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Search of human proteins with 114796644
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114796644 regulator of chromosome condensation 1 isoform a
[Homo sapiens]
(452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 915 0.0
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 874 0.0
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 834 0.0
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 834 0.0
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 834 0.0
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 834 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 142 6e-34
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 142 6e-34
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 136 4e-32
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 136 4e-32
gi|7657152 hect domain and RLD 3 [Homo sapiens] 132 6e-31
gi|126032348 hect domain and RLD 2 [Homo sapiens] 124 2e-28
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 109 4e-24
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 104 2e-22
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 100 4e-21
gi|61563742 hect domain and RLD 6 [Homo sapiens] 98 2e-20
gi|6912330 deafness locus associated putative guanine nucleotide... 97 4e-20
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 89 6e-18
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 87 2e-17
gi|4557445 regulator of chromosome condensation and BTB domain c... 83 4e-16
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 81 2e-15
gi|110825982 hect domain and RLD 5 [Homo sapiens] 80 4e-15
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 70 5e-12
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 70 5e-12
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 70 5e-12
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 3e-09
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 60 4e-09
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 60 4e-09
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 915 bits (2366), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 874 bits (2258), Expect = 0.0
Identities = 438/452 (96%), Positives = 438/452 (96%), Gaps = 14/452 (3%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQ VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQ--------------VSHRS 46
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 47 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 106
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 107 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 167 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 226
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 227 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 287 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 346
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 347 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 407 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 438
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 834 bits (2155), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 30 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 834 bits (2155), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 30 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 834 bits (2155), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 30 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 834 bits (2155), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%), Gaps = 31/452 (6%)
Query: 1 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 60
MSPKRIAKRRSPPADAIPKSKKVK VSHRS
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS 29
Query: 61 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY
Sbjct: 30 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 181 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 209
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY
Sbjct: 210 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG
Sbjct: 270 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329
Query: 361 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 420
EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV
Sbjct: 330 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Query: 421 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Sbjct: 390 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 142 bits (358), Expect = 6e-34
Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)
Query: 68 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 123
+L G GQLGLG E V+E +K I + V G HTV + G VY+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 124 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 182
CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G
Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 183 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
+GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
+ Q L+ LL + F G +F ++ G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 361 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 417
+ E + P + L V+ +ACG A V GR++++G+G N QLGTG +
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 418 SPVEMMG 424
SP + G
Sbjct: 337 SPFTVKG 343
Score = 120 bits (300), Expect = 3e-27
Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 115
H + G V T G D+GQLG + RKKP V +++V G HT+ L+
Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101
Query: 116 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 174
GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+ VF W
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 175 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 232
G ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G +
Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 233 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 292
GQLG E VP +LKS S+ V CG T A++ EG V
Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263
Query: 293 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 352
+ FG Y QLG T P+ + S + + G QH + + S G+ YS G
Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322
Query: 353 EYGRLGLGEGAEEKS 367
G+LG G + KS
Sbjct: 323 GNGQLGTGSTSNRKS 337
Score = 104 bits (259), Expect = 2e-22
Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)
Query: 186 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 245
+LEP K ++ V V G H V + DG +YT GC + GQLG
Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69
Query: 246 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 299
KSR V DA CG T A++ +G VY +GL +
Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 300 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 358
QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 359 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 416
LG ++++ P L+ L + VA G + + +T G +F WG QLG + D
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 417 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 448
+ P + K L ++ ++ + G HT L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 142 bits (358), Expect = 6e-34
Identities = 113/367 (30%), Positives = 177/367 (48%), Gaps = 34/367 (9%)
Query: 68 VLTLGQGDVGQLGLG----ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 123
+L G GQLGLG E V+E +K I + V G HTV + G VY+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF-INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 124 CNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 182
CND G LG + S + E V V L + +V VS G++HT AL D G+V+ WG D++G
Sbjct: 60 CNDLGQLGHEKSRKKPEQV---VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 183 VIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
+GL+ + VP ++ D+ +V+VA G H + L+ +++ G + GQLG +
Sbjct: 115 QLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD 174
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
+ Q L+ LL + F G +F ++ G ++G+G + +
Sbjct: 175 C-KKQTSPQLLKSLL--------------GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 301 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 360
QLG ++P L S + ++ V G+ HT + EG ++ G YG+LG
Sbjct: 220 GQLGLNDENDRYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 361 EGAEEKSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAW 417
+ E + P + L V+ +ACG A V GR++++G+G N QLGTG +
Sbjct: 278 STSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 418 SPVEMMG 424
SP + G
Sbjct: 337 SPFTVKG 343
Score = 120 bits (300), Expect = 3e-27
Identities = 100/315 (31%), Positives = 146/315 (46%), Gaps = 27/315 (8%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 115
H + G V T G D+GQLG + RKKP V +++V G HT+ L+
Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101
Query: 116 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLW 174
GQVY++G + +G LG S E + L + ++VQV+ G H+ AL+ VF W
