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Search of human proteins with 115298674
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115298674 nidogen 1 precursor [Homo sapiens]
(1247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115298674 nidogen 1 precursor [Homo sapiens] 2610 0.0
gi|144953895 nidogen 2 precursor [Homo sapiens] 813 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 203 7e-52
gi|119709832 low density lipoprotein receptor-related protein 5 ... 191 3e-48
gi|148727288 low density lipoprotein receptor-related protein 6 ... 189 1e-47
gi|93102379 low density lipoprotein-related protein 1B precursor... 186 2e-46
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 179 2e-44
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 164 5e-40
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 154 7e-37
gi|61744471 low density lipoprotein receptor-related protein 8 i... 149 2e-35
gi|61744467 low density lipoprotein receptor-related protein 8 i... 149 2e-35
gi|66082554 low density lipoprotein receptor-related protein 8 i... 149 2e-35
gi|65301119 low density lipoprotein receptor-related protein 8 i... 149 2e-35
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 144 5e-34
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 137 6e-32
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 137 6e-32
gi|118572606 hemicentin 1 [Homo sapiens] 137 8e-32
gi|56237021 fibrillin 3 precursor [Homo sapiens] 132 2e-30
gi|66346695 fibrillin 2 precursor [Homo sapiens] 126 1e-28
gi|24430141 fibrillin 1 precursor [Homo sapiens] 125 3e-28
gi|32698824 low density lipoprotein receptor-related protein 5-l... 120 6e-27
gi|209447022 low density lipoprotein receptor-related protein 5-... 120 6e-27
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 117 9e-26
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 117 9e-26
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 117 9e-26
gi|4507157 sortilin-related receptor containing LDLR class A rep... 114 4e-25
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 112 2e-24
gi|40807489 egf-like module containing, mucin-like, hormone rece... 105 2e-22
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 104 5e-22
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 104 5e-22
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 2610 bits (6764), Expect = 0.0
Identities = 1247/1247 (100%), Positives = 1247/1247 (100%)
Query: 1 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS 60
MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS
Sbjct: 1 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV
Sbjct: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
Sbjct: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA
Sbjct: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
Query: 241 NDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT 300
NDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT
Sbjct: 241 NDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT 300
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
Sbjct: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG
Sbjct: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
Sbjct: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS
Sbjct: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV
Sbjct: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV
Sbjct: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT
Sbjct: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV
Sbjct: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD
Sbjct: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL
Sbjct: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW
Sbjct: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQ
Sbjct: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQ 1140
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT
Sbjct: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK
Sbjct: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 813 bits (2100), Expect = 0.0
Identities = 403/922 (43%), Positives = 553/922 (59%), Gaps = 101/922 (10%)
Query: 371 DEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGS 430
D + VF+YN +++TC +N QCS HA C DYATGFCC C + + GNG+ C+ EG+
Sbjct: 469 DNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGA 528
Query: 431 PQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPV 490
P RVNGKV G + VG + P+ F + DLH+Y+V N GR+YTAIS IP+ +LLPL P+
Sbjct: 529 PHRVNGKVSGHLHVGHT--PVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPI 586
Query: 491 GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDT 550
GG+ GW+FA+E+ G +NGFS+ G FT EVTF + I Q G+D +L+I T
Sbjct: 587 GGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKT 646
Query: 551 ELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWR 610
++G+VP + + HI PY ELYHYS S +TS+S+R+Y++T + ++ ++Y+
Sbjct: 647 NIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDYSLTF-----GAINQTWSYRIH 701
Query: 611 QTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQN 670
Q IT+Q C H P+ P+TQQL+VD VF LYN EE++LR+A++N IGPV+E S N
Sbjct: 702 QNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGN 761
Query: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH 730
PCY G+H CDT A C PG +TCEC+ G++GDGR C D +EC+ CG +++C N
Sbjct: 762 PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINL 821
Query: 731 PGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
PG++RCEC GY+F+D+ TC+ + P N CE G H C +A+C++ GGS+++C+C
Sbjct: 822 PGSYRCECRSGYEFADDRHTCILITP--PANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 879
Query: 790 LPGFSGDGQACQDVDE----------------------CQPS------RCHPDAF----- 816
LPG++GDG C DVDE CQP +C PD+
Sbjct: 880 LPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTP 939
Query: 817 ----------------------------------CYNTPGSFTCQCKPGYQGDGFRCVPG 842
C+ + G C G++ G + PG
Sbjct: 940 CEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPG 999
Query: 843 EVEK-------------TRCQHEREHILGAAGAT--DPQRPIPPGLFVPECDAHGHYAPT 887
T C+ RE++L G T D Q +VP+CD GH+ P
Sbjct: 1000 STPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQ-------YVPQCDDLGHFIPL 1052
Query: 888 QCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLL 947
QCHG + +CWCVD+DGREV+GTR++PG TP C+ TVAPP+ + P V P GT LL
Sbjct: 1053 QCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR-PTPRPDVTPPSVGTFLL 1111
Query: 948 FAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
+ Q +I LPL G ++K AK L + +I+G+ +DC ++MVYWTD+ +I RA L
Sbjct: 1112 YTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGL 1171
Query: 1008 H-GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
G EP TI+ L SPEG+A+DH+ R ++WTDS LD+IE A LDG++R+VLF TDLVNP
Sbjct: 1172 ELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNP 1231
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWV 1126
R I D +RGNLYWTDWNR+ PKIETS +DG NRRIL+ D+GLPNGLTFD FS LCW
Sbjct: 1232 RAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWA 1291
Query: 1127 DAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA 1186
DAGT + EC P RR L+YPF++ SY + Y TDW+ + VV+++ + TD
Sbjct: 1292 DAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDE 1351
Query: 1187 FQPHKQTRLYGITTALSQCPQG 1208
+ P +++ LYGIT CP G
Sbjct: 1352 YLPEQRSHLYGITAVYPYCPTG 1373
Score = 197 bits (502), Expect = 4e-50
Identities = 122/269 (45%), Positives = 157/269 (58%), Gaps = 8/269 (2%)
Query: 16 LLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVY 75
LLLPLL+ L ELFP G GD L++GDD S ++L+ L FY+ + +Y
Sbjct: 19 LLLPLLMLR-AAALHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYE-ARFSNLY 76
Query: 76 VTTNGIIATSEPPAKESHPGL-FPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRA 134
V TNGII+T + P + + FP F A+APFLAD+DT+ G G+V YRED SP++ A
Sbjct: 77 VGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLA 136
Query: 135 AECVHRGFPEIS-FQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAI 193
A V GFP + F P+ A + TWE V Y+ R G+ NTFQAVLAS S SYA+
Sbjct: 137 ARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYAL 196
Query: 194 FLYPEDGLQFHTTFSKKENN---QVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLA 250
FLYP +GLQF T K+ N Q+PA V F +G L KS G Y + +SV+NL
Sbjct: 197 FLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDL-KSEGPYFSLTSTEQSVKNLY 255
Query: 251 KSSNSGQQGVWVFEIGSPATTNGVVPADV 279
+ SN G GVW F IGS + + V PA V
Sbjct: 256 QLSNLGIPGVWAFHIGSTSPLDNVRPAAV 284
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 203 bits (517), Expect = 7e-52
Identities = 111/298 (37%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV---IIGLAFDCVDKMVYWTDIT 998
P T+LLF+ G I R+ L+ T +HVP +I L +D VD VY+TD+
Sbjct: 1352 PETYLLFSSRGSIRRISLD------TSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVF 1405
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
I RA L+G T+I + L + +G+AVD + RN++WTD+ + IE ++LDG+ R+VL
Sbjct: 1406 LDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
Query: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDA 1118
L PR I +G L+WTDW KIE + +DG+ R++L+ DLG PNGLT D
Sbjct: 1466 INNSLDEPRAIAVFPRKGYLFWTDWGH-IAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDL 1178
+ ++ WVDA +R E + + R+ + + +PFA+T + +Y+TDW+ S+ +D
Sbjct: 1525 DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 1584
Query: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
+ + + + L I Q G N C VNNGGCTHLC A C CPD
Sbjct: 1585 YSGRNKETVLANVE-GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPD 1641
Score = 198 bits (504), Expect = 2e-50
Identities = 170/570 (29%), Positives = 241/570 (42%), Gaps = 82/570 (14%)
Query: 679 CDTNAACRPGPRTQFTCECSI----GFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTF 734
C ++ CR G +F C+ + G+R DG D D+ S++ + S F
Sbjct: 225 CSSHQPCRSG---EFMCDSGLCINAGWRCDGDA--DCDDQSDERNCTTSMCTAEQ----F 275
Query: 735 RCE---CVE-GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCL 790
RC CV ++ E C D+ NC+ QC + C+
Sbjct: 276 RCHSGRCVRLSWRCDGEDDCADNSDEE----------NCENTGSPQCALDQFLCWNGRCI 325
Query: 791 PGFSGDGQACQDVDEC-QPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRC 849
G + C V++C S P C G C G + V G V+ C
Sbjct: 326 ----GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQ---C 378
Query: 850 QHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTG--YCWCVDRDGREVE 907
+ L G T V EC G Y C S G CWC G E+
Sbjct: 379 TCHTGYRLTEDGHTCQD--------VNECAEEG-YCSQGCTNSEGAFQCWC--ETGYELR 427
Query: 908 GTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
R C + P+ LLFA R+ + ++
Sbjct: 428 PDRRS------CKALGPEPV------------------LLFAN-----RIDIRQVLPHRS 458
Query: 968 EAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIA 1027
E L+ + I L F ++V+W+D+T I RA+L+G ++ L SP G+A
Sbjct: 459 EYTLLLN-NLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLA 517
Query: 1028 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN 1087
VD + ++WTDS RIEVA LDG R+VL +L PR I + G +YWTDW +
Sbjct: 518 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NT 576
Query: 1088 PKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL 1147
P+IE S MDG+ RRI+ L PNGLT D ++ WVDA + E N S RKA+
Sbjct: 577 PRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERAN-LDGSHRKAV 635
Query: 1148 --EGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQC 1205
+GL +PFA+T + +LY+TDW S+ + + K + + + T +
Sbjct: 636 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQ 695
Query: 1206 PQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
P G N C NNGGCTHLCL + + TC CP
Sbjct: 696 PAGKNRCGDNNGGCTHLCLPSGQNYTCACP 725
Score = 192 bits (489), Expect = 1e-48
Identities = 104/266 (39%), Positives = 153/266 (57%), Gaps = 8/266 (3%)
Query: 973 LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
+++ K I + D + VYW+D T I RA+L G + II L + +G+AVD +G
Sbjct: 1076 INITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIG 1135
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
R ++WTD+ +RIEV LDG+ R+VL +L +PR IV G +YWTDW +N K+E
Sbjct: 1136 RKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG-ENAKLER 1194
Query: 1093 SYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY 1152
S MDG++R +L+ ++LG PNGLT D SSQL W DA T R E + + +R + +Q+
Sbjct: 1195 SGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQH 1254
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQC-PQGH 1209
P+ +T +Y+TDW+ S+ D K T + ++ L G+ A+ + P G
Sbjct: 1255 PYGLTLLDSYIYWTDWQTRSIHRAD----KGTGSNVILVRSNLPGLMDMQAVDRAQPLGF 1310
Query: 1210 NYCSVNNGGCTHLCLATPGSRTCRCP 1235
N C NGGC+HLCL P +C CP
Sbjct: 1311 NKCGSRNGGCSHLCLPRPSGFSCACP 1336
Score = 182 bits (462), Expect = 2e-45
Identities = 103/294 (35%), Positives = 154/294 (52%), Gaps = 10/294 (3%)
Query: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
LLFA+ I R+ + + + + L +D D VYWTD++ +I RA
Sbjct: 744 LLFARRMDIRRISFDTEDLSDDVIPL---ADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800
Query: 1006 SLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
G ++ L SP G+A+D + ++WTD+ DRIEVA DG+ R VL +L
Sbjct: 801 KWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 860
Query: 1066 PRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCW 1125
PR IV + + G +YWTDW +PKIE + MD + R++++ +L PNGL D S +L W
Sbjct: 861 PRDIVVEPMGGYMYWTDWGA-SPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYW 919
Query: 1126 VDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE 1183
DAG E S+RK L G L +PF +T YG+ +Y+TDW+ S+ + D +
Sbjct: 920 ADAGMKTIEFAG-LDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLD 978
Query: 1184 TDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCRCP 1235
+ Q + + L I + P C++ NGGC+HLCL +P +C CP
Sbjct: 979 RETLQENLE-NLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCP 1031
Score = 49.3 bits (116), Expect = 2e-05
Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 12/110 (10%)
Query: 653 LSNSIGPVREGSPDALQNPCY--IGTHGCDTN-AACRPG---PRTQFTCECSIGFR--GD 704
L N + + S ++ Q C G C+ N C R C C G+R D
Sbjct: 330 LCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTED 389
Query: 705 GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTCVAV 753
G TC D++EC+E+ C C N G F+C C GY+ D +C A+
Sbjct: 390 GHTCQDVNECAEE-GYCSQG--CTNSEGAFQCWCETGYELRPDRRSCKAL 436
Score = 48.1 bits (113), Expect = 5e-05
Identities = 50/200 (25%), Positives = 69/200 (34%), Gaps = 41/200 (20%)
Query: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV---------- 720
PC G CD+ G R +C + D R C +EQ
Sbjct: 230 PCRSGEFMCDSGLCINAGWRCDGDADCDD--QSDERNCTTSMCTAEQFRCHSGRCVRLSW 287
Query: 721 -CGSHTICNNHPGTFRCE-------------CVEGYQFSDEGTCVAV------VDQRPIN 760
C C ++ CE C G C V D+ P
Sbjct: 288 RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
Query: 761 YCE--TGLHNCDIPQR--AQCIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-QPSRCHP 813
C TG NC++ AQ + C+C G+ + DG CQDV+EC + C
Sbjct: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
Query: 814 DAFCYNTPGSFTCQCKPGYQ 833
C N+ G+F C C+ GY+
Sbjct: 408 G--CTNSEGAFQCWCETGYE 425
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 191 bits (486), Expect = 3e-48
Identities = 104/263 (39%), Positives = 143/263 (54%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR I V G +YWTDW +NPKIE + +DG R
Sbjct: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQER 494
Query: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
R+LV LG PNGL D +L W DA T++ E +N RR LE L + F T
Sbjct: 495 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLL 554
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 555 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 605
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 606 ADRNGGCSHLCFFTPHATRCGCP 628
Score = 188 bits (477), Expect = 3e-47
Identities = 107/293 (36%), Positives = 146/293 (49%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 698
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 699 ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 758
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N LT D
Sbjct: 759 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 816
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L +PF +T Y +Y+TDW ++S+ D
Sbjct: 817 RLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSG 876
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C NNG C LCLA PG C C
Sbjct: 877 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
Score = 187 bits (476), Expect = 4e-47
Identities = 120/315 (38%), Positives = 163/315 (51%), Gaps = 23/315 (7%)
Query: 930 GPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVD 989
G P A PL LLFA + + G + T + L A V F
Sbjct: 24 GCPAPAAASPL-----LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAV----DFQFSK 74
Query: 990 KMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEV 1047
VYWTD++E +I + L+ G ++ L SP+G+A D +G+ ++WTDS +RIEV
Sbjct: 75 GAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEV 134
Query: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
A L+GT R+VLF DL PR I D G +YWTDW + P+IE + MDG+ R+I+V D
Sbjct: 135 ANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSD 193
Query: 1108 LGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFT 1166
+ PNGLT D +L W DA + N R+K +EG L +PFA+T G LY+T
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
Query: 1167 DWKMNSVVALDLAISKETDAFQPHKQTRLYG--ITTALSQ--CPQGHNYCSVNNGGCTHL 1222
DW+ S+ A +K T + + LY LSQ P H C +NGGC+HL
Sbjct: 254 DWQTRSI----HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHL 309
Query: 1223 CLATPGS--RTCRCP 1235
CL +P TC CP
Sbjct: 310 CLLSPSEPFYTCACP 324
Score = 117 bits (294), Expect = 5e-26
Identities = 95/317 (29%), Positives = 141/317 (44%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG--LRNVKA-------------IDYDPL 987
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGS-----PEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P + G P +++D R +FWT +
Sbjct: 988 DKFIYWVDGRQ-NIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATN 1046
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +L G V+ D PR IV ++ RG LY+T+ KIE + +DGT R +L
Sbjct: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Query: 1104 VQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T GK
Sbjct: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPLGLTILGK 1165
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + L GI +S + C+ +NGGC
Sbjct: 1166 HLYWIDRQQQMIERVEKTTGDKRTRIQ-GRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1225 SHICIAKGDGTPRCSCP 1241
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 189 bits (481), Expect = 1e-47
Identities = 110/295 (37%), Positives = 151/295 (51%), Gaps = 8/295 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P LLF++ I R+ LE N A K L FD D +YWTDI+ +
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNV----AIPLTGVKEASALDFDVTDNRIYWTDISLKT 685
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD LG+N++W D+ +RIEV+KLDG R+VL
Sbjct: 686 ISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWK 745
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121
DL +PR + D G +YWT+W PKI+ + MDG+ R LV ++G NGLT D
Sbjct: 746 DLDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR 803
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N +R + L +PF +T Y +Y+TDW S+ +
Sbjct: 804 RLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSG 863
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCP 1235
+ Q H + I S G N C+ +NG C+HLCLA P G C CP
Sbjct: 864 QNRTIIQGHLD-YVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Score = 182 bits (462), Expect = 2e-45
Identities = 113/331 (34%), Positives = 168/331 (50%), Gaps = 16/331 (4%)
Query: 914 GMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTH--------LLFAQTGKIERLPLEGNTMR 965
G + CL + P +Q A PT V L G LL A+ + R+ L+ T
Sbjct: 292 GCSHLCLMSPVKPFYQC-ACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLD--TPD 348
Query: 966 KTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEG 1025
T+ L + I + +D V+ +YWTD +I R+ + G ++ + P+G
Sbjct: 349 FTDIVLQLE-DIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDG 407
Query: 1026 IAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNR 1085
IAVD + RN++WTD+ DRIEV +L+GT R++L DL PR IV D + G +YWTDW
Sbjct: 408 IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG- 466
Query: 1086 DNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK 1145
+ PKIE + +DG++R +LV LG PNGL D ++ W DA T++ E +N RR
Sbjct: 467 EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRV 526
Query: 1146 ALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+E + + F T G +Y+TDW+ S+ + ++ + L G+
Sbjct: 527 LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID--QLPDLMGLKATNVH 584
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
G N C+ NGGC+HLCL P C CP
Sbjct: 585 RVIGSNPCAEENGGCSHLCLYRPQGLRCACP 615
Score = 171 bits (432), Expect = 5e-42
Identities = 97/256 (37%), Positives = 143/256 (55%), Gaps = 19/256 (7%)
Query: 991 MVYWTDITEPSIGRASLHGGEPT-TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
++YW+D++E +I R + E ++ L SP+G+A D LG ++WTDS +RIEV+
Sbjct: 64 LIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSN 123
Query: 1050 LDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109
LDG+ R+VLF +L PR I D G +YWTDW + PKIE + MDG++R I++ ++
Sbjct: 124 LDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EVPKIERAGMDGSSRFIIINSEIY 182
Query: 1110 LPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDW 1168
PNGLT D +L W DA N N +R+ ++G L +PFA+T + LY+TDW
Sbjct: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
Query: 1169 KMNSVVALDLAISK-----ETDAFQPHKQTRLYGITTALSQ--CPQGHNYCSVNNGGCTH 1221
+S++A + + +D F P A SQ P N C ++NGGC+H
Sbjct: 243 STHSILACNKYTGEGLREIHSDIFSPMD-------IHAFSQQRQPNATNPCGIDNGGCSH 295
Query: 1222 LCLATPGS--RTCRCP 1235
LCL +P C CP
Sbjct: 296 LCLMSPVKPFYQCACP 311
Score = 114 bits (284), Expect = 8e-25
Identities = 81/305 (26%), Positives = 144/305 (47%), Gaps = 16/305 (5%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P T LLF+Q I R+ ++ + + +H + + + +D +DK +YW D +
Sbjct: 932 PTTFLLFSQKSAINRMVID--EQQSPDIILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNM 988
Query: 1002 IGRASLHGGEPTTIIRQDLGS------PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
I +A G + T++ + S P +++D R I+WT + I V +LDG
Sbjct: 989 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLT 1115
V+ + + PR +V + +G +Y+T+ +PKIE + +DGT R +L L P L
Sbjct: 1049 GVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
