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Search of human proteins with 114796646
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114796646 regulator of chromosome condensation 1 isoform b
[Homo sapiens]
(438 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 884 0.0
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 874 0.0
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 840 0.0
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 840 0.0
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 840 0.0
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 840 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 142 6e-34
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 142 6e-34
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 140 2e-33
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 140 2e-33
gi|7657152 hect domain and RLD 3 [Homo sapiens] 132 6e-31
gi|126032348 hect domain and RLD 2 [Homo sapiens] 124 2e-28
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 109 4e-24
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 100 3e-21
gi|61563742 hect domain and RLD 6 [Homo sapiens] 98 2e-20
gi|6912330 deafness locus associated putative guanine nucleotide... 97 4e-20
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 89 6e-18
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 87 2e-17
gi|4557445 regulator of chromosome condensation and BTB domain c... 83 4e-16
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 81 2e-15
gi|110825982 hect domain and RLD 5 [Homo sapiens] 80 4e-15
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 69 1e-11
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 69 1e-11
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 3e-09
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 60 4e-09
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 4e-09
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 884 bits (2283), Expect = 0.0
Identities = 438/438 (100%), Positives = 438/438 (100%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
Query: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
Query: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
Query: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
Query: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
Query: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
Query: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
Query: 421 VSSGGQHTVLLVKDKEQS 438
VSSGGQHTVLLVKDKEQS
Sbjct: 421 VSSGGQHTVLLVKDKEQS 438
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 874 bits (2258), Expect = 0.0
Identities = 438/452 (96%), Positives = 438/452 (96%), Gaps = 14/452 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQ--------------VSHRS 46
MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQ VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
Query: 47 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 106
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
Query: 107 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
Query: 167 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 226
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
Query: 227 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
Query: 287 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 346
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
Query: 347 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
Query: 407 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 438
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 840 bits (2169), Expect = 0.0
Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRSHSTEPGLVLTLGQG
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43
Query: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 44 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103
Query: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163
Query: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223
Query: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283
Query: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343
Query: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 421 VSSGGQHTVLLVKDKEQS 438
VSSGGQHTVLLVKDKEQS
Sbjct: 404 VSSGGQHTVLLVKDKEQS 421
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 840 bits (2169), Expect = 0.0
Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRSHSTEPGLVLTLGQG
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43
Query: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 44 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103
Query: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163
Query: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223
Query: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283
Query: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343
Query: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 421 VSSGGQHTVLLVKDKEQS 438
VSSGGQHTVLLVKDKEQS
Sbjct: 404 VSSGGQHTVLLVKDKEQS 421
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 840 bits (2169), Expect = 0.0
Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRSHSTEPGLVLTLGQG
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43
Query: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 44 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103
Query: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163
Query: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223
Query: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283
Query: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343
Query: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 421 VSSGGQHTVLLVKDKEQS 438
VSSGGQHTVLLVKDKEQS
Sbjct: 404 VSSGGQHTVLLVKDKEQS 421
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 840 bits (2169), Expect = 0.0
Identities = 421/438 (96%), Positives = 421/438 (96%), Gaps = 17/438 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRSHSTEPGLVLTLGQG
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG 43
Query: 61 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 120
DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT
Sbjct: 44 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 103
Query: 121 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 180
SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM
Sbjct: 104 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 163
Query: 181 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 240
VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL
Sbjct: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223
Query: 241 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 300
LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP
Sbjct: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283
Query: 301 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 360
QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343
Query: 361 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS
Sbjct: 344 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 421 VSSGGQHTVLLVKDKEQS 438
VSSGGQHTVLLVKDKEQS
Sbjct: 404 VSSGGQHTVLLVKDKEQS 421
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 142 bits (358), Expect = 6e-34
Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)
Query: 54 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 109
+L G GQLGLG E V+E +K I + V G HTV + G VY+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 110 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 168
CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G
Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 169 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 226
+GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174
Query: 227 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
+ Q L+ LL + F G +F ++ G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 287 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 346
QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 347 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 403
+ E + P + L V+ +ACG A V GR++++G+G N QLGTG +
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 404 SPVEMMG 410
SP + G
Sbjct: 337 SPFTVKG 343
Score = 122 bits (307), Expect = 5e-28
Identities = 101/319 (31%), Positives = 148/319 (46%), Gaps = 27/319 (8%)
Query: 40 CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTV 97
C + H + G V T G D+GQLG + RKKP V +++V G HT+
Sbjct: 41 CGLRHTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTL 97
Query: 98 CLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGR 156
L+ GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+
Sbjct: 98 ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Query: 157 VFLWGSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLG 214
VF WG ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G
Sbjct: 158 VFCWG--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 215 CGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH 274
+ GQLG E VP +LKS S+ V CG T A++
Sbjct: 216 RNKFGQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTK 259
Query: 275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYS 334
EG V+ FG Y QLG T P+ + S + + G QH + + S G+ YS
Sbjct: 260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYS 318
Query: 335 LGRAEYGRLGLGEGAEEKS 353
G G+LG G + KS
Sbjct: 319 FGLGGNGQLGTGSTSNRKS 337
Score = 104 bits (259), Expect = 2e-22
Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)
Query: 172 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 231
+LEP K ++ V V G H V + DG +YT GC + GQLG
Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69
Query: 232 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 285
KSR V DA CG T A++ +G VY +GL +
Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 286 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 344
QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 345 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 402
LG ++++ P L+ L + VA G + + +T G +F WG QLG + D
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 403 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 434
+ P + K L ++ ++ + G HT L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 87.4 bits (215), Expect = 2e-17
Identities = 84/284 (29%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 19 KSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGL-GENVMERKKP 77
KS+K + A + A SC +H + G V G GQLGL G R
Sbjct: 70 KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPR 129
Query: 78 ALVSIPE-DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPG--KVEL 134
+ S+ + +VQ G H++ LSK+ +V+ +G N G LG T + + P K L
Sbjct: 130 NIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK-KQTSPQLLKSLL 188
Query: 135 QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL-DVPVVK 193
+QV+AG +H+ LT G +F WG R+ G +GL + + + + L +V
Sbjct: 189 GIPFMQVAAGGAHSFVLTLSGAIFGWG--RNKFGQLGLNDENDRYVPNLLKSLRSQKIVY 246
Query: 194 VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGS 253
+ G DH LT +G ++T G G GQL G + P+ V + GS
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQL-----------GHNSTSHEINPRKV-FELMGS 294
Query: 254 RGHVRFQDAFCGAYFTFA-ISHEGHVYGFGLSNYHQLGTPGTES 296
+ CG T A + G +Y FGL QLGT T +
Sbjct: 295 ----IVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 142 bits (358), Expect = 6e-34
Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)
Query: 54 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 109
+L G GQLGLG E V+E +K I + V G HTV + G VY+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 110 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 168
CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G
Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 169 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 226
+GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174
Query: 227 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
