Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 116256352

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
         (1807 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]           3581   0.0  
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]           3522   0.0  
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]           3416   0.0  
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2...   101   8e-21
gi|118600961 akt substrate AS250 [Homo sapiens]                       101   8e-21
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1...   100   2e-20
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi...    73   2e-12
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi...    73   2e-12
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi...    73   2e-12
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ...    68   9e-11
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ...    68   9e-11
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa...    67   2e-10
gi|112421013 signal-induced proliferation-associated 1 like 2 [H...    67   2e-10
gi|206725526 signal-induced proliferation-associated protein 1 [...    65   8e-10
gi|206725523 signal-induced proliferation-associated protein 1 [...    65   8e-10
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom...    65   8e-10
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho...    63   2e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        41   0.009
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                 41   0.012
gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap...    40   0.027
gi|145199237 transcription elongation factor B polypeptide 3 bin...    39   0.035
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         39   0.060
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    38   0.078
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]            37   0.13 
gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo ...    37   0.23 
gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo ...    37   0.23 
gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo ...    37   0.23 
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    36   0.39 
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    36   0.39 
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              36   0.39 

>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
          Length = 1807

 Score = 3581 bits (9286), Expect = 0.0
 Identities = 1807/1807 (100%), Positives = 1807/1807 (100%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960

Query: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
            PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020

Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
            ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080

Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
            LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140

Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
            ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200

Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
            RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260

Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
            AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320

Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
            EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380

Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
            PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440

Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
            PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500

Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
            FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560

Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
            ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620

Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
            IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680

Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
            NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740

Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
            IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800

Query: 1801 EDFTEFV 1807
            EDFTEFV
Sbjct: 1801 EDFTEFV 1807


>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
          Length = 1784

 Score = 3522 bits (9133), Expect = 0.0
 Identities = 1784/1807 (98%), Positives = 1784/1807 (98%), Gaps = 23/1807 (1%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960

Query: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
            PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020

Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
            ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080

Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
            LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140

Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
            ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200

Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
            RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260

Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
            AKPPPLPRSNT                       DSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1261 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1297

Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
            EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1298 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1357

Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
            PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1358 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1417

Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
            PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1418 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1477

Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
            FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1478 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1537

Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
            ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1538 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1597

Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
            IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1598 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1657

Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
            NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1658 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1717

Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
            IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1718 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1777

Query: 1801 EDFTEFV 1807
            EDFTEFV
Sbjct: 1778 EDFTEFV 1784


>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
          Length = 1740

 Score = 3416 bits (8858), Expect = 0.0
 Identities = 1740/1807 (96%), Positives = 1740/1807 (96%), Gaps = 67/1807 (3%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK               
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945

Query: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
                                         RIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 946  -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976

Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
            ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 977  ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036

Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
            LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096

Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
            ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156

Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
            RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216

Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
            AKPPPLPRSNT                       DSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1217 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1253

Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
            EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1254 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1313

Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
            PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1314 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1373

Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
            PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1374 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1433

Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
            FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1434 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1493

Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
            ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1494 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1553

Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
            IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1554 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1613

Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
            NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1614 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1673

Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
            IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1674 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1733

Query: 1801 EDFTEFV 1807
            EDFTEFV
Sbjct: 1734 EDFTEFV 1740


>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
            [Homo sapiens]
          Length = 2083

 Score =  101 bits (251), Expect = 8e-21
 Identities = 71/266 (26%), Positives = 130/266 (48%), Gaps = 13/266 (4%)

Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
            L  +++   R ++ LD     +THKIAV YV EGQ +   +IL+N  GS  Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843

Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
              + L + C     ++GGL      G  T  +    ++ +FH++T MP+ D D     K 
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898

Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698
            RHLGND V IV+++   D++ G I  +F  V +++ P+      + +  + ++       
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958

Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758
               IV+ + LP + R  A++A+ A +      +   +Y + +  R R+++ + Q   E  
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012

Query: 1759 AYSNPSLPLVHPPSHSKAPAQTPAEP 1784
             + + +  +  P  +   P+   + P
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPSDAGSYP 2038


>gi|118600961 akt substrate AS250 [Homo sapiens]
          Length = 1873

 Score =  101 bits (251), Expect = 8e-21
 Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)

Query: 1513 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1572
            +  K   L  ++    R ++ LD     +THKIAV Y+ EGQ + + +ILSNE GS  Y 
Sbjct: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675