Query: 1116 FDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGKNLYFTDWKMNSV 1173
D+ +L W D+ R E + S + R LE + P +T + LY+ D + +
Sbjct: 1109 LDSRLGKLFWADSDLRRIESSDLS-GANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMI 1167
Query: 1174 VALDLAISKETDAFQPH--KQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSR 1230
+D+ + Q + + ++ + Q + H C+ +NGGC+H+CL G+
Sbjct: 1168 EKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHP-CAQDNGGCSHICLVKGDGTT 1226
Query: 1231 TCRCP 1235
C CP
Sbjct: 1227 RCSCP 1231
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 186 bits (471), Expect = 2e-46
Identities = 105/267 (39%), Positives = 149/267 (55%), Gaps = 12/267 (4%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT-DSN 1041
L F +Y+ D T IGR + G E TI++ DL + EGIAVD +G N++WT D +
Sbjct: 561 LDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
Query: 1042 LDRIEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN-----PKIETSY 1094
I VA+L+ R+ L E ++ +PRGIV D V G +YWTDW D +IE ++
Sbjct: 621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAW 680
Query: 1095 MDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQY 1152
MDG NR+I V + PNGLT D ++ L W DA + E + + R+ G L +
Sbjct: 681 MDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNH 740
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
PF ++ +G +++TD+ S+ LDL S+ T H++ L+G+ + QG N C
Sbjct: 741 PFGLSHHGNYVFWTDYMNGSIFQLDLITSEVT--LLRHERPPLFGLQIYDPRKQQGDNMC 798
Query: 1213 SVNNGGCTHLCLATPGSRTCRCPDNTL 1239
VNNGGC+ LCLA PG R C C DN L
Sbjct: 799 RVNNGGCSTLCLAIPGGRVCACADNQL 825
Score = 160 bits (406), Expect = 5e-39
Identities = 97/275 (35%), Positives = 138/275 (50%), Gaps = 28/275 (10%)
Query: 981 IGLAFDCVDKMVYWTDITEPSI--GRASLHGGEPT--TIIRQDLGSPEGIAVDHLGRNIF 1036
I L F ++YWTD+ E I G+ S GG ++ L +PEG+ VD + NI+
Sbjct: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W DSNLD+IEVAKLDG+ R L + +PR I D G L+WTDW+ + P+IE++ M
Sbjct: 1351 WIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
Query: 1097 GTNRRILVQD--DLGLPNGLTFDAFSSQLCWVDA-----------GTNRAECLNPSQPSR 1143
G R+ + +D PNGLT D F ++ W DA GTN E +
Sbjct: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEII------- 1463
Query: 1144 RKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALS 1203
+ E L +PFAV+ YG +Y+TDW+ N++ + + Q S
Sbjct: 1464 -RGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPS 1522
Query: 1204 QCPQGHNYCSVNN--GGCTHLCLATPG-SRTCRCP 1235
+ PQ N C+ N+ G C+H+CL S C CP
Sbjct: 1523 RQPQAPNPCAANDGKGPCSHMCLINHNRSAACACP 1557
Score = 145 bits (366), Expect = 2e-34
Identities = 154/615 (25%), Positives = 242/615 (39%), Gaps = 132/615 (21%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDEC---SEQP 718
+G D + T GC N C F C + C D+C S++
Sbjct: 2782 DGERDCPDGSDELSTAGCAPNNTC---DENAFMCHNKVCIPKQF-VCDHDDDCGDGSDES 2837
Query: 719 SVCGSHTICNNHPGTFRCECVEG-------YQFSDEGTCVAVVDQRPIN-YCETGLHNCD 770
CG GT C +G +Q + C D+ P+N C++ +C+
Sbjct: 2838 PQCGYRQC-----GTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCN 2892
Query: 771 ----IPQRAQCIYTGG---SSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDAFCYNT 820
+ + +CI +GG + C G D + C ++EC + S C D C +
Sbjct: 2893 SSFFMCKNGRCIPSGGLCDNKDDC----GDGSDERNCH-INECLSKKVSGCSQD--CQDL 2945
Query: 821 PGSFTCQCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC 878
P S+ C+C PG+Q DG CV + EC
Sbjct: 2946 PVSYKCKCWPGFQLKDDGKTCVD---------------------------------IDEC 2972
Query: 879 DAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPC--LSTVAPPIHQGPAVPTA 936
+ G QC + G C+ DG E++ P C LS P
Sbjct: 2973 SS-GFPCSQQCINTYGTYKCLCTDGYEIQ-----PDNPNGCKSLSDEEP----------- 3015
Query: 937 VIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTD 996
L+ A +I ++ +G+ L +I + FD ++ +YW D
Sbjct: 3016 --------FLILADHHEIRKISTDGSNY------TLLKQGLNNVIAIDFDYREEFIYWID 3061
Query: 997 ITEPS---IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGT 1053
+ P+ I R L+G + + + P +AVD +G+N++W+D+ IEV+KL+G
Sbjct: 3062 SSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGL 3119
Query: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
+L L PR + D G LYW D + P I MDGTN+ ++++ + P
Sbjct: 3120 YPTILVSKRLKFPRDLSLDPQAGYLYWIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMA 3178
Query: 1114 LTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA-LEGLQYPFAVTSYGKNLYFTDWKMNS 1172
LT D + +L W D N E N R K + + A+T + +Y+TD K S
Sbjct: 3179 LTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKS 3236
Query: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNY---------CSVNNGGCTHLC 1223
+S+ + + +Y A++ H+Y C +NNGGC+HLC
Sbjct: 3237 -------LSRAHKTSGADRLSLIYS-WHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLC 3288
Query: 1224 LATPG-SRTCRCPDN 1237
L PG + TC CP N
Sbjct: 3289 LLAPGKTHTCACPTN 3303
Score = 131 bits (329), Expect = 5e-30
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 9/275 (3%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+G+ F + +YWTD+ I RA II LG EGIAVD + NI+WTD
Sbjct: 1913 VGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDH 1972
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
+ IEVA+L+G+ R V+ L PR I +G L+WT+W + P I + +DG+ +
Sbjct: 1973 GFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEK 2031
Query: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLN-PSQPSRRKALEGLQYP-FAVTS 1158
+LV + PNG++ D ++L W DA T++ E ++ + +R L G F+V
Sbjct: 2032 VVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAV 2091
Query: 1159 YGKNLYFTD--WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
+G +Y++D SV + ET + L + +G N C+ +N
Sbjct: 2092 FGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDN 2151
Query: 1217 GGCTHLCLATPGS-RTCRCPDNTL---GVDCIEQK 1247
GGC LCL S RTC C L GV C+ +
Sbjct: 2152 GGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHE 2186
Score = 126 bits (316), Expect = 1e-28
Identities = 85/260 (32%), Positives = 129/260 (49%), Gaps = 21/260 (8%)
Query: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD- 1043
FD ++ +YWTDI +I RA ++G T+I +D+ S G+AVD + RN++W S D
Sbjct: 1613 FDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDE 1672
Query: 1044 -RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRI 1102
+I VA+LDG+ + + + P+ + VRG LYWTD N I + MDG+N +I
Sbjct: 1673 TQINVARLDGSLKTSIIH-GIDKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKI 1727
Query: 1103 LVQDDLGLPNGLTFDAFSSQLCWVDAGT---NRAECLNPSQPSRRKALEGLQYPFAVTSY 1159
L Q+ P GL+ D ++L W+ +G NR + E L A+T
Sbjct: 1728 LFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIM 1786
Query: 1160 GKNLYFTDWKMNSVVALDLAISKETDAFQP----HKQTRLYGITTALSQCPQGHNYCSVN 1215
K L++ D + L + D P +K + + + + QG N C +N
Sbjct: 1787 DKKLWWADQNL-----AQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLN 1841
Query: 1216 NGGCTHLCLAT-PGSRTCRC 1234
NGGC+ LCL T +RTC C
Sbjct: 1842 NGGCSQLCLPTSETTRTCMC 1861
Score = 94.0 bits (232), Expect = 8e-19
Identities = 66/273 (24%), Positives = 123/273 (45%), Gaps = 19/273 (6%)
Query: 978 KVIIGLAFDCVDKM-----VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
K +I LAFD + ++++D +I + E +I +++GS EG+A
Sbjct: 2222 KNVIALAFDYNQRRKGTNRIFYSDAHFGNI-QLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQ------RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 1086
++WT S I +D T+ V+ ++ +P + D + ++WT+WN
Sbjct: 2281 DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
Query: 1087 NPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
+P I S + G N +++V D+ PNGLT D + +L + D + E R
Sbjct: 2341 HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
Query: 1147 LEGLQYPF-AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGITTAL 1202
++ F ++ Y ++++DW +++ + +T + PH+ + +
Sbjct: 2401 VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT 2460
Query: 1203 SQCPQGHNYCSVNNGGCTHLCLATPGSR-TCRC 1234
+ C + C++ NGGC LCL TP R C C
Sbjct: 2461 NSCEL--SPCALLNGGCHDLCLLTPNGRVNCSC 2491
Score = 89.0 bits (219), Expect = 3e-17
Identities = 114/468 (24%), Positives = 180/468 (38%), Gaps = 89/468 (19%)
Query: 789 CLPGFSGDGQACQDV-DECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEVE 845
C G+ +G CQ++ CQ C C S C C+ G++ DG C +
Sbjct: 103 CPDGYD-EGVHCQELLSNCQQLNCQYK--CTMVRNSTRCYCEDGFEITEDGRSCKDQD-- 157
Query: 846 KTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPT--QCHGSTGYCWCVDRDG 903
EC +G + T HGS C CV+
Sbjct: 158 -------------------------------ECAVYGTCSQTCRNTHGSYT-CSCVEGYL 185
Query: 904 REVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT 963
+ + + + P T PPI LL A IE L G+
Sbjct: 186 MQPDNRSCKAKIEP----TDRPPI------------------LLIANFETIEVFYLNGSK 223
Query: 964 MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-------IGRASLHGGEPTTII 1016
M + V I L F + M+ W + E S I +A E T I
Sbjct: 224 MATLSS-----VNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
Query: 1017 RQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRG 1076
Q + + +A+D L RN+++ D DRI V +G+ L + +L NP+ I D + G
Sbjct: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
Query: 1077 NLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECL 1136
L++TD+ + K+E MDG NR ++ P L D + + WVD + +
Sbjct: 339 KLFFTDYG-NVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 397
Query: 1137 NPSQPSRRKALEGLQ--YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR 1194
+ +R ++G Q + + +T + LY T+ ++V ++ TD K
Sbjct: 398 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR--FNGTDIHSLIKIEN 455
Query: 1195 LYGIT--TALSQCPQGHNYCSVN----NGGCTHLCLATPG--SRTCRC 1234
+GI +Q + C V+ GGC+H+CL + +RTCRC
Sbjct: 456 AWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
Score = 77.0 bits (188), Expect = 1e-13
Identities = 79/288 (27%), Positives = 109/288 (37%), Gaps = 62/288 (21%)
Query: 989 DKMVYWTDITEPSIGRASLHGGEP----TTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
D +++ T I +HG E + +I + P IAVD + NI+WTD +
Sbjct: 3933 DMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMH 3992
Query: 1045 ---------------IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPK 1089
I V +L+G L P I + RG +YWT D+
Sbjct: 3993 WFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSH 4051
Query: 1090 IETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVD-----------AGTNRAECLNP 1138
IE + MDGT RRILVQ +L P GL D FS ++ W D G+N ++
Sbjct: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
Query: 1139 SQPSRRKALEGLQYPFAVTSYGKNLYFTDWK----------MNSVVALDLAISKETDAFQ 1188
Q GL +P + + +Y K SV L L I K
Sbjct: 4112 KQ--------GLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLI 4163
Query: 1189 PHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
H+ +L P N C + C LCL P TC CP+
Sbjct: 4164 SHRYKQL--------DLP---NPCL--DLACEFLCLLNPSGATCVCPE 4198
Score = 49.7 bits (117), Expect = 2e-05
Identities = 48/150 (32%), Positives = 64/150 (42%), Gaps = 43/150 (28%)
Query: 711 IDECSEQPSV-CG-SHTICNNHPGTFRC-----------ECVEGYQFSDEGTCVAVVDQR 757
+D C E+ + C +H C GT +C +C +GY DEG
Sbjct: 66 LDTCPEEVEIKCPLNHIACL---GTNKCVHLSQLCNGVLDCPDGY---DEGV-------- 111
Query: 758 PINYCETGLHNCDIPQRAQCIYTGG---SSYTCSCLPGF--SGDGQACQDVDECQP-SRC 811
+C+ L NC Q+ C Y +S C C GF + DG++C+D DEC C
Sbjct: 112 ---HCQELLSNC---QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTC 165
Query: 812 HPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
C NT GS+TC C GY Q D C
Sbjct: 166 SQT--CRNTHGSYTCSCVEGYLMQPDNRSC 193
Score = 47.4 bits (111), Expect = 9e-05
Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC + + PG +C + D +TC +D CS
Sbjct: 1165 DGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK- 1223
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
C +C H T +C C EG++ +G VD
Sbjct: 1224 CSQ--VCEQHKHTVKCSCYEGWKLDVDGESCTSVD 1256
Score = 45.4 bits (106), Expect = 3e-04
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 690 RTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-D 746
R C C GF DGR+C D DEC+ C C N G++ C CVEGY D
Sbjct: 133 RNSTRCYCEDGFEITEDGRSCKDQDECAVY-GTCSQ--TCRNTHGSYTCSCVEGYLMQPD 189
Query: 747 EGTCVAVVD 755
+C A ++
Sbjct: 190 NRSCKAKIE 198
Score = 41.2 bits (95), Expect = 0.006
Identities = 46/179 (25%), Positives = 65/179 (36%), Gaps = 33/179 (18%)
Query: 677 HGCDTNAACRPGPRTQFTC----ECSIGFRGD---GRTCYDIDECSEQPSVCGSHTICNN 729
H C N C +++ C EC D G+ Y C + C +
Sbjct: 3721 HRCRNNRICL---QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCI-- 3775
Query: 730 HPGTFRCE----CVEGYQFSDEGTCVAVVDQRPINY-CETGLHNCDIPQRAQCIYTGGSS 784
P +C+ C +G SDE C P Y CE ++ C I T S
Sbjct: 3776 -PMDLQCDRLDDCGDG---SDEQGCRIA----PTEYTCEDNVNPCGDDAYCNQIKT---S 3824
Query: 785 YTCSCLPGFSGD--GQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
C C PGF + + C+D++EC C C N GS+ C C +Q C+
Sbjct: 3825 VFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQ--CINVEGSYKCVCDQNFQERNNTCI 3881
Score = 40.8 bits (94), Expect = 0.008
Identities = 47/184 (25%), Positives = 62/184 (33%), Gaps = 59/184 (32%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C C P + TC C++GF G CG T+C + C
Sbjct: 4257 CQNGGTCVPSVLGRPTCSCALGFTGPN---------------CGK-TVCEDF-------C 4293
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCE---TG--------LHNCDIPQRAQCIYTGGSSYTC 787
G GTC+ +P +C+ TG H C C S C
Sbjct: 4294 QNG------GTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYC--VNSESCTIGDDGSVEC 4345
Query: 788 SCLPGFSGDGQACQDVDECQPSRCH----------PDAFCYNTPGSF--TCQCKPGYQGD 835
C + +G C +VD+C RCH D FC T G +CQ GY +
Sbjct: 4346 VCPTRY--EGPKC-EVDKC--VRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYN 4400
Query: 836 GFRC 839
G C
Sbjct: 4401 GGTC 4404
Score = 39.7 bits (91), Expect = 0.018
Identities = 52/219 (23%), Positives = 77/219 (35%), Gaps = 62/219 (28%)
Query: 726 ICNNHPGTFRCECVEGYQFSDEGTCV--AVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
+C +P C C EG ++ GTC +++D CE G +CI
Sbjct: 4184 LCLLNPSGATCVCPEG-KYLINGTCNDDSLLDDSCKLTCENG---------GRCILNEKG 4233
Query: 784 SYTCSCLPGFSGD-------GQACQDVDECQPS-------------------------RC 811
C C P +SG+ CQ+ C PS C
Sbjct: 4234 DLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFC 4293
Query: 812 HPDAFCYNTPGSFT-CQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATD---PQR 867
C T G+ C C+P Y GD RC V C + +G G+ + P R
Sbjct: 4294 QNGGTCIVTAGNQPYCHCQPEYTGD--RC-QYYVCHHYCVNSESCTIGDDGSVECVCPTR 4350
Query: 868 PIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 906
P V +C +CHG G+C +++D ++
Sbjct: 4351 YEGPKCEVDKC--------VRCHG--GHC-IINKDSEDI 4378
Score = 38.5 bits (88), Expect = 0.040
Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+GL+ D V+ +YW +I R +L GG I + A+ + + ++W D
Sbjct: 1736 VGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQ 1795
Query: 1041 NLDRI-EVAKLDGTQRRVL 1058
NL ++ +K DG +L
Sbjct: 1796 NLAQLGTCSKRDGRNPTIL 1814
Score = 35.4 bits (80), Expect = 0.34
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 1205 CPQGHNY------CSVNNGGCTHLCLATPG-SRTCRCPD 1236
CP G + CS+NNGGC++ C PG C CP+
Sbjct: 1163 CPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPE 1201
Score = 33.1 bits (74), Expect = 1.7
Identities = 36/145 (24%), Positives = 52/145 (35%), Gaps = 32/145 (22%)
Query: 722 GSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
G T+C PG C C + + G TC + + C+ G C + CI
Sbjct: 804 GCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRC---KNRHCIQ- 859
Query: 781 GGSSYTC----SCLPGFSGDGQAC------QDVDECQPSRCHPDAFCYN----------- 819
+ + C CL G D C D +CQ +RC P + +
Sbjct: 860 --ARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE 917
Query: 820 ---TPGSFTCQCKPGYQGDGFRCVP 841
T + TCQ G+G RC+P
Sbjct: 918 SNQTCTARTCQVDQFSCGNG-RCIP 941
Score = 33.1 bits (74), Expect = 1.7
Identities = 48/190 (25%), Positives = 66/190 (34%), Gaps = 31/190 (16%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCG 722
PD ++ C I GC + C P TC C F D RTC + C+ C
Sbjct: 3270 PDVSKHLCMINNGGC--SHLCLLAPGKTHTCACPTNFYLAADNRTC--LSNCTASQFRCK 3325
Query: 723 SHTICNNHPGTFRCECVE--GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQ-----RA 775
+ P ++C+ V+ G + C Q C TGL C +P
Sbjct: 3326 TDKCI---PFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGL--CALPAFICDGEN 3380
Query: 776 QCIYTGGSSYTCSCLPGFSGDGQ-ACQDVDECQP--SRCHPDAFCYNTPGSFTC---QCK 829
C G +S +C GQ C +C P RC+ C + C C
Sbjct: 3381 DC---GDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS 3437
Query: 830 PGYQGDGFRC 839
P Y F+C
Sbjct: 3438 PDY----FQC 3443
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 179 bits (453), Expect = 2e-44
Identities = 162/599 (27%), Positives = 241/599 (40%), Gaps = 112/599 (18%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH-------- 730
CD + C G C TC D + + H +C++
Sbjct: 2794 CDGDKDCADGADESIAAGCLYN-----STCDDREFMCQNRQCIPKHFVCDHDRDCADGSD 2848
Query: 731 -----------PGTFRC---ECVEGYQFSDEGT--CVAVVDQRPIN-YCETGLHNCDIPQ 773
P FRC C+ Q+ +G C D+ P N +C + H C+
Sbjct: 2849 ESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASS 2908
Query: 774 RAQCIYTGGSSYTCSCLP----GFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTC 826
+ C + C G S D + C ++EC + S C D C + F C
Sbjct: 2909 QFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQD--CEDLKIGFKC 2965
Query: 827 QCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHY 884
+C+PG++ DG C + T + I + HG Y
Sbjct: 2966 RCRPGFRLKDDGRTCADVDECSTTFPCSQRCI----------------------NTHGSY 3003
Query: 885 APTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGT 944
C CV EG R G C AV P
Sbjct: 3004 K----------CLCV-------EGYAPRGGDPHSC---------------KAVTDEEP-- 3029
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS--I 1002
L+FA + +L L+G+ L + L FD ++M+YWTD+T I
Sbjct: 3030 FLIFANRYYLRKLNLDGSNY------TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
Query: 1003 GRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETD 1062
R L+G + R L +P+G+AVD +G N++W D D IEV+KL+G R VL +
Sbjct: 3084 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG 3143
Query: 1063 LVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQ 1122
L PR +V D G LYWTDW D+ I MDG++R ++V + PNGLT D + +
Sbjct: 3144 LREPRALVVDVQNGYLYWTDWG-DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTER 3202
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKMNSV--VALDLA 1179
+ W DA + E + +R L + + + FA+T + +Y+TDW+ S+
Sbjct: 3203 IYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
Query: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDN 1237
+K H+ L+ + AL Q ++ C VNNGGC++LCL +P G C CP N
Sbjct: 3263 TNKTLLISTLHRPMDLH-VFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTN 3320
Score = 162 bits (410), Expect = 2e-39
Identities = 97/268 (36%), Positives = 136/268 (50%), Gaps = 14/268 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT----IIRQDLGSPEGIAVDHLGRNIF 1036
I L F +YWTD+ E I R L T +I+ L +PEG+AVD + NI+
Sbjct: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W +SNLD+IEVAKLDGT R L D+ +PR I D G L+WTDW+ P+IE + M
Sbjct: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
Query: 1097 GTNRRILVQD--DLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQ 1151
G RR + ++ G PNGLT D ++ W+DA ++ + L G L
Sbjct: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQGHN 1210
+PFAVT YG +Y+TDW+ N++ + Q T+ + + S+ P N
Sbjct: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ-RTNTQPFDLQVYHPSRQPMAPN 1538
Query: 1211 YCSVN--NGGCTHLCLATPG-SRTCRCP 1235
C N G C+HLCL + +C CP
Sbjct: 1539 PCEANGGQGPCSHLCLINYNRTVSCACP 1566
Score = 161 bits (407), Expect = 4e-39
Identities = 99/280 (35%), Positives = 152/280 (54%), Gaps = 18/280 (6%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L F +Y+ D T IGR + G E TI++ + + EG+AVD +G N++WTD
Sbjct: 564 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP 623
Query: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D ++E ++
Sbjct: 624 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAW 683
Query: 1095 MDGTNRRILVQDDLGL-PNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
MDG++R I V L PNGL+ D + +L WVDA +R E + + R+ EG L
Sbjct: 684 MDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN 743
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAI--SKETDAFQPHKQTRLYGITTALSQCPQ-G 1208
+ F + +G L++T+++ SV L+ + + T ++ ++ I +Q Q G
Sbjct: 744 HAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVG 803
Query: 1209 HNYCSVNNGGCTHLCLATPGSRTCRCPDNTL----GVDCI 1244
N C VNNGGC+ LCLATPGSR C C ++ + GV C+
Sbjct: 804 TNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCL 843
Score = 138 bits (347), Expect = 4e-32
Identities = 98/333 (29%), Positives = 154/333 (46%), Gaps = 16/333 (4%)
Query: 916 TPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHV 975
T C+ T + G V G+ LL++ I +PL+ N ++ A + V
Sbjct: 1868 TRSCMCTAGYSLRSGQQACEGV-----GSFLLYSVHEGIRGIPLDPND----KSDALVPV 1918
Query: 976 PA-KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRN 1034
+ +G+ F + +YW D+ +I RA ++ +G EGIAVD + N
Sbjct: 1919 SGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGN 1978
Query: 1035 IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSY 1094
I+WTD D IEVA+L+G+ R V+ L PR I +G L+WT+W + P+IE S
Sbjct: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ-YPRIERSR 2037
Query: 1095 MDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL--EGLQY 1152
+DGT R +LV + PNG++ D +L W DA T++ E ++ R+ +
Sbjct: 2038 LDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMD 2097
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA--FQPHKQTRLYGITTALSQCPQGHN 1210
F+V+ + +Y++D + + TD+ + +L I +G N
Sbjct: 2098 MFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTN 2157
Query: 1211 YCSVNNGGCTHLCL-ATPGSRTCRCPDNTLGVD 1242
C+V NGGC LCL G R C C L D
Sbjct: 2158 VCAVANGGCQQLCLYRGRGQRACACAHGMLAED 2190
Score = 125 bits (315), Expect = 2e-28
Identities = 89/278 (32%), Positives = 126/278 (45%), Gaps = 51/278 (18%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQD---------------LGSPEGIAVDHLGRNIF 1036
VYWT+ +I SL P T + L P GIA+D + N++
Sbjct: 3914 VYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVY 3973
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
WTDS D IEVA++ G R+ L + P IV D +RG +YW+DW ++PKIET+ MD
Sbjct: 3974 WTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG-NHPKIETAAMD 4032
Query: 1097 GTNRRILVQDDLGLPNGLTFDAFSSQLCWVDA-----GTNRAECLNPSQPSRRKALEGLQ 1151
GT R LVQD++ P GL D + +L W DA G+ R +P + K GL
Sbjct: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSK--RGLS 4090
Query: 1152 YPFAVTSYGKNLYFTDWKMNSV-----------VALDLAISKETDA--FQPHKQTRLYGI 1198
+PF++ + +Y + N V V L +S +D + HKQ
