BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] (421 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 850 0.0 gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 850 0.0 gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 850 0.0 gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 850 0.0 gi|114796646 regulator of chromosome condensation 1 isoform b [H... 840 0.0 gi|114796644 regulator of chromosome condensation 1 isoform a [H... 834 0.0 gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 142 6e-34 gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 142 6e-34 gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 136 4e-32 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 136 4e-32 gi|7657152 hect domain and RLD 3 [Homo sapiens] 132 6e-31 gi|126032348 hect domain and RLD 2 [Homo sapiens] 124 2e-28 gi|222136641 NIMA-related kinase 9 [Homo sapiens] 109 4e-24 gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22 gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22 gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 100 3e-21 gi|61563742 hect domain and RLD 6 [Homo sapiens] 98 2e-20 gi|6912330 deafness locus associated putative guanine nucleotide... 97 4e-20 gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 89 6e-18 gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 87 2e-17 gi|4557445 regulator of chromosome condensation and BTB domain c... 83 4e-16 gi|30039692 NIMA-related kinase 8 [Homo sapiens] 81 2e-15 gi|110825982 hect domain and RLD 5 [Homo sapiens] 80 3e-15 gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12 gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12 gi|63054860 RCC1 domain containing 1 [Homo sapiens] 69 1e-11 gi|63054858 RCC1 domain containing 1 [Homo sapiens] 69 1e-11 gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 3e-09 gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 60 4e-09 gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 4e-09 >gi|4502801 regulator of chromosome condensation 1 isoform c [Homo sapiens] Length = 421 Score = 850 bits (2197), Expect = 0.0 Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 850 bits (2197), Expect = 0.0 Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 850 bits (2197), Expect = 0.0 Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 850 bits (2197), Expect = 0.0 Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >gi|114796646 regulator of chromosome condensation 1 isoform b [Homo sapiens] Length = 438 Score = 840 bits (2169), Expect = 0.0 Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43 MSPKRIAKRRSPPADAIPKSKKVK VSHRSHSTEPGLVLTLGQG Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60 Query: 44 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT Sbjct: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120 Query: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM Sbjct: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180 Query: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL Sbjct: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240 Query: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP Sbjct: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300 Query: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR Sbjct: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360 Query: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS Sbjct: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420 Query: 404 VSSGGQHTVLLVKDKEQS 421 VSSGGQHTVLLVKDKEQS Sbjct: 421 VSSGGQHTVLLVKDKEQS 438 >gi|114796644 regulator of chromosome condensation 1 isoform a [Homo sapiens] Length = 452 Score = 834 bits (2155), Expect = 0.0 Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29 MSPKRIAKRRSPPADAIPKSKKVK VSHRS Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60 Query: 30 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY Sbjct: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120 Query: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN Sbjct: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180 Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE Sbjct: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240 Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY Sbjct: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300 Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG Sbjct: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360 Query: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV Sbjct: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420 Query: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS Sbjct: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452 >gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] Length = 1049 Score = 142 bits (358), Expect = 6e-34 Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%) Query: 37 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92 +L G GQLGLG E V+E +K I + V G HTV + G VY+ G Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59 Query: 93 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151 CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114 Query: 152 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209 +GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG + Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174 Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269 + Q L+ LL + F G +F ++ G ++G+G + + Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219 Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329 QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277 Query: 330 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 386 + E + P + L V+ +ACG A V GR++++G+G N QLGTG + Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336 Query: 387 SPVEMMG 393 SP + G Sbjct: 337 SPFTVKG 343 Score = 120 bits (300), Expect = 3e-27 Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84 H + G V T G D+GQLG + RKKP V +++V G HT+ L+ Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101 Query: 85 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 143 GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+ VF W Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161 Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201 G ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G + Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219 Query: 202 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261 GQLG E VP +LKS S+ V CG T A++ EG V Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263 Query: 262 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321 + FG Y QLG T P+ + S + + G QH + + S G+ YS G Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322 Query: 322 EYGRLGLGEGAEEKS 336 G+LG G + KS Sbjct: 323 GNGQLGTGSTSNRKS 337 Score = 104 bits (259), Expect = 2e-22 Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%) Query: 155 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 214 +LEP K ++ V V G H V + DG +YT GC + GQLG Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69 Query: 215 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 268 KSR V DA CG T A++ +G VY +GL + Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112 Query: 269 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327 QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170 Query: 328 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385 LG ++++ P L+ L + VA G + + +T G +F WG QLG + D Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230 Query: 386 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 + P + K L ++ ++ + G HT L K+ Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260 >gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] Length = 1057 Score = 142 bits (358), Expect = 6e-34 Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%) Query: 37 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92 +L G GQLGLG E V+E +K I + V G HTV + G VY+ G Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59 Query: 93 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151 CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114 Query: 152 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209 +GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG + Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174 Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269 + Q L+ LL + F G +F ++ G ++G+G + + Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219 Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329 QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277 Query: 330 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 386 + E + P + L V+ +ACG A V GR++++G+G N QLGTG + Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336 Query: 387 SPVEMMG 393 SP + G Sbjct: 337 SPFTVKG 343 Score = 120 bits (300), Expect = 3e-27 Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84 H + G V T G D+GQLG + RKKP V +++V G HT+ L+ Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101 Query: 85 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 143 GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+ VF W Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161 Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201 G ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G + Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219 Query: 202 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261 GQLG E VP +LKS S+ V CG T A++ EG V Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263 Query: 262 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321 + FG Y QLG T P+ + S + + G QH + + S G+ YS G Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322 Query: 322 EYGRLGLGEGAEEKS 336 G+LG G + KS Sbjct: 323 GNGQLGTGSTSNRKS 337 Score = 104 bits (259), Expect = 2e-22 Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%) Query: 155 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 214 +LEP K ++ V V G H V + DG +YT GC + GQLG Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69 Query: 215 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 268 KSR V DA CG T A++ +G VY +GL + Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112 Query: 269 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327 QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170 Query: 328 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385 LG ++++ P L+ L + VA G + + +T G +F WG QLG + D Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230 Query: 386 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 + P + K L ++ ++ + G HT L K+ Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260 >gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo sapiens] Length = 815 Score = 136 bits (342), Expect = 4e-32 Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85 H + T + G + GQLGLG K + ++ PE V A G HT+ ++ Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105 Query: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144 G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165 Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204 ++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222 Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264 G +L N Q + +P+ V+ CG T ++ E VY F Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266 Query: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322 GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323 Query: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353 +G+LGLG