Search of human proteins with 22749189

Search of human proteins with 22749189

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22749189 zinc finger protein 645 [Homo sapiens]
         (425 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22749189 zinc finger protein 645 [Homo sapiens]                    909   0.0  
gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming...   450   e-126
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    46   6e-05
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    44   4e-04
gi|151301053 RNA binding motif protein 33 [Homo sapiens]               43   5e-04
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       42   8e-04
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    42   0.001
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             41   0.002
gi|47132519 Ras association and pleckstrin homology domains 1 is...    41   0.002
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          41   0.002
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          41   0.002
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          41   0.002
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    40   0.004
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    40   0.004
gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s...    39   0.007
gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s...    39   0.007
gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]              39   0.007
gi|61966919 hypothetical protein LOC442444 [Homo sapiens]              39   0.007
gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]        39   0.009
gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]        39   0.009
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       39   0.009
gi|110349719 titin isoform N2-A [Homo sapiens]                         39   0.012
gi|239753480 PREDICTED: hypothetical protein [Homo sapiens]            38   0.015
gi|239508790 PREDICTED: hypothetical protein, partial [Homo sapi...    38   0.015
gi|31543543 retinoic acid induced 17 [Homo sapiens]                    38   0.015
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    38   0.015
gi|146134388 YLP motif containing 1 [Homo sapiens]                     38   0.015
gi|23397666 transcriptional co-repressor Sin3A [Homo sapiens]          38   0.020
gi|223941785 transcriptional co-repressor Sin3A [Homo sapiens]         38   0.020
gi|223941782 transcriptional co-repressor Sin3A [Homo sapiens]         38   0.020

>gi|22749189 zinc finger protein 645 [Homo sapiens]
          Length = 425

 Score =  909 bits (2350), Expect = 0.0
 Identities = 425/425 (100%), Positives = 425/425 (100%)

Query: 1   MNKMPAGEQECEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKINIIGEKDDLPIHFCDKC 60
           MNKMPAGEQECEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKINIIGEKDDLPIHFCDKC
Sbjct: 1   MNKMPAGEQECEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKINIIGEKDDLPIHFCDKC 60

Query: 61  DLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMCSIVQQC 120
           DLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMCSIVQQC
Sbjct: 61  DLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMCSIVQQC 120

Query: 121 KRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYI 180
           KRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYI
Sbjct: 121 KRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYI 180

Query: 181 PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV 240
           PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV
Sbjct: 181 PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV 240

Query: 241 DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPP 300
           DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPP
Sbjct: 241 DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPP 300

Query: 301 QDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHY 360
           QDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHY
Sbjct: 301 QDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHY 360

Query: 361 NLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQR 420
           NLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQR
Sbjct: 361 NLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQR 420

Query: 421 RHRRY 425
           RHRRY
Sbjct: 421 RHRRY 425


>gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming
           sequence-like 1 [Homo sapiens]
          Length = 491

 Score =  450 bits (1158), Expect = e-126
 Identities = 229/436 (52%), Positives = 285/436 (65%), Gaps = 13/436 (2%)

Query: 3   KMPAGEQE-CEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKINIIGEKDDLPIHFCDKCD 61
           K P G++E  +YN+E +Y  KG +L   +++ PG+ + D +INI+GEKDD P+HFCDKC 
Sbjct: 54  KAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCG 113

Query: 62  LPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMCSIVQQCK 121
           LPIKIYGR+IPCKH FCY CA L++K G K+CP C  PV RIE   RGS+FMCSIVQ CK
Sbjct: 114 LPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCK 173

Query: 122 RTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIP 181
           RTYLSQ+ LQAHI  RH RA K VT ASLE V P IAPP TEI +      D+ H+S+IP
Sbjct: 174 RTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIP 233

Query: 182 PEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFP--IQWETVSIFTRKHGNLT 239
           P+QH M+  P +QH+  E +NQPH+DI+APP ELS++ P P  +  ET  I TRKH NL 
Sbjct: 234 PKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLI 293

Query: 240 VDHIQNNSDSGAKKPTPP-----DYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNH 294
              IQ++S+SGA++P PP      ++PE Q QP VS PHHI+P +QHYAPPP P  P++H
Sbjct: 294 TVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISH 353

Query: 295 QMPYPPQDVVTPNSVRSQVPALTTT-----YDPSSGYIIVKVPPDMNSPPLRAPQSQNGN 349
            MP+PPQ   TP+ V SQ P    T       P  G+II ++PP MN PP   P  Q+G 
Sbjct: 354 PMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGG 413

Query: 350 PSASEFASHHYNLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPST 409
           P  +    HHYN N LPQFTE+Q TLSP FTQ   M    WPA +   P P  + PP  T
Sbjct: 414 PPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQT 473

Query: 410 LHGRSHHSHQRRHRRY 425
                HH  Q R+R Y
Sbjct: 474 PLPGPHHPDQTRYRPY 489


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 41/168 (24%), Positives = 66/168 (39%), Gaps = 17/168 (10%)

Query: 181 PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV 240
           PP+    ++LP +Q       + P   +  P P+   +L        V +          
Sbjct: 618 PPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL-------AVHLLQAPFSPPPS 670

Query: 241 DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYP- 299
             +Q      A  P  P   P  Q+ P++++P   +P     +PP SPS+    Q P P 
Sbjct: 671 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 730

Query: 300 --PQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQS 345
             P   V P+   S   + + T  P       +VPP + +PPL+ P S
Sbjct: 731 AAPPLQVPPSPPASPPMSPSATPPP-------RVPPLLAAPPLQVPPS 771



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 59/246 (23%), Positives = 85/246 (34%), Gaps = 25/246 (10%)

Query: 123 TYLSQKSLQA---HIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSY 179
           T L   +LQA    +    ++ +  +TS S    RP   PP +     P  L     L  
Sbjct: 416 TSLGSPTLQATHSFLTMSPRQTQASLTSPS----RPASTPPDSPPLQAPLSLPASPPLQT 471

Query: 180 IPPEQHTMVSLPSVQHMLQ-------EQHNQPHKDIQAPPPELSLSLPFP-IQWETVSIF 231
                 + +S P   H LQ            P   +  PP E   SL  P +Q    S+ 
Sbjct: 472 SLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLT 531

Query: 232 TRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSP 291
           T    NL          + A   TP    P C +   + +P   +       PPP   S 
Sbjct: 532 TPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLT-----TPPPETPSS 586

Query: 292 VNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPS 351
           +    P  P  + +P       P L+    P       + PP +  PPL+AP S   +P 
Sbjct: 587 IATPPPQAPPALASPPLQGLPSPPLSPLATPPP-----QAPPXLALPPLQAPPSPPASPP 641

Query: 352 ASEFAS 357
            S  A+
Sbjct: 642 LSPLAT 647



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 49/215 (22%), Positives = 71/215 (33%), Gaps = 25/215 (11%)

Query: 157 IAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELS 216
           +APP  +           ++L  + P      S P     L+         +QAPP  L+
Sbjct: 518 LAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLT 577

Query: 217 LSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHII 276
              P     ET S                        P  P   P  Q+ P ++ P    
Sbjct: 578 TPPP-----ETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQA 632

Query: 277 PQKQHYAPP------PSPSSP---VNHQM-----PYPPQDVVTPNSVRSQVPALTTTYDP 322
           P     +PP      PSP +P     H +     P P   V  P S  +  P   +   P
Sbjct: 633 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 692

Query: 323 SSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFAS 357
           S      + PP + +PPL+ P S   +P  S  A+
Sbjct: 693 S------QAPPSLAAPPLQVPPSPPASPPMSPSAT 721



 Score = 35.4 bits (80), Expect = 0.099
 Identities = 47/213 (22%), Positives = 71/213 (33%), Gaps = 31/213 (14%)

Query: 155 PHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPE 214
           P +A P  ++   P         +  PP    +++ P +Q       + P   +  PPP+
Sbjct: 728 PPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQ 787

Query: 215 LSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHH 274
              +L  P      S      G       Q      A  P  P   P  Q+ P +++P  
Sbjct: 788 APPALATPPLQALPSPPASFPG-------QAPFSPSASLPMSPLATPPPQAPPVLAAPLL 840

Query: 275 IIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPD 334
            +P     +PP SP+     + P P  D           P LT    P         PP 
Sbjct: 841 QVPP----SPPASPTLQAPRRPPTPGPDTSVSG------PRLTLALAPG--------PP- 881

Query: 335 MNSPPLRAPQSQNGNPSASEFASHHYNLNILPQ 367
              PP R+P S    P   + A H  +    P+
Sbjct: 882 --PPPSRSPSSTLSGP---DLAGHSSSATSTPE 909



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 35/116 (30%), Positives = 48/116 (41%), Gaps = 36/116 (31%)

Query: 236 GNLTVDHIQNNSDSGAK-KPTPPDYYPECQSQPAVSSPHHIIPQKQHYAP----PPSPSS 290
           G L+   +   S SG K +P PP   P+  + P    P  + P      P    PPSPS+
Sbjct: 297 GPLSSSPLATPSPSGTKARPVPP---PDNAATPL---PATLPPSPPLATPLPLAPPSPSA 350

