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Search of human proteins with 223005862
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223005862 echinoderm microtubule associated protein like 6
[Homo sapiens]
(1958 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223005862 echinoderm microtubule associated protein like 6 [H... 4018 0.0
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 3159 0.0
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 405 e-112
gi|56790932 echinoderm microtubule associated protein like 1 iso... 394 e-109
gi|56790930 echinoderm microtubule associated protein like 1 iso... 394 e-109
gi|223029510 echinoderm microtubule associated protein like 4 is... 384 e-106
gi|19923497 echinoderm microtubule associated protein like 4 iso... 384 e-106
gi|110227615 echinoderm microtubule associated protein like 3 [H... 323 8e-88
gi|94400919 WD repeat domain 90 [Homo sapiens] 179 3e-44
gi|31377846 WD repeat domain 52 [Homo sapiens] 134 7e-31
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 100 1e-20
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 100 1e-20
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 97 2e-19
gi|145279222 WD repeat domain 66 [Homo sapiens] 77 1e-13
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 75 8e-13
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 72 5e-12
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 72 5e-12
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 68 1e-10
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 67 1e-10
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 67 2e-10
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 65 8e-10
gi|23199987 WD repeat domain 5B [Homo sapiens] 65 8e-10
gi|16554629 WD repeat domain 5 [Homo sapiens] 64 2e-09
gi|16554627 WD repeat domain 5 [Homo sapiens] 64 2e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 62 4e-09
gi|32189425 WD repeat domain 69 [Homo sapiens] 62 6e-09
gi|21071067 TBP-associated factor 5 [Homo sapiens] 62 7e-09
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 60 2e-08
gi|13376840 WD repeat domain 61 [Homo sapiens] 60 2e-08
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 59 5e-08
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 4018 bits (10420), Expect = 0.0
Identities = 1958/1958 (100%), Positives = 1958/1958 (100%)
Query: 1 MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH 60
MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH
Sbjct: 1 MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH 60
Query: 61 NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR 120
NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR
Sbjct: 61 NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR 120
Query: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC 180
LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC
Sbjct: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC 180
Query: 181 GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI 240
GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI
Sbjct: 181 GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI 240
Query: 241 FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT 300
FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT
Sbjct: 241 FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT 300
Query: 301 QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI 360
QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI
Sbjct: 301 QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI 360
Query: 361 ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG 420
ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG
Sbjct: 361 ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG 420
Query: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM 480
SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM
Sbjct: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM 480
Query: 481 PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG 540
PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG
Sbjct: 481 PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG 540
Query: 541 LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN 600
LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN
Sbjct: 541 LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN 600
Query: 601 GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK 660
GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK
Sbjct: 601 GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK 660
Query: 661 NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ 720
NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ
Sbjct: 661 NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ 720
Query: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF
Sbjct: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
Query: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI 840
SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI
Sbjct: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI 840
Query: 841 KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK 900
KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK
Sbjct: 841 KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK 900
Query: 901 AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS 960
AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS
Sbjct: 901 AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS 960
Query: 961 IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK 1020
IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK
Sbjct: 961 IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK 1020
Query: 1021 TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH 1080
TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH
Sbjct: 1021 TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH 1080
Query: 1081 RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL
Sbjct: 1081 RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
Query: 1141 QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS 1200
QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS
Sbjct: 1141 QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS 1200
Query: 1201 LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD 1260
LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD
Sbjct: 1201 LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD 1260
Query: 1261 TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG 1320
TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG
Sbjct: 1261 TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG 1320
Query: 1321 TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL 1380
TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL
Sbjct: 1321 TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL 1380
Query: 1381 HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT 1440
HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT
Sbjct: 1381 HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT 1440
Query: 1441 PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA 1500
PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA
Sbjct: 1441 PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA 1500
Query: 1501 SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS 1560
SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS
Sbjct: 1501 SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS 1560
Query: 1561 VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK 1620
VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK
Sbjct: 1561 VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK 1620
Query: 1621 EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI 1680
EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI
Sbjct: 1621 EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI 1680
Query: 1681 LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG 1740
LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG
Sbjct: 1681 LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG 1740
Query: 1741 EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT
Sbjct: 1741 EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
Query: 1801 QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT 1860
QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT
Sbjct: 1801 QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT 1860
Query: 1861 WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH 1920
WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH
Sbjct: 1861 WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH 1920
Query: 1921 KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL
Sbjct: 1921 KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 3159 bits (8191), Expect = 0.0
Identities = 1466/1973 (74%), Positives = 1713/1973 (86%), Gaps = 15/1973 (0%)
Query: 1 MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH 60
MA R+AP C LRLEWVYGYRGHQCRNNLYYTA KE+VYFVAGVGVVY+ REH QKF+ GH
Sbjct: 1 MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH 60
Query: 61 NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR 120
+DDIISLALHP++ LVATGQVGKEPYICIWDSY VQT+S+LKDVHTHG+ACLAFD DGQR
Sbjct: 61 SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR 120
Query: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC 180
L SVGLD+KN VC+WDW++GK+L+ A GH+DRIFDISWD YQPN++VSCGVKHIKFW+LC
Sbjct: 121 LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC 180
Query: 181 GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI 240
GNALT KRG+FGKTGDLQTILCLACA++++TYSGALNGDIYVWKG+NL+RTIQGAH+AGI
Sbjct: 181 GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI 240
Query: 241 FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT 300
FSM ACEEGFATGGRDGCIRLWD FKPIT IDLRET+QGYKGLS+RSVCW+ D +L GT
Sbjct: 241 FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT 300
Query: 301 QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI 360
QDSEIFE++V+ER+KP LI+QGHCEGELWALA+HP KPLAVTGSDDRSVR+WSL DHALI
Sbjct: 301 QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI 360
Query: 361 ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG 420
ARCNMEE +R A + DG LALGMKDGSF VLRVRDMTEVVHIKDRKE IHE+K+SPDG
Sbjct: 361 ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG 420
Query: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM 480
+YLAVG ND VD+Y VAQRYKK+GEC SLSFITH+DWS DS+YLQTNDG G+RLFYRM
Sbjct: 421 TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM 480
Query: 481 PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG 540
P GK +TS EEIKG+ WASWTCV G EV+GIWPKY+++ DINSVD NY VLV+ DD+G
Sbjct: 481 PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG 540
Query: 541 LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN 600
++KLF++PCL++GAKFRKY+GHSAHVTNVRWSHD+QWV+S GGADHSVFQW+FIPE
Sbjct: 541 IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK 600
Query: 601 GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK 660
+ APQE ADS+S+ESDSDLSDVPELDS+IEQE Q+ Y RQVYKEDLPQLK+Q KEK
Sbjct: 601 DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK 660
Query: 661 NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ 720
+ +RE+AP +S++L F+HGYRGYDCR+NLFYTQ GE+VYH+AAV V+YNRQQ++Q
Sbjct: 661 QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ 720
Query: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
R YLGHDDDIL LTIHP+KDYVATGQVGRD +IH+WDT+T+K LS+LKG HQ GV A+DF
Sbjct: 721 RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF 780
Query: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI 840
SADGK L SVG+DD H++V WDWKKGEK++ RG KDKIFVVK NP+ DKL+T GIKH+
Sbjct: 781 SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM 840
Query: 841 KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK 900
KFW++AGGG ++G G++GK +TMMC YG E++ FSG +TGD+ IW+DI L+KTVK
Sbjct: 841 KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK 900
Query: 901 AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS 960
AHDGPVF+M+AL+KGFVTGGKDGIV LWDD FERCLKTYAIKR+AL+ SKGLLLEDNPS
Sbjct: 901 AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS 960
Query: 961 IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK 1020
IRAI+LGHGHILVGTKNGEILE+DKSGP+TLLVQGHMEGEVWGLA HP LPICATVSDDK
Sbjct: 961 IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK 1020
Query: 1021 TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH 1080
TLRIW+LS H MLAVRKLKKGGRCC FSPDGKALAVGLNDGSFL+ NADT+ED+VSFHH
Sbjct: 1021 TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH 1080
Query: 1081 RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
RK+MISDI+FS +GKYLAVASHD+F+DIYNV++SKRVGICKGA+SYITHIDWD RGKLL
Sbjct: 1081 RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL 1140
Query: 1141 QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS 1200
QVN+GA+EQLFFEAPRGK+ I E+EKI W +WT VLG CEGIWP ++TDV A+
Sbjct: 1141 QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC 1200
Query: 1201 LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD 1260
LT D +LATGDD GFVKLF YP KG+ +FK+YV HS HVTNVRW ++DS+L+T+GG D
Sbjct: 1201 LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD 1260
Query: 1261 TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG 1320
+LM+WT E G +E + DSEESD D EEDGGYDSDV RE I YT + + +IR M G
Sbjct: 1261 MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG 1320
Query: 1321 TKPHQQLKEVSVEE--------RPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYR 1372
KPH Q KE S++E RPPVSRA PQPEKLQ NN+ KKK+ +E+L L+ +FGYR
Sbjct: 1321 IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYR 1380
Query: 1373 GFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVV 1432
G DCRNN+HYLNDG DII+HTA+ GI+ N++TGSQSFY EH DDILCLTVNQHPK+ N+V
Sbjct: 1381 GRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIV 1440
Query: 1433 ATSQIG-------TTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPE 1485
AT Q+G T PSIHIWDAM K TLS+LRC+HSKGV ++FSATGKLL+SVG+DPE
Sbjct: 1441 ATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPE 1500
Query: 1486 HTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKG 1545
HTIT+WRWQEGAK+ASR GH +RIFV EFRPDSDTQFVSVGVKH+KFWTLAG ALL KKG
Sbjct: 1501 HTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKG 1560
Query: 1546 VIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTL 1605
++ +L A+MQTML++AFGANNLTFTG I+GDV VWKDH L R+VA+AH GPVF MYTTL
Sbjct: 1561 LLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTL 1620
Query: 1606 RDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKD 1665
RDGLIVTGGKERP+KEGGAVKLWDQE++RCRAF+LETGQ +CVRSVCRGKGKILVGT++
Sbjct: 1621 RDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRN 1680
Query: 1666 GEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV 1725
EIIEVGEKNAA NIL++GH++G IWGLATHPS+D F+SA+ DGT R+WD+ADKK+LNKV
Sbjct: 1681 AEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKV 1740
Query: 1726 SLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1785
+LGHAAR YSP+G+MVAIGMKNGEF+ILLV+SLK+WGKKRDR+ AI DIR SPD+R+L
Sbjct: 1741 NLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYL 1800
Query: 1786 AVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVP 1845
AVGSSE++VDFYDLT G LNRI YCKDIPSFVIQMDFSAD Y+QVS+G YKR V+EVP
Sbjct: 1801 AVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVP 1860
Query: 1846 LGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGL 1905
GK + + I++ITWA+WTS+LGDEV+GIW R+A+KADVNCACV+H+G+++VTGDDFG+
Sbjct: 1861 SGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGM 1920
Query: 1906 VKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
VKLFDFPC EKFAKHKR+ GHS HVTNIRF+ D++VVS GGDDCS+FVW+C+
Sbjct: 1921 VKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 405 bits (1041), Expect = e-112
Identities = 235/607 (38%), Positives = 336/607 (55%), Gaps = 27/607 (4%)
Query: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
P C+L+LEWVYGYRG CR NLY E+VYFVA V V+Y+ E Q+ +LGHNDDI
Sbjct: 51 PSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKC 110
Query: 67 LALHPDKTLVATGQVG---KE-----PYICIWDSYNVQTVSLLK-DVHTHGVACLAFDSD 117
LA+HPD +ATGQV KE P++ IWDS ++ T+ +L V V C+ F
Sbjct: 111 LAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
Query: 118 --GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
G L +V + + +WDW K + ++ + ++ P P +++CG HI
Sbjct: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
Query: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW-KGLN-LVRTIQ 233
FWTL G +L+ ++G+F K + +LC+ + +G G++YVW KG N + + +
Sbjct: 231 FWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
Query: 234 GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVC- 290
GAH G+F + A +G + GGRD + LW +D+ + ++++ E +R+V
Sbjct: 291 GAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFG-----PVRTVAE 345
Query: 291 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVR 350
D L GT + I + V L++QGH E ELW LA HP + VT D+ V
Sbjct: 346 GHGDTLYVGTTRNSILQGSVHTGFS--LLVQGHVE-ELWGLATHPSRAQFVTCGQDKLVH 402
Query: 351 LWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
LWS H + +E+ RS F P GS LA+G G +++L V D E
Sbjct: 403 LWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQ 462
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKI---GECSKSLSFITHIDWSLDSKYLQ 467
I + FSPDG+YLAVGS+D V VY V Q +K+ G+CS SFITH+DW+ DS
Sbjct: 463 ISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFV 522
Query: 468 TNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDAN 527
TN G E L++ + K +TS + ++ + WA+ TCV G V GIW + + TDIN+V +
Sbjct: 523 TNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARS 582
Query: 528 YNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHS 587
++ +L S DDFG V LF +PC + A KY GHS+HVTNV + D L+TGG D S
Sbjct: 583 HDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTS 642
Query: 588 VFQWRFI 594
V QWR +
Sbjct: 643 VLQWRVV 649
Score = 372 bits (955), Expect = e-102
Identities = 235/620 (37%), Positives = 330/620 (53%), Gaps = 42/620 (6%)
Query: 669 REKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDD 728
R + P LKL++++GYRG DCR NL+ GE+VY +A+VAV+Y+ ++ QR YLGH+D
Sbjct: 47 RSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHND 106
Query: 729 DILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-GQHQRGVCALD 779
DI L IHP +ATGQV G+ HV WD+ +L L +L G R VC +
Sbjct: 107 DIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVG 166
Query: 780 FSAD--GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
FS G L +V + H + WDW K K+ + + + V +P L+T G
Sbjct: 167 FSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGK 226
Query: 838 KHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWK---DIL 894
HI FW GG + ++G F K + ++CV++ D+V +G + G++++W + +
Sbjct: 227 SHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRI 285
Query: 895 LLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAIKRSALSTSSKG 952
+ AHDG VF + AL G + GG+D V LW + + +
Sbjct: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVE------------- 332
Query: 953 LLLEDNPSIRAITLGHGHIL-VGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLP 1011
+ ED +R + GHG L VGT IL+ +LLVQGH+E E+WGLA HP
Sbjct: 333 -VPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVE-ELWGLATHPSRA 390
Query: 1012 ICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADT 1071
T DK + +W S H+ L R ++ R F P G LAVG G +L+++ +T
Sbjct: 391 QFVTCGQDKLVHLWS-SDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTET 449
Query: 1072 VEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS----KRVGICKGASS 1126
D+V+ H E IS + FS D G YLAV SHDN V +Y V R+G C G SS
Sbjct: 450 -HDLVAIHTDGNEQISVVSFSPD-GAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSS 507
Query: 1127 YITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGI 1186
+ITH+DW NSG E L+++ P + I + +EW T TCVLG GI
Sbjct: 508 FITHLDWAQDSSCFVTNSGDYEILYWD-PATCKQITSADAVRNMEWATATCVLGFGVFGI 566
Query: 1187 WPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRW 1246
W +D TD+NA + + D LLA+ DDFG V LFSYP A KY GHS+HVTNV +
Sbjct: 567 WSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAF 626
Query: 1247 LHNDSVLLTVGGADTALMIW 1266
L +DS+ LT GG DT+++ W
Sbjct: 627 LWDDSMALTTGGKDTSVLQW 646
Score = 320 bits (821), Expect = 7e-87
Identities = 201/609 (33%), Positives = 309/609 (50%), Gaps = 31/609 (5%)
Query: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
L L+ V+GYRG DCR NL+ L G +I++ A+ ++ ++ Q YL H DDI CL +
Sbjct: 55 LKLEWVYGYRGRDCRANLYLLPTG-EIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
Query: 1423 NQHPKYRNVVATSQIGTT-------PSIHIWDAMTKHTLSMLRC-FHSKGVNYINFSAT- 1473
HP + GTT P + IWD+++ TL +L + V + FS +
Sbjct: 114 --HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSN 171
Query: 1474 -GKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKF 1532
G LL +V +H ++VW W + KV E + V F P T ++ G H+ F
Sbjct: 172 GGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYF 231
Query: 1533 WTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKD--HFLIRLV 1590
WTL G +L ++G+ K + +L V F TG G++YVW + + + V
Sbjct: 232 WTLEGGSLSKRQGLFEK--HEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAV 289
Query: 1591 AKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECV 1649
AH G VF + LRDG +V+GG ++R V LW + + + ++E + V
Sbjct: 290 LGAHDGGVFGL-CALRDGTLVSGGGRDR------RVVLWGSDYSKLQ--EVEVPEDFGPV 340
Query: 1650 RSVCRGKGKIL-VGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASND 1708
R+V G G L VGT I++ G + ++L+ GH+E E+WGLATHPS+ F++ D
Sbjct: 341 RTVAEGHGDTLYVGTTRNSILQ-GSVHTGFSLLVQGHVE-ELWGLATHPSRAQFVTCGQD 398
Query: 1709 GTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD 1768
+W + L + AR A + P G ++A+G G +++L + + D
Sbjct: 399 KLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTD 458
Query: 1769 RKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQG-TNLNRIGYCKDIPSFVIQMDFSADG 1827
I + SPD +LAVGS ++ V Y + QG ++R+G C SF+ +D++ D
Sbjct: 459 GNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDS 518
Query: 1828 KYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNC 1887
++G Y+ + KQ+T A + + WA+ T VLG V GIW AD D+N
Sbjct: 519 SCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINA 578
Query: 1888 ACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGG 1947
+H G + + DDFG V LF +PC + A +Y GHS+HVTN+ F +DD ++TGG
Sbjct: 579 VARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGG 638
Query: 1948 DDCSVFVWR 1956
D SV WR
Sbjct: 639 KDTSVLQWR 647
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 394 bits (1013), Expect = e-109
Identities = 225/607 (37%), Positives = 342/607 (56%), Gaps = 27/607 (4%)
Query: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
P +L+LEWVYGYRG CRNNLY E VYF+A V V+YN E Q+ + GHNDD+
Sbjct: 236 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 295
Query: 67 LALHPDKTLVATGQV------GKE--PYICIWDSYNVQTVSLLK-DVHTHGVACLAFDSD 117
LA+HPD+ +ATGQV GK+ P++ IWDS + T+ ++ V C+AF
Sbjct: 296 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 355
Query: 118 --GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
G L +V + + +WDW+K + LA ++ +F + P N +V+CG H+
Sbjct: 356 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 415
Query: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW-KGLNLVR-TIQ 233
FWTL G++L K+G+F K + +LC+ ++ T +G +G+I VW KG N + +Q
Sbjct: 416 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 475
Query: 234 GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVC- 290
GAH GIF++ +G + GG+D + W +++ LR+TE + IR+V
Sbjct: 476 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 530
Query: 291 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVR 350
K D +L GT + + + + P I QGH + ELW LA+H K +T D+
Sbjct: 531 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 587
Query: 351 LWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
LW H + +E+ +S F P GS +A+G G + V V D E
Sbjct: 588 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 647
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVA---QRYKKIGECSKSLSFITHIDWSLDSKYLQ 467
+ M++SPDG++LA+GS+D + +Y V+ ++Y ++G+CS SFITH+DWS++S++L
Sbjct: 648 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 707
Query: 468 TNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDAN 527
+N G E L++ + K + S E + I WA++TC G V G+WP+ ++ TDIN+V
Sbjct: 708 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 767
Query: 528 YNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHS 587
+ +L +GDDFG V LF +PC + A Y GHS+HVTNV + + ++STGG D S
Sbjct: 768 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 827
Query: 588 VFQWRFI 594
+ QWR I
Sbjct: 828 IMQWRVI 834
Score = 354 bits (908), Expect = 5e-97
Identities = 231/690 (33%), Positives = 347/690 (50%), Gaps = 46/690 (6%)
Query: 599 SNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSK 658
SNG G+ S S + P+ +E + +++ P K
Sbjct: 166 SNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYV----KMFLRGRPVTMYMPK 221
Query: 659 EKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQH 718
++ + + + P LKL++++GYRG DCRNNL+ GE VY IA+V V+YN ++
Sbjct: 222 DQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQ 281
Query: 719 SQRLYLGHDDDILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-G 769
QR Y GH+DD+ L +HP + +ATGQV G+ HV WD+ TL L ++ G
Sbjct: 282 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 341
Query: 770 QHQRGVCALDFSAD--GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPH 827
R V + FS G L +V + H + WDW+K EK+A + + +F +P
Sbjct: 342 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 401
Query: 828 HVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDI 887
+ +VT G H+ FW G K+G F K + ++CV++ D + +G ++G+I
Sbjct: 402 DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNI 460
Query: 888 FIW---KDILLLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAIK 942
+W + + AH+G +FA+ L G + GGKD + W +++ KT
Sbjct: 461 LVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE--- 517
Query: 943 RSALSTSSKGLLLEDNPSIRAITLGHGH-ILVGTKNGEILEIDKSGPMTLLVQGHMEGEV 1001
+ E IR + G G IL+GT +L+ SG T + QGH + E+
Sbjct: 518 -----------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD-EL 565
Query: 1002 WGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLND 1061
WGLA H T DK +W+ + HR + + ++ + F P G +AVG
Sbjct: 566 WGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLT 624
Query: 1062 GSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS----K 1116
G + V + +T +D+V+ H E +S +++S D G +LA+ SHDN + IY V +
Sbjct: 625 GRWFVFDTET-KDLVTVHTDGNEQLSVMRYSPD-GNFLAIGSHDNCIYIYGVSDNGRKYT 682
Query: 1117 RVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWT 1176
RVG C G SS+ITH+DW + L NSG E L++ P + ++ IEW T+T
Sbjct: 683 RVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYT 741
Query: 1177 CVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVG 1236
C LG G+WP SD TD+NA + LL+TGDDFG V LFSYP A Y G
Sbjct: 742 CTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGG 801
Query: 1237 HSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
HS+HVTNV +L DS L++ GG DT++M W
Sbjct: 802 HSSHVTNVDFLCEDSHLISTGGKDTSIMQW 831
Score = 321 bits (822), Expect = 5e-87
Identities = 204/638 (31%), Positives = 320/638 (50%), Gaps = 33/638 (5%)
Query: 1337 PVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAA 1396
PV+ P+ + + K + + L L+ V+GYRG DCRNNL+ L G + F A+
Sbjct: 214 PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYF-IASV 272
Query: 1397 GIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT--------PSIHIWDA 1448
++ N+ Q Y H DD+ CL V HP R +AT Q+ T P + IWD+
Sbjct: 273 VVLYNVEEQLQRHYAGHNDDVKCLAV--HPD-RITIATGQVAGTSKDGKQLPPHVRIWDS 329
Query: 1449 MTKHTLSMLRC-FHSKGVNYINFSAT--GKLLVSVGVDPEHTITVWRWQEGAKVASRGGH 1505
+T +TL ++ F + V I FS + G L +V +H ++VW WQ+ K+A
Sbjct: 330 VTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCS 389
Query: 1506 LERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGA 1565
E +F +F P V+ G H+ FWTL GS+L K+G+ K + +L V F
Sbjct: 390 NEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEK--QEKPKFVLCVTFSE 447
Query: 1566 NNLTFTGAINGDVYVWKD--HFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEG 1622
N T TG +G++ VW + + V AH G +F + LRDG +V+GG K+R
Sbjct: 448 NGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL-CMLRDGTLVSGGGKDRKLIS- 505
Query: 1623 GAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGK-ILVGTKDGEIIEVGEKNAASNIL 1681
W ++ R + E + +R+V GKG IL+GT +++ G + +
Sbjct: 506 -----WSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQ-GTLSGDFTPI 557
Query: 1682 IDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGE 1741
GH + E+WGLA H SK F++ +D A +WD + + + A+ + + P G
Sbjct: 558 TQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGS 616
Query: 1742 MVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ 1801
+VA+G G + + + + D + +R SPD FLA+GS ++ + Y ++
Sbjct: 617 VVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSD 676
Query: 1802 -GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT 1860
G R+G C SF+ +D+S + +++ ++G Y+ KQV I
Sbjct: 677 NGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIE 736
Query: 1861 WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH 1920
WA++T LG V G+WP +D D+N C H + TGDDFG V LF +PC++ A
Sbjct: 737 WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPS 796
Query: 1921 KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
Y GHS+HVTN+ F +D +++STGG D S+ WR +
Sbjct: 797 HIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 394 bits (1013), Expect = e-109
