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Search of human proteins with 224994251
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224994251 myotubularin related protein 11 isoform a [Homo
sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224994251 myotubularin related protein 11 isoform a [Homo sap... 1467 0.0
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi... 1296 0.0
gi|124028527 myotubularin related protein 10 [Homo sapiens] 308 1e-83
gi|94721263 myotubularin related protein 12 [Homo sapiens] 223 5e-58
gi|19923424 myotubularin related protein 9 [Homo sapiens] 150 5e-36
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens] 144 2e-34
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens] 143 6e-34
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens] 143 6e-34
gi|28872761 myotubularin-related protein 1 [Homo sapiens] 137 3e-32
gi|4557896 myotubularin [Homo sapiens] 127 3e-29
gi|21361759 myotubularin related protein 8 [Homo sapiens] 108 2e-23
gi|217272865 myotubularin related protein 4 [Homo sapiens] 102 1e-21
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens] 102 2e-21
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens] 102 2e-21
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens] 102 2e-21
gi|134142348 myotubularin related protein 6 [Homo sapiens] 99 1e-20
gi|225543474 myotubularin related protein 7 [Homo sapiens] 94 4e-19
gi|239735519 SET binding factor 1 [Homo sapiens] 93 1e-18
gi|29788755 SET binding factor 2 [Homo sapiens] 92 2e-18
gi|239756935 PREDICTED: hypothetical protein XP_002345110 [Homo ... 36 0.14
gi|239751447 PREDICTED: hypothetical protein XP_002347851 [Homo ... 36 0.14
gi|239745952 PREDICTED: hypothetical protein XP_002343584 [Homo ... 35 0.24
gi|7661862 protein phosphatase 1F [Homo sapiens] 35 0.24
gi|195963410 MEF2 activating motif and SAP domain containing tra... 32 1.6
gi|239752306 PREDICTED: hypothetical protein XP_002348194 [Homo ... 32 2.0
gi|239746817 PREDICTED: hypothetical protein XP_002343856 [Homo ... 32 2.0
gi|168823443 RAD54-like 2 [Homo sapiens] 32 2.7
gi|90403590 para-hydroxybenzoate-polyprenyltransferase, mitochon... 32 2.7
gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Ho... 32 2.7
gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Ho... 32 2.7
>gi|224994251 myotubularin related protein 11 isoform a [Homo
sapiens]
Length = 709
Score = 1467 bits (3799), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAWAPGVRK 60
MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAWAPGVRK
Sbjct: 1 MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAWAPGVRK 60
Query: 61 GLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRP 120
GLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRP
Sbjct: 61 GLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRP 120
Query: 121 GSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLS 180
GSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLS
Sbjct: 121 GSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLS 180
Query: 181 KAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRIL 240
KAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRIL
Sbjct: 181 KAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRIL 240
Query: 241 DSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDV 300
DSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDV
Sbjct: 241 DSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDV 300
Query: 301 VLVDTMDELPSLADVQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDI 360
VLVDTMDELPSLADVQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDI
Sbjct: 301 VLVDTMDELPSLADVQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDI 360
Query: 361 SVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLT 420
SVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLT
Sbjct: 361 SVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLT 420
Query: 421 RLGGTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPW 480
RLGGTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPW
Sbjct: 421 RLGGTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPW 480
Query: 481 ERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHC 540
ERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHC
Sbjct: 481 ERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHC 540
Query: 541 PDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSE 600
PDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSE
Sbjct: 541 PDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSE 600
Query: 601 SLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQD 660
SLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQD
Sbjct: 601 SLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQD 660
Query: 661 ELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG 709
ELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG
