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Search of human proteins with 116256352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
(1807 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 3581 0.0
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 3522 0.0
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 3416 0.0
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 101 8e-21
gi|118600961 akt substrate AS250 [Homo sapiens] 101 8e-21
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 100 2e-20
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 73 2e-12
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 73 2e-12
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 73 2e-12
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 67 2e-10
gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 67 2e-10
gi|206725526 signal-induced proliferation-associated protein 1 [... 65 8e-10
gi|206725523 signal-induced proliferation-associated protein 1 [... 65 8e-10
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 65 8e-10
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 63 2e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 41 0.009
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 41 0.012
gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap... 40 0.027
gi|145199237 transcription elongation factor B polypeptide 3 bin... 39 0.035
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 39 0.060
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 38 0.078
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 37 0.13
gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo ... 37 0.23
gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo ... 37 0.23
gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo ... 37 0.23
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 36 0.39
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 36 0.39
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 36 0.39
>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
Length = 1807
Score = 3581 bits (9286), Expect = 0.0
Identities = 1807/1807 (100%), Positives = 1807/1807 (100%)
Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
Query: 1801 EDFTEFV 1807
EDFTEFV
Sbjct: 1801 EDFTEFV 1807
>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
Length = 1784
Score = 3522 bits (9133), Expect = 0.0
Identities = 1784/1807 (98%), Positives = 1784/1807 (98%), Gaps = 23/1807 (1%)
Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
AKPPPLPRSNT DSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1261 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1297
Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1298 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1357
Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1358 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1417
Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1418 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1477
Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1478 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1537
Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1538 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1597
Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1598 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1657
Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1658 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1717
Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1718 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1777
Query: 1801 EDFTEFV 1807
EDFTEFV
Sbjct: 1778 EDFTEFV 1784
>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
Length = 1740
Score = 3416 bits (8858), Expect = 0.0
Identities = 1740/1807 (96%), Positives = 1740/1807 (96%), Gaps = 67/1807 (3%)
Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960
RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK
Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945
Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020
RIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 946 -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976
Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 977 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036
Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140
LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096
Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200
ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156
Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260
RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216
Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320
AKPPPLPRSNT DSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1217 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1253
Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380
EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1254 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1313
Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440
PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1314 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1373
Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500
PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1374 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1433
Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560
FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1434 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1493
Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620
ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1494 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1553
Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680
IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1554 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1613
Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740
NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1614 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1673
Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800
IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1674 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1733
Query: 1801 EDFTEFV 1807
EDFTEFV
Sbjct: 1734 EDFTEFV 1740
>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
[Homo sapiens]
Length = 2083
Score = 101 bits (251), Expect = 8e-21
Identities = 71/266 (26%), Positives = 130/266 (48%), Gaps = 13/266 (4%)
Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843
Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
+ L + C ++GGL G T + ++ +FH++T MP+ D D K
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898
Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698
RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958
Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758
IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012
Query: 1759 AYSNPSLPLVHPPSHSKAPAQTPAEP 1784
+ + + + P + P+ + P
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPSDAGSYP 2038
>gi|118600961 akt substrate AS250 [Homo sapiens]
Length = 1873
Score = 101 bits (251), Expect = 8e-21
Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)
Query: 1513 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1572
+ K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y
Sbjct: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675
Query: 1573 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1631
+F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D
Sbjct: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730
Query: 1632 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1691
K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++
Sbjct: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790
Query: 1692 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1722
IVS + LP + ++A+ A
Sbjct: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821
>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
[Homo sapiens]
Length = 2036
Score = 99.8 bits (247), Expect = 2e-20
Identities = 70/260 (26%), Positives = 128/260 (49%), Gaps = 13/260 (5%)
Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843
Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
+ L + C ++GGL G T + ++ +FH++T MP+ D D K
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898
Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698
RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958
Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758
IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012
Query: 1759 AYSNPSLPLVHPPSHSKAPA 1778
+ + + + P + P+
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPS 2032
>gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens]
Length = 663
Score = 73.2 bits (178), Expect = 2e-12
Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)
Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL
Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225
Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D +
Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281
Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
+KRH+GND V++V+ D F I F +V+V
Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens]
Length = 727
Score = 73.2 bits (178), Expect = 2e-12
Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)
Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL
Sbjct: 235 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 289
Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D +
Sbjct: 290 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 345
Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
+KRH+GND V++V+ D F I F +V+V
Sbjct: 346 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 384
>gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens]
Length = 681
Score = 73.2 bits (178), Expect = 2e-12
Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)
Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576
P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL
Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225
Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634
LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D +
Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281
Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
+KRH+GND V++V+ D F I F +V+V
Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320
>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
[Homo sapiens]
Length = 715
Score = 67.8 bits (164), Expect = 9e-11
Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570
P+L P SQ I SYD H K V+Y Q+ E + N S
Sbjct: 223 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 271
Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628
+ EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P
Sbjct: 272 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 327
Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
D D + +KRH+GND V+I++ + F I F +++V
Sbjct: 328 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 372
>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
[Homo sapiens]
Length = 730
Score = 67.8 bits (164), Expect = 9e-11
Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570
P+L P SQ I SYD H K V+Y Q+ E + N S
Sbjct: 238 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 286
Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628
+ EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P
Sbjct: 287 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 342
Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673
D D + +KRH+GND V+I++ + F I F +++V
Sbjct: 343 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 387
>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