Identities = 225/607 (37%), Positives = 342/607 (56%), Gaps = 27/607 (4%)
Query: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
P +L+LEWVYGYRG CRNNLY E VYF+A V V+YN E Q+ + GHNDD+
Sbjct: 217 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 276
Query: 67 LALHPDKTLVATGQV------GKE--PYICIWDSYNVQTVSLLK-DVHTHGVACLAFDSD 117
LA+HPD+ +ATGQV GK+ P++ IWDS + T+ ++ V C+AF
Sbjct: 277 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 336
Query: 118 --GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
G L +V + + +WDW+K + LA ++ +F + P N +V+CG H+
Sbjct: 337 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 396
Query: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW-KGLNLVR-TIQ 233
FWTL G++L K+G+F K + +LC+ ++ T +G +G+I VW KG N + +Q
Sbjct: 397 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 456
Query: 234 GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVC- 290
GAH GIF++ +G + GG+D + W +++ LR+TE + IR+V
Sbjct: 457 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 511
Query: 291 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVR 350
K D +L GT + + + + P I QGH + ELW LA+H K +T D+
Sbjct: 512 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 568
Query: 351 LWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
LW H + +E+ +S F P GS +A+G G + V V D E
Sbjct: 569 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 628
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVA---QRYKKIGECSKSLSFITHIDWSLDSKYLQ 467
+ M++SPDG++LA+GS+D + +Y V+ ++Y ++G+CS SFITH+DWS++S++L
Sbjct: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
Query: 468 TNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDAN 527
+N G E L++ + K + S E + I WA++TC G V G+WP+ ++ TDIN+V
Sbjct: 689 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 748
Query: 528 YNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHS 587
+ +L +GDDFG V LF +PC + A Y GHS+HVTNV + + ++STGG D S
Sbjct: 749 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 808
Query: 588 VFQWRFI 594
+ QWR I
Sbjct: 809 IMQWRVI 815
Score = 354 bits (908), Expect = 5e-97
Identities = 231/690 (33%), Positives = 347/690 (50%), Gaps = 46/690 (6%)
Query: 599 SNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSK 658
SNG G+ S S + P+ +E + +++ P K
Sbjct: 147 SNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYV----KMFLRGRPVTMYMPK 202
Query: 659 EKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQH 718
++ + + + P LKL++++GYRG DCRNNL+ GE VY IA+V V+YN ++
Sbjct: 203 DQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQ 262
Query: 719 SQRLYLGHDDDILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-G 769
QR Y GH+DD+ L +HP + +ATGQV G+ HV WD+ TL L ++ G
Sbjct: 263 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
Query: 770 QHQRGVCALDFSAD--GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPH 827
R V + FS G L +V + H + WDW+K EK+A + + +F +P
Sbjct: 323 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 382
Query: 828 HVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDI 887
+ +VT G H+ FW G K+G F K + ++CV++ D + +G ++G+I
Sbjct: 383 DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNI 441
Query: 888 FIW---KDILLLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAIK 942
+W + + AH+G +FA+ L G + GGKD + W +++ KT
Sbjct: 442 LVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE--- 498
Query: 943 RSALSTSSKGLLLEDNPSIRAITLGHGH-ILVGTKNGEILEIDKSGPMTLLVQGHMEGEV 1001
+ E IR + G G IL+GT +L+ SG T + QGH + E+
Sbjct: 499 -----------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD-EL 546
Query: 1002 WGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLND 1061
WGLA H T DK +W+ + HR + + ++ + F P G +AVG
Sbjct: 547 WGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLT 605
Query: 1062 GSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS----K 1116
G + V + +T +D+V+ H E +S +++S D G +LA+ SHDN + IY V +
Sbjct: 606 GRWFVFDTET-KDLVTVHTDGNEQLSVMRYSPD-GNFLAIGSHDNCIYIYGVSDNGRKYT 663
Query: 1117 RVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWT 1176
RVG C G SS+ITH+DW + L NSG E L++ P + ++ IEW T+T
Sbjct: 664 RVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYT 722
Query: 1177 CVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVG 1236
C LG G+WP SD TD+NA + LL+TGDDFG V LFSYP A Y G
Sbjct: 723 CTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGG 782
Query: 1237 HSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
HS+HVTNV +L DS L++ GG DT++M W
Sbjct: 783 HSSHVTNVDFLCEDSHLISTGGKDTSIMQW 812
Score = 321 bits (822), Expect = 5e-87
Identities = 204/638 (31%), Positives = 320/638 (50%), Gaps = 33/638 (5%)
Query: 1337 PVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAA 1396
PV+ P+ + + K + + L L+ V+GYRG DCRNNL+ L G + F A+
Sbjct: 195 PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYF-IASV 253
Query: 1397 GIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT--------PSIHIWDA 1448
++ N+ Q Y H DD+ CL V HP R +AT Q+ T P + IWD+
Sbjct: 254 VVLYNVEEQLQRHYAGHNDDVKCLAV--HPD-RITIATGQVAGTSKDGKQLPPHVRIWDS 310
Query: 1449 MTKHTLSMLRC-FHSKGVNYINFSAT--GKLLVSVGVDPEHTITVWRWQEGAKVASRGGH 1505
+T +TL ++ F + V I FS + G L +V +H ++VW WQ+ K+A
Sbjct: 311 VTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCS 370
Query: 1506 LERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGA 1565
E +F +F P V+ G H+ FWTL GS+L K+G+ K + +L V F
Sbjct: 371 NEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEK--QEKPKFVLCVTFSE 428
Query: 1566 NNLTFTGAINGDVYVWKD--HFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEG 1622
N T TG +G++ VW + + V AH G +F + LRDG +V+GG K+R
Sbjct: 429 NGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL-CMLRDGTLVSGGGKDRKLIS- 486
Query: 1623 GAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGK-ILVGTKDGEIIEVGEKNAASNIL 1681
W ++ R + E + +R+V GKG IL+GT +++ G + +
Sbjct: 487 -----WSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQ-GTLSGDFTPI 538
Query: 1682 IDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGE 1741
GH + E+WGLA H SK F++ +D A +WD + + + A+ + + P G
Sbjct: 539 TQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGS 597
Query: 1742 MVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ 1801
+VA+G G + + + + D + +R SPD FLA+GS ++ + Y ++
Sbjct: 598 VVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSD 657
Query: 1802 -GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT 1860
G R+G C SF+ +D+S + +++ ++G Y+ KQV I
Sbjct: 658 NGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIE 717
Query: 1861 WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH 1920
WA++T LG V G+WP +D D+N C H + TGDDFG V LF +PC++ A
Sbjct: 718 WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPS 777
Query: 1921 KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
Y GHS+HVTN+ F +D +++STGG D S+ WR +
Sbjct: 778 HIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 384 bits (987), Expect = e-106
Identities = 230/691 (33%), Positives = 364/691 (52%), Gaps = 47/691 (6%)
Query: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
P +L+LEW YGYRG CR N+Y E+VYF+A V V++N E +Q+ +LGH D +
Sbjct: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 256
Query: 67 LALHPDKTLVATGQVGK--------EPYICIWDSYNVQTVSLLK-DVHTHGVACLAFDS- 116
LA+HPDK +ATGQ+ +P++ +WDS + T+ ++ GV CL F
Sbjct: 257 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 316
Query: 117 -DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
G L + ++ + +WDW+K A ++ + + + P N +++CG HI
Sbjct: 317 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 376
Query: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW------------ 223
FWT GN+LT K+GIFGK + + CLA +G G + +W
Sbjct: 377 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 436
Query: 224 -KGLNLVRTIQGAHSAGIFSMYACEEGFAT--GGRDGCIRLWDTDFKPITKIDLRETEQG 280
KG+ + AH +F++ G GG+D I LWD D P +I++ + + G
Sbjct: 437 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPD-QYG 495
Query: 281 YKGLSIRSVC-WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPL 339
+IR+V KAD+ L GT + I D + +QGH + ELW LA HP K L
Sbjct: 496 ----TIRAVAEGKADQFLVGTSRNFILRGTFN--DGFQIEVQGHTD-ELWGLATHPFKDL 548
Query: 340 AVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMT 399
+T + DR V LW+ +H L ++E F P G+ +A+G G + VL
Sbjct: 549 LLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRD 608
Query: 400 EVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ---RYKKIGECSKSLSFITH 456
V D E + M++S DG++LAVGS+D + +Y V++ +Y + G C+ S+ITH
Sbjct: 609 LVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITH 668
Query: 457 IDWSLDSKYLQTNDGAGERLFYRMPSG-KPLTSKEEIKGIPWASWTCVKGPEVSGIWPKY 515
+DWS D+KY+ +N G E L++ +P+G K + ++ + K I W ++TCV G +V G+WP+
Sbjct: 669 LDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEG 728
Query: 516 TEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDF 575
++ TDIN++ ++N V+ DDF V LF++PC K A KY HS+HVTNV ++H+
Sbjct: 729 SDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHND 788
Query: 576 QWVLSTGGADHSVFQWRFIP-------EGVSNGMLETAPQEGGADSYSEESDSDLSDVPE 628
++STGG D S+ QW+ + E V++ L AP + + P
Sbjct: 789 SHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP- 847
Query: 629 LDSDIEQEAQINYDRQVYKEDLPQLKQQSKE 659
L+ E+E++I+ + + L Q + S++
Sbjct: 848 LNETAEEESRISSSPTLLENSLEQTVEPSED 878
Score = 371 bits (952), Expect = e-102
Identities = 228/631 (36%), Positives = 335/631 (53%), Gaps = 52/631 (8%)
Query: 669 REKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDD 728
R + P + LKL++ +GYRG DCR N++ GE+VY IA+V V++N ++ +QR YLGH D
Sbjct: 193 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 252
Query: 729 DILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-GQHQRGVCALD 779
+ L IHP K +ATGQ+ GR HV WD+ TL L ++ G +RGV LD
Sbjct: 253 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
Query: 780 FSADGKCLVSVGLDDF--HSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
FS + +DD H + WDW+K K A + + + V+ +P + ++T G
Sbjct: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
Query: 838 KHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDIL--- 894
HI FW +G T K+G FG K + + C+++ D V +G + G + IW
Sbjct: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGD-VLTGDSGGVMLIWSKTTVEP 431
Query: 895 -----------LLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAI 941
+ K +KAHDG VF + + G + GGKD + LWD
Sbjct: 432 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH----------- 480
Query: 942 KRSALSTSSKGLLLEDNPSIRAITLGHG-HILVGTKNGEILEIDKSGPMTLLVQGHMEGE 1000
L+ + + + +IRA+ G LVGT IL + + VQGH + E
Sbjct: 481 ---DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 536
Query: 1001 VWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLN 1060
+WGLA HP + T + D+ + +W S +HR+ R + + G C F P G +A+G +
Sbjct: 537 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 595
Query: 1061 DGSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS---- 1115
G + V++A+T D+VS H E +S +++S D G +LAV SHDNF+ +Y V +
Sbjct: 596 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSID-GTFLAVGSHDNFIYLYVVSENGRKY 653
Query: 1116 KRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTW 1175
R G C G SSYITH+DW K + NSG E L+++ P G + I S+ + I+W T+
Sbjct: 654 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
Query: 1176 TCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYV 1235
TCVLG G+WP SD TD+NA + + ++A DDF V LF YP A KY
Sbjct: 714 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 773
Query: 1236 GHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
HS+HVTNV + HNDS L++ GG D +++ W
Sbjct: 774 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 804
Score = 316 bits (809), Expect = 2e-85
Identities = 204/625 (32%), Positives = 319/625 (51%), Gaps = 47/625 (7%)
Query: 1361 EELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCL 1420
E+L L+ +GYRG DCR N++ L G +I++ A+ ++ N +Q YL HTD + CL
Sbjct: 199 EKLKLEWAYGYRGKDCRANVYLLPTG-EIVYFIASVVVLFNYEERTQRHYLGHTDCVKCL 257
Query: 1421 TVNQHP-KYRNVVATSQIGTT--------PSIHIWDAMTKHTLSMLRC-FHSKGVNYINF 1470
+ HP K R +AT QI P + +WD++T TL ++ +GV ++F
Sbjct: 258 AI--HPDKIR--IATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDF 313
Query: 1471 SA--TGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVK 1528
S +G L + EH +TVW WQ+ AK A E + VEF P ++ G
Sbjct: 314 SKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKS 373
Query: 1529 HMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW------- 1581
H+ FWT +G++L K+G+ G K L AF N TG G + +W
Sbjct: 374 HIFFWTWSGNSLTRKQGIFGKYEKPKFVQCL--AFLGNGDVLTGDSGGVMLIWSKTTVEP 431
Query: 1582 ------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEGGAVKLWDQEMKR 1634
K + I KAH G VFT+ +R+G+++TGG K+R + LWD ++
Sbjct: 432 TPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLNP 484
Query: 1635 CRAFQLETGQLVECVRSVCRGKG-KILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGL 1693
R ++E +R+V GK + LVGT I+ G N I + GH + E+WGL
Sbjct: 485 ER--EIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWGL 540
Query: 1694 ATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFV 1753
ATHP KDL ++ + D +W+ + +L + CA + P G +VAIG +G +
Sbjct: 541 ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF 600
Query: 1754 ILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ-GTNLNRIGYCK 1812
+L + + D + +R S D FLAVGS ++ + Y +++ G +R G C
Sbjct: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT 660
Query: 1813 DIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLG-KQVTEAVVIEKITWASWTSVLGDE 1871
S++ +D+S D KYI ++G Y+ ++P G K + + I W ++T VLG +
Sbjct: 661 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 720
Query: 1872 VIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVT 1931
V G+WP +D D+N +H I DDF V LF +PC++ A +Y HS+HVT
Sbjct: 721 VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT 780
Query: 1932 NIRFSYDDKYVVSTGGDDCSVFVWR 1956
N+ F+++D +++STGG D S+ W+
Sbjct: 781 NVSFTHNDSHLISTGGKDMSIIQWK 805
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 384 bits (987), Expect = e-106
Identities = 230/691 (33%), Positives = 364/691 (52%), Gaps = 47/691 (6%)
Query: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
P +L+LEW YGYRG CR N+Y E+VYF+A V V++N E +Q+ +LGH D +
Sbjct: 255 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 314
Query: 67 LALHPDKTLVATGQVGK--------EPYICIWDSYNVQTVSLLK-DVHTHGVACLAFDS- 116
LA+HPDK +ATGQ+ +P++ +WDS + T+ ++ GV CL F
Sbjct: 315 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 374
Query: 117 -DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
G L + ++ + +WDW+K A ++ + + + P N +++CG HI
Sbjct: 375 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 434
Query: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW------------ 223
FWT GN+LT K+GIFGK + + CLA +G G + +W
Sbjct: 435 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 494
Query: 224 -KGLNLVRTIQGAHSAGIFSMYACEEGFAT--GGRDGCIRLWDTDFKPITKIDLRETEQG 280
KG+ + AH +F++ G GG+D I LWD D P +I++ + + G
Sbjct: 495 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPD-QYG 553
Query: 281 YKGLSIRSVC-WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPL 339
+IR+V KAD+ L GT + I D + +QGH + ELW LA HP K L
Sbjct: 554 ----TIRAVAEGKADQFLVGTSRNFILRGTFN--DGFQIEVQGHTD-ELWGLATHPFKDL 606
Query: 340 AVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMT 399
+T + DR V LW+ +H L ++E F P G+ +A+G G + VL
Sbjct: 607 LLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRD 666
Query: 400 EVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ---RYKKIGECSKSLSFITH 456
V D E + M++S DG++LAVGS+D + +Y V++ +Y + G C+ S+ITH
Sbjct: 667 LVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITH 726
Query: 457 IDWSLDSKYLQTNDGAGERLFYRMPSG-KPLTSKEEIKGIPWASWTCVKGPEVSGIWPKY 515
+DWS D+KY+ +N G E L++ +P+G K + ++ + K I W ++TCV G +V G+WP+
Sbjct: 727 LDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEG 786
Query: 516 TEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDF 575
++ TDIN++ ++N V+ DDF V LF++PC K A KY HS+HVTNV ++H+
Sbjct: 787 SDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHND 846
Query: 576 QWVLSTGGADHSVFQWRFIP-------EGVSNGMLETAPQEGGADSYSEESDSDLSDVPE 628
++STGG D S+ QW+ + E V++ L AP + + P
Sbjct: 847 SHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP- 905
Query: 629 LDSDIEQEAQINYDRQVYKEDLPQLKQQSKE 659
L+ E+E++I+ + + L Q + S++
Sbjct: 906 LNETAEEESRISSSPTLLENSLEQTVEPSED 936
Score = 371 bits (952), Expect = e-102
Identities = 228/631 (36%), Positives = 335/631 (53%), Gaps = 52/631 (8%)
Query: 669 REKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDD 728
R + P + LKL++ +GYRG DCR N++ GE+VY IA+V V++N ++ +QR YLGH D
Sbjct: 251 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 310
Query: 729 DILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-GQHQRGVCALD 779
+ L IHP K +ATGQ+ GR HV WD+ TL L ++ G +RGV LD
Sbjct: 311 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 370
Query: 780 FSADGKCLVSVGLDDF--HSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
FS + +DD H + WDW+K K A + + + V+ +P + ++T G
Sbjct: 371 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 430
Query: 838 KHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDIL--- 894
HI FW +G T K+G FG K + + C+++ D V +G + G + IW
Sbjct: 431 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGD-VLTGDSGGVMLIWSKTTVEP 489
Query: 895 -----------LLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAI 941
+ K +KAHDG VF + + G + GGKD + LWD
Sbjct: 490 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH----------- 538
Query: 942 KRSALSTSSKGLLLEDNPSIRAITLGHG-HILVGTKNGEILEIDKSGPMTLLVQGHMEGE 1000
L+ + + + +IRA+ G LVGT IL + + VQGH + E
Sbjct: 539 ---DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 594
Query: 1001 VWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLN 1060
+WGLA HP + T + D+ + +W S +HR+ R + + G C F P G +A+G +
Sbjct: 595 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 653
Query: 1061 DGSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS---- 1115
G + V++A+T D+VS H E +S +++S D G +LAV SHDNF+ +Y V +
Sbjct: 654 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSID-GTFLAVGSHDNFIYLYVVSENGRKY 711
Query: 1116 KRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTW 1175
R G C G SSYITH+DW K + NSG E L+++ P G + I S+ + I+W T+
Sbjct: 712 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 771
Query: 1176 TCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYV 1235
TCVLG G+WP SD TD+NA + + ++A DDF V LF YP A KY
Sbjct: 772 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 831
Query: 1236 GHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
HS+HVTNV + HNDS L++ GG D +++ W
Sbjct: 832 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 862
Score = 316 bits (809), Expect = 2e-85
Identities = 204/625 (32%), Positives = 319/625 (51%), Gaps = 47/625 (7%)
Query: 1361 EELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCL 1420
E+L L+ +GYRG DCR N++ L G +I++ A+ ++ N +Q YL HTD + CL
Sbjct: 257 EKLKLEWAYGYRGKDCRANVYLLPTG-EIVYFIASVVVLFNYEERTQRHYLGHTDCVKCL 315
Query: 1421 TVNQHP-KYRNVVATSQIGTT--------PSIHIWDAMTKHTLSMLRC-FHSKGVNYINF 1470
+ HP K R +AT QI P + +WD++T TL ++ +GV ++F
Sbjct: 316 AI--HPDKIR--IATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDF 371
Query: 1471 SA--TGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVK 1528
S +G L + EH +TVW WQ+ AK A E + VEF P ++ G
Sbjct: 372 SKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKS 431
Query: 1529 HMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW------- 1581
H+ FWT +G++L K+G+ G K L AF N TG G + +W
Sbjct: 432 HIFFWTWSGNSLTRKQGIFGKYEKPKFVQCL--AFLGNGDVLTGDSGGVMLIWSKTTVEP 489
Query: 1582 ------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEGGAVKLWDQEMKR 1634
K + I KAH G VFT+ +R+G+++TGG K+R + LWD ++
Sbjct: 490 TPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLNP 542
Query: 1635 CRAFQLETGQLVECVRSVCRGKG-KILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGL 1693
R ++E +R+V GK + LVGT I+ G N I + GH + E+WGL
Sbjct: 543 ER--EIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWGL 598
Query: 1694 ATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFV 1753
ATHP KDL ++ + D +W+ + +L + CA + P G +VAIG +G +
Sbjct: 599 ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF 658
Query: 1754 ILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ-GTNLNRIGYCK 1812
+L + + D + +R S D FLAVGS ++ + Y +++ G +R G C
Sbjct: 659 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT 718
Query: 1813 DIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLG-KQVTEAVVIEKITWASWTSVLGDE 1871
S++ +D+S D KYI ++G Y+ ++P G K + + I W ++T VLG +
Sbjct: 719 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 778
Query: 1872 VIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVT 1931
V G+WP +D D+N +H I DDF V LF +PC++ A +Y HS+HVT
Sbjct: 779 VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT 838
Query: 1932 NIRFSYDDKYVVSTGGDDCSVFVWR 1956
N+ F+++D +++STGG D S+ W+
Sbjct: 839 NVSFTHNDSHLISTGGKDMSIIQWK 863
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 323 bits (829), Expect = 8e-88
Identities = 217/642 (33%), Positives = 319/642 (49%), Gaps = 66/642 (10%)
Query: 673 PEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQH-------SQRLYLG 725
P ++L L +++GYRG D R+NLF ++GEVVY IA V V+Y QR Y G
Sbjct: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
Query: 726 HDDDILSLTIHPVKDYVATGQ---VGRDA-----AIHVWDTQTL-KCLSLLKGQHQRGVC 776
H D + L +HP VA+GQ V +D +H+WD++TL K + G +RGV
Sbjct: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
Query: 777 ALDFSA--DGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVT 834
AL FSA G L V + H + WD +G K+A + D + V NP +VT
Sbjct: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
Query: 835 VGIKHIKFWQQAGG-------GFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDI 887
G H+ FW +GG T K+G FG K + + C + D++ +G + G+I
Sbjct: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDIL-TGDSEGNI 482
Query: 888 FIW----------------KDILLLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWD 929
W + ++ AH+G +FA+ G V GG+D + W
Sbjct: 483 LTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWG 542
Query: 930 DMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITLGHG-HILVGTKNGEILEIDKSGP 988
L + + E ++RAI G G +LVGT +L D +
Sbjct: 543 P--------------GLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG 588
Query: 989 MTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAF 1048
+ ++QGH + E+WGL HP T D+ L +W+ H + LK+ G C F
Sbjct: 589 FSPVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWD-GESHALAWSIDLKETGLCADF 646
Query: 1049 SPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVD 1108
P G +AVGLN G +LV++ +T E + E +S +++S D G YLA+ SHDN +
Sbjct: 647 HPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPD-GLYLAIGSHDNVIY 705
Query: 1109 IYNVLT----SKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRP 1164
IY+V + S R G C G SS+ITH+DW G + NSG E L+++ G + +
Sbjct: 706 IYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNR 765
Query: 1165 SEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPV 1224
E EW T+TCVLG G+WP SD TD+N+ + + ++A DDF V LF YP
Sbjct: 766 YESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPC 825
Query: 1225 KGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
A + Y GH +HVT+VR+ H+DS L+++GG D ++ W
Sbjct: 826 ARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
Score = 315 bits (807), Expect = 3e-85
Identities = 205/637 (32%), Positives = 317/637 (49%), Gaps = 61/637 (9%)
Query: 11 LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREH-------SQKFFLGHNDD 63
L L+WVYGYRG R+NL+ EVVYF+A V V+Y Q+ + GH D
Sbjct: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDC 307
Query: 64 IISLALHPDKTLVATGQV------GK--EPYICIWDSYNVQTVSLLKDV----HTHGVAC 111
+ LA+HPD VA+GQ GK +P + IWDS +T+ L+++ GV
Sbjct: 308 VRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDS---ETLLKLQEIGLGAFERGVGA 364
Query: 112 LAFDS--DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSC 169
LAF + G L V ++ + +WD +G LA +D + + ++P + +V+
Sbjct: 365 LAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTS 424
Query: 170 GVKHIKFWTLCGNA-------LTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYV 222
G H+ FW G LT K+G+FGK + I C + +G G+I
Sbjct: 425 GKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILT 484
Query: 223 W---------KGLNLVRTIQG------AHSAGIFSMYACEEG--FATGGRDGCIRLWDTD 265
W G + G AH IF++ +G + GGRD + W
Sbjct: 485 WGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPG 544
Query: 266 FKPITKIDLRETEQGYKGLSIRSVC-WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHC 324
+ L+E E ++R++ LL GT + + + + P ++QGH
Sbjct: 545 L-----VALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP--VIQGHT 597
Query: 325 EGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALG 384
+ ELW L HP + +T DR + LW HAL +++E F P G+ +A+G
Sbjct: 598 D-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVG 656
Query: 385 MKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ---RY 441
+ G ++VL V + D E + +++SPDG YLA+GS+D + +Y+V+ +
Sbjct: 657 LNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKS 716
Query: 442 KKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSG-KPLTSKEEIKGIPWASW 500
+ G C SFITH+DWS D ++ +N G E L++ + G K L ++ E + WA++
Sbjct: 717 SRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATY 776
Query: 501 TCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYV 560
TCV G V G+WP ++ TDINS+ ++N V+ DDF V LF++PC + A R Y
Sbjct: 777 TCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYG 836
Query: 561 GHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEG 597
GH +HVT+VR++HD ++S GG D S+FQWR + G
Sbjct: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAG 873
Score = 283 bits (723), Expect = 2e-75
Identities = 194/640 (30%), Positives = 297/640 (46%), Gaps = 57/640 (8%)
Query: 1361 EELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQ------NLSTGSQSFYLEHT 1414
E L+LD V+GYRG D R+NL L G + F + + G Q Y HT
Sbjct: 246 ETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHT 305
Query: 1415 DDILCLTVNQHPKYRNVVATSQIGTT-------PSIHIWDAMTKHTLSMLRC-FHSKGVN 1466
D + CL V HP V + G P +HIWD+ T L + +GV
Sbjct: 306 DCVRCLAV--HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
Query: 1467 YINFSAT--GKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVS 1524
+ FSA G L V EH ++VW G K+A + + V F P + V+
Sbjct: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
Query: 1525 VGVKHMKFWTLAGSA-------LLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGD 1577
G H+ FW +G L K+GV G K + F + TG G+
Sbjct: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKF--IPCFVFLPDGDILTGDSEGN 481
Query: 1578 VYVW---------------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKE 1621
+ W K+ + I A AH G +F + RDG +++GG ++R +
Sbjct: 482 ILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR-RDGTVLSGGGRDRRLVQ 540
Query: 1622 GGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKG-KILVGTKDGEIIEVGEKNAASNI 1680
G + QE E + VR++ G G ++LVGT ++ G+ +
Sbjct: 541 WGPGLVALQEA--------EIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFSP 591
Query: 1681 LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG 1740
+I GH + E+WGL THPS++ F++ +D +WD L + L CA + P G
Sbjct: 592 VIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSG 650
Query: 1741 EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
+VA+G+ G +++L + ++ D + +R SPD +LA+GS ++ + Y ++
Sbjct: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVS 710
Query: 1801 Q-GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLG-KQVTEAVVIEK 1858
G +R G C SF+ +D+S DG +I ++G Y+ +V G KQ+
Sbjct: 711 SDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRD 770
Query: 1859 ITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFA 1918
WA++T VLG V G+WP +D D+N C +H + DDF V LF +PC A
Sbjct: 771 REWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKA 830
Query: 1919 KHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
+ Y GH +HVT++RF++DD ++VS GG D S+F WR L
Sbjct: 831 PSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 179 bits (453), Expect = 3e-44
Identities = 302/1239 (24%), Positives = 480/1239 (38%), Gaps = 176/1239 (14%)
Query: 11 LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALH 70
LRL+ V G+ GH R L+ G VVY V VV Q+FFLGH D + +LAL
Sbjct: 359 LRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALD 418
Query: 71 PDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKN 130
+L+A+ Q + +WD + + L + H V L+F G L VG D
Sbjct: 419 GSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-MHVVCSLSFSDSGALLCGVGKDHHG 477
Query: 131 TVCIWDWRKGKL------LASATGHSD---RIFDISWDPYQPNRVVSCGVKHIKFWTLCG 181
+ W G++ + A H+D + F +++ + R+ SCG ++ W L G
Sbjct: 478 RTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTF--FDETRMASCGQGSVRLWRLRG 535
Query: 182 NALTAKRGIFGKTGDLQ-TILCLACAKEDITYSGAL-------NGDIYVWKGLNLV---- 229
L + G+ LQ T L A++ A +G I +V
Sbjct: 536 GVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHA 595
Query: 230 ------RTIQGAH------SAG----IFSMYACEEGFATGGRDGCIRLWDTDFKPITKID 273
RT G H S+G I S+ A G DG +RLW DF +
Sbjct: 596 RRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSV---- 651
Query: 274 LRETEQGYKGLSIRSVCWKAD--RLLAGTQD---------SEIFEVIVRERDKPMLIL-Q 321
L E E ++G + SVC D R+L+ T S ++ ++ R P+L L
Sbjct: 652 LLEAE--HEG-PVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAM 708