Sbjct: 4091 HPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQ------ 4144
Query: 1199 TTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
P+ N C + C LCL +P C CP+
Sbjct: 4145 -------PEVTNPC--DRKKCEWLCLLSPSGPVCTCPN 4173
Score = 121 bits (303), Expect = 5e-27
Identities = 85/265 (32%), Positives = 134/265 (50%), Gaps = 24/265 (9%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT--DS 1040
L +D ++ VYW+D+ +I RA ++G T++ DL + G+AVD + RN+FWT D+
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDT 1679
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
N +I VA+LDG+ + + + L P G+V +RG LYWT D I + MDG+NR
Sbjct: 1680 NKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWT----DGDNISMANMDGSNR 1734
Query: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPF----AV 1156
+L G P GL D S+L W+ +G + N S + ++ ++ A+
Sbjct: 1735 TLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCN-LDGSGLEVIDAMRSQLGKATAL 1792
Query: 1157 TSYGKNLYFTDW---KMNSVVALD---LAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
G L++ D KM + D + + + H ++Y + L +G N
Sbjct: 1793 AIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMH--MKVYDESIQLDH--KGTN 1848
Query: 1211 YCSVNNGGCTHLCLAT-PGSRTCRC 1234
CSVNNG C+ LCL T +R+C C
Sbjct: 1849 PCSVNNGDCSQLCLPTSETTRSCMC 1873
Score = 103 bits (258), Expect = 8e-22
Identities = 74/276 (26%), Positives = 125/276 (45%), Gaps = 23/276 (8%)
Query: 978 KVIIGLAFDC-------VDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
K +I LAFD ++++DI +I + + G TI+ +++GS EG+A
Sbjct: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIV-ENVGSVEGLAYHR 2292
Query: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLV-------NPRGIVTDSVRGNLYWTDW 1083
++WT I +D T R FE + V +PR V D + ++WT+W
Sbjct: 2293 GWDTLYWTSYTTSTITRHTVDQT-RPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
Query: 1084 NRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSR 1143
N +P I + + G N L++ D+ PNGL D + +L + DA ++ E R
Sbjct: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
Query: 1144 RKALEGLQ-YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGIT 1199
L+ +PF + YG+++++TDW +V + + + P + + +
Sbjct: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
Query: 1200 TALSQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRC 1234
+ C + C +NNGGC LCL T G C C
Sbjct: 2472 NDTNSCEL--SPCRINNGGCQDLCLLTHQGHVNCSC 2505
Score = 89.0 bits (219), Expect = 3e-17
Identities = 114/480 (23%), Positives = 185/480 (38%), Gaps = 52/480 (10%)
Query: 795 GDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHERE 854
G +A + + + RC P+ +N G+ C C+ G E C+
Sbjct: 56 GSDEAPEICPQSKAQRCQPNE--HNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRE--- 110
Query: 855 HILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGT----- 909
+ G Q P L P C + + Q G T C D D V GT
Sbjct: 111 -LQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ-LQADGKT----CKDFDECSVYGTCSQLC 164
Query: 910 -RTRPGMTPPCLST-VAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
T C+ + P ++ + PP LL A + I L G
Sbjct: 165 TNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV--LLIANSQNILATYLSG-----A 217
Query: 968 EAKAFLHVPAKVIIGLAFDCVDKMVYWTDI----TEPSIGRASLHG-----GEPTTIIRQ 1018
+ + + F ++ V W + + + A + G E T I
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 1019 DLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNL 1078
L E +A+D L N ++ D DRI V +G L + +L NP+GI D G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 1079 YWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNP 1138
++TD+ + PK+E MDG NR LV + P+G+T D S + W DA + E ++
Sbjct: 338 FFTDYGQ-IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDY 396
Query: 1139 SQPSRRKALEG--LQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH 1190
R+ ++G +++ + +T + LY T+ + SV+ ++ S E
Sbjct: 397 EGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRV 456
Query: 1191 KQTRLYGITTALSQCPQGHNYCSVNN-----GGCTHLCLATPG--SRTCRCPDN-TLGVD 1242
+ I Q P+ ++ N+ GGC+ +CL +RTCRC +LG D
Sbjct: 457 DKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
Score = 50.4 bits (119), Expect = 1e-05
Identities = 43/121 (35%), Positives = 55/121 (45%), Gaps = 25/121 (20%)
Query: 653 LSNSIGPVREGSPDA-----LQNPCYIGTHGCDTNAACRP---GPRTQFTCECSIGFR-- 702
L N + +GS + LQ C GC + C P GP TC C+ F+
Sbjct: 91 LCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHH--CVPTLDGP----TCYCNSSFQLQ 142
Query: 703 GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCVA---VVDQRP 758
DG+TC D DECS C +C N G+F C CVEGY D +C A VD+ P
Sbjct: 143 ADGKTCKDFDECSVY-GTCSQ--LCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPP 199
Query: 759 I 759
+
Sbjct: 200 V 200
Score = 50.1 bits (118), Expect = 1e-05
Identities = 55/175 (31%), Positives = 68/175 (38%), Gaps = 23/175 (13%)
Query: 680 DTNAACRPGP---RTQFTCECSIGFRGDG-RTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
D C P R Q TC S G+R DG R C D + E P +C P
Sbjct: 22 DAPKTCSPKQFACRDQITC-ISKGWRCDGERDCPDGSD--EAPEICPQSKAQRCQPNEHN 78
Query: 736 CE----CVEGYQFSDE-GTCVAVVDQRPINYCETGLHNCD-IPQRAQCIYTGGSSYTCSC 789
C CV + + C+ D+ P +C NC + + C+ T TC C
Sbjct: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGP--HCRELQGNCSRLGCQHHCVPTLDGP-TCYC 135
Query: 790 LPGFS--GDGQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
F DG+ C+D DEC C C NT GSF C C GY Q D C
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGYLLQPDNRSC 188
Score = 47.0 bits (110), Expect = 1e-04
Identities = 50/180 (27%), Positives = 65/180 (36%), Gaps = 45/180 (25%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP-GTFRCE 737
C +C R Q C C + GD C ++D+C E C + C P G C
Sbjct: 4204 CFNGGSCFLNARRQPKCRCQPRYTGD--KC-ELDQCWEH---CRNGGTCAASPSGMPTCR 4257
Query: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDG 797
C G+ T Q YC + C G+ C CLPGF G
Sbjct: 4258 CPTGF------TGPKCTQQVCAGYCANN---------STCTVNQGNQPQCRCLPGFLG-- 4300
Query: 798 QACQDVDECQPSRCHPDAFCYN-------TPGSFTCQCKPGYQGDGFRCVPGEVEK-TRC 849
D CQ +C +C N GS C+C ++G RC EV K +RC
Sbjct: 4301 ------DRCQYRQC--SGYCENFGTCQMAADGSRQCRCTAYFEGS--RC---EVNKCSRC 4347
Score = 43.9 bits (102), Expect = 0.001
Identities = 49/206 (23%), Positives = 68/206 (33%), Gaps = 53/206 (25%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
PD +PC + GC PG + C + DGRTC + C+ VC +
Sbjct: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC--VSNCTASQFVCKND 3344
Query: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
P ++C+ + SDE RP + C TG+
Sbjct: 3345 KCI---PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3401
Query: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDA 815
NCDI P + +C T C+PG C D C + R P+
Sbjct: 3402 NSDEANCDIHVCLPSQFKCTNTN------RCIPGIF----RCNGQDNCGDGEDERDCPEV 3451
Query: 816 FCYNTPGSFTCQCKPGYQGDGFRCVP 841
C P F C RC+P
Sbjct: 3452 TC--APNQFQCSITK-------RCIP 3468
Score = 37.0 bits (84), Expect = 0.12
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 12/151 (7%)
Query: 929 QGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
QG P ++ P L + I ++G+ + L K +GLA D
Sbjct: 1699 QGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSN------RTLLFSGQKGPVGLAIDFP 1752
Query: 989 DKMVYWTDITEPSIGRASLHGG--EPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI- 1045
+ +YW +I R +L G E +R LG +A+ +G ++W D +++
Sbjct: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAI--MGDKLWWADQVSEKMG 1810
Query: 1046 EVAKLDGTQRRVL-FETDLVNPRGIVTDSVR 1075
+K DG+ VL T LV + +S++
Sbjct: 1811 TCSKADGSGSVVLRNSTTLVMHMKVYDESIQ 1841
Score = 36.6 bits (83), Expect = 0.15
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 1212 CSVNNGGCTHLCLATPGSR-TCRCP 1235
CS+NNGGC+H C PG C CP
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCP 1209
Score = 36.2 bits (82), Expect = 0.20
Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC N + PG +C + D TC C++
Sbjct: 1174 DGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK- 1232
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
C C+ + + +C C EG+ +G +D
Sbjct: 1233 CSQK--CDQNKFSVKCSCYEGWVLEPDGESCRSLD 1265
Score = 35.8 bits (81), Expect = 0.26
Identities = 23/109 (21%), Positives = 43/109 (39%), Gaps = 16/109 (14%)
Query: 1076 GNLYWTDWN------RDNPKIETSYMDGTNRRILVQ-------DDLGLPNGLTFDAFSSQ 1122
G +YWT+W+ R P +RR + + L +P G+ D +
Sbjct: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKALEGL---QYPFAVTSYGKNLYFTDW 1168
+ W D+G + E +R+ + G+ + V +Y++DW
Sbjct: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4020
Score = 33.1 bits (74), Expect = 1.7
Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 30/156 (19%)
Query: 722 GSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
G ++C PG+ +C C E +G TC+A P C+ G C ++CI
Sbjct: 813 GCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFAC---ANSRCIQ- 868
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
+ C GD + DE P+ CH TC ++ + RC+
Sbjct: 869 --ERWKC------DGDNDCLDNSDEA-PALCH----------QHTCP-SDRFKCENNRCI 908
Query: 841 PGEVEKTRCQHERE--HILGAAGATDPQRPIPPGLF 874
P + C + + + + AT R PP F
Sbjct: 909 P---NRWLCDGDNDCGNSEDESNATCSARTCPPNQF 941
Score = 31.2 bits (69), Expect = 6.5
Identities = 22/56 (39%), Positives = 26/56 (46%), Gaps = 9/56 (16%)
Query: 1192 QTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDNTLGVDCIEQ 1246
Q R G L QC + +C NGG C A+P G TCRCP G C +Q
Sbjct: 4223 QPRYTGDKCELDQCWE---HC--RNGGT---CAASPSGMPTCRCPTGFTGPKCTQQ 4270
Score = 30.8 bits (68), Expect = 8.4
Identities = 27/100 (27%), Positives = 35/100 (35%), Gaps = 7/100 (7%)
Query: 664 SPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRT-CYDIDECSEQPSVC 721
S D C C A C + + C C GF G+ C DI+EC C
Sbjct: 3777 SIDPKLTSCATNASICGDEARCVRTEKAAY-CACRSGFHTVPGQPGCQDINECLRF-GTC 3834
Query: 722 GSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINY 761
+CNN G C C + TC A + + Y
Sbjct: 3835 SQ--LCNNTKGGHLCSCARNF-MKTHNTCKAEGSEYQVLY 3871
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 164 bits (415), Expect = 5e-40
Identities = 128/469 (27%), Positives = 205/469 (43%), Gaps = 55/469 (11%)
Query: 784 SYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRC 839
S+ C C G+ S D + C+DV+EC C NTPGS+ C C G+ DG RC
Sbjct: 336 SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Query: 840 ---VPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYC 896
V + C H+ +L + G P F PE GS
Sbjct: 396 HQLVSCPRNVSECSHDC--VLTSEG---------PLCFCPE-------------GSV--- 428
Query: 897 WCVDRDGREVEGTRT--RPGMTPPCLSTVAPPIHQGPAVPTAVIPLP--------PGTHL 946
++RDG+ G + G + C+ ++P + P + L P L
Sbjct: 429 --LERDGKTCSGCSSPDNGGCSQLCVP-LSPVSWECDCFPGYDLQLDEKSCAASGPQPFL 485
Query: 947 LFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRAS 1006
LFA + I + +G T+ L ++ L D V+ +Y+ I RA+
Sbjct: 486 LFANSQDIRHMHFDG-----TDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN 540
Query: 1007 LHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
+ G + +I + + PEG+AVD +GR +WTD I + L+G + +++ + ++ P
Sbjct: 541 MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP 600
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWV 1126
RGI + L+WTD NP+IE+S + G R ++ DL P+G+T D + +L W
Sbjct: 601 RGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWC 659
Query: 1127 DAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETD 1185
DA + E N RR+ + + +PFAV + ++F+DW M SV+ ++ K+
Sbjct: 660 DAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRV 719
Query: 1186 AFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
Q + + G + C NGGC H+C G+ C C
Sbjct: 720 RLQ-GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Score = 78.6 bits (192), Expect = 4e-14
Identities = 68/234 (29%), Positives = 89/234 (38%), Gaps = 61/234 (26%)
Query: 712 DECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCD 770
D C Q C IC GT C C EG+ + +G TC+A+ + + E L N
Sbjct: 743 DPCLYQNGGC--EHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV 800
Query: 771 IP---------------------------------------QRAQCIYTGGSSYTCSCLP 791
P A+CI + G TC CL
Sbjct: 801 TPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCI-SEGEDATCQCLK 859
Query: 792 GFSGDGQACQDVDECQPS--RCHP-DAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTR 848
GF+GDG+ C D+DEC+ C P + C NT G + C+C GYQGDG C ++
Sbjct: 860 GFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHC----LDIDE 915
Query: 849 CQHEREHILGA-AGATDPQ---------RPIPPGLFVPECDAHGHYAPTQCHGS 892
CQ EH G A T+ + R PGL P+ H H S
Sbjct: 916 CQ-LGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYS 968
Score = 76.6 bits (187), Expect = 1e-13
Identities = 104/410 (25%), Positives = 153/410 (37%), Gaps = 67/410 (16%)
Query: 695 CECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVA 752
C C+ G+ D + C D++EC+ C C N PG++ C C G+ +G
Sbjct: 339 CMCAEGYALSRDRKYCEDVNECAFWNHGCTLG--CKNTPGSYYCTCPVGFVLLPDGKRCH 396
Query: 753 VVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPG--FSGDGQACQDVDECQPSR 810
+ P N E H+C + C C G DG+ C
Sbjct: 397 QLVSCPRNVSECS-HDCVLTSEGP---------LCFCPEGSVLERDGKTCSGCSSPDNGG 446
Query: 811 CHPDAFCYN-TPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPI 869
C C +P S+ C C PGY ++++ C A+ PQ
Sbjct: 447 C--SQLCVPLSPVSWECDCFPGYD--------LQLDEKSC-----------AASGPQ--- 482
Query: 870 PPGLFVPECD-AHGHYAPTQ----CHGSTGYCWCVDRDGRE--VEGTRT------RPGMT 916
P LF D H H+ T G + +D D E + T R M
Sbjct: 483 PFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMD 542
Query: 917 PPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGK--IERLPLEGNTMRKTEAKAFLH 974
S I +G VP + G + GK I R L G K K +
Sbjct: 543 G---SQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK-RSKIITKENIS 598
Query: 975 VPAKVIIGLAFDCVDKMVYWTDI-TEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGR 1033
P G+A + K ++WTD P I +SL G I DL P GI +D L
Sbjct: 599 QPR----GIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTD 654
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDW 1083
++W D+ IE+A LDG++RR L + D+ +P + ++++DW
Sbjct: 655 KLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAV--FEDYVWFSDW 702
Score = 76.6 bits (187), Expect = 1e-13
Identities = 61/187 (32%), Positives = 74/187 (39%), Gaps = 38/187 (20%)
Query: 678 GCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC-GSHTICNNHPGTFRC 736
GC A C TC+C GF GDG+ C DIDEC VC + + C N G + C
Sbjct: 839 GCSMYARCI-SEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
Query: 737 ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD 796
C EGYQ G + +D I+ C+ G H+C + A C T G YTC C S
Sbjct: 898 RCSEGYQ----GDGIHCLD---IDECQLGEHSCG--ENASCTNTEG-GYTCMCAGRLSEP 947
Query: 797 GQACQDV-------------------DECQPSR---CHPDAFC--YNTPGSFTCQCKPGY 832
G C D EC S C D C + C C GY
Sbjct: 948 GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
Query: 833 QGDGFRC 839
G+ RC
Sbjct: 1008 IGE--RC 1012
Score = 68.9 bits (167), Expect = 3e-11
Identities = 70/351 (19%), Positives = 136/351 (38%), Gaps = 68/351 (19%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F+ I R+ EG + L V A V + + F +K +YW D+
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQ------LVVDAGVSVIMDFHYNEKRIYWVDLERQL 97
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
+ R L+G + + + G+A++ + + W++ I V + G +L
Sbjct: 98 LQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA 156
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121
L P + D V ++W+ + + + +DG + L++ + ++ D
Sbjct: 157 -LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDK 212
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYP-----FAVTSYGKNLYFTDWKMNSV--- 1173
+L W+ + L S ++ ++P FA++ +G ++++ WKM ++
Sbjct: 213 RLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
Query: 1174 --------VALDLAIS-----------------KETDAFQPHKQ----------TRLYG- 1197
V ++L S E D ++P ++ + + G
Sbjct: 273 NKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQ 332
Query: 1198 -ITTALSQCPQGH------------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
+ + L C +G+ N C+ N GCT C TPGS C CP
Sbjct: 333 DLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCP 383
Score = 58.2 bits (139), Expect = 5e-08
Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 20/141 (14%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP 731
C +G C ++ + C CS G++GDG C DIDEC CG + C N
Sbjct: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTE 933
Query: 732 GTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHN---------CDIPQRAQCIYTGG 782
G + C C + S+ G + D P + H+ C + C++ G
Sbjct: 934 GGYTCMCAG--RLSEPG--LICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGV 989
Query: 783 -------SSYTCSCLPGFSGD 796
Y C+C+ G+ G+
Sbjct: 990 CMYIEALDKYACNCVVGYIGE 1010
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/131 (26%), Positives = 44/131 (33%), Gaps = 28/131 (21%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTIC 727
N C HGC PG + C C +GF DG+ C+ + C S C SH
Sbjct: 358 NECAFWNHGCTLGCKNTPG---SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCV 413
Query: 728 NNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRA----QCIYTGG 782
G C C EG +G TC C P C+
Sbjct: 414 LTSEGPL-CFCPEGSVLERDGKTC----------------SGCSSPDNGGCSQLCVPLSP 456
Query: 783 SSYTCSCLPGF 793
S+ C C PG+
Sbjct: 457 VSWECDCFPGY 467
Score = 30.8 bits (68), Expect = 8.4
Identities = 10/29 (34%), Positives = 16/29 (55%)
Query: 397 CSVHAECRDYATGFCCSCVAGYTGNGRQC 425
CS++A C C C+ G+ G+G+ C
Sbjct: 840 CSMYARCISEGEDATCQCLKGFAGDGKLC 868
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 154 bits (388), Expect = 7e-37
Identities = 155/604 (25%), Positives = 231/604 (38%), Gaps = 128/604 (21%)
Query: 676 THGCDTNAAC--RPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGT 733
T G D N C R +FTC + C + C H C ++
Sbjct: 2979 TDGYDENQNCTRRTCSENEFTCGYGL--------------CIPKIFRCDRHNDCGDYSDE 3024
Query: 734 FRC---ECVEGYQFSDEGTCVA---VVDQRPINYCETG----LHNCDIPQ---------- 773
C C + G C++ V D+ N C G +H C P+
Sbjct: 3025 RGCLYQTCQQNQFTCQNGRCISKTFVCDED--NDCGDGSDELMHLCHTPEPTCPPHEFKC 3082
Query: 774 -RAQCIYTGG-SSYTCSCLPGFSGDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
+CI ++ CL + D + C ++EC PS D C +T SF C C+P
Sbjct: 3083 DNGRCIEMMKLCNHLDDCLD--NSDEKGC-GINECHDPSISGCDHNCTDTLTSFYCSCRP 3139
Query: 831 GYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQ 888
GY+ D CV + EC +
Sbjct: 3140 GYKLMSDKRTCVD---------------------------------IDECTEMPFVCSQK 3166
Query: 889 CHGSTG--YCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHL 946
C G C C RE +G R S + P +L
Sbjct: 3167 CENVIGSYICKCAPGYLREPDGKTCRQN------SNIEP-------------------YL 3201
Query: 947 LFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRAS 1006
+F+ + L ++G + + ++ L FD V+K +YW D I R
Sbjct: 3202 IFSNRYYLRNLTIDGYFY------SLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMF 3255
Query: 1007 LHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDL--- 1063
L+ TII L + E +AVD + R ++W D+ LD + V+ L+G RR+L + +
Sbjct: 3256 LNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDAN 3315
Query: 1064 -----VNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDA 1118
NPRG+ G LYW DW I MDGTN+ +++ L PNG+T D
Sbjct: 3316 NTFCFDNPRGLALHPQYGYLYWADWGH-RAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALD 1177
+ L W DA E + R +G L +PFA+T + +Y+TDW +V +
Sbjct: 3375 TNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN 3434
Query: 1178 L--AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCR 1233
+++T H+ ++ + Q P N C NNGGC+HLCL PG + TC
Sbjct: 3435 KYDGSNRQTLVNTTHRPFDIH-VYHPYRQ-PIVSNPCGTNNGGCSHLCLIKPGGKGFTCE 3492
Query: 1234 CPDN 1237
CPD+
Sbjct: 3493 CPDD 3496
Score = 141 bits (356), Expect = 3e-33
Identities = 150/602 (24%), Positives = 239/602 (39%), Gaps = 84/602 (13%)
Query: 678 GCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC- 736
G D N C+ Q TC+ + + + +D C + IC ++ F C
Sbjct: 136 GADEND-CQYPTCEQLTCDNGACYNTSQKCDWKVD-CRDSSDEINCTEICLHNE--FSCG 191
Query: 737 --ECV-EGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS----C 789
EC+ Y + C D+ NY G + P +CIY ++ C C
Sbjct: 192 NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS-GRCIY---QNWVCDGEDDC 247
Query: 790 LPGFSGDGQACQ----DVDECQPSR--CHPDAFCYNT----PGSFTCQCKPGYQGD---- 835
+GD C+ DV +C P C C + G C PG + +
Sbjct: 248 KD--NGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDC---PGREDENNTS 302
Query: 836 -GFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTG 894
G C CQ++ H GA PPG + D+ C G
Sbjct: 303 TGKYCSMTLCSALNCQYQC-HETPYGGACF----CPPGYIINHNDSRTCVEFDDCQ-IWG 356
Query: 895 YC--WCVDRDGREV----EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLF 948
C C R GR + EG G + A I G LL
Sbjct: 357 ICDQKCESRPGRHLCHCEEGYILERGQY----------CKANDSFGEASIIFSNGRDLLI 406
Query: 949 AQT-GKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
G+ R+ +E V +G+AF + V+WTD + + +
Sbjct: 407 GDIHGRSFRILVESQNRG-------------VAVGVAFHYHLQRVFWTDTVQNKVFSVDI 453
Query: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPR 1067
+G ++ + +PE +AVD + I+ ++ ++RI++ LDG+ R L +L +PR
Sbjct: 454 NGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPR 513
Query: 1068 GIVTDSVRGNLYWTDWN--RDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCW 1125
GI D G L+++DW PK+E ++MDG+NR+ LV+ LG P G+T D S ++ W
Sbjct: 514 GIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYW 573
Query: 1126 VDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISK 1182
VD+ + E + R+ + G + +PF V+ + ++FTDW +V+ +
Sbjct: 574 VDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTET 633
Query: 1183 ETDAFQPHKQTRLYGITTALS-QCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGV 1241
+ R YG+T S + P N C NNGGC +C+ + R ++ LG
Sbjct: 634 NPQVYY-QASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSH-----RTDNDGLGF 687
Query: 1242 DC 1243
C
Sbjct: 688 RC 689
Score = 131 bits (330), Expect = 4e-30
Identities = 79/264 (29%), Positives = 138/264 (52%), Gaps = 11/264 (4%)
Query: 980 IIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD 1039
I+ + FD + ++W+D T+ A +G + + + E IA+D +GRN++WTD
Sbjct: 1468 IVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTD 1527
Query: 1040 SNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN--LYWTDWNRDNPKIETSYMDG 1097
L+ IEV+K+DG+ R VL +L NPRG+ D L+W+DW +P+IE + MDG
Sbjct: 1528 YALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
Query: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPF 1154
+ R ++VQD + P GLT D + L ++D+ + + + + RR+ + +++P+
Sbjct: 1587 SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPY 1646
Query: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSV 1214
A+T + ++Y+TD V+ + + Q L + S+ P N C+