E IPTL S V VACG Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357 Score = 89.0 bits (219), Expect = 7e-18 Identities = 88/301 (29%), Positives = 139/301 (46%), Gaps = 34/301 (11%) Query: 18 PKSKKVKVSHRSH---STEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQ 71 P+ K+ R+H STE G V G + GQLGLG+ ER ++S + Q Sbjct: 86 PEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQ 144 Query: 72 AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHT 131 AG + L++ G+++ +G N EG +G + VP +V + + V +S G H+ Sbjct: 145 LSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHS 202 Query: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTA 189 A +T DG ++++G NG +GL + + Q+ ++P V++VA G +H V+LT Sbjct: 203 AFVTTDGELYVFG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT- 259 Query: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249 + +YT G G+ GQLG LF PK + + ++ CG Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGE 304 Query: 250 YFTFAISHEGHVYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHT 306 T I+ G +Y FG + +LG G E+ FIP ++F V GG H Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMV 362 Query: 307 V 307 V Sbjct: 363 V 363 Score = 75.9 bits (185), Expect = 7e-14 Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%) Query: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191 + D G VF +G F +NN P K + DVPV ++ G++H ++T + Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54 Query: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250 LY G GQLG G + + + P CV LK + + A CG Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97 Query: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308 T + G+VY G +N QLG TE + F ++ SF S S G + + Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154 Query: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368 + +G+ + G G++GL + +P ++ VS ++CG VT DG ++ Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213 Query: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417 +G N +LG P +++G QL + + V+ V+ GG+HTV+L ++ Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 136 bits (342), Expect = 4e-32 Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85 H + T + G + GQLGLG K + ++ PE V A G HT+ ++ Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105 Query: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144 G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165 Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204 ++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222 Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264 G +L N Q + +P+ V+ CG T ++ E VY F Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266 Query: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322 GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323 Query: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353 +G+LGLG E IPTL S V VACG Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357 Score = 89.0 bits (219), Expect = 7e-18 Identities = 88/301 (29%), Positives = 139/301 (46%), Gaps = 34/301 (11%) Query: 18 PKSKKVKVSHRSH---STEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQ 71 P+ K+ R+H STE G V G + GQLGLG+ ER ++S + Q Sbjct: 86 PEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQ 144 Query: 72 AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHT 131 AG + L++ G+++ +G N EG +G + VP +V + + V +S G H+ Sbjct: 145 LSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHS 202 Query: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTA 189 A +T DG ++++G NG +GL + + Q+ ++P V++VA G +H V+LT Sbjct: 203 AFVTTDGELYVFG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT- 259 Query: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249 + +YT G G+ GQLG LF PK + + ++ CG Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGE 304 Query: 250 YFTFAISHEGHVYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHT 306 T I+ G +Y FG + +LG G E+ FIP ++F V GG H Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMV 362 Query: 307 V 307 V Sbjct: 363 V 363 Score = 75.9 bits (185), Expect = 7e-14 Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%) Query: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191 + D G VF +G F +NN P K + DVPV ++ G++H ++T + Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54 Query: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250 LY G GQLG G + + + P CV LK + + A CG Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97 Query: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308 T + G+VY G +N QLG TE + F ++ SF S S G + + Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154 Query: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368 + +G+ + G G++GL + +P ++ VS ++CG VT DG ++ Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213 Query: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417 +G N +LG P +++G QL + + V+ V+ GG+HTV+L ++ Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261 >gi|7657152 hect domain and RLD 3 [Homo sapiens] Length = 1050 Score = 132 bits (332), Expect = 6e-31 Identities = 113/404 (27%), Positives = 184/404 (45%), Gaps = 43/404 (10%) Query: 37 VLTLGQGDVGQLGLGEN----VMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92 +L G +GQ G+ N V E + +S V + GG H+V L + G+VY+ G Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFIS-DRSVKEVACGGNHSVFLLEDGEVYTCG 59 Query: 93 CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152 N +G LG + E + + + ++ V+ G+SH+ AL+D G++F WG+ D G Sbjct: 60 LNTKGQLGHEREGNKPEQIGALAD--QHIIHVACGESHSLALSDRGQLFSWGAGSD--GQ 115 Query: 153 IGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPEL 210 +GL+ VP +Q +++V+ GN H + L ADG +T G GQLG E Sbjct: 116 LGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE- 174 Query: 211 FANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYH 270 F ++ Q + R G Q A GA+ +FA+S G V+G+G++N Sbjct: 175 FPSQASPQ-------------RVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWGMNNAG 220 Query: 271 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 330 QLG + P ++ + T+ V S G+ HT + G ++ G G+LG Sbjct: 221 QLGLSDEKDRESPCHVKLLR--TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278 Query: 331 GAEEKSIPTLISRLPA-VSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388 +E + ++ + + V+ +ACG A V G ++A+G G QLGTG + P Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338 Query: 389 VEMMG-------------KQLENRVVLSVSSGGQHTVLLVKDKE 419 + G + + +V + SGG T +L E Sbjct: 339 SPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYE 382 Score = 106 bits (264), Expect = 5e-23 Identities = 89/316 (28%), Positives = 138/316 (43%), Gaps = 29/316 (9%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLS 83 +H E G V T G GQLG + E KP + D ++ G H++ LS Sbjct: 44 NHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGALADQHIIHVACGESHSLALS 100 Query: 84 KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVF 141 GQ++S+G +G LG T+ E S VP ++ Q+ ++QVS G+ H AL DG+ F Sbjct: 101 DRGQLFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 159 Query: 142 LWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCG 199 WG ++++G +GL + P +V+ +P+ +VA+G H L+ G ++ G Sbjct: 160 TWG--KNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMN 217 Query: 200 EQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEG 259 GQLG E +R ++ L K V + CG T ++ G Sbjct: 218 NAGQLGLSDE--KDRESPCHVKLLRTQKVVYIS--------------CGEEHTAVLTKSG 261 Query: 260 HVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLG 319 V+ FG + QLG P+ + S + + G QH + S G Y+ G Sbjct: 262 GVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA-CGRQHTLAFVPSSGLIYAFG 320 Query: 320 RAEYGRLGLGEGAEEK 335 G+LG G K Sbjct: 321 CGARGQLGTGHTCNVK 336 >gi|126032348 hect domain and RLD 2 [Homo sapiens] Length = 4834 Score = 124 bits (311), Expect = 2e-28 Identities = 93/303 (30%), Positives = 144/303 (47%), Gaps = 30/303 (9%) Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 V Q++ + L+ +GRV+ D L P VQ +VK+A+ Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDT------LAPQL-----VQGLASRNIVKIAAH 501 Query: 181 ND--HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 238 +D H + L A G++Y+ GCG+ G+LG G LE PK + S G + Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH--------GDTVPLEE---PKVISAFS-GKQA 549 Query: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 298 CG+ ++ AI+ EG +Y +G NY +LG +E IP + K V Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609 Query: 299 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASV 356 G T+ + G+ +S G +YG+LG G G++ P LI +L V V CG+ Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRG-GSDGCKTPKLIEKLQDLDVVKVRCGSQF 668 Query: 357 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416 A+TKDG+V++WG G N +LG G +E P + G L+ + V+ V++G H + L + Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--LQGKKVIDVAAGSTHCLALTE 726 Query: 417 DKE 419 D E Sbjct: 727 DSE 729 Score = 122 bits (307), Expect = 5e-28 Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 28/347 (8%) Query: 79 TVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM---VPGKVELQEKVVQVSAGDSHTAALT 135 T+ SG +Y +G N G LG +EG+++ P + + VQ+ G+ A+T Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001 Query: 136 DDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-LDVPVVKVASGNDHLVMLTADGDLY 194 DG+++ G IG E + + +Q + + V V SG H + L+++G++Y Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061 Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254 + G E G+LG G R +R P+ + RG + D G + Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDR---PRVI----ESLRG-IEVVDVAAGGAHSAC 4105 Query: 255 ISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK 314 ++ G +Y +G Y +LG +E P+ + + + + G T+C+ + Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165 Query: 315 AYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMG 372 +S G +YG+LG G G++ +P I L V V CG+ A+TK G V+ WG G Sbjct: 4166 VWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224 Query: 373 TNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419 ++LG G D+ P ++ G L+ + V+++++G H V +D E Sbjct: 4225 DYHRLGHGSDDHVRRPRQVQG--LQGKKVIAIATGSLHCVCCTEDGE 4269 Score = 120 bits (302), Expect = 2e-27 Identities = 104/364 (28%), Positives = 170/364 (46%), Gaps = 41/364 (11%) Query: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM-VPGKVELQE--KVVQVS 125 +++ +A G+ + ++ +V+ +G ND+ LG ++GS++ VP E VVQV+ Sbjct: 2943 LIRKKAAGLESAATIRT-KVFVWGLNDKDQLG---GLKGSKIKVPSFSETLSALNVVQVA 2998 Query: 126 AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD------VPVVKVAS 179 G A+T +G+V+ G NG +GL + VP+ Q+ V V V S Sbjct: 2999 GGSKSLFAVTVEGKVYACGEA--TNGRLGL--GISSGTVPIPRQITALSSYVVKKVAVHS 3054 Query: 180 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCV-MLKSRGSRG 238 G H LT DG +++ G G+ G+LG + ++ P+ + LK++ Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-----------PRLIEALKTK---- 3099 Query: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 298 R +D CG+ + A++ G +Y +GL Y +LG + P+ + V Sbjct: 3100 --RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVA 3157 Query: 299 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASV 356 T+ + EG +S G ++G+LG G G+E +IP I RL V + CGA Sbjct: 3158 CGSRDAQTLALTDEGLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQF 3216 Query: 357 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416 A+TK G V+ WG G ++LG G D P + G L + ++ V+ G H L V Sbjct: 3217 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG--LRGKKIVHVAVGALH-CLAVT 3273 Query: 417 DKEQ 420 D Q Sbjct: 3274 DSGQ 3277 Score = 120 bits (301), Expect = 2e-27 Identities = 115/387 (29%), Positives = 168/387 (43%), Gaps = 36/387 (9%) Query: 37 VLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLSKSGQVYSFGCN 94 V G D QLG G + K P+ +VVQ G ++ G+VY+ G Sbjct: 2961 VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019 Query: 95 DEGALGRDTSVEGSEMVPGKVELQE----KVVQVSAGDSHTAALTDDGRVFLWGSFRDNN 150 G LG S G+ +P ++ K V V +G H ALT DG+VF WG D Sbjct: 3020 TNGRLGLGIS-SGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD-- 3076 Query: 151 GVIGLLEPMKKSMVPVQVQLDVPVVK-VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209 G +G M + L ++ +A G+ H LT+ G+LYT G GE G+LG Sbjct: 3077 GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN 3136 Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF--TFAISHEGHVYGFGLS 267 L PK V + GH Q A CG+ T A++ EG V+ +G Sbjct: 3137 TTQ-----------LKPKMVKVLL----GHRVIQVA-CGSRDAQTLALTDEGLVFSWGDG 3180 Query: 268 NYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327 ++ +LG G+E C IPQN+ + G ++ + G ++ G+ +Y RLG Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFSLALTKSGVVWTWGKGDYFRLG 3238 Query: 328 LGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385 G + P ++ L + VA GA AVT G+V+AWG + Q G G Sbjct: 3239 HGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3297 Query: 386 WSPVEMMGKQLENRVVLSVSSGGQHTV 412 P + G LE + + V+ G H+V Sbjct: 3298 RKPTLVQG--LEGQKITRVACGSSHSV 3322 Score = 114 bits (284), Expect = 2e-25 Identities = 110/398 (27%), Positives = 162/398 (40%), Gaps = 37/398 (9%) Query: 35 GLVLTLGQGDVGQLGLGENVMER-KKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGC 93 G + G GQLG E + P VQ G ++ G++Y+ G Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011 Query: 94 NDEGALGRDTSVEGSEMVPGKVELQE------KVVQVSAGDSHTAALTDDGRVFLWGSFR 147 G LG + G+E V L+ K V V++G H AL+ +G V+ WG Sbjct: 4012 GAGGRLG----IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067 Query: 148 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRV 207 D G P + V ++ + VV VA+G H +TA GDLYT G G G+LG Sbjct: 4068 DGKLGHGNRSPCDRPRV-IESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126 Query: 208 PELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA--YFTFAISHEGHVYGFG 265 E L PK V +GH R D CG+ T ++ + V+ +G Sbjct: 4127 DS-----------EDQLKPKLV----EALQGH-RVVDIACGSGDAQTLCLTDDDTVWSWG 4170 Query: 266 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325 +Y +LG G++ C +P + S V G +V + G Y+ G+ +Y R Sbjct: 4171 DGDYGKLGRGGSDGCKVPMKIDSLTGL--GVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228 Query: 326 LGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE 383 LG G + P + L V ++A G+ T+DG V+ WG QLG G Sbjct: 4229 LGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287 Query: 384 DAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421 P + L+ + V V+ G HT+ K S Sbjct: 4288 AIQRP--RLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323 Score = 108 bits (270), Expect = 9e-24 Identities = 95/332 (28%), Positives = 152/332 (45%), Gaps = 29/332 (8%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEA---GGMHTVCLSKSGQV 88 T G + G G G+LG+G L SI ++ A GG H + LS G+V Sbjct: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060 Query: 89 YSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLWGSF 146 YS+G ++G LG P +E +VV V+AG +H+A +T G ++ WG Sbjct: 4061 YSWGEAEDGKLGHGNRSPCDR--PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4118 Query: 147 RDNN-GVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205 R G + +K +V V + SG+ + LT D +++ G G+ G+LG Sbjct: 4119 RYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4178 Query: 206 RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 265 R GG G + VP + + S G V+ + CG+ F+ A++ G VY +G Sbjct: 4179 R--------GGSDGCK---VP--MKIDSLTGLGVVKVE---CGSQFSVALTKSGAVYTWG 4222 Query: 266 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325 +YH+LG + P+ + + K + + G H VC +G+ Y+ G + G+ Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQG--KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280 Query: 326 LGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355 LG G P L++ L V+ VACG++ Sbjct: 4281 LGDGT-TNAIQRPRLVAALQGKKVNRVACGSA 4311 Score = 103 bits (257), Expect = 3e-22 Identities = 94/342 (27%), Positives = 157/342 (45%), Gaps = 36/342 (10%) Query: 32 TEPGLVLTLGQGDVGQLGLGENV----MERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 87 T G V G+ G+LGLG + + R+ AL S V +GG H L+ G+ Sbjct: 3008 TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK 3067 Query: 88 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFR 147 V+S+G D+G LG + + + + +++ ++ G SH+AALT G ++ WG Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGL-- 3125 Query: 148 DNNGVIGLL------EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201 G G L +K MV V + V V S + + LT +G +++ G G+ Sbjct: 3126 ---GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182 Query: 202 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261 G+LG RGG +G +P+ ++ +G + + CGA F+ A++ G V Sbjct: 3183 GKLG--------RGGSEGCN---IPQ--NIERLNGQGVCQIE---CGAQFSLALTKSGVV 3226 Query: 262 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321 + +G +Y +LG PQ + + K V + G H + + G+ Y+ G Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRG--KKIVHVAVGALHCLAVTDSGQVYAWGDN 3284 Query: 322 EYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVT 361 ++G+ G G + PTL+ L ++ VACG+S A T Sbjct: 3285 DHGQQGNGTTTVNRK-PTLVQGLEGQKITRVACGSSHSVAWT 3325 Score = 89.7 bits (221), Expect = 4e-18 Identities = 82/322 (25%), Positives = 148/322 (45%), Gaps = 47/322 (14%) Query: 70 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE-----MVPGKVELQEKVVQV 124 + A + G H + L+ +G+VYS+GC D G LG +V E GK + + VV + Sbjct: 498 IAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGK-QAGKHVVHI 556 Query: 125 SAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ----LDVPVVKVASG 180 + G +++AA+T +G ++ WG R N G +G + +P+ V L V V SG Sbjct: 557 ACGSTYSAAITAEGELYTWG--RGNYGRLG-HGSSEDEAIPMLVAGLKGLKVIDVACGSG 613 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 + + +T +G +++ G G+ G+LG RGG G + PK + V Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLG--------RGGSDGCK---TPKLIEKLQDLDVVKV 662 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 R CG+ F+ A++ +G VY +G + +LG E P+ L + K + + Sbjct: 663 R-----CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQG--KKVIDVA 715 Query: 301 GGQHHTVCMDSEGKAYSLGRAE----YGRLGLGEGAEEKSIPTLISRLPAVSSVACGASV 356 G H + + + + +S G + + L + + E ++P L ++ + +ACG + Sbjct: 716 AGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK-PEPAALPGLDTK--HIVGIACGPA- 771 Query: 357 GYAVTKDGRVFAWGMGTNYQLG 378 + FAW + + +G Sbjct: 772 --------QSFAWSSCSEWSIG 785 Score = 79.0 bits (193), Expect = 8e-15 Identities = 67/239 (28%), Positives = 98/239 (41%), Gaps = 19/239 (7%) Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 +D + G +Y G +GQLG G +G + + C L + + Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG----------GIEGAKVKVPTPCEALAT------L 3985 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 R G FA++ +G +Y G +LG GTES P L S ++ V + Sbjct: 3986 RPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVN 4045 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGY 358 G H + + SEG+ YS G AE G+LG G P +I L + VA G + Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIESLRGIEVVDVAAGGAHSA 4104 Query: 359 AVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 VT G ++ WG G +LG ED P + Q V ++ SG T+ L D Sbjct: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163 Score = 76.3 bits (186), Expect = 5e-14 Identities = 85/314 (27%), Positives = 139/314 (44%), Gaps = 41/314 (13%) Query: 21 KKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPE-DVVQAEAG 75 KKV V+ H + G V + G+ + G+LG G + + S+ +VV AG Sbjct: 4040 KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4099 Query: 76 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVS--AGDSHT 131 G H+ C++ +G +Y++G G LG S + ++ P VE + +VV ++ +GD+ T Sbjct: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSED--QLKPKLVEALQGHRVVDIACGSGDAQT 4157 Query: 132 AALTDDGRVFLWG----SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVML 187 LTDD V+ WG G G PMK + + VVKV G+ V L Sbjct: 4158 LCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMK-----IDSLTGLGVVKVECGSQFSVAL 4212 Query: 188 TADGDLYTLGCGEQGQLGRVPELFANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAF 246 T G +YT G G+ +LG + R + QGL+ K + + + Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQG---KKVIAIAT------------- 4256 Query: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306 G+ + +G VY +G ++ QLG T + P+ + + + + V + G HT Sbjct: 4257 -GSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV--ACGSAHT 4313 Query: 307 VCMDSEGKAYSLGR 320 + S K S G+ Sbjct: 4314 LAW-STSKPASAGK 4326 Score = 75.9 bits (185), Expect = 7e-14 Identities = 75/269 (27%), Positives = 119/269 (44%), Gaps = 34/269 (12%) Query: 21 KKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEA 74 KKV V H + T G V + G+GD G+LG M KP L+ + + Sbjct: 3048 KKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSR-MNCDKPRLIEALKTKRIRDIAC 3106 Query: 75 GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAG--DSHTA 132 G H+ L+ SG++Y++G + G LG + + KV L +V+QV+ G D+ T Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTL 3166 Query: 133 ALTDDGRVFLWGSFRDNNGVIGLL--EPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLT 188 ALTD+G VF WG +G G L + +P ++ V ++ G + LT Sbjct: 3167 ALTDEGLVFSWG-----DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221 Query: 189 ADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 248 G ++T G G+ +LG ++ + P+ V G RG + G Sbjct: 3222 KSGVVWTWGKGDYFRLGHGSDVHVRK-----------PQVV----EGLRGK-KIVHVAVG 3265 Query: 249 AYFTFAISHEGHVYGFGLSNYHQLGTPGT 277 A A++ G VY +G +++ Q G T Sbjct: 3266 ALHCLAVTDSGQVYAWGDNDHGQQGNGTT 3294 Score = 69.3 bits (168), Expect = 6e-12 Identities = 48/119 (40%), Positives = 66/119 (55%), Gaps = 9/119 (7%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLSKSGQVY 89 TE G V + G GD G+LG G + K P L+ +D VV+ G ++ L+K GQVY Sbjct: 621 TENGQVWSWGDGDYGKLGRGGSD-GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 679 Query: 90 SFGCNDEGALGRDTS--VEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGS 145 S+G D LG T V +++ G LQ +KV+ V+AG +H ALT+D V WGS Sbjct: 680 SWGKGDNQRLGHGTEEHVRYPKLLEG---LQGKKVIDVAAGSTHCLALTEDSEVHSWGS 735 Score = 68.9 bits (167), Expect = 8e-12 Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 8/177 (4%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGMHTVCLSKSGQ 87 T G + T G+G+ G+LG G + + P LV+ + + V +G T+ ++++GQ Sbjct: 567 TAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ 625 Query: 88 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLWGSF 146 V+S+G D G LGR S +G + +LQ+ VV+V G + ALT DG+V+ WG Sbjct: 626 VWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG 684 Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 203 + G E ++ + +Q V+ VA+G+ H + LT D ++++ G +Q Q Sbjct: 685 DNQRLGHGTEEHVRYPKLLEGLQ-GKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740 >gi|222136641 NIMA-related kinase 9 [Homo sapiens] Length = 979 Score = 109 bits (273), Expect = 4e-24 Identities = 108/386 (27%), Positives = 172/386 (44%), Gaps = 73/386 (18%) Query: 71 QAEAGGMHTVCLSKSGQVYSF-----GCNDEGALGRDTSVEGSEMVPGKVE-LQEKVV-Q 123 Q AG H ++ ++Y++ G G LG + S P VE LQ K + Q Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGD--KASYRQPKHVEKLQGKAIRQ 430 Query: 124 VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGL--------LEPMKKSMVPVQVQLDVPVV 175 VS GD T +TD+G+++ +GS D G +G+ LEPM+ + L