Sbjct: 661 ELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG 709
>gi|89111941 myotubularin related protein 11 isoform b [Homo
sapiens]
Length = 640
Score = 1296 bits (3353), Expect = 0.0
Identities = 627/629 (99%), Positives = 629/629 (100%)
Query: 76 RVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHG 135
RVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHG
Sbjct: 4 RVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHG 63
Query: 136 RDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPL 195
RDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPL
Sbjct: 64 RDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPL 123
Query: 196 METAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGR 255
METAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGR
Sbjct: 124 METAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGR 183
Query: 256 GPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLADV 315
GPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLADV
Sbjct: 184 GPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLADV 243
Query: 316 QLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE 375
QLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE
Sbjct: 244 QLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE 303
Query: 376 RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFL 435
RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFL
Sbjct: 304 RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFL 363
Query: 436 LFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQV 495
LFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQV
Sbjct: 364 LFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQV 423
Query: 496 YTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLPRPQPSFMVP 555
YTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLPRPQPSFMVP
Sbjct: 424 YTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLPRPQPSFMVP 483
Query: 556 GPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGA 615
GPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGA
Sbjct: 484 GPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGA 543
Query: 616 CPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPR 675
CPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPR
Sbjct: 544 CPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPR 603
Query: 676 ISPEDHSKKRDPHTILNPTEIAGILKGRA 704
ISPEDHSKKRDPHTILNPTEIAGILKG++
Sbjct: 604 ISPEDHSKKRDPHTILNPTEIAGILKGQS 632
>gi|124028527 myotubularin related protein 10 [Homo sapiens]
Length = 777
Score = 308 bits (789), Expect = 1e-83
Identities = 230/679 (33%), Positives = 341/679 (50%), Gaps = 72/679 (10%)
Query: 46 LPGEQILAWAPGVRKGLEPELS-----GTLICTNFRVTF---QPCGWQ-WNQDTPLNSEY 96
LPGE ++ VRK + + S G LIC+NF+++F P Q ++ L E+
Sbjct: 39 LPGEIVVNEVNFVRKCIATDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEH 98
Query: 97 DFALVNIGRLEAVSGLSRVQ-LLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAF 155
D L I ++ V+ R Q +L P KF P E++I+ +DFR++R F+ G E A
Sbjct: 99 DVPLTCIEQIVTVNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPE-SAK 157
Query: 156 QVTMAIVQ----------------ARAQSNQAQQYSGITLSKAGQGSGS-------RKPP 192
+V +AI + N A + +GI G G G
Sbjct: 158 KVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGSSQK 217
Query: 193 IPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFH 252
PL ET DW+ E K+ A GWRV ++NE + ++T LP Y VP+ + D +++ F H
Sbjct: 218 TPLFETYSDWDREIKRTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLK-IFSHSF 276
Query: 253 QGRG-PRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAG--HSDVVLVDTMDEL 309
GR P W H GS L+R K D R + ++ SDV D L
Sbjct: 277 VGRRMPLWCWSHSNGSALVRMALIKDVLQQRKIDQRICNAITKSHPQRSDVYKSDLDKTL 336
Query: 310 PSLADVQLAHLRLRALCLPDS-SVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRV 368
P++ +VQ A ++L+ LC+ + E+KWLS+LE TRWL+YVRA L+ ++++ ++ S+
Sbjct: 337 PNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKH 396
Query: 369 RSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGAS 428
SV+LQE RDL+ ++SLVQ++ P RT+ GFQSL+Q+EWV AG+ FL R S
Sbjct: 397 LSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRS 456
Query: 429 E-EAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSG 487
E E+P+FLLFLD WQLL+Q+PA FEFSE +L L+DS R+ TFL N+P +R KQS
Sbjct: 457 EKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQST 516
Query: 488 QLNSYTQVYTPGYSQPPAGNSFNLQL-SVWDWDLRYSNAQILQFQNPGYDPEHCP----- 541
+ + G+ L+ SVWDW L+++ F NP Y + P
Sbjct: 517 EFAISKNI--------QLGDEKGLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNG 568
Query: 542 -DSWLPRPQPSF--MVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAIS 598
R + S+ + G PS++ + + +L P R+S L + P PA
Sbjct: 569 SVKSFKRTKKSYSSTLRGMPSAL----KNGIISDQELLPRRNSLIL-----KPKPDPAQQ 619
Query: 599 SESLADQEWGLPSHWGACPLP-PGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAP---- 653