Sbjct: 1647 ALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAF 1706
Query: 1215 NNGGCTHLCLAT---PGSRTCRCP 1235
+ C+HLCL + P +C CP
Sbjct: 1707 SR--CSHLCLLSSQGPHFYSCVCP 1728
Score = 130 bits (328), Expect = 6e-30
Identities = 76/264 (28%), Positives = 137/264 (51%), Gaps = 15/264 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+G+ FD D ++++D+++ I + + G + + + E +A D + +N++WTDS
Sbjct: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDS 803
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
+ I V +L RR + + L NPR +V G L++TDW R KI ++ DG++
Sbjct: 804 HYKSISVMRLADKTRRTVVQY-LNNPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGSHL 861
Query: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA--LEGLQYPFAVTS 1158
++ LG PNGL D +S+L WVDA ++ E RR+ +E + +PF +
Sbjct: 862 LPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAI 921
Query: 1159 YGKNLYFTDWKMNSVVAL------DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
+G++L+FTDW++ +++ + ++ + + A+ H ++ I T + C N
Sbjct: 922 FGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNAC----NQP 977
Query: 1213 SVNNGGCTHLCLATPG-SRTCRCP 1235
+ NG C+H C P R C CP
Sbjct: 978 THPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 126 bits (316), Expect = 1e-28
Identities = 81/263 (30%), Positives = 126/263 (47%), Gaps = 8/263 (3%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGR---ASLHGGEPT-TIIRQDLGSPEGIAVDHLGR 1033
+ ++ L +D V +Y+T +G+ A+L G T T+I +G+ +GIA D + R
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
I+++D I DG+ R V+ PR IV D +G LYW DW+ + KIE +
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVIARVP--KPRAIVLDPCQGYLYWADWDT-HAKIERA 2535
Query: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYP 1153
+ G R +V L +P+GLT D L WVDA R E + R + +
Sbjct: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHA 2595
Query: 1154 FAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTAL-SQCPQGHNYC 1212
F +T YG+ +Y+TD + + A + ++ GI T + +Q Q +N C
Sbjct: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
NGGC+H+C P C+CP
Sbjct: 2656 EQFNGGCSHICAPGPNGAECQCP 2678
Score = 124 bits (311), Expect = 6e-28
Identities = 77/224 (34%), Positives = 114/224 (50%), Gaps = 18/224 (8%)
Query: 1023 PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTD 1082
P+GIAVD +GR+I+W+D RIEVAKLDG R+ L TDL P I + G ++WTD
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 1083 WNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS-QLCWVDAGTNRAECLNPSQP 1141
W ++ PKIE+++M+G +R ILV +DLG P GL+ D ++ ++ W D + E +
Sbjct: 4204 WGKE-PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
Query: 1142 SRRKALEGLQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH-KQTR 1194
RR + P+++ + LY+ WK N ++T P Q R
Sbjct: 4263 DRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK---FGQGKKEKTLVVNPWLTQVR 4319
Query: 1195 LYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNT 1238
++ P N C C+HLCL PG +C CP +
Sbjct: 4320 IFHQLRYNKSVP---NLCKQI---CSHLCLLRPGGYSCACPQGS 4357
Score = 110 bits (274), Expect = 1e-23
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 29/281 (10%)
Query: 986 DCVDKMVYWTDIT-----EPSIGRASLHGGEPTTIIRQDLGSP--EGIAVDHLGRNIFWT 1038
D +YW D + + +I R G I+ +G GIAVD + N+++T
Sbjct: 2103 DVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFT 2162
Query: 1039 DSNLDR--IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
++ + IEV +++ T RRVL + + PR IV D L+W D+ + PKIE S++D
Sbjct: 2163 NAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLD 2221
Query: 1097 GTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY--PF 1154
TNR +LV + + P GL D + WVD + + + + G +Y P+
Sbjct: 2222 CTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPY 2281
Query: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR-----LYGIT------TALS 1203
+T + ++ + D + + SKE + +P R L +T S
Sbjct: 2282 GITVFENSIIWVDRNLKKI----FQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
Query: 1204 QCPQGHNYCSVNNGGCTHLCLATPGSRT--CRCPDNTLGVD 1242
+N C NNGGC+HLC A PG T C C TL D
Sbjct: 2338 PAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSD 2378
Score = 85.9 bits (211), Expect = 2e-16
Identities = 73/277 (26%), Positives = 112/277 (40%), Gaps = 22/277 (7%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPE-GIAVDHLGRNIFWTD 1039
+ + FD ++ +YW + I R G T + P +A+D + RN++ T+
Sbjct: 1781 LDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTN 1839
Query: 1040 SNLDRIEVAKLDGT--QRRVLFETD-----LVNPRGIVTDSVRGNLYWTDWNRDN---PK 1089
IEV L G R+ L D + P GI D RG LYW+D D+ K
Sbjct: 1840 PRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAK 1899
Query: 1090 IETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG 1149
I ++ MDGT+ + L +L +T D +L W G E N R +
Sbjct: 1900 IASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQ 1959
Query: 1150 LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQG 1208
L +P+ + + LY+TD + + +D A + + L G+ +
Sbjct: 1960 LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDN-VPNLRGLQVYHRRNAAES 2018
Query: 1209 HNYCSVNNGGCTHLCLATPGSR-TCRC-------PDN 1237
N CS N C +CL PG +C C PDN
Sbjct: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDN 2055
Score = 81.3 bits (199), Expect = 5e-15
Identities = 109/458 (23%), Positives = 167/458 (36%), Gaps = 95/458 (20%)
Query: 680 DTNAACR---PGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
+T CR P P T++ +C G C D D+C + G CN
Sbjct: 3915 ETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELG----CNK------ 3964
Query: 736 CECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG 795
E TC N CE C + CSC GF
Sbjct: 3965 ---------GKERTCAE-------NICEQN-----------CTQLNEGGFICSCTAGFET 3997
Query: 796 ---DGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHE 852
D +C D++EC+ P C NT GS+ C C G+ R PG+ RC
Sbjct: 3998 NVFDRTSCLDINECEQFGTCPQ-HCRNTKGSYECVCADGFTSMSDR--PGK----RC--- 4047
Query: 853 REHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDG--------- 903
AA + P +P + + + + Y VD D
Sbjct: 4048 ------AAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEE-YIQAVDYDWDPKDIGLSV 4100
Query: 904 --REVEGTRTRPGMTP----PCLSTVAPPIHQGPAVPTAVIPLPPG-------THLLFA- 949
V G +R G P + + Q + + P G H+ ++
Sbjct: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
Query: 950 -QTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDI-TEPSIGRASL 1007
+ +IE L+G RK L PA + + +++WTD EP I A +
Sbjct: 4161 VKNKRIEVAKLDGR-YRKWLISTDLDQPAAIAVNPKLG----LMFWTDWGKEPKIESAWM 4215
Query: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRN-IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
+G + ++ +DLG P G+++D+L + I+W+D D IE K DGT RRV+ + + +NP
Sbjct: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAK-EAMNP 4274
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
+ D LYW + + + G + LV
Sbjct: 4275 YSL--DIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/197 (28%), Positives = 75/197 (38%), Gaps = 38/197 (19%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC 721
+G PD L +G D + AC P TC S F D C ++ + C
Sbjct: 1251 DGHPDCL--------YGSDEHNACVPK-----TCPSSY-FHCDNGNCIHRAWLCDRDNDC 1296
Query: 722 GSHTI---CNNHPGTFRCECVEGYQFSDEGTCVAV-VDQRPINYCETGLHNCDIPQRAQC 777
G + C P FRC + +Q CV + V I C G + C
Sbjct: 1297 GDMSDEKDCPTQP--FRCPSWQ-WQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSC 1353
Query: 778 I-YTGGSSYTCS---------CLPGF--SGDGQACQDVDECQP-SRCHPDAFCYNTPGSF 824
+ GG ++ C C GF + D + C+D+DEC C CYN GSF
Sbjct: 1354 SDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC--SQHCYNMRGSF 1411
Query: 825 TCQCKPGY--QGDGFRC 839
C C GY + DG C
Sbjct: 1412 RCSCDTGYMLESDGRTC 1428
Score = 40.0 bits (92), Expect = 0.014
Identities = 78/310 (25%), Positives = 105/310 (33%), Gaps = 90/310 (29%)
Query: 670 NPCYIGTH-GCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPS-VCGSHT 725
N C TH D + C P P Q C C G R + TC + D +E P+ CG +
Sbjct: 972 NACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC-EGDPTNEPPTEQCGLFS 1030
Query: 726 I-CNNH---PGTFRCECVEG-YQFSDE-------------------GTCVAV---VDQRP 758
C N P + C+ V+ + SDE G C+ D+R
Sbjct: 1031 FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKR- 1089
Query: 759 INYCETGL--HNCDIPQRAQCIYTGGSSYTC---SCLP-----------GFSGDGQACQD 802
N C G HNC A C+ T YTC C+ G D + C
Sbjct: 1090 -NDCVDGSDEHNCPTHAPASCLDT---QYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNS 1145
Query: 803 VDECQPSR--------------CHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEV---E 845
+ CQPS+ C D C + GS C F+C G+
Sbjct: 1146 TETCQPSQFNCPNHRCIDLSFVCDGDKDCVD--GSDEVGCVLNCTASQFKCASGDKCIGV 1203
Query: 846 KTRCQHEREHILGAAGATDPQRP-----------IPPGLFVP---ECDAHGHYAPTQCHG 891
RC + + A P RP G+ +P ECD H P +G
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH----PDCLYG 1259
Query: 892 STGYCWCVDR 901
S + CV +
Sbjct: 1260 SDEHNACVPK 1269
Score = 39.3 bits (90), Expect = 0.024
Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 3/113 (2%)
Query: 933 VPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMV 992
+P ++ P +L +A G +R +E + + T + GLA D D V
Sbjct: 2191 MPRHIVVDPKNRYLFWADYG--QRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYV 2248
Query: 993 YWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
YW D + I R ++ GE + +IR P + +I W D NL +I
Sbjct: 2249 YWVDDSLDIIARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKI 2300
Score = 36.6 bits (83), Expect = 0.15
Identities = 48/190 (25%), Positives = 69/190 (36%), Gaps = 36/190 (18%)
Query: 672 CYIGTHGCDTNAACRPGPRT-----------QFTCECSIGFRGDGRTCYDIDECS----E 716
C + CD + C+ G QFTC + C D+C E
Sbjct: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNW-VCDGEDDCKDNGDE 253
Query: 717 QPSVCGSHTICNNHPGTFRC----ECVEGYQFSDEGT-CVAVVDQRPIN---YCETGLHN 768
G H + P + C C+ Y+ D C D+ + YC L +
Sbjct: 254 DGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
Query: 769 CDIPQRAQCIYT--GGSSYTCSCLPGF---SGDGQACQDVDECQP-SRCHPDAFCYNTPG 822
+ + QC T GG+ C C PG+ D + C + D+CQ C D C + PG
Sbjct: 314 A-LNCQYQCHETPYGGA---CFCPPGYIINHNDSRTCVEFDDCQIWGIC--DQKCESRPG 367
Query: 823 SFTCQCKPGY 832
C C+ GY
Sbjct: 368 RHLCHCEEGY 377
Score = 36.6 bits (83), Expect = 0.15
Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 8/46 (17%)
Query: 1198 ITTALSQCPQGH--------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
+ + CP G N CS NGGCTH C+ P C CP
Sbjct: 1331 VCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCP 1376
Score = 32.0 bits (71), Expect = 3.8
Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 25/90 (27%)
Query: 718 PSVCG---SHTICNNHPGTFRCECVEGYQFSDEGT--CVAVVDQRPINYCETGLHNCDIP 772
P++C SH +C PG + C C +G F + T C A + + PIN +P
Sbjct: 4331 PNLCKQICSH-LCLLRPGGYSCACPQGSSFIEGSTTECDAAI-ELPIN----------LP 4378
Query: 773 QRAQCIYTGGSSY-------TCSCLPGFSG 795
+C++ GG+ Y C C G++G
Sbjct: 4379 PPCRCMH-GGNCYFDETDLPKCKCPSGYTG 4407
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 149 bits (376), Expect = 2e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 568
Query: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 569 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 628
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 629 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 682
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
Score = 53.5 bits (127), Expect = 1e-06
Identities = 56/185 (30%), Positives = 73/185 (39%), Gaps = 59/185 (31%)
Query: 681 TNAACRPGPRTQFTC---EC-SIGFRGDG-RTCYD--------IDECSEQPSVCGSHTI- 726
T+A +QF C EC +G+R DG R C D + C CG T
Sbjct: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCV 312
Query: 727 -----CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
CN +C +G SDE C+ + +N C LHN G
Sbjct: 313 LAIKHCNQEQ-----DCPDG---SDEAGCL-----QGLNEC---LHN-----------NG 345
Query: 782 GSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
G S + C+C GF D + C D+DEC+ P C C N G F C+C P
Sbjct: 346 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYP 403
Query: 831 GYQGD 835
GY+ D
Sbjct: 404 GYEMD 408
Score = 38.9 bits (89), Expect = 0.031
Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
C QG N C NNGGC+H+C C CP G ++QK
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 372
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 149 bits (376), Expect = 2e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 321 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 380
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 439
Query: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 440 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 499
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 500 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 553
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 554 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 601
Score = 51.6 bits (122), Expect = 5e-06
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 693 FTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
F C C GF+ D +TC DIDEC + P C IC N+ G F+CEC GY+
Sbjct: 229 FECTCPAGFQLLDQKTCGDIDECKD-PDACSQ--ICVNYKGYFKCECYPGYE 277
Score = 50.4 bits (119), Expect = 1e-05
Identities = 53/194 (27%), Positives = 75/194 (38%), Gaps = 49/194 (25%)
Query: 654 SNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF-RGDGRTCYDID 712
+ + P + S + C + CD C G + C S+G RGD C D
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA-DEAGCATSLGTCRGDEFQCGD-- 179
Query: 713 ECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIP 772
G+ + H + +C +G SDE C+ + +N C LHN
Sbjct: 180 ---------GTCVLAIKHCNQEQ-DCPDG---SDEAGCL-----QGLNEC---LHN---- 214
Query: 773 QRAQCIYTGGSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTP 821
GG S + C+C GF D + C D+DEC+ P C C N
Sbjct: 215 -------NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYK 265
Query: 822 GSFTCQCKPGYQGD 835
G F C+C PGY+ D
Sbjct: 266 GYFKCECYPGYEMD 279
Score = 38.9 bits (89), Expect = 0.031
Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
C QG N C NNGGC+H+C C CP G ++QK
Sbjct: 204 CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 243
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 149 bits (376), Expect = 2e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 280 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 339
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 398
Query: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 399 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 458
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 459 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 512
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 560
Score = 51.6 bits (122), Expect = 5e-06
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 693 FTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
F C C GF+ D +TC DIDEC + P C IC N+ G F+CEC GY+
Sbjct: 188 FECTCPAGFQLLDQKTCGDIDECKD-PDACSQ--ICVNYKGYFKCECYPGYE 236
Score = 48.9 bits (115), Expect = 3e-05
Identities = 47/177 (26%), Positives = 64/177 (36%), Gaps = 25/177 (14%)
Query: 666 DALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCG--S 723
D + C CD + EC G TC C + CG S
Sbjct: 80 DCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTS 138
Query: 724 HTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
H P ++RC+ E C D+ C T L+ C + C +
Sbjct: 139 HKCV---PASWRCD--------GEKDCEGGADEAG---CATWLNEC-LHNNGGCSHICTD 183
Query: 784 ---SYTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
+ C+C GF D + C D+DEC+ P C C N G F C+C PGY+ D
Sbjct: 184 LKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYPGYEMD 238
Score = 34.3 bits (77), Expect = 0.76
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 3/43 (6%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
C N C NNGGC+H+C C CP G ++QK
Sbjct: 163 CATWLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 202
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 149 bits (376), Expect = 2e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 568
Query: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 569 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 628
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 629 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 682
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
Score = 53.5 bits (127), Expect = 1e-06
Identities = 56/185 (30%), Positives = 73/185 (39%), Gaps = 59/185 (31%)
Query: 681 TNAACRPGPRTQFTC---EC-SIGFRGDG-RTCYD--------IDECSEQPSVCGSHTI- 726
T+A +QF C EC +G+R DG R C D + C CG T
Sbjct: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCV 312
Query: 727 -----CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
CN +C +G SDE C+ + +N C LHN G
Sbjct: 313 LAIKHCNQEQ-----DCPDG---SDEAGCL-----QGLNEC---LHN-----------NG 345
Query: 782 GSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
G S + C+C GF D + C D+DEC+ P C C N G F C+C P
Sbjct: 346 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYP 403
Query: 831 GYQGD 835
GY+ D
Sbjct: 404 GYEMD 408
Score = 38.9 bits (89), Expect = 0.031
Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
C QG N C NNGGC+H+C C CP G ++QK
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 372
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 144 bits (363), Expect = 5e-34
Identities = 87/282 (30%), Positives = 144/282 (51%), Gaps = 29/282 (10%)
Query: 980 IIGLAFDCVDKMVYWTDITEPSIGRASL---HG-GEPTTIIRQDLGSPEGIAVDHLGRNI 1035
++ L + +YW+D+++ I L HG T+I +D+ +P+G+AVD + NI
Sbjct: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 1036 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1095
+WTDS L + VA G +R+ LF + PR IV D V G +YWTDW KI+ +
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP-AKIKKGGL 547
Query: 1096 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQY 1152
+G + LV +++ PNG+T D S +L WVD+ + ++ + +R+ LE L +
Sbjct: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 1153 PFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCP 1206
PF++ + +++TD + N + D+ + E + P + +T P
Sbjct: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAE-NLLSPEDMVLFHNLTQ-----P 661
Query: 1207 QGHNYC---SVNNGGCTHLCLATPGSR------TCRCPDNTL 1239
+G N+C +++NGGC +LCL P TC CPD L
Sbjct: 662 RGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGML 703
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/164 (30%), Positives = 68/164 (41%), Gaps = 22/164 (13%)
Query: 683 AACRPGPRTQFTCE---CSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC--- 736
A CRP +F C C G R R YD + S++ C + T+C P F+C
Sbjct: 234 ATCRPD---EFQCSDGNCIHGSRQCDRE-YDCKDMSDEVG-CVNVTLCEG-PNKFKCHSG 287
Query: 737 ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGF 793
EC+ + + PI C G + C + C + Y C C GF
Sbjct: 288 ECITLDKVCNMARDCRDWSDEPIKEC--GTNEC-LDNNGGCSHVCNDLKIGYECLCPDGF 344
Query: 794 SGDGQA-CQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
Q C+D+DECQ P C C N G + CQC+ G+Q D
Sbjct: 345 QLVAQRRCEDIDECQDPDTC--SQLCVNLEGGYKCQCEEGFQLD 386
Score = 35.0 bits (79), Expect = 0.45
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1208 GHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
G N C NNGGC+H+C C CPD
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 137 bits (345), Expect = 6e-32
Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 15/268 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHG--GEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
+ L D + ++W D+++ +I AS+ G +I ++ +P IAVD + + I+WT
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI-DNVYNPAAIAVDWVYKTIYWT 530
Query: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
D+ I VA LDGT+R+ LF +DL P I D + G +YW+DW + KIE + M+G
Sbjct: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGF 589
Query: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRR---KALEGLQYPFA 1155
+RR LV D+ PNG+T D S+L W+D+ + ++ + RR K+LE L +P A
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
Query: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC--S 1213
+T + +Y+ D + +V + E + I P G N+C
Sbjct: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
Query: 1214 VNNGGCTHLCLATP------GSRTCRCP 1235
+ NGGC +LCL P TC CP
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCP 737
Score = 58.2 bits (139), Expect = 5e-08
Identities = 53/169 (31%), Positives = 66/169 (39%), Gaps = 36/169 (21%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI-CNN-----HPGTFRCEC 738
CRP QF CE G R C I +C V GS + C N PG F+C
Sbjct: 278 CRPD---QFECEDGSCIHGS-RQCNGIRDC-----VDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS----------SYTCS 788
E S V +Q ++ + L C I + C+ G Y C
Sbjct: 329 GECIDISK----VCNQEQDCRDWSDEPLKECHINE---CLVNNGGCSHICKDLVIGYECD 381
Query: 789 CLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
C GF D + C D+DECQ P C C N G + C+C GYQ D
Sbjct: 382 CAAGFELIDRKTCGDIDECQNPGIC--SQICINLKGGYKCECSRGYQMD 428
Score = 55.5 bits (132), Expect = 3e-07
Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)
Query: 963 TMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-IGRASLHGGEPTTIIRQDLG 1021
T RK + L PA + A D + VYW+D EP+ I +A ++G + ++ D+
Sbjct: 545 TKRKFLFNSDLREPASI----AVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
Query: 1022 SPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWT 1081
P GI +D + ++W DS L + L+G RR++ ++ + +YW
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
Query: 1082 D 1082
D
Sbjct: 661 D 661
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/86 (38%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICN 728
N C + GC + C+ + C+C+ GF D +TC DIDEC + P +C IC
Sbjct: 358 NECLVNNGGC--SHICKDLV-IGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ--ICI 411
Query: 729 NHPGTFRCECVEGYQFS-DEGTCVAV 753
N G ++CEC GYQ G C AV
Sbjct: 412 NLKGGYKCECSRGYQMDLATGVCKAV 437
Score = 32.7 bits (73), Expect = 2.2
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 1210 NYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
N C VNNGGC+H+C C C G + I++K
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDC---AAGFELIDRK 392
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 137 bits (345), Expect = 6e-32
Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 15/268 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHG--GEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
+ L D + ++W D+++ +I AS+ G +I ++ +P IAVD + + I+WT
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI-DNVYNPAAIAVDWVYKTIYWT 530
Query: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
D+ I VA LDGT+R+ LF +DL P I D + G +YW+DW + KIE + M+G
