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Search of human proteins with 226494053
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo
sapiens]
(316 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo sa... 619 e-177
gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo sa... 324 6e-89
gi|221554526 coiled-coil domain containing 42B [Homo sapiens] 177 1e-44
gi|217272874 coiled-coil domain containing 37 [Homo sapiens] 55 1e-07
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 54 1e-07
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 54 1e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 53 3e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 52 5e-07
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 52 5e-07
gi|148746195 trichohyalin [Homo sapiens] 51 1e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 48 1e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 48 1e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 48 1e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 48 1e-05
gi|146260271 hypothetical protein LOC129881 [Homo sapiens] 47 2e-05
gi|226491199 coiled-coil domain containing 38 [Homo sapiens] 47 3e-05
gi|154354979 myosin X [Homo sapiens] 47 3e-05
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 47 3e-05
gi|38044112 restin isoform b [Homo sapiens] 46 4e-05
gi|4506751 restin isoform a [Homo sapiens] 46 4e-05
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 46 4e-05
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 46 5e-05
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 45 6e-05
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] 45 6e-05
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens] 45 6e-05
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 45 6e-05
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 45 6e-05
gi|21735548 centrosomal protein 2 [Homo sapiens] 45 8e-05
gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromoso... 45 8e-05
gi|16262452 cingulin [Homo sapiens] 45 1e-04
>gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo
sapiens]
Length = 316
Score = 619 bits (1595), Expect = e-177
Identities = 316/316 (100%), Positives = 316/316 (100%)
Query: 1 MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ
Sbjct: 1 MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
Query: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ
Sbjct: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
Query: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180
HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS
Sbjct: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180
Query: 181 MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES 240
MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES
Sbjct: 181 MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES 240
Query: 241 RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS 300
RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS
Sbjct: 241 RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS 300
Query: 301 DIWAEVKKKEQQRVRI 316
DIWAEVKKKEQQRVRI
Sbjct: 301 DIWAEVKKKEQQRVRI 316
>gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo
sapiens]
Length = 242
Score = 324 bits (831), Expect = 6e-89
Identities = 164/164 (100%), Positives = 164/164 (100%)
Query: 1 MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ
Sbjct: 1 MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
Query: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ
Sbjct: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
Query: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164
HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE
Sbjct: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164
>gi|221554526 coiled-coil domain containing 42B [Homo sapiens]
Length = 308
Score = 177 bits (449), Expect = 1e-44
Identities = 107/299 (35%), Positives = 170/299 (56%), Gaps = 4/299 (1%)
Query: 13 EYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETL 72
EYFRL E+L KLP P + LLEK++E Q + +K++F+ + L
Sbjct: 7 EYFRLALQEKLST---KLPEQAEDHVPPVLRLLEKRQELVDADQALQAQKEVFRTKTAAL 63
Query: 73 NLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEM 132
RWE+L KE +LK + ++F+Q+++ +R RA+++A +ER + E + ++
Sbjct: 64 KQRWEQLEQKERELKGSFIRFDKFLQDSEARRNRALRRAAEERHQAGRREVEALRLWTQL 123
Query: 133 VALRLEHQRLSAKLKDYYIFNKYLEKVVENSE-FEEIHEVIARYKTLVSMRHDLMQSAQE 191
LR EH RL +LK + LE+ +E F+E+ E++AR+ L + L +E
Sbjct: 124 QELRREHARLQRRLKRLEPCARLLEQALELLPGFQEVPELVARFDGLAETQAALRLRERE 183
Query: 192 GQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAK 251
++E A+ARL + + DE+L Q A+LQ R + AR + WES+W IQNTAA+
Sbjct: 184 QLAELEAARARLQQLRDAWPDEVLAQGQRRAQLQERLEAARERTLQWESKWIQIQNTAAE 243
Query: 252 KTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKE 310
KTLLLG +MA LNLFQ+V +H + + +EDT QL+ ++ F+QD S + A + + E
Sbjct: 244 KTLLLGRSRMAVLNLFQLVCQHQGQPPTLDIEDTEGQLEHVKLFMQDLSAMLAGLGQAE 302
>gi|217272874 coiled-coil domain containing 37 [Homo sapiens]
Length = 611
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 36/198 (18%)
Query: 22 RLLQMLQKLPNVEGASESP--------SIWLL----EKKKETEIMHQTMVQKKKMFQ--- 66
R LQ+ K ++E +E+ + W L EK E E M + QK++MF
Sbjct: 104 RQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQY 163
Query: 67 ---------RRMETLNLRWE-ELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERE 116
+R+ETL + E L E L+ ++F++END ++AM+ A KE +
Sbjct: 164 ALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK 223
Query: 117 LKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYK 176
K + + E+ ++V ++ E R LK Y ++ +L K+ EE +
Sbjct: 224 AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEK------ 277
Query: 177 TLVSMRHDLMQSAQEGQE 194
+H ++ A+E E
Sbjct: 278 -----KHSFLKKAKEVSE 290
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 54.3 bits (129), Expect = 1e-07
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 40/279 (14%)
Query: 38 ESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI----QKS 93
E +I E K T + +Q +K + ++ +E + EL E Q I +K
Sbjct: 1146 EESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKY 1205
Query: 94 EQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
E IQ ++ R + + ++RE Q +Q+L K E + L+ +L ++ +
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDRE---QLIQKLNCEKDEAIQTALKEFKLEREVVE----K 1258
Query: 154 KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
+ LEKV + + IA+ + S R D E QEK++ KA+ +EE++
Sbjct: 1259 ELLEKV------KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEK- 1311
Query: 214 ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
++N E+ + R + I +L KM N+ +S
Sbjct: 1312 --RKNEEMQNV----------------RTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
Query: 274 LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
LK ++ + D+I+ +DR+ + E KK E++
Sbjct: 1354 LKS----TMQQQERDKDLIESLSEDRARLLEEKKKLEEE 1388
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 54.3 bits (129), Expect = 1e-07
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 40/279 (14%)
Query: 38 ESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI----QKS 93
E +I E K T + +Q +K + ++ +E + EL E Q I +K
Sbjct: 1146 EESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKY 1205
Query: 94 EQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
E IQ ++ R + + ++RE Q +Q+L K E + L+ +L ++ +
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDRE---QLIQKLNCEKDEAIQTALKEFKLEREVVE----K 1258
Query: 154 KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
+ LEKV + + IA+ + S R D E QEK++ KA+ +EE++
Sbjct: 1259 ELLEKV------KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEK- 1311
Query: 214 ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
++N E+ + R + I +L KM N+ +S
Sbjct: 1312 --RKNEEMQNV----------------RTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
Query: 274 LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
LK ++ + D+I+ +DR+ + E KK E++
Sbjct: 1354 LKS----TMQQQERDKDLIESLSEDRARLLEEKKKLEEE 1388
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 53.1 bits (126), Expect = 3e-07
Identities = 53/279 (18%), Positives = 127/279 (45%), Gaps = 17/279 (6%)
Query: 50 ETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMK 109
E E + + KK+ + L R EE + L+A +K +Q IQE +++
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 110 KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIH 169
K + K +L K ++E + L ++ +L+ + K + ++ E +E EE
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK--LLEDRIAEFTTNLTEEEEKS 1015
Query: 170 EVIARYK----TLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
+ +A+ K +++ + ++ ++ ++++E+ + +L + D+I + ++A L+
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 226 MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI-----VSKHLKEVTEV 280
M+ + + ++ A ++ AA+K + L I+ + ++ + + E
Sbjct: 1076 MQLAKKEEEL---QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 281 ALEDTHKQLDMIQQFIQDRSDIWA---EVKKKEQQRVRI 316
D ++L+ ++ ++D D A E++ K +Q V I
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Score = 47.0 bits (110), Expect = 2e-05
Identities = 46/232 (19%), Positives = 103/232 (44%), Gaps = 18/232 (7%)
