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Search of human proteins with 228008333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|228008333 rhophilin, Rho GTPase binding protein 2 [Homo
sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|228008333 rhophilin, Rho GTPase binding protein 2 [Homo sapiens] 1355 0.0
gi|119120915 rhophilin 1 [Homo sapiens] 484 e-137
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [... 125 1e-28
gi|22027538 programmed cell death 6 interacting protein isoform ... 91 3e-18
gi|241982780 programmed cell death 6 interacting protein isoform... 89 2e-17
gi|124244088 Bro1-domain-containing protein [Homo sapiens] 40 0.007
gi|31742501 sorting nexin family member 27 [Homo sapiens] 38 0.027
gi|193083191 synaptopodin 2 isoform c [Homo sapiens] 37 0.061
gi|193083185 synaptopodin 2 isoform b [Homo sapiens] 37 0.061
gi|193083183 synaptopodin 2 isoform a [Homo sapiens] 37 0.061
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 37 0.079
gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 35 0.18
gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 35 0.18
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 35 0.23
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 35 0.30
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 34 0.39
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 34 0.39
gi|7706025 PDZ domain containing 11 [Homo sapiens] 34 0.39
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens] 33 1.1
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 32 1.5
gi|189571664 DEP domain containing 6 [Homo sapiens] 32 2.0
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens] 32 2.0
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens] 32 2.0
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens] 32 2.0
gi|8922944 lin-7 homolog C [Homo sapiens] 32 2.6
gi|40254851 protein kinase PKNbeta [Homo sapiens] 32 2.6
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 31 3.3
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 31 3.3
gi|169204710 PREDICTED: hypothetical protein [Homo sapiens] 31 3.3
gi|169205273 PREDICTED: hypothetical protein [Homo sapiens] 31 3.3
>gi|228008333 rhophilin, Rho GTPase binding protein 2 [Homo sapiens]
Length = 686
Score = 1355 bits (3507), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL 60
MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL
Sbjct: 1 MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL 60
Query: 61 LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET 120
LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET
Sbjct: 61 LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET 120
Query: 121 KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF 180
KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF
Sbjct: 121 KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF 180
Query: 181 VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA 240
VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA
Sbjct: 181 VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA 240
Query: 241 GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGI 300
GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGI
Sbjct: 241 GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGI 300
Query: 301 RNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFT 360
RNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFT
Sbjct: 301 RNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFT 360
Query: 361 AILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHH 420
AILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHH
Sbjct: 361 AILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHH 420
Query: 421 EESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV 480
EESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV
Sbjct: 421 EESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV 480
Query: 481 DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHF 540
DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHF
Sbjct: 481 DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHF 540
Query: 541 LDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSM 600
LDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSM
Sbjct: 541 LDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSM 600
Query: 601 HNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPS 660
HNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPS
