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Search of human proteins with 23110944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
(246 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 496 e-141
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] 226 1e-59
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] 226 1e-59
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] 226 1e-59
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 134 6e-32
gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 132 2e-31
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 131 5e-31
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 131 5e-31
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 124 6e-29
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 119 3e-27
gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 117 9e-27
gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 115 5e-26
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] 111 5e-25
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 104 6e-23
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 104 6e-23
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 92 3e-19
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 85 5e-17
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] 64 1e-10
gi|239744781 PREDICTED: zinc finger protein ENSP00000344568-like... 35 0.078
gi|4506195 proteasome beta 2 subunit [Homo sapiens] 34 0.13
gi|4506193 proteasome beta 1 subunit [Homo sapiens] 31 0.86
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 31 0.86
gi|22748957 interleukin 34 [Homo sapiens] 30 1.9
gi|38788380 dehydrogenase E1 and transketolase domain containing... 29 3.3
gi|239743841 PREDICTED: hypothetical protein XP_002342966 [Homo ... 28 7.3
gi|156139122 CXXC finger 6 [Homo sapiens] 28 7.3
gi|119964726 insulin-like growth factor 2 receptor precursor [Ho... 28 9.5
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo... 28 9.5
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ... 28 9.5
gi|8393378 frizzled 3 [Homo sapiens] 28 9.5
>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
Length = 246
Score = 496 bits (1276), Expect = e-141
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL 60
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
Sbjct: 1 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL 60
Query: 61 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD 120
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
Sbjct: 61 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD 120
Query: 121 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE 180
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
Sbjct: 121 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE 180
Query: 181 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV 240
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
Sbjct: 181 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV 240
Query: 241 ALAERD 246
ALAERD
Sbjct: 241 ALAERD 246
>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 226 bits (576), Expect = 1e-59
Identities = 132/226 (58%), Positives = 149/226 (65%), Gaps = 43/226 (19%)
Query: 6 SAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSST 65
S GFDRH+ IFSP+ +LYQV+YAFKAINQGGLTSVAVR KDCAVIVT K VPDKLLDS
Sbjct: 90 STGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSR- 148
Query: 66 VTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVY 125
THLFK+T+N G V+TG+TADSRS+ QRA+Y+AAN KY
Sbjct: 149 -THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKY---------------------- 185
Query: 126 TQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKK 185
I EE GP+VYKCD AGYYCGFKATAAGVKQ ESTSFLE VKK
Sbjct: 186 ----------------NIFEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE--VKK 227
Query: 186 KFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILT 231
KF WTFE + ++ D K SE E+ VVTVE P+FRILT
Sbjct: 228 KFAWTFEHSGNRNYMPFYCAIN-DLKSSETEIRVVTVEIPEFRILT 272
>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 226 bits (576), Expect = 1e-59
Identities = 132/226 (58%), Positives = 149/226 (65%), Gaps = 43/226 (19%)
