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Search of human proteins with 116235485
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116235485 delta-notch-like EGF repeat-containing
transmembrane [Homo sapiens]
(737 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 1578 0.0
gi|24041035 notch 2 preproprotein [Homo sapiens] 305 1e-82
gi|148833508 notch1 preproprotein [Homo sapiens] 272 7e-73
gi|134244285 Notch homolog 3 [Homo sapiens] 269 6e-72
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 259 5e-69
gi|112420992 crumbs homolog 2 [Homo sapiens] 250 3e-66
gi|55770876 notch4 preproprotein [Homo sapiens] 248 1e-65
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 247 2e-65
gi|4557679 jagged 1 precursor [Homo sapiens] 241 2e-63
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 229 9e-60
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 225 1e-58
gi|110735443 delta-like 1 [Homo sapiens] 224 2e-58
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 224 3e-58
gi|148886654 polydom [Homo sapiens] 224 3e-58
gi|122937283 6720455I24Rik homolog [Homo sapiens] 218 1e-56
gi|188528675 slit homolog 1 [Homo sapiens] 184 3e-46
gi|11321571 slit homolog 3 [Homo sapiens] 181 2e-45
gi|224451131 eyes shut homolog isoform 2 [Homo sapiens] 181 2e-45
gi|38093661 eyes shut homolog isoform 3 [Homo sapiens] 181 2e-45
gi|4759146 slit homolog 2 [Homo sapiens] 166 9e-41
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 155 1e-37
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 155 1e-37
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 149 7e-36
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 144 4e-34
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 144 4e-34
gi|74136023 delta-like 1 homolog [Homo sapiens] 143 7e-34
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 142 9e-34
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 141 2e-33
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 140 6e-33
gi|126091152 cubilin [Homo sapiens] 135 2e-31
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 1578 bits (4085), Expect = 0.0
Identities = 737/737 (100%), Positives = 737/737 (100%)
Query: 1 MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCT 60
MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCT
Sbjct: 1 MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCT 60
Query: 61 SRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYL 120
SRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYL
Sbjct: 61 SRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYL 120
Query: 121 CICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP 180
CICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP
Sbjct: 121 CICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP 180
Query: 181 KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLW 240
KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLW
Sbjct: 181 KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLW 240
Query: 241 KVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTL 300
KVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTL
Sbjct: 241 KVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTL 300
Query: 301 VVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQN 360
VVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQN
Sbjct: 301 VVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQN 360
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE
Sbjct: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG
Sbjct: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
Query: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540
TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC
Sbjct: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540
Query: 541 ELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP 600
ELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP
Sbjct: 541 ELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP 600
Query: 601 NGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVG 660
NGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVG
Sbjct: 601 NGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVG 660
Query: 661 ICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYED 720
ICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYED
Sbjct: 661 ICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYED 720
Query: 721 YSPDDKPLVTLIKTKDL 737
YSPDDKPLVTLIKTKDL
Sbjct: 721 YSPDDKPLVTLIKTKDL 737
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 305 bits (780), Expect = 1e-82
Identities = 193/614 (31%), Positives = 273/614 (44%), Gaps = 101/614 (16%)
Query: 48 CAAQPCRNGGVCTS----------------RPEPD------PQHPAPAGE----PG-YSC 80
C + PC NG CT+ + E D P H G PG Y C
Sbjct: 148 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQC 207
Query: 81 TCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEG----------P 130
CP G +G C + PCA +PC +G + + + C C G+EG P
Sbjct: 208 QCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT--FECNCLPGFEGSTCERNIDDCP 265
Query: 131 N--CEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQK--V 186
N C+ + P Q T++ D+ L + A T + G V
Sbjct: 266 NHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV 325
Query: 187 VEMKW---DQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVT 243
W D E I D A + + S+ R+ SF + + A L+
Sbjct: 326 CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSC-------MCPEGKAGLL------ 372
Query: 244 ATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFI-----GFVNDSVTKSIVALRL 298
C L D P G L + N +I G+ T+
Sbjct: 373 ------CHLDDACISNPCH-KGALCDTNPL----NGQYICTCPQGYKGADCTED------ 415
Query: 299 TLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKP 357
V C + AN C GKC ++ F C C + Y G CE + + C P
Sbjct: 416 -----VDEC----AMANSNPCEHAGKCVN--TDGAFHCECLKGYAGPRCEMDINECHSDP 464
Query: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
CQN+A+C+D FTC+C+PG+ G C+ +I+ C +PC N C+ ++ F C
Sbjct: 465 CQNDATCLDKI-----GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCL 519
Query: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC 477
CP G+ G C+ +D C+S+PC N C + C C+ GFTG C + ID C PC
Sbjct: 520 CPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPC 579
Query: 478 AHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKG 537
HG C+ SY C+C+PGY G C ++ +EC S+PCLN C DLVNGY+C C G
Sbjct: 580 HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 639
Query: 538 THCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSC 596
+CE+ D CA+ C++G DG+N +C+C+PGFTG+ C+IDI+EC SNPC G +C
Sbjct: 640 VNCEINFDDCASNPCIHGIC--MDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATC 697
Query: 597 LDQPNGYNCHCPHG 610
++ NG+ C CP G
Sbjct: 698 INGVNGFRCICPEG 711
Score = 259 bits (662), Expect = 6e-69
Identities = 123/304 (40%), Positives = 164/304 (53%), Gaps = 13/304 (4%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C + + CTC++ + G C+ D C PC N +C D D S +T
Sbjct: 766 CQNGGTCDNLVNG--YRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFD-----DISGYT 818
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISS--LSGFTCQCPEGYFGSACEEKVDPCA 435
C C+ YTG+ CQ+ + C +PC N A C S +TC C G+ G C +D C
Sbjct: 819 CHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECI 878
Query: 436 SSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCD 494
S PC N+G C+ + C C PGF+G C + ID C +PC +G +C ++ CLC
Sbjct: 879 SKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCL 938
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLN 554
PG+ G C+ + NECLS PC N TC D VN Y C C A + G HCE + C SC N
Sbjct: 939 PGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFN 998
Query: 555 GATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVG 613
G TC DG+N +C+C GFTG C +INEC S+PC + G+C+D Y C CP G+ G
Sbjct: 999 GGTC-VDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTG 1057
Query: 614 ANCE 617
NC+
Sbjct: 1058 KNCQ 1061
Score = 256 bits (654), Expect = 5e-68
Identities = 122/322 (37%), Positives = 168/322 (52%), Gaps = 17/322 (5%)
Query: 305 STCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRKP--CQNN 361
STC + C G C + T++C C Q+ G FC E+ D C +P CQN
Sbjct: 255 STCERNIDDCPNHRCQNGGVCVDGVN--TYNCRCPPQWTGQFCTEDVDECLLQPNACQNG 312
Query: 362 ASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEG 421
+C + N + CVC+ G++G+ C ID C C G+TCI ++ F+C CPEG
Sbjct: 313 GTCANRN-----GGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEG 367
Query: 422 YFGSACEEKVDPCASSPCQNNGTCYVDGVH--FTCNCSPGFTGPTCAQLIDFCALS---P 476
G C D C S+PC C + ++ + C C G+ G C + +D CA++ P
Sbjct: 368 KAGLLCHLD-DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNP 426
Query: 477 CAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEY 535
C H G C + ++ C C GY G CE + NEC S PC N ATC D + G+ C+C+ +
Sbjct: 427 CEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGF 486
Query: 536 KGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595
KG HCEL + C + C+N C C+C PGFTG C IDI++C S PC +G
Sbjct: 487 KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAK 546
Query: 596 CLDQPNGYNCHCPHGWVGANCE 617
C+D PNGY C C G+ G CE
Sbjct: 547 CIDHPNGYECQCATGFTGVLCE 568
Score = 249 bits (635), Expect = 8e-66
Identities = 135/397 (34%), Positives = 179/397 (45%), Gaps = 87/397 (21%)
Query: 307 CVPG------ESHANDLE---CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRK 356
C+PG E N+ + C G+C K + F C C + G C+ + D C
Sbjct: 482 CMPGFKGVHCELEINECQSNPCVNNGQCVDKVNR--FQCLCPPGFTGPVCQIDIDDCSST 539
Query: 357 PCQNNASCIDA-------------------------------NEKQDG-SNFTCVCLPGY 384
PC N A CID + QDG ++TC+C PGY
Sbjct: 540 PCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGY 599
Query: 385 TGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGT 444
G +C +ID C PC N CI ++G+ C C G G CE D CAS+PC + G
Sbjct: 600 MGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIH-GI 658
Query: 445 CYVDGVH-FTCNCSPGFTG--------------------------------------PTC 465
C +DG++ ++C CSPGFTG P+C
Sbjct: 659 C-MDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSC 717
Query: 466 AQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVN 525
++ C +PC HG C + YKCLCD G+ G+ CE + NECLS PC N TC +LVN
Sbjct: 718 YSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVN 777
Query: 526 GYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINEC 585
GY C C +KG +C++ D CA+ CLN TC D TC C +TG+ C + C
Sbjct: 778 GYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPC 837
Query: 586 DSNPCHHGGSCLDQPN--GYNCHCPHGWVGANCEIHL 620
NPC + C + PN Y C C GW G C I +
Sbjct: 838 SPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI 874
Score = 246 bits (629), Expect = 4e-65
Identities = 118/305 (38%), Positives = 166/305 (54%), Gaps = 13/305 (4%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA-CQRKPCQNNASCIDANEKQDGSNFT 377
C +G C S ++C C Y G C+ A C PC+N A C E + ++T
Sbjct: 804 CLNQGTCFDDISG--YTCHCVLPYTGKNCQTVLAPCSPNPCENAAVC---KESPNFESYT 858
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
C+C PG+ G+ C ID CI PC N C ++ + C+CP G+ G CEE +D C ++
Sbjct: 859 CLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLAN 918
Query: 438 PCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDP 495
PCQN G+C +DGV+ F+C C PGFTG C ++ C PC +G TC SY C C
Sbjct: 919 PCQNGGSC-MDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQA 977
Query: 496 GYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNG 555
G+ G++CE NEC + C N TC D +N + C+C + G+ C + C++ CLN
Sbjct: 978 GFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNE 1037
Query: 556 ATCDSDGLNGT--CICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVG 613
TC DGL GT C C G+TG+ C +N C +PC + G+C+ + C CP GW G
Sbjct: 1038 GTC-VDGL-GTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAG 1095
Query: 614 ANCEI 618
A C++
Sbjct: 1096 AYCDV 1100
Score = 241 bits (616), Expect = 1e-63
Identities = 128/405 (31%), Positives = 184/405 (45%), Gaps = 105/405 (25%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C ++ ++ C C + G CEE D C PCQN SC+D + F+
Sbjct: 882 CMNHGLCHN--TQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGV-----NTFS 934
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATC------------------------------ 407
C+CLPG+TG+ CQ+ ++ C+ +PC+NG TC
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTES 994
Query: 408 --------ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSP 458
+ ++ F+C CP G+ GS C +++ C+S PC N GTC VDG+ + C+C
Sbjct: 995 SCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTC-VDGLGTYRCSCPL 1053
Query: 459 GFTGPTCAQLIDFCALSPCAH--------------------------------------- 479
G+TG C L++ C+ SPC +
Sbjct: 1054 GYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG 1113
Query: 480 ----------GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529
G C + G ++ C C GY G YCEE+ +EC S PC + ATC D + GY C
Sbjct: 1114 VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRC 1173
Query: 530 VCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNP 589
C+ Y+G +CE D C N C NG TC + C C PG G C+ +I++C P
Sbjct: 1174 ECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGP 1233
Query: 590 -CHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTN 633
C +GG C+D+ GY+C C G+ G CE G + E L+N
Sbjct: 1234 HCLNGGQCMDRIGGYSCRCLPGFAGERCE-------GDINECLSN 1271
Score = 236 bits (602), Expect = 6e-62
Identities = 120/305 (39%), Positives = 160/305 (52%), Gaps = 14/305 (4%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C G C S T+ CTC+ + G C+ DAC PC N ++C + F+C
Sbjct: 115 CLNGGTCHML-SRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTV-----ANQFSC 168
Query: 379 VCLPGYTGELCQSKIDYC-ILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
CL G+TG+ C++ ++ C I C++G TC++ + CQCP+G+ G C+ PCA S
Sbjct: 169 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPS 228
Query: 438 PCQNNGTCYVDG-VHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDP 495
PC N GTC G F CNC PGF G TC + ID C C + G C +Y C C P
Sbjct: 229 PCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPP 288
Query: 496 GYHGLYCEEEYNECLSAP--CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCL 553
+ G +C E+ +ECL P C N TC + GY CVC+ + G C D CA SC
Sbjct: 289 QWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCT 348
Query: 554 NGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP-NG-YNCHCPHGW 611
G+TC + +C+C G G C +D + C SNPCH G C P NG Y C CP G+
Sbjct: 349 PGSTCIDRVASFSCMCPEGKAGLLCHLD-DACISNPCHKGALCDTNPLNGQYICTCPQGY 407
Query: 612 VGANC 616
GA+C
Sbjct: 408 KGADC 412
Score = 232 bits (592), Expect = 8e-61
Identities = 127/352 (36%), Positives = 168/352 (47%), Gaps = 60/352 (17%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD-----ACQRKP------CQNNASCIDA 367
C KG C K +E+ C C + G +C+ + A R+ CQ++ CI+A
Sbjct: 1072 CKNKGTCVQKKAES--QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINA 1129
Query: 368 NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSAC 427
G+ C C GYTG C+ ++D C +PC++GATC + G+ C+C GY G C
Sbjct: 1130 -----GNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNC 1184
Query: 428 EEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-CAH-GTCRSV 485
E +VD C + PCQN GTC HF C+C PG G C + ID CA P C + G C
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDR 1244
Query: 486 GTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAAT--CRDLVNGYECVCLAEYKGTHCELY 543
Y C C PG+ G CE + NECLS PC + + C L N Y CVC + + G HCE +
Sbjct: 1245 IGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETF 1304
Query: 544 KDPCANVSCLNGATCD-----SDGLNGTCICAPGFTGEECDIDINE-------------- 584
D C + CLNG TC DG C C PGF+G C +
Sbjct: 1305 VDVCPQMPCLNGGTCAVASNMPDGF--ICRCPPGFSGARCQSSCGQVKCRKGEQCVHTAS 1362
Query: 585 ---------------CDSNPCHHGGSC--LDQPNGYNCHCPHGWVGANCEIH 619
C S+PC HGGSC QP Y+C C + G+ CE++
Sbjct: 1363 GPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELY 1414
Score = 230 bits (587), Expect = 3e-60
Identities = 117/347 (33%), Positives = 166/347 (47%), Gaps = 34/347 (9%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C C P+ +++C C + G C + D C KPC N+ C + ++
Sbjct: 842 CENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQ-----GSYM 896
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
C C PG++G C+ ID C+ +PC+NG +C+ ++ F+C C G+ G C+ ++ C S
Sbjct: 897 CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956
Query: 438 PCQNNGTC--YVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCD 494
PC+N GTC YV+ +TC C GF G C I+ C S C +G TC S+ CLC
Sbjct: 957 PCKNGGTCSDYVNS--YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCP 1014
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLN 554
G+ G +C E NEC S PCLN TC D + Y C C Y G +C+ + C+ C N
Sbjct: 1015 VGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKN 1074
Query: 555 GATCDSDGLNGTCICAPGFTGEECDIDINECD----------SNPCHHGGSCLDQPNGYN 604
TC C+C G+ G CD+ CD + C H G C++ N +
Sbjct: 1075 KGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY 1134
Query: 605 CHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFI 651
C CP G+ G+ CE L E +N +H GA C FI
Sbjct: 1135 CQCPLGYTGSYCEEQLD-------ECASNPCQH------GATCSDFI 1168
Score = 226 bits (577), Expect = 4e-59
Identities = 114/312 (36%), Positives = 154/312 (49%), Gaps = 18/312 (5%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C + + TF C C + G+ CE D C CQN C+D + +
Sbjct: 230 CVNGGTCR-QTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGV-----NTYN 283
Query: 378 CVCLPGYTGELCQSKIDYCILDP--CRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
C C P +TG+ C +D C+L P C+NG TC + G+ C C G+ G C E +D CA
Sbjct: 284 CRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCA 343
Query: 436 SSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTC---RSVGTSYKCL 492
+ C TC F+C C G G C L D C +PC G + Y C
Sbjct: 344 FASCTPGSTCIDRVASFSCMCPEGKAGLLC-HLDDACISNPCHKGALCDTNPLNGQYICT 402
Query: 493 CDPGYHGLYCEEEYNECLSA---PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCAN 549
C GY G C E+ +EC A PC +A C + + C CL Y G CE+ + C +
Sbjct: 403 CPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHS 462
Query: 550 VSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCP 608
C N ATC D + G TC+C PGF G C+++INEC SNPC + G C+D+ N + C CP
Sbjct: 463 DPCQNDATC-LDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCP 521
Query: 609 HGWVGANCEIHL 620
G+ G C+I +
Sbjct: 522 PGFTGPVCQIDI 533
Score = 224 bits (570), Expect = 3e-58
Identities = 115/307 (37%), Positives = 160/307 (52%), Gaps = 15/307 (4%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C +G C T + T C C E ++G +C+ D C++ CQN +C+ + TC
Sbjct: 35 CVNEGMCVTYHN-GTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCV---AQAMLGKATC 90
Query: 379 VCLPGYTGELCQSKIDY-CILD-PCRNGATC-ISSLSGFTCQCPEGYFGSACEEKVDPCA 435
C G+TGE CQ + C + PC NG TC + S + C C G+ G C + D C
Sbjct: 91 RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACL 149
Query: 436 SSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL-SPCAH-GTCRSVGTSYKCLC 493
S PC N TC F+C C GFTG C ++ C + C H GTC ++ SY+C C
Sbjct: 150 SHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQC 209
Query: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVN-GYECVCLAEYKGTHCELYKDPCANVSC 552
G+ G YC+ Y C +PC+N TCR + +EC CL ++G+ CE D C N C
Sbjct: 210 PQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRC 269
Query: 553 LNGATCDSDGLNG-TCICAPGFTGEECDIDINEC--DSNPCHHGGSCLDQPNGYNCHCPH 609
NG C DG+N C C P +TG+ C D++EC N C +GG+C ++ GY C C +
Sbjct: 270 QNGGVC-VDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVN 328
Query: 610 GWVGANC 616
GW G +C
Sbjct: 329 GWSGDDC 335
Score = 155 bits (391), Expect = 2e-37
Identities = 79/224 (35%), Positives = 107/224 (47%), Gaps = 42/224 (18%)
Query: 399 DPCRNGATCISSLSGFT-CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV--HFTCN 455
+PC N C++ +G C+CPEG+ G C+ + DPC + CQN GTC + TC
Sbjct: 33 EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCR 91
Query: 456 CSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCL 515
C+ GFTG C TS+ C +S PCL
Sbjct: 92 CASGFTGEDC------------------QYSTSHPCF-----------------VSRPCL 116
Query: 516 NAATCRDLVNG-YECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFT 574
N TC L YEC C + G C+ + D C + C NG+TC + +C C GFT
Sbjct: 117 NGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFT 175
Query: 575 GEECDIDINECD-SNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
G++C+ D+NECD C HGG+CL+ P Y C CP G+ G C+
Sbjct: 176 GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD 219
Score = 152 bits (383), Expect = 1e-36
Identities = 97/317 (30%), Positives = 133/317 (41%), Gaps = 60/317 (18%)
Query: 334 FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
+ C C Y G CE E D CQ +PCQN +CID ++F C C PG G LC+
Sbjct: 1171 YRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLV-----NHFKCSCPPGTRGLLCEEN 1225
Query: 393 IDYCILDP-CRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGT--CYVDG 449
ID C P C NG C+ + G++C+C G+ G CE ++ C S+PC + G+ C
Sbjct: 1226 IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLT 1285
Query: 450 VHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTS----YKCLCDPGYHGLYCEEE 505
+ C C FTG C +D C PC +G +V ++ + C C PG+ G C+
Sbjct: 1286 NDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSS 1345
Query: 506 YNE-----------------------------CLSAPCLNAATCRDLVNG--YECVCLAE 534
+ C S+PC + +C Y C C
Sbjct: 1346 CGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPP 1405
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCH-HG 593
+ G+ CELY P + ATC S CA CD C+S+ C G
Sbjct: 1406 FSGSRCELYTAPPSTPP----ATCLSQ------YCADKARDGVCD---EACNSHACQWDG 1452
Query: 594 GSC-LDQPNGY-NCHCP 608
G C L N + NC P
Sbjct: 1453 GDCSLTMENPWANCSSP 1469
Score = 70.9 bits (172), Expect = 4e-12
Identities = 33/86 (38%), Positives = 42/86 (48%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PCR G C + G G+ C CP G +C + C SNPC HGN
Sbjct: 686 CASNPCRKGATCIN------------GVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGN 733
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
C+ S GY C+C+ G+ G NCE
Sbjct: 734 CTGGLS----GYKCLCDAGWVGINCE 755
Score = 69.7 bits (169), Expect = 9e-12
Identities = 36/90 (40%), Positives = 42/90 (46%), Gaps = 17/90 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C + PC+NGG C + GY CTC G G NCQ+ D CASNPC + G
Sbjct: 761 CLSNPCQNGGTCDNLVN------------GYRCTCKKGFKGYNCQVNIDECASNPCLNQG 808
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
C S GY C C Y G NC+ L
Sbjct: 809 TCFDDIS----GYTCHCVLPYTGKNCQTVL 834
Score = 63.9 bits (154), Expect = 5e-10
Identities = 33/81 (40%), Positives = 42/81 (51%), Gaps = 15/81 (18%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSS 112
C++ GVC + AG Y C CP G +G+ C+ D CASNPC HG ++
Sbjct: 1120 CQHSGVCIN-----------AGNTHY-CQCPLGYTGSYCEEQLDECASNPCQHG---ATC 1164
Query: 113 SSSSDGYLCICNEGYEGPNCE 133
S GY C C GY+G NCE
Sbjct: 1165 SDFIGGYRCECVPGYQGVNCE 1185
Score = 63.5 bits (153), Expect = 7e-10
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 15/89 (16%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HH 105
PC+ PC N VC P + Y+C C G G C + D C S PC +H
Sbjct: 836 PCSPNPCENAAVCKESPNFE----------SYTCLCAPGWQGQRCTIDIDECISKPCMNH 885
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
G C ++ S Y+C C G+ G +CE+
Sbjct: 886 GLCHNTQGS----YMCECPPGFSGMDCEE 910
Score = 59.7 bits (143), Expect = 9e-09
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C A PC+NGG C G +SC C G +G CQ + C S PC +G
Sbjct: 915 CLANPCQNGGSCMD------------GVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGG 962
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S +S Y C C G++G +CE
Sbjct: 963 TCSDYVNS---YTCKCQAGFDGVHCE 985
Score = 59.3 bits (142), Expect = 1e-08
Identities = 28/85 (32%), Positives = 38/85 (44%), Gaps = 13/85 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC N G C GY+C C +G NCQ V PC+ NPC +
Sbjct: 799 CASNPCLNQGTCFDDIS------------GYTCHCVLPYTGKNCQTVLAPCSPNPCENA- 845
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
S + + Y C+C G++G C
Sbjct: 846 AVCKESPNFESYTCLCAPGWQGQRC 870
Score = 58.2 bits (139), Expect = 3e-08
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 16/85 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC +G +C G YSC C G +G C + D CASNPC G
Sbjct: 649 CASNPCIHG-ICMD------------GINRYSCVCSPGFTGQRCNIDIDECASNPCRKG- 694
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
++ + +G+ CIC EG P+C
Sbjct: 695 --ATCINGVNGFRCICPEGPHHPSC 717
Score = 57.8 bits (138), Expect = 4e-08
Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C ++PC N G+C + + Y C CP G SG +C+ D C +NPC +G
Sbjct: 877 CISKPCMNHGLCHNT------------QGSYMCECPPGFSGMDCEEDIDDCLANPCQNG- 923
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S + + C+C G+ G C+
Sbjct: 924 --GSCMDGVNTFSCLCLPGFTGDKCQ 947
Score = 57.0 bits (136), Expect = 6e-08
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C++ PC N G C G Y C+CP G +G NCQ + + C+ +PC + G
Sbjct: 1029 CSSHPCLNEGTCVD------------GLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKG 1076
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + S C+C G+ G C+
Sbjct: 1077 TCVQKKAESQ----CLCPSGWAGAYCD 1099
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 14/94 (14%)
Query: 48 CAAQP-CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
CA P C NGG C R GYSC C G +G C+ + C SNPC
Sbjct: 1229 CARGPHCLNGGQCMDRIG------------GYSCRCLPGFAGERCEGDINECLSNPCSSE 1276
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
++D YLC+C + G +CE + P
Sbjct: 1277 GSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCP 1309
Score = 53.9 bits (128), Expect = 5e-07
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 16/92 (17%)
Query: 43 SAPGPC-AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
S PC ++PC NGG C Y CTC G +G CQ D C S+
Sbjct: 104 STSHPCFVSRPCLNGGTCHM-----------LSRDTYECTCQVGFTGKECQW-TDACLSH 151
Query: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
PC +G S+ ++ ++ + C C G+ G CE
Sbjct: 152 PCANG---STCTTVANQFSCKCLTGFTGQKCE 180
Score = 53.9 bits (128), Expect = 5e-07
Identities = 28/87 (32%), Positives = 37/87 (42%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C C NGG C G +SC CP G +G+ C + C+S+PC + G
Sbjct: 991 CTESSCFNGGTCVD------------GINSFSCLCPVGFTGSFCLHEINECSSHPCLNEG 1038
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + Y C C GY G NC+
Sbjct: 1039 TCVDGLGT----YRCSCPLGYTGKNCQ 1061
Score = 52.4 bits (124), Expect = 2e-06
Identities = 18/58 (31%), Positives = 31/58 (53%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Y C C + +G +C+ D C PC +G + +S+ DG++C C G+ G C+ +
Sbjct: 1288 YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSS 1345
Score = 50.8 bits (120), Expect = 4e-06
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C ++PC+NGG C+ Y+C C AG G +C+ + C + C +G
Sbjct: 953 CLSEPCKNGGTCSDYVN------------SYTCKCQAGFDGVHCENNINECTESSCFNGG 1000
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
+S + C+C G+ G C
Sbjct: 1001 TCVDGINS---FSCLCPVGFTGSFC 1022
Score = 50.1 bits (118), Expect = 8e-06
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC++G C+ GY C C G G NC+ D C + PC +G
Sbjct: 1153 CASNPCQHGATCSDFIG------------GYRCECVPGYQGVNCEYEVDECQNQPCQNG- 1199
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ + + C C G G CE+
Sbjct: 1200 --GTCIDLVNHFKCSCPPGTRGLLCEE 1224
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/87 (32%), Positives = 34/87 (39%), Gaps = 16/87 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP-CHHG 106
C QPC+NGG C + C+CP G G C+ D CA P C +G
Sbjct: 1191 CQNQPCQNGGTCIDLVNH------------FKCSCPPGTRGLLCEENIDDCARGPHCLNG 1238
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
GY C C G+ G CE
Sbjct: 1239 ---GQCMDRIGGYSCRCLPGFAGERCE 1262
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/125 (30%), Positives = 42/125 (33%), Gaps = 43/125 (34%)
Query: 48 CAAQPCRNGGVCTSRPE-PDPQHPAPAGEPGYSCTCPAGISGANCQ-------------- 92
C PC NGG C PD G+ C CP G SGA CQ
Sbjct: 1308 CPQMPCLNGGTCAVASNMPD----------GFICRCPPGFSGARCQSSCGQVKCRKGEQC 1357
Query: 93 --LVADP-------------CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE--QA 135
+ P CAS+PC HG S Y C C + G CE A
Sbjct: 1358 VHTASGPRCFCPSPRDCESGCASSPCQHGG-SCHPQRQPPYYSCQCAPPFSGSRCELYTA 1416
Query: 136 LPSLP 140
PS P
Sbjct: 1417 PPSTP 1421
Score = 47.4 bits (111), Expect = 5e-05
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 14/88 (15%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PCA PC NGG C G+ + C C G G+ C+ D C ++ C +G
Sbjct: 224 PCAPSPCVNGGTCRQ-----------TGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNG 272
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
++ Y C C + G C +
Sbjct: 273 GVCVDGVNT---YNCRCPPQWTGQFCTE 297
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 24/112 (21%)
Query: 40 APLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP-- 97
+P CA+ PC++GG C + +P P YSC C SG+ C+L P
Sbjct: 1370 SPRDCESGCASSPCQHGGSCHPQRQP----------PYYSCQCAPPFSGSRCELYTAPPS 1419
Query: 98 -----CASNPC----HHGNCSSSSSSSS---DGYLCICNEGYEGPNCEQALP 137
C S C G C + +S + DG C NC LP
Sbjct: 1420 TPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLP 1471
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 13/83 (15%)
Query: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSS 110
+PC N G+C + GY C CP G G CQ DPC N C +G
Sbjct: 33 EPCVNEGMCVTYHNGT----------GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCV 80
Query: 111 SSSSSSDGYLCICNEGYEGPNCE 133
+ + C C G+ G +C+
Sbjct: 81 AQAMLGKA-TCRCASGFTGEDCQ 102
Score = 38.9 bits (89), Expect = 0.017
Identities = 43/164 (26%), Positives = 55/164 (33%), Gaps = 20/164 (12%)
Query: 311 ESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEK 370
ES C G C + +SC C + G+ CE Y A P S A++
Sbjct: 1375 ESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKA 1434
Query: 371 QDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEK 430
+DG VC CQ C L A C S L + Y + C+E
Sbjct: 1435 RDG-----VCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW------DYINNQCDEL 1483
Query: 431 VDPCA----SSPCQNNG-TCYVD---GVHFTCN-CSPGFTGPTC 465
+ + CQ N TC D HF N C G C
Sbjct: 1484 CNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEEC 1527
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 272 bits (696), Expect = 7e-73
Identities = 124/300 (41%), Positives = 167/300 (55%), Gaps = 11/300 (3%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C GKC + +F C C + Y G CE + + C PCQN+A+C+D Q G F
Sbjct: 423 CEHAGKCIN--TLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLD----QIGE-FQ 475
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
C+C+PGY G C+ D C PC + C+ ++ F C+CP G+ G C+ VD CAS+
Sbjct: 476 CICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAST 535
Query: 438 PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497
PC+N C +TC C+ G+TG C ID C PC +G+C+ ++ CLC PGY
Sbjct: 536 PCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGY 595
Query: 498 HGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGAT 557
G +CE NEC S PC + TC+D N Y C CL G +CE+ D CA+ C +G
Sbjct: 596 TGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTC 655
Query: 558 CDS-DGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
D DG C C PG+TG C+I+I+EC NPCH+GG+C D NG+ C CP G+ C
Sbjct: 656 LDKIDGYE--CACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTC 713
Score = 270 bits (689), Expect = 5e-72
Identities = 135/360 (37%), Positives = 176/360 (48%), Gaps = 52/360 (14%)
Query: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
TC+ + N C G C + S + C C+ + GT C+ + C+ PC N +C
Sbjct: 712 TCLSEVNECNSNPCV-HGAC--RDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTC 768
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG 424
D S + C C G++G CQ+ I+ C +PC N TCI ++G+ C C Y G
Sbjct: 769 KDMT-----SGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTG 823
Query: 425 SACEEKVDPCASSPCQNNGTCYV--DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-T 481
+ CE + PCA SPC+N G C D F+C C G+ G TC I+ C LSPC HG +
Sbjct: 824 ATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGAS 883
Query: 482 CRSVGTSYKCLCD--------------------------------------PGYHGLYCE 503
C++ Y+C C PG+ G +CE
Sbjct: 884 CQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCE 943
Query: 504 EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGL 563
E+ NEC S PC N A C D V+ Y C C A + G HCE C SC NG TC DG+
Sbjct: 944 EDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTC-VDGI 1002
Query: 564 NG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQW 622
N TC+C PGFTG C D+NECDS PC HGG+C D Y C CP G+ G NC+ + W
Sbjct: 1003 NSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHW 1062
Score = 266 bits (679), Expect = 7e-71
Identities = 132/358 (36%), Positives = 172/358 (48%), Gaps = 59/358 (16%)
Query: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQN 360
V + C P H G C K ATF+C C Y G CE + C +PC++
Sbjct: 565 VDIDECDPDPCHY--------GSC--KDGVATFTCLCRPGYTGHHCETNINECSSQPCRH 614
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
+C D + + C CL G TG C+ +D C PC +G TC+ + G+ C C
Sbjct: 615 GGTCQDRDNA-----YLCFCLKGTTGPNCEINLDDCASSPCDSG-TCLDKIDGYECACEP 668
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAH 479
GY GS C +D CA +PC N GTC DG++ FTC C G+ PTC ++ C +PC H
Sbjct: 669 GYTGSMCNINIDECAGNPCHNGGTCE-DGINGFTCRCPEGYHDPTCLSEVNECNSNPCVH 727
Query: 480 GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDL---------------- 523
G CR YKC CDPG+ G C+ NEC S PC+N TC+D+
Sbjct: 728 GACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPN 787
Query: 524 ----------------------VNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC--D 559
V GY+C CL Y G CE+ PCA C NG C
Sbjct: 788 CQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQS 847
Query: 560 SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
D + +C+C G+ G+ C++DINEC +PC HG SC + GY CHC G+ G NCE
Sbjct: 848 EDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCE 905
Score = 261 bits (666), Expect = 2e-69
Identities = 128/318 (40%), Positives = 161/318 (50%), Gaps = 11/318 (3%)
Query: 310 GESHANDLECSGKGKC----TTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCI 365
GE + +++ C T A+F C C G C DAC PC ++C
Sbjct: 329 GEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNC- 387
Query: 366 DANEKQDGSNFTCVCLPGYTGELCQSKIDYCIL--DPCRNGATCISSLSGFTCQCPEGYF 423
D N + C C GYTG C +D C L +PC + CI++L F CQC +GY
Sbjct: 388 DTNPVNGKA--ICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT 445
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTC 482
G CE V+ C S+PCQN+ TC F C C PG+ G C D CA SPC H G C
Sbjct: 446 GPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRC 505
Query: 483 RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCEL 542
++C C G+ G C+ + +EC S PC N A C D N Y CVC Y GTHCE+
Sbjct: 506 LDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEV 565
Query: 543 YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
D C C G +C TC+C PG+TG C+ +INEC S PC HGG+C D+ N
Sbjct: 566 DIDECDPDPCHYG-SCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNA 624
Query: 603 YNCHCPHGWVGANCEIHL 620
Y C C G G NCEI+L
Sbjct: 625 YLCFCLKGTTGPNCEINL 642
Score = 251 bits (640), Expect = 2e-66
Identities = 123/315 (39%), Positives = 166/315 (52%), Gaps = 21/315 (6%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFT 377
C G CT + A C C + GTFCEE + C PC+N A+C D + ++T
Sbjct: 916 CHNGGSCTDGINTAF--CDCLPGFRGTFCEEDINECASDPCRNGANCTDCVD-----SYT 968
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
C C G++G C++ C C NG TC+ ++ FTC CP G+ GS C+ V+ C S
Sbjct: 969 CTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQ 1028
Query: 438 PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPG 496
PC + GTC + C C G+TGP C L+ +C SPC +G C T Y+C C G
Sbjct: 1029 PCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSG 1088
Query: 497 YHGLYCEEEYNECLSAP----------CLNAATCRDLVNGYECVCLAEYKGTHCELYKDP 546
+ GLYC+ C A C + C D N + C C A Y G++CE D
Sbjct: 1089 WTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDE 1148
Query: 547 CANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNC 605
C+ C NGATC +D L G +C C G+ G C +I+EC S+PC +GG+CLD PN Y C
Sbjct: 1149 CSPSPCQNGATC-TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKC 1207
Query: 606 HCPHGWVGANCEIHL 620
CP G G +CEI++
Sbjct: 1208 SCPRGTQGVHCEINV 1222
Score = 247 bits (630), Expect = 3e-65
Identities = 119/322 (36%), Positives = 167/322 (51%), Gaps = 15/322 (4%)
Query: 313 HANDL----ECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQ--RKPCQNNASCI 365
H ND C+ C T P CTC Y G C ++ D C PC++ CI
Sbjct: 371 HLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCI 430
Query: 366 DANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGS 425
+ +F C CL GYTG C+ ++ C+ +PC+N ATC+ + F C C GY G
Sbjct: 431 NTL-----GSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV 485
Query: 426 ACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT-CRS 484
CE D CASSPC +NG C F C C GFTG C +D CA +PC +G C
Sbjct: 486 HCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLD 545
Query: 485 VGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK 544
+Y C+C GY G +CE + +EC PC + +C+D V + C+C Y G HCE
Sbjct: 546 GPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNI 604
Query: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYN 604
+ C++ C +G TC C C G TG C+I++++C S+PC G+CLD+ +GY
Sbjct: 605 NECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCD-SGTCLDKIDGYE 663
Query: 605 CHCPHGWVGANCEIHLQWKSGH 626
C C G+ G+ C I++ +G+
Sbjct: 664 CACEPGYTGSMCNINIDECAGN 685
Score = 243 bits (619), Expect = 6e-64
Identities = 120/317 (37%), Positives = 176/317 (55%), Gaps = 20/317 (6%)
Query: 309 PGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDAN 368
PGE+ C GKC + + T +C C +VG C++ + C PC+N +C
Sbjct: 27 PGET------CLNGGKC--EAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTC-HVV 77
Query: 369 EKQDGSNFTCVCLPGYTGELCQSKID-YCILDPCRNGATC-ISSLSGFTCQCPEGYFGSA 426
+++ +++ C C G++G LC + +D C+ +PCRNG TC + +L+ + C+CP G+ G +
Sbjct: 78 DRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKS 137
Query: 427 CEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP--CAH-GTCR 483
C++ DPCAS+PC N G C + C+C P F GPTC Q ++ C P C H GTC
Sbjct: 138 CQQ-ADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCH 196
Query: 484 SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVN-GYECVCLAEYKGTHCEL 542
+ SY+C+C + G CE Y C +PC N TCR + +EC CL + G +CE
Sbjct: 197 NEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEE 256
Query: 543 YKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECD--SNPCHHGGSCLDQ 599
D C +C NG C DG+N C C P +TG+ C D++EC N C +GG+C +
Sbjct: 257 NIDDCPGNNCKNGGAC-VDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNT 315
Query: 600 PNGYNCHCPHGWVGANC 616
GYNC C +GW G +C
Sbjct: 316 HGGYNCVCVNGWTGEDC 332
Score = 207 bits (527), Expect = 3e-53
Identities = 112/324 (34%), Positives = 148/324 (45%), Gaps = 32/324 (9%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD-----ACQRKP------CQNNASCIDA 367
C GKC ++ + C C + G +C+ A QR+ CQ+ C+DA
Sbjct: 1068 CKNGGKCWQTHTQ--YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDA 1125
Query: 368 NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSAC 427
G+ C C GYTG C+ +D C PC+NGATC L G++C+C GY G C
Sbjct: 1126 -----GNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNC 1180
Query: 428 EEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFC--ALSPCA------- 478
E++D C S PCQN GTC + C+C G G C +D C + P +
Sbjct: 1181 SEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFN 1240
Query: 479 HGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAAT--CRDLVNGYECVCLAEYK 536
+GTC Y C C PG+ G CE + NECLS PC T C VN + C C A +
Sbjct: 1241 NGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHT 1300
Query: 537 GTHCELYKDPCANVSCLNGATC---DSDGLNGTCICAPGFTGEECDIDINECDSNPCHHG 593
G CE + C C NG TC + C C GF G C+ D C S C +G
Sbjct: 1301 GRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNG 1360
Query: 594 GSCLDQPNGYNCHCPHGWVGANCE 617
G+C+ P C C + G C+
Sbjct: 1361 GTCISGPRSPTCLCLGPFTGPECQ 1384
Score = 90.5 bits (223), Expect = 5e-18
Identities = 95/383 (24%), Positives = 133/383 (34%), Gaps = 114/383 (29%)
Query: 302 VKVSTCVPG-ESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQ 359
+ V C P + + +C G C + +SCTC +VG CE + + C PC
Sbjct: 1220 INVDDCNPPVDPVSRSPKCFNNGTCVDQVGG--YSCTCPPGFVGERCEGDVNECLSNPCD 1277
Query: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCI---SSLSGFTC 416
+ N Q ++F C C G+TG C+S I+ C PC+NG TC ++ GF C
Sbjct: 1278 ARGT---QNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFIC 1334
Query: 417 QCPEGYFGSACEEKVDPC----------------------------------ASSPCQNN 442
+CP G+ G+ CE C ASSPC
Sbjct: 1335 KCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGG 1394
Query: 443 GTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYC 502
CY G C P P Y+CLC ++GL C
Sbjct: 1395 NPCYNQG-----TCEPTSESP------------------------FYRCLCPAKFNGLLC 1425
Query: 503 E-EEYN----------------ECLSAPCLNAA---TCRDLVNGYECVCLAEYKGTHCEL 542
+Y+ C C A C N + C + G C L
Sbjct: 1426 HILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHAC----GWDGGDCSL 1481
Query: 543 -YKDPCAN----VSC---LNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGG 594
+ DP N + C + CDS + C+ F G +C +C NP +
Sbjct: 1482 NFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCL----FDGFDCQRAEGQC--NPL-YDQ 1534
Query: 595 SCLDQPNGYNCHCPHGWVGANCE 617
C D + + HC G A CE
Sbjct: 1535 YCKDHFS--DGHCDQGCNSAECE 1555
Score = 73.9 bits (180), Expect = 5e-13
Identities = 33/87 (37%), Positives = 43/87 (49%), Gaps = 13/87 (14%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PCA PCRNGG C + + +SC CP G G C++ + C +PC HG
Sbjct: 832 PCAPSPCRNGGECRQSEDYE----------SFSCVCPTGWQGQTCEVDINECVLSPCRHG 881
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
+S ++ GY C C GY G NCE
Sbjct: 882 ---ASCQNTHGGYRCHCQAGYSGRNCE 905
Score = 69.7 bits (169), Expect = 9e-12
Identities = 41/111 (36%), Positives = 49/111 (44%), Gaps = 28/111 (25%)
Query: 48 CAAQPCRNGGVC-------TSR-PEP--DPQHPAPAGE---------------PGYSCTC 82
CA PC NGG C T R PE DP + E GY C C
Sbjct: 682 CAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDC 741
Query: 83 PAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G SG NC + + C SNPC +G +S GY+C C EG+ GPNC+
Sbjct: 742 DPGWSGTNCDINNNECESNPCVNGGTCKDMTS---GYVCTCREGFSGPNCQ 789
Score = 68.6 bits (166), Expect = 2e-11
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC+NG C P Y+C C G +G +C++ D C +PCH+G+
Sbjct: 532 CASTPCKNGAKCLDGPNT------------YTCVCTEGYTGTHCEVDIDECDPDPCHYGS 579
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
C ++ + C+C GY G +CE
