Guide to the Human Genome
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Search of human proteins with 226494053

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo
sapiens]
         (316 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo sa...   619   e-177
gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo sa...   324   6e-89
gi|221554526 coiled-coil domain containing 42B [Homo sapiens]         177   1e-44
gi|217272874 coiled-coil domain containing 37 [Homo sapiens]           55   1e-07
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...    54   1e-07
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...    54   1e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     53   3e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    52   5e-07
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s...    52   5e-07
gi|148746195 trichohyalin [Homo sapiens]                               51   1e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    48   1e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    48   1e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    48   1e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    48   1e-05
gi|146260271 hypothetical protein LOC129881 [Homo sapiens]             47   2e-05
gi|226491199 coiled-coil domain containing 38 [Homo sapiens]           47   3e-05
gi|154354979 myosin X [Homo sapiens]                                   47   3e-05
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]        47   3e-05
gi|38044112 restin isoform b [Homo sapiens]                            46   4e-05
gi|4506751 restin isoform a [Homo sapiens]                             46   4e-05
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap...    46   4e-05
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]        46   5e-05
gi|124249396 coiled-coil domain containing 30 [Homo sapiens]           45   6e-05
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]              45   6e-05
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]               45   6e-05
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               45   6e-05
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]             45   6e-05
gi|21735548 centrosomal protein 2 [Homo sapiens]                       45   8e-05
gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromoso...    45   8e-05
gi|16262452 cingulin [Homo sapiens]                                    45   1e-04

>gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo
           sapiens]
          Length = 316

 Score =  619 bits (1595), Expect = e-177
 Identities = 316/316 (100%), Positives = 316/316 (100%)

Query: 1   MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
           MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ
Sbjct: 1   MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60

Query: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
           KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ
Sbjct: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120

Query: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180
           HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS
Sbjct: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180

Query: 181 MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES 240
           MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES
Sbjct: 181 MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES 240

Query: 241 RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS 300
           RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS
Sbjct: 241 RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS 300

Query: 301 DIWAEVKKKEQQRVRI 316
           DIWAEVKKKEQQRVRI
Sbjct: 301 DIWAEVKKKEQQRVRI 316


>gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo
           sapiens]
          Length = 242

 Score =  324 bits (831), Expect = 6e-89
 Identities = 164/164 (100%), Positives = 164/164 (100%)

Query: 1   MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60
           MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ
Sbjct: 1   MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ 60

Query: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120
           KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ
Sbjct: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ 120

Query: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164
           HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE
Sbjct: 121 HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164


>gi|221554526 coiled-coil domain containing 42B [Homo sapiens]
          Length = 308

 Score =  177 bits (449), Expect = 1e-44
 Identities = 107/299 (35%), Positives = 170/299 (56%), Gaps = 4/299 (1%)

Query: 13  EYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETL 72
           EYFRL   E+L     KLP        P + LLEK++E     Q +  +K++F+ +   L
Sbjct: 7   EYFRLALQEKLST---KLPEQAEDHVPPVLRLLEKRQELVDADQALQAQKEVFRTKTAAL 63

Query: 73  NLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEM 132
             RWE+L  KE +LK    + ++F+Q+++ +R RA+++A +ER    +   E  +   ++
Sbjct: 64  KQRWEQLEQKERELKGSFIRFDKFLQDSEARRNRALRRAAEERHQAGRREVEALRLWTQL 123

Query: 133 VALRLEHQRLSAKLKDYYIFNKYLEKVVENSE-FEEIHEVIARYKTLVSMRHDLMQSAQE 191
             LR EH RL  +LK      + LE+ +E    F+E+ E++AR+  L   +  L    +E
Sbjct: 124 QELRREHARLQRRLKRLEPCARLLEQALELLPGFQEVPELVARFDGLAETQAALRLRERE 183

Query: 192 GQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAK 251
              ++E A+ARL +  +   DE+L Q    A+LQ R + AR   + WES+W  IQNTAA+
Sbjct: 184 QLAELEAARARLQQLRDAWPDEVLAQGQRRAQLQERLEAARERTLQWESKWIQIQNTAAE 243

Query: 252 KTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKE 310
           KTLLLG  +MA LNLFQ+V +H  +   + +EDT  QL+ ++ F+QD S + A + + E
Sbjct: 244 KTLLLGRSRMAVLNLFQLVCQHQGQPPTLDIEDTEGQLEHVKLFMQDLSAMLAGLGQAE 302


>gi|217272874 coiled-coil domain containing 37 [Homo sapiens]
          Length = 611

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 36/198 (18%)

Query: 22  RLLQMLQKLPNVEGASESP--------SIWLL----EKKKETEIMHQTMVQKKKMFQ--- 66
           R LQ+  K  ++E  +E+         + W L    EK  E E M   + QK++MF    
Sbjct: 104 RQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQY 163

Query: 67  ---------RRMETLNLRWE-ELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERE 116
                    +R+ETL  + E  L   E  L+      ++F++END   ++AM+ A KE +
Sbjct: 164 ALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK 223

Query: 117 LKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYK 176
            K + + E+     ++V ++ E  R    LK Y ++  +L K+      EE  +      
Sbjct: 224 AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEK------ 277

Query: 177 TLVSMRHDLMQSAQEGQE 194
                +H  ++ A+E  E
Sbjct: 278 -----KHSFLKKAKEVSE 290


>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 40/279 (14%)

Query: 38   ESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI----QKS 93
            E  +I   E  K T + +Q    +K + ++ +E  +    EL   E Q    I    +K 
Sbjct: 1146 EESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKY 1205

Query: 94   EQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
            E  IQ  ++ R + +    ++RE   Q +Q+L   K E +   L+  +L  ++ +     
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDRE---QLIQKLNCEKDEAIQTALKEFKLEREVVE----K 1258

Query: 154  KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
            + LEKV      + +   IA+   + S R D      E QEK++  KA+    +EE++  
Sbjct: 1259 ELLEKV------KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEK- 1311

Query: 214  ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
              ++N E+  +                R + I         +L   KM   N+   +S  
Sbjct: 1312 --RKNEEMQNV----------------RTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353

Query: 274  LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
            LK      ++   +  D+I+   +DR+ +  E KK E++
Sbjct: 1354 LKS----TMQQQERDKDLIESLSEDRARLLEEKKKLEEE 1388


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 40/279 (14%)

Query: 38   ESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI----QKS 93
            E  +I   E  K T + +Q    +K + ++ +E  +    EL   E Q    I    +K 
Sbjct: 1146 EESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKY 1205

Query: 94   EQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
            E  IQ  ++ R + +    ++RE   Q +Q+L   K E +   L+  +L  ++ +     
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDRE---QLIQKLNCEKDEAIQTALKEFKLEREVVE----K 1258

Query: 154  KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
            + LEKV      + +   IA+   + S R D      E QEK++  KA+    +EE++  
Sbjct: 1259 ELLEKV------KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEK- 1311

Query: 214  ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
              ++N E+  +                R + I         +L   KM   N+   +S  
Sbjct: 1312 --RKNEEMQNV----------------RTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353

Query: 274  LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
            LK      ++   +  D+I+   +DR+ +  E KK E++
Sbjct: 1354 LKS----TMQQQERDKDLIESLSEDRARLLEEKKKLEEE 1388


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 53/279 (18%), Positives = 127/279 (45%), Gaps = 17/279 (6%)

Query: 50   ETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMK 109
            E E +   +  KK+  +     L  R EE   +   L+A  +K +Q IQE +++      
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957

Query: 110  KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIH 169
               K +  K     +L K ++E + L  ++ +L+ + K   + ++  E     +E EE  
Sbjct: 958  ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK--LLEDRIAEFTTNLTEEEEKS 1015

Query: 170  EVIARYK----TLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            + +A+ K     +++   + ++  ++ ++++E+ + +L     +  D+I +   ++A L+
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075

Query: 226  MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI-----VSKHLKEVTEV 280
            M+  +    +   ++  A ++  AA+K + L  I+     + ++       +  +   E 
Sbjct: 1076 MQLAKKEEEL---QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132

Query: 281  ALEDTHKQLDMIQQFIQDRSDIWA---EVKKKEQQRVRI 316
               D  ++L+ ++  ++D  D  A   E++ K +Q V I
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 46/232 (19%), Positives = 103/232 (44%), Gaps = 18/232 (7%)

Query: 5    IMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKM 64
            + EE   AE  + Q  +   ++  ++ N  G         LE+K+  E     + ++ + 
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALA----LEEKRRLEARIAQLEEELEE 1740

Query: 65   FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE 124
             Q   E +N R ++  ++  Q+   +       Q+N+  R + +++ NKE ++K Q M+ 
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR-QQLERQNKELKVKLQEMEG 1799

Query: 125  LTKRKQE--MVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
              K K +  + AL  +  +L  +L +        E     +  +++     + K ++   
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDN--------ETKERQAACKQVRRTEKKLKDVLLQV 1851

Query: 183  HDLMQSAQEGQEKIERAKARLA---RYMEEKDDEILQQNNELARLQMRFDRA 231
             D  ++A++ +++ ++A  RL    R +EE ++E  + N    +LQ   + A
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903



 Score = 35.4 bits (80), Expect = 0.067
 Identities = 53/241 (21%), Positives = 101/241 (41%), Gaps = 36/241 (14%)

Query: 9    EDLAEYFRLQYGERLLQMLQK----LPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKM 64
            E+LAE  +L+  +R+   L+K    L N  G   +    LL+ K ++E        K+K 
Sbjct: 1199 EELAE--QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE-------HKRKK 1249

Query: 65   FQRRMETLNLRWEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKEREL 117
             + +++ L +++ E       L  K  +L+  +      + ++D K  +  K  +   E 
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA-LES 1308

