Guide to the Human Genome
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Search of human proteins with 114796648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114796648 regulator of chromosome condensation 1 [Homo
sapiens]
         (421 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...   850   0.0  
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]    850   0.0  
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]    850   0.0  
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]    850   0.0  
gi|114796646 regulator of chromosome condensation 1 isoform b [H...   840   0.0  
gi|114796644 regulator of chromosome condensation 1 isoform a [H...   834   0.0  
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            142   6e-34
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            142   6e-34
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...   136   4e-32
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...   136   4e-32
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       132   6e-31
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     124   2e-28
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                     109   4e-24
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]    104   2e-22
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]     104   2e-22
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]   100   3e-21
gi|61563742 hect domain and RLD 6 [Homo sapiens]                       98   2e-20
gi|6912330 deafness locus associated putative guanine nucleotide...    97   4e-20
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...    89   6e-18
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...    87   2e-17
gi|4557445 regulator of chromosome condensation and BTB domain c...    83   4e-16
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       81   2e-15
gi|110825982 hect domain and RLD 5 [Homo sapiens]                      80   3e-15
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo...    70   5e-12
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo...    70   5e-12
gi|63054860 RCC1 domain containing 1 [Homo sapiens]                    69   1e-11
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                    69   1e-11
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    60   3e-09
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    60   4e-09
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...    60   4e-09

>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score =  850 bits (2197), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
           MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60

Query: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120
           ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
Sbjct: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180
           VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180

Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
           NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240

Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
           RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300

Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
           GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360

Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
           TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420

Query: 421 S 421
           S
Sbjct: 421 S 421


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  850 bits (2197), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
           MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60

Query: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120
           ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
Sbjct: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180
           VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180

Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
           NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240

Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
           RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300

Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
           GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360

Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
           TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420

Query: 421 S 421
           S
Sbjct: 421 S 421


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  850 bits (2197), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
           MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60

Query: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120
           ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
Sbjct: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180
           VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180

Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
           NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240

Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
           RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300

Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
           GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360

Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
           TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420

Query: 421 S 421
           S
Sbjct: 421 S 421


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  850 bits (2197), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
           MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60

Query: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120
           ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
Sbjct: 61  ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180
           VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180

Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
           NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240

Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
           RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300

Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
           GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360

Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
           TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420

Query: 421 S 421
           S
Sbjct: 421 S 421


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score =  840 bits (2169), Expect = 0.0
 Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43
           MSPKRIAKRRSPPADAIPKSKKVK                 VSHRSHSTEPGLVLTLGQG
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60

Query: 44  DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103
           DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 61  DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120

Query: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163
           SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180

Query: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223
           VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240

Query: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283
           LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300

Query: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343
           QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360

Query: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
           LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420

Query: 404 VSSGGQHTVLLVKDKEQS 421
           VSSGGQHTVLLVKDKEQS
Sbjct: 421 VSSGGQHTVLLVKDKEQS 438


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score =  834 bits (2155), Expect = 0.0
 Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29
           MSPKRIAKRRSPPADAIPKSKKVK                               VSHRS
Sbjct: 1   MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60

Query: 30  HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89
           HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 61  HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120

Query: 90  SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
           SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180

Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
           NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240

Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
           LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300

Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
           HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360

Query: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
           EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420

Query: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
           EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  142 bits (358), Expect = 6e-34
 Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)

Query: 37  VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92
           +L  G    GQLGLG    E V+E +K     I + V     G  HTV +   G VY+ G
Sbjct: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59

Query: 93  CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
           CND G LG + S +  E V   V L  + +V VS G++HT AL D G+V+ WG   D++G
Sbjct: 60  CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114

Query: 152 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
            +GL+   +   VP  ++   D+ +V+VA G  H + L+   +++  G  + GQLG   +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174

Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
               +   Q L+ LL               + F     G   +F ++  G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219

Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
            QLG       ++P  L S +  ++  V    G+ HT  +  EG  ++ G   YG+LG  
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277

Query: 330 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 386
             + E + P  +  L    V+ +ACG     A V   GR++++G+G N QLGTG   +  
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 387 SPVEMMG 393
           SP  + G
Sbjct: 337 SPFTVKG 343



 Score =  120 bits (300), Expect = 3e-27
 Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84
           H     + G V T G  D+GQLG   +   RKKP  V     +++V    G  HT+ L+ 
Sbjct: 45  HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101

Query: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 143
            GQVY++G + +G LG   S E   +      L + ++VQV+ G  H+ AL+    VF W
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161

Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201
           G  ++  G +GL    KK   P  ++  L +P ++VA+G  H  +LT  G ++  G  + 
Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219

Query: 202 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261
           GQLG   E               VP   +LKS  S+  V      CG   T A++ EG V
Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263

Query: 262 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321
           + FG   Y QLG   T     P+ +     S  + +   G QH +  + S G+ YS G  
Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322

Query: 322 EYGRLGLGEGAEEKS 336
             G+LG G  +  KS
Sbjct: 323 GNGQLGTGSTSNRKS 337



 Score =  104 bits (259), Expect = 2e-22
 Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)

Query: 155 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 214
           +LEP K         ++  V  V  G  H V +  DG +YT GC + GQLG         
Sbjct: 22  VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69

Query: 215 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 268
                            KSR     V   DA       CG   T A++ +G VY +GL +
Sbjct: 70  -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112

Query: 269 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327
             QLG  G+E C  +P+N+ S   S    V  + G +H++ +    + +  G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 328 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
           LG   ++++ P L+  L  +    VA G +  + +T  G +F WG     QLG   + D 
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230

Query: 386 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
           + P   + K L ++ ++ +  G  HT  L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  142 bits (358), Expect = 6e-34
 Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)

Query: 37  VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92
           +L  G    GQLGLG    E V+E +K     I + V     G  HTV +   G VY+ G
Sbjct: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59

Query: 93  CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
           CND G LG + S +  E V   V L  + +V VS G++HT AL D G+V+ WG   D++G
Sbjct: 60  CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114

Query: 152 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
            +GL+   +   VP  ++   D+ +V+VA G  H + L+   +++  G  + GQLG   +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174

Query: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
               +   Q L+ LL               + F     G   +F ++  G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219

Query: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
            QLG       ++P  L S +  ++  V    G+ HT  +  EG  ++ G   YG+LG  
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277

Query: 330 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 386
             + E + P  +  L    V+ +ACG     A V   GR++++G+G N QLGTG   +  
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 387 SPVEMMG 393
           SP  + G
Sbjct: 337 SPFTVKG 343



 Score =  120 bits (300), Expect = 3e-27
 Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84
           H     + G V T G  D+GQLG   +   RKKP  V     +++V    G  HT+ L+ 
Sbjct: 45  HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101

Query: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 143
            GQVY++G + +G LG   S E   +      L + ++VQV+ G  H+ AL+    VF W
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161

Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201
           G  ++  G +GL    KK   P  ++  L +P ++VA+G  H  +LT  G ++  G  + 
Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219

Query: 202 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261
           GQLG   E               VP   +LKS  S+  V      CG   T A++ EG V
Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263

Query: 262 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321
           + FG   Y QLG   T     P+ +     S  + +   G QH +  + S G+ YS G  
Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322

Query: 322 EYGRLGLGEGAEEKS 336
             G+LG G  +  KS
Sbjct: 323 GNGQLGTGSTSNRKS 337



 Score =  104 bits (259), Expect = 2e-22
 Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)

Query: 155 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 214
           +LEP K         ++  V  V  G  H V +  DG +YT GC + GQLG         
Sbjct: 22  VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69

Query: 215 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 268
                            KSR     V   DA       CG   T A++ +G VY +GL +
Sbjct: 70  -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112

Query: 269 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327
             QLG  G+E C  +P+N+ S   S    V  + G +H++ +    + +  G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 328 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
           LG   ++++ P L+  L  +    VA G +  + +T  G +F WG     QLG   + D 
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230

Query: 386 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
           + P   + K L ++ ++ +  G  HT  L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score =  136 bits (342), Expect = 4e-32
 Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
           H +  T    +   G  + GQLGLG      K   + ++ PE V  A  G  HT+  ++ 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 86  GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
           G VY+ G N+EG LG  DT    +  V      + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
              ++ G IGL + +    VP QV +  PV  ++ G  H   +T DG+LY  G  E G+L
Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222

Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
           G   +L  N    Q +    +P+ V+                CG   T  ++ E  VY F
Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266

Query: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
           GL  + QLG  GT       P+ + + ++ T S++  S G++HT  +   G  Y+ G   
Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323

Query: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
           +G+LGLG E      IPTL S      V  VACG
Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 88/301 (29%), Positives = 139/301 (46%), Gaps = 34/301 (11%)

Query: 18  PKSKKVKVSHRSH---STEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQ 71
           P+  K+    R+H   STE G V   G  + GQLGLG+   ER    ++S       + Q
Sbjct: 86  PEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQ 144

Query: 72  AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHT 131
             AG   +  L++ G+++ +G N EG +G       +  VP +V + + V  +S G  H+
Sbjct: 145 LSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHS 202

Query: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTA 189
           A +T DG ++++G     NG +GL   +  +    Q+  ++P  V++VA G +H V+LT 
Sbjct: 203 AFVTTDGELYVFG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT- 259

Query: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
           +  +YT G G+ GQLG    LF              PK +      +  ++      CG 
Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGE 304

Query: 250 YFTFAISHEGHVYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHT 306
             T  I+  G +Y FG   + +LG  G E+    FIP   ++F       V   GG H  
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMV 362

Query: 307 V 307
           V
Sbjct: 363 V 363



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)

Query: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
           + D G VF +G   F +NN       P K        + DVPV  ++ G++H  ++T + 
Sbjct: 8   MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54

Query: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
            LY  G    GQLG         G +  + +   P CV  LK        + + A CG  
Sbjct: 55  KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97

