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Search of human proteins with 221316556
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316556 ATP-binding cassette, sub-family C, member 3
isoform 2 [Homo sapiens]
(572 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 1164 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1107 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 589 e-168
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 589 e-168
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 589 e-168
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 589 e-168
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 589 e-168
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 369 e-102
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 325 5e-89
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 250 2e-66
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 184 2e-46
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 184 2e-46
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 150 4e-36
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 150 4e-36
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 150 4e-36
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 139 5e-33
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 128 2e-29
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 117 3e-26
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 102 1e-21
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 99 1e-20
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 85 2e-16
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 85 2e-16
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 85 2e-16
gi|118582251 URG7 protein isoform 2 [Homo sapiens] 57 6e-08
gi|66529093 ATP-binding cassette, sub-family C, member 5 isoform... 35 0.24
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 30 4.6
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 30 4.6
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 30 4.6
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 30 4.6
gi|34808710 solute carrier family 19 member 1 [Homo sapiens] 30 6.0
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 1164 bits (3010), Expect = 0.0
Identities = 572/572 (100%), Positives = 572/572 (100%)
Query: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
Sbjct: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
Query: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
Sbjct: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
Query: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
Sbjct: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
Query: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
Sbjct: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
Query: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
Sbjct: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
Sbjct: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
Query: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
Sbjct: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
Query: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
Sbjct: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
Query: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
Sbjct: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
Query: 541 CSPFLVRLGTGLGPCLQGSGCPGMARAHWTLP 572
CSPFLVRLGTGLGPCLQGSGCPGMARAHWTLP
Sbjct: 541 CSPFLVRLGTGLGPCLQGSGCPGMARAHWTLP 572
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1107 bits (2862), Expect = 0.0
Identities = 548/550 (99%), Positives = 548/550 (99%)
Query: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
Sbjct: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
Query: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
Sbjct: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
Query: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
Sbjct: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
Query: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
Sbjct: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
Query: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
Sbjct: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
Sbjct: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
Query: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
Sbjct: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
Query: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
Sbjct: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
Query: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
Sbjct: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
Query: 541 CSPFLVRLGT 550
CSPFLV L T
Sbjct: 541 CSPFLVTLIT 550
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVRLGT 550
TFTW+C+PFLV L T
Sbjct: 548 VGTFTWVCTPFLVALCT 564
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVRLGT 550
TFTW+C+PFLV L T
Sbjct: 548 VGTFTWVCTPFLVALCT 564
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVRLGT 550
TFTW+C+PFLV L T
Sbjct: 548 VGTFTWVCTPFLVALCT 564
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVRLGT 550
TFTW+C+PFLV L T
Sbjct: 548 VGTFTWVCTPFLVALCT 564
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVRLGT 550
TFTW+C+PFLV L T
Sbjct: 548 VGTFTWVCTPFLVALCT 564
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 369 bits (946), Expect = e-102
Identities = 210/543 (38%), Positives = 300/543 (55%), Gaps = 9/543 (1%)
Query: 11 GSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLS 70
G W+ L+ CF + WVP +YLWV P YLL++ HH RGY+ +S L
Sbjct: 10 GQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLF 69
Query: 71 KLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQG 130
K KMVLG L + + + + + G AP F + P V TM A LI ER +G
Sbjct: 70 KAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKG 129
