T  PPP  P   
Sbjct: 2432 SPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPS 2491

Query: 528  AAPLLQV------PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG---------- 571
            + P   V      P  PP +P    P+ P T    T +      L+L             
Sbjct: 2492 SIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSAD 2551

Query: 572  ---PPPPPSRSPSSTLSGPDLAGHSSSATST 599
               P P    SP S  S P     S S T T
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRF---SKSLTET 2579



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/361 (23%), Positives = 129/361 (35%), Gaps = 68/361 (18%)

Query: 224  GLQRPASRSLSSSATPLSSPARSGP---------SARGTPRAPAHPSQPKPKGLQALRPP 274
            G ++PAS+  S S +  S PA+  P         SA+  P  P  P  P P       PP
Sbjct: 2368 GQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPP---PPPPPP 2424

Query: 275  QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 334
               PP     P + P     +A+P  +A P   A  +L+T            T  L S  
Sbjct: 2425 PPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET------------TAVLRSNG 2472

Query: 335  LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP-PLSPLATPSPQAP---- 389
            L  T     +PP  P+   P   P  L       P  PP +P P+ P    + Q P    
Sbjct: 2473 LPVTRICTTAPP--PVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIH 2530

Query: 390  ---------NALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSAT--------PPSQA 431
                     +++ ++L+ +     PSP    +P S  +SP  S S T        P    
Sbjct: 2531 PKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPG 2590

Query: 432  PPSLAAPPLQVPPSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPP----------QA 480
             P+ ++    +   P  SP     S  P     PP+ A  + ++               A
Sbjct: 2591 TPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSA 2650

Query: 481  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV-LAAPLLQVPPSPP 539
             P  A    QA P+    F        +  +  + ++     AP V L++  + +PP P 
Sbjct: 2651 TPVTAPSSFQAAPTSVTQF-------LTTEVSKTEVSATRSTAPSVGLSSISITIPPEPL 2703

Query: 540  A 540
            A
Sbjct: 2704 A 2704



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 81/339 (23%), Positives = 114/339 (33%), Gaps = 61/339 (17%)

Query: 243  PARSGPSARGTPRAPAHPSQPKP------KGLQALRPPQVTPPRKDAAPALGPLSSSPLA 296
            PA   PS  G+P   + P++P+P        + A  PP   PP                 
Sbjct: 2372 PASQLPS--GSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPP----------------- 2412

Query: 297  TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 356
             P P  PP P  PP L    SP  T   +   ++ SP   AT  F     L   A     
Sbjct: 2413 -PPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSN 2471

Query: 357  APPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 416
              P   +     PP PP      P + PS           L     P PS P      P 
Sbjct: 2472 GLPVTRICTTAPPPVPP-----KPSSIPSG----------LVFTHRPEPSKP------PI 2510

Query: 417  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
            A  PV P     +Q P  +   P  +  S  +S  ++   +   + P P +       K 
Sbjct: 2511 APKPVIPQLPTTTQKPTDIHPKPTGL--SLTSSMTLNLVTSADYKLPSPTSPLSPHSNKS 2568

Query: 477  PPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 535
             P+   +L  T  +  LPS P +       S S ++   PL +P        +  L+ V 
Sbjct: 2569 SPRFSKSLTETYVVITLPSEPGT---PTDSSASQAITSWPLGSP--------SKDLVSVE 2617

Query: 536  PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574
            P     P + A   P +      +SG   T +  P   P
Sbjct: 2618 PVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAP 2656



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 80/349 (22%), Positives = 115/349 (32%), Gaps = 54/349 (15%)

Query: 160  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS--------EHSTTEP 211
            P  P P     S     +   P P P   P PP   P   +   +        +   T  
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVA 2446

Query: 212  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 271
            SP     P          +  L S+  P++    + P     P  P  PS   P GL   
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSS-IPSGLVFT 2500

Query: 272  RPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS----APPSLQTLPSPPATPPSQAT 327
              P+ + P         P++  P+    P+    P+     P  L    S      + A 
Sbjct: 2501 HRPEPSKP---------PIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSAD 2551

Query: 328  TSLGSPTLQ-ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP 386
              L SPT   + HS   SP  S   T   +    + LP   + P  P     S   T  P
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRFSKSLT---ETYVVITLP---SEPGTPTDSSASQAITSWP 2605

Query: 387  QAPNALAVHLLQAPFS-PPPSPPVQAPFSPPASPPVSP-----SATPPSQAPPSLAAPP- 439
                +  +  ++  FS  PP   V+ P S   +  +S      SATP + AP S  A P 
Sbjct: 2606 LGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVT-APSSFQAAPT 2664

Query: 440  ------------LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
                         +V  +   +P +  S+      P PLA   + L KP
Sbjct: 2665 SVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKP 2713



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 39/126 (30%), Positives = 48/126 (38%), Gaps = 42/126 (33%)

Query: 475  KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 534
            KP  Q P    +P + +LP+ P       PF  S+SL +S  A PPP  PP         
Sbjct: 2371 KPASQLPSG--SPSVSSLPAKPR------PFFRSSSLDIS--AQPPPPPPP--------- 2411

Query: 535  PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 594
            PP PP          PP P P              P P PPP+    + L    L   S 
Sbjct: 2412 PPPPPP---------PPPPPP--------------PPPLPPPTSPKPTILPKKKLTVASP 2448

Query: 595  SATSTP 600
              T+TP
Sbjct: 2449 VTTATP 2454



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 84/363 (23%), Positives = 117/363 (32%), Gaps = 62/363 (17%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A+ P    P PP  P PPPP  P           +  K     A  +  AT    A   
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 78   GPT----RTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133
              T    R++  P +     APP     P P S P     T RP P              
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPP--VPPKPSSIPSGLVFTHRPEP-------------- 2505

Query: 134  ARGKATEAPKRSALSAGARRDTSGPTPGTPSP------AMARRSRAAGTEVGLPRPAPSA 187
               K   APK   +       T  PT   P P      +    +     +  LP P    
Sbjct: 2506 --SKPPIAPK--PVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPL 2561

Query: 188  RPRPPTEGPRKSVSSASEHST-TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 246
             P      PR S S    +   T PS           G    +S S + ++ PL SP++ 
Sbjct: 2562 SPHSNKSSPRFSKSLTETYVVITLPSEP---------GTPTDSSASQAITSWPLGSPSKD 2612

Query: 247  GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSP 306
              S       P     P    + A+  P  +      + AL   S++P+  PS       
Sbjct: 2613 LVSVE-----PVFSVVPP---VTAVEIPISSEQTFYISGALQTFSATPVTAPS------- 2657

Query: 307  SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 366
                   +  + P +     TT +    + AT S  PS  LS ++   P  P AL    L
Sbjct: 2658 -------SFQAAPTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHL 2710

Query: 367  QAP 369
            + P
Sbjct: 2711 EKP 2713



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 38/141 (26%), Positives = 55/141 (39%), Gaps = 10/141 (7%)

Query: 367  QAPPSPPASPPLSPLATPSP----QAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPV 421
            Q+P    A+ P      P+P     + +  A   +Q   SPP SP V  +P SP +    
Sbjct: 3576 QSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKA 3635