Query: 118  KCQHMQELTKRKQEMVALRLEHQRLSAKLK----DYYIFNKYLEKVVE-----NSEFEEI 168
            + Q  QEL + +        +   LS KLK    +   F + LE+  E       +   +
Sbjct: 1309 QLQDTQELLQEENR------QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362

Query: 169  HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRF 228
            H  +A  K  +      +++A+E + K+++    L++  EEK     +      RLQ   
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422

Query: 229  D 229
            D
Sbjct: 1423 D 1423



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 66/290 (22%), Positives = 125/290 (43%), Gaps = 25/290 (8%)

Query: 28   QKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRME--TLNLRWEELGVKEAQ 85
            QKL   +  +E+    L E++   E  +  + ++KK+ + R+   T NL  EE   ++++
Sbjct: 960  QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE---EKSK 1016

Query: 86   LKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQ--RLS 143
              A ++   + +  + ++R+R        RE K +   E T+RK E  +  L  Q   L 
Sbjct: 1017 SLAKLKNKHEAMITDLEERLR--------REEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068

Query: 144  AKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARL 203
            A++ +  +     E+ ++ +    + E  A+    +    +L     E QE +E  +A  
Sbjct: 1069 AQIAELKMQLAKKEEELQ-AALARVEEEAAQKNMALKKIRELESQISELQEDLESERA-- 1125

Query: 204  ARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMAT 263
            +R   EK    L +  E  + ++  D   S     E R    Q     K  L    K   
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELE-DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184

Query: 264  LNLFQIVSKHLKEVTEVA--LEDTHK---QLDMIQQFIQ-DRSDIWAEVK 307
              + ++  KH + V E+A  LE T +    L+  +Q ++ +R ++  EVK
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 14/193 (7%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            LL++K+  E     + ++ +  Q  ME LN R+ +  ++   L A +       Q++D  
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQ--RLSAKLKDYYIFNKYLEKVVE 161
            R + +++ NKE + K Q ++   K K +     LE +  +L  +L+          K+V 
Sbjct: 1787 R-QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845

Query: 162  NSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEILQQN 218
             +E         + K +     D  + A + +E++E+A AR   L R +EE ++E  + N
Sbjct: 1846 RTE--------KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897

Query: 219  NELARLQMRFDRA 231
                +LQ   D A
Sbjct: 1898 ASRRKLQRELDDA 1910



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 61/329 (18%), Positives = 139/329 (42%), Gaps = 46/329 (13%)

Query: 21   ERLLQMLQKLPNVEGASESPSI---WLLEKKK--------------ETEIMHQTMVQKKK 63
            E LL++ +K   VEG  E        LLE+K               E E M   +  KK+
Sbjct: 859  EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918

Query: 64   MFQRRMETLNLRWEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRA-MKKANKER 115
              +  +  L  R EE       L  ++ +++AHIQ  E+ + E +  R +  ++K   E 
Sbjct: 919  ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978

Query: 116  ELKCQHMQELTKRKQEMVALRLEHQRL--SAKLKDYYIFNKYLEKVVENSEFEEIHEVIA 173
            ++K        K ++E++ L  ++ +     KL +  I     +   E  + + + ++  
Sbjct: 979  KIK--------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 174  RYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
            + + ++S   + ++  ++ ++++E+AK +L     +  D+I +   ++  L+++  +   
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090

Query: 234  NVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI-----VSKHLKEVTEVALEDTHKQ 288
             +   +   A   +    K   L  ++     + ++       K  +   E    D  ++
Sbjct: 1091 EL---QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147

Query: 289  LDMIQQFIQDRSDIWA---EVKKKEQQRV 314
            L+ ++  ++D  D  A   E++ K +Q V
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEV 1176


>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
           sapiens]
          Length = 551

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 70/345 (20%), Positives = 145/345 (42%), Gaps = 54/345 (15%)

Query: 10  DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRM 69
           DL E  + +  + LLQ   KL  +E   E   +  +    +   +    + +K+  Q+ +
Sbjct: 164 DLEEVAK-ERAQNLLQRANKL-RMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKEL 221

Query: 70  ETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRA-------MKKANKER------- 115
           +T   R +++   E + +  IQ+ E+  ++  ++RIR        M+K  +ER       
Sbjct: 222 DTEEKRLDQM--MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQR 279

Query: 116 ------------ELKCQHMQELTKRKQEMVALRLEHQRLS-------------AKLKDYY 150
                       +L+ + ++++ +R+Q+ + ++ E +R++              KL D  
Sbjct: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQM 339

Query: 151 IFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQ-SAQEGQEKIERAKARLARYMEE 209
           +     +K+   +EFE   E I R K     R   MQ  AQ+ Q + +  +A+  R  E 
Sbjct: 340 VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAK--RNQEV 397

Query: 210 KDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQI 269
            D E  ++  E AR +M  +         E R + ++  A K+  L   ++       +I
Sbjct: 398 ADREWRRKEKENARKKMETEA--------ELRKSRLEQVAFKEHALAVQVQRDRDEFERI 449

Query: 270 VSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQRV 314
           +    +++ +  LE+  K    +Q   + R  +    +K+ Q R+
Sbjct: 450 LRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRI 494


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/239 (22%), Positives = 118/239 (49%), Gaps = 20/239 (8%)

Query: 7   EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQ 66
           EEE    + +L+  ER  Q  ++   +    E      L++++E E + Q +  ++++ +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540

Query: 67  RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQ-ENDQKRIRAMKKANKERELKCQHMQE- 124
            + E    R E+L  +E + +   ++ EQ ++ E +++R + +K+  + R+ + +  QE 
Sbjct: 541 EQEE----RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596

Query: 125 -LTKR-KQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
            L +R K+E V    + +R   +LK      +  ++++++ E EE      R + L   +
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE-----RRQQQLRREQ 651

Query: 183 HDLMQSAQEGQEKIERAKARLARYMEE--KDDEILQQNNELARLQMRFDRARSNVIFWE 239
            +  +   + +E+ ER + RL R  EE  ++ E+ ++  E AR     +R +S +  W+
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-----ERIKSRIPKWQ 705



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 48/221 (21%), Positives = 100/221 (45%), Gaps = 20/221 (9%)

Query: 7   EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQ 66
           +EE   +  R +  ER  Q L++    E   +       E+++E ++  +  +++++  +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 67  RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
           R  +   LR E+   +E QL+    + +Q  +E   +R + +++  +E   + +H QE  
Sbjct: 391 REQQ---LRREQQLRREQQLR----REQQLRREQQLRREQQLRREQEEERHEQKHEQE-- 441

Query: 127 KRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLM 186
            R+++ +    E +R   K           E+  E  E E   + + R +        L 
Sbjct: 442 -RREQRLKREQEERRDWLKR----------EEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 187 QSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMR 227
              +E +E+ ER + +L R  EE+ ++ L++  E  RLQ R
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 37/220 (16%)

Query: 45  LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGV---------KEAQLKAHIQ---- 91
           L++++ETE  H+   +K+++ + + E    RW +L           +E QL+   +    
Sbjct: 458 LKREEETE-RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516

Query: 92  ----------------KSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEM--- 132
                           +SEQ ++   ++R   + K  +E+ L+ +  ++  KR+QE    
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576

Query: 133 VALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTL--VSMRHDLMQSAQ 190
             L+ E +R   +LK      + LE+ ++  E E + +   R + L       +  Q   
Sbjct: 577 QLLKREEERRQQRLKREQ--EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634

Query: 191 EGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDR 230
           + +E+ ER + +L R  +E+ ++ L++  E  RL+ R  R
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 42/191 (21%), Positives = 84/191 (43%), Gaps = 12/191 (6%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQ-LKAHIQKSEQFIQENDQ 102
            LL +++E   + +   Q ++  + + E   L  EE   +  Q L+   +K E+  QE +Q
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092

Query: 103  K-RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE 161
              R    K+  +ERE +C+  +EL + +++++    E +R     + Y           E
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR----------E 1142

Query: 162  NSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL 221
              E ++  E + R +     R +L +  +E +E  +  +  L    E++  E  +Q  E 
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202

Query: 222  ARLQMRFDRAR 232
              LQ +  + R
Sbjct: 1203 EELQRQKRKQR 1213



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 55/257 (21%), Positives = 107/257 (41%), Gaps = 36/257 (14%)

Query: 16  RLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLR 75
           R +  ERL Q L+    +    E     LL++++E  +  +   Q+ K  Q       L+
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 76  WEE-------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ-------- 120
            EE          +E +L+  +++ E    E +++R + +K+   E E + Q        
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 121 --HMQELTKRKQEMVALRL----EHQRLSAKLKDYYIFNKYLEKVVENSE---FEEIHEV 171
               Q+L + +QE    RL    E +RL  +LK  +   +  +++ E  +    E I   
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700

Query: 172 IARYKTLVSMRHDLMQS-------AQEGQEKIERAKARLARYMEEKDDEILQQNNELARL 224
           I +++  +    D  QS        QEGQ + +  + +  R    ++ E+  Q  E A  
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR----RESELQWQEEERAHR 756

Query: 225 QMRFDRARSNVIF-WES 240
           Q + +  R +  + W++
Sbjct: 757 QQQEEEQRRDFTWQWQA 773



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 42/185 (22%), Positives = 86/185 (46%), Gaps = 11/185 (5%)

Query: 46   EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRI 105
            EK++  E+  Q   ++++  Q+  E L LR E    +  +L+   ++ E+  QE +Q   
Sbjct: 1129 EKRRRQELERQ--YREEEEVQQEEEQL-LREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 106  RAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK------LKDYYIFNKYLEKV 159
               +K  +ERE + +  +EL ++K++    R E QR   K       ++    NK   K 
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQ-RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244

