Search of human proteins with 239741057

Search of human proteins with 239741057

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
sapiens]
         (408 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ...   811   0.0  
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ...   811   0.0  
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...   493   e-139
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          155   5e-38
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          122   8e-28
gi|194018474 leucine rich repeat containing 52 [Homo sapiens]         117   1e-26
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   105   7e-23
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                105   7e-23
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              95   1e-19
gi|4759146 slit homolog 2 [Homo sapiens]                               94   2e-19
gi|188528675 slit homolog 1 [Homo sapiens]                             94   3e-19
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    92   8e-19
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    92   1e-18
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    92   1e-18
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    91   2e-18
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          90   4e-18
gi|11321571 slit homolog 3 [Homo sapiens]                              87   3e-17
gi|198041768 synleurin [Homo sapiens]                                  87   3e-17
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       87   3e-17
gi|116268101 leucine rich repeat containing 62 [Homo sapiens]          86   8e-17
gi|40217825 slit and trk like 6 [Homo sapiens]                         84   2e-16
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    82   1e-15
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    82   1e-15
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    82   1e-15
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    82   1e-15
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 82   1e-15
gi|225579152 insulin-like growth factor binding protein, acid la...    81   2e-15
gi|4826772 insulin-like growth factor binding protein, acid labi...    81   2e-15
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...    80   3e-15
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...    80   3e-15

>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  811 bits (2094), Expect = 0.0
 Identities = 408/408 (100%), Positives = 408/408 (100%)

Query: 1   MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA 60
           MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA
Sbjct: 1   MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA 60

Query: 61  PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP 120
           PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP
Sbjct: 61  PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP 120

Query: 121 SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN 180
           SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN
Sbjct: 121 SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN 180

Query: 181 RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 240
           RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS
Sbjct: 181 RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 240

Query: 241 AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
           AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN
Sbjct: 241 AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300

Query: 301 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT 360
           PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT
Sbjct: 301 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT 360

Query: 361 DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD 408
           DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD
Sbjct: 361 DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD 408


>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  811 bits (2094), Expect = 0.0
 Identities = 408/408 (100%), Positives = 408/408 (100%)

Query: 1   MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA 60
           MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA
Sbjct: 1   MELLLQPVNGLVTKSQLCLWSREPVPSRQAAPSKRLESVSFPGAHEMSSRSLARPVSPSA 60

Query: 61  PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP 120
           PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP
Sbjct: 61  PRSIAPARPGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSP 120

Query: 121 SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN 180
           SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN
Sbjct: 121 SLRRRGARALQPSAAARARARVPRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGN 180

Query: 181 RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 240
           RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS
Sbjct: 181 RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 240

Query: 241 AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
           AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN
Sbjct: 241 AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300

Query: 301 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT 360
           PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT
Sbjct: 301 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLT 360

Query: 361 DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD 408
           DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD
Sbjct: 361 DLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD 408


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score =  493 bits (1270), Expect = e-139
 Identities = 250/250 (100%), Positives = 250/250 (100%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA
Sbjct: 5   RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 64

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
           KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL
Sbjct: 65  KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 124

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338
           RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR
Sbjct: 125 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 184

Query: 339 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 398
           RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD
Sbjct: 185 RISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKD 244

Query: 399 AEDEDEDKDD 408
           AEDEDEDKDD
Sbjct: 245 AEDEDEDKDD 254


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  155 bits (393), Expect = 5e-38
 Identities = 88/240 (36%), Positives = 124/240 (51%), Gaps = 1/240 (0%)

Query: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
           SVP   P+D R L +A NRI  +P  +   Y +L  LD  NNSL  L  G F  + +L  
Sbjct: 101 SVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAH 160

Query: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNN-LVGVHEDAFETLESLQVLELNDNNLRSL 281
           LDLSYNN + + A  F+ A  LV + L++N  L  VH  AF+ L  L+ L+L+   L  L
Sbjct: 161 LDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFL 220

Query: 282 SVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRIS 341
           S+ AL  LP L +L++ GNPW+C C    L  W++    +        +C  P E     
Sbjct: 221 SLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAP 280

Query: 342 LRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAED 401
           L  L+E SF  C  +L+L D   I F G  VSIA++ ++F L     C  R +   + E+
Sbjct: 281 LFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEE 340


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  122 bits (305), Expect = 8e-28
 Identities = 81/226 (35%), Positives = 108/226 (47%), Gaps = 3/226 (1%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           LP+VP    L +R LL+  NR++ +P   F   G L  LD R N L S+    F G   L
Sbjct: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             LDLS N L  L  G F     L  LSLA N L  +   A   L  L+ L L DN L +
Sbjct: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAA 181

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLPMESRR 339
           L+   L  LPAL +L L GNPW C C    L +W++ +   LP    + + C  P     
Sbjct: 182 LAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWPGRLTL 239

Query: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 385
             L   S+A+FS C   L+L DL ++   G A  + ++ S   L +
Sbjct: 240 SPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285


>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score =  117 bits (294), Expect = 1e-26
 Identities = 78/245 (31%), Positives = 113/245 (46%), Gaps = 2/245 (0%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L   P   PL+ R+L +  NRI  +P        DLVYLD +NN +R + + TF G  KL
Sbjct: 44  LTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKL 103

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGVHEDAFETLESLQVLELNDNNLR 279
           ++LDLS NNLT +    F     LV+L++ANN +L+ +H+  F    SL+ L+L +  L+
Sbjct: 104 IYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQ 163

Query: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339
           +L  AAL  L  L +L L GNPW C+C F   F+         P       C  P E   
Sbjct: 164 TLDSAALYHLTTLETLFLSGNPWKCNCSFLD-FAIFLIVFHMDPSDDLNATCVEPTELTG 222

Query: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDA 399
             +  +       C   L   D   ++  G  +  A  ++++         Q        
Sbjct: 223 WPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSE 282

Query: 400 EDEDE 404
           EDEDE
Sbjct: 283 EDEDE 287


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  105 bits (262), Expect = 7e-23
 Identities = 57/143 (39%), Positives = 79/143 (55%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N ++ +P   F     LV L   +N L ++ EGTF+  + L  L LSYN +T L AG FR
Sbjct: 275 NMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFR 334

