Search of human proteins with 22749269

Search of human proteins with 22749269

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22749269 ring finger protein 129 [Homo sapiens]
         (471 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22749269 ring finger protein 129 [Homo sapiens]                    972   0.0  
gi|157743261 tripartite motif-containing 75 [Homo sapiens]            431   e-121
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   392   e-109
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]   376   e-104
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            277   2e-74
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             275   5e-74
gi|15208660 tripartite motif protein 21 [Homo sapiens]                270   3e-72
gi|5730009 ret finger protein [Homo sapiens]                          268   8e-72
gi|60099474 tripartite motif-containing 61 [Homo sapiens]             249   4e-66
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   245   7e-65
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    245   7e-65
gi|37622899 ring finger protein 137 [Homo sapiens]                    245   7e-65
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      239   5e-63
gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]      239   5e-63
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   239   5e-63
gi|5454014 tripartite motif-containing 38 [Homo sapiens]              230   2e-60
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    226   3e-59
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    226   3e-59
gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo s...   225   8e-59
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             223   2e-58
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   223   3e-58
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   217   2e-56
gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]   216   4e-56
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   213   4e-55
gi|117938316 tripartite motif-containing 22 [Homo sapiens]            211   1e-54
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    211   1e-54
gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo s...   209   4e-54
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]   207   1e-53
gi|4557743 Mediterranean fever protein [Homo sapiens]                 192   7e-49
gi|20270353 tripartite motif-containing 43 [Homo sapiens]             189   6e-48

>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  972 bits (2513), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60
           MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF
Sbjct: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60

Query: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120
           PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS
Sbjct: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120

Query: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180
           FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR
Sbjct: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180

Query: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240
           EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK
Sbjct: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240

Query: 241 SVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILD 300
           SVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILD
Sbjct: 241 SVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILD 300

Query: 301 LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP 360
           LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP
Sbjct: 301 LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP 360

Query: 361 KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD 420
           KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD
Sbjct: 361 KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD 420

Query: 421 YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICSVSDSER 471
           YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICSVSDSER
Sbjct: 421 YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICSVSDSER 471


>gi|157743261 tripartite motif-containing 75 [Homo sapiens]
          Length = 468

 Score =  431 bits (1107), Expect = e-121
 Identities = 217/465 (46%), Positives = 301/465 (64%), Gaps = 2/465 (0%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60
           M    AL  LQ E+ C ICL+YL DPVTI CGHNFCRSC+  SW DL + FPCPVCR   
Sbjct: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60

Query: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120
               FR N QL  + EIAK LQ  +S +++Q+E  +CEKHNQ L++FC +DL +LC  C+
Sbjct: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120

Query: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180
               HQ H++ PI+KAA ++R+     ++PL+  +  ++K+I  Q  K +EL++ VE +R
Sbjct: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180

Query: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240
           +E++SEFE +  FL  EQ+ +L ++ +EE +   KL+ N+   S+Y +TLK  L +V   
Sbjct: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240

Query: 241 SVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILD 300
           S  S LELL+Q K + ++ +N   P +FS  L + G S PPQYS L RIIK F+V++ILD
Sbjct: 241 SELSELELLSQIK-IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILD 299

Query: 301 LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP 360
             TAHP L+VSED+K VR+ ++K+ +   P+RF V P VLG   F SGRH+WE+EVG+K 
Sbjct: 300 PETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKS 359

Query: 361 KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD 420
           +W +G+C+D L    +   S     W I      GY A G   T LL  VK   IGIFLD
Sbjct: 360 EWAIGICKDSLPTKARRPSSAQQECWRI-ELQDDGYHAPGAFPTPLLLEVKARAIGIFLD 418

Query: 421 YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICS 465
           YE+G++SFYNM ++S + TF D FT  + PYFY G DS+PL+IC+
Sbjct: 419 YEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICT 463


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  392 bits (1006), Expect = e-109
 Identities = 204/473 (43%), Positives = 293/473 (61%), Gaps = 11/473 (2%)

Query: 6   ALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSF 65
           AL NLQ E+SC +CLEYLK+PV I CGHNFC++C++  W+DL+  FPCPVCR    Y+S 
Sbjct: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78

Query: 66  RRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKH 125
           R N QL ++ EIAKQLQ   + +++ ++ ++C +H++ L+LFC +D E +C  C+ S  H
Sbjct: 79  RPNRQLGSMVEIAKQLQ---AVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135

Query: 126 QKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINS 185
           + H + P+  A   ++E L+  LEPL   ++ + +    +  K  ELK+ VE +R++I  
Sbjct: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195

Query: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245
           EFE++   L  EQ+++L ++++EE +IL +L EN   L D    L HL  EVEGK +QS 
Sbjct: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255

Query: 246 LELLTQAKSMHHKYQNLKCPEL--FSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNT 303
            E+L   KS   K + +K  E+   S  L K   + P QY  L +I+K    DV LD  T
Sbjct: 256 FEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPET 315

Query: 304 AHPQLLVSEDRKAVRY-ERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKW 362
           AHP L++SEDRK+V++ E + R++   PRRF   P VL ++ F+SGRHYWEVEVG+K  W
Sbjct: 316 AHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHW 375

Query: 363 ILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYE 422
            +GVC+D + R  +  P    G+W +  +    Y A+    T L   VKP ++GIFLDYE
Sbjct: 376 AVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYE 435

Query: 423 LGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTG-----TDSEPLKICSVSDSE 470
            G LSFYN+ DRS +YTF D FTE +WP FY G      ++ PL I   +D E
Sbjct: 436 AGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 488


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score =  376 bits (966), Expect = e-104
 Identities = 205/503 (40%), Positives = 291/503 (57%), Gaps = 41/503 (8%)

Query: 6   ALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSF 65
           AL NLQ E+SC +CLEYLK+PV I CGHNFC++C++  W+DL+  FPCPVCR    Y+S 
Sbjct: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78

Query: 66  RRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKH 125
           R N QL ++ EIAKQLQ   + +++ ++ ++C +H++ L+LFC +D E +C  C+ S  H
Sbjct: 79  RPNRQLGSMVEIAKQLQ---AVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135

Query: 126 QKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINS 185
           + H + P+  A   ++E L+  LEPL   ++ + +    +  K  ELK+ VE +R++I  
Sbjct: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195

Query: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245
           EFE++   L  EQ+++L ++++EE +IL +L EN   L D    L HL  EVEGK +QS 
Sbjct: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255

Query: 246 LELLTQAKSMHHKYQNLK--------CPE------------------------LFSFRLT 273
            E+L   KS   K    K        CP                           S  L 
Sbjct: 256 FEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELE 315

Query: 274 KYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRY-ERKKRNICYDPRR 332
           K   + P QY  L +I+K    DV LD  TAHP L++SEDRK+V++ E + R++   PRR
Sbjct: 316 KNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRR 375

Query: 333 FYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYM 392
           F   P VL ++ F+SGRHYWEVEVG+K  W +GVC+D + R  +  P    G+W +  + 
Sbjct: 376 FTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWN 435

Query: 393 KSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWPYF 452
              Y A+    T L   VKP ++GIFLDYE G LSFYN+ DRS +YTF D FTE +WP F
Sbjct: 436 GDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLF 495

Query: 453 YTG-----TDSEPLKICSVSDSE 470
           Y G      ++ PL I   +D E
Sbjct: 496 YPGIRAGRKNAAPLTIRPPTDWE 518


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  277 bits (708), Expect = 2e-74
 Identities = 163/457 (35%), Positives = 248/457 (54%), Gaps = 15/457 (3%)