Query: 322 GHCEGEL-----------WALA-------------------LHPKKPLAVTGSDDRSVRL 351
G+L W LA HP +P G +VR
Sbjct: 709 EQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRS 768
Query: 352 WSL-ADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
+SL A L+ AV + +PDG L GS D V V
Sbjct: 769 FSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMV 828
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTND 470
+ SP S LAV S DG + + R S SL + +D D
Sbjct: 829 CPDAPASP--SALAV-SRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLD 885
Query: 471 GAGERLFYRMPSGKPL--TSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANY 528
A F G L TS + + S ++ E+ G+ P+ + S DA +
Sbjct: 886 SAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIR--ELPGVHPEPCPSLTL-SEDARF 942
Query: 529 NSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSV 588
+L++ +K++ + + + Y+GHS V V +S D Q VLS G A V
Sbjct: 943 ---LLIAAGR--TIKVWDY-ATQASPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDA---V 993
Query: 589 FQWRFIPEGVSNGMLETAP---QEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQV 645
F W + S+ AP + G E++ S S++P + + Q + R
Sbjct: 994 FLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPR--QQVPKPCQASPPRLG 1051
Query: 646 YKEDLPQLKQQSKE-KNHAVP---FLKREKA------------------PEDS---LKLQ 680
P+ +++ +N P +L KA P S L+L+
Sbjct: 1052 VCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPASGGWLRLK 1111
Query: 681 FIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKD 740
+ GY G N ++ G Y + VV + +Q+ + GH +I +L +
Sbjct: 1112 AVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQ 1171
Query: 741 YVATGQVGRDAA-----IHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDF 795
+A+ GR + I VWD C L+ H V AL FS D + LV++G D
Sbjct: 1172 VLASAS-GRSSTTAHCQIRVWDVSGGLCQHLIF-PHSTTVLALAFSPDDRLLVTLGDHDG 1229
Query: 796 HSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFW--QQAGGGFT-- 851
++ W + +++TR + + V NP +L VG + FW QQ G +
Sbjct: 1230 RTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQ 1288
Query: 852 -SKRGTFGSVGKLE-TMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTVKAHDGPVF 907
+ +VG E T +C YG L++ G ++G + +W + + +A DG +
Sbjct: 1289 VRREPVPEAVGAGELTSLC--YG-APPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIG 1345
Query: 908 AMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRA---- 963
+ V+G G + LW L+ A S + L+ D + A
Sbjct: 1346 LLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKG--SGASSVFMEHELVLDGAVVSASFDD 1403
Query: 964 -ITLGHGHILVGTKNGEILEID-KSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKT 1021
+ +G +VGT G + + G T L+ GH +V + P CAT S+D +
Sbjct: 1404 SVDMG----VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHCATCSEDGS 1458
Query: 1022 LRIWELSAQHRMLAVRKLKKGGRCCAFS------PDGKALAVGLNDGSFLVVNADTVEDM 1075
+R+W L++ ++ + L + C A+S P+ + LA G DGS + +
Sbjct: 1459 VRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAME 1518
Query: 1076 VSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLT 1114
+ H ++ + FS D G+ + D V + + T
Sbjct: 1519 LKMHPHPVALTTVAFSTD-GQTVLSGDKDGLVAVSHPCT 1556
Score = 85.9 bits (211), Expect = 4e-16
Identities = 120/542 (22%), Positives = 202/542 (37%), Gaps = 65/542 (11%)
Query: 595 PEGVSNGMLETAPQEGGADSYSEE-SDSDLSDVPELDSDIEQEAQINY-DRQVYKEDLPQ 652
P ++G AP+ S S+E SD+ +D P S +E AQ+ D
Sbjct: 276 PSPTASGRAALAPRPFPEVSLSQERSDASNADGPGFHS-LEPWAQLEASDIHTAAAGTHV 334
Query: 653 LKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVV 712
L +S E A P+ L+L+ + G+ G+ R L+ VVY AV VV
Sbjct: 335 LTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVV 394
Query: 713 YNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQ 772
QR +LGH D + +L + +A+ Q + + +WD QT +CL L +
Sbjct: 395 LLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-M 453
Query: 773 RGVCALDFSADGKCLVSVGLDDFHSIVFWDWKK------GEKIATTRGHKD-KIFVVKCN 825
VC+L FS G L VG D + W GE + + H D + +
Sbjct: 454 HVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVT 513
Query: 826 PHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLE-TMMCVSYGR------MEDLV 878
++ + G ++ W+ GG S G L+ T + R ++
Sbjct: 514 FFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAML 573
Query: 879 FSGAATGDIFIWKDILLLKTVKAH---------------------DGPVFAMYALDKG-- 915
F + +G I +I + V H GP A+ +L
Sbjct: 574 FVCSRSGHIL---EIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPA 630
Query: 916 -FVTGGKDGIVELWDDMFERCL--KTYAIKRSALSTSSKGLLLEDNPSIRAITLGH-GHI 971
G +DG + LW F L + S++ S GL + + A + GH G +
Sbjct: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRV-----LSATSSGHLGFL 685
Query: 972 LVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQH 1031
++ +L + P+ L G++ ATVS D+T+RIW+L+
Sbjct: 686 DTLSRVYHMLARSHTAPVLALAMEQRRGQL------------ATVSQDRTVRIWDLATLQ 733
Query: 1032 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFS 1091
++ + F P G + G+ + + E +V + ++ + +
Sbjct: 734 QLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTAT 793
Query: 1092 KD 1093
D
Sbjct: 794 PD 795
Score = 73.2 bits (178), Expect = 2e-12
Identities = 112/507 (22%), Positives = 186/507 (36%), Gaps = 56/507 (11%)
Query: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
L L V G+ G R L + DGA +++ A +V + TG Q F+L HTD + L +
Sbjct: 359 LRLKGVIGFGGHGTRQAL-WTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALAL 417
Query: 1423 NQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGV 1482
+ +++A++Q + +WD T L + R V ++FS +G LL VG
Sbjct: 418 DGS---SSLLASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLSFSDSGALLCGVGK 473
Query: 1483 DPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSD-----------TQFVSVGVKHMK 1531
D V W G GG E + + + D D T+ S G ++
Sbjct: 474 DHHGRTMVVAW--GTGQVGLGG--EVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVR 529
Query: 1532 FWTLAGSALLYKKGVIGSLGAAKMQTMLSVAF---------GANNLTFTGAINGDVYVWK 1582
W L G L + LG +AF + + F + +G +
Sbjct: 530 LWRLRGGVL---RSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEID 586
Query: 1583 DHFLI-----RLVAKAHTGPVFTMYTTLRDG-------LIVTGGKERPTKEGGAVKLWDQ 1630
++ RL+ G T G L V+ E G ++LW
Sbjct: 587 CQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPL 646
Query: 1631 EMKRCRAFQLETGQLVECVRSVCRGKG--KILVGTKDGEIIEVGEKNAASNILIDGHMEG 1688
+ G V SVC ++L T G + + + ++L H
Sbjct: 647 DFSSVLLEAEHEGP----VSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSH-TA 701
Query: 1689 EIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCA-AYSPDGEMVAIGM 1747
+ LA + + S D T RIWDLA + L + A CA + P G
Sbjct: 702 PVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGF 761
Query: 1748 KNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGT-NLN 1806
+G + + +V + + A+ + +PD R L S+ ++ Y ++
Sbjct: 762 SSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVL 821
Query: 1807 RIG---YCKDIPSFVIQMDFSADGKYI 1830
R+ C D P+ + S DG+ +
Sbjct: 822 RVAADMVCPDAPASPSALAVSRDGRLL 848
Score = 73.2 bits (178), Expect = 2e-12
Identities = 107/465 (23%), Positives = 182/465 (39%), Gaps = 56/465 (12%)
Query: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
L L V GY G + R N+ + D + +V++L +G+Q + H+ +I L +
Sbjct: 1108 LRLKAVVGYSG-NGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
Query: 1423 NQHPKYRNVVATSQIGTTP--SIHIWDA---MTKHTLSMLRCFHSKGVNYINFSATGKLL 1477
+ H A+ + TT I +WD + +H + HS V + FS +LL
Sbjct: 1167 S-HSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFP----HSTTVLALAFSPDDRLL 1221
Query: 1478 VSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAG 1537
V++G T+ +W V+S E + V F P + VG + FW L
Sbjct: 1222 VTLGDHDGRTLALWGTATYDLVSST-RLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQ 1280
Query: 1538 -----SALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAK 1592
S + ++ V ++GA + + S+ +GA L + G +G V VW
Sbjct: 1281 RGADISLQVRREPVPEAVGAGE---LTSLCYGAPPLLYCGTSSGQVCVW----------D 1327
Query: 1593 AHTGPVFTMYTTLRDG---LIVTGGKERPTKEGGAVKLW---DQEMKRCRAFQLET---- 1642
G F + G L+ +G + G ++LW RC+ +
Sbjct: 1328 TRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFME 1387
Query: 1643 ------GQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATH 1696
G +V G +VGT G + V S LI GH ++ +
Sbjct: 1388 HELVLDGAVVSASFDDSVDMG--VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFS 1444
Query: 1697 PSKDLFISASNDGTARIWDLADKKLLNKVS-LGHAARCAAYS------PDGEMVAIGMKN 1749
P + + S DG+ R+W LA +L+ + L + C A+S P+ + +A G +
Sbjct: 1445 PGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGD 1504
Query: 1750 GEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTV 1794
G I V+ + K A+ + S D + + G + V
Sbjct: 1505 GSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLV 1549
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 134 bits (338), Expect = 7e-31
Identities = 132/547 (24%), Positives = 236/547 (43%), Gaps = 76/547 (13%)
Query: 663 AVPFLKREK-APEDSLKLQFIHGYRGYDCRN--NLFYTQAGEVVYHIAAVAVVYNRQQHS 719
++PF+ + P D L L +H + GYDCR NL +Y IA +++ +
Sbjct: 118 SMPFVTLDSNIPLDLLTL--VHSF-GYDCRKRANLQLLDDSIAIY-IAGNQLIFLNLKTK 173
Query: 720 QRLYL--GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCA 777
+++YL + I + +HP K Y + G I +++ +L+ +L+ ++G
Sbjct: 174 EQIYLRSSSGEGIGVIGVHPHKTYFTVAEKGSFPDIIIYEYPSLRPYRVLRDGTEKGYAY 233
Query: 778 LDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
+DF+ G L SVG + +++ W+WK+ + I T+ ++F V NP ++L T G
Sbjct: 234 VDFNYSGNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGS 293
Query: 838 KHIKFWQQAGGGFT----SKRGTFGSVGKLETMMCVSYGRMED-LVFSGAATGDIFIWKD 892
HIKFW+ A FT +G+ G GK T Y + D V SG+ G++ +W+
Sbjct: 294 GHIKFWEMA---FTFTGLKLQGSLGRFGKTITTDIEGYMELPDGKVLSGSEWGNMLLWEG 350
Query: 893 ILLL------KTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSAL 946
L+ + H+GP+ + + +T G DG V +WD FE I + L
Sbjct: 351 GLIKVELCRGTSKSCHNGPINQIMLYEGEVITVGSDGYVRIWD--FETIDTADVIDETGL 408
Query: 947 STSSKGLLLEDNPSIRAITL------GHGHILVGTKNGEILEIDKS------GPMTLLVQ 994
L+ + ++ ++ G+ L NG I ++D S P L
Sbjct: 409 LEIEPINELQVDKNVNLFSMIKMNETGNNFWLAQDANGAIWKLDLSFSNITQDPECLF-- 466
Query: 995 GHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSP---- 1050
G + +A PL + AT + D ++RI++ A LA K K+GG + P
Sbjct: 467 SFHSGAIEAVAVSPLTYLMATTALDCSVRIYDF-ASKTPLAQMKFKQGGTALVWVPRMVN 525
Query: 1051 -DGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMI-SDIKFSKDTGKYLAVASHDNFVD 1108
G + VG DG ++ + + F RK+++ +DI+ +
Sbjct: 526 FTGAQIIVGFEDGVVRILELYDPKGLTIFAGRKKILDADIQLKQ---------------- 569
Query: 1109 IYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKR---HIIRPS 1165
+ K ++ +T + ++ G++L S + FFE R + +I P
Sbjct: 570 -----------VFKPHTACVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPG 618
Query: 1166 EIEKIEW 1172
+ ++ W
Sbjct: 619 PVCQLMW 625
Score = 122 bits (306), Expect = 3e-27
Identities = 115/490 (23%), Positives = 204/490 (41%), Gaps = 82/490 (16%)
Query: 21 GHQCRNNL-YYTAGKEVVYFVAGVGVVYNTREHSQKFFL--GHNDDIISLALHPDKTLVA 77
G+ CR + ++AG +++ + ++ +L + I + +HP KT
Sbjct: 140 GYDCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEGIGVIGVHPHKTYFT 199
Query: 78 TGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDW 137
+ G P I I++ +++ +L+D G A + F+ G LASVG + T+ IW+W
Sbjct: 200 VAEKGSFPDIIIYEYPSLRPYRVLRDGTEKGYAYVDFNYSGNLLASVGSNPDYTLTIWNW 259
Query: 138 RKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFW----TLCGNALTAKRGIFGK 193
++ + + S +F ++++P + ++ + G HIKFW T G L G FGK
Sbjct: 260 KEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGK 319
Query: 194 --TGDLQTILCLACAKEDITYSGALNGDIYVWKG----LNLVR-TIQGAHSAGIFSMYAC 246
T D++ + L K SG+ G++ +W+G + L R T + H+ I +
Sbjct: 320 TITTDIEGYMELPDGK---VLSGSEWGNMLLWEGGLIKVELCRGTSKSCHNGPINQIMLY 376
Query: 247 EEGFATGGRDGCIRLWD---------------TDFKPITKID----------LRETEQG- 280
E T G DG +R+WD + +PI ++ ++ E G
Sbjct: 377 EGEVITVGSDGYVRIWDFETIDTADVIDETGLLEIEPINELQVDKNVNLFSMIKMNETGN 436
Query: 281 --YKGLSIRSVCWKADRLLAG-TQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKK 337
+ WK D + TQD E L G + A+A+ P
Sbjct: 437 NFWLAQDANGAIWKLDLSFSNITQDPE--------------CLFSFHSGAIEAVAVSPLT 482
Query: 338 PLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSP-----DGSQLALGMKDGSFIV 392
L T + D SVR++ A +A+ ++ ++ + P G+Q+ +G +DG +
Sbjct: 483 YLMATTALDCSVRIYDFASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVVRI 542
Query: 393 LRVRDMTEVVHIKDRKEV-----------------IHEMKFSPDGSYLAVGSNDGPVDVY 435
L + D + RK++ + + + DG LA GS D V +
Sbjct: 543 LELYDPKGLTIFAGRKKILDADIQLKQVFKPHTACVTALAYERDGEILATGSKDQTVFFF 602
Query: 436 AVAQRYKKIG 445
V + YK IG
Sbjct: 603 EVERDYKPIG 612
Score = 114 bits (286), Expect = 7e-25
Identities = 145/613 (23%), Positives = 253/613 (41%), Gaps = 86/613 (14%)
Query: 1274 QESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQLKEVSVE 1333
+++ ++ + +T + +G Y + + E+ ++ + + +++ T QQ +VE
Sbjct: 38 EDNTFLEDDTDETFTKGEGSYLEEDSDEERLEGSLSSFQYG--DLQSTTVPQQTPAPAVE 95
Query: 1334 E-----RPPVSRA--------APQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRN-- 1378
E + +S + A P +NI ++ L L H FGY DCR
Sbjct: 96 EAEEEVKKKISESFFYDYMELASMPFVTLDSNIP-----LDLLTLVHSFGY---DCRKRA 147
Query: 1379 NLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIG 1438
NL L+D I+ I NL T Q YL + + HP ++ ++ G
Sbjct: 148 NLQLLDDSI-AIYIAGNQLIFLNLKTKEQ-IYLRSSSGEGIGVIGVHP-HKTYFTVAEKG 204
Query: 1439 TTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAK 1498
+ P I I++ + +LR KG Y++F+ +G LL SVG +P++T+T+W W+E
Sbjct: 205 SFPDIIIYEYPSLRPYRVLRDGTEKGYAYVDFNYSGNLLASVGSNPDYTLTIWNWKEEQP 264
Query: 1499 VASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSAL-LYKKGVIGSLGAAKMQT 1557
+ + +F V F PD + Q + G H+KFW +A + L +G +G G
Sbjct: 265 ILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGKTITTD 324
Query: 1558 MLSVAFGANNLTFTGAINGDVYVWKDHF----LIRLVAKA-HTGPVFTMYTTLRDGLIVT 1612
+ + +G+ G++ +W+ L R +K+ H GP+ + L +G ++T
Sbjct: 325 IEGYMELPDGKVLSGSEWGNMLLWEGGLIKVELCRGTSKSCHNGPINQI--MLYEGEVIT 382
Query: 1613 GGKERPTKEGGAVKLWDQEMKRCRAFQLETGQL-VECVRSVCRGK-----GKILVGTKDG 1666
G + G V++WD E ETG L +E + + K I +
Sbjct: 383 VGSD------GYVRIWDFETIDTADVIDETGLLEIEPINELQVDKNVNLFSMIKMNETGN 436
Query: 1667 EIIEVGEKNAA--------SNILID-----GHMEGEIWGLATHPSKDLFISASNDGTARI 1713
+ N A SNI D G I +A P L + + D + RI
Sbjct: 437 NFWLAQDANGAIWKLDLSFSNITQDPECLFSFHSGAIEAVAVSPLTYLMATTALDCSVRI 496
Query: 1714 WDLADKKLLNKVSLGHAARCAAYSP-----DGEMVAIGMKNGEFVILLVNSLK----VWG 1764
+D A K L ++ + P G + +G ++G IL + K G
Sbjct: 497 YDFASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVVRILELYDPKGLTIFAG 556
Query: 1765 KKRDRKSAIQ-------------DIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYC 1811
+K+ + IQ + D LA GS + TV F+++ + + IGY
Sbjct: 557 RKKILDADIQLKQVFKPHTACVTALAYERDGEILATGSKDQTVFFFEVER--DYKPIGYI 614
Query: 1812 KDIPSFVIQMDFS 1824
+ P V Q+ +S
Sbjct: 615 -NTPGPVCQLMWS 626
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 100 bits (250), Expect = 1e-20
Identities = 169/766 (22%), Positives = 289/766 (37%), Gaps = 158/766 (20%)
Query: 36 VVYFVAGVGVVYNTREHSQKFFLGHN-DDIISLALHPDKTLVATGQVGKEPYICIWDSYN 94
V Y V V++N R+H Q L + I +LA PD + TG+ G P + +WD
Sbjct: 64 VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
Query: 95 VQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIF 154
V+ L++ H +GVAC+AF + + SVG V +W W+K ++AS S R+
Sbjct: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVAS-NKVSSRVT 181
Query: 155 DISWDPYQPNRVVSCGVKHIKFWTLCG------NALTAKRGIFGKTGDLQT-----ILCL 203
+S+ + V+ G +HIKFW L NA G G G+L+ + C
Sbjct: 182 AVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
Query: 204 ACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWD 263
K D T+ +G + + L+ + + ++ G DG +RL
Sbjct: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHCISVSQDYIFCGCADGTVRL-- 298
Query: 264 TDFKPITKIDLRETEQGYK-GLSIRSVCWKADRLLAGT---------------------- 300
F P L + + G I SV +A RL +G
Sbjct: 299 --FNPSNLHFLSTLPRPHALGTDIASVT-EASRLFSGVANARYPDTIALTFDPTNQWLSC 355
Query: 301 --QDSEIFEVIVRERDKPMLILQG-HCEGELWALALHPK----------KPLAVTGSDDR 347
D I+ VR+ K + + +W++ ++P+ +T S D
Sbjct: 356 VYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDN 415
Query: 348 SVRLWSL---------------------------------------ADHALIARCNMEEA 368
++RLW+ D A + +
Sbjct: 416 TIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVG 475
Query: 369 VRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFS-PDG--SYLAV 425
+RSV SP+G LA G + G+ V ++ ++E++ ++ I +++S PD LA
Sbjct: 476 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 535
Query: 426 GSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSL-DSKYLQTNDGAGERLFYRMPSGK 484
S D + V + Y + S IT + ++ D + + GA + +++R
Sbjct: 536 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFR----- 590
Query: 485 PLTSKEEIKGIPWASW------TCVKGPEVSGIWPKYTEV--TDINSVDANYNSSVL--- 533
T+++ G+ + T + +V W KYT + D N N +S
Sbjct: 591 --TAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISSGKQKKL 647
Query: 534 ---VSGDDFGLVKLFKFPC-----------------LKRGAKFRKYVGHSAHVTNVRWSH 573
G+D L+K+ P G GHS VT +++S+
Sbjct: 648 FKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSN 707
Query: 574 DFQWVLSTGGADHSVFQWRFIPE---GVSNGMLETAPQEGGADSYS------------EE 618
D + ++S G D +F WR E + + E ++ G +
Sbjct: 708 DCKHLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQ 766
Query: 619 SDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAV 664
+ S LS P L SD ++E + + +E+LP L +K A+
Sbjct: 767 APSMLSPGPALSSDSDKEG----EDEGTEEELPALPVLAKSTKKAL 808
Score = 77.8 bits (190), Expect = 1e-13
Identities = 129/552 (23%), Positives = 209/552 (37%), Gaps = 92/552 (16%)
Query: 682 IHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHD-DDILSLTIHPVKD 740
+ G RG C ++G V Y V V++N ++H Q L I +L P
Sbjct: 49 VSGGRGLACD-----PRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 741 YVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVF 800
Y+ TG+ G A+ VWD ++ L+ +H+ GV + FS K +VSVG +
Sbjct: 104 YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
Query: 801 WDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSK------- 853
W WKK +A+ + ++ V + VT G +HIKFW TSK
Sbjct: 163 WAWKKNIVVASNK-VSSRVTAVSFS-EDCSYFVTAGNRHIKFW-YLDDSKTSKVNATVPL 219
Query: 854 RGTFGSVGKLE----TMMCVSYGRMEDLVFSGAATGDIFIWKDILLL-KTVKAHDGPVFA 908
G G +G+L T + G+ D F ++G + + D LL K V+
Sbjct: 220 LGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHC 279
Query: 909 MYALDKGFVTGGKDGIVELWDDMFERCLKT----YAIKRSALSTSS-----KGLLLEDNP 959
+ G DG V L++ L T +A+ S + G+ P
Sbjct: 280 ISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYP 339
Query: 960 SIRAITLGHGHILVGTKNG-------EILEIDKSGPMTLLVQGHMEGEVWGLAAHP---- 1008
A+T + + ++ + K G + + + VW + +P
Sbjct: 340 DTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSAL--YHSSCVWSVEVYPEVKD 397
Query: 1009 ----LLPICA--TVSDDKTLRIWEL-------SAQHRMLAVRKLKK-------------- 1041
LP + T S D T+R+W S HR + L K
Sbjct: 398 SNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDT 457
Query: 1042 -----------------GGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEM 1084
G R SP+G+ LA G G+ V ++ +M+
Sbjct: 458 ELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSE 517
Query: 1085 ISDIKFSK-DTG-KYLAVASHDNFVDIYNVLTSKRV-GICKGASSYITHIDW-DSRGKLL 1140
I +++SK DTG K LA AS D + + + + SS IT + + S G++
Sbjct: 518 ILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVR 577
Query: 1141 QVNSGAREQLFF 1152
++ GA + ++F
Sbjct: 578 MISCGADKSIYF 589
Score = 63.2 bits (152), Expect = 2e-09
Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 15/143 (10%)
Query: 1417 ILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKL 1476
I L + KY + T + G P++ +WD ++ L+ H GV + FS + K
Sbjct: 93 ITALAFSPDGKY---LVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKY 148
Query: 1477 LVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA 1536
+VSVG + + VW W++ VAS R+ V F D + FV+ G +H+KFW L
Sbjct: 149 IVSVGYQHDMIVNVWAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLD 206
Query: 1537 GS---------ALLYKKGVIGSL 1550
S LL + G++G L
Sbjct: 207 DSKTSKVNATVPLLGRSGLLGEL 229
Score = 48.5 bits (114), Expect = 6e-05
Identities = 74/277 (26%), Positives = 111/277 (40%), Gaps = 49/277 (17%)
Query: 1715 DLADKKLLN-KVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAI 1773
D AD LL+ +V + R SP+G+ +A G + G + + SL K S I
Sbjct: 463 DKADASLLDPRVGI----RSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEI 518
Query: 1774 QDIRIS-PDN--RFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSA-DGKY 1829
+ S PD + LA S + + D + +L + + S + + F+A DG+
Sbjct: 519 LCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQT--LDEHSSSITAVKFAASDGQV 576
Query: 1830 IQVSTGA----YKRQVHEVPLGKQVTEAV-VIEKITW------ASWTSVLGDEVIGIWPR 1878
+S GA Y R + G Q T V+ K T SW IG R
Sbjct: 577 RMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYT----AIGCQDR 632
Query: 1879 NADKADVNCAC-------------------VTHAGLNIVTGDDFGLVKLFDFPCTEKFAK 1919
N +++ +G+ I T + +FDF E A
Sbjct: 633 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVAT 692
Query: 1920 HKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1956
FGHS VT ++FS D K+++S GD C +FVWR
Sbjct: 693 ---MFGHSEIVTGMKFSNDCKHLISVSGDSC-IFVWR 725
Score = 32.7 bits (73), Expect = 3.6
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 15/167 (8%)
Query: 712 VYNRQQHSQRLYL-GHDDDILSLTIH-PVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKG 769
V+ Q S+ L + HD +IL L P RD IHV D L
Sbjct: 499 VHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD 558
Query: 770 QHQRGVCALDFSA-DGKC-LVSVGLDDFHSIVF-WDWKKGEKIATTRGH----KDKIFVV 822
+H + A+ F+A DG+ ++S G D SI F K G+ + TR H K ++ +
Sbjct: 559 EHSSSITAVKFAASDGQVRMISCGAD--KSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDM 616
Query: 823 KCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSKRGTFGSVGKLET 865
P + ++I+ + + G F +G G++ K++T
Sbjct: 617 DVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQT 663
Score = 31.6 bits (70), Expect = 8.0
Identities = 30/119 (25%), Positives = 50/119 (42%), Gaps = 6/119 (5%)
Query: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQF 1522
K + + FS GK LV+ + VW E ++VA H + V F P S
Sbjct: 91 KTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSP-SAKYI 149
Query: 1523 VSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW 1581
VSVG +H + + +KK ++ + + + +V+F + F A N + W
Sbjct: 150 VSVGYQH----DMIVNVWAWKKNIVVASNKVSSR-VTAVSFSEDCSYFVTAGNRHIKFW 203
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 100 bits (249), Expect = 1e-20
Identities = 171/772 (22%), Positives = 291/772 (37%), Gaps = 164/772 (21%)
Query: 36 VVYFVAGVGVVYNTREHSQKFFLGHN-DDIISLALHPDKTLVATGQVGKEPYICIWDSYN 94
V Y V V++N R+H Q L + I +LA PD + TG+ G P + +WD
Sbjct: 64 VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
Query: 95 VQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIF 154
V+ L++ H +GVAC+AF + + SVG V +W W+K ++AS S R+
Sbjct: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVAS-NKVSSRVT 181
Query: 155 DISWDPYQPNRVVSCGVKHIKFWTLCG------NALTAKRGIFGKTGDLQT-----ILCL 203
+S+ + V+ G +HIKFW L NA G G G+L+ + C
Sbjct: 182 AVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
Query: 204 ACAKEDITYSGALNGDIYVWKGLNL------VRTIQGAHSAGIFSMYACEEGFATGGRDG 257
K D T+ +G + + L +R I + + ++ G DG
Sbjct: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG 300
Query: 258 CIRLWDTDFKPITKIDLRETEQGYK-GLSIRSVCWKADRLLAGT---------------- 300
+RL F P L + + G I SV +A RL +G
Sbjct: 301 TVRL----FNPSNLHFLSTLPRPHALGTDIASVT-EASRLFSGVANARYPDTIALTFDPT 355
Query: 301 --------QDSEIFEVIVRERDKPMLILQG-HCEGELWALALHPK----------KPLAV 341
D I+ VR+ K + + +W++ ++P+ +
Sbjct: 356 NQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFI 415
Query: 342 TGSDDRSVRLWSL---------------------------------------ADHALIAR 362
T S D ++RLW+ D A +
Sbjct: 416 TCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASL 475
Query: 363 CNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFS-PDG- 420
+ +RSV SP+G LA G + G+ V ++ ++E++ ++ I +++S PD
Sbjct: 476 LDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTG 535
Query: 421 -SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSL-DSKYLQTNDGAGERLFY 478
LA S D + V + Y + S IT + ++ D + + GA + +++
Sbjct: 536 LKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYF 595
Query: 479 RMPSGKPLTSKEEIKGIPWASW------TCVKGPEVSGIWPKYTEV--TDINSVDANYNS 530
R T+++ G+ + T + +V W KYT + D N N +S
Sbjct: 596 R-------TAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISS 647
Query: 531 SVL------VSGDDFGLVKLFKFPC-----------------LKRGAKFRKYVGHSAHVT 567
G+D L+K+ P G GHS VT
Sbjct: 648 GKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVT 707
Query: 568 NVRWSHDFQWVLSTGGADHSVFQWRFIPE---GVSNGMLETAPQEGGADSYS-------- 616
+++S+D + ++S G D +F WR E + + E ++ G
Sbjct: 708 GMKFSNDCKHLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRAS 766
Query: 617 ----EESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAV 664
++ S LS P L SD ++E + + +E+LP L +K A+
Sbjct: 767 GPNRHQAPSMLSPGPALSSDSDKEG----EDEGTEEELPALPVLAKSTKKAL 814
Score = 76.3 bits (186), Expect = 3e-13
Identities = 128/558 (22%), Positives = 214/558 (38%), Gaps = 98/558 (17%)
Query: 682 IHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHD-DDILSLTIHPVKD 740
+ G RG C ++G V Y V V++N ++H Q L I +L P
Sbjct: 49 VSGGRGLACD-----PRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 741 YVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVF 800
Y+ TG+ G A+ VWD ++ L+ +H+ GV + FS K +VSVG +
Sbjct: 104 YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
Query: 801 WDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSK------- 853
W WKK +A+ + ++ V + VT G +HIKFW TSK
Sbjct: 163 WAWKKNIVVASNK-VSSRVTAVSFS-EDCSYFVTAGNRHIKFW-YLDDSKTSKVNATVPL 219
Query: 854 RGTFGSVGKLE----TMMCVSYGRMEDLVFSGAATGDIFIWKDILL------LKTVKAHD 903
G G +G+L T + G+ D F ++G + + D L L+ + +
Sbjct: 220 LGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFT 279
Query: 904 GPVFAMYALDKGFV-TGGKDGIVELWDDMFERCLKT----YAIKRSALSTSS-----KGL 953
V ++ + ++ G DG V L++ L T +A+ S + G+
Sbjct: 280 TTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGV 339
Query: 954 LLEDNPSIRAITLGHGHILVGTKNG-------EILEIDKSGPMTLLVQGHMEGEVWGLAA 1006
P A+T + + ++ + K G + + + VW +
Sbjct: 340 ANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSAL--YHSSCVWSVEV 397
Query: 1007 HP--------LLPICA--TVSDDKTLRIWEL-------SAQHRMLAVRKLKK-------- 1041
+P LP + T S D T+R+W S HR + L K
Sbjct: 398 YPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNT 457
Query: 1042 -----------------------GGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSF 1078
G R SP+G+ LA G G+ V ++ +M+
Sbjct: 458 QALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKV 517
Query: 1079 HHRKEMISDIKFSK-DTG-KYLAVASHDNFVDIYNVLTSKRV-GICKGASSYITHIDW-D 1134
I +++SK DTG K LA AS D + + + + SS IT + +
Sbjct: 518 EAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAA 577
Query: 1135 SRGKLLQVNSGAREQLFF 1152
S G++ ++ GA + ++F
Sbjct: 578 SDGQVRMISCGADKSIYF 595
Score = 63.2 bits (152), Expect = 2e-09
Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 15/143 (10%)
Query: 1417 ILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKL 1476
I L + KY + T + G P++ +WD ++ L+ H GV + FS + K
Sbjct: 93 ITALAFSPDGKY---LVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKY 148
Query: 1477 LVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA 1536
+VSVG + + VW W++ VAS R+ V F D + FV+ G +H+KFW L
Sbjct: 149 IVSVGYQHDMIVNVWAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLD 206
Query: 1537 GS---------ALLYKKGVIGSL 1550
S LL + G++G L
Sbjct: 207 DSKTSKVNATVPLLGRSGLLGEL 229
Score = 48.5 bits (114), Expect = 6e-05
Identities = 74/277 (26%), Positives = 111/277 (40%), Gaps = 49/277 (17%)
Query: 1715 DLADKKLLN-KVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAI 1773
D AD LL+ +V + R SP+G+ +A G + G + + SL K S I
Sbjct: 469 DKADASLLDPRVGI----RSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEI 524
Query: 1774 QDIRIS-PDN--RFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSA-DGKY 1829
+ S PD + LA S + + D + +L + + S + + F+A DG+
Sbjct: 525 LCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQT--LDEHSSSITAVKFAASDGQV 582
Query: 1830 IQVSTGA----YKRQVHEVPLGKQVTEAV-VIEKITW------ASWTSVLGDEVIGIWPR 1878
+S GA Y R + G Q T V+ K T SW IG R
Sbjct: 583 RMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYT----AIGCQDR 638
Query: 1879 NADKADVNCAC-------------------VTHAGLNIVTGDDFGLVKLFDFPCTEKFAK 1919
N +++ +G+ I T + +FDF E A
Sbjct: 639 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVAT 698
Query: 1920 HKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1956
FGHS VT ++FS D K+++S GD C +FVWR
Sbjct: 699 ---MFGHSEIVTGMKFSNDCKHLISVSGDSC-IFVWR 731
Score = 32.7 bits (73), Expect = 3.6
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 15/167 (8%)
Query: 712 VYNRQQHSQRLYL-GHDDDILSLTIH-PVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKG 769
V+ Q S+ L + HD +IL L P RD IHV D L
Sbjct: 505 VHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD 564
Query: 770 QHQRGVCALDFSA-DGKC-LVSVGLDDFHSIVF-WDWKKGEKIATTRGH----KDKIFVV 822
+H + A+ F+A DG+ ++S G D SI F K G+ + TR H K ++ +
Sbjct: 565 EHSSSITAVKFAASDGQVRMISCGAD--KSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDM 622
Query: 823 KCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSKRGTFGSVGKLET 865
P + ++I+ + + G F +G G++ K++T
Sbjct: 623 DVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQT 669
Score = 31.6 bits (70), Expect = 8.0
Identities = 30/119 (25%), Positives = 50/119 (42%), Gaps = 6/119 (5%)
Query: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQF 1522