Query: 160  VENSEFEEIHEVIAR-YKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQN 218
             EN +F ++ +   R  ++   ++H L +  +  +E+  R   +  R+  E++    ++ 
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 219  NELAR 223
             E  R
Sbjct: 1305 KEAKR 1309



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 53/261 (20%), Positives = 111/261 (42%), Gaps = 43/261 (16%)

Query: 3    LGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASES--------PSIWLLEKKKETEIM 54
            L  +EEE+     +LQ  ER  Q+ ++   ++   E            W  + ++E +  
Sbjct: 831  LQFLEEEE-----QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 55   HQTMVQK---KKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQF-----IQENDQKRIR 106
              T+  K   ++  ++  + L    EEL  +E + +   ++  Q+     +Q+ +++ +R
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945

Query: 107  AM--KKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSE 164
                K+  +ERE + +  ++L +++++++    E +R   + K Y           E  E
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR----------EEEE 995

Query: 165  FEEIHEVIARYKTLVSMRH---------DLMQSAQEGQEKIERAKARL-ARYMEEKDDEI 214
             ++  E + R +     R          D +Q  +E   + ER K RL  R  + +++E 
Sbjct: 996  LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055

Query: 215  LQQNNELARLQMRFDRARSNV 235
            LQQ  E    + R  R R  +
Sbjct: 1056 LQQEEEQLLGEERETRRRQEL 1076



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 42/186 (22%), Positives = 90/186 (48%), Gaps = 27/186 (14%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLK----AHIQKSEQFIQE 99
            LL++++E ++  Q   + +K  +   E   LR +E   +E QL+       ++ EQ +QE
Sbjct: 1627 LLQEREEQQLHRQE--RDRKFLE---EEPQLRRQE---REQQLRHDRDRKFREEEQLLQE 1678

Query: 100  NDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKV 159
             +++++R  ++  K RE + Q  ++  +RK      +L  Q L  K ++        E++
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE-------EQL 1731

Query: 160  VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
             + +E E++     RY+        +++  Q   E+ E+   R  R  + +++E L+Q  
Sbjct: 1732 RQETEQEQLRRQ-ERYR-------KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783

Query: 220  ELARLQ 225
            E  +L+
Sbjct: 1784 EEQQLR 1789



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 43/215 (20%), Positives = 96/215 (44%), Gaps = 42/215 (19%)

Query: 44   LLEKKKETEIMHQT----MVQKKKMFQRRMETLNLRWEELGVKEAQLKA--------HIQ 91
            LL++++E ++  Q      +++++  +R+      R +EL  +E + K           Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 92   KSEQFIQENDQKRIRAM---------KKANKERELKCQHMQELTKRKQEMVALRLEHQRL 142
            +  +F+QE  Q R +           +K  +E +L+ +  ++   R++     RLE Q+ 
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK- 1587

Query: 143  SAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI-ERAKA 201
                         + +  +  +F E  + + R +    +R +  +  +E ++ + ER + 
Sbjct: 1588 -------------VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634

Query: 202  RLARYMEEKDDEILQQNNELAR----LQMRFDRAR 232
            +L R  +E+D + L++  +L R     Q+R DR R
Sbjct: 1635 QLHR--QERDRKFLEEEPQLRRQEREQQLRHDRDR 1667



 Score = 35.0 bits (79), Expect = 0.087
 Identities = 43/213 (20%), Positives = 94/213 (44%), Gaps = 20/213 (9%)

Query: 25   QMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEA 84
            Q+L + P      E    +  E++ + E       +++K  ++  E    + +EL  +E 
Sbjct: 972  QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031

Query: 85   QL------KAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLE 138
            QL      K  +Q+ E+  +E ++ +    +   +ERE +    QEL ++ ++   L+ E
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR--RRQELERQYRKEEELQQE 1089

Query: 139  HQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIER 198
             ++L  +  +     +   +  E  E ++  E + R +     R +L +  +E +E++++
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE-EEEVQQ 1148

Query: 199  AKARLARYMEEK-----------DDEILQQNNE 220
             + +L R   EK           ++E LQQ  E
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 48/234 (20%), Positives = 97/234 (41%), Gaps = 38/234 (16%)

Query: 7   EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLL--------EKKKETEIM---- 54
           +E +LAE      GE   +  ++L   +       +W          E++ E E +    
Sbjct: 144 QERELAE------GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197

Query: 55  -HQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANK 113
            H+T     +   RR E L LR +    K+ Q +   ++ ++  QE ++K  R  +   +
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRR---ERQDRVFQEEEEKEWRKRETVLR 254

Query: 114 ERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIA 173
           + E K Q  +E  +R++E   L+ E ++L           + LE+     E +E  +   
Sbjct: 255 KEEEKLQ--EEEPQRQRE---LQEEEEQL-----------RKLERQELRRERQEEEQQQQ 298

Query: 174 RYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMR 227
           R +    +R    +  +E QE+    + R  +  E ++ ++ ++  E    Q+R
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 45/204 (22%), Positives = 93/204 (45%), Gaps = 27/204 (13%)

Query: 46  EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHI--QKSEQFIQENDQK 103
           E+++  +   Q   ++K   +R  + L+ R      +E QL+A    Q+ ++F+ E ++K
Sbjct: 760 EEEQRRDFTWQWQAEEKS--ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817

Query: 104 RIRAMKKANKERELKCQHMQELTKRKQEMVALRL-----------EHQRLSAKLKDYYIF 152
             R  ++  +E+EL  Q ++E  + ++   A +L           E +R   + +D    
Sbjct: 818 EQRRRQRREREKEL--QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD---- 871

Query: 153 NKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEE--- 209
            K+  ++ E  +    H + A+      +R +  Q  QE +E+++R +    R  E+   
Sbjct: 872 QKWRWQLEEERK-RRRHTLYAKPALQEQLRKE-QQLLQEEEEELQREEREKRRRQEQERQ 929

Query: 210 -KDDEILQQNNELARLQMRFDRAR 232
            +++E LQQ  E    + R  R R
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRR 953



 Score = 33.9 bits (76), Expect = 0.19
 Identities = 37/180 (20%), Positives = 76/180 (42%), Gaps = 13/180 (7%)

Query: 47   KKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK-RI 105
            K +E E+ HQ   Q +K  +          E   +KE Q     ++ +Q  Q+ D+K R 
Sbjct: 1361 KFREEELRHQE--QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 106  RAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEF 165
               + + +ER+ K +  ++  +R++       E Q+L  +    +   +  E++++  E 
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF---REEEQLLQEREE 1475

Query: 166  EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            +++H      K L     +     QE   K    + R     +E + + L++  +L R Q
Sbjct: 1476 QQLHRQERDRKFL---EEEQQLRRQERDRKFREQELR----SQEPERKFLEEEQQLHRQQ 1528



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 42/249 (16%), Positives = 103/249 (41%), Gaps = 24/249 (9%)

Query: 6   MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
           ++EE+      LQ  E  L+ L++   +    +         ++E ++  +   ++++  
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLER-QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 66  QRRMETLNLRWEELGVKEAQLKAHIQ--KSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
           + R E    R ++   +E QL+   +  + +Q  +E +++R     +  +E E + Q ++
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 124 ELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRH 183
              + ++E    R +  R   +L+         E+ +   +     + + R + L   R 
Sbjct: 379 REQQLRREQQLRREQQLRREQQLR--------REQQLRREQQLRREQQLRREQQL---RR 427

Query: 184 DLMQSAQEGQEKIERAKARLARYMEE------KDDEILQQNNELARLQMRFDRARSNVIF 237
           +  +   E + + ER + RL R  EE      +++E  +   E  + Q++ D+       
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER--- 484

Query: 238 WESRWAHIQ 246
              RW  ++
Sbjct: 485 -RERWLKLE 492



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 32/165 (19%), Positives = 72/165 (43%), Gaps = 10/165 (6%)

Query: 60   QKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKC 119
            ++++   R+      R EE  V+  + +    + EQ +++   ++ R  ++  +ERE + 
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477

Query: 120  QHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLV 179
             H QE  ++  E      E Q+L  + +D     + L       +F E  + + R +   
Sbjct: 1478 LHRQERDRKFLE------EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ--- 1528

Query: 180  SMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARL 224
              +   +Q  Q+ + +    + R  R  + +++E L+Q  E  +L
Sbjct: 1529 -RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572



 Score = 28.9 bits (63), Expect = 6.2
 Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 15/188 (7%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L ++++E ++  Q   ++ + F+   + +  + +E    E + +   Q+ +Q +++   +
Sbjct: 1563 LRQEREEQQLSRQ---ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619

Query: 104  RIRAMKKANKERELKCQHMQELTKR--KQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE 161
            + R  ++  +ERE +  H QE  ++  ++E    R E ++     +D     K+ E+   
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD----RKFREEEQL 1675

Query: 162  NSEFEEIHEVIARYKTLVSMRHDLMQ-SAQEGQEKIERAKARLARYMEE---KDDEILQQ 217
              E EE  + + R +     R +  Q   QE + K  + + +L R   E   +++E L+Q
Sbjct: 1676 LQEGEE--QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733

Query: 218  NNELARLQ 225
              E  +L+
Sbjct: 1734 ETEQEQLR 1741


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)

Query: 23   LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
            L + LQ    +   +E   + L  KK+E E I+H              Q   ++KKM Q+
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 68   RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
             ++      EE      L +++   +A I+K E  I   D +      K +KER+L  + 
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1007