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
               LVKL L +NNL  +H   F+ L  L++L L+ N L +L          L +L L G
Sbjct: 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHG 394

Query: 300 NPWLCDCDFAHLFSWIQENASKL 322
           NPW CDC  A+LF+W+Q+   +L
Sbjct: 395 NPWQCDCHLAYLFNWLQQYTDRL 417



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 68/211 (32%), Positives = 90/211 (42%), Gaps = 18/211 (8%)

Query: 160 GLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 219
           GLP + D        L V G+    +  + F     L  L    N L +L EG F   A 
Sbjct: 95  GLPRLED--------LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA 146

Query: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
           L  L L  N L  L    F+    L  L+LA N L  + E+ F  L SLQ L+L++N L 
Sbjct: 147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALS 206

Query: 280 SLSVAALAALPALRSLRLDGN--PWLCDCDFAHLFS----WIQENA-SKLPKGLDEIQCS 332
            L       L +L+ L LD N    L    F+ LF     W+Q NA + LP  +     +
Sbjct: 207 GLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGN 266

Query: 333 LPMESRRIS-LRELSEASFSE--CRFSLSLT 360
           L   S + + LR L    F+   C   LSLT
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLT 297



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 56/177 (31%), Positives = 77/177 (43%), Gaps = 7/177 (3%)

Query: 142 VPRGLRLHRPAHRGLPRRG--LPSVPDPF--PLDVRKLL-VAGNRIQRIPEDFFIFYGDL 196
           +P GL  H  A   L  +G  L ++P     PL   K L +A N + ++PE+ F     L
Sbjct: 136 LPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSL 195

Query: 197 VYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVG 256
             L   NN+L  L +G F     L  L L  NN+++L    F     L +L L  N +  
Sbjct: 196 QTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITH 255

Query: 257 VHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN--PWLCDCDFAHL 311
           +    F +L +L  L L  N LR L     A  P L  L L  N    + +  FAHL
Sbjct: 256 LPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  105 bits (262), Expect = 7e-23
 Identities = 66/173 (38%), Positives = 87/173 (50%), Gaps = 4/173 (2%)

Query: 181 RIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRS 240
           ++  +P + F     L YL  + NSL  L++  F+  A L  L L  N L  L    FR 
Sbjct: 142 QLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRG 201

Query: 241 AGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
            G L +L L  N L GVH  AF  L  L +L L +N+L SL   ALA LP+L  LRL+ N
Sbjct: 202 LGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261

Query: 301 PWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSEC 353
           PW CDC    L++W Q    +      ++ C+ P E +   LR L EA F  C
Sbjct: 262 PWACDCRARPLWAWFQ----RARVSSSDVTCATPPERQGRDLRALREADFQAC 310



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 39/106 (36%), Positives = 53/106 (50%), Gaps = 3/106 (2%)

Query: 199 LDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGV 257
           L  +NN +R+L  GTF   + L+ L L  NNL+ +  G FR    L +L L +N +L  +
Sbjct: 65  LFLQNNLIRTLRPGTF--GSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122

Query: 258 HEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWL 303
             D F+ LE LQ L L    L SL       L +L+ L L  N  L
Sbjct: 123 EPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLL 168


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 60/172 (34%), Positives = 83/172 (48%), Gaps = 4/172 (2%)

Query: 182 IQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSA 241
           +Q +    F     L YL  ++N+L++L + TF     L  L L  N ++ +   AFR  
Sbjct: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL 201

Query: 242 GRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNP 301
             L +L L  N +  VH  AF  L  L  L L  NNL +L   ALA L AL+ LRL+ NP
Sbjct: 202 HSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNP 261

Query: 302 WLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSEC 353
           W+CDC    L++W+Q    K      E+ CSLP       L+ L+      C
Sbjct: 262 WVCDCRARPLWAWLQ----KFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGC 309


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 67/214 (31%), Positives = 95/214 (44%), Gaps = 28/214 (13%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS----- 215
           L SVP   P +  +L + GN I RI +  F     L  L    N + ++E G F      
Sbjct: 46  LRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKEL 105

Query: 216 -------------------GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVG 256
                              G+AKL  LDLS N +  +   AFR A  +  L L  N +  
Sbjct: 106 ERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165

Query: 257 VHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQ 316
           + + AF  L  L+VL LN+NN+  LSVA+   +P LR+ RL  N   CDC  A L  W++
Sbjct: 166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLR 225

Query: 317 ENASKLPKGLDEIQCSLPMESRRISLRELSEASF 350
           +     P+     QC  P   R  ++ E+ +  F
Sbjct: 226 QR----PRVGLYTQCMGPSHLRGHNVAEVQKREF 255



 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 56/198 (28%), Positives = 93/198 (46%), Gaps = 7/198 (3%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           +GL  +P   P  + ++ +  N I+ IP   F  Y  L  +D  NN +  L    F G  
Sbjct: 289 KGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLR 348

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L L  N +T+L    F     L  L L  N +  +  DAF+ L +L +L L DN L
Sbjct: 349 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 408

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338
           ++++    + L A++++ L  NP++CDC   HL  W+ +     P      +C+ P   R
Sbjct: 409 QTIAKGTFSPLRAIQTMHLAQNPFICDC---HL-KWLADYLHTNPIETSGARCTSP---R 461

Query: 339 RISLRELSEASFSECRFS 356
           R++ + + +    + R S
Sbjct: 462 RLANKRIGQIKSKKFRCS 479



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 42/153 (27%), Positives = 80/153 (52%), Gaps = 4/153 (2%)

Query: 199 LDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVH 258
           ++F NN +  +EEG F G++ +  + L+ N L  +    F+    L  L L +N +  V 
Sbjct: 563 INFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVG 622

Query: 259 EDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQEN 318
            D+F  L S+++L L DN + +++  A   L +L +L L  NP+ C+C  A L  W+++ 
Sbjct: 623 NDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK- 681

Query: 319 ASKLPKGLDEIQCSLPMESRRISLRELSEASFS 351
             ++  G    +C  P   + I +++++   F+
Sbjct: 682 -KRIVTG--NPRCQKPYFLKEIPIQDVAIQDFT 711