Query: 291 PVNHQ-MPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQS 345
           P + Q +P PP    TP S                     + PP M +PP++AP S
Sbjct: 351 PPSLQTLPSPP---ATPPS---------------------QAPPSMTTPPMQAPPS 382



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 53/198 (26%), Positives = 75/198 (37%), Gaps = 39/198 (19%)

Query: 178 SYIPPEQHT--MVSLPSVQHM--LQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTR 233
           S  PP   T  M + PS+Q +  +Q  H+     +QAPP  L+LS               
Sbjct: 366 SQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQA 425

Query: 234 KHGNLTVDHIQNNSD-SGAKKP--TPPDYYP-------------ECQSQPAV---SSPHH 274
            H  LT+   Q  +  +   +P  TPPD  P             +    PAV   SSP  
Sbjct: 426 THSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLT 485

Query: 275 IIP-QKQHYAPPPSPSSPVNHQM--PYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKV 331
           I P Q        SP +P++  +  P   Q  + P S+++   +LTT             
Sbjct: 486 IHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTT------------- 532

Query: 332 PPDMNSPPLRAPQSQNGN 349
           PP  N P L  P  Q  +
Sbjct: 533 PPLENLPSLAPPPLQTAS 550


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 39/151 (25%), Positives = 58/151 (38%), Gaps = 12/151 (7%)

Query: 266 QPAVSSPHHIIPQK--QHYAPPPSPSSPVNHQMPY--PPQDVVTPNSVRSQVPALTTTYD 321
           QP  ++P  I+ Q   Q + P      P++ + P+   P  V+      +Q PA  T   
Sbjct: 681 QPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVA 740

Query: 322 PSSGYIIVKVPPDMNSPPLRAPQS------QNGNPSASEFASHHYNLNILPQFTENQETL 375
             +G  +    PD  + P  APQ       +   PS+S    H   L   P       T 
Sbjct: 741 KGAG--LGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTR 798

Query: 376 SPQFTQTDAMDHRRWPAWKRLSPCPPTRSPP 406
            P    +      R P+   L PCPP ++PP
Sbjct: 799 PPSRPPSRPQSVSRPPSEPPLHPCPPPQAPP 829



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 49/220 (22%), Positives = 78/220 (35%), Gaps = 10/220 (4%)

Query: 125 LSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQ 184
           L+Q SLQ  + +  +R+++ +++       PH++ P + I   P   QD    + +    
Sbjct: 691 LTQDSLQMFLPQ--ERSQQPLSAEG-----PHLSVPASVIVSAPPPAQDPAPATPVAKGA 743

Query: 185 HTMVSLPSVQHMLQEQHNQPHK-DIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHI 243
                 P  Q         P    ++ P P  S SLP              H        
Sbjct: 744 GLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRP 803

Query: 244 QNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDV 303
            +   S ++ P+ P  +P    Q   + P   + Q Q   PPP+ S+P     P PPQ  
Sbjct: 804 PSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPA-SNPAP-TAPGPPQPP 861

Query: 304 VTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAP 343
           + P S   + P     + P S            S  L AP
Sbjct: 862 LRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAP 901


>gi|151301053 RNA binding motif protein 33 [Homo sapiens]
          Length = 1170

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 28/107 (26%), Positives = 38/107 (35%), Gaps = 2/107 (1%)

Query: 242 HIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQ 301
           H Q N       P PP + P+ Q       P H  P +  + PPP    P  H   +PPQ
Sbjct: 573 HTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQ 632

Query: 302 DVVTPNSVRSQV--PALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQ 346
                +     V  P L     P     +    P  +S  ++ PQ Q
Sbjct: 633 HQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQ 679



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/251 (22%), Positives = 85/251 (33%), Gaps = 39/251 (15%)

Query: 156 HIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQ-------HMLQEQHNQPHKDI 208
           H   P       P RL  +D     PP Q        V        H+  EQ + P    
Sbjct: 428 HTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPP---- 483

Query: 209 QAPPPELSLSLPFPIQWETVSIFTR------KHGNLTVDHIQNNSDSGAKKPTPPDYYPE 262
             PPP   L+   P+  ++   FT+      + G   V   +       + P P      
Sbjct: 484 PPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHF 543

Query: 263 CQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMP------YPPQDVVTPNSVRSQVPAL 316
             SQP  ++    IP +Q + P P       H  P      +PP  +  P+  + Q P  
Sbjct: 544 --SQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPP--LPPPHQPQPQQPQQ 599

Query: 317 TTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNI---------LPQ 367
                    +     PP  + PP   PQ    +P   +   HH++L++          PQ
Sbjct: 600 QPPPQHQPPHQPPHQPPPQHQPP---PQHPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQ 656

Query: 368 FTENQETLSPQ 378
           F  + +T  PQ
Sbjct: 657 FRPHVQTAQPQ 667



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 20/61 (32%), Positives = 24/61 (39%)

Query: 155 PHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPE 214
           PH   PQ      P + Q      + PP QH        QH  Q QH+  H  +  PPP 
Sbjct: 589 PHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPP 648

Query: 215 L 215
           L
Sbjct: 649 L 649



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 50/184 (27%), Positives = 59/184 (32%), Gaps = 33/184 (17%)

Query: 254 PTPPDYYPE---CQSQPA-----VSSPHHIIPQKQHYAPPP-------------SPSSPV 292
           P PP   P     Q QP      V  PHH  P +  + PP              +P  P 
Sbjct: 324 PPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPK 383

Query: 293 N-HQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPS 351
           N H  P+    VVTP     QVP L     P        V P     P   PQ   G P 
Sbjct: 384 NIHINPHFKGTVVTP----VQVPLLPVPSQPRPA-----VGPQRFPGPPEFPQHTPG-PV 433

Query: 352 ASEFASHHYNLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLH 411
            + F S    L +  Q+                    R+P+   L    P   PPP TL 
Sbjct: 434 PNSF-SQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLL 492

Query: 412 GRSH 415
             SH
Sbjct: 493 NSSH 496


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 56/244 (22%), Positives = 90/244 (36%), Gaps = 39/244 (15%)

Query: 118 QQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISD-IPKRLQDRDH 176
           QQ +R    Q   Q   +++ ++ ++Q   A     +P +  PQ   S  +P++LQ   H
Sbjct: 236 QQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHH 295

Query: 177 L-------------------SYIPPEQHTMVSLPSVQ----HMLQEQHNQPHKDIQAPPP 213
                               S +PP+  T   +   Q     ML  Q   P K ++AP  
Sbjct: 296 TQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQ--PPLKFVRAPMV 353

Query: 214 ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDS---------GAKKPTPPDYYPECQ 264
                +   +Q +  ++ T +   +    +Q +  S         G +  TP    P  Q
Sbjct: 354 VQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQ 413

Query: 265 SQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRS-QVPA---LTTTY 320
             P    P           P PSPSS +    P P Q  VT  + ++  VP+   L T  
Sbjct: 414 PSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPV 473

Query: 321 DPSS 324
           +PSS
Sbjct: 474 NPSS 477



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 58/243 (23%), Positives = 85/243 (34%), Gaps = 33/243 (13%)

Query: 127 QKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHT 186
           Q+  QA ++++ +  ++Q     L K+       Q +I    ++LQ    L     +Q  
Sbjct: 197 QQQFQAVVQQQQQLQQQQQQQQHLIKLHHQ---NQQQIQQQQQQLQRIAQLQLQQQQQQQ 253

Query: 187 MVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNN 246
                  Q  LQ Q       +Q P P  S +LP  +Q        + H           
Sbjct: 254 QQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQ--------QMHHTQHHQPPPQP 305

Query: 247 SDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSP---SSPVNHQMPYPPQ-- 301
                 +  P    P+ Q+QP VS     +P +  Y  PP     +  V  Q P  PQ  
Sbjct: 306 QQPPVAQNQPSQLPPQSQTQPLVSQA-QALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQ 364

Query: 302 ------------DVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGN 349
                        +V P    SQ  +L     PS G   V+ P  M  PP   P  Q G 
Sbjct: 365 QQQTAVQTAQAAQMVAPGVQVSQ-SSLPMLSSPSPGQ-QVQTPQSMPPPP--QPSPQPGQ 420

Query: 350 PSA 352
           PS+
Sbjct: 421 PSS 423


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 62/269 (23%), Positives = 94/269 (34%), Gaps = 39/269 (14%)

Query: 154  RPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
            +P +  PQ E+   P   Q  +H +     QH +VS P++ + L +Q ++P     A PP
Sbjct: 825  QPILHLPQPELP--PHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPP 882

Query: 214  ELSLS------------LPFPIQWETVSIF-----------TRKHGNLTVDHIQNNSDSG 250
            + +              LP P   +   +            T     L +  +Q      
Sbjct: 883  KPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQK----- 937

Query: 251  AKKPTP--PDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNS 308
             + PTP  P    + Q  P +  P H   Q+Q    PP P  P   Q P   Q    P  
Sbjct: 938  VQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPP-QPQPPPQQQHQPPPRP 996

Query: 309  VRSQVPALTTTYD---PSSGYIIVKVPPDMNSPPLRAPQSQ---NGNPSASEFASHHYNL 362
            V  Q    +T      P  G      PP    PP +  + Q     + S     S  Y+ 
Sbjct: 997  VHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYST 1056