Query: 122  MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
            + +LT       ++ + +  L+ +H+     L  +LK      + LEK+    E +  + 
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 169  HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            HE IA  +  ++   +L     + +E+++ A ARL       DDEI Q+NN L +++
Sbjct: 1068 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1114



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L ++K+  E     + ++ +  Q  ME ++ R  +   +  QL   +       Q+N+  
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
            R + +++ NKE   K   M+   K K +     LE     AK+         LE+ VE  
Sbjct: 1787 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1833

Query: 164  EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
              E+      + +   + K ++    D  + A++ +E+ E+  AR   L R +EE ++E 
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 215  LQQNNELARLQMRFDRA 231
             + N    +LQ   D A
Sbjct: 1894 QRINANRRKLQRELDEA 1910



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)

Query: 21   ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
            ++L + ++   N+E    + +I L + KK+ +    T   + + KK FQ+ +E L  ++E
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 78   ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
            E      +L+                +    Q +   ++K+ +  +   +E+ +  ++  
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 124  ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
            E  +     R++E  AL L     + L AK ++    NK L+  +E      +   + +H
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 170  EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
            E+    + L +   ++    +E ++++   E AK RL   M+      E+D +   + NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 221  LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
              R Q++           + R       AAKK  L G +K   L     +    + + + 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1646

Query: 281  ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
             L     Q+   Q+ ++D    R +I+A  K+ E++
Sbjct: 1647 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)

Query: 23   LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
            L + LQ    +   +E   + L  KK+E E I+H              Q   ++KKM Q+
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 68   RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
             ++      EE      L +++   +A I+K E  I   D +      K +KER+L  + 
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1014

Query: 122  MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
            + +LT       ++ + +  L+ +H+     L  +LK      + LEK+    E +  + 
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 169  HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            HE IA  +  ++   +L     + +E+++ A ARL       DDEI Q+NN L +++
Sbjct: 1075 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1121



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L ++K+  E     + ++ +  Q  ME ++ R  +   +  QL   +       Q+N+  
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
            R + +++ NKE   K   M+   K K +     LE     AK+         LE+ VE  
Sbjct: 1794 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1840

Query: 164  EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
              E+      + +   + K ++    D  + A++ +E+ E+  AR   L R +EE ++E 
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 215  LQQNNELARLQMRFDRA 231
             + N    +LQ   D A
Sbjct: 1901 QRINANRRKLQRELDEA 1917



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)

Query: 21   ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
            ++L + ++   N+E    + +I L + KK+ +    T   + + KK FQ+ +E L  ++E
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 78   ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
            E      +L+                +    Q +   ++K+ +  +   +E+ +  ++  
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 124  ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
            E  +     R++E  AL L     + L AK ++    NK L+  +E      +   + +H
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 170  EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
            E+    + L +   ++    +E ++++   E AK RL   M+      E+D +   + NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 221  LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
              R Q++           + R       AAKK  L G +K   L     +    + + + 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1653

Query: 281  ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
             L     Q+   Q+ ++D    R +I+A  K+ E++
Sbjct: 1654 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)

Query: 23   LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
            L + LQ    +   +E   + L  KK+E E I+H              Q   ++KKM Q+
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 68   RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
             ++      EE      L +++   +A I+K E  I   D +      K +KER+L  + 
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1014

Query: 122  MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
            + +LT       ++ + +  L+ +H+     L  +LK      + LEK+    E +  + 
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 169  HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            HE IA  +  ++   +L     + +E+++ A ARL       DDEI Q+NN L +++
Sbjct: 1075 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1121



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L ++K+  E     + ++ +  Q  ME ++ R  +   +  QL   +       Q+N+  
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
            R + +++ NKE   K   M+   K K +     LE     AK+         LE+ VE  
Sbjct: 1794 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1840

Query: 164  EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
              E+      + +   + K ++    D  + A++ +E+ E+  AR   L R +EE ++E 
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 215  LQQNNELARLQMRFDRA 231
             + N    +LQ   D A
Sbjct: 1901 QRINANRRKLQRELDEA 1917



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)

Query: 21   ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
            ++L + ++   N+E    + +I L + KK+ +    T   + + KK FQ+ +E L  ++E
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 78   ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
            E      +L+                +    Q +   ++K+ +  +   +E+ +  ++  
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 124  ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
            E  +     R++E  AL L     + L AK ++    NK L+  +E      +   + +H
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 170  EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
            E+    + L +   ++    +E ++++   E AK RL   M+      E+D +   + NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 221  LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
              R Q++           + R       AAKK  L G +K   L     +    + + + 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1653

Query: 281  ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
             L     Q+   Q+ ++D    R +I+A  K+ E++
Sbjct: 1654 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 48/237 (20%)

Query: 23   LLQMLQKLPNVEGASESPSIWLLEKKKETE-IMH--------------QTMVQKKKMFQR 67
            L + LQ    +   +E   + L  KK+E E I+H              Q   ++KKM Q+
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 68   RMETLNLRWEE------LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
             ++      EE      L +++   +A I+K E  I   D +      K +KER+L  + 
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN----NKLSKERKLLEER 1007

Query: 122  MQELT-------KRKQEMVALRLEHQ----RLSAKLKDYYIFNKYLEKVVENSEFE--EI 168
            + +LT       ++ + +  L+ +H+     L  +LK      + LEK+    E +  + 
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 169  HEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            HE IA  +  ++   +L     + +E+++ A ARL       DDEI Q+NN L +++
Sbjct: 1068 HEQIADLQAQIA---ELKMQLAKKEEELQAALARL-------DDEIAQKNNALKKIR 1114



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 22/197 (11%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L ++K+  E     + ++ +  Q  ME ++ R  +   +  QL   +       Q+N+  
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
            R + +++ NKE   K   M+   K K +     LE     AK+         LE+ VE  
Sbjct: 1787 R-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQ-------LEEQVEQE 1833

Query: 164  EFEE------IHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKAR---LARYMEEKDDEI 214
              E+      + +   + K ++    D  + A++ +E+ E+  AR   L R +EE ++E 
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 215  LQQNNELARLQMRFDRA 231
             + N    +LQ   D A
Sbjct: 1894 QRINANRRKLQRELDEA 1910



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 67/336 (19%), Positives = 140/336 (41%), Gaps = 48/336 (14%)

Query: 21   ERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQT---MVQKKKMFQRRMETLNLRWE 77
            ++L + ++   N+E    + +I L + KK+ +    T   + + KK FQ+ +E L  ++E
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 78   ELGVKEAQLK--------------AHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQ 123
            E      +L+                +    Q +   ++K+ +  +   +E+ +  ++  
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 124  ELTK-----RKQEMVALRLE---HQRLSAKLKDYYIFNKYLEKVVE------NSEFEEIH 169
            E  +     R++E  AL L     + L AK ++    NK L+  +E      +   + +H
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 170  EVIARYKTLVSMRHDLMQSAQEGQEKI---ERAKARLARYME------EKDDEILQQNNE 220
            E+    + L +   ++    +E ++++   E AK RL   M+      E+D +   + NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 221  LARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEV 280
              R Q++           + R       AAKK  L G +K   L     +    + + + 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKK-LEGDLKDLELQADSAIKGREEAIKQ- 1646

Query: 281  ALEDTHKQLDMIQQFIQD----RSDIWAEVKKKEQQ 312
             L     Q+   Q+ ++D    R +I+A  K+ E++
Sbjct: 1647 -LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681


>gi|146260271 hypothetical protein LOC129881 [Homo sapiens]
          Length = 552

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 61/262 (23%), Positives = 113/262 (43%), Gaps = 28/262 (10%)

Query: 8   EEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQR 67
           EED   Y  L   +  LQ +  +P+ E      S+  L +  E   +      KK+M  R
Sbjct: 28  EEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTR--EAACLRAERKAKKEMHLR 85

Query: 68  RMETLNLRWEEL--GVKEAQLKAHIQKSEQFIQEND-----------QKRIRAMKKANKE 114
             E +   W     G+KE +L+A  ++ E+   E              KR +A++ A + 
Sbjct: 86  SQEVVK-HWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQY 144

Query: 115 R-----ELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIH 169
           +      +K  H   L  R  +    ++E ++  +K+K    + + L+  +E +  EE  
Sbjct: 145 QFYQTERVKNFHSGLLLSRVMKERDAQIEFRK--SKIKSDKKWEEQLKLNIEKAFKEEQE 202

Query: 170 EVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFD 229
           +   R++  V++  D ++  +E +E+ ER K       EEKD E +++ N L  ++MR  
Sbjct: 203 KAEKRHRERVALAKDHLKQIKEHEEEEERRKK-----YEEKDAEEIKRQNALYEIEMRKK 257

Query: 230 RARSNVIFWESRWAHIQNTAAK 251
             +      ESR   +++   K
Sbjct: 258 LEKKREEMHESRRRFLEHMQDK 279



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 31/222 (13%)

Query: 7   EEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETE---IMHQTMVQKKK 63
           +EE  AE   L   E + +  ++   +E A +    +  E+ K      ++ + M ++  
Sbjct: 112 DEEIEAERQILDLEEEIYKQGKRKKAIENAKQY-QFYQTERVKNFHSGLLLSRVMKERDA 170

Query: 64  MFQRRMETL--NLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIR---AMKKANKERELK 118
             + R   +  + +WEE      QLK +I+K+ +  QE  +KR R   A+ K + ++  +
Sbjct: 171 QIEFRKSKIKSDKKWEE------QLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKE 224

Query: 119 CQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTL 178
            +  +E  K+ +E  A  ++ Q    +++      K LEK     + EE+HE   R+   
Sbjct: 225 HEEEEERRKKYEEKDAEEIKRQNALYEIE----MRKKLEK-----KREEMHESRRRFLEH 275