Query: 6 SAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSST 65
S GFDRH+ IFSP+ +LYQV+YAFKAINQGGLTSVAVR KDCAVIVT K VPDKLLDS
Sbjct: 90 STGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSR- 148
Query: 66 VTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVY 125
THLFK+T+N G V+TG+TADSRS+ QRA+Y+AAN KY
Sbjct: 149 -THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKY---------------------- 185
Query: 126 TQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKK 185
I EE GP+VYKCD AGYYCGFKATAAGVKQ ESTSFLE VKK
Sbjct: 186 ----------------NIFEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE--VKK 227
Query: 186 KFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILT 231
KF WTFE + ++ D K SE E+ VVTVE P+FRILT
Sbjct: 228 KFAWTFEHSGNRNYMPFYCAIN-DLKSSETEIRVVTVEIPEFRILT 272
>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 226 bits (576), Expect = 1e-59
Identities = 132/226 (58%), Positives = 149/226 (65%), Gaps = 43/226 (19%)
Query: 6 SAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSST 65
S GFDRH+ IFSP+ +LYQV+YAFKAINQGGLTSVAVR KDCAVIVT K VPDKLLDS
Sbjct: 90 STGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSR- 148
Query: 66 VTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVY 125
THLFK+T+N G V+TG+TADSRS+ QRA+Y+AAN KY
Sbjct: 149 -THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKY---------------------- 185
Query: 126 TQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKK 185
I EE GP+VYKCD AGYYCGFKATAAGVKQ ESTSFLE VKK
Sbjct: 186 ----------------NIFEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE--VKK 227
Query: 186 KFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILT 231
KF WTFE + ++ D K SE E+ VVTVE P+FRILT
Sbjct: 228 KFAWTFEHSGNRNYMPFYCAIN-DLKSSETEIRVVTVEIPEFRILT 272
>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
Length = 234
Score = 134 bits (338), Expect = 6e-32
Identities = 84/236 (35%), Positives = 123/236 (52%), Gaps = 6/236 (2%)
Query: 8 GFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVT 67
G+ +T FSP G+L Q+EYA A+ GG SV ++ + V+ T+KK L D +V
Sbjct: 5 GYSFSLTTFSPSGKLVQIEYALAAV-AGGAPSVGIKAANGVVLATEKKQKSILYDERSVH 63
Query: 68 HLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ 127
+ IT++IG V +GM D R V RAR A + Y IP L +R+A + Q YTQ
Sbjct: 64 KVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQ 123
Query: 128 NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKF 187
+ +RP G +++ G +E + P +++ DP+G Y +KATA G +FLEK+ +
Sbjct: 124 SGGVRPFGVSLLICGWNEGR-PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE-- 180
Query: 188 DWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALA 243
D E + TAI L IEVG+ FR LT E+ +L A+A
Sbjct: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGI--CNEAGFRRLTPTEVKDYLAAIA 234
>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
Length = 248
Score = 132 bits (333), Expect = 2e-31
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 4/234 (1%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+DR IT+FSP+G L+QVEYA +A+ +G T+V VRG+D V+ +KK KL D TV
Sbjct: 3 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGVRGRDIVVLGVEKKSVAKLQDERTVRK 61
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
+ + +N+ G+TAD+R + RAR E + + + V+ + + IA + Q YTQ+
Sbjct: 62 ICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQS 121
Query: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
RP G +++G D + P++Y+ DP+G Y +KA A G FLEK +
Sbjct: 122 NGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAI 181
Query: 189 WTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
T + T++ I L V+ K E+ V + +IL EI+ ++ +
Sbjct: 182 ETDDLTIKLVIKALLEVVQSGGKNIEL---AVMRRDQSLKILNPEEIEKYVAEI 232
>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 131 bits (330), Expect = 5e-31
Identities = 78/235 (33%), Positives = 125/235 (53%), Gaps = 6/235 (2%)
Query: 6 SAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSST 65
S +D TIFSPEGRLYQVEYA +AI G T + + D ++ +++ KLLD
Sbjct: 2 SRRYDSRTTIFSPEGRLYQVEYAMEAIGHAG-TCLGILANDGVLLAAERRNIHKLLDEVF 60
Query: 66 VTH-LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQV 124
+ ++K+ E++ C + G+T+D+ R A + +Y IP + L + DI Q
Sbjct: 61 FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA 120