Query: 363  NILPQFTENQETLSPQFTQTDAMDHRRWP 391
              L +        SPQ +Q  ++ H+  P
Sbjct: 1057 GHLREAPSPLMIHSPQMSQFQSLTHQSPP 1085



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 66/276 (23%), Positives = 92/276 (33%), Gaps = 52/276 (18%)

Query: 135 KRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQ 194
           K+ H    +Q+  A     +    PPQ      P + Q +      PP      S+P  Q
Sbjct: 736 KKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQ------PPPPPPPPSMP--Q 787

Query: 195 HMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKP 254
                  + P   I    P L   LP  + ++ +  FT+   +L    +  +     +  
Sbjct: 788 QAAPAMKSSPPPFIATQVPVLEPQLPGSV-FDPIGHFTQPILHLPQPELPPHLPQPPEHS 846

Query: 255 TPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVP 314
           TPP       +Q AV SP  +     H A P  PS P N     PP+    P    +  P
Sbjct: 847 TPPHL-----NQHAVVSPPAL-----HNALPQQPSRPSNRAAALPPKPARPP----AVSP 892

Query: 315 ALTTTYDPSSGYIIVKVPPDMNSPPLRAPQS---QNGNPSASEFASHHYNLNILPQFTEN 371
           ALT T             P +  PP+  P     ++  P A             P  T  
Sbjct: 893 ALTQT-------------PLLPQPPMAQPPQVLLEDEEPPA-------------PPLTSM 926

Query: 372 QETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPP 407
           Q  L  Q  Q         P+ K  S  PP   PPP
Sbjct: 927 QMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPP 962



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 22/74 (29%), Positives = 26/74 (35%), Gaps = 7/74 (9%)

Query: 277 PQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMN 336
           PQ Q   P P P     H  P    D++    V + VP       P        VPP   
Sbjct: 206 PQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPP-------PVPPQPQ 258

Query: 337 SPPLRAPQSQNGNP 350
            PP  APQ    +P
Sbjct: 259 PPPAPAPQPVQSHP 272



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 42/180 (23%), Positives = 62/180 (34%), Gaps = 33/180 (18%)

Query: 232 TRKHGNLTVDHIQNNS---DSGAKKPTPPDYYPECQSQPAVSSP-------HHIIPQKQH 281
           T K G  TV +    S    +   +P PP         PAV+           ++P +  
Sbjct: 188 TAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPL 247

Query: 282 YAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSP--- 338
             PPP P  P        P     P  V+S  P +  T  P      VK   D  +P   
Sbjct: 248 QTPPPVPPQP-------QPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI 300

Query: 339 -PLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLS 397
            P+  P S    P  ++          L Q  E+   + P   + D  D ++ PA ++ S
Sbjct: 301 DPIHEPPSLPPEPKTTK----------LGQRRESSRPVKP--PKKDVPDSQQHPAPEKSS 348


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 41/168 (24%), Positives = 59/168 (35%), Gaps = 11/168 (6%)

Query: 249  SGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAP------PPSPSSPVNHQMPYPPQD 302
            S +  PT P Y P   S    S  +   P   +Y+P      P SPS         P   
Sbjct: 1717 SPSYSPTSPSYSPTSPSYSPTSPSYS--PTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSP 1774

Query: 303  VVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNL 362
              TP S        + +Y P+S       P    S P   PQS    PS+  ++    + 
Sbjct: 1775 NYTPTS--PNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSY 1832

Query: 363  N-ILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPST 409
            +   P++T    + SP   +      +  P   + SP  P  SP   T
Sbjct: 1833 SPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPT 1880



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 11/152 (7%)

Query: 254  PTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQV 313
            PT P Y P   S  + +SP++  P   +Y+P     SP +     P     +P+S R   
Sbjct: 1757 PTSPSYSPTSPSY-SPTSPNYT-PTSPNYSPTSPSYSPTSPSYS-PTSPSYSPSSPR--Y 1811

Query: 314  PALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQE 373
               + TY PSS       P    + P   P S + +PS+ E+          P+++    
Sbjct: 1812 TPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTP------TSPKYSPTSP 1865

Query: 374  TLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSP 405
              SP   +         P   + SP  PT SP
Sbjct: 1866 KYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSP 1897



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 39/163 (23%), Positives = 57/163 (34%), Gaps = 22/163 (13%)

Query: 249  SGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPP---SPSSPVNHQMPYPPQDVVT 305
            S +  PT P Y P         SP    PQ   Y+P     SP+SP     P  P    T
Sbjct: 1590 SPSYSPTSPAYEPR--------SPGGYTPQSPSYSPTSPSYSPTSP--SYSPTSPNYSPT 1639

Query: 306  PNSVRSQVPALTTT---YDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNL 362
              S     P+ + T   Y P+S       P    + P  +P S + +P++  ++      
Sbjct: 1640 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP----- 1694

Query: 363  NILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSP 405
               P ++    + SP             P     SP  P+ SP
Sbjct: 1695 -TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP 1736


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 44/219 (20%)

Query: 211 PPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSD-SGA--KKPTPPDYYPECQSQP 267
           PPP    S   P       +F +     T+  +QN S  SGA  K PTPP    +     
Sbjct: 644 PPPPPLPSQSAPSAGSAAPMFVKYS---TITRLQNASQHSGALFKPPTPPVMQSQSVKPQ 700

Query: 268 AVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYP-----PQDVVTPNSVR-SQVPALTTTYD 321
            +  P+ ++P      PPP+P S +    P P     PQ    P  ++  QV  +T    
Sbjct: 701 ILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAP 760

Query: 322 PSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSPQFTQ 381
           P+        PP    PP+ AP      P           L  +P  T + +T++P  TQ
Sbjct: 761 PTP-------PP---PPPIPAPLPPQAPPKP---------LVTIPAPT-STKTVAPVVTQ 800

Query: 382 T-------DAMDHRRWPAWKR-----LSPCPPTRSPPPS 408
                        ++ PA+         P PP   PPP+
Sbjct: 801 AAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPT 839



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 47/176 (26%), Positives = 70/176 (39%), Gaps = 32/176 (18%)

Query: 188 VSLPSVQHMLQ--EQHNQPHKDIQAP-----PPELSLSLPFPIQWETVS-IFTRKHGNLT 239
           + +  VQH+ Q       P   I AP     PP+  +++P P   +TV+ + T+      
Sbjct: 747 LKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTP 806

Query: 240 VDHIQNNSDSGAKKPT-PPDYYPECQSQPAVSSPHHIIPQKQHYA--PPPSPSSPV---- 292
              +        K+P  P  Y P     P V  P   +P++Q +   PPPSP SPV    
Sbjct: 807 TPPVP----PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVV 862

Query: 293 ---NHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQS 345
                Q P PP    TP ++ SQ         P    +  + PP + + P   P S
Sbjct: 863 KQIASQFPPPP----TPPAMESQ------PLKPVPANVAPQSPPAVKAKPKWQPSS 908



 Score = 32.3 bits (72), Expect = 0.84
 Identities = 61/235 (25%), Positives = 82/235 (34%), Gaps = 38/235 (16%)

Query: 158  APPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSL 217
            APP       P + Q     SYIPP   T   +P     L +Q +       A PP   L
Sbjct: 802  APPTPTPPVPPAKKQPAFPASYIPPSPPTP-PVPVPPPTLPKQQS-----FCAKPPPSPL 855

Query: 218  SLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSS-----P 272
            S P P      S+  +              +S   KP P +  P  QS PAV +     P
Sbjct: 856  S-PVP------SVVKQIASQFPPPPTPPAMESQPLKPVPANVAP--QSPPAVKAKPKWQP 906

Query: 273  HHII----------PQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDP 322
              I           P+     PPP P SPV    P PP    +P   +S  P   T+   
Sbjct: 907  SSIPVPSPDFPPPPPESSLVFPPP-PPSPVPAPPP-PPPPTASPTPDKSGSPGKKTSKTS 964

Query: 323  SSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSP 377
            S G       P  NS    +  +++  P      S      ++ +FT   E+ SP
Sbjct: 965  SPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDS------LVSKFTPPAESGSP 1013


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 74/302 (24%), Positives = 100/302 (33%), Gaps = 62/302 (20%)

Query: 156 HIAPPQTEISDIPKRLQDRDHLSYIPPEQ--HTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
           H  PPQ      P+  Q +  L   P     HT + LP+ Q  LQ Q  QP ++   PP 
Sbjct: 311 HPGPPQP-FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQ--QPPREQPLPPA 367

Query: 214 ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNS--DSGAKKPTPPDYYPEC-------- 263
            L++    P     +        +    H+   S     A  P PP   P          
Sbjct: 368 PLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPP 427

Query: 264 -----------QSQPAVSSPHHI--IPQKQHYAPPPSPSSPVN-HQM-PYPP---QDVVT 305
                      QSQP  SSP     + Q Q+  PPP+   P   HQ+ P PP      V 
Sbjct: 428 SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVP 487

Query: 306 PNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNIL 365
                   P   +T  P +G      P     PP     +  G+ +             L
Sbjct: 488 GGPPPITPPTCPSTSTPPAG------PGTSAQPPCSGAAASGGSIAGGSSCP-------L 534