Query: 1573 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1631
            +F+ GLG  ++L   C     ++GGL   G  GQ    +    ++ +FH++T MP+ D D
Sbjct: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730

Query: 1632 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1691
                 K RHLGND V IV+++   D++ G I   F  V +I+ P+      +++  + ++
Sbjct: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790

Query: 1692 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1722
                      IVS + LP +     ++A+ A
Sbjct: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821


>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
            [Homo sapiens]
          Length = 2036

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 70/260 (26%), Positives = 128/260 (49%), Gaps = 13/260 (5%)

Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
            L  +++   R ++ LD     +THKIAV YV EGQ +   +IL+N  GS  Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843

Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
              + L + C     ++GGL      G  T  +    ++ +FH++T MP+ D D     K 
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898

Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698
            RHLGND V IV+++   D++ G I  +F  V +++ P+      + +  + ++       
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958

Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758
               IV+ + LP + R  A++A+ A +      +   +Y + +  R R+++ + Q   E  
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012

Query: 1759 AYSNPSLPLVHPPSHSKAPA 1778
             + + +  +  P  +   P+
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPS 2032


>gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens]
          Length = 663

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 171  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225

Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 226  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281

Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 282  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320


>gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens]
          Length = 727

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 235  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 289

Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 290  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 345

Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 346  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 384


>gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens]
          Length = 681

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 171  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225

Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 226  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281

Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 282  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320


>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
            [Homo sapiens]
          Length = 715

 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)

Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570
            P+L P  SQ           I SYD H      K  V+Y    Q+  E  +  N   S  
Sbjct: 223  PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 271

Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628
            + EFL  LG  I L+D    K + GGLDV  G+ G +  Y    D  + +FH++T +P  
Sbjct: 272  FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 327

Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
            D D  +  +KRH+GND V+I++ +    F    I   F   +++V
Sbjct: 328  DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 372


>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
            [Homo sapiens]
          Length = 730

 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)

Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570
            P+L P  SQ           I SYD H      K  V+Y    Q+  E  +  N   S  
Sbjct: 238  PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 286

Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628
            + EFL  LG  I L+D    K + GGLDV  G+ G +  Y    D  + +FH++T +P  
Sbjct: 287  FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 342

Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
            D D  +  +KRH+GND V+I++ +    F    I   F   +++V
Sbjct: 343  DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 387


>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
            sapiens]
          Length = 1013

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)

Query: 1528 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1587
            ++ + +L++       K  VL+  +GQ   +  + SNE GS  + +FL  LG  I LK  
Sbjct: 188  QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246

Query: 1588 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1643
                 Y GGLD      G    +T     +IM   FH++T++P    +K + ++KRH+GN
Sbjct: 247  TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300

Query: 1644 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1673
            D V+IV+ +  E    FK   I+  F  +  +V
Sbjct: 301  DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333


>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
            sapiens]
          Length = 1722

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)

Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581
            N  +  E+ ++L +Q  S+  HKI +LY   GQS  E  + +NE     + EFL  LG+ 
Sbjct: 587  NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644

Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640
            + LK     +  L    D  G    +T     ++M   FH++TL+P    ++ +  +KRH
Sbjct: 645  VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701

Query: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673
            +GND V+IV+ + G   F   +I+  F  V VIV
Sbjct: 702  IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735


>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)

Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
            L + S    R++  LD+       K+ +LY   GQ + E  + +N+     + +FLT LG
Sbjct: 310  LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368

Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
             ++ LK  +  +  L    D  G    +T     +IM   FH++T++P    ++ +  +K
Sbjct: 369  DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425

Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
            RH+GND V+IV+ + G + F   TI+  F  V ++V
Sbjct: 426  RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461


>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)

Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
            L + S    R++  LD+       K+ +LY   GQ + E  + +N+     + +FLT LG
Sbjct: 310  LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368

Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
             ++ LK  +  +  L    D  G    +T     +IM   FH++T++P    ++ +  +K
Sbjct: 369  DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425

Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
            RH+GND V+IV+ + G + F   TI+  F  V ++V
Sbjct: 426  RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461


>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
            sapiens]
          Length = 1804

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%)

Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581
            N  +  E+ ++L +Q  +Y   K+ ++Y   GQS  E  + +NE     + EFL  LG  
Sbjct: 591  NTPKVTEQLMKLDEQGLNYQ-QKVGIMYCKAGQSTEE-EMYNNESAGPAFEEFLQLLGER 648

Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640
            + LK  +  +  L    D  G    +T     +IM   FH++T++P    +K +  +KRH
Sbjct: 649  VRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIM---FHVSTMLPYTPNNKQQLLRKRH 705

Query: 1641 LGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
            +GND V+IV+ + G + F    I+  F  V VIV
Sbjct: 706  IGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIV 739


>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
            sapiens]
          Length = 1781

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 12/136 (8%)

Query: 1543 HKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV--- 1599
            HK+ +LY   GQS+ E  + +NE     + EFL+ +G  + LK       Y   LDV   
Sbjct: 623  HKVGILYCKAGQSSEE-EMYNNEEAGPAFEEFLSLIGEKVCLKGFTK---YAAQLDVKTD 678

Query: 1600 -CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGE-DF 1657
              G    +T     +IM   FH++TL+P    ++ +  +KRH+GND V+I++ + G   F
Sbjct: 679  STGTHSLYTMYQDYEIM---FHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPF 735

Query: 1658 KLGTIKGQFNFVHVIV 1673
                I+  F  V +IV
Sbjct: 736  TPKNIRSHFQHVFIIV 751


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 41.2 bits (95), Expect = 0.009
 Identities = 76/299 (25%), Positives = 121/299 (40%), Gaps = 36/299 (12%)

Query: 1216 LSPFSSDINNMPLQELSNALMAAER------FKEHRDTALYKSLSVPA-ASTAKPPPLPR 1268
            LS  SS++  M      ++    ER        + +  A  +++ VP+ AS+   P    
Sbjct: 1253 LSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSP 1312

Query: 1269 SNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDR 1328
             +   S S L ++S    L    S       M  G   EV   +  P L  +E    +D 
Sbjct: 1313 EHKELSNSPLRENSFGSPLEFRNS-GPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDM 1371

Query: 1329 RTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVD-LSFQPSQPLSKSSS 1387
            +  + +RSS  SS E   L  + +   G+   + +SS    P +D +   PS+  S S+S
Sbjct: 1372 KEQS-TRSSGHSSSE---LSPDAVEKAGMSSNQSISS----PVLDAVPRTPSRERSSSAS 1423

Query: 1388 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASG------EDSRGQP 1441
            SPE++      G P   +   R       R  SGT    S + S+ G        SRG+ 
Sbjct: 1424 SPEMKD-----GLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRS 1478

Query: 1442 E---GPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINP 1497
            E    P P + P++P   RPR  + S S+P    K +     +S + +S  +K     P
Sbjct: 1479 ECDSSPEPKALPQTP---RPR--SRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532



 Score = 39.7 bits (91), Expect = 0.027
 Identities = 50/171 (29%), Positives = 64/171 (37%), Gaps = 26/171 (15%)

Query: 1335 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1394
            RS S SS + K+     L  R        S  G  P VD   + S   S+S SSPE++  
Sbjct: 1556 RSESDSSPDSKAKTRTPLRQR--------SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDK 1607

Query: 1395 QDIL--------GDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP 1446
                          P  KA   R  P       S    G S   S+S E S   PE P  
Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS---PEHPPK 1664

Query: 1447 SSSPRSPSGLRPRGYTISDSAPSRRGKRVE-------RDALKSRATASNAE 1490
            S + R  S   P   T S + P RR  R         R + +SR+ +S+ E
Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 123/542 (22%), Positives = 193/542 (35%), Gaps = 72/542 (13%)

Query: 981  SVSEHVVRSRIQTSLTSASLGSA-DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFT 1039
            SV E+  +SRI  +LT+ SLG+A    S++ A  + +   +      + +      +  +
Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS 2230

Query: 1040 AVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSP- 1098
             +P  S      LA  RT        L    T       +L         + P ++ +P 
Sbjct: 2231 RIPAAS-AAAMNLASARTPAIPTAVNLADSRTPAAAAAMNL---------ASPRTAVAPS 2280

Query: 1099 GVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGP 1158
             V++   +   A   + AG +    A     S++G  G    A + P+S    S T   P
Sbjct: 2281 AVNLADPRTPTAPAVNLAGARTP--AALAALSLTGS-GTPPTAANYPSS----SRTPQAP 2333