+ Q L+ LL + F G +F ++ G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 287 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 346
QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 347 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 403
+ E + P + L V+ +ACG A V GR++++G+G N QLGTG +
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 404 SPVEMMG 410
SP + G
Sbjct: 337 SPFTVKG 343
Score = 122 bits (307), Expect = 5e-28
Identities = 101/319 (31%), Positives = 148/319 (46%), Gaps = 27/319 (8%)
Query: 40 CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTV 97
C + H + G V T G D+GQLG + RKKP V +++V G HT+
Sbjct: 41 CGLRHTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTL 97
Query: 98 CLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGR 156
L+ GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+
Sbjct: 98 ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Query: 157 VFLWGSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLG 214
VF WG ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G
Sbjct: 158 VFCWG--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 215 CGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH 274
+ GQLG E VP +LKS S+ V CG T A++
Sbjct: 216 RNKFGQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTK 259
Query: 275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYS 334
EG V+ FG Y QLG T P+ + S + + G QH + + S G+ YS
Sbjct: 260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYS 318
Query: 335 LGRAEYGRLGLGEGAEEKS 353
G G+LG G + KS
Sbjct: 319 FGLGGNGQLGTGSTSNRKS 337
Score = 104 bits (259), Expect = 2e-22
Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)
Query: 172 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 231
+LEP K ++ V V G H V + DG +YT GC + GQLG
Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69
Query: 232 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 285
KSR V DA CG T A++ +G VY +GL +
Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 286 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 344
QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 345 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 402
LG ++++ P L+ L + VA G + + +T G +F WG QLG + D
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 403 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 434
+ P + K L ++ ++ + G HT L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 87.4 bits (215), Expect = 2e-17
Identities = 84/284 (29%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 19 KSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGL-GENVMERKKP 77
KS+K + A + A SC +H + G V G GQLGL G R
Sbjct: 70 KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPR 129
Query: 78 ALVSIPE-DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPG--KVEL 134
+ S+ + +VQ G H++ LSK+ +V+ +G N G LG T + + P K L
Sbjct: 130 NIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK-KQTSPQLLKSLL 188
Query: 135 QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL-DVPVVK 193
+QV+AG +H+ LT G +F WG R+ G +GL + + + + L +V
Sbjct: 189 GIPFMQVAAGGAHSFVLTLSGAIFGWG--RNKFGQLGLNDENDRYVPNLLKSLRSQKIVY 246
Query: 194 VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGS 253
+ G DH LT +G ++T G G GQL G + P+ V + GS
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQL-----------GHNSTSHEINPRKV-FELMGS 294
Query: 254 RGHVRFQDAFCGAYFTFA-ISHEGHVYGFGLSNYHQLGTPGTES 296
+ CG T A + G +Y FGL QLGT T +
Sbjct: 295 ----IVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 140 bits (354), Expect = 2e-33
Identities = 115/344 (33%), Positives = 166/344 (48%), Gaps = 29/344 (8%)
Query: 34 VPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAG 92
VP SC H + T + G + GQLGLG K + ++ PE V A G
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 93 GMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAAL 151
HT+ ++ G VY+ G N+EG LG DT + V + K+ Q+SAG + +AAL
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 211
T+DGR+F+WG ++ G IGL + + VP QV + PV ++ G H +T DG+LY
Sbjct: 156 TEDGRLFMWGD--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
Query: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
G E G+LG +L N Q + +P+ V+ CG T
Sbjct: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVV 257
Query: 272 ISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 329
++ E VY FGL + QLG GT P+ + + ++ T S++ S G++HT +
Sbjct: 258 LT-ENAVYTFGLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDI 313
Query: 330 GKAYSLGRAEYGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 370
G Y+ G +G+LGLG E IPTL S V VACG
Sbjct: 314 GLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
Score = 95.9 bits (237), Expect = 6e-20
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 68 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 126
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
Query: 127 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQ-- 184
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
Query: 185 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
+ + ++++G++ LT DG L+ G +GQ+G + + + VP+
Sbjct: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQ 184
Query: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQN 302
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
Query: 303 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 361
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
Query: 362 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
Query: 421 VSSGGQHTVL 430
V+ GG H V+
Sbjct: 354 VACGGCHMVV 363
Score = 75.9 bits (185), Expect = 7e-14
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 151 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 208
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
Query: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 267
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
Query: 268 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
Query: 326 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 385
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 386 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 434
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
Score = 61.2 bits (147), Expect = 2e-09
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 323
CG + ++ +Y FG +N+ QLG + P + + K G++HT
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC--GRNHT 99
Query: 324 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA---VSSVACGASVGYAVTKD 380
+ G Y+ G G+LGLG+ EE++ +IS + + ++ G++ A+T+D
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
Query: 381 GRVFAWGMGTNYQLGTGQDEDAWSPVEM-MGKQLENRVVLSVSSGGQHTVLLVKDKE 436
GR+F WG + Q+G + P ++ +GK V +S G H+ + D E
Sbjct: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-----VSWISCGYYHSAFVTTDGE 210
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 140 bits (354), Expect = 2e-33
Identities = 115/344 (33%), Positives = 166/344 (48%), Gaps = 29/344 (8%)
Query: 34 VPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAG 92
VP SC H + T + G + GQLGLG K + ++ PE V A G
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 93 GMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAAL 151
HT+ ++ G VY+ G N+EG LG DT + V + K+ Q+SAG + +AAL
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 211
T+DGR+F+WG ++ G IGL + + VP QV + PV ++ G H +T DG+LY
Sbjct: 156 TEDGRLFMWGD--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
Query: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
G E G+LG +L N Q + +P+ V+ CG T
Sbjct: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVV 257
Query: 272 ISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 329
++ E VY FGL + QLG GT P+ + + ++ T S++ S G++HT +
Sbjct: 258 LT-ENAVYTFGLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDI 313
Query: 330 GKAYSLGRAEYGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 370
G Y+ G +G+LGLG E IPTL S V VACG
Sbjct: 314 GLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
Score = 95.9 bits (237), Expect = 6e-20
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 68 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 126
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
Query: 127 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQ-- 184
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
Query: 185 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
+ + ++++G++ LT DG L+ G +GQ+G + + + VP+
Sbjct: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQ 184
Query: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQN 302
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
Query: 303 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 361
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
Query: 362 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
Query: 421 VSSGGQHTVL 430
V+ GG H V+
Sbjct: 354 VACGGCHMVV 363
Score = 75.9 bits (185), Expect = 7e-14
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 151 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 208
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
Query: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 267
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
Query: 268 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
Query: 326 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 385
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 386 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 434
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
Score = 61.2 bits (147), Expect = 2e-09
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 323
CG + ++ +Y FG +N+ QLG + P + + K G++HT
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC--GRNHT 99
Query: 324 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA---VSSVACGASVGYAVTKD 380
+ G Y+ G G+LGLG+ EE++ +IS + + ++ G++ A+T+D
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
Query: 381 GRVFAWGMGTNYQLGTGQDEDAWSPVEM-MGKQLENRVVLSVSSGGQHTVLLVKDKE 436
GR+F WG + Q+G + P ++ +GK V +S G H+ + D E
Sbjct: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-----VSWISCGYYHSAFVTTDGE 210
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 132 bits (332), Expect = 6e-31
Identities = 113/404 (27%), Positives = 184/404 (45%), Gaps = 43/404 (10%)
Query: 54 VLTLGQGDVGQLGLGEN----VMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 109
+L G +GQ G+ N V E + +S V + GG H+V L + G+VY+ G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFIS-DRSVKEVACGGNHSVFLLEDGEVYTCG 59
Query: 110 CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 169
N +G LG + E + + + ++ V+ G+SH+ AL+D G++F WG+ D G
Sbjct: 60 LNTKGQLGHEREGNKPEQIGALAD--QHIIHVACGESHSLALSDRGQLFSWGAGSD--GQ 115
Query: 170 IGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPEL 227
+GL+ VP +Q +++V+ GN H + L ADG +T G GQLG E
Sbjct: 116 LGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE- 174
Query: 228 FANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYH 287
F ++ Q + R G Q A GA+ +FA+S G V+G+G++N
Sbjct: 175 FPSQASPQ-------------RVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWGMNNAG 220
Query: 288 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 347
QLG + P ++ + T+ V S G+ HT + G ++ G G+LG
Sbjct: 221 QLGLSDEKDRESPCHVKLLR--TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278
Query: 348 GAEEKSIPTLISRLPA-VSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSP 405
+E + ++ + + V+ +ACG A V G ++A+G G QLGTG + P
Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338
Query: 406 VEMMG-------------KQLENRVVLSVSSGGQHTVLLVKDKE 436
+ G + + +V + SGG T +L E
Sbjct: 339 SPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYE 382
Score = 108 bits (269), Expect = 1e-23
Identities = 90/320 (28%), Positives = 140/320 (43%), Gaps = 29/320 (9%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHT 96
+C +H E G V T G GQLG + E KP + D ++ G H+
Sbjct: 40 ACGGNHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGALADQHIIHVACGESHS 96
Query: 97 VCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDD 154
+ LS GQ++S+G +G LG T+ E S VP ++ Q+ ++QVS G+ H AL D