Query: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
            T   +  G+VY  G +N  QLG   TE  + F   ++ SF  S       S G + +  
Sbjct: 98  HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154

Query: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
           +  +G+ +  G    G++GL +      +P  ++    VS ++CG      VT DG ++ 
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213

Query: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
           +G   N +LG         P +++G     QL + +   V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score =  136 bits (342), Expect = 4e-32
 Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
           H +  T    +   G  + GQLGLG      K   + ++ PE V  A  G  HT+  ++ 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 86  GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
           G VY+ G N+EG LG  DT    +  V      + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
              ++ G IGL + +    VP QV +  PV  ++ G  H   +T DG+LY  G  E G+L
Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222

Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
           G   +L  N    Q +    +P+ V+                CG   T  ++ E  VY F
Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266

Query: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
           GL  + QLG  GT       P+ + + ++ T S++  S G++HT  +   G  Y+ G   
Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323

Query: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
           +G+LGLG E      IPTL S      V  VACG
Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 88/301 (29%), Positives = 139/301 (46%), Gaps = 34/301 (11%)

Query: 18  PKSKKVKVSHRSH---STEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQ 71
           P+  K+    R+H   STE G V   G  + GQLGLG+   ER    ++S       + Q
Sbjct: 86  PEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQ 144

Query: 72  AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHT 131
             AG   +  L++ G+++ +G N EG +G       +  VP +V + + V  +S G  H+
Sbjct: 145 LSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHS 202

Query: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTA 189
           A +T DG ++++G     NG +GL   +  +    Q+  ++P  V++VA G +H V+LT 
Sbjct: 203 AFVTTDGELYVFG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT- 259

Query: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
           +  +YT G G+ GQLG    LF              PK +      +  ++      CG 
Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGE 304

Query: 250 YFTFAISHEGHVYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHT 306
             T  I+  G +Y FG   + +LG  G E+    FIP   ++F       V   GG H  
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMV 362

Query: 307 V 307
           V
Sbjct: 363 V 363



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)

Query: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
           + D G VF +G   F +NN       P K        + DVPV  ++ G++H  ++T + 
Sbjct: 8   MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54

Query: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
            LY  G    GQLG         G +  + +   P CV  LK        + + A CG  
Sbjct: 55  KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97

Query: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
            T   +  G+VY  G +N  QLG   TE  + F   ++ SF  S       S G + +  
Sbjct: 98  HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154

Query: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
           +  +G+ +  G    G++GL +      +P  ++    VS ++CG      VT DG ++ 
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213

Query: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
           +G   N +LG         P +++G     QL + +   V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  132 bits (332), Expect = 6e-31
 Identities = 113/404 (27%), Positives = 184/404 (45%), Gaps = 43/404 (10%)

Query: 37  VLTLGQGDVGQLGLGEN----VMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 92
           +L  G   +GQ G+  N    V E +    +S    V +   GG H+V L + G+VY+ G
Sbjct: 1   MLCWGYWSLGQPGISTNLQGIVAEPQVCGFIS-DRSVKEVACGGNHSVFLLEDGEVYTCG 59

Query: 93  CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
            N +G LG +      E +    +  + ++ V+ G+SH+ AL+D G++F WG+  D  G 
Sbjct: 60  LNTKGQLGHEREGNKPEQIGALAD--QHIIHVACGESHSLALSDRGQLFSWGAGSD--GQ 115

Query: 153 IGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPEL 210
           +GL+       VP  +Q      +++V+ GN H + L ADG  +T G    GQLG   E 
Sbjct: 116 LGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE- 174

Query: 211 FANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYH 270
           F ++   Q             + R   G    Q A  GA+ +FA+S  G V+G+G++N  
Sbjct: 175 FPSQASPQ-------------RVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWGMNNAG 220

Query: 271 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 330
           QLG    +    P ++   +  T+  V  S G+ HT  +   G  ++ G    G+LG   
Sbjct: 221 QLGLSDEKDRESPCHVKLLR--TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278

Query: 331 GAEEKSIPTLISRLPA-VSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
             +E +   ++  + + V+ +ACG     A V   G ++A+G G   QLGTG   +   P
Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338

Query: 389 VEMMG-------------KQLENRVVLSVSSGGQHTVLLVKDKE 419
             + G              + +  +V  + SGG  T +L    E
Sbjct: 339 SPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYE 382



 Score =  106 bits (264), Expect = 5e-23
 Identities = 89/316 (28%), Positives = 138/316 (43%), Gaps = 29/316 (9%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLS 83
           +H     E G V T G    GQLG   +  E  KP  +    D  ++    G  H++ LS
Sbjct: 44  NHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGALADQHIIHVACGESHSLALS 100

Query: 84  KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVF 141
             GQ++S+G   +G LG  T+ E S  VP  ++   Q+ ++QVS G+ H  AL  DG+ F
Sbjct: 101 DRGQLFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 159

Query: 142 LWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCG 199
            WG  ++++G +GL +       P +V+    +P+ +VA+G  H   L+  G ++  G  
Sbjct: 160 TWG--KNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMN 217

Query: 200 EQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEG 259
             GQLG   E   +R     ++ L   K V +               CG   T  ++  G
Sbjct: 218 NAGQLGLSDE--KDRESPCHVKLLRTQKVVYIS--------------CGEEHTAVLTKSG 261

Query: 260 HVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLG 319
            V+ FG  +  QLG         P+ +     S  + +   G QH    + S G  Y+ G
Sbjct: 262 GVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA-CGRQHTLAFVPSSGLIYAFG 320

Query: 320 RAEYGRLGLGEGAEEK 335
               G+LG G     K
Sbjct: 321 CGARGQLGTGHTCNVK 336


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  124 bits (311), Expect = 2e-28
 Identities = 93/303 (30%), Positives = 144/303 (47%), Gaps = 30/303 (9%)

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180
           V Q++  +     L+ +GRV+      D       L P       VQ      +VK+A+ 
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDT------LAPQL-----VQGLASRNIVKIAAH 501

Query: 181 ND--HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 238
           +D  H + L A G++Y+ GCG+ G+LG         G    LE    PK +   S G + 
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH--------GDTVPLEE---PKVISAFS-GKQA 549

Query: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 298
                   CG+ ++ AI+ EG +Y +G  NY +LG   +E   IP  +   K      V 
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 299 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASV 356
              G   T+ +   G+ +S G  +YG+LG G G++    P LI +L    V  V CG+  
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRG-GSDGCKTPKLIEKLQDLDVVKVRCGSQF 668

Query: 357 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416
             A+TKDG+V++WG G N +LG G +E    P  + G  L+ + V+ V++G  H + L +
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--LQGKKVIDVAAGSTHCLALTE 726

Query: 417 DKE 419
           D E
Sbjct: 727 DSE 729



 Score =  122 bits (307), Expect = 5e-28
 Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 28/347 (8%)

Query: 79   TVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM---VPGKVELQEKVVQVSAGDSHTAALT 135
            T+    SG +Y +G N  G LG    +EG+++    P +     + VQ+  G+    A+T
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001

Query: 136  DDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-LDVPVVKVASGNDHLVMLTADGDLY 194
             DG+++  G        IG  E +    +   +Q + +  V V SG  H + L+++G++Y
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061

Query: 195  TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254
            + G  E G+LG         G R   +R   P+ +       RG +   D   G   +  
Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDR---PRVI----ESLRG-IEVVDVAAGGAHSAC 4105

Query: 255  ISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK 314
            ++  G +Y +G   Y +LG   +E    P+ + + +      +    G   T+C+  +  
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165

Query: 315  AYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMG 372
             +S G  +YG+LG G G++   +P  I  L    V  V CG+    A+TK G V+ WG G
Sbjct: 4166 VWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224

Query: 373  TNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419
              ++LG G D+    P ++ G  L+ + V+++++G  H V   +D E
Sbjct: 4225 DYHRLGHGSDDHVRRPRQVQG--LQGKKVIAIATGSLHCVCCTEDGE 4269



 Score =  120 bits (302), Expect = 2e-27
 Identities = 104/364 (28%), Positives = 170/364 (46%), Gaps = 41/364 (11%)

Query: 69   VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM-VPGKVELQE--KVVQVS 125
            +++ +A G+ +    ++ +V+ +G ND+  LG    ++GS++ VP   E      VVQV+
Sbjct: 2943 LIRKKAAGLESAATIRT-KVFVWGLNDKDQLG---GLKGSKIKVPSFSETLSALNVVQVA 2998

Query: 126  AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD------VPVVKVAS 179
             G     A+T +G+V+  G     NG +GL   +    VP+  Q+       V  V V S
Sbjct: 2999 GGSKSLFAVTVEGKVYACGEA--TNGRLGL--GISSGTVPIPRQITALSSYVVKKVAVHS 3054

Query: 180  GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCV-MLKSRGSRG 238
            G  H   LT DG +++ G G+ G+LG    +  ++           P+ +  LK++    
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-----------PRLIEALKTK---- 3099

Query: 239  HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 298
              R +D  CG+  + A++  G +Y +GL  Y +LG     +   P+ +          V 
Sbjct: 3100 --RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVA 3157

Query: 299  FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASV 356
                   T+ +  EG  +S G  ++G+LG G G+E  +IP  I RL    V  + CGA  
Sbjct: 3158 CGSRDAQTLALTDEGLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQF 3216

Query: 357  GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416
              A+TK G V+ WG G  ++LG G D     P  + G  L  + ++ V+ G  H  L V 
Sbjct: 3217 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG--LRGKKIVHVAVGALH-CLAVT 3273

Query: 417  DKEQ 420
            D  Q
Sbjct: 3274 DSGQ 3277



 Score =  120 bits (301), Expect = 2e-27
 Identities = 115/387 (29%), Positives = 168/387 (43%), Gaps = 36/387 (9%)