Query: 1159 RTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRR--PTGNTSWLMSLENPL 1216
             +A    P  A A   V +      AA  P      A +   R  P  + + L S   PL
Sbjct: 2334 ASANLVGPRSAHATAPVNIAGSRTAAALAP------ASLTSARMAPALSGANLTSPRVPL 2387

Query: 1217 SPFS--SDINNMPLQELSN-----ALMAAERFKEHRDTALYKSLSVPAASTAKPP--PLP 1267
            S +   S   + PL + +      +  +  R    R  +    +    + +  PP    P
Sbjct: 2388 SAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQP 2447

Query: 1268 RSNTVASFSSLYQSSC----QGQLHRSVSWADSAVVMEEGSPGE------VPV------- 1310
            RS   ++FS   QS C       +  S S +  AV     S G+      VP        
Sbjct: 2448 RSPVPSAFSD--QSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505

Query: 1311 LVEPPGLEDVE-----AAL--GMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV 1363
            + EPP     +     AAL    +RR+ + S SSS SS    S  +          +   
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565

Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD--KADVGRLSPEVKARSQSG 1421
            SS   +P V L   PS   +   +  E        G P +   A   R S    + S S 
Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVRE--------GRPPEPTPAKRKRRSSSSSSSSSSS 2617

Query: 1422 TLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALK 1481
            +    S++ S+S   S         SSS  SPS  +P    +   A  ++    ER +  
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS 2677

Query: 1482 SR 1483
             R
Sbjct: 2678 PR 2679


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score = 40.8 bits (94), Expect = 0.012
 Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 8/127 (6%)

Query: 1366 EGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPE-VKARSQSGTLD 1424
            +G R  + L      P  +  S   +Q +  + G+ G+K D G   P+ +     S   D
Sbjct: 1488 DGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRD 1547

Query: 1425 GESAAWSASGED-SRGQPEGPLPSSSPRSP------SGLRPRGYTISDSAPSRRGKRVER 1477
            G        G+D S G P  P P   P +P        + P+G       P  +G+R ER
Sbjct: 1548 GSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607

Query: 1478 DALKSRA 1484
              L+S+A
Sbjct: 1608 GDLQSQA 1614


>gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens]
          Length = 1268

 Score = 39.7 bits (91), Expect = 0.027
 Identities = 61/244 (25%), Positives = 88/244 (36%), Gaps = 19/244 (7%)

Query: 996  TSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGG 1055
            +S  L S  +N +     SL   +   T T  D ++  V  N    PK SPV   +L+G 
Sbjct: 263  SSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCPVMQNVQP-PKSSPVVSTVLSGS 321

Query: 1056 R----TKTWLVGNKLVTVTTSVGTGTRSLL--GLDSGELQSGPESSSSPGVHVRQTKEAP 1109
                 T+T    N  V   TSV   +  L   G+  GE  +   SS+   +      E  
Sbjct: 322  SGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEE 381

Query: 1110 AKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL-DVPASQFLGSATSPGPRTAPAAKPEK 1168
             + + +AG   S          +    L  G+  D+ +S     A  P P   PA+ P  
Sbjct: 382  EEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAP 441

Query: 1169 ASAGTRVPVQEKTNLAAY---VPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINN 1225
            ASA   V  Q       +    P L  G+           T+ L+S   P +P  S    
Sbjct: 442  ASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNA--------TAPLISGVQPSNPVYSGFQQ 493

Query: 1226 MPLQ 1229
             P Q
Sbjct: 494  YPQQ 497


>gi|145199237 transcription elongation factor B polypeptide 3 binding
            protein 1 [Homo sapiens]
          Length = 1221

 Score = 39.3 bits (90), Expect = 0.035
 Identities = 55/221 (24%), Positives = 75/221 (33%), Gaps = 21/221 (9%)

Query: 1307 EVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSE 1366
            E+    +PP  E +EA  G  R T   +    V   +              P +   S +
Sbjct: 314  EIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPAS------PAQVQSSQD 367

Query: 1367 GG-----RPSVDLSFQPSQPLSKSSSSPELQTLQDILGDP-----GDKADVGRLSPEVKA 1416
            GG     +P    +  P  P  K  +  + +T     G P      DK      SP  KA
Sbjct: 368  GGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKA 427