Sbjct: 97 LALSDRGQLFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 155
Query: 155 GRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYT 212
G+ F WG ++++G +GL + P +V+ +P+ +VA+G H L+ G ++
Sbjct: 156 GQFFTWG--KNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFG 213
Query: 213 LGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAI 272
G GQLG E +R ++ L K V + CG T +
Sbjct: 214 WGMNNAGQLGLSDE--KDRESPCHVKLLRTQKVVYIS--------------CGEEHTAVL 257
Query: 273 SHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKA 332
+ G V+ FG + QLG P+ + S + + G QH + S G
Sbjct: 258 TKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA-CGRQHTLAFVPSSGLI 316
Query: 333 YSLGRAEYGRLGLGEGAEEK 352
Y+ G G+LG G K
Sbjct: 317 YAFGCGARGQLGTGHTCNVK 336
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 124 bits (311), Expect = 2e-28
Identities = 93/303 (30%), Positives = 144/303 (47%), Gaps = 30/303 (9%)
Query: 138 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 197
V Q++ + L+ +GRV+ D L P VQ +VK+A+
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDT------LAPQL-----VQGLASRNIVKIAAH 501
Query: 198 ND--HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 255
+D H + L A G++Y+ GCG+ G+LG G LE PK + S G +
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH--------GDTVPLEE---PKVISAFS-GKQA 549
Query: 256 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 315
CG+ ++ AI+ EG +Y +G NY +LG +E IP + K V
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
Query: 316 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASV 373
G T+ + G+ +S G +YG+LG G G++ P LI +L V V CG+
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRG-GSDGCKTPKLIEKLQDLDVVKVRCGSQF 668
Query: 374 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 433
A+TKDG+V++WG G N +LG G +E P + G L+ + V+ V++G H + L +
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--LQGKKVIDVAAGSTHCLALTE 726
Query: 434 DKE 436
D E
Sbjct: 727 DSE 729
Score = 122 bits (307), Expect = 5e-28
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 28/347 (8%)
Query: 96 TVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM---VPGKVELQEKVVQVSAGDSHTAALT 152
T+ SG +Y +G N G LG +EG+++ P + + VQ+ G+ A+T
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
Query: 153 DDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-LDVPVVKVASGNDHLVMLTADGDLY 211
DG+++ G IG E + + +Q + + V V SG H + L+++G++Y
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
Query: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
+ G E G+LG G R +R P+ + RG + D G +
Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDR---PRVI----ESLRG-IEVVDVAAGGAHSAC 4105
Query: 272 ISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK 331
++ G +Y +G Y +LG +E P+ + + + + G T+C+ +
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 332 AYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMG 389
+S G +YG+LG G G++ +P I L V V CG+ A+TK G V+ WG G
Sbjct: 4166 VWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224
Query: 390 TNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 436
++LG G D+ P ++ G L+ + V+++++G H V +D E
Sbjct: 4225 DYHRLGHGSDDHVRRPRQVQG--LQGKKVIAIATGSLHCVCCTEDGE 4269
Score = 120 bits (302), Expect = 2e-27
Identities = 104/364 (28%), Positives = 170/364 (46%), Gaps = 41/364 (11%)
Query: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM-VPGKVELQE--KVVQVS 142
+++ +A G+ + ++ +V+ +G ND+ LG ++GS++ VP E VVQV+
Sbjct: 2943 LIRKKAAGLESAATIRT-KVFVWGLNDKDQLG---GLKGSKIKVPSFSETLSALNVVQVA 2998
Query: 143 AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD------VPVVKVAS 196
G A+T +G+V+ G NG +GL + VP+ Q+ V V V S
Sbjct: 2999 GGSKSLFAVTVEGKVYACGEA--TNGRLGL--GISSGTVPIPRQITALSSYVVKKVAVHS 3054
Query: 197 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCV-MLKSRGSRG 255
G H LT DG +++ G G+ G+LG + ++ P+ + LK++
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-----------PRLIEALKTK---- 3099
Query: 256 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 315
R +D CG+ + A++ G +Y +GL Y +LG + P+ + V
Sbjct: 3100 --RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVA 3157
Query: 316 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASV 373
T+ + EG +S G ++G+LG G G+E +IP I RL V + CGA
Sbjct: 3158 CGSRDAQTLALTDEGLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQF 3216
Query: 374 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 433
A+TK G V+ WG G ++LG G D P + G L + ++ V+ G H L V
Sbjct: 3217 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG--LRGKKIVHVAVGALH-CLAVT 3273
Query: 434 DKEQ 437
D Q
Sbjct: 3274 DSGQ 3277
Score = 120 bits (301), Expect = 2e-27
Identities = 115/387 (29%), Positives = 168/387 (43%), Gaps = 36/387 (9%)
Query: 54 VLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLSKSGQVYSFGCN 111
V G D QLG G + K P+ +VVQ G ++ G+VY+ G
Sbjct: 2961 VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019
Query: 112 DEGALGRDTSVEGSEMVPGKVELQE----KVVQVSAGDSHTAALTDDGRVFLWGSFRDNN 167
G LG S G+ +P ++ K V V +G H ALT DG+VF WG D
Sbjct: 3020 TNGRLGLGIS-SGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD-- 3076
Query: 168 GVIGLLEPMKKSMVPVQVQLDVPVVK-VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 226
G +G M + L ++ +A G+ H LT+ G+LYT G GE G+LG
Sbjct: 3077 GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN 3136
Query: 227 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF--TFAISHEGHVYGFGLS 284
L PK V + GH Q A CG+ T A++ EG V+ +G
Sbjct: 3137 TTQ-----------LKPKMVKVLL----GHRVIQVA-CGSRDAQTLALTDEGLVFSWGDG 3180
Query: 285 NYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 344
++ +LG G+E C IPQN+ + G ++ + G ++ G+ +Y RLG
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
Query: 345 LGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 402
G + P ++ L + VA GA AVT G+V+AWG + Q G G
Sbjct: 3239 HGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3297
Query: 403 WSPVEMMGKQLENRVVLSVSSGGQHTV 429
P + G LE + + V+ G H+V
Sbjct: 3298 RKPTLVQG--LEGQKITRVACGSSHSV 3322
Score = 114 bits (284), Expect = 2e-25
Identities = 110/398 (27%), Positives = 162/398 (40%), Gaps = 37/398 (9%)
Query: 52 GLVLTLGQGDVGQLGLGENVMER-KKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGC 110
G + G GQLG E + P VQ G ++ G++Y+ G
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011
Query: 111 NDEGALGRDTSVEGSEMVPGKVELQE------KVVQVSAGDSHTAALTDDGRVFLWGSFR 164
G LG + G+E V L+ K V V++G H AL+ +G V+ WG
Sbjct: 4012 GAGGRLG----IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
Query: 165 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRV 224
D G P + V ++ + VV VA+G H +TA GDLYT G G G+LG
Sbjct: 4068 DGKLGHGNRSPCDRPRV-IESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126
Query: 225 PELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA--YFTFAISHEGHVYGFG 282
E L PK V +GH R D CG+ T ++ + V+ +G
Sbjct: 4127 DS-----------EDQLKPKLV----EALQGH-RVVDIACGSGDAQTLCLTDDDTVWSWG 4170
Query: 283 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 342
+Y +LG G++ C +P + S V G +V + G Y+ G+ +Y R
Sbjct: 4171 DGDYGKLGRGGSDGCKVPMKIDSLTGL--GVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228
Query: 343 LGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE 400
LG G + P + L V ++A G+ T+DG V+ WG QLG G
Sbjct: 4229 LGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287
Query: 401 DAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 438
P + L+ + V V+ G HT+ K S
Sbjct: 4288 AIQRP--RLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323
Score = 108 bits (270), Expect = 1e-23
Identities = 95/332 (28%), Positives = 152/332 (45%), Gaps = 29/332 (8%)
Query: 49 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEA---GGMHTVCLSKSGQV 105
T G + G G G+LG+G L SI ++ A GG H + LS G+V
Sbjct: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060
Query: 106 YSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLWGSF 163
YS+G ++G LG P +E +VV V+AG +H+A +T G ++ WG
Sbjct: 4061 YSWGEAEDGKLGHGNRSPCDR--PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4118
Query: 164 RDNN-GVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222
R G + +K +V V + SG+ + LT D +++ G G+ G+LG
Sbjct: 4119 RYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4178
Query: 223 RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 282
RGG G + VP + + S G V+ + CG+ F+ A++ G VY +G
Sbjct: 4179 --------RGGSDGCK---VP--MKIDSLTGLGVVKVE---CGSQFSVALTKSGAVYTWG 4222
Query: 283 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 342
+YH+LG + P+ + + K + + G H VC +G+ Y+ G + G+
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQG--KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280
Query: 343 LGLGEGAEEKSIPTLISRLPA--VSSVACGAS 372
LG G P L++ L V+ VACG++
Sbjct: 4281 LGDGT-TNAIQRPRLVAALQGKKVNRVACGSA 4311
Score = 103 bits (257), Expect = 3e-22
Identities = 94/342 (27%), Positives = 157/342 (45%), Gaps = 36/342 (10%)
Query: 49 TEPGLVLTLGQGDVGQLGLGENV----MERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 104
T G V G+ G+LGLG + + R+ AL S V +GG H L+ G+
Sbjct: 3008 TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK 3067
Query: 105 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFR 164
V+S+G D+G LG + + + + +++ ++ G SH+AALT G ++ WG
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGL-- 3125
Query: 165 DNNGVIGLL------EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 218
G G L +K MV V + V V S + + LT +G +++ G G+
Sbjct: 3126 ---GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182
Query: 219 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 278
G+LG RGG +G +P+ ++ +G + + CGA F+ A++ G V
Sbjct: 3183 GKLG--------RGGSEGCN---IPQ--NIERLNGQGVCQIE---CGAQFSLALTKSGVV 3226
Query: 279 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 338
+ +G +Y +LG PQ + + K V + G H + + G+ Y+ G
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRG--KKIVHVAVGALHCLAVTDSGQVYAWGDN 3284
Query: 339 EYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVT 378
++G+ G G + PTL+ L ++ VACG+S A T
Sbjct: 3285 DHGQQGNGTTTVNRK-PTLVQGLEGQKITRVACGSSHSVAWT 3325
Score = 89.7 bits (221), Expect = 5e-18
Identities = 82/322 (25%), Positives = 148/322 (45%), Gaps = 47/322 (14%)
Query: 87 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE-----MVPGKVELQEKVVQV 141
+ A + G H + L+ +G+VYS+GC D G LG +V E GK + + VV +
Sbjct: 498 IAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGK-QAGKHVVHI 556
Query: 142 SAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ----LDVPVVKVASG 197
+ G +++AA+T +G ++ WG R N G +G + +P+ V L V V SG
Sbjct: 557 ACGSTYSAAITAEGELYTWG--RGNYGRLG-HGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 198 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 257
+ + +T +G +++ G G+ G+LG RGG G + PK + V
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLG--------RGGSDGCK---TPKLIEKLQDLDVVKV 662
Query: 258 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 317
R CG+ F+ A++ +G VY +G + +LG E P+ L + K + +
Sbjct: 663 R-----CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQG--KKVIDVA 715
Query: 318 GGQHHTVCMDSEGKAYSLGRAE----YGRLGLGEGAEEKSIPTLISRLPAVSSVACGASV 373
G H + + + + +S G + + L + + E ++P L ++ + +ACG +
Sbjct: 716 AGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK-PEPAALPGLDTK--HIVGIACGPA- 771
Query: 374 GYAVTKDGRVFAWGMGTNYQLG 395
+ FAW + + +G
Sbjct: 772 --------QSFAWSSCSEWSIG 785
Score = 79.0 bits (193), Expect = 8e-15
Identities = 67/239 (28%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 198 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 257
+D + G +Y G +GQLG G +G + + C L + +
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG----------GIEGAKVKVPTPCEALAT------L 3985
Query: 258 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 317
R G FA++ +G +Y G +LG GTES P L S ++ V +
Sbjct: 3986 RPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVN 4045
Query: 318 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGY 375
G H + + SEG+ YS G AE G+LG G P +I L + VA G +
Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIESLRGIEVVDVAAGGAHSA 4104