Query: 37   VLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLSKSGQVYSFGCN 94
            V   G  D  QLG G    + K P+        +VVQ   G      ++  G+VY+ G  
Sbjct: 2961 VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019

Query: 95   DEGALGRDTSVEGSEMVPGKVELQE----KVVQVSAGDSHTAALTDDGRVFLWGSFRDNN 150
              G LG   S  G+  +P ++        K V V +G  H  ALT DG+VF WG   D  
Sbjct: 3020 TNGRLGLGIS-SGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD-- 3076

Query: 151  GVIGLLEPMKKSMVPVQVQLDVPVVK-VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
            G +G    M      +   L    ++ +A G+ H   LT+ G+LYT G GE G+LG    
Sbjct: 3077 GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN 3136

Query: 210  LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF--TFAISHEGHVYGFGLS 267
                          L PK V +      GH   Q A CG+    T A++ EG V+ +G  
Sbjct: 3137 TTQ-----------LKPKMVKVLL----GHRVIQVA-CGSRDAQTLALTDEGLVFSWGDG 3180

Query: 268  NYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327
            ++ +LG  G+E C IPQN+          +    G   ++ +   G  ++ G+ +Y RLG
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFSLALTKSGVVWTWGKGDYFRLG 3238

Query: 328  LGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
             G     +  P ++  L    +  VA GA    AVT  G+V+AWG   + Q G G     
Sbjct: 3239 HGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3297

Query: 386  WSPVEMMGKQLENRVVLSVSSGGQHTV 412
              P  + G  LE + +  V+ G  H+V
Sbjct: 3298 RKPTLVQG--LEGQKITRVACGSSHSV 3322



 Score =  114 bits (284), Expect = 2e-25
 Identities = 110/398 (27%), Positives = 162/398 (40%), Gaps = 37/398 (9%)

Query: 35   GLVLTLGQGDVGQLGLGENVMER-KKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGC 93
            G +   G    GQLG  E    +   P         VQ   G      ++  G++Y+ G 
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011

Query: 94   NDEGALGRDTSVEGSEMVPGKVELQE------KVVQVSAGDSHTAALTDDGRVFLWGSFR 147
               G LG    + G+E V     L+       K V V++G  H  AL+ +G V+ WG   
Sbjct: 4012 GAGGRLG----IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067

Query: 148  DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRV 207
            D     G   P  +  V ++    + VV VA+G  H   +TA GDLYT G G  G+LG  
Sbjct: 4068 DGKLGHGNRSPCDRPRV-IESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126

Query: 208  PELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA--YFTFAISHEGHVYGFG 265
                         E  L PK V       +GH R  D  CG+    T  ++ +  V+ +G
Sbjct: 4127 DS-----------EDQLKPKLV----EALQGH-RVVDIACGSGDAQTLCLTDDDTVWSWG 4170

Query: 266  LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
              +Y +LG  G++ C +P  + S        V    G   +V +   G  Y+ G+ +Y R
Sbjct: 4171 DGDYGKLGRGGSDGCKVPMKIDSLTGL--GVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228

Query: 326  LGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE 383
            LG G     +  P  +  L    V ++A G+      T+DG V+ WG     QLG G   
Sbjct: 4229 LGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287

Query: 384  DAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
                P   +   L+ + V  V+ G  HT+     K  S
Sbjct: 4288 AIQRP--RLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323



 Score =  108 bits (270), Expect = 9e-24
 Identities = 95/332 (28%), Positives = 152/332 (45%), Gaps = 29/332 (8%)

Query: 32   TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEA---GGMHTVCLSKSGQV 88
            T  G +   G G  G+LG+G          L SI    ++  A   GG H + LS  G+V
Sbjct: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060

Query: 89   YSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLWGSF 146
            YS+G  ++G LG           P  +E     +VV V+AG +H+A +T  G ++ WG  
Sbjct: 4061 YSWGEAEDGKLGHGNRSPCDR--PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4118

Query: 147  RDNN-GVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
            R    G     + +K  +V       V  +   SG+   + LT D  +++ G G+ G+LG
Sbjct: 4119 RYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4178

Query: 206  RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 265
            R        GG  G +   VP  + + S    G V+ +   CG+ F+ A++  G VY +G
Sbjct: 4179 R--------GGSDGCK---VP--MKIDSLTGLGVVKVE---CGSQFSVALTKSGAVYTWG 4222

Query: 266  LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
              +YH+LG    +    P+ +   +   K  +  + G  H VC   +G+ Y+ G  + G+
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQG--KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280

Query: 326  LGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
            LG G        P L++ L    V+ VACG++
Sbjct: 4281 LGDGT-TNAIQRPRLVAALQGKKVNRVACGSA 4311



 Score =  103 bits (257), Expect = 3e-22
 Identities = 94/342 (27%), Positives = 157/342 (45%), Gaps = 36/342 (10%)

Query: 32   TEPGLVLTLGQGDVGQLGLGENV----MERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 87
            T  G V   G+   G+LGLG +     + R+  AL S     V   +GG H   L+  G+
Sbjct: 3008 TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK 3067

Query: 88   VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFR 147
            V+S+G  D+G LG  + +   +    +    +++  ++ G SH+AALT  G ++ WG   
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGL-- 3125

Query: 148  DNNGVIGLL------EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201
               G  G L        +K  MV V +   V  V   S +   + LT +G +++ G G+ 
Sbjct: 3126 ---GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182

Query: 202  GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 261
            G+LG        RGG +G     +P+   ++    +G  + +   CGA F+ A++  G V
Sbjct: 3183 GKLG--------RGGSEGCN---IPQ--NIERLNGQGVCQIE---CGAQFSLALTKSGVV 3226

Query: 262  YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 321
            + +G  +Y +LG         PQ +   +   K  V  + G  H + +   G+ Y+ G  
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRG--KKIVHVAVGALHCLAVTDSGQVYAWGDN 3284

Query: 322  EYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVT 361
            ++G+ G G     +  PTL+  L    ++ VACG+S   A T
Sbjct: 3285 DHGQQGNGTTTVNRK-PTLVQGLEGQKITRVACGSSHSVAWT 3325



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 82/322 (25%), Positives = 148/322 (45%), Gaps = 47/322 (14%)

Query: 70  VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE-----MVPGKVELQEKVVQV 124
           + A + G H + L+ +G+VYS+GC D G LG   +V   E        GK +  + VV +
Sbjct: 498 IAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGK-QAGKHVVHI 556

Query: 125 SAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ----LDVPVVKVASG 180
           + G +++AA+T +G ++ WG  R N G +G     +   +P+ V     L V  V   SG
Sbjct: 557 ACGSTYSAAITAEGELYTWG--RGNYGRLG-HGSSEDEAIPMLVAGLKGLKVIDVACGSG 613

Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
           +   + +T +G +++ G G+ G+LG        RGG  G +    PK +          V
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLG--------RGGSDGCK---TPKLIEKLQDLDVVKV 662

Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
           R     CG+ F+ A++ +G VY +G  +  +LG    E    P+ L   +   K  +  +
Sbjct: 663 R-----CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQG--KKVIDVA 715

Query: 301 GGQHHTVCMDSEGKAYSLGRAE----YGRLGLGEGAEEKSIPTLISRLPAVSSVACGASV 356
            G  H + +  + + +S G  +    +  L + +  E  ++P L ++   +  +ACG + 
Sbjct: 716 AGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK-PEPAALPGLDTK--HIVGIACGPA- 771

Query: 357 GYAVTKDGRVFAWGMGTNYQLG 378
                   + FAW   + + +G
Sbjct: 772 --------QSFAWSSCSEWSIG 785



 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 67/239 (28%), Positives = 98/239 (41%), Gaps = 19/239 (7%)

Query: 181  NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240
            +D  +     G +Y  G   +GQLG          G +G +  +   C  L +      +
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG----------GIEGAKVKVPTPCEALAT------L 3985

Query: 241  RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300
            R      G    FA++ +G +Y  G     +LG  GTES   P  L S ++     V  +
Sbjct: 3986 RPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVN 4045

Query: 301  GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGY 358
             G  H + + SEG+ YS G AE G+LG G        P +I  L  +    VA G +   
Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIESLRGIEVVDVAAGGAHSA 4104

Query: 359  AVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
             VT  G ++ WG G   +LG    ED   P  +   Q    V ++  SG   T+ L  D
Sbjct: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 85/314 (27%), Positives = 139/314 (44%), Gaps = 41/314 (13%)

Query: 21   KKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPE-DVVQAEAG 75
            KKV V+    H    +  G V + G+ + G+LG G      +   + S+   +VV   AG
Sbjct: 4040 KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4099

Query: 76   GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVS--AGDSHT 131
            G H+ C++ +G +Y++G    G LG   S +  ++ P  VE  +  +VV ++  +GD+ T
Sbjct: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSED--QLKPKLVEALQGHRVVDIACGSGDAQT 4157

Query: 132  AALTDDGRVFLWG----SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVML 187
              LTDD  V+ WG          G  G   PMK     +     + VVKV  G+   V L
Sbjct: 4158 LCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMK-----IDSLTGLGVVKVECGSQFSVAL 4212

Query: 188  TADGDLYTLGCGEQGQLGRVPELFANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAF 246
            T  G +YT G G+  +LG   +    R  + QGL+     K + + +             
Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQG---KKVIAIAT------------- 4256

Query: 247  CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
             G+      + +G VY +G ++  QLG   T +   P+ + + +    + V  + G  HT
Sbjct: 4257 -GSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV--ACGSAHT 4313

Query: 307  VCMDSEGKAYSLGR 320
            +   S  K  S G+
Sbjct: 4314 LAW-STSKPASAGK 4326



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 75/269 (27%), Positives = 119/269 (44%), Gaps = 34/269 (12%)