Query: 5 IMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKM 64
+ EE AE + Q + ++ ++ N G LE+K+ E + ++ +
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALA----LEEKRRLEARIAQLEEELEE 1740
Query: 65 FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE 124
Q E +N R ++ ++ Q+ + Q+N+ R + +++ NKE ++K Q M+
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR-QQLERQNKELKVKLQEMEG 1799
Query: 125 LTKRKQE--MVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
K K + + AL + +L +L + E + +++ + K ++
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDN--------ETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 183 HDLMQSAQEGQEKIERAKARLA---RYMEEKDDEILQQNNELARLQMRFDRA 231
D ++A++ +++ ++A RL R +EE ++E + N +LQ + A
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 35.4 bits (80), Expect = 0.067
Identities = 53/241 (21%), Positives = 101/241 (41%), Gaps = 36/241 (14%)
Query: 9 EDLAEYFRLQYGERLLQMLQK----LPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKM 64
E+LAE +L+ +R+ L+K L N G + LL+ K ++E K+K
Sbjct: 1199 EELAE--QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE-------HKRKK 1249
Query: 65 FQRRMETLNLRWEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKEREL 117
+ +++ L +++ E L K +L+ + + ++D K + K + E
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA-LES 1308
Query: 118 KCQHMQELTKRKQEMVALRLEHQRLSAKLK----DYYIFNKYLEKVVE-----NSEFEEI 168
+ Q QEL + + + LS KLK + F + LE+ E + +
Sbjct: 1309 QLQDTQELLQEENR------QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 169 HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRF 228
H +A K + +++A+E + K+++ L++ EEK + RLQ
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 229 D 229
D
Sbjct: 1423 D 1423
Score = 33.1 bits (74), Expect = 0.33
Identities = 66/290 (22%), Positives = 125/290 (43%), Gaps = 25/290 (8%)
Query: 28 QKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRME--TLNLRWEELGVKEAQ 85
QKL + +E+ L E++ E + + ++KK+ + R+ T NL EE ++++
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE---EKSK 1016
Query: 86 LKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQ--RLS 143
A ++ + + + ++R+R RE K + E T+RK E + L Q L
Sbjct: 1017 SLAKLKNKHEAMITDLEERLR--------REEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 144 AKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARL 203
A++ + + E+ ++ + + E A+ + +L E QE +E +A
Sbjct: 1069 AQIAELKMQLAKKEEELQ-AALARVEEEAAQKNMALKKIRELESQISELQEDLESERA-- 1125
Query: 204 ARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMAT 263
+R EK L + E + ++ D S E R Q K L K
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELE-DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 264 LNLFQIVSKHLKEVTEVA--LEDTHK---QLDMIQQFIQ-DRSDIWAEVK 307
+ ++ KH + V E+A LE T + L+ +Q ++ +R ++ EVK
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 52.4 bits (124), Expect = 5e-07
Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 14/193 (7%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
LL++K+ E + ++ + Q ME LN R+ + ++ L A + Q++D
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQ--RLSAKLKDYYIFNKYLEKVVE 161
R + +++ NKE + K Q ++ K K + LE + +L +L+ K+V
Sbjct: 1787 R-QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 162 NSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEILQQN 218
+E + K + D + A + +E++E+A AR L R +EE ++E + N
Sbjct: 1846 RTE--------KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 219 NELARLQMRFDRA 231
+LQ D A
Sbjct: 1898 ASRRKLQRELDDA 1910
Score = 45.4 bits (106), Expect = 6e-05
Identities = 61/329 (18%), Positives = 139/329 (42%), Gaps = 46/329 (13%)
Query: 21 ERLLQMLQKLPNVEGASESPSI---WLLEKKK--------------ETEIMHQTMVQKKK 63
E LL++ +K VEG E LLE+K E E M + KK+
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 64 MFQRRMETLNLRWEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRA-MKKANKER 115
+ + L R EE L ++ +++AHIQ E+ + E + R + ++K E
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 116 ELKCQHMQELTKRKQEMVALRLEHQRL--SAKLKDYYIFNKYLEKVVENSEFEEIHEVIA 173
++K K ++E++ L ++ + KL + I + E + + + ++
Sbjct: 979 KIK--------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 174 RYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
+ + ++S + ++ ++ ++++E+AK +L + D+I + ++ L+++ +
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Query: 234 NVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI-----VSKHLKEVTEVALEDTHKQ 288
+ + A + K L ++ + ++ K + E D ++
Sbjct: 1091 EL---QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 289 LDMIQQFIQDRSDIWA---EVKKKEQQRV 314
L+ ++ ++D D A E++ K +Q V
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEV 1176
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 52.4 bits (124), Expect = 5e-07
Identities = 70/345 (20%), Positives = 145/345 (42%), Gaps = 54/345 (15%)
Query: 10 DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRM 69
DL E + + + LLQ KL +E E + + + + + +K+ Q+ +
Sbjct: 164 DLEEVAK-ERAQNLLQRANKL-RMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKEL 221
Query: 70 ETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRA-------MKKANKER------- 115
+T R +++ E + + IQ+ E+ ++ ++RIR M+K +ER
Sbjct: 222 DTEEKRLDQM--MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQR 279
Query: 116 ------------ELKCQHMQELTKRKQEMVALRLEHQRLS-------------AKLKDYY 150
+L+ + ++++ +R+Q+ + ++ E +R++ KL D
Sbjct: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQM 339
Query: 151 IFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQ-SAQEGQEKIERAKARLARYMEE 209
+ +K+ +EFE E I R K R MQ AQ+ Q + + +A+ R E
Sbjct: 340 VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAK--RNQEV 397
Query: 210 KDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI 269
D E ++ E AR +M + E R + ++ A K+ L ++ +I
Sbjct: 398 ADREWRRKEKENARKKMETEA--------ELRKSRLEQVAFKEHALAVQVQRDRDEFERI 449
Query: 270 VSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQRV 314
+ +++ + LE+ K +Q + R + +K+ Q R+
Sbjct: 450 LRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRI 494
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 51.2 bits (121), Expect = 1e-06
Identities = 53/239 (22%), Positives = 118/239 (49%), Gaps = 20/239 (8%)
Query: 7 EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQ 66
EEE + +L+ ER Q ++ + E L++++E E + Q + ++++ +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 67 RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQ-ENDQKRIRAMKKANKERELKCQHMQE- 124
+ E R E+L +E + + ++ EQ ++ E +++R + +K+ + R+ + + QE
Sbjct: 541 EQEE----RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 125 -LTKR-KQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
L +R K+E V + +R +LK + ++++++ E EE R + L +
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE-----RRQQQLRREQ 651
Query: 183 HDLMQSAQEGQEKIERAKARLARYMEE--KDDEILQQNNELARLQMRFDRARSNVIFWE 239
+ + + +E+ ER + RL R EE ++ E+ ++ E AR +R +S + W+
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-----ERIKSRIPKWQ 705
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/221 (21%), Positives = 100/221 (45%), Gaps = 20/221 (9%)
Query: 7 EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQ 66
+EE + R + ER Q L++ E + E+++E ++ + +++++ +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 67 RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
R + LR E+ +E QL+ + +Q +E +R + +++ +E + +H QE
Sbjct: 391 REQQ---LRREQQLRREQQLR----REQQLRREQQLRREQQLRREQEEERHEQKHEQE-- 441
Query: 127 KRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLM 186
R+++ + E +R K E+ E E E + + R + L
Sbjct: 442 -RREQRLKREQEERRDWLKR----------EEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 187 QSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMR 227
+E +E+ ER + +L R EE+ ++ L++ E RLQ R
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Score = 44.7 bits (104), Expect = 1e-04
Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 37/220 (16%)
Query: 45 LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGV---------KEAQLKAHIQ---- 91
L++++ETE H+ +K+++ + + E RW +L +E QL+ +
Sbjct: 458 LKREEETE-RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 92 ----------------KSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEM--- 132
+SEQ ++ ++R + K +E+ L+ + ++ KR+QE
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 133 VALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTL--VSMRHDLMQSAQ 190
L+ E +R +LK + LE+ ++ E E + + R + L + Q
Sbjct: 577 QLLKREEERRQQRLKREQ--EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 191 EGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDR 230
+ +E+ ER + +L R +E+ ++ L++ E RL+ R R
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Score = 44.3 bits (103), Expect = 1e-04
Identities = 42/191 (21%), Positives = 84/191 (43%), Gaps = 12/191 (6%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQ-LKAHIQKSEQFIQENDQ 102
LL +++E + + Q ++ + + E L EE + Q L+ +K E+ QE +Q
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 103 K-RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE 161
R K+ +ERE +C+ +EL + +++++ E +R + Y E
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR----------E 1142
Query: 162 NSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL 221