Query: 366 PQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTR--SPPPSTLHGRSHHSHQRRHR 423
           P     +E          A+D    P     SP PP R  SP P+ +   SH S   R  
Sbjct: 535 PTVQIKEE----------ALDDAEEPE----SPPPPPRSPSPEPTVVDTPSHASQSARFY 580

Query: 424 RY 425
           ++
Sbjct: 581 KH 582


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 74/302 (24%), Positives = 100/302 (33%), Gaps = 62/302 (20%)

Query: 156  HIAPPQTEISDIPKRLQDRDHLSYIPPEQ--HTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
            H  PPQ      P+  Q +  L   P     HT + LP+ Q  LQ Q  QP ++   PP 
Sbjct: 865  HPGPPQP-FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQ--QPPREQPLPPA 921

Query: 214  ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNS--DSGAKKPTPPDYYPEC-------- 263
             L++    P     +        +    H+   S     A  P PP   P          
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPP 981

Query: 264  -----------QSQPAVSSPHHI--IPQKQHYAPPPSPSSPVN-HQM-PYPP---QDVVT 305
                       QSQP  SSP     + Q Q+  PPP+   P   HQ+ P PP      V 
Sbjct: 982  SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVP 1041

Query: 306  PNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNIL 365
                    P   +T  P +G      P     PP     +  G+ +             L
Sbjct: 1042 GGPPPITPPTCPSTSTPPAG------PGTSAQPPCSGAAASGGSIAGGSSCP-------L 1088

Query: 366  PQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTR--SPPPSTLHGRSHHSHQRRHR 423
            P     +E          A+D    P     SP PP R  SP P+ +   SH S   R  
Sbjct: 1089 PTVQIKEE----------ALDDAEEPE----SPPPPPRSPSPEPTVVDTPSHASQSARFY 1134

Query: 424  RY 425
            ++
Sbjct: 1135 KH 1136


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 74/302 (24%), Positives = 100/302 (33%), Gaps = 62/302 (20%)

Query: 156  HIAPPQTEISDIPKRLQDRDHLSYIPPEQ--HTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
            H  PPQ      P+  Q +  L   P     HT + LP+ Q  LQ Q  QP ++   PP 
Sbjct: 865  HPGPPQP-FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQ--QPPREQPLPPA 921

Query: 214  ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNS--DSGAKKPTPPDYYPEC-------- 263
             L++    P     +        +    H+   S     A  P PP   P          
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPP 981

Query: 264  -----------QSQPAVSSPHHI--IPQKQHYAPPPSPSSPVN-HQM-PYPP---QDVVT 305
                       QSQP  SSP     + Q Q+  PPP+   P   HQ+ P PP      V 
Sbjct: 982  SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVP 1041

Query: 306  PNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNIL 365
                    P   +T  P +G      P     PP     +  G+ +             L
Sbjct: 1042 GGPPPITPPTCPSTSTPPAG------PGTSAQPPCSGAAASGGSIAGGSSCP-------L 1088

Query: 366  PQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTR--SPPPSTLHGRSHHSHQRRHR 423
            P     +E          A+D    P     SP PP R  SP P+ +   SH S   R  
Sbjct: 1089 PTVQIKEE----------ALDDAEEPE----SPPPPPRSPSPEPTVVDTPSHASQSARFY 1134

Query: 424  RY 425
            ++
Sbjct: 1135 KH 1136


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 40/175 (22%), Positives = 61/175 (34%), Gaps = 20/175 (11%)

Query: 181 PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV 240
           PP+    ++LP +Q       + P   +  P P+   +L        V +          
Sbjct: 393 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL-------AVHLLQAPFSPPPS 445

Query: 241 DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPP 300
             +Q      A  P  P   P  Q+ P++++P   +P     +PP SPS+    Q P P 
Sbjct: 446 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP- 504

Query: 301 QDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPP--DMNSPPLRAPQSQNGNPSAS 353
                        P L     P      +  PP   + SPP   P     +PSAS
Sbjct: 505 ----------LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 549



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 51/202 (25%), Positives = 78/202 (38%), Gaps = 46/202 (22%)

Query: 157 IAPPQTEISDIPKRLQDRDHLSYIPPEQHTM-VSLPSVQHMLQEQHNQPHKDIQAPPPEL 215
           +APP       P  LQ        PP Q T  +  P++Q       + P   +  PPP+ 
Sbjct: 340 LAPPSPSA---PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396

Query: 216 SLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHI 275
             +L  P                    +Q      A  P  P   P  Q+  A++   H+
Sbjct: 397 PPALALP-------------------PLQAPPSPPASPPLSPLATPSPQAPNALAV--HL 435

Query: 276 IPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDM 335
           +  +  ++PPPSP  PV  Q P+ P     P S     P ++ +  P S     + PP +
Sbjct: 436 L--QAPFSPPPSP--PV--QAPFSP-----PAS-----PPVSPSATPPS-----QAPPSL 474

Query: 336 NSPPLRAPQSQNGNPSASEFAS 357
            +PPL+ P S   +P  S  A+
Sbjct: 475 AAPPLQVPPSPPASPPMSPSAT 496


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 40/175 (22%), Positives = 61/175 (34%), Gaps = 20/175 (11%)

Query: 181 PPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTV 240
           PP+    ++LP +Q       + P   +  P P+   +L        V +          
Sbjct: 354 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL-------AVHLLQAPFSPPPS 406

Query: 241 DHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPP 300
             +Q      A  P  P   P  Q+ P++++P   +P     +PP SPS+    Q P P 
Sbjct: 407 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP- 465

Query: 301 QDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPP--DMNSPPLRAPQSQNGNPSAS 353
                        P L     P      +  PP   + SPP   P     +PSAS
Sbjct: 466 ----------LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 510



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 51/201 (25%), Positives = 77/201 (38%), Gaps = 46/201 (22%)

Query: 158 APPQTEISDIPKRLQDRDHLSYIPPEQHTM-VSLPSVQHMLQEQHNQPHKDIQAPPPELS 216
           APP       P  LQ        PP Q T  +  P++Q       + P   +  PPP+  
Sbjct: 302 APPSPSA---PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 358

Query: 217 LSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHII 276
            +L  P                    +Q      A  P  P   P  Q+  A++   H++
Sbjct: 359 PALALP-------------------PLQAPPSPPASPPLSPLATPSPQAPNALAV--HLL 397

Query: 277 PQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMN 336
             +  ++PPPSP  PV  Q P+ P     P S     P ++ +  P S     + PP + 
Sbjct: 398 --QAPFSPPPSP--PV--QAPFSP-----PAS-----PPVSPSATPPS-----QAPPSLA 436

Query: 337 SPPLRAPQSQNGNPSASEFAS 357
           +PPL+ P S   +P  S  A+
Sbjct: 437 APPLQVPPSPPASPPMSPSAT 457



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 18/114 (15%)

Query: 252 KKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQ-MPYPPQDVVTPNSVR 310
           +K   P   P   S  A  SP          + PPSPS+P + Q +P PP    +  +  
Sbjct: 280 RKDAAPALGPLSSSPLATPSP----------SAPPSPSAPPSLQTLPSPPATPPSQATTS 329

Query: 311 SQVPALTTTYD--PSSGYIIV-----KVPPDMNSPPLRAPQSQNGNPSASEFAS 357
              P L  T+   PS     +     + PP +  PPL+AP S   +P  S  A+
Sbjct: 330 LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT 383


>gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
            sapiens]
          Length = 1858

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 78/320 (24%), Positives = 120/320 (37%), Gaps = 54/320 (16%)

Query: 135  KRRHKRARKQVTSAS---LEKVRPHIAPPQTEISDIPKRLQDR----DHLSYIP-PEQHT 186
            ++R + ARK  +      L  V PH +   +   D      D     DH + +P P   T
Sbjct: 1163 RKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPAT 1222

Query: 187  MVSLPSVQHMLQEQHNQPHKDIQAPP---PELSLSLPFPIQWETVSIFTRKHGNLTVDHI 243
            + +  S +      +N P KD  A     PE+  +    +  E V   + +   L  DH 
Sbjct: 1223 VYNATSEE----TSNNCPVKDATASEKNEPEVQWTASTSV--EQVRERSYQRALLLSDH- 1275

Query: 244  QNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDV 303
            + + DSG + P         QS P+  S H  IPQ Q   P PS S  +    P  P+  
Sbjct: 1276 RKDKDSGGESPCVSCSPSHVQSSPSSHSNH--IPQLQAKGPVPSFSELMEDPDPENPEPT 1333

Query: 304  VT---PNSVRSQ-----VPALTTTYDPSS-------GYIIVKVPPDMNSPPLRAPQSQNG 348
             T   P+   SQ      P ++    P S       G I  K  P  +S  + A +++NG
Sbjct: 1334 TTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDS-TVSASEAENG 1392

Query: 349  NPSASEFASHHYNLNILPQFTENQETLS----PQFTQTDAMDH--RRWPAWKRLSPCPPT 402
                +E            Q + N + LS    PQ    ++ +   ++ P+      CPP+
Sbjct: 1393 VHLKTELQQ--------KQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPS 1444