Query: 131 VQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACF 190
VQSSGVL +W LC V +P + A G SDP R + Y+ +LV++ +L+C
Sbjct: 130 VQSSGVLFGYWLLCFV---LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCL 186
Query: 191 REKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQ 250
++PPFF NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+
Sbjct: 187 ADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
Query: 251 MVVQQLLEAWRKQEKQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLA 305
+V +L + W + RH KA A K SG E E L +P LKA+
Sbjct: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQ 305
Query: 306 TFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSL 365
F S+FL+ +I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L
Sbjct: 306 VFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTL 365
Query: 366 ILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAP 425
Q + + V ++ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR +
Sbjct: 366 FEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVL 425
Query: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
+LN LW + I++ +LWQ LGPS L +A + L+PLN ++ K Q +QM+ KD
Sbjct: 426 YLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKD 485
Query: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
SR +L S IL K +K + WE +FL +V GIR EL LRT+ L + + ++ S FL
Sbjct: 486 SRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFL 545
Query: 546 VRL 548
V L
Sbjct: 546 VAL 548
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 325 bits (834), Expect = 5e-89
Identities = 202/567 (35%), Positives = 316/567 (55%), Gaps = 41/567 (7%)
Query: 12 SKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHL 69
S FW+S+ + + DL CF+ ++L W+P +LW+ P LL Y R +L
Sbjct: 8 STFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYL 66
Query: 70 SKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQ 129
+K ++ +G LL + PA + L +G +L+ LLIQY R
Sbjct: 67 AK-QVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV--LLIQYSRQW 123
Query: 130 GVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILA 188
VQ +S L +FW L ++C F++ ++ +G+ S+ F+I + + LI +
Sbjct: 124 CVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFISYGFQILILIFS 182
Query: 189 CFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDR 248
F E N + + P + A FLS + + W+ + + GY+ PL +D+W + EE +
Sbjct: 183 AFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
Query: 249 SQMVV--------QQLLEA----WRKQEKQTARHKASAAPGKN---ASGEDEVLLGARPR 293
++ +V ++L +A R+QEK + ++ + PG N + +D ++L +
Sbjct: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEK 294
Query: 294 PRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPM 343
+K S +KAL TF L S KL+ D+ +F++PQLL +LI F S+
Sbjct: 295 KKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRD 354
Query: 344 APSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRA 403
W G+L A L+F +++QS LQ Y+ F GVK RT IM +Y+KAL ++N ++
Sbjct: 355 TYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKE 414
Query: 404 STVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLI 463
TVGE VNLMSVDAQ+ MD+ F+++LWS+ LQI+L+I+FLW+ LGPSVLAGV MVL+I
Sbjct: 415 YTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVI 474
Query: 464 PLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ 523
P+N ++ K + QVK MK KD R+K+M+EIL+GIK+LK +AWEPSF QV+ +R+ EL+
Sbjct: 475 PINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
Query: 524 LLRTAAYLHTTTTFTWMCSPFLVRLGT 550
L + L F + +P LV + T
Sbjct: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVT 561
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 250 bits (639), Expect = 2e-66
Identities = 139/349 (39%), Positives = 202/349 (57%), Gaps = 6/349 (1%)
Query: 205 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQE 264
NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+ +V +L + W +
Sbjct: 10 NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNR 69
Query: 265 KQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
RH KA A K SG E E L +P LKA+ F S+FL+ +
Sbjct: 70 SAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQVFHSTFLLGTLSLI 128
Query: 320 IQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGV 379
I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L Q + + V +
Sbjct: 129 ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQM 188
Query: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
+ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR + +LN LW + I++
Sbjct: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 248
Query: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIK 499
+LWQ LGPS L +A + L+PLN ++ K Q +QM+ KDSR +L S IL K
Sbjct: 249 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 308
Query: 500 VLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVRL 548
+K + WE +FL +V GIR EL LRT+ L + + ++ S FLV L
Sbjct: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVAL 357
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 184 bits (466), Expect = 2e-46
Identities = 102/334 (30%), Positives = 178/334 (53%), Gaps = 30/334 (8%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
Query: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
Query: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 496 NGIKVLKLYAWEPSFLKQVEGIRQGEL-QLLRTA 528
GI+++K+YAWE SF + +R+ E+ ++LR++
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSS 314
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 184 bits (466), Expect = 2e-46
Identities = 102/334 (30%), Positives = 178/334 (53%), Gaps = 30/334 (8%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
Query: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
Query: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 496 NGIKVLKLYAWEPSFLKQVEGIRQGEL-QLLRTA 528
GI+++K+YAWE SF + +R+ E+ ++LR++