PV Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGS--DYYGCMGVDKVAGPEVLEPMQLNFF-----LSNPVE 483 Query: 176 KVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRG 235 +V+ G++H+V+LT + ++Y+ GCGE G+LG + +++ VPK +++ + Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLG-----LDSEEDYYTPQKVDVPKALIIVA-- 536 Query: 236 SRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLG----------------TPGTES 279 CG TF ++ G V GL+ +++LG P T S Sbjct: 537 ---------VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS 587 Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 + + L+ +K T + G+ HT +D G+ + G + G+LG+G + I Sbjct: 588 FTLAKQLSFYKIRT-----IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINL 642 Query: 340 LISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT-------GQDEDAWSPVE 390 L L V V+CG A T D +FAWG G N +L G D P Sbjct: 643 LGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRP 702 Query: 391 MMGKQLENRVVLSVSSGGQHTVLLVK 416 + G V +S G HT+L+V+ Sbjct: 703 IFGSL---HHVPDLSCRGWHTILIVE 725 Score = 68.2 bits (165), Expect = 1e-11 Identities = 69/265 (26%), Positives = 105/265 (39%), Gaps = 36/265 (13%) Query: 32 TEPGLVLTLGQGDVGQLGL----GENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 87 T+ G + G G +G+ G V+E + + V Q G H V L+++ + Sbjct: 442 TDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-LSNPVEQVSCGDNHVVVLTRNKE 500 Query: 88 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLWG- 144 VYS+GC + G LG D+ E P KV++ + +V V G T LT G+V G Sbjct: 501 VYSWGCGEYGRLGLDS--EEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGL 558 Query: 145 ----SFRDNNGVIGLLEPMKKSMVPVQVQLDV-------PVVKVASGNDHLVMLTADGDL 193 N + G++ VP + + +A G H + G L Sbjct: 559 NEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRL 618 Query: 194 YTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTF 253 T GC + GQLG N R G+ L P G + +R CG FT Sbjct: 619 LTFGCNKCGQLG-----VGNYKKRLGINLLGGP-------LGGKQVIRVS---CGDEFTI 663 Query: 254 AISHEGHVYGFGLSNYHQLGTPGTE 278 A + + H++ +G +L TE Sbjct: 664 AATDDNHIFAWGNGGNGRLAMTPTE 688 Score = 40.8 bits (94), Expect = 0.002 Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 15/147 (10%) Query: 283 PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL-----GRAEYGRLGLGEGAEEKSI 337 PQ L K+ + +G H V + E + Y+ G +G+LG G+ A + Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAV-VTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ- 416 Query: 338 PTLISRLP--AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 395 P + +L A+ V+CG VT +G+++A+G ++Y G D+ A P + Q Sbjct: 417 PKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFG--SDYYGCMGVDKVA-GPEVLEPMQ 473 Query: 396 LE---NRVVLSVSSGGQHTVLLVKDKE 419 L + V VS G H V+L ++KE Sbjct: 474 LNFFLSNPVEQVSCGDNHVVVLTRNKE 500 Score = 31.6 bits (70), Expect = 1.4 Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 4/77 (5%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGGMHTVCL 82 +H + E G +LT G GQLG+G N +R L+ P + V++ G T+ Sbjct: 607 THTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAA 665 Query: 83 SKSGQVYSFGCNDEGAL 99 + ++++G G L Sbjct: 666 TDDNHIFAWGNGGNGRL 682 >gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] Length = 522 Score = 104 bits (259), Expect = 2e-22 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%) Query: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106 LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191 Query: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166 ++ G E +V + G +HT ALT+ G VF +G + G +GL P Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247 Query: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224 Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307 Query: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277 VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367 Query: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337 + +P+ + F + G + + G + G R E Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420 Query: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394 P + L + S+ACG S V D +WG + +LG G + S K Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479 Query: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421 L+ V+ G H++++ +D+ ++ Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506 Score = 56.6 bits (135), Expect = 4e-08 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84 +H TE G V G+ +GQLGLG PA + + + + G ++ + Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271 Query: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120 G +YSFGC + G LG ++ + E+VP +V + Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170 V V+ G +HT L RVF WG G +G E K MVP V+L Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378 >gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] Length = 522 Score = 104 bits (259), Expect = 2e-22 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%) Query: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106 LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191 Query: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166 ++ G E +V + G +HT ALT+ G VF +G + G +GL P Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247 Query: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224 Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307 Query: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277 VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367 Query: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337 + +P+ + F + G + + G + G R E Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420 Query: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394 P + L + S+ACG S V D +WG + +LG G + S K Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479 Query: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421 L+ V+ G H++++ +D+ ++ Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506 Score = 56.6 bits (135), Expect = 4e-08 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84 +H TE G V G+ +GQLGLG PA + + + + G ++ + Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271 Query: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120 G +YSFGC + G LG ++ + E+VP +V + Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170 V V+ G +HT L RVF WG G +G E K MVP V+L Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378 >gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] Length = 4861 Score = 100 bits (248), Expect = 3e-21 Identities = 90/318 (28%), Positives = 148/318 (46%), Gaps = 31/318 (9%) Query: 35 GLVLTLGQGDVGQLGLGE----NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYS 90 G VL G+G G+LG G +V+ + +V + H++ L++SG+V+S Sbjct: 4046 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105 Query: 91 FGCNDEGALGRDTSVEGSEMVPGKVE-LQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRD 148 +G D G LG S + P ++E LQ E+VVQ+S G H+A +T DG++F +G+ Sbjct: 4106 WGDGDYGKLGHGNS--DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--G 4161 Query: 149 NNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL-YTLGCGEQGQLGR 206 + G +GL K + L+ + +VA G +H + ++ADG + + G G+ G+LG Sbjct: 4162 DYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG- 4220 Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266 N + +++ V + +K CG F+ A++ +GHVY FG Sbjct: 4221 ----LGNSTAKSSPQKIDVLCGIGIKK-----------VACGTQFSVALTKDGHVYTFGQ 4265 Query: 267 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326 L + PQ + V G HT+ + S G Y+ G G+L Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV--GAEHTLALASNGDVYAWGSNSEGQL 4323 Query: 327 GLGEGAEEKSIPTLISRL 344 GLG + PTL++ L Sbjct: 4324 GLGHTNHVRE-PTLVTGL 4340 Score = 95.1 bits (235), Expect = 1e-19 Identities = 93/348 (26%), Positives = 160/348 (45%), Gaps = 37/348 (10%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP----EDVVQAEAGGMHTVCLSKSGQVYS 90 G V G+G G+LGLG++ + L P + V ++ HT+ + G+V+S Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481 Query: 91 FGCNDEGALGRDTSVEGSEMVPGKVE--LQEKVVQ-VSAGDSHTAALTDDGRVFLWGSFR 147 +G D G LG S ++ P ++ LQ KVV VSAG H+AA+T+DG ++ WG Sbjct: 482 WGDGDYGKLGHGNS--STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWG--E 537 Query: 148 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG-DLYTLGCGEQGQLGR 206 + G +G + ++ +P V+ V +V+ G+ H + L+ DG +++ G G+ G+L Sbjct: 538 GDFGRLGHGDSNSRN-IPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKL-- 594 Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266 G R+ PK + +G + + G+ + A++ G VY +G Sbjct: 595 ---------GHGDTNRVYKPKVI----EALQG-MFIRKVCAGSQSSLALTSTGQVYAWGC 640 Query: 267 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326 LG +E+ + L +T+ V S G H + + + + Y+ G G+ Sbjct: 641 GAC--LGCGSSEATALRPKLIEELAATRI-VDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697 Query: 327 GLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVT---KDGRVFAW 369 G G + P +S L A+ ++ G S A T +D +V AW Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745 Score = 94.4 bits (233), Expect = 2e-19 Identities = 83/284 (29%), Positives = 132/284 (46%), Gaps = 25/284 (8%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKS 85 H TE G V + G GD G+LG G + +R+ + ++ E+VVQ G H+ ++ Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152 Query: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLW 143 G++++FG D G LG + ++ +P +V E ++ QV+ G +HT A++ DG + +W Sbjct: 4153 GKLFTFGNGDYGRLGLGNT--SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSM-VW 4209 Query: 144 GSFRDNNGVIGL-LEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 202 + G +GL K S + V + + KVA G V LT DG +YT G Q Sbjct: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG---QD 4266 Query: 203 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 262 +L +PE A R +L V +D GA T A++ G VY Sbjct: 4267 RLIGLPEGRARNHNRPQQIPVL-------------AGVIIEDVAVGAEHTLALASNGDVY 4313 Query: 263 GFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306 +G ++ QLG T P +T + K+ S G+ H+ Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQG--KNVRQISAGRCHS 4355 Score = 94.0 bits (232), Expect = 2e-19 Identities = 109/383 (28%), Positives = 163/383 (42%), Gaps = 42/383 (10%) Query: 41 GQGDVGQLG-LGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGAL 99 G G GQL G NVM PA Q G T + +G V + G G L Sbjct: 4003 GAGRHGQLAEAGRNVMV---PAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059 Query: 100 GRDTSVEGSEM-----VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG 154 G+ S + + + G V Q +V D H+ ALT+ G VF WG + G +G Sbjct: 4060 GQGNSDDLHVLTVISALQGFVVTQ--LVTSCGSDGHSMALTESGEVFSWGD--GDYGKLG 4115 Query: 155 LLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFA 212 ++ P Q++ VV+++ G H ++T+DG L+T G G+ G+LG Sbjct: 4116 HGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG-----LG 4169 Query: 213 NRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQ 271 N ++ ER+ + + G V CG T A+S +G V+ FG +Y + Sbjct: 4170 NTSNKKLPERVTALEGYQI------GQVA-----CGLNHTLAVSADGSMVWAFGDGDYGK 4218 Query: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEG 331 LG + + PQ + V G +V + +G Y+ G+ +GL EG Sbjct: 4219 LGLGNSTAKSSPQKIDVLCGIGIKKVAC--GTQFSVALTKDGHVYTFGQDRL--IGLPEG 4274 Query: 332 -AEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388 A + P I L V VA GA A+ +G V+AWG + QLG G P Sbjct: 4275 RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREP 4334 Query: 389 VEMMGKQLENRVVLSVSSGGQHT 411 + G Q +N V +S+G H+ Sbjct: 4335 TLVTGLQGKN--VRQISAGRCHS 4355 Score = 92.0 bits (227), Expect = 9e-19 Identities = 99/364 (27%), Positives = 153/364 (42%), Gaps = 37/364 (10%) Query: 59 KPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118 +P L D EAG T +S G V + G G LG S S + E Sbjct: 395 QPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPH 454 Query: 119 EKVVQVSAG---DSHTAALTDDGRVFLWGSF---RDNNGVIGLLEPMKKSMVPVQVQLDV 172 + +VS+ D HT A T +G VF WG + +G + K P+Q ++ Sbjct: 455 RSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKV-- 512 Query: 173 PVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLK 232 VV V++G H +T DG+LYT G G+ G+LG N +P ++K Sbjct: 513 -VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRN-----------IP--TLVK 558 Query: 233 SRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291 + G V CG+ T A+S +G V+ FG + +LG T + P+ + + + Sbjct: 559 DISNVGEVS-----CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613 Query: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSS 349 V G ++ + S G+ Y+ G LG G P LI L A + Sbjct: 614 MFIRKV--CAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVD 669 Query: 350 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE-DAWSPVEMMGKQLENRVVLSVSSGG 408 V+ G S A++ D V+AWG + Q G G P ++ G L+ + +S+G Sbjct: 670 VSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG--LDGIAIQQISAGT 727 Query: 409 QHTV 412 H++ Sbjct: 728 SHSL 731 Score = 86.3 bits (212), Expect = 5e-17 Identities = 78/259 (30%), Positives = 115/259 (44%), Gaps = 27/259 (10%) Query: 20 SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGG 76 S K H T G V + G GD G+LG G N +K P L+ P + VV AG Sbjct: 462 SSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHG-NSSTQKYPKLIQGPLQGKVVVCVSAGY 520 Query: 77 MHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTD 136 H+ +++ G++Y++G D G LG S S +P V+ V +VS G SHT AL+ Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGHGDS--NSRNIPTLVKDISNVGEVSCGSSHTIALSK 578 Query: 137 DGRVFLWGSFRDNNGVIGLLEPMK--KSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 194 DGR +W +NG +G + + K V ++ + + KV +G+ + LT+ G +Y Sbjct: 579 DGRT-VWSFGGGDNGKLGHGDTNRVYKPKV-IEALQGMFIRKVCAGSQSSLALTSTGQVY 636 Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254 GCG A G L PK + R D G A Sbjct: 637 AWGCG------------ACLGCGSSEATALRPKLI-----EELAATRIVDVSIGDSHCLA 679 Query: 255 ISHEGHVYGFGLSNYHQLG 273 +SH+ VY +G ++ Q G Sbjct: 680 LSHDNEVYAWGNNSMGQCG 698 Score = 84.0 bits (206), Expect = 2e-16 Identities = 79/288 (27%), Positives = 127/288 (44%), Gaps = 39/288 (13%) Query: 140 VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCG 199 V+LWG+ R L E + MVP +V G + ++ A+G + G G Sbjct: 3999 VYLWGAGRHGQ----LAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEG 4054 Query: 200 EQGQLGRVPELFANRGGRQGLERLLVPKCV-------MLKSRGSRGHVRFQDAFCGAYFT 252 G+LG+ G L L V + ++ S GS GH + Sbjct: 4055 SYGRLGQ--------GNSDDLHVLTVISALQGFVVTQLVTSCGSDGH------------S 4094 Query: 253 FAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 312 A++ G V+ +G +Y +LG ++ P+ + + + + V S G H+ + S+ Sbjct: 4095 MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG--EEVVQMSCGFKHSAVVTSD 4152 Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDG-RVFAW 369 GK ++ G +YGRLGLG K +P ++ L + VACG + AV+ DG V+A+ Sbjct: 4153 GKLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211 Query: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 G G +LG G SP ++ L + V+ G Q +V L KD Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKI--DVLCGIGIKKVACGTQFSVALTKD 4257 Score = 83.2 bits (204), Expect = 4e-16 Identities = 67/208 (32%), Positives = 100/208 (48%), Gaps = 15/208 (7%) Query: 8 KRRSPPADAIPKSKKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALV 63 +RR +A+ + V++S H + T G + T G GD G+LGLG N +K P V Sbjct: 4122 QRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLG-NTSNKKLPERV 4180 Query: 64 SIPE--DVVQAEAGGMHTVCLSKSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 + E + Q G HT+ +S G V++FG D G LG S S V Sbjct: 4181 TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG 4240 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKS---MVPVQVQLDVPVVKV 177 + +V+ G + ALT DG V+ +G R +IGL E ++ + V V + V Sbjct: 4241 IKKVACGTQFSVALTKDGHVYTFGQDR----LIGLPEGRARNHNRPQQIPVLAGVIIEDV 4296 Query: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLG 205 A G +H + L ++GD+Y G +GQLG Sbjct: 4297 AVGAEHTLALASNGDVYAWGSNSEGQLG 4324 Score = 79.0 bits (193), Expect = 8e-15 Identities = 88/354 (24%), Positives = 154/354 (43%), Gaps = 52/354 (14%) Query: 82 LSKSGQVYSFGCNDEGAL--GRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGR 139 +S++ +VY +G N L G + ++ P + Q + AG T ++ DG Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT----IEAGQYCTFVISTDGS 423 Query: 140 VFLWGSFRDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGND-HLVMLTADGDLYT 195 V G + + G +GL + +S + + + V + G+D H + T +G++++ Sbjct: 424 VRACG--KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481 Query: 196 LGCGEQGQLG-------RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 248 G G+ G+LG + P+L +G QG K V+ S G R Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLI--QGPLQG-------KVVVCVSAGYR----------- 521 Query: 249 AYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308 + A++ +G +Y +G ++ +LG + S IP + N + S G HT+ Sbjct: 522 --HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGE----VSCGSSHTIA 575 Query: 309 MDSEGKA-YSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 365 + +G+ +S G + G+LG G+ P +I L + V G+ A+T G+ Sbjct: 576 LSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQ 634 Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419 V+AWG G LG G E +++ + R+V VS G H + L D E Sbjct: 635 VYAWGCGA--CLGCGSSEATALRPKLIEELAATRIV-DVSIGDSHCLALSHDNE 685 Score = 78.6 bits (192), Expect = 1e-14 Identities = 57/185 (30%), Positives = 89/185 (48%), Gaps = 12/185 (6%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSG 86 H + TE G + T G+GD G+LG G++ R P LV +V + G HT+ LSK G Sbjct: 522 HSAAVTEDGELYTWGEGDFGRLGHGDS-NSRNIPTLVKDISNVGEVSCGSSHTIALSKDG 580 Query: 87 Q-VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLW 143 + V+SFG D G LG + P +E + + +V AG + ALT G+V+ W Sbjct: 581 RTVWSFGGGDNGKLGHGDT--NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638 Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201 G +G ++ P ++ +V V+ G+ H + L+ D ++Y G Sbjct: 639 GC----GACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSM 694 Query: 202 GQLGR 206 GQ G+ Sbjct: 695 GQCGQ 699 Score = 47.0 bits (110), Expect = 3e-05 Identities = 39/110 (35%), Positives = 54/110 (49%), Gaps = 11/110 (10%) Query: 32 TEPGLVLTLGQGDVGQLGLGEN-VMERKKPALVSIPEDVV--QAEAGGMHTVCLSKSGQV 88 T+ G V T GQ + +GL E +P + + V+ G HT+ L+ +G V Sbjct: 4255 TKDGHVYTFGQDRL--IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDV 4312 Query: 89 YSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVV-QVSAGDSHTAALT 135 Y++G N EG LG V +V G LQ K V Q+SAG H+AA T Sbjct: 4313 YAWGSNSEGQLGLGHTNHVREPTLVTG---LQGKNVRQISAGRCHSAAWT 4359 >gi|61563742 hect domain and RLD 6 [Homo sapiens] Length = 1022 Score = 97.8 bits (242), Expect = 2e-20 Identities = 92/334 (27%), Positives = 161/334 (48%), Gaps = 34/334 (10%) Query: 49 GLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGS 108 G ++R++ A S +++QA +G H++ L + +V S G N G LGR + G Sbjct: 6 GADSRELQRRRTA-GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64 Query: 109 EMVPGKVELQEKVVQ--VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166 +P ++ E ++ VS G H+ A+ GRVF WG+ + G +G+ E + S P Sbjct: 65 --LPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPK 120 Query: 167 QVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLL 224 ++ D+ +++V+ G+ H + L+ D +++ G GQLG E F ++ Q Sbjct: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE-FPSQASPQ------ 173 Query: 225 VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE---SCF 281 + R G Q A GA+ +FA+S G +G+G ++ QL G Sbjct: 174 -------RVRSLEGIPLAQVAAGGAH-SFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225 Query: 282 IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLI 341 P ++ + KN ++ S G HT + +GK ++ G G+LG E++ P L+ Sbjct: 226 KPLSVGALKNLGVVYI--SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG-PQLV 282 Query: 342 SRLPA-VSSVACGA--SVGYAVTKDGRVFAWGMG 372 R+ VS + CG+ ++ Y T G+V ++G G Sbjct: 283 ERIDGLVSQIDCGSYHTLAYVHT-TGQVVSFGHG 315 Score = 87.4 bits (215), Expect = 2e-17 Identities = 77/238 (32%), Positives = 107/238 (44%), Gaps = 25/238 (10%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLSKSGQVYSFG 92 G V G G GQLG+GE P + D ++Q G H++ LSK QV+S+G Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153 Query: 93 CNDEGALGRDTSVEGSEMVPGKVELQEKV--VQVSAGDSHTAALTDDGRVFLWGSFRDNN 150 N G LG S+ P +V E + QV+AG +H+ AL+ G F WGS Sbjct: 154 KNSHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212 Query: 151 GVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208 + +S P+ V ++ VV ++ G+ H +LT DG ++T G GQLG P Sbjct: 213 LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272 Query: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH-EGHVYGFG 265 + G Q +ER+ G V D CG+Y T A H G V FG Sbjct: 273 T--PEKRGPQLVERI-------------DGLVSQID--CGSYHTLAYVHTTGQVVSFG 313 Score = 80.5 bits (197), Expect = 3e-15 Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 30/252 (11%) Query: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGR----QGLERLLVPKCV 229 +++ ASG H ++L + + + G +GQLGR A RG Q LE L+V Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG---AQRGELPEPIQALETLIVDL-- 79 Query: 230 MLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG-TESCFIPQNLTS 288 CG + A+ H+G V+ +G + QLG E F P+ + + Sbjct: 80 ---------------VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124 Query: 289 FKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV- 347 N K + S G +H++ + + + +S G+ +G+LGLG+ ++ P + L + Sbjct: 125 L-NDIKI-IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182 Query: 348 -SSVACGASVGYAVTKDGRVFAWGMGTNYQLG-TGQDEDAWSPVEMMGKQLENRVVLSVS 405 + VA G + +A++ G F WG + QL +G++ S + L+N V+ +S Sbjct: 183 LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYIS 242 Query: 406 SGGQHTVLLVKD 417 G HT +L +D Sbjct: 243 CGDAHTAVLTQD 254 Score = 72.8 bits (177), Expect = 6e-13 Identities = 77/307 (25%), Positives = 135/307 (43%), Gaps = 38/307 (12%) Query: 120 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMV-PVQVQLDVPVVKVA 178 +++Q ++G+ H+ L + RV G ++ G +G + + P+Q + V V+ Sbjct: 24 ELLQAASGERHSLLLLTNHRVLSCGD--NSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81 Query: 179 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 238 G +H + + G ++ G G +GQLG + E E PK +M + Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLG-IGEF---------KEISFTPKKIM-----TLN 126 Query: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSW 296 ++ CG Y + A+S + V+ +G +++ QLG G E S PQ + S + + Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIPLAQ 185 Query: 297 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG--EGAEEKSIPTLISRLP--AVSSVAC 352 V G H+ + G ++ G G+L L + + P + L V ++C Sbjct: 186 VAAGGA--HSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243 Query: 353 GASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV-EMMGKQLENRV---VLSVSSGG 408 G + +T+DG+VF +G + QLG +SP E G QL R+ V + G Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLG-------YSPTPEKRGPQLVERIDGLVSQIDCGS 296 Query: 409 QHTVLLV 415 HT+ V Sbjct: 297 YHTLAYV 303 Score = 65.5 bits (158), Expect = 9e-11 Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 6/185 (3%) Query: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291 ++ GS G Q A G + + V G ++ QLG G + +P+ + + + Sbjct: 16 RTAGSPGAELLQAA-SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74 