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 44/158 (27%), Positives = 71/158 (44%), Gaps = 25/158 (15%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           +GL  +P   P DV +L + GN+   +P++    Y  L  +D  NN + +L   +FS   
Sbjct: 743 KGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN-YKHLTLIDLSNNRISTLSNQSFSNMT 801

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
           +L+ L LSYN L                          +    F+ L+SL++L L+ N++
Sbjct: 802 QLLTLILSYNRLRC------------------------IPPRTFDGLKSLRLLSLHGNDI 837

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQ 316
             +   A   L AL  L +  NP  CDC+   L  W++
Sbjct: 838 SVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVK 875



 Score = 36.2 bits (82), Expect = 0.055
 Identities = 22/81 (27%), Positives = 38/81 (46%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           V ++L+  NR++ +    F     L  L  R+N +  +   +F G + +  L L  N +T
Sbjct: 584 VNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQIT 643

Query: 232 QLGAGAFRSAGRLVKLSLANN 252
            +  GAF +   L  L+L  N
Sbjct: 644 TVAPGAFDTLHSLSTLNLLAN 664


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 66/216 (30%), Positives = 101/216 (46%), Gaps = 28/216 (12%)

Query: 160 GLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 219
           GL ++P   P +  +L + GN I RI ++ F     L  L    N + ++E G F    +
Sbjct: 51  GLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKE 110

Query: 220 L----------------VF--------LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLV 255
           L                +F        LDLS N +  +   AFR A  L  L L  N + 
Sbjct: 111 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 170

Query: 256 GVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWI 315
            + E AF  L  L+VL LN+NN+ ++ V++   +P LR+ RL  N   CDC  A L  W+
Sbjct: 171 CIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWL 230

Query: 316 QENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 351
           ++  +    GL   QCS P   R +++ E+ ++ FS
Sbjct: 231 RQRPT---IGL-FTQCSGPASLRGLNVAEVQKSEFS 262



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 56/191 (29%), Positives = 95/191 (49%), Gaps = 5/191 (2%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPED-FFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 219
           L  +P+  P    +L +  N I  +     F     L  ++  NN +  +E+G F G+A 
Sbjct: 531 LTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAAS 590

Query: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
           +  L L+ N L  + +G FR    L  L L NN +  +H D+F  L ++++L L DN + 
Sbjct: 591 VSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQIT 650

Query: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339
           ++S  A   L +L +L L  NP+ C+C  A L  W+++   K+  G    +C  P   R+
Sbjct: 651 TVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKR--KIVTG--NPRCQNPDFLRQ 706

Query: 340 ISLRELSEASF 350
           I L++++   F
Sbjct: 707 IPLQDVAFPDF 717



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 57/198 (28%), Positives = 96/198 (48%), Gaps = 7/198 (3%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           +GL ++P   P  + ++ +  N I+ IP   F  Y  L  +D  NN +  +    F G  
Sbjct: 298 KGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR 357

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L L  N +T L  G F     L  L L  N +  +  DAF+ L++L +L L DN +
Sbjct: 358 SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKI 417

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338
           +SL+     +L A+++L L  NP++CDC+   L  +++ N    P      +C+ P   R
Sbjct: 418 QSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTN----PIETSGARCASP---R 470

Query: 339 RISLRELSEASFSECRFS 356
           R++ + + +    + R S
Sbjct: 471 RLANKRIGQIKSKKFRCS 488



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 25/156 (16%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L ++P   P +V +L + GN+   +P                         G  S    L
Sbjct: 752 LRALPKGIPKNVTELYLDGNQFTLVP-------------------------GQLSTFKYL 786

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             +DLS N ++ L   +F +  +L  L L+ N L  +   AF+ L SL++L L+ N++ +
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQ 316
           L     A + +L  L +  NP  CDC    L SW++
Sbjct: 847 LQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK 882


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 3/197 (1%)

Query: 158 RRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGS 217
           ++GL  +P   P   R L +  N+I  +P   F     L+ L+  NNSL +L  G F G 
Sbjct: 38  QQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGL 97

Query: 218 AKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNN 277
             L  L+L+ N+L  L +  F S  +L +L L++NN+  +     ET E+L +L +  N 
Sbjct: 98  QHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQ 157

Query: 278 LRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL-DEIQCSLPME 336
           L+ L  A L ++P++R L L  N W C+C    L  W+++   K   GL D I C  P  
Sbjct: 158 LQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYK--GGLTDGIICESPDT 215

Query: 337 SRRISLRELSEASFSEC 353
            +   L  +    +  C
Sbjct: 216 WKGKDLLRIPHELYQPC 232


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 1/176 (0%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           R L SVP  FP +V  L ++ NR+  +PE  F     L  L   +N +R++  G  +  +
Sbjct: 39  RDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLS 98

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  LDLS+N ++        +   L  L + +N L  +  DAF +L +L+ L+LN N L
Sbjct: 99  HLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRL 158

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
            +L+      L AL  L+++ NP+ C C    L +W    A  +P+  D I C+ P
Sbjct: 159 HTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 1/176 (0%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           R L SVP  FP +V  L ++ NR+  +PE  F     L  L   +N +R++  G  +  +
Sbjct: 39  RDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLS 98

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  LDLS+N ++        +   L  L + +N L  +  DAF +L +L+ L+LN N L
Sbjct: 99  HLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRL 158

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
            +L+      L AL  L+++ NP+ C C    L +W    A  +P+  D I C+ P
Sbjct: 159 HTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 60/197 (30%), Positives = 86/197 (43%), Gaps = 7/197 (3%)

Query: 160 GLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 219
           GL +VP   P   R LL+  N++  +P   F     L  LD  NN L  L    F     
Sbjct: 58  GLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTN 117

Query: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
           L  L L  N++  L     R +  L  L L+ N L  +    F+ L +L+ L L  N L+
Sbjct: 118 LTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQ 177

Query: 280 SLSVAALAALPALRSLRLDGNPWLCDC---DFAHLFSWIQENASKLPKGLDEIQCSLPME 336
           +L       L  L+ L++  NPW CDC   +F H   W      +    LD++ C+LP E
Sbjct: 178 NLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGR----LDQLACTLPKE 233