E ++ E + R + R +L + +E +E + + L E++ E +Q E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 222 ARLQMRFDRAR 232
LQ + + R
Sbjct: 1203 EELQRQKRKQR 1213
Score = 42.7 bits (99), Expect = 4e-04
Identities = 55/257 (21%), Positives = 107/257 (41%), Gaps = 36/257 (14%)
Query: 16 RLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLR 75
R + ERL Q L+ + E LL++++E + + Q+ K Q L+
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 76 WEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ-------- 120
EE +E +L+ +++ E E +++R + +K+ E E + Q
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 121 --HMQELTKRKQEMVALRL----EHQRLSAKLKDYYIFNKYLEKVVENSE---FEEIHEV 171
Q+L + +QE RL E +RL +LK + + +++ E + E I
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 172 IARYKTLVSMRHDLMQS-------AQEGQEKIERAKARLARYMEEKDDEILQQNNELARL 224
I +++ + D QS QEGQ + + + + R ++ E+ Q E A
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR----RESELQWQEEERAHR 756
Query: 225 QMRFDRARSNVIF-WES 240
Q + + R + + W++
Sbjct: 757 QQQEEEQRRDFTWQWQA 773
Score = 38.5 bits (88), Expect = 0.008
Identities = 42/185 (22%), Positives = 86/185 (46%), Gaps = 11/185 (5%)
Query: 46 EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRI 105
EK++ E+ Q ++++ Q+ E L LR E + +L+ ++ E+ QE +Q
Sbjct: 1129 EKRRRQELERQ--YREEEEVQQEEEQL-LREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 106 RAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK------LKDYYIFNKYLEKV 159
+K +ERE + + +EL ++K++ R E QR K ++ NK K
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQ-RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 160 VENSEFEEIHEVIAR-YKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQN 218
EN +F ++ + R ++ ++H L + + +E+ R + R+ E++ ++
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 219 NELAR 223
E R
Sbjct: 1305 KEAKR 1309
Score = 37.7 bits (86), Expect = 0.013
Identities = 53/261 (20%), Positives = 111/261 (42%), Gaps = 43/261 (16%)
Query: 3 LGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASES--------PSIWLLEKKKETEIM 54
L +EEE+ +LQ ER Q+ ++ ++ E W + ++E +
Sbjct: 831 LQFLEEEE-----QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885
Query: 55 HQTMVQK---KKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQF-----IQENDQKRIR 106
T+ K ++ ++ + L EEL +E + + ++ Q+ +Q+ +++ +R
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 107 AM--KKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164
K+ +ERE + + ++L +++++++ E +R + K Y E E
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR----------EEEE 995
Query: 165 FEEIHEVIARYKTLVSMRH---------DLMQSAQEGQEKIERAKARL-ARYMEEKDDEI 214
++ E + R + R D +Q +E + ER K RL R + +++E
Sbjct: 996 LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055
Query: 215 LQQNNELARLQMRFDRARSNV 235
LQQ E + R R R +
Sbjct: 1056 LQQEEEQLLGEERETRRRQEL 1076
Score = 37.7 bits (86), Expect = 0.013
Identities = 42/186 (22%), Positives = 90/186 (48%), Gaps = 27/186 (14%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLK----AHIQKSEQFIQE 99
LL++++E ++ Q + +K + E LR +E +E QL+ ++ EQ +QE
Sbjct: 1627 LLQEREEQQLHRQE--RDRKFLE---EEPQLRRQE---REQQLRHDRDRKFREEEQLLQE 1678
Query: 100 NDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKV 159
+++++R ++ K RE + Q ++ +RK +L Q L K ++ E++
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE-------EQL 1731
Query: 160 VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
+ +E E++ RY+ +++ Q E+ E+ R R + +++E L+Q
Sbjct: 1732 RQETEQEQLRRQ-ERYR-------KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 220 ELARLQ 225
E +L+
Sbjct: 1784 EEQQLR 1789
Score = 37.4 bits (85), Expect = 0.018
Identities = 43/215 (20%), Positives = 96/215 (44%), Gaps = 42/215 (19%)
Query: 44 LLEKKKETEIMHQT----MVQKKKMFQRRMETLNLRWEELGVKEAQLKA--------HIQ 91
LL++++E ++ Q +++++ +R+ R +EL +E + K Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 92 KSEQFIQENDQKRIRAM---------KKANKERELKCQHMQELTKRKQEMVALRLEHQRL 142
+ +F+QE Q R + +K +E +L+ + ++ R++ RLE Q+
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK- 1587
Query: 143 SAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI-ERAKA 201
+ + + +F E + + R + +R + + +E ++ + ER +
Sbjct: 1588 -------------VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 202 RLARYMEEKDDEILQQNNELAR----LQMRFDRAR 232
+L R +E+D + L++ +L R Q+R DR R
Sbjct: 1635 QLHR--QERDRKFLEEEPQLRRQEREQQLRHDRDR 1667
Score = 35.0 bits (79), Expect = 0.087
Identities = 43/213 (20%), Positives = 94/213 (44%), Gaps = 20/213 (9%)
Query: 25 QMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEA 84
Q+L + P E + E++ + E +++K ++ E + +EL +E
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031
Query: 85 QL------KAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLE 138
QL K +Q+ E+ +E ++ + + +ERE + QEL ++ ++ L+ E
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR--RRQELERQYRKEEELQQE 1089
Query: 139 HQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIER 198
++L + + + + E E ++ E + R + R +L + +E +E++++
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE-EEEVQQ 1148
Query: 199 AKARLARYMEEK-----------DDEILQQNNE 220
+ +L R EK ++E LQQ E
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Score = 34.3 bits (77), Expect = 0.15
Identities = 48/234 (20%), Positives = 97/234 (41%), Gaps = 38/234 (16%)
Query: 7 EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLL--------EKKKETEIM---- 54
+E +LAE GE + ++L + +W E++ E E +
Sbjct: 144 QERELAE------GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 55 -HQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANK 113
H+T + RR E L LR + K+ Q + ++ ++ QE ++K R + +
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRR---ERQDRVFQEEEEKEWRKRETVLR 254
Query: 114 ERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIA 173
+ E K Q +E +R++E L+ E ++L + LE+ E +E +
Sbjct: 255 KEEEKLQ--EEEPQRQRE---LQEEEEQL-----------RKLERQELRRERQEEEQQQQ 298
Query: 174 RYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMR 227
R + +R + +E QE+ + R + E ++ ++ ++ E Q+R
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Score = 34.3 bits (77), Expect = 0.15
Identities = 45/204 (22%), Positives = 93/204 (45%), Gaps = 27/204 (13%)
Query: 46 EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI--QKSEQFIQENDQK 103
E+++ + Q ++K +R + L+ R +E QL+A Q+ ++F+ E ++K
Sbjct: 760 EEEQRRDFTWQWQAEEKS--ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRL-----------EHQRLSAKLKDYYIF 152
R ++ +E+EL Q ++E + ++ A +L E +R + +D
Sbjct: 818 EQRRRQRREREKEL--QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD---- 871
Query: 153 NKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEE--- 209
K+ ++ E + H + A+ +R + Q QE +E+++R + R E+
Sbjct: 872 QKWRWQLEEERK-RRRHTLYAKPALQEQLRKE-QQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 210 -KDDEILQQNNELARLQMRFDRAR 232
+++E LQQ E + R R R
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRR 953
Score = 33.9 bits (76), Expect = 0.19
Identities = 37/180 (20%), Positives = 76/180 (42%), Gaps = 13/180 (7%)
Query: 47 KKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK-RI 105
K +E E+ HQ Q +K + E +KE Q ++ +Q Q+ D+K R
Sbjct: 1361 KFREEELRHQE--QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 106 RAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEF 165
+ + +ER+ K + ++ +R++ E Q+L + + + E++++ E
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF---REEEQLLQEREE 1475
Query: 166 EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
+++H K L + QE K + R +E + + L++ +L R Q
Sbjct: 1476 QQLHRQERDRKFL---EEEQQLRRQERDRKFREQELR----SQEPERKFLEEEQQLHRQQ 1528
Score = 33.5 bits (75), Expect = 0.25
Identities = 42/249 (16%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 6 MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
++EE+ LQ E L+ L++ + + ++E ++ + ++++
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLER-QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 66 QRRMETLNLRWEELGVKEAQLKAHIQ--KSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
+ R E R ++ +E QL+ + + +Q +E +++R + +E E + Q ++
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 124 ELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRH 183
+ ++E R + R +L+ E+ + + + + R + L R
Sbjct: 379 REQQLRREQQLRREQQLRREQQLR--------REQQLRREQQLRREQQLRREQQL---RR 427
Query: 184 DLMQSAQEGQEKIERAKARLARYMEE------KDDEILQQNNELARLQMRFDRARSNVIF 237
+ + E + + ER + RL R EE +++E + E + Q++ D+
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER--- 484
Query: 238 WESRWAHIQ 246
RW ++
Sbjct: 485 -RERWLKLE 492
Score = 33.1 bits (74), Expect = 0.33
Identities = 32/165 (19%), Positives = 72/165 (43%), Gaps = 10/165 (6%)
Query: 60 QKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKC 119
++++ R+ R EE V+ + + + EQ +++ ++ R ++ +ERE +
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 120 QHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLV 179
H QE ++ E E Q+L + +D + L +F E + + R +
Sbjct: 1478 LHRQERDRKFLE------EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ--- 1528
Query: 180 SMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARL 224
+ +Q Q+ + + + R R + +++E L+Q E +L