Query: 10  LQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDT----FPCPVCRFCFPYKSF 65
           L+E++ CP+CL++L++PV+++CGH+FC  C+S   +  D      + CP CR  F    F
Sbjct: 10  LREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPSGF 69

Query: 66  RRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKH 125
           R N QL  L E  ++L +      R+     C +H + L+ FC +D   LC  C    +H
Sbjct: 70  RPNRQLAGLVESVRRLGLGAGPGARR-----CARHGEDLSRFCEEDEAALCWVCDAGPEH 124

Query: 126 QKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINS 185
           + H   P+++AA  ++  L+ +LE +R  +E         G K+V  K+KVE +R+    
Sbjct: 125 RTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRL 184

Query: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245
           EFE+ R FL  E++  LR+++ EE   L +L E+   L      LK L  E++ +  +  
Sbjct: 185 EFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPA 244

Query: 246 LELLTQAKSMHHKYQNLKCPELFSFRLT-KYGFSLPPQYSGLDRIIKPFQVDVILDLNTA 304
           L LL   + +  + + +   E  +  +  K    +P    G   +++ FQVDV LD  TA
Sbjct: 245 LGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIP----GRRELLRKFQVDVKLDPATA 300

Query: 305 HPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWIL 364
           HP LL++ D ++V+     R++  +P RF   P +LG Q FSSGRHYWEV VG   +W L
Sbjct: 301 HPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGL 360

Query: 365 GVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELG 424
           GVCQD L R  +  PS   G WA+     + Y+     +  LL +  P  IGIFLDYE G
Sbjct: 361 GVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAG 420

Query: 425 DLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPL 461
           ++SFYN+ D S +YTFN  F+  + PYF+   D+ PL
Sbjct: 421 EISFYNVTDGSYIYTFNQLFSGLLRPYFFI-CDATPL 456


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  275 bits (704), Expect = 5e-74
 Identities = 162/463 (34%), Positives = 246/463 (53%), Gaps = 23/463 (4%)

Query: 9   NLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRN 68
           NLQEE++C ICL+Y  DPV  +CGHNFCR C+   W   +  + CP CR   P ++ R N
Sbjct: 9   NLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPN 68

Query: 69  PQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKH 128
             L  + E+A++L              +C  H + L  FC  +L +LC  C  S +H  H
Sbjct: 69  RPLAKMAEMARRLH-----PPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAH 123

Query: 129 YICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINSEFE 188
            + P++ AA   +  LE SLE LR  ++             V  +K VE +R+ +  EFE
Sbjct: 124 RVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFE 183

Query: 189 QIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNLEL 248
           ++R  L  E++ +L+++++EE+ +L +L E    L    + L  L+ E+EG+     L L
Sbjct: 184 RLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGL 243

Query: 249 LTQAKSMHHKYQNLKC--PELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHP 306
           L   K    + Q++K   PE+    L         +  GL   ++ F+ DV LD +TA+P
Sbjct: 244 LQDIKDALRRVQDVKLQPPEVVPMELRTVC-----RVPGLVETLRRFRGDVTLDPDTANP 298

Query: 307 QLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGV 366
           +L++SEDR++V+    ++ +   P RF   P VLG +RF+SGRHYWEVEVG++  W LGV
Sbjct: 299 ELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGV 358

Query: 367 CQDCLLRNWQDQPSVLGGFWA---IGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYEL 423
           C++ + R  + + S   GFW    +G Y  S   A  P          P ++GIFLDYE 
Sbjct: 359 CRENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRD------PPRRVGIFLDYEA 412

Query: 424 GDLSFYNMNDRSILYTFNDC-FTEAVWPYFYTGTDS-EPLKIC 464
           G LSFY+  D S+L+ F +  F+  + P F   + S  P+ IC
Sbjct: 413 GHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTIC 455


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  270 bits (689), Expect = 3e-72
 Identities = 168/481 (34%), Positives = 259/481 (53%), Gaps = 29/481 (6%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60
           M     L  + EE +CPICL+   +PV+I CGH+FC+ C+S   K       CPVCR  F
Sbjct: 1   MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSV--CPVCRQRF 58

Query: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120
             K+ R N QL N+    K++     + +   +   C  H + L LFC KD + LC  C+
Sbjct: 59  LLKNLRPNRQLANMVNNLKEIS---QEAREGTQGERCAVHGERLHLFCEKDGKALCWVCA 115

Query: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180
            S KH+ H + P+++AA  ++E L+ +L  LR   E  EK+ +    K  + KK VE ++
Sbjct: 116 QSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQK 175

Query: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240
             I++EF Q + FL  E++  L++++ +E   L  L E   +L+     L+ L+ E++ +
Sbjct: 176 SRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRR 235

Query: 241 SVQSNLELLTQ-------AKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPF 293
              S LELL +       ++S + K  ++  PEL S               GL ++++  
Sbjct: 236 CHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVC----------HVPGLKKMLRTC 285

Query: 294 QVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWE 353
            V + LD +TA+P L++SEDR+ VR    +++I  +  RF   P VLG+Q F SG+HYWE
Sbjct: 286 AVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWE 345

Query: 354 VEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPS 413
           V+V  K  W LGVC+D + R      S   GFW I  + K  Y A     T L   V P 
Sbjct: 346 VDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPC 405

Query: 414 KIGIFLDYELGDLSFYNMNDR-SILYTFNDC-FTEAVWPYFYT-----GTDSEPLKICSV 466
           ++GIFLDYE G +SFYN+ D  S++Y+F++C FT  + P+F       G ++ PL +C +
Sbjct: 406 QVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPL 465

Query: 467 S 467
           +
Sbjct: 466 N 466


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  268 bits (685), Expect = 8e-72
 Identities = 162/488 (33%), Positives = 267/488 (54%), Gaps = 34/488 (6%)

Query: 10  LQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRNP 69
           LQ+E++CP+CL+Y  +P+ ++CGHN C +CL+  W   +    CP CR  FP +  R N 
Sbjct: 10  LQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNR 69

Query: 70  QLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKHY 129
            L N+T++ KQL+  R       E  +CEKH + L L+C +D   +C  C  S +H+ H 
Sbjct: 70  HLANVTQLVKQLRTERPSGPGG-EMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHS 128

Query: 130 ICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKS-VELKKKVEYKREEINSEFE 188
           + P+++A    +E ++  L+ L+  ++ ++K    QG ++  EL    + +RE+I  EFE
Sbjct: 129 VLPLEEAVEGFKEQIQNQLDHLKR-VKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFE 187

Query: 189 QIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNLEL 248
           Q+   L+  +  +L ++++ ++ I   +N  + + S  +S L  L+ ++E K  Q   EL
Sbjct: 188 QLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTREL 247

Query: 249 LTQAKSMHHKYQNLKCPE-------------LFSFRLTKYGFSLPP----QYSGLDRI-- 289
           L        + + ++ PE             +F+ +      SL        S +++I  
Sbjct: 248 LQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQE 307

Query: 290 ---IKPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFS 346
               + + VDV LD +TA+P L++S++ + VRY   ++++  +P RF + P VLGS  F 
Sbjct: 308 LREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFI 367

Query: 347 SGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGR-YMKSGYVASGPKTTQ 405
           +GRHYWEVEVG+K KW +GVC+D + R      +   GFWA+   Y K  +  + P T  
Sbjct: 368 AGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTA- 426