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 175 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 232
G ++ G +GL KK P ++ L +P ++VA+G H +LT G ++ G +
Sbjct: 162 G--QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 233 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 292
GQLG E VP +LKS S+ V CG T A++ EG V
Sbjct: 220 GQLGLNDE-----------NDRYVPN--LLKSLRSQKIVYI---CCGEDHTAALTKEGGV 263
Query: 293 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 352
+ FG Y QLG T P+ + S + + G QH + + S G+ YS G
Sbjct: 264 FTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA-CGRQHTSAFVPSSGRIYSFGLG 322
Query: 353 EYGRLGLGEGAEEKS 367
G+LG G + KS
Sbjct: 323 GNGQLGTGSTSNRKS 337
Score = 104 bits (259), Expect = 2e-22
Identities = 77/272 (28%), Positives = 121/272 (44%), Gaps = 42/272 (15%)
Query: 186 LLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR 245
+LEP K ++ V V G H V + DG +YT GC + GQLG
Sbjct: 22 VLEPRKSDFF-----INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE------- 69
Query: 246 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDA------FCGAYFTFAISHEGHVYGFGLSN 299
KSR V DA CG T A++ +G VY +GL +
Sbjct: 70 -----------------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 300 YHQLGTPGTESCF-IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 358
QLG G+E C +P+N+ S S V + G +H++ + + + G+ +YG+LG
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 359 LGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 416
LG ++++ P L+ L + VA G + + +T G +F WG QLG + D
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 417 WSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 448
+ P + K L ++ ++ + G HT L K+
Sbjct: 231 YVP--NLLKSLRSQKIVYICCGEDHTAALTKE 260
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 136 bits (342), Expect = 4e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 116
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 117 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 175
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 176 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 235
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
Query: 236 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 295
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
Query: 296 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 353
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
Query: 354 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 384
+G+LGLG E IPTL S V VACG
Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
Score = 87.0 bits (214), Expect = 3e-17
Identities = 85/290 (29%), Positives = 134/290 (46%), Gaps = 31/290 (10%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQAEAGGMHTVCL 113
+H STE G V G + GQLGLG+ ER ++S + Q AG + L
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 114 SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFL 173
++ G+++ +G N EG +G + VP +V + + V +S G H+A +T DG +++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 174 WGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTADGDLYTLGCGE 231
+G NG +GL + + Q+ ++P V++VA G +H V+LT + +YT G G+
Sbjct: 214 FG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQ 270
Query: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291
GQLG LF PK + + ++ CG T I+ G
Sbjct: 271 FGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGENHTALITDIGL 315
Query: 292 VYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHTV 338
+Y FG + +LG G E+ FIP ++F V GG H V
Sbjct: 316 MYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMVV 363
Score = 75.9 bits (185), Expect = 7e-14
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 165 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 222
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
Query: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 281
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
Query: 282 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
Query: 340 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 399
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 400 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 448
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 136 bits (342), Expect = 4e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 116
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 117 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 175
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 176 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 235
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
Query: 236 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 295
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
Query: 296 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 353
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
Query: 354 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 384
+G+LGLG E IPTL S V VACG
Sbjct: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
Score = 87.0 bits (214), Expect = 3e-17
Identities = 85/290 (29%), Positives = 134/290 (46%), Gaps = 31/290 (10%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI---PEDVVQAEAGGMHTVCL 113
+H STE G V G + GQLGLG+ ER ++S + Q AG + L
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 114 SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFL 173
++ G+++ +G N EG +G + VP +V + + V +S G H+A +T DG +++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKN--VSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 174 WGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP--VVKVASGNDHLVMLTADGDLYTLGCGE 231
+G NG +GL + + Q+ ++P V++VA G +H V+LT + +YT G G+
Sbjct: 214 FG--EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQ 270
Query: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291
GQLG LF PK + + ++ CG T I+ G
Sbjct: 271 FGQLGLGTFLFETS----------EPKVIENIRDQTISYIS-----CGENHTALITDIGL 315
Query: 292 VYGFGLSNYHQLGTPGTESC---FIPQNLTSFKNSTKSWVGFSGGQHHTV 338
+Y FG + +LG G E+ FIP ++F V GG H V
Sbjct: 316 MYTFGDGRHGKLGL-GLENFTNHFIPTLCSNFLRFIVKLVA-CGGCHMVV 363
Score = 75.9 bits (185), Expect = 7e-14
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 165 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 222
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
Query: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 281
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
Query: 282 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
Query: 340 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 399
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 400 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 448
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 132 bits (332), Expect = 6e-31
Identities = 113/404 (27%), Positives = 184/404 (45%), Gaps = 43/404 (10%)
Query: 68 VLTLGQGDVGQLGLGEN----VMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFG 123
+L G +GQ G+ N V E + +S V + GG H+V L + G+VY+ G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFIS-DRSVKEVACGGNHSVFLLEDGEVYTCG 59
Query: 124 CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 183
N +G LG + E + + + ++ V+ G+SH+ AL+D G++F WG+ D G
Sbjct: 60 LNTKGQLGHEREGNKPEQIGALAD--QHIIHVACGESHSLALSDRGQLFSWGAGSD--GQ 115
Query: 184 IGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPEL 241
+GL+ VP +Q +++V+ GN H + L ADG +T G GQLG E
Sbjct: 116 LGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE- 174
Query: 242 FANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYH 301
F ++ Q + R G Q A GA+ +FA+S G V+G+G++N
Sbjct: 175 FPSQASPQ-------------RVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWGMNNAG 220
Query: 302 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 361
QLG + P ++ + T+ V S G+ HT + G ++ G G+LG
Sbjct: 221 QLGLSDEKDRESPCHVKLLR--TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278
Query: 362 GAEEKSIPTLISRLPA-VSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSP 419
+E + ++ + + V+ +ACG A V G ++A+G G QLGTG + P
Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338
Query: 420 VEMMG-------------KQLENRVVLSVSSGGQHTVLLVKDKE 450
+ G + + +V + SGG T +L E
Sbjct: 339 SPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYE 382
Score = 106 bits (264), Expect = 5e-23
Identities = 89/316 (28%), Positives = 138/316 (43%), Gaps = 29/316 (9%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLS 114
+H E G V T G GQLG + E KP + D ++ G H++ LS
Sbjct: 44 NHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGALADQHIIHVACGESHSLALS 100
Query: 115 KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVF 172
GQ++S+G +G LG T+ E S VP ++ Q+ ++QVS G+ H AL DG+ F
Sbjct: 101 DRGQLFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 159
Query: 173 LWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCG 230
WG ++++G +GL + P +V+ +P+ +VA+G H L+ G ++ G
Sbjct: 160 TWG--KNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMN 217