Query: 376 AVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 434
VT G ++ WG G +LG ED P + Q V ++ SG T+ L D
Sbjct: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163
Score = 75.5 bits (184), Expect = 9e-14
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 30/259 (11%)
Query: 44 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 101
H + T G V + G+GD G+LG M KP L+ + + G H+ L+
Sbjct: 3058 HATALTVDGKVFSWGEGDDGKLGHFSR-MNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
Query: 102 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAG--DSHTAALTDDGRVFL 159
SG++Y++G + G LG + + KV L +V+QV+ G D+ T ALTD+G VF
Sbjct: 3117 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 3176
Query: 160 WGSFRDNNGVIGLL--EPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGC 215
WG +G G L + +P ++ V ++ G + LT G ++T G
Sbjct: 3177 WG-----DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Query: 216 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 275
G+ +LG ++ + P+ V G RG + GA A++
Sbjct: 3232 GDYFRLGHGSDVHVRK-----------PQVV----EGLRGK-KIVHVAVGALHCLAVTDS 3275
Query: 276 GHVYGFGLSNYHQLGTPGT 294
G VY +G +++ Q G T
Sbjct: 3276 GQVYAWGDNDHGQQGNGTT 3294
Score = 75.5 bits (184), Expect = 9e-14
Identities = 80/296 (27%), Positives = 132/296 (44%), Gaps = 37/296 (12%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPE-DVVQAEAGGMHTVCLSKSGQVYSFGC 110
G V + G+ + G+LG G + + S+ +VV AGG H+ C++ +G +Y++G
Sbjct: 4058 GEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGK 4117
Query: 111 NDEGALGRDTSVEGSEMVPGKVELQE--KVVQVS--AGDSHTAALTDDGRVFLWG----S 162
G LG S + ++ P VE + +VV ++ +GD+ T LTDD V+ WG
Sbjct: 4118 GRYGRLGHSDSED--QLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYG 4175
Query: 163 FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222
G G PMK + + VVKV G+ V LT G +YT G G+ +LG
Sbjct: 4176 KLGRGGSDGCKVPMK-----IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
Query: 223 RVPELFANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 281
+ R + QGL+ K + + + G+ + +G VY +
Sbjct: 4231 HGSDDHVRRPRQVQGLQG---KKVIAIAT--------------GSLHCVCCTEDGEVYTW 4273
Query: 282 GLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
G ++ QLG T + P+ + + + + V + G HT+ S K S G+
Sbjct: 4274 GDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV--ACGSAHTLAW-STSKPASAGK 4326
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/188 (32%), Positives = 97/188 (51%), Gaps = 14/188 (7%)
Query: 43 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGMHTVC 98
+H + T G + T G+G G+LG ++ ++ KP LV + + +G T+C
Sbjct: 4101 AHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
Query: 99 LSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGR 156
L+ V+S+G D G LGR S +G + VP K++ VV+V G + ALT G
Sbjct: 4160 LTDDDTVWSWGDGDYGKLGRGGS-DGCK-VPMKIDSLTGLGVVKVECGSQFSVALTKSGA 4217
Query: 157 VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLG 214
V+ WG + G + +++ P QVQ V+ +A+G+ H V T DG++YT G
Sbjct: 4218 VYTWGKGDYHRLGHGSDDHVRR---PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
Query: 215 CGEQGQLG 222
++GQLG
Sbjct: 4275 DNDEGQLG 4282
Score = 71.2 bits (173), Expect = 2e-12
Identities = 62/193 (32%), Positives = 91/193 (47%), Gaps = 16/193 (8%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERK-KPALVSIPEDVVQAEAGG--MH 95
+C SH + T G + T G G+ G+LG G+N + K K V + V+Q G
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQ 3164
Query: 96 TVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTD 153
T+ L+ G V+S+G D G LGR S EG +P +E + V Q+ G + ALT
Sbjct: 3165 TLALTDEGLVFSWGDGDFGKLGRGGS-EGCN-IPQNIERLNGQGVCQIECGAQFSLALTK 3222
Query: 154 DGRVFLWGS---FRDNNGV-IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGD 209
G V+ WG FR +G + + +P V+ +V VA G H + +T G
Sbjct: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQ-----VVEGLRGKKIVHVAVGALHCLAVTDSGQ 3277
Query: 210 LYTLGCGEQGQLG 222
+Y G + GQ G
Sbjct: 3278 VYAWGDNDHGQQG 3290
Score = 70.9 bits (172), Expect = 2e-12
Identities = 56/187 (29%), Positives = 99/187 (52%), Gaps = 8/187 (4%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGM 94
+C ++ + T G + T G+G+ G+LG G + + P LV+ + + V +G
Sbjct: 557 ACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDA 615
Query: 95 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTD 153
T+ ++++GQV+S+G D G LGR S +G + +LQ+ VV+V G + ALT
Sbjct: 616 QTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTK 674
Query: 154 DGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTL 213
DG+V+ WG + G E ++ + +Q V+ VA+G+ H + LT D ++++
Sbjct: 675 DGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQ-GKKVIDVAAGSTHCLALTEDSEVHSW 733
Query: 214 GCGEQGQ 220
G +Q Q
Sbjct: 734 GSNDQCQ 740
Score = 60.5 bits (145), Expect = 3e-09
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 5/125 (4%)
Query: 33 RVPGARSCQVSHRSHS----TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVV 87
R+ G CQ+ + T+ G+V T G+GD +LG G +V RK + + + +V
Sbjct: 3201 RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
Query: 88 QAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSH 147
G +H + ++ SGQVY++G ND G G T+ + + +K+ +V+ G SH
Sbjct: 3261 HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSH 3320
Query: 148 TAALT 152
+ A T
Sbjct: 3321 SVAWT 3325
Score = 57.0 bits (136), Expect = 3e-08
Identities = 37/106 (34%), Positives = 60/106 (56%), Gaps = 7/106 (6%)
Query: 49 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 107
T+ G V T G+GD +LG G + R+ + + + V+ G +H VC ++ G+VY+
Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYT 4272
Query: 108 FGCNDEGALGRDT--SVEGSEMVPGKVELQ-EKVVQVSAGDSHTAA 150
+G NDEG LG T +++ +V LQ +KV +V+ G +HT A
Sbjct: 4273 WGDNDEGQLGDGTTNAIQRPRLV---AALQGKKVNRVACGSAHTLA 4315
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 109 bits (273), Expect = 4e-24
Identities = 108/386 (27%), Positives = 172/386 (44%), Gaps = 73/386 (18%)
Query: 88 QAEAGGMHTVCLSKSGQVYSF-----GCNDEGALGRDTSVEGSEMVPGKVE-LQEKVV-Q 140
Q AG H ++ ++Y++ G G LG + S P VE LQ K + Q
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGD--KASYRQPKHVEKLQGKAIRQ 430
Query: 141 VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGL--------LEPMKKSMVPVQVQLDVPVV 192
VS GD T +TD+G+++ +GS D G +G+ LEPM+ + L PV
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGS--DYYGCMGVDKVAGPEVLEPMQLNFF-----LSNPVE 483
Query: 193 KVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRG 252
+V+ G++H+V+LT + ++Y+ GCGE G+LG + +++ VPK +++ +
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLG-----LDSEEDYYTPQKVDVPKALIIVA-- 536
Query: 253 SRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLG----------------TPGTES 296
CG TF ++ G V GL+ +++LG P T S
Sbjct: 537 ---------VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS 587
Query: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356
+ + L+ +K T + G+ HT +D G+ + G + G+LG+G + I
Sbjct: 588 FTLAKQLSFYKIRT-----IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINL 642
Query: 357 LISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT-------GQDEDAWSPVE 407
L L V V+CG A T D +FAWG G N +L G D P
Sbjct: 643 LGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRP 702
Query: 408 MMGKQLENRVVLSVSSGGQHTVLLVK 433
+ G V +S G HT+L+V+
Sbjct: 703 IFGSL---HHVPDLSCRGWHTILIVE 725
Score = 69.3 bits (168), Expect = 6e-12
Identities = 76/293 (25%), Positives = 115/293 (39%), Gaps = 40/293 (13%)
Query: 21 KKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGL----GENVMERKK 76
K V+ + A R+V SC T+ G + G G +G+ G V+E +
Sbjct: 418 KHVEKLQGKAIRQV----SCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQ 473
Query: 77 PALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 136
+ V Q G H V L+++ +VYS+GC + G LG D+ E P KV++ +
Sbjct: 474 LNFF-LSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDS--EEDYYTPQKVDVPK 530
Query: 137 K--VVQVSAGDSHTAALTDDGRVFLWG-----SFRDNNGVIGLLEPMKKSMVPVQVQLDV 189
+V V G T LT G+V G N + G++ VP +
Sbjct: 531 ALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTL 590
Query: 190 -------PVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLV 242
+ +A G H + G L T GC + GQLG N R G+ L
Sbjct: 591 AKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG-----VGNYKKRLGINLLGG 645
Query: 243 PKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE 295
P G + +R CG FT A + + H++ +G +L TE
Sbjct: 646 P-------LGGKQVIRVS---CGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 15/147 (10%)
Query: 300 PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL-----GRAEYGRLGLGEGAEEKSI 354
PQ L K+ + +G H V + E + Y+ G +G+LG G+ A +
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAV-VTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ- 416
Query: 355 PTLISRLP--AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 412
P + +L A+ V+CG VT +G+++A+G ++Y G D+ A P + Q
Sbjct: 417 PKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFG--SDYYGCMGVDKVA-GPEVLEPMQ 473
Query: 413 LE---NRVVLSVSSGGQHTVLLVKDKE 436
L + V VS G H V+L ++KE
Sbjct: 474 LNFFLSNPVEQVSCGDNHVVVLTRNKE 500
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 67 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 123
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
Query: 124 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 183
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
Query: 184 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 241
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Query: 242 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 294
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 295 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 354
+ +P+ + F + G + + G + G R E
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
Query: 355 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 411
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
Query: 412 QLENRVVLSVSSGGQHTVLLVKDKEQS 438
L+ V+ G H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
Score = 59.3 bits (142), Expect = 7e-09
Identities = 51/182 (28%), Positives = 75/182 (41%), Gaps = 28/182 (15%)
Query: 31 SRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQA 89
S V + +C +H TE G V G+ +GQLGLG PA + + + +
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKM 259
Query: 90 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL----- 134
G ++ + G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 135 ---------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQV 185
V V+ G +HT L RVF WG G +G E K MVP V
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLV 376
Query: 186 QL 187
+L
Sbjct: 377 KL 378
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 67 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 123
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
Query: 124 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 183
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
Query: 184 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 241
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Query: 242 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 294
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 295 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 354
+ +P+ + F + G + + G + G R E
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
Query: 355 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 411
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
Query: 412 QLENRVVLSVSSGGQHTVLLVKDKEQS 438
L+ V+ G H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
Score = 59.3 bits (142), Expect = 7e-09
Identities = 51/182 (28%), Positives = 75/182 (41%), Gaps = 28/182 (15%)
Query: 31 SRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQA 89
S V + +C +H TE G V G+ +GQLGLG PA + + + +
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKM 259
Query: 90 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL----- 134
G ++ + G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 135 ---------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQV 185
