BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] (1807 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 3581 0.0 gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 3522 0.0 gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 3416 0.0 gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 101 8e-21 gi|118600961 akt substrate AS250 [Homo sapiens] 101 8e-21 gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 100 2e-20 gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 73 2e-12 gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 73 2e-12 gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 73 2e-12 gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11 gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11 gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 67 2e-10 gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 67 2e-10 gi|206725526 signal-induced proliferation-associated protein 1 [... 65 8e-10 gi|206725523 signal-induced proliferation-associated protein 1 [... 65 8e-10 gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 65 8e-10 gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 63 2e-09 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 41 0.009 gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 41 0.012 gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap... 40 0.027 gi|145199237 transcription elongation factor B polypeptide 3 bin... 39 0.035 gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 39 0.060 gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 38 0.078 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 37 0.13 gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo ... 37 0.23 gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo ... 37 0.23 gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo ... 37 0.23 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 36 0.39 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 36 0.39 gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 36 0.39 >gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] Length = 1807 Score = 3581 bits (9286), Expect = 0.0 Identities = 1807/1807 (100%), Positives = 1807/1807 (100%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV Sbjct: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320 Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ Sbjct: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380 Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ Sbjct: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440 Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV Sbjct: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500 Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA Sbjct: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560 Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH Sbjct: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620 Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC Sbjct: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680 Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW Sbjct: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740 Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV Sbjct: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800 Query: 1801 EDFTEFV 1807 EDFTEFV Sbjct: 1801 EDFTEFV 1807 >gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] Length = 1784 Score = 3522 bits (9133), Expect = 0.0 Identities = 1784/1807 (98%), Positives = 1784/1807 (98%), Gaps = 23/1807 (1%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320 AKPPPLPRSNT DSAVVMEEGSPGEVPVLVEPPGLEDV Sbjct: 1261 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1297 Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ Sbjct: 1298 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1357 Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ Sbjct: 1358 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1417 Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV Sbjct: 1418 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1477 Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA Sbjct: 1478 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1537 Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH Sbjct: 1538 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1597 Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC Sbjct: 1598 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1657 Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW Sbjct: 1658 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1717 Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV Sbjct: 1718 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1777 Query: 1801 EDFTEFV 1807 EDFTEFV Sbjct: 1778 EDFTEFV 1784 >gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] Length = 1740 Score = 3416 bits (8858), Expect = 0.0 Identities = 1740/1807 (96%), Positives = 1740/1807 (96%), Gaps = 67/1807 (3%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 RIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 946 -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 977 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216 Query: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320 AKPPPLPRSNT DSAVVMEEGSPGEVPVLVEPPGLEDV Sbjct: 1217 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1253 Query: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ Sbjct: 1254 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1313 Query: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ Sbjct: 1314 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1373 Query: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV Sbjct: 1374 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1433 Query: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA Sbjct: 1434 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1493 Query: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH Sbjct: 1494 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1553 Query: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC Sbjct: 1554 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1613 Query: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW Sbjct: 1614 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1673 Query: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV Sbjct: 1674 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1733 Query: 1801 EDFTEFV 1807 EDFTEFV Sbjct: 1734 EDFTEFV 1740 >gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2 [Homo sapiens] Length = 2083 Score = 101 bits (251), Expect = 8e-21 Identities = 71/266 (26%), Positives = 130/266 (48%), Gaps = 13/266 (4%) Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579 L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843 Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638 + L + C ++GGL G T + ++ +FH++T MP+ D D K Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898 Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698 RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++ Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958 Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758 IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012 Query: 1759 AYSNPSLPLVHPPSHSKAPAQTPAEP 1784 + + + + P + P+ + P Sbjct: 2013 TFEDFAAQVFSPAPYHHLPSDAGSYP 2038 >gi|118600961 akt substrate AS250 [Homo sapiens] Length = 1873 Score = 101 bits (251), Expect = 8e-21 Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%) Query: 1513 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1572 + K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y Sbjct: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675 Query: 1573 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1631 +F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D Sbjct: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730 Query: 1632 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1691 K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++ Sbjct: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790 Query: 1692 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1722 IVS + LP + ++A+ A Sbjct: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821 >gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1 [Homo sapiens] Length = 2036 Score = 99.8 bits (247), Expect = 2e-20 Identities = 70/260 (26%), Positives = 128/260 (49%), Gaps = 13/260 (5%) Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579 L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843 Query: 1580 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638 + L + C ++GGL G T + ++ +FH++T MP+ D D K Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898 Query: 1639 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1698 RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++ Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958 Query: 1699 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1758 IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012 Query: 1759 AYSNPSLPLVHPPSHSKAPA 1778 + + + + P + P+ Sbjct: 2013 TFEDFAAQVFSPAPYHHLPS 2032 >gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens] Length = 663 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225 Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281 Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673 +KRH+GND V++V+ D F I F +V+V Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320 >gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens] Length = 727 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 235 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 289 Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 290 