Sbjct: 1529 -RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Score = 28.9 bits (63), Expect = 6.2
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 15/188 (7%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L ++++E ++ Q ++ + F+ + + + +E E + + Q+ +Q +++ +
Sbjct: 1563 LRQEREEQQLSRQ---ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 104 RIRAMKKANKERELKCQHMQELTKR--KQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE 161
+ R ++ +ERE + H QE ++ ++E R E ++ +D K+ E+
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD----RKFREEEQL 1675
Query: 162 NSEFEEIHEVIARYKTLVSMRHDLMQ-SAQEGQEKIERAKARLARYMEE---KDDEILQQ 217
E EE + + R + R + Q QE + K + + +L R E +++E L+Q
Sbjct: 1676 LQEGEE--QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733
Query: 218 NNELARLQ 225
E +L+
Sbjct: 1734 ETEQEQLR 1741
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 23 LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
L + LQ + +E + L KK+E E I+H Q ++KKM Q+
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 68 RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
++ EE L +++ +A I+K E I D + K +KER+L +
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1007
Query: 122 MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
+ +LT ++ + + L+ +H+ L +LK + LEK+ E + +
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 169 HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
HE IA + ++ +L + +E+++ A ARL DDEI Q+NN L +++
Sbjct: 1068 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1114
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L ++K+ E + ++ + Q ME ++ R + + QL + Q+N+
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
R + +++ NKE K M+ K K + LE AK+ LE+ VE
Sbjct: 1787 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1833
Query: 164 EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
E+ + + + K ++ D + A++ +E+ E+ AR L R +EE ++E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 215 LQQNNELARLQMRFDRA 231
+ N +LQ D A
Sbjct: 1894 QRINANRRKLQRELDEA 1910
Score = 39.3 bits (90), Expect = 0.005
Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)
Query: 21 ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
++L + ++ N+E + +I L + KK+ + T + + KK FQ+ +E L ++E
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 78 ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
E +L+ + Q + ++K+ + + +E+ + ++
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 124 ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
E + R++E AL L + L AK ++ NK L+ +E + + +H
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
E+ + L + ++ +E ++++ E AK RL M+ E+D + + NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 221 LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
R Q++ + R AAKK L G +K L + + + +
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1646
Query: 281 ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
L Q+ Q+ ++D R +I+A K+ E++
Sbjct: 1647 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 23 LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
L + LQ + +E + L KK+E E I+H Q ++KKM Q+
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 68 RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
++ EE L +++ +A I+K E I D + K +KER+L +
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1014
Query: 122 MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
+ +LT ++ + + L+ +H+ L +LK + LEK+ E + +
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 169 HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
HE IA + ++ +L + +E+++ A ARL DDEI Q+NN L +++
Sbjct: 1075 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1121
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L ++K+ E + ++ + Q ME ++ R + + QL + Q+N+
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
R + +++ NKE K M+ K K + LE AK+ LE+ VE
Sbjct: 1794 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1840
Query: 164 EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
E+ + + + K ++ D + A++ +E+ E+ AR L R +EE ++E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 215 LQQNNELARLQMRFDRA 231
+ N +LQ D A
Sbjct: 1901 QRINANRRKLQRELDEA 1917
Score = 39.3 bits (90), Expect = 0.005
Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)
Query: 21 ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
++L + ++ N+E + +I L + KK+ + T + + KK FQ+ +E L ++E
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 78 ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
E +L+ + Q + ++K+ + + +E+ + ++
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 124 ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
E + R++E AL L + L AK ++ NK L+ +E + + +H
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
E+ + L + ++ +E ++++ E AK RL M+ E+D + + NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 221 LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
R Q++ + R AAKK L G +K L + + + +
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1653
Query: 281 ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
L Q+ Q+ ++D R +I+A K+ E++
Sbjct: 1654 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 23 LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
L + LQ + +E + L KK+E E I+H Q ++KKM Q+
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 68 RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
++ EE L +++ +A I+K E I D + K +KER+L +
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1014
Query: 122 MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
+ +LT ++ + + L+ +H+ L +LK + LEK+ E + +
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 169 HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
HE IA + ++ +L + +E+++ A ARL DDEI Q+NN L +++
Sbjct: 1075 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1121
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L ++K+ E + ++ + Q ME ++ R + + QL + Q+N+
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
R + +++ NKE K M+ K K + LE AK+ LE+ VE
Sbjct: 1794 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1840
Query: 164 EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
E+ + + + K ++ D + A++ +E+ E+ AR L R +EE ++E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 215 LQQNNELARLQMRFDRA 231
+ N +LQ D A
Sbjct: 1901 QRINANRRKLQRELDEA 1917
Score = 39.3 bits (90), Expect = 0.005
Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)
Query: 21 ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
++L + ++ N+E + +I L + KK+ + T + + KK FQ+ +E L ++E
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 78 ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
E +L+ + Q + ++K+ + + +E+ + ++
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 124 ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
E + R++E AL L + L AK ++ NK L+ +E + + +H
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
E+ + L + ++ +E ++++ E AK RL M+ E+D + + NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 221 LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
R Q++ + R AAKK L G +K L + + + +
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1653
Query: 281 ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
L Q+ Q+ ++D R +I+A K+ E++
Sbjct: 1654 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 23 LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
L + LQ + +E + L KK+E E I+H Q ++KKM Q+
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 68 RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
++ EE L +++ +A I+K E I D + K +KER+L +
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1007
Query: 122 MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
+ +LT ++ + + L+ +H+ L +LK + LEK+ E + +
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 169 HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
HE IA + ++ +L + +E+++ A ARL DDEI Q+NN L +++
Sbjct: 1068 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1114
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L ++K+ E + ++ + Q ME ++ R + + QL + Q+N+
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
R + +++ NKE K M+ K K + LE AK+ LE+ VE
Sbjct: 1787 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1833
Query: 164 EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
E+ + + + K ++ D + A++ +E+ E+ AR L R +EE ++E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 215 LQQNNELARLQMRFDRA 231
+ N +LQ D A
Sbjct: 1894 QRINANRRKLQRELDEA 1910
Score = 39.3 bits (90), Expect = 0.005
Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)
Query: 21 ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
++L + ++ N+E + +I L + KK+ + T + + KK FQ+ +E L ++E
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 78 ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
E +L+ + Q + ++K+ + + +E+ + ++
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 124 ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
E + R++E AL L + L AK ++ NK L+ +E + + +H
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
E+ + L + ++ +E ++++ E AK RL M+ E+D + + NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 221 LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
R Q++ + R AAKK L G +K L + + + +
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1646