Query: 422  SPSATPPSQAP-PSLAAPPLQVPPS----PPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
              SA  P + P P   +P   + P     PPASP  +         P PL+    + ++ 
Sbjct: 3636 LESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRA 3695

Query: 477  PPQAPPALATPPLQALPSPPA 497
            P Q      T   Q + S  A
Sbjct: 3696 PFQYTEGYTTKGSQTMTSSGA 3716



 Score = 33.5 bits (75), Expect = 0.82
 Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 3/125 (2%)

Query: 402  SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 461
            S   SP   +  SPP      P+      +    A   +Q+ PSPP SP +  S   P  
Sbjct: 3573 SDTQSPQYLSATSPPKDKK-RPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLS 3631

Query: 462  APPPLAAPPLQLAKPPPQ--APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519
                L +  +   KP P   +P  +  P +  +P            S S   P+SP A  
Sbjct: 3632 PGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADE 3691

Query: 520  PPQAP 524
              +AP
Sbjct: 3692 SSRAP 3696



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 12/132 (9%)

Query: 305  SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364
            S +  P   +  SPP          +G        S L +     LA  PP++P  L  P
Sbjct: 3573 SDTQSPQYLSATSPPKDKKRPTPLEIGYS------SHLRADSTVQLAPSPPKSPKVLYSP 3626

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP----VQAPFSPPASPP 420
                 P         P   P P   +   V        PP SP     +Q   S P   P
Sbjct: 3627 ISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP--KP 3684

Query: 421  VSPSATPPSQAP 432
            +SP+A   S+AP
Sbjct: 3685 LSPTADESSRAP 3696


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score =  124 bits (312), Expect = 3e-28
 Identities = 155/606 (25%), Positives = 222/606 (36%), Gaps = 97/606 (16%)

Query: 31  GSPRPPPPVTPAALRV-LGAAGAVGRKPLA---ERAGGIGGATIPESAPRAG-------- 78
           G+  P     PA +   L       R+ +A    RA G+   ++P +A  +         
Sbjct: 28  GAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQEL 87

Query: 79  -----PTRTSRPPASGRGERAPPAKNTSPGPVSS----PGRASGT-TRPGPLGQKGLRIS 128
                P ++ RPP  GR  +   +K+ +     S    PGR+  T +      +  L+  
Sbjct: 88  DSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEE 147

Query: 129 AEETVARGKATEAPKRSALSAGARR----DTSGPTPGTPSPAMARRSRAAGTEVGLPR-- 182
            + ++  G  +E    SA+S+   +    D    +  +      ++ +    E G P   
Sbjct: 148 HKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEET-TKKQKVVQKEQGKPEGI 206

Query: 183 ---------PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233
                    P P  + + P   P +   +    S+ +P     + P  G  +Q P     
Sbjct: 207 IKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQ 266

Query: 234 SSSAT-PLSSPA-----RSGPSARGTPRAPAHPSQPKPKGLQAL--RPPQVTPPRKDAAP 285
           +  A  PL   A     +     RG    P+ PS  KP   Q    +PP   P  + + P
Sbjct: 267 TDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326

Query: 286 ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT--PPSQATTSLGSPTLQATHSFLP 343
             GP  + P A PS    P    P +++    PP T  PP+Q       P  Q T S  P
Sbjct: 327 --GP--AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKP 381

Query: 344 SPPLSPLATPPPQA---PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 400
           S        P P+A   PP +   P Q P   PA PP   + TP P A         +AP
Sbjct: 382 SSE-----QPGPKALAQPPGVGKTPAQQPG--PAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 401 FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 460
              P   PVQ P          P   P  QA P   +     P  PP+  P    A PPP
Sbjct: 435 --GPTKTPVQQP---------GPGKIPAQQAGPGKTSAQQTGPTKPPSQLP--GPAKPPP 481

Query: 461 QAPPPLAAPPLQ--LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLAT 518
           Q P P   PP Q   AKPP Q P +   PP Q  P+ P+              P  P +T
Sbjct: 482 QQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS--------------PQQPGST 527

Query: 519 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 578
            PP   P  A P  Q P   PA P+ Q   +P +    T    P     ++P    PPS+
Sbjct: 528 KPPSQQPGSAKPSAQQPS--PAKPSAQQSTKPVS---QTGSGKPLQPPTVSPSAKQPPSQ 582

Query: 579 SPSSTL 584
               T+
Sbjct: 583 GLPKTI 588



 Score =  113 bits (282), Expect = 8e-25
 Identities = 176/718 (24%), Positives = 256/718 (35%), Gaps = 126/718 (17%)

Query: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRP--PPPVTPAALRVLGAAGAVGRKPLAERA 62
           RD  +     ++ +++ P  +  +PPG+ +P   P  TP              +P  ++A
Sbjct: 227 RDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQA 286

Query: 63  GGIGGATI------PESAPRAGPTRTSRPPA-------SGRGERAPPAKNTS-------- 101
             + G ++      P   P   PT   +PPA       S  G   PPA+ +         
Sbjct: 287 DIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQ 345

Query: 102 PGPVSSPGRASGTTRPG--PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 159
           PG V  P +  GTT+P   PLG    +  A++T +   ++E P   AL   A+    G T
Sbjct: 346 PGTVKPPVQPPGTTKPPAQPLGPA--KPPAQQTGSEKPSSEQPGPKAL---AQPPGVGKT 400

Query: 160 PGT-PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 218
           P   P PA     +    +VG P+P      +P  + P K+    ++    +P P     
Sbjct: 401 PAQQPGPA-----KPPTQQVGTPKPLAQ---QPGLQSPAKA-PGPTKTPVQQPGPGKIPA 451

Query: 219 PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 278
             AG G         +   + L  PA+  P   G  + P  P QP      + +P    P
Sbjct: 452 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQQPGSTKP 509

Query: 279 PRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338
           P +   PA  P    P +T  PS  P  SA PS Q  PSP A P +Q +T   S T   +
Sbjct: 510 PPQQPGPAK-PSPQQPGSTKPPSQQPG-SAKPSAQQ-PSP-AKPSAQQSTKPVSQT--GS 563

Query: 339 HSFLPSPPLSPLATPPP-QAPPALALPPLQAPPSPPASPPLSPLAT-------------- 383
              L  P +SP A  PP Q  P    P           P  +   T              
Sbjct: 564 GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGF 623

Query: 384 -PSPQAP--------NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 434
            P+P           N      L    +P PS P     + P +   + S + P      
Sbjct: 624 NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQ----- 678

Query: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA------APPLQLAKPPPQ-------AP 481
               P Q  P   A+P    S  P P+ PPPL         P   AK PP+       AP
Sbjct: 679 ----PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAP 734

Query: 482 PALATPPLQALPSPPASFPGQAP--FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 539
           P   + P +   +P A    + P    P+  L  S  AT  P  P        +   +PP
Sbjct: 735 PKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPP 794

Query: 540 ASPTLQAPRR--PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597
                  P +  PPT        G +++   +   P P S S   +  GP      S   
Sbjct: 795 LKTDSAKPSQSFPPT--------GEKVSPFDSKAIPRPASDSKIISHPGP---SSESKGQ 843