Query: 125 YTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVK 184
YTQ RP G ++ IG D+ G Q+Y+ DP+G Y G+KAT G + S L K+
Sbjct: 121 YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML-KQDY 179
Query: 185 KKFDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID 236
K+ + T + + AI L+ + + ++E+ +T EN K R+L + E++
Sbjct: 180 KEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE 234
>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 131 bits (330), Expect = 5e-31
Identities = 78/235 (33%), Positives = 125/235 (53%), Gaps = 6/235 (2%)
Query: 6 SAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSST 65
S +D TIFSPEGRLYQVEYA +AI G T + + D ++ +++ KLLD
Sbjct: 2 SRRYDSRTTIFSPEGRLYQVEYAMEAIGHAG-TCLGILANDGVLLAAERRNIHKLLDEVF 60
Query: 66 VTH-LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQV 124
+ ++K+ E++ C + G+T+D+ R A + +Y IP + L + DI Q
Sbjct: 61 FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA 120
Query: 125 YTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVK 184
YTQ RP G ++ IG D+ G Q+Y+ DP+G Y G+KAT G + S L K+
Sbjct: 121 YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML-KQDY 179
Query: 185 KKFDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID 236
K+ + T + + AI L+ + + ++E+ +T EN K R+L + E++
Sbjct: 180 KEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE 234
>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
Length = 250
Score = 124 bits (312), Expect = 6e-29
Identities = 72/234 (30%), Positives = 126/234 (53%), Gaps = 4/234 (1%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+DR IT+FSP+G L+QVEYA +A+ +G T+V +RG + V+ +KK KL D TV
Sbjct: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
+ + +++ G+TAD+R + RAR E + K + V+ + + IA + Q YTQ+
Sbjct: 64 ICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 123
Query: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
RP G +++G D++ ++Y+ DP+G Y +KA A G FLEK +
Sbjct: 124 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI 183
Query: 189 WTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
+ + ++ AI L V+ K IE+ ++ N ++ + E++ ++ +
Sbjct: 184 ASDSEAIKLAIKALLEVVQSGGK--NIELAIIR-RNQPLKMFSAKEVELYVTEI 234
>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
Length = 256
Score = 119 bits (297), Expect = 3e-27
Identities = 72/240 (30%), Positives = 127/240 (52%), Gaps = 10/240 (4%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+DR IT+FSP+G L+QVEYA +A+ +G T+V +RG + V+ +KK KL D TV
Sbjct: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
Query: 69 LFKITENIGC------VMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADIS 122
+ + +++ + G+TAD+R + RAR E + K + V+ + + IA +
Sbjct: 64 ICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLK 123
Query: 123 QVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKK 182
Q YTQ+ RP G +++G D++ ++Y+ DP+G Y +KA A G FLEK
Sbjct: 124 QKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKN 183
Query: 183 VKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
+ + + ++ AI L V+ K IE+ ++ N ++ + E++ ++ +
Sbjct: 184 YTEDAIASDSEAIKLAIKALLEVVQSGGK--NIELAIIR-RNQPLKMFSAKEVELYVTEI 240
>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
Length = 255
Score = 117 bits (293), Expect = 9e-27
Identities = 62/179 (34%), Positives = 97/179 (54%), Gaps = 1/179 (0%)
Query: 8 GFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVT 67
G+D + FSP+GR++QVEYA KA+ T++ +R KD V +K V KL + +
Sbjct: 7 GYDLSASTFSPDGRVFQVEYAMKAVENSS-TAIGIRCKDGVVFGVEKLVLSKLYEEGSNK 65
Query: 68 HLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ 127
LF + ++G + G+ AD+RS AR EA+N++ +GY IP+ L R+A YT
Sbjct: 66 RLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTL 125
Query: 128 NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKK 186
+ +RP GC +L G Q+Y DP+G G+ A G + + + +EK K+
Sbjct: 126 YSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKE 184
>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
Length = 241
Score = 115 bits (287), Expect = 5e-26
Identities = 63/233 (27%), Positives = 127/233 (54%), Gaps = 10/233 (4%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+DR + FSPEGRL+QVEYA +AI G T++ ++ + + +K++ L++ S++