Query: 281 ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
L Q+ Q+ ++D R +I+A K+ E++
Sbjct: 1647 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
>gi|146260271 hypothetical protein LOC129881 [Homo sapiens]
Length = 552
Score = 47.0 bits (110), Expect = 2e-05
Identities = 61/262 (23%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 8 EEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQR 67
EED Y L + LQ + +P+ E S+ L + E + KK+M R
Sbjct: 28 EEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTR--EAACLRAERKAKKEMHLR 85
Query: 68 RMETLNLRWEEL--GVKEAQLKAHIQKSEQFIQEND-----------QKRIRAMKKANKE 114
E + W G+KE +L+A ++ E+ E KR +A++ A +
Sbjct: 86 SQEVVK-HWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQY 144
Query: 115 R-----ELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIH 169
+ +K H L R + ++E ++ +K+K + + L+ +E + EE
Sbjct: 145 QFYQTERVKNFHSGLLLSRVMKERDAQIEFRK--SKIKSDKKWEEQLKLNIEKAFKEEQE 202
Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFD 229
+ R++ V++ D ++ +E +E+ ER K EEKD E +++ N L ++MR
Sbjct: 203 KAEKRHRERVALAKDHLKQIKEHEEEEERRKK-----YEEKDAEEIKRQNALYEIEMRKK 257
Query: 230 RARSNVIFWESRWAHIQNTAAK 251
+ ESR +++ K
Sbjct: 258 LEKKREEMHESRRRFLEHMQDK 279
Score = 39.7 bits (91), Expect = 0.004
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 31/222 (13%)
Query: 7 EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETE---IMHQTMVQKKK 63
+EE AE L E + + ++ +E A + + E+ K ++ + M ++
Sbjct: 112 DEEIEAERQILDLEEEIYKQGKRKKAIENAKQY-QFYQTERVKNFHSGLLLSRVMKERDA 170
Query: 64 MFQRRMETL--NLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIR---AMKKANKERELK 118
+ R + + +WEE QLK +I+K+ + QE +KR R A+ K + ++ +
Sbjct: 171 QIEFRKSKIKSDKKWEE------QLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKE 224
Query: 119 CQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTL 178
+ +E K+ +E A ++ Q +++ K LEK + EE+HE R+
Sbjct: 225 HEEEEERRKKYEEKDAEEIKRQNALYEIE----MRKKLEK-----KREEMHESRRRFLEH 275
Query: 179 VSMRHDLMQSAQEGQE-------KIERAKARLARYMEEKDDE 213
+ +H + Q+ QE K +AK RL + +EK+ E
Sbjct: 276 MQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAE 317
>gi|226491199 coiled-coil domain containing 38 [Homo sapiens]
Length = 563
Score = 46.6 bits (109), Expect = 3e-05
Identities = 28/125 (22%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Query: 33 VEGASESPSIW-LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQ 91
+EG+ ++ + +++ ++ + K+ ++ + + +R +L E +L+
Sbjct: 100 IEGSDTKRTVHEFINDQRDRFLLEYALSTKRNTIKKFEKDIAMRERQLKKAEKKLQDDAL 159
Query: 92 KSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYI 151
E+F++ENDQ+ + A+K A +E K Q EL K E+ A++ E + L++Y
Sbjct: 160 AFEEFLRENDQRSVDALKMAAQETINKLQMTAELKKASMEVQAVKSEIAKTEFLLREYMK 219
Query: 152 FNKYL 156
+ +L
Sbjct: 220 YGFFL 224
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 46.6 bits (109), Expect = 3e-05
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%)
Query: 45 LEKKKETEIMHQTMV------------QKKKMF------QRRMETLNLRWEELGVKEA-- 84
LEK++E E+ H MV Q +K+ Q+ LR L +K+A
Sbjct: 734 LEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAI 793
Query: 85 ----QLKAHI-------------QKSEQFIQENDQKRIRAMKKANKERE-----LKCQHM 122
QL+ I ++ E+ QE ++K+ R ++ +ERE L+ Q
Sbjct: 794 VFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQE 853
Query: 123 QELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
+E T+++QE+ AL+ + + LEK EN + EEI + + L M+
Sbjct: 854 EE-TRKQQELEALQKSQKEAE--------LTRELEKQKENKQVEEILRLEKEIEDLQRMK 904
Query: 183 HDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRF 228
Q+++ +A L + E +D E+ + E R F
Sbjct: 905 E---------QQELSLTEASLQKLQERRDQELRRLEEEACRAAQEF 941
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 46.6 bits (109), Expect = 3e-05
Identities = 38/141 (26%), Positives = 69/141 (48%), Gaps = 7/141 (4%)
Query: 85 QLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSA 144
QL+ Q+ EQ QE + R A K+ EL + +QE ++ K+E+ A+RL H++
Sbjct: 404 QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL 463
Query: 145 KLKDYYIFNKYLEKVVENS--EFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI---ERA 199
++ Y + L ++ E+ + EE+ I K L Q+ +E Q ++ + A
Sbjct: 464 GVRARY--ERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 521
Query: 200 KARLARYMEEKDDEILQQNNE 220
K R ++E ++ + QQ E
Sbjct: 522 KGWFERRLKEAEESLQQQQQE 542
Score = 38.1 bits (87), Expect = 0.010
Identities = 69/327 (21%), Positives = 129/327 (39%), Gaps = 73/327 (22%)
Query: 6 MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
+E AE RLQ E L ++ +KL KK+ E + +K+ +F
Sbjct: 213 LESSKQAETSRLQ--EELAKLSEKL-----------------KKKQESFCRLQTEKETLF 253
Query: 66 ---QRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQE-----------NDQKRIRAMKKA 111
+ ++E L R KEA KA + ++++ QE DQ++ ++ A
Sbjct: 254 NDSRNKIEELQQR------KEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 307
Query: 112 NKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN----KYLEKVVENSE--F 165
R L+ Q + ++++ L E+ L L + L + E +
Sbjct: 308 AALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLA 367
Query: 166 EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
E+ + A Y+ L+ + DL QE RA +RL ++E E Q EL
Sbjct: 368 AELQQQQAEYEDLMGQKDDLNSQLQESL----RANSRLLEQLQEIGQEKEQLTQEL---- 419
Query: 226 MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDT 285
+ +A K+ +L + M TL Q S+H +E+ V L
Sbjct: 420 -----------------QEARKSAEKRKAMLDELAMETL---QEKSQHKEELGAVRLRHE 459
Query: 286 HKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
+ L + ++ ++ ++ + K++E++
Sbjct: 460 KEVLGVRARYERELRELHEDKKRQEEE 486
Score = 33.5 bits (75), Expect = 0.25
Identities = 24/100 (24%), Positives = 50/100 (50%), Gaps = 13/100 (13%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK-------EAQLKAHIQKSEQF 96
L E KK E + ++++K R +ETL EEL + + + ++++E+
Sbjct: 476 LHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEES 535
Query: 97 IQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALR 136
+Q+ Q++ A+K+ + QH EL +++E+ +R
Sbjct: 536 LQQQQQEQEEALKQCRE------QHAAELKGKEEELQDVR 569
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 46.2 bits (108), Expect = 4e-05
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 29/209 (13%)
Query: 45 LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK--------EAQLKAHIQKSEQF 96
LEKK ET H + K ++R + EE+ E +LK +++
Sbjct: 965 LEKKMETS--HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
Query: 97 IQENDQKRIRAMK-KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK---------- 145
+QE ++ R +A K KA + E Q M+++TK K E +A + ++ +AK
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 146 --LKDYYIFNKYLEKV-VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQ----EKIER 198
LK+ NK E + VEN + EE + I K + + + + QE E++ R
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 199 AKARLARYMEEKDDEILQQNNELARLQMR 227
++ + + ++ ++E NN+L ++ R
Sbjct: 1143 SRDEVTSH-QKLEEERSVLNNQLLEMKKR 1170
Score = 43.1 bits (100), Expect = 3e-04
Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 37/239 (15%)
Query: 21 ERLLQMLQKL-----PNVEGASESPSIWLLE---------KKKETEIMHQTMVQKKKMFQ 66
E +LQ LQK ++GA E S L E K K + M ++M +
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054
Query: 67 RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
+ ETL + Q A +Q ++EN+ K + + K+ + ++ Q M+E
Sbjct: 1055 EKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 127 K-----------RKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARY 175
K + Q++ AL+ E+ +L+ +L + ++V + + EE V+
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEEL------GRSRDEVTSHQKLEEERSVLNNQ 1163
Query: 176 KTLVSMRHD-LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
+ R ++ A E + ++++ + + + EKD E+ + NE+ L+ A+S
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222
Score = 42.0 bits (97), Expect = 7e-04
Identities = 55/287 (19%), Positives = 123/287 (42%), Gaps = 34/287 (11%)
Query: 48 KKETEIMHQTMVQKKKM--FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK-- 103
+++ E+++Q +K+K+ Q R+E ++ +L V K+ I + E+ + Q+
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481
Query: 104 RIRAMKKANK---ERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDY----------- 149
+R ++NK + ++ +QE++ ++++ R +HQR LK++
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 150 ----YIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLAR 205
Y + L K E+ + + H + + L + Q+ +E K ++
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
Query: 206 YMEEKDDEILQQNNELARLQMRFDRARSNVIFWE--SRWAHIQNTAAKKTLLLGTIKMAT 263
+ + E + ++ ++++ + N+ + R AH + A + L+ IK
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
Query: 264 LNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKE 310
+L I SK L + + L + L+ +Q+ AE+K KE
Sbjct: 662 NSLEAIRSK-LDKAEDQHLVEMEDTLNKLQE---------AEIKVKE 698
Score = 33.1 bits (74), Expect = 0.33
Identities = 43/202 (21%), Positives = 88/202 (43%), Gaps = 32/202 (15%)
Query: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQEN-DQKRIRAMKKANKERELKC 119
+K + + E LR ++L E Q+K H++ I++N + + ++ + + RELK
Sbjct: 734 RKASSEGKSEMKKLR-QQLEAAEKQIK-HLE-----IEKNAESSKASSITRELQGRELKL 786
Query: 120 QHMQE-LTKRKQEMVALRLEHQRLSAKLKD------------YYIFNKYLEKVVE----N 162