Sbjct: 580 CKDGVAT----FTCLCRPGYTGHHCE 601
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/102 (38%), Positives = 47/102 (46%), Gaps = 19/102 (18%)
Query: 34 ANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL 93
+ P+ PL C PCRNGG C + Y C CP G SG +CQ
Sbjct: 94 SGPLCLTPLD--NACLTNPCRNGGTCDLLTLTE-----------YKCRCPPGWSGKSCQ- 139
Query: 94 VADPCASNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
ADPCASNPC + G C +S Y+C C + GP C Q
Sbjct: 140 QADPCASNPCANGGQCLPFEAS----YICHCPPSFHGPTCRQ 177
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 28/110 (25%)
Query: 48 CAAQPCRNGGVCTSRP--------------------EPDPQHPAPAGE-----PGYSCTC 82
C++QPCR+GG C R + P +G GY C C
Sbjct: 607 CSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECAC 666
Query: 83 PAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNC 132
G +G+ C + D CA NPCH+G + +G+ C C EGY P C
Sbjct: 667 EPGYTGSMCNINIDECAGNPCHNG---GTCEDGINGFTCRCPEGYHDPTC 713
Score = 64.3 bits (155), Expect = 4e-10
Identities = 37/96 (38%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C + PC NGG C GY CTC G SG NCQ + CASNPC + G
Sbjct: 757 CESNPCVNGGTCKDMTS------------GYVCTCREGFSGPNCQTNINECASNPCLNQG 804
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQAL-PSLPA 141
C + GY C C Y G CE L P P+
Sbjct: 805 TCIDDVA----GYKCNCLLPYTGATCEVVLAPCAPS 836
Score = 63.9 bits (154), Expect = 5e-10
Identities = 30/86 (34%), Positives = 37/86 (43%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C C NGG C G ++C CP G +G+ CQ + C S PC HG
Sbjct: 987 CTESSCFNGGTCVD------------GINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGG 1034
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S Y C C +GY GPNC+
Sbjct: 1035 TCQDGCGS---YRCTCPQGYTGPNCQ 1057
Score = 62.4 bits (150), Expect = 1e-09
Identities = 29/86 (33%), Positives = 39/86 (45%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC + G C + + C CP G +G CQ D CAS PC +G
Sbjct: 494 CASSPCLHNGRCLDKINE------------FQCECPTGFTGHLCQYDVDECASTPCKNG- 540
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ + Y C+C EGY G +CE
Sbjct: 541 --AKCLDGPNTYTCVCTEGYTGTHCE 564
Score = 61.6 bits (148), Expect = 2e-09
Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 13/86 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC N G C GY C C +GA C++V PCA +PC +G
Sbjct: 795 CASNPCLNQGTCID------------DVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGG 842
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S + + C+C G++G CE
Sbjct: 843 -ECRQSEDYESFSCVCPTGWQGQTCE 867
Score = 60.1 bits (144), Expect = 7e-09
Identities = 32/98 (32%), Positives = 41/98 (41%), Gaps = 19/98 (19%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP--CH 104
PCA+ PC NGG C E Y C CP G C+ + C P C
Sbjct: 143 PCASNPCANGGQCLPF------------EASYICHCPPSFHGPTCRQDVNECGQKPGLCR 190
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPAT 142
HG + S Y C+C + GPNCE+ P +P +
Sbjct: 191 HGGTCHNEVGS---YRCVCRATHTGPNCER--PYVPCS 223
Score = 59.7 bits (143), Expect = 9e-09
Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PCRNG CT + Y+CTCPAG SG +C+ C + C +G
Sbjct: 949 CASDPCRNGANCTDCVD------------SYTCTCPAGFSGIHCENNTPDCTESSCFNGG 996
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+S + C+C G+ G C+
Sbjct: 997 TCVDGINS---FTCLCPPGFTGSYCQ 1019
Score = 59.7 bits (143), Expect = 9e-09
Identities = 30/86 (34%), Positives = 38/86 (44%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ PC+NG CT GYSC C AG G NC D C S+PC +G
Sbjct: 1149 CSPSPCQNGATCTDYLG------------GYSCKCVAGYHGVNCSEEIDECLSHPCQNGG 1196
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
++ Y C C G +G +CE
Sbjct: 1197 TCLDLPNT---YKCSCPRGTQGVHCE 1219
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/87 (34%), Positives = 40/87 (45%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-G 106
C +QPC +GG C G Y CTCP G +G NCQ + C S+PC + G
Sbjct: 1025 CDSQPCLHGGTCQD------------GCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGG 1072
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + + Y C C G+ G C+
Sbjct: 1073 KCWQTHTQ----YRCECPSGWTGLYCD 1095
Score = 56.2 bits (134), Expect = 1e-07
Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 17/89 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCA--SNPCHH 105
C + PC G C + P CTCP+G +G C D C+ +NPC H
Sbjct: 376 CISNPCNEGSNCDTNPVNGKA----------ICTCPSGYTGPACSQDVDECSLGANPCEH 425
Query: 106 -GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G C ++ S + C C +GY GP CE
Sbjct: 426 AGKCINTLGS----FECQCLQGYTGPRCE 450
Score = 56.2 bits (134), Expect = 1e-07
Identities = 31/91 (34%), Positives = 38/91 (41%), Gaps = 17/91 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG- 106
C PC NGG CT G C C G G C+ + CAS+PC +G
Sbjct: 911 CRPNPCHNGGSCTD------------GINTAFCDCLPGFRGTFCEEDINECASDPCRNGA 958
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
NC + D Y C C G+ G +CE P
Sbjct: 959 NC----TDCVDSYTCTCPAGFSGIHCENNTP 985
Score = 55.5 bits (132), Expect = 2e-07
Identities = 30/87 (34%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C +PC+NGG C A G+ C CPAG GA C+ A C S C + G
Sbjct: 1311 CKGKPCKNGGTCAV---------ASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGG 1361
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C S S + C+C + GP C+
Sbjct: 1362 TCISGPRSPT----CLCLGPFTGPECQ 1384
Score = 54.7 bits (130), Expect = 3e-07
Identities = 20/56 (35%), Positives = 33/56 (58%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+ C C AG +G C+ V + C PC +G + +S+++ G++C C G+EG CE
Sbjct: 1291 FHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCE 1346
Score = 54.3 bits (129), Expect = 4e-07
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 14/88 (15%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PC+ PC+NGG C P G+ + C C G +G NC+ D C N C +G
Sbjct: 221 PCSPSPCQNGGTCR-----------PTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNG 269
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
++ Y C C + G C +
Sbjct: 270 GACVDGVNT---YNCRCPPEWTGQYCTE 294
Score = 54.3 bits (129), Expect = 4e-07
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 15/91 (16%)
Query: 46 GPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105
G A+ C++GG+C AG + C C AG +G+ C+ + D C+ +PC +
Sbjct: 1109 GVDVARLCQHGGLCVD-----------AGNT-HHCRCQAGYTGSYCEDLVDECSPSPCQN 1156
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
G ++ + GY C C GY G NC + +
Sbjct: 1157 G---ATCTDYLGGYSCKCVAGYHGVNCSEEI 1184
Score = 53.9 bits (128), Expect = 5e-07
Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 25/95 (26%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--------A 99
C + PC+NGG C P Y C+CP G G +C++ D C
Sbjct: 1187 CLSHPCQNGGTCLDLPNT------------YKCSCPRGTQGVHCEINVDDCNPPVDPVSR 1234
Query: 100 SNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
S C ++G C GY C C G+ G CE
Sbjct: 1235 SPKCFNNGTCVDQVG----GYSCTCPPGFVGERCE 1265
Score = 53.5 bits (127), Expect = 7e-07
Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 16/88 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG- 106
CA+ C +G C R + C CP G +G C L D C SNPC+ G
Sbjct: 339 CASAACFHGATCHDRVA------------SFYCECPHGRTGLLCHL-NDACISNPCNEGS 385
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
NC ++ + +C C GY GP C Q
Sbjct: 386 NCDTNPVNGKA--ICTCPSGYTGPACSQ 411
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/84 (28%), Positives = 36/84 (42%), Gaps = 15/84 (17%)
Query: 50 AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCS 109
A PC + G C + + C C G +G C++ + C SNPC +
Sbjct: 420 ANPCEHAGKCINTLG------------SFECQCLQGYTGPRCEIDVNECVSNPCQN---D 464
Query: 110 SSSSSSSDGYLCICNEGYEGPNCE 133
++ + CIC GYEG +CE
Sbjct: 465 ATCLDQIGEFQCICMPGYEGVHCE 488
Score = 43.9 bits (102), Expect = 5e-04
Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 19/88 (21%)
Query: 48 CAAQP--CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105
C P C+NGG C + GY+C C G +G +C D CAS C H
Sbjct: 299 CQLMPNACQNGGTCHNT------------HGGYNCVCVNGWTGEDCSENIDDCASAACFH 346
Query: 106 G-NCSSSSSSSSDGYLCICNEGYEGPNC 132
G C +S + C C G G C
Sbjct: 347 GATCHDRVAS----FYCECPHGRTGLLC 370
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 25/96 (26%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--------- 98
C + PC+NGG C Y C CP+G +G C + + C
Sbjct: 1063 CDSSPCKNGGKCWQT------------HTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGV 1110
Query: 99 -ASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+ C HG + ++ + C C GY G CE
Sbjct: 1111 DVARLCQHGGLCVDAGNT---HHCRCQAGYTGSYCE 1143
Score = 34.7 bits (78), Expect = 0.33
Identities = 25/109 (22%), Positives = 34/109 (31%), Gaps = 24/109 (22%)
Query: 38 PAAPLSAPGPC-AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL--- 93
P A PC PC N G C E P Y C CPA +G C +
Sbjct: 1381 PECQFPASSPCLGGNPCYNQGTCEPTSE----------SPFYRCLCPAKFNGLLCHILDY 1430
Query: 94 ---------VADPCASNPCHHGNCSSSSSSSSDGYLCICNE-GYEGPNC 132
+ P C C + + C + G++G +C
Sbjct: 1431 SFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDC 1479
Score = 33.9 bits (76), Expect = 0.56
Identities = 52/215 (24%), Positives = 71/215 (33%), Gaps = 55/215 (25%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD------------------ACQRKPCQN 360
C +G C + C C ++ G C D AC+ CQ
Sbjct: 1397 CYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQE 1456
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
+A + +N C G+ G C + DP +N C SL QC +
Sbjct: 1457 DAG--NKVCSLQCNNHAC----GWDGGDCSLNFN----DPWKN---CTQSL-----QCWK 1498
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
+ C+ S C N+ C DG F C + G C L D + G
Sbjct: 1499 YFSDGHCD--------SQC-NSAGCLFDG--FDCQRAEG----QCNPLYDQYCKDHFSDG 1543
Query: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCL 515
C S +C D GL C E E L+A L
Sbjct: 1544 HCDQGCNSAECEWD----GLDCAEHVPERLAAGTL 1574
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 269 bits (688), Expect = 6e-72
Identities = 128/326 (39%), Positives = 172/326 (52%), Gaps = 22/326 (6%)
Query: 304 VSTCVPG-----------ESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYD 351
+ TC PG E C G+C ++ +F C C Y G CE + +
Sbjct: 376 ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVN--TQGSFLCQCGRGYTGPRCETDVN 433
Query: 352 ACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL 411
C PC+N A+C+D FTC+C+ G+TG C+ ID C PC NG C +
Sbjct: 434 ECLSGPCRNQATCLDRI-----GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRV 488
Query: 412 SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDF 471
+GF+C CP G+ GS C+ VD CAS+PC+N C + C C+ GF G C + +D
Sbjct: 489 NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDD 548
Query: 472 CALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531
C+ PC HG C S+ C C PGY G CE + +EC S PC + C DLV+ Y C C
Sbjct: 549 CSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC 608
Query: 532 LAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPC 590
+ G +CE+ D CA+ C G DG+N C+C PGFTG C+++INEC S+PC
Sbjct: 609 PSGTTGVNCEVNIDDCASNPCTFGVC--RDGINRYDCVCQPGFTGPLCNVEINECASSPC 666
Query: 591 HHGGSCLDQPNGYNCHCPHGWVGANC 616
GGSC+D NG+ C CP G + C
Sbjct: 667 GEGGSCVDGENGFRCLCPPGSLPPLC 692
Score = 257 bits (657), Expect = 2e-68
Identities = 128/329 (38%), Positives = 177/329 (53%), Gaps = 27/329 (8%)
Query: 307 CVPG------ESHANDL---ECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRK 356
C+PG E + +D C G C + T++C C ++ G FC E+ D CQ +
Sbjct: 224 CLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN--TYNCQCPPEWTGQFCTEDVDECQLQ 281
Query: 357 P--CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF 414
P C N +C + +CVC+ G+TGE C ID C C +GATC ++ F
Sbjct: 282 PNACHNGGTCFNTL-----GGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASF 336
Query: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH--FTCNCSPGFTGPTCAQLIDFC 472
C CP G G C D C S+PC + C + V+ C C PGFTG C Q +D C
Sbjct: 337 YCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDEC 395
Query: 473 AL--SPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529
++ +PC H G C + S+ C C GY G CE + NECLS PC N ATC D + + C
Sbjct: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
Query: 530 VCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSN 588
+C+A + GT+CE+ D C + C+NG C D +NG +C C GF+G C +D++EC S
Sbjct: 456 ICMAGFTGTYCEVDIDECQSSPCVNGGVC-KDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
Query: 589 PCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
PC +G C+DQP+GY C C G+ G C+
Sbjct: 515 PCRNGAKCVDQPDGYECRCAEGFEGTLCD 543
Score = 249 bits (636), Expect = 6e-66
Identities = 121/318 (38%), Positives = 161/318 (50%), Gaps = 11/318 (3%)
Query: 310 GESHANDLECSGKGKC----TTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCI 365
GES + +++ C T A+F C C G C DAC PC +A C
Sbjct: 308 GESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAIC- 366
Query: 366 DANEKQDGSNFTCVCLPGYTGELCQSKIDYCIL--DPCRNGATCISSLSGFTCQCPEGYF 423
D N + C C PG+TG C +D C + +PC + C+++ F CQC GY
Sbjct: 367 DTNPVNGRA--ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TC 482
G CE V+ C S PC+N TC FTC C GFTG C ID C SPC +G C
Sbjct: 425 GPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC 484
Query: 483 RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCEL 542
+ + C C G+ G C+ + +EC S PC N A C D +GYEC C ++GT C+
Sbjct: 485 KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544
Query: 543 YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
D C+ C +G D + +C CAPG+TG C+ ++EC S PC HGG CLD +
Sbjct: 545 NVDDCSPDPCHHGRCVDGIA-SFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603
Query: 603 YNCHCPHGWVGANCEIHL 620
Y C CP G G NCE+++
Sbjct: 604 YLCRCPSGTTGVNCEVNI 621
Score = 240 bits (613), Expect = 3e-63
Identities = 115/323 (35%), Positives = 155/323 (47%), Gaps = 18/323 (5%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEAT---------FSCTCEEQYVGTFCEEYDACQRKP 357
C PG S + + C ++P A F CTC G CE C P
Sbjct: 720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
Query: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD-PCRNGATCISSLSGFTC 416
C++ C E G C C G+ G CQ +D C PC C + F+C
Sbjct: 780 CEHGGRC----ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
Query: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCAQLIDFCALS 475
C GY G +C++ ++ C +PC N G+C DGV F+C+C PGF GP CA+ +D C +
Sbjct: 836 TCHGGYTGPSCDQDINDCDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCARDVDECLSN 894
Query: 476 PCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEY 535
PC GTC S+ C C PGY G +CE++ +C + C N TC D VN + C+C Y
Sbjct: 895 PCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY 954
Query: 536 KGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595
G HC+ DPC + CL+G C + C C FTG +C ++ C PC +GG
Sbjct: 955 TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGR 1014
Query: 596 CLDQPNGYNCHCPHGWVGANCEI 618
C+ G C CP GW G C+I
Sbjct: 1015 CVQ--TGAYCLCPPGWSGRLCDI 1035
Score = 239 bits (610), Expect = 7e-63
Identities = 125/347 (36%), Positives = 165/347 (47%), Gaps = 52/347 (14%)
Query: 319 CSGKGKCTTK--PSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNF 376
C+G+G C + A FSC C + G C D C PC + A C + DG F
Sbjct: 87 CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARC---SVGPDG-RF 142
Query: 377 TCVCLPGYTGELCQSKIDYC-ILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
C C PGY G C+S +D C + +PCR+G TC+++ F CQCP GY G CE PCA
Sbjct: 143 LCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCA 202
Query: 436 SSPCQNNGTCYVDG-VHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLC 493
SPC+N GTC G + + C C PGF G C +D C C + GTC +Y C C
Sbjct: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262
Query: 494 DPGYHGLYCEEEYNECLSAP--CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVS 551
P + G +C E+ +EC P C N TC + + G+ CVC+ + G C D CA
Sbjct: 263 PPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV 322
Query: 552 CLNGAT-------------------------------------CDSDGLNG--TCICAPG 572
C +GAT CD++ +NG C C PG
Sbjct: 323 CFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPG 382
Query: 573 FTGEECDIDINECD--SNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
FTG CD D++EC +NPC H G C++ + C C G+ G CE
Sbjct: 383 FTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Score = 235 bits (599), Expect = 1e-61
Identities = 123/355 (34%), Positives = 159/355 (44%), Gaps = 58/355 (16%)
Query: 314 ANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQD 372
A C G CT +FSCTC Y G C++ + C PC N SC QD
Sbjct: 815 AGPAPCGPHGICTNLAG--SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC------QD 866
Query: 373 G-SNFTCVCLPGYTGELCQSKIDYCILDPCR----------------------------- 402
G +F+C CLPG+ G C +D C+ +PC
Sbjct: 867 GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP 926
Query: 403 --------NGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTC 454
NG TC+ ++ F+C C GY G+ C+ + DPC S PC + G C F C
Sbjct: 927 DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986
Query: 455 NCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAP- 513
C FTGP C L+D+C+ PC +G R V T CLC PG+ G C+ C A
Sbjct: 987 TCLESFTGPQCQTLVDWCSRQPCQNGG-RCVQTGAYCLCPPGWSGRLCDIRSLPCREAAA 1045
Query: 514 ---------CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLN 564
C C D + + CVC G+HCE DPC C +G TC
Sbjct: 1046 QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGG 1105
Query: 565 GTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIH 619
C C PG+ G+ C+ D++EC S PC HGGSC+D Y C CP G +G CEI+
Sbjct: 1106 YMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEIN 1160
Score = 226 bits (575), Expect = 8e-59
Identities = 125/344 (36%), Positives = 171/344 (49%), Gaps = 46/344 (13%)
Query: 306 TCVPGESH---ANDL-EC----SGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRK 356
+C+PG + A D+ EC G G CT A+F+CTC Y G CE+ C
Sbjct: 874 SCLPGFAGPRCARDVDECLSNPCGPGTCTDHV--ASFTCTCPPGYGGFHCEQDLPDCSPS 931
Query: 357 PCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTC 416
C N +C+D ++F+C+C PGYTG CQ + D C+ PC +G C ++ GF C
Sbjct: 932 SCFNGGTCVDGV-----NSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986
Query: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP 476
C E + G C+ VD C+ PCQN G C G + C C PG++G C D +L P
Sbjct: 987 TCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--CLCPPGWSGRLC----DIRSL-P 1039
Query: 477 C----------------AHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATC 520
C A G C +S+ C+C G G +CE+E + CL+ PC + TC
Sbjct: 1040 CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099
Query: 521 RDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDI 580
R + GY C CL Y G +CE D CA+ C +G +C C C PG G C+I
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
Query: 581 DINEC------DSNP-CHHGGSCLDQPNGYNCHCPHGWVGANCE 617
+ ++C DS P C H G+C+D G+ C CP G+ G CE
Sbjct: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Score = 225 bits (573), Expect = 1e-58
Identities = 120/325 (36%), Positives = 162/325 (49%), Gaps = 18/325 (5%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY---DACQRKPCQNNAS 363
C+P SH E G C P F C CE + G C + DAC+ +PC+ +
Sbjct: 692 CLP-PSHPCAHEPCSHGICYDAPGG--FRCVCEPGWSGPRCSQSLARDACESQPCRAGGT 748
Query: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF-TCQCPEGY 422
C DG F C C PG G C+ + C +PC +G C S+ C CP+G+
Sbjct: 749 C-----SSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGW 802
Query: 423 FGSACEEKVDPCAS-SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG- 480
G C++ VD CA +PC +G C F+C C G+TGP+C Q I+ C +PC +G
Sbjct: 803 QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862
Query: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540
+C+ S+ C C PG+ G C + +ECLS PC TC D V + C C Y G HC
Sbjct: 863 SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHC 921
Query: 541 ELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQ 599
E C+ SC NG TC DG+N +C+C PG+TG C + + C S PC HGG C
Sbjct: 922 EQDLPDCSPSSCFNGGTC-VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
Query: 600 PNGYNCHCPHGWVGANCEIHLQWKS 624
G+ C C + G C+ + W S
Sbjct: 981 HPGFRCTCLESFTGPQCQTLVDWCS 1005
Score = 219 bits (557), Expect = 9e-57
Identities = 115/306 (37%), Positives = 150/306 (49%), Gaps = 9/306 (2%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C+ G+CT PS +C C +VG C+ D C PC C ++ + F+C
Sbjct: 49 CANGGRCTQLPSREA-ACLCPPGWVGERCQLEDPCHSGPCAGRGVC-QSSVVAGTARFSC 106
Query: 379 VCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPC-AS 436
C G+ G C S D C+ PC +GA C G F C CP GY G +C VD C
Sbjct: 107 RCPRGFRGPDC-SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165
Query: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGT-SYKCLCD 494
PC++ GTC F C C G+TGP C CA SPC +G TCR G +Y C C
Sbjct: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV--SC 552
PG+ G CE ++C CLN TC D VN Y C C E+ G C D C +C
Sbjct: 226 PGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNAC 285
Query: 553 LNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
NG TC + +C+C G+TGE C +I++C + C HG +C D+ + C CP G
Sbjct: 286 HNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKT 345
Query: 613 GANCEI 618
G C +
Sbjct: 346 GLLCHL 351
Score = 216 bits (550), Expect = 6e-56
Identities = 123/394 (31%), Positives = 166/394 (42%), Gaps = 93/394 (23%)
Query: 305 STCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNAS 363
STC C KC +P + C C E + GT C+ D C PC ++
Sbjct: 502 STCQLDVDECASTPCRNGAKCVDQPDG--YECRCAEGFEGTLCDRNVDDCSPDPC-HHGR 558
Query: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
C+D ++F+C C PGYTG C+S++D C PCR+G C+ + + C+CP G
Sbjct: 559 CVDGI-----ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTT 613
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPC----- 477
G CE +D CAS+PC G C DG++ + C C PGFTGP C I+ CA SPC
Sbjct: 614 GVNCEVNIDDCASNPC-TFGVCR-DGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGS 671
Query: 478 ---------------------------------AHGTCRSVGTSYKCLCDPGYHGLYCEE 504
+HG C ++C+C+PG+ G C +
Sbjct: 672 CVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQ 731
Query: 505 EY--NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDS-- 560
+ C S PC TC G+ C C +G CEL PC C +G C+S
Sbjct: 732 SLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL-SPCTPNPCEHGGRCESAP 790
Query: 561 ---------DGLNG-----------------------------TCICAPGFTGEECDIDI 582
G G +C C G+TG CD DI
Sbjct: 791 GQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Query: 583 NECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
N+CD NPC +GGSC D ++C C G+ G C
Sbjct: 851 NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
Score = 208 bits (529), Expect = 2e-53
Identities = 116/358 (32%), Positives = 153/358 (42%), Gaps = 64/358 (17%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DACQRKPCQNNASCIDANE-------- 369
C G C+ + F CTC E + G C+ D C R+PCQN C+
Sbjct: 971 CLHGGVCSA--AHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGW 1028
Query: 370 ----------------------------------KQDGSNFTCVCLPGYTGELCQSKIDY 395
+D S++ CVC G TG C+ ++D
Sbjct: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY-CVCPEGRTGSHCEQEVDP 1087
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCN 455
C+ PC++G TC + G+ C+C GY G CE+ VD CAS PCQ+ G+C + C+
Sbjct: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
Query: 456 CSPGFTGPTCAQLIDFCALSP-------CAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYN 507
C PG G C D C P C H GTC + ++C C PGY GL CE + N
Sbjct: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADIN 1207
Query: 508 ECLSAPCLNAATCRDLV----NGYECVCLAEYKGTHCELYKDPCANVSCLNGATC----- 558
EC S C +AA RD + G+ C+C A + G C+ PC + C +G C
Sbjct: 1208 ECRSGAC-HAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPG 1266
Query: 559 DSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
GL TC CA F G C+ C C G C P G C CP G G +C
Sbjct: 1267 PGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324
Score = 154 bits (389), Expect = 3e-37
Identities = 104/373 (27%), Positives = 139/373 (37%), Gaps = 81/373 (21%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C G+C + S + C C E G+ CE E D C +PCQ+ +C + +
Sbjct: 1055 CQAGGQCVDEDS--SHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC-----RGYMGGYM 1107
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
C CLPGY G+ C+ +D C PC++G +CI ++ + C CP G G CE D C
Sbjct: 1108 CECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG 1167
Query: 438 P-------CQNNGTCYVD------------------------------------------ 448
P C +NGTC VD
Sbjct: 1168 PPLDSGPRCLHNGTC-VDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDP 1226
Query: 449 GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSV-----GTSYKCLCDPGYHGLYC 502
G F C C GF+GP C ++ C PC HG CR G ++ C C + G C
Sbjct: 1227 GGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRC 1286
Query: 503 EEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELY--------KDPCANVSCLN 554
E C C C+ G C C G C + CA CL+
Sbjct: 1287 ERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLH 1346
Query: 555 GATCDSDGLNG--TCICAPGFTGEECDID--INECDSNPCHHGGSCL----DQPNGYNCH 606
G +C L C CA G+TG C+ E P +C DQ C+
Sbjct: 1347 GGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECN 1406
Query: 607 CPH-GWVGANCEI 618
P GW G +C +
Sbjct: 1407 SPGCGWDGGDCSL 1419
Score = 115 bits (287), Expect = 2e-25
Identities = 72/204 (35%), Positives = 98/204 (48%), Gaps = 12/204 (5%)
Query: 433 PCAS-SPCQNNGTC-YVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCA-HGTCRS---VG 486
PC SPC N G C + C C PG+ G C QL D C PCA G C+S G
Sbjct: 42 PCLDGSPCANGGRCTQLPSREAACLCPPGWVGERC-QLEDPCHSGPCAGRGVCQSSVVAG 100
Query: 487 TS-YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCLAEYKGTHCELYK 544
T+ + C C G+ G C + CLS+PC + A C +G + C C Y+G C
Sbjct: 101 TARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDV 159
Query: 545 DPC-ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPN-G 602
D C C +G TC + + C C G+TG C+ C +PC +GG+C +
Sbjct: 160 DECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT 219
Query: 603 YNCHCPHGWVGANCEIHLQWKSGH 626
Y+C C G+ G NCE+++ GH
Sbjct: 220 YDCACLPGFEGQNCEVNVDDCPGH 243
Score = 80.9 bits (198), Expect = 4e-15
Identities = 38/87 (43%), Positives = 47/87 (54%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGGVC R G+SCTCP+G SG+ CQL D CAS PC +G
Sbjct: 473 CQSSPCVNGGVCKDRVN------------GFSCTCPSGFSGSTCQLDVDECASTPCRNG- 519
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ DGY C C EG+EG C++
Sbjct: 520 --AKCVDQPDGYECRCAEGFEGTLCDR 544
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/161 (36%), Positives = 66/161 (40%), Gaps = 49/161 (30%)
Query: 4 RRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCA-AQPCRNGGVCTSR 62
RR +P P AL LLLL AGP AAP PC PC NGG CT
Sbjct: 12 RRPMSPPPPPPPVRALPLLLLLAGPGA--------AAP-----PCLDGSPCANGGRCTQL 58
Query: 63 PE------------------PDPQHPAP------------AGEPGYSCTCPAGISGANCQ 92
P DP H P AG +SC CP G G +C
Sbjct: 59 PSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS 118
Query: 93 LVADPCASNPCHHGNCSSSSSSSSDG-YLCICNEGYEGPNC 132
L DPC S+PC HG + S DG +LC C GY+G +C
Sbjct: 119 L-PDPCLSSPCAHG---ARCSVGPDGRFLCSCPPGYQGRSC 155
Score = 73.2 bits (178), Expect = 8e-13
Identities = 34/88 (38%), Positives = 47/88 (53%), Gaps = 17/88 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-G 106
C +QPCR GG C+S G+ CTCP G+ G C+L++ PC NPC H G
Sbjct: 738 CESQPCRAGGTCSS------------DGMGFHCTCPPGVQGRQCELLS-PCTPNPCEHGG 784
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C S+ +C C +G++GP C+Q
Sbjct: 785 RCESAPGQLP---VCSCPQGWQGPRCQQ 809
Score = 72.4 bits (176), Expect = 1e-12
Identities = 33/86 (38%), Positives = 39/86 (45%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PCRNG C +P+ GY C C G G C D C+ +PCHHG
Sbjct: 511 CASTPCRNGAKCVDQPD------------GYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
C +S S C C GY G CE
Sbjct: 559 CVDGIASFS----CACAPGYTGTRCE 580
Score = 69.7 bits (169), Expect = 9e-12
Identities = 32/85 (37%), Positives = 42/85 (49%), Gaps = 16/85 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +QPCR+GG C + Y C CP+G +G NC++ D CASNPC G
Sbjct: 586 CRSQPCRHGGKCLDLVDK------------YLCRCPSGTTGVNCEVNIDDCASNPCTFGV 633
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
C + Y C+C G+ GP C
Sbjct: 634 CRDGINR----YDCVCQPGFTGPLC 654
Score = 68.6 bits (166), Expect = 2e-11
Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 16/89 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC GG C GE G+ C CP G C + PCA PC HG
Sbjct: 661 CASSPCGEGGSCVD------------GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI 708
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
C + G+ C+C G+ GP C Q+L
Sbjct: 709 CYDAPG----GFRCVCEPGWSGPRCSQSL 733
Score = 67.4 bits (163), Expect = 5e-11
Identities = 32/86 (37%), Positives = 41/86 (47%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ C NGG C G +SC C G +GA+CQ ADPC S PC HG
Sbjct: 928 CSPSSCFNGGTCVD------------GVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGG 975
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S++ G+ C C E + GP C+
Sbjct: 976 V---CSAAHPGFRCTCLESFTGPQCQ 998
Score = 65.5 bits (158), Expect = 2e-10
Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSS 110
+PCR+GG C + P + C CPAG +G C+ A PCA +PC +G
Sbjct: 166 EPCRHGGTCLNTPG------------SFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCR 213
Query: 111 SSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
S + Y C C G+EG NCE + P
Sbjct: 214 QSGDLT--YDCACLPGFEGQNCEVNVDDCP 241
Score = 64.7 bits (156), Expect = 3e-10
Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 16/90 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG C G +SC+C G +G C D C SNPC G
Sbjct: 853 CDPNPCLNGGSCQD------------GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT 900
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
C+ +S + C C GY G +CEQ LP
Sbjct: 901 CTDHVAS----FTCTCPPGYGGFHCEQDLP 926
Score = 63.5 bits (153), Expect = 7e-10
Identities = 35/90 (38%), Positives = 43/90 (47%), Gaps = 17/90 (18%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN-PCH- 104
PC PC +GG C S P P C+CP G G CQ D CA PC
Sbjct: 774 PCTPNPCEHGGRCESAPGQLPV-----------CSCPQGWQGPRCQQDVDECAGPAPCGP 822
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
HG C++ + S S C C+ GY GP+C+Q
Sbjct: 823 HGICTNLAGSFS----CTCHGGYTGPSCDQ 848
Score = 62.8 bits (151), Expect = 1e-09
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 37/120 (30%)
Query: 48 CAAQPCRNGG------------------VCTSRPEPDPQHPAPAG--------------- 74
C+ QPC+NGG +C R P + A G
Sbjct: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
Query: 75 -EPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+ + C CP G +G++C+ DPC + PC HG + GY+C C GY G NCE
Sbjct: 1064 EDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHG---GTCRGYMGGYMCECLPGYNGDNCE 1120
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/101 (32%), Positives = 46/101 (45%), Gaps = 16/101 (15%)
Query: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC-ASN 101
S P PC + PC +G C+ P+ + C+CP G G +C+ D C
Sbjct: 118 SLPDPCLSSPCAHGARCSVGPDGR-----------FLCSCPPGYQGRSCRSDVDECRVGE 166
Query: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ-ALPSLPA 141
PC HG ++ S + C C GY GP CE A+P P+
Sbjct: 167 PCRHGGTCLNTPGS---FRCQCPAGYTGPLCENPAVPCAPS 204
Score = 62.0 bits (149), Expect = 2e-09
Identities = 34/87 (39%), Positives = 38/87 (43%), Gaps = 15/87 (17%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PC AQPC++GG C GY C C G +G NC+ D CAS PC HG
Sbjct: 1087 PCLAQPCQHGGTCRGYMG------------GYMCECLPGYNGDNCEDDVDECASQPCQHG 1134
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
S YLC C G G CE
Sbjct: 1135 ---GSCIDLVARYLCSCPPGTLGVLCE 1158
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 19/94 (20%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PC ++PC +GGVC+ A PG+ CTC +G CQ + D C+ PC +G
Sbjct: 965 PCLSRPCLHGGVCS------------AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNG 1012
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
G C+C G+ G C+ + SLP
Sbjct: 1013 -----GRCVQTGAYCLCPPGWSGRLCD--IRSLP 1039
Score = 61.2 bits (147), Expect = 3e-09
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 33/122 (27%)
Query: 48 CAAQPCRNGGVCT---------------------SRPEPDPQHPAPAGEP---------- 76
CA+QPC++GG C + + P P +G
Sbjct: 1126 CASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDL 1185
Query: 77 --GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
G+ CTCP G +G C+ + C S CH + G+ C+C+ G+ GP C+
Sbjct: 1186 VGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQT 1245
Query: 135 AL 136
L
Sbjct: 1246 VL 1247
Score = 59.7 bits (143), Expect = 9e-09
Identities = 30/89 (33%), Positives = 39/89 (43%), Gaps = 17/89 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCA--SNPCHH 105
C + PC +C + P CTCP G +G C D C+ +NPC H
Sbjct: 355 CVSNPCHEDAICDTNPVNGRA----------ICTCPPGFTGGACDQDVDECSIGANPCEH 404
Query: 106 -GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G C ++ S +LC C GY GP CE
Sbjct: 405 LGRCVNTQGS----FLCQCGRGYTGPRCE 429
Score = 59.7 bits (143), Expect = 9e-09
Identities = 31/88 (35%), Positives = 38/88 (43%), Gaps = 6/88 (6%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSS 112
CR+G + Q P G+ C C AG SG CQ V PC S PC HG S
Sbjct: 1209 CRSGACHAAHTRDCLQDPGG----GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPS 1264
Query: 113 SSSSDG--YLCICNEGYEGPNCEQALPS 138
G + C C + + GP CE+ S
Sbjct: 1265 PGPGGGLTFTCHCAQPFWGPRCERVARS 1292
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/112 (33%), Positives = 44/112 (39%), Gaps = 20/112 (17%)
Query: 33 LANPVPAAPLSAPG--PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN 90
L P PL P PCA +PC +G +C P G+ C C G SG
Sbjct: 682 LCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPG------------GFRCVCEPGWSGPR 728
Query: 91 CQ--LVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
C L D C S PC G SS G+ C C G +G CE P P
Sbjct: 729 CSQSLARDACESQPCRAGGTCSSDGM---GFHCTCPPGVQGRQCELLSPCTP 777
Score = 56.6 bits (135), Expect = 8e-08
Identities = 37/128 (28%), Positives = 50/128 (39%), Gaps = 44/128 (34%)
Query: 47 PCAAQPCRNGGVCTSRPEPDP---------------------------QHPAPAGEP--- 76
PC +QPC++GG C RP P P + P G P
Sbjct: 1249 PCESQPCQHGGQC--RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQ 1306
Query: 77 ---GYSCTCPAGISGANCQLVAD--------PCASNPCHHGNCSSSSSSSSDGYLCICNE 125
G C CP G+SG +C+ CA+ PC HG S + + + C C +
Sbjct: 1307 TPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG-SCRPAPLAPFFRCACAQ 1365
Query: 126 GYEGPNCE 133
G+ GP CE
Sbjct: 1366 GWTGPRCE 1373
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/109 (31%), Positives = 42/109 (38%), Gaps = 26/109 (23%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PCA PCRNGG C +G+ Y C C G G NC++ D C + C +G
Sbjct: 200 PCAPSPCRNGGTCRQ-----------SGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNG 248
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQP 155
C +G NC Q P TE + QLQP
Sbjct: 249 G--------------TCVDGVNTYNC-QCPPEWTGQFCTEDVDECQLQP 282
Score = 53.5 bits (127), Expect = 7e-07
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PCRN C R G+ ++C C AG +G C++ D C S+PC +G
Sbjct: 435 CLSGPCRNQATCLDR----------IGQ--FTCICMAGFTGTYCEVDIDECQSSPCVNGG 482
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+G+ C C G+ G C+
Sbjct: 483 V---CKDRVNGFSCTCPSGFSGSTCQ 505
Score = 47.0 bits (110), Expect = 6e-05
Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA C +G C R + C CP G +G C L D C SNPCH +
Sbjct: 318 CATAVCFHGATCHDRVA------------SFYCACPMGKTGLLCHL-DDACVSNPCHE-D 363
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
++ + +C C G+ G C+Q
Sbjct: 364 AICDTNPVNGRAICTCPPGFTGGACDQ 390
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 19/88 (21%)
Query: 48 CAAQP--CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105
C QP C NGG C + G+SC C G +G +C D CA+ C H
Sbjct: 278 CQLQPNACHNGGTCFNTLG------------GHSCVCVNGWTGESCSQNIDDCATAVCFH 325
Query: 106 G-NCSSSSSSSSDGYLCICNEGYEGPNC 132
G C +S + C C G G C
Sbjct: 326 GATCHDRVAS----FYCACPMGKTGLLC 349
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/101 (23%), Positives = 36/101 (35%), Gaps = 11/101 (10%)
Query: 41 PLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPG--------YSCTCPAGISGANCQ 92
P++ C P GG C + P G + C C G +G C+
Sbjct: 370 PVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Query: 93 LVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+ C S PC + ++ + CIC G+ G CE
Sbjct: 430 TDVNECLSGPCRN---QATCLDRIGQFTCICMAGFTGTYCE 467
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 7/62 (11%)
Query: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYN-CHCPHGWVGANCEIHLQWKSGH 626
+ PG C D +PC +GG C P+ C CP GWVG C++ SG
Sbjct: 33 LAGPGAAAPPC------LDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP 86
Query: 627 MA 628
A
Sbjct: 87 CA 88
Score = 38.1 bits (87), Expect = 0.030
Identities = 47/178 (26%), Positives = 61/178 (34%), Gaps = 42/178 (23%)
Query: 309 PGESHAN--DLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE---------EYDACQRKP 357
PG S+A+ C G C P F C C + + G CE E C R
Sbjct: 1332 PGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAA 1391
Query: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
CQ A D ++ ++ C G+ G C + DP R Q
Sbjct: 1392 CQ--AKRGDQRCDRECNSPGC----GWDGGDCSLSVG----DPWRQCE---------ALQ 1432
Query: 418 CPEGYFGSACEEKVDPCASSPC--QNNGTCYVDGVHFTCN------CSPGFTGPTCAQ 467
C + S C DP SSP +N C+ G TCN C+ F C Q
Sbjct: 1433 CWRLFNNSRC----DPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQ 1486
Score = 37.0 bits (84), Expect = 0.066
Identities = 36/122 (29%), Positives = 47/122 (38%), Gaps = 29/122 (23%)
Query: 28 PRGSSLANPVPAA-------PLSAPGP----CAAQPCRNGGVCTSRPEPDPQHPAPAGEP 76
PRG A P + P S PG CAA PC +GG C PAP P
Sbjct: 1308 PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSC---------RPAPLA-P 1357
Query: 77 GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDG-YLC--ICNE---GYEGP 130
+ C C G +G C+ A A C ++ + G C CN G++G
Sbjct: 1358 FFRCACAQGWTGPRCE--APAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGG 1415
Query: 131 NC 132
+C
Sbjct: 1416 DC 1417
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 259 bits (663), Expect = 5e-69
Identities = 120/313 (38%), Positives = 163/313 (52%), Gaps = 16/313 (5%)
Query: 317 LECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSN 375
L C G C + F C C + G+ CE E + C +PC+NN +C+D +
Sbjct: 897 LSCQDYGDCEDMVNN--FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNR----- 949
Query: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
F C C P Y G C+ ++ C + PC + C+ G+ C C GY G CE +D C
Sbjct: 950 FFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECL 1009
Query: 436 SSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCD 494
S PC ++G C +DG+ H+TC+C GF G C + C +PC HG C + Y C CD
Sbjct: 1010 SEPCLHDGVC-IDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCD 1068
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCA-----N 549
C+ + N+C S PC+N C+ +G+ C+C Y G +CE D CA +
Sbjct: 1069 ADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNS 1128
Query: 550 VSCLNGATC-DSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCP 608
V CLNG C D G C C PGF+G+ C+I+INEC S+PC HG C D NGY C C
Sbjct: 1129 VICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQ 1188
Query: 609 HGWVGANCEIHLQ 621
GW G +CE L+
Sbjct: 1189 PGWSGHHCENELE 1201
Score = 229 bits (585), Expect = 5e-60
Identities = 119/337 (35%), Positives = 166/337 (49%), Gaps = 23/337 (6%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQ--RKPCQNNASC---IDANEKQD 372
C G C F C C Y G FC + Y+ C PC+NN++C +DAN+
Sbjct: 818 CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQH-- 875
Query: 373 GSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD 432
C+C + G+ C+ + C+ C++ C ++ F C C G+ GS CE +++
Sbjct: 876 -----CICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEIN 930
Query: 433 PCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCA-HGTCRSVGTSYKC 491
C+S PC+NNGTC F CNC P + GP C ++ C +SPC C Y C
Sbjct: 931 ECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNC 990
Query: 492 LCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVS 551
LC PGY G+ CE +ECLS PCL+ C D +N Y C C + + GTHCE + C +
Sbjct: 991 LCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNP 1050
Query: 552 CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGW 611
CL+G C C C T +C I IN+C S PC + G C +G+ C CP G+
Sbjct: 1051 CLHG-RCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGY 1109
Query: 612 VGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCV 648
GA CE + + AE N S+ + G +CV
Sbjct: 1110 TGAYCEKSID----NCAEPELN----SVICLNGGICV 1138
Score = 186 bits (472), Expect = 7e-47
Identities = 99/300 (33%), Positives = 137/300 (45%), Gaps = 54/300 (18%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C + F C CE +Y G FCE + + C+ PC + +C+ + DG N
Sbjct: 937 CKNNGTCVDLTNR--FFCNCEPEYHGPFCELDVNKCKISPCLDEENCV---YRTDGYN-- 989
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEE-------- 429
C+C PGYTG C+ +D C+ +PC + CI ++ +TC C G+FG+ CE
Sbjct: 990 CLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSN 1049
Query: 430 -----------------------------KVDPCASSPCQNNGTCYVDGVHFTCNCSPGF 460
K++ C S PC N G C FTC C G+
Sbjct: 1050 PCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGY 1109
Query: 461 TGPTCAQLIDFCALSPCAHGTCRSVGT-------SYKCLCDPGYHGLYCEEEYNECLSAP 513
TG C + ID CA C + G ++ C C PG+ G +CE NEC S+P
Sbjct: 1110 TGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSP 1169
Query: 514 CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGF 573
CL+ A C D +NGY C C + G HCE + C SC++ C + TC+C PGF
Sbjct: 1170 CLHGADCEDHINGYVCKCQPGWSGHHCENELE-CIPNSCVH-ELCMENEPGSTCLCTPGF 1227
Score = 181 bits (460), Expect = 2e-45
Identities = 105/348 (30%), Positives = 160/348 (45%), Gaps = 9/348 (2%)
Query: 237 ILLWKVTATGFQQC---SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSI 293
I L V+ T F C + + + + + G + + L++G ++FI + +
Sbjct: 101 INLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP 160
Query: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC 353
+ LRL + VK C ES +++ CSG GKC ++ T+SC C+ + G +C+E DAC
Sbjct: 161 LGLRLNVTVKQQFCQ--ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
Query: 354 QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG 413
KPC+NN SCI+ E D + CVC P +TG+ C I C C +G + +
Sbjct: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
Query: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
F C+C E + G CE PC S G C +T C G + + +
Sbjct: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
Query: 474 LSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532
L PC +GT C + C+C P + L C+ C S P N ATC+ Y C C+
Sbjct: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