Query: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA 655
              + ++  +   +     SP PDA+            P P    +G+P  P P P A
Sbjct: 844 KQVDPVQKKEEPKKAQTKMSPKPDAK------------PMP----KGSPTPPGPRPTA 885



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/746 (23%), Positives = 268/746 (35%), Gaps = 154/746 (20%)

Query: 17   PAARAPGLLTP--RPPGSPRPPP-PVTPAALRVLGAAGAVGRKPLAERAG--------GI 65
            P A+ PG + P  +PPG+ +PP  P+ PA      A      KP +E+ G        G+
Sbjct: 341  PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP---AQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 66   GGATIPESAPRAGPTR---TSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG--PL 120
            G     +  P   PT+   T +P A   G ++P     +PGP  +P +  G   PG  P 
Sbjct: 398  GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAK---APGPTKTPVQQPG---PGKIPA 451

Query: 121  GQKGL-RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG 179
             Q G  + SA++T      T+ P  S L   A+     P P  P P     ++    + G
Sbjct: 452  QQAGPGKTSAQQT----GPTKPP--SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505

Query: 180  LPRPAPS----ARP--------RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 227
              +P P     A+P        +PP++ P  +  SA + S  +PS     +P +  G  +
Sbjct: 506  STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGK 565

Query: 228  PASRSLSSSATPLSSPARSGPSARGTPRA---------------------PAHPSQPKPK 266
            P          P  SP+   P ++G P+                           Q    
Sbjct: 566  PLQ-------PPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVC 618

Query: 267  GLQALRP-PQVTPPRK--------------DAAPALGP----LSSSPLATPSPSAPPSPS 307
             L    P P +T  ++              D AP        L ++P+ T S     S S
Sbjct: 619  SLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTS---AVSKS 675

Query: 308  APPSLQTLPSPPATPP---SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364
            +P   QT P   A P    S+A      P L    +   SP  S  A  PP+A  +L+ P
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP--SAKAKQPPEA-DSLSKP 732

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNAL-----AVHLLQAPFSPP-PSPPVQAPFSPPAS 418
                 PS P+    +P+A   P+ P  +      V    A   P  PS  VQ+      +
Sbjct: 733  APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTT 792

Query: 419  PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP 478
            PP+   +  PSQ+           PP+     P    A P P +   + + P     P  
Sbjct: 793  PPLKTDSAKPSQS----------FPPTGEKVSPFDSKAIPRPASDSKIISHP----GPSS 838

Query: 479  QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
            ++       P+Q    P  +   Q   SP       P  +P P              P P
Sbjct: 839  ESKGQKQVDPVQKKEEPKKA---QTKMSPKPDAKPMPKGSPTPPG------------PRP 883

Query: 539  PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR--SPSSTLSGPDLAGHSSSA 596
             A  T+  P++ P P   +     R +L L      P S+  +P  T++G  L G  +S 
Sbjct: 884  TAGQTVPTPQQSPKPQEQSR----RFSLNLGSITDAPKSQPTTPQETVTG-KLFGFGASI 938

Query: 597  TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656
             S    L           A  P P ++     P   +  P+ P   +G P +    PPA 
Sbjct: 939  FSQASNLI--------STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA- 989

Query: 657  GPGSADGLCTIYETEGPESATPAPGA 682
                A  +    ET+ P +    P A
Sbjct: 990  ---PAKSIPVKKETKAPAAEKLEPKA 1012



 Score =  108 bits (269), Expect = 3e-23
 Identities = 188/766 (24%), Positives = 264/766 (34%), Gaps = 132/766 (17%)

Query: 28  RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRT-SRPP 86
           +PP   +PP P+              GR PL +          P+S     P +  S+PP
Sbjct: 208 KPPLQQQPPKPIPKQQ--------GPGRDPLQQDG-------TPKSISSQQPEKIKSQPP 252

Query: 87  ASGRGERAPPAKNTSPGPVSSPGRASGTTRPG-PLGQKGLRISAEET-VARGKATEAPKR 144
            +G+             P+  P +   T     PL +   R   ++  + RG++     +
Sbjct: 253 GTGK-------------PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV----K 295

Query: 145 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA-----PSARPRPPTEGPRKS 199
            +L + ++     PTPG P       ++  G E   P PA     PS   +P  + P   
Sbjct: 296 PSLPSPSKPPIQQPTPGKPP------AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV 349

Query: 200 VSSASEHSTTEP--SPAARRRPSAGG-GLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256
                   TT+P   P    +P A   G ++P+S      A  L+ P    P    TP  
Sbjct: 350 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKA--LAQP----PGVGKTPAQ 403

Query: 257 PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316
              P++P  + +   +P    P  +  A A GP + +P+  P P   P+  A P   +  
Sbjct: 404 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP-TKTPVQQPGPGKIPAQQAGPGKTSAQ 462

Query: 317 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP 376
               T P         P  Q      P P     A PP Q P +   PP Q  P+ P+  
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS-- 520

Query: 377 PLSPLATPSPQAPNALAVHLLQAPFSPPPS------PPVQAPFSPPASPP-VSPSA-TPP 428
           P  P +T  P      A    Q P    PS      P  Q     P  PP VSPSA  PP
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP 580

Query: 429 SQAPPSLAAP-------PLQVPPSPPASPPMSPSAT--------PPPQAP---------- 463
           SQ  P    P        L VP     +       T        P P             
Sbjct: 581 SQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNC 640

Query: 464 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA-SLPMSPL--ATPP 520
               A    LA  P    P L T P+    +   S P     SP   + P   L  A  P
Sbjct: 641 QMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEP 700

Query: 521 PQAPPVLAAPLLQVPPS-----PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575
            + PP++  P L   PS     PP + +L  P  P  P    SV   +    +A   P  
Sbjct: 701 KKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEP----SVPSEQDKAPVADDKPKQ 756

Query: 576 PSR--------SPSSTLSGPDLAG---HSSSATSTPEELRGYDSGPEGGAAASPPPDAEL 624
           P          S SS  + PD+      S +   T   L+   + P    + S PP  E 
Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEK 812

Query: 625 AACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESA----TPAP 680
            +   +     PA        PG   P   + G    D    + + E P+ A    +P P
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPG---PSSESKGQKQVD---PVQKKEEPKKAQTKMSPKP 866

Query: 681 GALD-PGPSPGTSGGKAAAGAGAGASSRSPK---QARLGELPLGAL 722
            A   P  SP   G +  AG       +SPK   Q+R   L LG++
Sbjct: 867 DAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912



 Score =  105 bits (262), Expect = 2e-22
 Identities = 108/408 (26%), Positives = 146/408 (35%), Gaps = 49/408 (12%)

Query: 199 SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258
           S S AS+  TT+     ++      G+ +P  +           P +  P  +G  R P 
Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ---------QPPKPIPKQQGPGRDPL 230

Query: 259 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP 318
                 PK + + +P ++    K   P  G     P  TP       P     LQ   S 
Sbjct: 231 Q-QDGTPKSISSQQPEKI----KSQPPGTGKPIQGPTQTPQTDHAKLP-----LQRDASR 280