Query: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--S 349 V S G+ H++ + +G+ ++ G G+LG+GE E P I L + Sbjct: 75 LIVDLV--SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQ 132 Query: 350 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQ 409 V+CG A++KD +VF+WG ++ QLG G++ + + + + + LE + V++GG Sbjct: 133 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV-RSLEGIPLAQVAAGGA 191 Query: 410 HTVLL 414 H+ L Sbjct: 192 HSFAL 196 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 6/123 (4%) Query: 300 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 357 + G+ H++ + + + S G G+LG GA+ +P I L V V+CG Sbjct: 29 ASGERHSLLLLTNHRVLSCGDNSRGQLGR-RGAQRGELPEPIQALETLIVDLVSCGKEHS 87 Query: 358 YAVTKDGRVFAWGMGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416 AV GRVFAWG G+ QLG G+ E +++P ++M L + ++ VS G H++ L K Sbjct: 88 LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM--TLNDIKIIQVSCGHYHSLALSK 145 Query: 417 DKE 419 D + Sbjct: 146 DSQ 148 Score = 36.2 bits (82), Expect = 0.057 Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVC-LS 83 +H + T+ G V T G GQLG E++ P LV + +V Q + G HT+ + Sbjct: 246 AHTAVLTQDGKVFTFGDNRSGQLGYSP-TPEKRGPQLVERIDGLVSQIDCGSYHTLAYVH 304 Query: 84 KSGQVYSFG 92 +GQV SFG Sbjct: 305 TTGQVVSFG 313 >gi|6912330 deafness locus associated putative guanine nucleotide exchange factor [Homo sapiens] Length = 458 Score = 96.7 bits (239), Expect = 4e-20 Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%) Query: 41 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98 G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80 Query: 99 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158 LG + + P K + QV+ G T LT++G+V GS ++ G +G+ Sbjct: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138 Query: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211 ++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF Sbjct: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198 Query: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269 A R GLE CV+ G+ + +++ G VY +G + + Sbjct: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241 Query: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323 QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y Sbjct: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294 Query: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366 G+LG L S+P+ L + V+CG+ A+ G Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353 Query: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414 ++WG + G G + + W+P + + L + L V G H++ L Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399 Score = 68.6 bits (166), Expect = 1e-11 Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85 H + T+ G + G GQLGLG + P + Q G T+ L+++ Sbjct: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119 Query: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144 GQV S G N G LG +VP +EL +EKVV ++AG H A T G VF WG Sbjct: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178 Query: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198 + + G G P+ K V + + V +G+DH LT G++Y G Sbjct: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238 Query: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258 + GQL AN + + + C + + + G A + Sbjct: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283 Query: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304 G ++ +G ++Y QLG + F+ P ++ S + S G Sbjct: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343 Query: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 H + + G YS G E+G G G A + P + L + S + G G+++ Sbjct: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397 Score = 47.4 bits (111), Expect = 2e-05 Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%) Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 ++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75 Query: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379 + G+LGLG + S + VACG +T++G+V + G + QLG Sbjct: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135 Query: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 V +L V+ +++G +H V Sbjct: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166 Score = 34.7 bits (78), Expect = 0.17 Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68 +H TE G + T G+ D GQLG E R ++ S P Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334 Query: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128 + G H + + G YS+G N+ G G T P + L + V G Sbjct: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393 Query: 129 SHTAAL 134 H+ AL Sbjct: 394 GHSLAL 399 Score = 32.3 bits (72), Expect = 0.83 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%) Query: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414 S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++ Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64 >gi|57242759 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [Homo sapiens] Length = 531 Score = 89.4 bits (220), Expect = 6e-18 Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%) Query: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169 P ++ K S +TD+ VF++G N G + ++VP +++ Sbjct: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71 Query: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227 + + SG H+++ T DG +Y G QLG N QG+ + V Sbjct: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123 Query: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287 +++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T Sbjct: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175 Query: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347 + + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V Sbjct: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233 Query: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405 + + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV + Sbjct: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291 Query: 406 SGGQHT 411 HT Sbjct: 292 CHSAHT 297 Score = 70.9 bits (172), Expect = 2e-12 Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 +SP+ IA R S+ + V T+ V G LG G+N Sbjct: 13 LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66 Query: 61 ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118 L + +++ + G H + ++ G VY++G N LG T+ +G V L Sbjct: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126 Query: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174 ++VV+V+ G H+ AL DG VF WG +N G +G + P +V L + V Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183 Query: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234 V +A G + + +G++Y G GQLG N G + L P V Sbjct: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227 Query: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286 + V CG T A++ EG +Y +G + Y QLGT + P ++ Sbjct: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279 Score = 53.5 bits (127), Expect = 3e-07 Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93 G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259 Query: 94 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150 N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R + Sbjct: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317 Query: 151 GVI 153 ++ Sbjct: 318 VIL 320 >gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo sapiens] Length = 464 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 Query: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 Query: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 Query: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 G V A+S +G ++G+G S Y QL + + Sbjct: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 F K GG V ++ EG + G YG LG G E ++P Sbjct: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 Query: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 Query: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416 V M G+ ++ V+ G H V L K Sbjct: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 >gi|4557445 regulator of chromosome condensation and BTB domain containing protein 2 [Homo sapiens] Length = 551 Score = 83.2 bits (204), Expect = 4e-16 Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%) Query: 37 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94 + LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N Sbjct: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126 Query: 95 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151 LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G Sbjct: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182 Query: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208 +G + + +P +V + VV +A G + + G++Y G GQLG Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238 Query: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268 N G + C + +G +R Q CG T ++ EG VY +G ++ Sbjct: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285 Query: 269 YHQLGTPGTESCFIPQNLTSFKN 291 Y QLGT + P +T K+ Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKD 308 Score = 78.2 bits (191), Expect = 1e-14 Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%) Query: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242 H+V+ T +G+++T G QLG N G LVP C + + ++ + Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155 Query: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302 + CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G Sbjct: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213 Query: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360 Q + + G+ Y G G+LGLG + + P ++ L V VACG + + Sbjct: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411 T +G+V+AWG + QLGTG + P + + ++R++ + HT Sbjct: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%) Query: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329 LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G Sbjct: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136 Query: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388 G I T +S + VACG+ +T DG VFAWG + Q+G+G + P Sbjct: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195 Query: 389 VEMMGKQLENRVVLSVSSG 407 + G L+N+VV++++ G Sbjct: 196 RRVTG-CLQNKVVVTIACG 213 Score = 58.5 bits (140), Expect = 1e-08 Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%) Query: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90 + G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+ Sbjct: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280 Query: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148 +G N G LG S P VE ++++++++A S HT AA T G V++WG R Sbjct: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339 Query: 149 NNGVI 153 + ++ Sbjct: 340 QSVIL 344 >gi|30039692 NIMA-related kinase 8 [Homo sapiens] Length = 692 Score = 81.3 bits (199), Expect = 2e-15 Identities = 89/379 (23%), Positives = 156/379 (41%), Gaps = 58/379 (15%) Query: 68 DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK------- 120 +VVQ AG +++SG++ + GA G ++PG VE + Sbjct: 333 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-------GGGSLLPGAVEQPQPQFISRFL 385 Query: 121 -------VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEPMKKSMVPVQVQLD 171 + V+ GD TA LTD G + +GS +NG +G L + + + V+ L Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGS--GSNGCLGHGSLTDISQPTI-VEALLG 442 Query: 172 VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVML 231 +V+VA G H++ L+ + +L+ G G+ G+LG R +++ +P Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLG-----LGTRESHSCPQQVPMPP---- 493 Query: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG------------TES 