Length = 1013
Score = 66.6 bits (161), Expect = 2e-10
Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)
Query: 1528 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1587
++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK
Sbjct: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246
Query: 1588 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1643
Y GGLD G +T +IM FH++T++P +K + ++KRH+GN
Sbjct: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300
Query: 1644 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1673
D V+IV+ + E FK I+ F + +V
Sbjct: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333
>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
sapiens]
Length = 1722
Score = 66.6 bits (161), Expect = 2e-10
Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)
Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581
N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+
Sbjct: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640
+ LK + L D G +T ++M FH++TL+P ++ + +KRH
Sbjct: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
Query: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673
+GND V+IV+ + G F +I+ F V VIV
Sbjct: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 64.7 bits (156), Expect = 8e-10
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)
Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG
Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368
Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
++ LK + + L D G +T +IM FH++T++P ++ + +K
Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425
Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
RH+GND V+IV+ + G + F TI+ F V ++V
Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461
>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 64.7 bits (156), Expect = 8e-10
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)
Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG
Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368
Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
++ LK + + L D G +T +IM FH++T++P ++ + +K
Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425
Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
RH+GND V+IV+ + G + F TI+ F V ++V
Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461
>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
sapiens]
Length = 1804
Score = 64.7 bits (156), Expect = 8e-10
Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%)
Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581
N + E+ ++L +Q +Y K+ ++Y GQS E + +NE + EFL LG
Sbjct: 591 NTPKVTEQLMKLDEQGLNYQ-QKVGIMYCKAGQSTEE-EMYNNESAGPAFEEFLQLLGER 648
Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640
+ LK + + L D G +T +IM FH++T++P +K + +KRH
Sbjct: 649 VRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIM---FHVSTMLPYTPNNKQQLLRKRH 705
Query: 1641 LGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
+GND V+IV+ + G + F I+ F V VIV
Sbjct: 706 IGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIV 739
>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
sapiens]
Length = 1781
Score = 63.2 bits (152), Expect = 2e-09
Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 12/136 (8%)
Query: 1543 HKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV--- 1599
HK+ +LY GQS+ E + +NE + EFL+ +G + LK Y LDV
Sbjct: 623 HKVGILYCKAGQSSEE-EMYNNEEAGPAFEEFLSLIGEKVCLKGFTK---YAAQLDVKTD 678
Query: 1600 -CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGE-DF 1657
G +T +IM FH++TL+P ++ + +KRH+GND V+I++ + G F
Sbjct: 679 STGTHSLYTMYQDYEIM---FHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPF 735
Query: 1658 KLGTIKGQFNFVHVIV 1673
I+ F V +IV
Sbjct: 736 TPKNIRSHFQHVFIIV 751
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 41.2 bits (95), Expect = 0.009
Identities = 76/299 (25%), Positives = 121/299 (40%), Gaps = 36/299 (12%)
Query: 1216 LSPFSSDINNMPLQELSNALMAAER------FKEHRDTALYKSLSVPA-ASTAKPPPLPR 1268
LS SS++ M ++ ER + + A +++ VP+ AS+ P
Sbjct: 1253 LSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSP 1312
Query: 1269 SNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDR 1328
+ S S L ++S L S M G EV + P L +E +D
Sbjct: 1313 EHKELSNSPLRENSFGSPLEFRNS-GPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDM 1371
Query: 1329 RTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVD-LSFQPSQPLSKSSS 1387
+ + +RSS SS E L + + G+ + +SS P +D + PS+ S S+S
Sbjct: 1372 KEQS-TRSSGHSSSE---LSPDAVEKAGMSSNQSISS----PVLDAVPRTPSRERSSSAS 1423
Query: 1388 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASG------EDSRGQP 1441
SPE++ G P + R R SGT S + S+ G SRG+
Sbjct: 1424 SPEMKD-----GLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRS 1478
Query: 1442 E---GPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINP 1497
E P P + P++P RPR + S S+P K + +S + +S +K P
Sbjct: 1479 ECDSSPEPKALPQTP---RPR--SRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532
Score = 39.7 bits (91), Expect = 0.027
Identities = 50/171 (29%), Positives = 64/171 (37%), Gaps = 26/171 (15%)
Query: 1335 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1394
RS S SS + K+ L R S G P VD + S S+S SSPE++
Sbjct: 1556 RSESDSSPDSKAKTRTPLRQR--------SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDK 1607
Query: 1395 QDIL--------GDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP 1446
P KA R P S G S S+S E S PE P
Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS---PEHPPK 1664
Query: 1447 SSSPRSPSGLRPRGYTISDSAPSRRGKRVE-------RDALKSRATASNAE 1490
S + R S P T S + P RR R R + +SR+ +S+ E
Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715
Score = 37.7 bits (86), Expect = 0.10
Identities = 123/542 (22%), Positives = 193/542 (35%), Gaps = 72/542 (13%)
Query: 981 SVSEHVVRSRIQTSLTSASLGSA-DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFT 1039
SV E+ +SRI +LT+ SLG+A S++ A + + + + + + +
Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS 2230
Query: 1040 AVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSP- 1098
+P S LA RT L T +L + P ++ +P
Sbjct: 2231 RIPAAS-AAAMNLASARTPAIPTAVNLADSRTPAAAAAMNL---------ASPRTAVAPS 2280
Query: 1099 GVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGP 1158
V++ + A + AG + A S++G G A + P+S S T P
Sbjct: 2281 AVNLADPRTPTAPAVNLAGARTP--AALAALSLTGS-GTPPTAANYPSS----SRTPQAP 2333
Query: 1159 RTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRR--PTGNTSWLMSLENPL 1216
+A P A A V + AA P A + R P + + L S PL
Sbjct: 2334 ASANLVGPRSAHATAPVNIAGSRTAAALAP------ASLTSARMAPALSGANLTSPRVPL 2387
Query: 1217 SPFS--SDINNMPLQELSN-----ALMAAERFKEHRDTALYKSLSVPAASTAKPP--PLP 1267
S + S + PL + + + + R R + + + + PP P
Sbjct: 2388 SAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQP 2447
Query: 1268 RSNTVASFSSLYQSSC----QGQLHRSVSWADSAVVMEEGSPGE------VPV------- 1310
RS ++FS QS C + S S + AV S G+ VP
Sbjct: 2448 RSPVPSAFSD--QSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505
Query: 1311 LVEPPGLEDVE-----AAL--GMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV 1363
+ EPP + AAL +RR+ + S SSS SS S + +
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565
Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD--KADVGRLSPEVKARSQSG 1421
SS +P V L PS + + E G P + A R S + S S
Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVRE--------GRPPEPTPAKRKRRSSSSSSSSSSS 2617
Query: 1422 TLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALK 1481
+ S++ S+S S SSS SPS +P + A ++ ER +
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS 2677
Query: 1482 SR 1483
R
Sbjct: 2678 PR 2679
>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
Length = 1796
Score = 40.8 bits (94), Expect = 0.012
Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 8/127 (6%)
Query: 1366 EGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPE-VKARSQSGTLD 1424
+G R + L P + S +Q + + G+ G+K D G P+ + S D
Sbjct: 1488 DGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRD 1547
Query: 1425 GESAAWSASGED-SRGQPEGPLPSSSPRSP------SGLRPRGYTISDSAPSRRGKRVER 1477
G G+D S G P P P P +P + P+G P +G+R ER
Sbjct: 1548 GSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607
Query: 1478 DALKSRA 1484
L+S+A
Sbjct: 1608 GDLQSQA 1614
>gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens]
Length = 1268
Score = 39.7 bits (91), Expect = 0.027
Identities = 61/244 (25%), Positives = 88/244 (36%), Gaps = 19/244 (7%)
Query: 996 TSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGG 1055
+S L S +N + SL + T T D ++ V N PK SPV +L+G
Sbjct: 263 SSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCPVMQNVQP-PKSSPVVSTVLSGS 321
Query: 1056 R----TKTWLVGNKLVTVTTSVGTGTRSLL--GLDSGELQSGPESSSSPGVHVRQTKEAP 1109
T+T N V TSV + L G+ GE + SS+ + E
Sbjct: 322 SGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEE 381
Query: 1110 AKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL-DVPASQFLGSATSPGPRTAPAAKPEK 1168
+ + +AG S + L G+ D+ +S A P P PA+ P
Sbjct: 382 EEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAP 441
Query: 1169 ASAGTRVPVQEKTNLAAY---VPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINN 1225
ASA V Q + P L G+ T+ L+S P +P S
Sbjct: 442 ASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNA--------TAPLISGVQPSNPVYSGFQQ 493
Query: 1226 MPLQ 1229
P Q
Sbjct: 494 YPQQ 497
>gi|145199237 transcription elongation factor B polypeptide 3 binding
protein 1 [Homo sapiens]
Length = 1221
Score = 39.3 bits (90), Expect = 0.035
Identities = 55/221 (24%), Positives = 75/221 (33%), Gaps = 21/221 (9%)
Query: 1307 EVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSE 1366
E+ +PP E +EA G R T + V + P + S +
Sbjct: 314 EIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPAS------PAQVQSSQD 367
Query: 1367 GG-----RPSVDLSFQPSQPLSKSSSSPELQTLQDILGDP-----GDKADVGRLSPEVKA 1416
GG +P + P P K + + +T G P DK SP KA
Sbjct: 368 GGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKA 427
Query: 1417 RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRP---RGYTISDSAPSRRGK 1473
GT S+A + +G+P+ P SP S RP RG P R+
Sbjct: 428 ERPEGTKKKPSSATPVA-TSGKGRPDRPARRPSPTSGDS-RPAAGRGPPRPLQLPDRKST 485
Query: 1474 RVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDES 1514
+ L R S E P L H+ FGDES
Sbjct: 486 KAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES 526
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 38.5 bits (88), Expect = 0.060
Identities = 85/333 (25%), Positives = 128/333 (38%), Gaps = 43/333 (12%)
Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPL---QELSNALMAAERFKEHRDTALYKSLSVPA 1257
RP GN E FS I+N PL QE N + + + TA +SV +
Sbjct: 2046 RPAGNKD-----EEEYEGFSI-ISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSS 2099
Query: 1258 ASTAKPPPLPRSNT-VASFSSLYQ------SSCQGQLHRSVSWADSAVV-MEEGSPGEVP 1309
+ P P T + S +S +Q SS G+ +S + DS V EE +P P
Sbjct: 2100 KGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDP 2159
Query: 1310 VLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIER------VV 1363
+ LE+ ++ L R S S+ E + A E V+
Sbjct: 2160 QELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVL 2219
Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQ------TLQDILGDPGDKADVGRLSPEVKAR 1417
S + +PS ++ +P P ++SSS P++ T ++ GR SP
Sbjct: 2220 SHQKSQPS-PVTVKPKPP-ARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCD-- 2275
Query: 1418 SQSGTLDGE-------SAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSR 1470
SQ+ LD S+ +SA S P PSS +SP+G P SA S
Sbjct: 2276 SQTSQLDQPLFKLKYPSSPYSAHISKS---PRNMSPSSGHQSPAGSAPSPALSYSSAGSA 2332
Query: 1471 RGKRVERDALKSRATASNAEKVPGINPSFVFLQ 1503
R + + A+ EKV ++ +F Q
Sbjct: 2333 RSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQ 2365
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 38.1 bits (87), Expect = 0.078
Identities = 102/433 (23%), Positives = 149/433 (34%), Gaps = 69/433 (15%)