Query: 403  ----RSPPPSTLHGRSHHSH 418
                  P  ST H    H +
Sbjct: 1445 PHLENPPKSSTPHTPVQHGY 1464



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 36/143 (25%), Positives = 48/143 (33%), Gaps = 35/143 (24%)

Query: 237  NLTVDHIQNNSDSGAKKPTPPDYYPECQSQP----------------AVSSPHHIIPQK- 279
            N T+ H    +      P PP   P    QP                AV+   HI  Q  
Sbjct: 1614 NPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTA 1673

Query: 280  -QHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSP 338
              H  PPP P  P  H  P PP        +++Q             +++   PP    P
Sbjct: 1674 GHHLPPPPPPPGPAPHHHP-PPHPSTGLQGLQAQ-----------HQHVVNSAPPPPPPP 1721

Query: 339  PLRAPQS--QNGNPSASEFASHH 359
            P   P S   +G+ + S  A HH
Sbjct: 1722 P---PSSVLASGHHTTSAQALHH 1741


>gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
            sapiens]
          Length = 1858

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 78/320 (24%), Positives = 120/320 (37%), Gaps = 54/320 (16%)

Query: 135  KRRHKRARKQVTSAS---LEKVRPHIAPPQTEISDIPKRLQDR----DHLSYIP-PEQHT 186
            ++R + ARK  +      L  V PH +   +   D      D     DH + +P P   T
Sbjct: 1163 RKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPAT 1222

Query: 187  MVSLPSVQHMLQEQHNQPHKDIQAPP---PELSLSLPFPIQWETVSIFTRKHGNLTVDHI 243
            + +  S +      +N P KD  A     PE+  +    +  E V   + +   L  DH 
Sbjct: 1223 VYNATSEE----TSNNCPVKDATASEKNEPEVQWTASTSV--EQVRERSYQRALLLSDH- 1275

Query: 244  QNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDV 303
            + + DSG + P         QS P+  S H  IPQ Q   P PS S  +    P  P+  
Sbjct: 1276 RKDKDSGGESPCVSCSPSHVQSSPSSHSNH--IPQLQAKGPVPSFSELMEDPDPENPEPT 1333

Query: 304  VT---PNSVRSQ-----VPALTTTYDPSS-------GYIIVKVPPDMNSPPLRAPQSQNG 348
             T   P+   SQ      P ++    P S       G I  K  P  +S  + A +++NG
Sbjct: 1334 TTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDS-TVSASEAENG 1392

Query: 349  NPSASEFASHHYNLNILPQFTENQETLS----PQFTQTDAMDH--RRWPAWKRLSPCPPT 402
                +E            Q + N + LS    PQ    ++ +   ++ P+      CPP+
Sbjct: 1393 VHLKTELQQ--------KQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPS 1444

Query: 403  ----RSPPPSTLHGRSHHSH 418
                  P  ST H    H +
Sbjct: 1445 PHLENPPKSSTPHTPVQHGY 1464



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 36/143 (25%), Positives = 48/143 (33%), Gaps = 35/143 (24%)

Query: 237  NLTVDHIQNNSDSGAKKPTPPDYYPECQSQP----------------AVSSPHHIIPQK- 279
            N T+ H    +      P PP   P    QP                AV+   HI  Q  
Sbjct: 1614 NPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTA 1673

Query: 280  -QHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSP 338
              H  PPP P  P  H  P PP        +++Q             +++   PP    P
Sbjct: 1674 GHHLPPPPPPPGPAPHHHP-PPHPSTGLQGLQAQ-----------HQHVVNSAPPPPPPP 1721

Query: 339  PLRAPQS--QNGNPSASEFASHH 359
            P   P S   +G+ + S  A HH
Sbjct: 1722 P---PSSVLASGHHTTSAQALHH 1741


>gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]
          Length = 2063

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 34/110 (30%), Positives = 42/110 (38%), Gaps = 15/110 (13%)

Query: 245  NNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQK--QHYAPPPSPSS-------PVNHQ 295
            N  +SG K P   +  P   SQP    P   +P +  QH APPP P         P   Q
Sbjct: 955  NLDNSGPKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQ 1014

Query: 296  MPYP--PQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAP 343
             P P  PQ        +  +  L    DP S    V++P   N  P R P
Sbjct: 1015 PPPPSQPQSQQQQQQQQQMMMMLMMQQDPKS----VRLPVSQNVHPPRGP 1060


>gi|61966919 hypothetical protein LOC442444 [Homo sapiens]
          Length = 1035

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 50/225 (22%), Positives = 86/225 (38%), Gaps = 28/225 (12%)

Query: 94  PRCRYPVLRIEAHKRGSVFMCSIVQQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKV 153
           P+ R   LR E  K G   +C    + + ++L  +  +  +   H R     T  S    
Sbjct: 407 PKTRISNLRSEPPKIGVSHLCLEPPKTRGSHLRPEPPETGVS--HLRPEPPKTRVS---- 460

Query: 154 RPHIAPPQTEISDIPKRLQDRD--HLSYIPPEQHTMVSLPS-----VQHMLQEQHNQPHK 206
             H+ PP+T +S +     ++D  HL   PP+       P      V H+  E       
Sbjct: 461 SLHLEPPETGVSHLCPEPPEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVS 520

Query: 207 DIQAPPPELSLSLPFPIQWET-VSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYP-ECQ 264
            ++  PP++ +S       E+ VS    +     V H+         +P PP       +
Sbjct: 521 HLRPEPPKILVSSLHQAPPESSVSHLRPEPPETGVSHL---------RPEPPKTRMYSLR 571

Query: 265 SQPAVSSPHHIIPQ----KQHYAPPPSPSSPVNHQMPYPPQDVVT 305
            +P  +   H+ P+    +    PP  P + V+H  P PP+  V+
Sbjct: 572 PEPPDTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVS 616



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 61/247 (24%), Positives = 99/247 (40%), Gaps = 32/247 (12%)

Query: 159 PPQTEISDIPKRLQDR--DHLSYIPPEQHTMVSLPS-----VQHMLQEQHNQPHKDIQAP 211
           PP+T +S +P    +    HL   PPE       P      V H+  E        ++  
Sbjct: 586 PPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRPE 645

Query: 212 PPELSLSLPFPIQWET-VSIFTRKHGNLTVDHI---QNNSDSGAKKPTPPD-----YYPE 262
           PP   +S   P   +T VS    +     V H+      +     +P PP+      +PE
Sbjct: 646 PPNTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPE 705

Query: 263 CQSQPAVSSPHHIIPQKQ--HYAPPPSPSSPVNHQMPYPPQDVVT---PNSVRSQVPALT 317
              +  VSS H   P+ +  H  P P P + V+H  P PP+  V+   P  + ++V  L 
Sbjct: 706 -PPKTRVSSLHAEPPESRVSHLCPEP-PETGVSHLRPEPPKPRVSSLRPEPLETRVSHLR 763

Query: 318 TTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSP 377
               P +G  +  + P++  P +    S +  P  +   S   +L + P  T    +L P
Sbjct: 764 PE-PPETG--VSHLHPELPKPRV---SSLHLEPPKTRRVS---SLRLEPPKTGRVSSLCP 814

Query: 378 QFTQTDA 384
           + T+T A
Sbjct: 815 EPTKTGA 821



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 51/203 (25%), Positives = 71/203 (34%), Gaps = 49/203 (24%)

Query: 156 HIAPPQTEISDI----PKRLQDRDHLSYIPPE---QHTMVSLPS--VQHMLQEQHNQPHK 206
           H+ PP+T +S +    PK      HL   PPE    H  +  P   V H+  E       
Sbjct: 235 HLEPPETGVSHLRPEPPKTQVSSLHLE--PPETGVSHLYLEPPGTGVSHLCPEPPKTRVS 292

Query: 207 DIQAPPPELSL-SLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQS 265
            +   PPE  +  L        VS    +     V H+          P PP        
Sbjct: 293 HLHREPPETGVPDLCLEPPKSRVSHLRPEPSETGVSHLH---------PEPP-------- 335

Query: 266 QPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSG 325
           +  VSS H           P  P + V+H  P PP+  V+P  +R   P    ++     
Sbjct: 336 KTLVSSLH-----------PEPPETGVSHLCPEPPETRVSP--LRQLPPEAGVSH----- 377

Query: 326 YIIVKVPPDMNSPPLRAPQSQNG 348
             +   PP    PPLR    +NG
Sbjct: 378 --LCPEPPKTRVPPLRPETPKNG 398



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 51/243 (20%), Positives = 86/243 (35%), Gaps = 40/243 (16%)

Query: 94  PRCRYPVLRIEAHKRGSVFMCSIVQQCKRTYLSQKSLQAHI--------KRRHKRARKQV 145
           P+ R   L +E  + G   +C    +   ++L  +     +        K R    R + 
Sbjct: 455 PKTRVSSLHLEPPETGVSHLCPEPPEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEP 514

Query: 146 TSASLEKVRP----------HIAPPQTEISDIPKRLQDR--DHLSYIPPEQHTMVSLPS- 192
           +   +  +RP          H APP++ +S +     +    HL   PP+       P  
Sbjct: 515 SETGVSHLRPEPPKILVSSLHQAPPESSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEP 574