Sbjct: 601 HNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPS 660
Query: 661 VGAARPQVKKKLPSPFSLLNSDSSWY 686
VGAARPQVKKKLPSPFSLLNSDSSWY
Sbjct: 661 VGAARPQVKKKLPSPFSLLNSDSSWY 686
>gi|119120915 rhophilin 1 [Homo sapiens]
Length = 670
Score = 484 bits (1247), Expect = e-137
Identities = 265/578 (45%), Positives = 370/578 (64%), Gaps = 6/578 (1%)
Query: 23 KGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNS 82
+GC+ L Q +LQ++RA ++QQI K ++MRTGAENL + +N++VRE V LELS+VNS
Sbjct: 20 QGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNS 79
Query: 83 DLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGY 142
+LQ+LKEELE L+ V ++ EA T+P+IPLGLKETK++D++ LK+ I H+ EDG
Sbjct: 80 NLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGA 139
Query: 143 LYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSL 202
YE EI +L LRQA RTPSR+E+G+ELL Y+ QL F+++RF P R +GL F WYDSL
Sbjct: 140 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSL 199
Query: 203 TGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDT 262
TGVP Q+ L EK SVLFN GAL+TQIG R DR G A++AFQRAAG + L++
Sbjct: 200 TGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLREN 259
Query: 263 FTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPG--IRNEFFMLVKVAQEAAKVGEV 320
F+H PS DMS A L L ++M+AQAQE VFE +S P + +++AQEAA+V
Sbjct: 260 FSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAE 319
Query: 321 YQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDL-DHQE 379
Y+ +H M+Q PV + +P SW +L VKA ++ +LAHY A+ L D +L H++
Sbjct: 320 YRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQ 379
Query: 380 KCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVL 439
L P G L ++RRQLGK+HL+RA+ EE++R +LC+ LR +++L
Sbjct: 380 VFLQPPTSSKPRGPVLPQEL---EERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLL 436
Query: 440 QKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKL 499
+ V+ +RS YA+ EDD +AP + KT Q+ + +P+ S+ D F +L
Sbjct: 437 RAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRL 496
Query: 500 GPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIV 559
GPLSVFSA RW + T EG G TLRG++PV + + P A+ AG +EGDYIV
Sbjct: 497 GPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIV 556
Query: 560 SIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDST 597
S+ C+W +EV+ LK+ GE ++VVSLL S+
Sbjct: 557 SVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSS 594
>gi|24308073 protein tyrosine phosphatase, non-receptor type 23
[Homo sapiens]
Length = 1636
Score = 125 bits (314), Expect = 1e-28
Identities = 82/252 (32%), Positives = 135/252 (53%), Gaps = 9/252 (3%)
Query: 110 IPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVE 169
+P+I L LKE D F +K F+L++Y E+ Y +E+ L LRQ RD G
Sbjct: 7 MPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCS 66
Query: 170 LLMTYFIQLGFVESRF-FPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYT 228
+L Y QL +++SR ++ + TW + +G V+ +++ E+A +L+N GAL++
Sbjct: 67 VLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHS 126
Query: 229 QIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQ 288
+G R ++ G++ + FQ AAG YL++ F S DMS +L++ V +ML QAQ
Sbjct: 127 MLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQ 186
Query: 289 ESVFEKISLPGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQ---APVKENIPYSWASLA 345
E + EK L R F VA+ +A+V + Y++ A+ A + I W L
Sbjct: 187 ECLLEKSMLDN-RKSFL----VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLV 241
Query: 346 CVKAHHYAALAH 357
+K +++AA+AH
Sbjct: 242 QMKIYYFAAVAH 253
>gi|22027538 programmed cell death 6 interacting protein isoform 1
[Homo sapiens]
Length = 868
Score = 91.3 bits (225), Expect = 3e-18
Identities = 110/410 (26%), Positives = 172/410 (41%), Gaps = 69/410 (16%)
Query: 113 IPLGLKETKDVDFAVVLKDFILEHY---SEDGYLYEDEIADLMDLRQAC--RTPSRDEAG 167
I + LK+T +VD A L FI + Y E+ Y +L LR+A R + E
Sbjct: 5 ISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGA 64
Query: 168 VELLMTYFIQLGFVESRFFPPTRQMGLLFTWYD-----SLTG--VPVSQQNLLLEKASVL 220
+E L+ Y+ Q+ +E +F Q+ L FTW D SL G V ++ +L EK+ VL
Sbjct: 65 LETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVL 124
Query: 221 FNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDT----FTHTPSYDMSPAML 276
FN AL +QI + GL+ A +Q A+G ++K+T + P+ D+SP +
Sbjct: 125 FNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTV 184
Query: 277 SVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKEN 336
L +MLAQAQE F K + +++ ++ K+A +AA A Q K+
Sbjct: 185 GTLSLIMLAQAQEVFFLKATRDKMKDA--IIAKLANQAA------DYFGDAFKQCQYKDT 236