Query: 21   KKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEA 74
            KKV V     H +  T  G V + G+GD G+LG     M   KP L+     + +     
Sbjct: 3048 KKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSR-MNCDKPRLIEALKTKRIRDIAC 3106

Query: 75   GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAG--DSHTA 132
            G  H+  L+ SG++Y++G  + G LG   +    +    KV L  +V+QV+ G  D+ T 
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTL 3166

Query: 133  ALTDDGRVFLWGSFRDNNGVIGLL--EPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLT 188
            ALTD+G VF WG     +G  G L     +   +P  ++      V ++  G    + LT
Sbjct: 3167 ALTDEGLVFSWG-----DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221

Query: 189  ADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 248
              G ++T G G+  +LG   ++   +           P+ V     G RG  +      G
Sbjct: 3222 KSGVVWTWGKGDYFRLGHGSDVHVRK-----------PQVV----EGLRGK-KIVHVAVG 3265

Query: 249  AYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
            A    A++  G VY +G +++ Q G   T
Sbjct: 3266 ALHCLAVTDSGQVYAWGDNDHGQQGNGTT 3294



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 48/119 (40%), Positives = 66/119 (55%), Gaps = 9/119 (7%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLSKSGQVY 89
           TE G V + G GD G+LG G +    K P L+   +D  VV+   G   ++ L+K GQVY
Sbjct: 621 TENGQVWSWGDGDYGKLGRGGSD-GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 679

Query: 90  SFGCNDEGALGRDTS--VEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGS 145
           S+G  D   LG  T   V   +++ G   LQ +KV+ V+AG +H  ALT+D  V  WGS
Sbjct: 680 SWGKGDNQRLGHGTEEHVRYPKLLEG---LQGKKVIDVAAGSTHCLALTEDSEVHSWGS 735



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 8/177 (4%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGMHTVCLSKSGQ 87
           T  G + T G+G+ G+LG G +  +   P LV+  + +    V   +G   T+ ++++GQ
Sbjct: 567 TAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ 625

Query: 88  VYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLWGSF 146
           V+S+G  D G LGR  S +G +      +LQ+  VV+V  G   + ALT DG+V+ WG  
Sbjct: 626 VWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG 684

Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 203
            +     G  E ++   +   +Q    V+ VA+G+ H + LT D ++++ G  +Q Q
Sbjct: 685 DNQRLGHGTEEHVRYPKLLEGLQ-GKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score =  109 bits (273), Expect = 4e-24
 Identities = 108/386 (27%), Positives = 172/386 (44%), Gaps = 73/386 (18%)

Query: 71  QAEAGGMHTVCLSKSGQVYSF-----GCNDEGALGRDTSVEGSEMVPGKVE-LQEKVV-Q 123
           Q  AG  H   ++   ++Y++     G    G LG     + S   P  VE LQ K + Q
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGD--KASYRQPKHVEKLQGKAIRQ 430

Query: 124 VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGL--------LEPMKKSMVPVQVQLDVPVV 175
           VS GD  T  +TD+G+++ +GS  D  G +G+        LEPM+ +       L  PV 
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGS--DYYGCMGVDKVAGPEVLEPMQLNFF-----LSNPVE 483

Query: 176 KVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRG 235
           +V+ G++H+V+LT + ++Y+ GCGE G+LG       +       +++ VPK +++ +  
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLG-----LDSEEDYYTPQKVDVPKALIIVA-- 536

Query: 236 SRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLG----------------TPGTES 279
                      CG   TF ++  G V   GL+ +++LG                 P T S
Sbjct: 537 ---------VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS 587

Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
             + + L+ +K  T      + G+ HT  +D  G+  + G  + G+LG+G   +   I  
Sbjct: 588 FTLAKQLSFYKIRT-----IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINL 642

Query: 340 LISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT-------GQDEDAWSPVE 390
           L   L    V  V+CG     A T D  +FAWG G N +L         G D     P  
Sbjct: 643 LGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRP 702

Query: 391 MMGKQLENRVVLSVSSGGQHTVLLVK 416
           + G       V  +S  G HT+L+V+
Sbjct: 703 IFGSL---HHVPDLSCRGWHTILIVE 725



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 69/265 (26%), Positives = 105/265 (39%), Gaps = 36/265 (13%)

Query: 32  TEPGLVLTLGQGDVGQLGL----GENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 87
           T+ G +   G    G +G+    G  V+E  +     +   V Q   G  H V L+++ +
Sbjct: 442 TDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-LSNPVEQVSCGDNHVVVLTRNKE 500

Query: 88  VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLWG- 144
           VYS+GC + G LG D+  E     P KV++ +   +V V  G   T  LT  G+V   G 
Sbjct: 501 VYSWGCGEYGRLGLDS--EEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGL 558

Query: 145 ----SFRDNNGVIGLLEPMKKSMVPVQVQLDV-------PVVKVASGNDHLVMLTADGDL 193
                   N  + G++       VP      +        +  +A G  H   +   G L
Sbjct: 559 NEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRL 618

Query: 194 YTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTF 253
            T GC + GQLG       N   R G+  L  P        G +  +R     CG  FT 
Sbjct: 619 LTFGCNKCGQLG-----VGNYKKRLGINLLGGP-------LGGKQVIRVS---CGDEFTI 663

Query: 254 AISHEGHVYGFGLSNYHQLGTPGTE 278
           A + + H++ +G     +L    TE
Sbjct: 664 AATDDNHIFAWGNGGNGRLAMTPTE 688



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 15/147 (10%)

Query: 283 PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL-----GRAEYGRLGLGEGAEEKSI 337
           PQ L   K+   +    +G  H  V +  E + Y+      G   +G+LG G+ A  +  
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAV-VTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ- 416

Query: 338 PTLISRLP--AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 395
           P  + +L   A+  V+CG      VT +G+++A+G  ++Y    G D+ A  P  +   Q
Sbjct: 417 PKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFG--SDYYGCMGVDKVA-GPEVLEPMQ 473

Query: 396 LE---NRVVLSVSSGGQHTVLLVKDKE 419
           L    +  V  VS G  H V+L ++KE
Sbjct: 474 LNFFLSNPVEQVSCGDNHVVVLTRNKE 500



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 4/77 (5%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGGMHTVCL 82
           +H +   E G +LT G    GQLG+G N  +R    L+  P   + V++   G   T+  
Sbjct: 607 THTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAA 665

Query: 83  SKSGQVYSFGCNDEGAL 99
           +    ++++G    G L
Sbjct: 666 TDDNHIFAWGNGGNGRL 682


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191

Query: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247

Query: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307

Query: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367

Query: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420

Query: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479

Query: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
            L+      V+ G  H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271

Query: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191

Query: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247

Query: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307

Query: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367

Query: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420

Query: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479

Query: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
            L+      V+ G  H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271

Query: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331

Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score =  100 bits (248), Expect = 3e-21
 Identities = 90/318 (28%), Positives = 148/318 (46%), Gaps = 31/318 (9%)

Query: 35   GLVLTLGQGDVGQLGLGE----NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYS 90
            G VL  G+G  G+LG G     +V+         +   +V +     H++ L++SG+V+S
Sbjct: 4046 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105

Query: 91   FGCNDEGALGRDTSVEGSEMVPGKVE-LQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRD 148
            +G  D G LG   S    +  P ++E LQ E+VVQ+S G  H+A +T DG++F +G+   
Sbjct: 4106 WGDGDYGKLGHGNS--DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--G 4161

Query: 149  NNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL-YTLGCGEQGQLGR 206
            + G +GL     K +      L+   + +VA G +H + ++ADG + +  G G+ G+LG 
Sbjct: 4162 DYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG- 4220

Query: 207  VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
                  N   +   +++ V   + +K              CG  F+ A++ +GHVY FG 
Sbjct: 4221 ----LGNSTAKSSPQKIDVLCGIGIKK-----------VACGTQFSVALTKDGHVYTFGQ 4265

Query: 267  SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326
                 L      +   PQ +          V    G  HT+ + S G  Y+ G    G+L
Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV--GAEHTLALASNGDVYAWGSNSEGQL 4323

Query: 327  GLGEGAEEKSIPTLISRL 344
            GLG     +  PTL++ L
Sbjct: 4324 GLGHTNHVRE-PTLVTGL 4340



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 93/348 (26%), Positives = 160/348 (45%), Gaps = 37/348 (10%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIP----EDVVQAEAGGMHTVCLSKSGQVYS 90
           G V   G+G  G+LGLG++  +     L   P    + V  ++    HT+  +  G+V+S
Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481

Query: 91  FGCNDEGALGRDTSVEGSEMVPGKVE--LQEKVVQ-VSAGDSHTAALTDDGRVFLWGSFR 147
           +G  D G LG   S   ++  P  ++  LQ KVV  VSAG  H+AA+T+DG ++ WG   
Sbjct: 482 WGDGDYGKLGHGNS--STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWG--E 537

Query: 148 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG-DLYTLGCGEQGQLGR 206
            + G +G  +   ++ +P  V+    V +V+ G+ H + L+ DG  +++ G G+ G+L  
Sbjct: 538 GDFGRLGHGDSNSRN-IPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKL-- 594

Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
                    G     R+  PK +       +G +  +    G+  + A++  G VY +G 
Sbjct: 595 ---------GHGDTNRVYKPKVI----EALQG-MFIRKVCAGSQSSLALTSTGQVYAWGC 640

Query: 267 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326
                LG   +E+  +   L     +T+  V  S G  H + +  + + Y+ G    G+ 
Sbjct: 641 GAC--LGCGSSEATALRPKLIEELAATRI-VDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697

Query: 327 GLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVT---KDGRVFAW 369
           G G      + P  +S L   A+  ++ G S   A T   +D +V AW
Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 83/284 (29%), Positives = 132/284 (46%), Gaps = 25/284 (8%)