K + + FS GK LV+ + VW E ++VA H + V F P S
Sbjct: 91 KTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSP-SAKYI 149
Query: 1523 VSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW 1581
VSVG +H + + +KK ++ + + + +V+F + F A N + W
Sbjct: 150 VSVGYQH----DMIVNVWAWKKNIVVASNKVSSR-VTAVSFSEDCSYFVTAGNRHIKFW 203
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 96.7 bits (239), Expect = 2e-19
Identities = 100/385 (25%), Positives = 169/385 (43%), Gaps = 33/385 (8%)
Query: 59 GHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDG 118
GH++ +IS+A P +A+G + + WD + +T H H V +++ DG
Sbjct: 112 GHSEAVISVAFSPTGKYLASGS--GDTTVRFWD-LSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 119 QRLASVGLDAKN-TVCIWDWRKGKLLA-SATGHSDRIFDISWDPYQPN---RVVSCGVKH 173
++LAS KN + +WD GK + + GHS I +SW+P N R V+ K
Sbjct: 169 RKLAS---GCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 174 --IKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLN--LV 229
++ W TA R TG Q++ CL + + YS + + I VW+ + L
Sbjct: 226 GSVRIWDT-----TAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 230 RTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSV 289
RT+QG H + +M A +A R G + P DL+ + Q K ++
Sbjct: 281 RTLQG-HGHWVNTM-ALSTDYAL--RTGAFEPAEASVNPQ---DLQGSLQELKERALSRY 333
Query: 290 CWKA----DRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSD 345
+RL++G+ D +F E KP+ + GH + + + P + + S
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-QALINQVLFSPDSRIVASASF 392
Query: 346 DRSVRLWSLADHALIARCNME-EAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHI 404
D+S++LW +A AV +A+S D L G D + V V+ + +
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 405 KDRKEVIHEMKFSPDGSYLAVGSND 429
+ ++ + +SPDG +A G D
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKD 477
Score = 67.0 bits (162), Expect = 2e-10
Identities = 100/438 (22%), Positives = 168/438 (38%), Gaps = 71/438 (16%)
Query: 392 VLRVRDMTEVVH-IKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKS 450
+ RVR +T ++ E + + FSP G YLA GS D V + ++ C
Sbjct: 97 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHF-TCKGH 155
Query: 451 LSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPL--TSKEEIKGIPWASWTCVKGPEV 508
++ I WS D + L + G+ L + +GK + T K I SW
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSW-------- 207
Query: 509 SGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTN 568
+ AN + S G V+++ G R GH+ VT
Sbjct: 208 -------------EPLHANPECRYVASSSKDGSVRIWD---TTAGRCERILTGHTQSVTC 251
Query: 569 VRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGMLETAPQEGGADSYSEESDSDLSDVPE 628
+RW D +L + D ++ WR +G+L Q G + +D +
Sbjct: 252 LRWGGD--GLLYSASQDRTIKVWR-----AHDGVLCRTLQGHGHWVNTMALSTDYA---- 300
Query: 629 LDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGY 688
L + + A+ + + Q + L +LK+++ + + V R + PE + + G +
Sbjct: 301 LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV----RGQGPE-----RLVSGSDDF 351
Query: 689 DCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVG 748
LF E + + GH I + P VA+
Sbjct: 352 ----TLFLWSPAEDKKPLTRMT--------------GHQALINQVLFSPDSRIVASASF- 392
Query: 749 RDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEK 808
D +I +WD +T K L+ L+G H V + +SAD + LVS D ++ WD K +
Sbjct: 393 -DKSIKLWDGRTGKYLASLRG-HVAAVYQIAWSADSRLLVSGSSDS--TLKVWDVKAQKL 448
Query: 809 IATTRGHKDKIFVVKCNP 826
GH D+++ V +P
Sbjct: 449 AMDLPGHADEVYAVDWSP 466
Score = 59.3 bits (142), Expect = 4e-08
Identities = 89/379 (23%), Positives = 156/379 (41%), Gaps = 55/379 (14%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADG 784
GH + ++S+ P Y+A+G D + WD T KG H+ V ++ +S DG
Sbjct: 112 GHSEAVISVAFSPTGKYLASG--SGDTTVRFWDLSTETPHFTCKG-HRHWVLSISWSPDG 168
Query: 785 KCLVSVGLDDFHSIVFWDWKKGEKIA-TTRGHKDKIFVVKCNPHHVD---KLVTVGIK-- 838
+ L S G + I+ WD G+++ T GH I + P H + + V K
Sbjct: 169 RKLAS-GCKN-GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 839 HIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWK--DILLL 896
++ W G R G +++ C+ +G + L++S + I +W+ D +L
Sbjct: 227 SVRIWDTTAG-----RCERILTGHTQSVTCLRWGG-DGLLYSASQDRTIKVWRAHDGVLC 280
Query: 897 KTVKAHDGPVFAM-----YALDKGF-----VTGGKDGIVELWDDMFERCLKTYAIKR--- 943
+T++ H V M YAL G + + ++ ER L Y + R
Sbjct: 281 RTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340
Query: 944 -SALSTSSKGLLL------EDNPSIRAITLGHGHIL---VGTKNGEIL---EIDKS---- 986
L + S L ED + +T GH ++ + + + I+ DKS
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMT-GHQALINQVLFSPDSRIVASASFDKSIKLW 399
Query: 987 ----GPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKG 1042
G ++GH+ V+ +A + + S D TL++W++ AQ + +
Sbjct: 400 DGRTGKYLASLRGHV-AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458
Query: 1043 GRCCAFSPDGKALAVGLND 1061
+SPDG+ +A G D
Sbjct: 459 VYAVDWSPDGQRVASGGKD 477
Score = 55.8 bits (133), Expect = 4e-07
Identities = 83/375 (22%), Positives = 138/375 (36%), Gaps = 67/375 (17%)
Query: 144 ASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCL 203
+S GHS+ + +++ P G ++FW L+ + F G +L +
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD-----LSTETPHFTCKGHRHWVLSI 162
Query: 204 ACAKEDITY-SGALNGDIYVW---KGLNLVRTIQGAHSAGIFS-----MYACEE--GFAT 252
+ + + SG NG I +W G + RT+ G HS I ++A E A+
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAG-HSKWITGLSWEPLHANPECRYVAS 221
Query: 253 GGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRE 312
+DG +R+WDT +I T+ S+ + W D LL +V
Sbjct: 222 SSKDGSVRIWDTTAGRCERILTGHTQ------SVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Query: 313 RDKPMLILQGH-------------------------------CEGEL----------WAL 331
LQGH +G L + L
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
Query: 332 ALHPKKPLAVTGSDDRSVRLWSLA-DHALIARCNMEEA-VRSVAFSPDGSQLALGMKDGS 389
V+GSDD ++ LWS A D + R +A + V FSPD +A D S
Sbjct: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 395
Query: 390 FIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSK 449
+ R + ++ ++++ +S D L GS+D + V+ V + K +
Sbjct: 396 IKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV-KAQKLAMDLPG 454
Query: 450 SLSFITHIDWSLDSK 464
+ +DWS D +
Sbjct: 455 HADEVYAVDWSPDGQ 469
Score = 47.4 bits (111), Expect = 1e-04
Identities = 89/420 (21%), Positives = 152/420 (36%), Gaps = 79/420 (18%)
Query: 1471 SATGKLLVSVGVDPEHTITV-WRWQEGAKV-------ASRGGHLERIFVVEFRPDSDTQF 1522
S+ GK L S V+ E + + ++ Q +V +S GH E + V F P
Sbjct: 71 SSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLA 130
Query: 1523 VSVGVKHMKFWTLAGSALLYK-KGVIGSLGAAKMQTMLSVAFGANNLTF-TGAINGDVYV 1580
G ++FW L+ + KG +LS+++ + +G NG + +
Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKG--------HRHWVLSISWSPDGRKLASGCKNGQILL 182
Query: 1581 WKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERP-------TKEGGAVKLWDQEMK 1633
W G ++ GL P + + G+V++WD
Sbjct: 183 WDPS------TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 236
Query: 1634 RCRAFQLETGQLVECVR----------------SVCRGKGKILVGTKDGE---------- 1667
RC Q V C+R V R +L T G
Sbjct: 237 RCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALS 296
Query: 1668 ---IIEVGEKNAASNILIDGHMEGEI----------WGLATHPSKDLFISASNDGTARIW 1714
+ G A + ++G + + L + +S S+D T +W
Sbjct: 297 TDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLW 356
Query: 1715 DLA-DKKLLNKVSLGHAARC--AAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKS 1771
A DKK L +++ GH A +SPD +VA + + + K R +
Sbjct: 357 SPAEDKKPLTRMT-GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415
Query: 1772 AIQDIRISPDNRFLAVGSSEHTVDFYDL-TQGTNLNRIGYCKDIPSFVIQMDFSADGKYI 1830
A+ I S D+R L GSS+ T+ +D+ Q ++ G+ + V +D+S DG+ +
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE----VYAVDWSPDGQRV 471
Score = 45.8 bits (107), Expect = 4e-04
Identities = 37/155 (23%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 990 TLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFS 1049
T ++GH E + +A P A+ S D T+R W+LS + + + ++S
Sbjct: 107 TSSLEGHSEAVI-SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 1050 PDGKALAVGLNDGSFLVVNADTVEDM-VSFHHRKEMISDIKF----SKDTGKYLAVASHD 1104
PDG+ LA G +G L+ + T + + + + I+ + + + +Y+A +S D
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 1105 NFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKL 1139
V I++ + I G + +T + W G L
Sbjct: 226 GSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLL 260
Score = 41.2 bits (95), Expect = 0.010
Identities = 81/421 (19%), Positives = 151/421 (35%), Gaps = 66/421 (15%)
Query: 762 KCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFV 821
+C S L+G H V ++ FS GK L S D ++ FWD T +GH+ +
Sbjct: 105 RCTSSLEG-HSEAVISVAFSPTGKYLASGSGDT--TVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 822 VKCNPHHVDKLVTVGIKH--IKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVF 879
+ +P + + G K+ I W + G + T K T +
Sbjct: 162 ISWSPD--GRKLASGCKNGQILLWDPSTGKQVGR--TLAGHSKWITGLS----------- 206
Query: 880 SGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTY 939
W+ + H P A + KDG V +WD RC
Sbjct: 207 ----------WEPL--------HANPECRYVA------SSSKDGSVRIWDTTAGRC---- 238
Query: 940 AIKRSALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKS--GPMTLLVQGHM 997
+ +L S+ + G +L +++ ++ G + +QGH
Sbjct: 239 -----------ERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Query: 998 EG-EVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALA 1056
L+ L A + ++ +L + L R L + P+ L
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE--RLV 345
Query: 1057 VGLNDGS-FLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS 1115
G +D + FL A+ + + + +I+ + FS D+ + +A AS D + +++ T
Sbjct: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS-RIVASASFDKSIKLWDGRTG 404
Query: 1116 KRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTW 1175
K + +G + + I W + +LL S ++ K + P +++ W
Sbjct: 405 KYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDW 464
Query: 1176 T 1176
+
Sbjct: 465 S 465
Score = 41.2 bits (95), Expect = 0.010
Identities = 48/193 (24%), Positives = 74/193 (38%), Gaps = 32/193 (16%)
Query: 1077 SFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSR 1136
S E + + FS TGKYLA S D V +++ T CKG ++ I W
Sbjct: 109 SLEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Query: 1137 GKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSD-ITD 1195
G+ L + L ++ GK+ +G T G HS IT
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQ-------------------VGRTLAG----HSKWITG 204
Query: 1196 VNAASL--TKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVL 1253
++ L +C +A+ G V+++ G+ R GH+ VT +RW L
Sbjct: 205 LSWEPLHANPECRYVASSSKDGSVRIWD-TTAGRCERI--LTGHTQSVTCLRW--GGDGL 259
Query: 1254 LTVGGADTALMIW 1266
L D + +W
Sbjct: 260 LYSASQDRTIKVW 272
Score = 40.4 bits (93), Expect = 0.017
Identities = 85/372 (22%), Positives = 135/372 (36%), Gaps = 39/372 (10%)
Query: 1172 WDTWTCVLGPTCEGI--WPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHA 1229
WD T TC+G W V + S + D LA+G G + L+ P G+
Sbjct: 141 WDLSTETPHFTCKGHRHW--------VLSISWSPDGRKLASGCKNGQILLWD-PSTGKQV 191
Query: 1230 RFKKYVGHSAHVTNVRW--LHNDSVLLTVGGA--DTALMIWTREFVGTQESKLVDSEESD 1285
+ GHS +T + W LH + V + D ++ IW G E L +S
Sbjct: 192 G-RTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTT-AGRCERILTGHTQSV 249
Query: 1286 TDVEEDG-GYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQLKEVSVEERPPVSRAAPQ 1344
T + G G ++++ I V R ++G +S + P
Sbjct: 250 TCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPA 309
Query: 1345 PEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLST 1404
+ ++ + ++E AL RG + +D ++ A T
Sbjct: 310 EASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMT 369
Query: 1405 GSQSFYLEHTDDILCLTVNQ---HPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFH 1461
G Q+ +NQ P R V + S SI +WD T L+ LR H
Sbjct: 370 GHQAL------------INQVLFSPDSRIVASAS---FDKSIKLWDGRTGKYLASLRG-H 413
Query: 1462 SKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQ 1521
V I +SA +LLVS D T+ VW + GH + ++ V++ PD
Sbjct: 414 VAAVYQIAWSADSRLLVSGSSDS--TLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRV 471
Query: 1522 FVSVGVKHMKFW 1533
K ++ W
Sbjct: 472 ASGGKDKCLRIW 483
Score = 39.3 bits (90), Expect = 0.038
Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 53/153 (34%)
Query: 114 FDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKH 173
F D + +AS D ++ +WD R GK LAS GH ++ I+W
Sbjct: 380 FSPDSRIVASASFD--KSIKLWDGRTGKYLASLRGHVAAVYQIAWS-------------- 423
Query: 174 IKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW--KGLNLVRT 231
A + SG+ + + VW K L
Sbjct: 424 --------------------------------ADSRLLVSGSSDSTLKVWDVKAQKLAMD 451
Query: 232 IQGAHSAGIFSMYACEEG--FATGGRDGCIRLW 262
+ G H+ ++++ +G A+GG+D C+R+W
Sbjct: 452 LPG-HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 39.3 bits (90), Expect = 0.038
Identities = 24/68 (35%), Positives = 38/68 (55%), Gaps = 4/68 (5%)
Query: 1684 GHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAA--YSPDGE 1741
GH+ ++ +A L +S S+D T ++WD+ +KL + GHA A +SPDG+
Sbjct: 412 GHVAA-VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP-GHADEVYAVDWSPDGQ 469
Query: 1742 MVAIGMKN 1749
VA G K+
Sbjct: 470 RVASGGKD 477
Score = 38.5 bits (88), Expect = 0.065
Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 1772 AIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQ 1831
A+ + SP ++LA GS + TV F+DL+ T CK +V+ + +S DG+ +
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFT---CKGHRHWVLSISWSPDGR--K 170
Query: 1832 VSTGAYKRQV--HEVPLGKQV--TEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNC 1887
+++G Q+ + GKQV T A + IT SW + A+ C
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL--------------HANPEC 216
Query: 1888 ACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGG 1947
V + + G V+++D T + GH+ VT +R+ D ++ +
Sbjct: 217 RYVASSSKD-------GSVRIWD---TTAGRCERILTGHTQSVTCLRWGGDG--LLYSAS 264
Query: 1948 DDCSVFVWR 1956
D ++ VWR
Sbjct: 265 QDRTIKVWR 273
Score = 32.0 bits (71), Expect = 6.1
Identities = 18/80 (22%), Positives = 34/80 (42%), Gaps = 2/80 (2%)
Query: 1461 HSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDT 1520
H +N + FS +++ S D +I +W + G +AS GH+ ++ + + DS
Sbjct: 371 HQALINQVLFSPDSRIVASASFDK--SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRL 428
Query: 1521 QFVSVGVKHMKFWTLAGSAL 1540
+K W + L
Sbjct: 429 LVSGSSDSTLKVWDVKAQKL 448
>gi|145279222 WD repeat domain 66 [Homo sapiens]
Length = 1149
Score = 77.4 bits (189), Expect = 1e-13
Identities = 93/490 (18%), Positives = 179/490 (36%), Gaps = 57/490 (11%)
Query: 3 DRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHND 62
D++ P L + W +G+ + + ++Y A ++YN ++Q GH +
Sbjct: 241 DKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHAN 300
Query: 63 DIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKD--VHTHGVACLAFDSDGQR 120
I L + D+ +AT G + + IWDS+ V + D +G+ +A D +
Sbjct: 301 IISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKY 360
Query: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFD----ISWDPYQPNRVVSCGVKHIKF 176
LA++ VCIW W + T + ++++P +VS +
Sbjct: 361 LATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIY 420
Query: 177 W-------TLCGNALTAKRGIFGK-TGDL-QTILCLACAKEDITYSGALNGDIYVWK--- 224
+ TL +A F K G Q+I L + S + G + VW
Sbjct: 421 YAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQ---ILSATMEGKLVVWDIHR 477
Query: 225 ---------GLNLVRTIQGAH--SAGIFSMYACEEGFATGGRDGCIRLWD---------- 263
G ++ + H GI + + TG G I+ +D
Sbjct: 478 PPSSASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYS 537
Query: 264 ---------TDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERD 314
F E +++ + + GT D+ ++ +
Sbjct: 538 HLKLGAIRTLSFSKTPATPPTEKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTK 597
Query: 315 KPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEE--AVRSV 372
L ++ + + A++ HP +PL GS +++W+ + + E+ V+S+
Sbjct: 598 LEKLFVEP--KDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSL 655
Query: 373 AFSPDGSQLALGMKDGSFIVLRVRDM--TEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDG 430
++P+G+ L G +G+ +L + K + + + FS D Y+A
Sbjct: 656 TYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSF 715
Query: 431 PVDVYAVAQR 440
V VY + R
Sbjct: 716 TVAVYMLVVR 725
Score = 62.4 bits (150), Expect = 4e-09
Identities = 81/453 (17%), Positives = 174/453 (38%), Gaps = 50/453 (11%)
Query: 702 VVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTL 761
++Y A A++YN +++Q GH + I L + + ++AT G D + +WD+ T
Sbjct: 274 LLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTG 333
Query: 762 KCLSLL--KGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKG-EKIATTRGHKDK 818
+ + G+ A+ + D K L ++ + + W W E A T +
Sbjct: 334 IPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTE 393
Query: 819 IFV---VKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVS--YGR 873
V V NP + +LV+ ++ + +R T L T + G+
Sbjct: 394 YGVQNYVTFNPTNNKELVSNSKTRAIYY-----AWYEERDTLAHSAPLLTEKTFNKLVGK 448
Query: 874 MEDLVF--------SGAATGDIFIW---------------KDILLLKTVKAHDGPVFAMY 910
+F S G + +W I K V + +
Sbjct: 449 FSQSIFHLNLTQILSATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLT 508
Query: 911 ALDKGFVTGGKDGIVELWDDMFE----------RCLKTYAIKRSALSTSSKGLLLEDNPS 960
+D VTG G ++ +D ++T + ++ + ++ + +
Sbjct: 509 TIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPTEKSNYPPDCT 568
Query: 961 IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK 1020
++ + ++GT + + + G + + + ++ HP P+ A S
Sbjct: 569 LKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICG 628
Query: 1021 TLRIWEL-SAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVED--MVS 1077
+++W + Q+ V + G + ++P+G L G +G+ +++A ++E+
Sbjct: 629 MIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEP 688
Query: 1078 FHHRKEMISDIKFSKDTGKYLAVASHDNFVDIY 1110
F + + ++ I FS D+ +Y+A A V +Y
Sbjct: 689 FKYSRTSVTHISFSHDS-QYMATADRSFTVAVY 720
Score = 59.3 bits (142), Expect = 4e-08
Identities = 98/468 (20%), Positives = 178/468 (38%), Gaps = 76/468 (16%)
Query: 1389 IIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDA 1448
+++ A I+ N+ +Q H + I CL V++ ++ +AT+ G + IWD+
Sbjct: 274 LLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRW---IATADKGPDCLVIIWDS 330
Query: 1449 MTK---HTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGH 1505
T HT+ C G+ + + K L ++ + +W+W + +
Sbjct: 331 FTGIPVHTI-FDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLE 389
Query: 1506 LERIFVVE----FRPDSDTQFVSVGVKHMKFW-------TLAGSALLYKKGVIGSLGAAK 1554
L + V+ F P ++ + VS ++ TLA SA L + L
Sbjct: 390 LPTEYGVQNYVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKF 449
Query: 1555 MQTMLSVAFGANNLT--FTGAINGDVYVWKDH--------FL-------IRLVAKAHTGP 1597
Q++ + NLT + + G + VW H FL +LV G
Sbjct: 450 SQSIFHL-----NLTQILSATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEG- 503
Query: 1598 VFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQ-LETGQLVECVRSV---- 1652
T+ TT+ D IVTG + G +K +D + + L+ G + S
Sbjct: 504 -ITVLTTI-DSYIVTGDIK------GNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPAT 555
Query: 1653 -----------CRGKGKI------LVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLAT 1695
C KG + ++GT D + + L + I ++
Sbjct: 556 PPTEKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDA-ICAISC 614
Query: 1696 HPSKDLFISASNDGTARIWDLADKKLL--NKVSLGHAARCAAYSPDGEMVAIGMKNGEFV 1753
HP + L S G ++W+ +K+ L G + Y+P+G ++ G G
Sbjct: 615 HPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVY 674
Query: 1754 ILLVNSLKVWGKK--RDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDL 1799
IL SL+ + + ++++ I S D++++A TV Y L
Sbjct: 675 ILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYML 722
Score = 33.5 bits (75), Expect = 2.1
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSK-SLSFITHIDWSLDSKYLQTN 469
+ + ++P+G+ L G +G V + + E K S + +THI +S DS+Y+ T
Sbjct: 652 VQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATA 711
Query: 470 D 470
D
Sbjct: 712 D 712
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 74.7 bits (182), Expect = 8e-13
Identities = 133/639 (20%), Positives = 247/639 (38%), Gaps = 69/639 (10%)
Query: 1 MADRTAPRCQ---LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFF 57
M ++ +P Q L L+ V G+ GH + + ++Y + ++ Q F
Sbjct: 1 MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFL 60
Query: 58 LGHNDDIISLALHPDKTLVATGQV---GKEPYICIWDSYNVQTVSLLKDVHTHGVACLAF 114
GH +++ LA+ +A+GQV G + I +WD N + ++ L +H + LAF
Sbjct: 61 QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAF 119
Query: 115 DSDGQRLASVGLDAKNTVCIWDWRKGKLLASATG---HSDRIFDISWDPYQPNRVVSCGV 171
+ L S+G +V +W K + + + ++ + + ++ G
Sbjct: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGN 179
Query: 172 KHIKFWTLCGNALTAKRGIFG---KTGDLQTILCLACAKED--ITYSGALNGDIYVW--- 223
I+ W L R I+ +TG L+ I+ +D Y G GDI
Sbjct: 180 GTIRVWELD----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPR 235
Query: 224 -KGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLW--DTDFKPITKIDLRETEQG 280
K L V + S G+ ++ + G G + ++ +KPI KI L + G
Sbjct: 236 TKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQL---QGG 292
Query: 281 YKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLA 340
+++R + + L GT++S I+ V + K LI H + + L
Sbjct: 293 ITSITLRG---EGHQFLVGTEESHIYRVSFTD-FKETLIATCHFDAVEDIVFPFGTAELF 348
Query: 341 VTGSDDRSVRLWSLADHALIARCNMEE-AVRSVAFSPDGSQLALGMKDGSFIVLRVRDMT 399
T + + +R+W + + + R + + F DG + DG
Sbjct: 349 ATCA-KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGR 407
Query: 400 EVVHIKDRKEV-IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSK----SLSFI 454
+ I + + + + + D + G +G V V+ + + +K+ E K S+S I
Sbjct: 408 LMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCI 467
Query: 455 ----------------THIDWSLDSKYLQTNDGAGERLF----YRMPSGKPLTSKEEIKG 494
T I W L + + LF Y + +TS + K
Sbjct: 468 RVKRNNEECVTASTDGTCIIWDL-VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKI 526
Query: 495 IPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGA 554
W + E+ G + IN +D V+G + LVK++ + G
Sbjct: 527 AYWEVFDGTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVKVWDY---NEGE 578
Query: 555 KFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRF 593
VGHS ++T +R S Q+++S AD ++ +W++
Sbjct: 579 VTHVGVGHSGNITRIRISPGNQYIVSV-SADGAILRWKY 616
Score = 73.9 bits (180), Expect = 1e-12
Identities = 141/648 (21%), Positives = 246/648 (37%), Gaps = 105/648 (16%)
Query: 677 LKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIH 736
L+L + G+ G+ + ++Y + ++ Q GH +++ L I
Sbjct: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
Query: 737 PVKDYVATGQV---GRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLD 793
+Y+A+GQV G A I +WD + + L+ L H+ + AL FS + LVS+G
Sbjct: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAFSPNDLYLVSLGGP 132
Query: 794 DFHSIVFWDWKKGEKIATTR------GHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAG 847
D S+V W K + I + G+ + +C + +T G I+ W+
Sbjct: 133 DDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD---EMFMTAGNGTIRVWEL-- 187
Query: 848 GGFTSKR--GTFGSVGKLE-TMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDG 904
+++ T G+L+ +M + + + G TGDI L T G
Sbjct: 188 -DLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLT---DVG 243
Query: 905 PVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLL---------- 954
P ++L + RCLK + L S GLL
Sbjct: 244 PAKDKFSLGVSAI----------------RCLKMGGL----LVGSGAGLLVFCKSPGYKP 283
Query: 955 ---LEDNPSIRAITL-GHGH-ILVGTKNGEILEIDKSG-PMTLLVQGH---MEGEVWGLA 1005
++ I +ITL G GH LVGT+ I + + TL+ H +E V+
Sbjct: 284 IKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFG 343
Query: 1006 AHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFL 1065
L CA K +R+W S+ +L + F DGK++ NDG
Sbjct: 344 TAELFATCA----KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIR 399
Query: 1066 VVNADTVEDMVSFHHRKEM-ISDIKFSKDTGKYL----------------------AVAS 1102
+T M ++ + ++ I + D + + A+
Sbjct: 400 AFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKE 459
Query: 1103 HDNFVDIYNVLTSKRVGICKGASSYITHIDWD----SRGKLLQVNSGAREQLFFEAPRGK 1158
H + V V + C AS+ T I WD R +++ N+ Q P
Sbjct: 460 HKSSVSCIRVKRNNEE--CVTASTDGTCIIWDLVRLRRNQMILANT--LFQCVCYHPEEF 515
Query: 1159 RHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVK 1218
+ I ++ + W+ + + EG S +N +T++ TG + VK
Sbjct: 516 QIITSGTDRKIAYWEVFDGTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVK 570
Query: 1219 LFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
++ Y +G+ VGHS ++T +R + +++V AD A++ W
Sbjct: 571 VWDYN-EGEVTHVG--VGHSGNITRIRISPGNQYIVSV-SADGAILRW 614
Score = 69.7 bits (169), Expect = 3e-11
Identities = 134/650 (20%), Positives = 240/650 (36%), Gaps = 98/650 (15%)
Query: 1360 VEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILC 1419
V EL LD V G+ G L D +I+ ++Q ++T Q+F H +++ C
Sbjct: 11 VAELELDAVIGFNGH-VPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSC 69
Query: 1420 LTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVS 1479
L +++ +Y + +G I +WD + L+ L H + + FS LVS
Sbjct: 70 LAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAFSPNDLYLVS 128
Query: 1480 VGVDPEHTITVWRWQEGAKVA---SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA 1536
+G + ++ VW + + + G ++ V F D F++ G ++ W L
Sbjct: 129 LGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL- 187
Query: 1537 GSALLYKK--GVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAH 1594
L +K G K M ++ + G GD+ R
Sbjct: 188 --DLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNP----RTKLLTD 241
Query: 1595 TGPVFTMYTTLRDGL--IVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSV 1652
GP ++ + + GG + G V K + QL+ G
Sbjct: 242 VGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGG----ITSIT 297
Query: 1653 CRGKG-KILVGTKDGEIIEVGEKNAASNILIDGHME---------GEIWGLATHPSKDL- 1701
RG+G + LVGT++ I V + ++ H + G AT KD+
Sbjct: 298 LRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIR 357
Query: 1702 -------------------------------FISASNDGTARIWDLADKKLLNKVSLGH- 1729
ISA NDG R + +L+ ++ H
Sbjct: 358 VWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHR 417
Query: 1730 -AARCAAYSPDGEMVAIGMKNGEFVILLV--NSLKVWGKKRDRKSAIQDIRISPDNRFLA 1786
A + D + V G GE + + + K+ ++ KS++ IR+ +N
Sbjct: 418 IGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECV 477
Query: 1787 VGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPL 1846
S++ T +DL R+ + I + + + Q+ T R++
Sbjct: 478 TASTDGTCIIWDLV------RLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKI----A 527
Query: 1847 GKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLV 1906
+V + VI ++ + S+ G + +T G++ VTG + LV
Sbjct: 528 YWEVFDGTVIRELEGSLSGSINGMD------------------ITQEGVHFVTGGNDHLV 569
Query: 1907 KLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1956
K++D+ E H GHS ++T IR S ++Y+VS D ++ W+
Sbjct: 570 KVWDY--NEGEVTHVG-VGHSGNITRIRISPGNQYIVSVSADG-AILRWK 615
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 72.0 bits (175), Expect = 5e-12
Identities = 64/246 (26%), Positives = 113/246 (45%), Gaps = 29/246 (11%)
Query: 36 VVYFVAGVGVVYNTREHSQK-FFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYN 94
V Y V V+ + +E+ Q+ F + +LA PD + TG+ G P + IWD
Sbjct: 85 VAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEE 144
Query: 95 VQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIF 154
V+ + H +GVAC+AF + + + S+G + +WDW+K ++AS S R+
Sbjct: 145 KNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVAS-NKVSCRVI 202
Query: 155 DISWDPYQPNRVVSCGVKHIKFWTL---CGNALTAKRGIFGKTGDL----QTILC-LACA 206
+S+ + V+ G +H++FW L +T+ + G++G L I C +AC
Sbjct: 203 ALSFSE-DSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACG 261
Query: 207 KED-------ITYSGAL---NGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRD 256
+ ++YSG L N + K +NL ++ + +E G D
Sbjct: 262 RGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSC-------LCVSQELIFCGCTD 314
Query: 257 GCIRLW 262
G +R++
Sbjct: 315 GIVRIF 320
Score = 66.6 bits (161), Expect = 2e-10
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 21/193 (10%)
Query: 700 GEVVYHIAAVAVVYNRQQHSQR-LYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDT 758
G V Y V V+ + +++ Q+ ++ + +L P Y+ TG+ G A+ +WD
Sbjct: 83 GHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDV 142
Query: 759 QTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDK 818
+ ++ + G H+ GV + FS + K +VS+G + WDWKK +A+ +
Sbjct: 143 EEKNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNK----- 196
Query: 819 IFVVKCN------PHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYG 872
V C VTVG +H++FW T T VG+ + G
Sbjct: 197 ---VSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGIL-----G 248
Query: 873 RMEDLVFSGAATG 885
+ + +F G A G
Sbjct: 249 ELHNNIFCGVACG 261
Score = 61.6 bits (148), Expect = 7e-09
Identities = 39/128 (30%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 1432 VATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVW 1491
+ T + G P++ IWD K+ ++ + H GV + FS K +VS+G + + VW
Sbjct: 126 IVTGENGHRPAVRIWDVEEKNQVAEM-LGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVW 184
Query: 1492 RWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSA---------LLY 1542
W++ VAS R+ + F DS + FV+VG +H++FW L S L+
Sbjct: 185 DWKKDIVVASNKVSC-RVIALSFSEDS-SYFVTVGNRHVRFWFLEVSTETKVTSTVPLVG 242
Query: 1543 KKGVIGSL 1550
+ G++G L
Sbjct: 243 RSGILGEL 250
Score = 42.0 bits (97), Expect = 0.006
Identities = 58/267 (21%), Positives = 105/267 (39%), Gaps = 34/267 (12%)
Query: 1697 PSKDLFISASNDGTARIWDLADKKLLNKVSLGHA-ARCAAYS-PDGEMVAIGMKNGEFVI 1754
P S G RI +L L KV A C YS P+ + + + + +I
Sbjct: 502 PDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLI 561