Query: 406 LLPVVKP-SKIGIFLDYELGDLSFYNMNDRSILYTFNDC-FTEAVWPYF---YTGTDS-E 459
            LP+  P  ++GIFLDY+ G++SFYN+ +R   +TF+   F   V PYF   Y+G  S  
Sbjct: 427 -LPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAA 485

Query: 460 PLKICSVS 467
           PL IC +S
Sbjct: 486 PLIICPMS 493


>gi|60099474 tripartite motif-containing 61 [Homo sapiens]
          Length = 209

 Score =  249 bits (636), Expect = 4e-66
 Identities = 116/177 (65%), Positives = 139/177 (78%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60
           MEFVTAL +L+ E+SCPICL+YLKDPVTI+CGHNFC SC+ +SWKDL D+FPCP C FC 
Sbjct: 1   MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC 60

Query: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120
           P + F  NPQL +LTEIAKQLQIR  KRKRQ+E  +C+KHNQ LT FC KDLE+LC +CS
Sbjct: 61  PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS 120

Query: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVE 177
            ST HQ H + PIKKAASYHR+ LE    P +  +E +EKVI +Q  KS+ELKKK+E
Sbjct: 121 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKME 177


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  245 bits (625), Expect = 7e-65
 Identities = 153/472 (32%), Positives = 247/472 (52%), Gaps = 30/472 (6%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDL---------DDTF 51
           ME V     LQEE++C ICL+Y  DPV   CGHNFCR+C+ +SW+             +F
Sbjct: 1   MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 60

Query: 52  PCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKD 111
           PCP CR   P ++   N   R LT++A+  Q     +K+     +C++H++ L LFC KD
Sbjct: 61  PCPECREMSPQRNLLPN---RLLTKVAEMAQQHPGLQKQD----LCQEHHEPLKLFCQKD 113

Query: 112 LEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVE 171
              +C  C  S +H+ H + P ++A   ++  LE  +E LR  I R   +   +     E
Sbjct: 114 QSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAE 173

Query: 172 LKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLK 231
            + KV+ +RE I  EFE++ L+L  E++ +L+ ++ EE    ++L E++  L     +L+
Sbjct: 174 WQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLE 233

Query: 232 HLLREVEGKSVQSNLELLTQAKSMHHKYQN--LKCPELFSFRLTKYGFSLPPQYSGLDRI 289
            LL ++E +S Q  L++L   K    +  N  ++CPE+      +    +P Q      +
Sbjct: 234 LLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQI----EV 289

Query: 290 IKPFQVDVILDLNTAHPQLLVSEDRKAVRY---ERKKRNICYDPRRFYVCPAVLGSQRFS 346
           ++ F  DV+ D  +A+P LL+ E R+  RY     +    C    RF   P  +G   FS
Sbjct: 290 LRGFLEDVVPDATSAYPYLLLYESRQR-RYLGSSPEGSGFC-SKDRFVAYPCAVGQTAFS 347

Query: 347 SGRHYWEV--EVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTT 404
           SGRHYWEV   +     W LGVC+D + R  +       GFW +     + Y+++    T
Sbjct: 348 SGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALT 407

Query: 405 QLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDC-FTEAVWPYFYTG 455
            ++ +  PS +GIFLD+E G++SFY+++D S L+T++   F   + P+F  G
Sbjct: 408 PVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLG 459


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  245 bits (625), Expect = 7e-65
 Identities = 153/472 (32%), Positives = 247/472 (52%), Gaps = 30/472 (6%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDL---------DDTF 51
           ME V     LQEE++C ICL+Y  DPV   CGHNFCR+C+ +SW+             +F
Sbjct: 1   MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 60

Query: 52  PCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKD 111
           PCP CR   P ++   N   R LT++A+  Q     +K+     +C++H++ L LFC KD
Sbjct: 61  PCPECREMSPQRNLLPN---RLLTKVAEMAQQHPGLQKQD----LCQEHHEPLKLFCQKD 113

Query: 112 LEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVE 171
              +C  C  S +H+ H + P ++A   ++  LE  +E LR  I R   +   +     E
Sbjct: 114 QSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAE 173

Query: 172 LKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLK 231
            + KV+ +RE I  EFE++ L+L  E++ +L+ ++ EE    ++L E++  L     +L+
Sbjct: 174 WQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLE 233

Query: 232 HLLREVEGKSVQSNLELLTQAKSMHHKYQN--LKCPELFSFRLTKYGFSLPPQYSGLDRI 289
            LL ++E +S Q  L++L   K    +  N  ++CPE+      +    +P Q      +
Sbjct: 234 LLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQI----EV 289

Query: 290 IKPFQVDVILDLNTAHPQLLVSEDRKAVRY---ERKKRNICYDPRRFYVCPAVLGSQRFS 346
           ++ F  DV+ D  +A+P LL+ E R+  RY     +    C    RF   P  +G   FS
Sbjct: 290 LRGFLEDVVPDATSAYPYLLLYESRQR-RYLGSSPEGSGFC-SKDRFVAYPCAVGQTAFS 347

Query: 347 SGRHYWEV--EVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTT 404
           SGRHYWEV   +     W LGVC+D + R  +       GFW +     + Y+++    T
Sbjct: 348 SGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALT 407

Query: 405 QLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDC-FTEAVWPYFYTG 455
            ++ +  PS +GIFLD+E G++SFY+++D S L+T++   F   + P+F  G
Sbjct: 408 PVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLG 459


>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score =  245 bits (625), Expect = 7e-65
 Identities = 168/495 (33%), Positives = 261/495 (52%), Gaps = 42/495 (8%)

Query: 5   TALVN-LQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDT----FPCPVCRFC 59
           TALV  + EE +CPIC+ +L++P++I+CGH+FC SCLS  W+   ++    + CP+CR  
Sbjct: 4   TALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAP 63

Query: 60  FPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQC 119
              ++ R N QL N+ E  + L++      +     +CE+H + L +FC +D+ I+C  C
Sbjct: 64  VQPRNLRPNWQLANVVEKVRLLRLHPGMGLK---GDLCERHGEKLKMFCKEDVLIMCEAC 120

Query: 120 SFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYK 179
           S S +H+ H + P++  A  ++  L  +LE L+   E   K+ + +  ++   K +VE +
Sbjct: 121 SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR 180

Query: 180 REEINSEFEQIRLFLQNEQE----------MILRQIQDEEMNILAKLNENLVELSDYVST 229
           ++ I  EFE+ +  L+ +Q             L  +Q E    + KL  N  EL      
Sbjct: 181 KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV 240

Query: 230 LKHLLREVEGKS-------VQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQ 282
           L  ++ E++ +S       +Q   E+L ++KS      +L+ PE  S  L         +
Sbjct: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSW-----SLQQPEPISLEL-----KTDCR 290

Query: 283 YSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGS 342
             GL  I+K +  DV LD +TA+ +L+VSEDRK V Y    + +  +P RFY    VLGS
Sbjct: 291 VLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGS 350

Query: 343 QRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPK 402
           Q  SSGRHYWEVEVG++ +W LGVC+  + R      S   GFW I     + Y A   +
Sbjct: 351 QCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDE 410

Query: 403 TTQLLPVVKPSKIGIFLDYELGDLSFYNMND-RSILYTF-NDCFTEAVWPYF----YTGT 456
              L   V P ++GIF+DYE  D+SFYN+ D  S ++TF    F   + PYF      GT
Sbjct: 411 YPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGT 470