Query: 231 EQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEG 290
GQLG E +R ++ L K V + CG T ++ G
Sbjct: 218 NAGQLGLSDE--KDRESPCHVKLLRTQKVVYIS--------------CGEEHTAVLTKSG 261
Query: 291 HVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLG 350
V+ FG + QLG P+ + S + + G QH + S G Y+ G
Sbjct: 262 GVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA-CGRQHTLAFVPSSGLIYAFG 320
Query: 351 RAEYGRLGLGEGAEEK 366
G+LG G K
Sbjct: 321 CGARGQLGTGHTCNVK 336
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 124 bits (311), Expect = 2e-28
Identities = 93/303 (30%), Positives = 144/303 (47%), Gaps = 30/303 (9%)
Query: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 211
V Q++ + L+ +GRV+ D L P VQ +VK+A+
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDT------LAPQL-----VQGLASRNIVKIAAH 501
Query: 212 ND--HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 269
+D H + L A G++Y+ GCG+ G+LG G LE PK + S G +
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH--------GDTVPLEE---PKVISAFS-GKQA 549
Query: 270 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 329
CG+ ++ AI+ EG +Y +G NY +LG +E IP + K V
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
Query: 330 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASV 387
G T+ + G+ +S G +YG+LG G G++ P LI +L V V CG+
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRG-GSDGCKTPKLIEKLQDLDVVKVRCGSQF 668
Query: 388 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 447
A+TKDG+V++WG G N +LG G +E P + G L+ + V+ V++G H + L +
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--LQGKKVIDVAAGSTHCLALTE 726
Query: 448 DKE 450
D E
Sbjct: 727 DSE 729
Score = 122 bits (307), Expect = 5e-28
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 28/347 (8%)
Query: 110 TVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM---VPGKVELQEKVVQVSAGDSHTAALT 166
T+ SG +Y +G N G LG +EG+++ P + + VQ+ G+ A+T
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
Query: 167 DDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-LDVPVVKVASGNDHLVMLTADGDLY 225
DG+++ G IG E + + +Q + + V V SG H + L+++G++Y
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
Query: 226 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 285
+ G E G+LG G R +R P+ + RG + D G +
Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDR---PRVI----ESLRG-IEVVDVAAGGAHSAC 4105
Query: 286 ISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK 345
++ G +Y +G Y +LG +E P+ + + + + G T+C+ +
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 346 AYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMG 403
+S G +YG+LG G G++ +P I L V V CG+ A+TK G V+ WG G
Sbjct: 4166 VWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224
Query: 404 TNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 450
++LG G D+ P ++ G L+ + V+++++G H V +D E
Sbjct: 4225 DYHRLGHGSDDHVRRPRQVQG--LQGKKVIAIATGSLHCVCCTEDGE 4269
Score = 120 bits (302), Expect = 2e-27
Identities = 104/364 (28%), Positives = 170/364 (46%), Gaps = 41/364 (11%)
Query: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEM-VPGKVELQE--KVVQVS 156
+++ +A G+ + ++ +V+ +G ND+ LG ++GS++ VP E VVQV+
Sbjct: 2943 LIRKKAAGLESAATIRT-KVFVWGLNDKDQLG---GLKGSKIKVPSFSETLSALNVVQVA 2998
Query: 157 AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD------VPVVKVAS 210
G A+T +G+V+ G NG +GL + VP+ Q+ V V V S
Sbjct: 2999 GGSKSLFAVTVEGKVYACGEA--TNGRLGL--GISSGTVPIPRQITALSSYVVKKVAVHS 3054
Query: 211 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCV-MLKSRGSRG 269
G H LT DG +++ G G+ G+LG + ++ P+ + LK++
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-----------PRLIEALKTK---- 3099
Query: 270 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 329
R +D CG+ + A++ G +Y +GL Y +LG + P+ + V
Sbjct: 3100 --RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVA 3157
Query: 330 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASV 387
T+ + EG +S G ++G+LG G G+E +IP I RL V + CGA
Sbjct: 3158 CGSRDAQTLALTDEGLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQF 3216
Query: 388 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 447
A+TK G V+ WG G ++LG G D P + G L + ++ V+ G H L V
Sbjct: 3217 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG--LRGKKIVHVAVGALH-CLAVT 3273
Query: 448 DKEQ 451
D Q
Sbjct: 3274 DSGQ 3277
Score = 120 bits (301), Expect = 3e-27
Identities = 115/387 (29%), Positives = 168/387 (43%), Gaps = 36/387 (9%)
Query: 68 VLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLSKSGQVYSFGCN 125
V G D QLG G + K P+ +VVQ G ++ G+VY+ G
Sbjct: 2961 VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019
Query: 126 DEGALGRDTSVEGSEMVPGKVELQE----KVVQVSAGDSHTAALTDDGRVFLWGSFRDNN 181
G LG S G+ +P ++ K V V +G H ALT DG+VF WG D
Sbjct: 3020 TNGRLGLGIS-SGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD-- 3076
Query: 182 GVIGLLEPMKKSMVPVQVQLDVPVVK-VASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 240
G +G M + L ++ +A G+ H LT+ G+LYT G GE G+LG
Sbjct: 3077 GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN 3136
Query: 241 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF--TFAISHEGHVYGFGLS 298
L PK V + GH Q A CG+ T A++ EG V+ +G
Sbjct: 3137 TTQ-----------LKPKMVKVLL----GHRVIQVA-CGSRDAQTLALTDEGLVFSWGDG 3180
Query: 299 NYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 358
++ +LG G+E C IPQN+ + G ++ + G ++ G+ +Y RLG
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
Query: 359 LGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 416
G + P ++ L + VA GA AVT G+V+AWG + Q G G
Sbjct: 3239 HGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3297
Query: 417 WSPVEMMGKQLENRVVLSVSSGGQHTV 443
P + G LE + + V+ G H+V
Sbjct: 3298 RKPTLVQG--LEGQKITRVACGSSHSV 3322
Score = 114 bits (284), Expect = 2e-25
Identities = 110/398 (27%), Positives = 162/398 (40%), Gaps = 37/398 (9%)
Query: 66 GLVLTLGQGDVGQLGLGENVMER-KKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGC 124
G + G GQLG E + P VQ G ++ G++Y+ G
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011
Query: 125 NDEGALGRDTSVEGSEMVPGKVELQE------KVVQVSAGDSHTAALTDDGRVFLWGSFR 178
G LG + G+E V L+ K V V++G H AL+ +G V+ WG
Sbjct: 4012 GAGGRLG----IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
Query: 179 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRV 238
D G P + V ++ + VV VA+G H +TA GDLYT G G G+LG
Sbjct: 4068 DGKLGHGNRSPCDRPRV-IESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126
Query: 239 PELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA--YFTFAISHEGHVYGFG 296
E L PK V +GH R D CG+ T ++ + V+ +G
Sbjct: 4127 DS-----------EDQLKPKLV----EALQGH-RVVDIACGSGDAQTLCLTDDDTVWSWG 4170
Query: 297 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 356
+Y +LG G++ C +P + S V G +V + G Y+ G+ +Y R
Sbjct: 4171 DGDYGKLGRGGSDGCKVPMKIDSLTGL--GVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228
Query: 357 LGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE 414
LG G + P + L V ++A G+ T+DG V+ WG QLG G
Sbjct: 4229 LGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287
Query: 415 DAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 452
P + L+ + V V+ G HT+ K S
Sbjct: 4288 AIQRP--RLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323
Score = 108 bits (270), Expect = 1e-23
Identities = 95/332 (28%), Positives = 152/332 (45%), Gaps = 29/332 (8%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEA---GGMHTVCLSKSGQV 119
T G + G G G+LG+G L SI ++ A GG H + LS G+V
Sbjct: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060
Query: 120 YSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLWGSF 177
YS+G ++G LG P +E +VV V+AG +H+A +T G ++ WG
Sbjct: 4061 YSWGEAEDGKLGHGNRSPCDR--PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4118
Query: 178 RDNN-GVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236
R G + +K +V V + SG+ + LT D +++ G G+ G+LG
Sbjct: 4119 RYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4178
Query: 237 RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 296
RGG G + VP + + S G V+ + CG+ F+ A++ G VY +G
Sbjct: 4179 --------RGGSDGCK---VP--MKIDSLTGLGVVKVE---CGSQFSVALTKSGAVYTWG 4222
Query: 297 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 356
+YH+LG + P+ + + K + + G H VC +G+ Y+ G + G+
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQG--KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280
Query: 357 LGLGEGAEEKSIPTLISRLPA--VSSVACGAS 386
LG G P L++ L V+ VACG++
Sbjct: 4281 LGDGT-TNAIQRPRLVAALQGKKVNRVACGSA 4311
Score = 103 bits (257), Expect = 3e-22
Identities = 94/342 (27%), Positives = 157/342 (45%), Gaps = 36/342 (10%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENV----MERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 118
T G V G+ G+LGLG + + R+ AL S V +GG H L+ G+
Sbjct: 3008 TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK 3067
Query: 119 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFR 178