Query: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378
           P T   QA    G    ++    LPSP   P+  P P  PPA      ++ P P A PP 
Sbjct: 281 PQT--KQADIVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGP-AKPPA 333

Query: 379 SP--LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436
            P  L  P  Q P  +   +     + PP+ P+  P  PPA    S   +     P +LA
Sbjct: 334 QPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL-GPAKPPAQQTGSEKPSSEQPGPKALA 392

Query: 437 APPLQVPPSP-----PASPPMSPSATPPPQAPPPLAAPPLQLAKP---PPQAPPALATPP 488
            PP  V  +P     PA PP     TP P A  P    P +   P   P Q P     P 
Sbjct: 393 QPP-GVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPA 451

Query: 489 LQALPS-----------PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS 537
            QA P            PP+  PG A   P    P  P    P  A P    P    PP 
Sbjct: 452 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPP 511

Query: 538 PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
               P   +P++P +  P +   G     A  P P  P ++  +  +S
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 141/590 (23%), Positives = 192/590 (32%), Gaps = 82/590 (13%)

Query: 167 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 226
           +A  + A G   G   P+ +A P     G    +S  SE    + +    R      G  
Sbjct: 16  LAAAAAAGGGASGAGSPSHTAIPA----GMEADLSQLSEEERRQIAAVMSRAQGLPKGSV 71

Query: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP---KPKGLQALRPPQVTPPRKDA 283
            PA+    S        +   P   G P  P  P+QP   K +     R  Q  P R   
Sbjct: 72  PPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGR--- 128

Query: 284 APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 343
           +P+   L  S   T       S   P  L  + +  A        +       +  S   
Sbjct: 129 SPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEE 188

Query: 344 SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ--APNALAVHLLQAPF 401
           +     +       P  +  PPLQ  P  P      P   P  Q   P +++    +   
Sbjct: 189 TTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIK 248

Query: 402 SPPPSP--PVQAPFSPP----ASPPVSPSATPPSQAP-------------PSLAAPPLQ- 441
           S PP    P+Q P   P    A  P+   A+ P                 PS + PP+Q 
Sbjct: 249 SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQ 308

Query: 442 -VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP---------PPQAPPALATPPLQA 491
             P  PPA  P    + P P  PP   A P  L KP         PP  PP    PP Q 
Sbjct: 309 PTPGKPPAQQPGHEKSQPGPAKPP---AQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP 365

Query: 492 L--PSPPASFPGQAPFSPSASLPMSPLATPPP-------QAPPVLAAPLLQV-PPSPPAS 541
           L    PPA   G     PS+  P       PP       Q P     P  QV  P P A 
Sbjct: 366 LGPAKPPAQQTGSE--KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423

Query: 542 -PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD-LAGHSSSATST 599
            P LQ+P + P         GP  T    PGP   P++      +GP   +   +  T  
Sbjct: 424 QPGLQSPAKAP---------GPTKTPVQQPGPGKIPAQQ-----AGPGKTSAQQTGPTKP 469

Query: 600 PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 659
           P +L G    P      + PP  +  +  P +   G   P   +  P  P P  P +   
Sbjct: 470 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS--- 526

Query: 660 SADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 709
                 T   ++ P SA P+     P         K  +  G+G   + P
Sbjct: 527 ------TKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 135/617 (21%), Positives = 206/617 (33%), Gaps = 86/617 (13%)

Query: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPP----PVTPAALRVLGA--AGAVGRKP 57
            K    + G+    P    P   +P+ PGS +PP        P+A +   A  +     KP
Sbjct: 498  KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557

Query: 58   LAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 117
            +++   G      P   P   P+   +PP+ G  +   P  NT+   +  P +A+  T  
Sbjct: 558  VSQTGSG-----KPLQPPTVSPS-AKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT-- 609

Query: 118  GPLGQKGLRISAEETVA-------RGKATEAPKRSALSAGARRDTSG---PTPGTPSPAM 167
                        + TV            TE  +   L+   +R   G   P P +P P +
Sbjct: 610  --------CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661

Query: 168  ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP---SPAARRRPSAGGG 224
                    + V    P P          P++ +S A E     P    P     PSA   
Sbjct: 662  KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA-KA 720

Query: 225  LQRPASRSLSSSATP----LSSPARSGPSARGTPRAP--AHPSQPKPKGLQALRPPQV-- 276
             Q P + SLS  A P    + S     P A   P+ P    P+        A   P +  
Sbjct: 721  KQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPS 780

Query: 277  TPPRKDAAPALGPLSSSPLATPSPSAPPSPS--APPSLQTLPSPPA-----TPPSQATTS 329
            +  +  A     P   +  A PS S PP+    +P   + +P P +     + P  ++ S
Sbjct: 781  SKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSES 840

Query: 330  LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 389
             G   +                +P P A P   +P  +  P+PP   P +    P+PQ  
Sbjct: 841  KGQKQVDPVQKKEEPKKAQTKMSPKPDAKP---MP--KGSPTPPGPRPTAGQTVPTPQ-- 893

Query: 390  NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449
                    Q+P     S             P S   TP       L      +     AS
Sbjct: 894  --------QSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI--FSQAS 943

Query: 450  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPL---QALPSPPASFPGQAPFS 506
              +S +  P P +     AP  Q   P P  PP    PP    QA P+P  S P +    
Sbjct: 944  NLISTAGQPGPHSQSGPGAPMKQ--APAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETK 1001

Query: 507  PSASLPMSPLATPPP---------QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557
              A+  + P A   P         + PP+  +  L   P     PT    +   +P P++
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT----KLEKSPKPES 1057

Query: 558  SVSGPRLTLALAPGPPP 574
            +    +  L +    PP
Sbjct: 1058 TCPLCKTELNIGSKDPP 1074



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 80/310 (25%), Positives = 117/310 (37%), Gaps = 49/310 (15%)

Query: 306  PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365
            PS  PS+ +LP+ P   P   ++SL         S  P PP  P   PPP  PP      
Sbjct: 2377 PSGSPSVSSLPAKPR--PFFRSSSLDI-------SAQPPPPPPPPPPPPPPPPP------ 2421

Query: 366  LQAPPSPPASPPLSPLATPSPQ------APNALAVHLLQAPFSPPPSPPVQAPFSP---- 415
               PP PP  PP SP  T  P+      +P   A  L  A  +   +  +++   P    
Sbjct: 2422 ---PPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRI 2478

Query: 416  --PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQ 472
               A PPV P    PS  P  L       P  PP +P P+ P      Q P  +   P  
Sbjct: 2479 CTTAPPPVPPK---PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTG 2535

Query: 473  LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL 532
            L+         L T     LPSP       +P SP ++       + P  +  +    ++
Sbjct: 2536 LSLTSSMT-LNLVTSADYKLPSP------TSPLSPHSN------KSSPRFSKSLTETYVV 2582

Query: 533  QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLA 590
               PS P +PT  +  +  T  P  S S   +++    +  PP      P S+     ++
Sbjct: 2583 ITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYIS 2642

Query: 591  GHSSSATSTP 600
            G   + ++TP
Sbjct: 2643 GALQTFSATP 2652



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 62/211 (29%), Positives = 79/211 (37%), Gaps = 30/211 (14%)