Query: 27   HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKS 85
            H    TE G V + G GD G+LG G +  +R+   + ++  E+VVQ   G  H+  ++  
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152

Query: 86   GQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLW 143
            G++++FG  D G LG   +   ++ +P +V   E  ++ QV+ G +HT A++ DG + +W
Sbjct: 4153 GKLFTFGNGDYGRLGLGNT--SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSM-VW 4209

Query: 144  GSFRDNNGVIGL-LEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 202
                 + G +GL     K S   + V   + + KVA G    V LT DG +YT G   Q 
Sbjct: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG---QD 4266

Query: 203  QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 262
            +L  +PE  A    R     +L               V  +D   GA  T A++  G VY
Sbjct: 4267 RLIGLPEGRARNHNRPQQIPVL-------------AGVIIEDVAVGAEHTLALASNGDVY 4313

Query: 263  GFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
             +G ++  QLG   T     P  +T  +   K+    S G+ H+
Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQG--KNVRQISAGRCHS 4355



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 109/383 (28%), Positives = 163/383 (42%), Gaps = 42/383 (10%)

Query: 41   GQGDVGQLG-LGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGAL 99
            G G  GQL   G NVM    PA         Q   G   T  +  +G V + G    G L
Sbjct: 4003 GAGRHGQLAEAGRNVMV---PAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059

Query: 100  GRDTSVEGSEM-----VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG 154
            G+  S +   +     + G V  Q  +V     D H+ ALT+ G VF WG    + G +G
Sbjct: 4060 GQGNSDDLHVLTVISALQGFVVTQ--LVTSCGSDGHSMALTESGEVFSWGD--GDYGKLG 4115

Query: 155  LLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFA 212
                 ++   P Q++      VV+++ G  H  ++T+DG L+T G G+ G+LG       
Sbjct: 4116 HGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG-----LG 4169

Query: 213  NRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQ 271
            N   ++  ER+   +   +      G V      CG   T A+S +G  V+ FG  +Y +
Sbjct: 4170 NTSNKKLPERVTALEGYQI------GQVA-----CGLNHTLAVSADGSMVWAFGDGDYGK 4218

Query: 272  LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEG 331
            LG   + +   PQ +          V    G   +V +  +G  Y+ G+     +GL EG
Sbjct: 4219 LGLGNSTAKSSPQKIDVLCGIGIKKVAC--GTQFSVALTKDGHVYTFGQDRL--IGLPEG 4274

Query: 332  -AEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
             A   + P  I  L  V    VA GA    A+  +G V+AWG  +  QLG G       P
Sbjct: 4275 RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREP 4334

Query: 389  VEMMGKQLENRVVLSVSSGGQHT 411
              + G Q +N  V  +S+G  H+
Sbjct: 4335 TLVTGLQGKN--VRQISAGRCHS 4355



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 99/364 (27%), Positives = 153/364 (42%), Gaps = 37/364 (10%)

Query: 59  KPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
           +P L     D    EAG   T  +S  G V + G    G LG   S   S +     E  
Sbjct: 395 QPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPH 454

Query: 119 EKVVQVSAG---DSHTAALTDDGRVFLWGSF---RDNNGVIGLLEPMKKSMVPVQVQLDV 172
             + +VS+    D HT A T +G VF WG     +  +G     +  K    P+Q ++  
Sbjct: 455 RSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKV-- 512

Query: 173 PVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLK 232
            VV V++G  H   +T DG+LYT G G+ G+LG       N           +P   ++K
Sbjct: 513 -VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRN-----------IP--TLVK 558

Query: 233 SRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291
              + G V      CG+  T A+S +G  V+ FG  +  +LG   T   + P+ + + + 
Sbjct: 559 DISNVGEVS-----CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613

Query: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSS 349
                V    G   ++ + S G+ Y+ G      LG G        P LI  L A  +  
Sbjct: 614 MFIRKV--CAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVD 669

Query: 350 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE-DAWSPVEMMGKQLENRVVLSVSSGG 408
           V+ G S   A++ D  V+AWG  +  Q G G        P ++ G  L+   +  +S+G 
Sbjct: 670 VSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG--LDGIAIQQISAGT 727

Query: 409 QHTV 412
            H++
Sbjct: 728 SHSL 731



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 78/259 (30%), Positives = 115/259 (44%), Gaps = 27/259 (10%)

Query: 20  SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGG 76
           S K    H    T  G V + G GD G+LG G N   +K P L+  P   + VV   AG 
Sbjct: 462 SSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHG-NSSTQKYPKLIQGPLQGKVVVCVSAGY 520

Query: 77  MHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTD 136
            H+  +++ G++Y++G  D G LG   S   S  +P  V+    V +VS G SHT AL+ 
Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGHGDS--NSRNIPTLVKDISNVGEVSCGSSHTIALSK 578

Query: 137 DGRVFLWGSFRDNNGVIGLLEPMK--KSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 194
           DGR  +W     +NG +G  +  +  K  V ++    + + KV +G+   + LT+ G +Y
Sbjct: 579 DGRT-VWSFGGGDNGKLGHGDTNRVYKPKV-IEALQGMFIRKVCAGSQSSLALTSTGQVY 636

Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254
             GCG            A  G        L PK +           R  D   G     A
Sbjct: 637 AWGCG------------ACLGCGSSEATALRPKLI-----EELAATRIVDVSIGDSHCLA 679

Query: 255 ISHEGHVYGFGLSNYHQLG 273
           +SH+  VY +G ++  Q G
Sbjct: 680 LSHDNEVYAWGNNSMGQCG 698



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 79/288 (27%), Positives = 127/288 (44%), Gaps = 39/288 (13%)

Query: 140  VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCG 199
            V+LWG+ R       L E  +  MVP          +V  G +   ++ A+G +   G G
Sbjct: 3999 VYLWGAGRHGQ----LAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEG 4054

Query: 200  EQGQLGRVPELFANRGGRQGLERLLVPKCV-------MLKSRGSRGHVRFQDAFCGAYFT 252
              G+LG+        G    L  L V   +       ++ S GS GH            +
Sbjct: 4055 SYGRLGQ--------GNSDDLHVLTVISALQGFVVTQLVTSCGSDGH------------S 4094

Query: 253  FAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 312
             A++  G V+ +G  +Y +LG   ++    P+ + + +   +  V  S G  H+  + S+
Sbjct: 4095 MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG--EEVVQMSCGFKHSAVVTSD 4152

Query: 313  GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDG-RVFAW 369
            GK ++ G  +YGRLGLG     K +P  ++ L    +  VACG +   AV+ DG  V+A+
Sbjct: 4153 GKLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211

Query: 370  GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
            G G   +LG G      SP ++    L    +  V+ G Q +V L KD
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKI--DVLCGIGIKKVACGTQFSVALTKD 4257



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 67/208 (32%), Positives = 100/208 (48%), Gaps = 15/208 (7%)

Query: 8    KRRSPPADAIPKSKKVKVS----HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALV 63
            +RR    +A+   + V++S    H +  T  G + T G GD G+LGLG N   +K P  V
Sbjct: 4122 QRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLG-NTSNKKLPERV 4180

Query: 64   SIPE--DVVQAEAGGMHTVCLSKSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120
            +  E   + Q   G  HT+ +S  G  V++FG  D G LG   S   S      V     
Sbjct: 4181 TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG 4240

Query: 121  VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKS---MVPVQVQLDVPVVKV 177
            + +V+ G   + ALT DG V+ +G  R    +IGL E   ++      + V   V +  V
Sbjct: 4241 IKKVACGTQFSVALTKDGHVYTFGQDR----LIGLPEGRARNHNRPQQIPVLAGVIIEDV 4296

Query: 178  ASGNDHLVMLTADGDLYTLGCGEQGQLG 205
            A G +H + L ++GD+Y  G   +GQLG
Sbjct: 4297 AVGAEHTLALASNGDVYAWGSNSEGQLG 4324



 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 88/354 (24%), Positives = 154/354 (43%), Gaps = 52/354 (14%)

Query: 82  LSKSGQVYSFGCNDEGAL--GRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGR 139
           +S++ +VY +G N    L  G    +   ++ P   + Q     + AG   T  ++ DG 
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT----IEAGQYCTFVISTDGS 423

Query: 140 VFLWGSFRDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGND-HLVMLTADGDLYT 195
           V   G  + + G +GL +   +S +     +    +  V  + G+D H +  T +G++++
Sbjct: 424 VRACG--KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481

Query: 196 LGCGEQGQLG-------RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 248
            G G+ G+LG       + P+L   +G  QG       K V+  S G R           
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLI--QGPLQG-------KVVVCVSAGYR----------- 521

Query: 249 AYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
              + A++ +G +Y +G  ++ +LG   + S  IP  +    N  +     S G  HT+ 
Sbjct: 522 --HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGE----VSCGSSHTIA 575

Query: 309 MDSEGKA-YSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 365
           +  +G+  +S G  + G+LG G+       P +I  L    +  V  G+    A+T  G+
Sbjct: 576 LSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQ 634

Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419
           V+AWG G    LG G  E      +++ +    R+V  VS G  H + L  D E
Sbjct: 635 VYAWGCGA--CLGCGSSEATALRPKLIEELAATRIV-DVSIGDSHCLALSHDNE 685



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 57/185 (30%), Positives = 89/185 (48%), Gaps = 12/185 (6%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSG 86
           H +  TE G + T G+GD G+LG G++   R  P LV    +V +   G  HT+ LSK G
Sbjct: 522 HSAAVTEDGELYTWGEGDFGRLGHGDS-NSRNIPTLVKDISNVGEVSCGSSHTIALSKDG 580