V+S+G D+G LG + + + + +++ ++ G SH+AALT G ++ WG
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGL-- 3125
Query: 179 DNNGVIGLL------EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 232
G G L +K MV V + V V S + + LT +G +++ G G+
Sbjct: 3126 ---GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182
Query: 233 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 292
G+LG RGG +G +P+ ++ +G + + CGA F+ A++ G V
Sbjct: 3183 GKLG--------RGGSEGCN---IPQ--NIERLNGQGVCQIE---CGAQFSLALTKSGVV 3226
Query: 293 YGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRA 352
+ +G +Y +LG PQ + + K V + G H + + G+ Y+ G
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRG--KKIVHVAVGALHCLAVTDSGQVYAWGDN 3284
Query: 353 EYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVT 392
++G+ G G + PTL+ L ++ VACG+S A T
Sbjct: 3285 DHGQQGNGTTTVNRK-PTLVQGLEGQKITRVACGSSHSVAWT 3325
Score = 89.7 bits (221), Expect = 5e-18
Identities = 82/322 (25%), Positives = 148/322 (45%), Gaps = 47/322 (14%)
Query: 101 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE-----MVPGKVELQEKVVQV 155
+ A + G H + L+ +G+VYS+GC D G LG +V E GK + + VV +
Sbjct: 498 IAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGK-QAGKHVVHI 556
Query: 156 SAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ----LDVPVVKVASG 211
+ G +++AA+T +G ++ WG R N G +G + +P+ V L V V SG
Sbjct: 557 ACGSTYSAAITAEGELYTWG--RGNYGRLG-HGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 212 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 271
+ + +T +G +++ G G+ G+LG RGG G + PK + V
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLG--------RGGSDGCK---TPKLIEKLQDLDVVKV 662
Query: 272 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 331
R CG+ F+ A++ +G VY +G + +LG E P+ L + K + +
Sbjct: 663 R-----CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQG--KKVIDVA 715
Query: 332 GGQHHTVCMDSEGKAYSLGRAE----YGRLGLGEGAEEKSIPTLISRLPAVSSVACGASV 387
G H + + + + +S G + + L + + E ++P L ++ + +ACG +
Sbjct: 716 AGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK-PEPAALPGLDTK--HIVGIACGPA- 771
Query: 388 GYAVTKDGRVFAWGMGTNYQLG 409
+ FAW + + +G
Sbjct: 772 --------QSFAWSSCSEWSIG 785
Score = 79.0 bits (193), Expect = 8e-15
Identities = 67/239 (28%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 212 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 271
+D + G +Y G +GQLG G +G + + C L + +
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG----------GIEGAKVKVPTPCEALAT------L 3985
Query: 272 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 331
R G FA++ +G +Y G +LG GTES P L S ++ V +
Sbjct: 3986 RPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVN 4045
Query: 332 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGY 389
G H + + SEG+ YS G AE G+LG G P +I L + VA G +
Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIESLRGIEVVDVAAGGAHSA 4104
Query: 390 AVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 448
VT G ++ WG G +LG ED P + Q V ++ SG T+ L D
Sbjct: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163
Score = 75.5 bits (184), Expect = 9e-14
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 30/259 (11%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 115
H + T G V + G+GD G+LG M KP L+ + + G H+ L+
Sbjct: 3058 HATALTVDGKVFSWGEGDDGKLGHFSR-MNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
Query: 116 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAG--DSHTAALTDDGRVFL 173
SG++Y++G + G LG + + KV L +V+QV+ G D+ T ALTD+G VF
Sbjct: 3117 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 3176
Query: 174 WGSFRDNNGVIGLL--EPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGC 229
WG +G G L + +P ++ V ++ G + LT G ++T G
Sbjct: 3177 WG-----DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Query: 230 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 289
G+ +LG ++ + P+ V G RG + GA A++
Sbjct: 3232 GDYFRLGHGSDVHVRK-----------PQVV----EGLRGK-KIVHVAVGALHCLAVTDS 3275
Query: 290 GHVYGFGLSNYHQLGTPGT 308
G VY +G +++ Q G T
Sbjct: 3276 GQVYAWGDNDHGQQGNGTT 3294
Score = 75.5 bits (184), Expect = 9e-14
Identities = 80/296 (27%), Positives = 132/296 (44%), Gaps = 37/296 (12%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPE-DVVQAEAGGMHTVCLSKSGQVYSFGC 124
G V + G+ + G+LG G + + S+ +VV AGG H+ C++ +G +Y++G
Sbjct: 4058 GEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGK 4117
Query: 125 NDEGALGRDTSVEGSEMVPGKVELQE--KVVQVS--AGDSHTAALTDDGRVFLWG----S 176
G LG S + ++ P VE + +VV ++ +GD+ T LTDD V+ WG
Sbjct: 4118 GRYGRLGHSDSED--QLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYG 4175
Query: 177 FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236
G G PMK + + VVKV G+ V LT G +YT G G+ +LG
Sbjct: 4176 KLGRGGSDGCKVPMK-----IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
Query: 237 RVPELFANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 295
+ R + QGL+ K + + + G+ + +G VY +
Sbjct: 4231 HGSDDHVRRPRQVQGLQG---KKVIAIAT--------------GSLHCVCCTEDGEVYTW 4273
Query: 296 GLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
G ++ QLG T + P+ + + + + V + G HT+ S K S G+
Sbjct: 4274 GDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV--ACGSAHTLAW-STSKPASAGK 4326
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/188 (32%), Positives = 97/188 (51%), Gaps = 14/188 (7%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGMHTVC 112
+H + T G + T G+G G+LG ++ ++ KP LV + + +G T+C
Sbjct: 4101 AHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
Query: 113 LSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGR 170
L+ V+S+G D G LGR S +G + VP K++ VV+V G + ALT G
Sbjct: 4160 LTDDDTVWSWGDGDYGKLGRGGS-DGCK-VPMKIDSLTGLGVVKVECGSQFSVALTKSGA 4217
Query: 171 VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVPVVKVASGNDHLVMLTADGDLYTLG 228
V+ WG + G + +++ P QVQ V+ +A+G+ H V T DG++YT G
Sbjct: 4218 VYTWGKGDYHRLGHGSDDHVRR---PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
Query: 229 CGEQGQLG 236
++GQLG
Sbjct: 4275 DNDEGQLG 4282
Score = 69.7 bits (169), Expect = 5e-12
Identities = 55/146 (37%), Positives = 75/146 (51%), Gaps = 17/146 (11%)
Query: 36 GARSCQGACGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS 95
G + ACG D +T V TE G V + G GD G+LG G + K P L+
Sbjct: 602 GLKVIDVACGSG--DAQTLAV------TENGQVWSWGDGDYGKLGRGGSD-GCKTPKLIE 652
Query: 96 IPED--VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTS--VEGSEMVPGKVELQ-E 150
+D VV+ G ++ L+K GQVYS+G D LG T V +++ G LQ +
Sbjct: 653 KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG---LQGK 709
Query: 151 KVVQVSAGDSHTAALTDDGRVFLWGS 176
KV+ V+AG +H ALT+D V WGS
Sbjct: 710 KVIDVAAGSTHCLALTEDSEVHSWGS 735
Score = 68.9 bits (167), Expect = 9e-12
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 8/177 (4%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV----VQAEAGGMHTVCLSKSGQ 118
T G + T G+G+ G+LG G + + P LV+ + + V +G T+ ++++GQ
Sbjct: 567 TAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ 625
Query: 119 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQE-KVVQVSAGDSHTAALTDDGRVFLWGSF 177
V+S+G D G LGR S +G + +LQ+ VV+V G + ALT DG+V+ WG
Sbjct: 626 VWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG 684
Query: 178 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 234
+ G E ++ + +Q V+ VA+G+ H + LT D ++++ G +Q Q
Sbjct: 685 DNQRLGHGTEEHVRYPKLLEGLQ-GKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 68.9 bits (167), Expect = 9e-12
Identities = 61/189 (32%), Positives = 89/189 (47%), Gaps = 16/189 (8%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERK-KPALVSIPEDVVQAEAGG--MHTVCL 113
SH + T G + T G G+ G+LG G+N + K K V + V+Q G T+ L
Sbjct: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLAL 3168
Query: 114 SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRV 171
+ G V+S+G D G LGR S EG +P +E + V Q+ G + ALT G V
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGS-EGCN-IPQNIERLNGQGVCQIECGAQFSLALTKSGVV 3226
Query: 172 FLWGS---FRDNNGV-IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTL 227
+ WG FR +G + + +P V+ +V VA G H + +T G +Y
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQ-----VVEGLRGKKIVHVAVGALHCLAVTDSGQVYAW 3281
Query: 228 GCGEQGQLG 236
G + GQ G
Sbjct: 3282 GDNDHGQQG 3290
Score = 57.0 bits (136), Expect = 3e-08
Identities = 37/106 (34%), Positives = 60/106 (56%), Gaps = 7/106 (6%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 121
T+ G V T G+GD +LG G + R+ + + + V+ G +H VC ++ G+VY+
Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYT 4272
Query: 122 FGCNDEGALGRDT--SVEGSEMVPGKVELQ-EKVVQVSAGDSHTAA 164
+G NDEG LG T +++ +V LQ +KV +V+ G +HT A
Sbjct: 4273 WGDNDEGQLGDGTTNAIQRPRLV---AALQGKKVNRVACGSAHTLA 4315
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 109 bits (273), Expect = 4e-24
Identities = 108/386 (27%), Positives = 172/386 (44%), Gaps = 73/386 (18%)
Query: 102 QAEAGGMHTVCLSKSGQVYSF-----GCNDEGALGRDTSVEGSEMVPGKVE-LQEKVV-Q 154