Query: 457 -DSEPLKICSVSDSE 470
            ++ PL ICS+   +
Sbjct: 471 NNTAPLAICSLDGED 485


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  239 bits (609), Expect = 5e-63
 Identities = 158/497 (31%), Positives = 259/497 (52%), Gaps = 51/497 (10%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD----LDDTFPCPVCRFCFPY 62
           L+N+QEE +CPICLE L +P++++CGH+ CR+C++VS K+    +     CPVC   + +
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
           +  + N  L N+ E  K++++     K++    +C+ H + L LFC +D +++C  C  S
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 122

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+    ++     +E L+  L+ L+   E  EK+      +    K +V+ +R+ 
Sbjct: 123 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 182

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF+Q+R  L NE++  L+++++EE   L K  E   EL      ++ L+ +VE +S 
Sbjct: 183 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 242

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQ------ 294
            S +ELL     +    +   LK P++ S +L K  F  P     L R+++ F+      
Sbjct: 243 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKL-KTVFHAP----DLSRMLQMFRELTAVR 297

Query: 295 ---VDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHY 351
              VDV L+    +  L++SED++ V         CY+         VLGSQ FSSG+HY
Sbjct: 298 CYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYN-------YGVLGSQYFSSGKHY 350

Query: 352 WEVEVGNKPKWILG------------VCQDCLLR-NWQDQPSVLGGFWAIGRYMKSGY-- 396
           WEV+V  K  WILG            V + C  R N   +   L G+W IG   K  Y  
Sbjct: 351 WEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGV 410

Query: 397 ----VASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDR-SILYTFND-CFTEAVWP 450
               ++S P+   L   V P ++G+FLDYE G +SF+N+    S++Y F+  CF++ V+P
Sbjct: 411 FEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYP 470

Query: 451 YFYTGTDSEPLKICSVS 467
           YF       P+ +C  S
Sbjct: 471 YFNPWNCPAPMTLCPPS 487


>gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  239 bits (609), Expect = 5e-63
 Identities = 158/497 (31%), Positives = 259/497 (52%), Gaps = 51/497 (10%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD----LDDTFPCPVCRFCFPY 62
           L+N+QEE +CPICLE L +P++++CGH+ CR+C++VS K+    +     CPVC   + +
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
           +  + N  L N+ E  K++++     K++    +C+ H + L LFC +D +++C  C  S
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 122

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+    ++     +E L+  L+ L+   E  EK+      +    K +V+ +R+ 
Sbjct: 123 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 182

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF+Q+R  L NE++  L+++++EE   L K  E   EL      ++ L+ +VE +S 
Sbjct: 183 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 242

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQ------ 294
            S +ELL     +    +   LK P++ S +L K  F  P     L R+++ F+      
Sbjct: 243 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKL-KTVFHAP----DLSRMLQMFRELTAVR 297

Query: 295 ---VDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHY 351
              VDV L+    +  L++SED++ V         CY+         VLGSQ FSSG+HY
Sbjct: 298 CYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYN-------YGVLGSQYFSSGKHY 350

Query: 352 WEVEVGNKPKWILG------------VCQDCLLR-NWQDQPSVLGGFWAIGRYMKSGY-- 396
           WEV+V  K  WILG            V + C  R N   +   L G+W IG   K  Y  
Sbjct: 351 WEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGV 410

Query: 397 ----VASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDR-SILYTFND-CFTEAVWP 450
               ++S P+   L   V P ++G+FLDYE G +SF+N+    S++Y F+  CF++ V+P
Sbjct: 411 FEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYP 470

Query: 451 YFYTGTDSEPLKICSVS 467
           YF       P+ +C  S
Sbjct: 471 YFNPWNCPAPMTLCPPS 487


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  239 bits (609), Expect = 5e-63
 Identities = 158/497 (31%), Positives = 259/497 (52%), Gaps = 51/497 (10%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD----LDDTFPCPVCRFCFPY 62
           L+N+QEE +CPICLE L +P++++CGH+ CR+C++VS K+    +     CPVC   + +
Sbjct: 360 LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 419

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
           +  + N  L N+ E  K++++     K++    +C+ H + L LFC +D +++C  C  S
Sbjct: 420 EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 476

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+    ++     +E L+  L+ L+   E  EK+      +    K +V+ +R+ 
Sbjct: 477 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 536

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF+Q+R  L NE++  L+++++EE   L K  E   EL      ++ L+ +VE +S 
Sbjct: 537 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 596

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQ------ 294
            S +ELL     +    +   LK P++ S +L K  F  P     L R+++ F+      
Sbjct: 597 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKL-KTVFHAP----DLSRMLQMFRELTAVR 651

Query: 295 ---VDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHY 351
              VDV L+    +  L++SED++ V         CY+         VLGSQ FSSG+HY
Sbjct: 652 CYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYN-------YGVLGSQYFSSGKHY 704

Query: 352 WEVEVGNKPKWILG------------VCQDCLLR-NWQDQPSVLGGFWAIGRYMKSGY-- 396
           WEV+V  K  WILG            V + C  R N   +   L G+W IG   K  Y  
Sbjct: 705 WEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGV 764

Query: 397 ----VASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDR-SILYTFND-CFTEAVWP 450
               ++S P+   L   V P ++G+FLDYE G +SF+N+    S++Y F+  CF++ V+P
Sbjct: 765 FEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYP 824

Query: 451 YFYTGTDSEPLKICSVS 467
           YF       P+ +C  S
Sbjct: 825 YFNPWNCPAPMTLCPPS 841



 Score =  137 bits (346), Expect = 2e-32
 Identities = 76/272 (27%), Positives = 146/272 (53%), Gaps = 9/272 (3%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDL----DDTFPCPVCRFCFPY 62
           LV+++EE +CPICLE L +P++I+CGH+FC++C++ + ++     +    CPVC+  +  
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
            + R N  L N+    +++ +   K   Q +  +C  H + L LFC +D +++C  C  S
Sbjct: 94  GNLRPNRHLANIVRRLREVVLGPGK---QLKAVLCADHGEKLQLFCQEDGKVICWLCERS 150

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+   +++ A  ++E  + SL+ L+N  +  EK+      K    K ++E +R  
Sbjct: 151 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 210

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF Q+R  L   ++  L++++ EE   L  + E   +L     +L+ L+ ++E +  
Sbjct: 211 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 270

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRL 272
            S +ELL     +    ++  L+ PE    +L
Sbjct: 271 GSTMELLQDVSDVTERSEFWTLRKPEALPTKL 302


>gi|5454014 tripartite motif-containing 38 [Homo sapiens]
          Length = 465

 Score =  230 bits (586), Expect = 2e-60
 Identities = 142/460 (30%), Positives = 235/460 (51%), Gaps = 18/460 (3%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD------LDDTFPCP 54
           M   T+   + EE++C ICL  + +PV+INCGH++C  C++  +K+        +TF CP
Sbjct: 1   MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP 60

Query: 55  VCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEI 114
            CR  F   S R N QL +L E  K+     S          CE+H +   LFC  + ++
Sbjct: 61  QCRAPFHMDSLRPNKQLGSLIEALKETDQEMS----------CEEHGEQFHLFCEDEGQL 110

Query: 115 LCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKK 174
           +C +C  + +H+ H    ++     ++E L+ ++  L+   +R  +  +    +  + K+
Sbjct: 111 ICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKE 170

Query: 175 KVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLL 234
           KV+ +R++I S+F+ ++ FL  E++  L +++ EE   L++L +    L    + LK  +
Sbjct: 171 KVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHI 230

Query: 235 REVEGKSVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGF-SLPPQYSGLDRIIKPF 293
            E+E K   S  +LL        +   +K     +  L  +   ++   Y  + ++++  
Sbjct: 231 LELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSH 290