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 345 Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673 +KRH+GND V++V+ D F I F +V+V Sbjct: 346 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 384 >gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens] Length = 681 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1576 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225 Query: 1577 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1634 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281 Query: 1635 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673 +KRH+GND V++V+ D F I F +V+V Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320 >gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2 [Homo sapiens] Length = 715 Score = 67.8 bits (164), Expect = 9e-11 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%) Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570 P+L P SQ I SYD H K V+Y Q+ E + N S Sbjct: 223 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 271 Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628 + EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P Sbjct: 272 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 327 Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673 D D + +KRH+GND V+I++ + F I F +++V Sbjct: 328 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 372 >gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1 [Homo sapiens] Length = 730 Score = 67.8 bits (164), Expect = 9e-11 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%) Query: 1517 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1570 P+L P SQ I SYD H K V+Y Q+ E + N S Sbjct: 238 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 286 Query: 1571 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1628 + EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P Sbjct: 287 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 342 Query: 1629 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1673 D D + +KRH+GND V+I++ + F I F +++V Sbjct: 343 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 387 >gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sapiens] Length = 1013 Score = 66.6 bits (161), Expect = 2e-10 Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%) Query: 1528 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1587 ++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK Sbjct: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246 Query: 1588 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1643 Y GGLD G +T +IM FH++T++P +K + ++KRH+GN Sbjct: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300 Query: 1644 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1673 D V+IV+ + E FK I+ F + +V Sbjct: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333 >gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo sapiens] Length = 1722 Score = 66.6 bits (161), Expect = 2e-10 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581 N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+ Sbjct: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644 Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640 + LK + L D G +T ++M FH++TL+P ++ + +KRH Sbjct: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701 Query: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673 +GND V+IV+ + G F +I+ F V VIV Sbjct: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735 >gi|206725526 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 64.7 bits (156), Expect = 8e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 >gi|206725523 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 64.7 bits (156), Expect = 8e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 Query: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 Query: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 >gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo sapiens] Length = 1804 Score = 64.7 bits (156), Expect = 8e-10 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Query: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581 N + E+ ++L +Q +Y K+ ++Y GQS E + +NE + EFL LG Sbjct: 591 NTPKVTEQLMKLDEQGLNYQ-QKVGIMYCKAGQSTEE-EMYNNESAGPAFEEFLQLLGER 648 Query: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640 + LK + + L D G +T +IM FH++T++P +K + +KRH Sbjct: 649 VRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIM---FHVSTMLPYTPNNKQQLLRKRH 705 Query: 1641 LGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673 +GND V+IV+ + G + F I+ F V VIV Sbjct: 706 IGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIV 739 >gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo sapiens] Length = 1781 Score = 63.2 bits (152), Expect = 2e-09 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 12/136 (8%) Query: 1543 HKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV--- 