Sbjct: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGF 589
Query: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRR---KALEGLQYPFA 1155
+RR LV D+ PNG+T D S+L W+D+ + ++ + RR K+LE L +P A
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
Query: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC--S 1213
+T + +Y+ D + +V + E + I P G N+C
Sbjct: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
Query: 1214 VNNGGCTHLCLATP------GSRTCRCP 1235
+ NGGC +LCL P TC CP
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCP 737
Score = 58.2 bits (139), Expect = 5e-08
Identities = 53/169 (31%), Positives = 66/169 (39%), Gaps = 36/169 (21%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI-CNN-----HPGTFRCEC 738
CRP QF CE G R C I +C V GS + C N PG F+C
Sbjct: 278 CRPD---QFECEDGSCIHGS-RQCNGIRDC-----VDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS----------SYTCS 788
E S V +Q ++ + L C I + C+ G Y C
Sbjct: 329 GECIDISK----VCNQEQDCRDWSDEPLKECHINE---CLVNNGGCSHICKDLVIGYECD 381
Query: 789 CLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
C GF D + C D+DECQ P C C N G + C+C GYQ D
Sbjct: 382 CAAGFELIDRKTCGDIDECQNPGIC--SQICINLKGGYKCECSRGYQMD 428
Score = 55.5 bits (132), Expect = 3e-07
Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)
Query: 963 TMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-IGRASLHGGEPTTIIRQDLG 1021
T RK + L PA + A D + VYW+D EP+ I +A ++G + ++ D+
Sbjct: 545 TKRKFLFNSDLREPASI----AVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
Query: 1022 SPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWT 1081
P GI +D + ++W DS L + L+G RR++ ++ + +YW
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
Query: 1082 D 1082
D
Sbjct: 661 D 661
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/86 (38%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICN 728
N C + GC + C+ + C+C+ GF D +TC DIDEC + P +C IC
Sbjct: 358 NECLVNNGGC--SHICKDLV-IGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ--ICI 411
Query: 729 NHPGTFRCECVEGYQFS-DEGTCVAV 753
N G ++CEC GYQ G C AV
Sbjct: 412 NLKGGYKCECSRGYQMDLATGVCKAV 437
Score = 32.7 bits (73), Expect = 2.2
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 1210 NYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
N C VNNGGC+H+C C C G + I++K
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDC---AAGFELIDRK 392
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 137 bits (344), Expect = 8e-32
Identities = 133/516 (25%), Positives = 210/516 (40%), Gaps = 72/516 (13%)
Query: 429 GSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLA 488
G PQR G V G I + I F N + + I+ +P ++G ++ +
Sbjct: 4870 GGPQRARGSVIGNI--NDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRKIV 4927
Query: 489 PVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFS-GIDEHGHLT 547
+ I W A E NGF++T F R+ +V F G ++ + G+D G L
Sbjct: 4928 SILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFA--TGEILQMSHIARGLDSDGSLL 4985
Query: 548 IDTELEGRVPQIPFGSSVHIEPYTELY-HYSTSVITSSSTREYTVTEPERDGASPSRIYT 606
+D + G V Q+ + V ++ YTE Y + + STR +T+ DG S
Sbjct: 4986 LDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTI-----DGIS----IP 5036
Query: 607 YQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALS------------ 654
Y W T+ + + P L T L SV YNQ E+ L + +
Sbjct: 5037 YTWNHTVFYDQA--QGRMPFLVET--LHASSVESDYNQIEETLGFKIHASISKGDRSNQC 5092
Query: 655 ------NSIGPVREGSPD-ALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRT 707
+S+GP + A NPC H C +C + DGRT
Sbjct: 5093 PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYC--------SCPKGLTIAADGRT 5144
Query: 708 CYDIDECSEQPSVCGSHTICNNHPGTFRC--ECVEGYQFSDEGTCVAVVDQRPINYCETG 765
C DIDEC+ C + C+N G++RC C G++ + +G + + IN C+
Sbjct: 5145 CQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDG-----LSCQDINECQES 5199
Query: 766 LHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFT 825
P +C GS + C C PG+ G+ C DV+EC+ + C PD C NT G +
Sbjct: 5200 S-----PCHQRCFNAIGS-FHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYK 5253
Query: 826 C--QCKPGY-QGDGFRCVPGEVEKT---RCQHER--EHILGAAGATDP-----QRPIPPG 872
C C G + + C+ + K +C++ + E+ G+ P Q P
Sbjct: 5254 CIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPC 5313
Query: 873 LFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEG 908
+ + EC+ QC + G C+ G+ + G
Sbjct: 5314 MDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLG 5349
Score = 84.0 bits (206), Expect = 8e-16
Identities = 61/193 (31%), Positives = 81/193 (41%), Gaps = 37/193 (19%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNN 729
C GTH C N C R + C C G+R G GR C DI+EC + P C C+N
Sbjct: 5276 CKDGTHQCRYNQICE-NTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSN 5332
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCE----------TGLHNCDIPQ----RA 775
PG+F+C C G +G A +++ P NY + + N PQ +
Sbjct: 5333 TPGSFKCICPPGQHLLGDGKSCAGLERLP-NYGTQYSSYNLARFSPVRNNYQPQQHYRQY 5391
Query: 776 QCIYTGGSSYTCS--------------CLPGFSGDGQACQDVDECQ-PSRCHPDAFCYNT 820
+Y+ S Y S C G C D+DEC+ C + C NT
Sbjct: 5392 SHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHE--CKNT 5449
Query: 821 PGSFTCQCKPGYQ 833
GS+ C C PGYQ
Sbjct: 5450 FGSYQCICPPGYQ 5462
Score = 64.7 bits (156), Expect = 5e-10
Identities = 51/136 (37%), Positives = 66/136 (48%), Gaps = 26/136 (19%)
Query: 723 SHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGG 782
S T + T R C EG + S + TCV I+ CE N D Q +C T G
Sbjct: 5404 SRTSLSRTRRTIRKTCPEGSEASHD-TCV------DIDECE----NTDACQH-ECKNTFG 5451
Query: 783 SSYTCSCLPGF--SGDGQACQDVDEC--QPSRCHPDAFCYNTPGSFTC---QCKPGYQGD 835
S Y C C PG+ + +G+ CQD+DEC Q C P+ C+N GS+ C C P YQ D
Sbjct: 5452 S-YQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRD 5510
Query: 836 ---GF---RCVPGEVE 845
GF C P ++E
Sbjct: 5511 PVSGFCLKNCPPNDLE 5526
Score = 50.1 bits (118), Expect = 1e-05
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 12/105 (11%)
Query: 650 RYALSNSIGPVREGSPD---ALQNPCYIGTHGCDTNAACRPGPRTQF---TCECSIGFR- 702
R +LS + +R+ P+ A + C + C+ AC+ + F C C G++
Sbjct: 5405 RTSLSRTRRTIRKTCPEGSEASHDTC-VDIDECENTDACQHECKNTFGSYQCICPPGYQL 5463
Query: 703 -GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC---ECVEGYQ 743
+G+TC DIDEC EQ CG + +C N G+++C C YQ
Sbjct: 5464 THNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQ 5508
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 132 bits (332), Expect = 2e-30
Identities = 81/222 (36%), Positives = 100/222 (45%), Gaps = 50/222 (22%)
Query: 659 PVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSE 716
P R+G D N C + GCD + G + C C G+ DGR C D+DEC E
Sbjct: 1148 PDRQGCVDI--NECRVQNGGCDVHCINTEG---SYRCSCGQGYSLMPDGRACADVDECEE 1202
Query: 717 QPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCVAV--VDQRP--------------- 758
P VC C N PG RC C +G+ + D TCV V D P
Sbjct: 1203 NPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSF 1261
Query: 759 -------------------INYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQA 799
++ CE G HNCD A C+ GS ++C CLPG+ GDG
Sbjct: 1262 VCHCQLGYMVRKGATGCSDVDECEVGGHNCD--SHASCLNIPGS-FSCRCLPGWVGDGFE 1318
Query: 800 CQDVDEC--QPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
C D+DEC Q RC P C N PGS+ C C+ G+ GDGF C
Sbjct: 1319 CHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC 1360
Score = 117 bits (292), Expect = 9e-26
Identities = 69/183 (37%), Positives = 90/183 (49%), Gaps = 22/183 (12%)
Query: 693 FTCECSIGFRGDGR--TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-T 749
F C C G+ D TC D+DECS+ P C +C N G+F C C GY ++G T
Sbjct: 2386 FRCHCQAGYTPDATATTCLDMDECSQVPKPCTF--LCKNTKGSFLCSCPRGYLLEEDGRT 2443
Query: 750 CVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC--Q 807
C + ++ C + HNC C+ T G+ +TC C PGF+ QAC D DEC Q
Sbjct: 2444 C------KDLDECTSRQHNCQF----LCVNTVGA-FTCRCPPGFTQHHQACFDNDECSAQ 2492
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGY----QGDGFRCVPGEVEKTRCQHEREHILGAAGAT 863
P C C+NTPGSF C+C G+ G G V RCQH ++ LG +
Sbjct: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCS 2552
Query: 864 DPQ 866
PQ
Sbjct: 2553 CPQ 2555
Score = 112 bits (280), Expect = 2e-24
Identities = 66/182 (36%), Positives = 89/182 (48%), Gaps = 21/182 (11%)
Query: 660 VREGSPDALQ-NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQP 718
VR+G+ + C +G H CD++A+C P + F+C C G+ GDG C+D+DEC Q
Sbjct: 1271 VRKGATGCSDVDECEVGGHNCDSHASCLNIPGS-FSCRCLPGWVGDGFECHDLDECVSQE 1329
Query: 719 SVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETG---LHNCDIPQRA 775
C C N PG++RC C +G F+ +G +CE N D+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQG--FAGDGF-----------FCEDRDECAENVDLCDNG 1376
Query: 776 QCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ 833
QC+ G Y C C GF + D +ACQDVDEC C N PG F C C GY+
Sbjct: 1377 QCLNAPG-GYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYE 1435
Query: 834 GD 835
D
Sbjct: 1436 LD 1437
Score = 104 bits (259), Expect = 6e-22
Identities = 69/185 (37%), Positives = 83/185 (44%), Gaps = 36/185 (19%)
Query: 693 FTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-TCV 751
FTC C GF + C+D DECS QP CG+H C+N PG+FRCEC +G+ G C
Sbjct: 2468 FTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
Query: 752 AVVDQRPINYCETGLHN------CDIPQR-------AQCI---------YTGGSS----- 784
V + + C+ G N C PQ AQC+ T GS+
Sbjct: 2528 DVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNT 2587
Query: 785 ---YTCSCLPGFSGDGQ--ACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY--QGDGF 837
+ C C GF D CQ+VDEC R C NTPG F C C GY G G
Sbjct: 2588 LGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG- 2646
Query: 838 RCVPG 842
CV G
Sbjct: 2647 HCVSG 2651
Score = 98.2 bits (243), Expect = 4e-20
Identities = 56/145 (38%), Positives = 70/145 (48%), Gaps = 17/145 (11%)
Query: 693 FTCECSIGFRGDG--RTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
F CEC GF + C D+DEC + S C + C N PG++RC+C GY+ S G C
Sbjct: 1744 FRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC 1803
Query: 751 VAVVDQRPI-NYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQ 807
V + R I N C G C+ T G SY C C GF S D C D+DEC
Sbjct: 1804 VGRNECREIPNVCSHG----------DCMDTEG-SYMCLCHRGFQASADQTLCMDIDECD 1852
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGY 832
C + C N GS+ C C PG+
Sbjct: 1853 RQPC-GNGTCKNIIGSYNCLCFPGF 1876
Score = 96.7 bits (239), Expect = 1e-19
Identities = 64/186 (34%), Positives = 87/186 (46%), Gaps = 25/186 (13%)
Query: 656 SIGPVREGSPDALQNP----CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGR-TCYD 710
S+GP A N C T+ C N C P P + + CEC++G+ D R C D
Sbjct: 392 SLGPGNSNIGTATLNQTIDICRHFTNLC-LNGRCLPTP-SSYRCECNVGYTQDVRGECID 449
Query: 711 IDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPIN--YCETGLHN 768
+DEC+ P H C N PGT+ C C G+Q + VD+ ++ C G
Sbjct: 450 VDECTSSPC---HHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLG--- 503
Query: 769 CDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTC 826
+C+ T GS + C C GF S DG+ C D +EC S + C N GSF+C
Sbjct: 504 -------RCVNTEGS-FQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSC 555
Query: 827 QCKPGY 832
CKPG+
Sbjct: 556 LCKPGF 561
Score = 92.0 bits (227), Expect = 3e-18
Identities = 75/251 (29%), Positives = 102/251 (40%), Gaps = 48/251 (19%)
Query: 693 FTCECSIGFRGDG---RTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGT 749
F CEC G+ + C D+DEC+ P +C T C N G+++C+C G++ + +GT
Sbjct: 1051 FECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT-CTNTDGSYKCQCPPGHELTAKGT 1109
Query: 750 CVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG--DGQACQDVDECQ 807
+D+ C C QC+ G ++ CSC GF D Q C D++EC+
Sbjct: 1110 ACEDIDE-----CSLSDGLC---PHGQCVNVIG-AFQCSCHAGFQSTPDRQGCVDINECR 1160
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRCVP-GEVEKTRCQHEREHILGAAG--- 861
D C NT GS+ C C GY DG C E E+ ++ H G
Sbjct: 1161 VQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHR 1220
Query: 862 --------ATDPQRPIPPGLFVPECD------AHGHYAPTQ----CHGSTGY------CW 897
AT R + V ECD HG T+ CH GY
Sbjct: 1221 CLCYDGFMATPDMRTC---VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATG 1277
Query: 898 CVDRDGREVEG 908
C D D EV G
Sbjct: 1278 CSDVDECEVGG 1288
Score = 90.5 bits (223), Expect = 9e-18
Identities = 59/170 (34%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 674 IGTHGCDTNAACRPGPRTQ----FTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICN 728
+ T C C G T F C C+ GF G TC DIDECS P +C C+
Sbjct: 2125 VDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFR--CH 2182
Query: 729 NHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS 788
N G++ C C GY ++G VD+ C G +C + +C G ++ C
Sbjct: 2183 NTEGSYLCTCPAGYTLREDGAMCRDVDE-----CADGQQDCH-ARGMECKNLIG-TFACV 2235
Query: 789 CLPG---FSGDGQACQDVDEC--QPSRCHPDAFCYNTPGSFTCQCKPGYQ 833
C PG G G+ C D +EC QP C + C NT GSF C C G+Q
Sbjct: 2236 CPPGMRPLPGSGEGCTDDNECHAQPDLC-VNGRCVNTAGSFRCDCDEGFQ 2284
Score = 84.3 bits (207), Expect = 6e-16
Identities = 64/200 (32%), Positives = 86/200 (43%), Gaps = 29/200 (14%)
Query: 693 FTCECSIGFRG--DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
+ C C GF+ D C DIDEC QP CG+ T C N G++ C C G+ + G C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDECDRQP--CGNGT-CKNIIGSYNCLCFPGFVVTHNGDC 1884
Query: 751 VAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQP 808
V + C T + + + C+ T GS + C C GF + DG+ C D +EC
Sbjct: 1885 V------DFDECTTLVGQ--VCRFGHCLNTAGS-FHCLCQDGFELTADGKNCVDTNECLS 1935
Query: 809 --SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDP- 865
C P C N GSF C C PG+Q C ++ C E L P
Sbjct: 1936 LAGTCLPGT-CQNLEGSFRCICPPGFQVQSDHC----IDIDECSEEPNLCLFGTCTNSPG 1990
Query: 866 --QRPIPPGLFVPECDAHGH 883
Q PPG + + +GH
Sbjct: 1991 SFQCLCPPGFVLSD---NGH 2007
Score = 82.8 bits (203), Expect = 2e-15
Identities = 62/199 (31%), Positives = 91/199 (45%), Gaps = 36/199 (18%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNN 729
C + + CD N C+ P + ++C C GF D C D+DEC P V G +C N
Sbjct: 728 CALNSLLCD-NGWCQNSPGS-YSCSCPPGFHFWQDTEICKDVDECLSSPCVSG---VCRN 782
Query: 730 HPGTFRCECVEGYQF---------SDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
G++ C+C G + S +GTC + + + CE L + R++C T
Sbjct: 783 LAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQE---SRCEVNLQGASL--RSECCAT 837
Query: 781 GGSSYTC---------SCLPGFSG-DGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQC 828
G+++ +C GF+ G C DV+EC+ P C P+ C NT GSF C+C
Sbjct: 838 LGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVC-PNGRCVNTAGSFRCEC 896
Query: 829 KPGYQGD--GFRCVPGEVE 845
G D G CV +E
Sbjct: 897 PEGLMLDASGRLCVDVRLE 915
Score = 80.9 bits (198), Expect = 7e-15
Identities = 77/273 (28%), Positives = 105/273 (38%), Gaps = 55/273 (20%)
Query: 675 GTHGCDTN------AACRPGP----RTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
G + DTN C PG F C C GF+ C DIDECSE+P++C
Sbjct: 1924 GKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFG 1983
Query: 725 TICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLH--NCDIPQRAQ------ 776
T C N PG+F+C C G+ SD G D R ++C T C +P+
Sbjct: 1984 T-CTNSPGSFQCLCPPGFVLSDNGH--RCFDTRQ-SFCFTRFEAGKCSVPKAFNTTKTRC 2039
Query: 777 ----------------CIYTGGSSYTCSCLPGFS---GDGQACQDVDEC--QPSRCHPDA 815
C G +++ C G G + +DV+EC P C +
Sbjct: 2040 CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC-TNG 2098
Query: 816 FCYNTPGSFTCQCKPGYQGD--GFRCVPGE---VEKTRCQHEREHILGAAGATDPQRPIP 870
C NT GSF C+C GY D G CV + V Q +++G
Sbjct: 2099 VCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACAD-GFE 2157
Query: 871 PGLF-----VPECDAHGHYAPTQCHGSTGYCWC 898
PGL + EC + +CH + G C
Sbjct: 2158 PGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLC 2190
Score = 80.5 bits (197), Expect = 9e-15
Identities = 62/211 (29%), Positives = 86/211 (40%), Gaps = 47/211 (22%)
Query: 695 CECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVV 754
C G+ +GR D+DEC +C +H C N G+FRC C GY + + T +
Sbjct: 2351 CPHGSGYTAEGR---DVDECRMLAHLC-AHGECINSLGSFRCHCQAGY--TPDATATTCL 2404
Query: 755 DQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQPSRCH 812
D ++ C C C T GS + CSC G+ DG+ C+D+DEC + +
Sbjct: 2405 D---MDECSQVPKPCTF----LCKNTKGS-FLCSCPRGYLLEEDGRTCKDLDECTSRQHN 2456
Query: 813 PDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPG 872
C NT G+FTC+C PG+ C + C + PG
Sbjct: 2457 CQFLCVNTVGAFTCRCPPGFTQHHQAC----FDNDECSAQ------------------PG 2494
Query: 873 LFVPECDAHGHYAPTQCHGSTGYCWCVDRDG 903
C AHGH CH + G C G
Sbjct: 2495 ----PCGAHGH-----CHNTPGSFRCECHQG 2516
Score = 76.3 bits (186), Expect = 2e-13
Identities = 49/128 (38%), Positives = 64/128 (50%), Gaps = 15/128 (11%)
Query: 710 DIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNC 769
DIDEC E P++C ++ IC N G+FRCEC G+ ++ VD E G
Sbjct: 1721 DIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYNSILLACEDVD-------ECGSRES 1772
Query: 770 DIPQRAQCIYTGGSSYTCSCLPGFS-GDGQACQDVDECQ--PSRC-HPDAFCYNTPGSFT 825
Q A CI G SY C C G+ G AC +EC+ P+ C H D C +T GS+
Sbjct: 1773 PCQQNADCINIPG-SYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD--CMDTEGSYM 1829
Query: 826 CQCKPGYQ 833
C C G+Q
Sbjct: 1830 CLCHRGFQ 1837
Score = 64.3 bits (155), Expect = 7e-10
Identities = 63/227 (27%), Positives = 82/227 (36%), Gaps = 78/227 (34%)
Query: 679 CDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC 736
CD N C P + CEC +GF D R C D+DEC+ Q ++C + C N PG FRC
Sbjct: 1373 CD-NGQCLNAPGG-YRCECEMGFDPTEDHRACQDVDECA-QGNLCAFGS-CENLPGMFRC 1428
Query: 737 ECVEGYQFS-DEGTCVAVVD-QRPINYCE------TGLHNCDIPQRAQ-------CIYT- 780
C GY+ G C + + P+N G + C PQ + C+ T
Sbjct: 1429 ICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTR 1488
Query: 781 -----------GGSSYTCSCLPGFSGDGQAC----------------------------- 800
G S +CS G +C
Sbjct: 1489 AGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPG 1548
Query: 801 -------------QDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGY 832
+D+DECQ P C C NT GSF C+C PGY
Sbjct: 1549 GEGFQPNRITVILEDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGY 1594
Score = 63.5 bits (153), Expect = 1e-09
Identities = 57/214 (26%), Positives = 79/214 (36%), Gaps = 75/214 (35%)
Query: 693 FTCECSIGF--RGDGRTCYDIDECSE---------------------------------- 716
+ C C G+ R DG C D+DEC++
Sbjct: 2188 YLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSG 2247
Query: 717 -----------QPSVCGSHTICNNHPGTFRCECVEGYQFSD---------EGTCVAVVDQ 756
QP +C + C N G+FRC+C EG+Q S +G C A V Q
Sbjct: 2248 EGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQ 2306
Query: 757 RPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC----LPGFSGDGQAC----------QD 802
C + + + RA+C GG + C LPG S + C +D
Sbjct: 2307 ---TMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRD 2363
Query: 803 VDECQP-SRCHPDAFCYNTPGSFTCQCKPGYQGD 835
VDEC+ + C N+ GSF C C+ GY D
Sbjct: 2364 VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPD 2397
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/193 (28%), Positives = 72/193 (37%), Gaps = 39/193 (20%)
Query: 693 FTCECSIGFRGD--GRTCYDI-----------DECSEQPSVCGSHTICNNHPGTF---RC 736
F CEC G D GR C D+ DEC +C G C
Sbjct: 892 FRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC 951
Query: 737 E-------------CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
E C G F+ + +N C+ C C T GS
Sbjct: 952 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCT---HGTCRNTVGS 1008
Query: 784 SYTCSCLPGFSGDGQA--CQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
+ C+C GF+ D Q C D+DEC+ P C C NTPGSF C+C PGY+ GF
Sbjct: 1009 -FHCACAGGFALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECFPGYE-SGFML 1065
Query: 840 VPGEVEKTRCQHE 852
+ ++ C +
Sbjct: 1066 MKNCMDVDECARD 1078
Score = 58.9 bits (141), Expect = 3e-08
Identities = 52/187 (27%), Positives = 71/187 (37%), Gaps = 39/187 (20%)
Query: 679 CDTNAACRPG----PRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVC-GSHTICNNHP 731
C T+ C G F+C C GF G C DIDEC + P +C H C N
Sbjct: 535 CATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC-QTPGICVNGH--CTNTE 591
Query: 732 GTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIP-----QRAQCIYTG---GS 783
G+FRC+C+ G +G R Y +C P +++C G
Sbjct: 592 GSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGF 651
Query: 784 SYTCSCLP---------------GFSGDGQACQDVDEC--QPSRCHPDAFCYNTPGSFTC 826
C P G + DG+ D++EC P C + C N GS+ C
Sbjct: 652 GEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVC-ANGVCENLRGSYRC 707
Query: 827 QCKPGYQ 833
C GY+
Sbjct: 708 VCNLGYE 714
Score = 58.2 bits (139), Expect = 5e-08
Identities = 49/169 (28%), Positives = 66/169 (39%), Gaps = 31/169 (18%)
Query: 693 FTCECSIGFRGDGRT--CYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGY-QFSDEGT 749
F CEC G+ T C DIDECS +CG T C N G + C C Y Q +
Sbjct: 1586 FQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYTCVCPAEYLQVNGGNN 1644
Query: 750 CV----AVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC---------------- 789
C+ +V + C+ L + C Y G ++ C
Sbjct: 1645 CMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCG 1704
Query: 790 --LPGFSGDGQACQ--DVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGY 832
PGF D + D+DEC P+ C + C N GSF C+C G+
Sbjct: 1705 NQAPGFLTDIHTGKPLDIDECGEIPAIC-ANGICINQIGSFRCECPAGF 1752
Score = 56.2 bits (134), Expect = 2e-07
Identities = 53/205 (25%), Positives = 72/205 (35%), Gaps = 40/205 (19%)
Query: 669 QNPCYIGTHGCDTNAAC---------RPGPRTQFTCECSIGF-RGDGRTCYDIDECSEQP 718
++ C + G + C P R + C+ GF R G TC D++EC P
Sbjct: 818 ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFP 877
Query: 719 SVCGSHTICNNHPGTFRCECVEGYQFSDEG---------TCVAVVDQRPINYCETGLHNC 769
VC + C N G+FRCEC EG G C D+ G +
Sbjct: 878 GVCPNGR-CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM 936
Query: 770 DI----------PQRAQCIYTGGSSYTCSCLPG-------FSGDGQACQDVDECQ--PSR 810
D+ + C + C G F +DV+EC+ P
Sbjct: 937 DVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
Query: 811 CHPDAFCYNTPGSFTCQCKPGYQGD 835
C C NT GSF C C G+ D
Sbjct: 997 C-THGTCRNTVGSFHCACAGGFALD 1020
Score = 52.8 bits (125), Expect = 2e-06
Identities = 52/184 (28%), Positives = 66/184 (35%), Gaps = 34/184 (18%)
Query: 679 CDTNAACRPGPRTQ----FTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPG 732
C T C G T F C+C G DGR C D S + PG
Sbjct: 576 CQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPG 635
Query: 733 TF---RCECVE-GYQFSD-------------EGTCVA----VVDQRPINYCETGLHNCDI 771
T C C + F + + C + D R IN C C
Sbjct: 636 TVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVC-- 693