Query: 533 AEYKGTHCELYKDPC--ANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
+ + +CE D C +++CLN C + +C PG T C
Sbjct: 398 SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
Score = 176 bits (447), Expect = 5e-44
Identities = 98/317 (30%), Positives = 147/317 (46%), Gaps = 24/317 (7%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGT-FCEEYDACQRKPCQNNASCIDANEKQDGSNFT 377
C+ C ++ + C ++ G + E Q CQ+ A C D +
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRP-----R 589
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRN-GATCISSLSGFTCQCPEGYFGSACEEKVDPCAS 436
C C Y G LC +DYC+ + + C++ C + Y + CE + C S
Sbjct: 590 CSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKS 649
Query: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRS----------- 484
+ C+N T +F C PGF G C ID CA PC +G TC
Sbjct: 650 ASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVP 709
Query: 485 ---VGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
V + CLC+PGY G+ CE++ ++C+ C + +TC+DL Y+CVCL++++G CE
Sbjct: 710 PFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCE 769
Query: 542 LYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQ-- 599
+ C C N +TC + C C G+TG+ C +INECDS+PC +GG C +
Sbjct: 770 QESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTI 829
Query: 600 PNGYNCHCPHGWVGANC 616
P + C CP + G C
Sbjct: 830 PGQFVCLCPPLYTGQFC 846
Score = 122 bits (305), Expect = 2e-27
Identities = 72/235 (30%), Positives = 103/235 (43%), Gaps = 18/235 (7%)
Query: 401 CRNGATCISSLSG--FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSP 458
C NG +C+S + C + G+ E + CQ+ C + C+CS
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSL 594
Query: 459 GFTGPTCAQLIDFCA--LSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLN 516
+ G C +D+C S HG C ++ + C Y CE + +C SA C N
Sbjct: 595 SYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKN 654
Query: 517 AATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC-DSDG------------L 563
T L + C+ +KGT CE+ D CA+ C NGATC D G +
Sbjct: 655 GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVV 714
Query: 564 NG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
+G +C+C PG+ G C+ DI++C N C H +C D Y C C W G CE
Sbjct: 715 DGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCE 769
Score = 119 bits (297), Expect = 1e-26
Identities = 66/225 (29%), Positives = 95/225 (42%), Gaps = 9/225 (4%)
Query: 401 CRNGATCISSL--SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV-----DGVHFT 453
C C+S ++C C + G C+E +D C+ PC+NNG+C D +
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
Query: 454 CNCSPGFTGPTCAQLIDFCALSPCAHGTCRSV-GTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C P FTG C+++I C C HG C ++ S+ C CD + G +CE C+S
Sbjct: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
C + + Y C + E + V C NG C + CIC+P
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
FT C C+S P + +C Y C C G+ NCE
Sbjct: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
Score = 114 bits (285), Expect = 3e-25
Identities = 67/211 (31%), Positives = 101/211 (47%), Gaps = 27/211 (12%)
Query: 311 ESHANDLECSG--KGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDA 367
E++AND + G+CT +E + C+C+ T C+ + + C PC N C
Sbjct: 1040 ETNANDCLSNPCLHGRCTELINE--YPCSCDADGTSTQCKIKINDCTSIPCMNEGFC--- 1094
Query: 368 NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP------CRNGATCISSLSG-FTCQCPE 420
++ FTC+C GYTG C+ ID C +P C NG C+ F C+C
Sbjct: 1095 --QKSAHGFTCICPRGYTGAYCEKSIDNCA-EPELNSVICLNGGICVDGPGHTFDCRCLP 1151
Query: 421 GYFGSACEEKVDPCASSPCQNNGTC--YVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCA 478
G+ G CE ++ C+SSPC + C +++G + C C PG++G C ++ C + C
Sbjct: 1152 GFSGQFCEININECSSSPCLHGADCEDHING--YVCKCQPGWSGHHCENELE-CIPNSCV 1208
Query: 479 HGTCRSVGTSYKCLCDPGYH----GLYCEEE 505
H C CLC PG+ GL C +E
Sbjct: 1209 HELCMENEPGSTCLCTPGFMTCSIGLLCGDE 1239
Score = 97.8 bits (242), Expect = 3e-20
Identities = 87/373 (23%), Positives = 133/373 (35%), Gaps = 61/373 (16%)
Query: 323 GKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLP 382
G C+ S + F C C+EQ+ G FCE KPC + S +T C
Sbjct: 268 GNCSNITSNS-FICECDEQFSGPFCE----VSAKPCVSLLFWKRGICPNSSSAYTYECPK 322
Query: 383 GYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNN 442
G + + ++ + L PC+NG CI + C C + C+ C S P +NN
Sbjct: 323 GSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNN 382
Query: 443 GTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-----------------------CAH 479
TC + C+C GFT C + ID C L C
Sbjct: 383 ATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTK 442
Query: 480 GTCRSVGTSYK-----CLCDPGYHGLYCEE------EYNECLSAPCLNAATCRDLVNGYE 528
C + Y C C +HG+ C++ EY L C+ +++ Y
Sbjct: 443 NPCWFLKNVYLIHQHLCYCGVTFHGI-CQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAY- 500
Query: 529 CVCLAEYKGTHCELYKDPCANVS------------CLNGATC--DSDGLNGTCICAPGFT 574
LA DP N S C NG +C + D +C +
Sbjct: 501 -FFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWA 559
Query: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNM 634
G + + N C H C D+ N C C ++G C +++ + G+ + S+
Sbjct: 560 GNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISV--- 616
Query: 635 PRHSLYIIIGALC 647
H L + + C
Sbjct: 617 --HGLCLALSHNC 627
Score = 77.0 bits (188), Expect = 6e-14
Identities = 83/351 (23%), Positives = 122/351 (34%), Gaps = 78/351 (22%)
Query: 336 CTCEEQYVGTFCEEYD-ACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKID 394
C C + C+ +C+ P +NNA+C K+ ++ C C+ G+T + C+ ID
Sbjct: 356 CICSPIFTDLLCKSIQTSCESFPLRNNATC-----KKCEKDYPCSCISGFTEKNCEKAID 410
Query: 395 YCILDP--CRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQ--------NNGT 444
+C L C N C + + F C G C +PC +
Sbjct: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPG------------CTKNPCWFLKNVYLIHQHL 458
Query: 445 CYVDGVHFTCNCSP---------------GFTGPTCAQLID---FCALSP---------- 476
CY GV F C G G C +ID F A +
Sbjct: 459 CYC-GVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP 517
Query: 477 -----------------CAHG-TCRSVGTS--YKCLCDPGYHGLYCEEEYNECLSAPCLN 516
CA+G +C S S Y+ LC + G E + C +
Sbjct: 518 EDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQH 577
Query: 517 AATCRDLVNGYECVCLAEYKGTHCELYKDPC-ANVSCLNGATCDSDGLNGTCICAPGFTG 575
A C+D +N C C Y G C + D C N S C + N C +
Sbjct: 578 EAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYER 637
Query: 576 EECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGH 626
C+ID +C S C +G + + C G+ G CEI + + H
Sbjct: 638 NICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH 688
Score = 70.5 bits (171), Expect = 5e-12
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ +PC+N G C ++ E E Y C C +G NC + C + C HGN
Sbjct: 217 CSFKPCKNNGSCINKREN-------WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE-QALPSLPATGWTESMAP 150
CS+ +S+S ++C C+E + GP CE A P + W + P
Sbjct: 270 CSNITSNS---FICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
Score = 67.4 bits (163), Expect = 5e-11
Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 541 ELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECD--SNPCHH---GGS 595
+ + PC+ + C NG TC G + C C G+ G C ++ CD +P HH G +
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 596 CLDQPNGYNCHCPHGWVGANCE 617
C+ P+GY C CP G G CE
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCE 2689
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/163 (26%), Positives = 62/163 (38%), Gaps = 24/163 (14%)
Query: 475 SPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAE 534
SPC G +V T + C +C CL+ A + Y C C
Sbjct: 157 SPCPLGLRLNV-TVKQQFCQESLSSEFCSGH------GKCLSEAWSKT----YSCHCQPP 205
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGT-----CICAPGFTGEECDIDINECDSNP 589
+ G +C+ D C+ C N +C + N C+C P FTG+ C I +C +
Sbjct: 206 FSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV 264
Query: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCEIH-------LQWKSG 625
C HG N + C C + G CE+ L WK G
Sbjct: 265 CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/146 (28%), Positives = 59/146 (40%), Gaps = 18/146 (12%)
Query: 433 PCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFC-----ALSPCAHG-TCRSVG 486
PC+ C N GTC G CNC+ G+ G C + + C C+ G TC S+
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP 2672
Query: 487 TSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEY---KGTHCELY 543
Y C C G G+YCE+ + +S P + N + A + K TH +L
Sbjct: 2673 HGYTCFCPLGTTGIYCEQALS--ISDPSFRS-------NELSWMSFASFHVRKKTHIQLQ 2723
Query: 544 KDPCANVSCLNGATCDSDGLNGTCIC 569
P A L A +G +C
Sbjct: 2724 FQPLAADGILFYAAQHLKAQSGDFLC 2749
Score = 59.7 bits (143), Expect = 9e-09
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 14/88 (15%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSS 112
C NGG+C P + C C G SG C++ + C+S+PC HG +
Sbjct: 1131 CLNGGICVDGPGHT-----------FDCRCLPGFSGQFCEININECSSSPCLHG---ADC 1176
Query: 113 SSSSDGYLCICNEGYEGPNCEQALPSLP 140
+GY+C C G+ G +CE L +P
Sbjct: 1177 EDHINGYVCKCQPGWSGHHCENELECIP 1204
Score = 59.7 bits (143), Expect = 9e-09
Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCY-VDGVH 451
+ +C CRN TCIS C+CP Y G C+ C ++PC N TC G
Sbjct: 2336 VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTD 2393
Query: 452 FTCNCSPGFTGPTCAQLID 470
C C G +GP C I+
Sbjct: 2394 IVCLCPYGRSGPLCTDAIN 2412
Score = 59.3 bits (142), Expect = 1e-08
Identities = 28/74 (37%), Positives = 38/74 (51%), Gaps = 3/74 (4%)
Query: 434 CASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT--CRSVGTSYKC 491
C + C+N G C V+G F+C C P + G TC Q + C + C H + SY C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 492 LCDPGYHGLYCEEE 505
LC G+ G YCE +
Sbjct: 2938 LCTLGWVGRYCENK 2951
Score = 58.5 bits (140), Expect = 2e-08
Identities = 27/72 (37%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Query: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCL-DQPNGYNC 605
C +C NG C +G +C C P + G C+ ++ C +N C H C+ DQ Y+C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 606 HCPHGWVGANCE 617
C GWVG CE
Sbjct: 2938 LCTLGWVGRYCE 2949
Score = 58.2 bits (139), Expect = 3e-08
Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 5/89 (5%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGE--PGYSCTCPAGISGANCQLVADPCASNPCHH 105
CA+ PC+NG C +P P + G+SC C G G C+ D C N C H
Sbjct: 685 CASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEH 744
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+S+ Y C+C +EG CEQ
Sbjct: 745 ---NSTCKDLHLSYQCVCLSDWEGNFCEQ 770
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 31/113 (27%)
Query: 48 CAAQPCRNGGVCTSRPEP-----DPQHPAPAGE---------------------PGYSCT 81
C+++PC+N G C +P++ P E GY+C
Sbjct: 932 CSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCL 991
Query: 82 CPAGISGANCQLVADPCASNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
C G +G NC++ D C S PC H G C + Y C C G+ G +CE
Sbjct: 992 CAPGYTGINCEINLDECLSEPCLHDGVCIDGINH----YTCDCKSGFFGTHCE 1040
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 8/81 (9%)
Query: 353 CQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCI-SSL 411
C C+NN +CI NE N C C Y+G+LCQ C +PC NGATC+ S
Sbjct: 2339 CAHHLCRNNGTCISDNE-----NLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSG 2391
Query: 412 SGFTCQCPEGYFGSACEEKVD 432
+ C CP G G C + ++
Sbjct: 2392 TDIVCLCPYGRSGPLCTDAIN 2412
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/123 (26%), Positives = 46/123 (37%), Gaps = 46/123 (37%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C ++PC + GVC G Y+C C +G G +C+ A+ C SNPC HG
Sbjct: 1008 CLSEPCLHDGVCID------------GINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR 1055
Query: 108 CS----------------------------------SSSSSSSDGYLCICNEGYEGPNCE 133
C+ S+ G+ CIC GY G CE
Sbjct: 1056 CTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCE 1115
Query: 134 QAL 136
+++
Sbjct: 1116 KSI 1118
Score = 54.3 bits (129), Expect = 4e-07
Identities = 78/377 (20%), Positives = 137/377 (36%), Gaps = 63/377 (16%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCH 104
PC+ C NGG C +G Y C C G G+ C C +P H
Sbjct: 2613 PCSLMKCGNGGTCIE-----------SGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPH 2660
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDK 164
H + ++ S GY C C G G CEQAL + + ++
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHV------ 2714
Query: 165 ILPRSQATVTLPTWQPKTGQKVVEMKWDQVEV-IPDIACGNASSNS-----SAGGRLVSF 218
R + + L +QP ++ ++ D C + ++S + G R +
Sbjct: 2715 ---RKKTHIQL-QFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIIL 2770
Query: 219 EVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQAS-------------G 265
E Q ++ +T +I +V A G+ +DG +VT ++ G
Sbjct: 2771 ETLQKVTI---NGSTWHIIKAGRVGAEGYLD---LDGINVTEKASTKMSSLDTNTDFYIG 2824
Query: 266 GLVLLEEMLALG-NNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGK 324
G+ L + + N +GF + ++ L + G S+ D + + G
Sbjct: 2825 GVSSLNLVNPMAIENEPVGF--QGCIRQVIINNQELQL-TEFGAKGGSNVGDCDGTACGY 2881
Query: 325 CTTK-PSEATFSCT-----CEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
T + E T + T C + G C + +C C + + CI +++C
Sbjct: 2882 NTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCI----PDQSFSYSC 2937
Query: 379 VCLPGYTGELCQSKIDY 395
+C G+ G C++K +
Sbjct: 2938 LCTLGWVGRYCENKTSF 2954
Score = 53.5 bits (127), Expect = 7e-07
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 10/103 (9%)
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVD-GVHFTC 454
C + CRNG C + + F+C+C + G+ C + V C ++ C + C D ++C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 455 NCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497
C+ G+ G C F T + +G SY DP Y
Sbjct: 2938 LCTLGWVGRYCENKTSF--------STAKFMGNSYIKYIDPNY 2972
Score = 53.1 bits (126), Expect = 9e-07
Identities = 29/79 (36%), Positives = 33/79 (41%), Gaps = 5/79 (6%)
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC-----ASSPCQNNGTCYVDGV 450
C L C NG TCI S + C C G+ GS C E V C C TC
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 451 HFTCNCSPGFTGPTCAQLI 469
+TC C G TG C Q +
Sbjct: 2674 GYTCFCPLGTTGIYCEQAL 2692
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 7/98 (7%)
Query: 352 ACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL 411
AC C+N C +G+ F+C CLP + G C + C+ + C + + CI
Sbjct: 2878 ACGYNTCRNGGECT-----VNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQ 2931
Query: 412 S-GFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVD 448
S ++C C G+ G CE K + N+ Y+D
Sbjct: 2932 SFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYID 2969
Score = 50.8 bits (120), Expect = 4e-06
Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 434 CASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TC-RSVGTSYKC 491
CA C+NNGTC D + C C ++G C C +PC +G TC GT C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396
Query: 492 LCDPGYHGLYCEEEYN 507
LC G G C + N
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 50.1 bits (118), Expect = 8e-06
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 13/87 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC+N CT + Y C C +G +G NC + C S+PC +G
Sbjct: 775 CKMNPCKNNSTCTDLYK------------SYRCECTSGWTGQNCSEEINECDSDPCMNGG 822
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
S+ ++C+C Y G C Q
Sbjct: 823 LCHESTIPGQ-FVCLCPPLYTGQFCHQ 848
Score = 50.1 bits (118), Expect = 8e-06
Identities = 30/89 (33%), Positives = 37/89 (41%), Gaps = 16/89 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA CRN G C S E C CP SG CQ + C +NPC GN
Sbjct: 2339 CAHHLCRNNGTCISDNE------------NLFCECPRLYSGKLCQFAS--CENNPC--GN 2382
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
++ S +C+C G GP C A+
Sbjct: 2383 GATCVPKSGTDIVCLCPYGRSGPLCTDAI 2411
Score = 50.1 bits (118), Expect = 8e-06
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP-NGYNC 605
CA+ C N TC SD N C C ++G+ C C++NPC +G +C+ + C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVC 2396
Query: 606 HCPHGWVGANC 616
CP+G G C
Sbjct: 2397 LCPYGRSGPLC 2407
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 11/64 (17%)
Query: 82 CPAGISGANCQLVADPCASNPCHHG-NCSSSSSS----------SSDGYLCICNEGYEGP 130
C G G C++ D CAS+PC +G C + DG+ C+CN GY G
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGI 728
Query: 131 NCEQ 134
CEQ
Sbjct: 729 RCEQ 732
Score = 47.4 bits (111), Expect = 5e-05
Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 7/76 (9%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C G C + +E F C C Y G C+ + +C+ PC N A+C+ + G++ C
Sbjct: 2344 CRNNGTCISD-NENLF-CECPRLYSGKLCQ-FASCENNPCGNGATCV----PKSGTDIVC 2396
Query: 379 VCLPGYTGELCQSKID 394
+C G +G LC I+
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 14/88 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCHH 105
C + PC NGG+C P + C CP +G C + C NPC
Sbjct: 813 CDSDPCMNGGLCHESTIPGQ----------FVCLCPPLYTGQFCHQRYNLCDLLHNPCR- 861
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
N S+ + CIC E +EG NCE
Sbjct: 862 -NNSTCLALVDANQHCICREEFEGKNCE 888
Score = 44.3 bits (103), Expect = 4e-04
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+ C C G SG+ C++ + C+S PC ++G C ++ + C C Y GP CE
Sbjct: 912 FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNR----FFCNCEPEYHGPFCE 964
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSS-SSDGYLCICNEGYEGPNCEQA 135
YSC C SG CQ + D C+ PC ++G+C + + Y C+C+ + G NC +
Sbjct: 198 YSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Query: 136 L 136
+
Sbjct: 257 I 257
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 9/73 (12%)
Query: 469 IDFCALSPCAHGTCRSVGTSYK------CLCDPGYHGLYCEEEYNECLSAPCLNAATCRD 522
I+ C + CAH CR+ GT C C Y G C ++ C + PC N ATC
Sbjct: 2331 IENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVP 2388
Query: 523 LVNGYECVCLAEY 535
+G + VCL Y
Sbjct: 2389 -KSGTDIVCLCPY 2400
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/76 (34%), Positives = 30/76 (39%), Gaps = 3/76 (3%)
Query: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC-DSDGLNGTC 567
C C N TC C C Y G C+ C N C NGATC G + C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKSGTDIVC 2396
Query: 568 ICAPGFTGEECDIDIN 583
+C G +G C IN
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 16/83 (19%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HGNCSS 110
PCRN C + + + QH C C G NC++ C C +G+C
Sbjct: 859 PCRNNSTCLALVDAN-QH----------CICREEFEGKNCEIDVKDCLFLSCQDYGDCED 907
Query: 111 SSSSSSDGYLCICNEGYEGPNCE 133
++ + CIC G+ G CE
Sbjct: 908 MVNN----FRCICRPGFSGSLCE 926
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 6/69 (8%)
Query: 514 CLNAATCRDLVNG--YECVCLAEYKGTHCELYKDPCANVSCLNGATCDSD-GLNGTCICA 570
C N C VNG + C CL ++ G C C N CL+ + C D + +C+C
Sbjct: 2884 CRNGGECT--VNGTTFSCRCLPDWAGNTCN-QSVSCLNNLCLHQSLCIPDQSFSYSCLCT 2940
Query: 571 PGFTGEECD 579
G+ G C+
Sbjct: 2941 LGWVGRYCE 2949
Score = 36.6 bits (83), Expect = 0.086
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 18/100 (18%)
Query: 310 GESHAND---LECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKP-----CQN 360
G+ HA+ ++C G C S + C C + G+FC E C + C
Sbjct: 2607 GQCHASPCSLMKCGNGGTCIE--SGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSR 2664
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP 400
A+CI +TC C G TG C+ + I DP
Sbjct: 2665 GATCISLPH-----GYTCFCPLGTTGIYCEQALS--ISDP 2697
Score = 35.4 bits (80), Expect = 0.19
Identities = 13/38 (34%), Positives = 16/38 (42%)
Query: 579 DIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
D D C N C +GG C ++C C W G C
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC 2910
Score = 33.1 bits (74), Expect = 0.95
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 14/75 (18%)
Query: 362 ASCIDANEKQDGSN--FTCVCLPGYTGELCQSKIDYCILDPCRNGATC-----ISSLSGF 414
AS +DA++ G + +T V +CQ D C NG TC S + F
Sbjct: 2074 ASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQ-------DVCHNGGTCHAIFLSSGIVSF 2126
Query: 415 TCQCPEGYFGSACEE 429
C CP + G CE+
Sbjct: 2127 QCDCPLHFTGRFCEK 2141
Score = 30.8 bits (68), Expect = 4.7
Identities = 29/128 (22%), Positives = 42/128 (32%), Gaps = 21/128 (16%)
Query: 15 PALALLLLLLGAGPRGSSLAN-PVPAAPLSAPGPCAAQ-----PCRNGGVCTSRPEPDPQ 68
P ++LL G P SS P S G PC+NG C
Sbjct: 297 PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--- 353
Query: 69 HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYE 128
C C + C+ + C S P + +++ Y C C G+
Sbjct: 354 ---------VMCICSPIFTDLLCKSIQTSCESFPLRN---NATCKKCEKDYPCSCISGFT 401
Query: 129 GPNCEQAL 136
NCE+A+
Sbjct: 402 EKNCEKAI 409
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 250 bits (639), Expect = 3e-66
Identities = 123/327 (37%), Positives = 169/327 (51%), Gaps = 39/327 (11%)
Query: 327 TKPSEATFSCTCEEQYVGTFCEEYDA------------CQRKPCQNNASCIDANEKQDGS 374
T PSE +C + GT C+ ++ C +PC + A C+ + D +
Sbjct: 33 TVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVP--QGPDPT 90
Query: 375 NFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
F C C+PG+ G C+ ID C PC +GATC + + C CP GY G CE +VD C
Sbjct: 91 GFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150
Query: 435 ASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCL 492
AS+PC + G+C +DGV F C C+PG+ G C +D C PCAH GTC + ++C
Sbjct: 151 ASAPCLHGGSC-LDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCD 209
Query: 493 C-DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVS 551
C GY G +CE E EC SAPC + A+C + + + C+C Y G CE+ +D CA+
Sbjct: 210 CAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSP 269
Query: 552 CLNGATC---DSDGLNG------------------TCICAPGFTGEECDIDINECDSNPC 590
C +G C L G C C PGF G +C ++++EC S PC
Sbjct: 270 CQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPC 329
Query: 591 HHGGSCLDQPNGYNCHCPHGWVGANCE 617
+GG C D PNG+ CHCP G+ G CE
Sbjct: 330 LNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Score = 215 bits (548), Expect = 1e-55
Identities = 111/311 (35%), Positives = 143/311 (45%), Gaps = 33/311 (10%)
Query: 334 FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
+ C C Y G CE E D C PC + SC+D +F CVC PGY G CQ
Sbjct: 130 YECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGV-----GSFRCVCAPGYGGTRCQLD 184
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCP-EGYFGSACEEKVDPCASSPCQNNGTCYVDGVH 451
+D C PC +G TC ++GF C C GY G+ CE +V CAS+PC++N +C
Sbjct: 185 LDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGS 244
Query: 452 FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVG---------------------TSY 489
F C C PG++G C D CA SPC HG C +
Sbjct: 245 FRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGF 304
Query: 490 KCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCAN 549
C C PG+ G C E +EC S PCLN C+DL NG++C C Y G CE D C +
Sbjct: 305 LCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLS 364
Query: 550 VSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCL----DQPNGYNC 605
CL+G TC C C + G +C + + C + C +C+ + Y C
Sbjct: 365 DPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVC 424
Query: 606 HCPHGWVGANC 616
HCP G G C
Sbjct: 425 HCPPGTHGPFC 435
Score = 156 bits (395), Expect = 6e-38
Identities = 81/201 (40%), Positives = 107/201 (53%), Gaps = 18/201 (8%)
Query: 424 GSACEEKVDPCASSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT- 481
G+ E CAS PC C + +TC GP + CA PC HG
Sbjct: 32 GTVPSEPPSACASDPCAPGTECQATESGGYTC-------GPMEPR---GCATQPCHHGAL 81
Query: 482 CRSVG---TSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGT 538
C G T ++C C PG+ G CE + +EC S PC + ATCR+L + YEC C Y G
Sbjct: 82 CVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGV 141
Query: 539 HCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCL 597
CE+ D CA+ CL+G +C DG+ C+CAPG+ G C +D++EC S PC HGG+C
Sbjct: 142 TCEMEVDECASAPCLHGGSC-LDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCH 200
Query: 598 DQPNGYNCHCP-HGWVGANCE 617
D NG+ C C G+ G +CE
Sbjct: 201 DLVNGFRCDCAGTGYEGTHCE 221
Score = 116 bits (290), Expect = 9e-26
Identities = 67/219 (30%), Positives = 100/219 (45%), Gaps = 15/219 (6%)
Query: 472 CALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECV 530
CA SPC H G CR + ++ C C PG+ G CE + C SAPC +EC
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 531 CLAEYKGTHCEL---YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDS 587
C + G C L K+ NV+CL+G+ C+ C C G G+ C + C++
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESL-TNMPRHSLYIIIGAL 646
NPC +GG+C C C + G CE+ A+ L +P L + + A
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEV---------AKGLPLPLPFPLLEVAVPAA 1230
Query: 647 CVAFILMLIILIVGICRI-SRIEYQGSSRPAYEEFYNCR 684
C +L+L+ L+ GI R + +G+ P+ +E R
Sbjct: 1231 CACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGAR 1269
Score = 107 bits (268), Expect = 3e-23
Identities = 52/149 (34%), Positives = 72/149 (48%), Gaps = 10/149 (6%)
Query: 332 ATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQ 390
A F C C + G C E D C +PC N C D + F C C GY G C+
Sbjct: 302 AGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLP-----NGFQCHCPDGYAGPTCE 356
Query: 391 SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTC---YV 447
+D C+ DPC +G TC +++G+ C+CPE + G C ++ C C TC +
Sbjct: 357 EDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFE 416
Query: 448 DGVH-FTCNCSPGFTGPTCAQLIDFCALS 475
GVH + C+C PG GP C Q F ++
Sbjct: 417 SGVHSYVCHCPPGTHGPFCGQNTTFSVMA 445
Score = 103 bits (257), Expect = 6e-22
Identities = 57/155 (36%), Positives = 71/155 (45%), Gaps = 8/155 (5%)
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV--DGVHFT 453
C PC + C F C C G+ G CE VDPC S+PC G C+ DG F
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCA-RGRCHTHPDG-RFE 1117
Query: 454 CNCSPGFTGPTCAQLIDF--CALS-PCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNEC 509
C C PGF GP C + C+L+ C G+ C + C C G G C+ C
Sbjct: 1118 CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177
Query: 510 LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK 544
+ PCLN TCR EC+C A + G CE+ K
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 82.8 bits (203), Expect = 1e-15
Identities = 55/151 (36%), Positives = 65/151 (43%), Gaps = 38/151 (25%)
Query: 9 PGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSA------------------------ 44
PG ALA +LLLL P S LA VP+ P SA
Sbjct: 6 PGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTCGP 65
Query: 45 --PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP 102
P CA QPC +G +C PQ P P G + C C G G C+L D CAS P
Sbjct: 66 MEPRGCATQPCHHGALCV------PQGPDPTG---FRCYCVPGFQGPRCELDIDECASRP 116
Query: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
CHHG ++ + +D Y C C GY G CE
Sbjct: 117 CHHG---ATCRNLADRYECHCPLGYAGVTCE 144
Score = 77.8 bits (190), Expect = 3e-14
Identities = 44/136 (32%), Positives = 59/136 (43%), Gaps = 9/136 (6%)
Query: 334 FSCTCEEQYVGTFCEEY-DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
F+C C + G CE + D C PC + DG F C C PG+ G C+
Sbjct: 1078 FACACGPGWEGPRCEAHVDPCHSAPCARGR----CHTHPDG-RFECRCPPGFGGPRCRLP 1132
Query: 393 IDY--CILD-PCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDG 449
+ C L+ C +G+ C C C EG G C+ PC ++PC N GTC G
Sbjct: 1133 VPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAG 1192
Query: 450 VHFTCNCSPGFTGPTC 465
C C+ F+G C
Sbjct: 1193 GVSECICNARFSGQFC 1208
Score = 73.2 bits (178), Expect = 8e-13
Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPG---------YSCTCPAGISGANCQLVADPC 98
CA+ PC++GG C R +P A PG + C CP G GA+C + D C
Sbjct: 265 CASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDEC 324
Query: 99 ASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
AS PC +G +G+ C C +GY GP CE+
Sbjct: 325 ASRPCLNG---GHCQDLPNGFQCHCPDGYAGPTCEE 357
Score = 65.9 bits (159), Expect = 1e-10
Identities = 32/89 (35%), Positives = 43/89 (48%), Gaps = 15/89 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA++PC NGG C P G+ C CP G +G C+ D C S+PC HG
Sbjct: 324 CASRPCLNGGHCQDLPN------------GFQCHCPDGYAGPTCEEDVDECLSDPCLHGG 371
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
S + + GY+C C E + G +C L
Sbjct: 372 TCSDTVA---GYICRCPETWGGRDCSVQL 397
Score = 63.2 bits (152), Expect = 9e-10
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 12/131 (9%)
Query: 307 CVPG------ESHANDLECS--GKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPC 358
C PG E+H + + +G+C T P + F C C + G C K C
Sbjct: 1082 CGPGWEGPRCEAHVDPCHSAPCARGRCHTHP-DGRFECRCPPGFGGPRCRL--PVPSKEC 1138
Query: 359 QNNASCIDANEKQDGSNFT-CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
N +C+D + + GS C CL G G+ CQ C +PC NG TC ++ C
Sbjct: 1139 SLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECI 1198
Query: 418 CPEGYFGSACE 428
C + G CE
Sbjct: 1199 CNARFSGQFCE 1209
Score = 60.1 bits (144), Expect = 7e-09
Identities = 40/128 (31%), Positives = 55/128 (42%), Gaps = 23/128 (17%)
Query: 27 GPRGSSLANPVPAAPLSAPGPCAAQP-----CRN----GGVCTSRPEPDPQ--------- 68
GPR + +P +AP A G C P CR GG P P +
Sbjct: 1088 GPRCEAHVDPCHSAPC-ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLD 1146
Query: 69 -HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGY 127
P G P +C+C G++G CQ+ PC +NPC +G ++ S+ CICN +
Sbjct: 1147 GSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSE---CICNARF 1203
Query: 128 EGPNCEQA 135
G CE A
Sbjct: 1204 SGQFCEVA 1211
Score = 59.7 bits (143), Expect = 9e-09
Identities = 31/88 (35%), Positives = 39/88 (44%), Gaps = 16/88 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC +GG C G + C C G G CQL D C S PC HG
Sbjct: 150 CASAPCLHGGSCLD------------GVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHG- 196
Query: 108 CSSSSSSSSDGYLCIC-NEGYEGPNCEQ 134
+ +G+ C C GYEG +CE+
Sbjct: 197 --GTCHDLVNGFRCDCAGTGYEGTHCER 222
Score = 57.4 bits (137), Expect = 5e-08
Identities = 27/64 (42%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 432 DPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC-AHGTCRSVGTSYK 490
D C+ PC N GTC V F C C FTGPTCAQ + +C PC TC V +
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 491 CLCD 494
C+ +
Sbjct: 868 CVAE 871
Score = 56.2 bits (134), Expect = 1e-07
Identities = 29/103 (28%), Positives = 38/103 (36%), Gaps = 15/103 (14%)
Query: 36 PVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVA 95
P P CA PC + G C + ++C C G G C+
Sbjct: 1048 PAPILGCRGAPVCAPSPCLHDGACRDLFD------------AFACACGPGWEGPRCEAHV 1095
Query: 96 DPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138
DPC S PC G C + + C C G+ GP C +PS
Sbjct: 1096 DPCHSAPCARGRCHTHPDGR---FECRCPPGFGGPRCRLPVPS 1135
Score = 52.0 bits (123), Expect = 2e-06
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 30/103 (29%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-G 106
CA+ PC + C G + C C G SG C++ D CAS+PC H G
Sbjct: 227 CASAPCEHNASCLE------------GLGSFRCLCWPGYSGELCEVDEDECASSPCQHGG 274
Query: 107 NCSSSSSSS-----------------SDGYLCICNEGYEGPNC 132
C S + + G+LC C G+EG +C
Sbjct: 275 RCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADC 317
Score = 50.1 bits (118), Expect = 8e-06
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 16/87 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPA-GISGANCQLVADPCASNPCHHG 106
C +QPC +GG C G+ C C G G +C+ CAS PC H
Sbjct: 188 CQSQPCAHGGTCHDLVN------------GFRCDCAGTGYEGTHCEREVLECASAPCEH- 234
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
++S + C+C GY G CE
Sbjct: 235 --NASCLEGLGSFRCLCWPGYSGELCE 259
Score = 50.1 bits (118), Expect = 8e-06
Identities = 26/74 (35%), Positives = 33/74 (44%), Gaps = 2/74 (2%)
Query: 394 DYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFT 453
D C DPC NG TC+ + + F C CP + G C +++ C PC TC F
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 454 CNCSPGF-TGPTCA 466
C F GP A
Sbjct: 868 CVAEATFREGPPAA 881
Score = 47.8 bits (112), Expect = 4e-05
Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 2/68 (2%)
Query: 470 DFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYE 528
D C+ PC +G TC + C C + G C ++ C PCL ATC ++ +G+
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 529 CVCLAEYK 536
CV A ++
Sbjct: 868 CVAEATFR 875
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/88 (28%), Positives = 32/88 (36%), Gaps = 13/88 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
C + PC +GG C+ GY C CP G +C + C + C
Sbjct: 362 CLSDPCLHGGTCSDTVA------------GYICRCPETWGGRDCSVQLTGCQGHTCPLAA 409
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C S Y+C C G GP C Q
Sbjct: 410 TCIPIFESGVHSYVCHCPPGTHGPFCGQ 437
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/70 (31%), Positives = 30/70 (42%), Gaps = 6/70 (8%)
Query: 347 CEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGAT 406
C D C PC N +C+ ++F C C +TG C ++ +C PC AT
Sbjct: 805 CVSEDMCSPDPCFNGGTCL-----VTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPAT 858
Query: 407 CISSLSGFTC 416
C GF C
Sbjct: 859 CEEVPDGFVC 868
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 1/62 (1%)
Query: 544 KDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGY 603
+D C+ C NG TC + C C FTG C + C PC +C + P+G+
Sbjct: 808 EDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGF 866
Query: 604 NC 605
C
Sbjct: 867 VC 868
Score = 39.3 bits (90), Expect = 0.013
Identities = 16/41 (39%), Positives = 22/41 (53%)
Query: 429 EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
E+ + C PC + G+C HF C+C+ GPTCA I
Sbjct: 604 ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 5/67 (7%)
Query: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHC--ELYKDPCANVSCLNGATCDSDGLNGT 566
C PC N TC N + C C A + G C +L+ C CL ATC+
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW---CPGQPCLPPATCEEVPDGFV 867
Query: 567 CICAPGF 573
C+ F
Sbjct: 868 CVAEATF 874
Score = 38.9 bits (89), Expect = 0.017
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 1/41 (2%)
Query: 585 CDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSG 625
C +PC +GG+CL N ++C CP + G C L W G
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPG 850
Score = 36.6 bits (83), Expect = 0.086
Identities = 25/86 (29%), Positives = 34/86 (39%), Gaps = 21/86 (24%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC--QLVADPCASNPCHH 105
C+ PC NGG C + CTCPA +G C QL C PC
Sbjct: 811 CSPDPCFNGGTCLVTWND------------FHCTCPANFTGPTCAQQLW---CPGQPCLP 855
Query: 106 GNCSSSSSSSSDGYLCICNEGY-EGP 130
++ DG++C+ + EGP
Sbjct: 856 ---PATCEEVPDGFVCVAEATFREGP 878
Score = 33.9 bits (76), Expect = 0.56
Identities = 13/33 (39%), Positives = 16/33 (48%)
Query: 584 ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
+C PC HGGSC+D + C C G C
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 33.1 bits (74), Expect = 0.95
Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 7/61 (11%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C G C ++ F CTC + G C + C +PC A+C E DG F C
Sbjct: 816 CFNGGTCLVTWND--FHCTCPANFTGPTCAQQLWCPGQPCLPPATC---EEVPDG--FVC 868
Query: 379 V 379
V
Sbjct: 869 V 869
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540
D G + L E +C PC++ +C DL + C C ++G C
Sbjct: 594 DLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 5/47 (10%)
Query: 347 CEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKI 393
CE + C+ PC + SC+D ++F C C + G C +I
Sbjct: 603 CERREQCRPLPCVHGGSCVDL-----WTHFRCDCARPHRGPTCADEI 644
Score = 30.0 bits (66), Expect = 8.0
Identities = 9/32 (28%), Positives = 17/32 (53%)
Query: 400 PCRNGATCISSLSGFTCQCPEGYFGSACEEKV 431
PC +G +C+ + F C C + G C +++
Sbjct: 613 PCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 248 bits (633), Expect = 1e-65
Identities = 126/311 (40%), Positives = 161/311 (51%), Gaps = 17/311 (5%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C S +F C C + GT CEE D C C ++CID +F+
Sbjct: 326 CRNGGTCQN--SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRV-----GSFS 378
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISS-LSGFT-CQCPEGYFGSACEEKVDPC- 434
C+C PG TG LC + D C+ PC A C ++ L+G T C C GY G C + +D C
Sbjct: 379 CLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECL 437
Query: 435 ----ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSY 489
SPC++ G+C F C C PG+TG C + C PC G TC + ++
Sbjct: 438 MAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATF 497
Query: 490 KCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCAN 549
CLC PG G CE E NEC SAPCLN A C DL+NG++C+CL + GT CE D C +
Sbjct: 498 HCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRS 557
Query: 550 VSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPH 609
C NG C C C PGF G C +++EC S+PC G SCLD P + C CP
Sbjct: 558 SPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPS 617
Query: 610 GWVGANCEIHL 620
G+ G CE+ L
Sbjct: 618 GFTGQLCEVPL 628
Score = 243 bits (621), Expect = 4e-64
Identities = 119/312 (38%), Positives = 161/312 (51%), Gaps = 20/312 (6%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRKPCQNNASCIDANEKQDGSNFT 377
C+ G C +PS ++CTC Y G C EE AC PC N SC N G +
Sbjct: 700 CAHGGTCYPQPSG--YNCTCPTGYTGPTCSEEMTACHSGPCLNGGSC---NPSPGG--YY 752
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDP-CAS 436
C C P +TG CQ+ DYC+ PC NG TC++ F+C C G+ G CE K+ P CA
Sbjct: 753 CTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCAD 812
Query: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT-CRSVGTSYKCLCDP 495
SPC+N TC C C G+TG +C L+D CA PC + C G S+ CLC
Sbjct: 813 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQ 872
Query: 496 GYHGLYCEEEYNEC----------LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKD 545
G+ G C + C +S+ C N C D Y C C ++G+ C+ + +
Sbjct: 873 GWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVN 932
Query: 546 PCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNC 605
PC + C NGATC + C CAPG+ G+ C +++ C S PCH+ G+C +P G++C
Sbjct: 933 PCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHC 992
Query: 606 HCPHGWVGANCE 617
CP G+VG CE
Sbjct: 993 ACPPGFVGLRCE 1004
Score = 221 bits (563), Expect = 2e-57
Identities = 116/330 (35%), Positives = 148/330 (44%), Gaps = 22/330 (6%)
Query: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
TC + + C G C PS + CTC + G C+ D C PC N +C
Sbjct: 725 TCSEEMTACHSGPCLNGGSCN--PSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTC 782
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKI-DYCILDPCRNGATCISSLSGFTCQCPEGYF 423
++ F+C+C G+ G C+ K+ C PCRN ATC S G C CP GY
Sbjct: 783 VNRP-----GTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYT 837
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA---------L 474
G +C+ +D CA PC N C G F C C G+TGP C + C +
Sbjct: 838 GGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDV 897
Query: 475 SPCAH--GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532
S H G C G SY C C PG+ G C++ N C S PC N ATC +GY C C
Sbjct: 898 SSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCA 957
Query: 533 AEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHH 592
Y G +C D C + C N TC C C PGF G C+ D++EC PCH
Sbjct: 958 PGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHP 1017
Query: 593 GG--SCLDQPNGYNCHCPHGWVGANCEIHL 620
G +C N + C C G G CE+ +
Sbjct: 1018 TGTAACHSLANAFYCQCLPGHTGQWCEVEI 1047
Score = 211 bits (538), Expect = 1e-54
Identities = 108/285 (37%), Positives = 139/285 (48%), Gaps = 17/285 (5%)
Query: 334 FSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
F C C + GT CEE D C+ PC N C D Q G+ F C CLPG+ G CQ++
Sbjct: 535 FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQD----QPGA-FHCKCLPGFEGPRCQTE 589
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
+D C+ DPC GA+C+ F C CP G+ G CE V CA + CQ C
Sbjct: 590 VDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE--VPLCAPNLCQPKQICKDQKDKA 647
Query: 453 TCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C G P CA D C C HG C+ C+CD G+ G CE E C+SA
Sbjct: 648 NCLCPDG--SPGCAPPEDNCT---CHHGHCQRSS----CVCDVGWTGPECEAELGGCISA 698
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
PC + TC +GY C C Y G C C + CLNG +C+ C C P
Sbjct: 699 PCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPS 758
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
TG +C + C S PC +GG+C+++P ++C C G+ G CE
Sbjct: 759 HTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803
Score = 204 bits (520), Expect = 2e-52
Identities = 121/333 (36%), Positives = 154/333 (46%), Gaps = 23/333 (6%)
Query: 307 CVPG-ESHANDL---EC-SGKGKCTTKPS----EATFSCTCEEQYVGTFCE-EYDACQRK 356
C PG E HA + EC G C S +F C C G CE C +
Sbjct: 182 CPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPR 241
Query: 357 PCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTC 416
C N +C EK D + C+C PG+ G C+ D C+ C+NG TC L +TC
Sbjct: 242 GCSNGGTCQLMPEK-DSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC 300
Query: 417 QCPEGYFGSACEEKVDPCASS---PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
CPE + G C E VD C + C+N GTC F C C G+ G +C + +D C
Sbjct: 301 LCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCI 360
Query: 474 LSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATC--RDLVNGYECV 530
+ CA G TC S+ CLC PG GL C E + CLS PC A C L C+
Sbjct: 361 AATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCL 419
Query: 531 CLAEYKGTHCELYKDPCANVS-----CLNGATCDSDGLNGTCICAPGFTGEECDIDINEC 585
C Y G C D C C +G +C + + C+C PG+TG C+ D NEC
Sbjct: 420 CQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC 479
Query: 586 DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
S PCH G +CLD ++C CP G G CE+
Sbjct: 480 LSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEV 512
Score = 197 bits (500), Expect = 4e-50
Identities = 97/284 (34%), Positives = 138/284 (48%), Gaps = 28/284 (9%)
Query: 356 KPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL---- 411
+PC N +C+ + Q TC C PG+ GE CQ C+NG +C + L
Sbjct: 33 EPCANGGTCLSLSLGQG----TCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPL 88
Query: 412 ----------SGFTCQCPEGYFGSACEEKV-DPCASSPCQNNGTCYVDGV-HFTCNCSPG 459
F C C G+ G C+ K+ DPC S C G C++ C+C PG
Sbjct: 89 GLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPG 148
Query: 460 FTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLS--APCLN 516
+TG C QL DFC+ +PC + G C + +C C PG+ G CE + NEC PC
Sbjct: 149 WTGEQC-QLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPK 207
Query: 517 AATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC----DSDGLNGTCICAPG 572
+C + + ++C+C +G CEL PC C NG TC + D C+C PG
Sbjct: 208 GTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPG 267
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
F G +C+++ + C S+ C +GG+C D + Y C CP W G +C
Sbjct: 268 FIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDC 311
Score = 196 bits (499), Expect = 5e-50
Identities = 118/419 (28%), Positives = 162/419 (38%), Gaps = 113/419 (26%)
Query: 306 TCVPGESHANDLECSGKGKC------------TTKPSEATFSCTCEEQYVGTFCEEY--D 351
TC + N C G C + P +F CTC + G C+ D
Sbjct: 61 TCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED 120