Query: 294 QVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWE 353
           QV V LD +TAH +L++SEDR+ V     + N     RRF   P VLG + F+SGR Y+E
Sbjct: 291 QVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFE 350

Query: 354 VEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPS 413
           V+VG    W LGVC + + R    +     GFW +    K GYVA     T L    +P 
Sbjct: 351 VDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPL 410

Query: 414 KIGIFLDYELGDLSFYNMNDRSILYTF-NDCFTEAVWPYF 452
            +GIFLDYE G +SFYN N    ++TF    F++ + PYF
Sbjct: 411 LVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYF 450


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  226 bits (576), Expect = 3e-59
 Identities = 143/473 (30%), Positives = 247/473 (52%), Gaps = 33/473 (6%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDL----DDTFPCPVCRFCFPY 62
           LV+++EE +CPICLE L +P++I+CGH+FC++C++ + ++     +    CPVC+  +  
Sbjct: 6   LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 65

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
            + R N  L N+    +++ +   K   Q +  +C  H + L LFC +D +++C  C  S
Sbjct: 66  GNLRPNRHLANIVRRLREVVLGPGK---QLKAVLCADHGEKLQLFCQEDGKVICWLCERS 122

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+   +++ A  ++E  + SL+ L+N  +  EK+      K    K ++E +R  
Sbjct: 123 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 182

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF Q+R  L   ++  L++++ EE   L  + E   +L     +L+ L+ ++E +  
Sbjct: 183 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 242

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRI------IKPFQ 294
            S +ELL     +    ++  L+ PE    +L        P    + R+      ++ + 
Sbjct: 243 GSTMELLQDVSDVTERSEFWTLRKPEALPTKLR--SMFRAPDLKRMLRVCRELTDVQSYW 300

Query: 295 VDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEV 354
           VDV L+ +TA+  L+++++R+ VR+   K +      + Y C +VLGSQ FSSG+HYWEV
Sbjct: 301 VDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDC-SVLGSQHFSSGKHYWEV 359

Query: 355 EVGNKPKWILGVCQDCL-----LRNWQDQPSVL------GGFWAIGRYMKSGYVASGPKT 403
           +V  K  WILGVC + L       ++    S         G+W IG      Y A    +
Sbjct: 360 DVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSS 419

Query: 404 TQLL--PVVKPSKIGIFLDYELGDLSFYNMNDRSI-LYTFND-CFTEAVWPYF 452
             LL    V P ++G+FLDYE G +SFYN+ +    +YTF+   F   + PYF
Sbjct: 420 PSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYF 472


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  226 bits (576), Expect = 3e-59
 Identities = 143/473 (30%), Positives = 247/473 (52%), Gaps = 33/473 (6%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDL----DDTFPCPVCRFCFPY 62
           LV+++EE +CPICLE L +P++I+CGH+FC++C++ + ++     +    CPVC+  +  
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  KSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFS 122
            + R N  L N+    +++ +   K   Q +  +C  H + L LFC +D +++C  C  S
Sbjct: 94  GNLRPNRHLANIVRRLREVVLGPGK---QLKAVLCADHGEKLQLFCQEDGKVICWLCERS 150

Query: 123 TKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREE 182
            +H+ H+   +++ A  ++E  + SL+ L+N  +  EK+      K    K ++E +R  
Sbjct: 151 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 210

Query: 183 INSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSV 242
           I +EF Q+R  L   ++  L++++ EE   L  + E   +L     +L+ L+ ++E +  
Sbjct: 211 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 270

Query: 243 QSNLELLTQAKSM--HHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRI------IKPFQ 294
            S +ELL     +    ++  L+ PE    +L        P    + R+      ++ + 
Sbjct: 271 GSTMELLQDVSDVTERSEFWTLRKPEALPTKLR--SMFRAPDLKRMLRVCRELTDVQSYW 328

Query: 295 VDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEV 354
           VDV L+ +TA+  L+++++R+ VR+   K +      + Y C +VLGSQ FSSG+HYWEV
Sbjct: 329 VDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDC-SVLGSQHFSSGKHYWEV 387

Query: 355 EVGNKPKWILGVCQDCL-----LRNWQDQPSVL------GGFWAIGRYMKSGYVASGPKT 403
           +V  K  WILGVC + L       ++    S         G+W IG      Y A    +
Sbjct: 388 DVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSS 447

Query: 404 TQLL--PVVKPSKIGIFLDYELGDLSFYNMNDRSI-LYTFND-CFTEAVWPYF 452
             LL    V P ++G+FLDYE G +SFYN+ +    +YTF+   F   + PYF
Sbjct: 448 PSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYF 500


>gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo
           sapiens]
          Length = 493

 Score =  225 bits (573), Expect = 8e-59
 Identities = 146/496 (29%), Positives = 250/496 (50%), Gaps = 44/496 (8%)

Query: 7   LVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD--LDD-TFPCPVCRFCFPYK 63
           LVN++EE +CPICLE L  P++++CGH+FC++CL+ + K   LD     CPVCR  +  +
Sbjct: 6   LVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPE 65

Query: 64  SFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFST 123
           + R N  + NL E  +++++    +K       C +H + L LFC +D +++C  C  S 
Sbjct: 66  NIRPNRHVANLVEKLREVKLSPEGQKVDH----CARHGEKLLLFCQEDGKVICWLCERSQ 121

Query: 124 KHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEI 183
           +H+ H+  P ++ A  ++  L+ +LE LR   +  E++      +    K +++Y +  +
Sbjct: 122 EHRGHHTFPTEEVAQEYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNV 181

Query: 184 NSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQ 243
            ++FEQ+R  L  E+   L+ ++ EE +IL  L  +  E+     +L+ L+ ++E +   
Sbjct: 182 LADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQG 241

Query: 244 SNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRI------IKPFQVDV 297
           S +ELL     +  + +N+   +  +F   +      P   G+  +      ++ + VDV
Sbjct: 242 SVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELTDVRRYWVDV 301

Query: 298 ILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPR--------RFYVCPAVLGSQRFSSGR 349
            +  N      ++SED++ V     K  I Y  R         F  C  +LGSQ  +SG+
Sbjct: 302 TVAPNNI-SCAVISEDKRQV--SSPKPQIIYGARGTRYQTFVNFNYCTGILGSQSITSGK 358

Query: 350 HYWEVEVGNKPKWILGVCQDC-------LLRNWQDQPSVLGGFWAIGR---------YMK 393
           HYWEV+V  K  WILGVC          + +N   QP    G+W IG             
Sbjct: 359 HYWEVDVSKKTAWILGVCAGFQPDAMCNIEKNENYQPKY--GYWVIGLEEGVKCSAFQDS 416

Query: 394 SGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNM-NDRSILYTFNDC-FTEAVWPY 451
           S +  S P    L  ++ P ++G+FLDYE   +SF+N+ N   ++Y F+ C F++ V+PY
Sbjct: 417 SFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPY 476

Query: 452 FYTGTDSEPLKICSVS 467
                   P+ +CS S
Sbjct: 477 LNPRKCGVPMTLCSPS 492


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  223 bits (569), Expect = 2e-58
 Identities = 148/480 (30%), Positives = 248/480 (51%), Gaps = 28/480 (5%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60
           M     + NL+EE +C ICL+Y   PVT  CGH+FC  CL  SW++ +    CP C    
Sbjct: 1   MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTL 60

Query: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120
               F+ N +L  L  IA+QL+     +  Q E+          T   + D E       
Sbjct: 61  EGPHFQSNERLGRLASIARQLR----SQVLQSEDEQGSYGRMPTTAKALSDDE-QGGSAF 115