Query: 337 SRRISLRELSEASFSEC 353
            R   +R +    F+ C
Sbjct: 234 LRGKDMRMVPMEMFNYC 250


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 61/179 (34%), Positives = 92/179 (51%), Gaps = 1/179 (0%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R+L +  N ++ +    F     L+ L   +N LR L  G F G A+L  L L+ N L 
Sbjct: 76  LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
           +L    F    RL +L L  N++  + + A   L SL +L+L+ N L ++S  AL  L +
Sbjct: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195

Query: 292 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLD-EIQCSLPMESRRISLRELSEAS 349
           L+ LRL  NPW CDC    L +WI+E   +L    D +I C+ P      SL ++S +S
Sbjct: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSS 254


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 56/198 (28%), Positives = 95/198 (47%), Gaps = 7/198 (3%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           +GL  +P   P  + ++ +  N I+ IP   F  Y  L  +D   N +  +    F G  
Sbjct: 296 KGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLK 355

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L L  N +T++  G F     L  L L  N +  +  + F+ L++L +L L DN L
Sbjct: 356 SLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 415

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338
           +++S    A L ++++L L  NP++CDC    L  ++Q+N    P      +CS P   R
Sbjct: 416 QTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN----PIETSGARCSSP---R 468

Query: 339 RISLRELSEASFSECRFS 356
           R++ + +S+    + R S
Sbjct: 469 RLANKRISQIKSKKFRCS 486



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 48/147 (32%), Positives = 74/147 (50%)

Query: 171 DVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNL 230
           ++R L +  N++  I    F     L  L    N L+ L E  F  + KL  LDLS N +
Sbjct: 86  NLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQI 145

Query: 231 TQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALP 290
             +   AFR    +  L L NN++  + + AF  L  L++L LN+NN+  + V +   +P
Sbjct: 146 QGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMP 205

Query: 291 ALRSLRLDGNPWLCDCDFAHLFSWIQE 317
            +R+LRL  N   CDC  A L  W+++
Sbjct: 206 KIRTLRLHSNHLYCDCHLAWLSDWLRQ 232



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 54/211 (25%), Positives = 96/211 (45%), Gaps = 12/211 (5%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPED-FFIFYGDLVYLDFRNNSLRSLEEGTFSGSAK 219
           L  +P   P  V  L +  N +  +     F    +L  ++  NN ++ + EG F G+A 
Sbjct: 523 LVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAAS 582

Query: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
           +  L L+ N L  +    FR    L  L L +N +  V  D F  L S+++L L DN + 
Sbjct: 583 VQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRIT 642

Query: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339
           +++  A   L +L ++ L  NP+ C+C  A L  W+++   ++  G    +C  P   + 
Sbjct: 643 TITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKR--RIVSG--NPRCQKPFFLKE 698

Query: 340 ISLRELSEASF-------SECRFSLSLTDLC 363
           I +++++   F       S C+ S    + C
Sbjct: 699 IPIQDVAIQDFTCDGNEESSCQLSPRCPEQC 729



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 54/180 (30%), Positives = 76/180 (42%), Gaps = 27/180 (15%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           +GL ++P   P DV +L + GN +  +P +       L  +D  NNS+  L   TFS  +
Sbjct: 741 KGLRALPRGMPKDVTELYLEGNHLTAVPRELSALR-HLTLIDLSNNSISMLTNYTFSNMS 799

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L LSYN L                        + VH  AF  L SL+VL L+ N++
Sbjct: 800 HLSTLILSYNRL----------------------RCIPVH--AFNGLRSLRVLTLHGNDI 835

Query: 279 RSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESR 338
            S+   +   L +L  L L  NP  CDC    L  W++  A     G+       PM  R
Sbjct: 836 SSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK--AGYKEPGIARCSSPEPMADR 893


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 6/176 (3%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R+L ++ N I+ I    F    +L YL  +N+ +R++    FSG   L  L LS+N+L 
Sbjct: 230 LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLE 289

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETL-ESLQVLELNDNNLRSLSVAALAALP 290
            L +  F     L+ L L  N ++ +  D FE +  SL++L L+ NNL +L    L  L 
Sbjct: 290 NLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLS 349

Query: 291 ALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELS 346
           +L  L+ + NPW C+C    L  W+  +A  L      I C  P   R  +LR ++
Sbjct: 350 SLIHLQANSNPWECNCKLLGLRDWLASSAITL-----NIYCQNPPSMRGRALRYIN 400



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 44/128 (34%), Positives = 65/128 (50%)

Query: 170 LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 229
           L++R L +  N++  +P   F     + YL+ + N L  L  GTF G   L  LDLS NN
Sbjct: 132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191

Query: 230 LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 289
           + ++    F+    L  L L +NNL  V  +AFE L+SL+ L L+ N + ++   A   L
Sbjct: 192 ILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGL 251

Query: 290 PALRSLRL 297
             L  L L
Sbjct: 252 ANLEYLLL 259



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 43/127 (33%), Positives = 63/127 (49%)

Query: 175 LLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLG 234
           L +  N I+R+    F    +L  L  + N +  +  G F+    + +L+L  N LT LG
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172

Query: 235 AGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRS 294
           +G F     L  L L+NNN++ + E  F+ LE+L  L L  NNL  +   A   L +LR 
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232

Query: 295 LRLDGNP 301
           L L  NP
Sbjct: 233 LSLSHNP 239


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 71/244 (29%), Positives = 96/244 (39%), Gaps = 37/244 (15%)

Query: 143 PRGLRLHRPAHRGLPRRGLPSVPDPFPLDVRK------------------------LLVA 178
           PR    + P       R L S+PD  P +V +                        L++ 
Sbjct: 30  PRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLH 89

Query: 179 GNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAF 238
            N I  IP+  F     L  L    N +R L++ TF G   L  L + +NN+  +    F
Sbjct: 90  SNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVF 149