Query: 193 ----VQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWET-VSIFTRKHGNLTVDHIQNNS 247
               V H+  E        +   PPE  +S   P   ET VS    +     V H+    
Sbjct: 575 PDTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHL---- 630

Query: 248 DSGAKKPTPPDYYP-ECQSQPAVSSPHHIIPQ----KQHYAPPPSPSSPVNHQMPYPPQD 302
                +P PP       + +P  +   H+ P+    +    PP  P + V+H  P PP+ 
Sbjct: 631 -----RPEPPKTRMYSLRPEPPNTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPET 685

Query: 303 VVT 305
            V+
Sbjct: 686 RVS 688


>gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]
          Length = 1337

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 49/191 (25%), Positives = 63/191 (32%), Gaps = 21/191 (10%)

Query: 245 NNSDSGAKKPTPPDYYP-ECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDV 303
           +NS +    P  PD+ P      P+   P    P +     PP P+  + H  P PP   
Sbjct: 64  SNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIR-----PPFPNHQMRHPFPVPPCFP 118

Query: 304 VTPNSVRSQVPALTTTYDPSSG-YIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNL 362
             P  +            P  G +  +  PP M  PP      Q  N       SHH   
Sbjct: 119 PMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHH--- 175

Query: 363 NILP----QFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSH--- 415
           N  P     F  N  +  P    + +   R  P +  L   P  R  P    H   H   
Sbjct: 176 NFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYP-LPKAPSERRSPERLKHYDDHRHR 234

Query: 416 -HSHQR--RHR 423
            HSH R  RHR
Sbjct: 235 DHSHGRGERHR 245



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 46/175 (26%), Positives = 60/175 (34%), Gaps = 39/175 (22%)

Query: 254 PTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNH---QMPYPPQDVVTPNSVR 310
           P PP + P     P  ++P   +P     APP   + P       MP+PP   V P  V 
Sbjct: 112 PVPPCFPPMPPPMPCPNNPP--VPG----APPGQGTFPFMMPPPSMPHPPPPPVMPQQVN 165

Query: 311 SQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGN--PSASEFASHHYNLNILPQF 368
            Q P          GY     PP    P   + Q+   +  PSA+  +S H+        
Sbjct: 166 YQYP---------PGYSHHNFPP----PSFNSFQNNPSSFLPSANNSSSPHFR------- 205

Query: 369 TENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQRRHR 423
                   P +    A   RR P  +RL      R    S   G  H S  RR R
Sbjct: 206 ------HLPPYPLPKAPSERRSP--ERLKHYDDHRHRDHSHGRGERHRSLDRRER 252


>gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]
          Length = 1374

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 49/191 (25%), Positives = 63/191 (32%), Gaps = 21/191 (10%)

Query: 245 NNSDSGAKKPTPPDYYP-ECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDV 303
           +NS +    P  PD+ P      P+   P    P +     PP P+  + H  P PP   
Sbjct: 64  SNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIR-----PPFPNHQMRHPFPVPPCFP 118

Query: 304 VTPNSVRSQVPALTTTYDPSSG-YIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNL 362
             P  +            P  G +  +  PP M  PP      Q  N       SHH   
Sbjct: 119 PMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHH--- 175

Query: 363 NILP----QFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSH--- 415
           N  P     F  N  +  P    + +   R  P +  L   P  R  P    H   H   
Sbjct: 176 NFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYP-LPKAPSERRSPERLKHYDDHRHR 234

Query: 416 -HSHQR--RHR 423
            HSH R  RHR
Sbjct: 235 DHSHGRGERHR 245



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 46/175 (26%), Positives = 60/175 (34%), Gaps = 39/175 (22%)

Query: 254 PTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNH---QMPYPPQDVVTPNSVR 310
           P PP + P     P  ++P   +P     APP   + P       MP+PP   V P  V 
Sbjct: 112 PVPPCFPPMPPPMPCPNNPP--VPG----APPGQGTFPFMMPPPSMPHPPPPPVMPQQVN 165

Query: 311 SQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGN--PSASEFASHHYNLNILPQF 368
            Q P          GY     PP    P   + Q+   +  PSA+  +S H+        
Sbjct: 166 YQYP---------PGYSHHNFPP----PSFNSFQNNPSSFLPSANNSSSPHFR------- 205

Query: 369 TENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQRRHR 423
                   P +    A   RR P  +RL      R    S   G  H S  RR R
Sbjct: 206 ------HLPPYPLPKAPSERRSP--ERLKHYDDHRHRDHSHGRGERHRSLDRRER 252


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 56/240 (23%), Positives = 81/240 (33%), Gaps = 36/240 (15%)

Query: 157  IAPPQTEISDI---PKRLQDRDHLSY--IPPEQH--TMVSLPSVQHMLQEQHNQ-PHKDI 208
            + PP T ++ I   P  L D    +   +PP Q+    V LPS+   L       P + +
Sbjct: 800  VVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAV 859

Query: 209  QAP-PPELSLSLP----FPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPEC 263
            + P PP   L++P     P    T+ +       +    I +       +P  P  +P+ 
Sbjct: 860  KLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQM 919

Query: 264  QSQPAVSSPHHIIPQKQHYAP----PPSPSSPVNHQMP----YPPQDVVTPNSVRSQVPA 315
                   SPHH +   +   P    PP P+ P    +P     PPQ V+ P   R   P 
Sbjct: 920  APTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPV 979

Query: 316  LTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETL 375
            L               PP    PP      Q   P   E    H      P  T   + L
Sbjct: 980  L---------------PPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQIL 1024



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 22/68 (32%), Positives = 29/68 (42%), Gaps = 5/68 (7%)

Query: 284 PPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAP 343
           PPPS   P     P PP     P +  + +P +     P     +  VPP +  PP  AP
Sbjct: 711 PPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLA---PQPVVPLQPVPPHL--PPYLAP 765

Query: 344 QSQNGNPS 351
            SQ G P+
Sbjct: 766 ASQVGAPA 773


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 42/206 (20%), Positives = 79/206 (38%), Gaps = 19/206 (9%)

Query: 152   KVRPHIAPPQTEISDIPKRLQDRDHLSY-----IPPEQHTMVSLPSVQHMLQEQHNQPHK 206
             KV P   PP  ++ ++PK++   + +       +PP +   V  P      ++    P K
Sbjct: 10458 KVVPRKEPP-AKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAK 10516

Query: 207   DIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQ 266
               +APPP++  +    +  + V +   K   +    +     +   +   P+  P     
Sbjct: 10517 KPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPES 10576

Query: 267   P---AVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSV---RSQVPALTTTY 320
             P      +P  ++P+K+  A PP        ++P  P++VV    V     + P +  T 
Sbjct: 10577 PPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTK 10636

Query: 321   DPSSGYIIV-------KVPPDMNSPP 339
              P    + V        +PP   SPP
Sbjct: 10637 VPEVPKVAVPEKKVPEAIPPKPESPP 10662



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 23/95 (24%), Positives = 37/95 (38%), Gaps = 2/95 (2%)

Query: 252   KKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRS 311
             K P PP   PE        +P  ++P+K+   PPP        ++P  P+  V    V  
Sbjct: 10509 KVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPE 10568

Query: 312   QVPALTTTYDPSSGYIIVKVPPDMNSP--PLRAPQ 344
              +P    +  P       +V P+   P  P + P+
Sbjct: 10569 AIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPE 10603



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 52/236 (22%), Positives = 80/236 (33%), Gaps = 50/236 (21%)

Query: 139  KRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQ 198
            K A ++V    + K    + PP  ++ ++PK+           PE+   V +P       
Sbjct: 9294 KPAPEEVAPVPIPK---KVEPPAPKVPEVPKKPV---------PEEKKPVPVP------- 9334

Query: 199  EQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPD 258
                   K   A PP++      P+  E + +   K                 KK  PP 
Sbjct: 9335 -------KKEPAAPPKVPEVPKKPVPEEKIPVPVAK-----------------KKEAPPA 9370

Query: 259  YYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSP----VNHQMPYPPQDVVTPNSVRSQVP 314
              PE Q          I+ Q++   PP  P  P       + P P ++   P     +VP
Sbjct: 9371 KVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPP--PKVP 9428

Query: 315  ALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTE 370
            AL     P    + V VP    +PP RA  S+        F +       +PQ  E
Sbjct: 9429 ALPKKPVPEE-KVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVE 9483



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 37/161 (22%), Positives = 61/161 (37%), Gaps = 17/161 (10%)

Query: 251  AKKPTPPDYYPECQSQPAVSSPHHI-IPQKQHYAPPPSPSSPVNHQMPYPPQDVVTP--- 306
            +K+  PP   PE   +PA      + IP+K     PP+P  P   + P P +    P   
Sbjct: 9279 SKRVEPPPKVPELPEKPAPEEVAPVPIPKK---VEPPAPKVPEVPKKPVPEEKKPVPVPK 9335

Query: 307  --NSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNI 364
               +   +VP +     P    I V V     +PP + P+ Q G  +  +       + I
Sbjct: 9336 KEPAAPPKVPEVPKKPVPEE-KIPVPVAKKKEAPPAKVPEVQKGVVTEEK-------ITI 9387