Query: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180
            +  H  + +    +A  +HRE L+  L  LR   +  + V+  +  +    +++ +  +
Sbjct: 116 VAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCK 175

Query: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240
           + + SE+ ++  FL+ E+++ L+ ++ EE   + KL  N ++L+  + +L  ++ ++E  
Sbjct: 176 QVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESS 235

Query: 241 SVQSNLELLTQAKSMHHKYQNL--KCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVI 298
           S  S  E L + +    + + L  +CPE  +  L+        + +G+  +++ F  ++ 
Sbjct: 236 SQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLC------RITGMKEMLRKFSTEIT 289

Query: 299 LDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGN 358
           LD  TA+  L++SED K+V+Y   ++ +  +P RF     VLG+Q F+SGRHYWEVEVGN
Sbjct: 290 LDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWEVEVGN 349

Query: 359 KPKWILGVCQDCLLR--NWQDQPSVLGGFWAIGRYMKSGY---VASGPKTTQLLPVVKPS 413
           K +W +G+C+D + R  N    P  L  F  IG  +   Y   V+S  K   +   V   
Sbjct: 350 KTEWEVGICKDSVSRKGNLPKPPGDL--FSLIGLKIGDDYSLWVSSPLKGQHVREPV--C 405

Query: 414 KIGIFLDYELGDLSFYNMNDRSILYTFNDC-FTEAVWPYF-----YTGTDSEPLKICSVS 467
           K+G+FLDYE G ++FYN  D S++Y+F    F EA+ P F       GT+++PL ICS++
Sbjct: 406 KVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTICSLN 465


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  223 bits (568), Expect = 3e-58
 Identities = 134/449 (29%), Positives = 222/449 (49%), Gaps = 35/449 (7%)

Query: 51  FPCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVK 110
           F CP CR  FP +SFR N QL N+ ++ +Q+     +  R  +  +C KH + L LFC  
Sbjct: 181 FTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEV 240

Query: 111 DLEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSV 170
           D E +C  C  S  H++H + P+++    ++  L+G +EPLR ++E V+K+   +  +  
Sbjct: 241 DEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVT 300

Query: 171 ELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTL 230
           ELK +++ +   + SEF ++  FL  EQ  + R++++     L +       L++  + L
Sbjct: 301 ELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQL 360

Query: 231 KHLLREVEGKSVQSNLELLTQAKSMHHKYQ--NLKCPELFS---FRLTKYGFSLPPQYSG 285
             LL E + +S Q  L LL   K   ++ +   L+ PE++S    +   + F        
Sbjct: 361 SRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRK 420

Query: 286 LDRII-KPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQR 344
           + R+  +  +VD+ LD +TAHP L++S DR+ VR   +++ +   P+RF     VLG+Q 
Sbjct: 421 MSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQG 480

Query: 345 FSSGRHYWEVEVGNKPKWILGVCQDCLLR----------------------------NWQ 376
           F SGRHYWEVEVG +  W +G  ++                                +  
Sbjct: 481 FRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLP 540

Query: 377 DQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSI 436
            QP +    W +G   K     S  + T L P  KP + G++LDYE G L FYN    + 
Sbjct: 541 QQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAH 600

Query: 437 LYTFNDCFT-EAVWPYFYTGTDSEPLKIC 464
           ++TF+  F  E V+P+F   +    +K+C
Sbjct: 601 VHTFSAAFLGERVFPFFRVLSKGTRIKLC 629



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 23/40 (57%), Positives = 29/40 (72%)

Query: 10 LQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDD 49
          LQEE+ C ICL+Y  DPV+I CGHNFCR C++  W   D+
Sbjct: 14 LQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDE 53


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  217 bits (553), Expect = 2e-56
 Identities = 152/471 (32%), Positives = 242/471 (51%), Gaps = 43/471 (9%)

Query: 9   NLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRN 68
           ++QEE +CPICL+Y +DPV+I CGHNFCR CL  +W      FPCP CR      + R N
Sbjct: 5   DIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPN 64

Query: 69  PQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKH 128
             L  LTE  ++      +R       +C +H + L LFC  D   +C  C  S +HQ H
Sbjct: 65  WALARLTEKTQR------RRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTH 118

Query: 129 YICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQG---SKSVELKKKVEYKREEINS 185
            + PI +A   +RE L   L+  RN + +++KV+ LQ      + + K K++ +R  I++
Sbjct: 119 AMAPIDEAFESYREKL---LKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRIST 175

Query: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245
           EF ++  FL  E+++ L+++  EE     KLNEN ++L+  +++LK L+ EV  KS    
Sbjct: 176 EFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPT 235

Query: 246 LELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNTAH 305
           LELL   K +  + +     +  ++ L         Q   +  ++K FQV V L  +TAH
Sbjct: 236 LELLQNPKEVLTRSE----IQDVNYSLEAVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAH 291

Query: 306 PQLLVSEDRKAVRYE-------------------RKKRNICYDPRRFYVCPAVLGSQRFS 346
           P+L+ S++ + V+                     R  +   +   RF   P VLG   F+
Sbjct: 292 PKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAF-VERFQHLPCVLGKNVFT 350

Query: 347 SGRHYWEVEVGNKPKWILGVC-QDCLLRNWQDQPSVLGGFWAIGRYMKSGY--VASGPKT 403
           SG+HYWEVE  +  +  +GVC +D +    + + S   G WAI  +  +GY  +   P T
Sbjct: 351 SGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAI-YWSAAGYWPLIGFPGT 409

Query: 404 -TQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWPYFY 453
            TQ  P +   ++G++LD   G++SFY+  D   L+TF+      + P+F+
Sbjct: 410 PTQQEPAL--HRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFW 458


>gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]
          Length = 450

 Score =  216 bits (550), Expect = 4e-56
 Identities = 138/442 (31%), Positives = 229/442 (51%), Gaps = 30/442 (6%)

Query: 31  CGHNFCRSCLSVSWKDL---------DDTFPCPVCRFCFPYKSFRRNPQLRNLTEIAKQL 81
           CGHNFCR+C+ +SW+             +FPCP CR   P ++   N   R LT++A+  
Sbjct: 4   CGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPN---RLLTKVAEMA 60

Query: 82  QIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKHYICPIKKAASYHR 141
           Q     +K+     +C++H++ L LFC KD   +C  C  S +H+ H + P ++A   ++
Sbjct: 61  QQHPGLQKQD----LCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYK 116

Query: 142 EILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMI 201
             LE  +E LR  I R   +   +     E + KV+ +RE I  EFE++ L+L  E++ +
Sbjct: 117 LKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRL 176

Query: 202 LRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQN 261
           L+ ++ EE    ++L E++  L     +L+ LL ++E +S Q  L++L   K    +  N
Sbjct: 177 LQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNN 236

Query: 262 --LKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRY 319
             ++CPE+      +    +P Q      +++ F  DV+ D  +A+P LL+ E R+  RY
Sbjct: 237 VSVQCPEVAPPTRPRTVCRVPGQI----EVLRGFLEDVVPDATSAYPYLLLYESRQR-RY 291

Query: 320 ---ERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEV--EVGNKPKWILGVCQDCLLRN 374
                +    C    RF   P  +G   FSSGRHYWEV   +     W LGVC+D + R 
Sbjct: 292 LGSSPEGSGFC-SKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRK 350

Query: 375 WQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDR 434
            +       GFW +     + Y+++    T ++ +  PS +GIFLD+E G++SFY+++D 
Sbjct: 351 DRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDG 410