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSS 314
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 150 bits (378), Expect = 4e-36
Identities = 131/510 (25%), Positives = 219/510 (42%), Gaps = 64/510 (12%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVRLGT 550
EL L+T A + + F P L T
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 150 bits (378), Expect = 4e-36
Identities = 131/510 (25%), Positives = 219/510 (42%), Gaps = 64/510 (12%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVRLGT 550
EL L+T A + + F P L T
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 150 bits (378), Expect = 4e-36
Identities = 131/510 (25%), Positives = 219/510 (42%), Gaps = 64/510 (12%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVRLGT 550
EL L+T A + + F P L T
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 139 bits (351), Expect = 5e-33
Identities = 76/249 (30%), Positives = 133/249 (53%), Gaps = 5/249 (2%)
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
+AL FG +L KL+ +L F P LLS+L+ F+ P G L A L
Sbjct: 232 RALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYA-LGLAGG 290
Query: 361 MMQSLILQHYYHY-IFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQR 419
+ +LQ+ Y Y ++ ++ R ++ ++Y KAL + S GE +NL+ D++R
Sbjct: 291 AVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPS---RPPTGEALNLLGTDSER 347
Query: 420 FMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVK 479
++ A + W PLQ+ + +Y L+Q +G + + G+ +LL+P+N +A ++ A +
Sbjct: 348 LLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQE 407
Query: 480 QMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTW 539
++ KD+R+KL++E+L+GI+V+K WE + +VE R EL LR YL + W
Sbjct: 408 MLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLW 467
Query: 540 MCSPFLVRL 548
P ++ +
Sbjct: 468 AALPVVISI 476
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 128 bits (321), Expect = 2e-29
Identities = 102/366 (27%), Positives = 164/366 (44%), Gaps = 56/366 (15%)
Query: 215 LSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASA 274
LS+ +WW ++ P++ + + L R+ Q+L EA+ Q +
Sbjct: 225 LSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVR--------- 275
Query: 275 APGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINP----- 329
K+ G GAR + +AL FG ++S+ F+++ DLL F P
Sbjct: 276 ---KDIQGTQ----GAR------AIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFG 322
Query: 330 ----------------QLLSILI----RFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
Q L + F++N +++A L+FL ++Q LQ
Sbjct: 323 IVDHLGKENDVFQPKTQFLGVYFVSSQEFLAN-------AYVLAVLLFLALLLQRTFLQA 375
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRAS--TVGEIVNLMSVDAQRFMDLAPFL 427
Y+ TG+ R I IY K + ++ S T G+I NL+++D + M
Sbjct: 376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLC 435
Query: 428 NLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSR 487
LW+ P+QII+ + L+ LG S L G A ++LL P+ VA K+ Q ++ + R
Sbjct: 436 PNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNER 495
Query: 488 IKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVR 547
+K +E+L GIK+LKLYAWE F +VE R+ E+ LR A + + F P
Sbjct: 496 LKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAV 555
Query: 548 LGTGLG 553
L T +G
Sbjct: 556 LITFVG 561
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 117 bits (293), Expect = 3e-26
Identities = 84/341 (24%), Positives = 155/341 (45%), Gaps = 30/341 (8%)
Query: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267
P A +S+LFF W + GYR LE D++ + D + + ++L W ++
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
Query: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327
A KN P + AL F F+ F + ++ +
Sbjct: 61 ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
Query: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385
P LL +I N S +L GL L ++++L+L + G++ R +
Sbjct: 98 QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
Query: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445
+IY+K L +++ V ++G++V+L+S + +F + + +W APLQ+ L + +W
Sbjct: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
Query: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505
+ L S G+ F+++L + M ++ ++ R+ + SE++ I+ +K Y
Sbjct: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
Query: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLV 546
WE + K +E +RQ EL+L R AAY+ + + S F V
Sbjct: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV 317
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 102 bits (253), Expect = 1e-21
Identities = 77/338 (22%), Positives = 152/338 (44%), Gaps = 29/338 (8%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRH-PLEEKDLWSLKEEDRSQMVVQQLLE 258
+ + +P +AG S + F W + +A ++ L +D+WSL + + S + ++L
Sbjct: 92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLER 151
Query: 259 AWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFK 318
W+++ + P S + + + ++S
Sbjct: 152 LWQEELNEVG-------------------------PDAASLRRVVWIFCRTRLILSIVCL 186
Query: 319 LIQDLLSFINPQ-LLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVT 377
+I L F P ++ L+ + + + L+ + L +++S L + + T
Sbjct: 187 MITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT 246
Query: 378 GVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQI 437
GV+ R I+ + ++K L + N +++ +GE++N+ S D QR + A +LL P+
Sbjct: 247 GVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVA 304
Query: 438 ILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNG 497
IL + + LGP+ G A +L P + F+ K + D R++ M+E+L
Sbjct: 305 ILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTY 364
Query: 498 IKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT 535
IK +K+YAW +F + V+ IR+ E ++L A Y + T
Sbjct: 365 IKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSIT 402
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 99.0 bits (245), Expect = 1e-20