Query: 1755 LLVNSLKVWGKKR---DRKSAIQDIRISPDNRFLAVG-SSEHTVDFYDLTQGTNLNRIGY 1810
++N K + ++ D S+I I+ + + + ++ ++ F QG++
Sbjct: 562 HVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVR 621
Query: 1811 CKDIP--SFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVL 1868
+ + + MD KY+ V+ +V+ GKQ +K S
Sbjct: 622 THHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQ-------KKCYKGS----- 669
Query: 1869 GDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSA 1928
D+ + V +G + T + + DF E AK FGHS
Sbjct: 670 ----------QGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAK---MFGHSE 716
Query: 1929 HVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
+T+++F+YD ++++ GD C VF+W
Sbjct: 717 IITSMKFTYDCHHLITVSGDSC-VFIW 742
Score = 32.0 bits (71), Expect = 6.1
Identities = 27/122 (22%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQF 1522
K ++ + FS GK +V+ + +W +E +VA GH + V F P+
Sbjct: 112 KSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNM-KHI 170
Query: 1523 VSVGVKH---MKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVY 1579
VS+G +H + W +KK ++ + + +++++F ++ F N V
Sbjct: 171 VSMGYQHDMVLNVWD-------WKKDIVVASNKVSCR-VIALSFSEDSSYFVTVGNRHVR 222
Query: 1580 VW 1581
W
Sbjct: 223 FW 224
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 72.0 bits (175), Expect = 5e-12
Identities = 64/246 (26%), Positives = 113/246 (45%), Gaps = 29/246 (11%)
Query: 36 VVYFVAGVGVVYNTREHSQK-FFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYN 94
V Y V V+ + +E+ Q+ F + +LA PD + TG+ G P + IWD
Sbjct: 85 VAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEE 144
Query: 95 VQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIF 154
V+ + H +GVAC+AF + + + S+G + +WDW+K ++AS S R+
Sbjct: 145 KNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVAS-NKVSCRVI 202
Query: 155 DISWDPYQPNRVVSCGVKHIKFWTL---CGNALTAKRGIFGKTGDL----QTILC-LACA 206
+S+ + V+ G +H++FW L +T+ + G++G L I C +AC
Sbjct: 203 ALSFSE-DSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACG 261
Query: 207 KED-------ITYSGAL---NGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRD 256
+ ++YSG L N + K +NL ++ + +E G D
Sbjct: 262 RGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSC-------LCVSQELIFCGCTD 314
Query: 257 GCIRLW 262
G +R++
Sbjct: 315 GIVRIF 320
Score = 66.6 bits (161), Expect = 2e-10
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 21/193 (10%)
Query: 700 GEVVYHIAAVAVVYNRQQHSQR-LYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDT 758
G V Y V V+ + +++ Q+ ++ + +L P Y+ TG+ G A+ +WD
Sbjct: 83 GHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDV 142
Query: 759 QTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDK 818
+ ++ + G H+ GV + FS + K +VS+G + WDWKK +A+ +
Sbjct: 143 EEKNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNK----- 196
Query: 819 IFVVKCN------PHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYG 872
V C VTVG +H++FW T T VG+ + G
Sbjct: 197 ---VSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGIL-----G 248
Query: 873 RMEDLVFSGAATG 885
+ + +F G A G
Sbjct: 249 ELHNNIFCGVACG 261
Score = 61.6 bits (148), Expect = 7e-09
Identities = 39/128 (30%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 1432 VATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVW 1491
+ T + G P++ IWD K+ ++ + H GV + FS K +VS+G + + VW
Sbjct: 126 IVTGENGHRPAVRIWDVEEKNQVAEM-LGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVW 184
Query: 1492 RWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSA---------LLY 1542
W++ VAS R+ + F DS + FV+VG +H++FW L S L+
Sbjct: 185 DWKKDIVVASNKVSC-RVIALSFSEDS-SYFVTVGNRHVRFWFLEVSTETKVTSTVPLVG 242
Query: 1543 KKGVIGSL 1550
+ G++G L
Sbjct: 243 RSGILGEL 250
Score = 42.0 bits (97), Expect = 0.006
Identities = 58/267 (21%), Positives = 105/267 (39%), Gaps = 34/267 (12%)
Query: 1697 PSKDLFISASNDGTARIWDLADKKLLNKVSLGHA-ARCAAYS-PDGEMVAIGMKNGEFVI 1754
P S G RI +L L KV A C YS P+ + + + + +I
Sbjct: 502 PDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLI 561
Query: 1755 LLVNSLKVWGKKR---DRKSAIQDIRISPDNRFLAVG-SSEHTVDFYDLTQGTNLNRIGY 1810
++N K + ++ D S+I I+ + + + ++ ++ F QG++
Sbjct: 562 HVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVR 621
Query: 1811 CKDIP--SFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVL 1868
+ + + MD KY+ V+ +V+ GKQ +K S
Sbjct: 622 THHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQ-------KKCYKGS----- 669
Query: 1869 GDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSA 1928
D+ + V +G + T + + DF E AK FGHS
Sbjct: 670 ----------QGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAK---MFGHSE 716
Query: 1929 HVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
+T+++F+YD ++++ GD C VF+W
Sbjct: 717 IITSMKFTYDCHHLITVSGDSC-VFIW 742
Score = 32.0 bits (71), Expect = 6.1
Identities = 27/122 (22%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQF 1522
K ++ + FS GK +V+ + +W +E +VA GH + V F P+
Sbjct: 112 KSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNM-KHI 170
Query: 1523 VSVGVKH---MKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVY 1579
VS+G +H + W +KK ++ + + +++++F ++ F N V
Sbjct: 171 VSMGYQHDMVLNVWD-------WKKDIVVASNKVSCR-VIALSFSEDSSYFVTVGNRHVR 222
Query: 1580 VW 1581
W
Sbjct: 223 FW 224
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 67.8 bits (164), Expect = 1e-10
Identities = 123/585 (21%), Positives = 219/585 (37%), Gaps = 115/585 (19%)
Query: 105 HTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPN 164
H V+C +F +DG LA+ G D ++ +C WD R P P
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRD-RSLLC-WDVRT--------------------PKTPV 2097
Query: 165 RVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWK 224
+ S H + T C A K+++ S + +G + +W
Sbjct: 2098 LIHSFPACHRDWVTGC-----------------------AWTKDNLLISCSSDGSVGLWD 2134
Query: 225 GLNLVRTIQG-AHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKG 283
+ R Q H + + ++ A EE + RDG +++WD +T I +
Sbjct: 2135 PESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
Query: 284 LSIRSVCWKADRLLAGTQDSEIFEVIV-----RERDKPMLILQGHC----EGELWALALH 334
++ + AG SE+ V V P+L+ Q H G + A A+
Sbjct: 2195 AAM-------EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVS 2247
Query: 335 PKKPLAVTGSDDRSVRLWSL---ADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFI 391
L +T S+D SVRLW + AD I R + AV +VA++PDGS G + G I
Sbjct: 2248 ETSGLMLTASEDGSVRLWQVPKEADDTCIPRSS--AAVTAVAWAPDGSMAVSGNQAGELI 2305
Query: 392 VLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECS--- 448
+ + + V I + +S ++ + +++ + ++ G S
Sbjct: 2306 LWQ---EAKAVATAQAPGHIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHL 2362
Query: 449 -----KSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCV 503
+ L +T +DW+ D +L + +K ++K + C+
Sbjct: 2363 NRILQEDLGVLTSLDWAPDGHFL-------------------ILAKADLKLL------CM 2397
Query: 504 K-GPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGH 562
K G S IW YTE I S Y VL D + F K +F + +
Sbjct: 2398 KPGDAPSEIWSSYTENPMILSTHKEYGIFVLQPKDP----GVLSFLRQKESGEFEERLNF 2453
Query: 563 SAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGMLETAPQE--GGADSYSEESD 620
++ N S + S F +G+ + + +P+ + + ++++
Sbjct: 2454 DINLENP--SRTLISITQAKPESESSFLCA-SSDGILWNLAKCSPEGEWTTGNMWQKKAN 2510
Query: 621 SDLSDVPELDSDI--EQEAQINYDRQVYKEDLPQLKQQSKEKNHA 663
+ + P D E +A ++ D + E P LK + + K H+
Sbjct: 2511 TPETQTPGTDPSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHS 2555
Score = 61.2 bits (147), Expect = 9e-09
Identities = 135/613 (22%), Positives = 241/613 (39%), Gaps = 110/613 (17%)
Query: 750 DAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKI 809
D + +WD Q C L HQ + S D + L +V L + WD +G+ +
Sbjct: 1738 DGLLELWDLQH-GCRVLQTKAHQYQITGCCLSPDCRLLATVCLGG--CLKLWDTVRGQ-L 1793
Query: 810 ATTRGHKDKIFVVKCNPHHVDKLVTVG--IKHIKFWQQAGGGFTSKRGTFGSVGKLETMM 867
A + + V +P +++ G I F+Q G T G G+ + T+
Sbjct: 1794 AFQHTYPKSLNCVAFHPE--GQVIATGSWAGSISFFQVDGLKVTKDLGAPGA--SIRTLA 1849
Query: 868 ------CVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKG--FVTG 919
V+ GR++ +V +++ W++ L AH G V A L G +T
Sbjct: 1850 FNVPGGVVAVGRLDSMV-------ELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTA 1902
Query: 920 GKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSI----RAITLGHGHILVGT 975
G+DG V++W R + +LS + L D + RA + I G+
Sbjct: 1903 GEDGKVQVWSGSLGR--PRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGS 1960
Query: 976 K--NGEILEIDKSGPMTL----LVQGHMEGEVWGLA---------------AHPLL---- 1010
+ G+ L++ S L LV G +G + G A P+L
Sbjct: 1961 QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLAT 2020
Query: 1011 --PICATVSDDKTLRIWE---LSAQHRM------LAVRKLKKGGRCCAFSPDGKALAVGL 1059
+ A+ S+D T+++W L+ H+ +R + CC+FS DG +LA G
Sbjct: 2021 SQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGG 2080
Query: 1060 NDGSFLVVNADTVEDMVSFHH----RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS 1115
D S L + T + V H ++ ++ ++KD L S D V +++ +
Sbjct: 2081 RDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD--NLLISCSSDGSVGLWDPESG 2138
Query: 1116 KRVGICKGASSYITHID-----------------WDSRG-KLLQVNSGAREQLFFEAPRG 1157
+R+G G S ++ + WD +G +L + + + A
Sbjct: 2139 QRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAME 2198
Query: 1158 KRHIIRPSE---IEKIEWDTWTCVLGPTCEGIWPAHSDI---TDVNAASLTKDCSLLATG 1211
R +P + + D T + P + H+ + V AA++++ L+ T
Sbjct: 2199 PRAAGQPGSELLVVTVGLDGATRLWHPLL--VCQTHTLLGHSGPVRAAAVSETSGLMLTA 2256
Query: 1212 DDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFV 1271
+ G V+L+ P + + SA VT V W + S+ ++ G L++W
Sbjct: 2257 SEDGSVRLWQVPKEADDTCIPR---SSAAVTAVAWAPDGSMAVS-GNQAGELILW----- 2307
Query: 1272 GTQESKLVDSEES 1284
QE+K V + ++
Sbjct: 2308 --QEAKAVATAQA 2318
Score = 55.5 bits (132), Expect = 5e-07
Identities = 75/332 (22%), Positives = 127/332 (38%), Gaps = 52/332 (15%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQ---HQRGVCALDFS 781
GH+ + + +ATG GRD ++ WD +T K L+ H+ V ++
Sbjct: 2059 GHEGPVSCCSFSTDGGSLATG--GRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
Query: 782 ADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIK 841
D L+S D S+ WD + G+++ GH+ + V HV + G +K
Sbjct: 2117 KDN-LLISCSSDG--SVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGT--LK 2171
Query: 842 FWQQAGGGFTSKRGTFGSVGKLETMM---CVSYGRMEDLVFSGAATGDIFIWKDILLLK- 897
W G TS G + M E LV + G +W +L+ +
Sbjct: 2172 VWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
Query: 898 -TVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD---DMFERCLKTYAIKRSALSTSSK 951
T+ H GPV A + +T +DG V LW + + C+ + +A++ +
Sbjct: 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291
Query: 952 GLLLEDNPSIRAITLGHGHILVGTKNGE-ILEIDKSGPMTLLVQGHMEGEVWGLAAHPLL 1010
G + + G + GE IL + T GH+ +W +AH
Sbjct: 2292 GSM----------------AVSGNQAGELILWQEAKAVATAQAPGHIGALIWS-SAHTFF 2334
Query: 1011 PICATVSDDKTLRIWELSAQHRMLAVRKLKKG 1042
+S D+ + W++ KL+KG
Sbjct: 2335 ----VLSADEKISEWQV----------KLRKG 2352
Score = 44.3 bits (103), Expect = 0.001
Identities = 54/260 (20%), Positives = 95/260 (36%), Gaps = 12/260 (4%)
Query: 1438 GTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGA 1497
G S+ WD T T ++ F + +++ A K + + + ++ +W + G
Sbjct: 2080 GRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
Query: 1498 KVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLG--AAKM 1555
++ GH + V + G +K W G L G + AA M
Sbjct: 2140 RLGQFLGHQSAVSAVAAVEEHVVSVSRDGT--LKVWDHQGVELTSIPAHSGPISHCAAAM 2197
Query: 1556 QTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRL-VAKAHTGPVFTMYTTLRDGLIVTGG 1614
+ + G+ L T ++G +W + + H+GPV + GL++T
Sbjct: 2198 EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTAS 2257
Query: 1615 KERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEK 1674
E G+V+LW + + V V G + G + GE+I E
Sbjct: 2258 ------EDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS-GNQAGELILWQEA 2310
Query: 1675 NAASNILIDGHMEGEIWGLA 1694
A + GH+ IW A
Sbjct: 2311 KAVATAQAPGHIGALIWSSA 2330
Score = 42.7 bits (99), Expect = 0.003
Identities = 37/173 (21%), Positives = 69/173 (39%), Gaps = 7/173 (4%)
Query: 1640 LETGQLVECVRSVCRGKGKILVGTKD-------GEIIEVGEKNAASNILIDGHMEGEIWG 1692
L T Q + V S C G L + D ++E+ + +L + +I G
Sbjct: 1705 LRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITG 1764
Query: 1693 LATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEF 1752
P L + G ++WD +L + + + C A+ P+G+++A G G
Sbjct: 1765 CCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSI 1824
Query: 1753 VILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNL 1805
V+ LKV ++I+ + + +AVG + V+ + +G L
Sbjct: 1825 SFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARL 1877
Score = 42.0 bits (97), Expect = 0.006
Identities = 35/142 (24%), Positives = 60/142 (42%), Gaps = 13/142 (9%)
Query: 1623 GAVKLWDQEMKRCRAFQLETGQLVECV-----RSVCRGKGKILVGTK--DGEIIEVGEKN 1675
G +K+WD + + +G + C R+ + ++LV T DG
Sbjct: 2168 GTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL 2227
Query: 1676 AASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDL---ADKKLLNKVSLGHAAR 1732
+ GH G + A + L ++AS DG+ R+W + AD + + S A
Sbjct: 2228 VCQTHTLLGH-SGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA--AVT 2284
Query: 1733 CAAYSPDGEMVAIGMKNGEFVI 1754
A++PDG M G + GE ++
Sbjct: 2285 AVAWAPDGSMAVSGNQAGELIL 2306
Score = 36.2 bits (82), Expect = 0.32
Identities = 47/218 (21%), Positives = 87/218 (39%), Gaps = 11/218 (5%)
Query: 226 LNLVRTIQGAHSAGI---FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYK 282
LN RT++ S+ + S F+T G+ + T + +DLR ++
Sbjct: 1657 LNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAV---GTANGTVYLLDLRTWQEEKS 1713
Query: 283 GLS----IRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKP 338
+S I + + +D L T + E+ + +L + H + ++ L P
Sbjct: 1714 VVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAH-QYQITGCCLSPDCR 1772
Query: 339 LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDM 398
L T ++LW L + +++ VAF P+G +A G GS +V +
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGL 1832
Query: 399 TEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYA 436
+ I + F+ G +AVG D V+++A
Sbjct: 1833 KVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWA 1870
Score = 35.8 bits (81), Expect = 0.42
Identities = 73/312 (23%), Positives = 122/312 (39%), Gaps = 30/312 (9%)
Query: 94 NVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWD---WRKGKLLASATGHS 150
N Q+ SL V + A +AF ++GQR A+VG A TV + D W++ K + S
Sbjct: 1665 NQQSSSLSLAVSSSPTA-VAFSTNGQR-AAVGT-ANGTVYLLDLRTWQEEKSVVSGCDGI 1721
Query: 151 DRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDI 210
+S D ++ ++ W L R + K Q C +
Sbjct: 1722 SACLFLSDDTL----FLTAFDGLLELWDLQHGC----RVLQTKAHQYQITGCCLSPDCRL 1773
Query: 211 TYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKP 268
+ L G + +W + Q + + + EG ATG G I + D
Sbjct: 1774 LATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLK 1833
Query: 269 ITKIDLRETEQGYKGLSIRSVCWKADR--LLAGTQDSEIFEVIVRERDKPMLILQGHCEG 326
+TK + G G SIR++ + + G DS + E+ + H
Sbjct: 1834 VTK------DLGAPGASIRTLAFNVPGGVVAVGRLDSMV-ELWAWREGARLAAFPAHHGF 1886
Query: 327 ELWALALHPKKPLAVTGSDDRSVRLWSLA---DHALIARCNMEEAVRSVAFSPDGSQLAL 383
AL LH L G D + V++WS + + ++ A+ SVA SPDG ++A+
Sbjct: 1887 VAAALFLHAGCQLLTAGEDGK-VQVWSGSLGRPRGHLGSLSLSPAL-SVALSPDGDRVAV 1944
Query: 384 GMKDGSFIVLRV 395
G + + ++
Sbjct: 1945 GYRADGIRIYKI 1956
Score = 32.7 bits (73), Expect = 3.6
Identities = 39/173 (22%), Positives = 65/173 (37%), Gaps = 19/173 (10%)
Query: 948 TSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAH 1007
+SS L + +P+ A + VGT NG + +D T + + G++A
Sbjct: 1668 SSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLR---TWQEEKSVVSGCDGISA- 1723
Query: 1008 PLLPICATVSDDKT--------LRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGL 1059
C +SDD L +W+L R+L + + C SPD + LA
Sbjct: 1724 -----CLFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVC 1778
Query: 1060 NDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNV 1112
G + DTV ++F H + G+ +A S + + V
Sbjct: 1779 LGGCLKL--WDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 67.4 bits (163), Expect = 1e-10
Identities = 66/257 (25%), Positives = 106/257 (41%), Gaps = 25/257 (9%)
Query: 64 IISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLAS 123
I+S PD V +G + ICI D+ N+ TVS++KD HT + FD D QR+AS
Sbjct: 189 IVSCKFSPDGKYVVSG-FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVAS 247
Query: 124 VGLDAKNTVCIWD-WRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTL--- 179
V LD + IWD + LL HS+ I + + S K++K W +
Sbjct: 248 VSLD--RCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTG 305
Query: 180 ----CGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQ-G 234
CG +T +G G C SG + + +W R +
Sbjct: 306 EFRNCGACVTLMQGHEGSVSS-----CHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360
Query: 235 AHSAGIFSMYAC--EEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWK 292
H+ + + ++ + +D +RLW + + I +I L + GL ++ C +
Sbjct: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLW--NIEEIDEIPLVIKYKKAVGLKLKQ-CER 417
Query: 293 ADR---LLAGTQDSEIF 306
DR + SE+F
Sbjct: 418 CDRPFSIFKSDTSSEMF 434
Score = 44.7 bits (104), Expect = 0.001
Identities = 56/253 (22%), Positives = 102/253 (40%), Gaps = 25/253 (9%)
Query: 341 VTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMK-DGSFIVLRVRDMT 399
+ S D++VR W L L+ + + + S FSPDG + G D ++ ++T
Sbjct: 161 IAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENIT 220
Query: 400 EVVHIKD-RKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHID 458
V IKD I F PD +A S D + ++ V + + + I++
Sbjct: 221 TVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCC 280
Query: 459 WSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEV 518
++ +L T+ + + +G E + A T ++G E S
Sbjct: 281 FTFSGHFLCTSSWDKNLKIWNVHTG-------EFRNC-GACVTLMQGHEGS--------- 323
Query: 519 TDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWV 578
++S +SS L+SG G + + G + GH+ V +V S++ +W+
Sbjct: 324 --VSSCHFARDSSFLISG---GFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWI 378
Query: 579 LSTGGADHSVFQW 591
LS D ++ W
Sbjct: 379 LS-ASKDRTMRLW 390
Score = 41.6 bits (96), Expect = 0.008
Identities = 32/105 (30%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 1703 ISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIG--MKNGEFVILLVNSL 1760
I+AS D T R WDL KLL KV +SPDG+ V G + +G ++ N
Sbjct: 161 IAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENIT 220
Query: 1761 KVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNL 1805
V K +I PD++ +A S + + +D+T L
Sbjct: 221 TVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
Score = 38.5 bits (88), Expect = 0.065
Identities = 39/145 (26%), Positives = 67/145 (46%), Gaps = 19/145 (13%)
Query: 1017 SDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLN-DGSFLVVNAD--TVE 1073
S DKT+R W+L + VR C FSPDGK + G + D +++A+ T
Sbjct: 164 SYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTV 222
Query: 1074 DMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLT-SKRVGICKGASSYITHI- 1131
++ HH + I+ F D+ + +A S D + I++V + + + I K S+ I++
Sbjct: 223 SVIKDHHTRS-ITSCCFDPDSQR-VASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCC 280
Query: 1132 -----------DWDSRGKLLQVNSG 1145
WD K+ V++G
Sbjct: 281 FTFSGHFLCTSSWDKNLKIWNVHTG 305
Score = 37.7 bits (86), Expect = 0.11
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 9/79 (11%)
Query: 750 DAAIHVWDTQTLK------CLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDW 803
D + +W+ T + C++L++G H+ V + F+ D L+S G D ++ WD
Sbjct: 294 DKNLKIWNVHTGEFRNCGACVTLMQG-HEGSVSSCHFARDSSFLISGGFD--RTVAIWDV 350
Query: 804 KKGEKIATTRGHKDKIFVV 822
+G + + +GH D + V
Sbjct: 351 AEGYRKLSLKGHNDWVMDV 369
Score = 36.6 bits (83), Expect = 0.25
Identities = 50/216 (23%), Positives = 84/216 (38%), Gaps = 42/216 (19%)
Query: 1770 KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKY 1829
K+ + + I+ D+ + S + TV +DL G L ++ Y +F++ FS DGKY
Sbjct: 145 KAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRY----DTFIVSCKFSPDGKY 200
Query: 1830 IQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWT------------SVLGDEVIGIWP 1877
V +G + + +T VI+ S T SV D I IW
Sbjct: 201 --VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 258
Query: 1878 RNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYF------------- 1924
+ +T A N ++ F F CT + K+ + +
Sbjct: 259 VT---SQATLLTITKAHSNAISNCCFTFSG--HFLCTSSWDKNLKIWNVHTGEFRNCGAC 313
Query: 1925 -----GHSAHVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
GH V++ F+ D +++S GG D +V +W
Sbjct: 314 VTLMQGHEGSVSSCHFARDSSFLIS-GGFDRTVAIW 348
Score = 35.8 bits (81), Expect = 0.42
Identities = 44/195 (22%), Positives = 76/195 (38%), Gaps = 33/195 (16%)
Query: 1633 KRCRAFQLETGQLVECVR-----SVCR--GKGKILVGTKDGE--IIEVGEKNAASNILID 1683
K RA+ LETG+L+ VR C+ GK +V D + I + +N + +I
Sbjct: 167 KTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIK 226
Query: 1684 GHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGH--AARCAAYSPDGE 1741
H I P S S D +IWD+ + L ++ H A ++ G
Sbjct: 227 DHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH 286
Query: 1742 MVAIGMKNGEFVILLVNSLKVW----GKKRD----------RKSAIQDIRISPDNRFLAV 1787
+ + +LK+W G+ R+ + ++ + D+ FL
Sbjct: 287 FLCTSSWD--------KNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLIS 338
Query: 1788 GSSEHTVDFYDLTQG 1802
G + TV +D+ +G
Sbjct: 339 GGFDRTVAIWDVAEG 353
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 66.6 bits (161), Expect = 2e-10
Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
R +GH +I SL HP ++VA+G +D I +WD + C+ +G H + V L F
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASG--SQDTNIKLWDIRRKGCVFRYRG-HSQAVRCLRF 155
Query: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI 840
S DGK L S D H++ WD G+ ++ GH + VV+ +P+ + I
Sbjct: 156 SPDGKWLASAA--DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
Query: 841 KFW 843
+FW
Sbjct: 214 RFW 216
Score = 65.5 bits (158), Expect = 5e-10
Identities = 57/188 (30%), Positives = 90/188 (47%), Gaps = 18/188 (9%)
Query: 208 EDITYSGALNGDIYVW--KGLNLVRTIQGAHSAGIFSM--YACEEGFATGGRDGCIRLWD 263
E++ +G+ +G I VW + ++RT+ G H A I S+ + E A+G +D I+LWD
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMG-HKANICSLDFHPYGEFVASGSQDTNIKLWD 133
Query: 264 TDFKPITKIDLRETEQGYKGLS--IRSVCWKAD-RLLAGTQDSEIFEVIVRERDKPMLIL 320
I + Y+G S +R + + D + LA D ++ K M
Sbjct: 134 --------IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 321 QGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEA-VRSVAFSPDGS 379
GH G + + HP + L +GS DR++R W L +++ E VRSV F+PDG
Sbjct: 186 PGHT-GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGC 244
Query: 380 QLALGMKD 387
L G +D
Sbjct: 245 CLYSGCQD 252
Score = 62.4 bits (150), Expect = 4e-09
Identities = 44/159 (27%), Positives = 79/159 (49%), Gaps = 7/159 (4%)
Query: 1649 VRSVCRGK--GKILVGTKDGEIIEVGEKNAASNIL-IDGHMEGEIWGLATHPSKDLFISA 1705
V S+ GK G++L D + + N + I+ + GH + + + ++L ++
Sbjct: 23 VSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTS-PVESVRLNTPEELIVAG 81
Query: 1706 SNDGTARIWDLADKKLLNKVSLGHAARCAA--YSPDGEMVAIGMKNGEFVILLVNSLKVW 1763
S G+ R+WDL K+L + +GH A + + P GE VA G ++ + +
Sbjct: 82 SQSGSIRVWDLEAAKILRTL-MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCV 140
Query: 1764 GKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQG 1802
+ R A++ +R SPD ++LA + +HTV +DLT G
Sbjct: 141 FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG 179
Score = 58.9 bits (141), Expect = 5e-08
Identities = 42/144 (29%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 58 LGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSD 117
+GH +I SL HP VA+G ++ I +WD V + H+ V CL F D
Sbjct: 102 MGHKANICSLDFHPYGEFVASGS--QDTNIKLWDIRRKGCVFRYRG-HSQAVRCLRFSPD 158
Query: 118 GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFW 177
G+ LAS D +TV +WD GK+++ GH+ + + + P + + I+FW
Sbjct: 159 GKWLASAADD--HTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Query: 178 TLCGNALTAKRGIFGKTGDLQTIL 201
L I G+ G ++++L
Sbjct: 217 DL--EKFQVVSCIEGEPGPVRSVL 238
Score = 47.8 bits (112), Expect = 1e-04
Identities = 60/265 (22%), Positives = 107/265 (40%), Gaps = 25/265 (9%)
Query: 890 WKDILLLKTVKAHDGPVFAMY---ALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSAL 946
WK L+ + AH V ++ A + TGG D V LW C+ + S +
Sbjct: 11 WK----LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
Query: 947 STSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTL-LVQGHMEGEVWGLA 1005
S+R T I+ G+++G I D L + GH + + L
Sbjct: 67 E------------SVRLNT-PEELIVAGSQSGSIRVWDLEAAKILRTLMGH-KANICSLD 112
Query: 1006 AHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFL 1065
HP A+ S D +++W++ + + R + RC FSPDGK LA +D +
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
Query: 1066 VVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGAS 1125
+ + + M F ++ ++F + LA S D + +++ + V +G
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEKFQVVSCIEGEP 231
Query: 1126 SYITHIDWDSRGKLLQVNSGAREQL 1150
+ + ++ G L SG ++ L
Sbjct: 232 GPVRSVLFNPDGCCLY--SGCQDSL 254
Score = 47.8 bits (112), Expect = 1e-04
Identities = 52/185 (28%), Positives = 77/185 (41%), Gaps = 28/185 (15%)
Query: 1373 GFDCRNNLHYLNDGADIIFHTAAAGIVQNLS---------TGSQS-----FYLEHTDDIL 1418
G DCR NL +N I+ T V+++ GSQS + LE +
Sbjct: 40 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 99
Query: 1419 CL--------TVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINF 1470
L +++ HP Y VA+ T +I +WD K + R HS+ V + F
Sbjct: 100 TLMGHKANICSLDFHP-YGEFVASGSQDT--NIKLWDIRRKGCVFRYRG-HSQAVRCLRF 155
Query: 1471 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHM 1530
S GK L S D HT+ +W G ++ GH + VVEF P+ + +
Sbjct: 156 SPDGKWLASAADD--HTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
Query: 1531 KFWTL 1535
+FW L
Sbjct: 214 RFWDL 218
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/121 (28%), Positives = 62/121 (51%), Gaps = 4/121 (3%)
Query: 317 MLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM--EEAVRSVAF 374
++ L GH + ++ L+ + L V GS S+R+W L + A I R M + + S+ F
Sbjct: 56 IMSLTGHTS-PVESVRLNTPEELIVAGSQSGSIRVWDL-EAAKILRTLMGHKANICSLDF 113
Query: 375 SPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDV 434
P G +A G +D + + +R V + + + ++FSPDG +LA ++D V +
Sbjct: 114 HPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKL 173
Query: 435 Y 435
+
Sbjct: 174 W 174
Score = 47.4 bits (111), Expect = 1e-04
Identities = 52/198 (26%), Positives = 83/198 (41%), Gaps = 29/198 (14%)
Query: 1625 VKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNIL-ID 1683
+KLWD K C Q V C+R GK L D +++ + A +
Sbjct: 129 IKLWDIRRKGCVFRYRGHSQAVRCLRF--SPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 1684 GHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV-SLGHAARCAAYSPDGEM 1742
GH G + + HP++ L S S+D T R WDL ++++ + R ++PDG
Sbjct: 187 GHT-GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCC 245
Query: 1743 VAIGMKNGE----------FVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEH 1792
+ G ++ F ++LVN WGK + D+ I D + + V S+
Sbjct: 246 LYSGCQDSLRVYGWEPERCFDVVLVN----WGK-------VADLAICND-QLIGVAFSQS 293
Query: 1793 TVDFY--DLTQGTNLNRI 1808
V Y DLT+ T +
Sbjct: 294 NVSSYVVDLTRVTRTGTV 311
Score = 43.9 bits (102), Expect = 0.002
Identities = 47/186 (25%), Positives = 79/186 (42%), Gaps = 11/186 (5%)
Query: 247 EEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWK--ADRLLAGTQDSE 304
EE G + G IR+WD + I + T G+K +I S+ + + + +G+QD+
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILR-----TLMGHKA-NICSLDFHPYGEFVASGSQDTN 128
Query: 305 IFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN 364
I +R R + +GH + + L P + +DD +V+LW L +++
Sbjct: 129 IKLWDIR-RKGCVFRYRGHSQA-VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 365 MEEA-VRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYL 423
V V F P+ LA G D + + V I+ + + F+PDG L
Sbjct: 187 GHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Query: 424 AVGSND 429
G D
Sbjct: 247 YSGCQD 252
Score = 43.1 bits (100), Expect = 0.003
Identities = 59/254 (23%), Positives = 100/254 (39%), Gaps = 25/254 (9%)
Query: 58 LGHNDDIISLAL-HPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDS 116
+ H ++ SL L L+ATG G + + +W S N + HT V + ++
Sbjct: 17 VAHASNVSSLVLGKASGRLLATG--GDDCRVNLW-SINKPNCIMSLTGHTSPVESVRLNT 73
Query: 117 DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKF 176
+ + V ++ +WD K+L + GH I + + PY +IK
Sbjct: 74 PEELI--VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 177 WTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNG-DIYVW---KGLNLVRTI 232
W + K +F G Q + CL + + + A + + +W G +
Sbjct: 132 WD-----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 233 QGAHSAGIFSMYACEEGFATGGRDGCIRLWDTD-FKPITKIDLRETEQGYKGLSIRSVCW 291
+ + E A+G D IR WD + F+ ++ I E E G +RSV +
Sbjct: 187 GHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCI---EGEPG----PVRSVLF 239
Query: 292 KADR--LLAGTQDS 303
D L +G QDS
Sbjct: 240 NPDGCCLYSGCQDS 253
Score = 38.5 bits (88), Expect = 0.065
Identities = 30/127 (23%), Positives = 52/127 (40%), Gaps = 6/127 (4%)
Query: 339 LAVTGSDDRSVRLWSL-ADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRD 397
L TG DD V LWS+ + +++ V SV + + G + GS V +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 398 MTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ-----RYKKIGECSKSLS 452
+ + K I + F P G ++A GS D + ++ + + RY+ + + L
Sbjct: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Query: 453 FITHIDW 459