Query: 772 PQRAQCIYTGGSSYTCSCLPGFSG--DGQACQDVDECQPSRCHPD-AFCYNTPGSFTCQC 828
C GS Y C C G+ G+ C DVDEC + D +C N+PGS++C C
Sbjct: 694 -ANGVCENLRGS-YRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSC 751
Query: 829 KPGY 832
PG+
Sbjct: 752 PPGF 755
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/247 (27%), Positives = 84/247 (34%), Gaps = 73/247 (29%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI---CNNHP---G 732
C CR +C C G+ G +VCG C+N G
Sbjct: 124 CMNGGTCRGA-----SCLCQKGYTG---------------TVCGQPICDRGCHNGGRCIG 163
Query: 733 TFRCECVEGYQFSD------EGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSY- 785
RC CV G+ G C V + TGL + +A C T G ++
Sbjct: 164 PNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGL----VCTKALCCATVGRAWG 219
Query: 786 -TCSCLP--------GFSGDGQ--ACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGY 832
C P GF + ACQDVDECQ P C + C N GSF C+C G+
Sbjct: 220 LPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGH 278
Query: 833 QGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC--DAHGHYAPTQCH 890
+ C+ R GA + LF C D GHY QC
Sbjct: 279 RLSD--------SSAACEDYRA---GACFSV---------LFGGRCAGDLAGHYTRRQCC 318
Query: 891 GSTGYCW 897
G CW
Sbjct: 319 CDRGRCW 325
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/200 (26%), Positives = 71/200 (35%), Gaps = 50/200 (25%)
Query: 657 IGPVREGSPDALQNPCYIGTH-----GCDTNAACRPGPRTQFTCECSIGFRGDGRTCY-- 709
+ P G D C++ TH G +A G T+ +C CS+G R G C
Sbjct: 1477 LNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGV-TRASCCCSLG-RAWGNPCELC 1534
Query: 710 ----------------------------DIDECSEQPSVCGSHTICNNHPGTFRCECVEG 741
DIDEC E P +C C N G+F+CEC G
Sbjct: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD-CVNTFGSFQCECPPG 1593
Query: 742 YQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQA 799
Y S+ +D+ C T C C T G +YTC C + G
Sbjct: 1594 YHLSEHTRICEDIDE-----CSTHSGICG---PGTCYNTLG-NYTCVCPAEYLQVNGGNN 1644
Query: 800 CQDVDECQPSRCHPDAFCYN 819
C D+ + R H + C N
Sbjct: 1645 CMDMRKSVCFR-HYNGTCQN 1663
Score = 42.4 bits (98), Expect = 0.003
Identities = 53/193 (27%), Positives = 67/193 (34%), Gaps = 42/193 (21%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDE-----------CSE 716
N C GT C P + F C C GF +G C+D + CS
Sbjct: 1978 NLCLFGT--------CTNSPGS-FQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
Query: 717 QPSVCGSHT--ICNNHPGTF---RCECV--EGYQFSDE------GTCVAVVDQRP-INYC 762
+ + T C+ PG CE EG E G D R +N C
Sbjct: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNEC 2088
Query: 763 ETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD--GQACQDVDECQPSRCHPDAFCYNT 820
N + C+ T GS + C C G+S D G C D DEC C N
Sbjct: 2089 A---ENPGVCTNGVCVNTDGS-FRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNV 2144
Query: 821 PGSFTCQCKPGYQ 833
G F C C G++
Sbjct: 2145 IGGFECACADGFE 2157
Score = 41.6 bits (96), Expect = 0.005
Identities = 32/103 (31%), Positives = 41/103 (39%), Gaps = 23/103 (22%)
Query: 666 DALQNPCY--IGTHGCD--------TNAAC--RPGPRTQFTCE--------CSIGFRGDG 705
D PC+ +G GC T A C G CE C GF +
Sbjct: 181 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 240
Query: 706 RT--CYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSD 746
T C D+DEC P +C + C N G+F C C G++ SD
Sbjct: 241 HTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSD 282
Score = 37.4 bits (85), Expect = 0.090
Identities = 13/36 (36%), Positives = 18/36 (50%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
C H C HA C + F C C+ G+ G+G +C
Sbjct: 1284 CEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
Score = 33.9 bits (76), Expect = 1.00
Identities = 11/36 (30%), Positives = 19/36 (52%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
C + H+CS +C + + C+C G+ G+G C
Sbjct: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC 1360
Score = 32.7 bits (73), Expect = 2.2
Identities = 13/25 (52%), Positives = 14/25 (56%)
Query: 1210 NYCSVNNGGCTHLCLATPGSRTCRC 1234
N C V NGGC C+ T GS C C
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSC 1181
Score = 32.7 bits (73), Expect = 2.2
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 18/59 (30%)
Query: 1205 CPQGH-------------NYCSVNNGGCTH-LCLATPGSRTCRCPD----NTLGVDCIE 1245
CP GH N C+ N G CT+ +C+ T GS C CP + G++C++
Sbjct: 2068 CPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 32.0 bits (71), Expect = 3.8
Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 12/46 (26%)
Query: 1202 LSQCPQGH------------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
L CP+G+ + C+ C LC+ T G+ TCRCP
Sbjct: 2428 LCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCP 2473
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 126 bits (317), Expect = 1e-28
Identities = 95/312 (30%), Positives = 127/312 (40%), Gaps = 81/312 (25%)
Query: 659 PVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSE 716
P R+G D + C I GCDT G + C CS G+ DGR+C DIDEC
Sbjct: 1235 PDRQGCTDI--DECMIMNGGCDTQCTNSEG---SYECSCSEGYALMPDGRSCADIDECEN 1289
Query: 717 QPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCVAVVDQ------------------- 756
P +C C N PG +RC C +G+ S D TC+ V +
Sbjct: 1290 NPDICDGGQ-CTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSF 1348
Query: 757 -----------------RPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQA 799
++ CE G HNCD+ A C+ GS + CSC G+ G+G
Sbjct: 1349 ICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM--HASCLNIPGS-FKCSCREGWIGNGIK 1405
Query: 800 CQDVDECQPS--RCHPDAFCYNTPGSFTCQCKPGYQGDGFRC------------------ 839
C D+DEC +C +A C NTPGS+ C C G+ GDGF C
Sbjct: 1406 CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQC 1465
Query: 840 --VPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCW 897
VPG RC+ E +G A+D + + EC C+ G
Sbjct: 1466 LNVPGAY---RCECE----MGFTPASDSRSCQD----IDECSFQNICVFGTCNNLPGMFH 1514
Query: 898 CVDRDGREVEGT 909
C+ DG E++ T
Sbjct: 1515 CICDDGYELDRT 1526
Score = 124 bits (310), Expect = 7e-28
Identities = 69/183 (37%), Positives = 97/183 (53%), Gaps = 22/183 (12%)
Query: 693 FTCECSIGFRGD--GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-T 749
F C C +G+ D G +C D+DECS+ P C + IC N G+++C C GY ++G T
Sbjct: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQCSCPRGYVLQEDGKT 2529
Query: 750 CVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC--Q 807
C + ++ C+T HNC C+ T G +TC C PGF+ AC D +EC Q
Sbjct: 2530 C------KDLDECQTKQHNCQF----LCVNTLGG-FTCKCPPGFTQHHTACIDNNECGSQ 2578
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKT----RCQHEREHILGAAGAT 863
PS C C NTPGSF+C+C+ G+ D +V++ RCQH ++ILG
Sbjct: 2579 PSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCG 2638
Query: 864 DPQ 866
PQ
Sbjct: 2639 CPQ 2641
Score = 107 bits (267), Expect = 7e-23
Identities = 68/179 (37%), Positives = 87/179 (48%), Gaps = 20/179 (11%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP 731
C GTH C NA C P + + C CS GF GDG TC D+DEC+E ++C + C N P
Sbjct: 1412 CSNGTHQCSINAQCVNTPGS-YRCACSEGFTGDGFTCSDVDECAENINLCENGQ-CLNVP 1469
Query: 732 GTFRCECVEGYQ-FSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCL 790
G +RCEC G+ SD +C + + N C G N ++P CI C
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCN-NLPGMFHCI----------CD 1518
Query: 791 PGFSGD--GQACQDVDEC-QPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEV 844
G+ D G C D+DEC P C + C NTPG + C C P +Q G CV V
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINC-VNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576
Score = 106 bits (264), Expect = 2e-22
Identities = 67/184 (36%), Positives = 82/184 (44%), Gaps = 35/184 (19%)
Query: 693 FTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVA 752
FTC+C GF C D +EC QPS+CG+ IC N PG+F CEC G+ G
Sbjct: 2554 FTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE 2613
Query: 753 VVDQRPINY-CETGLHN------CDIPQR-------AQCI----------------YTGG 782
VD+ N+ C+ G N C PQ QC+ Y
Sbjct: 2614 DVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTL 2673
Query: 783 SSYTCSCLPGFSGD--GQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFR 838
SY C+C GFS D AC DV+EC S+ + C NT G + C C PGY G G
Sbjct: 2674 GSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG-H 2732
Query: 839 CVPG 842
CV G
Sbjct: 2733 CVSG 2736
Score = 99.4 bits (246), Expect = 2e-20
Identities = 58/146 (39%), Positives = 73/146 (50%), Gaps = 17/146 (11%)
Query: 693 FTCECSIGFRGDGR--TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
F CEC GF + C DIDECS ++C + C N PG++RCEC G++ S G C
Sbjct: 1831 FRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC 1890
Query: 751 VAVVDQRPI-NYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQ 807
V + I N C GL C+ G SY C C GF S D C DVDEC+
Sbjct: 1891 VDRNECLEIPNVCSHGL----------CVDLQG-SYQCICHNGFKASQDQTMCMDVDECE 1939
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGYQ 833
C + C NT GS+ C C PG++
Sbjct: 1940 RHPC-GNGTCKNTVGSYNCLCYPGFE 1964
Score = 94.4 bits (233), Expect = 6e-19
Identities = 67/191 (35%), Positives = 80/191 (41%), Gaps = 49/191 (25%)
Query: 693 FTCECSIGFRGD--GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS----- 745
F C C+ GF D R C DIDEC P +CGS IC N PG+F CEC EGY+
Sbjct: 1096 FKCRCNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECECFEGYESGFMMMK 1154
Query: 746 -----DE----------GTCVAVV------------------DQRPINYCETGLHNCDIP 772
DE GTCV D IN C + C
Sbjct: 1155 NCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC--- 1211
Query: 773 QRAQCIYTGGSSYTCSCLPGFSG--DGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKP 830
+ +C+ G+ Y CSC PG+ D Q C D+DEC D C N+ GS+ C C
Sbjct: 1212 RNGKCVNMIGT-YQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSE 1270
Query: 831 GY--QGDGFRC 839
GY DG C
Sbjct: 1271 GYALMPDGRSC 1281
Score = 90.9 bits (224), Expect = 7e-18
Identities = 64/199 (32%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 682 NAACRPGPRTQFTCECSIGFRGDGR-TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVE 740
N C P + + CEC++G++ D C D+DEC+ P G C N PG++ C+C
Sbjct: 507 NGRCIPTV-SSYRCECNMGYKQDANGDCIDVDECTSNPCTNGD---CVNTPGSYYCKCHA 562
Query: 741 GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQ 798
G+Q + T A +D I+ C + N + + +C+ T G S+ C C GF + DG+
Sbjct: 563 GFQRTP--TKQACID---IDEC---IQNGVLCKNGRCVNTDG-SFQCICNAGFELTTDGK 613
Query: 799 ACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRCVPGEVEKTRCQHEREHI 856
C D DEC + + C N GSF C CKPG+ +G C + +T H
Sbjct: 614 NCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHC 673
Query: 857 LGAAGATDPQRPIPPGLFV 875
+ + G+ + PPGL V
Sbjct: 674 INSEGSF--RCDCPPGLAV 690
Score = 90.9 bits (224), Expect = 7e-18
Identities = 69/220 (31%), Positives = 93/220 (42%), Gaps = 36/220 (16%)
Query: 666 DALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDG--RTCYDIDECSEQPSVCGS 723
+ NPC TN C P + + C+C GF+ + C DIDEC + +C +
Sbjct: 538 ECTSNPC--------TNGDCVNTPGSYY-CKCHAGFQRTPTKQACIDIDECIQNGVLCKN 588
Query: 724 HTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGG 782
C N G+F+C C G++ + +G CV + N C G+ CI G
Sbjct: 589 GR-CVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGM----------CINEDG 637
Query: 783 SSYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFR 838
S + C C PGF + +G+ C DVDECQ + C N+ GSF C C PG DG
Sbjct: 638 S-FKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRV 696
Query: 839 CVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC 878
CV H R G RP P + EC
Sbjct: 697 CVD--------THMRSTCYGGIKKGVCVRPFPGAVTKSEC 728
Score = 90.1 bits (222), Expect = 1e-17
Identities = 64/191 (33%), Positives = 85/191 (44%), Gaps = 35/191 (18%)
Query: 695 CECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVV 754
C G+ DGR DIDEC P++C ++ C N G+FRC C GY GT +
Sbjct: 2437 CPHGPGYTTDGR---DIDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
Query: 755 DQ-----RPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQ 807
D+ +P NY C T GS Y CSC G+ DG+ C+D+DECQ
Sbjct: 2493 DECSQSPKPCNYI--------------CKNTEGS-YQCSCPRGYVLQEDGKTCKDLDECQ 2537
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQR 867
+ + C NT G FTC+C PG+ C ++ C + + GA G
Sbjct: 2538 TKQHNCQFLCVNTLGGFTCKCPPGFTQHHTAC----IDNNEC-GSQPSLCGAKGICQN-- 2590
Query: 868 PIPPGLFVPEC 878
PG F EC
Sbjct: 2591 --TPGSFSCEC 2599
Score = 89.4 bits (220), Expect = 2e-17
Identities = 67/232 (28%), Positives = 91/232 (39%), Gaps = 55/232 (23%)
Query: 653 LSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG--DGRTCYD 710
L + + P RE D N C + + C N C T + C C+ G++ D + C D
Sbjct: 1187 LGHELSPSREDCVDI--NECSLSDNLC-RNGKCVNMIGT-YQCSCNPGYQATPDRQGCTD 1242
Query: 711 IDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCD 770
IDEC C T C N G++ C C EGY +G A +D+ CE CD
Sbjct: 1243 IDECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDGRSCADIDE-----CENNPDICD 1295
Query: 771 ------IPQRAQCIYTGG--------------------------------SSYTCSCLPG 792
IP +C+ G S+ C C G
Sbjct: 1296 GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLG 1355
Query: 793 FS--GDGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
+S C DVDEC+ C A C N PGSF C C+ G+ G+G +C+
Sbjct: 1356 YSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCI 1407
Score = 88.6 bits (218), Expect = 3e-17
Identities = 62/205 (30%), Positives = 87/205 (42%), Gaps = 39/205 (19%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICNNH 730
C G + C NA C P + + CEC+ GF+ C D +EC E P+VC SH +C +
Sbjct: 1854 CSNGDNLCQRNADCINSPGS-YRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDL 1911
Query: 731 PGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGL-------------------HNCDI 771
G+++C C G++ S + T VD+ + C G HN D
Sbjct: 1912 QGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDC 1971
Query: 772 PQRAQCIYTGGS------------SYTCSCLPGF--SGDGQACQDVDECQ--PSRCHPDA 815
+C G S+ C C G+ + DG+ C D +EC P C P
Sbjct: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGT 2031
Query: 816 FCYNTPGSFTCQCKPGYQGDGFRCV 840
C N GSF C C PGY+ C+
Sbjct: 2032 -CQNLEGSFRCICPPGYEVKSENCI 2055
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/201 (31%), Positives = 88/201 (43%), Gaps = 40/201 (19%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTICNN 729
C G H C++ F C C G R DG C D +EC +P +C + C N
Sbjct: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGR-CVN 2356
Query: 730 HPGTFRCECVEGYQFSDEGT---------CVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
G++RCEC EG+Q S GT C A V Q C+ + ++ +++C
Sbjct: 2357 IIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQ---TICQMASSSRNLVTKSECCCD 2413
Query: 781 GGSSYTCSCL-----------------PGFSGDGQACQDVDECQ--PSRCHPDAFCYNTP 821
GG + C PG++ DG +D+DEC+ P+ C + C NT
Sbjct: 2414 GGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDG---RDIDECKVMPNLC-TNGQCINTM 2469
Query: 822 GSFTCQCKPGYQGD--GFRCV 840
GSF C CK GY D G C+
Sbjct: 2470 GSFRCFCKVGYTTDISGTSCI 2490
Score = 85.1 bits (209), Expect = 4e-16
Identities = 63/202 (31%), Positives = 96/202 (47%), Gaps = 36/202 (17%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIG--FRGDGRTCYDIDECSEQPSVCGSHTICNN 729
C + CD N CR P + ++C C G FR + TC DI+EC P V G+ C N
Sbjct: 814 CLVNRLLCD-NGLCRNTPGS-YSCTCPPGYVFRTETETCEDINECESNPCVNGA---CRN 868
Query: 730 HPGTFRCECVEGYQFSD---------EGTC-VAVVDQRPINYCETGLHNCDIPQRAQCIY 779
+ G+F CEC G + S +GTC + + D R CE ++ + +++C
Sbjct: 869 NLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSR----CEVNINGATL--KSECCA 922
Query: 780 TGGSSY---------TCSCLPGFSG-DGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQ 827
T G+++ +C G + G C+DV+EC+ P C P+ C N+ GSF C+
Sbjct: 923 TLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCE 981
Query: 828 CKPGYQGDGFRCVPGEVEKTRC 849
C G DG V ++ +C
Sbjct: 982 CPEGLTLDGTGRVCLDIRMEQC 1003
Score = 82.0 bits (201), Expect = 3e-15
Identities = 68/213 (31%), Positives = 86/213 (40%), Gaps = 58/213 (27%)
Query: 675 GTHGCDTN------AACRPGP----RTQFTCECSIGFRGDGRTCYDIDECSEQPSVC--G 722
G + DTN +C PG F C C G+ C DI+EC E P++C G
Sbjct: 2011 GKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFG 2070
Query: 723 SHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHN--CDIPQRAQCIYT 780
S C N PG F+C C G+ SD G D R ++C T N C +P+ T
Sbjct: 2071 S---CTNTPGGFQCLCPPGFVLSDNGR--RCFDTRQ-SFCFTNFENGKCSVPK---AFNT 2121
Query: 781 GGSSYTCSCLPGFSGDGQACQ-----------------------------DVDEC--QPS 809
+ CS +PG G G C+ DV+EC P
Sbjct: 2122 TKAKCCCSKMPG-EGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPG 2180
Query: 810 RCHPDAFCYNTPGSFTCQCKPGYQGD--GFRCV 840
C + C NT GSF C+C GY D G RCV
Sbjct: 2181 ICS-NGQCINTDGSFRCECPMGYNLDYTGVRCV 2212
Score = 75.9 bits (185), Expect = 2e-13
Identities = 55/169 (32%), Positives = 75/169 (44%), Gaps = 19/169 (11%)
Query: 677 HGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
H C N C+ + C C GF C DIDECS + C N G+F+
Sbjct: 1941 HPCG-NGTCK-NTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFK 1998
Query: 736 CECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794
C C EGY+ + +G C+ N C +C P Q + S+ C C PG+
Sbjct: 1999 CLCNEGYELTPDGKNCIDT------NECVALPGSCS-PGTCQNLE---GSFRCICPPGYE 2048
Query: 795 GDGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
+ C D++EC P+ C + C NTPG F C C PG+ +G RC
Sbjct: 2049 VKSENCIDINECDEDPNICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRC 2096
Score = 71.6 bits (174), Expect = 4e-12
Identities = 56/177 (31%), Positives = 80/177 (45%), Gaps = 28/177 (15%)
Query: 672 CYIGTH-GCDTNAACRPGPRTQFT-CECSIGF--RGD---GRTCY-DIDECSEQPSVCGS 723
C +G G + +PG + T C GF RGD GR Y DI+EC P +C +
Sbjct: 1027 CAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC-T 1085
Query: 724 HTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPI--NYCETGLHNCDIPQRAQCIYTG 781
+ C N G+F+C C G+ E +D+ I + C +G+ C+ T
Sbjct: 1086 YGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI----------CVNTP 1135
Query: 782 GSSYTCSCLPGFSGD---GQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQ 833
G S+ C C G+ + C D+DEC+ P C C NT GSF C C G++
Sbjct: 1136 G-SFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCDCPLGHE 1190
Score = 68.2 bits (165), Expect = 5e-11
Identities = 65/227 (28%), Positives = 83/227 (36%), Gaps = 79/227 (34%)
Query: 679 CDTNAACRPG----PRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTICNNHPG 732
C T C G F C C GF +GR C D+DEC + P +C + C N G
Sbjct: 621 CTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGIC-MNGHCINSEG 678
Query: 733 TFRCE-------------CVEGYQFSD------EGTCVA--------------------- 752
+FRC+ CV+ + S +G CV
Sbjct: 679 SFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG 738
Query: 753 ------------------------VVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS 788
VD R IN C + DI C GS Y C+
Sbjct: 739 EPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECAL---DPDICANGICENLRGS-YRCN 794
Query: 789 CLPGFSGD--GQACQDVDECQPSRCHPD-AFCYNTPGSFTCQCKPGY 832
C G+ D G+ C D+DEC +R D C NTPGS++C C PGY
Sbjct: 795 CNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 841
Score = 67.8 bits (164), Expect = 6e-11
Identities = 48/135 (35%), Positives = 62/135 (45%), Gaps = 18/135 (13%)
Query: 711 IDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCD 770
ID C ++C + C ++RCEC GY+ G C+ VD+ N C G
Sbjct: 495 IDICKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCID-VDECTSNPCTNG----- 547
Query: 771 IPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-QPSRCHPDAFCYNTPGSFTCQ 827
C+ T G SY C C GF + QAC D+DEC Q + C NT GSF C
Sbjct: 548 -----DCVNTPG-SYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCI 601
Query: 828 CKPGYQ--GDGFRCV 840
C G++ DG CV
Sbjct: 602 CNAGFELTTDGKNCV 616
Score = 66.2 bits (160), Expect = 2e-10
Identities = 69/245 (28%), Positives = 94/245 (38%), Gaps = 58/245 (23%)
Query: 693 FTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGY-QFSDEGT 749
F CEC G+ D R C DIDEC P VCG T C N G + C C Y Q +
Sbjct: 1673 FQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-CYNTLGNYTCICPPEYMQVNGGHN 1731
Query: 750 CVAVVDQ---RPIN--YCETGLHNCDIPQRAQCIYTGGSSYT-----------------C 787
C+ + R N CE L + C Y G ++ C
Sbjct: 1732 CMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
Query: 788 SCLPGFSGD---GQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPG 842
+PGF+ D G+A D+DEC+ P C + C N GSF C+C G+ + V
Sbjct: 1792 GNIPGFTFDIHTGKAV-DIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCE 1849
Query: 843 EVEK-----TRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCW 897
++++ CQ + I PG + EC A +P
Sbjct: 1850 DIDECSNGDNLCQRNADCINS------------PGSYRCECAAGFKLSPNGA-------- 1889
Query: 898 CVDRD 902
CVDR+
Sbjct: 1890 CVDRN 1894
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/137 (29%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGD--GRTCYDIDECSEQPSVCGSHTIC 727
N C + C N C R + C C+ G+ D GR C DIDEC +C + +C
Sbjct: 770 NECALDPDIC-ANGICE-NLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLC-DNGLC 826
Query: 728 NNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTC 787
N PG++ C C GY F E +++ N C G ++ S+ C
Sbjct: 827 RNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNL-----------GSFNC 875
Query: 788 SCLPG--FSGDGQACQD 802
C PG S G C D
Sbjct: 876 ECSPGSKLSSTGLICID 892
Score = 57.0 bits (136), Expect = 1e-07
Identities = 54/203 (26%), Positives = 76/203 (37%), Gaps = 41/203 (20%)
Query: 672 CYIGTHGCDTNAAC---------RPGPRTQFTCECSIGF-RGDGRTCYDIDECSEQPSVC 721
C + +G + C P R + C G R G TC D++EC P VC
Sbjct: 907 CEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVC 966
Query: 722 GSHTICNNHPGTFRCECVEG------------------YQFSDEGTCVAVVDQR-PINYC 762
+ C N G+F CEC EG Y DE C+ V + ++ C
Sbjct: 967 PNGR-CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDAC 1025
Query: 763 ETGLHNCDIPQRAQCIYTGGSSYTCSCL--PGFSGDGQAC------QDVDECQ--PSRCH 812
+ + +C G Y C GF+ G +D++EC+ P C
Sbjct: 1026 CCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCT 1085
Query: 813 PDAFCYNTPGSFTCQCKPGYQGD 835
C NT GSF C+C G+ D
Sbjct: 1086 YGK-CRNTIGSFKCRCNSGFALD 1107
Score = 51.6 bits (122), Expect = 5e-06
Identities = 49/170 (28%), Positives = 66/170 (38%), Gaps = 33/170 (19%)
Query: 693 FTCECSIGF--RGDGRTCYDIDE-----------CSEQPS--VCGSHTICNNHPGTF--- 734
F C C GF +GR C+D + CS + + C+ PG
Sbjct: 2079 FQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGD 2138
Query: 735 ---RCECVEGYQFSD-----EGTCVAVVDQRP-INYCETGLHNCDIPQRAQCIYTGGSSY 785
C + F D GT ++ D R +N C L + I QCI T GS +
Sbjct: 2139 PCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNEC---LESPGICSNGQCINTDGS-F 2194
Query: 786 TCSCLPGFSGD--GQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ 833