1599 HK+ +LY GQS+ E + +NE + EFL+ +G + LK Y LDV Sbjct: 623 HKVGILYCKAGQSSEE-EMYNNEEAGPAFEEFLSLIGEKVCLKGFTK---YAAQLDVKTD 678 Query: 1600 -CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGE-DF 1657 G +T +IM FH++TL+P ++ + +KRH+GND V+I++ + G F Sbjct: 679 STGTHSLYTMYQDYEIM---FHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPF 735 Query: 1658 KLGTIKGQFNFVHVIV 1673 I+ F V +IV Sbjct: 736 TPKNIRSHFQHVFIIV 751 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 41.2 bits (95), Expect = 0.009 Identities = 76/299 (25%), Positives = 121/299 (40%), Gaps = 36/299 (12%) Query: 1216 LSPFSSDINNMPLQELSNALMAAER------FKEHRDTALYKSLSVPA-ASTAKPPPLPR 1268 LS SS++ M ++ ER + + A +++ VP+ AS+ P Sbjct: 1253 LSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSP 1312 Query: 1269 SNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDR 1328 + S S L ++S L S M G EV + P L +E +D Sbjct: 1313 EHKELSNSPLRENSFGSPLEFRNS-GPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDM 1371 Query: 1329 RTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVD-LSFQPSQPLSKSSS 1387 + + +RSS SS E L + + G+ + +SS P +D + PS+ S S+S Sbjct: 1372 KEQS-TRSSGHSSSE---LSPDAVEKAGMSSNQSISS----PVLDAVPRTPSRERSSSAS 1423 Query: 1388 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASG------EDSRGQP 1441 SPE++ G P + R R SGT S + S+ G SRG+ Sbjct: 1424 SPEMKD-----GLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRS 1478 Query: 1442 E---GPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINP 1497 E P P + P++P RPR + S S+P K + +S + +S +K P Sbjct: 1479 ECDSSPEPKALPQTP---RPR--SRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532 Score = 39.7 bits (91), Expect = 0.027 Identities = 50/171 (29%), Positives = 64/171 (37%), Gaps = 26/171 (15%) Query: 1335 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1394 RS S SS + K+ L R S G P VD + S S+S SSPE++ Sbjct: 1556 RSESDSSPDSKAKTRTPLRQR--------SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDK 1607 Query: 1395 QDIL--------GDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP 1446 P KA R P S G S S+S E S PE P Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS---PEHPPK 1664 Query: 1447 SSSPRSPSGLRPRGYTISDSAPSRRGKRVE-------RDALKSRATASNAE 1490 S + R S P T S + P RR R R + +SR+ +S+ E Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715 Score = 37.7 bits (86), Expect = 0.10 Identities = 123/542 (22%), Positives = 193/542 (35%), Gaps = 72/542 (13%) Query: 981 SVSEHVVRSRIQTSLTSASLGSA-DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFT 1039 SV E+ +SRI +LT+ SLG+A S++ A + + + + + + + Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS 2230 Query: 1040 AVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSP- 1098 +P S LA RT L T +L + P ++ +P Sbjct: 2231 RIPAAS-AAAMNLASARTPAIPTAVNLADSRTPAAAAAMNL---------ASPRTAVAPS 2280 Query: 1099 GVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGP 1158 V++ + A + AG + A S++G G A + P+S S T P Sbjct: 2281 AVNLADPRTPTAPAVNLAGARTP--AALAALSLTGS-GTPPTAANYPSS----SRTPQAP 2333 Query: 1159 RTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRR--PTGNTSWLMSLENPL 1216 +A P A A V + AA P A + R P + + L S PL Sbjct: 2334 ASANLVGPRSAHATAPVNIAGSRTAAALAP------ASLTSARMAPALSGANLTSPRVPL 2387 Query: 1217 SPFS--SDINNMPLQELSN-----ALMAAERFKEHRDTALYKSLSVPAASTAKPP--PLP 1267 S + S + PL + + + + R R + + + + PP P Sbjct: 2388 SAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQP 2447 Query: 1268 RSNTVASFSSLYQSSC----QGQLHRSVSWADSAVVMEEGSPGE------VPV------- 1310 RS ++FS QS C + S S + AV S G+ VP Sbjct: 2448 RSPVPSAFSD--QSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505 Query: 1311 LVEPPGLEDVE-----AAL--GMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV 1363 + EPP + AAL +RR+ + S SSS SS S + + Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565 Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD--KADVGRLSPEVKARSQSG 1421 SS +P V L PS + + E G P + A R S + S S Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVRE--------GRPPEPTPAKRKRRSSSSSSSSSSS 2617 Query: 1422 TLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALK 1481 + S++ S+S S SSS SPS +P + A ++ ER + Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS 2677 Query: 1482 SR 1483 R Sbjct: 2678 PR 2679 >gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] Length = 1796 Score = 40.8 bits (94), Expect = 0.012 Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 8/127 (6%) Query: 1366 EGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPE-VKARSQSGTLD 1424 +G R + L P + S +Q + + G+ G+K D G P+ + S D Sbjct: 1488 DGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRD 1547 Query: 1425 GESAAWSASGED-SRGQPEGPLPSSSPRSP------SGLRPRGYTISDSAPSRRGKRVER 1477 G G+D S G P P P P +P + P+G P +G+R ER Sbjct: 1548 GSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607 Query: 1478 DALKSRA 1484 L+S+A Sbjct: 1608 GDLQSQA 1614 >gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens] Length = 1268 Score = 39.7 bits (91), Expect = 0.027 Identities = 61/244 (25%), Positives = 88/244 (36%), Gaps = 19/244 (7%) Query: 996 TSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGG 1055 +S L S +N + SL + T T D ++ V N PK SPV +L+G Sbjct: 263 SSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCPVMQNVQP-PKSSPVVSTVLSGS 321 Query: 1056 R----TKTWLVGNKLVTVTTSVGTGTRSLL--GLDSGELQSGPESSSSPGVHVRQTKEAP 1109 T+T N V TSV + L G+ GE + SS+ + E Sbjct: 322 SGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEE 381 Query: 1110 AKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL-DVPASQFLGSATSPGPRTAPAAKPEK 1168 + + +AG S + L G+ D+ +S A P P PA+ P Sbjct: 382 EEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAP 441 Query: 1169 ASAGTRVPVQEKTNLAAY---VPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINN 1225 ASA V Q + P L G+ T+ L+S P +P S Sbjct: 442 ASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNA--------TAPLISGVQPSNPVYSGFQQ 493 Query: 1226 MPLQ 1229 P Q Sbjct: 494 YPQQ 497 >gi|145199237 transcription elongation factor B polypeptide 3 binding protein 1 [Homo sapiens] Length = 1221 Score = 39.3 bits (90), Expect = 0.035 Identities = 55/221 (24%), Positives = 75/221 (33%), Gaps = 21/221 (9%) Query: 1307 EVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSE 1366 E+ +PP E +EA G R T + V + P + S + Sbjct: 314 EIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPAS------PAQVQSSQD 367 Query: 1367 GG-----RPSVDLSFQPSQPLSKSSSSPELQTLQDILGDP-----GDKADVGRLSPEVKA 1416 GG +P + P P K + + +T G P DK SP KA Sbjct: 368 GGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKA 427 Query: 1417 RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRP---RGYTISDSAPSRRGK 1473 GT S+A + +G+P+ P SP S RP RG P R+ Sbjct: 428 ERPEGTKKKPSSATPVA-TSGKGRPDRPARRPSPTSGDS-RPAAGRGPPRPLQLPDRKST 485 Query: 1474 RVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDES 1514 + L R S E P L H+ FGDES Sbjct: 486 KAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES 526 >gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] Length = 2481 Score = 38.5 bits (88), Expect = 0.060 Identities = 85/333 (25%), Positives = 128/333 (38%), Gaps = 43/333 (12%) Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPL---QELSNALMAAERFKEHRDTALYKSLSVPA 1257 RP GN E FS I+N PL QE N + + + TA +SV + Sbjct: 2046 RPAGNKD-----EEEYEGFSI-ISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSS 2099 Query: 1258 ASTAKPPPLPRSNT-VASFSSLYQ------SSCQGQLHRSVSWADSAVV-MEEGSPGEVP 1309 + P P T + S +S +Q SS G+ +S + DS V EE +P P Sbjct: 2100 KGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDP 2159 Query: 1310 VLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIER------VV 1363 + LE+ ++ L R S S+ E + A E V+ Sbjct: 2160 QELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVL 2219 Query: 1364 SSEGGRPSVDLSFQPSQPLSKSSSSPELQ------TLQDILGDPGDKADVGRLSPEVKAR 1417 S + +PS ++ +P P ++SSS P++ T ++ GR SP Sbjct: 2220 SHQKSQPS-PVTVKPKPP-ARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCD-- 2275 Query: 1418 SQSGTLDGE-------SAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSR 1470 SQ+ LD S+ +SA S P PSS +SP+G P SA S Sbjct: 2276 SQTSQLDQPLFKLKYPSSPYSAHISKS---PRNMSPSSGHQSPAGSAPSPALSYSSAGSA 2332 Query: 1471 RGKRVERDALKSRATASNAEKVPGINPSFVFLQ 1503 R + + A+ EKV ++ +F Q Sbjct: 2333 RSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQ 2365 >gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo sapiens] Length = 3969 Score = 38.1 bits (87), Expect = 0.078 Identities = 102/433 (23%), Positives = 149/433 (34%), Gaps = 69/433 (15%) Query: 1085 SGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG---- 1140 S ++ S SSSP V +SQA +++ +R + L + Sbjct: 469 SSQMSSDSSRSSSPSVDT--------STDSQASEEIQVLPEERSDTPEVHPPLPISQSPE 520 Query: 1141 --ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEIL 1198 + D + ++ S S G RT +K S P Q++T+ + PLLT Sbjct: 521 NESNDRRSRRYSVSERSFGSRTT-----KKLSTLQSAP-QQQTSSSPPPPLLTPPPPLQP 574 Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERF-----KEHRDTALYKS- 1252 + +T WLM PL+ + P+Q +++ F K R Y S Sbjct: 575 ASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSS 634 Query: 1253 --------LSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVV--MEE 1302 + P +PPPL + F+S + +S R S S M + Sbjct: 635 AKYAKEGLIRKPIFDNFRPPPLTPEDV--GFASGFSASGTAASARLFSPLHSGTRFDMHK 692 Query: 1303 GSPGEVPVLVEPPGLEDVEAALGM-------DRRTDAYSRSSSVSSQEEKSLHAEELVGR 1355 SP L+ P EA + RT A + SS VS+++ K + Sbjct: 693 RSP-----LLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSE 747 Query: 1356 GIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVK 1415 + + GR S P P S SSS + L+P Sbjct: 748 PRSPSHSMRTRSGRLSSS-ELSPLTPPSSVSSSLSISV---------SPLATSALNPTFT 797 Query: 1416 ARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPR------SPSGLRPRGYTISDSAPS 