Q AG H ++ ++Y++ G G LG + S P VE LQ K + Q
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGD--KASYRQPKHVEKLQGKAIRQ 430
Query: 155 VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGL--------LEPMKKSMVPVQVQLDVPVV 206
VS GD T +TD+G+++ +GS D G +G+ LEPM+ + L PV
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGS--DYYGCMGVDKVAGPEVLEPMQLNFF-----LSNPVE 483
Query: 207 KVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRG 266
+V+ G++H+V+LT + ++Y+ GCGE G+LG + +++ VPK +++ +
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLG-----LDSEEDYYTPQKVDVPKALIIVA-- 536
Query: 267 SRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLG----------------TPGTES 310
CG TF ++ G V GL+ +++LG P T S
Sbjct: 537 ---------VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS 587
Query: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370
+ + L+ +K T + G+ HT +D G+ + G + G+LG+G + I
Sbjct: 588 FTLAKQLSFYKIRT-----IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINL 642
Query: 371 LISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT-------GQDEDAWSPVE 421
L L V V+CG A T D +FAWG G N +L G D P
Sbjct: 643 LGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRP 702
Query: 422 MMGKQLENRVVLSVSSGGQHTVLLVK 447
+ G V +S G HT+L+V+
Sbjct: 703 IFGSL---HHVPDLSCRGWHTILIVE 725
Score = 68.2 bits (165), Expect = 1e-11
Identities = 69/265 (26%), Positives = 105/265 (39%), Gaps = 36/265 (13%)
Query: 63 TEPGLVLTLGQGDVGQLGL----GENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 118
T+ G + G G +G+ G V+E + + V Q G H V L+++ +
Sbjct: 442 TDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-LSNPVEQVSCGDNHVVVLTRNKE 500
Query: 119 VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLWG- 175
VYS+GC + G LG D+ E P KV++ + +V V G T LT G+V G
Sbjct: 501 VYSWGCGEYGRLGLDS--EEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGL 558
Query: 176 ----SFRDNNGVIGLLEPMKKSMVPVQVQLDV-------PVVKVASGNDHLVMLTADGDL 224
N + G++ VP + + +A G H + G L
Sbjct: 559 NEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRL 618
Query: 225 YTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTF 284
T GC + GQLG N R G+ L P G + +R CG FT
Sbjct: 619 LTFGCNKCGQLG-----VGNYKKRLGINLLGGP-------LGGKQVIRVS---CGDEFTI 663
Query: 285 AISHEGHVYGFGLSNYHQLGTPGTE 309
A + + H++ +G +L TE
Sbjct: 664 AATDDNHIFAWGNGGNGRLAMTPTE 688
Score = 40.8 bits (94), Expect = 0.003
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 15/147 (10%)
Query: 314 PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL-----GRAEYGRLGLGEGAEEKSI 368
PQ L K+ + +G H V + E + Y+ G +G+LG G+ A +
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAV-VTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ- 416
Query: 369 PTLISRLP--AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 426
P + +L A+ V+CG VT +G+++A+G ++Y G D+ A P + Q
Sbjct: 417 PKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFG--SDYYGCMGVDKVA-GPEVLEPMQ 473
Query: 427 LE---NRVVLSVSSGGQHTVLLVKDKE 450
L + V VS G H V+L ++KE
Sbjct: 474 LNFFLSNPVEQVSCGDNHVVVLTRNKE 500
Score = 31.6 bits (70), Expect = 1.5
Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 4/77 (5%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGGMHTVCL 113
+H + E G +LT G GQLG+G N +R L+ P + V++ G T+
Sbjct: 607 THTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAA 665
Query: 114 SKSGQVYSFGCNDEGAL 130
+ ++++G G L
Sbjct: 666 TDDNHIFAWGNGGNGRL 682
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 81 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 137
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
Query: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
Query: 198 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 255
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Query: 256 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 308
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 309 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 368
+ +P+ + F + G + + G + G R E
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
Query: 369 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 425
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
Query: 426 QLENRVVLSVSSGGQHTVLLVKDKEQS 452
L+ V+ G H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 115
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 116 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 151
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
Query: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 201
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 81 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 137
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
Query: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
Query: 198 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 255
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Query: 256 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 308
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 309 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 368
+ +P+ + F + G + + G + G R E
Sbjct: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
Query: 369 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 425
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
Query: 426 QLENRVVLSVSSGGQHTVLLVKDKEQS 452
L+ V+ G H++++ +D+ ++
Sbjct: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 115
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 116 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 151
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
Query: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 201
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 100 bits (248), Expect = 4e-21
Identities = 90/318 (28%), Positives = 148/318 (46%), Gaps = 31/318 (9%)
Query: 66 GLVLTLGQGDVGQLGLGE----NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYS 121
G VL G+G G+LG G +V+ + +V + H++ L++SG+V+S
Sbjct: 4046 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105
Query: 122 FGCNDEGALGRDTSVEGSEMVPGKVE-LQ-EKVVQVSAGDSHTAALTDDGRVFLWGSFRD 179
+G D G LG S + P ++E LQ E+VVQ+S G H+A +T DG++F +G+
Sbjct: 4106 WGDGDYGKLGHGNS--DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--G 4161
Query: 180 NNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL-YTLGCGEQGQLGR 237
+ G +GL K + L+ + +VA G +H + ++ADG + + G G+ G+LG
Sbjct: 4162 DYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG- 4220
Query: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
N + +++ V + +K CG F+ A++ +GHVY FG
Sbjct: 4221 ----LGNSTAKSSPQKIDVLCGIGIKK-----------VACGTQFSVALTKDGHVYTFGQ 4265
Query: 298 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 357
L + PQ + V G HT+ + S G Y+ G G+L
Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV--GAEHTLALASNGDVYAWGSNSEGQL 4323
Query: 358 GLGEGAEEKSIPTLISRL 375
GLG + PTL++ L
Sbjct: 4324 GLGHTNHVRE-PTLVTGL 4340
Score = 95.1 bits (235), Expect = 1e-19
Identities = 93/348 (26%), Positives = 160/348 (45%), Gaps = 37/348 (10%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP----EDVVQAEAGGMHTVCLSKSGQVYS 121
G V G+G G+LGLG++ + L P + V ++ HT+ + G+V+S
Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
Query: 122 FGCNDEGALGRDTSVEGSEMVPGKVE--LQEKVVQ-VSAGDSHTAALTDDGRVFLWGSFR 178
+G D G LG S ++ P ++ LQ KVV VSAG H+AA+T+DG ++ WG
Sbjct: 482 WGDGDYGKLGHGNS--STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWG--E 537
Query: 179 DNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG-DLYTLGCGEQGQLGR 237
+ G +G + ++ +P V+ V +V+ G+ H + L+ DG +++ G G+ G+L
Sbjct: 538 GDFGRLGHGDSNSRN-IPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKL-- 594
Query: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
G R+ PK + +G + + G+ + A++ G VY +G
Sbjct: 595 ---------GHGDTNRVYKPKVI----EALQG-MFIRKVCAGSQSSLALTSTGQVYAWGC 640
Query: 298 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 357
LG +E+ + L +T+ V S G H + + + + Y+ G G+
Sbjct: 641 GAC--LGCGSSEATALRPKLIEELAATRI-VDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697
Query: 358 GLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVT---KDGRVFAW 400
G G + P +S L A+ ++ G S A T +D +V AW
Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745
Score = 94.4 bits (233), Expect = 2e-19
Identities = 83/284 (29%), Positives = 132/284 (46%), Gaps = 25/284 (8%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKS 116
H TE G V + G GD G+LG G + +R+ + ++ E+VVQ G H+ ++
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152
Query: 117 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLW 174
G++++FG D G LG + ++ +P +V E ++ QV+ G +HT A++ DG + +W
Sbjct: 4153 GKLFTFGNGDYGRLGLGNT--SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSM-VW 4209
Query: 175 GSFRDNNGVIGL-LEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 233
+ G +GL K S + V + + KVA G V LT DG +YT G Q