++S W + P G++LP G I+LW+ CY R PE Q+ L
Sbjct: 620 TDSQNSDTEQYFREWFSKPANLHGVILPRVSGTHIKLWKLCYFRWVPEAQISLGGSITAF 679
Query: 654 -TISGLQDELSHLQELLRK 671
+S L DE+ L +LR+
Sbjct: 680 HKLSLLADEVDVLSRMLRQ 698
>gi|94721263 myotubularin related protein 12 [Homo sapiens]
Length = 747
Score = 223 bits (568), Expect = 5e-58
Identities = 198/689 (28%), Positives = 309/689 (44%), Gaps = 64/689 (9%)
Query: 46 LPGEQILAWAPGVRKGLEPE-----LSGTLICTNFRVTFQPCGWQW--NQDTPLNS---- 94
LPGEQ+L A V K ++ + + G L+CT+F++ F N +T +
Sbjct: 46 LPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIG 105
Query: 95 EYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQA 154
E D L + ++ V + L G L K+ PE+++IH +D R+ + E +
Sbjct: 106 ENDITLHCVDQIYGVFDEKKKTLF--GQLKKY-PEKLIIHCKDLRVFQFCLRYTK-EEEV 161
Query: 155 FQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPP--IPLMETAEDW--ETERKKQA 210
++ I+ ++ + + A Q + P + +T +DW E ER K
Sbjct: 162 KRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGN 221
Query: 211 ARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLL 270
+ ++ +VNE + V LP YF VP + + V+R GH P W GS LL
Sbjct: 222 MK-YKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGI----PIWCWSCHNGSALL 276
Query: 271 RCGGFYTASDPNKEDIRAVEL------MLQAGHSDVVLVDTMDELPSLADVQLAHLRLRA 324
+ D I+ L + + + V D SL ++Q A+ + +
Sbjct: 277 KMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQ 336
Query: 325 LCLPDSSV----AEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRD 380
L L D+S + KW S LE + WLD +R CL+KA +I+ + ++ +V+L E D
Sbjct: 337 LFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASD 396
Query: 381 LNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--GTGASEEAPVFLLFL 438
L L+SSLVQL+ P RT GFQSL+Q+EWV GH FL R EE PVFLLFL
Sbjct: 397 LCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFL 456
Query: 439 DCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTP 498
DCVWQL+ Q P FEF+E +L L DS+ +P TF N+P ++ G+ TQ
Sbjct: 457 DCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQ---- 512
Query: 499 GYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLP-----RPQPSFM 553
S+P NL L+VWDW +++ +NP Y + D + Q
Sbjct: 513 --SKP-----LNL-LTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLS 564
Query: 554 VPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHW 613
+P ++ +P + + + + + SS+ L D W
Sbjct: 565 LP--------LTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSW 616
Query: 614 GACPLP-PGLLLPGYLGPQIRLWRRCYLRGRPEVQM--GLSAPTISGLQDELSHLQELLR 670
+ GLLLP GP+I++W + YLR PE Q+ G T+S L + + +Q L
Sbjct: 617 HSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQE 676
Query: 671 KWTPRISPEDHSKKRDPHTILNPTEIAGI 699
K R + + P + N ++ +
Sbjct: 677 KIDERHHSQQAPQAEAPCLLRNSARLSSL 705
>gi|19923424 myotubularin related protein 9 [Homo sapiens]
Length = 549
Score = 150 bits (378), Expect = 5e-36
Identities = 108/335 (32%), Positives = 156/335 (46%), Gaps = 46/335 (13%)
Query: 194 PLMETAED-W-------ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVR 245
P+ E ED W E E A WR+S VN+ F V S P VP I D +R
Sbjct: 115 PMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALR 174
Query: 246 RAFGHFHQGRGPRLSWHHP-GGSDLLRCGGFYTASDPN--KEDIRAVELMLQAGHSDVVL 302
+ H GR P LS++H G ++R G T ++ KED + + L+AG +
Sbjct: 175 KVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYI- 233
Query: 303 VDTMD----------------------------ELPSLADVQLAHLRLRALCLPDSSVAE 334
+DT + +Q + ++L C D +
Sbjct: 234 IDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEAC-NDQTHNM 292
Query: 335 DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSA 394
D+WLS LE + WL +++ L A + + S+++ D ++SL Q++
Sbjct: 293 DRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILE 352
Query: 395 PEARTLFGFQSLVQREWVAAGHPFLTRLG-----GTGASEEAPVFLLFLDCVWQLLQQFP 449
P +RT+ GF++L++REW+ AGHPF R T EAPVFLLFLDCVWQ+L+QFP
Sbjct: 353 PRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFP 412
Query: 450 ADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK 484
FEF+E FL+ L + TFL N ER K
Sbjct: 413 CSFEFNENFLIMLFEHAYASQFGTFLGNNESERCK 447
>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
Length = 643
Score = 144 bits (364), Expect = 2e-34
Identities = 148/555 (26%), Positives = 237/555 (42%), Gaps = 98/555 (17%)
Query: 26 ENRMPEPRSRQPSSCLASR----CLPGEQILAWAPGVRK--GLEPELSGTLICTNFRVTF 79
+N P+ R + S+ LA LPGE I A V + GTL TN+R+ F
Sbjct: 55 DNFSPDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF 114
Query: 80 QPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPG--SLHKFIPEEILIHGRD 137
+ +D P + ++N R+E + G S G ++ K I H +
Sbjct: 115 K----SMERDPPFVLDASLGVIN--RVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPE 168
Query: 138 FRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLME 197
R R FE L AF V+ + + + +G L PL+E
Sbjct: 169 GRTRRSIFE--NLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYD------------PLLE 214