V V+ G +HT L RVF WG G +G E K MVP V
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLV 376
Query: 186 QL 187
+L
Sbjct: 377 KL 378
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 100 bits (248), Expect = 3e-21
Identities = 90/318 (28%), Positives = 148/318 (46%), Gaps = 31/318 (9%)
Query: 52 GLVLTLGQGDVGQLGLGE----NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYS 107
G VL G+G G+LG G +V+ + +V + H++ L++SG+V+S
Sbjct: 4046 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105
Query: 108 FGCNDEGALGRDTSVEGSEMVPGKVE-LQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRD 165
+G D G LG S + P ++E LQ E+VVQ+S G H+A +T DG++F +G+
Sbjct: 4106 WGDGDYGKLGHGNS--DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--G 4161
Query: 166 NNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL-YTLGCGEQGQLGR 223
+ G +GL K + L+ + +VA G +H + ++ADG + + G G+ G+LG
Sbjct: 4162 DYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG- 4220
Query: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
N + +++ V + +K CG F+ A++ +GHVY FG
Sbjct: 4221 ----LGNSTAKSSPQKIDVLCGIGIKK-----------VACGTQFSVALTKDGHVYTFGQ 4265
Query: 284 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 343
L + PQ + V G HT+ + S G Y+ G G+L
Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV--GAEHTLALASNGDVYAWGSNSEGQL 4323
Query: 344 GLGEGAEEKSIPTLISRL 361
GLG + PTL++ L
Sbjct: 4324 GLGHTNHVRE-PTLVTGL 4340
Score = 95.1 bits (235), Expect = 1e-19
Identities = 93/348 (26%), Positives = 160/348 (45%), Gaps = 37/348 (10%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP----EDVVQAEAGGMHTVCLSKSGQVYS 107
G V G+G G+LGLG++ + L P + V ++ HT+ + G+V+S
Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
Query: 108 FGCNDEGALGRDTSVEGSEMVPGKVE--LQEKVVQ-VSAGDSHTAALTDDGRVFLWGSFR 164
+G D G LG S ++ P ++ LQ KVV VSAG H+AA+T+DG ++ WG
Sbjct: 482 WGDGDYGKLGHGNS--STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWG--E 537
Query: 165 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG-DLYTLGCGEQGQLGR 223
+ G +G + ++ +P V+ V +V+ G+ H + L+ DG +++ G G+ G+L
Sbjct: 538 GDFGRLGHGDSNSRN-IPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKL-- 594
Query: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
G R+ PK + +G + + G+ + A++ G VY +G
Sbjct: 595 ---------GHGDTNRVYKPKVI----EALQG-MFIRKVCAGSQSSLALTSTGQVYAWGC 640
Query: 284 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 343
LG +E+ + L +T+ V S G H + + + + Y+ G G+
Sbjct: 641 GAC--LGCGSSEATALRPKLIEELAATRI-VDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697
Query: 344 GLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVT---KDGRVFAW 386
G G + P +S L A+ ++ G S A T +D +V AW
Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745
Score = 94.4 bits (233), Expect = 2e-19
Identities = 83/284 (29%), Positives = 132/284 (46%), Gaps = 25/284 (8%)
Query: 44 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKS 102
H TE G V + G GD G+LG G + +R+ + ++ E+VVQ G H+ ++
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152
Query: 103 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLW 160
G++++FG D G LG + ++ +P +V E ++ QV+ G +HT A++ DG + +W
Sbjct: 4153 GKLFTFGNGDYGRLGLGNT--SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSM-VW 4209
Query: 161 GSFRDNNGVIGL-LEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 219
+ G +GL K S + V + + KVA G V LT DG +YT G Q
Sbjct: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG---QD 4266
Query: 220 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 279
+L +PE A R +L V +D GA T A++ G VY
Sbjct: 4267 RLIGLPEGRARNHNRPQQIPVL-------------AGVIIEDVAVGAEHTLALASNGDVY 4313
Query: 280 GFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 323
+G ++ QLG T P +T + K+ S G+ H+
Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQG--KNVRQISAGRCHS 4355
Score = 94.0 bits (232), Expect = 2e-19
Identities = 109/383 (28%), Positives = 163/383 (42%), Gaps = 42/383 (10%)
Query: 58 GQGDVGQLG-LGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGAL 116
G G GQL G NVM PA Q G T + +G V + G G L
Sbjct: 4003 GAGRHGQLAEAGRNVMV---PAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059
Query: 117 GRDTSVEGSEM-----VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG 171
G+ S + + + G V Q +V D H+ ALT+ G VF WG + G +G
Sbjct: 4060 GQGNSDDLHVLTVISALQGFVVTQ--LVTSCGSDGHSMALTESGEVFSWGD--GDYGKLG 4115
Query: 172 LLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFA 229
++ P Q++ VV+++ G H ++T+DG L+T G G+ G+LG
Sbjct: 4116 HGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG-----LG 4169
Query: 230 NRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQ 288
N ++ ER+ + + G V CG T A+S +G V+ FG +Y +
Sbjct: 4170 NTSNKKLPERVTALEGYQI------GQVA-----CGLNHTLAVSADGSMVWAFGDGDYGK 4218
Query: 289 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEG 348
LG + + PQ + V G +V + +G Y+ G+ +GL EG
Sbjct: 4219 LGLGNSTAKSSPQKIDVLCGIGIKKVAC--GTQFSVALTKDGHVYTFGQDRL--IGLPEG 4274
Query: 349 -AEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 405
A + P I L V VA GA A+ +G V+AWG + QLG G P
Sbjct: 4275 RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREP 4334
Query: 406 VEMMGKQLENRVVLSVSSGGQHT 428
+ G Q +N V +S+G H+
Sbjct: 4335 TLVTGLQGKN--VRQISAGRCHS 4355
Score = 92.4 bits (228), Expect = 7e-19
Identities = 110/411 (26%), Positives = 167/411 (40%), Gaps = 42/411 (10%)
Query: 31 SRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQL--GLGENVMERKKPALVSIPEDVVQ 88
SR S Q +E V G QL G E +++ P L D
Sbjct: 351 SRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQ---PKLAPSFSDAQT 407
Query: 89 AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAG---D 145
EAG T +S G V + G G LG S S + E + +VS+ D
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
Query: 146 SHTAALTDDGRVFLWGSF---RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLV 202
HT A T +G VF WG + +G + K P+Q ++ VV V++G H
Sbjct: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKV---VVCVSAGYRHSA 524
Query: 203 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 262
+T DG+LYT G G+ G+LG N +P ++K + G V
Sbjct: 525 AVTEDGELYTWGEGDFGRLGHGDSNSRN-----------IP--TLVKDISNVGEVS---- 567
Query: 263 FCGAYFTFAISHEGH-VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQH 321
CG+ T A+S +G V+ FG + +LG T + P+ + + + V G
Sbjct: 568 -CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKV--CAGSQ 624
Query: 322 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTK 379
++ + S G+ Y+ G LG G P LI L A + V+ G S A++
Sbjct: 625 SSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682
Query: 380 DGRVFAWGMGTNYQLGTGQDE-DAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
D V+AWG + Q G G P ++ G L+ + +S+G H++
Sbjct: 683 DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG--LDGIAIQQISAGTSHSL 731
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/190 (33%), Positives = 91/190 (47%), Gaps = 11/190 (5%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHT 96
SC H + T G + T G GD G+LGLG N +K P V+ E + Q G HT
Sbjct: 4140 SCGFKHSAVVTSDGKLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHT 4198
Query: 97 VCLSKSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDG 155
+ +S G V++FG D G LG S S V + +V+ G + ALT DG
Sbjct: 4199 LAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDG 4258
Query: 156 RVFLWGSFRDNNGVIGLLEPMKKS---MVPVQVQLDVPVVKVASGNDHLVMLTADGDLYT 212
V+ +G R +IGL E ++ + V V + VA G +H + L ++GD+Y
Sbjct: 4259 HVYTFGQDR----LIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYA 4314
Query: 213 LGCGEQGQLG 222
G +GQLG
Sbjct: 4315 WGSNSEGQLG 4324
Score = 84.0 bits (206), Expect = 3e-16
Identities = 79/288 (27%), Positives = 127/288 (44%), Gaps = 39/288 (13%)
Query: 157 VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCG 216
V+LWG+ R L E + MVP +V G + ++ A+G + G G
Sbjct: 3999 VYLWGAGRHGQ----LAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEG 4054
Query: 217 EQGQLGRVPELFANRGGRQGLERLLVPKCV-------MLKSRGSRGHVRFQDAFCGAYFT 269
G+LG+ G L L V + ++ S GS GH +
Sbjct: 4055 SYGRLGQ--------GNSDDLHVLTVISALQGFVVTQLVTSCGSDGH------------S 4094
Query: 270 FAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 329
A++ G V+ +G +Y +LG ++ P+ + + + + V S G H+ + S+
Sbjct: 4095 MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG--EEVVQMSCGFKHSAVVTSD 4152
Query: 330 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDG-RVFAW 386
GK ++ G +YGRLGLG K +P ++ L + VACG + AV+ DG V+A+
Sbjct: 4153 GKLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
Query: 387 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 434
G G +LG G SP ++ L + V+ G Q +V L KD
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKI--DVLCGIGIKKVACGTQFSVALTKD 4257
Score = 79.0 bits (193), Expect = 8e-15
Identities = 88/354 (24%), Positives = 154/354 (43%), Gaps = 52/354 (14%)
Query: 99 LSKSGQVYSFGCNDEGAL--GRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGR 156
+S++ +VY +G N L G + ++ P + Q + AG T ++ DG
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT----IEAGQYCTFVISTDGS 423
Query: 157 VFLWGSFRDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGND-HLVMLTADGDLYT 212
V G + + G +GL + +S + + + V + G+D H + T +G++++
Sbjct: 424 VRACG--KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
Query: 213 LGCGEQGQLG-------RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 265
G G+ G+LG + P+L +G QG K V+ S G R
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLI--QGPLQG-------KVVVCVSAGYR----------- 521
Query: 266 AYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325
+ A++ +G +Y +G ++ +LG + S IP + N + S G HT+
Sbjct: 522 --HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGE----VSCGSSHTIA 575
Query: 326 MDSEGKA-YSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 382
+ +G+ +S G + G+LG G+ P +I L + V G+ A+T G+
Sbjct: 576 LSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQ 634
Query: 383 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 436
V+AWG G LG G E +++ + R+V VS G H + L D E
Sbjct: 635 VYAWGCGA--CLGCGSSEATALRPKLIEELAATRIV-DVSIGDSHCLALSHDNE 685
Score = 47.0 bits (110), Expect = 3e-05
Identities = 39/110 (35%), Positives = 54/110 (49%), Gaps = 11/110 (10%)
Query: 49 TEPGLVLTLGQGDVGQLGLGEN-VMERKKPALVSIPEDVV--QAEAGGMHTVCLSKSGQV 105
T+ G V T GQ + +GL E +P + + V+ G HT+ L+ +G V
Sbjct: 4255 TKDGHVYTFGQDRL--IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDV 4312
Query: 106 YSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVV-QVSAGDSHTAALT 152
Y++G N EG LG V +V G LQ K V Q+SAG H+AA T
Sbjct: 4313 YAWGSNSEGQLGLGHTNHVREPTLVTG---LQGKNVRQISAGRCHSAAWT 4359
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 97.8 bits (242), Expect = 2e-20
Identities = 92/334 (27%), Positives = 161/334 (48%), Gaps = 34/334 (10%)
Query: 66 GLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGS 125
G ++R++ A S +++QA +G H++ L + +V S G N G LGR + G
Sbjct: 6 GADSRELQRRRTA-GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64
Query: 126 EMVPGKVELQEKVVQ--VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 183
+P ++ E ++ VS G H+ A+ GRVF WG+ + G +G+ E + S P
Sbjct: 65 --LPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPK 120
Query: 184 QVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLL 241
++ D+ +++V+ G+ H + L+ D +++ G GQLG E F ++ Q
Sbjct: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE-FPSQASPQ------ 173
Query: 242 VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE---SCF 298
+ R G Q A GA+ +FA+S G +G+G ++ QL G
Sbjct: 174 -------RVRSLEGIPLAQVAAGGAH-SFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225
Query: 299 IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLI 358
P ++ + KN ++ S G HT + +GK ++ G G+LG E++ P L+
Sbjct: 226 KPLSVGALKNLGVVYI--SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG-PQLV 282
Query: 359 SRLPA-VSSVACGA--SVGYAVTKDGRVFAWGMG 389
R+ VS + CG+ ++ Y T G+V ++G G
Sbjct: 283 ERIDGLVSQIDCGSYHTLAYVHT-TGQVVSFGHG 315
Score = 90.5 bits (223), Expect = 3e-18
Identities = 80/251 (31%), Positives = 110/251 (43%), Gaps = 25/251 (9%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHT 96