Query: 416  PAS--PPVSPSATP-PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 472
            PAS  P  SPS +  P++  P   +  L +   PP  PP  P   PPP  PPP   PP  
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT 2431

Query: 473  LAKPP--PQAPPALATPPLQALPSPPA-SFPGQAPFSPSASLPMSPLAT--PPPQAPPVL 527
              KP   P+    +A+P   A P   A +         S  LP++ + T  PPP  P   
Sbjct: 2432 SPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPS 2491

Query: 528  AAPLLQV------PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG---------- 571
            + P   V      P  PP +P    P+ P T    T +      L+L             
Sbjct: 2492 SIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSAD 2551

Query: 572  ---PPPPPSRSPSSTLSGPDLAGHSSSATST 599
               P P    SP S  S P     S S T T
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRF---SKSLTET 2579



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/361 (23%), Positives = 129/361 (35%), Gaps = 68/361 (18%)

Query: 224  GLQRPASRSLSSSATPLSSPARSGP---------SARGTPRAPAHPSQPKPKGLQALRPP 274
            G ++PAS+  S S +  S PA+  P         SA+  P  P  P  P P       PP
Sbjct: 2368 GQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPP---PPPPPP 2424

Query: 275  QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 334
               PP     P + P     +A+P  +A P   A  +L+T            T  L S  
Sbjct: 2425 PPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET------------TAVLRSNG 2472

Query: 335  LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP-PLSPLATPSPQAP---- 389
            L  T     +PP  P+   P   P  L       P  PP +P P+ P    + Q P    
Sbjct: 2473 LPVTRICTTAPP--PVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIH 2530

Query: 390  ---------NALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSAT--------PPSQA 431
                     +++ ++L+ +     PSP    +P S  +SP  S S T        P    
Sbjct: 2531 PKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPG 2590

Query: 432  PPSLAAPPLQVPPSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPP----------QA 480
             P+ ++    +   P  SP     S  P     PP+ A  + ++               A
Sbjct: 2591 TPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSA 2650

Query: 481  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV-LAAPLLQVPPSPP 539
             P  A    QA P+    F        +  +  + ++     AP V L++  + +PP P 
Sbjct: 2651 TPVTAPSSFQAAPTSVTQF-------LTTEVSKTEVSATRSTAPSVGLSSISITIPPEPL 2703

Query: 540  A 540
            A
Sbjct: 2704 A 2704



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 81/339 (23%), Positives = 114/339 (33%), Gaps = 61/339 (17%)

Query: 243  PARSGPSARGTPRAPAHPSQPKP------KGLQALRPPQVTPPRKDAAPALGPLSSSPLA 296
            PA   PS  G+P   + P++P+P        + A  PP   PP                 
Sbjct: 2372 PASQLPS--GSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPP----------------- 2412

Query: 297  TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 356
             P P  PP P  PP L    SP  T   +   ++ SP   AT  F     L   A     
Sbjct: 2413 -PPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSN 2471

Query: 357  APPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 416
              P   +     PP PP      P + PS           L     P PS P      P 
Sbjct: 2472 GLPVTRICTTAPPPVPP-----KPSSIPSG----------LVFTHRPEPSKP------PI 2510

Query: 417  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
            A  PV P     +Q P  +   P  +  S  +S  ++   +   + P P +       K 
Sbjct: 2511 APKPVIPQLPTTTQKPTDIHPKPTGL--SLTSSMTLNLVTSADYKLPSPTSPLSPHSNKS 2568

Query: 477  PPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 535
             P+   +L  T  +  LPS P +       S S ++   PL +P        +  L+ V 
Sbjct: 2569 SPRFSKSLTETYVVITLPSEPGT---PTDSSASQAITSWPLGSP--------SKDLVSVE 2617

Query: 536  PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574
            P     P + A   P +      +SG   T +  P   P
Sbjct: 2618 PVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAP 2656



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 80/349 (22%), Positives = 115/349 (32%), Gaps = 54/349 (15%)

Query: 160  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS--------EHSTTEP 211
            P  P P     S     +   P P P   P PP   P   +   +        +   T  
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVA 2446

Query: 212  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 271
            SP     P          +  L S+  P++    + P     P  P  PS   P GL   
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSS-IPSGLVFT 2500

Query: 272  RPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS----APPSLQTLPSPPATPPSQAT 327
              P+ + P         P++  P+    P+    P+     P  L    S      + A 
Sbjct: 2501 HRPEPSKP---------PIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSAD 2551

Query: 328  TSLGSPTLQ-ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP 386
              L SPT   + HS   SP  S   T   +    + LP   + P  P     S   T  P
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRFSKSLT---ETYVVITLP---SEPGTPTDSSASQAITSWP 2605

Query: 387  QAPNALAVHLLQAPFS-PPPSPPVQAPFSPPASPPVSP-----SATPPSQAPPSLAAPP- 439
                +  +  ++  FS  PP   V+ P S   +  +S      SATP + AP S  A P 
Sbjct: 2606 LGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVT-APSSFQAAPT 2664

Query: 440  ------------LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
                         +V  +   +P +  S+      P PLA   + L KP
Sbjct: 2665 SVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKP 2713



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 39/126 (30%), Positives = 48/126 (38%), Gaps = 42/126 (33%)

Query: 475  KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 534
            KP  Q P    +P + +LP+ P       PF  S+SL +S  A PPP  PP         
Sbjct: 2371 KPASQLPSG--SPSVSSLPAKPR------PFFRSSSLDIS--AQPPPPPPP--------- 2411

Query: 535  PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 594
            PP PP          PP P P              P P PPP+    + L    L   S 
Sbjct: 2412 PPPPPP---------PPPPPP--------------PPPLPPPTSPKPTILPKKKLTVASP 2448

Query: 595  SATSTP 600
              T+TP
Sbjct: 2449 VTTATP 2454



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 84/363 (23%), Positives = 117/363 (32%), Gaps = 62/363 (17%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A+ P    P PP  P PPPP  P           +  K     A  +  AT    A   
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 78   GPT----RTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133
              T    R++  P +     APP     P P S P     T RP P              
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPP--VPPKPSSIPSGLVFTHRPEP-------------- 2505

Query: 134  ARGKATEAPKRSALSAGARRDTSGPTPGTPSP------AMARRSRAAGTEVGLPRPAPSA 187
               K   APK   +       T  PT   P P      +    +     +  LP P    
Sbjct: 2506 --SKPPIAPK--PVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPL 2561

Query: 188  RPRPPTEGPRKSVSSASEHST-TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 246
             P      PR S S    +   T PS           G    +S S + ++ PL SP++ 
Sbjct: 2562 SPHSNKSSPRFSKSLTETYVVITLPSEP---------GTPTDSSASQAITSWPLGSPSKD 2612

Query: 247  GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSP 306
              S       P     P    + A+  P  +      + AL   S++P+  PS       
Sbjct: 2613 LVSVE-----PVFSVVPP---VTAVEIPISSEQTFYISGALQTFSATPVTAPS------- 2657

Query: 307  SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 366
                   +  + P +     TT +    + AT S  PS  LS ++   P  P AL    L
Sbjct: 2658 -------SFQAAPTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHL 2710