Query: 198 TAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGP 257
R+ WR++ +NER+++ + P VP I D E++R +GR P
Sbjct: 215 Y------RRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIP 268
Query: 258 RLSWHHP-GGSDLLRCGG--FYTASDPNKEDIRAVELML--QAGHSDVVLVDTMDELPSL 312
LSW HP + + RC + +KED + ++ ++ A + + D + ++
Sbjct: 269 VLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAV 328
Query: 313 A----------------------DVQLAHL------RLRALCLPDSSVAEDKWLSALEGT 344
A D+ H+ +L+ + P ++ E WLS LE T
Sbjct: 329 ANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYP--NIEETHWLSNLEST 386
Query: 345 RWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQ 404
WL++++ L A I+ V S SV++ D L+SL L+ RT+ GF+
Sbjct: 387 HWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFE 446
Query: 405 SLVQREWVAAGHPFLTRLG----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLL 460
LV++EW++ GH F R+G ++ +PVFL F+DCVWQ+ +QFP FEF+E+FL+
Sbjct: 447 VLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLI 506
Query: 461 ALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDL 520
+ D + TFL N+ +RGK+ N +S+W
Sbjct: 507 TILDHLYSCLFGTFLCNSEQQRGKE---------------------NLPKRTVSLWS--- 542
Query: 521 RYSNAQILQFQNPGY 535
Y N+Q+ F NP Y
Sbjct: 543 -YINSQLEDFTNPLY 556
>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 143 bits (360), Expect = 6e-34
Identities = 142/531 (26%), Positives = 227/531 (42%), Gaps = 94/531 (17%)
Query: 46 LPGEQILAWAPGVRK--GLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNI 103
LPGE I A V + GTL TN+R+ F+ +D P + ++N
Sbjct: 7 LPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFK----SMERDPPFVLDASLGVIN- 61
Query: 104 GRLEAVSGLSRVQLLRPG--SLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAI 161
R+E + G S G ++ K I H + R R FE L AF V+ +
Sbjct: 62 -RVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFE--NLMKYAFPVSNNL 118
Query: 162 VQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNE 221
+ + +G L PL+E R+ WR++ +NE
Sbjct: 119 PLFAFEYKEVFPENGWKLYD------------PLLEY------RRQGIPNESWRITKINE 160
Query: 222 RFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRCGG--FYTA 278
R+++ + P VP I D E++R +GR P LSW HP + + RC +
Sbjct: 161 RYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVS 220
Query: 279 SDPNKEDIRAVELML--QAGHSDVVLVDTMDELPSLA----------------------D 314
+KED + ++ ++ A + + D + ++A D
Sbjct: 221 GKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLD 280
Query: 315 VQLAHL------RLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRV 368
+ H+ +L+ + P ++ E WLS LE T WL++++ L A I+ V S
Sbjct: 281 IHNIHVMRESLRKLKEIVYP--NIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGK 338
Query: 369 RSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG----G 424
SV++ D L+SL L+ RT+ GF+ LV++EW++ GH F R+G
Sbjct: 339 TSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKN 398
Query: 425 TGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK 484
++ +PVFL F+DCVWQ+ +QFP FEF+E+FL+ + D + TFL N+ +RGK
Sbjct: 399 HADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGK 458
Query: 485 QSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGY 535
+ N +S+W Y N+Q+ F NP Y
Sbjct: 459 E---------------------NLPKRTVSLWS----YINSQLEDFTNPLY 484
>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 143 bits (360), Expect = 6e-34
Identities = 142/531 (26%), Positives = 227/531 (42%), Gaps = 94/531 (17%)
Query: 46 LPGEQILAWAPGVRK--GLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNI 103
LPGE I A V + GTL TN+R+ F+ +D P + ++N
Sbjct: 7 LPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFK----SMERDPPFVLDASLGVIN- 61
Query: 104 GRLEAVSGLSRVQLLRPG--SLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAI 161
R+E + G S G ++ K I H + R R FE L AF V+ +
Sbjct: 62 -RVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFE--NLMKYAFPVSNNL 118
Query: 162 VQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNE 221
+ + +G L PL+E R+ WR++ +NE
Sbjct: 119 PLFAFEYKEVFPENGWKLYD------------PLLEY------RRQGIPNESWRITKINE 160
Query: 222 RFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRCGG--FYTA 278
R+++ + P VP I D E++R +GR P LSW HP + + RC +
Sbjct: 161 RYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVS 220
Query: 279 SDPNKEDIRAVELML--QAGHSDVVLVDTMDELPSLA----------------------D 314
+KED + ++ ++ A + + D + ++A D
Sbjct: 221 GKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLD 280
Query: 315 VQLAHL------RLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRV 368
+ H+ +L+ + P ++ E WLS LE T WL++++ L A I+ V S
Sbjct: 281 IHNIHVMRESLRKLKEIVYP--NIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGK 338
Query: 369 RSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG----G 424
SV++ D L+SL L+ RT+ GF+ LV++EW++ GH F R+G
Sbjct: 339 TSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKN 398
Query: 425 TGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK 484
++ +PVFL F+DCVWQ+ +QFP FEF+E+FL+ + D + TFL N+ +RGK