Query: 435 SILYTFNDC-FTEAVWPYFYTG 455
           S L+T++   F   + P+F  G
Sbjct: 411 SHLHTYSQATFPGPLQPFFCLG 432


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  213 bits (541), Expect = 4e-55
 Identities = 141/472 (29%), Positives = 247/472 (52%), Gaps = 24/472 (5%)

Query: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLS----VSWKDLDDTFPCPVC 56
           M    ++ +L +E +CPIC   L++PVTI+CGHNFCR+CL+    +   DL+++  CP+C
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC 60

Query: 57  RFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILC 116
           +  F   SFR N QL N+ E  ++LQ+  +    +++  +C++H + +  FC  D   LC
Sbjct: 61  KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEED--VCQEHGEKIYFFCEDDEMQLC 118

Query: 117 TQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKV 176
             C  + +H  H +  ++ AA+ +RE +   L+ LR   E ++++   +  +   L  +V
Sbjct: 119 VVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQV 178

Query: 177 EYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLRE 236
             KR+++ SEF  +R FL+ +Q ++L Q++ ++ +IL + +E  + ++  +     L+ E
Sbjct: 179 STKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEE 238

Query: 237 VEGKSVQSNLELLTQAKSMHHKYQNLKC--PELFSFRLTKYGFSLPPQYSGLDRIIKPF- 293
           +E K+ +   ELLT  +S   + +  KC  P   S  L +     P Q   L R +K F 
Sbjct: 239 LEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFL 298

Query: 294 ----------QVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQ 343
                        + LD  T+HP+LL+SED +  ++  K +N   +P+RF     VL   
Sbjct: 299 EKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHT 358

Query: 344 RFSSGRHYW--EVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYV-ASG 400
             + GRH W   +++ +     +GV  + + R  + +     G WA+   +  G+V A G
Sbjct: 359 GITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAV--RLAWGFVSALG 416

Query: 401 PKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWPYF 452
              T+L    +P ++ + LDYE+G ++F N   R  +YTF   FT  V P+F
Sbjct: 417 SFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFF 468


>gi|117938316 tripartite motif-containing 22 [Homo sapiens]
          Length = 498

 Score =  211 bits (537), Expect = 1e-54
 Identities = 156/503 (31%), Positives = 256/503 (50%), Gaps = 55/503 (10%)

Query: 8   VNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKD----LDDTFPCPVCRFCFPYK 63
           V++++E +CPICLE L +P++++CGH+FC++C++   K+          CPVC+  F   
Sbjct: 7   VDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPG 66

Query: 64  SFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFST 123
           + R N  L N+ E  K  +++ S ++ QK + +CE H + L +FC +D +++C  C  S 
Sbjct: 67  NLRPNRHLANIVERVK--EVKMSPQEGQKRD-VCEHHGKKLQIFCKEDGKVICWVCELSQ 123

Query: 124 KHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEI 183
           +HQ H    I +     +E L+ +L+ L    +  EK+      +    K  ++ +R++I
Sbjct: 124 EHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKI 183

Query: 184 NSEFEQIRLFLQNEQEMILRQIQDEEMNI---LAKLNENLVELSDYVSTL-KHLLREVEG 239
              F ++R+ L NE++  L+++++ E+N+   LA   + LV+     STL   L R + G
Sbjct: 184 LKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRG 243

Query: 240 KSVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKP------F 293
            SV+   +++   K    +   LK P+  S +L K  F + P  SG+ +++K       +
Sbjct: 244 SSVEMLQDVIDVMK--RSESWTLKKPKSVSKKL-KSVFRV-PDLSGMLQVLKELTDVQYY 299

Query: 294 QVDVILDLNTAHPQLLVSEDRKAVRYER----KKRNICYDPRRFYVCPAVLGSQRFSSGR 349
            VDV+L+  +A   + +S D++ V+  R    K  N C D   F     V G Q FSSG+
Sbjct: 300 WVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPC-DFSAF----GVFGCQYFSSGK 354

Query: 350 HYWEVEVGNKPKWILGVCQDCLLRN------WQDQPSV-----------LGGFWAIGRYM 392
           +YWEV+V  K  WILGV       N      +   PSV             G+W IG   
Sbjct: 355 YYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQN 414

Query: 393 KSGYVA------SGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNM-NDRSILYTFNDC-F 444
              Y A      S PK   L   V P +IG+FLDYE G +SF+N+ N  +++Y F+ C F
Sbjct: 415 TCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRF 474

Query: 445 TEAVWPYFYTGTDSEPLKICSVS 467
           +   +PYF       P+ +C  S
Sbjct: 475 SRPAYPYFNPWNCLVPMTVCPPS 497


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  211 bits (536), Expect = 1e-54
 Identities = 136/496 (27%), Positives = 240/496 (48%), Gaps = 35/496 (7%)

Query: 2   EFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDD------------ 49
           E +     LQ E++C ICLE  ++PV++ CGH+FCR+C+   W+                
Sbjct: 15  EALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAATRAPPF 74

Query: 50  TFPCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAM--------CEKHN 101
             PCP CR        R N QL  +  + ++  +  +        A         C +H 
Sbjct: 75  PLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHG 134

Query: 102 QFLTLFCVKDLEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKV 161
           +   L+C  D   +C  C  + +H++H + P+ +A    +E+LE  L  L+  +E  E  
Sbjct: 135 EPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVF 194

Query: 162 IILQGSKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLV 221
              +  +S EL K++  ++E++ +EF+ +R FL  ++  +L ++++    +  K NENL 
Sbjct: 195 RSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLA 254

Query: 222 ELSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQNLKCPE--LFSFRLTKYGFSL 279
           +L   ++ L  L  +++  + + +L+ L + KS   +  N+  P+    S  +    +++
Sbjct: 255 QLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWNV 314

Query: 280 PPQYSGLDRIIKPF------------QVDVILDLNTAHPQLLVSEDRKAVRYERKKRNIC 327
             +   L  ++K F            +V++ LD +TA+P+L++S D K VR   + +++ 
Sbjct: 315 SLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLP 374

Query: 328 YDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWA 387
             P RF     VL S  FSSGRH+WEVEVG+K  W  GV ++ + R      +   G WA
Sbjct: 375 NHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWA 434

Query: 388 IGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEA 447
           +       +  + P+ +  L     S++ + LD E+G +SFY + D   LYTF   F E 
Sbjct: 435 LQLNGGQYWAVTSPERSP-LSCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQER 493

Query: 448 VWPYFYTGTDSEPLKI 463
           V+P F   +    L+I
Sbjct: 494 VFPLFSVCSTGTYLRI 509


>gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo
           sapiens]
          Length = 500

 Score =  209 bits (532), Expect = 4e-54
 Identities = 152/494 (30%), Positives = 242/494 (48%), Gaps = 63/494 (12%)

Query: 9   NLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRN 68
           ++QEE +CPICL+Y +DPV+I CGHNFCR CL  +W      FPCP CR      + R N
Sbjct: 5   DIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPN 64

Query: 69  PQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKH 128
             L  LTE  ++      +R       +C +H + L LFC  D   +C  C  S +HQ H
Sbjct: 65  WALARLTEKTQR------RRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTH 118

Query: 129 YICPIKKAAS-----------------------YHREILEGSLEPLRNNIERVEKVIILQ 165
            + PI +A                         YH +  E  L+  RN + +++KV+ LQ
Sbjct: 119 AMAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHSKQEEKLLKSQRNLVAKMKKVMHLQ 178