SC H G V G G GQLG+GE P + D ++Q G H+
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHS 140
Query: 97 VCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKV--VQVSAGDSHTAALTDD 154
+ LSK QV+S+G N G LG S+ P +V E + QV+AG +H+ AL+
Sbjct: 141 LALSKDSQVFSWGKNSHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
Query: 155 GRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYT 212
G F WGS + +S P+ V ++ VV ++ G+ H +LT DG ++T
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
Query: 213 LGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAI 272
G GQLG P + G Q +ER+ G V D CG+Y T A
Sbjct: 260 FGDNRSGQLGYSPT--PEKRGPQLVERI-------------DGLVSQID--CGSYHTLAY 302
Query: 273 SH-EGHVYGFG 282
H G V FG
Sbjct: 303 VHTTGQVVSFG 313
Score = 80.5 bits (197), Expect = 3e-15
Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 30/252 (11%)
Query: 191 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGR----QGLERLLVPKCV 246
+++ ASG H ++L + + + G +GQLGR A RG Q LE L+V
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG---AQRGELPEPIQALETLIVDL-- 79
Query: 247 MLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG-TESCFIPQNLTS 305
CG + A+ H+G V+ +G + QLG E F P+ + +
Sbjct: 80 ---------------VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124
Query: 306 FKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV- 364
N K + S G +H++ + + + +S G+ +G+LGLG+ ++ P + L +
Sbjct: 125 L-NDIKI-IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182
Query: 365 -SSVACGASVGYAVTKDGRVFAWGMGTNYQLG-TGQDEDAWSPVEMMGKQLENRVVLSVS 422
+ VA G + +A++ G F WG + QL +G++ S + L+N V+ +S
Sbjct: 183 LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYIS 242
Query: 423 SGGQHTVLLVKD 434
G HT +L +D
Sbjct: 243 CGDAHTAVLTQD 254
Score = 72.8 bits (177), Expect = 6e-13
Identities = 77/307 (25%), Positives = 135/307 (43%), Gaps = 38/307 (12%)
Query: 137 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMV-PVQVQLDVPVVKVA 195
+++Q ++G+ H+ L + RV G ++ G +G + + P+Q + V V+
Sbjct: 24 ELLQAASGERHSLLLLTNHRVLSCGD--NSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 196 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 255
G +H + + G ++ G G +GQLG + E E PK +M +
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLG-IGEF---------KEISFTPKKIM-----TLN 126
Query: 256 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSW 313
++ CG Y + A+S + V+ +G +++ QLG G E S PQ + S + +
Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIPLAQ 185
Query: 314 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG--EGAEEKSIPTLISRLP--AVSSVAC 369
V G H+ + G ++ G G+L L + + P + L V ++C
Sbjct: 186 VAAGGA--HSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243
Query: 370 GASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV-EMMGKQLENRV---VLSVSSGG 425
G + +T+DG+VF +G + QLG +SP E G QL R+ V + G
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLG-------YSPTPEKRGPQLVERIDGLVSQIDCGS 296
Query: 426 QHTVLLV 432
HT+ V
Sbjct: 297 YHTLAYV 303
Score = 65.5 bits (158), Expect = 9e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 6/185 (3%)
Query: 249 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 308
++ GS G Q A G + + V G ++ QLG G + +P+ + + +
Sbjct: 16 RTAGSPGAELLQAA-SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74
Query: 309 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--S 366
V S G+ H++ + +G+ ++ G G+LG+GE E P I L +
Sbjct: 75 LIVDLV--SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQ 132
Query: 367 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQ 426
V+CG A++KD +VF+WG ++ QLG G++ + + + + + LE + V++GG
Sbjct: 133 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV-RSLEGIPLAQVAAGGA 191
Query: 427 HTVLL 431
H+ L
Sbjct: 192 HSFAL 196
Score = 61.6 bits (148), Expect = 1e-09
Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 6/123 (4%)
Query: 317 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 374
+ G+ H++ + + + S G G+LG GA+ +P I L V V+CG
Sbjct: 29 ASGERHSLLLLTNHRVLSCGDNSRGQLGR-RGAQRGELPEPIQALETLIVDLVSCGKEHS 87
Query: 375 YAVTKDGRVFAWGMGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 433
AV GRVFAWG G+ QLG G+ E +++P ++M L + ++ VS G H++ L K
Sbjct: 88 LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM--TLNDIKIIQVSCGHYHSLALSK 145
Query: 434 DKE 436
D +
Sbjct: 146 DSQ 148
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 58 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 115
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
Query: 116 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 175
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
Query: 176 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 228
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
Query: 229 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
Query: 287 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 340
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
Query: 341 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 383
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
Query: 384 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 431
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
Score = 68.9 bits (167), Expect = 8e-12
Identities = 93/368 (25%), Positives = 145/368 (39%), Gaps = 44/368 (11%)
Query: 32 RRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAE 90
RR+ G H + T+ G + G GQLGLG + P + Q
Sbjct: 52 RRITGGGG----HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVA 107
Query: 91 AGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTA 149
G T+ L+++GQV S G N G LG +VP +EL +EKVV ++AG H
Sbjct: 108 CGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAV 166
Query: 150 ALTDDGRVFLWGSFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVM 203
A T G VF WG+ + G G P+ K V + + V +G+DH
Sbjct: 167 AATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSAS 226
Query: 204 LTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAF 263
LT G++Y G + GQL AN + + + C + + +
Sbjct: 227 LTDAGEVYVWGSNKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIW 271
Query: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNS 309
G A + G ++ +G ++Y QLG + F+ P ++ S +
Sbjct: 272 SGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHC 331
Query: 310 TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVAC 369
S G H + + G YS G E+G G G A + P + L + S +
Sbjct: 332 LTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLV 389
Query: 370 GASVGYAV 377
G G+++
Sbjct: 390 GCGAGHSL 397
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
Query: 338 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 396
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
Query: 397 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
V +L V+ +++G +H V
Sbjct: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
Score = 34.7 bits (78), Expect = 0.18
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 43 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 85
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
Query: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 145
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
Query: 146 SHTAAL 151
H+ AL
Sbjct: 394 GHSLAL 399
Score = 32.3 bits (72), Expect = 0.87
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 372 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 431
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 89.4 bits (220), Expect = 6e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 129 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 186
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
Query: 187 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
Query: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
Query: 305 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 364
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
Query: 365 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 422
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
Query: 423 SGGQHT 428
HT
Sbjct: 292 CHSAHT 297
Score = 70.5 bits (171), Expect = 3e-12
Identities = 70/243 (28%), Positives = 114/243 (46%), Gaps = 29/243 (11%)
Query: 48 STEPGLVLTLGQGDVGQLGLGENVMERKKPALVS---IPEDVVQAEAGGMHTVCLSKSGQ 104
STE G+V G QLG G + P V + + VV+ G H++ L+ G+
Sbjct: 90 STEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
Query: 105 VYSFGCNDEGALGRDTSVEGSEMVPGKVE---LQEKVVQVSAGDSHTAALTDDGRVFLWG 161
V+++G N+ G +G ++ ++ P KV ++VV ++ G + + A+ D+G V+ WG
Sbjct: 149 VFAWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWG 206
Query: 162 SFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 219
+ NG +G L + PV+V V V ++ G H + LT +G LY G G
Sbjct: 207 --YNGNGQLG-LGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
Query: 220 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 279
QLG N+ LL P +M++ + V A A+ + A + GHVY
Sbjct: 264 QLGT-----GNK------NNLLSPAHIMVE----KERVVEIAACHSAHTSAAKTQGGHVY 308
Query: 280 GFG 282
+G
Sbjct: 309 MWG 311
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 23/215 (10%)
Query: 93 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAAL 151
G H + ++ G VY++G N LG T+ +G V L ++VV+V+ G H+ AL
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMAL 143
Query: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-VVKVASGNDHLVMLTADG 208
DG VF WG +N G +G + P +V L + VV +A G + + +G
Sbjct: 144 AADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRVVGIACGQTSSMAVLDNG 200
Query: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF 268
++Y G GQLG N G + L P V + V CG
Sbjct: 201 EVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV-----AALHSVCVNQIVCGYAH 244
Query: 269 TFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 303
T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/157 (31%), Positives = 77/157 (49%), Gaps = 9/157 (5%)
Query: 18 PKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 77
P +KV T +RV G Q S + + G V G GQLGLG N +
Sbjct: 169 PTPRKV--TNCLHIKRVVGIACGQTSSMA-VLDNGEVYGWGYNGNGQLGLGNNGNQLTPV 225
Query: 78 ALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ- 135
+ ++ V Q G HT+ L+ G +Y++G N G LG T + + + P + ++
Sbjct: 226 RVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG--TGNKNNLLSPAHIMVEK 283
Query: 136 EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNNGVI 170
E+VV+++A S HT AA T G V++WG R + ++
Sbjct: 284 ERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVIL 320
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 77 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 128
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
Query: 129 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 176
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
Query: 177 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 236
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
Query: 237 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 296
G V A+S +G ++G+G S Y QL + +
Sbjct: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
Query: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
Query: 357 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 405
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
Query: 406 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 433
V M G+ ++ V+ G H V L K
Sbjct: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
Score = 30.4 bits (67), Expect = 3.3
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 40 CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCL 99
C +SH + T G + G+ G LG+G + ++ P V++P + V G H V L
Sbjct: 401 CGLSHFAALTNKGELFVWGKNIRGCLGIG-RLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459
Query: 100 SKS 102
+KS
Sbjct: 460 AKS 462
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 83.2 bits (204), Expect = 4e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 54 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 111
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