Sbjct: 399 HADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGK 458
Query: 485 QSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGY 535
+ N +S+W Y N+Q+ F NP Y
Sbjct: 459 E---------------------NLPKRTVSLWS----YINSQLEDFTNPLY 484
>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
Length = 665
Score = 137 bits (345), Expect = 3e-32
Identities = 104/370 (28%), Positives = 169/370 (45%), Gaps = 68/370 (18%)
Query: 203 ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWH 262
E +R+ W++S +N ++ + P VP + D ++ + +GR P LSW
Sbjct: 235 EYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWI 294
Query: 263 HP-GGSDLLRCGGFYTASDPN----KEDIRAVELMLQAGHSDVVLVDTMDELPSLAD--- 314
HP + + RC PN KED + ++ ++ A L+ S+AD
Sbjct: 295 HPESQATITRCS--QPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNK 352
Query: 315 --------------VQLAHL-------------RLRALCLPDSSVAEDKWLSALEGTRWL 347
+L L +L+ + P S+ E +WLS ++GT WL
Sbjct: 353 TKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYP--SIDEARWLSNVDGTHWL 410
Query: 348 DYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLV 407
+Y+R L A I+ + S SV++ D L+SL L+ RT+ GF++LV
Sbjct: 411 EYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLV 470
Query: 408 QREWVAAGHPFLTRLG----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALH 463
++EW++ GH F R+G ++ +P+FL F+DCVWQ+ +QFP+ FEF+E FL+ +
Sbjct: 471 EKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITIL 530
Query: 464 DSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYS 523
D + TFL N +R K+ VYT +S+W Y
Sbjct: 531 DHLYSCLFGTFLCNCEQQRFKE--------DVYTK-------------TISLWS----YI 565
Query: 524 NAQILQFQNP 533
N+Q+ +F NP
Sbjct: 566 NSQLDEFSNP 575
>gi|4557896 myotubularin [Homo sapiens]
Length = 603
Score = 127 bits (320), Expect = 3e-29
Identities = 87/307 (28%), Positives = 150/307 (48%), Gaps = 35/307 (11%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLL-RC 272
WR++ +N+ +++ + P VP R D ++RR + R P LSW HP ++ RC
Sbjct: 183 WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRC 242
Query: 273 GGFYT--ASDPNKEDIRAVELMLQAGH--SDVVLVDTMDELPSLA--------------- 313
+ NK+D + ++++ + S + + D + ++A
Sbjct: 243 SQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYH 302
Query: 314 -------DVQLAHLRLRALC----LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISV 362
D+ H+ +L + +V E WLS+LE T WL++++ L A ++
Sbjct: 303 NAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVAD 362
Query: 363 LVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRL 422
V+S SV++ D L+SL L+ R++ GF+ LVQ+EW++ GH F +R+
Sbjct: 363 KVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRI 422
Query: 423 G----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNT 478
G ++ +P+FL F+DCVWQ+ +QFP FEF+E FL+ + D + TFL N
Sbjct: 423 GHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNC 482
Query: 479 PWERGKQ 485
R +Q
Sbjct: 483 ESARERQ 489
>gi|21361759 myotubularin related protein 8 [Homo sapiens]
Length = 704
Score = 108 bits (269), Expect = 2e-23
Identities = 81/305 (26%), Positives = 137/305 (44%), Gaps = 35/305 (11%)
Query: 212 RGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLL 270
R W ++ N +++ ++ P VP + V + + R P LS+ + + +
Sbjct: 144 RNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAIC 203
Query: 271 RCG----GFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLA----------DVQ 316
RC GFYT ++ + A+ G + +VDT +L ++A +
Sbjct: 204 RCSQPLSGFYTRCVDDELLLEAIS-QTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDN 262
Query: 317 LAHLRLRALCLPDSSVAED-----------------KWLSALEGTRWLDYVRACLRKASD 359
A++R R + + + V ++LS LE + WL +++A +
Sbjct: 263 YANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIF 322
Query: 360 ISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFL 419
I+ V SV++ D + S+ +L P RT G L+++EW++ GH F
Sbjct: 323 ITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFS 382
Query: 420 TRLGGTG--ASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRN 477
R G + E +P+F FLDC+WQL++QFP FEF+E FLL +HD V FL N
Sbjct: 383 QRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGN 442
Query: 478 TPWER 482
+R
Sbjct: 443 CQKDR 447
>gi|217272865 myotubularin related protein 4 [Homo sapiens]
Length = 1195
Score = 102 bits (254), Expect = 1e-21
Identities = 73/197 (37%), Positives = 100/197 (50%), Gaps = 24/197 (12%)
Query: 322 LRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDR 379
LRA+C +PD S WLSALE T+WL ++ L+ A ++ V R V++
Sbjct: 356 LRAVCSQMPDPS----NWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGW 411
Query: 380 DLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGG----TGASEEAPVFL 435
D + +L ++L P RTL GFQ LV+ +W+ GH F R G +E+ PVFL
Sbjct: 412 DRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFL 471
Query: 436 LFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK----------- 484
+LD V QLL+QFP FEF+E FL+ L TFL N P ER K