Query: 166 G---SKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVE 222
                 + + K K++ +R  I++EF ++  FL  E+++ L+++  EE     KLNEN ++
Sbjct: 179 DVEVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLK 238

Query: 223 LSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQ 282
           L+  +++LK L+ EV  KS    LELL   K +  + +     +  ++ L         Q
Sbjct: 239 LNQTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSE----IQDVNYSLEAVKVKTVCQ 294

Query: 283 YSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRYE-------------------RKK 323
              +  ++K FQV V L  +TAHP+L+ S++ + V+                     R  
Sbjct: 295 IPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNP 354

Query: 324 RNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVC-QDCLLRNWQDQPSVL 382
           +   +   RF   P VLG   F+SG+HYWEVE  +  +  +GVC +D +    + + S  
Sbjct: 355 QKTAF-VERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPD 413

Query: 383 GGFWAIGRYMKSGY--VASGPKT-TQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYT 439
            G WAI  +  +GY  +   P T TQ  P +   ++G++LD   G++SFY+  D   L+T
Sbjct: 414 VGIWAI-YWSAAGYWPLIGFPGTPTQQEPAL--HRVGVYLDRGTGNVSFYSAVDGVHLHT 470

Query: 440 FNDCFTEAVWPYFY 453
           F+      + P+F+
Sbjct: 471 FSCSSVSRLRPFFW 484


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score =  207 bits (528), Expect = 1e-53
 Identities = 137/468 (29%), Positives = 231/468 (49%), Gaps = 26/468 (5%)

Query: 13  ESSCPICLEYLKDPVTINCGHNFCRSCLSVSWK-DLDDTFPCPVCRFCFPYKSFRRNPQL 71
           E  CP+C ++ +DP+ ++CGHNFC +C+   W+    +TF CP C+    Y +   NP L
Sbjct: 38  ELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETF-CPECKMLCQYNNCTFNPVL 96

Query: 72  RNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS---FSTKHQKH 128
             L E  K+L +        K +  C +H + L LF   D +++C QC     S    K 
Sbjct: 97  DKLVEKIKKLPLL-------KGHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKE 149

Query: 129 YICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINSEFE 188
           ++  I  A  +  E L      L   ++ ++ +  +Q       K+   + ++ ++ EF 
Sbjct: 150 FL-QISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFL 208

Query: 189 QIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNL-- 246
           ++  FL ++++ IL ++++E   +  ++  NL +L +     K +L  ++ K+ Q N   
Sbjct: 209 KLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFD 268

Query: 247 ---ELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYS---GLDRIIKPFQVDVILD 300
              ++ T   S+    + L   EL S +L    +  P QY     +   + P    + LD
Sbjct: 269 FLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLD 328

Query: 301 LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP 360
             TAHP L++S+ + +V +   K+ +  DP RF    AVLGS+ F+SG+ YWEVEV  K 
Sbjct: 329 PKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKT 388

Query: 361 KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD 420
           KW +GV ++ ++R      +   GFW +    ++   A    +  L       K+GI+LD
Sbjct: 389 KWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLD 448

Query: 421 YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYT-----GTDSEPLKI 463
           YE G LSFYN    + +YTF++ F E ++PYF       G + EPL I
Sbjct: 449 YEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHI 496


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score =  192 bits (487), Expect = 7e-49
 Identities = 128/406 (31%), Positives = 195/406 (48%), Gaps = 41/406 (10%)

Query: 97  CEKH-NQFLTLFCVKDLEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNI 155
           C++H  Q   LFC    E +C  CS S +HQ H + PI++ A  H++ ++  LE L+   
Sbjct: 375 CKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLR 434

Query: 156 ERVEKVIILQGSKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAK 215
           +  E+       K+V   K+ E  ++ +  + EQ+  FL+ ++   +  ++D    +   
Sbjct: 435 KSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVGQMVGQI 494

Query: 216 LNENLVELSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQNLKCPEL-------- 267
                  +S  ++ L  L+ E+E K  QS  ELL     + H+ + +  PE         
Sbjct: 495 RKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIK 554

Query: 268 -----------FSFRLTKYG----------FSLPPQYSGLDRIIKPFQVDVILDLNTAHP 306
                      F  + TKY           F++P          +   V+VILD  TA+P
Sbjct: 555 QKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGA-----QAHAVNVILDAETAYP 609

Query: 307 QLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGV 366
            L+ S+D K+VR   K   +   P+RF  C  VLGS  F SGR YWEVEVG+K  WILG 
Sbjct: 610 NLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGA 669

Query: 367 CQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDL 426
           C+  + R      S   G+W +    ++ Y AS    T+LL    P ++GIF+DY +G +
Sbjct: 670 CKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSI 729

Query: 427 SFYNMNDRSILYTFNDC-FTEAVWPYFYTGT-----DSEPLKICSV 466
           SFYN+  RS +YTF  C F+  + P F  GT     ++ PL IC V
Sbjct: 730 SFYNVTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICPV 775


>gi|20270353 tripartite motif-containing 43 [Homo sapiens]
          Length = 446

 Score =  189 bits (479), Expect = 6e-48
 Identities = 130/451 (28%), Positives = 219/451 (48%), Gaps = 22/451 (4%)

Query: 11  QEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRNPQ 70
           Q+E +C ICL YL DPVTI CGH+FCR CL +SW++      CP CR   P   F+ N  
Sbjct: 10  QKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWEEAQSPANCPACREPSPKMDFKTNIL 69

Query: 71  LRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKHYI 130
           L+NL  IA++  + +       E  +C  H Q   +FC  D  +LC  CS S +H  H  
Sbjct: 70  LKNLVTIARKASLWQF---LSSEKQICGTHRQTKKMFCDMDKSLLCLLCSNSQEHGAHKH 126

Query: 131 CPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINSEFEQI 190
            PI++AA  HRE L   +  L   I+  ++ +  +G  +   +  V  + + I +E+ ++
Sbjct: 127 HPIEEAAEEHREKLLKQMRILWKKIQENQRNLYEEGRTAFLWRGNVVLRAQMIRNEYRKL 186

Query: 191 RLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNLELLT 250
              L  E++  L ++  E   I  +L  + V++      LK + +E+     + ++ELL 
Sbjct: 187 HPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKPDVELLQ 246

Query: 251 QAKSMHHKYQN--LKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHPQL 308
               +  + ++  L  P+  +  LT          +GL   +  F+V++       +  +
Sbjct: 247 DLGDIVARSESVLLHMPQPVNPELT------AGPITGLVYRLNRFRVEISFHFEVTNHNI 300

Query: 309 LVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQ 368
            + ED ++  + R   N     R  Y   A  G++ FS G+HYWE++V N   W LGVC 
Sbjct: 301 RLFEDVRSWMFRRGPLN---SDRSDYF--AAWGARVFSFGKHYWELDVDNSCDWALGVCN 355

Query: 369 DCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLP--VVKP-SKIGIFLDYELGD 425
           +  +R      +    F  +   +K     +   T+ + P  + KP  ++G+FLD+E G 
Sbjct: 356 NSWIRKNSTMVNSEDIFLLL--CLKVDNHFNLLTTSPVFPHYIEKPLGRVGVFLDFESGS 413

Query: 426 LSFYNMNDRSILYTF-NDCFTEAVWPYFYTG 455
           +SF N+   S+++++     T  V P+FYTG
Sbjct: 414 VSFLNVTKSSLIWSYPAGSLTFPVRPFFYTG 444


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,321,268
Number of Sequences: 37866
Number of extensions: 827137
Number of successful extensions: 3684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 2770
Number of HSP's gapped (non-prelim): 824
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.