Query: 87  Q-VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLW 143
           + V+SFG  D G LG   +       P  +E  +   + +V AG   + ALT  G+V+ W
Sbjct: 581 RTVWSFGGGDNGKLGHGDT--NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638

Query: 144 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 201
           G        +G       ++ P  ++      +V V+ G+ H + L+ D ++Y  G    
Sbjct: 639 GC----GACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSM 694

Query: 202 GQLGR 206
           GQ G+
Sbjct: 695 GQCGQ 699



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 39/110 (35%), Positives = 54/110 (49%), Gaps = 11/110 (10%)

Query: 32   TEPGLVLTLGQGDVGQLGLGEN-VMERKKPALVSIPEDVV--QAEAGGMHTVCLSKSGQV 88
            T+ G V T GQ  +  +GL E       +P  + +   V+      G  HT+ L+ +G V
Sbjct: 4255 TKDGHVYTFGQDRL--IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDV 4312

Query: 89   YSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVV-QVSAGDSHTAALT 135
            Y++G N EG   LG    V    +V G   LQ K V Q+SAG  H+AA T
Sbjct: 4313 YAWGSNSEGQLGLGHTNHVREPTLVTG---LQGKNVRQISAGRCHSAAWT 4359


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 92/334 (27%), Positives = 161/334 (48%), Gaps = 34/334 (10%)

Query: 49  GLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGS 108
           G     ++R++ A  S   +++QA +G  H++ L  + +V S G N  G LGR  +  G 
Sbjct: 6   GADSRELQRRRTA-GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64

Query: 109 EMVPGKVELQEKVVQ--VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
             +P  ++  E ++   VS G  H+ A+   GRVF WG+   + G +G+ E  + S  P 
Sbjct: 65  --LPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPK 120

Query: 167 QVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLL 224
           ++    D+ +++V+ G+ H + L+ D  +++ G    GQLG   E F ++   Q      
Sbjct: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE-FPSQASPQ------ 173

Query: 225 VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE---SCF 281
                  + R   G    Q A  GA+ +FA+S  G  +G+G ++  QL   G        
Sbjct: 174 -------RVRSLEGIPLAQVAAGGAH-SFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225

Query: 282 IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLI 341
            P ++ + KN    ++  S G  HT  +  +GK ++ G    G+LG     E++  P L+
Sbjct: 226 KPLSVGALKNLGVVYI--SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG-PQLV 282

Query: 342 SRLPA-VSSVACGA--SVGYAVTKDGRVFAWGMG 372
            R+   VS + CG+  ++ Y  T  G+V ++G G
Sbjct: 283 ERIDGLVSQIDCGSYHTLAYVHT-TGQVVSFGHG 315



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 77/238 (32%), Positives = 107/238 (44%), Gaps = 25/238 (10%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLSKSGQVYSFG 92
           G V   G G  GQLG+GE       P  +    D  ++Q   G  H++ LSK  QV+S+G
Sbjct: 94  GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153

Query: 93  CNDEGALGRDTSVEGSEMVPGKVELQEKV--VQVSAGDSHTAALTDDGRVFLWGSFRDNN 150
            N  G LG       S+  P +V   E +   QV+AG +H+ AL+  G  F WGS     
Sbjct: 154 KNSHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212

Query: 151 GVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
             +       +S  P+ V    ++ VV ++ G+ H  +LT DG ++T G    GQLG  P
Sbjct: 213 LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272

Query: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH-EGHVYGFG 265
                + G Q +ER+              G V   D  CG+Y T A  H  G V  FG
Sbjct: 273 T--PEKRGPQLVERI-------------DGLVSQID--CGSYHTLAYVHTTGQVVSFG 313



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 30/252 (11%)

Query: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGR----QGLERLLVPKCV 229
           +++ ASG  H ++L  +  + + G   +GQLGR     A RG      Q LE L+V    
Sbjct: 25  LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG---AQRGELPEPIQALETLIVDL-- 79

Query: 230 MLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG-TESCFIPQNLTS 288
                            CG   + A+ H+G V+ +G  +  QLG     E  F P+ + +
Sbjct: 80  ---------------VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124

Query: 289 FKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV- 347
             N  K  +  S G +H++ +  + + +S G+  +G+LGLG+    ++ P  +  L  + 
Sbjct: 125 L-NDIKI-IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182

Query: 348 -SSVACGASVGYAVTKDGRVFAWGMGTNYQLG-TGQDEDAWSPVEMMGKQLENRVVLSVS 405
            + VA G +  +A++  G  F WG  +  QL  +G++    S   +    L+N  V+ +S
Sbjct: 183 LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYIS 242

Query: 406 SGGQHTVLLVKD 417
            G  HT +L +D
Sbjct: 243 CGDAHTAVLTQD 254



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 77/307 (25%), Positives = 135/307 (43%), Gaps = 38/307 (12%)

Query: 120 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMV-PVQVQLDVPVVKVA 178
           +++Q ++G+ H+  L  + RV   G   ++ G +G     +  +  P+Q    + V  V+
Sbjct: 24  ELLQAASGERHSLLLLTNHRVLSCGD--NSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81

Query: 179 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 238
            G +H + +   G ++  G G +GQLG + E           E    PK +M     +  
Sbjct: 82  CGKEHSLAVCHKGRVFAWGAGSEGQLG-IGEF---------KEISFTPKKIM-----TLN 126

Query: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSW 296
            ++     CG Y + A+S +  V+ +G +++ QLG  G E  S   PQ + S +    + 
Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIPLAQ 185

Query: 297 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG--EGAEEKSIPTLISRLP--AVSSVAC 352
           V   G   H+  +   G ++  G    G+L L       + + P  +  L    V  ++C
Sbjct: 186 VAAGGA--HSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243

Query: 353 GASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV-EMMGKQLENRV---VLSVSSGG 408
           G +    +T+DG+VF +G   + QLG       +SP  E  G QL  R+   V  +  G 
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLG-------YSPTPEKRGPQLVERIDGLVSQIDCGS 296

Query: 409 QHTVLLV 415
            HT+  V
Sbjct: 297 YHTLAYV 303



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 6/185 (3%)

Query: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291
           ++ GS G    Q A  G   +  +     V   G ++  QLG  G +   +P+ + + + 
Sbjct: 16  RTAGSPGAELLQAA-SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74

Query: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--S 349
                V  S G+ H++ +  +G+ ++ G    G+LG+GE  E    P  I  L  +    
Sbjct: 75  LIVDLV--SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQ 132

Query: 350 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQ 409
           V+CG     A++KD +VF+WG  ++ QLG G++  + +  + + + LE   +  V++GG 
Sbjct: 133 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV-RSLEGIPLAQVAAGGA 191

Query: 410 HTVLL 414
           H+  L
Sbjct: 192 HSFAL 196



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 6/123 (4%)

Query: 300 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 357
           + G+ H++ + +  +  S G    G+LG   GA+   +P  I  L    V  V+CG    
Sbjct: 29  ASGERHSLLLLTNHRVLSCGDNSRGQLGR-RGAQRGELPEPIQALETLIVDLVSCGKEHS 87

Query: 358 YAVTKDGRVFAWGMGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416
            AV   GRVFAWG G+  QLG G+  E +++P ++M   L +  ++ VS G  H++ L K
Sbjct: 88  LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM--TLNDIKIIQVSCGHYHSLALSK 145

Query: 417 DKE 419
           D +
Sbjct: 146 DSQ 148



 Score = 36.2 bits (82), Expect = 0.057
 Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVC-LS 83
           +H +  T+ G V T G    GQLG      E++ P LV   + +V Q + G  HT+  + 
Sbjct: 246 AHTAVLTQDGKVFTFGDNRSGQLGYSP-TPEKRGPQLVERIDGLVSQIDCGSYHTLAYVH 304

Query: 84  KSGQVYSFG 92
            +GQV SFG
Sbjct: 305 TTGQVVSFG 313


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)

Query: 41  GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98
           G    GQLGLG  E+V+  ++      P  V +   GG H+  ++  G ++  G N +G 
Sbjct: 21  GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80

Query: 99  LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158
           LG   + +     P K      + QV+ G   T  LT++G+V   GS  ++ G +G+   
Sbjct: 81  LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138

Query: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211
            ++ +VP  ++L    VV +A+G  H V  TA G ++  G     CG +   G+   LF 
Sbjct: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198

Query: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
            A    R  GLE      CV+                 G+  + +++  G VY +G + +
Sbjct: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241

Query: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323
            QL     E+ F  +PQ + +  F+N   T  W G++    H V     GK ++ GRA+Y
Sbjct: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294

Query: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366
           G+LG                 L       S+P+    L   + V+CG+    A+   G  
Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353

Query: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
           ++WG   +   G G + + W+P  +  + L +   L V  G  H++ L
Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%)

Query: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85
           H +  T+ G +   G    GQLGLG    +    P        + Q   G   T+ L+++
Sbjct: 60  HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119

Query: 86  GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144
           GQV S G N  G LG         +VP  +EL +EKVV ++AG  H  A T  G VF WG
Sbjct: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178

Query: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198
           +   + G     G   P+    K    V    +   + V +G+DH   LT  G++Y  G 
Sbjct: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238

Query: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258
            + GQL       AN      + + +   C          + +    + G     A +  
Sbjct: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283

Query: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304
           G ++ +G ++Y QLG             +  F+     P ++ S  +        S G  
Sbjct: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343

Query: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
           H + +   G  YS G  E+G  G G  A   + P  +  L + S +  G   G+++
Sbjct: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)

Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
           ++ +G ++Y QLG    E   +PQ L  F    +S    +GG  H+  +   G  +  G 
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75

Query: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379
            + G+LGLG   +        S     +  VACG      +T++G+V + G  +  QLG 
Sbjct: 76  NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135