Sbjct: 472 QWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVW 531
Query: 485 ---QSGQLNSYTQVYTP 498
++G N + +YTP
Sbjct: 532 ALLRAGNKNFHNFLYTP 548
Score = 31.2 bits (69), Expect = 3.5
Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 1/60 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHH-PGGSDLLRC 272
WRVS +N + + S P+ VP I D E+ R P + + H G+ + RC
Sbjct: 174 WRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARC 233
>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
Length = 1161
Score = 102 bits (253), Expect = 2e-21
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 309 LPSLADVQLAHLRLRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTS 366
+ ++ ++ + LR LC +PD WLSALE T+WL ++ L+ A + V
Sbjct: 349 MANIHSIRRSFQSLRLLCTQMPDPG----NWLSALESTKWLHHLSVLLKSALLVVHAVDQ 404
Query: 367 RVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--- 423
R V++ D + +L +LL P RT+ GFQ LV+ EW+ GH F R G
Sbjct: 405 DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGE 464
Query: 424 -GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
+E PVFL +LDCV QL +QFP FEF+E FL+ L TFL N ER
Sbjct: 465 NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER 524
Query: 483 GKQSGQLNSYTQVYTPGYSQPPAGNSF--NLQLSVWDWDLRYSNAQI--LQFQNPGYDPE 538
G++ Q + + +S AGN NL S + Y + L + Y P
Sbjct: 525 GEKHTQERTCSV-----WSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP- 578
Query: 539 HCP-------DSWLPRPQPSFMVPGPPSS 560
CP DS P P P PP S
Sbjct: 579 -CPSPTTPVDDSCAPYPAPGTSPDDPPLS 606
Score = 36.6 bits (83), Expect = 0.082
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLLRC 272
WR+S +NE++ + S P+ VP I D E+ R P + + H G+ + RC
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 273 G 273
G
Sbjct: 236 G 236
>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
Length = 1170
Score = 102 bits (253), Expect = 2e-21
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 309 LPSLADVQLAHLRLRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTS 366
+ ++ ++ + LR LC +PD WLSALE T+WL ++ L+ A + V
Sbjct: 349 MANIHSIRRSFQSLRLLCTQMPDPG----NWLSALESTKWLHHLSVLLKSALLVVHAVDQ 404
Query: 367 RVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--- 423
R V++ D + +L +LL P RT+ GFQ LV+ EW+ GH F R G
Sbjct: 405 DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGE 464
Query: 424 -GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
+E PVFL +LDCV QL +QFP FEF+E FL+ L TFL N ER
Sbjct: 465 NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER 524
Query: 483 GKQSGQLNSYTQVYTPGYSQPPAGNSF--NLQLSVWDWDLRYSNAQI--LQFQNPGYDPE 538
G++ Q + + +S AGN NL S + Y + L + Y P
Sbjct: 525 GEKHTQERTCSV-----WSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP- 578
Query: 539 HCP-------DSWLPRPQPSFMVPGPPSS 560
CP DS P P P PP S
Sbjct: 579 -CPSPTTPVDDSCAPYPAPGTSPDDPPLS 606
Score = 36.6 bits (83), Expect = 0.082
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLLRC 272
WR+S +NE++ + S P+ VP I D E+ R P + + H G+ + RC
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 273 G 273
G
Sbjct: 236 G 236
>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
Length = 1198
Score = 102 bits (253), Expect = 2e-21
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 309 LPSLADVQLAHLRLRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTS 366
+ ++ ++ + LR LC +PD WLSALE T+WL ++ L+ A + V
Sbjct: 349 MANIHSIRRSFQSLRLLCTQMPDPG----NWLSALESTKWLHHLSVLLKSALLVVHAVDQ 404
Query: 367 RVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--- 423
R V++ D + +L +LL P RT+ GFQ LV+ EW+ GH F R G
Sbjct: 405 DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGE 464
Query: 424 -GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
+E PVFL +LDCV QL +QFP FEF+E FL+ L TFL N ER
Sbjct: 465 NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER 524
Query: 483 GKQSGQLNSYTQVYTPGYSQPPAGNSF--NLQLSVWDWDLRYSNAQI--LQFQNPGYDPE 538
G++ Q + + +S AGN NL S + Y + L + Y P
Sbjct: 525 GEKHTQERTCSV-----WSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP- 578
Query: 539 HCP-------DSWLPRPQPSFMVPGPPSS 560
CP DS P P P PP S
Sbjct: 579 -CPSPTTPVDDSCAPYPAPGTSPDDPPLS 606
Score = 36.6 bits (83), Expect = 0.082
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLLRC 272
WR+S +NE++ + S P+ VP I D E+ R P + + H G+ + RC
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 273 G 273
G
Sbjct: 236 G 236
>gi|134142348 myotubularin related protein 6 [Homo sapiens]
Length = 621
Score = 99.4 bits (246), Expect = 1e-20
Identities = 87/334 (26%), Positives = 148/334 (44%), Gaps = 39/334 (11%)
Query: 184 QGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSE 243
Q R L++ AE+++ R W++S N + + + PR +VP RI
Sbjct: 116 QNDSERLQGWQLIDLAEEYK--RMGVPNSHWQLSDANRDYKICETYPRELYVP-RIASKP 172
Query: 244 VRRAFGHFH-QGRGPRLSWHHPGG-SDLLRCG----GFYTASDPNKEDIRAVELMLQAGH 297
+ F +GR P LS++H + + RC GF ++ ++A+
Sbjct: 173 IIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNR 232