C C G++ D G C D DEC + C N GSF C C G++
Sbjct: 2195 RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE 2244
Score = 50.8 bits (120), Expect = 8e-06
Identities = 69/256 (26%), Positives = 91/256 (35%), Gaps = 61/256 (23%)
Query: 696 ECSIGFRGDGRTCYDIDECSEQPSVCGSHT---ICNNHP-------GTFRCECVEGYQFS 745
+CS+ G TC D D C Q G++ +C N G RC CV G+
Sbjct: 148 QCSVRCMNGG-TCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGP 205
Query: 746 D------EGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSY--TCSCLP------ 791
G C V+ + TG+ + + C T G ++ C P
Sbjct: 206 QCERDYRTGPCFTQVNNQMCQGQLTGI----VCTKTLCCATIGRAWGHPCEMCPAQPQPC 261
Query: 792 --GFSGDGQ--ACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQG----------D 835
GF + + ACQDVDECQ P C C NT GSF C+C G++ D
Sbjct: 262 RRGFIPNIRTGACQDVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCEDID 320
Query: 836 GFRCVPGEVEKTRCQHEREHIL-----GAAGATDPQRPIP-------PGLFVPEC--DAH 881
+PG E C + G +TD R I GL C +
Sbjct: 321 ECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELP 380
Query: 882 GHYAPTQCHGSTGYCW 897
G QC G CW
Sbjct: 381 GRMTKMQCCCEPGRCW 396
Score = 43.5 bits (101), Expect = 0.001
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
C+N HQCS++A+C + + C+C G+TG+G C
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1447
Score = 40.8 bits (94), Expect = 0.008
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCV 426
C H C +HA C + F CSC G+ GNG +C+
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCI 1407
Score = 30.8 bits (68), Expect = 8.4
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 5/39 (12%)
Query: 1202 LSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1240
L +C G + CS+N C+ TPGS C C + G
Sbjct: 1409 LDECSNGTHQCSINAQ-----CVNTPGSYRCACSEGFTG 1442
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 125 bits (313), Expect = 3e-28
Identities = 83/226 (36%), Positives = 99/226 (43%), Gaps = 52/226 (23%)
Query: 659 PVREGSPDALQ----NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDID 712
P +PD L + C I GC+T G + C C GF D R+C DID
Sbjct: 1184 PGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEG---SYECSCQPGFALMPDQRSCTDID 1240
Query: 713 ECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCVAV--VDQRP----------- 758
EC + P++C C N PG +RC C +G+ S D TCV V D P
Sbjct: 1241 ECEDNPNICDGGQ-CTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENT 1299
Query: 759 -----------------------INYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG 795
IN CE G HNC + A C T G S+ CSC PG+ G
Sbjct: 1300 KGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCG--KHAVCTNTAG-SFKCSCSPGWIG 1356
Query: 796 DGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
DG C D+DEC C A C NT GS+ C CK GY GDGF C
Sbjct: 1357 DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1402
Score = 123 bits (309), Expect = 1e-27
Identities = 77/223 (34%), Positives = 99/223 (44%), Gaps = 27/223 (12%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNN 729
N C IG H C +A C F C CS G+ GDG C D+DECS +C H C N
Sbjct: 1324 NECEIGAHNCGKHAVCT-NTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKN 1382
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
G++RC C EGY D TC ++ C L+ C QC+ G Y C C
Sbjct: 1383 TMGSYRCLCKEGYT-GDGFTCT------DLDECSENLNLCG---NGQCLNAPG-GYRCEC 1431
Query: 790 LPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGD--GFRCVPGEVE 845
GF S DG+AC+D+DEC C+N PG F C+C+ GY+ D G C +
Sbjct: 1432 DMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNC----TD 1487
Query: 846 KTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQ 888
C I G T PG ++ +C PT+
Sbjct: 1488 VNECLDPTTCISGNCVNT-------PGSYICDCPPDFELNPTR 1523
Score = 111 bits (278), Expect = 4e-24
Identities = 65/194 (33%), Positives = 97/194 (50%), Gaps = 24/194 (12%)
Query: 685 CRPGP----RTQFTCECSIGFRGD--GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
CR G R + C C G+ D G +C D++EC++ P C + IC N G+++C C
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPC--NFICKNTEGSYQCSC 2470
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQ 798
+GY ++G +D+ C T HNC C+ T G +TC C PGF+
Sbjct: 2471 PKGYILQEDGRSCKDLDE-----CATKQHNCQF----LCVNTIGG-FTCKCPPGFTQHHT 2520
Query: 799 ACQDVDECQP--SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKT----RCQHE 852
+C D +EC + C C NTPGSFTC+C+ G+ D +V++ RCQH
Sbjct: 2521 SCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHG 2580
Query: 853 REHILGAAGATDPQ 866
++I+G + PQ
Sbjct: 2581 CQNIIGGYRCSCPQ 2594
Score = 102 bits (254), Expect = 2e-21
Identities = 65/188 (34%), Positives = 90/188 (47%), Gaps = 20/188 (10%)
Query: 651 YALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYD 710
+ S S G + +G + C GTH C +A C+ + C C G+ GDG TC D
Sbjct: 1346 FKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCK-NTMGSYRCLCKEGYTGDGFTCTD 1404
Query: 711 IDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPI-NYCETG-LHN 768
+DECSE ++CG+ C N PG +RCEC G+ S +G +D+ + N C G HN
Sbjct: 1405 LDECSENLNLCGNGQ-CLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHN 1463
Query: 769 CDIPQRAQCIYTGGSSYTCSCLPGFSGD--GQACQDVDEC-QPSRCHPDAFCYNTPGSFT 825
+ C C G+ D G C DV+EC P+ C C NTPGS+
Sbjct: 1464 LP------------GLFRCECEIGYELDRSGGNCTDVNECLDPTTC-ISGNCVNTPGSYI 1510
Query: 826 CQCKPGYQ 833
C C P ++
Sbjct: 1511 CDCPPDFE 1518
Score = 102 bits (253), Expect = 3e-21
Identities = 61/176 (34%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 674 IGTHGCDTNA-ACRPGP----RTQFTCECSIGFRGD-GRT-CYDIDECSEQPSVCGSHTI 726
+ + CD N C G + F C C +G+ G G+T C DI+EC CG H +
Sbjct: 1279 VDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAV 1338
Query: 727 CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYT 786
C N G+F+C C G+ D C ++ C G H C Q A C T G SY
Sbjct: 1339 CTNTAGSFKCSCSPGW-IGDGIKCT------DLDECSNGTHMCS--QHADCKNTMG-SYR 1388
Query: 787 CSCLPGFSGDGQACQDVDECQPS-RCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
C C G++GDG C D+DEC + + C N PG + C+C G+ DG C
Sbjct: 1389 CLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKAC 1444
Score = 99.0 bits (245), Expect = 3e-20
Identities = 68/190 (35%), Positives = 91/190 (47%), Gaps = 26/190 (13%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGR-TCYDIDECSEQPSVCGSHTICNNH 730
C + + C N C P P + CEC+ GF+ D R C D+DEC + P G C N+
Sbjct: 453 CQLVRYLCQ-NGRCIPTPGS-CRCECNKGFQLDLRGECIDVDECEKNPCAGGE---CINN 507
Query: 731 PGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCL 790
G++ C+C GYQ + + + R I+ C L N I +CI T GS + C C
Sbjct: 508 QGSYTCQCRAGYQ-----STLTRTECRDIDEC---LQNGRICNNGRCINTDGS-FHCVCN 558
Query: 791 PGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRC------- 839
GF + DG+ C+D+DEC + C N GSF C CKPG+Q DG C
Sbjct: 559 AGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECE 618
Query: 840 VPGEVEKTRC 849
PG RC
Sbjct: 619 TPGICMNGRC 628
Score = 96.7 bits (239), Expect = 1e-19
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 35/184 (19%)
Query: 693 FTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVA 752
FTC+C GF +C D +EC+ ++CGS IC N PG+F CEC G+ G+
Sbjct: 2507 FTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCE 2566
Query: 753 VVDQRPINY-CETGLHN------CDIPQR-------AQCI---------YTGGS------ 783
VD+ N+ C+ G N C PQ QC+ GG+
Sbjct: 2567 DVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTL 2626
Query: 784 -SYTCSCLPGFSGD--GQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY--QGDGFR 838
SY C C GF + CQD++EC ++ C NT G + C C PGY G G
Sbjct: 2627 GSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQG-H 2685
Query: 839 CVPG 842
CV G
Sbjct: 2686 CVSG 2689
Score = 95.1 bits (235), Expect = 4e-19
Identities = 52/145 (35%), Positives = 73/145 (50%), Gaps = 15/145 (10%)
Query: 693 FTCECSIGFRGDG---RTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGT 749
F C+C G+ + C DIDEC P +C +C+N G++RCEC G+Q S +
Sbjct: 1093 FECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGG-VCHNTEGSYRCECPPGHQLSPNIS 1151
Query: 750 CVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG--DGQACQDVDECQ 807
A +D IN CE H C +C+ G Y C+C PG+ D C D+DEC
Sbjct: 1152 --ACID---INECELSAHLCP---NGRCVNLIGK-YQCACNPGYHSTPDRLFCVDIDECS 1202
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGY 832
+ FC N+ GS+ C C+PG+
Sbjct: 1203 IMNGGCETFCTNSEGSYECSCQPGF 1227
Score = 93.6 bits (231), Expect = 1e-18
Identities = 55/144 (38%), Positives = 73/144 (50%), Gaps = 16/144 (11%)
Query: 693 FTCECSIGFRGDGR--TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
F CEC +GF + + C DIDEC P VC + C N G++RC+C GY+F+ G C
Sbjct: 1789 FRCECPVGFFYNDKLLVCEDIDECQNGP-VCQRNAECINTAGSYRCDCKPGYRFTSTGQC 1847
Query: 751 VAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQP 808
N C+ + C QCI T GS Y C C GF + D C D++EC+
Sbjct: 1848 ------NDRNECQEIPNIC---SHGQCIDTVGSFY-CLCHTGFKTNDDQTMCLDINECER 1897
Query: 809 SRCHPDAFCYNTPGSFTCQCKPGY 832
C + C NT GSF C+C G+
Sbjct: 1898 DAC-GNGTCRNTIGSFNCRCNHGF 1920
Score = 91.3 bits (225), Expect = 5e-18
Identities = 55/153 (35%), Positives = 76/153 (49%), Gaps = 19/153 (12%)
Query: 693 FTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
F C C GF+ D C DI+EC CG+ T C N G+F C C G+ S C
Sbjct: 1872 FYCLCHTGFKTNDDQTMCLDINECERD--ACGNGT-CRNTIGSFNCRCNHGFILSHNNDC 1928
Query: 751 VAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-- 806
+ V + C +G N ++ + QCI T GS + C C G+ + DG+ C D++EC
Sbjct: 1929 IDVDE------CASG--NGNLCRNGQCINTVGS-FQCQCNEGYEVAPDGRTCVDINECLL 1979
Query: 807 QPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
+P +C P C N GS+ C C PGY +C
Sbjct: 1980 EPRKCAPGT-CQNLDGSYRCICPPGYSLQNEKC 2011
Score = 91.3 bits (225), Expect = 5e-18
Identities = 66/194 (34%), Positives = 87/194 (44%), Gaps = 28/194 (14%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQ----FTCECSIGFR-GDGRTCYDIDECSEQPSVCGSH 724
N C + T C C G F C C GF G TC DI+EC++ P +C
Sbjct: 2162 NEC-VDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFR 2220
Query: 725 TICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSS 784
C N G++ C+C GY ++ D+ CE G H+C Q +C G+
Sbjct: 2221 --CVNTYGSYECKCPVGYVLREDRRMCKDEDE-----CEEGKHDCTEKQM-ECKNLIGT- 2271
Query: 785 YTCSCLPGFSG--DGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Y C C PG+ DG+ C D +ECQ P C + C NT GS+TC+C DGF
Sbjct: 2272 YMCICGPGYQRRPDGEGCVDENECQTKPGICE-NGRCLNTRGSYTCEC-----NDGFTAS 2325
Query: 841 PGEVEKTRCQHERE 854
P + E C RE
Sbjct: 2326 PNQDE---CLDNRE 2336
Score = 90.1 bits (222), Expect = 1e-17
Identities = 69/211 (32%), Positives = 97/211 (45%), Gaps = 38/211 (18%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTIC 727
N C + + CD N CR P + F C C GF + D +TC DIDEC P + G +C
Sbjct: 767 NECVLNSLLCD-NGQCRNTPGS-FVCTCPKGFIYKPDLKTCEDIDECESSPCING---VC 821
Query: 728 NNHPGTFRCECVEGYQFSD---------EGTC-VAVVDQRPINYCETGLHNCDIPQRAQC 777
N PG+F CEC +GTC V+D R CE ++ + ++QC
Sbjct: 822 KNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGR----CEININGATL--KSQC 875
Query: 778 IYTGGSSYTCSCL---------PGFSG-DGQACQDVDECQ--PSRCHPDAFCYNTPGSFT 825
+ G+++ C G+S G C+D+DEC+ P C + C NT GSF
Sbjct: 876 CSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVC-KNGLCVNTRGSFK 934
Query: 826 CQCKPGYQGD--GFRCVPGEVEKTRCQHERE 854
CQC G D G C+ +E ++E E
Sbjct: 935 CQCPSGMTLDATGRICLDIRLETCFLRYEDE 965
Score = 84.3 bits (207), Expect = 6e-16
Identities = 59/171 (34%), Positives = 80/171 (46%), Gaps = 19/171 (11%)
Query: 685 CRPGPR---TQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEG 741
C+P P ++ CS G G DI+EC+ P +C + IC N GT++C C G
Sbjct: 696 CQPCPAQNSAEYQALCSSG-PGMTSAGSDINECALDPDIC-PNGICENLRGTYKCICNSG 753
Query: 742 YQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQ 798
Y+ G CV IN C CD QC T G S+ C+C GF D +
Sbjct: 754 YEVDSTGKNCV------DINECVLNSLLCD---NGQCRNTPG-SFVCTCPKGFIYKPDLK 803
Query: 799 ACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRC 849
C+D+DEC+ S C + C N+PGSF C+C D + + E K C
Sbjct: 804 TCEDIDECESSPC-INGVCKNSPGSFICECSSESTLDPTKTICIETIKGTC 853
Score = 82.0 bits (201), Expect = 3e-15
Identities = 58/148 (39%), Positives = 78/148 (52%), Gaps = 21/148 (14%)
Query: 710 DIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNC 769
DIDEC E P VC + +C N G+FRCEC G+ ++D+ +D+ C+ G
Sbjct: 1766 DIDECREIPGVC-ENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDE-----CQNG---- 1815
Query: 770 DIPQR-AQCIYTGGSSYTCSCLPG--FSGDGQACQDVDECQ--PSRCHPDAFCYNTPGSF 824
+ QR A+CI T G SY C C PG F+ GQ C D +ECQ P+ C C +T GSF
Sbjct: 1816 PVCQRNAECINTAG-SYRCDCKPGYRFTSTGQ-CNDRNECQEIPNIC-SHGQCIDTVGSF 1872
Query: 825 TCQCKPGYQ--GDGFRCVP-GEVEKTRC 849
C C G++ D C+ E E+ C
Sbjct: 1873 YCLCHTGFKTNDDQTMCLDINECERDAC 1900
Score = 79.0 bits (193), Expect = 3e-14
Identities = 54/169 (31%), Positives = 77/169 (45%), Gaps = 22/169 (13%)
Query: 675 GTHGCDTNAACRPGPRTQFTCECSIGFRG----DGRTCY-DIDECSEQPSVCGSHTICNN 729
GT C+ R P + C GF +G+ + DI+EC PS+C +H C N
Sbjct: 989 GTEECE-ECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLC-THGKCRN 1046
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
G+F+C C G+ E +D+ I+ D+ R QC+ T G + C C
Sbjct: 1047 TIGSFKCRCDSGFALDSEERNCTDIDECRISP--------DLCGRGQCVNTPGD-FECKC 1097
Query: 790 LPGFSGDGQA---CQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQ 833
G+ C D+DECQ P C C+NT GS+ C+C PG+Q
Sbjct: 1098 DEGYESGFMMMKNCMDIDECQRDPLLCR-GGVCHNTEGSYRCECPPGHQ 1145
Score = 79.0 bits (193), Expect = 3e-14
Identities = 69/234 (29%), Positives = 95/234 (40%), Gaps = 44/234 (18%)
Query: 666 DALQNPCYIGTHG--------CDTNAACRPGPRTQFT-----------CECSIGFRGDGR 706
+ LQN C IG+ C + GP + C GF +G
Sbjct: 2342 EVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGA 2401
Query: 707 TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGL 766
DIDEC VC + C N G++ C C GY GT + VD +N C
Sbjct: 2402 ---DIDECKVIHDVCRNGE-CVNDRGSYHCICKTGYTPDITGT--SCVD---LNECNQAP 2452
Query: 767 HNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSF 824
C+ C T GS Y CSC G+ DG++C+D+DEC + + C NT G F
Sbjct: 2453 KPCNFI----CKNTEGS-YQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGF 2507
Query: 825 TCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC 878
TC+C PG+ C ++ C + ++ G+ G PG F EC
Sbjct: 2508 TCKCPPGFTQHHTSC----IDNNECTSD-INLCGSKGICQN----TPGSFTCEC 2552
Score = 72.0 bits (175), Expect = 3e-12
Identities = 54/191 (28%), Positives = 70/191 (36%), Gaps = 44/191 (23%)
Query: 685 CRPGPRTQ----FTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVE 740
C PG + C C G+ C DIDEC E+P +C T C+N G+F+C C E
Sbjct: 1984 CAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGT-CSNTEGSFKCLCPE 2042
Query: 741 GYQFSDEGTCVAVVDQRPINYCETGLHN--CDIPQRAQCIYTGGSSYTCSCLPGFSGDGQ 798
G+ S G D R ++YC C P+ S C C G G
Sbjct: 2043 GFSLSSSGR--RCQDLR-MSYCYAKFEGGKCSSPKSRN-----HSKQECCCALKGEGWGD 2094
Query: 799 ACQ-----------------------------DVDECQPSRCHPDAFCYNTPGSFTCQCK 829
C+ D+DEC+ C NT GS+ C+C
Sbjct: 2095 PCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECP 2154
Query: 830 PGYQGDGFRCV 840
GY G CV
Sbjct: 2155 FGYILAGNECV 2165
Score = 63.2 bits (152), Expect = 2e-09
Identities = 41/115 (35%), Positives = 55/115 (47%), Gaps = 16/115 (13%)
Query: 693 FTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTC 750
F C+C+ G+ DGRTC DI+EC +P C T C N G++RC C GY +E
Sbjct: 1954 FQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGYSLQNEKC- 2011
Query: 751 VAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDV 803
I+ C + +I C T G S+ C C GF S G+ CQD+
Sbjct: 2012 ------EDIDEC---VEEPEICALGTCSNTEG-SFKCLCPEGFSLSSSGRRCQDL 2056
Score = 56.6 bits (135), Expect = 1e-07
Identities = 57/185 (30%), Positives = 82/185 (44%), Gaps = 34/185 (18%)
Query: 657 IGPVREGSPDALQNPCYI-----GTHGCDTNAACRPGPR-TQFTCECSIGFRGDGRTCYD 710
+ P R G D CY+ G +G DT + G ++ +C CS+G + G C
Sbjct: 1519 LNPTRVGCVDTRSGNCYLDIRPRGDNG-DTACSNEIGVGVSKASCCCSLG-KAWGTPC-- 1574
Query: 711 IDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCD 770
+ C P+V S ++ C G F V + D I+ C+ C
Sbjct: 1575 -EMC---PAVNTSE---------YKILCPGGEGFRPNPITVILED---IDECQELPGLC- 1617
Query: 771 IPQRAQCIYTGGSSYTCSCLPGF--SGDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQ 827
Q +CI T GS + C C G+ + D + C DV+EC+ P C P CYNT G++TC
Sbjct: 1618 --QGGKCINTFGS-FQCRCPTGYYLNEDTRVCDDVNECETPGICGPGT-CYNTVGNYTCI 1673
Query: 828 CKPGY 832
C P Y
Sbjct: 1674 CPPDY 1678
Score = 55.8 bits (133), Expect = 2e-07
Identities = 51/173 (29%), Positives = 68/173 (39%), Gaps = 40/173 (23%)
Query: 697 CSIGF-RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG------- 748
C G+ R G C DIDEC P VC + +C N G+F+C+C G G
Sbjct: 896 CGKGYSRIKGTQCEDIDECEVFPGVC-KNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954
Query: 749 --TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCL---------------- 790
TC + G H D A C G + T C
Sbjct: 955 LETCFLRYEDEECTLPIAGRHRMD----ACCCSVGAAWGTEECEECPMRNTPEYEELCPR 1010
Query: 791 -PGFSG----DGQAC-QDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
PGF+ +G+ +D++EC+ PS C C NT GSF C+C G+ D
Sbjct: 1011 GPGFATKEITNGKPFFKDINECKMIPSLC-THGKCRNTIGSFKCRCDSGFALD 1062
Score = 53.5 bits (127), Expect = 1e-06
Identities = 87/322 (27%), Positives = 112/322 (34%), Gaps = 94/322 (29%)
Query: 673 YIGTH--------GCDTNAACRPGPRTQFTCECSIGFRG-----DGRT--CYDI---DEC 714
YIGTH GC C R C C+ GF G D RT C+ + C
Sbjct: 140 YIGTHCGQPVCESGCLNGGRCVAPNR----CACTYGFTGPQCERDYRTGPCFTVISNQMC 195
Query: 715 SEQPS--VCGSHTICNN------HPGTFRCE--------CVEGYQFSDE-GTCVAVVDQR 757
Q S VC C HP CE C G+ + G C +
Sbjct: 196 QGQLSGIVCTKTLCCATVGRAWGHP----CEMCPAQPHPCRRGFIPNIRTGAC------Q 245
Query: 758 PINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD--GQACQDVDECQ--PSRCHP 813
++ C+ C Q CI T GS + C C G + Q C+D+DEC P C
Sbjct: 246 DVDECQAIPGLC---QGGNCINTVGS-FECKCPAGHKLNEVSQKCEDIDECSTIPGICEG 301
Query: 814 DAFCYNTPGSFTCQCKPGY--QGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPP 871
C NT S+ C+C PG+ DG RC+ +V C + G Q P
Sbjct: 302 GE-CTNTVSSYFCKCPPGFYTSPDGTRCI--DVRPGYC-----YTALTNGRCSNQLP--- 350
Query: 872 GLFVPECDAHGHYAPTQCHGSTGYCW----------CVDRDGREVEGTRTRPGMTPPCLS 921
QC G CW C R + + P + P
Sbjct: 351 ----------QSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPE 400
Query: 922 TVAPPIHQGPAVPTAVIPLPPG 943
PP+ GP P V+P+PPG
Sbjct: 401 YPPPPL--GPIPP--VLPVPPG 418
Score = 44.7 bits (104), Expect = 6e-04
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
C+N H CS HA+C++ + C C GYTG+G C
Sbjct: 1367 CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1402
Score = 38.1 bits (87), Expect = 0.053
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
C H C HA C + A F CSC G+ G+G +C
Sbjct: 1326 CEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKC 1361
Score = 30.8 bits (68), Expect = 8.4
Identities = 11/23 (47%), Positives = 13/23 (56%)
Query: 1212 CSVNNGGCTHLCLATPGSRTCRC 1234
CS+ NGGC C + GS C C
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSC 1223
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 120 bits (302), Expect = 6e-27
Identities = 64/183 (34%), Positives = 99/183 (54%), Gaps = 2/183 (1%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD 1051
VYWTD +I RA L G T+I + P+ IAV+ + R+++WT + + IEV L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1052 GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111
T ++L D+ PR I G YW DW +NP+I+ + +D R+LV LG P
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNASLGWP 123
Query: 1112 NGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKM 1170
NGL D +L W DA T++ E ++ + R+ L + L + F T G +Y+T W+
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 1171 NSV 1173
+S+
Sbjct: 184 HSI 186
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 120 bits (302), Expect = 6e-27
Identities = 64/183 (34%), Positives = 99/183 (54%), Gaps = 2/183 (1%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD 1051
VYWTD +I RA L G T+I + P+ IAV+ + R+++WT + + IEV L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1052 GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111
T ++L D+ PR I G YW DW +NP+I+ + +D R+LV LG P
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNASLGWP 123
Query: 1112 NGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKM 1170
NGL D +L W DA T++ E ++ + R+ L + L + F T G +Y+T W+
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 1171 NSV 1173
+S+
Sbjct: 184 HSI 186
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 117 bits (292), Expect = 9e-26
Identities = 140/522 (26%), Positives = 193/522 (36%), Gaps = 106/522 (20%)
Query: 426 VAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLL 485
V G PQ G + G + + + NT + +++I +P VG +
Sbjct: 3203 VVRGEPQGSWGSMTG--VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMR 3260
Query: 486 PLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLV-IKQRFSGIDEHG 544
L I W A E NG S+TGG F +++ V F G L+ + Q G+D G
Sbjct: 3261 VLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFA--TGELLTMTQVARGLDPDG 3318
Query: 545 HLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRI 604
L +D + G VP+ + + ++ + E Y V T T+ G PS +
Sbjct: 3319 LLLLDVVVNGVVPESLADADLQVQDFEEHY-----VQTGPGQLFVGSTQRFFQGGLPSFL 3373
Query: 605 YTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGS 664
R + Q +P L Q L ++ ++ E + LR+ L+ ++
Sbjct: 3374 -----RCNHSIQYNAARGPQPQL--VQHLRASAISSAFDPEAEALRFQLATAL------- 3419
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGD--GRTCYDIDECSEQPSVCG 722
A +N +G C GF D G C D DECS PS C
Sbjct: 3420 -QAEENE--VG---------------------CPEGFELDSQGAFCVDRDECSGGPSPC- 3454
Query: 723 SHTICNNHPGTFRCECVEGYQFS-DEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
SH C N PG F C C G+ + D+ C R ++ C H C QR C+
Sbjct: 3455 SHA-CLNAPGRFSCTCPTGFALAWDDRNC------RDVDECAWDAHLCREGQR--CVNLL 3505
Query: 782 GSSYTC--SCLPGFS-GDGQACQDVDECQPSR--CHPDAFCYNTPGSFTCQCKPGYQGDG 836
GS Y C C PGF DG C+DVDEC CH + C NTPG C C GY+ G
Sbjct: 3506 GS-YRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQG 3564
Query: 837 FRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYC 896
P P L V EC QCH G
Sbjct: 3565 -------------------------------PSLPCLDVNECLQLPKACAYQCHNLQGSY 3593
Query: 897 WCVDRDGREVEGTRTRPGMTPPCL----STVAPPIHQGPAVP 934
C+ G+ T R G L V H+GP +P
Sbjct: 3594 RCLCPPGQ----TLLRDGKACTSLERNGQNVTTVSHRGPLLP 3631
Score = 70.9 bits (172), Expect = 7e-12
Identities = 49/181 (27%), Positives = 67/181 (37%), Gaps = 23/181 (12%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRT--CYDIDECSEQPSVCGSHTICNN 729
C G C N C P C C G+R G + C D++EC + P C C+N