Query: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
                    V     +L    V+ +++G +H V
Sbjct: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68
           +H    TE G + T G+ D GQLG      E              R   ++ S P     
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334

Query: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128
             +   G  H + +   G  YS+G N+ G  G  T        P +  L    + V  G 
Sbjct: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393

Query: 129 SHTAAL 134
            H+ AL
Sbjct: 394 GHSLAL 399



 Score = 32.3 bits (72), Expect = 0.83
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)

Query: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
           S   A      +FAWG  +  QLG G  ED   P + +    + R V  ++ GG H+ ++
Sbjct: 6   SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)

Query: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169
           P ++    K        S    +TD+  VF++G    N    G     + ++VP +++  
Sbjct: 15  PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71

Query: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
               +  +   SG  H+++ T DG +Y  G     QLG       N    QG+  + V  
Sbjct: 72  CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123

Query: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
            +++K        +  +  CG++ + A++ +G V+ +G +N  Q+G+  T +   P+ +T
Sbjct: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175

Query: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347
           +  +  K  VG + GQ  ++ +   G+ Y  G    G+LGLG    + + P  ++ L +V
Sbjct: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233

Query: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405
             + + CG +   A+T +G ++AWG  T  QLGTG   +  SP  +M +  + RVV   +
Sbjct: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291

Query: 406 SGGQHT 411
               HT
Sbjct: 292 CHSAHT 297



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%)

Query: 1   MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
           +SP+ IA  R         S+ + V      T+   V   G      LG G+N       
Sbjct: 13  LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66

Query: 61  ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
            L  +    +++ +   G H +  ++ G VY++G N    LG  T+ +G   V     L 
Sbjct: 67  KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126

Query: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174
            ++VV+V+ G  H+ AL  DG VF WG   +N G +G      +   P +V   L +  V
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183

Query: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234
           V +A G    + +  +G++Y  G    GQLG       N G +      L P  V     
Sbjct: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227

Query: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286
            +   V      CG   T A++ EG +Y +G + Y QLGT    +   P ++
Sbjct: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93
           G V   G    GQLGLG N  +     + ++    V Q   G  HT+ L+  G +Y++G 
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259

Query: 94  NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150
           N  G LG  T  + + + P  + ++ E+VV+++A  S HT AA T  G V++WG  R  +
Sbjct: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317

Query: 151 GVI 153
            ++
Sbjct: 318 VIL 320


>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 60  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159

Query: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217

Query: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277

Query: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322

Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378

Query: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438

Query: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
            V M G+ ++      V+ G  H V L K
Sbjct: 439 RVTMPGEPVD------VACGVDHMVTLAK 461


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)

Query: 37  VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
           +  LG    G LGLG+  + +E ++   ++  +    +   G H V  +  G+V+++G N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 95  DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
               LG  T+  G  +VP  +      ++V++V+ G  H+  LT DG VF WG   +N+G
Sbjct: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182

Query: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
            +G    + +  +P +V     +  VV +A G    + +   G++Y  G    GQLG   
Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238

Query: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268
               N G +          C +   +G    +R Q   CG   T  ++ EG VY +G ++
Sbjct: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285

Query: 269 YHQLGTPGTESCFIPQNLTSFKN 291
           Y QLGT    +   P  +T  K+
Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKD 308



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)

Query: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242
           H+V+ T +G+++T G     QLG       N G        LVP C +  +  ++  +  
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155

Query: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302
            +  CG+Y +  ++ +G V+ +G +N  Q+G+  T +  IP+ +T    + K  V  + G
Sbjct: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213

Query: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360
           Q   + +   G+ Y  G    G+LGLG    + + P  ++ L    V  VACG +    +
Sbjct: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272

Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411
           T +G+V+AWG  +  QLGTG   +   P  +  +  ++R++   +    HT
Sbjct: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)

Query: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329
           LG    +S   P+ L S      + + +  G H  V   +EG+ ++ G   Y +LG G  
Sbjct: 78  LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136

Query: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
             G     I T +S    +  VACG+     +T DG VFAWG   + Q+G+G   +   P
Sbjct: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195

Query: 389 VEMMGKQLENRVVLSVSSG 407
             + G  L+N+VV++++ G
Sbjct: 196 RRVTG-CLQNKVVVTIACG 213



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)

Query: 33  EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90
           + G V   G    GQLGLG N   +  P  V+  + + VQ  A G  HT+ L+  GQVY+
Sbjct: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280

Query: 91  FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148
           +G N  G LG       S   P  VE ++++++++A  S HT AA T  G V++WG  R 
Sbjct: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339

Query: 149 NNGVI 153
            + ++
Sbjct: 340 QSVIL 344


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 89/379 (23%), Positives = 156/379 (41%), Gaps = 58/379 (15%)

Query: 68  DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK------- 120
           +VVQ  AG      +++SG++  +     GA        G  ++PG VE  +        
Sbjct: 333 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-------GGGSLLPGAVEQPQPQFISRFL 385

Query: 121 -------VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEPMKKSMVPVQVQLD 171
                  +  V+ GD  TA LTD G +  +GS   +NG +G   L  + +  + V+  L 
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGS--GSNGCLGHGSLTDISQPTI-VEALLG 442

Query: 172 VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVML 231
             +V+VA G  H++ L+ + +L+  G G+ G+LG        R      +++ +P     
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLG-----LGTRESHSCPQQVPMPP---- 493

Query: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG------------TES 279
              G       Q   CG   +  ++  G     G + +++LG                E 
Sbjct: 494 ---GQEA----QRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEE 546

Query: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
                 L S     +  +    G  H+  + + G  Y+ G  ++G+LG       ++ P 
Sbjct: 547 ALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PC 605

Query: 340 LISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 397
            +  L  +  + VACG +   A+  +  V++WG G   +LG  +DEDA  P  +   +  
Sbjct: 606 KVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETH 664

Query: 398 NRVVLSVSSGGQHTVLLVK 416
              V SVS    +T+L V+
Sbjct: 665 PYTVTSVSCCHGNTLLAVR 683



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 71/259 (27%), Positives = 110/259 (42%), Gaps = 36/259 (13%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVCLSKSGQVY 89
           T+ G+++T G G  G LG G ++ +  +P +V   +  ++VQ   G  H + LS   +++
Sbjct: 407 TDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELF 465

Query: 90  SFGCNDEGALGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTDDGRVFLWGSFR 147
           ++G  D G LG  T    S   P +V +   ++  +V  G   +  LT  G+    GS R
Sbjct: 466 AWGRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNR 523

Query: 148 DNNGVIGLL----EPMKKSMVPVQVQLDV---------PVVKVASGNDHLVMLTADGDLY 194
            N   +  L    EP+    V   +   +         P++ +  G  H   +TA GD Y
Sbjct: 524 FNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCY 583

Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 254
           T G  + GQLG        RG R              K +G  G ++     CG  FT A
Sbjct: 584 TFGSNQHGQLG----TNTRRGSR-----------APCKVQGLEG-IKMAMVACGDAFTVA 627

Query: 255 ISHEGHVYGFGLSNYHQLG 273
           I  E  VY +G     +LG
Sbjct: 628 IGAESEVYSWGKGARGRLG 646



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 81/324 (25%), Positives = 130/324 (40%), Gaps = 41/324 (12%)

Query: 117 LQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP------VQVQL 170
           L  +VVQV+AG +  A +T  GR+ LW +     G   LL    +   P      ++ Q 
Sbjct: 330 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS 389

Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230
            V +  VA G+     LT  G + T G G  G LG         G    + +  + + ++
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLG--------HGSLTDISQPTIVEALL 441

Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290
                  G+   Q A CGA    A+S E  ++ +G  +  +LG    ES   PQ +    
Sbjct: 442 -------GYEMVQVA-CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPP 493

Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-----------EGAEEKSIPT 339
                 V    G   ++ +   G+A + G   + +LGL            +  EE    T
Sbjct: 494 GQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551

Query: 340 LISRLP----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 395
           L+   P     + S+  G +   AVT  G  + +G   + QLGT     + +P ++ G  
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-- 609

Query: 396 LENRVVLSVSSGGQHTVLLVKDKE 419
           LE   +  V+ G   TV +  + E
Sbjct: 610 LEGIKMAMVACGDAFTVAIGAESE 633



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 7/112 (6%)

Query: 11  SPPADAIPK-SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV 69
           S P D  P  S  +  +H +  T  G   T G    GQLG       R  P  V   E +
Sbjct: 555 SAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PCKVQGLEGI 613

Query: 70  VQA--EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 119
             A    G   TV +    +VYS+G    G LGR     G   +P  V+L E
Sbjct: 614 KMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAG---LPRPVQLDE 662


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 78/313 (24%), Positives = 128/313 (40%), Gaps = 41/313 (13%)

Query: 120 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVAS 179
           K+  V  G  H   L+ DG+ F + ++              K +    +  +  ++++  
Sbjct: 98  KIHSVDQGAEHMLILSSDGKPFEYDNYS------------MKHLRFESILQEKKIIQITC 145

Query: 180 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH 239
           G+ H + L+  G+L+  G    GQLG V   F +    Q +E L                
Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL--------------AG 190

Query: 240 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF 299
           V       G   + A+S  G++Y +G +   QLG   TES   P  +    N    +V  
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC 250

Query: 300 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 357
            G   H+  +  +G  ++ G  ++G+LG      E   P L++ L    V+ +ACG    
Sbjct: 251 GGS--HSALLTQDGLLFTFGAGKHGQLGHNSTQNELR-PCLVAELVGYRVTQIACGRWHT 307

Query: 358 YAVTKD-GRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSS--------GG 408
            A   D G+VF++G G + QLG G   D   P+ +     E   + S +S        GG
Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367