Query: 179 VSMRHDLMQSAQEGQE-------KIERAKARLARYMEEKDDE 213
           +  +H +    Q+ QE       K  +AK RL +  +EK+ E
Sbjct: 276 MQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAE 317


>gi|226491199 coiled-coil domain containing 38 [Homo sapiens]
          Length = 563

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 28/125 (22%), Positives = 63/125 (50%), Gaps = 1/125 (0%)

Query: 33  VEGASESPSIW-LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQ 91
           +EG+    ++   +  +++  ++   +  K+   ++  + + +R  +L   E +L+    
Sbjct: 100 IEGSDTKRTVHEFINDQRDRFLLEYALSTKRNTIKKFEKDIAMRERQLKKAEKKLQDDAL 159

Query: 92  KSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYI 151
             E+F++ENDQ+ + A+K A +E   K Q   EL K   E+ A++ E  +    L++Y  
Sbjct: 160 AFEEFLRENDQRSVDALKMAAQETINKLQMTAELKKASMEVQAVKSEIAKTEFLLREYMK 219

Query: 152 FNKYL 156
           +  +L
Sbjct: 220 YGFFL 224


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%)

Query: 45  LEKKKETEIMHQTMV------------QKKKMF------QRRMETLNLRWEELGVKEA-- 84
           LEK++E E+ H  MV            Q +K+       Q+      LR   L +K+A  
Sbjct: 734 LEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAI 793

Query: 85  ----QLKAHI-------------QKSEQFIQENDQKRIRAMKKANKERE-----LKCQHM 122
               QL+  I             ++ E+  QE ++K+ R  ++  +ERE     L+ Q  
Sbjct: 794 VFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQE 853

Query: 123 QELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMR 182
           +E T+++QE+ AL+   +             + LEK  EN + EEI  +    + L  M+
Sbjct: 854 EE-TRKQQELEALQKSQKEAE--------LTRELEKQKENKQVEEILRLEKEIEDLQRMK 904

Query: 183 HDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRF 228
                     Q+++   +A L +  E +D E+ +   E  R    F
Sbjct: 905 E---------QQELSLTEASLQKLQERRDQELRRLEEEACRAAQEF 941


>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
          Length = 841

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 38/141 (26%), Positives = 69/141 (48%), Gaps = 7/141 (4%)

Query: 85  QLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSA 144
           QL+   Q+ EQ  QE  + R  A K+     EL  + +QE ++ K+E+ A+RL H++   
Sbjct: 404 QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL 463

Query: 145 KLKDYYIFNKYLEKVVENS--EFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI---ERA 199
            ++  Y   + L ++ E+   + EE+   I   K        L Q+ +E Q ++   + A
Sbjct: 464 GVRARY--ERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 521

Query: 200 KARLARYMEEKDDEILQQNNE 220
           K    R ++E ++ + QQ  E
Sbjct: 522 KGWFERRLKEAEESLQQQQQE 542



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 69/327 (21%), Positives = 129/327 (39%), Gaps = 73/327 (22%)

Query: 6   MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
           +E    AE  RLQ  E L ++ +KL                 KK+ E   +   +K+ +F
Sbjct: 213 LESSKQAETSRLQ--EELAKLSEKL-----------------KKKQESFCRLQTEKETLF 253

Query: 66  ---QRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQE-----------NDQKRIRAMKKA 111
              + ++E L  R      KEA  KA + ++++  QE            DQ++   ++ A
Sbjct: 254 NDSRNKIEELQQR------KEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 307

Query: 112 NKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN----KYLEKVVENSE--F 165
              R L+ Q   +    ++++  L  E+  L   L           + L  + E +    
Sbjct: 308 AALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLA 367

Query: 166 EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            E+ +  A Y+ L+  + DL    QE      RA +RL   ++E   E  Q   EL    
Sbjct: 368 AELQQQQAEYEDLMGQKDDLNSQLQESL----RANSRLLEQLQEIGQEKEQLTQEL---- 419

Query: 226 MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDT 285
                               + +A K+  +L  + M TL   Q  S+H +E+  V L   
Sbjct: 420 -----------------QEARKSAEKRKAMLDELAMETL---QEKSQHKEELGAVRLRHE 459

Query: 286 HKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
            + L +  ++ ++  ++  + K++E++
Sbjct: 460 KEVLGVRARYERELRELHEDKKRQEEE 486



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 24/100 (24%), Positives = 50/100 (50%), Gaps = 13/100 (13%)

Query: 44  LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK-------EAQLKAHIQKSEQF 96
           L E KK  E   +  ++++K   R +ETL    EEL  +       +   +  ++++E+ 
Sbjct: 476 LHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEES 535

Query: 97  IQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALR 136
           +Q+  Q++  A+K+  +      QH  EL  +++E+  +R
Sbjct: 536 LQQQQQEQEEALKQCRE------QHAAELKGKEEELQDVR 569


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 29/209 (13%)

Query: 45   LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK--------EAQLKAHIQKSEQF 96
            LEKK ET   H    + K  ++R       + EE+           E +LK   +++   
Sbjct: 965  LEKKMETS--HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022

Query: 97   IQENDQKRIRAMK-KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK---------- 145
            +QE ++ R +A K KA +  E   Q M+++TK K E +A   + ++ +AK          
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082

Query: 146  --LKDYYIFNKYLEKV-VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQ----EKIER 198
              LK+    NK  E + VEN + EE  + I   K   + +   + + QE      E++ R
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142

Query: 199  AKARLARYMEEKDDEILQQNNELARLQMR 227
            ++  +  + ++ ++E    NN+L  ++ R
Sbjct: 1143 SRDEVTSH-QKLEEERSVLNNQLLEMKKR 1170



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 37/239 (15%)

Query: 21   ERLLQMLQKL-----PNVEGASESPSIWLLE---------KKKETEIMHQTMVQKKKMFQ 66
            E +LQ LQK        ++GA E  S  L E         K K  +     M   ++M +
Sbjct: 995  EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054

Query: 67   RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
             + ETL    +       Q  A +Q     ++EN+ K +  + K+ +   ++ Q M+E  
Sbjct: 1055 EKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109

Query: 127  K-----------RKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARY 175
            K           + Q++ AL+ E+ +L+ +L       +  ++V  + + EE   V+   
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEEL------GRSRDEVTSHQKLEEERSVLNNQ 1163

Query: 176  KTLVSMRHD-LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
               +  R    ++ A E +  ++++ +  +  + EKD E+ +  NE+  L+     A+S
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 55/287 (19%), Positives = 123/287 (42%), Gaps = 34/287 (11%)

Query: 48  KKETEIMHQTMVQKKKM--FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK-- 103
           +++ E+++Q   +K+K+   Q R+E  ++   +L V     K+ I + E+ +    Q+  
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481

Query: 104 RIRAMKKANK---ERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDY----------- 149
            +R   ++NK   + ++    +QE++  ++++   R +HQR    LK++           
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541

Query: 150 ----YIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLAR 205
               Y   + L K  E+ + +  H        +   +  L  +    Q+ +E  K   ++
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601

Query: 206 YMEEKDDEILQQNNELARLQMRFDRARSNVIFWE--SRWAHIQNTAAKKTLLLGTIKMAT 263
            +  +  E  +   ++ ++++ +     N+   +   R AH +   A +  L+  IK   
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661

Query: 264 LNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKE 310
            +L  I SK L +  +  L +    L+ +Q+         AE+K KE
Sbjct: 662 NSLEAIRSK-LDKAEDQHLVEMEDTLNKLQE---------AEIKVKE 698



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 43/202 (21%), Positives = 88/202 (43%), Gaps = 32/202 (15%)

Query: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQEN-DQKRIRAMKKANKERELKC 119
           +K   + + E   LR ++L   E Q+K H++     I++N +  +  ++ +  + RELK 
Sbjct: 734 RKASSEGKSEMKKLR-QQLEAAEKQIK-HLE-----IEKNAESSKASSITRELQGRELKL 786

Query: 120 QHMQE-LTKRKQEMVALRLEHQRLSAKLKD------------YYIFNKYLEKVVE----N 162
            ++QE L++  Q    L  E Q L  K  +                NK  +K  +    +
Sbjct: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846

Query: 163 SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL- 221
           S+ E++ E +A  +     + +  +   + +EK+E   A + +   +   ++ + N+EL 
Sbjct: 847 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 906

Query: 222 ------ARLQMRFDRARSNVIF 237
                   LQ++  +A  N  F
Sbjct: 907 LKERDVEELQLKLTKANENASF 928


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 29/209 (13%)

Query: 45   LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVK--------EAQLKAHIQKSEQF 96
            LEKK ET   H    + K  ++R       + EE+           E +LK   +++   
Sbjct: 1000 LEKKMETS--HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057

Query: 97   IQENDQKRIRAMK-KANKERELKCQHMQELTKRKQEMVALRLEHQRLSAK---------- 145
            +QE ++ R +A K KA +  E   Q M+++TK K E +A   + ++ +AK          
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117

Query: 146  --LKDYYIFNKYLEKV-VENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQ----EKIER 198
              LK+    NK  E + VEN + EE  + I   K   + +   + + QE      E++ R
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177

Query: 199  AKARLARYMEEKDDEILQQNNELARLQMR 227
            ++  +  + ++ ++E    NN+L  ++ R
Sbjct: 1178 SRDEVTSH-QKLEEERSVLNNQLLEMKKR 1205



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 37/239 (15%)

Query: 21   ERLLQMLQKL-----PNVEGASESPSIWLLE---------KKKETEIMHQTMVQKKKMFQ 66
            E +LQ LQK        ++GA E  S  L E         K K  +     M   ++M +
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089