Sbjct: 3532 CLEGLDDCHYNQLCENTPGGH-RCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 3588
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSY---- 785
G++RC C G +G +++ N +P G+SY
Sbjct: 3589 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3648
Query: 786 -------------TCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY 832
C PGF C D+DEC+ A C NT GS+ C C GY
Sbjct: 3649 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGY 3707
Query: 833 Q 833
+
Sbjct: 3708 R 3708
Score = 47.8 bits (112), Expect = 7e-05
Identities = 29/100 (29%), Positives = 41/100 (41%), Gaps = 17/100 (17%)
Query: 735 RCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794
R C G+ G C + + R N C+ N + SY C C G+
Sbjct: 3662 RAWCPPGF-IRQNGVCTDLDECRVRNLCQHACRNTE------------GSYQCLCPAGYR 3708
Query: 795 --GDGQACQDVDECQPS--RCHPDAFCYNTPGSFTCQCKP 830
G+ CQD++EC+ C P C+NT GS+ C P
Sbjct: 3709 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTP 3748
Score = 44.7 bits (104), Expect = 6e-04
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 7/73 (9%)
Query: 684 ACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
ACR + C C G+R G+ C DI+EC E+ CG +C N G+++C C
Sbjct: 3691 ACR-NTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPC 3749
Query: 739 VEGY-QFSDEGTC 750
Y Q GTC
Sbjct: 3750 PATYRQGPSPGTC 3762
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/76 (28%), Positives = 30/76 (39%), Gaps = 18/76 (23%)
Query: 1178 LAISKETDAFQPHKQTRLYGITTALSQ------CPQG------------HNYCSVNNGGC 1219
L S + AF P + + + TAL CP+G + CS C
Sbjct: 3395 LRASAISSAFDPEAEALRFQLATALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPC 3454
Query: 1220 THLCLATPGSRTCRCP 1235
+H CL PG +C CP
Sbjct: 3455 SHACLNAPGRFSCTCP 3470
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 117 bits (292), Expect = 9e-26
Identities = 140/522 (26%), Positives = 193/522 (36%), Gaps = 106/522 (20%)
Query: 426 VAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLL 485
V G PQ G + G + + + NT + +++I +P VG +
Sbjct: 4394 VVRGEPQGSWGSMTG--VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMR 4451
Query: 486 PLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLV-IKQRFSGIDEHG 544
L I W A E NG S+TGG F +++ V F G L+ + Q G+D G
Sbjct: 4452 VLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFA--TGELLTMTQVARGLDPDG 4509
Query: 545 HLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRI 604
L +D + G VP+ + + ++ + E Y V T T+ G PS +
Sbjct: 4510 LLLLDVVVNGVVPESLADADLQVQDFEEHY-----VQTGPGQLFVGSTQRFFQGGLPSFL 4564
Query: 605 YTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGS 664
R + Q +P L Q L ++ ++ E + LR+ L+ ++
Sbjct: 4565 -----RCNHSIQYNAARGPQPQL--VQHLRASAISSAFDPEAEALRFQLATAL------- 4610
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGD--GRTCYDIDECSEQPSVCG 722
A +N +G C GF D G C D DECS PS C
Sbjct: 4611 -QAEENE--VG---------------------CPEGFELDSQGAFCVDRDECSGGPSPC- 4645
Query: 723 SHTICNNHPGTFRCECVEGYQFS-DEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
SH C N PG F C C G+ + D+ C R ++ C H C QR C+
Sbjct: 4646 SHA-CLNAPGRFSCTCPTGFALAWDDRNC------RDVDECAWDAHLCREGQR--CVNLL 4696
Query: 782 GSSYTC--SCLPGFS-GDGQACQDVDECQPSR--CHPDAFCYNTPGSFTCQCKPGYQGDG 836
GS Y C C PGF DG C+DVDEC CH + C NTPG C C GY+ G
Sbjct: 4697 GS-YRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQG 4755
Query: 837 FRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYC 896
P P L V EC QCH G
Sbjct: 4756 -------------------------------PSLPCLDVNECLQLPKACAYQCHNLQGSY 4784
Query: 897 WCVDRDGREVEGTRTRPGMTPPCL----STVAPPIHQGPAVP 934
C+ G+ T R G L V H+GP +P
Sbjct: 4785 RCLCPPGQ----TLLRDGKACTSLERNGQNVTTVSHRGPLLP 4822
Score = 70.9 bits (172), Expect = 7e-12
Identities = 49/181 (27%), Positives = 67/181 (37%), Gaps = 23/181 (12%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRT--CYDIDECSEQPSVCGSHTICNN 729
C G C N C P C C G+R G + C D++EC + P C C+N
Sbjct: 4723 CLEGLDDCHYNQLCENTPGGH-RCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 4779
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSY---- 785
G++RC C G +G +++ N +P G+SY
Sbjct: 4780 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 4839
Query: 786 -------------TCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY 832
C PGF C D+DEC+ A C NT GS+ C C GY
Sbjct: 4840 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGY 4898
Query: 833 Q 833
+
Sbjct: 4899 R 4899
Score = 47.8 bits (112), Expect = 7e-05
Identities = 29/100 (29%), Positives = 41/100 (41%), Gaps = 17/100 (17%)
Query: 735 RCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794
R C G+ G C + + R N C+ N + SY C C G+
Sbjct: 4853 RAWCPPGF-IRQNGVCTDLDECRVRNLCQHACRNTE------------GSYQCLCPAGYR 4899
Query: 795 --GDGQACQDVDECQPS--RCHPDAFCYNTPGSFTCQCKP 830
G+ CQD++EC+ C P C+NT GS+ C P
Sbjct: 4900 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTP 4939
Score = 44.7 bits (104), Expect = 6e-04
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 7/73 (9%)
Query: 684 ACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
ACR + C C G+R G+ C DI+EC E+ CG +C N G+++C C
Sbjct: 4882 ACR-NTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPC 4940
Query: 739 VEGY-QFSDEGTC 750
Y Q GTC
Sbjct: 4941 PATYRQGPSPGTC 4953
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/76 (28%), Positives = 30/76 (39%), Gaps = 18/76 (23%)
Query: 1178 LAISKETDAFQPHKQTRLYGITTALSQ------CPQG------------HNYCSVNNGGC 1219
L S + AF P + + + TAL CP+G + CS C
Sbjct: 4586 LRASAISSAFDPEAEALRFQLATALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPC 4645
Query: 1220 THLCLATPGSRTCRCP 1235
+H CL PG +C CP
Sbjct: 4646 SHACLNAPGRFSCTCP 4661
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 117 bits (292), Expect = 9e-26
Identities = 140/522 (26%), Positives = 193/522 (36%), Gaps = 106/522 (20%)
Query: 426 VAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLL 485
V G PQ G + G + + + NT + +++I +P VG +
Sbjct: 3112 VVRGEPQGSWGSMTG--VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMR 3169
Query: 486 PLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLV-IKQRFSGIDEHG 544
L I W A E NG S+TGG F +++ V F G L+ + Q G+D G
Sbjct: 3170 VLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFA--TGELLTMTQVARGLDPDG 3227
Query: 545 HLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRI 604
L +D + G VP+ + + ++ + E Y V T T+ G PS +
Sbjct: 3228 LLLLDVVVNGVVPESLADADLQVQDFEEHY-----VQTGPGQLFVGSTQRFFQGGLPSFL 3282
Query: 605 YTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGS 664
R + Q +P L Q L ++ ++ E + LR+ L+ ++
Sbjct: 3283 -----RCNHSIQYNAARGPQPQL--VQHLRASAISSAFDPEAEALRFQLATAL------- 3328
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGD--GRTCYDIDECSEQPSVCG 722
A +N +G C GF D G C D DECS PS C
Sbjct: 3329 -QAEENE--VG---------------------CPEGFELDSQGAFCVDRDECSGGPSPC- 3363
Query: 723 SHTICNNHPGTFRCECVEGYQFS-DEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
SH C N PG F C C G+ + D+ C R ++ C H C QR C+
Sbjct: 3364 SHA-CLNAPGRFSCTCPTGFALAWDDRNC------RDVDECAWDAHLCREGQR--CVNLL 3414
Query: 782 GSSYTC--SCLPGFS-GDGQACQDVDECQPSR--CHPDAFCYNTPGSFTCQCKPGYQGDG 836
GS Y C C PGF DG C+DVDEC CH + C NTPG C C GY+ G
Sbjct: 3415 GS-YRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQG 3473
Query: 837 FRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYC 896
P P L V EC QCH G
Sbjct: 3474 -------------------------------PSLPCLDVNECLQLPKACAYQCHNLQGSY 3502
Query: 897 WCVDRDGREVEGTRTRPGMTPPCL----STVAPPIHQGPAVP 934
C+ G+ T R G L V H+GP +P
Sbjct: 3503 RCLCPPGQ----TLLRDGKACTSLERNGQNVTTVSHRGPLLP 3540
Score = 70.9 bits (172), Expect = 7e-12
Identities = 49/181 (27%), Positives = 67/181 (37%), Gaps = 23/181 (12%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRT--CYDIDECSEQPSVCGSHTICNN 729
C G C N C P C C G+R G + C D++EC + P C C+N
Sbjct: 3441 CLEGLDDCHYNQLCENTPGGH-RCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 3497
Query: 730 HPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSY---- 785
G++RC C G +G +++ N +P G+SY
Sbjct: 3498 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3557
Query: 786 -------------TCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY 832
C PGF C D+DEC+ A C NT GS+ C C GY
Sbjct: 3558 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGY 3616
Query: 833 Q 833
+
Sbjct: 3617 R 3617
Score = 47.8 bits (112), Expect = 7e-05
Identities = 29/100 (29%), Positives = 41/100 (41%), Gaps = 17/100 (17%)
Query: 735 RCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794
R C G+ G C + + R N C+ N + SY C C G+
Sbjct: 3571 RAWCPPGF-IRQNGVCTDLDECRVRNLCQHACRNTE------------GSYQCLCPAGYR 3617
Query: 795 --GDGQACQDVDECQPS--RCHPDAFCYNTPGSFTCQCKP 830
G+ CQD++EC+ C P C+NT GS+ C P
Sbjct: 3618 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTP 3657
Score = 44.7 bits (104), Expect = 6e-04
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 7/73 (9%)
Query: 684 ACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
ACR + C C G+R G+ C DI+EC E+ CG +C N G+++C C
Sbjct: 3600 ACR-NTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPC 3658
Query: 739 VEGY-QFSDEGTC 750
Y Q GTC
Sbjct: 3659 PATYRQGPSPGTC 3671
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/76 (28%), Positives = 30/76 (39%), Gaps = 18/76 (23%)
Query: 1178 LAISKETDAFQPHKQTRLYGITTALSQ------CPQG------------HNYCSVNNGGC 1219
L S + AF P + + + TAL CP+G + CS C
Sbjct: 3304 LRASAISSAFDPEAEALRFQLATALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPC 3363
Query: 1220 THLCLATPGSRTCRCP 1235
+H CL PG +C CP
Sbjct: 3364 SHACLNAPGRFSCTCP 3379
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 114 bits (286), Expect = 4e-25
Identities = 81/290 (27%), Positives = 129/290 (44%), Gaps = 23/290 (7%)
Query: 951 TGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG 1010
+G E+LPL G + + L FD +YW+D+ I R L+G
Sbjct: 776 SGATEQLPLTG---------------LRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGS 820
Query: 1011 E-PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN-PRG 1068
II L + E +A + L + ++W D+ +IEVA DG R + + +++ PR
Sbjct: 821 TGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRA 880
Query: 1069 IVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDA 1128
+V G ++WTDW P I S MDG+ LV +D+ PNG++ D + W DA
Sbjct: 881 LVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDA 938
Query: 1129 GTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ 1188
E + S R L+ L +P+A+ + +Y+ DW S+ + +
Sbjct: 939 YLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEIL- 997
Query: 1189 PHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCL-ATPGSRTCRCPDN 1237
++ T L + G N C C+ LCL SR+CRCP++
Sbjct: 998 ANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPED 1045
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 112 bits (281), Expect = 2e-24
Identities = 64/202 (31%), Positives = 94/202 (46%), Gaps = 47/202 (23%)
Query: 679 CDTNAACRPGPRTQFTCECSIGF---RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
C N+ C+ T+ TCEC G+ +GD C DIDEC+ + C ++T+C N PG +R
Sbjct: 401 CGENSECKNW-NTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYR 459
Query: 736 CECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG 795
C+CV GY D+ +C + C +G HNCD + A C T ++C+C PG+ G
Sbjct: 460 CDCVPGYIRVDDFSCT------EHDECGSGQHNCD--ENAICTNT-VQGHSCTCKPGYVG 510
Query: 796 DGQAC--------------------------------QDVDECQPS--RCHPDAFCYNTP 821
+G C +D+DEC CH + C N P
Sbjct: 511 NGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLP 570
Query: 822 GSFTCQCKPGYQGDGFRCVPGE 843
G + C+C+ G+ DG + GE
Sbjct: 571 GWYHCECRSGFHDDGTYSLSGE 592
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/76 (34%), Positives = 34/76 (44%), Gaps = 7/76 (9%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDG------RTCYDIDECSEQPSVCGSHT 725
C G C ++ C P + CEC GF DG +C DIDEC+ + C + +
Sbjct: 553 CSEGIIECHNHSRCVNLPGW-YHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDS 611
Query: 726 ICNNHPGTFRCECVEG 741
C N G F C C G
Sbjct: 612 ACINLAGGFDCLCPSG 627
Score = 40.4 bits (93), Expect = 0.011
Identities = 16/49 (32%), Positives = 23/49 (46%)
Query: 379 VFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVA 427
V ++ C + +H C +A C + G C+C GY GNG C A
Sbjct: 469 VDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRA 517
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 105 bits (263), Expect = 2e-22
Identities = 64/191 (33%), Positives = 91/191 (47%), Gaps = 22/191 (11%)
Query: 657 IGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF---------RGDGRT 707
I P R+ P+ N C T C A C + C C GF + G
Sbjct: 22 IRPTRK--PNTKGNNCRDSTL-CPAYATCT-NTVDSYYCACKQGFLSSNGQNHFKDPGVR 77
Query: 708 CYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLH 767
C DIDECS+ P CG ++ C N G ++C C++G+ T V +P N+ T ++
Sbjct: 78 CKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGF---SSPTGNDWVPGKPGNFSCTDIN 134
Query: 768 NC----DIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC-QPSRCHPDAFCYNTPG 822
C P+ + C+ + G SY+CSC GF C+DVDEC P C A C NT G
Sbjct: 135 ECLTSSVCPEHSDCVNSMG-SYSCSCQVGFISRNSTCEDVDECADPRACPEHATCNNTVG 193
Query: 823 SFTCQCKPGYQ 833
+++C C PG++
Sbjct: 194 NYSCFCNPGFE 204
Score = 94.4 bits (233), Expect = 6e-19
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 26/156 (16%)
Query: 693 FTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSD-----E 747
++C C +GF TC D+DEC++ P C H CNN G + C C G++ S +
Sbjct: 155 YSCSCQVGFISRNSTCEDVDECAD-PRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQ 213
Query: 748 GTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS---------GDGQ 798
G + D I+ C C P + C T GS Y C+C PGF+ G
Sbjct: 214 GLKASCED---IDECT---EMC--PINSTCTNTPGS-YFCTCHPGFAPSNGQLNFTDQGV 264
Query: 799 ACQDVDECQ--PSRCHPDAFCYNTPGSFTCQCKPGY 832
C+D+DEC+ PS C P++ C N GS++C C G+
Sbjct: 265 ECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGF 300
Score = 61.6 bits (148), Expect = 4e-09
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 17/104 (16%)
Query: 676 THGCDTNAACRPGPRTQFTCECSIGFR---------GDGRTCYDIDECSEQPSVCGSHTI 726
T C N+ C P + F C C GF G C DIDEC + PS CG ++I
Sbjct: 226 TEMCPINSTCTNTPGSYF-CTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSI 284
Query: 727 CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINY-CETGLHNC 769
C N G++ C C+ G+ + EG+ Q+ N+ C+ L C
Sbjct: 285 CTNALGSYSCGCIAGFHPNPEGS------QKDGNFSCQRVLFKC 322
Score = 56.6 bits (135), Expect = 1e-07
Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 47/193 (24%)
Query: 651 YALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--------- 701
Y+ S +G + S + C C +A C ++C C+ GF
Sbjct: 155 YSCSCQVGFISRNSTCEDVDEC-ADPRACPEHATCN-NTVGNYSCFCNPGFESSSGHLSF 212
Query: 702 RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGY-------QFSDEGTCVAVV 754
+G +C DIDEC+E +C ++ C N PG++ C C G+ F+D+G V
Sbjct: 213 QGLKASCEDIDECTE---MCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQG-----V 264
Query: 755 DQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPD 814
+ R I+ C C + C GS Y+C C+ GF HP+
Sbjct: 265 ECRDIDECRQDPSTCG--PNSICTNALGS-YSCGCIAGF------------------HPN 303
Query: 815 AFCYNTPGSFTCQ 827
G+F+CQ
Sbjct: 304 PEGSQKDGNFSCQ 316
Score = 53.9 bits (128), Expect = 9e-07
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 27/140 (19%)
Query: 719 SVCGSHTICNNHPGTFRCECVEGY-------QFSDEGTCVAVVDQRPINYCETGLHNCDI 771
++C ++ C N ++ C C +G+ F D G +D+ C C
Sbjct: 39 TLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDE-----CSQSPQPCG- 92
Query: 772 PQRAQCIYTGGSSYTCSCLPGFSGD-----------GQACQDVDECQPSRCHPD-AFCYN 819
+ C G Y CSCL GFS +C D++EC S P+ + C N
Sbjct: 93 -PNSSCKNLSGR-YKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVN 150
Query: 820 TPGSFTCQCKPGYQGDGFRC 839
+ GS++C C+ G+ C
Sbjct: 151 SMGSYSCSCQVGFISRNSTC 170
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 104 bits (260), Expect = 5e-22
Identities = 65/204 (31%), Positives = 86/204 (42%), Gaps = 47/204 (23%)
Query: 677 HGCDTNAACRPGPRTQFTCECSIGFRG---DGRTCYDIDECSEQPSVCGSHTICNNHPGT 733
H C N+ CR + C C GFR D C DIDEC+E C +T+C N PG+
Sbjct: 428 HNCMENSICR-NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGS 486
Query: 734 FRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF 793
F C C GY D+ +C + C T HNCD + A C T G + C C PG+
Sbjct: 487 FMCICKTGYIRIDDYSCTEHDE------CITNQHNCD--ENALCFNTVGG-HNCVCKPGY 537
Query: 794 SGDGQACQ--------------------------------DVDECQPS--RCHPDAFCYN 819
+G+G C+ D+DEC +C A C N
Sbjct: 538 TGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCIN 597
Query: 820 TPGSFTCQCKPGYQGDGFRCVPGE 843
PG + C+C+ GY +G GE
Sbjct: 598 LPGWYHCECRDGYHDNGMFSPSGE 621
Score = 87.0 bits (214), Expect = 1e-16
Identities = 69/254 (27%), Positives = 94/254 (37%), Gaps = 50/254 (19%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGF-RGDGRTCYDIDECSEQPSVCGSHTICNNH 730
C G H C N C P + F C C G+ R D +C + DEC C + +C N
Sbjct: 467 CAEGRHYCRENTMCVNTPGS-FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNT 525
Query: 731 PGTFRCECVEGYQFS-------------DEGTCVAV------------VDQRPINYCETG 765
G C C GY + + G C+A + I+ C G
Sbjct: 526 VGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDG 585
Query: 766 LHNCDIPQRAQCIYTGGSSYTCSCLPG------FSGDGQACQDVDECQPSR--CHPDAFC 817
CD RA CI G Y C C G FS G++C+D+DEC R C D C
Sbjct: 586 FVQCD--SRANCINLPGW-YHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTIC 642
Query: 818 YNTPGSFTCQCKPGYQGDGFRCVPGEVEK------------TRCQHEREHILGAAGATDP 865
+N G + C+C G G G+V+ + C + ++ D
Sbjct: 643 FNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDC 702
Query: 866 QRPIPPGLFVPECD 879
+ P PECD
Sbjct: 703 ENPTVDLFCCPECD 716
Score = 77.0 bits (188), Expect = 1e-13
Identities = 45/137 (32%), Positives = 65/137 (47%), Gaps = 11/137 (8%)
Query: 706 RTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETG 765
+ C D CSE+ + C ++IC N C C +G++ E I+ C G
Sbjct: 416 KVCKGYDFCSERHN-CMENSICRNLNDRAVCSCRDGFRALREDNAYC----EDIDECAEG 470
Query: 766 LHNCDIPQRAQCIYTGGSSYTCSCLPGFSG-DGQACQDVDECQPSR--CHPDAFCYNTPG 822
H C + C+ T GS + C C G+ D +C + DEC ++ C +A C+NT G
Sbjct: 471 RHYCR--ENTMCVNTPGS-FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVG 527
Query: 823 SFTCQCKPGYQGDGFRC 839
C CKPGY G+G C
Sbjct: 528 GHNCVCKPGYTGNGTTC 544
Score = 43.1 bits (100), Expect = 0.002
Identities = 18/46 (39%), Positives = 22/46 (47%)
Query: 382 YNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVA 427
Y+ C N+H C +A C + G C C GYTGNG C A
Sbjct: 501 YSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA 546
Score = 34.7 bits (78), Expect = 0.58
Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 7/66 (10%)
Query: 1177 DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
D A+ D F+ ++ Y + +C +G +YC N +C+ TPGS C C
Sbjct: 441 DRAVCSCRDGFRALREDNAY--CEDIDECAEGRHYCRENT-----MCVNTPGSFMCICKT 493
Query: 1237 NTLGVD 1242
+ +D
Sbjct: 494 GYIRID 499
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 104 bits (260), Expect = 5e-22
Identities = 65/204 (31%), Positives = 86/204 (42%), Gaps = 47/204 (23%)
Query: 677 HGCDTNAACRPGPRTQFTCECSIGFRG---DGRTCYDIDECSEQPSVCGSHTICNNHPGT 733
H C N+ CR + C C GFR D C DIDEC+E C +T+C N PG+
Sbjct: 404 HNCMENSICR-NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGS 462
Query: 734 FRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF 793
F C C GY D+ +C + C T HNCD + A C T G + C C PG+
Sbjct: 463 FMCICKTGYIRIDDYSCTEHDE------CITNQHNCD--ENALCFNTVGG-HNCVCKPGY 513
Query: 794 SGDGQACQ--------------------------------DVDECQPS--RCHPDAFCYN 819
+G+G C+ D+DEC +C A C N
Sbjct: 514 TGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCIN 573
Query: 820 TPGSFTCQCKPGYQGDGFRCVPGE 843
PG + C+C+ GY +G GE
Sbjct: 574 LPGWYHCECRDGYHDNGMFSPSGE 597
Score = 87.0 bits (214), Expect = 1e-16
Identities = 69/254 (27%), Positives = 94/254 (37%), Gaps = 50/254 (19%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGF-RGDGRTCYDIDECSEQPSVCGSHTICNNH 730
C G H C N C P + F C C G+ R D +C + DEC C + +C N
Sbjct: 443 CAEGRHYCRENTMCVNTPGS-FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNT 501
Query: 731 PGTFRCECVEGYQFS-------------DEGTCVAV------------VDQRPINYCETG 765
G C C GY + + G C+A + I+ C G
Sbjct: 502 VGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDG 561
Query: 766 LHNCDIPQRAQCIYTGGSSYTCSCLPG------FSGDGQACQDVDECQPSR--CHPDAFC 817
CD RA CI G Y C C G FS G++C+D+DEC R C D C
Sbjct: 562 FVQCD--SRANCINLPGW-YHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTIC 618
Query: 818 YNTPGSFTCQCKPGYQGDGFRCVPGEVEK------------TRCQHEREHILGAAGATDP 865
+N G + C+C G G G+V+ + C + ++ D
Sbjct: 619 FNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDC 678
Query: 866 QRPIPPGLFVPECD 879
+ P PECD
Sbjct: 679 ENPTVDLFCCPECD 692
Score = 77.0 bits (188), Expect = 1e-13
Identities = 45/137 (32%), Positives = 65/137 (47%), Gaps = 11/137 (8%)
Query: 706 RTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETG 765
+ C D CSE+ + C ++IC N C C +G++ E I+ C G
Sbjct: 392 KVCKGYDFCSERHN-CMENSICRNLNDRAVCSCRDGFRALREDNAYC----EDIDECAEG 446
Query: 766 LHNCDIPQRAQCIYTGGSSYTCSCLPGFSG-DGQACQDVDECQPSR--CHPDAFCYNTPG 822
H C + C+ T GS + C C G+ D +C + DEC ++ C +A C+NT G
Sbjct: 447 RHYCR--ENTMCVNTPGS-FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVG 503
Query: 823 SFTCQCKPGYQGDGFRC 839
C CKPGY G+G C
Sbjct: 504 GHNCVCKPGYTGNGTTC 520
Score = 43.1 bits (100), Expect = 0.002
Identities = 18/46 (39%), Positives = 22/46 (47%)
Query: 382 YNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVA 427
Y+ C N+H C +A C + G C C GYTGNG C A
Sbjct: 477 YSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA 522
Score = 34.7 bits (78), Expect = 0.58
Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 7/66 (10%)
Query: 1177 DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
D A+ D F+ ++ Y + +C +G +YC N +C+ TPGS C C
Sbjct: 417 DRAVCSCRDGFRALREDNAY--CEDIDECAEGRHYCRENT-----MCVNTPGSFMCICKT 469
Query: 1237 NTLGVD 1242
+ +D
Sbjct: 470 GYIRID 475
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,662,377
Number of Sequences: 37866
Number of extensions: 2994999
Number of successful extensions: 12729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 7400
Number of HSP's gapped (non-prelim): 2712
length of query: 1247
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1133
effective length of database: 13,930,794
effective search space: 15783589602
effective search space used: 15783589602
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.