Sbjct: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGS-TAIGIQTSEGVCLAVEKRITSPLMEPSSIEK 66
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ- 127
+ +I +IGC M+G+ AD+++ + +AR E N + Y + V+ + + +++++ + +
Sbjct: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEE 126
Query: 128 ----NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKV 183
A RP G ++ G+D E+GPQ++ DP+G + A A G + S L++
Sbjct: 127 DADPGAMSRPFGVALLFGGVD-EKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
Query: 184 KKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEID 236
K T ++ +++++ L V+ + IE+ V F + T+ E++
Sbjct: 186 HKSM--TLKEAIKSSLIILKQVMEEKLNATNIELATVQ-PGQNFHMFTKEELE 235
>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
Length = 248
Score = 111 bits (278), Expect = 5e-25
Identities = 61/179 (34%), Positives = 96/179 (53%), Gaps = 8/179 (4%)
Query: 8 GFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVT 67
G+D + FSP+GR++QVEYA KA+ T++ +R KD V +K V KL + +
Sbjct: 7 GYDLSASTFSPDGRVFQVEYAMKAVENSS-TAIGIRCKDGVVFGVEKLVLSKLYEEGSNK 65
Query: 68 HLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ 127
LF + ++G + G+ AD+RS AR EA+N++ +GY IP+ L R+A YT
Sbjct: 66 RLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTL 125
Query: 128 NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKK 186
+ +RP GC + G Q+Y DP+G G+ A G + + + +EK K+
Sbjct: 126 YSAVRPFGCSV-------NDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKE 177
>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
Length = 263
Score = 104 bits (260), Expect = 6e-23
Identities = 62/239 (25%), Positives = 122/239 (51%), Gaps = 7/239 (2%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+D +T++SP+GR++Q+EYA +A+ QG T V ++ K AV+V K+ +L ++
Sbjct: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSEL--AAHQKK 62
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
+ + +IG + G+TAD+R R E + ++ + +PV L I +Q+ TQ
Sbjct: 63 ILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQR 122
Query: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
RP G +++ G D + GP +++ P+ Y +A + G + + ++LE+ + + +
Sbjct: 123 YGRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 181
Query: 189 WTFEQTVETAITCLSTVLSI--DFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAER 245
+ V+ + L L D + +G+V ++ +F I + ++ L L ER
Sbjct: 182 CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVG-KDLEFTIYDDDDVSPFLEGLEER 239
>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
Length = 269
Score = 104 bits (260), Expect = 6e-23
Identities = 62/239 (25%), Positives = 122/239 (51%), Gaps = 7/239 (2%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+D +T++SP+GR++Q+EYA +A+ QG T V ++ K AV+V K+ +L ++
Sbjct: 12 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSEL--AAHQKK 68
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
+ + +IG + G+TAD+R R E + ++ + +PV L I +Q+ TQ
Sbjct: 69 ILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQR 128
Query: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
RP G +++ G D + GP +++ P+ Y +A + G + + ++LE+ + + +
Sbjct: 129 YGRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 187
Query: 189 WTFEQTVETAITCLSTVLSI--DFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAER 245
+ V+ + L L D + +G+V ++ +F I + ++ L L ER
Sbjct: 188 CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVG-KDLEFTIYDDDDVSPFLEGLEER 245
>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
Length = 212
Score = 92.4 bits (228), Expect = 3e-19
Identities = 63/234 (26%), Positives = 109/234 (46%), Gaps = 42/234 (17%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+DR IT+FSP+G L+QVEYA +A+ +G T+V +RG
Sbjct: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRG------------------------ 39
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
+TAD+R + RAR E + K + V+ + + IA + Q YTQ+
Sbjct: 40 --------------LTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 85
Query: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
RP G +++G D++ ++Y+ DP+G Y +KA A G FLEK +
Sbjct: 86 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI 145
Query: 189 WTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
+ + ++ AI L V+ K IE+ ++ N ++ + E++ ++ +