Query: 67   RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELT 126
             + ETL    +       Q  A +Q     ++EN+ K +  + K+ +   ++ Q M+E  
Sbjct: 1090 EKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144

Query: 127  K-----------RKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARY 175
            K           + Q++ AL+ E+ +L+ +L       +  ++V  + + EE   V+   
Sbjct: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEEL------GRSRDEVTSHQKLEEERSVLNNQ 1198

Query: 176  KTLVSMRHD-LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARS 233
               +  R    ++ A E +  ++++ +  +  + EKD E+ +  NE+  L+     A+S
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 58/326 (17%), Positives = 140/326 (42%), Gaps = 35/326 (10%)

Query: 10  DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTM--VQKKKMFQR 67
           + A+  +++   +L +  +K+ +++   E  SI   + + +T++ H  +  +++  +F++
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477

Query: 68  -RMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK--RIRAMKKANK---ERELKCQH 121
            + + L    E+  V     K+ I + E+ +    Q+   +R   ++NK   + ++    
Sbjct: 478 TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 537

Query: 122 MQELTKRKQEMVALRLEHQRLSAKLKDY---------------YIFNKYLEKVVENSEFE 166
           +QE++  ++++   R +HQR    LK++               Y   + L K  E+ + +
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 597

Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQM 226
             H        +   +  L  +    Q+ +E  K   ++ +  +  E  +   ++ ++++
Sbjct: 598 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL 657

Query: 227 RFDRARSNVIFWE--SRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALED 284
            +     N+   +   R AH +   A +  L+  IK    +L  I SK L +  +  L +
Sbjct: 658 DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK-LDKAEDQHLVE 716

Query: 285 THKQLDMIQQFIQDRSDIWAEVKKKE 310
               L+ +Q+         AE+K KE
Sbjct: 717 MEDTLNKLQE---------AEIKVKE 733



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 43/202 (21%), Positives = 88/202 (43%), Gaps = 32/202 (15%)

Query: 61  KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQEN-DQKRIRAMKKANKERELKC 119
           +K   + + E   LR ++L   E Q+K H++     I++N +  +  ++ +  + RELK 
Sbjct: 769 RKASSEGKSEMKKLR-QQLEAAEKQIK-HLE-----IEKNAESSKASSITRELQGRELKL 821

Query: 120 QHMQE-LTKRKQEMVALRLEHQRLSAKLKD------------YYIFNKYLEKVVE----N 162
            ++QE L++  Q    L  E Q L  K  +                NK  +K  +    +
Sbjct: 822 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 881

Query: 163 SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNEL- 221
           S+ E++ E +A  +     + +  +   + +EK+E   A + +   +   ++ + N+EL 
Sbjct: 882 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 941

Query: 222 ------ARLQMRFDRARSNVIF 237
                   LQ++  +A  N  F
Sbjct: 942 LKERDVEELQLKLTKANENASF 963


>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
           sapiens]
          Length = 955

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 54/284 (19%), Positives = 118/284 (41%), Gaps = 22/284 (7%)

Query: 45  LEKKKET---------EIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQ 95
           LEKK +T         E     + + KK+ ++  E+LN  WE+   K     A +++ + 
Sbjct: 315 LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEK---KLHNAVAEMEQEKF 371

Query: 96  FIQENDQKRIRAMKKANKER--ELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN 153
            +Q+   + I+ + +    R  +++ ++M +       +  L    Q+L+ + ++  +  
Sbjct: 372 DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQR 431

Query: 154 KYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDE 213
           + L  + E +E E  +++       V  R + +   ++          +L +   + D  
Sbjct: 432 QKL--IQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489

Query: 214 ILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKH 273
           +L+Q + L+       +A S +   E     ++    +  L          N FQ+   H
Sbjct: 490 LLKQEHALSA-----SKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544

Query: 274 LKEVTEVALEDTHKQLDMIQQFIQDRSDIWAE-VKKKEQQRVRI 316
           LK + E    D   +LD  ++  Q +   + E +K+KE+Q  R+
Sbjct: 545 LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV 588



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 35/180 (19%), Positives = 81/180 (45%), Gaps = 18/180 (10%)

Query: 52  EIMHQTMVQKKKMFQ----RRMETLNLRWEELGVKEAQLKAHIQKSEQFIQ-------EN 100
           E + Q + Q K+  Q    +R + L  +  +  ++++ LK   +K    +Q       E+
Sbjct: 507 EELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKED 566

Query: 101 DQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVV 160
            QK+I   ++A KE+E +   + E+ + + +     LE  +   +L    ++ +  E   
Sbjct: 567 TQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKE--- 623

Query: 161 ENSEFEEIHEVIARYKTL-VSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
              + E++   + R K+L      + +   ++ +++ E+    L    E++   +LQQ+N
Sbjct: 624 ---QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHN 680


>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
          Length = 625

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 54/229 (23%), Positives = 102/229 (44%), Gaps = 39/229 (17%)

Query: 85  QLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSA 144
           QL+   Q+ EQ  QE  + R  A K+     EL  + +QE ++ K+E+ A+RL H++   
Sbjct: 351 QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL 410

Query: 145 KLKDYYIFNKYLEKVVENS--EFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKI---ERA 199
            ++  Y   + L ++ E+   + EE+   I   K        L Q+ +E Q ++   + A
Sbjct: 411 GVRARY--ERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 468

Query: 200 KARLARYMEE---KDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLL 256
           K    R ++E   K++E+    ++L + Q             E R  H++  ++ K  + 
Sbjct: 469 KGWFERRLKEAEGKEEELQDVRDQLEQAQ-------------EERDCHLKTISSLKQEVK 515

Query: 257 GTIKMATLNLFQIVSKHLKEVTEVALEDTHKQL-------DMIQQFIQD 298
            T+    +         L++    AL+D  +QL       D +Q+ +QD
Sbjct: 516 DTVDGQRI---------LEKKGSAALKDLKRQLHLERKRADKLQERLQD 555



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 69/327 (21%), Positives = 129/327 (39%), Gaps = 73/327 (22%)

Query: 6   MEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMF 65
           +E    AE  RLQ  E L ++ +KL                 KK+ E   +   +K+ +F
Sbjct: 160 LESSKQAETSRLQ--EELAKLSEKL-----------------KKKQESFCRLQTEKETLF 200

Query: 66  ---QRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQE-----------NDQKRIRAMKKA 111
              + ++E L  R      KEA  KA + ++++  QE            DQ++   ++ A
Sbjct: 201 NDSRNKIEELQQR------KEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 254

Query: 112 NKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFN----KYLEKVVENSE--F 165
              R L+ Q   +    ++++  L  E+  L   L           + L  + E +    
Sbjct: 255 AALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLA 314

Query: 166 EEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
            E+ +  A Y+ L+  + DL    QE      RA +RL   ++E   E  Q   EL    
Sbjct: 315 AELQQQQAEYEDLMGQKDDLNSQLQESL----RANSRLLEQLQEIGQEKEQLTQEL---- 366

Query: 226 MRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDT 285
                               + +A K+  +L  + M TL   Q  S+H +E+  V L   
Sbjct: 367 -----------------QEARKSAEKRKAMLDELAMETL---QEKSQHKEELGAVRLRHE 406

Query: 286 HKQLDMIQQFIQDRSDIWAEVKKKEQQ 312
            + L +  ++ ++  ++  + K++E++
Sbjct: 407 KEVLGVRARYERELRELHEDKKRQEEE 433



 Score = 31.6 bits (70), Expect = 0.96
 Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 23/120 (19%)

Query: 44  LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEEL-----------GVKEAQLKAHIQK 92
           L E KK  E   +  ++++K   R +ETL    EEL           G  E +LK    K
Sbjct: 423 LHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGK 482

Query: 93  SEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMV----ALRLEHQRLSAKLKD 148
            E+     DQ     +++A +ER+    H++ ++  KQE+       R+  ++ SA LKD
Sbjct: 483 EEELQDVRDQ-----LEQAQEERDC---HLKTISSLKQEVKDTVDGQRILEKKGSAALKD 534


>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
          Length = 783

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 53/254 (20%), Positives = 118/254 (46%), Gaps = 33/254 (12%)

Query: 46  EKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKE-------AQLKAHIQKSEQFIQ 98
           + + + +  +Q   QK+K+  + ++ L+ +   L  KE       +Q ++ IQ+ E  ++
Sbjct: 391 QNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLK 450

Query: 99  --ENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYL 156
             EN++++     K+N+E        ++L+K +QE  ALR E+ RL  KL + ++ N Y 
Sbjct: 451 QLENEKRKYDEHVKSNQELS------EKLSKLQQEKEALREEYLRL-LKLLNVHVRN-YN 502

Query: 157 EKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEG----QEKIERAKARLARYMEEKD- 211
           EK   + +  ++ +V  R    V +R   +   ++     Q KIE+ KA   +   + D 
Sbjct: 503 EK--HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDT 560

Query: 212 ---------DEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMA 262
                    +++++Q   +   +      +S V++ +     +Q  + + T  +G ++  
Sbjct: 561 LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERI 620

Query: 263 TLNLFQIVSKHLKE 276
             ++     ++LKE
Sbjct: 621 IRSIHIRRGENLKE 634


>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
          Length = 1505

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 56/230 (24%), Positives = 107/230 (46%), Gaps = 17/230 (7%)

Query: 17  LQYGERLLQMLQKLPNVEGASESPSIWLLEKKKE-TEIMHQTMVQK--KKMFQRRMETLN 73
           L  G++L   +Q+L ++E  ++     L E  KE  E+ +Q +  K  K+  +   +TL 
Sbjct: 95  LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK 154