Query: 298 SDVVLVDTMDELPSLAD---------------VQLAHLRLRALCLPDSSVAE-------- 334
V+ DT +L ++A+ ++ + + + + SS+ +
Sbjct: 233 YMYVM-DTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTK 291
Query: 335 ----DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQ 390
+ + S LE + WL +++A + A ++ +T SV++ D + SL
Sbjct: 292 GLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGS 351
Query: 391 LLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGAS--EEAPVFLLFLDCVWQLLQQF 448
LL RT+ GF L++++W++ GH F R G E +PVF FL+CVW L +QF
Sbjct: 352 LLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQF 411
Query: 449 PADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
P FEFSE FLL +H+ + FL N ER
Sbjct: 412 PQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKER 445
>gi|225543474 myotubularin related protein 7 [Homo sapiens]
Length = 660
Score = 94.0 bits (232), Expect = 4e-19
Identities = 81/316 (25%), Positives = 141/316 (44%), Gaps = 39/316 (12%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGG-SDLLRC 272
W++S VN + V S P +VP + + + R P LS+++ + + R
Sbjct: 146 WQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRS 205
Query: 273 G----GFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLAD-------------- 314
GF +++ ++A+ G V +VDT +L ++A+
Sbjct: 206 SQPLSGFSARCLEDEQMLQAIR-KANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYS 264
Query: 315 --------VQLAHLRLRAL------C-LPDSSVAEDKWLSALEGTRWLDYVRACLRKASD 359
++ H+ +L C L S+++ W LE + WL +++A +
Sbjct: 265 NIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLW--GLENSGWLRHIKAIMDAGIF 322
Query: 360 ISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFL 419
I+ V+ SV++ D + S+ LL P RTL GF L++++W++ GH F
Sbjct: 323 IAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFN 382
Query: 420 TRLGGTGA--SEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRN 477
R G E +PV F++CVWQL++QFP FEF+E FL+ + + FL N
Sbjct: 383 HRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCN 442
Query: 478 TPWERGKQSGQLNSYT 493
+ ER + Q +Y+
Sbjct: 443 SQKERRELKIQERTYS 458
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/180 (38%), Positives = 99/180 (55%), Gaps = 19/180 (10%)
Query: 315 VQLAHLRLRALCLPDSSVAEDK---WLSALEGTRWLDYVRACLRKASDISVLVTSRV--- 368
V+ + +L C+P AE +L +LE + WL + L+ +SVLV +
Sbjct: 1385 VKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQ----VSVLVVELLDSG 1440
Query: 369 RSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGAS 428
SV++ D+ + SLVQLLS P RTL GF+ LV++EW++ GH F R T A
Sbjct: 1441 SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG 1500
Query: 429 EEA---PVFLLFLDCVWQLLQQFPADFEFSEFFLLAL---HDSVRVPDTLTFLRNTPWER 482
+ + PVFL FLDCV Q+ QFP +FEFS+F+L L H S R TFL ++ +ER
Sbjct: 1501 QSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRF---RTFLLDSDYER 1557
Score = 34.3 bits (77), Expect = 0.41
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHH-PGGSDLLRC 272
+R+S VN + + S P VP + D+ ++R + Q R P + W + LLR
Sbjct: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209
Query: 273 GGFY 276
GG +
Sbjct: 1210 GGLH 1213
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 92.0 bits (227), Expect = 2e-18
Identities = 62/180 (34%), Positives = 97/180 (53%), Gaps = 6/180 (3%)
Query: 308 ELPSLADVQLAHLRLRALCLPDS--SVAEDKWLSALEGTRWLDYVRACLRKASDISVLVT 365
E + V+ + +L C+P + + +E +L AL + W + ++ A +S ++
Sbjct: 1342 EFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE 1401
Query: 366 SRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGT 425
+ ++ E G D+ ++SLVQLLS P RTL GFQ LV++EW++ GH F R T
Sbjct: 1402 NGSSVLVCLEEG-WDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLT 1460
Query: 426 ---GASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
S APVFL FLDCV Q+ Q+P +FEF+ ++L L TFL ++ +ER
Sbjct: 1461 LNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYER 1520
Score = 35.0 bits (79), Expect = 0.24
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRC 272
+R++ N + + S P VP + DS + R + R P + W + G+ LLR
Sbjct: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
Query: 273 GGFY 276
GGF+
Sbjct: 1198 GGFH 1201
>gi|239756935 PREDICTED: hypothetical protein XP_002345110 [Homo
sapiens]
Length = 237
Score = 35.8 bits (81), Expect = 0.14
Identities = 46/168 (27%), Positives = 62/168 (36%), Gaps = 27/168 (16%)
Query: 482 RGKQSGQLNSYTQVYTPGY----------SQPPAGNSFNLQLSVWDWDLRYSNAQILQFQ 531
RG+Q+G L Q Y PG P A N F L LS Q
Sbjct: 73 RGRQNGGLPRSEQPYRPGRWREGWRSCSGDLPSAWNWFLLCLSACGCPSALVTPQAPAVP 132
Query: 532 NPGY--DPEHC-PDSW-LPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAV 587
+PGY P C P W P+P + G + L + + CP DS
Sbjct: 133 SPGYVPAPSFCHPHQWAASEPRPFWGYRGGCTRSMLCTEEQAVGADATCP-ADS------ 185
Query: 588 SSRWLPRPAISSESLADQEWG------LPSHWGACPLPPGLLLPGYLG 629
SS PA+ +++ +WG P+H A PLP +L + G
Sbjct: 186 SSPSKADPALGERGVSEVDWGEAAPSPTPAHSMAHPLPARVLGSAFHG 233
>gi|239751447 PREDICTED: hypothetical protein XP_002347851 [Homo