Sbjct: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG---QD 4266
Query: 234 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 293
+L +PE A R +L V +D GA T A++ G VY
Sbjct: 4267 RLIGLPEGRARNHNRPQQIPVL-------------AGVIIEDVAVGAEHTLALASNGDVY 4313
Query: 294 GFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 337
+G ++ QLG T P +T + K+ S G+ H+
Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQG--KNVRQISAGRCHS 4355
Score = 94.0 bits (232), Expect = 3e-19
Identities = 109/383 (28%), Positives = 163/383 (42%), Gaps = 42/383 (10%)
Query: 72 GQGDVGQLG-LGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGAL 130
G G GQL G NVM PA Q G T + +G V + G G L
Sbjct: 4003 GAGRHGQLAEAGRNVMV---PAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059
Query: 131 GRDTSVEGSEM-----VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG 185
G+ S + + + G V Q +V D H+ ALT+ G VF WG + G +G
Sbjct: 4060 GQGNSDDLHVLTVISALQGFVVTQ--LVTSCGSDGHSMALTESGEVFSWGD--GDYGKLG 4115
Query: 186 LLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFA 243
++ P Q++ VV+++ G H ++T+DG L+T G G+ G+LG
Sbjct: 4116 HGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG-----LG 4169
Query: 244 NRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQ 302
N ++ ER+ + + G V CG T A+S +G V+ FG +Y +
Sbjct: 4170 NTSNKKLPERVTALEGYQI------GQVA-----CGLNHTLAVSADGSMVWAFGDGDYGK 4218
Query: 303 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEG 362
LG + + PQ + V G +V + +G Y+ G+ +GL EG
Sbjct: 4219 LGLGNSTAKSSPQKIDVLCGIGIKKVAC--GTQFSVALTKDGHVYTFGQDRL--IGLPEG 4274
Query: 363 -AEEKSIPTLISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 419
A + P I L V VA GA A+ +G V+AWG + QLG G P
Sbjct: 4275 RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREP 4334
Query: 420 VEMMGKQLENRVVLSVSSGGQHT 442
+ G Q +N V +S+G H+
Sbjct: 4335 TLVTGLQGKN--VRQISAGRCHS 4355
Score = 92.0 bits (227), Expect = 1e-18
Identities = 99/364 (27%), Positives = 153/364 (42%), Gaps = 37/364 (10%)
Query: 90 KPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 149
+P L D EAG T +S G V + G G LG S S + E
Sbjct: 395 QPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPH 454
Query: 150 EKVVQVSAG---DSHTAALTDDGRVFLWGSF---RDNNGVIGLLEPMKKSMVPVQVQLDV 203
+ +VS+ D HT A T +G VF WG + +G + K P+Q ++
Sbjct: 455 RSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKV-- 512
Query: 204 PVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLK 263
VV V++G H +T DG+LYT G G+ G+LG N +P ++K
Sbjct: 513 -VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRN-----------IP--TLVK 558
Query: 264 SRGSRGHVRFQDAFCGAYFTFAISHEGH-VYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 322
+ G V CG+ T A+S +G V+ FG + +LG T + P+ + + +
Sbjct: 559 DISNVGEVS-----CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613
Query: 323 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSS 380
V G ++ + S G+ Y+ G LG G P LI L A +
Sbjct: 614 MFIRKV--CAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVD 669
Query: 381 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDE-DAWSPVEMMGKQLENRVVLSVSSGG 439
V+ G S A++ D V+AWG + Q G G P ++ G L+ + +S+G
Sbjct: 670 VSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG--LDGIAIQQISAGT 727
Query: 440 QHTV 443
H++
Sbjct: 728 SHSL 731
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/252 (30%), Positives = 113/252 (44%), Gaps = 27/252 (10%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGGMHTVCLS 114
H T G V + G GD G+LG G N +K P L+ P + VV AG H+ ++
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHG-NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
Query: 115 KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLW 174
+ G++Y++G D G LG S S +P V+ V +VS G SHT AL+ DGR +W
Sbjct: 528 EDGELYTWGEGDFGRLGHGDS--NSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRT-VW 584
Query: 175 GSFRDNNGVIGLLEPMK--KSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 232
+NG +G + + K V ++ + + KV +G+ + LT+ G +Y GCG
Sbjct: 585 SFGGGDNGKLGHGDTNRVYKPKV-IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG-- 641
Query: 233 GQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHV 292
A G L PK + R D G A+SH+ V
Sbjct: 642 ----------ACLGCGSSEATALRPKLI-----EELAATRIVDVSIGDSHCLALSHDNEV 686
Query: 293 YGFGLSNYHQLG 304
Y +G ++ Q G
Sbjct: 687 YAWGNNSMGQCG 698
Score = 84.0 bits (206), Expect = 3e-16
Identities = 79/288 (27%), Positives = 127/288 (44%), Gaps = 39/288 (13%)
Query: 171 VFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCG 230
V+LWG+ R L E + MVP +V G + ++ A+G + G G
Sbjct: 3999 VYLWGAGRHGQ----LAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEG 4054
Query: 231 EQGQLGRVPELFANRGGRQGLERLLVPKCV-------MLKSRGSRGHVRFQDAFCGAYFT 283
G+LG+ G L L V + ++ S GS GH +
Sbjct: 4055 SYGRLGQ--------GNSDDLHVLTVISALQGFVVTQLVTSCGSDGH------------S 4094
Query: 284 FAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 343
A++ G V+ +G +Y +LG ++ P+ + + + + V S G H+ + S+
Sbjct: 4095 MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG--EEVVQMSCGFKHSAVVTSD 4152
Query: 344 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDG-RVFAW 400
GK ++ G +YGRLGLG K +P ++ L + VACG + AV+ DG V+A+
Sbjct: 4153 GKLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
Query: 401 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 448
G G +LG G SP ++ L + V+ G Q +V L KD
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKI--DVLCGIGIKKVACGTQFSVALTKD 4257
Score = 79.0 bits (193), Expect = 8e-15
Identities = 88/354 (24%), Positives = 154/354 (43%), Gaps = 52/354 (14%)
Query: 113 LSKSGQVYSFGCNDEGAL--GRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGR 170
+S++ +VY +G N L G + ++ P + Q + AG T ++ DG
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT----IEAGQYCTFVISTDGS 423
Query: 171 VFLWGSFRDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGND-HLVMLTADGDLYT 226
V G + + G +GL + +S + + + V + G+D H + T +G++++
Sbjct: 424 VRACG--KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
Query: 227 LGCGEQGQLG-------RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCG 279
G G+ G+LG + P+L +G QG K V+ S G R
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLI--QGPLQG-------KVVVCVSAGYR----------- 521
Query: 280 AYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339
+ A++ +G +Y +G ++ +LG + S IP + N + S G HT+
Sbjct: 522 --HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGE----VSCGSSHTIA 575
Query: 340 MDSEGKA-YSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 396
+ +G+ +S G + G+LG G+ P +I L + V G+ A+T G+
Sbjct: 576 LSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQ 634
Query: 397 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 450
V+AWG G LG G E +++ + R+V VS G H + L D E
Sbjct: 635 VYAWGCGA--CLGCGSSEATALRPKLIEELAATRIV-DVSIGDSHCLALSHDNE 685
Score = 78.6 bits (192), Expect = 1e-14
Identities = 57/185 (30%), Positives = 89/185 (48%), Gaps = 12/185 (6%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSG 117
H + TE G + T G+GD G+LG G++ R P LV +V + G HT+ LSK G
Sbjct: 522 HSAAVTEDGELYTWGEGDFGRLGHGDS-NSRNIPTLVKDISNVGEVSCGSSHTIALSKDG 580
Query: 118 Q-VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK--VVQVSAGDSHTAALTDDGRVFLW 174
+ V+SFG D G LG + P +E + + +V AG + ALT G+V+ W
Sbjct: 581 RTVWSFGGGDNGKLGHGDT--NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
Query: 175 GSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQ 232
G +G ++ P ++ +V V+ G+ H + L+ D ++Y G
Sbjct: 639 GC----GACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSM 694
Query: 233 GQLGR 237
GQ G+
Sbjct: 695 GQCGQ 699
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/110 (35%), Positives = 54/110 (49%), Gaps = 11/110 (10%)
Query: 63 TEPGLVLTLGQGDVGQLGLGEN-VMERKKPALVSIPEDVV--QAEAGGMHTVCLSKSGQV 119
T+ G V T GQ + +GL E +P + + V+ G HT+ L+ +G V
Sbjct: 4255 TKDGHVYTFGQDRL--IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDV 4312
Query: 120 YSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVV-QVSAGDSHTAALT 166
Y++G N EG LG V +V G LQ K V Q+SAG H+AA T
Sbjct: 4313 YAWGSNSEGQLGLGHTNHVREPTLVTG---LQGKNVRQISAGRCHSAAWT 4359
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 97.8 bits (242), Expect = 2e-20
Identities = 92/334 (27%), Positives = 161/334 (48%), Gaps = 34/334 (10%)
Query: 80 GLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGS 139
G ++R++ A S +++QA +G H++ L + +V S G N G LGR + G
Sbjct: 6 GADSRELQRRRTA-GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64
Query: 140 EMVPGKVELQEKVVQ--VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
+P ++ E ++ VS G H+ A+ GRVF WG+ + G +G+ E + S P
Sbjct: 65 --LPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPK 120
Query: 198 QVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLL 255
++ D+ +++V+ G+ H + L+ D +++ G GQLG E F ++ Q
Sbjct: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE-FPSQASPQ------ 173