Query: 352 ACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL 411
C C C Q C C+PG+TGE CQ + D+C +PC NG C+++
Sbjct: 121 PCPPSFCSKRGRC----HIQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATY 175
Query: 412 SGFTCQCPEGYFGSACEEKVDPCASSP--------------------------------- 438
C CP G+ G ACE V+ C P
Sbjct: 176 PQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRA 235
Query: 439 -------CQNNGTCYV----DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-------- 479
C N GTC + D C C PGF GP C D C C +
Sbjct: 236 GPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGL 295
Query: 480 ----------------------------------GTCRSVGTSYKCLCDPGYHGLYCEEE 505
GTC++ S+ C+C G+ G CEE
Sbjct: 296 DTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEEN 355
Query: 506 YNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG 565
++C++A C +TC D V + C+C G C L +D C + C A C ++ L G
Sbjct: 356 LDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHL-EDMCLSQPCHGDAQCSTNPLTG 414
Query: 566 T--CICAPGFTGEECDIDINEC-----DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
+ C+C PG++G C D++EC +PC HGGSCL+ P +NC CP G+ G+ CE
Sbjct: 415 STLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Score = 194 bits (493), Expect = 2e-49
Identities = 101/312 (32%), Positives = 140/312 (44%), Gaps = 32/312 (10%)
Query: 333 TFSCTCEEQYVGTFCE-EYDACQRKP----------CQNNASCIDANEKQDGSNFTCVCL 381
+F C C + + G C +CQ+ C N C+D+ G ++ C C
Sbjct: 865 SFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDS-----GPSYFCHCP 919
Query: 382 PGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQN 441
PG+ G LCQ ++ C PC+NGATC++ SG+ CQC GY G C +++D C S PC N
Sbjct: 920 PGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHN 979
Query: 442 NGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC---AHGTCRSVGTSYKCLCDPGYH 498
+GTC F C C PGF G C +D C PC C S+ ++ C C PG+
Sbjct: 980 HGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHT 1039
Query: 499 GLYCEEEYNECLSAPCLNAATCRDLVN---GYECVCLAEYKGTHCELYKDPCANVSCLNG 555
G +CE E + C S PC + TC G+ C C ++G C C C +G
Sbjct: 1040 GQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHG 1099
Query: 556 ATC---DSDGLNGTCICAPGFTGEEC---DIDINECDSNPCHHGGSCLDQPN----GYNC 605
C G C C G+ G +C +PC + GSC + G+ C
Sbjct: 1100 GLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRC 1159
Query: 606 HCPHGWVGANCE 617
CPH G C+
Sbjct: 1160 SCPHSSPGPRCQ 1171
Score = 183 bits (464), Expect = 6e-46
Identities = 171/639 (26%), Positives = 226/639 (35%), Gaps = 157/639 (24%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGG C +P+P G Y CTCP +G CQ D C S PC +G
Sbjct: 733 CHSGPCLNGGSC---------NPSPGG---YYCTCPPSHTGPQCQTSTDYCVSAPCFNGG 780
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILP 167
+ + + C+C G++GP CE L A + A Q P Q P + P
Sbjct: 781 TCVNRPGT---FSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSP----QGPRCLCP 833
Query: 168 RSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVK 227
+ T QK ++ P C
Sbjct: 834 TGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHC------------------------L 869
Query: 228 IRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVND 287
Q T L + + Q+ +L G V+ L +GGL + G ++F
Sbjct: 870 CLQGWTGPLC---NLPLSSCQKAALSQGIDVSSLCHNGGL-----CVDSGPSYF------ 915
Query: 288 SVTKSIVALRLTLVVKVSTCVPG------ESHANDLE---CSGKGKCTTKPSEATFSCTC 338
C PG + H N E C C +PS + C C
Sbjct: 916 -----------------CHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPS--GYLCQC 956
Query: 339 EEQYVGTFC-EEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCI 397
Y G C +E DACQ +PC N+ +C K G F C C PG+ G C+ +D C+
Sbjct: 957 APGYDGQNCSKELDACQSQPCHNHGTC---TPKPGG--FHCACPPGFVGLRCEGDVDECL 1011
Query: 398 LDPCR--NGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDG---VHF 452
PC A C S + F CQC G+ G CE ++DPC S PC + GTC + F
Sbjct: 1012 DQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGF 1071
Query: 453 TCNCSPGFTGPTCAQLIDFCALSPCAHG----TCRSVGTSYKCLCDPGYHGLYC--EEEY 506
C+C GF GPTC+ C C HG G +C C GY G C
Sbjct: 1072 ICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAP 1131
Query: 507 NEC-LSAPCLNAATCRDLVN----GYECVCLAEYKGTHCELYKDPCANVSCLNG-----A 556
C +PCL +C + G+ C C G C+ K +G A
Sbjct: 1132 KGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ--KPGAKGCEGRSGDGACDA 1189
Query: 557 TCDSDGLN---GTCI------------------------CAPGFTGEECDIDINECDSNP 589
C G N G C C P EEC D +C++ P
Sbjct: 1190 GCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPP 1249
Query: 590 ---------CH---HGGSCLDQPNGYNCHCPHGWVGANC 616
CH H G C N C GW G +C
Sbjct: 1250 ACTPAYDQYCHDHFHNGHCEKGCNTAEC----GWDGGDC 1284
Score = 129 bits (325), Expect = 7e-30
Identities = 85/267 (31%), Positives = 120/267 (44%), Gaps = 32/267 (11%)
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCIS-SLSGFTCQCPEGYFGSACEEKVDPCAS 436
CV + G LC S +PC NG TC+S SL TCQC G+ G C+ DPC +
Sbjct: 17 CVSVVRPRGLLCGS-----FPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQN 70
Query: 437 SP-CQNNGTCYVD--------------GVHFTCNCSPGFTGPTC-AQLIDFCALSPCA-H 479
+ CQN G+C F C C PGFTG C A+L D C S C+
Sbjct: 71 AQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKR 130
Query: 480 GTCRSVGTSY-KCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGT 538
G C + +C C PG+ G C+ + C + PC+N C +C C ++G
Sbjct: 131 GRCHIQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGH 189
Query: 539 HCELYKDPCANVS--CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSC 596
CE + C C G +C + + C+C G G C++ C C +GG+C
Sbjct: 190 ACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTC 249
Query: 597 LDQPNG----YNCHCPHGWVGANCEIH 619
P + C CP G++G +CE++
Sbjct: 250 QLMPEKDSTFHLCLCPPGFIGPDCEVN 276
Score = 68.6 bits (166), Expect = 2e-11
Identities = 32/88 (36%), Positives = 40/88 (45%), Gaps = 17/88 (19%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-H 105
PC ++PC+NG C ++P GY C C G G NC D C S PCH H
Sbjct: 933 PCESRPCQNGATCMAQPS------------GYLCQCAPGYDGQNCSKELDACQSQPCHNH 980
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G C+ G+ C C G+ G CE
Sbjct: 981 GTCTPKPG----GFHCACPPGFVGLRCE 1004
Score = 66.2 bits (160), Expect = 1e-10
Identities = 31/88 (35%), Positives = 40/88 (45%), Gaps = 15/88 (17%)
Query: 46 GPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105
G C + PC +GG C +P GY+CTCP G +G C C S PC +
Sbjct: 693 GGCISAPCAHGGTCYPQPS------------GYNCTCPTGYTGPTCSEEMTACHSGPCLN 740
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G S + S GY C C + GP C+
Sbjct: 741 G---GSCNPSPGGYYCTCPPSHTGPQCQ 765
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/87 (37%), Positives = 38/87 (43%), Gaps = 11/87 (12%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEP-GYSCTCPAGISGANCQLVADPCASNPCHH 105
PC +QPC +GG C A AG P G+ C CP G G C A C + CHH
Sbjct: 1049 PCHSQPCFHGGTCE----------ATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHH 1098
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNC 132
G S C C GY GP+C
Sbjct: 1099 GGLCLPSPKPGFPPRCACLSGYGGPDC 1125
Score = 63.2 bits (152), Expect = 9e-10
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 23/131 (17%)
Query: 25 GAGPRGSSLANPVPAAPLSAP------------GPCAAQPCRNGGVCTSRPEPDPQHPAP 72
G P+G+S N + + P GPC + C NGG C PE D
Sbjct: 203 GPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTF--- 259
Query: 73 AGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNC 132
+ C CP G G +C++ D C S+ C +G + D Y C+C E + G +C
Sbjct: 260 -----HLCLCPPGFIGPDCEVNPDNCVSHQCQNG---GTCQDGLDTYTCLCPETWTGWDC 311
Query: 133 EQALPSLPATG 143
+ + G
Sbjct: 312 SEDVDECETQG 322
Score = 62.4 bits (150), Expect = 1e-09
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 31/116 (26%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAG---------------EPG--------------Y 78
C+A PC NGGVC + P Q P G +PG +
Sbjct: 160 CSANPCVNGGVCLAT-YPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSF 218
Query: 79 SCTCPAGISGANCQLVADPCASNPCHH-GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
C CP G G C+L A PC C + G C S +LC+C G+ GP+CE
Sbjct: 219 QCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCE 274
Score = 60.1 bits (144), Expect = 7e-09
Identities = 32/89 (35%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C A C G C R +SC CP G +G C L D C S PCH G+
Sbjct: 359 CIAATCAPGSTCIDRVG------------SFSCLCPPGRTGLLCHL-EDMCLSQPCH-GD 404
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
S++ + LC+C GY GP C Q L
Sbjct: 405 AQCSTNPLTGSTLCLCQPGYSGPTCHQDL 433
Score = 59.7 bits (143), Expect = 9e-09
Identities = 38/108 (35%), Positives = 49/108 (45%), Gaps = 20/108 (18%)
Query: 529 CVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLN-GTCICAPGFTGEECDIDINECDS 587
CV + +G C + +PCAN G TC S L GTC CAPGF GE C ++
Sbjct: 17 CVSVVRPRGLLCGSFPEPCAN-----GGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNA 71
Query: 588 NPCHHGGSC---LDQPNG-----------YNCHCPHGWVGANCEIHLQ 621
C +GGSC L P G + C C G+ G C+ L+
Sbjct: 72 QLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLE 119
Score = 55.8 bits (133), Expect = 1e-07
Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 15/89 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGG C +P + C C G G CQ D C S+PC G
Sbjct: 555 CRSSPCANGGQCQDQPG------------AFHCKCLPGFEGPRCQTEVDECLSDPCPVG- 601
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+S + C+C G+ G CE L
Sbjct: 602 --ASCLDLPGAFFCLCPSGFTGQLCEVPL 628
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/113 (30%), Positives = 46/113 (40%), Gaps = 29/113 (25%)
Query: 35 NPVPAA-----PLSAPGP--------CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT 81
NP P P S GP C + PC NGG C +RP +SC
Sbjct: 745 NPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGT------------FSCL 792
Query: 82 CPAGISGANCQLVADP-CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
C G G C+ P CA +PC + ++ S G C+C GY G +C+
Sbjct: 793 CAMGFQGPRCEGKLRPSCADSPCRN---RATCQDSPQGPRCLCPTGYTGGSCQ 842
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/119 (26%), Positives = 49/119 (41%), Gaps = 18/119 (15%)
Query: 15 PALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAG 74
P L L G G + + ++ GP PC +GG C + P
Sbjct: 411 PLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGP---SPCEHGGSCLNTPG---------- 457
Query: 75 EPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
++C CP G +G+ C+ + C S PCH G+ ++ + C+C G EG CE
Sbjct: 458 --SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLAT---FHCLCPPGLEGQLCE 511
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 17/88 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C +QPC G C + C CP G+ G C++ + CAS PC +H
Sbjct: 479 CLSQPCHPGSTCLDLLAT------------FHCLCPPGLEGQLCEVETNECASAPCLNHA 526
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+C +G+ CIC G+ G CE+
Sbjct: 527 DC----HDLLNGFQCICLPGFSGTRCEE 550
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/86 (30%), Positives = 34/86 (39%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC N C G+ C C G SG C+ D C S+PC +G
Sbjct: 517 CASAPCLNHADCHDLLN------------GFQCICLPGFSGTRCEEDIDECRSSPCANG- 563
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ C C G+EGP C+
Sbjct: 564 --GQCQDQPGAFHCKCLPGFEGPRCQ 587
Score = 49.7 bits (117), Expect = 1e-05
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 79 SCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
SC C G +G C+ C S PC HG S GY C C GY GP C + +
Sbjct: 676 SCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPS---GYNCTCPTGYTGPTCSEEM 730
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/142 (30%), Positives = 54/142 (38%), Gaps = 37/142 (26%)
Query: 7 QAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPD 66
Q P LL L LLL + PRG L P +PC NGG C S
Sbjct: 2 QPPSLLLLLLLLLLLCVSVVRPRGL-LCGSFP------------EPCANGGTCLS----- 43
Query: 67 PQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP-CHHG-NCS----------SSSSS 114
G+ +C C G G CQ DPC + C +G +C SS S
Sbjct: 44 ----LSLGQG--TCQCAPGFLGETCQF-PDPCQNAQLCQNGGSCQALLPAPLGLPSSPSP 96
Query: 115 SSDGYLCICNEGYEGPNCEQAL 136
+ +LC C G+ G C+ L
Sbjct: 97 LTPSFLCTCLPGFTGERCQAKL 118
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 20/114 (17%)
Query: 36 PVPAAPLSAPGP------CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGY---------SC 80
P P S+P P C P G C ++ E DP P+ + G C
Sbjct: 85 PAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLE-DPCPPSFCSKRGRCHIQASGRPQC 143
Query: 81 TCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+C G +G CQL D C++NPC +G ++ C C G+EG CE+
Sbjct: 144 SCMPGWTGEQCQL-RDFCSANPCVNGGVCLATYPQIQ---CHCPPGFEGHACER 193
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 247 bits (631), Expect = 2e-65
Identities = 124/314 (39%), Positives = 154/314 (49%), Gaps = 32/314 (10%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDG-SNF 376
C G C P C C Y G FCE ++D C PCQN A C QDG +
Sbjct: 119 CQHGGICHQDPIYPV--CICPAGYAGRFCEIDHDECASSPCQNGAVC------QDGIDGY 170
Query: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS 436
+C C+PGY G C ++D C DPC+N ATC++ + +TC CP Y G CE ++D C S
Sbjct: 171 SCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWS 230
Query: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLC-D 494
PC N TC + C+C+PGF G C D CA PC H G C Y C C
Sbjct: 231 QPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTG 290
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLN 554
G+ G +CE C S PC N ATC D V+ Y C C Y G CE+ + C + C +
Sbjct: 291 SGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQS 350
Query: 555 GATC---DSDGLNG-----------------TCICAPGFTGEECDIDINECDSNPCHHGG 594
C S+ G CIC PGFTG C+ D+NEC SNPC +GG
Sbjct: 351 NGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGG 410
Query: 595 SCLDQPNGYNCHCP 608
+C + P Y CHCP
Sbjct: 411 TCENLPGNYTCHCP 424
Score = 240 bits (612), Expect = 4e-63
Identities = 121/331 (36%), Positives = 166/331 (50%), Gaps = 8/331 (2%)
Query: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DA 352
++ L + +K S C + C C + SC+ + C+ D
Sbjct: 14 LSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDP 73
Query: 353 CQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLS 412
C PCQ +A+C++ ++ +F C C PGY+G +C++ I C + C++G C
Sbjct: 74 CFSNPCQGSATCVNTPGER---SFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPI 130
Query: 413 GFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDF 471
C CP GY G CE D CASSPCQN C DG+ ++C C PG+ G C +D
Sbjct: 131 YPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQ-DGIDGYSCFCVPGYQGRHCDLEVDE 189
Query: 472 CALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECV 530
CA PC + TC + Y C+C Y G+ CE E +EC S PCLN ATC+D + Y C
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCD 249
Query: 531 CLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCIC-APGFTGEECDIDINECDSNP 589
C + G HCEL D CA+ CL+G C +C C GFTG C+ + C S P
Sbjct: 250 CAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKP 309
Query: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
CH+ +C D + Y CHC G+ GA CEI L
Sbjct: 310 CHNNATCEDSVDNYTCHCWPGYTGAQCEIDL 340
Score = 177 bits (449), Expect = 3e-44
Identities = 89/258 (34%), Positives = 133/258 (51%), Gaps = 19/258 (7%)
Query: 430 KVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSY 489
+++ C S+PC + G C + C+C G++G C ID C +PC HG C +Y
Sbjct: 1139 QLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAY 1198
Query: 490 KCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC-- 547
C C+PGY G+ CE + + C S C N ATC NGY C+C + G C + P
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258
Query: 548 -----ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
N++C NG C C+C PGFTGE C+ DI+EC S+PC +GG C D N
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318
Query: 603 YNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIV-GI 661
+ C C + G CE+ L A+ L + ++ IG++ VA +L+L++ IV +
Sbjct: 1319 FQCLCDVAFAGERCEVDL-------ADDLIS----DIFTTIGSVTVALLLILLLAIVASV 1367
Query: 662 CRISRIEYQGSSRPAYEE 679
++ QG+ P+ +E
Sbjct: 1368 VTSNKRATQGTYSPSRQE 1385
Score = 147 bits (370), Expect = 5e-35
Identities = 135/509 (26%), Positives = 204/509 (40%), Gaps = 76/509 (14%)
Query: 28 PRGSSLANPV---PAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPA 84
P ++ NPV + C + PC NGGVC SR + +SC+CPA
Sbjct: 868 PTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWDD------------FSCSCPA 915
Query: 85 GISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS-----L 139
SG C+ V C +PC HG + G+ CI N + G + + S
Sbjct: 916 LTSGKACEEV-QWCGFSPCPHG---AQCQPVLQGFECIANAVFNGQSGQILFRSNGNITR 971
Query: 140 PATGWTESMAPRQLQPV--PATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVI 197
T T R + A +EP+ + Q + +Q ++G + ++ +
Sbjct: 972 ELTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLF--FQLQSGNSFYMLSLTSLQSV 1029
Query: 198 PD-------IACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQC 250
D ++ + S +S V E P TS AT SL L T
Sbjct: 1030 NDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTI----ATGSLNFLKDNTDI----- 1080
Query: 251 SLIDGRSVTPLQASGGLVLLEEMLALGNNHFI---GFVNDSVTKSIVALRLTLVV----K 303
+ R++ ++ G + E+ + ++F GF+N + + + VV +
Sbjct: 1081 -YVGDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQ 1139
Query: 304 VSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNA 362
++ C N C G C + +++ C+C + G CE D C PC
Sbjct: 1140 LNVC-------NSNPCLHGGNC--EDIYSSYHCSCPLGWSGKHCELNIDECFSNPC---- 1186
Query: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY 422
I N + + C C PGYTG C+ ID C C NGATCIS +G++C C +
Sbjct: 1187 --IHGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNF 1244
Query: 423 FGSACEEKVDP---CASS----PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALS 475
G C + P C + C N G C C C PGFTG C + ID CA
Sbjct: 1245 TGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASD 1304
Query: 476 PCAH-GTCRSVGTSYKCLCDPGYHGLYCE 503
PC + G C+ + ++CLCD + G CE
Sbjct: 1305 PCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Score = 75.9 bits (185), Expect = 1e-13
Identities = 55/206 (26%), Positives = 78/206 (37%), Gaps = 85/206 (41%)
Query: 307 CVPGESHANDLECSGKG-----------KCTTKP---------SEATFSCTCEEQYVGTF 346
CV GE+ + C+G G C +KP S ++C C Y G
Sbjct: 277 CVDGENRYS-CNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQ 335
Query: 347 CE-EYDACQRKPCQNNASCID-ANEKQDG--------------SNFTCVCLPGYTGELCQ 390
CE + + C PCQ+N C++ ++EKQ G S + C+C PG+TG C+
Sbjct: 336 CEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE 395
Query: 391 SKIDYCILDPCRNGATC------------ISSLS-------------------------- 412
++ C +PC+NG TC +LS
Sbjct: 396 EDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGT 455
Query: 413 ----------GFTCQCPEGYFGSACE 428
GF+C CP GY GS CE
Sbjct: 456 CIPHFQDGQHGFSCLCPSGYTGSLCE 481
Score = 68.2 bits (165), Expect = 3e-11
Identities = 32/88 (36%), Positives = 45/88 (51%), Gaps = 15/88 (17%)
Query: 46 GPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105
G C C++GG+C DP +P C CPAG +G C++ D CAS+PC +
Sbjct: 112 GSCGKNSCQHGGIC----HQDPIYPV--------CICPAGYAGRFCEIDHDECASSPCQN 159
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G + DGY C C GY+G +C+
Sbjct: 160 G---AVCQDGIDGYSCFCVPGYQGRHCD 184
Score = 67.4 bits (163), Expect = 5e-11
Identities = 33/86 (38%), Positives = 41/86 (47%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC+NG VC G GYSC C G G +C L D CAS+PC +
Sbjct: 152 CASSPCQNGAVCQD------------GIDGYSCFCVPGYQGRHCDLEVDECASDPCKN-- 197
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
++ + Y CIC Y G NCE
Sbjct: 198 -EATCLNEIGRYTCICPHNYSGVNCE 222
Score = 64.3 bits (155), Expect = 4e-10
Identities = 32/87 (36%), Positives = 44/87 (50%), Gaps = 16/87 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCP-AGISGANCQLVADPCASNPCHHG 106
CA+QPC +GG+C GE YSC C +G +G +C+ + C S PCH+
Sbjct: 266 CASQPCLHGGLCVD------------GENRYSCNCTGSGFTGTHCETLMPLCWSKPCHN- 312
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
+++ S D Y C C GY G CE
Sbjct: 313 --NATCEDSVDNYTCHCWPGYTGAQCE 337
Score = 58.5 bits (140), Expect = 2e-08
Identities = 28/87 (32%), Positives = 34/87 (39%), Gaps = 13/87 (14%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
PC + PC+ C + P GE + C CP G SG C+ C N C HG
Sbjct: 73 PCFSNPCQGSATCVNTP----------GERSFLCKCPPGYSGTICETTIGSCGKNSCQHG 122
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
+CIC GY G CE
Sbjct: 123 GICHQDPIYP---VCICPAGYAGRFCE 146
Score = 58.2 bits (139), Expect = 3e-08
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPG-YSCTCPAGISGANCQLVADPCASNPCHHG 106
CA+ PC+N C + E G Y+C CP SG NC+L D C S PC +G
Sbjct: 190 CASDPCKNEATCLN-------------EIGRYTCICPHNYSGVNCELEIDECWSQPCLNG 236
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
++ + Y C C G+ G +CE
Sbjct: 237 ---ATCQDALGAYFCDCAPGFLGDHCE 260
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 29/104 (27%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
C ++PC N C + Y+C C G +GA C++ + C SNPC +G
Sbjct: 305 CWSKPCHNNATCEDSVD------------NYTCHCWPGYTGAQCEIDLNECNSNPCQSNG 352
Query: 107 NC----------------SSSSSSSSDGYLCICNEGYEGPNCEQ 134
C SS S + GY+CIC G+ G +CE+
Sbjct: 353 ECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEE 396
Score = 57.8 bits (138), Expect = 4e-08
Identities = 20/41 (48%), Positives = 30/41 (73%)
Query: 580 IDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
+ +N C+SNPC HGG+C D + Y+C CP GW G +CE+++
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNI 1178
Score = 55.8 bits (133), Expect = 1e-07
Identities = 30/91 (32%), Positives = 37/91 (40%), Gaps = 16/91 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +QPC NG C Y C C G G +C+L D CAS PC HG
Sbjct: 228 CWSQPCLNGATCQD------------ALGAYFCDCAPGFLGDHCELNTDECASQPCLHGG 275
Query: 108 CSSSSSSSSDGYLCIC-NEGYEGPNCEQALP 137
+ Y C C G+ G +CE +P
Sbjct: 276 LCVDGENR---YSCNCTGSGFTGTHCETLMP 303
Score = 52.0 bits (123), Expect = 2e-06
Identities = 88/382 (23%), Positives = 123/382 (32%), Gaps = 95/382 (24%)
Query: 309 PGESHANDLECSGK---GKCTTKPSEATFS------CTCEEQYVGTFCEE-YDACQRKPC 358
P +S+ +E S + G+ T PS ++ C C+ + G CEE + C PC
Sbjct: 347 PCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPC 406
Query: 359 QNNASCIDANEKQDGSNFTCVC------LPGYTGELCQSKIDYCILDPCRNGATCISSLS 412
QN +C E G N+TC C Y G C + C C N TCI
Sbjct: 407 QNGGTC----ENLPG-NYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQ 461
Query: 413 GFTCQCPEGYFGSACEEKVDPCAS----SPCQNNGTCYVDGVHFTCNCSPGFT--GPTCA 466
+G G +C C S S C+ T +G F S T G C
Sbjct: 462 -------DGQHGFSCL-----CPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVCN 509
Query: 467 QLIDFCALSPCAHGTCRS--------------------VGTSYKCLCDPGYHGLYCEEEY 506
+ F + P A RS V K L ++ E +
Sbjct: 510 IALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHF 569
Query: 507 NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGT 566
E + A + D +C+ A T E + CA + G NG
Sbjct: 570 VEVIFAEAVTLTLIDDSCKE-KCIAKAP---TPLESDQSICAFQNSFLGGLPVGMTSNGV 625
Query: 567 CIC-------APGFTG--EECDIDINE-----------------------CDSNPCHHGG 594
+ P F G ++ ID N C+S PC G
Sbjct: 626 ALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVRKDWCESQPCQSRG 685
Query: 595 SCLDQPNGYNCHCPHGWVGANC 616
C++ Y C C + G NC
Sbjct: 686 RCINLWLSYQCDCHRPYEGPNC 707
Score = 50.8 bits (120), Expect = 4e-06
Identities = 27/95 (28%), Positives = 38/95 (40%), Gaps = 19/95 (20%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAG------ISGANCQLVADPCASN 101
C++ PC+NGG C + P Y+C CP G +C + C
Sbjct: 401 CSSNPCQNGGTCENLPG------------NYTCHCPFDNLSRTFYGGRDCSDILLGCTHQ 448
Query: 102 PC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
C ++G C G+ C+C GY G CE A
Sbjct: 449 QCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA 483
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/91 (27%), Positives = 38/91 (41%), Gaps = 11/91 (12%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + C+N C + + SC+ A +C + DPC SNPC G+
Sbjct: 34 CLSNSCQNNSTCKDFSKDND----------CSCSDTANNLDKDCDNMKDPCFSNPC-QGS 82
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138
+ ++ +LC C GY G CE + S
Sbjct: 83 ATCVNTPGERSFLCKCPPGYSGTICETTIGS 113
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 19/104 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEP---------GYSCTCPAGISGANCQLVADPC 98
C + PC++ G C + Q+ G P GY C C G +G +C+ + C
Sbjct: 343 CNSNPCQSNGECVELSS-EKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNEC 401
Query: 99 ASNPCHHGNCSSSSSSSSDGYLCIC------NEGYEGPNCEQAL 136
+SNPC +G + + Y C C Y G +C L
Sbjct: 402 SSNPCQNG---GTCENLPGNYTCHCPFDNLSRTFYGGRDCSDIL 442
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCH 606
C + C NG C S + +C C +G+ C+ ++ C +PC HG C G+ C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 607 CPHGWVGANCEIHLQWKSGHMAESLTNM 634
+ G + +I L +G++ LTN+
Sbjct: 950 ANAVFNGQSGQI-LFRSNGNITRELTNI 976
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 2/67 (2%)
Query: 472 CALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECV 530
C +PC +G C S + C C G CEE C +PC + A C+ ++ G+EC+
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 531 CLAEYKG 537
A + G
Sbjct: 950 ANAVFNG 956
Score = 43.9 bits (102), Expect = 5e-04
Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 583 NECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQW 622
N C SNPCH+GG C + + ++C CP G CE +QW
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQW 927
Score = 38.1 bits (87), Expect = 0.030
Identities = 23/74 (31%), Positives = 28/74 (37%), Gaps = 1/74 (1%)
Query: 507 NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGT 566
N C S PC N C + + C C A G CE + C C +GA C
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ-WCGFSPCPHGAQCQPVLQGFE 947
Query: 567 CICAPGFTGEECDI 580
CI F G+ I
Sbjct: 948 CIANAVFNGQSGQI 961
Score = 33.5 bits (75), Expect = 0.73
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 470 DFCALSPC-AHGTCRSVGTSYKCLCDPGYHGLYCEEEY 506
D+C PC + G C ++ SY+C C Y G C EY
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREY 711
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/38 (44%), Positives = 19/38 (50%), Gaps = 5/38 (13%)
Query: 96 DPCASNPCH-HGNCSSSSSSSSDGYLCICNEGYEGPNC 132
D C S PC G C + S Y C C+ YEGPNC
Sbjct: 674 DWCESQPCQSRGRCINLWLS----YQCDCHRPYEGPNC 707
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 241 bits (614), Expect = 2e-63
Identities = 123/349 (35%), Positives = 165/349 (47%), Gaps = 46/349 (13%)
Query: 307 CVPG------ESHANDL--ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKP 357
C+PG + + ND +C C + + C C Y G CE + D C P
Sbjct: 438 CLPGWMGQNCDININDCLGQCQNDASCRDLVNG--YRCICPPGYAGDHCERDIDECASNP 495
Query: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
C N C + + + F C+C G++G LCQ IDYC +PC+NGA C + S + C+
Sbjct: 496 CLNGGHC-----QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCK 550
Query: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYV----------------------------DG 449
CPE Y G C D C ++PC+ +C V G
Sbjct: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
Query: 450 VHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNE 508
FTC+C+ GFTG C + I+ C +PC +G TC SYKC+C G+ G YCE N+
Sbjct: 611 GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIND 670
Query: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCI 568
C PC N TCRDLVN + C C +KG C C +C NG TC +G C+
Sbjct: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM 730
Query: 569 CAPGFTGEECDIDIN-ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
C G+ G C+I N C NPCH+GG+C+ + C C GW G C
Sbjct: 731 CPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
Score = 233 bits (594), Expect = 5e-61
Identities = 114/310 (36%), Positives = 171/310 (55%), Gaps = 25/310 (8%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA--NEKQDGSNF 376
CS K P + C C+ + G +C++ C + C+ NE +
Sbjct: 238 CSPKHGSCKLPGD----CRCQYGWQGLYCDK--------CIPHPGCVHGICNEP-----W 280
Query: 377 TCVCLPGYTGELCQSKIDYC-ILDPCRNGATCISS-LSGFTCQCPEGYFGSACEEKVDPC 434
C+C + G+LC ++YC PC NG TC ++ + C CPEGY G CE C
Sbjct: 281 QCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC 340
Query: 435 ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLC 493
S PC N G+C + F C CSPG+TGPTC+ ID C+ + C+HG TC+ + +KC+C
Sbjct: 341 LSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVC 400
Query: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCL 553
P + G C+ + NEC + PC+NA +C++L+ Y C CL + G +C++ + C C
Sbjct: 401 PPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQ 459
Query: 554 NGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
N A+C D +NG CIC PG+ G+ C+ DI+EC SNPC +GG C ++ N + C CP G+
Sbjct: 460 NDASC-RDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFS 518
Query: 613 GANCEIHLQW 622
G C++ + +
Sbjct: 519 GNLCQLDIDY 528
Score = 231 bits (589), Expect = 2e-60
Identities = 122/328 (37%), Positives = 164/328 (50%), Gaps = 34/328 (10%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DACQRKPCQNNASC------------- 364
C +C + S+ + C C E Y G C D C+ PC+ SC
Sbjct: 534 CQNGAQCYNRASD--YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGV 591
Query: 365 --IDAN--------EKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF 414
I +N + Q G FTC C G+TG C I+ C +PCRNG TCI ++ +
Sbjct: 592 RYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSY 651
Query: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL 474
C C +G+ G+ CE ++ C+ +PC N GTC F C+C G+ G TC C
Sbjct: 652 KCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDE 711
Query: 475 SPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNE-CLSAPCLNAATCRDLVNG--YECV 530
+ C +G TC G ++KC+C G+ G C N CL PC N TC +VNG + CV
Sbjct: 712 ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTC--VVNGESFTCV 769
Query: 531 CLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNP 589
C ++G C + C+ C N TC DG N C CAPGF G +C I+INEC S+P
Sbjct: 770 CKEGWEGPICAQNTNDCSPHPCYNSGTC-VDGDNWYRCECAPGFAGPDCRININECQSSP 828
Query: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCE 617
C G +C+D+ NGY C CP G GA C+
Sbjct: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQ 856
Score = 217 bits (552), Expect = 4e-56
Identities = 117/371 (31%), Positives = 164/371 (44%), Gaps = 77/371 (20%)
Query: 319 CSGKGKCT-TKPSEATFSCTCEEQYVGTFCEEYD-ACQRKPCQNNASCIDANEKQDGSNF 376
C G C+ T P + + C+C E Y G CE + AC PC N SC K+ F
Sbjct: 306 CLNGGTCSNTGPDK--YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC-----KETSLGF 358
Query: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS 436
C C PG+TG C + ID C + C +G TC ++GF C CP + G C+ + C +
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDP 495
PC N +C + C+C PG+ G C I+ C L C + +CR + Y+C+C P
Sbjct: 419 KPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPP 477
Query: 496 GYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLA---------------------- 533
GY G +CE + +EC S PCLN C++ +N ++C+C
Sbjct: 478 GYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNG 537
Query: 534 ----------------EYKGTHCELYKDPCANVSCL------------------------ 553
+Y+G +C KD C C
Sbjct: 538 AQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSN 597
Query: 554 ----NGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPH 609
+G G TC C GFTG C +IN+C+SNPC +GG+C+D N Y C C
Sbjct: 598 VCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSD 657
Query: 610 GWVGANCEIHL 620
GW GA CE ++
Sbjct: 658 GWEGAYCETNI 668
Score = 154 bits (388), Expect = 4e-37
Identities = 95/300 (31%), Positives = 136/300 (45%), Gaps = 42/300 (14%)
Query: 311 ESHANDLE---CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA-CQRKPCQNNASCID 366
E++ ND C G C ++ F C C+ + G C D+ C C N +C D
Sbjct: 665 ETNINDCSQNPCHNGGTCRDLVND--FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYD 722
Query: 367 ANEKQDGSNFTCVCLPGYTGELCQ-SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGS 425
+G F C+C G+ G C ++ C+ +PC NG TC+ + FTC C EG+ G
Sbjct: 723 -----EGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGP 777
Query: 426 ACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCR 483
C + + C+ PC N+GTC VDG + + C C+PGF GP C I+ C SPCA G TC
Sbjct: 778 ICAQNTNDCSPHPCYNSGTC-VDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCV 836
Query: 484 SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELY 543
Y+C+C PG+ G C+E V+G C+ + + +
Sbjct: 837 DEINGYRCVCPPGHSGAKCQE-------------------VSGRPCITMGSVIPDGAK-W 876
Query: 544 KDPCANVSCLNGATCDSDGLNG--TCICAPGF----TGEEC-DIDINECDSNPCHHGGSC 596
D C CLNG S G C+ G +G+ C I ++C +PC G C
Sbjct: 877 DDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGEC 936
Score = 152 bits (385), Expect = 8e-37
Identities = 92/291 (31%), Positives = 136/291 (46%), Gaps = 32/291 (10%)
Query: 337 TCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYC 396
TC++ Y G C ++ C+ + D N + C+ G+ G C I
Sbjct: 186 TCDDYYYGFGCNKF--CRPRDDFFGHYACDQNGNK-------TCMEGWMGPECNRAI--- 233
Query: 397 ILDPCRNGATC---ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFT 453
CR G + L G C+C G+ G C D C P +G C +
Sbjct: 234 ----CRQGCSPKHGSCKLPG-DCRCQYGWQGLYC----DKCIPHPGCVHGIC---NEPWQ 281
Query: 454 CNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGTS-YKCLCDPGYHGLYCEEEYNECL 510
C C + G C + +++C PC +G TC + G Y+C C GY G CE + CL
Sbjct: 282 CLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL 341
Query: 511 SAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCIC 569
S PC N +C++ G+EC C + G C D C+ +C +G TC D +NG C+C
Sbjct: 342 SDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ-DLVNGFKCVC 400
Query: 570 APGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
P +TG+ C +D NEC++ PC + SC + Y C C GW+G NC+I++
Sbjct: 401 PPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDINI 451
Score = 119 bits (298), Expect = 1e-26
Identities = 79/296 (26%), Positives = 116/296 (39%), Gaps = 40/296 (13%)
Query: 303 KVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQN 360
K TC +S ++ C+ G C + F C C + GT C +C PC N
Sbjct: 698 KGKTCHSRDSQCDEATCNNGGTCYDEGD--AFKCMCPGGWEGTTCNIARNSSCLPNPCHN 755
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
+C+ +G +FTCVC G+ G +C + C PC N TC+ + + C+C
Sbjct: 756 GGTCV-----VNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAP 810
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI----------- 469
G+ G C ++ C SSPC TC + + C C PG +G C ++
Sbjct: 811 GFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVI 870
Query: 470 -------DFCALSPCAHG--TCRSVGTSYK-CLCDPGYH----GLYCEEEYNE-CLSAPC 514
D C C +G C V + CL G+ G C ++ C PC
Sbjct: 871 PDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPC 930
Query: 515 LNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICA 570
CR + + K T Y+D CAN++ S GL IC+
Sbjct: 931 TGVGECRS-----SSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICS 981
Score = 70.1 bits (170), Expect = 7e-12
Identities = 32/83 (38%), Positives = 44/83 (53%), Gaps = 16/83 (19%)
Query: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-GNCS 109
QPC NGG C++ G Y C+CP G SG NC++ C S+PCH+ G+C
Sbjct: 304 QPCLNGGTCSN-----------TGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK 352
Query: 110 SSSSSSSDGYLCICNEGYEGPNC 132
+S G+ C C+ G+ GP C
Sbjct: 353 ETSL----GFECECSPGWTGPTC 371
Score = 64.7 bits (156), Expect = 3e-10
Identities = 34/86 (39%), Positives = 40/86 (46%), Gaps = 17/86 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG- 106
CA+ PC NGG C + + C CP G SG CQL D C NPC +G
Sbjct: 491 CASNPCLNGGHCQNEINR------------FQCLCPTGFSGNLCQLDIDYCEPNPCQNGA 538
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
C + +S Y C C E YEG NC
Sbjct: 539 QCYNRASD----YFCKCPEDYEGKNC 560
Score = 59.7 bits (143), Expect = 9e-09
Identities = 29/93 (31%), Positives = 38/93 (40%), Gaps = 16/93 (17%)
Query: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP-CASN 101
S C C NGG C + + C CP G G C + + C N
Sbjct: 704 SRDSQCDEATCNNGGTCYDEGD------------AFKCMCPGGWEGTTCNIARNSSCLPN 751
Query: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
PCH+G + S + C+C EG+EGP C Q
Sbjct: 752 PCHNGGTCVVNGES---FTCVCKEGWEGPICAQ 781
Score = 58.9 bits (141), Expect = 2e-08
Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PCRNGG C G Y C C G GA C+ + C+ NPCH+G
Sbjct: 633 CESNPCRNGGTCID------------GVNSYKCICSDGWEGAYCETNINDCSQNPCHNG- 679
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
+ + + C C G++G C
Sbjct: 680 --GTCRDLVNDFYCDCKNGWKGKTC 702
Score = 57.8 bits (138), Expect = 4e-08
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ PC N G C G+ Y C C G +G +C++ + C S+PC G
Sbjct: 786 CSPHPCYNSGTCVD------------GDNWYRCECAPGFAGPDCRININECQSSPCAFG- 832
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
++ +GY C+C G+ G C++
Sbjct: 833 --ATCVDEINGYRCVCPPGHSGAKCQE 857
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 5/58 (8%)
Query: 77 GYSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
GY C CP G +G +C+ D CASNPC + G+C + + + C+C G+ G C+
Sbjct: 470 GYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR----FQCLCPTGFSGNLCQ 523
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG C E ++C C G G C + C+ +PC++
Sbjct: 748 CLPNPCHNGGTCVVNGE------------SFTCVCKEGWEGPICAQNTNDCSPHPCYN-- 793
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
S + + Y C C G+ GP+C
Sbjct: 794 -SGTCVDGDNWYRCECAPGFAGPDC 817
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/115 (25%), Positives = 37/115 (32%), Gaps = 43/115 (37%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
C PC+NG C +R Y C CP G NC + D C + PC
Sbjct: 529 CEPNPCQNGAQCYNRASD------------YFCKCPEDYEGKNCSHLKDHCRTTPCEVID 576
Query: 105 -------------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
HG C S S + C CN+G+ G C +
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK---FTCDCNKGFTGTYCHE 628
Score = 49.7 bits (117), Expect = 1e-05
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
++C C G +G C + C SNPC +G +S Y CIC++G+EG CE
Sbjct: 613 FTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS---YKCICSDGWEGAYCE 665
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/86 (29%), Positives = 36/86 (41%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ C +GG C G+ C CP +G CQL A+ C + PC +
Sbjct: 378 CSPNNCSHGGTCQDLVN------------GFKCVCPPQWTGKTCQLDANECEAKPCVNAK 425
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ +S Y C C G+ G NC+
Sbjct: 426 SCKNLIAS---YYCDCLPGWMGQNCD 448
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/93 (35%), Positives = 41/93 (44%), Gaps = 6/93 (6%)
Query: 45 PGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN-P 102
PG C Q G C P P H EP + C C G C + C ++ P
Sbjct: 248 PGDCRCQYGWQGLYCDKCIPHPGCVHGI-CNEP-WQCLCETNWGGQLCDKDLNYCGTHQP 305
Query: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
C +G + S++ D Y C C EGY GPNCE A
Sbjct: 306 CLNGG--TCSNTGPDKYQCSCPEGYSGPNCEIA 336
Score = 48.5 bits (114), Expect = 2e-05
Identities = 23/86 (26%), Positives = 33/86 (38%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC N G C G+ C C G +G C D C+ N C HG
Sbjct: 340 CLSDPCHNRGSCKET------------SLGFECECSPGWTGPTCSTNIDDCSPNNCSHG- 386
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ +G+ C+C + G C+
Sbjct: 387 --GTCQDLVNGFKCVCPPQWTGKTCQ 410
Score = 40.4 bits (93), Expect = 0.006
Identities = 39/152 (25%), Positives = 57/152 (37%), Gaps = 38/152 (25%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCAS------ 100
C + PC G C GY C CP G SGA CQ V+ PC +
Sbjct: 824 CQSSPCAFGATCVDEIN------------GYRCVCPPGHSGAKCQEVSGRPCITMGSVIP 871
Query: 101 ------NPCHHGNCSSSSSSSSDGYL----CICNEGY-EGPNCEQALPSL-------PAT 142
+ C+ C + + S + C+ ++G+ E P+ + +P L P T
Sbjct: 872 DGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCT 931
Query: 143 GWTESMAPRQLQPVPATQEPDKILPRSQATVT 174
G E + LQPV D + A +T
Sbjct: 932 GVGECRS-SSLQPVKTKCTSDSYYQDNCANIT 962
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 229 bits (583), Expect = 9e-60
Identities = 112/308 (36%), Positives = 158/308 (51%), Gaps = 16/308 (5%)
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDAC-QRKPCQNNASCIDANEKQDGSN 375
EC C + C CE + G C+ + + C PC N +CI+A Q
Sbjct: 275 ECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ---- 330
Query: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
+ C C GY+G C+ C +PC NG +C SGF C CP G+ G C +D CA
Sbjct: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Query: 436 SSPCQNNGTCY--VDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCL 492
S+PC GTC VDG F C C + G TC + C PC + +C+++ Y C
Sbjct: 391 SNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
Query: 493 CDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSC 552
C PG+ G+ C N+C C + TC+DLVNGY+CVC + G HCEL +D CA+ C
Sbjct: 449 CIPGWKGINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 507
Query: 553 LNGATCD--SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHG 610
+G C+ +DG + C C GF+G C++D++ C+ +PC +G C + Y C CP
Sbjct: 508 HSGGLCEDLADGFH--CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
Query: 611 WVGANCEI 618
+ G NC +
Sbjct: 566 FGGKNCSV 573
Score = 223 bits (568), Expect = 5e-58
Identities = 117/343 (34%), Positives = 157/343 (45%), Gaps = 41/343 (11%)
Query: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNN 361
V V C P C +C E + C C + + G C + R+PC
Sbjct: 535 VDVDLCEPSP-------CRNGARCYNL--EGDYYCACPDDFGGKNC----SVPREPCPGG 581
Query: 362 ASCI------DANE------------------KQDGSNFTCVCLPGYTGELCQSKIDYCI 397
A + DA Q G NF+C+C G+TG C ID C+
Sbjct: 582 ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 641
Query: 398 LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS 457
PCRNG TCI + F C CP G+ G C+ + C PC + G CY F C C
Sbjct: 642 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD 701
Query: 458 PGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYN-ECLSAPCL 515
G+ G TC C C++ GTC G +++C C PG+ G C N CL PC+
Sbjct: 702 DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 761
Query: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFT 574
N TC + C+C ++G C + C + C NG C DG+N C CAPGF
Sbjct: 762 NGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC-VDGVNWFRCECAPGFA 820
Query: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
G +C I+I+EC S+PC +G +C+D+ NGY C CP G G C+
Sbjct: 821 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
Score = 204 bits (518), Expect = 3e-52
Identities = 118/387 (30%), Positives = 164/387 (42%), Gaps = 80/387 (20%)
Query: 307 CVPG----ESHANDLECSGKGKC----TTKPSEATFSCTCEEQYVGTFCE-EYDACQRKP 357
C+PG H N +C +G+C T K + C C + G CE E D C P
Sbjct: 449 CIPGWKGINCHINVNDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP 506
Query: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
C + C D + F C C G++G LC+ +D C PCRNGA C + + C
Sbjct: 507 CHSGGLCEDLAD-----GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCA 561
Query: 418 CPEGYFGSACEEKVDPC-----------------------ASSPCQNNGTCYVD-GVHFT 453
CP+ + G C +PC AS C +G C G +F+
Sbjct: 562 CPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFS 621