F W
Sbjct: 155 FSPDGKW 161
Score = 37.4 bits (85), Expect = 0.15
Identities = 46/214 (21%), Positives = 84/214 (39%), Gaps = 21/214 (9%)
Query: 724 LGHDDDILSLTIHPVKD-YVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSA 782
+ H ++ SL + +ATG G D +++W C+ L G H V ++ +
Sbjct: 17 VAHASNVSSLVLGKASGRLLATG--GDDCRVNLWSINKPNCIMSLTG-HTSPVESVRLNT 73
Query: 783 DGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIK--HI 840
+ +V+ SI WD + + + T GHK I + +P+ + V G + +I
Sbjct: 74 PEELIVAGSQSG--SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNI 129
Query: 841 KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDIL---LLK 897
K W K F G + + C+ + + S A + +W D+ ++
Sbjct: 130 KLWD-----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW-DLTAGKMMS 183
Query: 898 TVKAHDGP--VFAMYALDKGFVTGGKDGIVELWD 929
H GP V + + +G D + WD
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Score = 33.9 bits (76), Expect = 1.6
Identities = 27/155 (17%), Positives = 66/155 (42%), Gaps = 8/155 (5%)
Query: 1701 LFISASNDGTARIWDLADKKLLNKVSLGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVN 1758
L + +D +W + + ++ GH + + E++ G ++G + +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLT-GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 1759 SLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ-GTNLNRIGYCKDIPSF 1817
+ K+ K+ I + P F+A GS + + +D+ + G G+ + +
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC- 152
Query: 1818 VIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTE 1852
+ FS DGK++ + + ++ ++ GK ++E
Sbjct: 153 ---LRFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184
Score = 32.7 bits (73), Expect = 3.6
Identities = 24/72 (33%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 520 DINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVL 579
+I S+D + + SG +KL+ ++G FR Y GHS V +R+S D +W L
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFR-YRGHSQAVRCLRFSPDGKW-L 162
Query: 580 STGGADHSVFQW 591
++ DH+V W
Sbjct: 163 ASAADDHTVKLW 174
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 64.7 bits (156), Expect = 8e-10
Identities = 79/322 (24%), Positives = 126/322 (39%), Gaps = 42/322 (13%)
Query: 722 LYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQ-TLKCLSLLKGQHQRGVCALDF 780
L GH+ ++ HP +A+ G D I +W+ + LKG H V L +
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASA--GFDRLILLWNVYGDCDNYATLKG-HSGAVMELHY 117
Query: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNP-HHVDKLVTVGIKH 839
+ DG L S D ++ WD + GE++ +GH FV C P +LV G
Sbjct: 118 NTDGSMLFSASTDK--TVAVWDSETGERVKRLKGHTS--FVNSCYPARRGPQLVCTGSDD 173
Query: 840 --IKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDILL 895
+K W K+ + ++ V++ D + SG DI +W + L
Sbjct: 174 GTVKLWD------IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL 227
Query: 896 LKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD----DMFERCLKTYAIKRSALSTS 949
T++ H V + +G ++ D V +WD ERC+K + + +
Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF---QGNVHNF 284
Query: 950 SKGLL----LEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLA 1005
K LL D I A + + T + IL + GH G + +A
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL---------YKLPGH-AGSINEVA 334
Query: 1006 AHPLLPICATVSDDKTLRIWEL 1027
HP PI + S DK L + E+
Sbjct: 335 FHPDEPIIISASSDKRLYMGEI 356
Score = 58.2 bits (139), Expect = 8e-08
Identities = 71/351 (20%), Positives = 139/351 (39%), Gaps = 71/351 (20%)
Query: 94 NVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWD-WRKGKLLASATGHSDR 152
++Q +L H V C F +G LAS G D + +W+ + A+ GHS
Sbjct: 54 SLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFD--RLILLWNVYGDCDNYATLKGHSGA 111
Query: 153 IFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITY 212
+ ++ ++ + +
Sbjct: 112 VMELHYN----------------------------------------------TDGSMLF 125
Query: 213 SGALNGDIYVWKGL--NLVRTIQGAHSAGIFSMYACEEG---FATGGRDGCIRLWDTDFK 267
S + + + VW V+ ++G H++ + S Y G TG DG ++LWD
Sbjct: 126 SASTDKTVAVWDSETGERVKRLKG-HTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR-- 182
Query: 268 PITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGE 327
K ++ + Y+ L++ + +D++++G D++I +V ++K ++GH +
Sbjct: 183 --KKAAIQTFQNTYQVLAV-TFNDTSDQIISGGIDNDI-KVWDLRQNKLTYTMRGHAD-S 237
Query: 328 LWALALHPKKPLAVTGSDDRSVRLWSLADHALIARC---------NMEEAVRSVAFSPDG 378
+ L+L + ++ + D +VR+W + A RC N E+ + ++SPDG
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297
Query: 379 SQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSND 429
S++A G D V + + I+E+ F PD + S+D
Sbjct: 298 SKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 55.1 bits (131), Expect = 7e-07
Identities = 72/310 (23%), Positives = 120/310 (38%), Gaps = 33/310 (10%)
Query: 1497 AKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYK--KGVIGSLGAAK 1554
A + GH ++ +F P+ T + + + W + G Y KG G++
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
Query: 1555 MQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVA-KAHTGPVFTMYTTLRDGLIVTG 1613
T S+ F A+ + V VW R+ K HT V + Y R +V
Sbjct: 117 YNTDGSMLFSAST-------DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
Query: 1614 GKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRG--KGKILVGTKDGEIIEV 1671
G + G VKLWD K ++T Q V +V +I+ G D +I
Sbjct: 170 GSD-----DGTVKLWDIRKKAA----IQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 1672 GEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDL---ADKKLLNKVSLG 1728
+ + GH + + GL+ +S + D T R+WD+ A K+ K+ G
Sbjct: 221 DLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279
Query: 1729 HA-------ARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPD 1781
+ RC+ +SPDG +A G + + S ++ K +I ++ PD
Sbjct: 280 NVHNFEKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Query: 1782 NRFLAVGSSE 1791
+ SS+
Sbjct: 339 EPIIISASSD 348
Score = 50.8 bits (120), Expect = 1e-05
Identities = 66/308 (21%), Positives = 126/308 (40%), Gaps = 43/308 (13%)
Query: 814 GHKDKIFVVKCNPHHVDKLVTVGIKH-IKFWQQAGG--GFTSKRGTFGSVGKLETMMCVS 870
GH+ +++ K +P+ L + G I W G + + +G G+V +L
Sbjct: 64 GHEGEVYCCKFHPNG-STLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH------ 116
Query: 871 YGRMEDLVFSGAATGDIFIWKDIL--LLKTVKAHDGPVFAMYALDKG---FVTGGKDGIV 925
Y ++FS + + +W +K +K H V + Y +G TG DG V
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
Query: 926 ELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITLG--HGHILVGTKNGEILEI 983
+LWD K++A+ T ++ + A+T I+ G + +I
Sbjct: 177 KLWD----------IRKKAAIQT------FQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 984 D-KSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWEL---SAQHRMLA---- 1035
D + +T ++GH + V GL+ + + D T+R+W++ + + R +
Sbjct: 221 DLRQNKLTYTMRGHAD-SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279
Query: 1036 -VRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDT 1094
V +K C++SPDG +A G D V + + + I+++ F D
Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
Query: 1095 GKYLAVAS 1102
++ +S
Sbjct: 340 PIIISASS 347
Score = 47.8 bits (112), Expect = 1e-04
Identities = 56/248 (22%), Positives = 92/248 (37%), Gaps = 22/248 (8%)
Query: 251 ATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKAD-RLLAGTQDSEIFEVI 309
A+ G D I LW+ D T +G+ G ++ + + D +L + V
Sbjct: 82 ASAGFDRLILLWNV----YGDCDNYATLKGHSG-AVMELHYNTDGSMLFSASTDKTVAVW 136
Query: 310 VRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAV 369
E + + L+GH L TGSDD +V+LW + A I V
Sbjct: 137 DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQV 196
Query: 370 RSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSND 429
+V F+ Q+ G D V +R ++ + + + S +GSYL + D
Sbjct: 197 LAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Query: 430 GPVDV-----YAVAQRYKKI--GECSKSLSFITHIDWSLD---------SKYLQTNDGAG 473
V V +A +R KI G + WS D +++ D
Sbjct: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTS 316
Query: 474 ERLFYRMP 481
R+ Y++P
Sbjct: 317 RRILYKLP 324
Score = 39.3 bits (90), Expect = 0.038
Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 6/129 (4%)
Query: 316 PMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSL---ADHALIARCNMEEAVRSV 372
P+++L GH EGE++ HP + DR + LW++ D+ + AV +
Sbjct: 58 PIMLLSGH-EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK-GHSGAVMEL 115
Query: 373 AFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYL-AVGSNDGP 431
++ DGS L D + V V +K ++ + G L GS+DG
Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
Query: 432 VDVYAVAQR 440
V ++ + ++
Sbjct: 176 VKLWDIRKK 184
Score = 37.4 bits (85), Expect = 0.15
Identities = 47/229 (20%), Positives = 89/229 (38%), Gaps = 39/229 (17%)
Query: 1592 KAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEM-KRCRAFQLETGQLVECVR 1650
K H+G V ++ ++ + ++ V +WD E +R + + T + C
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDK------TVAVWDSETGERVKRLKGHTSFVNSCYP 159
Query: 1651 SVCRGKGKILVGTKDGEI-IEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDG 1709
+ RG + G+ DG + + K AA + + ++ + + + D IS D
Sbjct: 160 AR-RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY---QVLAVTFNDTSDQIISGGIDN 215
Query: 1710 TARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVI--LLVNSLKVW---- 1763
++WDL KL + GHA S E G +++ + N+++VW
Sbjct: 216 DIKVWDLRQNKLTYTMR-GHADSVTGLSLSSE--------GSYLLSNAMDNTVRVWDVRP 266
Query: 1764 ------------GKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
G + + + SPD +A GS++ V +D T
Sbjct: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Score = 37.4 bits (85), Expect = 0.15
Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 6/83 (7%)
Query: 75 LVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCI 134
LV TG + + +WD + ++ T+ V + F+ ++ S G+D N + +
Sbjct: 166 LVCTGS--DDGTVKLWDIRKKAAIQTFQN--TYQVLAVTFNDTSDQIISGGID--NDIKV 219
Query: 135 WDWRKGKLLASATGHSDRIFDIS 157
WD R+ KL + GH+D + +S
Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLS 242
Score = 34.3 bits (77), Expect = 1.2
Identities = 24/147 (16%), Positives = 61/147 (41%), Gaps = 7/147 (4%)
Query: 1701 LFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSL 1760
L + S+DGT ++WD+ K + + ++ + + G + + + +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 1761 KVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRI-----GYCKDIP 1815
K+ R ++ + +S + +L + ++TV +D+ R G +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 1816 SFVIQMDFSADGKYIQVSTGAYKRQVH 1842
+++ +S DG +++ G+ R V+
Sbjct: 286 KNLLRCSWSPDGS--KIAAGSADRFVY 310
Score = 31.6 bits (70), Expect = 8.0
Identities = 26/126 (20%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 46 VYNTREHSQKFFL-GHNDDIISLALHPDKTLVATGQVGKEPYICIWD----SYNVQTVSL 100
V++ R++ + + GH D + L+L + + + + + + +WD + + V +
Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNT--VRVWDVRPFAPKERCVKI 276
Query: 101 LK-DVHTHGVACL--AFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDIS 157
+ +VH L ++ DG ++A+ D V +WD ++L GH+ I +++
Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSAD--RFVYVWDTTSRRILYKLPGHAGSINEVA 334
Query: 158 WDPYQP 163
+ P +P
Sbjct: 335 FHPDEP 340
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 64.7 bits (156), Expect = 8e-10
Identities = 78/314 (24%), Positives = 128/314 (40%), Gaps = 37/314 (11%)
Query: 724 LGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSAD 783
+GH + + S+ P +++A+ D I +W K L G H + + +S+D
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSA--DRLIIIWGAYDGKYEKTLYG-HNLEISDVAWSSD 94
Query: 784 GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI--KHIK 841
LVS D ++ WD + G+ + T +GH + +F CN + L+ G + +K
Sbjct: 95 SSRLVSAS--DDKTLKLWDVRSGKCLKTLKGHSNYVFC--CNFNPPSNLIISGSFDETVK 150
Query: 842 FWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDI--LLLKTV 899
W+ G + + V + L+ SG+ G IW LKT+
Sbjct: 151 IWEVKTGKCLKTLSAHS-----DPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 900 KAHDGPVFAMYALD---KGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLE 956
D P + K +T D ++LWD RCLKTY ++ +
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT------GHKNEKYCIF 259
Query: 957 DNPSI---RAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPL--LP 1011
N S+ + I G LV N + EI + +QGH + V A HP L
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK------LQGHTD-VVISAACHPTENLI 312
Query: 1012 ICATVSDDKTLRIW 1025
A + +DKT+++W
Sbjct: 313 ASAALENDKTIKLW 326
Score = 58.9 bits (141), Expect = 5e-08
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 36/310 (11%)
Query: 58 LGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSD 117
+GH + + S+ P+ +A+ + I IW +Y+ + L H ++ +A+ SD
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSADR--LIIIWGAYDGKYEKTLYG-HNLEISDVAWSSD 94
Query: 118 GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGV--KHIK 175
RL S D T+ +WD R GK L + GHS+ +F +++P P+ ++ G + +K
Sbjct: 95 SSRLVSASDD--KTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP--PSNLIISGSFDETVK 150
Query: 176 FWTL----CGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLN--LV 229
W + C L+A D + + C+ + SG+ +G +W + +
Sbjct: 151 IWEVKTGKCLKTLSAH-------SDPVSAVHFNCS-GSLIVSGSYDGLCRIWDAASGQCL 202
Query: 230 RTIQGAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGY---KGL 284
+T+ + + + G T D ++LWD K + Y
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 285 SIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGS 344
S+ W +++G++D+ ++ + + + + LQGH + + A A HP + L + +
Sbjct: 263 SVTGGKW----IVSGSEDNLVY-IWNLQTKEIVQKLQGHTDVVISA-ACHPTENLIASAA 316
Query: 345 --DDRSVRLW 352
+D++++LW
Sbjct: 317 LENDKTIKLW 326
Score = 47.4 bits (111), Expect = 1e-04
Identities = 43/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 284 LSIRSVCWKAD--RLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAV 341
L I V W +D RL++ + D + VR K + L+GH ++ +P L +
Sbjct: 84 LEISDVAWSSDSSRLVSASDDKTLKLWDVRS-GKCLKTLKGH-SNYVFCCNFNPPSNLII 141
Query: 342 TGSDDRSVRLWSLADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTE 400
+GS D +V++W + + + + V +V F+ GS + G DG + R+ D
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG---LCRIWDAAS 198
Query: 401 VVHIK----DRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKS 450
+K D + +KFSP+G Y+ + D + ++ ++ G C K+
Sbjct: 199 GQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR-----GRCLKT 247
Score = 41.2 bits (95), Expect = 0.010
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 29/264 (10%)
Query: 1461 HSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDT 1520
H+ ++ + +S+ LVS D T+ +W + G + + GH +F F P S+
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDK--TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNL 139
Query: 1521 QFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFG-ANNLTFTGAINGDVY 1579
+ +K W + K G +A + +V F + +L +G+ +G
Sbjct: 140 IISGSFDETVKIWEV-------KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 1580 VW--KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRA 1637
+W ++ + PV + + I+T + +KLWD RC
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD------NTLKLWDYSRGRC-- 244
Query: 1638 FQLETGQLVE--CV---RSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWG 1692
+ TG E C+ SV GK I+ G++D + + + GH + I
Sbjct: 245 LKTYTGHKNEKYCIFANFSVTGGKW-IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI-S 302
Query: 1693 LATHPSKDLFISAS--NDGTARIW 1714
A HP+++L SA+ ND T ++W
Sbjct: 303 AACHPTENLIASAALENDKTIKLW 326
Score = 38.9 bits (89), Expect = 0.050
Identities = 37/149 (24%), Positives = 60/149 (40%), Gaps = 7/149 (4%)
Query: 1689 EIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHA--ARCAAYSPDGEMVAIG 1746
EI +A +SAS+D T ++WD+ K L K GH+ C ++P ++ G
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCL-KTLKGHSNYVFCCNFNPPSNLIISG 143
Query: 1747 MKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLN 1806
+ I V + K + + + + GS + +D G L
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 1807 RIGYCKDIP-SFVIQMDFSADGKYIQVST 1834
+ + P SFV FS +GKYI +T
Sbjct: 204 TLVDDDNPPVSFV---KFSPNGKYILTAT 229
Score = 38.1 bits (87), Expect = 0.085
Identities = 36/187 (19%), Positives = 77/187 (41%), Gaps = 16/187 (8%)
Query: 944 SALSTSSKGLLLEDNPSIRAITLGHGHILVGTK---NGEILEIDKSGPMTLLVQGHMEG- 999
S+ + SK + N +++ +GH + K NGE L S +++ G +G
Sbjct: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLA-SSSADRLIIIWGAYDGK 74
Query: 1000 ----------EVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFS 1049
E+ +A + SDDKTL++W++ + + ++ CC F+
Sbjct: 75 YEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN 134
Query: 1050 PDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDI 1109
P + G D + + T + + + + +S + F+ +G + S+D I
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN-CSGSLIVSGSYDGLCRI 193
Query: 1110 YNVLTSK 1116
++ + +
Sbjct: 194 WDAASGQ 200
Score = 37.0 bits (84), Expect = 0.19
Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 10/119 (8%)
Query: 336 KKPLAVTGSDDRSVRLWSLADHALIARCNM---EEAVRSVAFSPDGSQLALGMKDGSFIV 392
K LA++ S ++S + ++AL +C + EAV SV FSP+G LA D I+
Sbjct: 10 KAQLALSSSANQSKEVPENPNYAL--KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
Query: 393 LRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSL 451
D + I ++ +S D S L S+D + ++ V + G+C K+L
Sbjct: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV-----RSGKCLKTL 121
Score = 33.5 bits (75), Expect = 2.1
Identities = 31/147 (21%), Positives = 52/147 (35%), Gaps = 12/147 (8%)
Query: 1625 VKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDG 1684
+KLWD +C V C +++ E +++ E +
Sbjct: 107 LKLWDVRSGKCLKTLKGHSNYVFCCNF--NPPSNLIISGSFDETVKIWEVKTGKCLKTLS 164
Query: 1685 HMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV--SLGHAARCAAYSPDGEM 1742
+ + + S L +S S DG RIWD A + L + +SP+G+
Sbjct: 165 AHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKY 224
Query: 1743 VAIGMKNGEFVILLVNSLKVWGKKRDR 1769
+ L N+LK+W R R
Sbjct: 225 I--------LTATLDNTLKLWDYSRGR 243
Score = 33.5 bits (75), Expect = 2.1
Identities = 17/61 (27%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 1445 IWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGG 1504
IWDA + L L + V+++ FS GK +++ +D +T+ +W + G + + G
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD--NTLKLWDYSRGRCLKTYTG 250
Query: 1505 H 1505
H
Sbjct: 251 H 251
Score = 33.1 bits (74), Expect = 2.7
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 15/85 (17%)
Query: 19 YRGHQCRN-----NLYYTAGKEVVYFVAGV--GVVY----NTREHSQKFFLGHNDDIISL 67
Y GH+ N T GK + V+G +VY T+E QK GH D +IS
Sbjct: 248 YTGHKNEKYCIFANFSVTGGK---WIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVISA 303
Query: 68 ALHPDKTLVATGQVGKEPYICIWDS 92
A HP + L+A+ + + I +W S
Sbjct: 304 ACHPTENLIASAALENDKTIKLWMS 328
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 63.5 bits (153), Expect = 2e-09
Identities = 75/314 (23%), Positives = 126/314 (40%), Gaps = 37/314 (11%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADG 784
GH + S+ P +++A+ D I +W K + G H+ G+ + +S+D
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSA--DKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDS 99
Query: 785 KCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI--KHIKF 842
LVS D ++ WD G+ + T +GH + +F NP L+ G + ++
Sbjct: 100 NLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ--SNLIVSGSFDESVRI 155
Query: 843 WQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDI--LLLKTVK 900
W G + + V + R L+ S + G IW LKT+
Sbjct: 156 WDVKTGKCLKTLPAHS-----DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 901 AHDGPVFAMYALD---KGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLED 957
D P + K + D ++LWD +CLKTY ++ +
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT------GHKNEKYCIFA 264
Query: 958 NPSI---RAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICA 1014
N S+ + I G LV N + EI + +QGH + V A HP I A
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK------LQGHTD-VVISTACHPTENIIA 317
Query: 1015 T--VSDDKTLRIWE 1026
+ + +DKT+++W+
Sbjct: 318 SAALENDKTIKLWK 331
Score = 56.6 bits (135), Expect = 2e-07
Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 248 EGFATGGRDGCIRLWDT-DFKPITKIDLRETEQGYKGLSIRSVCWKAD-RLLAGTQDSEI 305
E A+ D I++W D K +T G+K L I V W +D LL D +
Sbjct: 58 EWLASSSADKLIKIWGAYDGK------FEKTISGHK-LGISDVAWSSDSNLLVSASDDKT 110
Query: 306 FEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSL-ADHALIARCN 364
++ K + L+GH ++ +P+ L V+GS D SVR+W + L
Sbjct: 111 LKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 365 MEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIK----DRKEVIHEMKFSPDG 420
+ V +V F+ DGS + DG + R+ D +K D + +KFSP+G
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG 226
Query: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKS 450
Y+ + D + ++ ++ G+C K+
Sbjct: 227 KYILAATLDNTLKLWDYSK-----GKCLKT 251
Score = 50.8 bits (120), Expect = 1e-05
Identities = 70/321 (21%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 52 HSQKFFL-GHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVA 110
++ KF L GH + S+ P+ +A+ K I IW +Y+ + + H G++
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADK--LIKIWGAYDGKFEKTISG-HKLGIS 91
Query: 111 CLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCG 170
+A+ SD L S D T+ IWD GK L + GHS+ +F +++P Q N +VS
Sbjct: 92 DVAWSSDSNLLVSASDD--KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGS 148
Query: 171 V-KHIKFW---------TLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDI 220
+ ++ W TL ++ F + G L S + +G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL-------------IVSSSYDGLC 195
Query: 221 YVW---KGLNLVRTIQGAHSAGIFSMYACEEGFATGGR-DGCIRLWDTDFKPITKIDLRE 276
+W G L I + F ++ + D ++LWD K
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 277 TEQGY---KGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALAL 333
+ Y S+ W +++G++D+ ++ + + + + LQGH + + + A
Sbjct: 256 KNEKYCIFANFSVTGGKW----IVSGSEDNLVY-IWNLQTKEIVQKLQGHTDVVI-STAC 309
Query: 334 HPKKPLAVTGS--DDRSVRLW 352
HP + + + + +D++++LW
Sbjct: 310 HPTENIIASAALENDKTIKLW 330
Score = 49.7 bits (117), Expect = 3e-05
Identities = 66/285 (23%), Positives = 108/285 (37%), Gaps = 44/285 (15%)
Query: 1461 HSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDT 1520
H+K V+ + FS G+ L S D I +W +G + GH I V + DS+
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADK--LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 1521 QFVSVGVKHMKFWTL-AGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVY 1579
+ K +K W + +G L KG + +NL +G+ + V
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-------SNLIVSGSFDESVR 154
Query: 1580 VW--KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRC-R 1636
+W K ++ + AH+ PV ++ LIV+ + G ++WD +C +
Sbjct: 155 IWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYD------GLCRIWDTASGQCLK 207
Query: 1637 AFQLETGQLVECVRSVCRGKGKILVGTKDGEI------------IEVGEKNAASNILIDG 1684
+ V V+ GK IL T D + G KN I +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 1685 HMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGH 1729
+ G W +S S D IW+L K+++ K+ GH
Sbjct: 267 SVTGGKW----------IVSGSEDNLVYIWNLQTKEIVQKLQ-GH 300
Score = 48.9 bits (115), Expect = 5e-05
Identities = 43/187 (22%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 944 SALSTSSKGLLLEDNPSIRAITLGHGHILVGTK---NGEIL---EIDK--------SGPM 989
S+ +T SK ++ N +++ GH + K NGE L DK G
Sbjct: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79
Query: 990 TLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFS 1049
+ GH G + +A + + SDDKTL+IW++S+ + ++ CC F+
Sbjct: 80 EKTISGHKLG-ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 1050 PDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDI 1109
P + G D S + + T + + + + +S + F++D G + +S+D I
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRI 197
Query: 1110 YNVLTSK 1116
++ + +
Sbjct: 198 WDTASGQ 204
Score = 48.9 bits (115), Expect = 5e-05
Identities = 45/172 (26%), Positives = 80/172 (46%), Gaps = 17/172 (9%)
Query: 60 HNDDIISLALHPDKTLVATGQVGKEPYIC-IWDSYNVQTVSLLKDVHTHGVACLAFDSDG 118
H+D + ++ + D +L+ + +C IWD+ + Q + L D V+ + F +G
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG 226
Query: 119 QRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDI--SWDPYQPNRVVSCGVKHIKF 176
+ + + LD NT+ +WD+ KGK L + TGH + + I ++ +VS ++ +
Sbjct: 227 KYILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 177 -WTLCGNALTAKRGIFGKTGDLQTILCLAC-AKEDITYSGALNGD--IYVWK 224
W L + K G ++ AC E+I S AL D I +WK
Sbjct: 285 IWNLQTKEIVQK-----LQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 45.8 bits (107), Expect = 4e-04
Identities = 54/225 (24%), Positives = 91/225 (40%), Gaps = 10/225 (4%)
Query: 1615 KERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSV-CRGKGKILVGTKDGEIIEV-G 1672
+ +PT A + +K A + + V SV G+ L + ++I++ G
Sbjct: 14 RAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG 73
Query: 1673 EKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHA-- 1730
+ I GH G I +A +L +SAS+D T +IWD++ K L K GH+
Sbjct: 74 AYDGKFEKTISGHKLG-ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNY 131
Query: 1731 ARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSS 1790
C ++P ++ G + I V + K + + + D + S
Sbjct: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 1791 EHTVDFYDLTQGTNLNRIGYCKDIP-SFVIQMDFSADGKYIQVST 1834
+ +D G L + + P SFV FS +GKYI +T
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFV---KFSPNGKYILAAT 233
Score = 33.5 bits (75), Expect = 2.1
Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 32/161 (19%)
Query: 409 EVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLS----FITHIDWSLDSK 464
+ + +KFSP+G +LA S D + ++ G+ K++S I+ + WS DS
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGISDVAWSSDSN 100
Query: 465 YLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPE----VSGIWPKYTEVTD 520
L + + + SGK L + +KG + C P+ VSG + + + D
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 521 ----------------INSVDANYNSSVLVSGDDFGLVKLF 545
+++V N + S++VS GL +++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 33.5 bits (75), Expect = 2.1
Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 26/179 (14%)
Query: 1413 HTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSA 1472
H+D + + N+ +V++S G IWD + L L + V+++ FS
Sbjct: 170 HSDPVSAVHFNRDGSL--IVSSSYDGLC---RIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 1473 TGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKF 1532
GK +++ +D +T+ +W + +G + + GH + + F + V K
Sbjct: 225 NGKYILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCI---------FANFSVTGGK- 272
Query: 1533 WTLAGSA--LLY-----KKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGD--VYVWK 1582
W ++GS L+Y K ++ L + + N+ + A+ D + +WK
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 33.1 bits (74), Expect = 2.7
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 15/85 (17%)
Query: 19 YRGHQCRN-----NLYYTAGKEVVYFVAGV--GVVY----NTREHSQKFFLGHNDDIISL 67
Y GH+ N T GK + V+G +VY T+E QK GH D +IS
Sbjct: 252 YTGHKNEKYCIFANFSVTGGK---WIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVIST 307
Query: 68 ALHPDKTLVATGQVGKEPYICIWDS 92
A HP + ++A+ + + I +W S
Sbjct: 308 ACHPTENIIASAALENDKTIKLWKS 332
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 63.5 bits (153), Expect = 2e-09
Identities = 75/314 (23%), Positives = 126/314 (40%), Gaps = 37/314 (11%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADG 784
GH + S+ P +++A+ D I +W K + G H+ G+ + +S+D
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSA--DKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDS 99
Query: 785 KCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI--KHIKF 842
LVS D ++ WD G+ + T +GH + +F NP L+ G + ++
Sbjct: 100 NLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ--SNLIVSGSFDESVRI 155
Query: 843 WQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDI--LLLKTVK 900
W G + + V + R L+ S + G IW LKT+
Sbjct: 156 WDVKTGKCLKTLPAHS-----DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 901 AHDGPVFAMYALD---KGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLED 957
D P + K + D ++LWD +CLKTY ++ +
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT------GHKNEKYCIFA 264
Query: 958 NPSI---RAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICA 1014
N S+ + I G LV N + EI + +QGH + V A HP I A
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK------LQGHTD-VVISTACHPTENIIA 317
Query: 1015 T--VSDDKTLRIWE 1026
+ + +DKT+++W+
Sbjct: 318 SAALENDKTIKLWK 331
Score = 56.6 bits (135), Expect = 2e-07
Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 248 EGFATGGRDGCIRLWDT-DFKPITKIDLRETEQGYKGLSIRSVCWKAD-RLLAGTQDSEI 305
E A+ D I++W D K +T G+K L I V W +D LL D +
Sbjct: 58 EWLASSSADKLIKIWGAYDGK------FEKTISGHK-LGISDVAWSSDSNLLVSASDDKT 110
Query: 306 FEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSL-ADHALIARCN 364
++ K + L+GH ++ +P+ L V+GS D SVR+W + L
Sbjct: 111 LKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 365 MEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIK----DRKEVIHEMKFSPDG 420
+ V +V F+ DGS + DG + R+ D +K D + +KFSP+G
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG 226
Query: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKS 450
Y+ + D + ++ ++ G+C K+
Sbjct: 227 KYILAATLDNTLKLWDYSK-----GKCLKT 251
Score = 50.8 bits (120), Expect = 1e-05
Identities = 70/321 (21%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 52 HSQKFFL-GHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVA 110
++ KF L GH + S+ P+ +A+ K I IW +Y+ + + H G++
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADK--LIKIWGAYDGKFEKTISG-HKLGIS 91