Query: 367  QAP 369
            + P
Sbjct: 2711 EKP 2713



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 38/141 (26%), Positives = 55/141 (39%), Gaps = 10/141 (7%)

Query: 367  QAPPSPPASPPLSPLATPSP----QAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPV 421
            Q+P    A+ P      P+P     + +  A   +Q   SPP SP V  +P SP +    
Sbjct: 3576 QSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKA 3635

Query: 422  SPSATPPSQAP-PSLAAPPLQVPPS----PPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476
              SA  P + P P   +P   + P     PPASP  +         P PL+    + ++ 
Sbjct: 3636 LESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRA 3695

Query: 477  PPQAPPALATPPLQALPSPPA 497
            P Q      T   Q + S  A
Sbjct: 3696 PFQYTEGYTTKGSQTMTSSGA 3716



 Score = 33.5 bits (75), Expect = 0.82
 Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 3/125 (2%)

Query: 402  SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 461
            S   SP   +  SPP      P+      +    A   +Q+ PSPP SP +  S   P  
Sbjct: 3573 SDTQSPQYLSATSPPKDKK-RPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLS 3631

Query: 462  APPPLAAPPLQLAKPPPQ--APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519
                L +  +   KP P   +P  +  P +  +P            S S   P+SP A  
Sbjct: 3632 PGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADE 3691

Query: 520  PPQAP 524
              +AP
Sbjct: 3692 SSRAP 3696



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 12/132 (9%)

Query: 305  SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364
            S +  P   +  SPP          +G        S L +     LA  PP++P  L  P
Sbjct: 3573 SDTQSPQYLSATSPPKDKKRPTPLEIGYS------SHLRADSTVQLAPSPPKSPKVLYSP 3626

Query: 365  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP----VQAPFSPPASPP 420
                 P         P   P P   +   V        PP SP     +Q   S P   P
Sbjct: 3627 ISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP--KP 3684

Query: 421  VSPSATPPSQAP 432
            +SP+A   S+AP
Sbjct: 3685 LSPTADESSRAP 3696


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score =  124 bits (311), Expect = 4e-28
 Identities = 207/833 (24%), Positives = 258/833 (30%), Gaps = 157/833 (18%)

Query: 7   KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPV-----------------TPAALRVLGA 49
           +  AG   R      PGL  P PPG P PP P                  +   + V G 
Sbjct: 123 RGPAGPPGRDGIPGQPGL--PGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP 180

Query: 50  AGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASG----RGERAPPAKNTSPGPV 105
            G  G + L     G  GA  P+   +  P     P ASG    RG   PP KN   G  
Sbjct: 181 MGPSGPRGLP----GPPGAPGPQGF-QGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEA 235

Query: 106 SSPGRASGTTRPGPLGQKGLRISAEETVARG----KATEAPKRSALSAGARRDTSGP--- 158
             PGR      PGP G +GL  +A     +G       +  K  A  AG + +   P   
Sbjct: 236 GKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGEN 295

Query: 159 ----------------TPGTPSPAMARRSRAAGTEVGLPRP-----------APSARPRP 191
                            PG P PA AR +  A    G P P           A  A+   
Sbjct: 296 GAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEA 355

Query: 192 PTEGPRKSVSSASEHSTT-EPSPAARRRPSAGGGLQ-RPASRSLSSSATPLSSPARSGPS 249
             +GPR S            P PA    P+   G   +P ++  + +     +P   G  
Sbjct: 356 GPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGAR 415

Query: 250 ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAP 309
               P+ P  P  P PKG          P  K    A G     P+    P  P      
Sbjct: 416 GPSGPQGPGGP--PGPKGNSG---EPGAPGSKGDTGAKG--EPGPVGVQGPPGPAGEEGK 468

Query: 310 PSLQTLPSPPAT--PPSQ--ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA----- 360
              +  P P     PP +     S G P         P  P     +P P  P       
Sbjct: 469 RGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAG--PKGPAGERGSPGPAGPKGSPGEA 526

Query: 361 -----LALPPLQAPPSPPASP-PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 414
                  LP  +     P SP P      P P   +            PP  P  +    
Sbjct: 527 GRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRP--------GPPGPPGARGQAG 578

Query: 415 PPASPPVSPSATPPSQA-------PPSLAAPP-------LQVPPSP--PASP--PMSPSA 456
               P    +A  P +A       PP    P         Q PP P  PA       P+ 
Sbjct: 579 VMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAG 638

Query: 457 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS--PSASLPMS 514
           +P  Q  P  A PP +  KP  Q  P     P  +       FPG+      P  + P  
Sbjct: 639 SPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRG 698

Query: 515 PLATP----------PPQAPPVLAAPLLQVPPSPPASPTLQAPR----------RPPTPG 554
               P           P AP    AP LQ  P    +  L  P+             +PG
Sbjct: 699 ANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPG 758

Query: 555 PD--TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612
            D    ++GP        GPP P         SGP      + A   P + RG + GP G
Sbjct: 759 KDGVRGLTGP-------IGPPGPAGAPGDKGESGPSGPAGPTGARGAPGD-RG-EPGPPG 809

Query: 613 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG-----SADGLCTI 667
            A  + PP A+     P A  +G       +G  G P P  PA  PG      A G    
Sbjct: 810 PAGFAGPPGAD---GQPGA--KGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGA 864

Query: 668 YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLG 720
             + GP  AT  PGA      PG SG     G    A     K  R    P G
Sbjct: 865 RGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAG 917



 Score =  118 bits (295), Expect = 3e-26
 Identities = 213/812 (26%), Positives = 256/812 (31%), Gaps = 143/812 (17%)

Query: 21   APGLLTPRP-PGSPRPPPPVTPAALR----VLGAAGAVGRKPLAERAGGIGGATIPESAP 75
            APG + PR  PG    P    PA  R      GAAG  G    A   G  G       A 
Sbjct: 297  APGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAG 356

Query: 76   RAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 135
              GP R S  P   RGE  PP    + GP  +PG        G  G  G+  +     AR
Sbjct: 357  PQGP-RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGAR 415

Query: 136  GKA-------TEAPKRSALSAGA---RRDTSG---PTP----GTPSPAMARRSRAAGTE- 177
            G +          PK ++   GA   + DT     P P    G P PA     R A  E 
Sbjct: 416  GPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEP 475

Query: 178  --VGLPRP-----APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 230
               GLP P      P +R  P  +G       A E  +  P PA  +      G  RP  
Sbjct: 476  GPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGS--PGPAGPKGSPGEAG--RPGE 531

Query: 231  RSLSSSATPLSSPARSGPSARGTPRAPA----HPSQPKPKGLQALRPPQVTPPRKDAAP- 285
              L  +     SP   GP  +  P  PA     P  P P G +        P  K AA  
Sbjct: 532  AGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGE 591

Query: 286  --------------ALGPLSSSPLA----TPSPSAPPS------PSAPPSLQTLPSPPAT 321
                          A+GP      A     P P+ P        P+  P  Q LP P A 
Sbjct: 592  PGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGP-AG 650

Query: 322  PPSQATT--------SLGSPTLQATHSFLPSPPLSPLATPP------------------- 354
            PP +A           LG+P           P    +  PP                   
Sbjct: 651  PPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKG 710