++QE L++ Q L E Q L K + NK +K + +
Sbjct: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
Query: 163 SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL- 221
S+ E++ E +A + + + + + +EK+E A + + + ++ + N+EL
Sbjct: 847 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 906
Query: 222 ------ARLQMRFDRARSNVIF 237
LQ++ +A N F
Sbjct: 907 LKERDVEELQLKLTKANENASF 928
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 46.2 bits (108), Expect = 4e-05
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 29/209 (13%)
Query: 45 LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK--------EAQLKAHIQKSEQF 96
LEKK ET H + K ++R + EE+ E +LK +++
Sbjct: 1000 LEKKMETS--HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057
Query: 97 IQENDQKRIRAMK-KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK---------- 145
+QE ++ R +A K KA + E Q M+++TK K E +A + ++ +AK
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 146 --LKDYYIFNKYLEKV-VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQ----EKIER 198
LK+ NK E + VEN + EE + I K + + + + QE E++ R
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 199 AKARLARYMEEKDDEILQQNNELARLQMR 227
++ + + ++ ++E NN+L ++ R
Sbjct: 1178 SRDEVTSH-QKLEEERSVLNNQLLEMKKR 1205
Score = 43.1 bits (100), Expect = 3e-04
Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 37/239 (15%)
Query: 21 ERLLQMLQKL-----PNVEGASESPSIWLLE---------KKKETEIMHQTMVQKKKMFQ 66
E +LQ LQK ++GA E S L E K K + M ++M +
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089
Query: 67 RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
+ ETL + Q A +Q ++EN+ K + + K+ + ++ Q M+E
Sbjct: 1090 EKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
Query: 127 K-----------RKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARY 175
K + Q++ AL+ E+ +L+ +L + ++V + + EE V+
Sbjct: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEEL------GRSRDEVTSHQKLEEERSVLNNQ 1198
Query: 176 KTLVSMRHD-LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
+ R ++ A E + ++++ + + + EKD E+ + NE+ L+ A+S
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
Score = 39.7 bits (91), Expect = 0.004
Identities = 58/326 (17%), Positives = 140/326 (42%), Gaps = 35/326 (10%)
Query: 10 DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTM--VQKKKMFQR 67
+ A+ +++ +L + +K+ +++ E SI + + +T++ H + +++ +F++
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 68 -RMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK--RIRAMKKANK---ERELKCQH 121
+ + L E+ V K+ I + E+ + Q+ +R ++NK + ++
Sbjct: 478 TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 537
Query: 122 MQELTKRKQEMVALRLEHQRLSAKLKDY---------------YIFNKYLEKVVENSEFE 166
+QE++ ++++ R +HQR LK++ Y + L K E+ + +
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 597
Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQM 226
H + + L + Q+ +E K ++ + + E + ++ ++++
Sbjct: 598 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL 657
Query: 227 RFDRARSNVIFWE--SRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALED 284
+ N+ + R AH + A + L+ IK +L I SK L + + L +
Sbjct: 658 DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK-LDKAEDQHLVE 716
Query: 285 THKQLDMIQQFIQDRSDIWAEVKKKE 310
L+ +Q+ AE+K KE
Sbjct: 717 MEDTLNKLQE---------AEIKVKE 733
Score = 33.1 bits (74), Expect = 0.33
Identities = 43/202 (21%), Positives = 88/202 (43%), Gaps = 32/202 (15%)
Query: 61 KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQEN-DQKRIRAMKKANKERELKC 119
+K + + E LR ++L E Q+K H++ I++N + + ++ + + RELK
Sbjct: 769 RKASSEGKSEMKKLR-QQLEAAEKQIK-HLE-----IEKNAESSKASSITRELQGRELKL 821
Query: 120 QHMQE-LTKRKQEMVALRLEHQRLSAKLKD------------YYIFNKYLEKVVE----N 162
++QE L++ Q L E Q L K + NK +K + +
Sbjct: 822 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 881
Query: 163 SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL- 221
S+ E++ E +A + + + + + +EK+E A + + + ++ + N+EL
Sbjct: 882 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 941
Query: 222 ------ARLQMRFDRARSNVIF 237
LQ++ +A N F
Sbjct: 942 LKERDVEELQLKLTKANENASF 963
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 46.2 bits (108), Expect = 4e-05
Identities = 54/284 (19%), Positives = 118/284 (41%), Gaps = 22/284 (7%)
Query: 45 LEKKKET---------EIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQ 95
LEKK +T E + + KK+ ++ E+LN WE+ K A +++ +
Sbjct: 315 LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEK---KLHNAVAEMEQEKF 371
Query: 96 FIQENDQKRIRAMKKANKER--ELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
+Q+ + I+ + + R +++ ++M + + L Q+L+ + ++ +
Sbjct: 372 DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQR 431
Query: 154 KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
+ L + E +E E +++ V R + + ++ +L + + D
Sbjct: 432 QKL--IQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
Query: 214 ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
+L+Q + L+ +A S + E ++ + L N FQ+ H
Sbjct: 490 LLKQEHALSA-----SKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544
Query: 274 LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAE-VKKKEQQRVRI 316
LK + E D +LD ++ Q + + E +K+KE+Q R+
Sbjct: 545 LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV 588
Score = 37.4 bits (85), Expect = 0.018
Identities = 35/180 (19%), Positives = 81/180 (45%), Gaps = 18/180 (10%)
Query: 52 EIMHQTMVQKKKMFQ----RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQ-------EN 100
E + Q + Q K+ Q +R + L + + ++++ LK +K +Q E+
Sbjct: 507 EELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKED 566
Query: 101 DQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVV 160
QK+I ++A KE+E + + E+ + + + LE + +L ++ + E
Sbjct: 567 TQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKE--- 623
Query: 161 ENSEFEEIHEVIARYKTL-VSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
+ E++ + R K+L + + ++ +++ E+ L E++ +LQQ+N
Sbjct: 624 ---QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHN 680
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 45.8 bits (107), Expect = 5e-05
Identities = 54/229 (23%), Positives = 102/229 (44%), Gaps = 39/229 (17%)
Query: 85 QLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSA 144
QL+ Q+ EQ QE + R A K+ EL + +QE ++ K+E+ A+RL H++
Sbjct: 351 QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL 410
Query: 145 KLKDYYIFNKYLEKVVENS--EFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI---ERA 199
++ Y + L ++ E+ + EE+ I K L Q+ +E Q ++ + A
Sbjct: 411 GVRARY--ERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 468
Query: 200 KARLARYMEE---KDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLL 256
K R ++E K++E+ ++L + Q E R H++ ++ K +
Sbjct: 469 KGWFERRLKEAEGKEEELQDVRDQLEQAQ-------------EERDCHLKTISSLKQEVK 515
Query: 257 GTIKMATLNLFQIVSKHLKEVTEVALEDTHKQL-------DMIQQFIQD 298
T+ + L++ AL+D +QL D +Q+ +QD
Sbjct: 516 DTVDGQRI---------LEKKGSAALKDLKRQLHLERKRADKLQERLQD 555
Score = 38.1 bits (87), Expect = 0.010
Identities = 69/327 (21%), Positives = 129/327 (39%), Gaps = 73/327 (22%)
Query: 6 MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
+E AE RLQ E L ++ +KL KK+ E + +K+ +F
Sbjct: 160 LESSKQAETSRLQ--EELAKLSEKL-----------------KKKQESFCRLQTEKETLF 200
Query: 66 ---QRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQE-----------NDQKRIRAMKKA 111
+ ++E L R KEA KA + ++++ QE DQ++ ++ A
Sbjct: 201 NDSRNKIEELQQR------KEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 254
Query: 112 NKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN----KYLEKVVENSE--F 165
R L+ Q + ++++ L E+ L L + L + E +
Sbjct: 255 AALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLA 314
Query: 166 EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
E+ + A Y+ L+ + DL QE RA +RL ++E E Q EL
Sbjct: 315 AELQQQQAEYEDLMGQKDDLNSQLQESL----RANSRLLEQLQEIGQEKEQLTQEL---- 366
Query: 226 MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDT 285
+ +A K+ +L + M TL Q S+H +E+ V L
Sbjct: 367 -----------------QEARKSAEKRKAMLDELAMETL---QEKSQHKEELGAVRLRHE 406
Query: 286 HKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
+ L + ++ ++ ++ + K++E++
Sbjct: 407 KEVLGVRARYERELRELHEDKKRQEEE 433
Score = 31.6 bits (70), Expect = 0.96
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 23/120 (19%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEEL-----------GVKEAQLKAHIQK 92
L E KK E + ++++K R +ETL EEL G E +LK K
Sbjct: 423 LHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGK 482
Query: 93 SEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMV----ALRLEHQRLSAKLKD 148
E+ DQ +++A +ER+ H++ ++ KQE+ R+ ++ SA LKD
Sbjct: 483 EEELQDVRDQ-----LEQAQEERDC---HLKTISSLKQEVKDTVDGQRILEKKGSAALKD 534
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 45.4 bits (106), Expect = 6e-05
Identities = 53/254 (20%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 46 EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKE-------AQLKAHIQKSEQFIQ 98
+ + + + +Q QK+K+ + ++ L+ + L KE +Q ++ IQ+ E ++
Sbjct: 391 QNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLK 450
Query: 99 --ENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYL 156
EN++++ K+N+E ++L+K +QE ALR E+ RL KL + ++ N Y