Query: 74  LRWEELGV-KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE-LTKRKQE 131
            + E + + KE +L+    + E+ +QE        +++A    E K Q +Q  L K + E
Sbjct: 155 NQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEA----EHKVQSLQTALEKTRTE 210

Query: 132 MVALRLEH-QRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDL----- 185
           +  L+ ++ +  +AK  +  +    LE+  + +E  +  E     + L S  H L     
Sbjct: 211 LFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ-REAETLREQLSSANHSLQLASQ 269

Query: 186 MQSAQEGQEKIE-RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSN 234
           +Q A + ++ IE   ++ L   +  K+ EI Q   ++ RLQ    + R N
Sbjct: 270 IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319



 Score = 32.0 bits (71), Expect = 0.74
 Identities = 55/299 (18%), Positives = 116/299 (38%), Gaps = 23/299 (7%)

Query: 30  LPNVEGASESPSIWLLE-----KKKETEIMHQTMVQKKKMFQRRMETLNLRWEE-----L 79
           L N +  SE     L+E     KK   E + + +    K FQ  ++ L+ R +E     L
Sbjct: 20  LANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL 79

Query: 80  GVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEH 139
            V +  +          + +  Q +++ +     E +   + ++E  K   E+    +  
Sbjct: 80  NVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTI 139

Query: 140 QRLSAKLKDYYIFNKYL--------EKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQE 191
           + L  K+++Y    K          E+ ++N   E+  ++     +  S   +     Q 
Sbjct: 140 KALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQS 199

Query: 192 GQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRA--RSNVIFWESRWAHIQNTA 249
            Q  +E+ +  L     + D+E   + +E+  +    +RA  R+ V   E+     Q ++
Sbjct: 200 LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS 259

Query: 250 AKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKK 308
           A  +L L +      ++ Q +    +   EV L    ++   I Q ++D   + A + K
Sbjct: 260 ANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE---IAQLVEDVQRLQASLTK 315


>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
          Length = 678

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 56/230 (24%), Positives = 107/230 (46%), Gaps = 17/230 (7%)

Query: 17  LQYGERLLQMLQKLPNVEGASESPSIWLLEKKKE-TEIMHQTMVQK--KKMFQRRMETLN 73
           L  G++L   +Q+L ++E  ++     L E  KE  E+ +Q +  K  K+  +   +TL 
Sbjct: 106 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK 165

Query: 74  LRWEELGV-KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE-LTKRKQE 131
            + E + + KE +L+    + E+ +QE        +++A    E K Q +Q  L K + E
Sbjct: 166 NQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEA----EHKVQSLQTALEKTRTE 221

Query: 132 MVALRLEH-QRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDL----- 185
           +  L+ ++ +  +AK  +  +    LE+  + +E  +  E     + L S  H L     
Sbjct: 222 LFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ-REAETLREQLSSANHSLQLASQ 280

Query: 186 MQSAQEGQEKIE-RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSN 234
           +Q A + ++ IE   ++ L   +  K+ EI Q   ++ RLQ    + R N
Sbjct: 281 IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 330



 Score = 33.9 bits (76), Expect = 0.19
 Identities = 62/320 (19%), Positives = 125/320 (39%), Gaps = 32/320 (10%)

Query: 18  QYGERL-LQMLQK--------LPNVEGASESPSIWLLE-----KKKETEIMHQTMVQKKK 63
           QY +R  LQ LQ+        L N +  SE     L+E     KK   E + + +    K
Sbjct: 10  QYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK 69

Query: 64  MFQRRMETLNLRWEE-----LGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELK 118
            FQ  ++ L+ R +E     L V +  +          + +  Q +++ +     E +  
Sbjct: 70  SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKL 129

Query: 119 CQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYL--------EKVVENSEFEEIHE 170
            + ++E  K   E+    +  + L  K+++Y    K          E+ ++N   E+  +
Sbjct: 130 RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 189

Query: 171 VIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDR 230
           +     +  S   +     Q  Q  +E+ +  L     + D+E   + +E+  +    +R
Sbjct: 190 LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER 249

Query: 231 A--RSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQ 288
           A  R+ V   E+     Q ++A  +L L +      ++ Q +    +   EV L    ++
Sbjct: 250 ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 309

Query: 289 LDMIQQFIQDRSDIWAEVKK 308
              I Q ++D   + A + K
Sbjct: 310 ---IAQLVEDVQRLQASLTK 326


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 63/301 (20%), Positives = 131/301 (43%), Gaps = 24/301 (7%)

Query: 12   AEYFRLQYGERLLQMLQKLPNV-----EGASESPSIW-----LLEKKKETEIMHQTMVQK 61
            AE     Y ERL +   KL  V     + A++   +W      L + +E E +   + ++
Sbjct: 1257 AEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSRE 1316

Query: 62   KKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQH 121
            K  F R++E L  + E+    ++ L   +QK+++     D   +R  ++  +E+E+K + 
Sbjct: 1317 KSNFTRQIEDLRGQLEKETKSQSALAHALQKAQR-----DCDLLR--EQYEEEQEVKAEL 1369

Query: 122  MQELTKRKQEMVALRLEHQ-RLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS 180
             + L+K   EMV  R++++  +  + +D     K L   ++ +  E +    AR  +L  
Sbjct: 1370 HRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAA-EAMGVANARNASLER 1428

Query: 181  MRHDL---MQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIF 237
             RH L   +  A     K+  A ARL +   +    +     +    Q   D ++  V  
Sbjct: 1429 ARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQA 1488

Query: 238  WESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQ 297
              +    ++NT  +  +   T++    NL + +S    +V E     T  +++ +++ I+
Sbjct: 1489 LSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLT--EMEKVKKLIE 1546

Query: 298  D 298
            +
Sbjct: 1547 E 1547



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 62/297 (20%), Positives = 121/297 (40%), Gaps = 36/297 (12%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L + KKE  I  Q   +   +   R  +L     +L ++     + + K        DQK
Sbjct: 1398 LEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQK 1457

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIF-------NKYL 156
            ++++ K     ++   +    L   ++E+ AL  E  +L    ++  +        NK L
Sbjct: 1458 QLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNL 1517

Query: 157  EKVVEN------------SEFEEIHEVIARYKTLVSMRHDLMQSAQEGQE--------KI 196
            ++ + N            +E E++ ++I   KT V +  +  + A E  E        ++
Sbjct: 1518 QEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLEL 1577

Query: 197  ERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLL- 255
              AKA L R + EKD+EI    N   + Q   D  +S++       + I+ T  KK +  
Sbjct: 1578 LEAKAELERKLSEKDEEI---ENFRRKQQCTIDSLQSSLD--SEAKSRIEVTRLKKKMEE 1632

Query: 256  -LGTIKMATLNLFQIVSKHLKEV--TEVALEDTHKQLDMIQQFIQDRSDIWAEVKKK 309
             L  +++      + VS+  K +   ++ ++D   QLD   Q   D  +  A  +++
Sbjct: 1633 DLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689



 Score = 35.0 bits (79), Expect = 0.087
 Identities = 31/158 (19%), Positives = 75/158 (47%), Gaps = 5/158 (3%)

Query: 82   KEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVA-LRLEHQ 140
            ++ +L+A + + ++  +E  Q+   A +KA K+  ++  ++ E  K+KQ+ +A L    +
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKA-KKAAIEAANLSEELKKKQDTIAHLERTRE 1796

Query: 141  RLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS-MRHDLMQSA--QEGQEKIE 197
             +   + D        E++      ++I ++ +R + L   +  ++ +SA  Q G  ++E
Sbjct: 1797 NMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLE 1856

Query: 198  RAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
            R    L    EE    + +   ++ +LQ++    +  V
Sbjct: 1857 RCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV 1894


>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 50/237 (21%), Positives = 107/237 (45%), Gaps = 29/237 (12%)

Query: 12   AEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMET 71
            AE  + +  +R L+  +K+   + A E      LE+ K   +  Q  V  K   +RR   
Sbjct: 827  AEQSKAESMQRALEEQRKVTAQQMAMERAE---LERAKSALLEEQKSVMLKCGEERRR-- 881

Query: 72   LNLRWEELGVKEAQLKAHIQK-SEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQ 130
            L   W E   ++   K   ++ +E+ +Q + Q+    +  A ++ ELK +  +   + KQ
Sbjct: 882  LAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQ 941

Query: 131  ----------EMVALRLEHQRLSAKLKDYYIFNKYLEKV--VENSEFEEIHEVIARYKTL 178
                      E   LRLE +R++A      +  + +E +  V + ++EE    +   + +
Sbjct: 942  LAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQV 1001

Query: 179  VSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
             + +   +Q+ Q+ QE++ +           ++  + Q++  LA+ +++ DRAR ++
Sbjct: 1002 QAEQQARLQAVQQQQERLRK-----------QEQHMHQEHLSLAQQRLQLDRARQDL 1047



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 34/171 (19%), Positives = 80/171 (46%), Gaps = 16/171 (9%)

Query: 65  FQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQE 124
           +Q+R E L    EEL    A+  +  Q++EQ   E   +  R +    +E++ + + ++E
Sbjct: 639 YQQREERLRRENEEL---SARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRE 695

Query: 125 LTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHD 184
           L  ++  ++ +R +H+    +L           K++++ E +      +  ++L S+ H 
Sbjct: 696 L--QRASILDMRRDHEEQLQRL-----------KLLKDREVDAATSATSHTRSLNSIIHQ 742

Query: 185 LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNV 235
           + + +    E   R +A      +E++  I Q++ +L  LQ R  + + ++
Sbjct: 743 MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM 793


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 40/193 (20%), Positives = 79/193 (40%), Gaps = 26/193 (13%)