Query: 454 CNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C GFTG C + ID C PC +G TC +++C C G+ G C+ N+CL
Sbjct: 622 CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD 681
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC------------------------- 547
PC + C DLVN + C C +KG C + C
Sbjct: 682 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 741
Query: 548 ---------ANVSCL-----NGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHG 593
N SCL NG TC G + +CIC G+ G C + N+C+ PC++G
Sbjct: 742 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNG 801
Query: 594 GSCLDQPNGYNCHCPHGWVGANCEIHL 620
G C+D N + C C G+ G +C I++
Sbjct: 802 GICVDGVNWFRCECAPGFAGPDCRINI 828
Score = 199 bits (507), Expect = 6e-51
Identities = 111/371 (29%), Positives = 158/371 (42%), Gaps = 60/371 (16%)
Query: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
TC C+ G C + F C C EQ+VG C+ + + C+ KPC N SC
Sbjct: 381 TCALDIDECASNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDANECEGKPCLNAFSC 438
Query: 365 ---------------------IDANE-----------KQDGSNFTCVCLPGYTGELCQSK 392
I+ N+ K + + CVC G+ G C+ +
Sbjct: 439 KNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE 498
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
D C PC +G C GF C CP+G+ G CE VD C SPC+N CY +
Sbjct: 499 RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDY 558
Query: 453 TCNCSPGFTGPTCA-----------QLIDFC------------ALSPCA-HGTCRS-VGT 487
C C F G C+ ++ID C A C HG C S G
Sbjct: 559 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
Query: 488 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC 547
++ C+CD G+ G YC E ++CL PC N TC D V+ + C C + ++G C+ + C
Sbjct: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
Query: 548 ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHC 607
C + C + C C G+ G+ C +CD+ C +GG+C D + + C C
Sbjct: 679 LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCAC 738
Query: 608 PHGWVGANCEI 618
P GW G+ C +
Sbjct: 739 PPGWKGSTCAV 749
Score = 152 bits (385), Expect = 8e-37
Identities = 92/309 (29%), Positives = 138/309 (44%), Gaps = 39/309 (12%)
Query: 338 CEEQYVGTFCEEYDACQ-RKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYC 396
C+E Y C ++ C+ R + +C K C+ G+ G+ C+ +
Sbjct: 198 CDENYYSATCNKF--CRPRNDFFGHYTCDQYGNK--------ACMDGWMGKECKEAV--- 244
Query: 397 ILDPCRNGATCISSLSGFT----CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
C+ G + G T C+C G+ G C+E C P +G+C +
Sbjct: 245 ----CKQGCNLLHG--GCTVPGECRCSYGWQGRFCDE----CVPYPGCVHGSCVEP---W 291
Query: 453 TCNCSPGFTGPTCAQLIDFCALS-PCAHG-TC-RSVGTSYKCLCDPGYHGLYCEEEYNEC 509
CNC + G C + +++C PC +G TC + Y+C C GY G CE+ + C
Sbjct: 292 QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC 351
Query: 510 LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCIC 569
S PC N +C ++ +G+EC C + + G C L D CA+ C G TC CIC
Sbjct: 352 TSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411
Query: 570 APGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL-----QWKS 624
+ G C +D NEC+ PC + SC + GY C C GW G NC I++ Q +
Sbjct: 412 PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQH 471
Query: 625 GHMAESLTN 633
G + L N
Sbjct: 472 GGTCKDLVN 480
Score = 123 bits (309), Expect = 5e-28
Identities = 94/324 (29%), Positives = 132/324 (40%), Gaps = 46/324 (14%)
Query: 303 KVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQN 360
K TC E + CS G C S TF C C + G+ C + +C PC N
Sbjct: 705 KGKTCHSREFQCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVN 762
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
+C+ + G++F+C+C G+ G C + C PC NG C+ ++ F C+C
Sbjct: 763 GGTCVGS-----GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAP 817
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
G+ G C +D C SSPC TC + + C+C PG GP C ++I F
Sbjct: 818 GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGF-------GR 870
Query: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNA-ATCRDLVNGYECVCLAEYKGTH 539
+C S GT P HG E+ N C CL+ C + G++ LA
Sbjct: 871 SCWSRGT-------PFPHGSSWVEDCNSC---RCLDGRRDCSKVWCGWKPCLLAG----- 915
Query: 540 CELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC-----HHGG 594
+ + C G C + G C+ P EC + E S PC H
Sbjct: 916 ----QPEALSAQCPLGQRC-LEKAPGQCLRPPCEAWGECGAE--EPPSTPCLPRSGHLDN 968
Query: 595 SCLDQPNGYN-CHCPHG-WVGANC 616
+C +N H P G VGA C
Sbjct: 969 NCARLTLHFNRDHVPQGTTVGAIC 992
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/86 (39%), Positives = 42/86 (48%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGG C H P+G + C CP+G SG C L D CASNPC G
Sbjct: 351 CTSNPCANGGSC---------HEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAG- 397
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ DG+ CIC E + G C+
Sbjct: 398 --GTCVDQVDGFECICPEQWVGATCQ 421
Score = 66.6 bits (161), Expect = 8e-11
Identities = 32/86 (37%), Positives = 41/86 (47%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C Q C++GG C GY C CP G G +C+L D CAS+PCH G
Sbjct: 465 CRGQ-CQHGGTCKDLVN------------GYQCVCPRGFGGRHCELERDECASSPCHSGG 511
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+DG+ C C +G+ GP CE
Sbjct: 512 L---CEDLADGFHCHCPQGFSGPLCE 534
Score = 65.9 bits (159), Expect = 1e-10
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 14/81 (17%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
PC NGG C + EPD Y CTCP G SG NC+ C SNPC +G S
Sbjct: 316 PCTNGGTCINA-EPDQ----------YRCTCPDGYSGRNCEKAEHACTSNPCANG---GS 361
Query: 112 SSSSSDGYLCICNEGYEGPNC 132
G+ C C G+ GP C
Sbjct: 362 CHEVPSGFECHCPSGWSGPTC 382
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 15/89 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG+C G + C C G +G +C++ D C S+PC +G
Sbjct: 793 CNPLPCYNGGICVD------------GVNWFRCECAPGFAGPDCRINIDECQSSPCAYG- 839
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
++ +GY C C G GP C++ +
Sbjct: 840 --ATCVDEINGYRCSCPPGRAGPRCQEVI 866
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC +GG+C + G+ C CP G SG C++ D C +PC +G
Sbjct: 502 CASSPCHSGGLCEDLAD------------GFHCHCPQGFSGPLCEVDVDLCEPSPCRNG- 548
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
+ + Y C C + + G NC ++P P G
Sbjct: 549 --ARCYNLEGDYYCACPDDFGGKNC--SVPREPCPG 580
Score = 57.0 bits (136), Expect = 6e-08
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC GG C + + G+ C CP GA CQL A+ C PC +
Sbjct: 389 CASNPCAAGGTCVDQVD------------GFECICPEQWVGATCQLDANECEGKPCLN-- 434
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
+ S + GY C C G++G NC
Sbjct: 435 -AFSCKNLIGGYYCDCIPGWKGINC 458
Score = 55.5 bits (132), Expect = 2e-07
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 17/86 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
C QPCRNGG C + + C CP+G G C + C +PCH G
Sbjct: 640 CLGQPCRNGGTCIDEVD------------AFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
C + + C C++G++G C
Sbjct: 688 RCYDLVND----FYCACDDGWKGKTC 709
Score = 52.4 bits (124), Expect = 2e-06
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
C A C NGG C + + C CP G G+ C + + C NPC +G
Sbjct: 716 CDAYTCSNGGTCYDSGDT------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNG 763
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
S +S + CIC +G+EG C
Sbjct: 764 GTCVGSGAS---FSCICRDGWEGRTC 786
Score = 50.4 bits (119), Expect = 6e-06
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH 104
PG A+ C G C S+P + +SC C +G +G C D C PC
Sbjct: 598 PGTAASGVCGPHGRCVSQPGGN-----------FSCICDSGFTGTYCHENIDDCLGQPCR 646
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+G + D + C C G+EG C+
Sbjct: 647 NG---GTCIDEVDAFRCFCPSGWEGELCD 672
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/111 (25%), Positives = 36/111 (32%), Gaps = 39/111 (35%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
C PCRNG C + E Y C CP G NC + +PC C
Sbjct: 540 CEPSPCRNGARCYNL------------EGDYYCACPDDFGGKNCSVPREPCPGGACRVID 587
Query: 105 ---------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
HG C S + + CIC+ G+ G C +
Sbjct: 588 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN---FSCICDSGFTGTYCHE 635
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 43 SAPGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
+ PG C G C P P H + EP + C C G C + C S+
Sbjct: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCV-EP-WQCNCETNWGGLLCDKDLNYCGSH 314
Query: 102 -PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
PC +G + ++ D Y C C +GY G NCE+A
Sbjct: 315 HPCTNGG--TCINAEPDQYRCTCPDGYSGRNCEKA 347
Score = 43.9 bits (102), Expect = 5e-04
Identities = 23/85 (27%), Positives = 31/85 (36%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG C +SC C G G C + C PC++G
Sbjct: 755 CLPNPCVNGGTCVG------------SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 802
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
+ + C C G+ GP+C
Sbjct: 803 I---CVDGVNWFRCECAPGFAGPDC 824
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 225 bits (573), Expect = 1e-58
Identities = 113/301 (37%), Positives = 162/301 (53%), Gaps = 24/301 (7%)
Query: 323 GKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLP 382
G CT P E C C + G FC+E C P + SC++ + C C
Sbjct: 254 GGCTV-PGE----CRCSYGWQGRFCDE---CVPYPGCVHGSCVEP--------WQCNCET 297
Query: 383 GYTGELCQSKIDYC-ILDPCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPCASSPCQ 440
+ G LC ++YC PC NG TCI++ + C CP+GY G CE+ C S+PC
Sbjct: 298 NWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
Query: 441 NNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHG 499
N G+C+ F C+C G++GPTCA ID CA +PCA G TC ++C+C + G
Sbjct: 358 NGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417
Query: 500 LYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD 559
C+ + N+C C + TC+DLVNGY+CVC + G HCEL +D CA+ C +G C+
Sbjct: 418 ATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCE 476
Query: 560 --SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
+DG + C C GF+G C++D++ C+ +PC +G C + Y C CP + G NC
Sbjct: 477 DLADGFH--CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 534
Query: 618 I 618
+
Sbjct: 535 V 535
Score = 223 bits (568), Expect = 5e-58
Identities = 117/343 (34%), Positives = 157/343 (45%), Gaps = 41/343 (11%)
Query: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNN 361
V V C P C +C E + C C + + G C + R+PC
Sbjct: 497 VDVDLCEPSP-------CRNGARCYNL--EGDYYCACPDDFGGKNC----SVPREPCPGG 543
Query: 362 ASCI------DANE------------------KQDGSNFTCVCLPGYTGELCQSKIDYCI 397
A + DA Q G NF+C+C G+TG C ID C+
Sbjct: 544 ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 603
Query: 398 LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS 457
PCRNG TCI + F C CP G+ G C+ + C PC + G CY F C C
Sbjct: 604 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD 663
Query: 458 PGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYN-ECLSAPCL 515
G+ G TC C C++ GTC G +++C C PG+ G C N CL PC+
Sbjct: 664 DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 723
Query: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFT 574
N TC + C+C ++G C + C + C NG C DG+N C CAPGF
Sbjct: 724 NGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC-VDGVNWFRCECAPGFA 782
Query: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
G +C I+I+EC S+PC +G +C+D+ NGY C CP G G C+
Sbjct: 783 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
Score = 209 bits (532), Expect = 7e-54
Identities = 117/367 (31%), Positives = 159/367 (43%), Gaps = 74/367 (20%)
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDAC-QRKPCQNNASCIDANEKQDGSN 375
EC C + C CE + G C+ + + C PC N +CI+A Q
Sbjct: 275 ECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ---- 330
Query: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
+ C C GY+G C+ C +PC NG +C SGF C CP G+ G C +D CA
Sbjct: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Query: 436 SSPCQNNGTC--YVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCL 492
S+PC GTC VDG F C C + G TC ++ C C H GTC+ + Y+C+
Sbjct: 391 SNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCV 447
Query: 493 CDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSC 552
C G+ G +CE E +EC S+PC + C DL +G+ C C + G CE+ D C C
Sbjct: 448 CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 507
Query: 553 LNGATC-------------DSDGLN----------GTC---------------------I 568
NGA C D G N G C +
Sbjct: 508 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGV 567
Query: 569 CAP------------------GFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHG 610
C P GFTG C +I++C PC +GG+C+D+ + + C CP G
Sbjct: 568 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 627
Query: 611 WVGANCE 617
W G C+
Sbjct: 628 WEGELCD 634
Score = 199 bits (505), Expect = 1e-50
Identities = 112/368 (30%), Positives = 155/368 (42%), Gaps = 72/368 (19%)
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNF 376
+C G C K + C C + G CE E D C PC + C D + F
Sbjct: 430 QCQHGGTC--KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD-----GF 482
Query: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC-- 434
C C G++G LC+ +D C PCRNGA C + + C CP+ + G C +PC
Sbjct: 483 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPG 542
Query: 435 ---------------------ASSPCQNNGTCYVD-GVHFTCNCSPGFTGPTCAQLIDFC 472
AS C +G C G +F+C C GFTG C + ID C
Sbjct: 543 GACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 602
Query: 473 ALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531
PC +G TC +++C C G+ G C+ N+CL PC + C DLVN + C C
Sbjct: 603 LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCAC 662
Query: 532 LAEYKGTHCELYKDPC----------------------------------ANVSCL---- 553
+KG C + C N SCL
Sbjct: 663 DDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPC 722
Query: 554 -NGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
NG TC G + +CIC G+ G C + N+C+ PC++GG C+D N + C C G+
Sbjct: 723 VNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA 782
Query: 613 GANCEIHL 620
G +C I++
Sbjct: 783 GPDCRINI 790
Score = 123 bits (309), Expect = 5e-28
Identities = 94/324 (29%), Positives = 132/324 (40%), Gaps = 46/324 (14%)
Query: 303 KVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQN 360
K TC E + CS G C S TF C C + G+ C + +C PC N
Sbjct: 667 KGKTCHSREFQCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVN 724
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
+C+ + G++F+C+C G+ G C + C PC NG C+ ++ F C+C
Sbjct: 725 GGTCVGS-----GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAP 779
Query: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
G+ G C +D C SSPC TC + + C+C PG GP C ++I F
Sbjct: 780 GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGF-------GR 832
Query: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNA-ATCRDLVNGYECVCLAEYKGTH 539
+C S GT P HG E+ N C CL+ C + G++ LA
Sbjct: 833 SCWSRGT-------PFPHGSSWVEDCNSC---RCLDGRRDCSKVWCGWKPCLLAG----- 877
Query: 540 CELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC-----HHGG 594
+ + C G C + G C+ P EC + E S PC H
Sbjct: 878 ----QPEALSAQCPLGQRC-LEKAPGQCLRPPCEAWGECGAE--EPPSTPCLPRSGHLDN 930
Query: 595 SCLDQPNGYN-CHCPHG-WVGANC 616
+C +N H P G VGA C
Sbjct: 931 NCARLTLHFNRDHVPQGTTVGAIC 954
Score = 105 bits (263), Expect = 1e-22
Identities = 62/214 (28%), Positives = 99/214 (46%), Gaps = 34/214 (15%)
Query: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCN------CSPGFTGPTCAQLI- 469
+C E Y+ + C + C+ + H+TC+ C G+ G C + +
Sbjct: 197 RCDENYYSATCNKF--------CRPRNDFFG---HYTCDQYGNKACMDGWMGKECKEAVC 245
Query: 470 -DFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYE 528
C L HG C G +C C G+ G +C+E C+ P +C V ++
Sbjct: 246 KQGCNL---LHGGCTVPG---ECRCSYGWQGRFCDE----CVPYPGCVHGSC---VEPWQ 292
Query: 529 CVCLAEYKGTHCELYKDPC-ANVSCLNGATC-DSDGLNGTCICAPGFTGEECDIDINECD 586
C C + G C+ + C ++ C NG TC +++ C C G++G C+ + C
Sbjct: 293 CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACT 352
Query: 587 SNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
SNPC +GGSC + P+G+ CHCP GW G C + +
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/86 (39%), Positives = 42/86 (48%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGG C H P+G + C CP+G SG C L D CASNPC G
Sbjct: 351 CTSNPCANGGSC---------HEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAG- 397
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ DG+ CIC E + G C+
Sbjct: 398 --GTCVDQVDGFECICPEQWVGATCQ 421
Score = 67.4 bits (163), Expect = 5e-11
Identities = 36/111 (32%), Positives = 48/111 (43%), Gaps = 28/111 (25%)
Query: 48 CAAQPCRNGGVCTSRPE------PDP-----------------QHPAPAGE--PGYSCTC 82
CA+ PC GG C + + P+ QH + GY C C
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVC 448
Query: 83 PAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
P G G +C+L D CAS+PCH G +DG+ C C +G+ GP CE
Sbjct: 449 PRGFGGRHCELERDECASSPCHSGGL---CEDLADGFHCHCPQGFSGPLCE 496
Score = 65.9 bits (159), Expect = 1e-10
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 14/81 (17%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
PC NGG C + EPD Y CTCP G SG NC+ C SNPC +G S
Sbjct: 316 PCTNGGTCINA-EPDQ----------YRCTCPDGYSGRNCEKAEHACTSNPCANG---GS 361
Query: 112 SSSSSDGYLCICNEGYEGPNC 132
G+ C C G+ GP C
Sbjct: 362 CHEVPSGFECHCPSGWSGPTC 382
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 15/89 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG+C G + C C G +G +C++ D C S+PC +G
Sbjct: 755 CNPLPCYNGGICVD------------GVNWFRCECAPGFAGPDCRINIDECQSSPCAYG- 801
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
++ +GY C C G GP C++ +
Sbjct: 802 --ATCVDEINGYRCSCPPGRAGPRCQEVI 828
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC +GG+C + G+ C CP G SG C++ D C +PC +G
Sbjct: 464 CASSPCHSGGLCEDLAD------------GFHCHCPQGFSGPLCEVDVDLCEPSPCRNG- 510
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
+ + Y C C + + G NC ++P P G
Sbjct: 511 --ARCYNLEGDYYCACPDDFGGKNC--SVPREPCPG 542
Score = 55.5 bits (132), Expect = 2e-07
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 17/86 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
C QPCRNGG C + + C CP+G G C + C +PCH G
Sbjct: 602 CLGQPCRNGGTCIDEVD------------AFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 649
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
C + + C C++G++G C
Sbjct: 650 RCYDLVND----FYCACDDGWKGKTC 671
Score = 52.4 bits (124), Expect = 2e-06
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
C A C NGG C + + C CP G G+ C + + C NPC +G
Sbjct: 678 CDAYTCSNGGTCYDSGDT------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNG 725
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
S +S + CIC +G+EG C
Sbjct: 726 GTCVGSGAS---FSCICRDGWEGRTC 748
Score = 50.4 bits (119), Expect = 6e-06
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH 104
PG A+ C G C S+P + +SC C +G +G C D C PC
Sbjct: 560 PGTAASGVCGPHGRCVSQPGGN-----------FSCICDSGFTGTYCHENIDDCLGQPCR 608
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+G + D + C C G+EG C+
Sbjct: 609 NG---GTCIDEVDAFRCFCPSGWEGELCD 634
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/111 (25%), Positives = 36/111 (32%), Gaps = 39/111 (35%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
C PCRNG C + E Y C CP G NC + +PC C
Sbjct: 502 CEPSPCRNGARCYNL------------EGDYYCACPDDFGGKNCSVPREPCPGGACRVID 549
Query: 105 ---------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
HG C S + + CIC+ G+ G C +
Sbjct: 550 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN---FSCICDSGFTGTYCHE 597
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 43 SAPGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
+ PG C G C P P H + EP + C C G C + C S+
Sbjct: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCV-EP-WQCNCETNWGGLLCDKDLNYCGSH 314
Query: 102 -PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
PC +G + ++ D Y C C +GY G NCE+A
Sbjct: 315 HPCTNGG--TCINAEPDQYRCTCPDGYSGRNCEKA 347
Score = 43.9 bits (102), Expect = 5e-04
Identities = 23/85 (27%), Positives = 31/85 (36%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC NGG C +SC C G G C + C PC++G
Sbjct: 717 CLPNPCVNGGTCVG------------SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 764
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
+ + C C G+ GP+C
Sbjct: 765 I---CVDGVNWFRCECAPGFAGPDC 786
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/135 (28%), Positives = 50/135 (37%), Gaps = 28/135 (20%)
Query: 502 CEEEYNECLSAPCLNAATCR-DLVNGYEC------VCLAEYKGTHCELYKDPCANVSCLN 554
C+E Y SA C R D Y C C+ + G C+ C
Sbjct: 198 CDENY---YSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECK-------EAVCKQ 247
Query: 555 GATCDSDGLN--GTCICAPGFTGEECDIDINECDSNP-CHHGGSCLDQPNGYNCHCPHGW 611
G G G C C+ G+ G CD EC P C HG SC++ + C+C W
Sbjct: 248 GCNLLHGGCTVPGECRCSYGWQGRFCD----ECVPYPGCVHG-SCVEP---WQCNCETNW 299
Query: 612 VGANCEIHLQWKSGH 626
G C+ L + H
Sbjct: 300 GGLLCDKDLNYCGSH 314
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 224 bits (572), Expect = 2e-58
Identities = 126/359 (35%), Positives = 176/359 (49%), Gaps = 31/359 (8%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCID 366
C+PG C + KP E C C + G +C+E C R P C+
Sbjct: 226 CLPG--------CDEQHGFCDKPGE----CKCRVGWQGRYCDE---CIRYP-----GCLH 265
Query: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD-PCRNGATCISSLSG-FTCQCPEGYFG 424
+Q + C C G+ G C ++YC PC+NGATC ++ G +TC C GY G
Sbjct: 266 GTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
Query: 425 SACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG--TC 482
+ CE +D C SPC+N G+C ++C C PGF G C CA PC +G
Sbjct: 323 ATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCS 382
Query: 483 RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCEL 542
S Y C C GY G CE++ + C S+PC N A C DL + Y C C A + G HC+
Sbjct: 383 DSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDD 442
Query: 543 YKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPN 601
D CA+ C NG TC DG+N +C C PG+TG C ++ C+ PCH+G +C ++ +
Sbjct: 443 NVDDCASSPCANGGTC-RDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGH 501
Query: 602 GYNCHCPHGWVGANCEIHL-QWKSGHMAESLT-NMPRHSLYIIIGALCVAFILMLIILI 658
Y C C G+ G NC+ L + G LT + A+C IL+L++L+
Sbjct: 502 RYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLL 560
Score = 160 bits (405), Expect = 4e-39
Identities = 80/202 (39%), Positives = 105/202 (51%), Gaps = 10/202 (4%)
Query: 305 STCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNAS 363
+TC G + C G CT E ++SCTC + G CE C PC N
Sbjct: 323 ATCELGIDECDPSPCKNGGSCT--DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGR 380
Query: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
C D+ + ++C C GY+G C+ KIDYC PC NGA C+ + C+C G+
Sbjct: 381 CSDSPD----GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS 436
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-T 481
G C++ VD CASSPC N GTC DGV+ F+C C PG+TG C+ + C +PC +G T
Sbjct: 437 GRHCDDNVDDCASSPCANGGTCR-DGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGAT 495
Query: 482 CRSVGTSYKCLCDPGYHGLYCE 503
C G Y C C GY G C+
Sbjct: 496 CHERGHRYVCECARGYGGPNCQ 517
Score = 100 bits (248), Expect = 6e-21
Identities = 62/196 (31%), Positives = 85/196 (43%), Gaps = 42/196 (21%)
Query: 456 CSPGFTGPTCAQLIDFCALSPCAHG--TCRSVGTSYKCLCDPGYHGLYCEEEY------- 506
C + G C+ FC A G TC G +C+PG+ G YC E
Sbjct: 179 CDEHYYGEGCSV---FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPICLPGCDE 232
Query: 507 ----------------------NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK 544
+EC+ P TC+ ++C C + G C
Sbjct: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQ---QPWQCNCQEGWGGLFCNQDL 289
Query: 545 DPCA-NVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
+ C + C NGATC + G TC C PG+TG C++ I+ECD +PC +GGSC D N
Sbjct: 290 NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS 349
Query: 603 YNCHCPHGWVGANCEI 618
Y+C CP G+ G CE+
Sbjct: 350 YSCTCPPGFYGKICEL 365
Score = 77.0 bits (188), Expect = 6e-14
Identities = 36/93 (38%), Positives = 44/93 (47%), Gaps = 15/93 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA+ PC NGG C G +SCTCP G +G NC C PCH+G
Sbjct: 447 CASSPCANGGTCRD------------GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNG- 493
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
++ Y+C C GY GPNC+ LP LP
Sbjct: 494 --ATCHERGHRYVCECARGYGGPNCQFLLPELP 524
Score = 72.4 bits (176), Expect = 1e-12
Identities = 37/89 (41%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC+NGG CT E YSCTCP G G C+L A CA PC +G
Sbjct: 332 CDPSPCKNGGSCTDL------------ENSYSCTCPPGFYGKICELSAMTCADGPCFNG- 378
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
S S GY C C GY G NCE+ +
Sbjct: 379 -GRCSDSPDGGYSCRCPVGYSGFNCEKKI 406
Score = 72.0 bits (175), Expect = 2e-12
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 14/86 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA PC NGG C+ P+ GYSC CP G SG NC+ D C+S+PC +G
Sbjct: 370 CADGPCFNGGRCSDSPDG-----------GYSCRCPVGYSGFNCEKKIDYCSSSPCSNG- 417
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ D YLC C G+ G +C+
Sbjct: 418 --AKCVDLGDAYLCRCQAGFSGRHCD 441
Score = 60.8 bits (146), Expect = 4e-09
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 14/83 (16%)
Query: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSS 110
+PC+NG CT+ G+ Y+C+C G +GA C+L D C +PC +G
Sbjct: 296 KPCKNGATCTN-----------TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNG---G 341
Query: 111 SSSSSSDGYLCICNEGYEGPNCE 133
S + + Y C C G+ G CE
Sbjct: 342 SCTDLENSYSCTCPPGFYGKICE 364
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/165 (24%), Positives = 56/165 (33%), Gaps = 61/165 (36%)
Query: 515 LNAATCRDLVNGYECVCLAEYKGTHCELYKDP--------------------------CA 548
L+++ DL Y VC Y G C ++ P C
Sbjct: 163 LHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCT 222
Query: 549 NVSCLNGAT-----CDSDG----------------------LNGT------CICAPGFTG 575
CL G CD G L+GT C C G+ G
Sbjct: 223 EPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGG 282
Query: 576 EECDIDINECDSN-PCHHGGSCLDQPNG-YNCHCPHGWVGANCEI 618
C+ D+N C + PC +G +C + G Y C C G+ GA CE+
Sbjct: 283 LFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCEL 327
Score = 38.5 bits (88), Expect = 0.023
Identities = 35/111 (31%), Positives = 41/111 (36%), Gaps = 27/111 (24%)
Query: 27 GPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGI 86
G RG + NP GP +P +C P D QH +PG C C G
Sbjct: 205 GERGEKVCNP------GWKGPYCTEP-----ICL--PGCDEQHGF-CDKPG-ECKCRVGW 249
Query: 87 SGANCQLVADPCASNP-CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
G C D C P C HG C + C C EG+ G C Q L
Sbjct: 250 QGRYC----DECIRYPGCLHGTCQQP-------WQCNCQEGWGGLFCNQDL 289
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 224 bits (570), Expect = 3e-58
Identities = 110/292 (37%), Positives = 149/292 (51%), Gaps = 13/292 (4%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDAC-QRKPCQNNASC 364
C PG EC C + CTC+E + G FC++ + C PC+N A+C
Sbjct: 241 CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC 300
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG 424
++ ++ ++TC C PGYTG C+ ++ C +PCRNG +C G+ C CP GY+G
Sbjct: 301 SNSGQR----SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYG 356
Query: 425 SACEEKVDPCASSPCQNNGTCYV--DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-T 481
CE CA SPC N G+C G ++ C C P FTG C + +D C +PCA+G
Sbjct: 357 LHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQ 416
Query: 482 CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
C + G S C C PG+ G YCE ++C PC + TC DL NG C C A + G CE
Sbjct: 417 CLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
Query: 542 LYK--DPCANVSCLNGATCDSDGLNGT--CICAPGFTGEECDIDINECDSNP 589
+ D CA+ C N ATC +D T C C GF G C+ + S P
Sbjct: 477 VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
Score = 211 bits (538), Expect = 1e-54
Identities = 118/366 (32%), Positives = 171/366 (46%), Gaps = 46/366 (12%)
Query: 268 VLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVST----------CVPGESHANDL 317
+ ++ LA+G N + D T ++ LR + V S C H
Sbjct: 143 IAIQGSLAVGQNWLL----DEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHY 198
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFT 377
C G + P + G +C++ C + N C E
Sbjct: 199 VCQPDGNLSCLPG-----------WTGEYCQQ-PICLSGCHEQNGYCSKPAE-------- 238
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS- 436
C+C PG+ G LC I + + CR+G TC + + C C EG+ G C++ ++ C
Sbjct: 239 CLCRPGWQGRLCNECIPH---NGCRHG-TCSTP---WQCTCDEGWGGLFCDQDLNYCTHH 291
Query: 437 SPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCD 494
SPC+N TC G +TC C PG+TG C + C +PC +G +C+ Y CLC
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNG--YECVCLAEYKGTHCELYKDPCANVSC 552
PGY+GL+CE C +PC N +CR+ G Y C C + G++CE D C + C
Sbjct: 352 PGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411
Query: 553 LNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
NG C + G + C C PGFTG C++ +++C NPC HGG+C D NG C CP G+
Sbjct: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFS 471
Query: 613 GANCEI 618
G CE+
Sbjct: 472 GRRCEV 477
Score = 181 bits (459), Expect = 2e-45
Identities = 104/293 (35%), Positives = 138/293 (47%), Gaps = 26/293 (8%)
Query: 333 TFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
++ C + Y G D C R C+ Q N +C LPG+TGE CQ
Sbjct: 170 SYRVICSDNYYG------DNCSRL-CKKRNDHFGHYVCQPDGNLSC--LPGWTGEYCQQP 220
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
I C+ C C C G+ G C E C +GTC +
Sbjct: 221 I--CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIPHNGCRHGTC---STPW 268
Query: 453 TCNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGT-SYKCLCDPGYHGLYCEEEYNEC 509
C C G+ G C Q +++C SPC +G TC + G SY C C PGY G+ CE E +EC
Sbjct: 269 QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC 328
Query: 510 LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD--SDGLNGTC 567
S PC N +C+D +GY C+C Y G HCE CA+ C NG +C + G N C
Sbjct: 329 DSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYAC 388
Query: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
C P FTG C+ ++ C SNPC +GG CL++ C C G+ G CE+H+
Sbjct: 389 ECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV 441
Score = 80.1 bits (196), Expect = 7e-15
Identities = 47/140 (33%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 305 STCVPGESHANDLECSGKGKCTTK-PSEATFSCTCEEQYVGTFCEEYDA-CQRKPCQNNA 362
S C C+ G+C + PS C C + GT+CE + + C R PC +
Sbjct: 397 SNCEKKVDRCTSNPCANGGQCLNRGPSRM---CRCRPGFTGTYCELHVSDCARNPCAHGG 453
Query: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQ--SKIDYCILDPCRNGATCISSLSG--FTCQC 418
+C D + C C G++G C+ + ID C PC N ATC + LS F C C
Sbjct: 454 TCHDLE-----NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNC 508
Query: 419 PEGYFGSACEEKVDPCASSP 438
P G+ GS CE V S P
Sbjct: 509 PYGFVGSRCEFPVGLPPSFP 528
Score = 70.1 bits (170), Expect = 7e-12
Identities = 31/84 (36%), Positives = 44/84 (52%), Gaps = 14/84 (16%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
PC+NG C++ +G+ Y+CTC G +G +C+L C SNPC +G S
Sbjct: 293 PCKNGATCSN-----------SGQRSYTCTCRPGYTGVDCELELSECDSNPCRNG---GS 338
Query: 112 SSSSSDGYLCICNEGYEGPNCEQA 135
DGY C+C GY G +CE +
Sbjct: 339 CKDQEDGYHCLCPPGYYGLHCEHS 362
Score = 63.5 bits (153), Expect = 7e-10
Identities = 34/99 (34%), Positives = 47/99 (47%), Gaps = 15/99 (15%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL--VADPCASNPCHH 105
CA PC +GG C E G CTCPAG SG C++ D CAS+PC +
Sbjct: 444 CARNPCAHGGTCHDL------------ENGLMCTCPAGFSGRRCEVRTSIDACASSPCFN 491
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGW 144
+ + S+D ++C C G+ G CE + P+ W
Sbjct: 492 -RATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPW 529
Score = 62.4 bits (150), Expect = 1e-09
Identities = 30/87 (34%), Positives = 39/87 (44%), Gaps = 13/87 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PCRNGG C + E GY C CP G G +C+ CA +PC +G
Sbjct: 328 CDSNPCRNGGSCKDQ------------EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGG 375
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
S + Y C C + G NCE+
Sbjct: 376 -SCRERNQGANYACECPPNFTGSNCEK 401
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/87 (35%), Positives = 40/87 (45%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
CA PC NGG C R + Y+C CP +G+NC+ D C SNPC + G
Sbjct: 366 CADSPCFNGGSCRERNQG----------ANYACECPPNFTGSNCEKKVDRCTSNPCANGG 415
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + S +C C G+ G CE
Sbjct: 416 QCLNRGPSR----MCRCRPGFTGTYCE 438
Score = 61.6 bits (148), Expect = 2e-09
Identities = 29/86 (33%), Positives = 37/86 (43%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NGG C +R P C C G +G C+L CA NPC HG
Sbjct: 406 CTSNPCANGGQCLNRG------------PSRMCRCRPGFTGTYCELHVSDCARNPCAHG- 452
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ +G +C C G+ G CE
Sbjct: 453 --GTCHDLENGLMCTCPAGFSGRRCE 476
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 8/97 (8%)
Query: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP 102
S P C +P G +C + P + CTC G G C + C
Sbjct: 234 SKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTP-WQCTCDEGWGGLFCDQDLNYCT--- 289
Query: 103 CHHGNCSSSSSSSSDG---YLCICNEGYEGPNCEQAL 136
HH C + ++ S+ G Y C C GY G +CE L
Sbjct: 290 -HHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL 325
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/125 (30%), Positives = 49/125 (39%), Gaps = 26/125 (20%)
Query: 520 CRDLVNGYECVCLAEYKGTHCELYK-DPCANVSCLNGATCD----------SDGLNG--- 565
C D G C L + + H Y P N+SCL G T + NG
Sbjct: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCS 234
Query: 566 ---TCICAPGFTGEECDIDINEC-DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQ 621
C+C PG+ G C NEC N C HG +C + C C GW G C+ L
Sbjct: 235 KPAECLCRPGWQGRLC----NECIPHNGCRHG-TC---STPWQCTCDEGWGGLFCDQDLN 286
Query: 622 WKSGH 626
+ + H
Sbjct: 287 YCTHH 291
Score = 33.5 bits (75), Expect = 0.73
Identities = 18/65 (27%), Positives = 30/65 (46%), Gaps = 12/65 (18%)
Query: 75 EPGYSCTCPAGISGANCQLVADPCASNPCH--HGNCSSSSSSSSDGYLCICNEGYEGPNC 132
+P + +C G +G CQ P + CH +G CS + C+C G++G C
Sbjct: 201 QPDGNLSCLPGWTGEYCQ---QPICLSGCHEQNGYCSKPAE-------CLCRPGWQGRLC 250
Query: 133 EQALP 137
+ +P
Sbjct: 251 NECIP 255
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 224 bits (570), Expect = 3e-58
Identities = 99/232 (42%), Positives = 126/232 (54%), Gaps = 1/232 (0%)
Query: 387 ELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCY 446
E+ C +PC N TC G+ C CP GY G CE +D C+ PC NNG C
Sbjct: 1188 EISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCK 1247
Query: 447 VDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEE 505
F C C G+TG C + I+ C+ SPC + G C Y+C C G+ GL+CE E
Sbjct: 1248 DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETE 1307
Query: 506 YNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG 565
NEC S PCLN A C D V G+ C C + GT C D C + C NGATC +
Sbjct: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
Query: 566 TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
C+CA GFTG C+++INEC SNPC + +C+D+ N Y+C C G+ G CE
Sbjct: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 200 bits (509), Expect = 3e-51
Identities = 92/234 (39%), Positives = 128/234 (54%), Gaps = 8/234 (3%)
Query: 350 YDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCIS 409
+ C PC N+ +C +Q G + C+C GYTG C++ ID C PC N C
Sbjct: 1194 FHECFFNPCHNSGTC-----QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKD 1248
Query: 410 SLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQL 468
+ F C+CP GY G CEE ++ C+SSPC N G C VDGV + C C GF G C
Sbjct: 1249 LVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCETE 1307
Query: 469 IDFCALSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGY 527
++ C +PC + C + C C PG+ G C + +ECLS PC N ATC+D N +
Sbjct: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
Query: 528 ECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDID 581
C+C A + G+HCEL + C + C N ATC + + +C C PGF+G+ C+ +
Sbjct: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 178 bits (452), Expect = 1e-44
Identities = 106/341 (31%), Positives = 152/341 (44%), Gaps = 53/341 (15%)
Query: 325 CTTKPSEATFSC----TCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVC 380
C + + T+S TCE +GT+ ++ + C N S + K+ N +
Sbjct: 1052 CKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTV----KRGAVNISACG 1107
Query: 381 LPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG---------------- 424
+P G+ +S + C PC ++ F CP ++G
Sbjct: 1108 VPCPEGKFSRSGLMPC--HPCPRDYYQPNAGKAFCLACP--FYGTTPFAGSRSITECSSF 1163
Query: 425 ----SACEEKVDPCAS--------------------SPCQNNGTCYVDGVHFTCNCSPGF 460
SA EE V P AS +PC N+GTC G + C C G+
Sbjct: 1164 SSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGY 1223
Query: 461 TGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAAT 519
TG C ID C+ PC + G C+ + + C C GY G CEE NEC S+PCLN
Sbjct: 1224 TGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGI 1283
Query: 520 CRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECD 579
C D V GY C C+ + G HCE + C + CLN A C+ C C PGF G C
Sbjct: 1284 CVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCG 1343
Query: 580 IDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
+++EC S PC +G +C D N + C C G+ G++CE+++
Sbjct: 1344 KNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNI 1384
Score = 150 bits (380), Expect = 3e-36
Identities = 72/201 (35%), Positives = 96/201 (47%), Gaps = 9/201 (4%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCI 365
C + L C G C E F C C Y G CEE + C PC N C+
Sbjct: 1228 CETDIDECSPLPCLNNGVCKDLVGE--FICECPSGYTGQRCEENINECSSSPCLNKGICV 1285
Query: 366 DANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGS 425
D + + C C+ G+ G C+++++ C +PC N A C + GF C+CP G+ G+
Sbjct: 1286 DGV-----AGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGT 1340
Query: 426 ACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRS 484
C + VD C S PC+N TC F C C+ GFTG C I+ C +PC + TC
Sbjct: 1341 RCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVD 1400
Query: 485 VGTSYKCLCDPGYHGLYCEEE 505
SY C C PG+ G CE E
Sbjct: 1401 ELNSYSCKCQPGFSGKRCETE 1421
Score = 63.2 bits (152), Expect = 9e-10
Identities = 38/104 (36%), Positives = 48/104 (46%), Gaps = 15/104 (14%)
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
PC N C+ C C + G CE +P + CLNG C + C C PG
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRCVAPY---QCDCPPG 3525
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
+TG C + C S PC +GG C+ +PN CHC W G NC
Sbjct: 3526 WTGSRCHTAV--CQS-PCLNGGKCV-RPN--RCHCLSSWTGHNC 3563
Score = 60.8 bits (146), Expect = 4e-09
Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +QPC+NG C G + C C AG +G++C+L + C SNPC +
Sbjct: 1349 CLSQPCKNGATCKD------------GANSFRCLCAAGFTGSHCELNINECQSNPCRN-- 1394
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
++ + Y C C G+ G CE
Sbjct: 1395 -QATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/101 (34%), Positives = 44/101 (43%), Gaps = 21/101 (20%)
Query: 400 PCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPG 459
PC+NG C + C CPEG+ G CEE P PC N G C + C+C PG
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEE---PICILPCLNGGRCVAP---YQCDCPPG 3525
Query: 460 FTGPTCAQLIDFCALSPCAHG---------TCRSVGTSYKC 491
+TG C + SPC +G C S T + C
Sbjct: 3526 WTGSRCHTAV---CQSPCLNGGKCVRPNRCHCLSSWTGHNC 3563
Score = 57.0 bits (136), Expect = 6e-08
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 15/85 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C++ PC N G+C G GY CTC G G +C+ + C SNPC +
Sbjct: 1273 CSSSPCLNKGICVD------------GVAGYRCTCVKGFVGLHCETEVNECQSNPCLN-- 1318
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
++ G+LC C G+ G C
Sbjct: 1319 -NAVCEDQVGGFLCKCPPGFLGTRC 1342
Score = 56.6 bits (135), Expect = 8e-08
Identities = 37/103 (35%), Positives = 48/103 (46%), Gaps = 14/103 (13%)
Query: 438 PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497
PCQN G C C+C G+ G C + I C L PC +G R V Y+C C PG+
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CIL-PCLNGG-RCVAP-YQCDCPPGW 3526
Query: 498 HGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540
G C + +PCLN C V C CL+ + G +C
Sbjct: 3527 TGSRC---HTAVCQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 55.1 bits (131), Expect = 2e-07
Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC N VC + G+ C CP G G C D C S PC +G
Sbjct: 1311 CQSNPCLNNAVCEDQVG------------GFLCKCPPGFLGTRCGKNVDECLSQPCKNG- 1357
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
++ ++ + C+C G+ G +CE
Sbjct: 1358 --ATCKDGANSFRCLCAAGFTGSHCE 1381
Score = 53.1 bits (126), Expect = 9e-07
Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 17/88 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C PC N G C GY C CP G +G C+ D C+ PC ++G
Sbjct: 1197 CFFNPCHNSGTCQQLGR------------GYVCLCPLGYTGLKCETDIDECSPLPCLNNG 1244
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C ++C C GY G CE+
Sbjct: 1245 VCKDLVGE----FICECPSGYTGQRCEE 1268
Score = 52.8 bits (125), Expect = 1e-06
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C+ PC N GVC GE + C CP+G +G C+ + C+S+PC + G
Sbjct: 1235 CSPLPCLNNGVCKDL----------VGE--FICECPSGYTGQRCEENINECSSSPCLNKG 1282
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + GY C C +G+ G +CE
Sbjct: 1283 ICVDGVA----GYRCTCVKGFVGLHCE 1305
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/112 (28%), Positives = 46/112 (41%), Gaps = 21/112 (18%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C G C +P+ +C+C E ++G CEE PC N C+ + + C
Sbjct: 3476 CQNGGICQ-RPN----ACSCPEGWMGRLCEEPICIL--PCLNGGRCV--------APYQC 3520
Query: 379 VCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEK 430
C PG+TG C + + PC NG C+ C C + G C K
Sbjct: 3521 DCPPGWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNCSRK 3566
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 13/112 (11%)
Query: 505 EYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLN 564
+Y + ++ C + + VCL T + + C C NG C
Sbjct: 3433 QYGDMITYSCYSGYMLEGFLRS---VCLENGTWTSPPICRAVC-RFPCQNGGICQRPN-- 3486
Query: 565 GTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
C C G+ G C+ I PC +GG C+ Y C CP GW G+ C
Sbjct: 3487 -ACSCPEGWMGRLCEEPICIL---PCLNGGRCVAP---YQCDCPPGWTGSRC 3531
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 26/102 (25%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHGNCSS 110
PC+NGG+C RP +C+CP G G C+ +P PC + G C +
Sbjct: 3475 PCQNGGIC-QRPN--------------ACSCPEGWMGRLCE---EPICILPCLNGGRCVA 3516
Query: 111 SSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQ 152
Y C C G+ G C A+ P + + P +
Sbjct: 3517 P-------YQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNR 3551
Score = 38.5 bits (88), Expect = 0.023
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 13/140 (9%)
Query: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCP---EGYF 423
+ + + GS C PG+ +L + + YC+ + +C P E F