Query: 365  LPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSP 405
            + Q  E+     P+  +    + R+    K     PP + P
Sbjct: 9388 VTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVP 9428



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 51/222 (22%), Positives = 76/222 (34%), Gaps = 44/222 (19%)

Query: 141   ARKQVTSASLEKVRPHIAP--PQTEISDIPKR-LQDRDHLSYIPPEQHTMVSLPSVQHML 197
             A K+V       V P   P  P T++ ++PK  + ++     IPP+  +    P V    
Sbjct: 10528 APKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPP--PEVPEAP 10585

Query: 198   QEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPP 257
             +E    P K + A PP+     P  +      +   K                 K P PP
Sbjct: 10586 KEV--VPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEK-----------------KVPVPP 10626

Query: 258   DYYPECQSQ-----PAVSSPH----HIIPQKQHYAPPPSPSSPVNHQMPYPPQDVV---- 304
                PE         P V+ P       IP K    PP     P    +  PP +VV    
Sbjct: 10627 PKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPE 10686

Query: 305   --TPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQ 344
                P  V   VP      +  +  ++ K P     PP++ P+
Sbjct: 10687 PAAPPQV--TVPPKKPVPEKKAPAVVAKKP---ELPPVKVPE 10723



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 45/236 (19%), Positives = 89/236 (37%), Gaps = 37/236 (15%)

Query: 140   RARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQE 199
             + ++ V    +   R  +APP   + ++PK L+  +    +  E+  +  +   +++++E
Sbjct: 9873  KPKRVVAEEKVPVPRKEVAPP-VRVPEVPKELEPEE----VAFEEEVVTHVE--EYLVEE 9925

Query: 200   QHNQPHKD------------IQAPPPELSLSLPFPIQWETVSIFTRKHGN-LTVDHIQNN 246
             +    H++            I    PE+    P P + + V +  +K      V  +   
Sbjct: 9926  EEEYIHEEEEFITEEEVVPVIPVKVPEVPRK-PVPEEKKPVPVPKKKEAPPAKVPEVPKK 9984

Query: 247   SDSGA------KKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPS----PSSPV-NHQ 295
              +         K+  PP   PE   +P       +   K+  APP      P  PV   +
Sbjct: 9985  PEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKK 10044

Query: 296   MPYP-PQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNP 350
             +P P P+ V  P +   +VP      +         VP  + +PP + P+ +   P
Sbjct: 10045 VPVPAPKKVEAPPAKVPEVPKKLIPEEKKP----TPVPKKVEAPPPKVPKKREPVP 10096



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 10/112 (8%)

Query: 103 IEAHKRGSVFMCSIVQQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQT 162
           + A K  ++   + + + ++T + +K ++AH   R     + V   +  +  PH  PP+ 
Sbjct: 199 VPAKKTKTIVSTAQISESRQTRI-EKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPR- 256

Query: 163 EISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHN-QPHKDIQAPPP 213
               IP + + R   S  PP       L   Q     +H+  P + ++AP P
Sbjct: 257 ----IPPKPKSR---SPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTP 301


>gi|239753480 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1344

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 49/201 (24%), Positives = 75/201 (37%), Gaps = 29/201 (14%)

Query: 205 HKDIQAPPPELSLSLPFPIQWETVSIFTRK----HGNL------TVDHIQNNSDSGAKKP 254
           H+ +   PP  S   P P   +T++ FT      HG        T+     +  S    P
Sbjct: 319 HRSVHGTPPLCSRDTP-PSSRDTIAQFTGHPHSVHGTPPLSSRDTIAQFTGHPHSVHGTP 377

Query: 255 TPPDYYPECQSQ--PAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRS- 311
            P    P   S+  P   + HH   +  H  PP S           P Q    P+SV   
Sbjct: 378 HPVHRTPPLSSRDTPTQFTGHH---RSVHGTPPLSSQDTPPSSQDNPAQFAGHPHSVHGT 434

Query: 312 -----QVPALTTTYDPSS---GYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLN 363
                + P L++   P+     +  V   P ++S     P S   NP+  +FA H ++++
Sbjct: 435 PHPVHRTPPLSSRDTPTQFTGHHCSVHGTPPLSSQD--TPPSSQDNPA--QFAGHPHSVH 490

Query: 364 ILPQFTENQETLSPQFTQTDA 384
             P  + +   L PQ T T A
Sbjct: 491 ETPLLSNSHYLLHPQVTATPA 511


>gi|239508790 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 490

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 33/101 (32%), Positives = 41/101 (40%), Gaps = 14/101 (13%)

Query: 254 PTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSV---R 310
           P+PP   P   S   V SP   +P      P P    P+   +P PP DV   + V    
Sbjct: 171 PSPPSDVPSLLS--GVPSPPSDVPSPPSDVPSPPSDVPLLSDVPSPPSDVPLLSDVPSPP 228

Query: 311 SQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPS 351
           S VP+L +     SG     VP    SPP   P   +G PS
Sbjct: 229 SDVPSLPSDVPSLSG-----VP----SPPSDVPSLLSGVPS 260



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 48/190 (25%), Positives = 66/190 (34%), Gaps = 33/190 (17%)

Query: 164 ISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPH------KDIQAPPPELSL 217
           +SD+P    D   LS +P     + SLPS    L    + P         + +PP ++S 
Sbjct: 208 LSDVPSPPSDVPLLSDVPSPPSDVPSLPSDVPSLSGVPSPPSDVPSLLSGVPSPPSDISP 267

Query: 218 SLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIP 277
               P     V        +L          SG   P+PP   P   S          +P
Sbjct: 268 PSDVPSLLSDVPSLPSDVPSLL---------SGV--PSPPSDVPSLLSD---------VP 307

Query: 278 QKQHYAPPPSPSSPVNHQMPYPPQDVVTP----NSVRSQVPALTTTYDPSSGYIIVKVPP 333
                 P P    P+   +P PP DV +P     S  S VP L+    P S   ++   P
Sbjct: 308 SPPSDVPSPPSDIPLLSGVPSPPSDVPSPPSDVPSPPSDVPLLSGVPSPLSDVPLLSGVP 367

Query: 334 DMNSPPLRAP 343
              SPP   P
Sbjct: 368 ---SPPSDVP 374



 Score = 35.4 bits (80), Expect = 0.099
 Identities = 34/109 (31%), Positives = 43/109 (39%), Gaps = 13/109 (11%)

Query: 255 TPPDYYPECQSQ-----PAVSSPHHIIPQKQHYAP-PPSPSSPVNHQMPYPPQDVVTP-- 306
           +PP   P   S        V SP   +P      P PPS    +   +P PP DV +P  
Sbjct: 137 SPPSDVPSLLSDVPSLLSGVPSPPSDVPSPPSDVPSPPSDVPSLLSGVPSPPSDVPSPPS 196

Query: 307 --NSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSAS 353
              S  S VP L+    P S    V +  D+ SPP   P   +  PS S
Sbjct: 197 DVPSPPSDVPLLSDVPSPPSD---VPLLSDVPSPPSDVPSLPSDVPSLS 242



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 51/177 (28%), Positives = 67/177 (37%), Gaps = 46/177 (25%)

Query: 176 HLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPP-PELSLSLPFPIQWETVSIFTRK 234
           H   +PP  H +VSL    H L      PH  + +P  P +SL  P    +  VS     
Sbjct: 20  HCPLVPPH-HPLVSL---HHPLVS----PHFPLVSPHHPLVSLHHPVSPHFPLVS----P 67

Query: 235 HGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNH 294
           H  L   H    S         P Y P     P VS PH+ +      +P     SP+  
Sbjct: 68  HHPLMSPHYSLVS---------PQYSPVSPHCPLVS-PHYSL-----VSPHRPLVSPLLS 112

Query: 295 QMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPS 351
            +P PP DV    S+ S VP+L               P D++SPP   P   +  PS
Sbjct: 113 GVPSPPSDVP---SLLSGVPSL---------------PSDVSSPPSDVPSLLSDVPS 151


>gi|31543543 retinoic acid induced 17 [Homo sapiens]
          Length = 1067

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 56/233 (24%), Positives = 82/233 (35%), Gaps = 37/233 (15%)

Query: 167  IPKRLQDRDHLSYIPPEQHTMVS-----LPSVQHMLQEQHNQPHKDIQAPPPELSLSLPF 221
            I   L  +D    IP ++   +S     +P+V  M+      P      PPP  + S  +
Sbjct: 827  IKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDY 886

Query: 222  PIQ---WETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDY------------YPECQSQ 266
              Q   ++    F   HGN     + +      +   PPD             +P  ++ 
Sbjct: 887  SSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETM 946

Query: 267  PAVSS---PHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPS 323
            P   S   PH  I Q  H   P S S P  H    PP     P+    Q P    +  P 
Sbjct: 947  PHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPP---PPSQPPRQPPQAAPSSHPH 1003

Query: 324  SGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLS 376
            S         D+   P  A + Q G   AS+      +L++LP+ T   E LS
Sbjct: 1004 S---------DLTFNPSSALEGQAGAQGASDMPEP--SLDLLPELTNPDELLS 1045



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 30/114 (26%), Positives = 46/114 (40%), Gaps = 13/114 (11%)