Query: 239 RSAGRLVKLSLANNNLVGVHEDAFETLESLQV--------LELNDNNLRSLSVAALAALP 290
                L  + L  N L  +H D F +L  LQ+        L L+DN L SL    ++ +P
Sbjct: 150 YGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMP 209

Query: 291 ALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEI-----QCSLPMESRRISLREL 345
            L SL L GNPW CDC    L  WIQE    +    D       QC L M  R    + L
Sbjct: 210 DLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPL 269

Query: 346 SEAS 349
           +  S
Sbjct: 270 AMVS 273


>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
          Length = 820

 Score = 85.5 bits (210), Expect = 8e-17
 Identities = 52/174 (29%), Positives = 82/174 (47%), Gaps = 1/174 (0%)

Query: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
           ++P      V  L +  N+++ +       +G+L  L+   N +  +E+G F G + L  
Sbjct: 48  TIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQV 107

Query: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 282
           L L YN L+ L  G  R   RL  L + +N +  V   AF    SL  ++L+ N L  L 
Sbjct: 108 LQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLD 167

Query: 283 VAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPME 336
            A  A+L +L    L GNP+ C+CD     +W+    + + K  D +QC  P E
Sbjct: 168 GATFASLASLMVCELAGNPFNCECDLFGFLAWLVV-FNNVTKNYDRLQCESPRE 220


>gi|40217825 slit and trk like 6 [Homo sapiens]
          Length = 841

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 70/232 (30%), Positives = 100/232 (43%), Gaps = 38/232 (16%)

Query: 143 PRGLRLHRPAHRGLPRRGLPSVPD--PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLD 200
           P GL +H         R + S+ D  P P + RKL++AGN I  + +   + Y  L  L 
Sbjct: 340 PSGLLIH------CQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLH 393

Query: 201 FRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHED 260
             NN +  LEEG+F    +L  L L+ N+LT+L  G F     L  L L  N +  +   
Sbjct: 394 LGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPG 453

Query: 261 AFETLESLQVLELNDNNLRSLSVAALAALP------------------------ALRSLR 296
            F  +  L+VL LN+N L+ L     + +P                         L  + 
Sbjct: 454 TFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQID 513

Query: 297 LDGNPWLCDCDFAHLFSWIQENASKLPKG--LDEIQCSLPMESRRISLRELS 346
           L+ NPW C CD   L  WIQ    KL K    D+I C+ P    +  L+ L+
Sbjct: 514 LEDNPWDCSCDLVGLQQWIQ----KLSKNTVTDDILCTSPGHLDKKELKALN 561



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 45/138 (32%), Positives = 65/138 (47%), Gaps = 2/138 (1%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N I  I    F   G L  L   +NSL  L+E TF G   L FL    N +T +   AF 
Sbjct: 98  NNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFS 157

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS-VAALAALPALRSLRLD 298
              RL  L L +N +  +  + F  +  L  L+L  N L++L  V  L  +  +  L+L+
Sbjct: 158 KLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLE 216

Query: 299 GNPWLCDCDFAHLFSWIQ 316
            N W C+CD   L +W++
Sbjct: 217 DNKWACNCDLLQLKTWLE 234



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 18/58 (31%), Positives = 29/58 (50%)

Query: 243 RLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
           R  +LSL NN L  +H + F  L +   + L  NN+  + + A   L  L+ L ++ N
Sbjct: 65  RPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHN 122


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/174 (30%), Positives = 84/174 (48%), Gaps = 1/174 (0%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  +  ++L
Sbjct: 42  LREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQL 101

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N+N LR+
Sbjct: 102 KNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRT 161

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
           L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 162 LAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/174 (30%), Positives = 84/174 (48%), Gaps = 1/174 (0%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  +  ++L
Sbjct: 42  LREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQL 101

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N+N LR+
Sbjct: 102 KNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRT 161

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
           L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 162 LAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/174 (30%), Positives = 84/174 (48%), Gaps = 1/174 (0%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  +  ++L
Sbjct: 42  LREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQL 101

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N+N LR+
Sbjct: 102 KNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRT 161

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
           L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 162 LAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/174 (30%), Positives = 84/174 (48%), Gaps = 1/174 (0%)

Query: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220
           L  VP+  P +V  L ++ N+I  +    F     +  L   +N +R++E G  +  ++L
Sbjct: 42  LREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQL 101

Query: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280
             LDLS+N ++       R+   L  L + +N L  +  DA   L  L+ L +N+N LR+
Sbjct: 102 KNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRT 161

Query: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
           L+     AL AL  L+L  NP+ C C    L +W       LP+  D I C+ P
Sbjct: 162 LAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEP-DSIACASP 214


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 51/135 (37%), Positives = 64/135 (47%)

Query: 182 IQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSA 241
           +  +P   F     L YL  ++N +  L++  F     L  L L  N L  LG G FR  
Sbjct: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGL 196

Query: 242 GRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNP 301
             L +L L  N L  VH  AF  L  L  L L +N+L  L    LA L AL  LRL+GNP
Sbjct: 197 VNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNP 256

Query: 302 WLCDCDFAHLFSWIQ 316
           W C C    L+ W+Q
Sbjct: 257 WDCGCRARSLWEWLQ 271


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 36/218 (16%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +  L + G+ + RI    F     L  L  ++N L  +EE +  G A+L+ LDL+ N LT
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL-- 289
            L    F+  G+L  L L+ N L  +  DA   L+    L+++ N L +L  + LA L  
Sbjct: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGR 545

Query: 290 ------------------PALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL----- 326
                             P L  L L+GNPW C C    L  +  +N S +P+ +     
Sbjct: 546 LRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 605

Query: 327 -----------DEIQCSLPMESRRISLRELSEASFSEC 353
                      + I C+ P E   + LR+LSEA F+ C
Sbjct: 606 GDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 50/142 (35%), Positives = 63/142 (44%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           R L  +PD  P   + L + GN +  +P   F     L +L+ +   L SLE     G  
Sbjct: 101 RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 160

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L L  N L  L  G F     L  L L+NN L  + +  FE L SL  L L  N+L
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220

Query: 279 RSLSVAALAALPALRSLRLDGN 300
             L  AA   L +LR L L GN
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGN 242