Query: 256 VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE---SCF 312
+ R G Q A GA+ +FA+S G +G+G ++ QL G
Sbjct: 174 -------RVRSLEGIPLAQVAAGGAH-SFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225
Query: 313 IPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLI 372
P ++ + KN ++ S G HT + +GK ++ G G+LG E++ P L+
Sbjct: 226 KPLSVGALKNLGVVYI--SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG-PQLV 282
Query: 373 SRLPA-VSSVACGA--SVGYAVTKDGRVFAWGMG 403
R+ VS + CG+ ++ Y T G+V ++G G
Sbjct: 283 ERIDGLVSQIDCGSYHTLAYVHT-TGQVVSFGHG 315
Score = 87.4 bits (215), Expect = 2e-17
Identities = 77/238 (32%), Positives = 107/238 (44%), Gaps = 25/238 (10%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHTVCLSKSGQVYSFG 123
G V G G GQLG+GE P + D ++Q G H++ LSK QV+S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 124 CNDEGALGRDTSVEGSEMVPGKVELQEKV--VQVSAGDSHTAALTDDGRVFLWGSFRDNN 181
N G LG S+ P +V E + QV+AG +H+ AL+ G F WGS
Sbjct: 154 KNSHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212
Query: 182 GVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 239
+ +S P+ V ++ VV ++ G+ H +LT DG ++T G GQLG P
Sbjct: 213 LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272
Query: 240 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH-EGHVYGFG 296
+ G Q +ER+ G V D CG+Y T A H G V FG
Sbjct: 273 T--PEKRGPQLVERI-------------DGLVSQID--CGSYHTLAYVHTTGQVVSFG 313
Score = 80.5 bits (197), Expect = 3e-15
Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 30/252 (11%)
Query: 205 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGR----QGLERLLVPKCV 260
+++ ASG H ++L + + + G +GQLGR A RG Q LE L+V
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG---AQRGELPEPIQALETLIVDL-- 79
Query: 261 MLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG-TESCFIPQNLTS 319
CG + A+ H+G V+ +G + QLG E F P+ + +
Sbjct: 80 ---------------VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124
Query: 320 FKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV- 378
N K + S G +H++ + + + +S G+ +G+LGLG+ ++ P + L +
Sbjct: 125 L-NDIKI-IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182
Query: 379 -SSVACGASVGYAVTKDGRVFAWGMGTNYQLG-TGQDEDAWSPVEMMGKQLENRVVLSVS 436
+ VA G + +A++ G F WG + QL +G++ S + L+N V+ +S
Sbjct: 183 LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYIS 242
Query: 437 SGGQHTVLLVKD 448
G HT +L +D
Sbjct: 243 CGDAHTAVLTQD 254
Score = 72.8 bits (177), Expect = 6e-13
Identities = 77/307 (25%), Positives = 135/307 (43%), Gaps = 38/307 (12%)
Query: 151 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMV-PVQVQLDVPVVKVA 209
+++Q ++G+ H+ L + RV G ++ G +G + + P+Q + V V+
Sbjct: 24 ELLQAASGERHSLLLLTNHRVLSCGD--NSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 210 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 269
G +H + + G ++ G G +GQLG + E E PK +M +
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLG-IGEF---------KEISFTPKKIM-----TLN 126
Query: 270 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSW 327
++ CG Y + A+S + V+ +G +++ QLG G E S PQ + S + +
Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIPLAQ 185
Query: 328 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG--EGAEEKSIPTLISRLP--AVSSVAC 383
V G H+ + G ++ G G+L L + + P + L V ++C
Sbjct: 186 VAAGGA--HSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243
Query: 384 GASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV-EMMGKQLENRV---VLSVSSGG 439
G + +T+DG+VF +G + QLG +SP E G QL R+ V + G
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLG-------YSPTPEKRGPQLVERIDGLVSQIDCGS 296
Query: 440 QHTVLLV 446
HT+ V
Sbjct: 297 YHTLAYV 303
Score = 65.5 bits (158), Expect = 1e-10
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 6/185 (3%)
Query: 263 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 322
++ GS G Q A G + + V G ++ QLG G + +P+ + + +
Sbjct: 16 RTAGSPGAELLQAA-SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74
Query: 323 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--S 380
V S G+ H++ + +G+ ++ G G+LG+GE E P I L +
Sbjct: 75 LIVDLV--SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQ 132
Query: 381 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQ 440
V+CG A++KD +VF+WG ++ QLG G++ + + + + + LE + V++GG
Sbjct: 133 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV-RSLEGIPLAQVAAGGA 191
Query: 441 HTVLL 445
H+ L
Sbjct: 192 HSFAL 196
Score = 61.6 bits (148), Expect = 1e-09
Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 6/123 (4%)
Query: 331 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 388
+ G+ H++ + + + S G G+LG GA+ +P I L V V+CG
Sbjct: 29 ASGERHSLLLLTNHRVLSCGDNSRGQLGR-RGAQRGELPEPIQALETLIVDLVSCGKEHS 87
Query: 389 YAVTKDGRVFAWGMGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 447
AV GRVFAWG G+ QLG G+ E +++P ++M L + ++ VS G H++ L K
Sbjct: 88 LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM--TLNDIKIIQVSCGHYHSLALSK 145
Query: 448 DKE 450
D +
Sbjct: 146 DSQ 148
Score = 36.2 bits (82), Expect = 0.063
Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVC-LS 114
+H + T+ G V T G GQLG E++ P LV + +V Q + G HT+ +
Sbjct: 246 AHTAVLTQDGKVFTFGDNRSGQLGYSP-TPEKRGPQLVERIDGLVSQIDCGSYHTLAYVH 304
Query: 115 KSGQVYSFG 123
+GQV SFG
Sbjct: 305 TTGQVVSFG 313
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 72 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 129
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
Query: 130 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 189
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
Query: 190 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 242
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
Query: 243 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
Query: 301 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 354
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
Query: 355 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 397
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
Query: 398 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 445
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
Score = 70.1 bits (170), Expect = 4e-12
Identities = 93/370 (25%), Positives = 145/370 (39%), Gaps = 40/370 (10%)
Query: 44 CGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQ 102
C P + T H + T+ G + G GQLGLG + P + Q
Sbjct: 46 CKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQ 105
Query: 103 AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSH 161
G T+ L+++GQV S G N G LG +VP +EL +EKVV ++AG H
Sbjct: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRH 164
Query: 162 TAALTDDGRVFLWGSFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHL 215
A T G VF WG+ + G G P+ K V + + V +G+DH
Sbjct: 165 AVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHS 224
Query: 216 VMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQD 275
LT G++Y G + GQL AN + + + C + +
Sbjct: 225 ASLTDAGEVYVWGSNKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTA 269
Query: 276 AFCGAYFTFAISHEGHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFK 321
+ G A + G ++ +G ++Y QLG + F+ P ++ S
Sbjct: 270 IWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSP 329
Query: 322 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSV 381
+ S G H + + G YS G E+G G G A + P + L + S +
Sbjct: 330 HCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGL 387
Query: 382 ACGASVGYAV 391
G G+++
Sbjct: 388 LVGCGAGHSL 397
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
Query: 352 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 410
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
Query: 411 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
V +L V+ +++G +H V
Sbjct: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
Score = 34.7 bits (78), Expect = 0.18
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 99
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
Query: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 159
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
Query: 160 SHTAAL 165
H+ AL
Sbjct: 394 GHSLAL 399
Score = 32.3 bits (72), Expect = 0.90
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 386 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 445
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 89.4 bits (220), Expect = 6e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 143 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 200
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
Query: 201 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 258
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
Query: 259 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
Query: 319 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 378
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
Query: 379 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 436