Query: 112 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 168
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
Query: 169 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 225
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
Query: 226 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
Query: 286 YHQLGTPGTESCFIPQNLTSFKN 308
Y QLGT + P +T K+
Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Score = 78.2 bits (191), Expect = 1e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 200 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 259
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
Query: 260 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 319
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
Query: 320 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 377
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Query: 378 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 428
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 289 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 346
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
Query: 347 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 405
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 406 VEMMGKQLENRVVLSVSSG 424
+ G L+N+VV++++ G
Sbjct: 196 RRVTG-CLQNKVVVTIACG 213
Score = 58.5 bits (140), Expect = 1e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 50 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 107
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
Query: 108 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 165
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
Query: 166 NNGVI 170
+ ++
Sbjct: 340 QSVIL 344
Score = 30.0 bits (66), Expect = 4.3
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHT 96
+C +H T+ G V G GQLG G N + P V++ +D + A HT
Sbjct: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHT 321
Query: 97 -VCLSKSGQVYSFG 109
++ G VY +G
Sbjct: 322 SAAKTQGGHVYMWG 335
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 81.3 bits (199), Expect = 2e-15
Identities = 89/379 (23%), Positives = 156/379 (41%), Gaps = 58/379 (15%)
Query: 85 DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK------- 137
+VVQ AG +++SG++ + GA G ++PG VE +
Sbjct: 333 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-------GGGSLLPGAVEQPQPQFISRFL 385
Query: 138 -------VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEPMKKSMVPVQVQLD 188
+ V+ GD TA LTD G + +GS +NG +G L + + + V+ L
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGS--GSNGCLGHGSLTDISQPTI-VEALLG 442
Query: 189 VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVML 248
+V+VA G H++ L+ + +L+ G G+ G+LG R +++ +P
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLG-----LGTRESHSCPQQVPMPP---- 493
Query: 249 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG------------TES 296
G Q CG + ++ G G + +++LG E
Sbjct: 494 ---GQEA----QRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEE 546
Query: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356
L S + + G H+ + + G Y+ G ++G+LG ++ P
Sbjct: 547 ALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PC 605
Query: 357 LISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 414
+ L + + VACG + A+ + V++WG G +LG +DEDA P + +
Sbjct: 606 KVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETH 664
Query: 415 NRVVLSVSSGGQHTVLLVK 433
V SVS +T+L V+
Sbjct: 665 PYTVTSVSCCHGNTLLAVR 683
Score = 77.0 bits (188), Expect = 3e-14
Identities = 71/259 (27%), Positives = 110/259 (42%), Gaps = 36/259 (13%)
Query: 49 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVCLSKSGQVY 106
T+ G+++T G G G LG G ++ + +P +V + ++VQ G H + LS +++
Sbjct: 407 TDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELF 465
Query: 107 SFGCNDEGALGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTDDGRVFLWGSFR 164
++G D G LG T S P +V + ++ +V G + LT G+ GS R
Sbjct: 466 AWGRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNR 523
Query: 165 DNNGVIGLL----EPMKKSMVPVQVQLDV---------PVVKVASGNDHLVMLTADGDLY 211
N + L EP+ V + + P++ + G H +TA GD Y
Sbjct: 524 FNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCY 583
Query: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
T G + GQLG RG R K +G G ++ CG FT A
Sbjct: 584 TFGSNQHGQLG----TNTRRGSR-----------APCKVQGLEG-IKMAMVACGDAFTVA 627
Query: 272 ISHEGHVYGFGLSNYHQLG 290
I E VY +G +LG
Sbjct: 628 IGAESEVYSWGKGARGRLG 646
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/324 (25%), Positives = 130/324 (40%), Gaps = 41/324 (12%)
Query: 134 LQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP------VQVQL 187
L +VVQV+AG + A +T GR+ LW + G LL + P ++ Q
Sbjct: 330 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS 389
Query: 188 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 247
V + VA G+ LT G + T G G G LG G + + + + ++
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLG--------HGSLTDISQPTIVEALL 441
Query: 248 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 307
G+ Q A CGA A+S E ++ +G + +LG ES PQ +
Sbjct: 442 -------GYEMVQVA-CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPP 493
Query: 308 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-----------EGAEEKSIPT 356
V G ++ + G+A + G + +LGL + EE T
Sbjct: 494 GQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
Query: 357 LISRLP----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 412
L+ P + S+ G + AVT G + +G + QLGT + +P ++ G
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-- 609
Query: 413 LENRVVLSVSSGGQHTVLLVKDKE 436
LE + V+ G TV + + E
Sbjct: 610 LEGIKMAMVACGDAFTVAIGAESE 633
Score = 33.5 bits (75), Expect = 0.39
Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 6/96 (6%)
Query: 43 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQA--EAGGMHTVCLS 100
+H + T G T G GQLG R P V E + A G TV +
Sbjct: 571 AHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PCKVQGLEGIKMAMVACGDAFTVAIG 629
Query: 101 KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 136
+VYS+G G LGR G +P V+L E
Sbjct: 630 AESEVYSWGKGARGRLGRRDEDAG---LPRPVQLDE 662
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 80.1 bits (196), Expect = 4e-15
Identities = 78/313 (24%), Positives = 128/313 (40%), Gaps = 41/313 (13%)
Query: 137 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVAS 196
K+ V G H L+ DG+ F + ++ K + + + ++++
Sbjct: 98 KIHSVDQGAEHMLILSSDGKPFEYDNYS------------MKHLRFESILQEKKIIQITC 145
Query: 197 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH 256
G+ H + L+ G+L+ G GQLG V F + Q +E L
Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL--------------AG 190
Query: 257 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF 316
V G + A+S G++Y +G + QLG TES P + N +V
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC 250
Query: 317 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 374
G H+ + +G ++ G ++G+LG E P L++ L V+ +ACG
Sbjct: 251 GGS--HSALLTQDGLLFTFGAGKHGQLGHNSTQNELR-PCLVAELVGYRVTQIACGRWHT 307
Query: 375 YAVTKD-GRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSS--------GG 425
A D G+VF++G G + QLG G D P+ + E + S +S GG
Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367
Query: 426 QHTVLLVKDKEQS 438
++LL KE S
Sbjct: 368 NQSILLWIKKENS 380
Score = 73.2 bits (178), Expect = 4e-13
Identities = 58/192 (30%), Positives = 93/192 (48%), Gaps = 14/192 (7%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALV----SIPEDVVQAEAGGM 94
+C H ++ G + GQ GQLG+G P +V +P + Q AG
Sbjct: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVP--LAQISAGEA 201
Query: 95 HTVCLSKSGQVYSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 152
H++ LS SG +YS+G N+ G LG S + ++ G +KV V+ G SH+A LT
Sbjct: 202 HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLD--NQKVEFVACGGSHSALLT 259
Query: 153 DDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL-DVPVVKVASGNDHLVMLTAD-GDL 210
DG +F +G+ +G +G + + +L V ++A G H + +D G +
Sbjct: 260 QDGLLFTFGA--GKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKV 317
Query: 211 YTLGCGEQGQLG 222
++ G G+ GQLG
Sbjct: 318 FSFGSGKDGQLG 329
Score = 72.4 bits (176), Expect = 8e-13
Identities = 70/313 (22%), Positives = 137/313 (43%), Gaps = 41/313 (13%)
Query: 51 PGLVLTLGQGDVG----QLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 106
PG + L +G G QL G K + + + G H + LS G+ +
Sbjct: 60 PGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPF 119
Query: 107 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
+ L ++ ++ ++K++Q++ GD H+ AL+ G +F WG ++
Sbjct: 120 EYDNYSMKHLRFESILQ-----------EKKIIQITCGDYHSLALSKGGELFAWG--QNL 166
Query: 167 NGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG-R 223
+G +G+ + P V+ VP+ ++++G H + L+ G++Y+ G E GQLG
Sbjct: 167 HGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLG 226
Query: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
E + +GL+ + + + CG + ++ +G ++ FG
Sbjct: 227 HTESKDDPSLIEGLD-----------------NQKVEFVACGGSHSALLTQDGLLFTFGA 269
Query: 284 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE-GKAYSLGRAEYGR 342
+ QLG T++ P + + + + G+ HT+ S+ GK +S G + G+
Sbjct: 270 GKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
Query: 343 LGLGEGAEEKSIP 355
LG G G ++ +P
Sbjct: 328 LGNG-GTRDQLMP 339
Score = 49.7 bits (117), Expect = 5e-06
Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 8/114 (7%)
Query: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHT 96
+C SH + T+ GL+ T G G GQLG + +P LV+ + V Q G HT
Sbjct: 249 ACGGSHSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHT 307
Query: 97 VC-LSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 149
+ +S G+V+SFG +G LG + + +P KV E++ +SHT+
Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKL----ESHTS 357
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 69.7 bits (169), Expect = 5e-12
Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)
Query: 188 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 247
D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80
Query: 248 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 307
G V A+S +G ++G+G S Y QL + + F
Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
Query: 308 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 362
K GG V ++ EG + G YG LG G E ++P +I
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192
Query: 363 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 415
VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251
Query: 416 RVVLSVSSGGQHTVLLVK 433
V+ G H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264
Score = 55.5 bits (132), Expect = 1e-07
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)
Query: 109 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 163
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 164 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 223
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
Query: 284 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 335
Y LG P +P+ LT F N G + ++G+ +
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221
Query: 336 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 370
G+ G LG+G E++ P ++ VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 144
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
Query: 145 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 194
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
Query: 195 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
Query: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 69.7 bits (169), Expect = 5e-12
Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)
Query: 188 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 247
D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80
Query: 248 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 307
G V A+S +G ++G+G S Y QL + + F
Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
Query: 308 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 362
K GG V ++ EG + G YG LG G E ++P +I
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192