Query: 337 IPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPL 396
+P + K A A Y +I L Q K G ++
Sbjct: 237 LPKEVFPVLAAKHCIMQANAEYHQSI-LAKQQKKFGEEI--------------------- 274
Query: 397 ATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQ 456
R Q ++ + ++E V K + + L AA++ + Y
Sbjct: 275 -------ARLQHAAELIKTVASRYDEYVNVKDFSDK------INRALAAAKKDNDFIY-- 319
Query: 457 HQEEDDLLNL--IDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSV 504
H DL +L I ++V T V I TD F+K+ P+SV
Sbjct: 320 HDRVPDLKDLDPIGKATLVKSTPVNVPI------SQKFTDLFEKMVPVSV 363
>gi|241982780 programmed cell death 6 interacting protein isoform 2
[Homo sapiens]
Length = 873
Score = 88.6 bits (218), Expect = 2e-17
Identities = 74/228 (32%), Positives = 117/228 (51%), Gaps = 19/228 (8%)
Query: 113 IPLGLKETKDVDFAVVLKDFILEHY---SEDGYLYEDEIADLMDLRQAC--RTPSRDEAG 167
I + LK+T +VD A L FI + Y E+ Y +L LR+A R + E
Sbjct: 5 ISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGA 64
Query: 168 VELLMTYFIQLGFVESRFFPPTRQMGLLFTWYD-----SLTG--VPVSQQNLLLEKASVL 220
+E L+ Y+ Q+ +E +F Q+ L FTW D SL G V ++ +L EK+ VL
Sbjct: 65 LETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVL 124
Query: 221 FNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDT----FTHTPSYDMSPAML 276
FN AL +QI + GL+ A +Q A+G ++K+T + P+ D+SP +
Sbjct: 125 FNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTV 184
Query: 277 SVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAK-VGEVYQQ 323
L +MLAQAQE F K + +++ ++ K+A +AA G+ ++Q
Sbjct: 185 GTLSLIMLAQAQEVFFLKATRDKMKDA--IIAKLANQAADYFGDAFKQ 230
>gi|124244088 Bro1-domain-containing protein [Homo sapiens]
Length = 411
Score = 40.0 bits (92), Expect = 0.007
Identities = 44/180 (24%), Positives = 76/180 (42%), Gaps = 29/180 (16%)
Query: 196 FTWYDSLTG-VPVSQQNLLLEKASVLFNTGALYTQIGTRC---DRQTQAGLESAIDAFQR 251
F W D+L G VP +QQ+ + E S+ FN YT+ +R + T+ + + +
Sbjct: 90 FKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKI 149
Query: 252 AAGVLNYLKDTFTHTPSY--------DMSPAMLSVLVKMMLAQAQE-SVFEKISL---PG 299
AAG+ +LK+ +H P D+ ++ V A+AQE ++ I L PG
Sbjct: 150 AAGIFKHLKE--SHLPKLITPAEKGRDLESRLIEAYVIQCQAEAQEVTIARAIELKHAPG 207
Query: 300 IRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYF 359
+ +A A + YQ+ +S ++ W +K Y A A+ +
Sbjct: 208 L---------IAALAYETANFYQKADHTLSS--LEPAYSAKWRKYLHLKMCFYTAYAYCY 256
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 38.1 bits (87), Expect = 0.027
Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 17/96 (17%)
Query: 514 PRSIRFTAEEGDLGFTLRGN---------------APVQ-VHFLDPYCSASVAGAREGDY 557
PR +R E GF +RG AP+Q V + P +A AG R+GD
Sbjct: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
Query: 558 IVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSL 593
I+ + V+ + T +V+ L+++ GE E+ + V+S+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRA-GEKELILTVLSV 135
>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
Length = 1109
Score = 37.0 bits (84), Expect = 0.061
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 527 GFTLRGNA----PVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G P+QV + AS +G EGD +VSI C LT EV+KL++S
Sbjct: 18 GFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESI- 76
Query: 583 EDEIEMKV 590
D ++M +
Sbjct: 77 TDSLQMLI 84
>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
Length = 1093
Score = 37.0 bits (84), Expect = 0.061
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 527 GFTLRGNA----PVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G P+QV + AS +G EGD +VSI C LT EV+KL++S
Sbjct: 18 GFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESI- 76
Query: 583 EDEIEMKV 590
D ++M +
Sbjct: 77 TDSLQMLI 84
>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
Length = 1261
Score = 37.0 bits (84), Expect = 0.061
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 527 GFTLRGNA----PVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G P+QV + AS +G EGD +VSI C LT EV+KL++S
Sbjct: 18 GFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESI- 76
Query: 583 EDEIEMKV 590
D ++M +
Sbjct: 77 TDSLQMLI 84
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 36.6 bits (83), Expect = 0.079
Identities = 20/68 (29%), Positives = 35/68 (51%)
Query: 515 RSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEV 574
R++R GFTLRG+ PV + + P A A + GD I+ + +D + + +V
Sbjct: 278 RTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKV 337
Query: 575 MKLLKSFG 582
+ +L+ G
Sbjct: 338 VSMLQGSG 345
>gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo
sapiens]
Length = 1376
Score = 35.4 bits (80), Expect = 0.18
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 512 TPPR--SIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWL 569
+PPR S+ GFTL G AP + + A G R GD I+++ ++ K
Sbjct: 16 SPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKA 75
Query: 570 TLSEVMKLL 578
+ +V+KL+
Sbjct: 76 SHEDVVKLI 84
>gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo
sapiens]
Length = 1447
Score = 35.4 bits (80), Expect = 0.18
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 512 TPPR--SIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWL 569
+PPR S+ GFTL G AP + + A G R GD I+++ ++ K
Sbjct: 16 SPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKA 75
Query: 570 TLSEVMKLL 578
+ +V+KL+
Sbjct: 76 SHEDVVKLI 84
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 25/179 (13%)
Query: 462 DLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTA 521
D + ++ ++ E+ +L + V + +L P+SV ++ + R++ T
Sbjct: 99 DYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIF---RTVEVTL 155
Query: 522 --EEGDLGFTLRGNA--------PVQVHFLDPYCSASVAGA-REGDYIVSIQLVDCKWLT 570
E GF +RG A PV + + P A G + GD ++S+ + T
Sbjct: 156 HKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTT 215
Query: 571 LSEVMKLLKSFGEDE---IEMKVVSLLDSTSSMHN-------KSATYSVGMQKTYSMIC 619
+E M +LK G++ IE VS++DS ++ K+ S+G+ T SM C
Sbjct: 216 HAEAMSILKQCGQEAALLIEYD-VSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCC 273
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
[Homo sapiens]
Length = 1235
Score = 34.7 bits (78), Expect = 0.30
Identities = 22/81 (27%), Positives = 39/81 (48%)
Query: 11 QPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVR 70
Q E++ F K N A+ ++KL+ + A Q +L+ ++M L ++ N K
Sbjct: 176 QKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKI 235
Query: 71 EQVRLELSFVNSDLQMLKEEL 91
+ +L VN DL + +E L
Sbjct: 236 HLLNTKLEHVNRDLSVKRESL 256
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 34.3 bits (77), Expect = 0.39
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 515 RSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEV 574
R + ++ GFT+ G+ V V + P +A AG +EGD I+ + + EV
Sbjct: 46 RCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEV 105
Query: 575 MKLLKS 580
+KL+KS
Sbjct: 106 VKLIKS 111
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 34.3 bits (77), Expect = 0.39
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 515 RSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEV 574
R + ++ GFT+ G+ V V + P +A AG +EGD I+ + + EV
Sbjct: 46 RCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEV 105
Query: 575 MKLLKS 580
+KL+KS
Sbjct: 106 VKLIKS 111
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 34.3 bits (77), Expect = 0.39
Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 514 PRSIRFTAEEG-DLGFTLRGNAPVQVHF----LDPYCSASVAGAREGDYIVSIQLVDCKW 568
PR+I G LGF +RG Q+ + P A AG +EGD ++++ VD +
Sbjct: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
Query: 569 LTLSEVMKLLKSFGEDEIEMKV 590
+ S+ +++LK+ EI M+V
Sbjct: 105 IEHSKAVEILKT--AREISMRV 124
>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
Length = 977
Score = 32.7 bits (73), Expect = 1.1
Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 5/73 (6%)
Query: 527 GFTLRGNA----PVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L G A P+QV + A AG RE D +++I V C L+ + M L+ + G
Sbjct: 18 GFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASG 77
Query: 583 EDEIEMKVVSLLD 595
+++ + V L D
Sbjct: 78 -NQLVLTVQRLAD 89
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 32.3 bits (72), Expect = 1.5
Identities = 21/83 (25%), Positives = 41/83 (49%)
Query: 383 SQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKV 442
SQ + +P+ L+ D +R Q SH+ R + ES+REA L + E+ +++
Sbjct: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950
Query: 443 LCAAQERSRLTYAQHQEEDDLLN 465
ER +L +++ ++L+
Sbjct: 1951 EHQKVERQQLLEDLREKQQEVLH 1973
>gi|189571664 DEP domain containing 6 [Homo sapiens]
Length = 409
Score = 32.0 bits (71), Expect = 2.0
Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 527 GFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEI 586
GF +RG+ P + +DP A+ AG + ++VS+ ++ + V L+ + G I
Sbjct: 341 GFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILT-GPRTI 399
Query: 587 EMKVVSLLD 595
M+V+ L+
Sbjct: 400 VMEVMEELE 408
>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
Length = 222