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 43/121 (35%), Positives = 59/121 (48%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N+++ +    F     L  L   NN L  LE+G F G   L  L+L +N+L  L   AFR
Sbjct: 170 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 229

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
             G L +L LA N L  +    F  L  L+ L+L+ N LR++       LP L+ L LD 
Sbjct: 230 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 289

Query: 300 N 300
           N
Sbjct: 290 N 290



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 22/198 (11%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R+L++AGNR+  +    F    +L  LD   N+LR+++   F    +L  L L  N + 
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +  GAF     L  L L++N + G+ ED F  L  L+VL L+ N + SL       L  
Sbjct: 294 AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHF 353

Query: 292 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 351
           L  L+L  N              I++ A +  +GL +++  L ++  +  L+E+   +F 
Sbjct: 354 LEELQLGHNR-------------IRQLAERSFEGLGQLEV-LTLDHNQ--LQEVKAGAF- 396

Query: 352 ECRFSLSLTDLCIIIFSG 369
                L LT++ ++  SG
Sbjct: 397 -----LGLTNVAVMNLSG 409



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 47/157 (29%), Positives = 71/157 (45%), Gaps = 5/157 (3%)

Query: 144 RGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRN 203
           R L L R A R +       +P      ++KL +  N I  +    F+    L +LD  +
Sbjct: 259 RELDLSRNALRAIKANVFVQLPR-----LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 313

Query: 204 NSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFE 263
           N +  L E TF G   L  L LS+N +  L    F+    L +L L +N +  + E +FE
Sbjct: 314 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFE 373

Query: 264 TLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
            L  L+VL L+ N L+ +   A   L  +  + L GN
Sbjct: 374 GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 43/129 (33%), Positives = 64/129 (49%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R L ++ NR+  + ED F     L  L   +N++ SL   TF     L  L L +N + 
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
           QL   +F   G+L  L+L +N L  V   AF  L ++ V+ L+ N LR+L       L  
Sbjct: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425

Query: 292 LRSLRLDGN 300
           L SL L+G+
Sbjct: 426 LHSLHLEGS 434



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 44/121 (36%), Positives = 57/121 (47%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N +  +P+  F   G L  L    N L  L+   FSG A+L  LDLS N L  + A  F 
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
              RL KL L  N +  V   AF  L++L+ L+L+ N +  L       L  LR LRL  
Sbjct: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337

Query: 300 N 300
           N
Sbjct: 338 N 338



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 47/156 (30%), Positives = 70/156 (44%), Gaps = 2/156 (1%)

Query: 145 GLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNN 204
           GLR+ R +H  +      +  D   L+  +L +  NRI+++ E  F   G L  L   +N
Sbjct: 329 GLRVLRLSHNAIASLRPRTFKDLHFLE--ELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 386

Query: 205 SLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFET 264
            L+ ++ G F G   +  ++LS N L  L    FR  G+L  L L  + L  +    F  
Sbjct: 387 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 446

Query: 265 LESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
           L  L+ L L DN L  +   +L  L  L  L L  N
Sbjct: 447 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 40/124 (32%), Positives = 57/124 (45%)

Query: 177 VAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAG 236
           ++ NR+ R+ +  F   G L  L+   NSL  L +  F G   L  L L+ N L  L   
Sbjct: 191 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 250

Query: 237 AFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLR 296
            F     L +L L+ N L  +  + F  L  LQ L L+ N + +++  A   L ALR L 
Sbjct: 251 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 310

Query: 297 LDGN 300
           L  N
Sbjct: 311 LSHN 314



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 2/137 (1%)

Query: 166 DPFP--LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFL 223
           D FP  L +R L ++ N I  +    F     L  L   +N +R L E +F G  +L  L
Sbjct: 322 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 381

Query: 224 DLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSV 283
            L +N L ++ AGAF     +  ++L+ N L  + E  F  L  L  L L  + L  +  
Sbjct: 382 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 441

Query: 284 AALAALPALRSLRLDGN 300
                L  LR L L  N
Sbjct: 442 HTFTGLSGLRRLFLKDN 458


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 36/218 (16%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +  L + G+ + RI    F     L  L  ++N L  +EE +  G A+L+ LDL+ N LT
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL-- 289
            L    F+  G+L  L L+ N L  +  DA   L+    L+++ N L +L  + LA L  
Sbjct: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGR 507

Query: 290 ------------------PALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL----- 326
                             P L  L L+GNPW C C    L  +  +N S +P+ +     
Sbjct: 508 LRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 567

Query: 327 -----------DEIQCSLPMESRRISLRELSEASFSEC 353
                      + I C+ P E   + LR+LSEA F+ C
Sbjct: 568 GDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 50/142 (35%), Positives = 63/142 (44%)

Query: 159 RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSA 218
           R L  +PD  P   + L + GN +  +P   F     L +L+ +   L SLE     G  
Sbjct: 63  RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 122

Query: 219 KLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNL 278
            L  L L  N L  L  G F     L  L L+NN L  + +  FE L SL  L L  N+L
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182

Query: 279 RSLSVAALAALPALRSLRLDGN 300
             L  AA   L +LR L L GN
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGN 204



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 43/121 (35%), Positives = 59/121 (48%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N+++ +    F     L  L   NN L  LE+G F G   L  L+L +N+L  L   AFR
Sbjct: 132 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 191

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
             G L +L LA N L  +    F  L  L+ L+L+ N LR++       LP L+ L LD 
Sbjct: 192 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251

Query: 300 N 300
           N
Sbjct: 252 N 252



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 22/198 (11%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R+L++AGNR+  +    F    +L  LD   N+LR+++   F    +L  L L  N + 
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +  GAF     L  L L++N + G+ ED F  L  L+VL L+ N + SL       L  
Sbjct: 256 AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHF 315

Query: 292 LRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFS 351
           L  L+L  N              I++ A +  +GL +++  L ++  +  L+E+   +F 
Sbjct: 316 LEELQLGHNR-------------IRQLAERSFEGLGQLEV-LTLDHNQ--LQEVKAGAF- 358

Query: 352 ECRFSLSLTDLCIIIFSG 369
                L LT++ ++  SG
Sbjct: 359 -----LGLTNVAVMNLSG 371



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 47/157 (29%), Positives = 71/157 (45%), Gaps = 5/157 (3%)