Query: 363 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 415
VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251
Query: 416 RVVLSVSSGGQHTVLLVK 433
V+ G H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264
Score = 55.5 bits (132), Expect = 1e-07
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)
Query: 109 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 163
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 164 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 223
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
Query: 284 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 335
Y LG P +P+ LT F N G + ++G+ +
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221
Query: 336 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 370
G+ G LG+G E++ P ++ VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 144
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
Query: 145 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 194
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
Query: 195 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
Query: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 68.6 bits (166), Expect = 1e-11
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 109
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
Query: 110 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
N+ G L R+ + +G + EL E QV R
Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
Query: 167 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 109 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 163
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
Query: 164 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 217
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
Query: 218 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 277
G+L +P A R R L P+ +R + GA + G
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
Query: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
Query: 338 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 360
E G+L L GE GAE+ + P L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
Query: 361 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 414
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
Query: 415 NRVVLSVSSGGQHTVLLVKDKEQS 438
V +V+ G +T + +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 68.6 bits (166), Expect = 1e-11
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 109
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
Query: 110 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
N+ G L R+ + +G + EL E QV R
Sbjct: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
Query: 167 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 109 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 163
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
Query: 164 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 217
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
Query: 218 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 277
G+L +P A R R L P+ +R + GA + G
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
Query: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
Query: 338 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 360
E G+L L GE GAE+ + P L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
Query: 361 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 414
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
Query: 415 NRVVLSVSSGGQHTVLLVKDKEQS 438
V +V+ G +T + +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 60.5 bits (145), Expect = 3e-09
Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 5/155 (3%)
Query: 276 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 335
G V+ +G ++ +LG G+E C IPQN+ + G + + G ++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 782
Query: 336 GRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQL 394
G+ +Y RLG + + + R + VA GA AV G+V+AWG + Q
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 395 GTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
G G P+ + G LE + ++ V+ G H+V
Sbjct: 843 GNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 875
Score = 58.9 bits (141), Expect = 9e-09
Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 110
GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784
Query: 111 NDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVI 170
D LG + V ++ + +K+V V+ G H A+ D G+V+ WG
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844
Query: 171 GLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 205
G +K M+ VQ ++ VA G+ H V T
Sbjct: 845 GTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 878
Score = 55.1 bits (131), Expect = 1e-07
Identities = 41/126 (32%), Positives = 64/126 (50%), Gaps = 7/126 (5%)
Query: 33 RVPGARSCQVSHRSHS----TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVV 87
R+ G CQ+ + T+ G+V T G+GD +LG +V RK + + + +V
Sbjct: 754 RLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIV 813
Query: 88 QAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDS 146
G H + + SGQVY++G ND G G T+V M+ +E Q K++ V+ G S
Sbjct: 814 HVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSS 872
Query: 147 HTAALT 152
H+ A T
Sbjct: 873 HSVAWT 878
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/110 (35%), Positives = 55/110 (50%), Gaps = 6/110 (5%)
Query: 330 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 387
G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 388 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 437
G ++LG D + G L + ++ V+ G QH L V D Q
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 830
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 24/186 (12%)
Query: 198 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254
+D+ +LT G +++ G G+ G+LGR GG +G +P+ + + +
Sbjct: 712 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 758
Query: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 314
G + + CGA F A++ G V+ +G +Y +LG Q + + V
Sbjct: 759 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHV 815
Query: 315 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 372
G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S
Sbjct: 816 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 872
Query: 373 VGYAVT 378
A T
Sbjct: 873 HSVAWT 878
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 60.1 bits (144), Expect = 4e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 274 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 333
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
Query: 334 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 391
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
Query: 392 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
Q G G P + G LE + ++ V+ G H+V
Sbjct: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Score = 57.4 bits (137), Expect = 3e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 329 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 386
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
Query: 387 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 437
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Query: 33 RVPGARSCQVSHRSHS----TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVV 87
R+ G CQ+ + T+ G+V T G+GD +LG +V RK + + + +V
Sbjct: 52 RLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIV 111
Query: 88 QAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSH 147
G H + + SGQVY++G ND G G T+ + + +K++ V+ G SH
Sbjct: 112 HVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSH 171
Query: 148 TAALT 152
+ A T
Sbjct: 172 SVAWT 176
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 53 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 111
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 112 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 169
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
Query: 170 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 205
G +K + VQ ++ VA G+ H V T
Sbjct: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
Score = 50.4 bits (119), Expect = 3e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 191 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 250
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
Query: 251 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 310
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
Query: 311 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 368
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
Query: 369 CGASVGYAVT 378
CG+S A T
Sbjct: 167 CGSSHSVAWT 176
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 60.1 bits (144), Expect = 4e-09
Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 7/156 (4%)
Query: 276 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 335
G V+ +G ++ +LG G+E C IPQN+ + G + + G ++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 732
Query: 336 GRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQ 393
G+ +Y RLG + P ++ L + VA GA AV G+V+AWG + Q
Sbjct: 733 GKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791
Query: 394 LGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
G G P+ + G LE + ++ V+ G H+V
Sbjct: 792 QGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 825
Score = 58.9 bits (141), Expect = 9e-09
Identities = 49/157 (31%), Positives = 73/157 (46%), Gaps = 6/157 (3%)
Query: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 110
GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 111 NDEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 168
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 169 VIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 205
G +K M+ VQ ++ VA G+ H V T
Sbjct: 793 GNGTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 828
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/110 (36%), Positives = 56/110 (50%), Gaps = 6/110 (5%)
Query: 330 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 387
G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 388 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 437
G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 780
Score = 55.5 bits (132), Expect = 1e-07
Identities = 41/126 (32%), Positives = 64/126 (50%), Gaps = 7/126 (5%)
Query: 33 RVPGARSCQVSHRSHS----TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVV 87
R+ G CQ+ + T+ G+V T G+GD +LG +V RK + + + +V
Sbjct: 704 RLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIV 763
Query: 88 QAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDS 146
G H + + SGQVY++G ND G G T+V M+ +E Q K++ V+ G S
Sbjct: 764 HVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSS 822
Query: 147 HTAALT 152
H+ A T
Sbjct: 823 HSVAWT 828
Score = 48.9 bits (115), Expect = 9e-06
Identities = 51/186 (27%), Positives = 84/186 (45%), Gaps = 24/186 (12%)
Query: 198 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254
+D+ +LT G +++ G G+ G+LGR GG +G +P+ + + +
Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 708
Query: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 314
G + + CGA F A++ G V+ +G +Y +LG PQ + + V
Sbjct: 709 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHV 765
Query: 315 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 372
G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S
Sbjct: 766 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 822
Query: 373 VGYAVT 378
A T
Sbjct: 823 HSVAWT 828
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,751,555
Number of Sequences: 37866
Number of extensions: 817523
Number of successful extensions: 2832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1868
Number of HSP's gapped (non-prelim): 278
length of query: 438
length of database: 18,247,518
effective HSP length: 105
effective length of query: 333
effective length of database: 14,271,588
effective search space: 4752438804
effective search space used: 4752438804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.