Sbjct: 1645 SEDLKPGSKVNLFCDPGF--QLVGNPVQYCLNQG--QWTQPLPHCERISCGVPPPLENGF 1700
Query: 424 GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTG--PTCAQLIDFCAL-SPCA-H 479
SA + + C NNG + C + + G P+C +D CA+ S C+ H
Sbjct: 1701 HSADDFYAGSTVTYQC-NNGYYLLGDSRMFCTDNGSWNGVSPSCLD-VDECAVGSDCSEH 1758
Query: 480 GTCRSVGTSYKCLCDPGYHG 499
+C +V SY C C P Y G
Sbjct: 1759 ASCLNVDGSYICSCVPPYTG 1778
Score = 36.6 bits (83), Expect = 0.086
Identities = 15/29 (51%), Positives = 18/29 (62%), Gaps = 3/29 (10%)
Query: 589 PCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
PC +GG C +PN C CP GW+G CE
Sbjct: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCE 3500
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 24/88 (27%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106
P PC NGG C AP Y C CP G +G+ C C S + G
Sbjct: 3502 PICILPCLNGGRCV----------AP-----YQCDCPPGWTGSRCHTAV--CQSPCLNGG 3544
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C + C C + G NC +
Sbjct: 3545 KCVRPNR-------CHCLSSWTGHNCSR 3565
Score = 35.8 bits (81), Expect = 0.15
Identities = 52/217 (23%), Positives = 62/217 (28%), Gaps = 72/217 (33%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
C G C F C CE+ Y G G + C
Sbjct: 288 CDRMGSCKCGTHTGHFECICEKGYYGK---------------------------GLQYEC 320
Query: 379 VCLPG--YTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY--FGSACEEKVDPC 434
P Y E I CI P N + S S C C EGY G CE P
Sbjct: 321 TACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPA 380
Query: 435 ASSP---------CQN--NGTCYVDGVHFTCNCSPGFTGPTCAQLI-----------DFC 472
P C N N C V C PGF + ++ +C
Sbjct: 381 LKPPENGYFIQNTCNNHFNAACGV-------RCHPGFDLVGSSIILCLPNGLWSGSESYC 433
Query: 473 ALSPC--------AHGTCRSVGTSYK--CL--CDPGY 497
+ C H +C + YK CL CD GY
Sbjct: 434 RVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGY 470
Score = 34.3 bits (77), Expect = 0.43
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 7/112 (6%)
Query: 56 GGVCTSRPEPDPQHPAPAGEPG-YSCTCPAG--ISGANCQLVADPCASNPCHHGNCSSSS 112
GG+ + P PD H +P G C C G SG C+LV P A P +G ++
Sbjct: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCP-ALKPPENGYFIQNT 393
Query: 113 SSSSDGYLC--ICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEP 162
++ C C+ G++ L LP W+ S + +++ P ++P
Sbjct: 394 CNNHFNAACGVRCHPGFDLVGSSIIL-CLPNGLWSGSESYCRVRTCPHLRQP 444
Score = 31.2 bits (69), Expect = 3.6
Identities = 17/46 (36%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 343 VGTFCEEYDACQ-RKPCQNNASCIDANEKQDGSNFTCVCLPGYTGE 387
V C + D C C +ASC++ DGS + C C+P YTG+
Sbjct: 1739 VSPSCLDVDECAVGSDCSEHASCLNV----DGS-YICSCVPPYTGD 1779
Score = 30.8 bits (68), Expect = 4.7
Identities = 30/123 (24%), Positives = 47/123 (38%), Gaps = 33/123 (26%)
Query: 480 GTCRSVGTS---YKCLCDPGYHGLYCEEE-----------------YNECLSAPCLNAAT 519
G+C+ GT ++C+C+ GY+G + E + C+ P N +
Sbjct: 292 GSCKC-GTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS 350
Query: 520 CRDLVNGYECVCLAEYKGT-------HCELYKDPCANVSCLNGATCDSDGLNGTC--ICA 570
+ +CVC Y+ + HC K P N TC++ N C C
Sbjct: 351 PPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQN--TCNNH-FNAACGVRCH 407
Query: 571 PGF 573
PGF
Sbjct: 408 PGF 410
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 218 bits (556), Expect = 1e-56
Identities = 112/323 (34%), Positives = 149/323 (46%), Gaps = 31/323 (9%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY--DACQRKPCQNNASCIDANEKQDGSNF 376
C G C + +++C C + G CE+ C PC+N +C K+ G +
Sbjct: 550 CFNGGSCDAH--DDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC-----KEAGGEY 602
Query: 377 TCVCLPGYTGELCQ-SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
C C +TG C+ K D C PC NG TC + + C CP G+ G CE PC
Sbjct: 603 HCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCF 662
Query: 436 SSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCL--- 492
SPC N GTC F C+C G+ G C +D H T R GT +
Sbjct: 663 RSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALY 722
Query: 493 -CDPGY-------------HGLYCEE----EYNECLSAPCLNAATCRDLVNGYECVCLAE 534
CD GY HG++ E E +EC S PCL+ +C+D V GY C+C
Sbjct: 723 ACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTG 782
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGG 594
Y+G HCEL +D C C NG +C + C C GF G C+ +++ CDS+PC HGG
Sbjct: 783 YEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGG 842
Query: 595 SCLDQPNGYNCHCPHGWVGANCE 617
C Y C CP + G +CE
Sbjct: 843 RCESGGGAYLCVCPESFFGYHCE 865
Score = 210 bits (535), Expect = 3e-54
Identities = 119/361 (32%), Positives = 163/361 (45%), Gaps = 61/361 (16%)
Query: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
TC +S + EC G+C + A C C+ Y G CE + D C PC N SC
Sbjct: 345 TCETAQSPCDTKECQHGGQCQVENGSAV--CVCQAGYTGAACEMDVDDCSPDPCLNGGSC 402
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQS----KIDYCILDPCRNGATCISSLSGFTCQCPE 420
+D N+TC+C + G C++ D C+ PC NG TC+ + G+ C+CPE
Sbjct: 403 VDL-----VGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPE 457
Query: 421 GYFGSACEEKV-DPCASSPCQNNGTCYVDGVHFT-CNCSPGFTGPTCA------------ 466
G+ G C E+V D C C+N G C G + T C C GF G C
Sbjct: 458 GFMGLDCRERVPDDC---ECRNGGRCL--GANTTLCQCPLGFFGLLCEFEITAMPCNMNT 512
Query: 467 ---------------------------QLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYH 498
L C PC + G+C + SY C C G+H
Sbjct: 513 QCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFH 572
Query: 499 GLYCEE-EYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK-DPCANVSCLNGA 556
G +CE+ + C S PC N TC++ Y C C + G HCE+ K D CA+ C NG
Sbjct: 573 GKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGG 632
Query: 557 TCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
TC C C PGF+G C+I + C +PC +GG+C D+ + CHC G++G C
Sbjct: 633 TCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRC 692
Query: 617 E 617
+
Sbjct: 693 Q 693
Score = 197 bits (501), Expect = 3e-50
Identities = 108/308 (35%), Positives = 139/308 (45%), Gaps = 52/308 (16%)
Query: 356 KPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFT 415
+PC N CID + S +TC CL G+TG C ++ C PC+NG TC ++ F
Sbjct: 276 RPCLNGGKCIDDCVTGNPS-YTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFR 334
Query: 416 CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALS 475
CQCP G+ G CE PC + CQ+ G C V+ C C G+TG C +D C+
Sbjct: 335 CQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPD 394
Query: 476 PCAH-GTCRSVGTSYKCLCDPGYHGLYCE----EEYNECLSAPCLNAATCRDLVNGYECV 530
PC + G+C + +Y CLC + GL CE + CLSAPC N TC D GY C
Sbjct: 395 PCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCE 454
Query: 531 CLAEYKGTHC-ELYKDPCANVSCLNGATCDSDGLNGT-CICAPGFTGEECDIDI------ 582
C + G C E D C C NG C G N T C C GF G C+ +I
Sbjct: 455 CPEGFMGLDCRERVPDDC---ECRNGGRC--LGANTTLCQCPLGFFGLLCEFEITAMPCN 509
Query: 583 ---------------------------------NECDSNPCHHGGSCLDQPNGYNCHCPH 609
+ CDS+PC +GGSC + Y C CP
Sbjct: 510 MNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPR 569
Query: 610 GWVGANCE 617
G+ G +CE
Sbjct: 570 GFHGKHCE 577
Score = 191 bits (484), Expect = 3e-48
Identities = 103/323 (31%), Positives = 142/323 (43%), Gaps = 34/323 (10%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQNNASCIDANEKQDGSNF 376
C G C K + + C+C ++ G CE + D+C PC N +C K +
Sbjct: 589 CRNGGTC--KEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGK-----Y 641
Query: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS 436
C C PG++G C+ C PC NG TC + F C C GY G C+ +VD C
Sbjct: 642 KCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVD-CGP 700
Query: 437 SPCQNNGTCYVDGVHFTC----NCSPGFT------------------GPTCAQLIDFCAL 474
+ T +G C G++ P C + ID C
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLE-IDECRS 759
Query: 475 SPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLA 533
PC HG +C+ Y CLC GY G +CE E +EC + PC N +CR+L Y C C A
Sbjct: 760 QPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPA 819
Query: 534 EYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHG 593
+ G HCE D C + C +G C+S G C+C F G C+ + C S+PC
Sbjct: 820 GFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGR 879
Query: 594 GSCLDQPNGYNCHCPHGWVGANC 616
G CL ++C C G+ G +C
Sbjct: 880 GYCLASNGSHSCTCKVGYTGEDC 902
Score = 184 bits (468), Expect = 2e-46
Identities = 115/331 (34%), Positives = 152/331 (45%), Gaps = 37/331 (11%)
Query: 315 NDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANE-KQD 372
+D EC G+C T C C + G CE E A PC N C D +
Sbjct: 470 DDCECRNGGRCL---GANTTLCQCPLGFFGLLCEFEITAM---PCNMNTQCPDGGYCMEH 523
Query: 373 GSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEE-KV 431
G ++ CVC + S C DPC NG +C + +TC+CP G+ G CE+ +
Sbjct: 524 GGSYLCVCHTDHNAS--HSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARP 581
Query: 432 DPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCA-QLIDFCALSPCAHG-TCRSVGTSY 489
C+S PC+N GTC G + C+C FTG C D CA PC +G TC Y
Sbjct: 582 HLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKY 641
Query: 490 KCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCAN 549
KC C PG+ G +CE + C +PC+N TC D + C C A Y G C+ D C
Sbjct: 642 KCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVD-CGP 700
Query: 550 VSCLNGATCDSDGLN-----------GTCICAP---------GFTGE--ECDIDINECDS 587
+ AT +G G + AP G E +C ++I+EC S
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQC-LEIDECRS 759
Query: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
PC HGGSC D+ GY C C G+ GA+CE+
Sbjct: 760 QPCLHGGSCQDRVAGYLCLCSTGYEGAHCEL 790
Score = 179 bits (454), Expect = 8e-45
Identities = 106/326 (32%), Positives = 151/326 (46%), Gaps = 37/326 (11%)
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFT 377
+C G C ++ C C + + C PC N SC DA++ ++T
Sbjct: 513 QCPDGGYCMEHGG--SYLCVCHTDHNASHSLP-SPCDSDPCFNGGSC-DAHD----DSYT 564
Query: 378 CVCLPGYTGELCQ-SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACE-EKVDPCA 435
C C G+ G+ C+ ++ C PCRNG TC + + C CP + G CE K D CA
Sbjct: 565 CECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCA 624
Query: 436 SSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCD 494
S PC N GTC+ + C+C PGF+G C C SPC +G TC T + C C
Sbjct: 625 SGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQ 684
Query: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNG--------YEC-----------VCLAEY 535
GY G C+ E +C + AT R NG Y C + + +
Sbjct: 685 AGYMGRRCQAEV-DCGPPEEVKHATLR--FNGTRLGAVALYACDRGYSLSAPSRIRVCQP 741
Query: 536 KGTHCE----LYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCH 591
G E L D C + CL+G +C C+C+ G+ G C+++ +EC ++PC
Sbjct: 742 HGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCR 801
Query: 592 HGGSCLDQPNGYNCHCPHGWVGANCE 617
+GGSC + P Y C CP G+VG +CE
Sbjct: 802 NGGSCRNLPGAYVCRCPAGFVGVHCE 827
Score = 172 bits (436), Expect = 1e-42
Identities = 92/248 (37%), Positives = 115/248 (46%), Gaps = 20/248 (8%)
Query: 383 GYTGELCQSKIDYCILDPCRNGATCISSL----SGFTCQCPEGYFGSACEEKVDPCASSP 438
G+T +C + L PC NG CI +TC C G+ G C V+ CAS P
Sbjct: 266 GHTTSVCLA------LRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQP 319
Query: 439 CQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGY 497
CQN GTC F C C GF GPTC C C HG C+ S C+C GY
Sbjct: 320 CQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGY 379
Query: 498 HGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCEL----YKDPCANVSCL 553
G CE + ++C PCLN +C DLV Y C+C +KG CE D C + C
Sbjct: 380 TGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCH 439
Query: 554 NGATCDSDGLNGTCICAPGFTGEECDIDI-NECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
NG TC C C GF G +C + ++C+ C +GG CL N C CP G+
Sbjct: 440 NGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLGA-NTTLCQCPLGFF 495
Query: 613 GANCEIHL 620
G CE +
Sbjct: 496 GLLCEFEI 503
Score = 130 bits (328), Expect = 3e-30
Identities = 57/159 (35%), Positives = 79/159 (49%), Gaps = 6/159 (3%)
Query: 465 CAQLIDFC-ALSPCAHG-----TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAA 518
C C AL PC +G C + SY C C G+ G C + NEC S PC N
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 519 TCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
TC +N + C C A + G CE + PC C +G C + + C+C G+TG C
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAAC 384
Query: 579 DIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
++D+++C +PC +GGSC+D Y C C + G CE
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 423
Score = 128 bits (322), Expect = 2e-29
Identities = 61/160 (38%), Positives = 81/160 (50%), Gaps = 6/160 (3%)
Query: 347 CEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGAT 406
C E D C+ +PC + SC D + + C+C GY G C+ + D C PCRNG +
Sbjct: 751 CLEIDECRSQPCLHGGSCQDRV-----AGYLCLCSTGYEGAHCELERDECRAHPCRNGGS 805
Query: 407 CISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCA 466
C + + C+CP G+ G CE +VD C SSPCQ+ G C G + C C F G C
Sbjct: 806 CRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCE 865
Query: 467 QLIDFCALSPCA-HGTCRSVGTSYKCLCDPGYHGLYCEEE 505
+ D C SPC G C + S+ C C GY G C +E
Sbjct: 866 TVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKE 905
Score = 115 bits (289), Expect = 1e-25
Identities = 56/175 (32%), Positives = 80/175 (45%), Gaps = 15/175 (8%)
Query: 303 KVSTCVPGESHANDLECSGKGKCTTKPS---------EATFSCTCEEQYVGTFCE-EYDA 352
++ C P + +C +C ++P A + C C Y G CE E D
Sbjct: 735 RIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDE 794
Query: 353 CQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLS 412
C+ PC+N SC + + C C G+ G C++++D C PC++G C S
Sbjct: 795 CRAHPCRNGGSC-----RNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGG 849
Query: 413 GFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQ 467
+ C CPE +FG CE DPC SSPC G C +C C G+TG CA+
Sbjct: 850 AYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK 904
Score = 87.8 bits (216), Expect = 3e-17
Identities = 47/123 (38%), Positives = 61/123 (49%), Gaps = 7/123 (5%)
Query: 502 CEEEYNECLSA-PCLNAATC-RDLVNG---YECVCLAEYKGTHCELYKDPCANVSCLNGA 556
C + CL+ PCLN C D V G Y C CL+ + G C L + CA+ C NG
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 557 TCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGAN 615
TC + G+N C C GF G C+ + CD+ C HGG C + C C G+ GA
Sbjct: 325 TC-THGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAA 383
Query: 616 CEI 618
CE+
Sbjct: 384 CEM 386
Score = 77.0 bits (188), Expect = 6e-14
Identities = 45/158 (28%), Positives = 66/158 (41%), Gaps = 14/158 (8%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C G C P + C C +VG CE E DAC PCQ+ C + G +
Sbjct: 800 CRNGGSCRNLPG--AYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC-----ESGGGAYL 852
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437
CVC + G C++ D C PC C++S +C C GY G C +++ P +
Sbjct: 853 CVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTAL 912
Query: 438 PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALS 475
+ GV + N GP Q++D A++
Sbjct: 913 KMER---VEESGVSISWNPP---NGPAARQMLDGYAVT 944
Score = 72.8 bits (177), Expect = 1e-12
Identities = 34/86 (39%), Positives = 41/86 (47%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C A PCRNGG C + P Y C CPAG G +C+ D C S+PC HG
Sbjct: 795 CRAHPCRNGGSCRNLPG------------AYVCRCPAGFVGVHCETEVDACDSSPCQHG- 841
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S YLC+C E + G +CE
Sbjct: 842 --GRCESGGGAYLCVCPESFFGYHCE 865
Score = 69.3 bits (168), Expect = 1e-11
Identities = 32/87 (36%), Positives = 41/87 (47%), Gaps = 17/87 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-G 106
CA+QPC+NGG CT G + C CPAG G C+ PC + C H G
Sbjct: 315 CASQPCQNGGTCTH------------GINSFRCQCPAGFGGPTCETAQSPCDTKECQHGG 362
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
C + S+ +C+C GY G CE
Sbjct: 363 QCQVENGSA----VCVCQAGYTGAACE 385
Score = 65.1 bits (157), Expect = 2e-10
Identities = 31/87 (35%), Positives = 42/87 (48%), Gaps = 11/87 (12%)
Query: 49 AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNC 108
A +PC NGG C G P Y+C+C +G +G C L + CAS PC +G
Sbjct: 274 ALRPCLNGGKCID--------DCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGT 325
Query: 109 SSSSSSSSDGYLCICNEGYEGPNCEQA 135
+ +S + C C G+ GP CE A
Sbjct: 326 CTHGINS---FRCQCPAGFGGPTCETA 349
Score = 62.4 bits (150), Expect = 1e-09
Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +QPC +GG C R GY C C G GA+C+L D C ++PC +G
Sbjct: 757 CRSQPCLHGGSCQDRVA------------GYLCLCSTGYEGAHCELERDECRAHPCRNG- 803
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S + Y+C C G+ G +CE
Sbjct: 804 --GSCRNLPGAYVCRCPAGFVGVHCE 827
Score = 61.2 bits (147), Expect = 3e-09
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 15/92 (16%)
Query: 42 LSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
+ P CA+ PC NGG C G+ Y C CP G SG +C++ PC +
Sbjct: 617 IGKPDSCASGPCHNGGTCFHY----------IGK--YKCDCPPGFSGRHCEIAPSPCFRS 664
Query: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
PC +G + + C C GY G C+
Sbjct: 665 PCVNGGTCEDRDTD---FFCHCQAGYMGRRCQ 693
Score = 59.7 bits (143), Expect = 9e-09
Identities = 33/92 (35%), Positives = 43/92 (46%), Gaps = 16/92 (17%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL-VADPCASNPC 103
P C++ PCRNGG C GE Y C+CP +G +C++ D CAS PC
Sbjct: 581 PHLCSSGPCRNGGTCKEA----------GGE--YHCSCPYRFTGRHCEIGKPDSCASGPC 628
Query: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
H+G Y C C G+ G +CE A
Sbjct: 629 HNGGTCFHYIGK---YKCDCPPGFSGRHCEIA 657
Score = 59.3 bits (142), Expect = 1e-08
Identities = 34/103 (33%), Positives = 45/103 (43%), Gaps = 18/103 (17%)
Query: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP--CAS 100
S P PC + PC NGG C A + Y+C CP G G +C+ A P C+S
Sbjct: 540 SLPSPCDSDPCFNGGSC------------DAHDDSYTCECPRGFHGKHCE-KARPHLCSS 586
Query: 101 NPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
PC +G + Y C C + G +CE P A+G
Sbjct: 587 GPCRNGGTCKEAGGE---YHCSCPYRFTGRHCEIGKPDSCASG 626
Score = 56.6 bits (135), Expect = 8e-08
Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 19/94 (20%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL----VADPCASNPC 103
C+ PC NGG C Y+C C G C+ V D C S PC
Sbjct: 391 CSPDPCLNGGSCVDLVG------------NYTCLCAEPFKGLRCETGDHPVPDACLSAPC 438
Query: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
H+G + + GY+C C EG+ G +C + +P
Sbjct: 439 HNGG---TCVDADQGYVCECPEGFMGLDCRERVP 469
Score = 53.1 bits (126), Expect = 9e-07
Identities = 41/138 (29%), Positives = 49/138 (35%), Gaps = 53/138 (38%)
Query: 44 APGPCAAQPCRNGGVCTSR------------------------PEPDPQHPAP------- 72
AP PC PC NGG C R P + +H
Sbjct: 657 APSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRL 716
Query: 73 ------AGEPGYSCTCPAGISGANCQ-----------LVADPCASNPCHHGNCSSSSSSS 115
A + GYS + P+ I CQ L D C S PC HG S
Sbjct: 717 GAVALYACDRGYSLSAPSRIRV--CQPHGVWSEPPQCLEIDECRSQPCLHG---GSCQDR 771
Query: 116 SDGYLCICNEGYEGPNCE 133
GYLC+C+ GYEG +CE
Sbjct: 772 VAGYLCLCSTGYEGAHCE 789
Score = 50.4 bits (119), Expect = 6e-06
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 20/97 (20%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC-QLVADPCASNPC 103
P C + PC NGG C + GY C CP G G +C + V D C
Sbjct: 430 PDACLSAPCHNGGTCVD------------ADQGYVCECPEGFMGLDCRERVPDDCECR-- 475
Query: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
+ G C ++++ LC C G+ G CE + ++P
Sbjct: 476 NGGRCLGANTT-----LCQCPLGFFGLLCEFEITAMP 507
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 11/94 (11%)
Query: 50 AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCS 109
A PC C PD + G Y C C + ++ + PC S+PC +G
Sbjct: 505 AMPCNMNTQC-----PDGGYCMEHGG-SYLCVCHTDHNASHS--LPSPCDSDPCFNGG-- 554
Query: 110 SSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
S + D Y C C G+ G +CE+A P L ++G
Sbjct: 555 -SCDAHDDSYTCECPRGFHGKHCEKARPHLCSSG 587
Score = 42.4 bits (98), Expect = 0.002
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 434 CASSPCQNNGTCYVDGVHFTCNCSPGFTGPTC 465
C+ +PCQN GTC +C+C PGF G C
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 16/60 (26%)
Query: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL----VADPC 98
+ PG C+ PC+NGG C G +SC C G G C+L V+ PC
Sbjct: 1306 NVPGNCSENPCQNGGTCV------------PGADAHSCDCGPGFKGRRCELACIKVSRPC 1353
Score = 40.8 bits (94), Expect = 0.005
Identities = 13/34 (38%), Positives = 21/34 (61%)
Query: 585 CDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
C NPC +GG+C+ + ++C C G+ G CE+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 38.5 bits (88), Expect = 0.023
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACE 428
C +PC+NG TC+ +C C G+ G CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 35.8 bits (81), Expect = 0.15
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC 590
C+ C NG TC +C C PGF G C++ + S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 34.7 bits (78), Expect = 0.33
Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 472 CALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYE-C 529
C+ +PC +G TC ++ C C PG+ G CE + +S PC + +E
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPCTRLFSETKAFPVWEGG 1369
Query: 530 VCLAEYKGTHCELYKDPCANVSC 552
VC YK + +++D C SC
Sbjct: 1370 VCHHVYKRVY-RVHQDICFKESC 1391
Score = 32.7 bits (73), Expect = 1.2
Identities = 13/38 (34%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 98 CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
C+ NPC +G + +D + C C G++G CE A
Sbjct: 1311 CSENPCQNGG---TCVPGADAHSCDCGPGFKGRRCELA 1345
Score = 32.7 bits (73), Expect = 1.2
Identities = 12/38 (31%), Positives = 18/38 (47%), Gaps = 5/38 (13%)
Query: 353 CQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQ 390
C PCQN +C+ + +C C PG+ G C+
Sbjct: 1311 CSENPCQNGGTCVPGADAH-----SCDCGPGFKGRRCE 1343
Score = 30.8 bits (68), Expect = 4.7
Identities = 14/45 (31%), Positives = 18/45 (40%), Gaps = 12/45 (26%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC 91
PC + PC G C A +SCTC G +G +C
Sbjct: 870 PCFSSPCGGRGYCL------------ASNGSHSCTCKVGYTGEDC 902
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 184 bits (467), Expect = 3e-46
Identities = 93/242 (38%), Positives = 112/242 (46%), Gaps = 18/242 (7%)
Query: 351 DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISS 410
D C PCQN +C + C C GY G C+ +D C PC NG TC +
Sbjct: 927 DLCLSSPCQNQGTC----HNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Query: 411 L---SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCA 466
+ FTC CP G+ G C D C C N G C VDGV ++TC C + G C
Sbjct: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC-VDGVGNYTCQCPLQYEGKACE 1041
Query: 467 QLIDFCA--LSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDL 523
QL+D C+ L+PC H C +C C PGY G C E ++C C N A C D
Sbjct: 1042 QLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDE 1101
Query: 524 VNGYECVCLAEYKGTHCEL------YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEE 577
VN Y C+C Y G CE+ K PC C NGA C G C C PGF G E
Sbjct: 1102 VNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPE 1161
Query: 578 CD 579
C+
Sbjct: 1162 CE 1163
Score = 176 bits (447), Expect = 5e-44
Identities = 88/241 (36%), Positives = 123/241 (51%), Gaps = 13/241 (5%)
Query: 390 QSKIDYCILDPCRNGATCISS-LSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV- 447
Q+K D C+ PC+N TC + L + C CP GY G CE +D C+S PC+N GTC+
Sbjct: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Query: 448 --DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEE 504
+ FTC+C GF GPTC D C CA+G C +Y C C Y G CE+
Sbjct: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
Query: 505 EYNECLSA--PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDG 562
+ C PC + A C +G C C+ Y G +C +D C + C NGA C +
Sbjct: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
Query: 563 LNGTCICAPGFTGEECDIDIN------ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
+ +C+CA G++G+ C+I + C+ C +G +C+DQ N C C G+ G C
Sbjct: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Query: 617 E 617
E
Sbjct: 1163 E 1163
Score = 157 bits (396), Expect = 4e-38
Identities = 84/233 (36%), Positives = 105/233 (45%), Gaps = 13/233 (5%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFT 377
C +G C P E + C C Y G CE D+C PC+N +C A E +D FT
Sbjct: 934 CQNQGTCHNDPLEV-YRCACPSGYKGRDCEVSLDSCSSGPCENGGTC-HAQEGEDAP-FT 990
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS- 436
C C G+ G C D C+ C NG C+ + +TCQCP Y G ACE+ VD C+
Sbjct: 991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPD 1050
Query: 437 -SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT-CRSVGTSYKCLCD 494
+PCQ+ C C C PG+ G C++ D C C +G C SY CLC
Sbjct: 1051 LNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCA 1110
Query: 495 PGYHGLYCE------EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
GY G CE + C C N A C D N C CL + G CE
Sbjct: 1111 EGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 145 bits (365), Expect = 2e-34
Identities = 73/212 (34%), Positives = 102/212 (48%), Gaps = 10/212 (4%)
Query: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFC 472
F CQ P A + K D C SSPCQN GTC+ D + + C C G+ G C +D C
Sbjct: 912 FECQGPPTL---AVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
Query: 473 ALSPCAHG-TCRSV---GTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYE 528
+ PC +G TC + + C C G+ G C ++C+ C N C D V Y
Sbjct: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYT 1028
Query: 529 CVCLAEYKGTHCELYKDPCANV--SCLNGATCDSDGLNGTCICAPGFTGEECDIDINECD 586
C C +Y+G CE D C+ C + A C C C PG+ G+ C + ++C
Sbjct: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR 1088
Query: 587 SNPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
+ C +G C+D+ N Y+C C G+ G CEI
Sbjct: 1089 DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
Score = 113 bits (283), Expect = 6e-25
Identities = 60/173 (34%), Positives = 77/173 (44%), Gaps = 16/173 (9%)
Query: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DACQR--KPCQNNA 362
TC D C+ G C ++C C QY G CE+ D C PCQ+ A
Sbjct: 1001 TCGVNTDDCVDHACANGGVCVD--GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEA 1058
Query: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY 422
C+ DG C C+PGY G+ C D C C+NGA C+ ++ ++C C EGY
Sbjct: 1059 QCVGT---PDGPR--CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGY 1113
Query: 423 FGSACE------EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
G CE PC + CQN C G C C PGF GP C +L+
Sbjct: 1114 SGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
Score = 78.6 bits (192), Expect = 2e-14
Identities = 42/124 (33%), Positives = 61/124 (49%), Gaps = 11/124 (8%)
Query: 395 YCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD-PCASSPCQNNGTCYVDGVHFT 453
YC+ C+ AT G C C G+ G C++ D PC C + +D + ++
Sbjct: 1346 YCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400
Query: 454 CNCSPGFTGPTCAQ---LIDFCALSPCAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYNEC 509
C C G++G C Q L + C C HG C++ GT C+CDPG+ G CE+E +EC
Sbjct: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
Query: 510 LSAP 513
P
Sbjct: 1460 RGDP 1463
Score = 67.8 bits (164), Expect = 3e-11
Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 8/124 (6%)
Query: 472 CALSPCAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYN-ECLSAPCLNAATCRDLVNGYEC 529
C C HG C+ T C C+ G+ GL+C++ + C C++ Y C
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
Query: 530 VCLAEYKGTHCE---LYKDPCANVSCLNGATCDSDGLNGT-CICAPGFTGEECDIDINEC 585
C Y G C +PC + CL+G C + G G C+C PGF+GE C+ + +EC
Sbjct: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
Query: 586 DSNP 589
+P
Sbjct: 1460 RGDP 1463
Score = 66.6 bits (161), Expect = 8e-11
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 24/120 (20%)
Query: 26 AGPRG--SSLANPVPAAPLSAPGP-----------CAAQPCRNGGVCTSRPEPDPQHPAP 72
AGP+ L PA GP C + PC+N G C + P
Sbjct: 894 AGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEV------ 947
Query: 73 AGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNC 132
Y C CP+G G +C++ D C+S PC +G + + C C G+EGP C
Sbjct: 948 -----YRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
Score = 64.3 bits (155), Expect = 4e-10
Identities = 27/79 (34%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 545 DPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG- 602
D C + C N TC +D L C C G+ G +C++ ++ C S PC +GG+C Q
Sbjct: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
Query: 603 --YNCHCPHGWVGANCEIH 619
+ C CP G+ G C ++
Sbjct: 987 APFTCSCPTGFEGPTCGVN 1005
Score = 57.4 bits (137), Expect = 5e-08
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C++ PC NGG C ++ D AP ++C+CP G G C + D C + C +G
Sbjct: 968 CSSGPCENGGTCHAQEGED----AP-----FTCSCPTGFEGPTCGVNTDDCVDHACANGG 1018
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ Y C C YEG CEQ
Sbjct: 1019 VCVDGVGN---YTCQCPLQYEGKACEQ 1042
Score = 57.4 bits (137), Expect = 5e-08
Identities = 32/94 (34%), Positives = 41/94 (43%), Gaps = 18/94 (19%)
Query: 44 APGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQ---LVADPCAS 100
A GPC C +G P YSC C G SGA C +A+PC
Sbjct: 1377 ADGPCHGHKCVHGQC------------VPLDALSYSCQCQDGYSGALCNQAGALAEPCRG 1424
Query: 101 NPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C HG+C +S + G C+C+ G+ G CEQ
Sbjct: 1425 LQCLHGHCQASGTK---GAHCVCDPGFSGELCEQ 1455
Score = 55.1 bits (131), Expect = 2e-07
Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKD-PCANVSCLNGATCDSDGLNGTC 567
C CL+ + G C C A + G HC+ D PC C++G D L+ +C
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
Query: 568 ICAPGFTGEECDID---INECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
C G++G C+ C C HG G +C C G+ G CE
Sbjct: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Score = 53.9 bits (128), Expect = 5e-07
Identities = 28/100 (28%), Positives = 42/100 (42%), Gaps = 14/100 (14%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-------EYDACQRKPCQ 359
C + D C +C + + ++SC C E Y G CE C+ CQ
Sbjct: 1080 CSENQDDCRDHRCQNGAQCMDEVN--SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQ 1137
Query: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD 399
N A+C+D G+ C CLPG+ G C+ + +D
Sbjct: 1138 NGANCVD-----QGNRPVCQCLPGFGGPECEKLLSVNFVD 1172
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/90 (35%), Positives = 38/90 (42%), Gaps = 19/90 (21%)
Query: 51 QPCRN----GGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHH 105
+PCR G+C P PG C C AG G +C AD PC + C H
Sbjct: 1340 EPCRKLYCLHGICQ-----------PNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH 1388
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
G C + S Y C C +GY G C QA
Sbjct: 1389 GQCVPLDALS---YSCQCQDGYSGALCNQA 1415
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 15/140 (10%)
Query: 308 VPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA 367
VPG L C G C + C CE +VG C D PC +
Sbjct: 1336 VPGCEPCRKLYCL-HGICQPNATPGPM-CHCEAGWVGLHC---DQPADGPCHGHKCVHGQ 1390
Query: 368 NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCI------SSLSGFTCQCPEG 421
D +++C C GY+G LC + +PCR G C+ S G C C G
Sbjct: 1391 CVPLDALSYSCQCQDGYSGALCNQA--GALAEPCR-GLQCLHGHCQASGTKGAHCVCDPG 1447
Query: 422 YFGSACEEKVDPCASSPCQN 441
+ G CE++ + C P ++
Sbjct: 1448 FSGELCEQESE-CRGDPVRD 1466
Score = 51.2 bits (121), Expect = 3e-06
Identities = 38/122 (31%), Positives = 46/122 (37%), Gaps = 32/122 (26%)
Query: 48 CAAQPCRNGGVCTS-------------------------RPEPDP-QHPAPA-GEP-GYS 79
C C NGGVC P+ +P QH A G P G
Sbjct: 1009 CVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPR 1068
Query: 80 CTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSL 139
C C G +G NC D C + C +G + + Y C+C EGY G CE P L
Sbjct: 1069 CECMPGYAGDNCSENQDDCRDHRCQNG---AQCMDEVNSYSCLCAEGYSGQLCE-IPPHL 1124
Query: 140 PA 141
PA
Sbjct: 1125 PA 1126
Score = 47.0 bits (110), Expect = 6e-05
Identities = 26/92 (28%), Positives = 36/92 (39%), Gaps = 15/92 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
C C+NG C YSC C G SG C++ P +PC
Sbjct: 1087 CRDHRCQNGAQCMDEVN------------SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
Query: 107 NCSSSSSSSSDGY--LCICNEGYEGPNCEQAL 136
C + ++ G +C C G+ GP CE+ L
Sbjct: 1135 ECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 545 DPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDIN-ECDSNPCHHGGSCLDQPNG 602
+PC + CL+G C + G C C G+ G CD + C + C HG
Sbjct: 1340 EPCRKLYCLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS 1398
Query: 603 YNCHCPHGWVGANCEIHLQWKSGHMAE 629
Y+C C G+ GA C ++G +AE
Sbjct: 1399 YSCQCQDGYSGALCN-----QAGALAE 1420
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Query: 577 ECDIDINECDSNPCHHGGSCLDQP-NGYNCHCPHGWVGANCEIHL 620
+CD+ C S+PC + G+C + P Y C CP G+ G +CE+ L
Sbjct: 925 KCDL----CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
Score = 35.0 bits (79), Expect = 0.25
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 4/48 (8%)
Query: 92 QLVADPCASNPCHH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138
Q D C S+PC + G C + + Y C C GY+G +CE +L S
Sbjct: 923 QAKCDLCLSSPCQNQGTCHNDPL---EVYRCACPSGYKGRDCEVSLDS 967
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 181 bits (460), Expect = 2e-45
Identities = 93/244 (38%), Positives = 124/244 (50%), Gaps = 21/244 (8%)
Query: 351 DACQRKPCQNNASCIDANEKQDGSN-FTCVCLPGYTGELCQSKIDYCILDPCRNGATCIS 409
+AC PC+NN +C QD + C C Y G+ C I+ CI +PC++G TC
Sbjct: 918 NACLSSPCKNNGTCT-----QDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHL 972
Query: 410 SLS---GFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTC 465
S S GF+C CP G+ G CE D C + C+NN TC VDG+ ++ C C P +TG C
Sbjct: 973 SDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATC-VDGINNYVCICPPNYTGELC 1031
Query: 466 AQLIDFCA--LSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRD 522
++ID C L+ C H C + + C C PGY G CE + ++C++ C + A C D
Sbjct: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
Query: 523 LVNGYECVCLAEYKGTHCE-------LYKDPCANVSCLNGATCDSDGLNGTCICAPGFTG 575
+NGY C C + G CE L PC C NGA C TC C PGF G
Sbjct: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
Query: 576 EECD 579
C+
Sbjct: 1152 PRCE 1155
Score = 158 bits (400), Expect = 1e-38
Identities = 81/242 (33%), Positives = 114/242 (47%), Gaps = 16/242 (6%)
Query: 391 SKIDYCILDPCRNGATCISS-LSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDG 449
+K + C+ PC+N TC + + C CP Y G C ++ C +PCQ+ GTC++
Sbjct: 915 AKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD 974
Query: 450 VH---FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEE 505
H F+C+C GF G C D C + C + TC +Y C+C P Y G C+E
Sbjct: 975 SHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEV 1034
Query: 506 YNECLSAP--CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGL 563
+ C+ C + A C L G+ C C+ Y G CE D C C +GA C D +
Sbjct: 1035 IDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQC-VDTI 1093
Query: 564 NG-TCICAPGFTGEECD-------IDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGAN 615
NG TC C GF+G C+ + + CD C +G C+ C CP G+ G
Sbjct: 1094 NGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Query: 616 CE 617
CE
Sbjct: 1154 CE 1155
Score = 134 bits (336), Expect = 4e-31
Identities = 76/216 (35%), Positives = 106/216 (49%), Gaps = 26/216 (12%)
Query: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEAT-FSCTCEEQYVGTFCE-EYDACQRKPCQ 359
V ++TC+ C G C S FSC+C + G CE D C+ C+
Sbjct: 954 VPINTCIQNP-------CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCE 1006
Query: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCI--LDPCRNGATCISSLSGFTCQ 417
NNA+C+D +N+ C+C P YTGELC ID+C+ L+ C++ A CI GF+C+
Sbjct: 1007 NNATCVDGI-----NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCE 1061
Query: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCAL-- 474
C GY G CE D C + C++ C VD ++ +TC C GF+GP C L
Sbjct: 1062 CVPGYSGKLCETDNDDCVAHKCRHGAQC-VDTINGYTCTCPQGFSGPFCEHPPPMVLLQT 1120
Query: 475 SPCAHGTCRS------VGTSYKCLCDPGYHGLYCEE 504
SPC C++ V C C PG+ G CE+
Sbjct: 1121 SPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
Score = 125 bits (314), Expect = 1e-28
Identities = 60/173 (34%), Positives = 85/173 (49%), Gaps = 17/173 (9%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DAC--QRKPCQNNAS 363
C D +C C + + C C Y G C+E D C + CQ+ A
Sbjct: 993 CEINPDDCEDNDCENNATCVDGINN--YVCICPPNYTGELCDEVIDHCVPELNLCQHEAK 1050
Query: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
CI ++ F+C C+PGY+G+LC++ D C+ CR+GA C+ +++G+TC CP+G+
Sbjct: 1051 CIPLDK-----GFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFS 1105
Query: 424 GSACEE-------KVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
G CE + PC CQN C V TC C PGF GP C +LI
Sbjct: 1106 GPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
Score = 78.6 bits (192), Expect = 2e-14
Identities = 89/417 (21%), Positives = 144/417 (34%), Gaps = 79/417 (18%)
Query: 75 EPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ G+SC C G SG C+ D C ++ C HG + + +GY C C +G+ GP CE
Sbjct: 1055 DKGFSCECVPGYSGKLCETDNDDCVAHKCRHG---AQCVDTINGYTCTCPQGFSGPFCEH 1111
Query: 135 ALPS--LPATGWTESMAPRQLQPVPATQEPDKILP------------------------- 167
P L + + Q + QEP P
Sbjct: 1112 PPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVEL 1171
Query: 168 -----RSQATVTLPTWQPKTG-----------------QKVVEMKWDQVEVIPDIACGNA 205
R QA ++L K Q V + +D + P
Sbjct: 1172 ASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVE 1231
Query: 206 SSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASG 265
+ N + + Q ++ + + SL L K A G + G + S
Sbjct: 1232 TVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGG-----IPTST 1286
Query: 266 GLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSG---- 321
GL L + F G +++ +R+ ++ +P +S C
Sbjct: 1287 GLSALRQGTDRPLGGFHGCIHE--------VRINNELQDFKALPPQSLGVSPGCKSCTVC 1338
Query: 322 -KGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVC 380
G C + ++ C C + G C++ R PC + C G+++ C C
Sbjct: 1339 KHGLCRSVEKDSVV-CECRPGWTGPLCDQE---ARDPCLGH-RCHHGKCVATGTSYMCKC 1393
Query: 381 LPGYTGELCQSKID---YCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
GY G+LC +K D C C +G IS C C G+ G C+++ +PC
Sbjct: 1394 AEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
Score = 72.8 bits (177), Expect = 1e-12
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 401 CRNGATCISSLSGFTCQCPEGYFGSACEEKV-DPCASSPCQNNGTCYVDGVHFTCNCSPG 459
C++G C+C G+ G C+++ DPC C ++G C G + C C+ G
Sbjct: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEG 1396
Query: 460 FTGPTCAQLID---FCALSPCAHGTCR--SVGTSYKCLCDPGYHGLYCEEEYNECL 510
+ G C D C+ C HG C G Y CLC PG+ G +C++E N CL
Sbjct: 1397 YGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQE-NPCL 1450
Score = 71.6 bits (174), Expect = 2e-12
Identities = 36/112 (32%), Positives = 45/112 (40%), Gaps = 11/112 (9%)
Query: 22 LLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT 81
LLL PV ++ C + PC+N G CT P Y C
Sbjct: 894 LLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDP-----------VELYRCA 942
Query: 82 CPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
CP G +C + + C NPC HG S S DG+ C C G+EG CE
Sbjct: 943 CPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCE 994
Score = 68.6 bits (166), Expect = 2e-11
Identities = 42/120 (35%), Positives = 55/120 (45%), Gaps = 8/120 (6%)
Query: 434 CASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQLI-DFCALSPCAHGTCRSVGTSYKC 491
C S +G C V+ C C PG+TGP C Q D C C HG C + GTSY C
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
Query: 492 LCDPGYHGLYCE---EEYNECLSAPCLNAATCRDLVNGYE-CVCLAEYKGTHCELYKDPC 547
C GY G C+ + N C + C + C G C+C + G HC+ ++PC
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPC 1449
Score = 68.6 bits (166), Expect = 2e-11
Identities = 36/95 (37%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 378 CVCLPGYTGELC-QSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD---P 433
C C PG+TG LC Q D C+ C +G C+++ + + C+C EGY G C+ K D
Sbjct: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
Query: 434 CASSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQ 467
C++ C ++G C++ D C C PGF+G C Q
Sbjct: 1412 CSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Score = 68.2 bits (165), Expect = 3e-11
Identities = 29/77 (37%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 547 CANVSCLNGATCDSDGLN-GTCICAPGFTGEECDIDINECDSNPCHHGGSCL---DQPNG 602
C + C N TC D + C C + G++C + IN C NPC HGG+C +G
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
Query: 603 YNCHCPHGWVGANCEIH 619
++C CP G+ G CEI+
Sbjct: 980 FSCSCPLGFEGQRCEIN 996
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/143 (33%), Positives = 59/143 (41%), Gaps = 26/143 (18%)
Query: 467 QLIDFCALSP--------------CAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYNE-CL 510
+L DF AL P C HG CRSV S C C PG+ G C++E + CL
Sbjct: 1314 ELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL 1373
Query: 511 SAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDP---CANVSCLNGATCDSDGLNGTC 567
C + C Y C C Y G C+ D C+ C +G SD C
Sbjct: 1374 GHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYC 1432
Query: 568 ICAPGFTGEECDIDINECDSNPC 590
+C PGF+GE C NPC
Sbjct: 1433 LCQPGFSGEHCQ------QENPC 1449
Score = 62.8 bits (151), Expect = 1e-09
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 12/89 (13%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC++GG C H + + + G+SC+CP G G C++ D C N C +
Sbjct: 959 CIQNPCQHGGTC---------HLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCEN-- 1007
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+++ + Y+CIC Y G C++ +
Sbjct: 1008 -NATCVDGINNYVCICPPNYTGELCDEVI 1035
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/105 (27%), Positives = 37/105 (35%), Gaps = 19/105 (18%)
Query: 38 PAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLV--- 94
P A PC C +G A Y C C G G C
Sbjct: 1362 PLCDQEARDPCLGHRCHHG-------------KCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
Query: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSL 139
A+ C++ CHHG C S C+C G+ G +C+Q P L
Sbjct: 1409 ANACSAFKCHHGQCHISDQGEP---YCLCQPGFSGEHCQQENPCL 1450
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/91 (28%), Positives = 29/91 (31%), Gaps = 17/91 (18%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS--NP 102
P C C N C G Y C CP +G C V D C N
Sbjct: 997 PDDCEDNDCENNATCVD------------GINNYVCICPPNYTGELCDEVIDHCVPELNL 1044
Query: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
C H + G+ C C GY G CE
Sbjct: 1045 CQH---EAKCIPLDKGFSCECVPGYSGKLCE 1072
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 32/153 (20%)
Query: 323 GKCTTKPSEATFSCTCEEQYVGTFC----EEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
GKC + ++ C C E Y G C + +AC C + I D C
Sbjct: 1380 GKCVA--TGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHI-----SDQGEPYC 1432
Query: 379 VCLPGYTGELCQSKIDYCILDPC------------RNGATCISSLSGFTCQCPEGYFGSA 426
+C PG++GE CQ + +PC + A+C ++ +C G
Sbjct: 1433 LCQPGFSGEHCQQE------NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQC 1486