sapiens]
Length = 237
Score = 35.8 bits (81), Expect = 0.14
Identities = 46/168 (27%), Positives = 62/168 (36%), Gaps = 27/168 (16%)
Query: 482 RGKQSGQLNSYTQVYTPGY----------SQPPAGNSFNLQLSVWDWDLRYSNAQILQFQ 531
RG+Q+G L Q Y PG P A N F L LS Q
Sbjct: 73 RGRQNGGLPRSEQPYRPGRWREGWRSCSGDLPSAWNWFLLCLSACGCPSALVTPQAPAVP 132
Query: 532 NPGY--DPEHC-PDSW-LPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAV 587
+PGY P C P W P+P + G + L + + CP DS
Sbjct: 133 SPGYVPAPSFCHPHQWAASEPRPFWGYRGGCTRSMLCTEEQAVGADATCP-ADS------ 185
Query: 588 SSRWLPRPAISSESLADQEWG------LPSHWGACPLPPGLLLPGYLG 629
SS PA+ +++ +WG P+H A PLP +L + G
Sbjct: 186 SSPSKADPALGERGVSEVDWGEAAPSPTPAHSMAHPLPARVLGSAFHG 233
>gi|239745952 PREDICTED: hypothetical protein XP_002343584 [Homo
sapiens]
Length = 237
Score = 35.0 bits (79), Expect = 0.24
Identities = 46/168 (27%), Positives = 61/168 (36%), Gaps = 27/168 (16%)
Query: 482 RGKQSGQLNSYTQVYTPGY----------SQPPAGNSFNLQLSVWDWDLRYSNAQILQFQ 531
RG+Q+G L Q Y PG P A N F L LS Q
Sbjct: 73 RGRQNGGLPRSEQPYRPGRWREGWRSCSGDLPSAWNWFLLCLSACGCPSALVTPQAPAVP 132
Query: 532 NPGY--DPEHC-PDSW-LPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAV 587
+PGY P C P W P+P + G + L + + CP DS
Sbjct: 133 SPGYVPAPSFCHPHQWAASEPRPFWGYRGGCTRSMLCTEEQAVGADATCP-ADS------ 185
Query: 588 SSRWLPRPAISSESLADQEWG------LPSHWGACPLPPGLLLPGYLG 629
SS PA+ +++ +WG P+H A PLP L + G
Sbjct: 186 SSPSKADPALGERGVSEVDWGEAAPSPTPAHSMAHPLPARALGSAFHG 233
>gi|7661862 protein phosphatase 1F [Homo sapiens]
Length = 454
Score = 35.0 bits (79), Expect = 0.24
Identities = 20/59 (33%), Positives = 31/59 (52%)
Query: 651 SAPTISGLQDELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG 709
S+P SG ++ L LL+ + ++PED + P T+L+ E+ G L A G LG
Sbjct: 9 SSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLG 67
>gi|195963410 MEF2 activating motif and SAP domain containing
transcriptional regulator isoform 1 [Homo sapiens]
Length = 415
Score = 32.3 bits (72), Expect = 1.6
Identities = 22/58 (37%), Positives = 28/58 (48%), Gaps = 11/58 (18%)
Query: 541 PDSWLPRPQPSFMVPGPPSSV--WLFSRGALTPLNQLC-PWR----DSPSLLAVSSRW 591
PD W+ P + P PS +LFS G L P + C PWR +SP +S RW
Sbjct: 36 PDPWISASDPP-LAPALPSGTAPFLFSPGVLLPEPEYCPPWRSPKKESPK---ISQRW 89
>gi|239752306 PREDICTED: hypothetical protein XP_002348194 [Homo
sapiens]
Length = 160
Score = 32.0 bits (71), Expect = 2.0
Identities = 23/77 (29%), Positives = 28/77 (36%), Gaps = 7/77 (9%)
Query: 541 PDSWLPRPQPSFMV---PGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAI 597
P +W P P P V PGPPS + L C W S + + W P
Sbjct: 30 PGAWRPEPLPDPGVRSGPGPPSRLGLSGSSRSRGFRPFCGWEIS----GLEAAWPPACPA 85
Query: 598 SSESLADQEWGLPSHWG 614
S + A G PS G
Sbjct: 86 VSITTAGSRAGTPSCGG 102
>gi|239746817 PREDICTED: hypothetical protein XP_002343856 [Homo
sapiens]
Length = 160
Score = 32.0 bits (71), Expect = 2.0
Identities = 23/77 (29%), Positives = 28/77 (36%), Gaps = 7/77 (9%)
Query: 541 PDSWLPRPQPSFMV---PGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAI 597
P +W P P P V PGPPS + L C W S + + W P
Sbjct: 30 PGAWRPEPLPDPGVRSGPGPPSRLGLSGSSRSRGFRPFCGWEIS----GLEAAWPPACPA 85
Query: 598 SSESLADQEWGLPSHWG 614
S + A G PS G
Sbjct: 86 VSITTAGSRAGTPSCGG 102
>gi|168823443 RAD54-like 2 [Homo sapiens]
Length = 1467
Score = 31.6 bits (70), Expect = 2.7
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 4/55 (7%)
Query: 33 RSRQPSSCLASRCLPGE--QIL--AWAPGVRKGLEPELSGTLICTNFRVTFQPCG 83
R + SS + LPG Q++ + PG G EP L G + ++ VT QPCG
Sbjct: 1189 RESRQSSPSTNAALPGPPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCG 1243
>gi|90403590 para-hydroxybenzoate-polyprenyltransferase,
mitochondrial [Homo sapiens]
Length = 384
Score = 31.6 bits (70), Expect = 2.7
Identities = 17/40 (42%), Positives = 21/40 (52%)
Query: 4 GGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLAS 43
G RG+SF +A P G +Q PEPR RQ S A+
Sbjct: 36 GWRGRSFALARAAGAPHGGDLQPPACPEPRGRQLSLSAAA 75
>gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Homo
sapiens]
Length = 152
Score = 31.6 bits (70), Expect = 2.7
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 555 PGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRP 595
PGP +++ + GA PWR LL + RWLPRP
Sbjct: 98 PGPKAALAVIRGGATRAAGVFYPWRFR--LLCLLRRWLPRP 136
>gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Homo
sapiens]
Length = 205
Score = 31.6 bits (70), Expect = 2.7
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 555 PGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRP 595
PGP +++ + GA PWR LL + RWLPRP
Sbjct: 151 PGPKAALAVIRGGATRAAGVFYPWRFR--LLCLLRRWLPRP 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,916,648
Number of Sequences: 37866
Number of extensions: 1655638
Number of successful extensions: 4460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 4375
Number of HSP's gapped (non-prelim): 79
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.