Query: 44   LLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQK 103
            L+ +K+  +++     ++ K+ +  +E + L   E G         +    Q +QE    
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERG-------RELTTQRQLMQE---- 1708

Query: 104  RIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENS 163
            R    K  +K +    +HM+ + + K++ V  + EH     +LKD               
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQL-----------EQ 1757

Query: 164  EFEEIHEVIARYKTLVSMRHD----LMQSAQEGQEKIERAKARLARYMEEKDDEILQQNN 219
            + + +H  +     L+S R      L Q  QE +E+ E  +  L   ++E    + Q++ 
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817

Query: 220  ELARLQMRFDRAR 232
            EL  LQ    +A+
Sbjct: 1818 ELEALQQEQQQAQ 1830



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 61/297 (20%), Positives = 142/297 (47%), Gaps = 54/297 (18%)

Query: 44   LLEKKKETEIMH---QTMVQKKKMFQRRMETLNL----RWEELGVKEAQL------KAHI 90
            L E+++E E +    Q + ++++M +  +E L+L    R +E+ +++ Q+      ++ +
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489

Query: 91   QKSEQFIQENDQK------RIRAMKKANKERELKCQH-MQELTKRKQEMVALRLEHQRLS 143
            +     +QE +QK      +IR ++K  + +    +H + EL K+ Q + + R + Q L 
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549

Query: 144  AKLKDYYIFNKYLEKVVENSEFEE--IHEVIARYKTL-VSMRH---DLMQSAQEGQEK-- 195
             +L         LE+     E ++  I E+  + +T  V++ H   DL + +QE Q +  
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS 1609

Query: 196  ----IERAKARLARYMEEKDDEILQQNNELARLQMR-------FDRARSNVIFWESRWAH 244
                +E     LAR ++E+D E+  Q  ++  LQ +        +R    ++  + R   
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669

Query: 245  IQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSD 301
            +++   ++T              +I+ + L+++ +++L +  ++L   +Q +Q+R++
Sbjct: 1670 LEDQRTRQT--------------KILEEDLEQI-KLSLRERGRELTTQRQLMQERAE 1711



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 63/320 (19%), Positives = 131/320 (40%), Gaps = 44/320 (13%)

Query: 2    SLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSI--WLLEKKKETEIMHQTMV 59
            +L  +E E +    RL+  +  ++ +Q     E      ++    LE +KE   + +T++
Sbjct: 876  ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935

Query: 60   QKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKC 119
            Q +K      + L    +++ V+    K   Q++   +Q   Q+  R +K+A +      
Sbjct: 936  QTQKELADASQQLERLRQDMKVQ----KLKEQETTGILQTQLQEAQRELKEAAR------ 985

Query: 120  QHMQELTKRKQEMVAL---RLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYK 176
            QH  +L   ++E  +L   +++ Q+    LK   +     +++VE    E++ E      
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET----- 1040

Query: 177  TLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVI 236
                      Q     Q+++ER KA L   + EK+  +L      +  Q      R ++ 
Sbjct: 1041 ----------QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM- 1089

Query: 237  FWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFI 296
              +      +  +A+  LL   +K    +     ++ L+E+   A   T +QL       
Sbjct: 1090 --QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE--ASHITEQQL------- 1138

Query: 297  QDRSDIWAEVKKKEQQRVRI 316
              R+ +WA+  K  Q ++R+
Sbjct: 1139 --RASLWAQEAKAAQLQLRL 1156



 Score = 31.6 bits (70), Expect = 0.96
 Identities = 30/136 (22%), Positives = 59/136 (43%), Gaps = 28/136 (20%)

Query: 118 KCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE-----------NSEFE 166
           K ++ QE  +R+  +V      ++L AK+  Y  + + LEK +E           N E  
Sbjct: 41  KLKNSQEAQQRQATLV------RKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEP 94

Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQM 226
            + E++ R           ++  Q+  E +     +L  +ME+ D        ++ +L +
Sbjct: 95  NLDELLVR-----------LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTV 143

Query: 227 RFDRARSNVIFWESRW 242
            + RAR  ++  ES+W
Sbjct: 144 DWSRARDELMRKESQW 159


>gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromosome
           region, candidate 12 isoform b [Homo sapiens]
          Length = 422

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 54/252 (21%), Positives = 108/252 (42%), Gaps = 14/252 (5%)

Query: 39  SPSIWLLEKKKETEI-MHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFI 97
           SP   L+  +++  + +   M  +KK ++  +     R+    +  + L+  I +    I
Sbjct: 84  SPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKG-RFSRTNII-SDLEEQISELTAII 141

Query: 98  QENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLE 157
           ++ ++    A K  + E +L+C  M++  + K     L+  H+   ++L++ Y      E
Sbjct: 142 EQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNR--ELKEAHEAELSELENNYKAALKAE 199

Query: 158 KVVENSEFEEIHEVIARYKTLVSMRHDLMQSA-QEGQEKIERAKARLARYMEEKDDEILQ 216
           K+    + EE+ +    YK L +M      S   E +EK  + KA+  +  + + + IL 
Sbjct: 200 KLAAQEKLEEMGK---EYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILL 256

Query: 217 QNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKE 276
           Q  +    +   +    +    ES  A  +N   +K  LL   +  TL L     + L++
Sbjct: 257 QQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQL-----EELRK 311

Query: 277 VTEVALEDTHKQ 288
             EV  E+ H Q
Sbjct: 312 TKEVMQEELHAQ 323



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 49/224 (21%), Positives = 96/224 (42%), Gaps = 30/224 (13%)

Query: 28  QKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRR--METLNLRWEELGVKEAQ 85
           Q + N E  S +    + ++KK  E    + +  K  F R   +  L  +  EL     Q
Sbjct: 88  QLVRNREQISVTLGDEMFDRKKRWE----SEIPDKGRFSRTNIISDLEEQISELTAIIEQ 143

Query: 86  LKAHIQKSEQFIQENDQKRIRAMKK--ANKERELKCQHMQELTKRKQEM-VALRLEHQRL 142
           +    Q +++ +      R   MK+   NK RELK  H  EL++ +     AL+ E    
Sbjct: 144 MNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAA 203

Query: 143 SAKLKDYYIFNKYLE---KVVENSEFEEIHEVIARYKT-------------LVSMRHDL- 185
             KL++     KYL+   +  ++S ++E+ E  ++ K              L+  +  + 
Sbjct: 204 QEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMT 263

Query: 186 ----MQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQ 225
               M+S +E ++  E   A    +++EK++ + Q  ++  +L+
Sbjct: 264 KKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE 307


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 52/231 (22%), Positives = 103/231 (44%), Gaps = 32/231 (13%)

Query: 10  DLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRM 69
           D  E  R     +++++  KL +V+G   +  + L +  +  E++ + +  K+++     
Sbjct: 432 DQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVE---- 487

Query: 70  ETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRK 129
                  E+L ++E +L A     ++ +   DQ+     ++  ++ E   + MQ+ T   
Sbjct: 488 -------EQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT--- 537

Query: 130 QEMVALRLEHQRLSAKLKDYYIFNKYLEKVVE-----NSEFEEIHEVI-ARYKTLVSMRH 183
           Q+   L  E Q++SA ++      + LE+  E      S F++  E + A  + L+ +R 
Sbjct: 538 QDHAVLEAERQKMSALVRG---LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594

Query: 184 DLMQSAQEGQEKIE---------RAKARLARYMEEKDDEILQQNNELARLQ 225
           +  +  +E  EKIE         RA A   R +E    E+L+   EL  LQ
Sbjct: 595 EKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQ 645



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 16/187 (8%)

Query: 48  KKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRA 107
           K+E     Q +   ++ +QR  E L    ++     A L+A  QK    ++   ++    
Sbjct: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEET 564

Query: 108 MKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKV-VENSEFE 166
            ++    + +  ++ ++L   KQE++ LR+E + +  +L          EK+ V   E E
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG---------EKIEVLQRELE 615

Query: 167 EIHEVIARYKTLVSMRHDLMQSAQEGQE-KIERAKARLARYMEEKDDEILQQNNELARLQ 225
           +        + +  ++ +L+++ +E +E + ER    +A    +++ E      +LA L+
Sbjct: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE-----KQLAVLR 670

Query: 226 MRFDRAR 232
           +  DR R
Sbjct: 671 VEADRGR 677



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 48/222 (21%), Positives = 94/222 (42%), Gaps = 43/222 (19%)

Query: 18  QYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRME-TLNLRW 76
           ++  R+L + Q+L    G        L++  +  E   +  +Q+ +  ++++E  LN   
Sbjct: 734 EFRRRILGLEQQLKETRG--------LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 785

Query: 77  EE---LGVKEAQLKAHIQKSEQFIQ---ENDQKRIRAMKKANKERELKCQHMQELTKRKQ 130
           EE   L   +  L+A ++++++ +    +  Q   RA+++  K+RE+  +   EL ++K 
Sbjct: 786 EEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQK- 844

Query: 131 EMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQ 190
                     RL  +  D    NK LEK+ E+S+                    L    +
Sbjct: 845 ----------RLLDRTVDR--LNKELEKIGEDSK---------------QALQQLQAQLE 877

Query: 191 EGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRAR 232
           + +EK  R  A   R  ++   E  + +  L+RLQ    R R
Sbjct: 878 DYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.129    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,105,002
Number of Sequences: 37866
Number of extensions: 412158
Number of successful extensions: 4175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 571
Number of HSP's that attempted gapping in prelim test: 2876
Number of HSP's gapped (non-prelim): 1556
length of query: 316
length of database: 18,247,518
effective HSP length: 102
effective length of query: 214
effective length of database: 14,385,186
effective search space: 3078429804
effective search space used: 3078429804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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