Query: 355  ----PQAPPALALPPLQAPPSPPASP----PLSPLATPSPQ----APNALAVHLLQAPFS 402
                P AP +   P LQ  P    +     P        P+    +P    V  L  P  
Sbjct: 711  DAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIG 770

Query: 403  PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 462
            PP   P  AP     S P  P+    ++  P     P    P+  A PP +     P   
Sbjct: 771  PPG--PAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQ--PGAK 826

Query: 463  PPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 522
              P  A     A PP  A PA    P+  + +P A     +   P A+          P 
Sbjct: 827  GEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPP 886

Query: 523  APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 582
             P   A P    PP P      + PR    P       GP       PGPP P     S 
Sbjct: 887  GPSGNAGP--PGPPGPAGKEGGKGPRGETGPAGRPGEVGP-------PGPPGPAGEKGSP 937

Query: 583  TLSGPDLAGHSSSATSTPEELRGYDS-----GPEG--GAAASPPPDAELAACHP--AAWS 633
               GP  AG  +  T  P+ + G        G  G  G    P P  E     P  A+  
Sbjct: 938  GADGP--AG--APGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGE 993

Query: 634  RGPAPPLA------------FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681
            RGP  P+               GAPGA    P   G   A G        GP  A  APG
Sbjct: 994  RGPPGPMGPPGLAGPPGESGREGAPGAEGS-PGRDGSPGAKGDRGETGPAGPPGAPGAPG 1052

Query: 682  ALDPGPSPGTSGGKAAAGAGAGASSRSPKQAR 713
            A  P    G SG +   G    A    P  AR
Sbjct: 1053 APGPVGPAGKSGDRGETGPAGPAGPVGPVGAR 1084



 Score =  104 bits (260), Expect = 3e-22
 Identities = 195/757 (25%), Positives = 234/757 (30%), Gaps = 118/757 (15%)

Query: 27   PRPPGSPRPPPPVT-PAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAG-PTRTSR 84
            P P G P PP     P +    GA G  G K  A   G  G A    S   AG P     
Sbjct: 475  PGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGL 534

Query: 85   PPASGR----GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 140
            P A G     G   P  K   PGP    GR      PG  GQ G+        A G+  +
Sbjct: 535  PGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGK 594

Query: 141  APKRSALS-----AGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 195
            A +R           A +D      G P PA     R    E G P  +P  +  P   G
Sbjct: 595  AGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERG---EQG-PAGSPGFQGLPGPAG 650

Query: 196  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQR-PASRSLSSSATPLSSPARSGP----SA 250
            P        E     P       PS   G +  P  R +     P      +G      A
Sbjct: 651  PPGEAGKPGEQGV--PGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGA 708

Query: 251  RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS----------- 299
            +G   AP  P      GLQ +      P  + AA   GP      A P            
Sbjct: 709  KGDAGAPGAPGSQGAPGLQGM------PGERGAAGLPGPKGDRGDAGPKGADGSPGKDGV 762

Query: 300  -----PSAPPSPSAPPSL--QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352
                 P  PP P+  P    ++ PS PA P    T + G+P  +      P PP      
Sbjct: 763  RGLTGPIGPPGPAGAPGDKGESGPSGPAGP----TGARGAPGDRGE----PGPPGPAGFA 814

Query: 353  PPPQAP--PALALPPLQAPPSPPASPP--LSPLATPSP----QAPNALAVHLLQAPFSPP 404
             PP A   P     P  A     A PP    P   P P     AP A        P    
Sbjct: 815  GPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGAT 874

Query: 405  PSPPVQAPFSPP-----ASPPVSPSAT-------PPSQAPPSLAAPPLQV-PPSPP--AS 449
              P       PP     A PP  P          P  +  P  A  P +V PP PP  A 
Sbjct: 875  GFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGP--AGRPGEVGPPGPPGPAG 932

Query: 450  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 509
               SP A  P  AP       +   +     P          LP P      Q P   S 
Sbjct: 933  EKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASG 992

Query: 510  SL-PMSPLATPPPQAPPVLA----APLLQVPPSPPASPTLQAPRRPPTP-GPDTSVSGPR 563
               P  P+  P    PP  +    AP  +  P    SP  +  R    P GP  +   P 
Sbjct: 993  ERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPG 1052

Query: 564  LTLALAPGPPPPPSRSPSSTLSGP-----DLAGHSSSATSTPEELRGYDSGPEG------ 612
                 APGP  P  +S     +GP      +    +   + P+  RG D G  G      
Sbjct: 1053 -----APGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRG-DKGETGEQGDRG 1106

Query: 613  --------GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL 664
                    G    P P        P+  S GPA P    G+ GAP       G    +GL
Sbjct: 1107 IKGHRGFSGLQGPPGPPGSPGEQGPSGAS-GPAGPRGPPGSAGAP-------GKDGLNGL 1158

Query: 665  CTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAG 701
                   GP   T   G + P   PG  G      AG
Sbjct: 1159 PGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAG 1195



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 179/731 (24%), Positives = 214/731 (29%), Gaps = 185/731 (25%)

Query: 11   GAAARTPAARAPGLLTPRPPGSP-----RPPPPVTPAALRVLGAAGAVGRKPLAERAGGI 65
            GA   T +  +PG      P  P     RP PP  P A    G  G  G K  A   G  
Sbjct: 536  GAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKA 595

Query: 66   GGATIPESAPRAGPTRTSRP-----------PASGRGERAP---PAKNTSPGPVSSPGRA 111
            G   +P      GP                 PA  RGE+ P   P     PGP   PG A
Sbjct: 596  GERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEA 655

Query: 112  SGTTR---------PGPLGQKGLRISAEETVARGKATEAPKRSALSA----GARRDTSGP 158
                          PGP G +G R    E   +G    A  R A  A    GA+ D   P
Sbjct: 656  GKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAP 715

Query: 159  -TPGTPSPAMARRSRAAGTEVGLPRPAPS---ARPRPPTEGPRKSVSSASEHSTTEPSPA 214
              PG+      +         GLP P      A P+     P K            P PA
Sbjct: 716  GAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPA 775

Query: 215  ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS-ARGTPRAPAHPSQPKPKGLQALRP 273
                     G   PA                 GP+ ARG P     P  P P G      
Sbjct: 776  GAPGDKGESGPSGPA-----------------GPTGARGAPGDRGEPGPPGPAGFAG--- 815

Query: 274  PQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSP 333
                PP  D  P            P  +     + PP     P+ PA PP     ++G+P
Sbjct: 816  ----PPGADGQPGAK-------GEPGDAGAKGDAGPPG----PAGPAGPPGPIG-NVGAP 859

Query: 334  TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 393
              +        P     AT  P A   +  P       PP  P   P      + P    
Sbjct: 860  GAKGARGSAGPPG----ATGFPGAAGRVGPPGPSGNAGPPGPP--GPAGKEGGKGPRGET 913

Query: 394  VHLLQAPFSPPPSPPVQAPFSPPASPPVS-PSATPPSQAPPSLAA--------------- 437
                +     PP PP   P     SP    P+  P +  P  +A                
Sbjct: 914  GPAGRPGEVGPPGPP--GPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERG 971