Query: 409 QHTVLLVKDKEQS 421
             ++LL   KE S
Sbjct: 368 NQSILLWIKKENS 380



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 73/326 (22%), Positives = 144/326 (44%), Gaps = 42/326 (12%)

Query: 21  KKVKVSHRSHSTEPGLVLTLGQGDVG----QLGLGENVMERKKPALVSIPEDVVQAEAGG 76
           ++V+V+ R     PG +  L +G  G    QL  G       K   +     +   + G 
Sbjct: 48  RRVEVT-RQLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGA 106

Query: 77  MHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTD 136
            H + LS  G+ + +       L  ++ ++           ++K++Q++ GD H+ AL+ 
Sbjct: 107 EHMLILSSDGKPFEYDNYSMKHLRFESILQ-----------EKKIIQITCGDYHSLALSK 155

Query: 137 DGRVFLWGSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLY 194
            G +F WG  ++ +G +G+      +  P  V+    VP+ ++++G  H + L+  G++Y
Sbjct: 156 GGELFAWG--QNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIY 213

Query: 195 TLGCGEQGQLG-RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTF 253
           + G  E GQLG    E   +    +GL+                 + + +   CG   + 
Sbjct: 214 SWGKNECGQLGLGHTESKDDPSLIEGLD-----------------NQKVEFVACGGSHSA 256

Query: 254 AISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE- 312
            ++ +G ++ FG   + QLG   T++   P  +        + +  + G+ HT+   S+ 
Sbjct: 257 LLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGRWHTLAYVSDL 314

Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIP 338
           GK +S G  + G+LG G G  ++ +P
Sbjct: 315 GKVFSFGSGKDGQLGNG-GTRDQLMP 339



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 8/110 (7%)

Query: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVC-L 82
           SH +  T+ GL+ T G G  GQLG   +     +P LV+  +   V Q   G  HT+  +
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311

Query: 83  SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
           S  G+V+SFG   +G LG   + +    +P KV   E++      +SHT+
Sbjct: 312 SDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKL----ESHTS 357


>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)

Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230
           D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G           
Sbjct: 32  DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80

Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290
               G    V             A+S +G ++G+G S Y QL +    +         F 
Sbjct: 81  ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136

Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 345
              K      GG    V ++ EG  +  G   YG LG G    E ++P +I         
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192

Query: 346 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 398
                 VS + CG S   A+T  G +F WG      LG G+ ED + P  V M G+ ++ 
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251

Query: 399 RVVLSVSSGGQHTVLLVK 416
                V+ G  H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)

Query: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164

Query: 267 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318
             Y  LG  P      +P+        LT F N          G      + ++G+ +  
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221

Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 353
           G+   G LG+G   E++  P  ++       VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94

Query: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144

Query: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194

Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244


>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)

Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230
           D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G           
Sbjct: 32  DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80

Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 290
               G    V             A+S +G ++G+G S Y QL +    +         F 
Sbjct: 81  ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136

Query: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 345
              K      GG    V ++ EG  +  G   YG LG G    E ++P +I         
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192

Query: 346 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 398
                 VS + CG S   A+T  G +F WG      LG G+ ED + P  V M G+ ++ 
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251

Query: 399 RVVLSVSSGGQHTVLLVK 416
                V+ G  H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)

Query: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164

Query: 267 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318
             Y  LG  P      +P+        LT F N          G      + ++G+ +  
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221

Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 353
           G+   G LG+G   E++  P  ++       VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94

Query: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144

Query: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194

Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244


>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235

Query: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274

Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71

Query: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130

Query: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178

Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236

Query: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295

Query: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355

Query: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
              V +V+ G  +T +   +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235

Query: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274

Query: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71

Query: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130

Query: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178

Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236

Query: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295

Query: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355

Query: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
              V +V+ G  +T +   +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 5/155 (3%)

Query: 259 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318
           G V+ +G  ++ +LG  G+E C IPQN+          +    G    + +   G  ++ 
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 782

Query: 319 GRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQL 377
           G+ +Y RLG       + +  +   R   +  VA GA    AV   G+V+AWG   + Q 
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842

Query: 378 GTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
           G G       P+ + G  LE + ++ V+ G  H+V
Sbjct: 843 GNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 875



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 2/155 (1%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 93
           GLV + G GD G+LG G +        +  +  + V Q E G    + L+KSG V+++G 
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784

Query: 94  NDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVI 153
            D   LG  + V   ++   +    +K+V V+ G  H  A+ D G+V+ WG         
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844

Query: 154 GLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
           G     +K M+ VQ      ++ VA G+ H V  T
Sbjct: 845 GTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 878



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
           T+ G+V T G+GD  +LG   +V  RK   +  +  + +V    G  H + +  SGQVY+
Sbjct: 774 TKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 833

Query: 91  FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
           +G ND G  G   T+V    M+   +E Q K++ V+ G SH+ A T
Sbjct: 834 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 878



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 39/110 (35%), Positives = 55/110 (50%), Gaps = 6/110 (5%)

Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 370
           G  +S G  ++G+LG G G+E  +IP  I RL    V  + CGA    A+TK G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 783

Query: 371 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
            G  ++LG   D        + G  L  + ++ V+ G QH  L V D  Q
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 830



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 24/186 (12%)

Query: 181 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
           +D+  +LT     G +++ G G+ G+LGR        GG +G     +P+ +  +    +
Sbjct: 712 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 758

Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 297
           G  + +   CGA F  A++  G V+ +G  +Y +LG          Q +   +      V
Sbjct: 759 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHV 815

Query: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
              G QH    MDS G+ Y+ G  ++G+ G G     +  P L+  L    +  VACG+S
Sbjct: 816 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 872

Query: 356 VGYAVT 361
              A T
Sbjct: 873 HSVAWT 878


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)

Query: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316
           +E  V+ +G  ++ +LG  G+E C IPQN+          +    G    + +   G  +
Sbjct: 21  YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78

Query: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374
           + G+ +Y RLG       +  P ++  L    +  VA GA    AV   G+V+AWG   +
Sbjct: 79  TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137

Query: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
            Q G G       P  + G  LE + ++ V+ G  H+V
Sbjct: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)

Query: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369
           E   +S G  ++G+LG G G+E  +IP  I RL    V  + CGA    A+TK G V+ W
Sbjct: 22  ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80

Query: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
           G G  ++LG   D     P  + G  L  + ++ V+ G QH  L V D  Q
Sbjct: 81  GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)

Query: 36  LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
           LV + G GD G+LG G +        +  +  + V Q E G    + L+KSG V+++G  
Sbjct: 24  LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83

Query: 95  DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
           D   LG   D  V   ++V G     +K+V V+ G  H  A+ D G+V+ WG        
Sbjct: 84  DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141

Query: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
            G     +K  + VQ      ++ VA G+ H V  T
Sbjct: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
           T+ G+V T G+GD  +LG   +V  RK   +  +  + +V    G  H + +  SGQVY+
Sbjct: 72  TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131

Query: 91  FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
           +G ND G  G  T+    +    +    +K++ V+ G SH+ A T
Sbjct: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)

Query: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233
           ++   SG + LV    DGD   LG                RGG +G     +P+ +  + 
Sbjct: 14  ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52

Query: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293
              +G  + +   CGA F  A++  G V+ +G  +Y +LG         PQ +   +   
Sbjct: 53  LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109

Query: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351
              V   G QH    MDS G+ Y+ G  ++G+ G G     +  PTL+  L    +  VA
Sbjct: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166

Query: 352 CGASVGYAVT 361
           CG+S   A T
Sbjct: 167 CGSSHSVAWT 176


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1052

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 7/156 (4%)

Query: 259 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318
           G V+ +G  ++ +LG  G+E C IPQN+          +    G    + +   G  ++ 
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 732

Query: 319 GRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQ 376
           G+ +Y RLG       +  P ++  L    +  VA GA    AV   G+V+AWG   + Q
Sbjct: 733 GKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791

Query: 377 LGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
            G G       P+ + G  LE + ++ V+ G  H+V
Sbjct: 792 QGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 825



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 49/157 (31%), Positives = 73/157 (46%), Gaps = 6/157 (3%)

Query: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 93
           GLV + G GD G+LG G +        +  +  + V Q E G    + L+KSG V+++G 
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734

Query: 94  NDEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
            D   LG   D  V   ++V G     +K+V V+ G  H  A+ D G+V+ WG       
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792

Query: 152 VIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
             G     +K M+ VQ      ++ VA G+ H V  T
Sbjct: 793 GNGTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 828



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 40/110 (36%), Positives = 56/110 (50%), Gaps = 6/110 (5%)

Query: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 370
           G  +S G  ++G+LG G G+E  +IP  I RL    V  + CGA    A+TK G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 733

Query: 371 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
            G  ++LG   D     P  + G  L  + ++ V+ G QH  L V D  Q
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 780



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%)

Query: 32  TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
           T+ G+V T G+GD  +LG   +V  RK   +  +  + +V    G  H + +  SGQVY+
Sbjct: 724 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 783

Query: 91  FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
           +G ND G  G   T+V    M+   +E Q K++ V+ G SH+ A T
Sbjct: 784 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 828



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 51/186 (27%), Positives = 84/186 (45%), Gaps = 24/186 (12%)

Query: 181 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
           +D+  +LT     G +++ G G+ G+LGR        GG +G     +P+ +  +    +
Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 708

Query: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 297
           G  + +   CGA F  A++  G V+ +G  +Y +LG         PQ +   +      V
Sbjct: 709 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHV 765

Query: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
              G QH    MDS G+ Y+ G  ++G+ G G     +  P L+  L    +  VACG+S
Sbjct: 766 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 822

Query: 356 VGYAVT 361
              A T
Sbjct: 823 HSVAWT 828


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,054,567
Number of Sequences: 37866
Number of extensions: 784303
Number of successful extensions: 2631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1678
Number of HSP's gapped (non-prelim): 273
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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