1469 S S T GESA + P P SSSP +P RG D AP Sbjct: 798 FPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN-KDKAPE 856 Query: 1470 RRGKRVERDALKS 1482 K +RDA KS Sbjct: 857 ELSK--DRDADKS 867 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 37.4 bits (85), Expect = 0.13 Identities = 52/246 (21%), Positives = 88/246 (35%), Gaps = 46/246 (18%) Query: 1090 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQF 1149 S P SSS+P ++ G + G R R++ S V +P Sbjct: 236 SSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETS------VAPFALPTVSL 289 Query: 1150 LGSATS--PGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVP---------LLTQGWAEIL 1198 L + T P P A + + + G R P+ + ++P L IL Sbjct: 290 LPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 349 Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE---HRDTALYKSLSV 1255 + P+G+ + L+++ + +P + +LM ER H + +S + Sbjct: 350 LLDPSGSHAPLLTVPG--------LGPLPFH-FAQSLMTTERLSGSGLHWPLSRTRSEPL 400 Query: 1256 PAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPP 1315 P ++TA PPP P + + Q V+ P E P L + P Sbjct: 401 PPSATAPPPPGPMQPRLEQLKTHVQ-----------------VIKRSAKPSEKPRLRQIP 443 Query: 1316 GLEDVE 1321 ED+E Sbjct: 444 SAEDLE 449 >gi|239757718 PREDICTED: hypothetical protein XP_002345530 [Homo sapiens] Length = 242 Score = 36.6 bits (83), Expect = 0.23 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%) Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697 + C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152 >gi|239752205 PREDICTED: hypothetical protein XP_002348148 [Homo sapiens] Length = 242 Score = 36.6 bits (83), Expect = 0.23 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%) Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697 + C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152 >gi|239746728 PREDICTED: hypothetical protein XP_002343821 [Homo sapiens] Length = 242 Score = 36.6 bits (83), Expect = 0.23 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%) Query: 643 YCVCDYMEPERGSEKKTSGPLSPPTGP-PGPAPAGPAVR-LGSVPYSLLFRVLLQCL 697 + C + EP+RG ++K L P TGP P +P+GP V GS LL VLLQ L Sbjct: 99 FLTCTFSEPQRGKDQKW---LRPRTGPSPETSPSGPIVSPTGSHLAYLLIVVLLQLL 152 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 35.8 bits (81), Expect = 0.39 Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%) Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298 R A S PA S +PP P S+ V + +SLYQSS L R +S A A Sbjct: 443 RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 502 Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340 + E P + P GL D A+ R D S++++ Sbjct: 503 DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 543 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 35.8 bits (81), Expect = 0.39 Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 7/102 (6%) Query: 1245 RDTALYKSLSVPAASTAKPPPLP------RSNTVASFSSLYQSSCQGQLHRSVSWADSAV 1298 R A S PA S +PP P S+ V + +SLYQSS L R +S A A Sbjct: 350 RSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMAS 409 Query: 1299 VMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVS 1340 + E P + P GL D A+ R D S++++ Sbjct: 410 DFRKRRKSE-PAVGPPRGLGDQSASRTSPGRVDLPGSSTTLT 450 >gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] Length = 727 Score = 35.8 bits (81), Expect = 0.39 Identities = 66/255 (25%), Positives = 93/255 (36%), Gaps = 23/255 (9%) Query: 1263 PPPLPRSNTVASFSSLYQSSCQGQLHR------SVSWADSAVVMEEGSPGEVPVLVEPPG 1316 P L + T+ + +YQ S +G+ S+ D AV + SP V+ Sbjct: 198 PIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAV--DSASPVYQAVIKSQNK 255 Query: 1317 LEDVEAALGMDRRTDAYSRSSSVSSQEE-----KSLHAEELVGRGIPIER--VVSSEGGR 1369 ED EA R ++ SRS + +Q + E L PIE V +S+ Sbjct: 256 PED-EADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATT 314 Query: 1370 PSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAA 1429 P + S QP S S++SP L T SP R Q+ + AA Sbjct: 315 PLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAA 374 Query: 1430 WSASGEDSRGQPEGP-LPSSSPR--SPSGLRPRGY---TISDSAPSRRGKRVERDALKSR 1483 SA + EGP P+ PR + + +RP Y S +PS S Sbjct: 375 SSAPATHT-SYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSP 433 Query: 1484 ATASNAEKVPGINPS 1498 A A P PS Sbjct: 434 APAYTPSPAPAYTPS 448 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 71,971,866 Number of Sequences: 37866 Number of extensions: 3485415 Number of successful extensions: 17473 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 25 Number of HSP's successfully gapped in prelim test: 167 Number of HSP's that attempted gapping in prelim test: 16871 Number of HSP's gapped (non-prelim): 894 length of query: 1807 length of database: 18,247,518 effective HSP length: 117 effective length of query: 1690 effective length of database: 13,817,196 effective search space: 23351061240 effective search space used: 23351061240 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.