279 G Q CG + ++ G G + +++LG E Sbjct: 494 ---GQEA----QRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEE 546 Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 L S + + G H+ + + G Y+ G ++G+LG ++ P Sbjct: 547 ALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PC 605 Query: 340 LISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 397 + L + + VACG + A+ + V++WG G +LG +DEDA P + + Sbjct: 606 KVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETH 664 Query: 398 NRVVLSVSSGGQHTVLLVK 416 V SVS +T+L V+ Sbjct: 665 PYTVTSVSCCHGNTLLAVR 683 Score = 77.0 bits (188), Expect = 3e-14 Identities = 71/259 (27%), Positives = 110/259 (42%), Gaps = 36/259 (13%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVCLSKSGQVY 89 T+ G+++T G G G LG G ++ + +P +V + ++VQ G H + LS +++ Sbjct: 407 TDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELF 465 Query: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTDDGRVFLWGSFR 147 ++G D G LG T S P +V + ++ +V G + LT G+ GS R Sbjct: 466 AWGRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNR 523 Query: 148 DNNGVIGLL----EPMKKSMVPVQVQLDV---------PVVKVASGNDHLVMLTADGDLY 194 N + L EP+ V + + P++ + G H +TA GD Y Sbjct: 524 FNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCY 583 Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254 T G + GQLG RG R K +G G ++ CG FT A Sbjct: 584 TFGSNQHGQLG----TNTRRGSR-----------APCKVQGLEG-IKMAMVACGDAFTVA 627 Query: 255 ISHEGHVYGFGLSNYHQLG 273 I E VY +G +LG Sbjct: 628 IGAESEVYSWGKGARGRLG 646 Score = 66.6 bits (161), Expect = 4e-11 Identities = 81/324 (25%), Positives = 130/324 (40%), Gaps = 41/324 (12%) Query: 117 LQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP------VQVQL 170 L +VVQV+AG + A +T GR+ LW + G LL + P ++ Q Sbjct: 330 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS 389 Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230 V + VA G+ LT G + T G G G LG G + + + + ++ Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLG--------HGSLTDISQPTIVEALL 441 Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290 G+ Q A CGA A+S E ++ +G + +LG ES PQ + Sbjct: 442 -------GYEMVQVA-CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPP 493 Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-----------EGAEEKSIPT 339 V G ++ + G+A + G + +LGL + EE T Sbjct: 494 GQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551 Query: 340 LISRLP----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 395 L+ P + S+ G + AVT G + +G + QLGT + +P ++ G Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-- 609 Query: 396 LENRVVLSVSSGGQHTVLLVKDKE 419 LE + V+ G TV + + E Sbjct: 610 LEGIKMAMVACGDAFTVAIGAESE 633 Score = 34.7 bits (78), Expect = 0.17 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 7/112 (6%) Query: 11 SPPADAIPK-SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV 69 S P D P S + +H + T G T G GQLG R P V E + Sbjct: 555 SAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PCKVQGLEGI 613 Query: 70 VQA--EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 119 A G TV + +VYS+G G LGR G +P V+L E Sbjct: 614 KMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAG---LPRPVQLDE 662 >gi|110825982 hect domain and RLD 5 [Homo sapiens] Length = 1024 Score = 80.1 bits (196), Expect = 3e-15 Identities = 78/313 (24%), Positives = 128/313 (40%), Gaps = 41/313 (13%) Query: 120 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVAS 179 K+ V G H L+ DG+ F + ++ K + + + ++++ Sbjct: 98 KIHSVDQGAEHMLILSSDGKPFEYDNYS------------MKHLRFESILQEKKIIQITC 145 Query: 180 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH 239 G+ H + L+ G+L+ G GQLG V F + Q +E L Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL--------------AG 190 Query: 240 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF 299 V G + A+S G++Y +G + QLG TES P + N +V Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC 250 Query: 300 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 357 G H+ + +G ++ G ++G+LG E P L++ L V+ +ACG Sbjct: 251 GGS--HSALLTQDGLLFTFGAGKHGQLGHNSTQNELR-PCLVAELVGYRVTQIACGRWHT 307 Query: 358 YAVTKD-GRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSS--------GG 408 A D G+VF++G G + QLG G D P+ + E + S +S GG Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367 Query: 409 QHTVLLVKDKEQS 421 ++LL KE S Sbjct: 368 NQSILLWIKKENS 380 Score = 73.2 bits (178), Expect = 4e-13 Identities = 73/326 (22%), Positives = 144/326 (44%), Gaps = 42/326 (12%) Query: 21 KKVKVSHRSHSTEPGLVLTLGQGDVG----QLGLGENVMERKKPALVSIPEDVVQAEAGG 76 ++V+V+ R PG + L +G G QL G K + + + G Sbjct: 48 RRVEVT-RQLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGA 106 Query: 77 MHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTD 136 H + LS G+ + + L ++ ++ ++K++Q++ GD H+ AL+ Sbjct: 107 EHMLILSSDGKPFEYDNYSMKHLRFESILQ-----------EKKIIQITCGDYHSLALSK 155 Query: 137 DGRVFLWGSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLY 194 G +F WG ++ +G +G+ + P V+ VP+ ++++G H + L+ G++Y Sbjct: 156 GGELFAWG--QNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIY 213 Query: 195 TLGCGEQGQLG-RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTF 253 + G E GQLG E + +GL+ + + + CG + Sbjct: 214 SWGKNECGQLGLGHTESKDDPSLIEGLD-----------------NQKVEFVACGGSHSA 256 Query: 254 AISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE- 312 ++ +G ++ FG + QLG T++ P + + + + G+ HT+ S+ Sbjct: 257 LLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGRWHTLAYVSDL 314 Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIP 338 GK +S G + G+LG G G ++ +P Sbjct: 315 GKVFSFGSGKDGQLGNG-GTRDQLMP 339 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 8/110 (7%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVC-L 82 SH + T+ GL+ T G G GQLG + +P LV+ + V Q G HT+ + Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311 Query: 83 SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132 S G+V+SFG +G LG + + +P KV E++ +SHT+ Sbjct: 312 SDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKL----ESHTS 357 >gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo sapiens] Length = 267 Score = 69.7 bits (169), Expect = 5e-12 Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%) Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230 D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80 Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290 G V A+S +G ++G+G S Y QL + + F Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136 Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 345 K GG V ++ EG + G YG LG G E ++P +I Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192 Query: 346 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 398 VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++ Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251 Query: 399 RVVLSVSSGGQHTVLLVK 416 V+ G H V L K Sbjct: 252 -----VACGVDHMVTLAK 264 Score = 55.5 bits (132), Expect = 9e-08 Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%) Query: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146 G N G GR VE S V + +VVQV+ G H+ LTD G V+ G Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60 Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206 D +G V V++VA+ D + ++ADG L+ G E QL Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120 Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266 V + ++ VP+C+ G + + A CG ++ EGHV+ +G Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164 Query: 267 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318 Y LG P +P+ LT F N G + ++G+ + Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221 Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 353 G+ G LG+G E++ P ++ VACG Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255 Score = 42.0 bits (97), Expect = 0.001 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%) Query: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127 VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+ Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94 Query: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177 A++ DG +F WG+ E ++ + V Q++VP V + Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144 Query: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237 A G +L +G ++ G G LG+ P L + ++ P L Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194 Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287 ++ CG A++++G ++ +G + LG E + P +T Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244 >gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo sapiens] Length = 267 Score = 69.7 bits (169), Expect = 5e-12 Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%) Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230 D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80 Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290 G V A+S +G ++G+G S Y QL + + F Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136 Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 345 K GG V ++ EG + G YG LG G E ++P +I Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192 Query: 346 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 398 VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++ Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251 Query: 399 RVVLSVSSGGQHTVLLVK 416 V+ G H V L K Sbjct: 252 -----VACGVDHMVTLAK 264 Score = 55.5 bits (132), Expect = 9e-08 Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%) Query: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146 G N G GR VE S V + +VVQV+ G H+ LTD G V+ G Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60 Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206 D +G V V++VA+ D + ++ADG L+ G E QL Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120 Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266 V + ++ VP+C+ G + + A CG ++ EGHV+ +G Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164 Query: 267 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318 Y LG P +P+ LT F N G + ++G+ + Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221 Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 353 G+ G LG+G E++ P ++ VACG Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255 Score = 42.0 bits (97), Expect = 0.001 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%) Query: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127 VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+ Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94 Query: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177 A++ DG +F WG+ E ++ + V Q++VP V + Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144 Query: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237 A G +L +G ++ G G LG+ P L + ++ P L Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194 Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287 ++ CG A++++G ++ +G + LG E + P +T Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244 >gi|63054860 RCC1 domain containing 1 [Homo sapiens] Length = 376 Score = 68.6 bits (166), Expect = 1e-11 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92 G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235 Query: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149 N+ G L R+ + +G + EL E QV R Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274 Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205 G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333 Score = 50.8 bits (120), Expect = 2e-06 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%) Query: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146 