Identities = 80/333 (24%), Positives = 143/333 (42%), Gaps = 36/333 (10%)
Query: 206 PYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEK 265
P P AG LS F W T + + GYR L L L D S ++ W
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
Query: 266 QTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLS 325
++EV AR P K S + + L+ ++ +++
Sbjct: 98 -----------------DEEV---ARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMA 137
Query: 326 FINPQLL-SILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTG 384
I P +L +++ W G + LC + + + + + +RT
Sbjct: 138 AIGPVILIHQILQQTERTSGKVWVG------IGLCIALFATEFTKVFFWALAWAINYRTA 191
Query: 385 IMGVIYRKALVITNSVKRAS----TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA 440
I + LV N V + +VGE++N++S D+ + A F L + P+ ++
Sbjct: 192 IRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
Query: 441 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV 500
+ + LGP+ L G++ V+ IP+ +A AF+ + + D R++ M+E L I++
Sbjct: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Query: 501 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+K+YAWE SF ++ IR+ E +LL A ++ +
Sbjct: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQS 344
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/361 (24%), Positives = 146/361 (40%), Gaps = 47/361 (13%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 P 543
P
Sbjct: 394 P 394
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/361 (24%), Positives = 146/361 (40%), Gaps = 47/361 (13%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 P 543
P
Sbjct: 394 P 394
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/361 (24%), Positives = 146/361 (40%), Gaps = 47/361 (13%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 P 543
P
Sbjct: 394 P 394
>gi|118582251 URG7 protein isoform 2 [Homo sapiens]
Length = 99
Score = 56.6 bits (135), Expect = 6e-08
Identities = 27/68 (39%), Positives = 36/68 (52%)
Query: 11 GSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLS 70
G W+ L+ CF + WVP +YLWV P YLL++ HH RGY+ +S L
Sbjct: 10 GQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLF 69
Query: 71 KLKMVLGV 78
K KMV +
Sbjct: 70 KAKMVAAI 77
>gi|66529093 ATP-binding cassette, sub-family C, member 5 isoform 2
[Homo sapiens]
Length = 208
Score = 34.7 bits (78), Expect = 0.24
Identities = 17/75 (22%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRH-PLEEKDLWSLKEEDRSQMVVQQLLE 258
+ + +P +AG S + F W + +A ++ L +D+WSL + + S + ++L
Sbjct: 92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLER 151
Query: 259 AWRKQEKQTARHKAS 273
W+++ + AS
Sbjct: 152 LWQEELNEVGPDAAS 166
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 30.4 bits (67), Expect = 4.6
Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 28/145 (19%)
Query: 39 WVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHG 98
W C YL A L++L R Y+ ++L L ++L + W ++ L Y
Sbjct: 1586 WDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSIT--PLMY-------- 1635
Query: 99 RAPAPVFFVTP-----------LVVGVTMLLATLLIQY---ERLQGVQS--SGVLIIFWF 142
PA FF P L +G+ +AT +++ ++LQ V V +IF
Sbjct: 1636 --PASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPH 1693
Query: 143 LCVVCAIVPFRSKILLAKAEGEISD 167
C+ ++ +A A + D
Sbjct: 1694 FCLGRGLIDMVRNQAMADAFERLGD 1718
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform
3 [Homo sapiens]
Length = 1951
Score = 30.4 bits (67), Expect = 4.6
Identities = 14/47 (29%), Positives = 30/47 (63%)
Query: 236 EEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASG 282
EE++ +L+E ++ + QQ+LE +KQ+++ A++A ++ SG
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSG 474
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform
2 [Homo sapiens]
Length = 1951
Score = 30.4 bits (67), Expect = 4.6
Identities = 14/47 (29%), Positives = 30/47 (63%)
Query: 236 EEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASG 282
EE++ +L+E ++ + QQ+LE +KQ+++ A++A ++ SG
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSG 474
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform
1 [Homo sapiens]
Length = 2000
Score = 30.4 bits (67), Expect = 4.6
Identities = 14/47 (29%), Positives = 30/47 (63%)
Query: 236 EEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASG 282
EE++ +L+E ++ + QQ+LE +KQ+++ A++A ++ SG
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSG 474
>gi|34808710 solute carrier family 19 member 1 [Homo sapiens]
Length = 591
Score = 30.0 bits (66), Expect = 6.0
Identities = 54/209 (25%), Positives = 85/209 (40%), Gaps = 40/209 (19%)
Query: 16 DSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHLSKLK 73
D N + ++TP S YL V +P +LL YLR+ ++L LS +
Sbjct: 56 DKNFTREQVTNEITPVLSYS--------YLAVLVPVFLLTDYLRY--TPVLLLQGLSFVS 105
Query: 74 MVLGVLLW-CVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
+ L +LL V+ L F+ + A ++ LV +Y+R+ G
Sbjct: 106 VWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPA---------RYQRVAGYS 156
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKIL--LAKAEGEISDPFRFTTF-YIHFALVLSALILAC 189
+ VL+ F S +L L G +S F+T YI A + +++LA
Sbjct: 157 RAAVLLGV-----------FTSSVLGQLLVTVGRVS----FSTLNYISLAFLTFSVVLAL 201
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRL 218
F ++P N D ETSA L R+
Sbjct: 202 FLKRPKRSLFFNRDDRGRCETSASELERM 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.141 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,508,810
Number of Sequences: 37866
Number of extensions: 933026
Number of successful extensions: 2828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2755
Number of HSP's gapped (non-prelim): 40
length of query: 572
length of database: 18,247,518
effective HSP length: 108
effective length of query: 464
effective length of database: 14,157,990
effective search space: 6569307360
effective search space used: 6569307360
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.