Query: 250 GAKKPTPPDYYPECQSQPA--VSSPHHIIPQ--KQHYAPPPS-PSSPVNHQMPYPPQDVV 304
           G + P      P  QS P   +  P+   P    Q Y P    P+ P  +  P PP+ + 
Sbjct: 382 GQRMPQQTYPGPRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLT 441

Query: 305 TPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASH 358
           +PN    ++P+      PSSG      PP +N      P+  NG  +    +S+
Sbjct: 442 SPNYPGQRMPS-----QPSSGQY---PPPTVNMGQYYKPEQFNGQNNTFSGSSY 487


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 32/97 (32%), Positives = 38/97 (39%), Gaps = 5/97 (5%)

Query: 249 SGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQM-PYPPQDVVTPN 307
           SG K P PP    + Q QP    P     Q   + PPP P  P   Q  P PPQD   P 
Sbjct: 54  SGPKPPIPPPPPHQQQQQPPPQQPPP--QQPPPHQPPPHPQ-PHQQQQPPPPPQDSSKPV 110

Query: 308 SVRSQVPAL-TTTYDPSSGYIIVKVPPDMNSPPLRAP 343
             +   PA    +  P+S       PP   +PP   P
Sbjct: 111 VAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGP 147



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 30/97 (30%), Positives = 35/97 (36%), Gaps = 5/97 (5%)

Query: 256 PPDYYPECQSQPAVSSPHHIIPQKQHYAPPP--SPSSPVNHQMPYPPQDVVTPNSVRSQV 313
           PP   P  Q  P    P H  P +Q   PPP    S PV  Q P P   V +     S  
Sbjct: 72  PPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSA 131

Query: 314 PALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNP 350
           P  T    P+SG      P    +PP     +  G P
Sbjct: 132 PPAT---PPTSGAPPGSGPGPTPTPPPAVTSAPPGAP 165



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 39/150 (26%), Positives = 47/150 (31%), Gaps = 25/150 (16%)

Query: 181 PPEQHTMVSLPSVQHMLQEQ--------HNQPHKDIQAPPPELSLSLPFPIQWETVSIFT 232
           PP  H     P  Q    +Q        H QPH+  Q PPP    S P         +  
Sbjct: 62  PPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKP---------VVA 112

Query: 233 RKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPA-VSSPHHIIPQKQHYAPPPSPSS- 290
           +  G          + S A   TPP       S P    +P   +      APPP+P S 
Sbjct: 113 QGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSS 172

Query: 291 ------PVNHQMPYPPQDVVTPNSVRSQVP 314
                 P     P PP  V  P     Q P
Sbjct: 173 GVPTTPPQAGGPPPPPAAVPGPGPGPKQGP 202


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 39/161 (24%), Positives = 57/161 (35%), Gaps = 35/161 (21%)

Query: 192 SVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGA 251
           S Q   Q +H   H     PP  + + L  P +   V             ++  +     
Sbjct: 116 SYQKQQQYKHQMLHHQRDGPPGLVPMELESPPESPPVP---------PGSYMPPSQSYMP 166

Query: 252 KKPTPPDYYPECQSQ----PAVSSPHHIIPQKQHYAPPPSPSSP-------VNHQMPYPP 300
               PP YYP   SQ    PA  SP    P + + AP PS SS        ++H   Y P
Sbjct: 167 PPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLP 226

Query: 301 QDVVTPNSVRSQVPALTTTYDPSSGYIIVKV--PPDMNSPP 339
               +P+              PS G+   ++  PP  ++PP
Sbjct: 227 SSQASPSR-------------PSQGHSKSQLLAPPPPSAPP 254



 Score = 32.3 bits (72), Expect = 0.84
 Identities = 32/106 (30%), Positives = 44/106 (41%), Gaps = 21/106 (19%)

Query: 241  DHIQNNSDSGAKKPTPPDYYPECQSQ-PAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYP 299
            + +Q   D G++ P   D+ P  +S+    SS   + P    Y PPP         M  P
Sbjct: 1471 EQLQKMKDFGSE-PQMADHLPPQESRLQNTSSRPGMYPPPGSYRPPP--------PMGKP 1521

Query: 300  PQDVVTPNS--VRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAP 343
            P  +V P++   RS VP    T  P      V +PP    PPL  P
Sbjct: 1522 PGSIVRPSAPPARSSVP---VTRPP------VPIPPPPPPPPLPPP 1558



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 48/221 (21%), Positives = 73/221 (33%), Gaps = 53/221 (23%)

Query: 178 SYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAP-----PPELSLSLPFPIQWETVSIFT 232
           SY+PP Q  M              +QP+     P     PP  S   P P  + + S  +
Sbjct: 156 SYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTP-SYSSSSSSS 214

Query: 233 RKHGNLTVDHI-----------QNNSDSGAKKPTPPDYYP----ECQSQPAVSSPHHIIP 277
           + + + +  ++           Q +S S    P PP   P      Q +P  S   +   
Sbjct: 215 QSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKST 274

Query: 278 QKQHYAPPPSPS--SPVNHQMPYPPQDVV----------------------TPNSVRSQV 313
           ++Q  AP P PS  +P   Q  +  Q ++                      TP  V+ +V
Sbjct: 275 EQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEV 334

Query: 314 PALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASE 354
               T+  P S        P    PPL  P  +   P   E
Sbjct: 335 TVPATSQVPES--------PSSEEPPLPPPNEEVPPPLPPE 367


>gi|23397666 transcriptional co-repressor Sin3A [Homo sapiens]
          Length = 1273

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 59/229 (25%), Positives = 79/229 (34%), Gaps = 43/229 (18%)

Query: 156 HIAPPQTEISDIPK--RLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
           H APP   +    +  RL+  D LSY+   +    S P V +           DI     
Sbjct: 104 HPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYN--------DFLDIMKEFK 155

Query: 214 ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVS--- 270
             S+  P  I    VS   + H +L +         G     PP Y  E Q+   V+   
Sbjct: 156 SQSIDTPGVIS--RVSQLFKGHPDLIM---------GFNTFLPPGYKIEVQTNDMVNVTT 204

Query: 271 -SPHHIIP----QKQHYAPPPSPSSPVNHQMPY--------PPQDVVTPNSVRSQVPALT 317
               H IP    Q Q   PP  PS P     P         PP  V  P+ +++  PA  
Sbjct: 205 PGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQ 264

Query: 318 TTYDPSSGYIIVKVPPDMNSPPL-----RAPQSQNGNPSASEFASHHYN 361
            T  P   Y   + PP     P+      AP  QN  P     A ++ N
Sbjct: 265 QT-PPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVN 312


>gi|223941785 transcriptional co-repressor Sin3A [Homo sapiens]
          Length = 1273

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 59/229 (25%), Positives = 79/229 (34%), Gaps = 43/229 (18%)

Query: 156 HIAPPQTEISDIPK--RLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
           H APP   +    +  RL+  D LSY+   +    S P V +           DI     
Sbjct: 104 HPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYN--------DFLDIMKEFK 155

Query: 214 ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVS--- 270
             S+  P  I    VS   + H +L +         G     PP Y  E Q+   V+   
Sbjct: 156 SQSIDTPGVIS--RVSQLFKGHPDLIM---------GFNTFLPPGYKIEVQTNDMVNVTT 204

Query: 271 -SPHHIIP----QKQHYAPPPSPSSPVNHQMPY--------PPQDVVTPNSVRSQVPALT 317
               H IP    Q Q   PP  PS P     P         PP  V  P+ +++  PA  
Sbjct: 205 PGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQ 264

Query: 318 TTYDPSSGYIIVKVPPDMNSPPL-----RAPQSQNGNPSASEFASHHYN 361
            T  P   Y   + PP     P+      AP  QN  P     A ++ N
Sbjct: 265 QT-PPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVN 312


>gi|223941782 transcriptional co-repressor Sin3A [Homo sapiens]
          Length = 1273

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 59/229 (25%), Positives = 79/229 (34%), Gaps = 43/229 (18%)

Query: 156 HIAPPQTEISDIPK--RLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPP 213
           H APP   +    +  RL+  D LSY+   +    S P V +           DI     
Sbjct: 104 HPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYN--------DFLDIMKEFK 155

Query: 214 ELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVS--- 270
             S+  P  I    VS   + H +L +         G     PP Y  E Q+   V+   
Sbjct: 156 SQSIDTPGVIS--RVSQLFKGHPDLIM---------GFNTFLPPGYKIEVQTNDMVNVTT 204

Query: 271 -SPHHIIP----QKQHYAPPPSPSSPVNHQMPY--------PPQDVVTPNSVRSQVPALT 317
               H IP    Q Q   PP  PS P     P         PP  V  P+ +++  PA  
Sbjct: 205 PGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQ 264

Query: 318 TTYDPSSGYIIVKVPPDMNSPPL-----RAPQSQNGNPSASEFASHHYN 361
            T  P   Y   + PP     P+      AP  QN  P     A ++ N
Sbjct: 265 QT-PPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVN 312


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,989,325
Number of Sequences: 37866
Number of extensions: 1265975
Number of successful extensions: 8257
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 455
Number of HSP's that attempted gapping in prelim test: 6794
Number of HSP's gapped (non-prelim): 1470
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.