Query: 438  -PPLQVPPSPPASPPMSPSA----TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQAL 492
             P L  P   P     S ++     P P  PP LA PP +  +    AP A  +P     
Sbjct: 972  FPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREG--APGAEGSPGRDGS 1029

Query: 493  PSP--------PASFPGQAPFSPSASLPMSPLATPP------PQAPPVLAAPL------- 531
            P          PA  PG AP +P A  P+ P           P  P     P+       
Sbjct: 1030 PGAKGDRGETGPAGPPG-APGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAG 1088

Query: 532  ---------------------------LQVPPSPPASPTLQ---------APRRPP---- 551
                                       LQ PP PP SP  Q          PR PP    
Sbjct: 1089 PQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAG 1148

Query: 552  TPGPD--------TSVSGPRLTLALA-----PGPPPPPSRSPSSTLSGPDLAGHSSSATS 598
             PG D            GPR     A     PGPP PP         GP  AG   S   
Sbjct: 1149 APGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGP------PGPPSAGFDFSFLP 1202

Query: 599  TPEELRGYDSG 609
             P + + +D G
Sbjct: 1203 QPPQEKAHDGG 1213



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 192/805 (23%), Positives = 235/805 (29%), Gaps = 165/805 (20%)

Query: 86  PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG-----LRISAEETVARGKATE 140
           P   RG   PP ++  PG    PG       PGP G  G     L    +E    G +  
Sbjct: 119 PRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVP 178

Query: 141 APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV 200
            P    +     R   GP PG P P   +  +    E G P  +    PR P   P K+ 
Sbjct: 179 GP----MGPSGPRGLPGP-PGAPGP---QGFQGPPGEPGEPGASGPMGPRGPPGPPGKNG 230

Query: 201 SSASEHSTTEPSPAARRRPSAGGGLQRPA----------------SRSLSSSATPLSSPA 244
                     P       P    GL   A                ++  +  A P   P 
Sbjct: 231 DDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPG 290

Query: 245 RSGPSA-------RGTPRAPAHPSQPKPKGLQ-------ALRPPQVTPPRKDAAPALGPL 290
             G +        RG P     P  P P G +       A  PP  T P   A P   P 
Sbjct: 291 SPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGP---AGPPGFPG 347

Query: 291 SSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPL 350
           +        P  P     P  ++  P PP   P+ A    G+P            P +  
Sbjct: 348 AVGAKGEAGPQGPRGSEGPQGVRGEPGPPG--PAGAAGPAGNPGAD-------GQPGAKG 398

Query: 351 ATPPPQAPPALALPPLQAPPSP--PASPPLSPLATPSPQAPNALAVHLLQAPFSP----- 403
           A   P    A   P  + P  P  P  PP     +  P AP +      +    P     
Sbjct: 399 ANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQG 458

Query: 404 PPSPPVQ----------APFSPPASP-------------------PVSPSATPPSQAPPS 434
           PP P  +           P   P  P                   P  P+    S  P  
Sbjct: 459 PPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAG 518

Query: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPP-----LAAPPLQLAKPPPQAPP-ALATPP 488
               P +      A  P +   T  P +P P        P  Q  +P P  PP A     
Sbjct: 519 PKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAG 578

Query: 489 LQALPSP--PASFPGQA-----PFSPSASLPMSPLATPPPQAPPVLAAPL----LQVPPS 537
           +   P P   A  PG+A     P  P A  P         Q PP  A P      Q P  
Sbjct: 579 VMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAG 638

Query: 538 PPASPTLQAPRRPP----------------TPGPDTSVSGPRLTLAL-----APGPPPPP 576
            P    L  P  PP                 PGP    SG R            GPP P 
Sbjct: 639 SPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGP----SGARGERGFPGERGVQGPPGPA 694

Query: 577 SRSPSSTLSGPDLAGHSSSATSTP--EELRGYDSGP-EGGAAASPPPDAELAACHPAAWS 633
               ++   G D A   + A   P  +   G    P E GAA  P P  +     P    
Sbjct: 695 GPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGAD 754

Query: 634 RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL-DPGP----- 687
             P      RG  G   P  PA  PG   G        GP  A  APG   +PGP     
Sbjct: 755 GSPGKD-GVRGLTGPIGPPGPAGAPGD-KGESGPSGPAGPTGARGAPGDRGEPGPPGPAG 812

Query: 688 ---------SPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLA 738
                     PG  G    AGA   A    P        P+G + A   +          
Sbjct: 813 FAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAK---------- 862

Query: 739 AAEGAAG--GSGGGPGGAEGGGVTG 761
            A G+AG  G+ G PG A   G  G
Sbjct: 863 GARGSAGPPGATGFPGAAGRVGPPG 887



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 128/505 (25%), Positives = 158/505 (31%), Gaps = 88/505 (17%)

Query: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
           S S T   +    GP     PR P  P+                PP +D  P    L   
Sbjct: 99  SESPTDQETTGVEGPKGDTGPRGPRGPA---------------GPPGRDGIPGQPGL--- 140

Query: 294 PLATPSPSAPPSPSAPPSLQTLPSPPAT----PPSQATTSLGSPTLQATHSFLPSPPLSP 349
               P P  PP P  PP L    +P  +      S    S+  P   +    LP PP +P
Sbjct: 141 ----PGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAP 196

Query: 350 LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 409
                   P     PP + P  P AS P+ P   P P   N             P  P  
Sbjct: 197 -------GPQGFQGPPGE-PGEPGASGPMGPRGPPGPPGKNG-----DDGEAGKPGRPGE 243

Query: 410 QAPFSPPASPPVSPSATPPS----QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP 465
           + P  P  +  +  +A  P     +    L        P+ P   P SP     P    P
Sbjct: 244 RGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGP 303

Query: 466 LAAPPLQLAKPPPQAP---------PALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 516
              P  +  +P    P            A PP    P+ P  FPG       A  P  P 
Sbjct: 304 RGLPG-ERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAG-PQGPR 361

Query: 517 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP 576
            +  PQ         ++  P PP       P   P         G      +A  P  P 
Sbjct: 362 GSEGPQG--------VRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPG 413

Query: 577 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 636
           +R P    SGP   G          E     S  + GA   P P              GP
Sbjct: 414 ARGP----SGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVG-------VQGPPGP 462

Query: 637 APPLAFRGAPGAP----LPWPPAT--GPGS-----ADGLCTIYETEGPESATPAPGALDP 685
           A     RGA G P    LP PP    GPGS     ADG   +   +GP     +PG   P
Sbjct: 463 AGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADG---VAGPKGPAGERGSPGPAGP 519

Query: 686 GPSPGTSGGKAAAG-AGAGASSRSP 709
             SPG +G    AG  GA   + SP
Sbjct: 520 KGSPGEAGRPGEAGLPGAKGLTGSP 544


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.127    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,582,195
Number of Sequences: 37866
Number of extensions: 4871262
Number of successful extensions: 182942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2044
Number of HSP's successfully gapped in prelim test: 3569
Number of HSP's that attempted gapping in prelim test: 24567
Number of HSP's gapped (non-prelim): 54145
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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