Query: 111 CLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCG 170
+A+ SD L S D T+ IWD GK L + GHS+ +F +++P Q N +VS
Sbjct: 92 DVAWSSDSNLLVSASDD--KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGS 148
Query: 171 V-KHIKFW---------TLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDI 220
+ ++ W TL ++ F + G L S + +G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL-------------IVSSSYDGLC 195
Query: 221 YVW---KGLNLVRTIQGAHSAGIFSMYACEEGFATGGR-DGCIRLWDTDFKPITKIDLRE 276
+W G L I + F ++ + D ++LWD K
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 277 TEQGY---KGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALAL 333
+ Y S+ W +++G++D+ ++ + + + + LQGH + + + A
Sbjct: 256 KNEKYCIFANFSVTGGKW----IVSGSEDNLVY-IWNLQTKEIVQKLQGHTDVVI-STAC 309
Query: 334 HPKKPLAVTGS--DDRSVRLW 352
HP + + + + +D++++LW
Sbjct: 310 HPTENIIASAALENDKTIKLW 330
Score = 49.7 bits (117), Expect = 3e-05
Identities = 66/285 (23%), Positives = 108/285 (37%), Gaps = 44/285 (15%)
Query: 1461 HSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDT 1520
H+K V+ + FS G+ L S D I +W +G + GH I V + DS+
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADK--LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 1521 QFVSVGVKHMKFWTL-AGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVY 1579
+ K +K W + +G L KG + +NL +G+ + V
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-------SNLIVSGSFDESVR 154
Query: 1580 VW--KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRC-R 1636
+W K ++ + AH+ PV ++ LIV+ + G ++WD +C +
Sbjct: 155 IWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYD------GLCRIWDTASGQCLK 207
Query: 1637 AFQLETGQLVECVRSVCRGKGKILVGTKDGEI------------IEVGEKNAASNILIDG 1684
+ V V+ GK IL T D + G KN I +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 1685 HMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGH 1729
+ G W +S S D IW+L K+++ K+ GH
Sbjct: 267 SVTGGKW----------IVSGSEDNLVYIWNLQTKEIVQKLQ-GH 300
Score = 48.9 bits (115), Expect = 5e-05
Identities = 43/187 (22%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 944 SALSTSSKGLLLEDNPSIRAITLGHGHILVGTK---NGEIL---EIDK--------SGPM 989
S+ +T SK ++ N +++ GH + K NGE L DK G
Sbjct: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79
Query: 990 TLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFS 1049
+ GH G + +A + + SDDKTL+IW++S+ + ++ CC F+
Sbjct: 80 EKTISGHKLG-ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 1050 PDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDI 1109
P + G D S + + T + + + + +S + F++D G + +S+D I
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRI 197
Query: 1110 YNVLTSK 1116
++ + +
Sbjct: 198 WDTASGQ 204
Score = 48.9 bits (115), Expect = 5e-05
Identities = 45/172 (26%), Positives = 80/172 (46%), Gaps = 17/172 (9%)
Query: 60 HNDDIISLALHPDKTLVATGQVGKEPYIC-IWDSYNVQTVSLLKDVHTHGVACLAFDSDG 118
H+D + ++ + D +L+ + +C IWD+ + Q + L D V+ + F +G
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG 226
Query: 119 QRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDI--SWDPYQPNRVVSCGVKHIKF 176
+ + + LD NT+ +WD+ KGK L + TGH + + I ++ +VS ++ +
Sbjct: 227 KYILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 177 -WTLCGNALTAKRGIFGKTGDLQTILCLAC-AKEDITYSGALNGD--IYVWK 224
W L + K G ++ AC E+I S AL D I +WK
Sbjct: 285 IWNLQTKEIVQK-----LQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 45.8 bits (107), Expect = 4e-04
Identities = 54/225 (24%), Positives = 91/225 (40%), Gaps = 10/225 (4%)
Query: 1615 KERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSV-CRGKGKILVGTKDGEIIEV-G 1672
+ +PT A + +K A + + V SV G+ L + ++I++ G
Sbjct: 14 RAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG 73
Query: 1673 EKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHA-- 1730
+ I GH G I +A +L +SAS+D T +IWD++ K L K GH+
Sbjct: 74 AYDGKFEKTISGHKLG-ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNY 131
Query: 1731 ARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSS 1790
C ++P ++ G + I V + K + + + D + S
Sbjct: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 1791 EHTVDFYDLTQGTNLNRIGYCKDIP-SFVIQMDFSADGKYIQVST 1834
+ +D G L + + P SFV FS +GKYI +T
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFV---KFSPNGKYILAAT 233
Score = 33.5 bits (75), Expect = 2.1
Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 32/161 (19%)
Query: 409 EVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLS----FITHIDWSLDSK 464
+ + +KFSP+G +LA S D + ++ G+ K++S I+ + WS DS
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGISDVAWSSDSN 100
Query: 465 YLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPE----VSGIWPKYTEVTD 520
L + + + SGK L + +KG + C P+ VSG + + + D
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 521 ----------------INSVDANYNSSVLVSGDDFGLVKLF 545
+++V N + S++VS GL +++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 33.5 bits (75), Expect = 2.1
Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 26/179 (14%)
Query: 1413 HTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSA 1472
H+D + + N+ +V++S G IWD + L L + V+++ FS
Sbjct: 170 HSDPVSAVHFNRDGSL--IVSSSYDGLC---RIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 1473 TGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKF 1532
GK +++ +D +T+ +W + +G + + GH + + F + V K
Sbjct: 225 NGKYILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCI---------FANFSVTGGK- 272
Query: 1533 WTLAGSA--LLY-----KKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGD--VYVWK 1582
W ++GS L+Y K ++ L + + N+ + A+ D + +WK
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 33.1 bits (74), Expect = 2.7
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 15/85 (17%)
Query: 19 YRGHQCRN-----NLYYTAGKEVVYFVAGV--GVVY----NTREHSQKFFLGHNDDIISL 67
Y GH+ N T GK + V+G +VY T+E QK GH D +IS
Sbjct: 252 YTGHKNEKYCIFANFSVTGGK---WIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVIST 307
Query: 68 ALHPDKTLVATGQVGKEPYICIWDS 92
A HP + ++A+ + + I +W S
Sbjct: 308 ACHPTENIIASAALENDKTIKLWKS 332
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 62.4 bits (150), Expect = 4e-09
Identities = 76/325 (23%), Positives = 130/325 (40%), Gaps = 59/325 (18%)
Query: 148 GHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTIL--CLAC 205
GH +F +W+P G + W L N+ + G Q +L C+
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTS---------GSTQLVLRHCIRE 217
Query: 206 AKEDITYS-----------------GALNGDIYVW-KGLNLVRTIQGAHSAGIFSMYACE 247
+D+ + G+ +G +W K NL T+ G H IF++ +
Sbjct: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTL-GQHKGPIFALKWNK 276
Query: 248 EG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRS--VCWKADRLLAGTQDS 303
+G + G D +WD E +Q + S + V W+++ A
Sbjct: 277 KGNFILSAGVDKTTIIWDAH--------TGEAKQQFPFHSAPALDVDWQSNNTFASCSTD 328
Query: 304 EIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLAD----HAL 359
V +D+P+ QGH E+ A+ P L + SDD ++++WS+ H L
Sbjct: 329 MCIHVCKLGQDRPIKTFQGHTN-EVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL 387
Query: 360 IARCNMEEAVRSVAFSPDGS-----QLALGMKDGSF-IVLRVRDMTEVVHIKD---RKEV 410
A + + ++ +SP G L + SF +R+ D+ + I +E
Sbjct: 388 QAH---NKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEP 444
Query: 411 IHEMKFSPDGSYLAVGSNDGPVDVY 435
++ + FSPDG YLA GS D V ++
Sbjct: 445 VYSVAFSPDGRYLASGSFDKCVHIW 469
Score = 55.5 bits (132), Expect = 5e-07
Identities = 86/360 (23%), Positives = 137/360 (38%), Gaps = 55/360 (15%)
Query: 808 KIATTRGHKDKIFVVKCNPHHVDKLVTVGI--KHIKFWQQAGGGFTSKRGTFGSVGKLET 865
K RGH+ ++F+ NP V L+ G + W S+ T GS +L
Sbjct: 161 KAVVLRGHESEVFICAWNP--VSDLLASGSGDSTARIWN------LSENSTSGST-QLVL 211
Query: 866 MMCVSYGRME----------------DLVFSGAATGDIFIW-KDILLLKTVKAHDGPVFA 908
C+ G + L+ +G+ G IW KD L T+ H GP+FA
Sbjct: 212 RHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFA 271
Query: 909 MYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITL 966
+ KG ++ G D +WD T K+ S+ L ++ + +
Sbjct: 272 LKWNKKGNFILSAGVDKTTIIWD------AHTGEAKQQFPFHSAPALDVDWQSNNTFASC 325
Query: 967 GHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWE 1026
+ K G+ I QGH EV + P + A+ SDD TL+IW
Sbjct: 326 STDMCIHVCKLGQDRPIKT-------FQGHTN-EVNAIKWDPTGNLLASCSDDMTLKIWS 377
Query: 1027 LSAQHRMLAVRKLKKGGRCCAFSPDGKA---------LAVGLNDGSFLVVNADTVEDMVS 1077
+ + + ++ K +SP G LA D + + + D + +
Sbjct: 378 MKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHT 437
Query: 1078 FHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRG 1137
+E + + FS D G+YLA S D V I+N T V +G I + W++ G
Sbjct: 438 LTKHQEPVYSVAFSPD-GRYLASGSFDKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAG 495
Score = 48.1 bits (113), Expect = 8e-05
Identities = 76/353 (21%), Positives = 120/353 (33%), Gaps = 81/353 (22%)
Query: 61 NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR 120
N D+ SL + + TL+ATG I D T+ H + L ++ G
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQ----HKGPIFALKWNKKGNF 280
Query: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC 180
+ S G+D T IWD G+ HS D+ W N SC
Sbjct: 281 ILSAGVD--KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--SNNTFASCSTDMCIHVCKL 336
Query: 181 GNALTAKRGIFGKTGDLQTIL------CLACAKEDITYSGALNGDIYVWKGLNLVRTIQG 234
G K G T ++ I LA +D+T I+ K N V +Q
Sbjct: 337 GQDRPIKT-FQGHTNEVNAIKWDPTGNLLASCSDDMTLK------IWSMKQDNCVHDLQ- 388
Query: 235 AHSAGIFSMYACEEG-----------FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKG 283
AH+ I+++ G A+ D +RLWD D +G
Sbjct: 389 AHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD----------------RG 432
Query: 284 LSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTG 343
+ I ++ T+ E ++++A P +G
Sbjct: 433 ICIHTL----------TKHQE----------------------PVYSVAFSPDGRYLASG 460
Query: 344 SDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVR 396
S D+ V +W+ AL+ + V ++ G ++ DGS VL +R
Sbjct: 461 SFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 46.6 bits (109), Expect = 2e-04
Identities = 64/333 (19%), Positives = 118/333 (35%), Gaps = 59/333 (17%)
Query: 1504 GHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA-----GSALLYKKGVI--GSLGAAKMQ 1556
GH +F+ + P SD G + W L+ GS L + I G +
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNK 226
Query: 1557 TMLSVAFGANN-LTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGK 1615
+ S+ + + L TG+ +G +W + H GP+F + + I++ G
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 1616 ERPTKEGGAVKLWDQ---EMKRCRAFQ---------LETGQLVECVRSVCRGKGKILVGT 1663
++ T +WD E K+ F C +C
Sbjct: 287 DKTT------IIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCI--------- 331
Query: 1664 KDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLN 1723
+ ++G+ GH E+ + P+ +L S S+D T +IW + ++
Sbjct: 332 ---HVCKLGQDRPIKT--FQGH-TNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVH 385
Query: 1724 KVSL-GHAARCAAYSPDGEMVAIGMKNGEFVILLV-----NSLKVWGKKR--------DR 1769
+ +SP G G N ++L +++++W R
Sbjct: 386 DLQAHNKEIYTIKWSPTGP----GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH 441
Query: 1770 KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQG 1802
+ + + SPD R+LA GS + V ++ G
Sbjct: 442 QEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTG 474
Score = 39.3 bits (90), Expect = 0.038
Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 20/115 (17%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWD---------TQTLKCLSLLKG----QH 771
GH+ ++ +PV D +A+G D+ +W+ TQ + + +G
Sbjct: 167 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 772 QRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRG-HKDKIFVVKCN 825
+ V +LD++++G L + D F I W K +A+T G HK IF +K N
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARI----WTKDGNLASTLGQHKGPIFALKWN 275
Score = 38.1 bits (87), Expect = 0.085
Identities = 66/321 (20%), Positives = 115/321 (35%), Gaps = 59/321 (18%)
Query: 1680 ILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKL--LNKVSLGHAARCAAYS 1737
+++ GH E E++ A +P DL S S D TARIW+L++ ++ L H R
Sbjct: 163 VVLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQD 221
Query: 1738 -PDGEMVAIGMKNGEFVILLVNS----LKVWGKKRD-------RKSAIQDIRISPDNRFL 1785
P + V N E +L S ++W K + K I ++ + F+
Sbjct: 222 VPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFI 281
Query: 1786 AVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVP 1845
+ T +D G + + P+ + +D+ ++ + ST +H
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPF-HSAPA--LDVDWQSNNTFASCSTDMC---IHVCK 335
Query: 1846 LGKQ------VTEAVVIEKITWASWTSVLG----DEVIGIWPRNADKADVNCACVT---- 1891
LG+ + I W ++L D + IW D +
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
Query: 1892 --------------HAGLNIVTGDDFGLVKLFDFP---CTEKFAKHKRYFGHSAHVTNIR 1934
+A L + + V+L+D C KH+ V ++
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE------PVYSVA 449
Query: 1935 FSYDDKYVVSTGGDDCSVFVW 1955
FS D +Y+ S D C V +W
Sbjct: 450 FSPDGRYLASGSFDKC-VHIW 469
Score = 35.4 bits (80), Expect = 0.55
Identities = 49/230 (21%), Positives = 96/230 (41%), Gaps = 31/230 (13%)
Query: 968 HGHILVGTKNGEILEIDKSGPM----TLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLR 1023
+G + + +++E+D + ++++GH E EV+ A +P+ + A+ S D T R
Sbjct: 136 NGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGH-ESEVFICAWNPVSDLLASGSGDSTAR 194
Query: 1024 IWEL-----SAQHRMLAVRKLKKGGR---------CCAFSPDGKALAVGLNDGSFLVVNA 1069
IW L S +++ +++GG+ ++ +G LA G DG +
Sbjct: 195 IWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK 254
Query: 1070 D-TVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYI 1128
D + + H K I +K++K G ++ A D I++ T + S+
Sbjct: 255 DGNLASTLGQH--KGPIFALKWNK-KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 311
Query: 1129 THIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIR-----PSEIEKIEWD 1173
+DW S S + + G+ I+ +E+ I+WD
Sbjct: 312 LDVDWQSNNTFA---SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWD 358
Score = 34.3 bits (77), Expect = 1.2
Identities = 36/177 (20%), Positives = 70/177 (39%), Gaps = 20/177 (11%)
Query: 692 NNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDA 751
NN F + + ++ H+ + Q + + GH +++ ++ P + +A+ D
Sbjct: 319 NNTFASCSTDMCIHVCKLG-----QDRPIKTFQGHTNEVNAIKWDPTGNLLAS--CSDDM 371
Query: 752 AIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGK---------CLVSVGLDDFHSIVFWD 802
+ +W + C+ L+ H + + + +S G L S D ++ WD
Sbjct: 372 TLKIWSMKQDNCVHDLQA-HNKEIYTIKWSPTGPGTNNPNANLMLASASFDS--TVRLWD 428
Query: 803 WKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQ-QAGGGFTSKRGTFG 858
+G I T H++ ++ V +P K + W Q G S RGT G
Sbjct: 429 VDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG 485
Score = 32.3 bits (72), Expect = 4.7
Identities = 38/179 (21%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 26 NNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEP 85
NN + + ++ V +G ++ K F GH +++ ++ P L+A+ +
Sbjct: 319 NNTFASCSTDMCIHVCKLG-----QDRPIKTFQGHTNEVNAIKWDPTGNLLAS--CSDDM 371
Query: 86 YICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQ---------RLASVGLDAKNTVCIWD 136
+ IW V L+ H + + + G LAS D+ TV +WD
Sbjct: 372 TLKIWSMKQDNCVHDLQ-AHNKEIYTIKWSPTGPGTNNPNANLMLASASFDS--TVRLWD 428
Query: 137 WRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGV--KHIKFW-TLCGNALTAKRGIFG 192
+G + + T H + ++ +++ P R ++ G K + W T G + + RG G
Sbjct: 429 VDRGICIHTLTKHQEPVYSVAFSP--DGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG 485
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 62.0 bits (149), Expect = 6e-09
Identities = 79/301 (26%), Positives = 124/301 (41%), Gaps = 64/301 (21%)
Query: 57 FLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDS 116
F GH +I+ L+ +P TLVATG + + +WD N + V L+ H+ + L+F++
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSM--DTTAKLWDIQNGEEVYTLRG-HSAEIISLSFNT 229
Query: 117 DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDIS--WDPYQPNRVVSCGVKHI 174
G R+ + D +TV +WD G+ + GH I S WD
Sbjct: 230 SGDRIITGSFD--HTVVVWDADTGRKVNILIGHCAEISSASFNWD--------------- 272
Query: 175 KFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQG 234
C LT G KT C D T NG V T+ G
Sbjct: 273 -----CSLILT---GSMDKT----------CKLWDAT-----NG--------KCVATLTG 301
Query: 235 AHSAGIFSMYACEEG--FATGGRDGCIRLWD-TDFKPITKIDLRETEQGYKGLSIRSVCW 291
H I G AT DG R++ K I K++ E E +S S
Sbjct: 302 -HDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE-----ISKISFNP 355
Query: 292 KADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRL 351
+ + LL G+ D + + + + + +L+GH + E+++ A + K + +TGS D + R+
Sbjct: 356 QGNHLLTGSSD-KTARIWDAQTGQCLQVLEGHTD-EIFSCAFNYKGNIVITGSKDNTCRI 413
Query: 352 W 352
W
Sbjct: 414 W 414
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/217 (23%), Positives = 84/217 (38%), Gaps = 10/217 (4%)
Query: 723 YLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSA 782
+ GH +I+ L+ +P VATG + D +WD Q + + L+G H + +L F+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSM--DTTAKLWDIQNGEEVYTLRG-HSAEIISLSFNT 229
Query: 783 DGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKF 842
G +++ D H++V WD G K+ GH +I N L K K
Sbjct: 230 SGDRIITGSFD--HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 843 WQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAH 902
W G + T C Y S T IF + ++ H
Sbjct: 288 WDATNGKCVA---TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGH 344
Query: 903 DGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLK 937
+G + + +G +TG D +WD +CL+
Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Score = 56.6 bits (135), Expect = 2e-07
Identities = 67/309 (21%), Positives = 120/309 (38%), Gaps = 34/309 (11%)
Query: 725 GHDDDILSLTIH-PVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSAD 783
GH + + ++ + P D +ATG D +W +T KC +G H + L F+
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSF--DKTCKLWSVETGKCYHTFRG-HTAEIVCLSFNPQ 188
Query: 784 GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKH-IKF 842
+ + +D + WD + GE++ T RGH +I + N D+++T H +
Sbjct: 189 STLVATGSMDT--TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG-DRIITGSFDHTVVV 245
Query: 843 WQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTVK 900
W G R +G + S+ L+ +G+ +W + + T+
Sbjct: 246 WDADTG-----RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 901 AHDGPVF--AMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDN 958
HD + K T DG ++ +C+ +S + N
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK------ISFN 354
Query: 959 PSIRAITLGHGHILVGT--KNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATV 1016
P H+L G+ K I + ++G +++GH + E++ A + I T
Sbjct: 355 PQ-------GNHLLTGSSDKTARIWDA-QTGQCLQVLEGHTD-EIFSCAFNYKGNIVITG 405
Query: 1017 SDDKTLRIW 1025
S D T RIW
Sbjct: 406 SKDNTCRIW 414
Score = 56.2 bits (134), Expect = 3e-07
Identities = 60/284 (21%), Positives = 113/284 (39%), Gaps = 30/284 (10%)
Query: 1693 LATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGH---AARCAAYSPDGEMVAIGMKN 1749
+A + S FI+ S D T ++WD A + LN + GH A +P G+ +A G +
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLE-GHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 1750 GEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRI- 1808
+ V + K + R + I + +P + +A GS + T +D+ G + +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 1809 GYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVT------EAVVIEKITWA 1862
G+ +I I + F+ G I + + V + G++V + W
Sbjct: 217 GHSAEI----ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWD 272
Query: 1863 SWTSVLG--DEVIGIWPRNADKA---------DVNCACVTHAGLNIVTGDDFGLVKLFDF 1911
+ G D+ +W K ++ +C + G I T G ++F
Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
Query: 1912 PCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
+ AK + GH ++ I F+ +++ TG D + +W
Sbjct: 333 ATRKCIAKLE---GHEGEISKISFNPQGNHLL-TGSSDKTARIW 372
Score = 53.5 bits (127), Expect = 2e-06
Identities = 68/322 (21%), Positives = 124/322 (38%), Gaps = 57/322 (17%)
Query: 784 GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI-KHIKF 842
G C ++ D + WD GE++ T GH++ ++ + N + DK+ T K K
Sbjct: 104 GSCFITGSYD--RTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161
Query: 843 WQ-QAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTV 899
W + G + + RG + +C+S+ LV +G+ +W ++ + T+
Sbjct: 162 WSVETGKCYHTFRGHTAEI------VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 900 KAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSS------- 950
+ H + ++ G +TG D V +WD R + + +S++S
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 951 -------KGLLLEDNPSIRAITLGHGHILVGTKNGEILE--IDKSGPMTLL--------- 992
K L D + + + GH + EIL+ D +G +
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGH------DDEILDSCFDYTGKLIATASADGTARI 329
Query: 993 -----------VQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKK 1041
++GH EGE+ ++ +P T S DKT RIW+ + +
Sbjct: 330 FSAATRKCIAKLEGH-EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388
Query: 1042 GGRCCAFSPDGKALAVGLNDGS 1063
CAF+ G + G D +
Sbjct: 389 EIFSCAFNYKGNIVITGSKDNT 410
Score = 52.8 bits (125), Expect = 3e-06
Identities = 80/353 (22%), Positives = 143/353 (40%), Gaps = 36/353 (10%)
Query: 55 KFFLGHNDDIISLALHPDKTLVATGQVGKEPYIC-IWDSYNVQTVSLLKDVHTHGVACLA 113
K H + ++AL+ + TG + C +WD+ + + ++ L+ H + V +A
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRT---CKLWDTASGEELNTLEG-HRNVVYAIA 141
Query: 114 FDSD-GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVK 172
F++ G ++A+ D T +W GK + GH+ I +S++P
Sbjct: 142 FNNPYGDKIATGSFD--KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDT 199
Query: 173 HIKFWTLCGNALTAKRGIFGKTGDLQTILCLAC-AKEDITYSGALNGDIYVWKG-LNLVR 230
K W + ++ G I+ L+ D +G+ + + VW
Sbjct: 200 TAKLWDIQNG-----EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV 254
Query: 231 TIQGAHSAGIFSM---YACEEGFATGGRDGCIRLWD-TDFKPITKIDLRETEQGYKGLSI 286
I H A I S + C TG D +LWD T+ K + + + E I
Sbjct: 255 NILIGHCAEISSASFNWDCSL-ILTGSMDKTCKLWDATNGKCVATLTGHDDE-------I 306
Query: 287 RSVCWKADRLLAGTQDSE----IFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVT 342
C+ L T ++ IF R K + L+GH EGE+ ++ +P+ +T
Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATR---KCIAKLEGH-EGEISKISFNPQGNHLLT 362
Query: 343 GSDDRSVRLW-SLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLR 394
GS D++ R+W + L + + S AF+ G+ + G KD + + R
Sbjct: 363 GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 52.4 bits (124), Expect = 4e-06
Identities = 76/329 (23%), Positives = 126/329 (38%), Gaps = 42/329 (12%)
Query: 1445 IWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGG 1504
+WD + L+ L H V I F+ ++ G + T +W + G + G
Sbjct: 118 LWDTASGEELNTLEG-HRNVVYAIAFNNPYGDKIATG-SFDKTCKLWSVETGKCYHTFRG 175
Query: 1505 HLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFG 1564
H I + F P S K W + +Y ++S++F
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL-------RGHSAEIISLSFN 228
Query: 1565 AN-NLTFTGAINGDVYVW------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKER 1617
+ + TG+ + V VW K + LI H + + LI+TG ++
Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILI-----GHCAEISSASFNWDCSLILTGSMDK 283
Query: 1618 PTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILV-GTKDGEIIEVGEKNA 1676
KLWD +C A TG E + S GK++ + DG
Sbjct: 284 ------TCKLWDATNGKCVATL--TGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 1677 ASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAAR--CA 1734
++GH EGEI ++ +P + ++ S+D TARIWD + L +V GH
Sbjct: 336 KCIAKLEGH-EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSC 393
Query: 1735 AYSPDGEMVAIGMKNGEFVILLVNSLKVW 1763
A++ G +V G K+ N+ ++W
Sbjct: 394 AFNYKGNIVITGSKD--------NTCRIW 414
Score = 52.4 bits (124), Expect = 4e-06
Identities = 46/183 (25%), Positives = 83/183 (45%), Gaps = 13/183 (7%)
Query: 251 ATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIR-SVCWKADRLLAGTQDSEIFEVI 309
ATG D +LWD I + T +G+ I S DR++ G+ D V+
Sbjct: 193 ATGSMDTTAKLWD-----IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT---VV 244
Query: 310 VRERD--KPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN-ME 366
V + D + + IL GHC E+ + + + L +TGS D++ +LW + +A +
Sbjct: 245 VWDADTGRKVNILIGHC-AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 367 EAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVG 426
+ + F G +A DG+ + + ++ + I ++ F+P G++L G
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTG 363
Query: 427 SND 429
S+D
Sbjct: 364 SSD 366
Score = 51.2 bits (121), Expect = 1e-05
Identities = 52/222 (23%), Positives = 94/222 (42%), Gaps = 24/222 (10%)
Query: 717 QHSQRLYL--GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRG 774
Q+ + +Y GH +I+SL+ + D + TG D + VWD T + +++L G H
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDADTGRKVNILIG-HCAE 263
Query: 775 VCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVT 834
+ + F+ D +++ +D + WD G+ +AT GH D+I +D
Sbjct: 264 ISSASFNWDCSLILTGSMDK--TCKLWDATNGKCVATLTGHDDEI---------LDSCFD 312
Query: 835 VGIKHIKFWQQAGGGFTSKRGTFGSVGKLE----TMMCVSYGRMEDLVFSGAATGDIFIW 890
K I G T + KLE + +S+ + + +G++ IW
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 891 --KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELW 928
+ L+ ++ H +F+ KG +TG KD +W
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 61.6 bits (148), Expect = 7e-09
Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 2/131 (1%)
Query: 315 KPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEA-VRSVA 373
+P+ I GH ++ HP TGS DR+VRLW + + + + + S+
Sbjct: 618 QPLRIFAGHL-ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLT 676
Query: 374 FSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVD 433
FSP+G LA G DG ++ + V +K + + ++FS DG LA GS D V
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVR 736
Query: 434 VYAVAQRYKKI 444
++ + ++ +
Sbjct: 737 LWDAIKAFEDL 747
Score = 55.5 bits (132), Expect = 5e-07
Identities = 56/249 (22%), Positives = 104/249 (41%), Gaps = 25/249 (10%)
Query: 578 VLSTGGADHSVFQWRFIPEGVSNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEA 637
+++ G AD +V W P+ L + Q +ESD L + + + E +
Sbjct: 484 LIAGGFADSTVRVWSVTPK-----KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKI 538
Query: 638 QINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLK-LQFIHGYRGYDCRNNLFY 696
+ VY S ++N+ + + SL+ + GY+G++ ++
Sbjct: 539 LYGHSGPVYGASF------SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP--VWD 590
Query: 697 TQAGEVVYHIAA-----VAVVYNRQQHSQ-RLYLGHDDDILSLTIHPVKDYVATGQVGRD 750
TQ Y+ + VA ++ + R++ GH D+ HP +YVATG D
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA--D 648
Query: 751 AAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIA 810
+ +WD C+ + G H+ + +L FS +G+ L + D ++ WD G +
Sbjct: 649 RTVRLWDVLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDG--RVLLWDIGHGLMVG 705
Query: 811 TTRGHKDKI 819
+GH D +
Sbjct: 706 ELKGHTDTV 714
Score = 55.1 bits (131), Expect = 7e-07
Identities = 56/223 (25%), Positives = 97/223 (43%), Gaps = 22/223 (9%)
Query: 896 LKTVKAHDGPVF-AMYALDKGFV-TGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGL 953
LK + H GPV+ A ++ D+ ++ + +DG V LW CL Y KG
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY-----------KG- 583
Query: 954 LLEDNPSIRAITLGHGHILVGTKNGEILEI---DKSGPMTLLVQGHMEGEVWGLAAHPLL 1010
+ P +G+ V + + + D P+ + GH+ +V HP
Sbjct: 584 --HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA-GHL-ADVNCTRFHPNS 639
Query: 1011 PICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNAD 1070
AT S D+T+R+W++ + + K FSP+G+ LA G DG L+ +
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 1071 TVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVL 1113
+ + + ++FS+D G+ LA S DN V +++ +
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRD-GEILASGSMDNTVRLWDAI 741
Score = 53.1 bits (126), Expect = 3e-06
Identities = 51/230 (22%), Positives = 92/230 (40%), Gaps = 55/230 (23%)
Query: 1649 VRSVCRGKGKILVGTKDGEIIE--VGEKNAASNILIDGHMEGEIWGLATHPSKDLFISAS 1706
+RSV + L+ + +++E + EK A+ ++ GH G ++G + P ++ +S+S
Sbjct: 504 LRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGH-SGPVYGASFSPDRNYLLSSS 562
Query: 1707 NDGTARIWDL-----------------------------------------ADKKLLNKV 1725
DGT R+W L D ++
Sbjct: 563 EDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI 622
Query: 1726 SLGHAA--RCAAYSPDGEMVAIGMKNGE---FVILLVNSLKVWGKKRDRKSAIQDIRISP 1780
GH A C + P+ VA G + + +L N ++++ K I + SP
Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF---TGHKGPIHSLTFSP 679
Query: 1781 DNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYI 1830
+ RFLA G+++ V +D+ G +G K V + FS DG+ +
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGL---MVGELKGHTDTVCSLRFSRDGEIL 726
Score = 48.9 bits (115), Expect = 5e-05
Identities = 58/260 (22%), Positives = 95/260 (36%), Gaps = 63/260 (24%)
Query: 251 ATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIV 310
A G D +R+W K +RSV +D L + ++ E I+
Sbjct: 486 AGGFADSTVRVWSVTPK-----------------KLRSVKQASDLSLIDKESDDVLERIM 528
Query: 311 RERDKPML-ILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSL--------------- 354
E+ L IL GH G ++ + P + ++ S+D +VRLWSL
Sbjct: 529 DEKTASELKILYGH-SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 355 ---------------ADHALIARCNMEE-------------AVRSVAFSPDGSQLALGMK 386
H +AR + V F P+ + +A G
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 387 DGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGE 446
D + + V + V K IH + FSP+G +LA G+ DG V ++ + +GE
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL-MVGE 706
Query: 447 CSKSLSFITHIDWSLDSKYL 466
+ + +S D + L
Sbjct: 707 LKGHTDTVCSLRFSRDGEIL 726