Query: 1085 SGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG---- 1140
S ++ S SSSP V +SQA +++ +R + L +
Sbjct: 469 SSQMSSDSSRSSSPSVDT--------STDSQASEEIQVLPEERSDTPEVHPPLPISQSPE 520
Query: 1141 --ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEIL 1198
+ D + ++ S S G RT +K S P Q++T+ + PLLT
Sbjct: 521 NESNDRRSRRYSVSERSFGSRTT-----KKLSTLQSAP-QQQTSSSPPPPLLTPPPPLQP 574
Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERF-----KEHRDTALYKS- 1252
+ +T WLM PL+ + P+Q +++ F K R Y S
Sbjct: 575 ASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSS 634
Query: 1253 --------LSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVV--MEE 1302
+ P +PPPL + F+S + +S R S S M +
Sbjct: 635 AKYAKEGLIRKPIFDNFRPPPLTPEDV--GFASGFSASGTAASARLFSPLHSGTRFDMHK 692
Query: 1303 GSPGEVPVLVEPPGLEDVEAALGM-------DRRTDAYSRSSSVSSQEEKSLHAEELVGR 1355
SP L+ P EA + RT A + SS VS+++ K +
Sbjct: 693 RSP-----LLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSE 747
Query: 1356 GIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVK 1415
+ + GR S P P S SSS + L+P
Sbjct: 748 PRSPSHSMRTRSGRLSSS-ELSPLTPPSSVSSSLSISV---------SPLATSALNPTFT 797
Query: 1416 ARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPR------SPSGLRPRGYTISDSAPS 1469
S S T GESA + P P SSSP +P RG D AP
Sbjct: 798 FPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN-KDKAPE 856
Query: 1470 RRGKRVERDALKS 1482
K +RDA KS
Sbjct: 857 ELSK--DRDADKS 867
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 37.4 bits (85), Expect = 0.13
Identities = 52/246 (21%), Positives = 88/246 (35%), Gaps = 46/246 (18%)
Query: 1090 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQF 1149
S P SSS+P ++ G + G R R++ S V +P
Sbjct: 236 SSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETS------VAPFALPTVSL 289
Query: 1150 LGSATS--PGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVP---------LLTQGWAEIL 1198
L + T P P A + + + G R P+ + ++P L IL
Sbjct: 290 LPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 349
Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE---HRDTALYKSLSV 1255
+ P+G+ + L+++ + +P + +LM ER H + +S +
Sbjct: 350 LLDPSGSHAPLLTVPG--------LGPLPFH-FAQSLMTTERLSGSGLHWPLSRTRSEPL 400
Query: 1256 PAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPP 1315
P ++TA PPP P + + Q V+ P E P L + P
Sbjct: 401 PPSATAPPPPGPMQPRLEQLKTHVQ-----------------VIKRSAKPSEKPRLRQIP 443
Query: 1316 GLEDVE 1321
ED+E
Sbjct: 444 SAEDLE 449
>gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo
sapiens]
Length = 242
Score = 36.6 bits (83), Expect = 0.23
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)
Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
+ C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L
Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152
>gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo
sapiens]
Length = 242
Score = 36.6 bits (83), Expect = 0.23
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)
Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
+ C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L
Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152
>gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo
sapiens]
Length = 242
Score = 36.6 bits (83), Expect = 0.23
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)
Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697
+ C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L
Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 35.8 bits (81), Expect = 0.39
Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%)
Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298
R A S PA S +PP P S+ V + +SLYQSS L R +S A A
Sbjct: 443 RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 502
Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340
+ E P + P GL D A+ R D S++++
Sbjct: 503 DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 543
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 35.8 bits (81), Expect = 0.39
Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%)
Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298
R A S PA S +PP P S+ V + +SLYQSS L R +S A A
Sbjct: 350 RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 409
Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340
+ E P + P GL D A+ R D S++++
Sbjct: 410 DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 450
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 35.8 bits (81), Expect = 0.39
Identities = 66/255 (25%), Positives = 93/255 (36%), Gaps = 23/255 (9%)
Query: 1263 PPPLPRSNTVASFSSLYQSSCQGQLHR------SVSWADSAVVMEEGSPGEVPVLVEPPG 1316
P L + T+ + +YQ S +G+ S+ D AV + SP V+
Sbjct: 198 PIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAV--DSASPVYQAVIKSQNK 255
Query: 1317 LEDVEAALGMDRRTDAYSRSSSVSSQEE-----KSLHAEELVGRGIPIER--VVSSEGGR 1369
ED EA R ++ SRS + +Q + E L PIE V +S+
Sbjct: 256 PED-EADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATT 314
Query: 1370 PSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAA 1429
P + S QP S S++SP L T SP R Q+ + AA
Sbjct: 315 PLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAA 374
Query: 1430 WSASGEDSRGQPEGP-LPSSSPR--SPSGLRPRGY---TISDSAPSRRGKRVERDALKSR 1483
SA + EGP P+ PR + + +RP Y S +PS S
Sbjct: 375 SSAPATHT-SYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSP 433
Query: 1484 ATASNAEKVPGINPS 1498
A A P PS
Sbjct: 434 APAYTPSPAPAYTPS 448
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,971,866
Number of Sequences: 37866
Number of extensions: 3485415
Number of successful extensions: 17473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 16871
Number of HSP's gapped (non-prelim): 894
length of query: 1807
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1690
effective length of database: 13,817,196
effective search space: 23351061240
effective search space used: 23351061240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.