Query: 427 CEEKVDPCASSPCQ-NNGTCYVDGV--HFTCNC 456
C+ Q +G+ +V+ V H C C
Sbjct: 1487 CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
Score = 30.0 bits (66), Expect = 8.0
Identities = 22/84 (26%), Positives = 30/84 (35%), Gaps = 15/84 (17%)
Query: 10 GAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVC-TSRPEPDPQ 68
GAQ + + G G +P P L PC C+NG C + EP
Sbjct: 1086 GAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQT-SPCDQYECQNGAQCIVVQQEP--- 1141
Query: 69 HPAPAGEPGYSCTCPAGISGANCQ 92
+C CP G +G C+
Sbjct: 1142 ----------TCRCPPGFAGPRCE 1155
>gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]
Length = 619
Score = 181 bits (460), Expect = 2e-45
Identities = 105/348 (30%), Positives = 160/348 (45%), Gaps = 9/348 (2%)
Query: 237 ILLWKVTATGFQQC---SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSI 293
I L V+ T F C + + + + + G + + L++G ++FI + +
Sbjct: 101 INLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP 160
Query: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC 353
+ LRL + VK C ES +++ CSG GKC ++ T+SC C+ + G +C+E DAC
Sbjct: 161 LGLRLNVTVKQQFCQ--ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
Query: 354 QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG 413
KPC+NN SCI+ E D + CVC P +TG+ C I C C +G + +
Sbjct: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
Query: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
F C+C E + G CE PC S G C +T C G + + +
Sbjct: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
Query: 474 LSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532
L PC +GT C + C+C P + L C+ C S P N ATC+ Y C C+
Sbjct: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
Query: 533 AEYKGTHCELYKDPC--ANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
+ + +CE D C +++CLN C + +C PG T C
Sbjct: 398 SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
Score = 119 bits (297), Expect = 1e-26
Identities = 66/225 (29%), Positives = 95/225 (42%), Gaps = 9/225 (4%)
Query: 401 CRNGATCISSL--SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV-----DGVHFT 453
C C+S ++C C + G C+E +D C+ PC+NNG+C D +
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
Query: 454 CNCSPGFTGPTCAQLIDFCALSPCAHGTCRSV-GTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C P FTG C+++I C C HG C ++ S+ C CD + G +CE C+S
Sbjct: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
C + + Y C + E + V C NG C + CIC+P
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
FT C C+S P + +C Y C C G+ NCE
Sbjct: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
Score = 70.5 bits (171), Expect = 5e-12
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ +PC+N G C ++ E E Y C C +G NC + C + C HGN
Sbjct: 217 CSFKPCKNNGSCINKREN-------WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE-QALPSLPATGWTESMAP 150
CS+ +S+S ++C C+E + GP CE A P + W + P
Sbjct: 270 CSNITSNS---FICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/163 (26%), Positives = 62/163 (38%), Gaps = 24/163 (14%)
Query: 475 SPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAE 534
SPC G +V T + C +C CL+ A + Y C C
Sbjct: 157 SPCPLGLRLNV-TVKQQFCQESLSSEFCSGH------GKCLSEAWSKT----YSCHCQPP 205
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGT-----CICAPGFTGEECDIDINECDSNP 589
+ G +C+ D C+ C N +C + N C+C P FTG+ C I +C +
Sbjct: 206 FSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV 264
Query: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCEIH-------LQWKSG 625
C HG N + C C + G CE+ L WK G
Sbjct: 265 CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSS-SSDGYLCICNEGYEGPNCEQA 135
YSC C SG CQ + D C+ PC ++G+C + + Y C+C+ + G NC +
Sbjct: 198 YSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Query: 136 L 136
+
Sbjct: 257 I 257
Score = 30.8 bits (68), Expect = 4.7
Identities = 29/128 (22%), Positives = 42/128 (32%), Gaps = 21/128 (16%)
Query: 15 PALALLLLLLGAGPRGSSLAN-PVPAAPLSAPGPCAAQ-----PCRNGGVCTSRPEPDPQ 68
P ++LL G P SS P S G PC+NG C
Sbjct: 297 PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--- 353
Query: 69 HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYE 128
C C + C+ + C S P + +++ Y C C G+
Sbjct: 354 ---------VMCICSPIFTDLLCKSIQTSCESFPLRN---NATCKKCEKDYPCSCISGFT 401
Query: 129 GPNCEQAL 136
NCE+A+
Sbjct: 402 EKNCEKAI 409
>gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]
Length = 594
Score = 181 bits (460), Expect = 2e-45
Identities = 105/348 (30%), Positives = 160/348 (45%), Gaps = 9/348 (2%)
Query: 237 ILLWKVTATGFQQC---SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSI 293
I L V+ T F C + + + + + G + + L++G ++FI + +
Sbjct: 101 INLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP 160
Query: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC 353
+ LRL + VK C ES +++ CSG GKC ++ T+SC C+ + G +C+E DAC
Sbjct: 161 LGLRLNVTVKQQFCQ--ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
Query: 354 QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG 413
KPC+NN SCI+ E D + CVC P +TG+ C I C C +G + +
Sbjct: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
Query: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
F C+C E + G CE PC S G C +T C G + + +
Sbjct: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
Query: 474 LSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532
L PC +GT C + C+C P + L C+ C S P N ATC+ Y C C+
Sbjct: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
Query: 533 AEYKGTHCELYKDPC--ANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
+ + +CE D C +++CLN C + +C PG T C
Sbjct: 398 SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
Score = 119 bits (297), Expect = 1e-26
Identities = 66/225 (29%), Positives = 95/225 (42%), Gaps = 9/225 (4%)
Query: 401 CRNGATCISSL--SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV-----DGVHFT 453
C C+S ++C C + G C+E +D C+ PC+NNG+C D +
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
Query: 454 CNCSPGFTGPTCAQLIDFCALSPCAHGTCRSV-GTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C P FTG C+++I C C HG C ++ S+ C CD + G +CE C+S
Sbjct: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
C + + Y C + E + V C NG C + CIC+P
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
Query: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
FT C C+S P + +C Y C C G+ NCE
Sbjct: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
Score = 70.5 bits (171), Expect = 5e-12
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ +PC+N G C ++ E E Y C C +G NC + C + C HGN
Sbjct: 217 CSFKPCKNNGSCINKREN-------WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE-QALPSLPATGWTESMAP 150
CS+ +S+S ++C C+E + GP CE A P + W + P
Sbjct: 270 CSNITSNS---FICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/163 (26%), Positives = 62/163 (38%), Gaps = 24/163 (14%)
Query: 475 SPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAE 534
SPC G +V T + C +C CL+ A + Y C C
Sbjct: 157 SPCPLGLRLNV-TVKQQFCQESLSSEFCSGH------GKCLSEAWSKT----YSCHCQPP 205
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGT-----CICAPGFTGEECDIDINECDSNP 589
+ G +C+ D C+ C N +C + N C+C P FTG+ C I +C +
Sbjct: 206 FSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV 264
Query: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCEIH-------LQWKSG 625
C HG N + C C + G CE+ L WK G
Sbjct: 265 CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 78 YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSS-SSDGYLCICNEGYEGPNCEQA 135
YSC C SG CQ + D C+ PC ++G+C + + Y C+C+ + G NC +
Sbjct: 198 YSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Query: 136 L 136
+
Sbjct: 257 I 257
Score = 30.8 bits (68), Expect = 4.7
Identities = 29/128 (22%), Positives = 42/128 (32%), Gaps = 21/128 (16%)
Query: 15 PALALLLLLLGAGPRGSSLAN-PVPAAPLSAPGPCAAQ-----PCRNGGVCTSRPEPDPQ 68
P ++LL G P SS P S G PC+NG C
Sbjct: 297 PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--- 353
Query: 69 HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYE 128
C C + C+ + C S P + +++ Y C C G+
Sbjct: 354 ---------VMCICSPIFTDLLCKSIQTSCESFPLRN---NATCKKCEKDYPCSCISGFT 401
Query: 129 GPNCEQAL 136
NCE+A+
Sbjct: 402 EKNCEKAI 409
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 166 bits (419), Expect = 9e-41
Identities = 113/389 (29%), Positives = 169/389 (43%), Gaps = 56/389 (14%)
Query: 273 MLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGES------------HANDLECS 320
++ L NN N S + L L L C+P + H ND+
Sbjct: 781 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 840
Query: 321 GKGKCTTKPSEATFS-------CTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQD 372
+G + + + C C Q++ + + EY ++P A C E D
Sbjct: 841 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEY----KEP--GIARCAGPGEMAD 894
Query: 373 -------GSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISS-LSGFTCQCPEGYFG 424
FTC G +K + C+ +PC+N TC S + + C CP G+ G
Sbjct: 895 KLLLTTPSKKFTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKG 951
Query: 425 SACEEKVDPCASSPCQNNGTCYV-----DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH 479
C+ + C S+PC++ GTC++ DG F C C+ GF G C +D C + C +
Sbjct: 952 QDCDVPIHACISNPCKHGGTCHLKEGEEDG--FWCICADGFEGENCEVNVDDCEDNDCEN 1009
Query: 480 G-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA--PCLNAATCRDLVNGYECVCLAEYK 536
TC +Y CLC P Y G CEE+ + C PC + + C G++C C Y
Sbjct: 1010 NSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYV 1069
Query: 537 GTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDID-------INECDSN 588
G HC++ D C + C NGA C +D +NG TCIC G++G C+ + CD+
Sbjct: 1070 GEHCDIDFDDCQDNKCKNGAHC-TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNF 1128
Query: 589 PCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
C +G C+ + N C C G+ G CE
Sbjct: 1129 DCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
Score = 129 bits (325), Expect = 7e-30
Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 19/199 (9%)
Query: 319 CSGKGKCTTKPSEAT-FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNF 376
C G C K E F C C + + G CE D C+ C+NN++C+D +N+
Sbjct: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGI-----NNY 1020
Query: 377 TCVCLPGYTGELCQSKIDYCI--LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
TC+C P YTGELC+ K+D+C L+PC++ + CI + GF C C GY G C+ D C
Sbjct: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
Query: 435 ASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTC--AQLIDFCALSPCAHGTCRSVGTSYK- 490
+ C+N C D V+ +TC C G++G C + + SPC + C++
Sbjct: 1081 QDNKCKNGAHC-TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
Query: 491 -----CLCDPGYHGLYCEE 504
C C PGY G CE+
Sbjct: 1140 INEPICQCLPGYQGEKCEK 1158
Score = 127 bits (319), Expect = 4e-29
Identities = 71/211 (33%), Positives = 102/211 (48%), Gaps = 46/211 (21%)
Query: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
FTCQ P A K +PC S+PC+N+GT CN P +DF
Sbjct: 905 FTCQGPVDVNILA---KCNPCLSNPCKNDGT---------CNSDP----------VDF-- 940
Query: 474 LSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCR---DLVNGYECV 530
Y+C C G+ G C+ + C+S PC + TC +G+ C+
Sbjct: 941 ---------------YRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCI 985
Query: 531 CLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINEC--DS 587
C ++G +CE+ D C + C N +TC DG+N TC+C P +TGE C+ ++ C D
Sbjct: 986 CADGFEGENCEVNVDDCEDNDCENNSTC-VDGINNYTCLCPPEYTGELCEEKLDFCAQDL 1044
Query: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
NPC H C+ P G+ C C G+VG +C+I
Sbjct: 1045 NPCQHDSKCILTPKGFKCDCTPGYVGEHCDI 1075
Score = 104 bits (259), Expect = 3e-22
Identities = 119/471 (25%), Positives = 186/471 (39%), Gaps = 83/471 (17%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
PC++ C P+ G+ C C G G +C + D C N C +G +
Sbjct: 1046 PCQHDSKCILTPK------------GFKCDCTPGYVGEHCDIDFDDCQDNKCKNG---AH 1090
Query: 112 SSSSSDGYLCICNEGYEGPNCEQALPS-LPATGWTESM-APRQLQPVPATQEPDKILPRS 169
+ + +GY CIC EGY G CE + P LP T ++ Q + EP
Sbjct: 1091 CTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP------- 1143
Query: 170 QATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIR 229
LP +Q + +K+V + + E I ++ ++ + E K
Sbjct: 1144 -ICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGD 1202
Query: 230 QDATASLILLWKVTA---TGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVN 286
+D A + +V A TG S I SV + + G + E+LAL + + V+
Sbjct: 1203 KDHIAVELYRGRVRASYDTGSHPASAI--YSVETI--NDGNFHIVELLALDQSLSLS-VD 1257
Query: 287 DSVTKSIVALRLTLVVKVSTCV-----PGESHANDLECSGKGKCTTKPSEATFSCTCEEQ 341
K I L + + + PG+S+ L G+ T +F
Sbjct: 1258 GGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLR-QAPGQNGT-----SFHGCIRNL 1311
Query: 342 YVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPC 401
Y+ + +++ Q+ P Q LPG E C K+ C
Sbjct: 1312 YINSELQDF---QKVPMQTGI------------------LPGC--EPCHKKV-------C 1341
Query: 402 RNGATCISSLSGFTCQCPEGYFGSACEEKV-DPCASSPCQNNGTCY-VDGVHFTCNCSPG 459
+G SS +GFTC+C EG+ G C+++ DPC + C +GTC ++ ++C C G
Sbjct: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTCLPINAFSYSCKCLEG 1400
Query: 460 FTGPTCAQ---LIDFCALSPCAHGTCR--SVGTSYKCLCDPGYHGLYCEEE 505
G C + L + C C HG CR +G Y C C GY G C+ E
Sbjct: 1401 HGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPY-CECSSGYTGDSCDRE 1450
Score = 101 bits (251), Expect = 3e-21
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 8/122 (6%)
Query: 507 NECLSAPCLNAATCR-DLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC-----DS 560
N CLS PC N TC D V+ Y C C +KG C++ C + C +G TC +
Sbjct: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
Query: 561 DGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
DG CICA GF GE C++++++C+ N C + +C+D N Y C CP + G CE L
Sbjct: 980 DGF--WCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
Query: 621 QW 622
+
Sbjct: 1038 DF 1039
Score = 86.3 bits (212), Expect = 9e-17
Identities = 41/112 (36%), Positives = 51/112 (45%), Gaps = 11/112 (9%)
Query: 22 LLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT 81
LLL + + PV L+ PC + PC+N G C S P Y CT
Sbjct: 896 LLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDF-----------YRCT 944
Query: 82 CPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
CP G G +C + C SNPC HG DG+ CIC +G+EG NCE
Sbjct: 945 CPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
Score = 84.7 bits (208), Expect = 3e-16
Identities = 108/478 (22%), Positives = 175/478 (36%), Gaps = 92/478 (19%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS--NPCHH 105
C C N C G Y+C CP +G C+ D CA NPC H
Sbjct: 1002 CEDNDCENNSTCVD------------GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQH 1049
Query: 106 ---------------------------------GNCSSSS--SSSSDGYLCICNEGYEGP 130
C + + + + +GY CIC EGY G
Sbjct: 1050 DSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGL 1109
Query: 131 NCEQALPS-LPATGWTESM-APRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVE 188
CE + P LP T ++ Q + EP LP +Q + +K+V
Sbjct: 1110 FCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP--------ICQCLPGYQGEKCEKLVS 1161
Query: 189 MKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTA---T 245
+ + E I ++ ++ + E K +D A + +V A T
Sbjct: 1162 VNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDT 1221
Query: 246 GFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVS 305
G S I SV + + G + E+LAL + + V+ K I L +
Sbjct: 1222 GSHPASAI--YSVETI--NDGNFHIVELLALDQSLSLS-VDGGNPKIITNLSKQSTLNFD 1276
Query: 306 T-----CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRK---- 356
+ +PG+S+ L G+ T +F Y+ + +++ +
Sbjct: 1277 SPLYVGGMPGKSNVASLR-QAPGQNGT-----SFHGCIRNLYINSELQDFQKVPMQTGIL 1330
Query: 357 ----PCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKI-DYCILDPCRNGATCISSL 411
PC + + FTC C G+ G LC + D C+ + C +G +
Sbjct: 1331 PGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINA 1390
Query: 412 SGFTCQCPEGYFGSACEEKVD---PCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTC 465
++C+C EG+ G C+E+ D PC + C+ +G C + G+ C CS G+TG +C
Sbjct: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCK-HGKCRLSGLGQPYCECSSGYTGDSC 1447
Score = 83.2 bits (204), Expect = 8e-16
Identities = 84/412 (20%), Positives = 156/412 (37%), Gaps = 68/412 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCA---SNPCH 104
C C+NG CT GY+C CP G SG C+ + P ++PC
Sbjct: 1080 CQDNKCKNGAHCTDAVN------------GYTCICPEGYSGLFCEF-SPPMVLPRTSPCD 1126
Query: 105 HGNCSSSSSS--SSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEP 162
+ +C + + + +C C GY+G CE+ + + +P+
Sbjct: 1127 NFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVS-------VNFINKESYLQIPSA--- 1176
Query: 163 DKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVS----- 217
K+ P++ T+ + T + ++ K D+ + ++ G ++ G S
Sbjct: 1177 -KVRPQTNITLQIATDEDSG---ILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSV 1232
Query: 218 -------------FEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQAS 264
+ Q+ S+ + + L K + F + G +
Sbjct: 1233 ETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGG-----MPGK 1287
Query: 265 GGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGK 324
+ L + F G + + S + V + +PG + C+ G
Sbjct: 1288 SNVASLRQAPGQNGTSFHGCIRNLYINSELQ-DFQKVPMQTGILPGCEPCHKKVCA-HGT 1345
Query: 325 CTTKPSEATFSCTCEEQYVGTFCEEY--DACQRKPCQNNASCIDANEKQDGSNFTCVCLP 382
C S+A F+C C+E ++G C++ D C C + +C+ N +++C CL
Sbjct: 1346 CQPS-SQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPIN----AFSYSCKCLE 1399
Query: 383 GYTGELCQSKIDY---CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKV 431
G+ G LC + D C C++G +S L C+C GY G +C+ ++
Sbjct: 1400 GHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
Score = 70.5 bits (171), Expect = 5e-12
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 472 CALSPCAHGTCR-SVGTSYKCLCDPGYHGLYCEEEYNE-CLSAPCLNAATCRDLVNGYEC 529
C CAHGTC+ S + C C G+ G C++ N+ CL C++ Y C
Sbjct: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
Query: 530 VCLAEYKGTHCELYKD---PCANVSCLNGATCDSDGLNGT-CICAPGFTGEECDIDIN 583
CL + G C+ +D PC + C +G C GL C C+ G+TG+ CD +I+
Sbjct: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGK-CRLSGLGQPYCECSSGYTGDSCDREIS 1452
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/96 (28%), Positives = 40/96 (41%), Gaps = 4/96 (4%)
Query: 526 GYECVCLAEYKGTHCELY-KDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDID--- 581
G+ C C + G C+ DPC C++G + + +C C G G CD +
Sbjct: 1353 GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412
Query: 582 INECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
N C + C HG L C C G+ G +C+
Sbjct: 1413 FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/100 (31%), Positives = 43/100 (43%), Gaps = 16/100 (16%)
Query: 36 PVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC-QLV 94
P+ L PC + C +G C P+ + G++C C G G C Q
Sbjct: 1324 PMQTGILPGCEPCHKKVCAHG-TCQ-----------PSSQAGFTCECQEGWMGPLCDQRT 1371
Query: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
DPC N C HG C ++ S Y C C EG+ G C++
Sbjct: 1372 NDPCLGNKCVHGTCLPINAFS---YSCKCLEGHGGVLCDE 1408
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/74 (32%), Positives = 30/74 (40%), Gaps = 1/74 (1%)
Query: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINE-CDSNPCHHGGSCLDQPNGY 603
+PC C +G S TC C G+ G CD N+ C N C HG Y
Sbjct: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
Query: 604 NCHCPHGWVGANCE 617
+C C G G C+
Sbjct: 1394 SCKCLEGHGGVLCD 1407
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/93 (29%), Positives = 34/93 (36%), Gaps = 18/93 (19%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD---PCASNPC 103
PC C +G C P YSC C G G C D PC + C
Sbjct: 1374 PCLGNKCVHG-TCL-----------PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC 1421
Query: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
HG C S C C+ GY G +C++ +
Sbjct: 1422 KHGKCRLSGLGQP---YCECSSGYTGDSCDREI 1451
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 155 bits (392), Expect = 1e-37
Identities = 107/355 (30%), Positives = 144/355 (40%), Gaps = 16/355 (4%)
Query: 333 TFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGE--LCQ 390
++ CE VGT C + P + +D VC G + E C+
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCE 232
Query: 391 SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD---PCASSPCQNNGTCYV 447
+ L+ G C +S +C P G + V PC +PC N G+C
Sbjct: 233 QPGECRCLEGW-TGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSE 291
Query: 448 DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVG----TSYKCLCDPGYHGLYCE 503
F C C GF G C CA PC +G G ++Y C C PG+ G CE
Sbjct: 292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
Query: 504 EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGL 563
+ + C PC N C DL + C C A + G CE D CA +C NG TC G
Sbjct: 352 KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
Query: 564 NGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE--IHLQ 621
C CA GF G +C + C + PC HGG C +G C C G++GA CE +H
Sbjct: 412 AHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPD 471
Query: 622 WKSGHMAESLTNMP----RHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGS 672
S A P R+ L +G L A + +L+V + R + GS
Sbjct: 472 GASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGS 526
Score = 150 bits (378), Expect = 5e-36
Identities = 73/198 (36%), Positives = 94/198 (47%), Gaps = 6/198 (3%)
Query: 308 VPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD-ACQRKPCQNNASCID 366
VPG + C+ G C+ P +F CTC + G CE C PC N C+
Sbjct: 272 VPGPGPCDGNPCANGGSCSETP--RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVG 329
Query: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSA 426
+ S + C C PG+ G C+ ++D C L PCRNG C+ C+C G+ G
Sbjct: 330 GADPD--SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPR 387
Query: 427 CEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSV 485
CE +D CA C N GTC G C+C+ GF G C + D CA PCAH G C +
Sbjct: 388 CEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAH 447
Query: 486 GTSYKCLCDPGYHGLYCE 503
+ C C PGY G CE
Sbjct: 448 FSGLVCACAPGYMGARCE 465
Score = 80.1 bits (196), Expect = 7e-15
Identities = 37/107 (34%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 28 PRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGIS 87
PRG S A P PGPC PC NGG C+ P + CTCP G
Sbjct: 260 PRGPSSATTGCLVP--GPGPCDGNPCANGGSCSETPR------------SFECTCPRGFY 305
Query: 88 GANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
G C++ CA PC +G + Y+C C G++G NCE+
Sbjct: 306 GLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEK 352
Score = 64.7 bits (156), Expect = 3e-10
Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 12/89 (13%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA PC NGG+C +PD Y C CP G G+NC+ D C+ PC +G
Sbjct: 316 CADGPCFNGGLCVGGADPDS---------AYICHCPPGFQGSNCEKRVDRCSLQPCRNGG 366
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+ C C G+ GP CE L
Sbjct: 367 LCLDLGHA---LRCRCRAGFAGPRCEHDL 392
Score = 64.3 bits (155), Expect = 4e-10
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 25/102 (24%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
CA + C NGG C G + C+C G G +C+ ADPCA+ PC H G
Sbjct: 395 CAGRACANGGTCVE------------GGGAHRCSCALGFGGRDCRERADPCAARPCAHGG 442
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE--------QALPSLP 140
C + S G +C C GY G CE ALP+ P
Sbjct: 443 RCYAHFS----GLVCACAPGYMGARCEFPVHPDGASALPAAP 480
Score = 50.1 bits (118), Expect = 8e-06
Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ QPCRNGG+C D H C C AG +G C+ D CA C +G
Sbjct: 357 CSLQPCRNGGLCL-----DLGH-------ALRCRCRAGFAGPRCEHDLDDCAGRACANG- 403
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ + C C G+ G +C +
Sbjct: 404 --GTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/51 (35%), Positives = 21/51 (41%), Gaps = 12/51 (23%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP 97
PCAA+PC +GG C A G C C G GA C+ P
Sbjct: 432 PCAARPCAHGGRCY------------AHFSGLVCACAPGYMGARCEFPVHP 470
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 155 bits (392), Expect = 1e-37
Identities = 107/355 (30%), Positives = 144/355 (40%), Gaps = 16/355 (4%)
Query: 333 TFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGE--LCQ 390
++ CE VGT C + P + +D VC G + E C+
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCE 232
Query: 391 SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD---PCASSPCQNNGTCYV 447
+ L+ G C +S +C P G + V PC +PC N G+C
Sbjct: 233 QPGECRCLEGW-TGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSE 291
Query: 448 DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVG----TSYKCLCDPGYHGLYCE 503
F C C GF G C CA PC +G G ++Y C C PG+ G CE
Sbjct: 292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
Query: 504 EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGL 563
+ + C PC N C DL + C C A + G CE D CA +C NG TC G
Sbjct: 352 KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
Query: 564 NGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE--IHLQ 621
C CA GF G +C + C + PC HGG C +G C C G++GA CE +H
Sbjct: 412 AHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPD 471
Query: 622 WKSGHMAESLTNMP----RHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGS 672
S A P R+ L +G L A + +L+V + R + GS
Sbjct: 472 GASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGS 526
Score = 150 bits (378), Expect = 5e-36
Identities = 73/198 (36%), Positives = 94/198 (47%), Gaps = 6/198 (3%)
Query: 308 VPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD-ACQRKPCQNNASCID 366
VPG + C+ G C+ P +F CTC + G CE C PC N C+
Sbjct: 272 VPGPGPCDGNPCANGGSCSETP--RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVG 329
Query: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSA 426
+ S + C C PG+ G C+ ++D C L PCRNG C+ C+C G+ G
Sbjct: 330 GADPD--SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPR 387
Query: 427 CEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSV 485
CE +D CA C N GTC G C+C+ GF G C + D CA PCAH G C +
Sbjct: 388 CEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAH 447
Query: 486 GTSYKCLCDPGYHGLYCE 503
+ C C PGY G CE
Sbjct: 448 FSGLVCACAPGYMGARCE 465
Score = 80.1 bits (196), Expect = 7e-15
Identities = 37/107 (34%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 28 PRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGIS 87
PRG S A P PGPC PC NGG C+ P + CTCP G
Sbjct: 260 PRGPSSATTGCLVP--GPGPCDGNPCANGGSCSETPR------------SFECTCPRGFY 305
Query: 88 GANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
G C++ CA PC +G + Y+C C G++G NCE+
Sbjct: 306 GLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEK 352
Score = 64.7 bits (156), Expect = 3e-10
Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 12/89 (13%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
CA PC NGG+C +PD Y C CP G G+NC+ D C+ PC +G
Sbjct: 316 CADGPCFNGGLCVGGADPDS---------AYICHCPPGFQGSNCEKRVDRCSLQPCRNGG 366
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+ C C G+ GP CE L
Sbjct: 367 LCLDLGHA---LRCRCRAGFAGPRCEHDL 392
Score = 64.3 bits (155), Expect = 4e-10
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 25/102 (24%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
CA + C NGG C G + C+C G G +C+ ADPCA+ PC H G
Sbjct: 395 CAGRACANGGTCVE------------GGGAHRCSCALGFGGRDCRERADPCAARPCAHGG 442
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE--------QALPSLP 140
C + S G +C C GY G CE ALP+ P
Sbjct: 443 RCYAHFS----GLVCACAPGYMGARCEFPVHPDGASALPAAP 480
Score = 50.1 bits (118), Expect = 8e-06
Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 15/87 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C+ QPCRNGG+C D H C C AG +G C+ D CA C +G
Sbjct: 357 CSLQPCRNGGLCL-----DLGH-------ALRCRCRAGFAGPRCEHDLDDCAGRACANG- 403
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ + C C G+ G +C +
Sbjct: 404 --GTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/51 (35%), Positives = 21/51 (41%), Gaps = 12/51 (23%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP 97
PCAA+PC +GG C A G C C G GA C+ P
Sbjct: 432 PCAARPCAHGGRCY------------AHFSGLVCACAPGYMGARCEFPVHP 470
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 149 bits (377), Expect = 7e-36
Identities = 78/215 (36%), Positives = 109/215 (50%), Gaps = 10/215 (4%)
Query: 336 CTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDY 395
C C E ++G +C+ D C++ CQN +C+ + TC C G+TGE CQ +
Sbjct: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCV---AQAMLGKATCRCASGFTGEDCQYSTSH 68
Query: 396 -CILD-PCRNGATC-ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
C + PC NG TC + S + C C G+ G C+ D C S PC N TC F
Sbjct: 69 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQF 127
Query: 453 TCNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECL 510
+C C GFTG C ++ C + C HG TC ++ SY+C C G+ G YC+ Y C
Sbjct: 128 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCA 187
Query: 511 SAPCLNAATCRDLVN-GYECVCLAEYKGTHCELYK 544
+PC+N TCR + +EC CL E EL++
Sbjct: 188 PSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWE 222
Score = 147 bits (372), Expect = 3e-35
Identities = 78/202 (38%), Positives = 103/202 (50%), Gaps = 10/202 (4%)
Query: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISS--LSGFTCQCPEGYFGSACEEKVD-PC 434
C C G+ GE CQ + D C + C+NG TC++ L TC+C G+ G C+ PC
Sbjct: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
Query: 435 -ASSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKC 491
S PC N GTC++ + C C GFTG C Q D C PCA+G TC +V + C
Sbjct: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSC 129
Query: 492 LCDPGYHGLYCEEEYNEC-LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV 550
C G+ G CE + NEC + C + TC +L Y+C CL + G +C+ PCA
Sbjct: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
Query: 551 SCLNGATCDSDG-LNGTCICAP 571
C+NG TC G C C P
Sbjct: 190 PCVNGGTCRQTGDFTFECNCLP 211
Score = 144 bits (364), Expect = 2e-34
Identities = 73/206 (35%), Positives = 97/206 (47%), Gaps = 41/206 (19%)
Query: 416 CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV--HFTCNCSPGFTGPTCAQLIDFCA 473
C+CPEG+ G C+ + DPC + CQN GTC + TC C+ GFTG C
Sbjct: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC-------- 62
Query: 474 LSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCL 532
TS+ C +S PCLN TC L YEC C
Sbjct: 63 ----------QYSTSHPCF-----------------VSRPCLNGGTCHMLSRDTYECTCQ 95
Query: 533 AEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECD-SNPCH 591
+ G C+ + D C + C NG+TC + +C C GFTG++C+ D+NECD C
Sbjct: 96 VGFTGKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQ 154
Query: 592 HGGSCLDQPNGYNCHCPHGWVGANCE 617
HGG+CL+ P Y C C G+ G C+
Sbjct: 155 HGGTCLNLPGSYQCQCLQGFTGQYCD 180
Score = 114 bits (285), Expect = 3e-25
Identities = 61/183 (33%), Positives = 85/183 (46%), Gaps = 11/183 (6%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE---EYDACQRKPCQNNASCIDANEKQDGSN 375
C G C + +C C + G C+ + +PC N +C
Sbjct: 34 CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC----HMLSRDT 89
Query: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC- 434
+ C C G+TG+ CQ D C+ PC NG+TC + + F+C+C G+ G CE V+ C
Sbjct: 90 YECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECD 148
Query: 435 ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGT-SYKCL 492
CQ+ GTC + C C GFTG C L CA SPC + GTCR G +++C
Sbjct: 149 IPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECN 208
Query: 493 CDP 495
C P
Sbjct: 209 CLP 211
Score = 53.9 bits (128), Expect = 5e-07
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 16/92 (17%)
Query: 43 SAPGPC-AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
S PC ++PC NGG C Y CTC G +G CQ D C S+
Sbjct: 65 STSHPCFVSRPCLNGGTCHM-----------LSRDTYECTCQVGFTGKECQW-TDACLSH 112
Query: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
PC +G S+ ++ ++ + C C G+ G CE
Sbjct: 113 PCANG---STCTTVANQFSCKCLTGFTGQKCE 141
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/96 (27%), Positives = 38/96 (39%), Gaps = 17/96 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC-ASNPCHHG 106
C + PC NG CT+ +SC C G +G C+ + C C HG
Sbjct: 109 CLSHPCANGSTCTTVANQ------------FSCKCLTGFTGQKCETDVNECDIPGHCQHG 156
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQA-LPSLPA 141
+ S Y C C +G+ G C+ +P P+
Sbjct: 157 GTCLNLPGS---YQCQCLQGFTGQYCDSLYVPCAPS 189
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 77 GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
GY C CP G G CQ DPC N C +G + + C C G+ G +C+
Sbjct: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQ 63
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 144 bits (362), Expect = 4e-34
Identities = 77/215 (35%), Positives = 106/215 (49%), Gaps = 17/215 (7%)
Query: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL 474
+C+C G+ G CE C P +GTC+ + C C G+ G C + C
Sbjct: 45 SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTT 97
Query: 475 -SPCAHG--TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA--PCLNAATCRD---LVNG 526
SPC +G G Y C+C PG+HG CE + C A PC N C+D
Sbjct: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
Query: 527 YECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINEC 585
+ C CL + G CE+ D C C NGATC DG+N +C+C GF G C I++++C
Sbjct: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDC 216
Query: 586 DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
S PC G C D+ + ++C CP G+ G CE+ L
Sbjct: 217 ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 135 bits (339), Expect = 2e-31
Identities = 74/206 (35%), Positives = 93/206 (45%), Gaps = 14/206 (6%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQNNASC 364
C PG + C C + C C + G FC+ E+ + PCQN C
Sbjct: 48 CDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCIL--DPCRNGATCISSLS---GFTCQCP 419
+ G + CVCLPG+ G C+ K C PCRNG C FTC+C
Sbjct: 108 M----YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL 163
Query: 420 EGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCA 478
G+ G+ CE VD C PC N TC +DG++ F+C C GF G C +D CA PC
Sbjct: 164 VGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
Query: 479 HGT-CRSVGTSYKCLCDPGYHGLYCE 503
G CR + CLC GY G CE
Sbjct: 223 RGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 63.5 bits (153), Expect = 7e-10
Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 16/113 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +PC NG C G +SC CP G +G C + D CAS PC G
Sbjct: 178 CLMRPCANGATCLD------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP-SLPATGWTESMAPRQLQPVPAT 159
D C+C GY G CE LP P T + P VPAT
Sbjct: 226 RCRDRVHDFD---CLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPAT 275
Score = 50.1 bits (118), Expect = 8e-06
Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 14/89 (15%)
Query: 48 CAAQ-PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCH 104
C Q PC+NGG C G Y C C G G +C+ A PC A +PC
Sbjct: 95 CTTQSPCQNGGQCMYD-----------GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+G + + C C G+ G CE
Sbjct: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCE 172
Score = 38.1 bits (87), Expect = 0.030
Identities = 26/74 (35%), Positives = 34/74 (45%), Gaps = 12/74 (16%)
Query: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNP-CHHGGSCLDQPNGY 603
D C++ L C DG +C C PG+ G C+ C P C H G+C QP +
Sbjct: 27 DDCSSHCDLAHGCCAPDG---SCRCDPGWEGLHCE----RCVRMPGCQH-GTC-HQP--W 75
Query: 604 NCHCPHGWVGANCE 617
C C GW G C+
Sbjct: 76 QCICHSGWAGKFCD 89
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/129 (26%), Positives = 48/129 (37%), Gaps = 19/129 (14%)
Query: 17 LALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQH-----PA 71
L LL +LGA PV A S+ A C G C P + H
Sbjct: 10 LVCLLCILGAP------GQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
Query: 72 PAGEPG-----YSCTCPAGISGANCQLVADPCAS-NPCHHGNCSSSSSSSSDGYLCICNE 125
P + G + C C +G +G C C + +PC +G Y C+C
Sbjct: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGE--YHCVCLP 121
Query: 126 GYEGPNCEQ 134
G+ G +CE+
Sbjct: 122 GFHGRDCER 130
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 9/67 (13%)
Query: 72 PAGEPGYSCTCPAGISGANCQLV-ADPCASN-PCHHGNCSSSSSSSSDGYLCICNEGYEG 129
P+G C I GA Q V AD C+S+ HG C+ S C C+ G+EG
Sbjct: 2 PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGS-------CRCDPGWEG 54
Query: 130 PNCEQAL 136
+CE+ +
Sbjct: 55 LHCERCV 61
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 144 bits (362), Expect = 4e-34
Identities = 77/215 (35%), Positives = 106/215 (49%), Gaps = 17/215 (7%)
Query: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL 474
+C+C G+ G CE C P +GTC+ + C C G+ G C + C
Sbjct: 45 SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTT 97
Query: 475 -SPCAHG--TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA--PCLNAATCRD---LVNG 526
SPC +G G Y C+C PG+HG CE + C A PC N C+D
Sbjct: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
Query: 527 YECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINEC 585
+ C CL + G CE+ D C C NGATC DG+N +C+C GF G C I++++C
Sbjct: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDC 216
Query: 586 DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
S PC G C D+ + ++C CP G+ G CE+ L
Sbjct: 217 ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 135 bits (339), Expect = 2e-31
Identities = 74/206 (35%), Positives = 93/206 (45%), Gaps = 14/206 (6%)
Query: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQNNASC 364
C PG + C C + C C + G FC+ E+ + PCQN C
Sbjct: 48 CDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
Query: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCIL--DPCRNGATCISSLS---GFTCQCP 419
+ G + CVCLPG+ G C+ K C PCRNG C FTC+C
Sbjct: 108 M----YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL 163
Query: 420 EGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCA 478
G+ G+ CE VD C PC N TC +DG++ F+C C GF G C +D CA PC
Sbjct: 164 VGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
Query: 479 HGT-CRSVGTSYKCLCDPGYHGLYCE 503
G CR + CLC GY G CE
Sbjct: 223 RGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 63.5 bits (153), Expect = 7e-10
Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 16/113 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C +PC NG C G +SC CP G +G C + D CAS PC G
Sbjct: 178 CLMRPCANGATCLD------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP-SLPATGWTESMAPRQLQPVPAT 159
D C+C GY G CE LP P T + P VPAT
Sbjct: 226 RCRDRVHDFD---CLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPAT 275
Score = 50.1 bits (118), Expect = 8e-06
Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 14/89 (15%)
Query: 48 CAAQ-PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCH 104
C Q PC+NGG C G Y C C G G +C+ A PC A +PC
Sbjct: 95 CTTQSPCQNGGQCMYD-----------GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
Query: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
+G + + C C G+ G CE
Sbjct: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCE 172
Score = 38.1 bits (87), Expect = 0.030
Identities = 26/74 (35%), Positives = 34/74 (45%), Gaps = 12/74 (16%)
Query: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNP-CHHGGSCLDQPNGY 603
D C++ L C DG +C C PG+ G C+ C P C H G+C QP +
Sbjct: 27 DDCSSHCDLAHGCCAPDG---SCRCDPGWEGLHCE----RCVRMPGCQH-GTC-HQP--W 75
Query: 604 NCHCPHGWVGANCE 617
C C GW G C+
Sbjct: 76 QCICHSGWAGKFCD 89
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/129 (26%), Positives = 48/129 (37%), Gaps = 19/129 (14%)
Query: 17 LALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQH-----PA 71
L LL +LGA PV A S+ A C G C P + H
Sbjct: 10 LVCLLCILGAP------GQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
Query: 72 PAGEPG-----YSCTCPAGISGANCQLVADPCAS-NPCHHGNCSSSSSSSSDGYLCICNE 125
P + G + C C +G +G C C + +PC +G Y C+C
Sbjct: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGE--YHCVCLP 121
Query: 126 GYEGPNCEQ 134
G+ G +CE+
Sbjct: 122 GFHGRDCER 130
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 9/67 (13%)
Query: 72 PAGEPGYSCTCPAGISGANCQLV-ADPCASN-PCHHGNCSSSSSSSSDGYLCICNEGYEG 129
P+G C I GA Q V AD C+S+ HG C+ S C C+ G+EG
Sbjct: 2 PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGS-------CRCDPGWEG 54
Query: 130 PNCEQAL 136
+CE+ +
Sbjct: 55 LHCERCV 61
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 143 bits (360), Expect = 7e-34
Identities = 81/230 (35%), Positives = 109/230 (47%), Gaps = 22/230 (9%)
Query: 362 ASCIDANEKQDG---SNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFT--C 416
A C A Q+G + C C PG+ G LC D C+ P C+ L G C
Sbjct: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSP-----GCLHGLCGEPGQC 74
Query: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQLIDFCAL- 474
C +G+ G C+ V C+S+PC NNGTC +D + C+C+PG++G C + C +
Sbjct: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
Query: 475 -SPCAHG-TC---RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529
SPC HG TC + CLC PG+ G +CE N C PC N C D+ + C
Sbjct: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
Query: 530 VCLAEYKGTHCELYKDPCANVSCLNGATC-DSDGLNGTCICAPGFTGEEC 578
C A + C CA+ C NG TC ++ C+C P FTG C
Sbjct: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 142 bits (357), Expect = 1e-33
Identities = 74/201 (36%), Positives = 95/201 (47%), Gaps = 24/201 (11%)
Query: 423 FGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-CAHGT 481
+G+ C +P NG C D V C C PG+ GP C Q C SP C HG
Sbjct: 22 YGAECFPACNP-------QNGFCEDDNV---CRCQPGWQGPLCDQ----CVTSPGCLHGL 67
Query: 482 CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCLAEYKGTHC 540
C G +C+C G+ G C+ + C SAPC N TC L +G YEC C Y G C
Sbjct: 68 CGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC 124
Query: 541 ELYKDPCA--NVSCLNGATCDSD---GLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595
+ PC C +G TC D + +C+C PGF+G C+I N C NPC + G
Sbjct: 125 QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGV 184
Query: 596 CLDQPNGYNCHCPHGWVGANC 616
C D + C CP G++ C
Sbjct: 185 CTDIGGDFRCRCPAGFIDKTC 205
Score = 138 bits (348), Expect = 2e-32
Identities = 72/207 (34%), Positives = 102/207 (49%), Gaps = 12/207 (5%)
Query: 304 VSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNA 362
V C PG +C C C C + + G C+ + AC PC NN
Sbjct: 42 VCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNG 101
Query: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD--PCRNGATCISS---LSGFTCQ 417
+C+ D + C C PGY+G+ CQ K C+++ PC++G TC+ S +C
Sbjct: 102 TCVSL----DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCL 157
Query: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC 477
CP G+ G+ CE + C +PC+N+G C G F C C GF TC++ + CA SPC
Sbjct: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
Query: 478 AH-GTC-RSVGTSYKCLCDPGYHGLYC 502
+ GTC + SY+CLC P + GL C
Sbjct: 218 QNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 124 bits (311), Expect = 3e-28
Identities = 67/209 (32%), Positives = 98/209 (46%), Gaps = 15/209 (7%)