Score = 48.5 bits (114), Expect = 6e-05
Identities = 36/122 (29%), Positives = 57/122 (46%), Gaps = 12/122 (9%)
Query: 38 YFVAG----VGVVYNTREHSQ--KFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWD 91
YFV+G V ++ T +H Q + F GH D+ HP+ VATG + + +WD
Sbjct: 599 YFVSGGHDRVARLWAT-DHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT--VRLWD 655
Query: 92 SYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSD 151
N V + H + L F +G+ LA+ D + V +WD G ++ GH+D
Sbjct: 656 VLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDGR--VLLWDIGHGLMVGELKGHTD 712
Query: 152 RI 153
+
Sbjct: 713 TV 714
Score = 47.0 bits (110), Expect = 2e-04
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 11/101 (10%)
Query: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
R++ GH I SLT P ++ATG D + +WD + LKG H VC+L F
Sbjct: 663 RIFTGHKGPIHSLTFSPNGRFLATGAT--DGRVLLWDIGHGLMVGELKG-HTDTVCSLRF 719
Query: 781 SADGKCLVSVGLDDFHSIVFWDWKKG------EKIATTRGH 815
S DG+ L S +D +++ WD K + T GH
Sbjct: 720 SRDGEILASGSMD--NTVRLWDAIKAFEDLETDDFTTATGH 758
Score = 38.9 bits (89), Expect = 0.050
Identities = 61/279 (21%), Positives = 110/279 (39%), Gaps = 39/279 (13%)
Query: 1567 NLTFTGAINGDVYVWKDHFLIRLVA-KAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAV 1625
N + + +G V +W LV K H PV+ + V+GG +R
Sbjct: 556 NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDR------VA 609
Query: 1626 KLWDQEMKRCRAFQLETGQL--VECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILID 1683
+LW + + ++ G L V C R + G+ D + N +
Sbjct: 610 RLWATD--HYQPLRIFAGHLADVNCTR-FHPNSNYVATGSADRTVRLWDVLNGNCVRIFT 666
Query: 1684 GHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAA--YSPDGE 1741
GH +G I L P+ + + DG +WD+ ++ ++ GH + +S DGE
Sbjct: 667 GH-KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK-GHTDTVCSLRFSRDGE 724
Query: 1742 MVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ 1801
++A G + N++++W D A +D + D+ A G + +L
Sbjct: 725 ILASGSMD--------NTVRLW----DAIKAFED--LETDDFTTATGHINLPENSQELLL 770
Query: 1802 GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQ 1840
GT + K P V+ + F+ + + ++ GAY Q
Sbjct: 771 GTYMT-----KSTP--VVHLHFTR--RNLVLAAGAYSPQ 800
Score = 35.4 bits (80), Expect = 0.55
Identities = 45/175 (25%), Positives = 68/175 (38%), Gaps = 15/175 (8%)
Query: 96 QTVSLLKDVHTHG--VACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRI 153
+T S LK ++ H V +F D L S D TV +W + L GH+ +
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG--TVRLWSLQTFTCLVGYKGHNYPV 588
Query: 154 FDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLAC-AKEDITY 212
+D + PY V + + W A + + G L + C +
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLW-----ATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 213 SGALNGDIYVWKGL--NLVRTIQGAHSAGIFSMYACEEG--FATGGRDGCIRLWD 263
+G+ + + +W L N VR G H I S+ G ATG DG + LWD
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Score = 34.3 bits (77), Expect = 1.2
Identities = 34/178 (19%), Positives = 68/178 (38%), Gaps = 11/178 (6%)
Query: 57 FLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDS 116
+ GHN + P +G G + +W + + Q + + H V C F
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSG--GHDRVARLWATDHYQPLRIFAG-HLADVNCTRFHP 637
Query: 117 DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKF 176
+ +A+ D TV +WD G + TGH I +++ P +
Sbjct: 638 NSNYVATGSAD--RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
Query: 177 WTLCGNALTAKRGIFGKTGDLQTILCLACAKE-DITYSGALNGDIYVWKGLNLVRTIQ 233
W + G+ L + G T+ L +++ +I SG+++ + +W + ++
Sbjct: 696 WDI-GHGLM----VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 33.1 bits (74), Expect = 2.7
Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 16/113 (14%)
Query: 328 LWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKD 387
L A+ + L G D +VR+WS+ L RSV S L+L K+
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL----------RSVK---QASDLSLIDKE 519
Query: 388 GSFIVLRVRDMTEVVHIK---DRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAV 437
++ R+ D +K ++ FSPD +YL S DG V ++++
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 60.1 bits (144), Expect = 2e-08
Identities = 72/313 (23%), Positives = 123/313 (39%), Gaps = 26/313 (8%)
Query: 59 GHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDG 118
GH D+ +L+ D V + I IW+ +Q + + T A +F G
Sbjct: 413 GHRSDVRTLSFSSDNIAVLSAAADS---IKIWNRSTLQCIRTM----TCEYALCSFFVPG 465
Query: 119 QRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWT 178
R +G + ++D G LL + H ++ +S P Q V K +KFW
Sbjct: 466 DRQVVIGTKT-GKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Query: 179 ---LCGNALTAKRGIFGKTGDLQT---ILCLACAKEDITYSGAL---NGDIYVWKGLNLV 229
+ T KR +T LQ +LC++ + + +L I+ L
Sbjct: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
Query: 230 RTIQGAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIR 287
++ G H + M +G ATG D +++W DF K + +
Sbjct: 585 LSLYG-HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS----VMYL 639
Query: 288 SVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDR 347
K+ +D +I + ++ + + L+GH + E+W LA+ P V+ S D+
Sbjct: 640 QFVPKSHLFFTAGKDHKIKQWDA-DKFEHIQTLEGHHQ-EIWCLAVSPSGDYVVSSSHDK 697
Query: 348 SVRLWSLADHALI 360
S+RLW LI
Sbjct: 698 SLRLWERTREPLI 710
Score = 57.0 bits (136), Expect = 2e-07
Identities = 73/321 (22%), Positives = 125/321 (38%), Gaps = 33/321 (10%)
Query: 725 GHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADG 784
GH D+ +L+ D +A D+ I +W+ TL+C+ + ++ +C+ D
Sbjct: 413 GHRSDVRTLSFS--SDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEY--ALCSFFVPGDR 467
Query: 785 KCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQ 844
+ ++ + +D G + T H ++ + +P + K +KFW
Sbjct: 468 QVVIGTKTG---KLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Query: 845 ---QAGGGFTSKRGTFGSVGKL---ETMMCVSYGRMEDLVFSGA--ATGDIFIWKDILLL 896
T KR + L E ++CVSY + L+ T IF +
Sbjct: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
Query: 897 KTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLL 954
++ H PV M G TG D V++W F C K S + +
Sbjct: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK------SLFAHDDSVMY 638
Query: 955 LEDNPSIRAI-TLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPIC 1013
L+ P T G H + + + DK + L +GH + E+W LA P
Sbjct: 639 LQFVPKSHLFFTAGKDHKI------KQWDADKFEHIQTL-EGHHQ-EIWCLAVSPSGDYV 690
Query: 1014 ATVSDDKTLRIWELSAQHRML 1034
+ S DK+LR+WE + + +L
Sbjct: 691 VSSSHDKSLRLWERTREPLIL 711
Score = 55.8 bits (133), Expect = 4e-07
Identities = 55/217 (25%), Positives = 98/217 (45%), Gaps = 27/217 (12%)
Query: 967 GHGHILVGTKNGEILEID-KSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIW 1025
G +++GTK G++ D SG + + H +G +W ++ P T DK+++ W
Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAH-DGALWSMSLSPDQRGFVTGGADKSVKFW 523
Query: 1026 EL------SAQHRMLAVR-----KLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVED 1074
+ ++ + L+V+ +L + C ++SP+ K LAV L D + + DT++
Sbjct: 524 DFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKF 583
Query: 1075 MVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWD 1134
+S + K + + S D G +A S D V I+ + G C S H D
Sbjct: 584 FLSLYGHKLPVICMDISHD-GALIATGSADRNVKIWGL----DFGDCH--KSLFAHDD-- 634
Query: 1135 SRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIE 1171
++ + + LFF A GK H I+ + +K E
Sbjct: 635 ---SVMYLQFVPKSHLFFTA--GKDHKIKQWDADKFE 666
Score = 55.5 bits (132), Expect = 5e-07
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 2/122 (1%)
Query: 1024 IWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKE 1083
IW+L ++L ++ LK+ C SPDG LAVG DGS + + + E V+F+ K
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 1084 MISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVN 1143
I+ +K+ + G+ LA S D + +++V+ + KG IT + R K L V
Sbjct: 109 AITTLKYDQLGGR-LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALF-LREKNLLVT 166
Query: 1144 SG 1145
SG
Sbjct: 167 SG 168
Score = 55.1 bits (131), Expect = 7e-07
Identities = 145/700 (20%), Positives = 257/700 (36%), Gaps = 138/700 (19%)
Query: 1095 GKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEA 1154
G +LAV D + I+++L+ + G + IT + +D G L S + + ++
Sbjct: 77 GLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWD- 135
Query: 1155 PRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDF 1214
+I S + +++ H D + A ++ +LL T
Sbjct: 136 ------VINESGLYRLK-----------------GHKDA--ITQALFLREKNLLVTSGKD 170
Query: 1215 GFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQ 1274
VK + QH FK VGH V + L + L+T G +D+ L +W ++
Sbjct: 171 TMVKWWDLDT--QHC-FKTMVGHRTEVWGLVLLSEEKRLIT-GASDSELRVWDIAYL--- 223
Query: 1275 ESKLVDSEE-------------SDTDVEEDGGYDSDVAREK------------------- 1302
++ D EE DT EDG +++D A E
Sbjct: 224 -QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRV 282
Query: 1303 ---AIDYTTKIYA-------------VSIREMEGTKPHQQLKEV----------SVEERP 1336
A+D T +I A +S +E++ K +++K+ EE P
Sbjct: 283 VNLAVDKTGRILACHGTDSVLELFCILSKKEIQ-KKMDKKMKKARKKAKLHSSKGEEEDP 341
Query: 1337 PVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRG-----FDCRNNLHYLNDGADIIF 1391
V+ +++Q+ +T K + + D + G F +NNL L +
Sbjct: 342 EVNVEMSLQDEIQR--VTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYS-LNPSL 398
Query: 1392 HTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTK 1451
T ++ G H D+ L+ + N+ S SI IW+ T
Sbjct: 399 PTPQPVRTSRITIGG------HRSDVRTLSFSSD----NIAVLS--AAADSIKIWNRSTL 446
Query: 1452 HTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFV 1511
+ + C ++ +F G V +G + ++ G + + H ++
Sbjct: 447 QCIRTMTCEYA----LCSFFVPGDRQVVIGTKTGK-LQLYDLASGNLLETIDAHDGALWS 501
Query: 1512 VEFRPDSDTQFVSVGV-KHMKFWTLAGSALLYKKGVIGSLGAAKMQTM------LSVAFG 1564
+ PD FV+ G K +KFW + + L + +T+ L V++
Sbjct: 502 MSLSPDQ-RGFVTGGADKSVKFWDF--ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYS 558
Query: 1565 ANN-LTFTGAINGDVYV-WKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEG 1622
N L ++ V + + D L H PV M + LI TG +R
Sbjct: 559 PNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRN---- 614
Query: 1623 GAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILI 1682
VK+W + C V ++ V + G KD +I + +
Sbjct: 615 --VKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAG-KDHKIKQWDADKFEHIQTL 671
Query: 1683 DGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLL 1722
+GH + EIW LA PS D +S+S+D + R+W+ + L+
Sbjct: 672 EGHHQ-EIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLI 710
Score = 51.6 bits (122), Expect = 7e-06
Identities = 39/142 (27%), Positives = 66/142 (46%), Gaps = 23/142 (16%)
Query: 325 EGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN---------------MEEAV 369
+G LW+++L P + VTG D+SV+ W D L+ N ++E V
Sbjct: 496 DGALWSMSLSPDQRGFVTGGADKSVKFW---DFELVKDENSTQKRLSVKQTRTLQLDEDV 552
Query: 370 RSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSND 429
V++SP+ LA+ + D + + V + + + K + M S DG+ +A GS D
Sbjct: 553 LCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSAD 612
Query: 430 GPVDVYAVAQRYKKIGECSKSL 451
V ++ + G+C KSL
Sbjct: 613 RNVKIWGL-----DFGDCHKSL 629
Score = 47.8 bits (112), Expect = 1e-04
Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 11/146 (7%)
Query: 798 IVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTF 857
+ WD +KGEKI +G K ++ + +P + V I+ + G G
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSG-----EGNV 101
Query: 858 GSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILL---LKTVKAH-DGPVFAMYALD 913
G + + Y ++ + SG+ DI +W D++ L +K H D A++ +
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVW-DVINESGLYRLKGHKDAITQALFLRE 160
Query: 914 KGF-VTGGKDGIVELWDDMFERCLKT 938
K VT GKD +V+ WD + C KT
Sbjct: 161 KNLLVTSGKDTMVKWWDLDTQHCFKT 186
Score = 46.6 bits (109), Expect = 2e-04
Identities = 64/282 (22%), Positives = 111/282 (39%), Gaps = 33/282 (11%)
Query: 166 VVSCGVKHIKFWTL----CGNALTAKRGI--FGKTGDLQTILCLACAKEDITYSGALNGD 219
V+S IK W C +T + + F GD Q ++ T +G L
Sbjct: 430 VLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIG--------TKTGKLQ-- 479
Query: 220 IYVWKGLNLVRTIQGAHSAGIFSMYAC--EEGFATGGRDGCIRLWDTDF-----KPITKI 272
+Y NL+ TI AH ++SM + GF TGG D ++ WD + ++
Sbjct: 480 LYDLASGNLLETID-AHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRL 538
Query: 273 DLRETEQGYKGLSIRSVCWKAD-RLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWAL 331
+++T + V + + +LLA + ++ + K L L GH + + +
Sbjct: 539 SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH-KLPVICM 597
Query: 332 ALHPKKPLAVTGSDDRSVRLWSL----ADHALIARCNMEEAVRSVAFSPDGSQLALGMKD 387
+ L TGS DR+V++W L +L A +++V + F P KD
Sbjct: 598 DISHDGALIATGSADRNVKIWGLDFGDCHKSLFAH---DDSVMYLQFVPKSHLFFTAGKD 654
Query: 388 GSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSND 429
+ ++ + I + SP G Y+ S+D
Sbjct: 655 HKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD 696
Score = 40.4 bits (93), Expect = 0.017
Identities = 59/286 (20%), Positives = 110/286 (38%), Gaps = 40/286 (13%)
Query: 1678 SNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYS 1737
S I I GH ++ L+ +SA+ D + +IW+ + + + ++ +A C+ +
Sbjct: 407 SRITIGGH-RSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL-CSFFV 463
Query: 1738 PDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFY 1797
P V IG K G+ + + S + A+ + +SPD R G ++ +V F+
Sbjct: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW 523
Query: 1798 DL----TQGTNLNRIGYCK----DIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQ 1849
D + + R+ + + V+ + +S + K + VS ++ V
Sbjct: 524 DFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVD---- 579
Query: 1850 VTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLF 1909
T + S+ G K V C ++H G I TG VK++
Sbjct: 580 ----------TLKFFLSLYG-----------HKLPVICMDISHDGALIATGSADRNVKIW 618
Query: 1910 DFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
+ HK F H V ++F ++ T G D + W
Sbjct: 619 GLDFGD---CHKSLFAHDDSVMYLQF-VPKSHLFFTAGKDHKIKQW 660
Score = 39.3 bits (90), Expect = 0.038
Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 1/117 (0%)
Query: 322 GHCEGELWALALHPKKPLAVTGSDDRSVRLWSLAD-HALIARCNMEEAVRSVAFSPDGSQ 380
G +G + + L +K V V +W L ++ +++ V + SPDG
Sbjct: 20 GSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLH 79
Query: 381 LALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAV 437
LA+G +DGS + + V K I +K+ G LA GS D + V+ V
Sbjct: 80 LAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV 136
Score = 37.4 bits (85), Expect = 0.15
Identities = 33/131 (25%), Positives = 55/131 (41%), Gaps = 1/131 (0%)
Query: 1684 GHMEGEIWGLATHPSKDLFISASNDGTARIWDLAD-KKLLNKVSLGHAARCAAYSPDGEM 1742
G +G I + K +++ IWDL +K+L L C SPDG
Sbjct: 20 GSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLH 79
Query: 1743 VAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQG 1802
+A+G ++G I + S + K+AI ++ LA GS + + +D+
Sbjct: 80 LAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINE 139
Query: 1803 TNLNRIGYCKD 1813
+ L R+ KD
Sbjct: 140 SGLYRLKGHKD 150
Score = 34.3 bits (77), Expect = 1.2
Identities = 48/224 (21%), Positives = 94/224 (41%), Gaps = 18/224 (8%)
Query: 172 KHIKFWTLC-GNALTAKRGIFGKTGDLQTILCLACAKEDITYS-GALNGDIYVWKGLNLV 229
+H+ W L G + +G+ Q + CL + + + + G +G I ++ L+
Sbjct: 45 EHVFIWDLRKGEKILILQGL------KQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
Query: 230 RTIQ-GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSI 286
+ H A I ++ + G A+G +D I +WD I + L + G+K
Sbjct: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV----INESGLYRLK-GHKDAIT 153
Query: 287 RSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDD 346
+++ + LL + + + + + GH E+W L L ++ +TG+ D
Sbjct: 154 QALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGH-RTEVWGLVLLSEEKRLITGASD 212
Query: 347 RSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSF 390
+R+W +A + E + + S G Q L +DG+F
Sbjct: 213 SELRVWDIA-YLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAF 255
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1882 KADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKY 1941
K +V C C + GL++ G + G +++F E + + GH A +T +++
Sbjct: 65 KQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE---GNVTFNGHKAAITTLKYDQLGGR 121
Query: 1942 VVSTGGDDCSVFVW 1955
+ S G D + VW
Sbjct: 122 LAS-GSKDTDIIVW 134
Score = 33.9 bits (76), Expect = 1.6
Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 26/199 (13%)
Query: 745 GQVGRDAAI------HVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSI 798
G+ GR A+ +WD + + + +L+G Q C S DG L +VG +D SI
Sbjct: 33 GEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCP-SPDGLHL-AVGYED-GSI 89
Query: 799 VFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKH--IKFWQQAGGGFTSKRGT 856
+ GE T GHK I +K + + + G K I W ++ G
Sbjct: 90 RIFSLLSGEGNVTFNGHKAAITTLKYD--QLGGRLASGSKDTDIIVWD-----VINESGL 142
Query: 857 FGSVGKLETMMCVSYGRMEDL-VFSGAATGDIFIWKDI---LLLKTVKAHDGPVFAMYAL 912
+ G + + + R ++L V SG T + W D+ KT+ H V+ + L
Sbjct: 143 YRLKGHKDAITQALFLREKNLLVTSGKDT--MVKWWDLDTQHCFKTMVGHRTEVWGLVLL 200
Query: 913 --DKGFVTGGKDGIVELWD 929
+K +TG D + +WD
Sbjct: 201 SEEKRLITGASDSELRVWD 219
Score = 32.7 bits (73), Expect = 3.6
Identities = 34/127 (26%), Positives = 51/127 (40%), Gaps = 10/127 (7%)
Query: 55 KFFL---GHNDDIISLALHPDKTLVATGQVGKEPYICIWD-SYNVQTVSLLKDVHTHGVA 110
KFFL GH +I + + D L+ATG + + IW + SL H V
Sbjct: 582 KFFLSLYGHKLPVICMDISHDGALIATGSADRN--VKIWGLDFGDCHKSLF--AHDDSVM 637
Query: 111 CLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCG 170
L F + G D K + WD K + + + GH I+ ++ P V S
Sbjct: 638 YLQFVPKSHLFFTAGKDHK--IKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSH 695
Query: 171 VKHIKFW 177
K ++ W
Sbjct: 696 DKSLRLW 702
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 60.1 bits (144), Expect = 2e-08
Identities = 42/148 (28%), Positives = 73/148 (49%), Gaps = 2/148 (1%)
Query: 993 VQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDG 1052
++GH G V +H L PI A+ S D +R+W+L ++ ++ AFSPD
Sbjct: 60 LEGHQLGVVSVDISHTL-PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 1053 KALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNV 1112
+ LA G + G + ++ + S R + I I +S D GKYLA + D ++I+++
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPD-GKYLASGAIDGIINIFDI 177
Query: 1113 LTSKRVGICKGASSYITHIDWDSRGKLL 1140
T K + +G + I + + +LL
Sbjct: 178 ATGKLLHTLEGHAMPIRSLTFSPDSQLL 205
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 2/120 (1%)
Query: 320 LQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEA-VRSVAFSPDG 378
L+GH G + ++ + P+A + S D +RLW L + I + ++AFSPD
Sbjct: 60 LEGHQLGVV-SVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 379 SQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA 438
LA G G + V + + R + I + +SPDG YLA G+ DG ++++ +A
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA 178
Score = 55.5 bits (132), Expect = 5e-07
Identities = 44/158 (27%), Positives = 74/158 (46%), Gaps = 8/158 (5%)
Query: 1682 IDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHA-ARCAAYSPDG 1740
++GH G + +H + + S+S D R+WDL + K + + G A A+SPD
Sbjct: 60 LEGHQLGVVSVDISH-TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 1741 EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
+ +A G G+ I V S K R I I SPD ++LA G+ + ++ +D+
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA 178
Query: 1801 QGTNLNRI-GYCKDIPSFVIQMD-----FSADGKYIQV 1832
G L+ + G+ I S D ++D YI++
Sbjct: 179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKI 216
Score = 51.6 bits (122), Expect = 7e-06
Identities = 67/278 (24%), Positives = 111/278 (39%), Gaps = 38/278 (13%)
Query: 321 QGHCEGELWALALHPKKP----LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSP 376
Q H + +W++A K VTGS D V++W D L + ++E V
Sbjct: 13 QAH-DDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71
Query: 377 DGSQLALGMKDGSFIVLRVRDMTEVVHIK--DRKEV-IHEMKFSPDGSYLAVGSNDGPVD 433
L + +R+ D+ IK D V + FSPD YLA G++ G V+
Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVN 131
Query: 434 VYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIK 493
++ V K+ ++ FI I +S D KYL + G + + +GK L + E
Sbjct: 132 IFGVESGKKEYSLDTRG-KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE--- 187
Query: 494 GIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRG 553
I S+ + +S +LV+ D G +K++ ++
Sbjct: 188 ----------------------GHAMPIRSLTFSPDSQLLVTASDDGYIKIYD---VQHA 222
Query: 554 AKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQW 591
GH++ V NV + D +S+ +D SV W
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSS-SSDKSVKVW 259
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/268 (24%), Positives = 108/268 (40%), Gaps = 48/268 (17%)
Query: 213 SGALNGDIYVWKG----LNLVRTIQGAHSAGIFSMYACEEG--FATGGRDGCIRLWDTD- 265
+G+L+ + VWK L+L +++G H G+ S+ A+ D IRLWD +
Sbjct: 37 TGSLDDLVKVWKWRDERLDLQWSLEG-HQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
Query: 266 ------------------FKP----------ITKIDLRETEQGYK-------GLSIRSVC 290
F P + K+++ E G K G I S+
Sbjct: 96 GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIA 155
Query: 291 WKAD-RLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSV 349
+ D + LA I + K + L+GH + +L P L VT SDD +
Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM-PIRSLTFSPDSQLLVTASDDGYI 214
Query: 350 RLWSLADHALIARCNMEEA--VRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 407
+++ + HA +A A V +VAF PD + D S V V T V D
Sbjct: 215 KIYDV-QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDH 273
Query: 408 KEVIHEMKFSPDGSYLAVGSNDGPVDVY 435
++ + +K++ +GS + +D + +Y
Sbjct: 274 QDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/284 (20%), Positives = 108/284 (38%), Gaps = 67/284 (23%)
Query: 1691 WGLATHPSKDLFISASNDGTARIWDLADKKL------------LNKVSLGHAARCAAYSP 1738
WG + + ++ S D ++W D++L + V + H AA S
Sbjct: 24 WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSS 83
Query: 1739 -DGEMVAIGMKNGEFVILL-VNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDF 1796
D + ++NG+ + + + W + SPD+++LA G+ V+
Sbjct: 84 LDAHIRLWDLENGKQIKSIDAGPVDAW-----------TLAFSPDSQYLATGTHVGKVNI 132
Query: 1797 YDLTQGTNLNRIGYCKDI-PSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQV----T 1851
+ + G + Y D F++ + +S DGKY+ + ++ GK +
Sbjct: 133 FGVESG----KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
Query: 1852 EAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDF 1911
A+ I +T++ + +L VT D G +K++D
Sbjct: 189 HAMPIRSLTFSPDSQLL-----------------------------VTASDDGYIKIYD- 218
Query: 1912 PCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVW 1955
+ GH++ V N+ F DD + VS+ D SV VW
Sbjct: 219 --VQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK-SVKVW 259
Score = 45.4 bits (106), Expect = 5e-04
Identities = 37/157 (23%), Positives = 67/157 (42%), Gaps = 4/157 (2%)
Query: 1689 EIWGLATHPSKDLFISASNDGTARIWDL-ADKKLLNKVSLGHAARCAAYSPDGEMVAIGM 1747
+ W LA P + ++ G I+ + + KK + + G AYSPDG+ +A G
Sbjct: 108 DAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGA 167
Query: 1748 KNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNR 1807
+G I + + K+ I+ + SPD++ L S + + YD+ + N
Sbjct: 168 IDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV---QHANL 224
Query: 1808 IGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEV 1844
G S+V+ + F D + S+ +V +V
Sbjct: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 40.4 bits (93), Expect = 0.017
Identities = 29/116 (25%), Positives = 54/116 (46%), Gaps = 9/116 (7%)
Query: 64 IISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHG--VACLAFDSDGQRL 121
I+S+A PD +A+G + I + +++ T LL + H + L F D Q L
Sbjct: 151 ILSIAYSPDGKYLASGAIDG-----IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLL 205
Query: 122 ASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFW 177
+ D + I+D + L + +GH+ + ++++ P + V S K +K W
Sbjct: 206 VTASDDGY--IKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
Score = 32.3 bits (72), Expect = 4.7
Identities = 29/92 (31%), Positives = 41/92 (44%), Gaps = 5/92 (5%)
Query: 1443 IHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASR 1502
I+I+D T L L H+ + + FS +LLV+ D I ++ Q +
Sbjct: 172 INIFDIATGKLLHTLEG-HAMPIRSLTFSPDSQLLVTASDDGY--IKIYDVQHANLAGTL 228
Query: 1503 GGHLERIFVVEFRPDSDTQFVSVGV-KHMKFW 1533
GH + V F PD DT FVS K +K W
Sbjct: 229 SGHASWVLNVAFCPD-DTHFVSSSSDKSVKVW 259
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 58.9 bits (141), Expect = 5e-08
Identities = 77/334 (23%), Positives = 148/334 (44%), Gaps = 33/334 (9%)
Query: 52 HSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWD-SYNVQTVSLLKDV--HTHG 108
++Q+ H +++ D T +ATG K+ + IW + + LLK + H +G
Sbjct: 183 YTQQILTEHCNEVWFCKFSNDGTKLATGS--KDTTVIIWQVDPDTHLLKLLKTLEGHAYG 240
Query: 109 VACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLAS-ATGHSDRIFDISWDPYQPNRVV 167
V+ +A+ D L + G D + + +W+ + G+L + H D + ++W+P R V
Sbjct: 241 VSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNP-DGKRFV 299
Query: 168 SCGVKHIKFW--TLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKG 225
+ G + +F+ L GN L + G+ +Q + CL+ K + Y ++
Sbjct: 300 TGGQRG-QFYQCDLDGNLLDSWEGV-----RVQCLWCLSDGKTVLASDTHQRIRGYNFED 353
Query: 226 LNLVRTIQGAHSAGIFSMYACEEG------FATGGRDGCIRLWDTDFKPITKIDLRETEQ 279
L +Q H I S + G AT G + LWD + + + + Q
Sbjct: 354 LTDRNIVQEDHP--IMSFTISKNGRLALLNVATQG----VHLWDLQDRVLVR-KYQGVTQ 406
Query: 280 GYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKP- 338
G+ + D + +G++D +++ + + + P+ L GH + ++ +P+ P
Sbjct: 407 GFYTIHSCFGGHNEDFIASGSEDHKVY-IWHKRSELPIAELTGHTR-TVNCVSWNPQIPS 464
Query: 339 LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSV 372
+ + SDD +VR+W A I N+EE S+
Sbjct: 465 MMASASDDGTVRIWGPA--PFIDHQNIEEECSSM 496
Score = 39.7 bits (91), Expect = 0.029
Identities = 78/318 (24%), Positives = 131/318 (41%), Gaps = 32/318 (10%)
Query: 1406 SQSFYLEHTDDI-LCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCF--HS 1462
+Q EH +++ C N K +AT TT I D T H L +L+ H+
Sbjct: 184 TQQILTEHCNEVWFCKFSNDGTK----LATGSKDTTVIIWQVDPDT-HLLKLLKTLEGHA 238
Query: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEG-AKVASRGGHLERIFVVEFRPDSDTQ 1521
GV+YI +S LV+ G D + +W Q G + H + + V + PD +
Sbjct: 239 YGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDG-KR 297
Query: 1522 FVSVGVKHMKF-WTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYV 1580
FV+ G + + L G+ L +GV ++Q + ++ G L Y
Sbjct: 298 FVTGGQRGQFYQCDLDGNLLDSWEGV-------RVQCLWCLSDGKTVLASDTHQRIRGYN 350
Query: 1581 WKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWD-QEMKRCRAFQ 1639
++D +V + H FT+ R L+ + V LWD Q+ R +Q
Sbjct: 351 FEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQ--------GVHLWDLQDRVLVRKYQ 402
Query: 1640 LETGQLVECVRSVCRGKGK--ILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHP 1697
T Q + S G + I G++D ++ +++ + GH + ++ +P
Sbjct: 403 GVT-QGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTR-TVNCVSWNP 460
Query: 1698 S-KDLFISASNDGTARIW 1714
+ SAS+DGT RIW
Sbjct: 461 QIPSMMASASDDGTVRIW 478
Score = 34.3 bits (77), Expect = 1.2
Identities = 22/64 (34%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 1894 GLNIVTGDDFGLVKLFDF-PCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCS- 1951
G + TG V ++ P T K GH+ V+ I +S DD Y+V+ G DDCS
Sbjct: 204 GTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSE 263
Query: 1952 VFVW 1955
+++W
Sbjct: 264 LWLW 267
Score = 34.3 bits (77), Expect = 1.2
Identities = 38/173 (21%), Positives = 75/173 (43%), Gaps = 18/173 (10%)
Query: 1658 KILVGTKDGEIIEVGEKNAASNIL-----IDGHMEGEIWGLATHPSKDLFISASNDGTAR 1712
K+ G+KD +I + + + +++L ++GH G + +A P + ++ D +
Sbjct: 206 KLATGSKDTTVI-IWQVDPDTHLLKLLKTLEGHAYGVSY-IAWSPDDNYLVACGPDDCSE 263
Query: 1713 IW--DLADKKLLNKVSLGH--AARCAAYSPDGEMVAIGMKNGEF--VILLVNSLKVWGKK 1766
+W ++ +L K+S H + A++PDG+ G + G+F L N L W
Sbjct: 264 LWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGV 323
Query: 1767 RDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVI 1819
R +Q + D + + + + Y+ T+ N + I SF I
Sbjct: 324 R-----VQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTI 371
Score = 33.1 bits (74), Expect = 2.7
Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 12/105 (11%)
Query: 295 RLLAGTQDSEIFEVIVRERD------KPMLILQGHCEGELWALALHPKKPLAVTGSDDRS 348
+L G++D+ VI+ + D K + L+GH G + L G DD S
Sbjct: 206 KLATGSKDTT---VIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCS 262
Query: 349 -VRLWSLADHALIARCNM--EEAVRSVAFSPDGSQLALGMKDGSF 390
+ LW++ L + + E+++ SVA++PDG + G + G F
Sbjct: 263 ELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF 307
Score = 32.0 bits (71), Expect = 6.1
Identities = 31/113 (27%), Positives = 52/113 (46%), Gaps = 9/113 (7%)
Query: 1046 CAFSPDGKALAVGLNDGSFLV--VNADT--VEDMVSFHHRKEMISDIKFSKDTGKYLAVA 1101
C FS DG LA G D + ++ V+ DT ++ + + +S I +S D YL
Sbjct: 198 CKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPD-DNYLVAC 256
Query: 1102 SHDNFVD--IYNVLTSK-RVGICKGASSYITHIDWDSRGKLLQVNSGAREQLF 1151
D+ + ++NV T + R + + +T + W+ GK V G R Q +
Sbjct: 257 GPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRF-VTGGQRGQFY 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,552,323
Number of Sequences: 37866
Number of extensions: 3399109
Number of successful extensions: 12814
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 169
Number of HSP's that attempted gapping in prelim test: 7988
Number of HSP's gapped (non-prelim): 3609
length of query: 1958
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1841
effective length of database: 13,817,196
effective search space: 25437457836
effective search space used: 25437457836
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.