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 527 GFTLRG----NAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G N P+ + L P A+ AG GD+++SI + LT E +++ G
Sbjct: 15 GFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACG 74
Query: 583 E 583
E
Sbjct: 75 E 75
>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
Length = 423
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 527 GFTLRG----NAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G N P+ + L P A+ AG GD+++SI + LT E +++ G
Sbjct: 15 GFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACG 74
Query: 583 E 583
E
Sbjct: 75 E 75
>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
Length = 457
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 527 GFTLRG----NAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFG 582
GF L+G N P+ + L P A+ AG GD+++SI + LT E +++ G
Sbjct: 15 GFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACG 74
Query: 583 E 583
E
Sbjct: 75 E 75
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 31.6 bits (70), Expect = 2.6
Identities = 39/170 (22%), Positives = 71/170 (41%), Gaps = 14/170 (8%)
Query: 417 MAHHEESVR-EASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAK 475
MA E VR E +C+ + +E LQ+ +L Q + + N + V
Sbjct: 1 MAALGEPVRLERDICRAIELLEKLQR--SGEVPPQKLQALQRVLQSEFCNAVR--EVYEH 56
Query: 476 TEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRG--- 532
+ VDI + T ++ F+A++ + PR + E LGF + G
Sbjct: 57 VYETVDISSSPEVRANAT----AKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKE 112
Query: 533 -NAPVQVHFLDPYCSAS-VAGAREGDYIVSIQLVDCKWLTLSEVMKLLKS 580
N+P+ + + P A G + GD ++S+ V + + ++LLK+
Sbjct: 113 QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKA 162
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 31.6 bits (70), Expect = 2.6
Identities = 17/62 (27%), Positives = 34/62 (54%)
Query: 37 QNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNI 96
++++ + + I K ++++ G ENL +VAT+ + V+ L N L+ L EL L+
Sbjct: 17 EDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHA 76
Query: 97 SV 98
+
Sbjct: 77 RI 78
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 31.2 bits (69), Expect = 3.3
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 17/144 (11%)
Query: 514 PRSIRFTAEEGDLGFTLRGNAP---VQVHFLDPYCSASVAGA-REGDYIVSIQLVDCKWL 569
PR + LGF + G + + F+ A ++G R+GD I+S+ VD +
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 570 TLSEVMKLLKSFGE-------------DEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYS 616
+ + LK+ G+ E K+ L + + S + S+ + S
Sbjct: 524 SHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583
Query: 617 MICLAIDDDDKTDKTKKISKKLSF 640
+ A+ D DKT + S+ L+F
Sbjct: 584 LYVRALFDYDKTKDSGLPSQGLNF 607
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 31.2 bits (69), Expect = 3.3
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 17/144 (11%)
Query: 514 PRSIRFTAEEGDLGFTLRGNAP---VQVHFLDPYCSASVAGA-REGDYIVSIQLVDCKWL 569
PR + LGF + G + + F+ A ++G R+GD I+S+ VD +
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 570 TLSEVMKLLKSFGE-------------DEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYS 616
+ + LK+ G+ E K+ L + + S + S+ + S
Sbjct: 524 SHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583
Query: 617 MICLAIDDDDKTDKTKKISKKLSF 640
+ A+ D DKT + S+ L+F
Sbjct: 584 LYVRALFDYDKTKDSGLPSQGLNF 607
>gi|169204710 PREDICTED: hypothetical protein [Homo sapiens]
Length = 241
Score = 31.2 bits (69), Expect = 3.3
Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 5/65 (7%)
Query: 372 GTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCK 431
G D +HQ +C +L+ H +A L ++R++ K HL R H + A L K
Sbjct: 34 GEDAEHQLQCQEELHSHRLASRRAVAEL--GTEKRRMRKGHLCREGGAHRDC---AGLIK 88
Query: 432 KLRSI 436
+R++
Sbjct: 89 DIRTL 93
>gi|169205273 PREDICTED: hypothetical protein [Homo sapiens]
Length = 241
Score = 31.2 bits (69), Expect = 3.3
Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 5/65 (7%)
Query: 372 GTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCK 431
G D +HQ +C +L+ H +A L ++R++ K HL R H + A L K
Sbjct: 34 GEDAEHQLQCQEELHSHRLASRRAVAEL--GTEKRRMRKGHLCREGGAHRDC---AGLIK 88
Query: 432 KLRSI 436
+R++
Sbjct: 89 DIRTL 93
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,176,919
Number of Sequences: 37866
Number of extensions: 1009062
Number of successful extensions: 2677
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 2637
Number of HSP's gapped (non-prelim): 60
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.