Query: 144 RGLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRN 203
           R L L R A R +       +P      ++KL +  N I  +    F+    L +LD  +
Sbjct: 221 RELDLSRNALRAIKANVFVQLPR-----LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 275

Query: 204 NSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFE 263
           N +  L E TF G   L  L LS+N +  L    F+    L +L L +N +  + E +FE
Sbjct: 276 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFE 335

Query: 264 TLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
            L  L+VL L+ N L+ +   A   L  +  + L GN
Sbjct: 336 GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 43/129 (33%), Positives = 64/129 (49%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R L ++ NR+  + ED F     L  L   +N++ SL   TF     L  L L +N + 
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
           QL   +F   G+L  L+L +N L  V   AF  L ++ V+ L+ N LR+L       L  
Sbjct: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387

Query: 292 LRSLRLDGN 300
           L SL L+G+
Sbjct: 388 LHSLHLEGS 396



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 44/121 (36%), Positives = 57/121 (47%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           N +  +P+  F   G L  L    N L  L+   FSG A+L  LDLS N L  + A  F 
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
              RL KL L  N +  V   AF  L++L+ L+L+ N +  L       L  LR LRL  
Sbjct: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299

Query: 300 N 300
           N
Sbjct: 300 N 300



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 47/156 (30%), Positives = 70/156 (44%), Gaps = 2/156 (1%)

Query: 145 GLRLHRPAHRGLPRRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNN 204
           GLR+ R +H  +      +  D   L+  +L +  NRI+++ E  F   G L  L   +N
Sbjct: 291 GLRVLRLSHNAIASLRPRTFKDLHFLE--ELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 348

Query: 205 SLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFET 264
            L+ ++ G F G   +  ++LS N L  L    FR  G+L  L L  + L  +    F  
Sbjct: 349 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 408

Query: 265 LESLQVLELNDNNLRSLSVAALAALPALRSLRLDGN 300
           L  L+ L L DN L  +   +L  L  L  L L  N
Sbjct: 409 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 40/124 (32%), Positives = 57/124 (45%)

Query: 177 VAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAG 236
           ++ NR+ R+ +  F   G L  L+   NSL  L +  F G   L  L L+ N L  L   
Sbjct: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212

Query: 237 AFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLR 296
            F     L +L L+ N L  +  + F  L  LQ L L+ N + +++  A   L ALR L 
Sbjct: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272

Query: 297 LDGN 300
           L  N
Sbjct: 273 LSHN 276



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 2/137 (1%)

Query: 166 DPFP--LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFL 223
           D FP  L +R L ++ N I  +    F     L  L   +N +R L E +F G  +L  L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343

Query: 224 DLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSV 283
            L +N L ++ AGAF     +  ++L+ N L  + E  F  L  L  L L  + L  +  
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403

Query: 284 AALAALPALRSLRLDGN 300
                L  LR L L  N
Sbjct: 404 HTFTGLSGLRRLFLKDN 420


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 56/177 (31%), Positives = 80/177 (45%), Gaps = 4/177 (2%)

Query: 167 PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLS 226
           P P ++R+L +  N I  +P++ F     L  L    N +  +  G F+G  +L  L L 
Sbjct: 297 PMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 355

Query: 227 YNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAAL 286
            N L  L    FR    L  +SL NN L  +  + F  +  L  ++L +N L +L +   
Sbjct: 356 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF 415

Query: 287 AALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQ-CSLPMESRRISL 342
             L  L  LRL  NPW CD D   L +W+  N  +L  G D +  C  P   R  SL
Sbjct: 416 DHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRL--GTDTVPVCFSPANVRGQSL 470



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 39/138 (28%), Positives = 59/138 (42%)

Query: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
           +VP P P +   L +    I  + E  F+    L+ L    N L  +  G F     L +
Sbjct: 52  AVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRY 111

Query: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 282
           L L+ N L  L  G F+    L  L L++N L+ +    F    +L+ L+L+ N+L  + 
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171

Query: 283 VAALAALPALRSLRLDGN 300
             A   L  L  L L  N
Sbjct: 172 DGAFDHLVGLTKLNLGKN 189



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 44/126 (34%), Positives = 56/126 (44%)

Query: 175 LLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLG 234
           L +  N + RI    F   G L YL   NN L+ L  G F G   L  L LS N L Q+ 
Sbjct: 88  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147

Query: 235 AGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRS 294
              F     L +L L  N+L  + + AF+ L  L  L L  N+L  +S      L  L+ 
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207

Query: 295 LRLDGN 300
           LRL  N
Sbjct: 208 LRLYEN 213



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 41/129 (31%), Positives = 61/129 (47%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R L +A N++Q +P   F     L  L   +N L  ++   FS  + L  L L  N+L 
Sbjct: 109 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 168

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +  GAF     L KL+L  N+L  +    F+ L +LQVL L +N L  + +     L  
Sbjct: 169 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 228

Query: 292 LRSLRLDGN 300
           L+ L L  N
Sbjct: 229 LQELALQQN 237



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 41/127 (32%), Positives = 56/127 (44%)

Query: 174 KLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQL 233
           KL +  N +  I    F   G+L  L    N L  +  GTF G   L  L L  N +  L
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 242

Query: 234 GAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALR 293
             G F +   L +L L+NN++  +    F  L  L  L L  N+L+ LS+     +P LR
Sbjct: 243 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 302

Query: 294 SLRLDGN 300
            L L  N
Sbjct: 303 ELWLYDN 309



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 38/130 (29%), Positives = 59/130 (45%)

Query: 171 DVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNL 230
           ++++L + GN ++ IP+  F     L  L+   NSL  +    F     L  L L  N L
Sbjct: 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215

Query: 231 TQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALP 290
           T +  G F     L +L+L  N +  +    F    +LQ L L++N++  L  +    LP
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 275

Query: 291 ALRSLRLDGN 300
            L  L L GN
Sbjct: 276 QLNRLTLFGN 285



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 37/129 (28%), Positives = 55/129 (42%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +  LL++ N++ +I    F    +L  L    N L  + +G F     L  L+L  N+LT
Sbjct: 133 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 192