Sbjct: 451 QLENEKRKYDEHVKSNQELS------EKLSKLQQEKEALREEYLRL-LKLLNVHVRN-YN 502
Query: 157 EKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEG----QEKIERAKARLARYMEEKD- 211
EK + + ++ +V R V +R + ++ Q KIE+ KA + + D
Sbjct: 503 EK--HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDT 560
Query: 212 ---------DEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMA 262
+++++Q + + +S V++ + +Q + + T +G ++
Sbjct: 561 LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERI 620
Query: 263 TLNLFQIVSKHLKE 276
++ ++LKE
Sbjct: 621 IRSIHIRRGENLKE 634
>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
Length = 1505
Score = 45.4 bits (106), Expect = 6e-05
Identities = 56/230 (24%), Positives = 107/230 (46%), Gaps = 17/230 (7%)
Query: 17 LQYGERLLQMLQKLPNVEGASESPSIWLLEKKKE-TEIMHQTMVQK--KKMFQRRMETLN 73
L G++L +Q+L ++E ++ L E KE E+ +Q + K K+ + +TL
Sbjct: 95 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK 154
Query: 74 LRWEELGV-KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE-LTKRKQE 131
+ E + + KE +L+ + E+ +QE +++A E K Q +Q L K + E
Sbjct: 155 NQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEA----EHKVQSLQTALEKTRTE 210
Query: 132 MVALRLEH-QRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDL----- 185
+ L+ ++ + +AK + + LE+ + +E + E + L S H L
Sbjct: 211 LFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ-REAETLREQLSSANHSLQLASQ 269
Query: 186 MQSAQEGQEKIE-RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSN 234
+Q A + ++ IE ++ L + K+ EI Q ++ RLQ + R N
Sbjct: 270 IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319
Score = 32.0 bits (71), Expect = 0.74
Identities = 55/299 (18%), Positives = 116/299 (38%), Gaps = 23/299 (7%)
Query: 30 LPNVEGASESPSIWLLE-----KKKETEIMHQTMVQKKKMFQRRMETLNLRWEE-----L 79
L N + SE L+E KK E + + + K FQ ++ L+ R +E L
Sbjct: 20 LANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL 79
Query: 80 GVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEH 139
V + + + + Q +++ + E + + ++E K E+ +
Sbjct: 80 NVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTI 139
Query: 140 QRLSAKLKDYYIFNKYL--------EKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQE 191
+ L K+++Y K E+ ++N E+ ++ + S + Q
Sbjct: 140 KALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQS 199
Query: 192 GQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRA--RSNVIFWESRWAHIQNTA 249
Q +E+ + L + D+E + +E+ + +RA R+ V E+ Q ++
Sbjct: 200 LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS 259
Query: 250 AKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKK 308
A +L L + ++ Q + + EV L ++ I Q ++D + A + K
Sbjct: 260 ANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE---IAQLVEDVQRLQASLTK 315
>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
Length = 678
Score = 45.4 bits (106), Expect = 6e-05
Identities = 56/230 (24%), Positives = 107/230 (46%), Gaps = 17/230 (7%)
Query: 17 LQYGERLLQMLQKLPNVEGASESPSIWLLEKKKE-TEIMHQTMVQK--KKMFQRRMETLN 73
L G++L +Q+L ++E ++ L E KE E+ +Q + K K+ + +TL
Sbjct: 106 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK 165
Query: 74 LRWEELGV-KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE-LTKRKQE 131
+ E + + KE +L+ + E+ +QE +++A E K Q +Q L K + E
Sbjct: 166 NQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEA----EHKVQSLQTALEKTRTE 221
Query: 132 MVALRLEH-QRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDL----- 185
+ L+ ++ + +AK + + LE+ + +E + E + L S H L
Sbjct: 222 LFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ-REAETLREQLSSANHSLQLASQ 280
Query: 186 MQSAQEGQEKIE-RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSN 234
+Q A + ++ IE ++ L + K+ EI Q ++ RLQ + R N
Sbjct: 281 IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 330
Score = 33.9 bits (76), Expect = 0.19
Identities = 62/320 (19%), Positives = 125/320 (39%), Gaps = 32/320 (10%)
Query: 18 QYGERL-LQMLQK--------LPNVEGASESPSIWLLE-----KKKETEIMHQTMVQKKK 63
QY +R LQ LQ+ L N + SE L+E KK E + + + K
Sbjct: 10 QYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK 69
Query: 64 MFQRRMETLNLRWEE-----LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELK 118
FQ ++ L+ R +E L V + + + + Q +++ + E +
Sbjct: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKL 129
Query: 119 CQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYL--------EKVVENSEFEEIHE 170
+ ++E K E+ + + L K+++Y K E+ ++N E+ +
Sbjct: 130 RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
Query: 171 VIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDR 230
+ + S + Q Q +E+ + L + D+E + +E+ + +R
Sbjct: 190 LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER 249
Query: 231 A--RSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQ 288
A R+ V E+ Q ++A +L L + ++ Q + + EV L ++
Sbjct: 250 ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 309
Query: 289 LDMIQQFIQDRSDIWAEVKK 308
I Q ++D + A + K
Sbjct: 310 ---IAQLVEDVQRLQASLTK 326
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 45.4 bits (106), Expect = 6e-05
Identities = 63/301 (20%), Positives = 131/301 (43%), Gaps = 24/301 (7%)
Query: 12 AEYFRLQYGERLLQMLQKLPNV-----EGASESPSIW-----LLEKKKETEIMHQTMVQK 61
AE Y ERL + KL V + A++ +W L + +E E + + ++
Sbjct: 1257 AEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSRE 1316
Query: 62 KKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
K F R++E L + E+ ++ L +QK+++ D +R ++ +E+E+K +
Sbjct: 1317 KSNFTRQIEDLRGQLEKETKSQSALAHALQKAQR-----DCDLLR--EQYEEEQEVKAEL 1369
Query: 122 MQELTKRKQEMVALRLEHQ-RLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180
+ L+K EMV R++++ + + +D K L ++ + E + AR +L
Sbjct: 1370 HRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAA-EAMGVANARNASLER 1428
Query: 181 MRHDL---MQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIF 237
RH L + A K+ A ARL + + + + Q D ++ V
Sbjct: 1429 ARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQA 1488
Query: 238 WESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQ 297
+ ++NT + + T++ NL + +S +V E T +++ +++ I+
Sbjct: 1489 LSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLT--EMEKVKKLIE 1546
Query: 298 D 298
+
Sbjct: 1547 E 1547
Score = 37.0 bits (84), Expect = 0.023
Identities = 62/297 (20%), Positives = 121/297 (40%), Gaps = 36/297 (12%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L + KKE I Q + + R +L +L ++ + + K DQK
Sbjct: 1398 LEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQK 1457
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIF-------NKYL 156
++++ K ++ + L ++E+ AL E +L ++ + NK L
Sbjct: 1458 QLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNL 1517
Query: 157 EKVVEN------------SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQE--------KI 196
++ + N +E E++ ++I KT V + + + A E E ++
Sbjct: 1518 QEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLEL 1577
Query: 197 ERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLL- 255
AKA L R + EKD+EI N + Q D +S++ + I+ T KK +
Sbjct: 1578 LEAKAELERKLSEKDEEI---ENFRRKQQCTIDSLQSSLD--SEAKSRIEVTRLKKKMEE 1632
Query: 256 -LGTIKMATLNLFQIVSKHLKEV--TEVALEDTHKQLDMIQQFIQDRSDIWAEVKKK 309
L +++ + VS+ K + ++ ++D QLD Q D + A +++
Sbjct: 1633 DLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689
Score = 35.0 bits (79), Expect = 0.087
Identities = 31/158 (19%), Positives = 75/158 (47%), Gaps = 5/158 (3%)
Query: 82 KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVA-LRLEHQ 140
++ +L+A + + ++ +E Q+ A +KA K+ ++ ++ E K+KQ+ +A L +
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKA-KKAAIEAANLSEELKKKQDTIAHLERTRE 1796
Query: 141 RLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS-MRHDLMQSA--QEGQEKIE 197
+ + D E++ ++I ++ +R + L + ++ +SA Q G ++E
Sbjct: 1797 NMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLE 1856
Query: 198 RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
R L EE + + ++ +LQ++ + V
Sbjct: 1857 RCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV 1894
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 45.4 bits (106), Expect = 6e-05
Identities = 50/237 (21%), Positives = 107/237 (45%), Gaps = 29/237 (12%)
Query: 12 AEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMET 71
AE + + +R L+ +K+ + A E LE+ K + Q V K +RR
Sbjct: 827 AEQSKAESMQRALEEQRKVTAQQMAMERAE---LERAKSALLEEQKSVMLKCGEERRR-- 881
Query: 72 LNLRWEELGVKEAQLKAHIQK-SEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQ 130
L W E ++ K ++ +E+ +Q + Q+ + A ++ ELK + + + KQ
Sbjct: 882 LAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQ 941
Query: 131 ----------EMVALRLEHQRLSAKLKDYYIFNKYLEKV--VENSEFEEIHEVIARYKTL 178
E LRLE +R++A + + +E + V + ++EE + + +
Sbjct: 942 LAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQV 1001
Query: 179 VSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
+ + +Q+ Q+ QE++ + ++ + Q++ LA+ +++ DRAR ++
Sbjct: 1002 QAEQQARLQAVQQQQERLRK-----------QEQHMHQEHLSLAQQRLQLDRARQDL 1047
Score = 37.0 bits (84), Expect = 0.023
Identities = 34/171 (19%), Positives = 80/171 (46%), Gaps = 16/171 (9%)
Query: 65 FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE 124
+Q+R E L EEL A+ + Q++EQ E + R + +E++ + + ++E
Sbjct: 639 YQQREERLRRENEEL---SARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRE 695