G E GR V P + + +VSA S+TA +T GR+ L GS Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71 Query: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200 +D GLL ++ P + L V + A + L V+ A+G+ G + Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130 Query: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260 G+L +P A R R L P+ +R + GA + G Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178 Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236 Query: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343 E G+L L GE GAE+ + P L+ Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295 Query: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397 LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+ Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355 Query: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421 V +V+ G +T + +K +S Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376 >gi|63054858 RCC1 domain containing 1 [Homo sapiens] Length = 376 Score = 68.6 bits (166), Expect = 1e-11 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92 G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235 Query: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149 N+ G L R+ + +G + EL E QV R Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274 Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205 G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333 Score = 50.8 bits (120), Expect = 2e-06 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%) Query: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146 G E GR V P + + +VSA S+TA +T GR+ L GS Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71 Query: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200 +D GLL ++ P + L V + A + L V+ A+G+ G + Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130 Query: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260 G+L +P A R R L P+ +R + GA + G Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178 Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236 Query: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343 E G+L L GE GAE+ + P L+ Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295 Query: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397 LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+ Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355 Query: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421 V +V+ G +T + +K +S Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376 >gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo sapiens] Length = 1102 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 5/155 (3%) Query: 259 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318 G V+ +G ++ +LG G+E C IPQN+ + G + + G ++ Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 782 Query: 319 GRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQL 377 G+ +Y RLG + + + R + VA GA AV G+V+AWG + Q Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842 Query: 378 GTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 G G P+ + G LE + ++ V+ G H+V Sbjct: 843 GNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 875 Score = 58.9 bits (141), Expect = 8e-09 Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 2/155 (1%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 93 GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784 Query: 94 NDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVI 153 D LG + V ++ + +K+V V+ G H A+ D G+V+ WG Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844 Query: 154 GLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188 G +K M+ VQ ++ VA G+ H V T Sbjct: 845 GTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 878 Score = 54.7 bits (130), Expect = 2e-07 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90 T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+ Sbjct: 774 TKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 833 Query: 91 FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135 +G ND G G T+V M+ +E Q K++ V+ G SH+ A T Sbjct: 834 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 878 Score = 53.9 bits (128), Expect = 3e-07 Identities = 39/110 (35%), Positives = 55/110 (50%), Gaps = 6/110 (5%) Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 370 G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG Sbjct: 725 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 783 Query: 371 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 G ++LG D + G L + ++ V+ G QH L V D Q Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 830 Score = 45.1 bits (105), Expect = 1e-04 Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 24/186 (12%) Query: 181 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237 +D+ +LT G +++ G G+ G+LGR GG +G +P+ + + + Sbjct: 712 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 758 Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 297 G + + CGA F A++ G V+ +G +Y +LG Q + + V Sbjct: 759 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHV 815 Query: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355 G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S Sbjct: 816 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 872 Query: 356 VGYAVT 361 A T Sbjct: 873 HSVAWT 878 >gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo sapiens] Length = 596 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%) Query: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316 +E V+ +G ++ +LG G+E C IPQN+ + G + + G + Sbjct: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78 Query: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374 + G+ +Y RLG + P ++ L + VA GA AV G+V+AWG + Sbjct: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137 Query: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 Q G G P + G LE + ++ V+ G H+V Sbjct: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173 Score = 57.4 bits (137), Expect = 2e-08 Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%) Query: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369 E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W Sbjct: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80 Query: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 G G ++LG D P + G L + ++ V+ G QH L V D Q Sbjct: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128 Score = 54.3 bits (129), Expect = 2e-07 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%) Query: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94 LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G Sbjct: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83 Query: 95 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152 D LG D V ++V G +K+V V+ G H A+ D G+V+ WG Sbjct: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141 Query: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188 G +K + VQ ++ VA G+ H V T Sbjct: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90 T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+ Sbjct: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131 Query: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135 +G ND G G T+ + + +K++ V+ G SH+ A T Sbjct: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176 Score = 50.4 bits (119), Expect = 3e-06 Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%) Query: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233 ++ SG + LV DGD LG RGG +G +P+ + + Sbjct: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52 Query: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293 +G + + CGA F A++ G V+ +G +Y +LG PQ + + Sbjct: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109 Query: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351 V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA Sbjct: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166 Query: 352 CGASVGYAVT 361 CG+S A T Sbjct: 167 CGSSHSVAWT 176 >gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo sapiens] Length = 1052 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 7/156 (4%) Query: 259 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318 G V+ +G ++ +LG G+E C IPQN+ + G + + G ++ Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 732 Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQ 376 G+ +Y RLG + P ++ L + VA GA AV G+V+AWG + Q Sbjct: 733 GKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791 Query: 377 LGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 G G P+ + G LE + ++ V+ G H+V Sbjct: 792 QGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 825 Score = 58.9 bits (141), Expect = 8e-09 Identities = 49/157 (31%), Positives = 73/157 (46%), Gaps = 6/157 (3%) Query: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 93 GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734 Query: 94 NDEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151 D LG D V ++V G +K+V V+ G H A+ D G+V+ WG Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792 Query: 152 VIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188 G +K M+ VQ ++ VA G+ H V T Sbjct: 793 GNGTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 828 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/110 (36%), Positives = 56/110 (50%), Gaps = 6/110 (5%) Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 370 G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG Sbjct: 675 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 733 Query: 371 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 G ++LG D P + G L + ++ V+ G QH L V D Q Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 780 Score = 55.1 bits (131), Expect = 1e-07 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%) Query: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90 T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+ Sbjct: 724 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 783 Query: 91 FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135 +G ND G G T+V M+ +E Q K++ V+ G SH+ A T Sbjct: 784 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 828 Score = 48.9 bits (115), Expect = 9e-06 Identities = 51/186 (27%), Positives = 84/186 (45%), Gaps = 24/186 (12%) Query: 181 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237 +D+ +LT G +++ G G+ G+LGR GG +G +P+ + + + Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 708 Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 297 G + + CGA F A++ G V+ +G +Y +LG PQ + + V Sbjct: 709 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHV 765 Query: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355 G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S Sbjct: 766 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 822 Query: 356 VGYAVT 361 A T Sbjct: 823 HSVAWT 828 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.134 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,054,567 Number of Sequences: 37866 Number of extensions: 784303 Number of successful extensions: 2631 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 63 Number of HSP's successfully gapped in prelim test: 15 Number of HSP's that attempted gapping in prelim test: 1678 Number of HSP's gapped (non-prelim): 273 length of query: 421 length of database: 18,247,518 effective HSP length: 105 effective length of query: 316 effective length of database: 14,271,588 effective search space: 4509821808 effective search space used: 4509821808 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.