Query: 1417 RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRP---RGYTISDSAPSRRGK 1473
                GT    S+A   +    +G+P+ P    SP S    RP   RG       P R+  
Sbjct: 428  ERPEGTKKKPSSATPVA-TSGKGRPDRPARRPSPTSGDS-RPAAGRGPPRPLQLPDRKST 485

Query: 1474 RVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDES 1514
            +     L  R   S  E      P      L H+  FGDES
Sbjct: 486  KAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES 526


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 38.5 bits (88), Expect = 0.060
 Identities = 85/333 (25%), Positives = 128/333 (38%), Gaps = 43/333 (12%)

Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPL---QELSNALMAAERFKEHRDTALYKSLSVPA 1257
            RP GN       E     FS  I+N PL   QE  N   + +  +    TA    +SV +
Sbjct: 2046 RPAGNKD-----EEEYEGFSI-ISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSS 2099

Query: 1258 ASTAKPPPLPRSNT-VASFSSLYQ------SSCQGQLHRSVSWADSAVV-MEEGSPGEVP 1309
              +   P  P   T + S +S +Q      SS  G+  +S +  DS V   EE +P   P
Sbjct: 2100 KGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDP 2159

Query: 1310 VLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIER------VV 1363
              +    LE+ ++ L    R        S S+  E  + A          E       V+
Sbjct: 2160 QELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVL 2219

Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQ------TLQDILGDPGDKADVGRLSPEVKAR 1417
            S +  +PS  ++ +P  P ++SSS P++       T  ++          GR SP     
Sbjct: 2220 SHQKSQPS-PVTVKPKPP-ARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCD-- 2275

Query: 1418 SQSGTLDGE-------SAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSR 1470
            SQ+  LD         S+ +SA    S   P    PSS  +SP+G  P       SA S 
Sbjct: 2276 SQTSQLDQPLFKLKYPSSPYSAHISKS---PRNMSPSSGHQSPAGSAPSPALSYSSAGSA 2332

Query: 1471 RGKRVERDALKSRATASNAEKVPGINPSFVFLQ 1503
            R    +   +     A+  EKV  ++   +F Q
Sbjct: 2333 RSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQ 2365


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 38.1 bits (87), Expect = 0.078
 Identities = 102/433 (23%), Positives = 149/433 (34%), Gaps = 69/433 (15%)

Query: 1085 SGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG---- 1140
            S ++ S    SSSP V            +SQA +++     +R  +      L +     
Sbjct: 469  SSQMSSDSSRSSSPSVDT--------STDSQASEEIQVLPEERSDTPEVHPPLPISQSPE 520

Query: 1141 --ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEIL 1198
              + D  + ++  S  S G RT      +K S     P Q++T+ +   PLLT       
Sbjct: 521  NESNDRRSRRYSVSERSFGSRTT-----KKLSTLQSAP-QQQTSSSPPPPLLTPPPPLQP 574

Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERF-----KEHRDTALYKS- 1252
                + +T WLM    PL+      +  P+Q    +++    F     K  R    Y S 
Sbjct: 575  ASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSS 634

Query: 1253 --------LSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVV--MEE 1302
                    +  P     +PPPL   +    F+S + +S      R  S   S     M +
Sbjct: 635  AKYAKEGLIRKPIFDNFRPPPLTPEDV--GFASGFSASGTAASARLFSPLHSGTRFDMHK 692

Query: 1303 GSPGEVPVLVEPPGLEDVEAALGM-------DRRTDAYSRSSSVSSQEEKSLHAEELVGR 1355
             SP     L+  P     EA   +         RT A + SS VS+++ K      +   
Sbjct: 693  RSP-----LLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSE 747

Query: 1356 GIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVK 1415
                   + +  GR S      P  P S  SSS  +                  L+P   
Sbjct: 748  PRSPSHSMRTRSGRLSSS-ELSPLTPPSSVSSSLSISV---------SPLATSALNPTFT 797

Query: 1416 ARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPR------SPSGLRPRGYTISDSAPS 1469
              S S T  GESA  +         P  P  SSSP       +P     RG    D AP 
Sbjct: 798  FPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN-KDKAPE 856

Query: 1470 RRGKRVERDALKS 1482
               K  +RDA KS
Sbjct: 857  ELSK--DRDADKS 867