Query: 125 LTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHD 184
L ++ ++ +R +H+ +L K++++ E + + ++L S+ H
Sbjct: 696 L--QRASILDMRRDHEEQLQRL-----------KLLKDREVDAATSATSHTRSLNSIIHQ 742
Query: 185 LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
+ + + E R +A +E++ I Q++ +L LQ R + + ++
Sbjct: 743 MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM 793
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 45.1 bits (105), Expect = 8e-05
Identities = 40/193 (20%), Positives = 79/193 (40%), Gaps = 26/193 (13%)
Query: 44 LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
L+ +K+ +++ ++ K+ + +E + L E G + Q +QE
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERG-------RELTTQRQLMQE---- 1708
Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
R K +K + +HM+ + + K++ V + EH +LKD
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQL-----------EQ 1757
Query: 164 EFEEIHEVIARYKTLVSMRHD----LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
+ + +H + L+S R L Q QE +E+ E + L ++E + Q++
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 220 ELARLQMRFDRAR 232
EL LQ +A+
Sbjct: 1818 ELEALQQEQQQAQ 1830
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/297 (20%), Positives = 142/297 (47%), Gaps = 54/297 (18%)
Query: 44 LLEKKKETEIMH---QTMVQKKKMFQRRMETLNL----RWEELGVKEAQL------KAHI 90
L E+++E E + Q + ++++M + +E L+L R +E+ +++ Q+ ++ +
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 91 QKSEQFIQENDQK------RIRAMKKANKERELKCQH-MQELTKRKQEMVALRLEHQRLS 143
+ +QE +QK +IR ++K + + +H + EL K+ Q + + R + Q L
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 144 AKLKDYYIFNKYLEKVVENSEFEE--IHEVIARYKTL-VSMRH---DLMQSAQEGQEK-- 195
+L LE+ E ++ I E+ + +T V++ H DL + +QE Q +
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS 1609
Query: 196 ----IERAKARLARYMEEKDDEILQQNNELARLQMR-------FDRARSNVIFWESRWAH 244
+E LAR ++E+D E+ Q ++ LQ + +R ++ + R
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 245 IQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSD 301
+++ ++T +I+ + L+++ +++L + ++L +Q +Q+R++
Sbjct: 1670 LEDQRTRQT--------------KILEEDLEQI-KLSLRERGRELTTQRQLMQERAE 1711
Score = 41.2 bits (95), Expect = 0.001
Identities = 63/320 (19%), Positives = 131/320 (40%), Gaps = 44/320 (13%)
Query: 2 SLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSI--WLLEKKKETEIMHQTMV 59
+L +E E + RL+ + ++ +Q E ++ LE +KE + +T++
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 60 QKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKC 119
Q +K + L +++ V+ K Q++ +Q Q+ R +K+A +
Sbjct: 936 QTQKELADASQQLERLRQDMKVQ----KLKEQETTGILQTQLQEAQRELKEAAR------ 985
Query: 120 QHMQELTKRKQEMVAL---RLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYK 176
QH +L ++E +L +++ Q+ LK + +++VE E++ E
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET----- 1040
Query: 177 TLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVI 236
Q Q+++ER KA L + EK+ +L + Q R ++
Sbjct: 1041 ----------QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM- 1089
Query: 237 FWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFI 296
+ + +A+ LL +K + ++ L+E+ A T +QL
Sbjct: 1090 --QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE--ASHITEQQL------- 1138
Query: 297 QDRSDIWAEVKKKEQQRVRI 316
R+ +WA+ K Q ++R+
Sbjct: 1139 --RASLWAQEAKAAQLQLRL 1156
Score = 31.6 bits (70), Expect = 0.96
Identities = 30/136 (22%), Positives = 59/136 (43%), Gaps = 28/136 (20%)
Query: 118 KCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE-----------NSEFE 166
K ++ QE +R+ +V ++L AK+ Y + + LEK +E N E
Sbjct: 41 KLKNSQEAQQRQATLV------RKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEP 94
Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQM 226
+ E++ R ++ Q+ E + +L +ME+ D ++ +L +
Sbjct: 95 NLDELLVR-----------LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTV 143
Query: 227 RFDRARSNVIFWESRW 242
+ RAR ++ ES+W
Sbjct: 144 DWSRARDELMRKESQW 159
>gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromosome
region, candidate 12 isoform b [Homo sapiens]
Length = 422
Score = 45.1 bits (105), Expect = 8e-05
Identities = 54/252 (21%), Positives = 108/252 (42%), Gaps = 14/252 (5%)
Query: 39 SPSIWLLEKKKETEI-MHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFI 97
SP L+ +++ + + M +KK ++ + R+ + + L+ I + I
Sbjct: 84 SPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKG-RFSRTNII-SDLEEQISELTAII 141
Query: 98 QENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLE 157
++ ++ A K + E +L+C M++ + K L+ H+ ++L++ Y E
Sbjct: 142 EQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNR--ELKEAHEAELSELENNYKAALKAE 199
Query: 158 KVVENSEFEEIHEVIARYKTLVSMRHDLMQSA-QEGQEKIERAKARLARYMEEKDDEILQ 216
K+ + EE+ + YK L +M S E +EK + KA+ + + + + IL
Sbjct: 200 KLAAQEKLEEMGK---EYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILL 256
Query: 217 QNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKE 276
Q + + + + ES A +N +K LL + TL L + L++
Sbjct: 257 QQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQL-----EELRK 311
Query: 277 VTEVALEDTHKQ 288
EV E+ H Q
Sbjct: 312 TKEVMQEELHAQ 323
Score = 37.4 bits (85), Expect = 0.018
Identities = 49/224 (21%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 28 QKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRR--METLNLRWEELGVKEAQ 85
Q + N E S + + ++KK E + + K F R + L + EL Q
Sbjct: 88 QLVRNREQISVTLGDEMFDRKKRWE----SEIPDKGRFSRTNIISDLEEQISELTAIIEQ 143
Query: 86 LKAHIQKSEQFIQENDQKRIRAMKK--ANKERELKCQHMQELTKRKQEM-VALRLEHQRL 142
+ Q +++ + R MK+ NK RELK H EL++ + AL+ E
Sbjct: 144 MNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAA 203
Query: 143 SAKLKDYYIFNKYLE---KVVENSEFEEIHEVIARYKT-------------LVSMRHDL- 185
KL++ KYL+ + ++S ++E+ E ++ K L+ + +
Sbjct: 204 QEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMT 263
Query: 186 ----MQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
M+S +E ++ E A +++EK++ + Q ++ +L+
Sbjct: 264 KKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE 307
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 44.7 bits (104), Expect = 1e-04
Identities = 52/231 (22%), Positives = 103/231 (44%), Gaps = 32/231 (13%)
Query: 10 DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRM 69
D E R +++++ KL +V+G + + L + + E++ + + K+++
Sbjct: 432 DQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVE---- 487
Query: 70 ETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRK 129
E+L ++E +L A ++ + DQ+ ++ ++ E + MQ+ T
Sbjct: 488 -------EQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT--- 537
Query: 130 QEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE-----NSEFEEIHEVI-ARYKTLVSMRH 183
Q+ L E Q++SA ++ + LE+ E S F++ E + A + L+ +R
Sbjct: 538 QDHAVLEAERQKMSALVRG---LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594
Query: 184 DLMQSAQEGQEKIE---------RAKARLARYMEEKDDEILQQNNELARLQ 225
+ + +E EKIE RA A R +E E+L+ EL LQ
Sbjct: 595 EKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQ 645
Score = 38.5 bits (88), Expect = 0.008
Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 16/187 (8%)
Query: 48 KKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRA 107
K+E Q + ++ +QR E L ++ A L+A QK ++ ++
Sbjct: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEET 564
Query: 108 MKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKV-VENSEFE 166
++ + + ++ ++L KQE++ LR+E + + +L EK+ V E E
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG---------EKIEVLQRELE 615
Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQE-KIERAKARLARYMEEKDDEILQQNNELARLQ 225
+ + + ++ +L+++ +E +E + ER +A +++ E +LA L+
Sbjct: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE-----KQLAVLR 670
Query: 226 MRFDRAR 232
+ DR R
Sbjct: 671 VEADRGR 677
Score = 32.7 bits (73), Expect = 0.43
Identities = 48/222 (21%), Positives = 94/222 (42%), Gaps = 43/222 (19%)
Query: 18 QYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRME-TLNLRW 76
++ R+L + Q+L G L++ + E + +Q+ + ++++E LN
Sbjct: 734 EFRRRILGLEQQLKETRG--------LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 785
Query: 77 EE---LGVKEAQLKAHIQKSEQFIQ---ENDQKRIRAMKKANKERELKCQHMQELTKRKQ 130
EE L + L+A ++++++ + + Q RA+++ K+RE+ + EL ++K
Sbjct: 786 EEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQK- 844
Query: 131 EMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQ 190
RL + D NK LEK+ E+S+ L +
Sbjct: 845 ----------RLLDRTVDR--LNKELEKIGEDSK---------------QALQQLQAQLE 877
Query: 191 EGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRAR 232
+ +EK R A R ++ E + + L+RLQ R R
Sbjct: 878 DYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,105,002
Number of Sequences: 37866
Number of extensions: 412158
Number of successful extensions: 4175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 571
Number of HSP's that attempted gapping in prelim test: 2876
Number of HSP's gapped (non-prelim): 1556
length of query: 316
length of database: 18,247,518
effective HSP length: 102
effective length of query: 214
effective length of database: 14,385,186
effective search space: 3078429804
effective search space used: 3078429804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.