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +    F+  G L  L L  N L  +    F+ L +LQ L L  N +  LS         
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 252

Query: 292 LRSLRLDGN 300
           L+ L L  N
Sbjct: 253 LQRLYLSNN 261



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 38/131 (29%), Positives = 61/131 (46%)

Query: 170 LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 229
           +++++L +  N+I  +    F    +L  L   NN +  L    F    +L  L L  N+
Sbjct: 227 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 286

Query: 230 LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 289
           L +L  G F     L +L L +N++  + ++ F  L  LQVL L+ N +  +S  A   L
Sbjct: 287 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 346

Query: 290 PALRSLRLDGN 300
             LR L L  N
Sbjct: 347 TELRELSLHTN 357



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 37/121 (30%), Positives = 57/121 (47%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           NR+  IP   F    +L  L  + N +  L  G F  +  L  L LS N+++QL    F 
Sbjct: 213 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFM 272

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
              +L +L+L  N+L  +    F  + +L+ L L DN++ SL     + L  L+ L L  
Sbjct: 273 QLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 332

Query: 300 N 300
           N
Sbjct: 333 N 333


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 56/177 (31%), Positives = 80/177 (45%), Gaps = 4/177 (2%)

Query: 167 PFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLS 226
           P P ++R+L +  N I  +P++ F     L  L    N +  +  G F+G  +L  L L 
Sbjct: 291 PMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 349

Query: 227 YNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAAL 286
            N L  L    FR    L  +SL NN L  +  + F  +  L  ++L +N L +L +   
Sbjct: 350 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF 409

Query: 287 AALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQ-CSLPMESRRISL 342
             L  L  LRL  NPW CD D   L +W+  N  +L  G D +  C  P   R  SL
Sbjct: 410 DHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRL--GTDTVPVCFSPANVRGQSL 464



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 39/138 (28%), Positives = 59/138 (42%)

Query: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
           +VP P P +   L +    I  + E  F+    L+ L    N L  +  G F     L +
Sbjct: 46  AVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRY 105

Query: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 282
           L L+ N L  L  G F+    L  L L++N L+ +    F    +L+ L+L+ N+L  + 
Sbjct: 106 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165

Query: 283 VAALAALPALRSLRLDGN 300
             A   L  L  L L  N
Sbjct: 166 DGAFDHLVGLTKLNLGKN 183



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 44/126 (34%), Positives = 56/126 (44%)

Query: 175 LLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLG 234
           L +  N + RI    F   G L YL   NN L+ L  G F G   L  L LS N L Q+ 
Sbjct: 82  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141

Query: 235 AGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRS 294
              F     L +L L  N+L  + + AF+ L  L  L L  N+L  +S      L  L+ 
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201

Query: 295 LRLDGN 300
           LRL  N
Sbjct: 202 LRLYEN 207



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 41/129 (31%), Positives = 61/129 (47%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +R L +A N++Q +P   F     L  L   +N L  ++   FS  + L  L L  N+L 
Sbjct: 103 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 162

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +  GAF     L KL+L  N+L  +    F+ L +LQVL L +N L  + +     L  
Sbjct: 163 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 222

Query: 292 LRSLRLDGN 300
           L+ L L  N
Sbjct: 223 LQELALQQN 231



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 41/127 (32%), Positives = 56/127 (44%)

Query: 174 KLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQL 233
           KL +  N +  I    F   G+L  L    N L  +  GTF G   L  L L  N +  L
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236

Query: 234 GAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALR 293
             G F +   L +L L+NN++  +    F  L  L  L L  N+L+ LS+     +P LR
Sbjct: 237 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 296

Query: 294 SLRLDGN 300
            L L  N
Sbjct: 297 ELWLYDN 303



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 38/130 (29%), Positives = 59/130 (45%)

Query: 171 DVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNL 230
           ++++L + GN ++ IP+  F     L  L+   NSL  +    F     L  L L  N L
Sbjct: 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209

Query: 231 TQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALP 290
           T +  G F     L +L+L  N +  +    F    +LQ L L++N++  L  +    LP
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 269

Query: 291 ALRSLRLDGN 300
            L  L L GN
Sbjct: 270 QLNRLTLFGN 279



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 37/129 (28%), Positives = 55/129 (42%)

Query: 172 VRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLT 231
           +  LL++ N++ +I    F    +L  L    N L  + +G F     L  L+L  N+LT
Sbjct: 127 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 186

Query: 232 QLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPA 291
            +    F+  G L  L L  N L  +    F+ L +LQ L L  N +  LS         
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 246

Query: 292 LRSLRLDGN 300
           L+ L L  N
Sbjct: 247 LQRLYLSNN 255



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 38/131 (29%), Positives = 61/131 (46%)

Query: 170 LDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNN 229
           +++++L +  N+I  +    F    +L  L   NN +  L    F    +L  L L  N+
Sbjct: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280

Query: 230 LTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAAL 289
           L +L  G F     L +L L +N++  + ++ F  L  LQVL L+ N +  +S  A   L
Sbjct: 281 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 340

Query: 290 PALRSLRLDGN 300
             LR L L  N
Sbjct: 341 TELRELSLHTN 351



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 37/121 (30%), Positives = 57/121 (47%)

Query: 180 NRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 239
           NR+  IP   F    +L  L  + N +  L  G F  +  L  L LS N+++QL    F 
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFM 266

Query: 240 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDG 299
              +L +L+L  N+L  +    F  + +L+ L L DN++ SL     + L  L+ L L  
Sbjct: 267 QLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 326

Query: 300 N 300
           N
Sbjct: 327 N 327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,722,133
Number of Sequences: 37866
Number of extensions: 1059908
Number of successful extensions: 12919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 358
Number of HSP's successfully gapped in prelim test: 1248
Number of HSP's that attempted gapping in prelim test: 7760
Number of HSP's gapped (non-prelim): 4535
length of query: 408
length of database: 18,247,518
effective HSP length: 105
effective length of query: 303
effective length of database: 14,271,588
effective search space: 4324291164
effective search space used: 4324291164
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.