Sbjct: 146 ASDSEAIKLAIKALLEVVQSGGK--NIELAIIR-RNQPLKMFSAKEVELYVTEI 196
>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
Length = 190
Score = 85.1 bits (209), Expect = 5e-17
Identities = 50/164 (30%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 76 IGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLG 135
+ C + G+T+D+ R A + +Y IP + L + DI Q YTQ RP G
Sbjct: 1 MACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFG 60
Query: 136 CCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTV 195
++ IG D+ G Q+Y+ DP+G Y G+KAT G + S L K+ K+ + T + +
Sbjct: 61 VSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML-KQDYKEGEMTLKSAL 119
Query: 196 ETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID 236
AI L+ + + ++E+ +T EN K R+L + E++
Sbjct: 120 ALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE 163
>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
Length = 130
Score = 63.9 bits (154), Expect = 1e-10
Identities = 34/110 (30%), Positives = 62/110 (56%), Gaps = 3/110 (2%)
Query: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
+D +T++SP+GR++Q+EYA +A+ QG T V ++ K AV+V K+ +L ++
Sbjct: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSEL--AAHQKK 62
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRI 118
+ + +IG + G+TAD+R R E + ++ + +PV L I
Sbjct: 63 ILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLI 112
>gi|239744781 PREDICTED: zinc finger protein ENSP00000344568-like
[Homo sapiens]
Length = 600
Score = 34.7 bits (78), Expect = 0.078
Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Query: 148 GPQVYKCDPAG--YYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAI 199
G + YKC+ G +YC T + TE T + ++ K F W+ E T+ I
Sbjct: 503 GEESYKCEECGKGFYCSSSLTKHMIVHTEETXYKCEECGKAFKWSSELTIHQRI 556
>gi|4506195 proteasome beta 2 subunit [Homo sapiens]
Length = 201
Score = 33.9 bits (76), Expect = 0.13
Identities = 29/124 (23%), Positives = 54/124 (43%), Gaps = 17/124 (13%)
Query: 40 VAVRGKDCAVIVTQKKVPDKLLD-SSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEA 98
+ ++G D ++ + + ++ +FK++E I + G D+ VQ A Y
Sbjct: 5 IGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDT---VQFAEYIQ 61
Query: 99 AN---WKYKYGYEIP----VDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQV 151
N +K + GYE+ + + +AD + T P ++L G DE +GP +
Sbjct: 62 KNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRT------PYHVNLLLAGYDEHEGPAL 115
Query: 152 YKCD 155
Y D
Sbjct: 116 YYMD 119
>gi|4506193 proteasome beta 1 subunit [Homo sapiens]
Length = 241
Score = 31.2 bits (69), Expect = 0.86
Identities = 45/212 (21%), Positives = 87/212 (41%), Gaps = 15/212 (7%)
Query: 36 GLTSVAVRGKDCAVIVTQKKVPDKL-LDSSTVTHLFKITEN--IGCVMTGMTADSRSQVQ 92
G T +A+ G+D A++ + ++ + + + +K+T+ IGC +G D + +
Sbjct: 37 GGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGC--SGFHGDCLTLTK 94
Query: 93 RARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVY 152
+K+ + + ++ I +Y++ P I+ G+DEE VY
Sbjct: 95 IIEARLKMYKHSNNKAMTTGAIAAMLSTI--LYSRR--FFPYYVYNIIGGLDEEGKGAVY 150
Query: 153 KCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSI--DF 210
DP G Y A G +++ L+ + + + Q VE L + + D
Sbjct: 151 SFDPVGSYQRDSFKAGG----SASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDV 206
Query: 211 KPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
S E V T + + I+T+ I V+L
Sbjct: 207 FISAAERDVYTGDALRICIVTKEGIREETVSL 238
>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
Length = 273
Score = 31.2 bits (69), Expect = 0.86
Identities = 29/127 (22%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 58 DKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKR 117
D ++ + + I I C G+ AD+ + + G E R
Sbjct: 62 DSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGRE-------PR 114
Query: 118 IADISQVYTQNA--EMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTES 175
+A ++++ Q +G +I+ G+D GPQ+Y P G Y TA G Q +
Sbjct: 115 VATVTRILRQTLFRYQGHVGASLIVGGVDLT-GPQLYGVHPHGSYSRLPFTALGSGQDAA 173
Query: 176 TSFLEKK 182
+ LE +
Sbjct: 174 LAVLEDR 180
>gi|22748957 interleukin 34 [Homo sapiens]
Length = 242
Score = 30.0 bits (66), Expect = 1.9
Identities = 17/82 (20%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