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score = 37.4 bits (85), Expect = 0.13
 Identities = 52/246 (21%), Positives = 88/246 (35%), Gaps = 46/246 (18%)

Query: 1090 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQF 1149
            S P SSS+P        ++        G +   G R R++  S      V    +P    
Sbjct: 236  SSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETS------VAPFALPTVSL 289

Query: 1150 LGSATS--PGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVP---------LLTQGWAEIL 1198
            L + T   P P  A + +    + G R P+    +   ++P          L      IL
Sbjct: 290  LPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 349

Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE---HRDTALYKSLSV 1255
            +  P+G+ + L+++          +  +P    + +LM  ER      H   +  +S  +
Sbjct: 350  LLDPSGSHAPLLTVPG--------LGPLPFH-FAQSLMTTERLSGSGLHWPLSRTRSEPL 400

Query: 1256 PAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPP 1315
            P ++TA PPP P    +    +  Q                 V+     P E P L + P
Sbjct: 401  PPSATAPPPPGPMQPRLEQLKTHVQ-----------------VIKRSAKPSEKPRLRQIP 443

Query: 1316 GLEDVE 1321
              ED+E
Sbjct: 444  SAEDLE 449


>gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo
           sapiens]
          Length = 242

 Score = 36.6 bits (83), Expect = 0.23
 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)

Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
           +  C + EP+RG ++K    L P TGP P  +P+GP V   GS    LL  VLLQ L
Sbjct: 99  FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152


>gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo
           sapiens]
          Length = 242

 Score = 36.6 bits (83), Expect = 0.23
 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)

Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
           +  C + EP+RG ++K    L P TGP P  +P+GP V   GS    LL  VLLQ L
Sbjct: 99  FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152


>gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo
           sapiens]
          Length = 242

 Score = 36.6 bits (83), Expect = 0.23
 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)

Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
           +  C + EP+RG ++K    L P TGP P  +P+GP V   GS    LL  VLLQ L
Sbjct: 99  FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
            sapiens]
          Length = 824

 Score = 35.8 bits (81), Expect = 0.39
 Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%)

Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298
            R  A   S   PA S  +PP  P       S+ V + +SLYQSS    L R +S A  A 
Sbjct: 443  RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 502

Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340
               +    E P +  P GL D  A+     R D    S++++
Sbjct: 503  DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 543


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 731

 Score = 35.8 bits (81), Expect = 0.39
 Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%)

Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298
            R  A   S   PA S  +PP  P       S+ V + +SLYQSS    L R +S A  A 
Sbjct: 350  RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 409

Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340
               +    E P +  P GL D  A+     R D    S++++
Sbjct: 410  DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 450


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 35.8 bits (81), Expect = 0.39
 Identities = 66/255 (25%), Positives = 93/255 (36%), Gaps = 23/255 (9%)

Query: 1263 PPPLPRSNTVASFSSLYQSSCQGQLHR------SVSWADSAVVMEEGSPGEVPVLVEPPG 1316
            P  L  + T+   + +YQ S +G+         S+   D AV  +  SP    V+     
Sbjct: 198  PIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAV--DSASPVYQAVIKSQNK 255

Query: 1317 LEDVEAALGMDRRTDAYSRSSSVSSQEE-----KSLHAEELVGRGIPIER--VVSSEGGR 1369
             ED EA     R ++  SRS  + +Q       +    E L     PIE   V +S+   
Sbjct: 256  PED-EADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATT 314

Query: 1370 PSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAA 1429
            P +  S QP    S S++SP L T                 SP    R Q+ +     AA
Sbjct: 315  PLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAA 374

Query: 1430 WSASGEDSRGQPEGP-LPSSSPR--SPSGLRPRGY---TISDSAPSRRGKRVERDALKSR 1483
             SA    +    EGP  P+  PR  + + +RP  Y     S  +PS            S 
Sbjct: 375  SSAPATHT-SYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSP 433

Query: 1484 ATASNAEKVPGINPS 1498
            A A      P   PS
Sbjct: 434  APAYTPSPAPAYTPS 448


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,971,866
Number of Sequences: 37866
Number of extensions: 3485415
Number of successful extensions: 17473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 16871
Number of HSP's gapped (non-prelim): 894
length of query: 1807
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1690
effective length of database: 13,817,196
effective search space: 23351061240
effective search space used: 23351061240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press