Query: 416 CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALS 475
C+C G+ G C D C +SP +G C G C C+ G+ G C + + C+ +
Sbjct: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
Query: 476 PCAH-GTCRSVGTS-YKCLCDPGYHGLYCEEEYNECL--SAPCLNAATCRD---LVNGYE 528
PCA+ GTC S+ Y+C C PGY G C+++ C+ +PC + TC D +
Sbjct: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
Query: 529 CVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSN 588
C+C + G CE+ + C C N C G + C C GF + C + C S+
Sbjct: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
Query: 589 PCHHGGSCLDQPN-GYNCHCPHGWVGANC 616
PC +GG+CL Y C C + G C
Sbjct: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 117 bits (292), Expect = 5e-26
Identities = 67/218 (30%), Positives = 99/218 (45%), Gaps = 13/218 (5%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA---CQRKPCQNNASCIDANEKQDGSN 375
C+ G C + + + C+C Y G C++ D PCQ+ +C+D ++ S+
Sbjct: 97 CANNGTCVSL-DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD--DEGRASH 153
Query: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
+C+C PG++G C+ + C +PC N C F C+CP G+ C V CA
Sbjct: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
Query: 436 SSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRS-VGTSYKCLC 493
SSPCQN GTC V + C C P FTG TC + ALSP S G +Y+
Sbjct: 214 SSPCQNGGTCLQHTQVSYECLCKPEFTGLTC---VKKRALSPQQVTRLPSGYGLAYR--L 268
Query: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531
PG H L ++ + L L+ + +C
Sbjct: 269 TPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAIC 306
Score = 83.6 bits (205), Expect = 6e-16
Identities = 45/135 (33%), Positives = 70/135 (51%), Gaps = 15/135 (11%)
Query: 491 CLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV 550
C C PG+ G C++ C+++P C + +C+C + G C+ C++
Sbjct: 43 CRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
Query: 551 SCLNGATCDS--DGLNGTCICAPGFTGEECDIDINEC--DSNPCHHGGSCLD---QPNGY 603
C N TC S DGL C CAPG++G++C C + +PC HGG+C+D + +
Sbjct: 96 PCANNGTCVSLDDGLY-ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
Query: 604 NCHCPHGWVGANCEI 618
+C CP G+ G CEI
Sbjct: 155 SCLCPPGFSGNFCEI 169
Score = 57.0 bits (136), Expect = 6e-08
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 13/88 (14%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN--PCHH 105
C++ PC N G C S + Y C+C G SG +CQ PC N PC H
Sbjct: 92 CSSAPCANNGTCVS-----------LDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
G + C+C G+ G CE
Sbjct: 141 GGTCVDDEGRASHASCLCPPGFSGNFCE 168
Score = 52.4 bits (124), Expect = 2e-06
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 16/92 (17%)
Query: 46 GPCA--AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103
GPC PC++GG C E H SC CP G SG C++VA+ C NPC
Sbjct: 129 GPCVINGSPCQHGGTCVD-DEGRASHA--------SCLCPPGFSGNFCEIVANSCTPNPC 179
Query: 104 HH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
+ G C+ + C C G+ C +
Sbjct: 180 ENDGVCTDIGGD----FRCRCPAGFIDKTCSR 207
Score = 50.8 bits (120), Expect = 4e-06
Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 24/111 (21%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC N GVCT G+ + C CPAG C CAS+PC +G
Sbjct: 174 CTPNPCENDGVCTDI----------GGD--FRCRCPAGFIDKTCSRPVTNCASSPCQNGG 221
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPA 158
+ S Y C+C + G C + +++P+Q+ +P+
Sbjct: 222 TCLQHTQVS--YECLCKPEFTGLTCVK----------KRALSPQQVTRLPS 260
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/89 (33%), Positives = 37/89 (41%), Gaps = 7/89 (7%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
C QP G +C GEPG C C G G C C+S PC ++G
Sbjct: 43 CRCQPGWQGPLCDQCVTSPGCLHGLCGEPG-QCICTDGWDGELCDRDVRACSSAPCANNG 101
Query: 107 NCSSSSSSSSDG-YLCICNEGYEGPNCEQ 134
C S DG Y C C GY G +C++
Sbjct: 102 TC----VSLDDGLYECSCAPGYSGKDCQK 126
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 142 bits (359), Expect = 9e-34
Identities = 90/283 (31%), Positives = 126/283 (44%), Gaps = 45/283 (15%)
Query: 336 CTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDY 395
C C+ Y+G+ C+ A C+N+ CI N C CLPG+ G C ++
Sbjct: 1314 CKCKPGYIGSNCQT--ALCDPDCKNHGKCIKPN--------ICQCLPGHGGATCDE--EH 1361
Query: 396 CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCN 455
C PC++G TC L+G C CP G+ G CE V + C+N G C + C
Sbjct: 1362 CN-PPCQHGGTC---LAGNLCTCPYGFVGPRCETMV---CNRHCENGGQCLTPDI---CQ 1411
Query: 456 CSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCL 515
C PG+ GPTC+ + C G+C T CLC G+ G +C+ N PC
Sbjct: 1412 CKPGWYGPTCSTAL--CDPVCLNGGSCNKPNT---CLCPNGFFGEHCQ---NAFCHPPCK 1463
Query: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTG 575
N C + CVC Y G ++ + +C+NG C TC C G++G
Sbjct: 1464 NGGHC---MRNNVCVCREGYTGRR---FQKSICDPTCMNGGKCVGPS---TCSCPSGWSG 1514
Query: 576 EECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEI 618
+ C+ I C C +GG C+ CHCP W G C+I
Sbjct: 1515 KRCNTPI--C-LQKCKNGGECIAPSI---CHCPSSWEGVRCQI 1551
Score = 112 bits (281), Expect = 9e-25
Identities = 88/299 (29%), Positives = 120/299 (40%), Gaps = 66/299 (22%)
Query: 358 CQNNASCIDANEKQDGSN-FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTC 416
C N SC+ GS + CVCLPG+ G LC+ I C +PC G + IS ++C
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLG-SYISGFHSYSC 1241
Query: 417 QCP-----EGYF---------------GSACEEKVDPCASS------------------P 438
CP E F S +E+ D A P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301
Query: 439 CQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYH 498
C + C + C C PG+ G C + C HG C C C PG+
Sbjct: 1302 CGKSRECVAPNI---CKCKPGYIGSNCQTAL--CDPDCKNHGKCIKPNI---CQCLPGHG 1353
Query: 499 GLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC 558
G C+EE+ + PC + TC + G C C + G CE N C NG C
Sbjct: 1354 GATCDEEH---CNPPCQHGGTC---LAGNLCTCPYGFVGPRCETM---VCNRHCENGGQC 1404
Query: 559 DSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
+ + C C PG+ G C + CD C +GGSC ++PN C CP+G+ G +C+
Sbjct: 1405 LTPDI---CQCKPGWYGPTCSTAL--CDP-VCLNGGSC-NKPN--TCLCPNGFFGEHCQ 1454
Score = 85.1 bits (209), Expect = 2e-16
Identities = 72/266 (27%), Positives = 95/266 (35%), Gaps = 69/266 (25%)
Query: 401 CRNGATCISSL-----SG-FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FT 453
C NG +C+S SG + C C G+ GS CE + C S+PC Y+ G H ++
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGS--YISGFHSYS 1240
Query: 454 CNCSPGF---------------------------------------TGPTCAQLIDFCAL 474
C+C P PT C
Sbjct: 1241 CDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKY 1300
Query: 475 SPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAE 534
PC G R C C PGY G C+ C N C + C CL
Sbjct: 1301 -PC--GKSRECVAPNICKCKPGYIGSNCQ---TALCDPDCKNHGKC---IKPNICQCLPG 1351
Query: 535 YKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGG 594
+ G C+ ++ C N C +G TC + L C C GF G C+ + C+ + C +GG
Sbjct: 1352 HGGATCD--EEHC-NPPCQHGGTCLAGNL---CTCPYGFVGPRCETMV--CNRH-CENGG 1402
Query: 595 SCLDQPNGYNCHCPHGWVGANCEIHL 620
CL C C GW G C L
Sbjct: 1403 QCLTPDI---CQCKPGWYGPTCSTAL 1425
Score = 80.5 bits (197), Expect = 5e-15
Identities = 77/275 (28%), Positives = 99/275 (36%), Gaps = 74/275 (26%)
Query: 304 VSTCVPG-------ESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRK 356
+ C+PG E H N C G C A CTC +VG CE C R
Sbjct: 1345 ICQCLPGHGGATCDEEHCNP-PCQHGGTCL-----AGNLCTCPYGFVGPRCETM-VCNRH 1397
Query: 357 PCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP-CRNGATCISSLSGFT 415
C+N C+ + C C PG+ G C + + DP C NG +C T
Sbjct: 1398 -CENGGQCLTPD--------ICQCKPGWYGPTCST----ALCDPVCLNGGSCNKPN---T 1441
Query: 416 CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALS 475
C CP G+FG C+ PC+N G C + V C C G+TG + I C +
Sbjct: 1442 CLCPNGFFGEHCQNAF---CHPPCKNGGHCMRNNV---CVCREGYTGRRFQKSI--CDPT 1493
Query: 476 PCAHGTCRSVGTSYKCLCDPGYHGLYCE--------EEYNECLSAP-------------- 513
G C VG S C C G+ G C + EC++
Sbjct: 1494 CMNGGKC--VGPS-TCSCPSGWSGKRCNTPICLQKCKNGGECIAPSICHCPSSWEGVRCQ 1550
Query: 514 -------CLNAATCRDLVNGYECVCLAEYKGTHCE 541
CL C + C C EY G CE
Sbjct: 1551 IPICNPKCLYGGRC---IFPNVCSCRTEYSGVKCE 1582
Score = 74.7 bits (182), Expect = 3e-13
Identities = 69/221 (31%), Positives = 85/221 (38%), Gaps = 49/221 (22%)
Query: 436 SSPCQNNGTCYVD-------GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTS 488
S C N G+C D GV+ C C PGF G C I C +PC G+ S S
Sbjct: 1180 SCDCLNGGSCVSDRNFSPGSGVYL-CVCLPGFHGSLCEVDISGCQSNPCGLGSYISGFHS 1238
Query: 489 YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE------- 541
Y C C P L E ++ + + VN E A+ + H +
Sbjct: 1239 YSCDCPP---ELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAF 1295
Query: 542 -LYKDPCAN---------VSCLNG--------ATCDSDGLN-GTCI------CAPGFTGE 576
+ K PC C G A CD D N G CI C PG G
Sbjct: 1296 TICKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGA 1355
Query: 577 ECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
CD E + PC HGG+CL G C CP+G+VG CE
Sbjct: 1356 TCD---EEHCNPPCQHGGTCL---AGNLCTCPYGFVGPRCE 1390
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/120 (27%), Positives = 47/120 (39%), Gaps = 11/120 (9%)
Query: 44 APGPCAAQPCRNGGVC-TSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP 102
AP C +P G C T+ +PD ++ +P C C G GA C + + P
Sbjct: 1310 APNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNI-CQCLPGHGGATCD---EEHCNPP 1365
Query: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEP 162
C HG + G LC C G+ GP CE + + + + P Q P P
Sbjct: 1366 CQHGGTCLA------GNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGP 1419
Score = 43.1 bits (100), Expect = 0.001
Identities = 43/169 (25%), Positives = 57/169 (33%), Gaps = 63/169 (37%)
Query: 316 DLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDAN-----EK 370
D C G C KP+ +C C + G C+ +A PC+N C+ N E
Sbjct: 1427 DPVCLNGGSCN-KPN----TCLCPNGFFGEHCQ--NAFCHPPCKNGGHCMRNNVCVCREG 1479
Query: 371 QDGSNF-------------------TCVCLPGYTGELCQSKIDYCILDPCRNGATCI--- 408
G F TC C G++G+ C + I L C+NG CI
Sbjct: 1480 YTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPI---CLQKCKNGGECIAPS 1536
Query: 409 -----SSLSGFTCQ---------------------CPEGYFGSACEEKV 431
SS G CQ C Y G CE+K+
Sbjct: 1537 ICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCEKKI 1585
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/71 (35%), Positives = 29/71 (40%), Gaps = 10/71 (14%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSS 112
C NGG C S P G Y C C G G+ C++ C SNPC G+ S
Sbjct: 1183 CLNGGSCVSDRNFSP------GSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGF 1236
Query: 113 SSSSDGYLCIC 123
S Y C C
Sbjct: 1237 HS----YSCDC 1243
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/85 (28%), Positives = 34/85 (40%), Gaps = 24/85 (28%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
PC++GG C + G CTCP G G C+ + C + + G C +
Sbjct: 1365 PCQHGGTCLA---------------GNLCTCPYGFVGPRCETMV--CNRHCENGGQCLTP 1407
Query: 112 SSSSSDGYLCICNEGYEGPNCEQAL 136
+C C G+ GP C AL
Sbjct: 1408 D-------ICQCKPGWYGPTCSTAL 1425
Score = 37.4 bits (85), Expect = 0.050
Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 13/94 (13%)
Query: 45 PGPCAAQPCRNGGVC-TSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103
P C +P G C T+ +P + +P +C CP G G +CQ + PC
Sbjct: 1407 PDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPN-TCLCPNGFFGEHCQ---NAFCHPPC 1462
Query: 104 HH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+ G+C ++ +C+C EGY G ++++
Sbjct: 1463 KNGGHCMRNN-------VCVCREGYTGRRFQKSI 1489
Score = 35.8 bits (81), Expect = 0.15
Identities = 25/91 (27%), Positives = 35/91 (38%), Gaps = 26/91 (28%)
Query: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HH 105
P Q C+NGG C AP+ C CP+ G CQ+ P + C +
Sbjct: 1520 PICLQKCKNGGECI----------APS-----ICHCPSSWEGVRCQI---PICNPKCLYG 1561
Query: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
G C + +C C Y G CE+ +
Sbjct: 1562 GRCIFPN-------VCSCRTEYSGVKCEKKI 1585
Score = 33.5 bits (75), Expect = 0.73
Identities = 27/101 (26%), Positives = 38/101 (37%), Gaps = 30/101 (29%)
Query: 52 PCRNGG------VCTSRP------------EPDPQHPAPAGEPGYSCTCPAGISGANCQL 93
PC+NGG VC R +P + P +C+CP+G SG C
Sbjct: 1461 PCKNGGHCMRNNVCVCREGYTGRRFQKSICDPTCMNGGKCVGPS-TCSCPSGWSGKRCN- 1518
Query: 94 VADPCASNPCHH-GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
P C + G C + S +C C +EG C+
Sbjct: 1519 --TPICLQKCKNGGECIAPS-------ICHCPSSWEGVRCQ 1550
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 141 bits (356), Expect = 2e-33
Identities = 112/365 (30%), Positives = 153/365 (41%), Gaps = 81/365 (22%)
Query: 310 GESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA-------CQRK-PCQNN 361
G +N +C C + T +C C + G CEE A CQ C++
Sbjct: 139 GPHCSNRCQCQNGALC----NPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHG 194
Query: 362 ASCIDANEKQDGSNFTCVCLPGYTGELCQ------SKIDYCILD-PCRNGATCISSLSGF 414
ASC D C+C PGYTG C+ S +C L PC+NG TC ++G
Sbjct: 195 ASC-------DPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTC-HHITG- 245
Query: 415 TCQCPEGYFGSACEEKVDP------CASS-PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQ 467
C CP G+ G+ C + P C+ PC + G C D V C+C+ G+ G C +
Sbjct: 246 ECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC--DHVTGQCHCTAGYMGDRCQE 303
Query: 468 LIDFCALS-PCA-HGTCRSVG----TSYKCLCDPGYHGLYCEEEY--------------- 506
F + C+ H C + G T+ C C+PGY G C+E
Sbjct: 304 ECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCP 363
Query: 507 ----NECLSAPCLNAATCRDLVNGYEC--VCLAEYKGTHCELYKDPCANVSCLNGATCDS 560
N P A TC+ +G+ C C Y G C+L PC +C NGA C S
Sbjct: 364 CDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQL---PC---TCQNGADCHS 417
Query: 561 DGLNGTCICAPGFTGEECDIDINECDSNP-------CHHGGSCLDQPNGYNCHCPHGWVG 613
+ G C CAPGF GE C + P C++GG+C P +C C GW G
Sbjct: 418 --ITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTC--SPVDGSCTCKEGWQG 473
Query: 614 ANCEI 618
+C +
Sbjct: 474 LDCTL 478
Score = 134 bits (337), Expect = 3e-31
Identities = 105/368 (28%), Positives = 146/368 (39%), Gaps = 78/368 (21%)
Query: 307 CVPGESHANDLE----CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA-------CQ- 354
C PG +H + C C + E C C Y G +CEE C+
Sbjct: 176 CAPG-THGKGCQLPCQCRHGASCDPRAGE----CLCAPGYTGVYCEELCPPGSHGAHCEL 230
Query: 355 RKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKI------DYCILD-PCRNGATC 407
R PCQN +C + C C PG+TG +C C D PC +G C
Sbjct: 231 RCPCQNGGTCHHITGE-------CACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC 283
Query: 408 ISSLSGFTCQCPEGYFGSACEEKVD------PCASS-PCQNNGTCYVDGVHFTCNCSPGF 460
++G C C GY G C+E+ C+ C N G C C C PG+
Sbjct: 284 -DHVTG-QCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQC--SPTTGACECEPGY 339
Query: 461 TGPTCAQLI-------DFCALS-PC-AHGTCRSVGTSYKCLCDPGYHGLYCEEE-----Y 506
GP C + + C L PC A T + C C PG+ G +C E Y
Sbjct: 340 KGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYY 399
Query: 507 NECLSAPCL--NAATCRDLVNGYECVCLAEYKGTHCEL------YKDPCANV-SCLNGAT 557
+ PC N A C + G C C + G C + Y C+++ SC NG T
Sbjct: 400 GDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGT 457
Query: 558 CDSDGLNGTCICAPGFTGEECDID-------INECDSNPCHHGGSCLDQPNGYNCHCPHG 610
C ++G+C C G+ G +C + +N +S C +G +C P +C C G
Sbjct: 458 CSP--VDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAAC--SPIDGSCSCTPG 513
Query: 611 WVGANCEI 618
W+G CE+
Sbjct: 514 WLGDTCEL 521
Score = 113 bits (282), Expect = 7e-25
Identities = 98/355 (27%), Positives = 136/355 (38%), Gaps = 109/355 (30%)
Query: 310 GESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQN-------NA 362
G + ++ C+ G C S SCTC+E + G C PC + N
Sbjct: 443 GPNCSSICSCNNGGTC----SPVDGSCTCKEGWQGLDCT-------LPCPSGTWGLNCNE 491
Query: 363 SCIDANEKQ----DGSNFTCVCLPGYTGELCQ------------------SKIDYCILDP 400
SC AN DGS C C PG+ G+ C+ S D C DP
Sbjct: 492 SCTCANGAACSPIDGS---CSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGC--DP 546
Query: 401 CRNGATCISSLSGFTCQ--CPEGYFGSACEEKVDPCASSPCQNNGTCYV-DGVHFTCNCS 457
C++ +G C CP G +G C S C+N G+C DG +C C+
Sbjct: 547 VTGHCCCLAGWTGIRCDSTCPPGRWGPNCS------VSCSCENGGSCSPEDG---SCECA 597
Query: 458 PGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECL--SAPCL 515
PGF GP C ++ C PG++G C + C+ S PC
Sbjct: 598 PGFRGPLCQRI------------------------CPPGFYGHGCAQPCPLCVHSSRPCH 633
Query: 516 NAATCRDLVNGYECVCLAEYKGTHCE------LYKDPCANV-SCLNGATCDSDGLNGTCI 568
+ ++G C CL + G C + CA + SC N TC ++G+C
Sbjct: 634 H-------ISGI-CECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSP--IDGSCQ 683
Query: 569 CAPGFTGEECDIDINECDSNP-------CHHGGSCLDQPNGYNCHCPHGWVGANC 616
C PG+ G++C P CH+G SC + CHC GW G C
Sbjct: 684 CFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGA--CHCTPGWTGLFC 736
Score = 112 bits (279), Expect = 2e-24
Identities = 93/311 (29%), Positives = 123/311 (39%), Gaps = 73/311 (23%)
Query: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY--------DACQRKPCQNNASCIDANE 369
+CS C T C C + G C+ + C+N SC
Sbjct: 537 DCSHADGC----DPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSC----S 588
Query: 370 KQDGSNFTCVCLPGYTGELCQ-------------SKIDYCILD--PCRNGA---TCISSL 411
+DGS C C PG+ G LCQ C+ PC + + C+
Sbjct: 589 PEDGS---CECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGF 645
Query: 412 SGFTCQ--CPEGYFGSACEEKVDPCASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQL 468
SG C C GYFG C + C NNGTC +DG +C C PG+ G C+Q
Sbjct: 646 SGALCNQVCAGGYFGQDCAQLCS------CANNGTCSPIDG---SCQCFPGWIGKDCSQA 696
Query: 469 IDFCALSP-CAHGTCRSVGTSYK-----CLCDPGYHGLYCEEEY------NEC-LSAPCL 515
P C H G S C C PG+ GL+C + +C C
Sbjct: 697 CPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQ 756
Query: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDP------CANV-SCLNGATCDSDGLNGTCI 568
N A+C D ++G +C C + G HCE P C + C+N +TCD + GTC
Sbjct: 757 NGASC-DHISG-KCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDH--VTGTCY 812
Query: 569 CAPGFTGEECD 579
C+PGF G CD
Sbjct: 813 CSPGFKGIRCD 823
Score = 102 bits (255), Expect = 1e-21
Identities = 83/263 (31%), Positives = 104/263 (39%), Gaps = 73/263 (27%)
Query: 380 CLPGY--TGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD----- 432
C PGY +G+ C I C + C +G C+S TC C G+ G C D
Sbjct: 88 CCPGYYESGDFC---IPLCT-EECVHGR-CVSP---DTCHCEPGWGGPDCSSGCDSDHWG 139
Query: 433 PCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT-------CRSV 485
P S+ CQ + + C C+ GF G C +L CA P HG CR
Sbjct: 140 PHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEEL---CA--PGTHGKGCQLPCQCRHG 194
Query: 486 GT----SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
+ + +CLC PGY G+YCEE +C G HCE
Sbjct: 195 ASCDPRAGECLCAPGYTGVYCEE-------------------------LCPPGSHGAHCE 229
Query: 542 LYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEEC-------DIDINECDSNPCHHGG 594
L C NG TC + G C C PG+TG C N PCHHGG
Sbjct: 230 L------RCPCQNGGTCHH--ITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGG 281
Query: 595 SCLDQPNGYNCHCPHGWVGANCE 617
C D G CHC G++G C+
Sbjct: 282 QC-DHVTG-QCHCTAGYMGDRCQ 302
Score = 79.3 bits (194), Expect = 1e-14
Identities = 65/209 (31%), Positives = 83/209 (39%), Gaps = 50/209 (23%)
Query: 310 GESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-----------YDACQRKPC 358
G+ A C+ G C S SC C ++G C + + AC C
Sbjct: 660 GQDCAQLCSCANNGTC----SPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACS---C 712
Query: 359 QNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP-------CRNGATCISSL 411
N ASC +DG+ C C PG+TG C + C+NGA+C +
Sbjct: 713 HNGASC----SAEDGA---CHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASC-DHI 764
Query: 412 SGFTCQCPEGYFGSACEEKVDP------CAS-SPCQNNGTCYVDGVHFTCNCSPGFTGPT 464
SG C C G+ G CE++ P C C NN TC D V TC CSPGF G
Sbjct: 765 SG-KCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTC--DHVTGTCYCSPGFKGIR 821
Query: 465 CAQ-------LIDFCALSPCAHGTCRSVG 486
C Q L + +SP SVG
Sbjct: 822 CDQAALMMEELNPYTKISPALGAERHSVG 850
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/200 (28%), Positives = 73/200 (36%), Gaps = 45/200 (22%)
Query: 336 CTCEEQYVGTFCEEY--------DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGE 387
C C + G C + D Q C NN +C DGS C C PG+ G+
Sbjct: 639 CECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPI----DGS---CQCFPGWIGK 691
Query: 388 LCQSKIDYCILDP-------CRNGATCISSLSGFTCQCPEGYFGSACEEKV-------DP 433
C P C NGA+C S C C G+ G C ++ D
Sbjct: 692 DCSQACPPGFWGPACFHACSCHNGASC--SAEDGACHCTPGWTGLFCTQRCPAAFFGKDC 749
Query: 434 CASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT---CRSVGTSY- 489
CQN +C D + C C GFTG C Q CA +G C + S
Sbjct: 750 GRVCQCQNGASC--DHISGKCTCRTGFTGQHCEQR---CAPGTFGYGCQQLCECMNNSTC 804
Query: 490 -----KCLCDPGYHGLYCEE 504
C C PG+ G+ C++
Sbjct: 805 DHVTGTCYCSPGFKGIRCDQ 824
Score = 69.3 bits (168), Expect = 1e-11
Identities = 54/193 (27%), Positives = 73/193 (37%), Gaps = 52/193 (26%)
Query: 456 CSPGF--TGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAP 513
C PG+ +G C L C HG C S T C C+PG+ G C + P
Sbjct: 88 CCPGYYESGDFCIPL----CTEECVHGRCVSPDT---CHCEPGWGGPDCSSGCDSDHWGP 140
Query: 514 -------CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCAN-------VSCLNGATCD 559
C N A C + CVC A ++G CE P + C +GA+CD
Sbjct: 141 HCSNRCQCQNGALCNPITGA--CVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCD 198
Query: 560 SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIH 619
G C+CAPG+TG C+ CP G GA+CE+
Sbjct: 199 PRA--GECLCAPGYTGVYCEE-------------------------LCPPGSHGAHCELR 231
Query: 620 LQWKSGHMAESLT 632
++G +T
Sbjct: 232 CPCQNGGTCHHIT 244
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/88 (32%), Positives = 35/88 (39%), Gaps = 16/88 (18%)
Query: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCT--CPAGISGANCQLVADPCASNPCHHGNCS 109
PC+NGG C + P G G C CP G G NC + C PCHHG
Sbjct: 233 PCQNGGTCH---HITGECACPPGWTGAVCAQPCPPGTFGQNC---SQDC---PCHHGGQC 283
Query: 110 SSSSSSSDGYLCICNEGYEGPNCEQALP 137
+ C C GY G C++ P
Sbjct: 284 DHVTGQ-----CHCTAGYMGDRCQEECP 306
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/113 (30%), Positives = 46/113 (40%), Gaps = 19/113 (16%)
Query: 27 GPRGSSLANPVPAAPLSAPGPCAAQ-PCRNGGVCTSRPEPDPQHPAPAGEPGYSCT--CP 83
G G+ A P P P + C+ PC +GG C Q AG G C CP
Sbjct: 252 GWTGAVCAQPCP--PGTFGQNCSQDCPCHHGGQCD---HVTGQCHCTAGYMGDRCQEECP 306
Query: 84 AGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
G G C D CH+G S ++ + C C GY+GP C++ L
Sbjct: 307 FGSFGFQCSQHCD------CHNGGQCSPTTGA-----CECEPGYKGPRCQERL 348
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/91 (32%), Positives = 37/91 (40%), Gaps = 21/91 (23%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYS---CT---CPAGISGANCQLVADPCASNPCHHG 106
C NGG C+ P A EPGY C CP G+ G C L PC PC
Sbjct: 320 CHNGGQCS------PTTGACECEPGYKGPRCQERLCPEGLHGPGCTL---PC---PCDAD 367
Query: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
N S + C C G+ G +C ++ P
Sbjct: 368 NTISCHPVTG---ACTCQPGWSGHHCNESCP 395
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/99 (31%), Positives = 37/99 (37%), Gaps = 31/99 (31%)
Query: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLV----------ADPC---- 98
C NGG C+ PE SC C G G CQ + A PC
Sbjct: 581 CENGGSCS--PEDG------------SCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCV 626
Query: 99 -ASNPCHHGNCSSSSSSSSDGYLC--ICNEGYEGPNCEQ 134
+S PCHH + G LC +C GY G +C Q
Sbjct: 627 HSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQ 665
Score = 41.2 bits (95), Expect = 0.003
Identities = 36/112 (32%), Positives = 44/112 (39%), Gaps = 26/112 (23%)
Query: 42 LSAPG--------PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT-----CPAGISG 88
L APG PC CR+G C DP+ PGY+ CP G G
Sbjct: 175 LCAPGTHGKGCQLPCQ---CRHGASC------DPRAGECLCAPGYTGVYCEELCPPGSHG 225
Query: 89 ANCQLVADPCAS-NPCHHGNCSSSSSSSSDGYLCI--CNEGYEGPNCEQALP 137
A+C+L PC + CHH + G +C C G G NC Q P
Sbjct: 226 AHCELRC-PCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCP 276
Score = 40.0 bits (92), Expect = 0.008
Identities = 29/101 (28%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 39 AAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT--CPAGISGANCQLVAD 96
AA P + C NGG C+ D G G CT CP+G G NC +
Sbjct: 438 AAGTYGPNCSSICSCNNGGTCSP---VDGSCTCKEGWQGLDCTLPCPSGTWGLNCN---E 491
Query: 97 PCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
C C++ ++ S C C G+ G CE P
Sbjct: 492 SCT--------CANGAACSPIDGSCSCTPGWLGDTCELPCP 524
Score = 39.3 bits (90), Expect = 0.013
Identities = 30/106 (28%), Positives = 39/106 (36%), Gaps = 24/106 (22%)
Query: 57 GVCTSRPEPDPQH---PAPAGEPGYSCTCPAGI-SGANCQLVADPCASNPCHHG------ 106
G CT +P H P G G C P +GA+C + C P G
Sbjct: 377 GACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVS 436
Query: 107 --------NCSSSSSSSSDGYL------CICNEGYEGPNCEQALPS 138
NCSS S ++ G C C EG++G +C PS
Sbjct: 437 CAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPS 482
Score = 38.9 bits (89), Expect = 0.017
Identities = 31/100 (31%), Positives = 38/100 (38%), Gaps = 18/100 (18%)
Query: 39 AAPLSAPGPCA--AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT--CPAGISGANCQLV 94
A P GP A C NG C++ E H P G G CT CPA G +C V
Sbjct: 696 ACPPGFWGPACFHACSCHNGASCSA--EDGACHCTP-GWTGLFCTQRCPAAFFGKDCGRV 752
Query: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C + +S C C G+ G +CEQ
Sbjct: 753 CQ-----------CQNGASCDHISGKCTCRTGFTGQHCEQ 781
Score = 37.4 bits (85), Expect = 0.050
Identities = 28/110 (25%), Positives = 39/110 (35%), Gaps = 19/110 (17%)
Query: 44 APGPCAAQPCRNGGVCTSRPEPDP-----------QHPAPAGEPGYSCTCPAGISGANCQ 92
+P C +P G C+S + D Q+ A +C C AG G C+
Sbjct: 114 SPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCE 173
Query: 93 LVADPCASN-----PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137
+ P PC C +S C+C GY G CE+ P
Sbjct: 174 ELCAPGTHGKGCQLPC---QCRHGASCDPRAGECLCAPGYTGVYCEELCP 220
Score = 37.0 bits (84), Expect = 0.066
Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 13/67 (19%)
Query: 73 AGEPGYSC--TCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGP 130
AG G C TCP G G NC + +C + S S + C C G+ GP
Sbjct: 555 AGWTGIRCDSTCPPGRWGPNCSVSC-----------SCENGGSCSPEDGSCECAPGFRGP 603
Query: 131 NCEQALP 137
C++ P
Sbjct: 604 LCQRICP 610
Score = 37.0 bits (84), Expect = 0.066
Identities = 27/106 (25%), Positives = 39/106 (36%), Gaps = 19/106 (17%)
Query: 46 GPCAAQPCRNGGVCTSRPEP-----------DPQHPAPAGEPGYSCTCPAGISGANCQLV 94
G C P G CT R Q+ A CTC G +G +C+
Sbjct: 723 GACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCE-- 780
Query: 95 ADPCASNPCHHG-----NCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
CA +G C ++S+ C C+ G++G C+QA
Sbjct: 781 -QRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQA 825
Score = 36.6 bits (83), Expect = 0.086
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 2/62 (3%)
Query: 79 SCTCPAGISGANCQLVADPCASNP-CHHG-NCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
SC C G G +C P P C H +C + +S S++ C C G+ G C Q
Sbjct: 681 SCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRC 740
Query: 137 PS 138
P+
Sbjct: 741 PA 742
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 140 bits (352), Expect = 6e-33
Identities = 66/175 (37%), Positives = 89/175 (50%), Gaps = 22/175 (12%)
Query: 349 EYDACQRKPCQNNASC-------------------IDANEKQDGSNFTCVCLPGYTGELC 389
++D+C PCQN SC I ANE F C CLPGY G C
Sbjct: 3802 DHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQP--FLCKCLPGYAGSWC 3859
Query: 390 QSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDG 449
+ ID C+ PC +G TC + + GF+C CP+G+ G ACE ++ C SPC+N C
Sbjct: 3860 EIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFP 3919
Query: 450 VHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCE 503
F C C G+TG C +++C +PC + G+C+S SY C C G G +CE
Sbjct: 3920 GSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 133 bits (335), Expect = 5e-31
Identities = 66/192 (34%), Positives = 92/192 (47%), Gaps = 23/192 (11%)
Query: 432 DPCASSPCQNNGTCY----VDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGT 487
D C PCQN G+C V V + P + A P
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLP----------VIIVANEPLQ--------- 3844
Query: 488 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC 547
+ C C PGY G +CE + +ECL +PC + TC +LV G+ C C + G CE + C
Sbjct: 3845 PFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC 3904
Query: 548 ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHC 607
C NGA C + + C+C G+TG+ C+ +N C+ NPC +GGSC + Y CHC
Sbjct: 3905 LQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHC 3964
Query: 608 PHGWVGANCEIH 619
P G G +CE++
Sbjct: 3965 PFGVFGKHCELN 3976
Score = 115 bits (288), Expect = 1e-25
Identities = 62/189 (32%), Positives = 86/189 (45%), Gaps = 17/189 (8%)
Query: 394 DYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFT 453
D C+ PC+NG +C+ L+ S V A+ P Q F
Sbjct: 3804 DSCVHGPCQNGGSCLRRLA------VSSVLKSRESLPVIIVANEPLQP----------FL 3847
Query: 454 CNCSPGFTGPTCAQLIDFCALSPC-AHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSA 512
C C PG+ G C ID C SPC + GTC ++ + C C G+ G CE + NECL +
Sbjct: 3848 CKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQS 3907
Query: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
PC N A C++ + CVC Y G CE + C C NG +C S + C C G
Sbjct: 3908 PCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFG 3967
Query: 573 FTGEECDID 581
G+ C+++
Sbjct: 3968 VFGKHCELN 3976
Score = 103 bits (256), Expect = 7e-22
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 6/133 (4%)
Query: 334 FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
F C C Y G++CE + D C PC + +C + F+C C G+TG C+
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNL-----VGGFSCSCPDGFTGRACERD 3900
Query: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
I+ C+ PC+NGA C + F C C GY G CE V+ C +PC N G+C +
Sbjct: 3901 INECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSY 3960
Query: 453 TCNCSPGFTGPTC 465
C+C G G C
Sbjct: 3961 YCHCPFGVFGKHC 3973
Score = 95.5 bits (236), Expect = 2e-19
Identities = 44/128 (34%), Positives = 66/128 (51%), Gaps = 15/128 (11%)
Query: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQN 360
+ + C+P H+ G C FSC+C + + G CE + + C + PC+N
Sbjct: 3861 IDIDECLPSPCHSG-------GTCHNLVGG--FSCSCPDGFTGRACERDINECLQSPCKN 3911
Query: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
A C + +F CVC GYTG++C+S ++YC +PC NG +C S + + C CP
Sbjct: 3912 GAIC-----QNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPF 3966
Query: 421 GYFGSACE 428
G FG CE
Sbjct: 3967 GVFGKHCE 3974
Score = 55.8 bits (133), Expect = 1e-07
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 15/89 (16%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC +GG C + G+SC+CP G +G C+ + C +PC +G
Sbjct: 3866 CLPSPCHSGGTCHNLVG------------GFSCSCPDGFTGRACERDINECLQSPCKNGA 3913
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
+ S + C+C GY G CE ++
Sbjct: 3914 ICQNFPGS---FNCVCKTGYTGKMCESSV 3939
Score = 55.8 bits (133), Expect = 1e-07
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 15/86 (17%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C PC+NG +C + P ++C C G +G C+ + C NPC +G
Sbjct: 3904 CLQSPCKNGAICQNFPG------------SFNCVCKTGYTGKMCESSVNYCECNPCFNG- 3950
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
S S D Y C C G G +CE
Sbjct: 3951 --GSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 55.5 bits (132), Expect = 2e-07
Identities = 84/373 (22%), Positives = 130/373 (34%), Gaps = 70/373 (18%)
Query: 91 CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAP 150
C + C +PC HG S C C EG G CE+++ P T +
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQ---CHCKEGLTGKYCEKSVT--PDTALSLEGKG 4213
Query: 151 RQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSS 210
R + ++ + +L +S L + G +E+K+ S
Sbjct: 4214 RLDYHMSQNEKREYLLRQSLRGAMLEPF----GVNSLEVKF---------------RTRS 4254
Query: 211 AGGRLVSFEVPQN-TSVKIRQDA---TASLILLWKVTATGFQQCSLIDGRSVTPLQASGG 266
G L+ + N T+VKI+ T+ + KV + + DG T L G
Sbjct: 4255 ENGVLIHIQESSNYTTVKIKNGKVYFTSDAGIAGKVERN-IPEVYVADGHWHTFLIGKNG 4313
Query: 267 LVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCT 326
+ + + N I D + L + + P ++H D + +G C
Sbjct: 4314 TATVLSVDRIYNRDIIHPTQDFGGLDV------LTISLGGIPPNQAH-RDAQTAGFDGCI 4366
Query: 327 T-------------KPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDG 373
K S A+ S T +G C + C PC + CI+
Sbjct: 4367 ASMWYGGESLPFSGKHSLASISKTDPSVKIG--CRGPNICASNPCWGDLLCIN------- 4417
Query: 374 SNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL-SGFTCQCPEGYFGSACEEKVD 432
+ C+P G+ C PC+NG +C L SGFTC CP+ + G C E V
Sbjct: 4418 QWYAYRCVP--PGD--------CASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTC-EMVV 4466
Query: 433 PCASSPCQNNGTC 445
C C C
Sbjct: 4467 ACLGVLCPQGKVC 4479
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 14/84 (16%)
Query: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH 104
PG CA+ PC+NGG C P G++C+CP +G C++V C C
Sbjct: 4427 PGDCASHPCQNGGSCE-----------PGLHSGFTCSCPDSHTGRTCEMVV-ACLGVLCP 4474
Query: 105 HGNCSSSSSSSSDGYLCICNEGYE 128
G + S + G++C+ ++G E
Sbjct: 4475 QGKVCKAGSPA--GHVCVLSQGPE 4496
Score = 52.0 bits (123), Expect = 2e-06
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 48 CAAQPCRNGGVCTSRPEPDP----QHPAP----AGEP--GYSCTCPAGISGANCQLVADP 97
C PC+NGG C R + P A EP + C C G +G+ C++ D
Sbjct: 3806 CVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDE 3865
Query: 98 CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
C +PCH G + + G+ C C +G+ G CE+
Sbjct: 3866 CLPSPCHSG---GTCHNLVGGFSCSCPDGFTGRACER 3899
Score = 50.8 bits (120), Expect = 4e-06
Identities = 34/105 (32%), Positives = 46/105 (43%), Gaps = 5/105 (4%)
Query: 391 SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV 450
SK D + CR C S+ C ++ C D CAS PCQN G+C G+
Sbjct: 4388 SKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPPGD-CASHPCQNGGSCE-PGL 4445
Query: 451 H--FTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLC 493
H FTC+C TG TC +++ C C G G+ +C
Sbjct: 4446 HSGFTCSCPDSHTGRTC-EMVVACLGVLCPQGKVCKAGSPAGHVC 4489
Score = 48.5 bits (114), Expect = 2e-05
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 6/77 (7%)
Query: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP---N 601
DP + C C S+ G +C + C + +C S+PC +GGSC +P +
Sbjct: 4391 DPSVKIGCRGPNICASNPCWGDLLCINQWYAYRC-VPPGDCASHPCQNGGSC--EPGLHS 4447
Query: 602 GYNCHCPHGWVGANCEI 618
G+ C CP G CE+
Sbjct: 4448 GFTCSCPDSHTGRTCEM 4464
Score = 43.9 bits (102), Expect = 5e-04
Identities = 16/42 (38%), Positives = 22/42 (52%)
Query: 576 EECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
++C C +PC HGG+C+D + CHC G G CE
Sbjct: 4157 DQCPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/106 (28%), Positives = 40/106 (37%), Gaps = 15/106 (14%)
Query: 507 NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG- 565
N C S PC C + Y CV + CA+ C NG +C+ +G
Sbjct: 4402 NICASNPCWGDLLCINQWYAYRCVPPGD------------CASHPCQNGGSCEPGLHSGF 4449
Query: 566 TCICAPGFTGEECDIDINECDSNPCHHGGSC-LDQPNGYNCHCPHG 610
TC C TG C++ + C C G C P G+ C G
Sbjct: 4450 TCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAGSPAGHVCVLSQG 4494
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 19/96 (19%)
Query: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDG-SNF 376
C C P +F+C C+ Y G CE + C+ PC N SC Q G ++
Sbjct: 3909 CKNGAICQNFPG--SFNCVCKTGYTGKMCESSVNYCECNPCFNGGSC------QSGVDSY 3960
Query: 377 TCVCLPGYTGELCQ---------SKIDYCILDPCRN 403
C C G G+ C+ S +++ LDP N
Sbjct: 3961 YCHCPFGVFGKHCELNSYGFEELSYMEFPSLDPNNN 3996
Score = 37.4 bits (85), Expect = 0.050
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 465 CAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEE 504
C +L C SPC HG TC + +C C G G YCE+
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEK 4199
Score = 36.6 bits (83), Expect = 0.086
Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 12/46 (26%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL 93
C PC NGG C S G Y C CP G+ G +C+L
Sbjct: 3942 CECNPCFNGGSCQS------------GVDSYYCHCPFGVFGKHCEL 3975
Score = 36.6 bits (83), Expect = 0.086
Identities = 26/111 (23%), Positives = 41/111 (36%), Gaps = 28/111 (25%)
Query: 31 SSLANPVPAAPLSAPGP--CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISG 88
+S++ P+ + GP CA+ PC +C ++ Y C P
Sbjct: 4385 ASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWY------------AYRCVPPGD--- 4429
Query: 89 ANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSL 139
CAS+PC +G S G+ C C + + G CE + L
Sbjct: 4430 ---------CASHPCQNGG--SCEPGLHSGFTCSCPDSHTGRTCEMVVACL 4469
Score = 35.8 bits (81), Expect = 0.15
Identities = 15/43 (34%), Positives = 19/43 (44%)
Query: 427 CEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
C C SPCQ+ GTC C+C G TG C + +
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSV 4201
Score = 31.2 bits (69), Expect = 3.6
Identities = 12/40 (30%), Positives = 17/40 (42%)
Query: 502 CEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
C C +PC + TC D + +C C G +CE
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 135 bits (339), Expect = 2e-31
Identities = 93/347 (26%), Positives = 145/347 (41%), Gaps = 88/347 (25%)
Query: 353 CQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD-----PCRNGATC 407
C PCQN +C++ ++ +F C+C P + G LC + ++ C + C+NG TC
Sbjct: 136 CSSNPCQNGGTCLNLHD-----SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
Query: 408 ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQN--NGTC------YVDGVHFTCNCSPG 459
++++ ++C CP +G C K D C +G C ++C C G
Sbjct: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAG 250
Query: 460 F----TGPTCAQLIDFCALSPCAHGTCRSV-------GTSYKCLCDPGYHGL-YCEEEYN 507
+ P C D C+ P G C ++ G+ Y C G+ G Y E+ N
Sbjct: 251 WMFSPNSPACTLDRDECSFQP---GPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDIN 307
Query: 508 EC--------LSAP--CLN---AATCRDLVNGYE-------------------------- 528
EC ++ P C+N ++ C+ GY+
Sbjct: 308 ECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCS 367
Query: 529 --------CVCLAEYKG-----THCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFT 574
C CL Y G C + C + CLNG D+ ++G C C G+T
Sbjct: 368 STLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDT--VSGYFCKCDSGWT 425
Query: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQ 621
G C +INEC SNPC +GG+C+D + ++C C W GA C++ Q
Sbjct: 426 GVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQ 472
Score = 117 bits (294), Expect = 3e-26
Identities = 88/305 (28%), Positives = 122/305 (40%), Gaps = 67/305 (21%)
Query: 317 LECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRKPCQN--NASCIDANEKQDG 373
L C G C + ++SC C + G C +YD C+ + C D +Q G
Sbjct: 182 LSCQNGGTCVN--TMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAG 239
Query: 374 S-NFTCVCLPGY----TGELCQSKIDYCILDP--CRNGATCISSLSGFTC-QCPEGYFGS 425
++CVC G+ C D C P C C ++ F C CP G+ G+
Sbjct: 240 EPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN 299
Query: 426 A--------CE------------EKVDPCASSPCQ---------------------NNGT 444
CE E V+ SS CQ +NG
Sbjct: 300 GYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
Query: 445 CYVD-------GVHFTCNCSPGFTGPT-----CAQLIDFCALSPCAHGTCRSVGTSYKCL 492
C+ D G C C PG+TG C QL + C PC +G C + Y C
Sbjct: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCK 419
Query: 493 CDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCA-NVS 551
CD G+ G+ C E NECLS PCLN TC D V+ + C C + G C++ + C ++S
Sbjct: 420 CDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLS 479
Query: 552 CLNGA 556
+NG+
Sbjct: 480 GINGS 484
Score = 64.7 bits (156), Expect = 3e-10
Identities = 39/131 (29%), Positives = 59/131 (45%), Gaps = 17/131 (12%)
Query: 497 YHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC-----ANVS 551
+ GL + C S PC N TC +L + + C+C ++KG C + C +S
Sbjct: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
Query: 552 CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNP---CHHGGSCLD-------QPN 601
C NG TC + + +C C P G +C ++C+ C H G C D +P
Sbjct: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPK 242
Query: 602 GYNCHCPHGWV 612
Y+C C GW+
Sbjct: 243 -YSCVCDAGWM 252
Score = 64.3 bits (155), Expect = 4e-10
Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 534 EYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECD---SNP- 589
+++G + K C++ C NG TC + + CIC P + G C D+NEC+ P
Sbjct: 123 KFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPL 182
Query: 590 -CHHGGSCLDQPNGYNCHCPHGWVGANC 616
C +GG+C++ Y+CHCP G C
Sbjct: 183 SCQNGGTCVNTMGSYSCHCPPETYGPQC 210
Score = 47.4 bits (111), Expect = 5e-05
Identities = 37/124 (29%), Positives = 52/124 (41%), Gaps = 26/124 (20%)
Query: 30 GSSLANPVPAAPLSAPGPCAAQPCR-----NGGVCTSRP---------EPDPQHPAPAGE 75
G S+A PV ++ PG Q C +G VCT PD + G
Sbjct: 315 GCSVAPPVEC--VNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGS 372
Query: 76 PGYSCTCPAGISGAN-----CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGP 130
CTC G +G C +++ C S+PC +G C + S GY C C+ G+ G
Sbjct: 373 LPL-CTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVS----GYFCKCDSGWTGV 427
Query: 131 NCEQ 134
NC +
Sbjct: 428 NCTE 431
Score = 43.5 bits (101), Expect = 7e-04
Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 16/86 (18%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
C + PC NG + GY C C +G +G NC + C SNPC +G
Sbjct: 399 CLSHPCLNGQCIDT-------------VSGYFCKCDSGWTGVNCTENINECLSNPCLNG- 444
Query: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
+ D + C C + G C+
Sbjct: 445 --GTCVDGVDSFSCECTRLWTGALCQ 468
Score = 40.4 bits (93), Expect = 0.006
Identities = 29/116 (25%), Positives = 39/116 (33%), Gaps = 36/116 (31%)
Query: 48 CAAQPCRNGGVCTSRPEP-----DPQHPAP------------AGEP-------------- 76
C++ PC+NGG C + + PQ P +G P
Sbjct: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
Query: 77 GYSCTCPAGISGANCQLVADPCASNP---CHHGNCSS--SSSSSSDGYLCICNEGY 127
YSC CP G C D C C HG C + Y C+C+ G+
Sbjct: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGW 251
Score = 33.9 bits (76), Expect = 0.56
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 10/64 (15%)
Query: 73 AGEPGYSCTCPAG----ISGANCQLVADPCASNPCHHGNCSS---SSSSSSDGYLCICNE 125
AGEP YSC C AG + C L D C+ P G CS+ ++ Y C
Sbjct: 238 AGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQP---GPCSTLVQCFNTQGSFYCGACPT 294
Query: 126 GYEG 129
G++G
Sbjct: 295 GWQG 298
Score = 32.7 bits (73), Expect = 1.2
Identities = 16/54 (29%), Positives = 21/54 (38%), Gaps = 12/54 (22%)
Query: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
C + PC NGG C G +SC C +GA CQ+ C +
Sbjct: 436 CLSNPCLNGGTCVD------------GVDSFSCECTRLWTGALCQVPQQVCGES 477
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,994,158
Number of Sequences: 37866
Number of extensions: 2033863
Number of successful extensions: 19274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 215
Number of HSP's successfully gapped in prelim test: 412
Number of HSP's that attempted gapping in prelim test: 8170
Number of HSP's gapped (non-prelim): 4874
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.