++ +T+N C +TG D R +Y + Y +P + + RIA+++++
Sbjct: 26 MWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVF-RIANVTRLQRAQ 84
Query: 129 AEMRPLGCCMILIGIDEEQGPQ 150
R L +L+ + + Q
Sbjct: 85 VSERELRYLWVLVSLSATESVQ 106
>gi|38788380 dehydrogenase E1 and transketolase domain containing 1
[Homo sapiens]
Length = 919
Score = 29.3 bits (64), Expect = 3.3
Identities = 12/42 (28%), Positives = 24/42 (57%)
Query: 76 IGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKR 117
+GC + + DS +V RA A ++ ++ ++ +D+LC R
Sbjct: 390 VGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYR 431
>gi|239743841 PREDICTED: hypothetical protein XP_002342966 [Homo
sapiens]
Length = 601
Score = 28.1 bits (61), Expect = 7.3
Identities = 15/54 (27%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 148 GPQVYKCDPAG--YYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAI 199
G + YKC+ G +Y T + TE + ++ K F W+ E T+ I
Sbjct: 504 GEESYKCEECGKGFYYSSSLTKHMIVHTEEKLYKCEECGKAFKWSSELTIHQTI 557
>gi|156139122 CXXC finger 6 [Homo sapiens]
Length = 2136
Score = 28.1 bits (61), Expect = 7.3
Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 6/97 (6%)
Query: 140 LIGIDEEQGPQVYKCDPAGYYCG-FKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETA 198
+ GI+ E+ Q K + G F A ++++++ +K+ K F QTV
Sbjct: 702 MTGIEVEKWTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPK--LFVQTVRNG 759
Query: 199 IT---CLSTVLSIDFKPSEIEVGVVTVENPKFRILTE 232
I CL ++ FK IE T+EN ++ L +
Sbjct: 760 IKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKD 796
>gi|119964726 insulin-like growth factor 2 receptor precursor [Homo
sapiens]
Length = 2491
Score = 27.7 bits (60), Expect = 9.5
Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 10/81 (12%)
Query: 148 GPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD---WTFEQTVETAITCLST 204
G +V GY CG TA+ V + T + + K+FD T+ + ++ C
Sbjct: 2069 GDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACA-- 2126
Query: 205 VLSIDFKPSEIEVGVVTVENP 225
KP E+++ T+ NP
Sbjct: 2127 -----VKPQEVQMVNGTITNP 2142
>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
sapiens]
Length = 209
Score = 27.7 bits (60), Expect = 9.5
Identities = 26/111 (23%), Positives = 48/111 (43%), Gaps = 11/111 (9%)
Query: 42 VRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANW 101
V G D V + V +++ D + H E I C ++G AD+++ A Y+
Sbjct: 23 VMGSDSRVSAGEAVV-NRVFDKLSPLH-----ERIYCALSGSAADAQAVADMAAYQLE-- 74
Query: 102 KYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVY 152
+G E+ L A++ + + L +++ G D+ +G QVY
Sbjct: 75 --LHGIELEEPPLVLAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY 122
>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
sapiens]
Length = 219
Score = 27.7 bits (60), Expect = 9.5
Identities = 26/111 (23%), Positives = 48/111 (43%), Gaps = 11/111 (9%)
Query: 42 VRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANW 101
V G D V + V +++ D + H E I C ++G AD+++ A Y+
Sbjct: 33 VMGSDSRVSAGEAVV-NRVFDKLSPLH-----ERIYCALSGSAADAQAVADMAAYQLE-- 84
Query: 102 KYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVY 152
+G E+ L A++ + + L +++ G D+ +G QVY
Sbjct: 85 --LHGIELEEPPLVLAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY 132
>gi|8393378 frizzled 3 [Homo sapiens]
Length = 666
Score = 27.7 bits (60), Expect = 9.5
Identities = 21/79 (26%), Positives = 31/79 (39%), Gaps = 8/79 (10%)
Query: 83 MTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIG 142
+T R QRA E + +G P DM C R D + Y + ++ L G
Sbjct: 95 VTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLN-------LAG 147
Query: 143 IDEEQGPQVYKCDPAGYYC 161
E P + D G++C
Sbjct: 148 EPTEGAPVAVQRD-YGFWC 165
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,390,176
Number of Sequences: 37866
Number of extensions: 327542
Number of successful extensions: 674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 622
Number of HSP's gapped (non-prelim): 34
length of query: 246
length of database: 18,247,518
effective HSP length: 100
effective length of query: 146
effective length of database: 14,460,918
effective search space: 2111294028
effective search space used: 2111294028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.