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
Query: 437 SGGQHT 442
HT
Sbjct: 292 CHSAHT 297
Score = 73.2 bits (178), Expect = 5e-13
Identities = 74/267 (27%), Positives = 120/267 (44%), Gaps = 29/267 (10%)
Query: 38 RSCQGACGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-- 95
+ +G CG H STE G+V G QLG G + P V
Sbjct: 66 KKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTN 124
Query: 96 -IPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVE---LQEK 151
+ + VV+ G H++ L+ G+V+++G N+ G +G ++ ++ P KV ++
Sbjct: 125 LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKR 182
Query: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVA 209
VV ++ G + + A+ D+G V+ WG + NG +G L + PV+V V V ++
Sbjct: 183 VVGIACGQTSSMAVLDNGEVYGWG--YNGNGQLG-LGNNGNQLTPVRVAALHSVCVNQIV 239
Query: 210 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 269
G H + LT +G LY G GQLG N+ LL P +M++ +
Sbjct: 240 CGYAHTLALTDEGLLYAWGANTYGQLGT-----GNK------NNLLSPAHIMVE----KE 284
Query: 270 HVRFQDAFCGAYFTFAISHEGHVYGFG 296
V A A+ + A + GHVY +G
Sbjct: 285 RVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 23/215 (10%)
Query: 107 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAAL 165
G H + ++ G VY++G N LG T+ +G V L ++VV+V+ G H+ AL
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMAL 143
Query: 166 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-VVKVASGNDHLVMLTADG 222
DG VF WG +N G +G + P +V L + VV +A G + + +G
Sbjct: 144 AADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRVVGIACGQTSSMAVLDNG 200
Query: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF 282
++Y G GQLG N G + L P V + V CG
Sbjct: 201 EVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV-----AALHSVCVNQIVCGYAH 244
Query: 283 TFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 317
T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
Score = 53.5 bits (127), Expect = 4e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 124
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 125 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 181
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
Query: 182 GVI 184
++
Sbjct: 318 VIL 320
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 91 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 142
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
Query: 143 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 190
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
Query: 191 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 250
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
Query: 251 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 310
G V A+S +G ++G+G S Y QL + +
Sbjct: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
Query: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
Query: 371 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 419
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
Query: 420 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 447
V M G+ ++ V+ G H V L K
Sbjct: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 83.2 bits (204), Expect = 4e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 68 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 125
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
Query: 126 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
Query: 183 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 239
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
Query: 240 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 299
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
Query: 300 YHQLGTPGTESCFIPQNLTSFKN 322
Y QLGT + P +T K+
Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Score = 78.2 bits (191), Expect = 1e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 214 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 273
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
Query: 274 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 333
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
Query: 334 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 391
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Query: 392 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 442
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 303 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 360
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
Query: 361 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 419
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 420 VEMMGKQLENRVVLSVSSG 438
+ G L+N+VV++++ G
Sbjct: 196 RRVTG-CLQNKVVVTIACG 213
Score = 58.5 bits (140), Expect = 1e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 64 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 121
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
Query: 122 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 179
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
Query: 180 NNGVI 184
+ ++
Sbjct: 340 QSVIL 344
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 81.3 bits (199), Expect = 2e-15
Identities = 89/379 (23%), Positives = 156/379 (41%), Gaps = 58/379 (15%)
Query: 99 DVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK------- 151
+VVQ AG +++SG++ + GA G ++PG VE +
Sbjct: 333 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-------GGGSLLPGAVEQPQPQFISRFL 385
Query: 152 -------VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEPMKKSMVPVQVQLD 202
+ V+ GD TA LTD G + +GS +NG +G L + + + V+ L
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGS--GSNGCLGHGSLTDISQPTI-VEALLG 442
Query: 203 VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVML 262
+V+VA G H++ L+ + +L+ G G+ G+LG R +++ +P
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLG-----LGTRESHSCPQQVPMPP---- 493
Query: 263 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG------------TES 310
G Q CG + ++ G G + +++LG E
Sbjct: 494 ---GQEA----QRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEE 546
Query: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370
L S + + G H+ + + G Y+ G ++G+LG ++ P
Sbjct: 547 ALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PC 605
Query: 371 LISRLPAV--SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 428
+ L + + VACG + A+ + V++WG G +LG +DEDA P + +
Sbjct: 606 KVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETH 664
Query: 429 NRVVLSVSSGGQHTVLLVK 447
V SVS +T+L V+
Sbjct: 665 PYTVTSVSCCHGNTLLAVR 683
Score = 77.0 bits (188), Expect = 3e-14
Identities = 71/259 (27%), Positives = 110/259 (42%), Gaps = 36/259 (13%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVS--IPEDVVQAEAGGMHTVCLSKSGQVY 120
T+ G+++T G G G LG G ++ + +P +V + ++VQ G H + LS +++
Sbjct: 407 TDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELF 465
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTDDGRVFLWGSFR 178
++G D G LG T S P +V + ++ +V G + LT G+ GS R
Sbjct: 466 AWGRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNR 523
Query: 179 DNNGVIGLL----EPMKKSMVPVQVQLDV---------PVVKVASGNDHLVMLTADGDLY 225
N + L EP+ V + + P++ + G H +TA GD Y
Sbjct: 524 FNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCY 583
Query: 226 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 285
T G + GQLG RG R K +G G ++ CG FT A
Sbjct: 584 TFGSNQHGQLG----TNTRRGSR-----------APCKVQGLEG-IKMAMVACGDAFTVA 627
Query: 286 ISHEGHVYGFGLSNYHQLG 304
I E VY +G +LG
Sbjct: 628 IGAESEVYSWGKGARGRLG 646
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/324 (25%), Positives = 130/324 (40%), Gaps = 41/324 (12%)
Query: 148 LQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP------VQVQL 201
L +VVQV+AG + A +T GR+ LW + G LL + P ++ Q
Sbjct: 330 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS 389
Query: 202 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 261
V + VA G+ LT G + T G G G LG G + + + + ++
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLG--------HGSLTDISQPTIVEALL 441
Query: 262 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 321
G+ Q A CGA A+S E ++ +G + +LG ES PQ +
Sbjct: 442 -------GYEMVQVA-CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPP 493
Query: 322 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-----------EGAEEKSIPT 370
V G ++ + G+A + G + +LGL + EE T
Sbjct: 494 GQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
Query: 371 LISRLP----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 426
L+ P + S+ G + AVT G + +G + QLGT + +P ++ G
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-- 609
Query: 427 LENRVVLSVSSGGQHTVLLVKDKE 450
LE + V+ G TV + + E
Sbjct: 610 LEGIKMAMVACGDAFTVAIGAESE 633
Score = 33.9 bits (76), Expect = 0.31
Identities = 34/113 (30%), Positives = 44/113 (38%), Gaps = 11/113 (9%)
Query: 45 GPSPPDQKTR-----PVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED 99
G +P DQ+ +H + T G T G GQLG R P V E
Sbjct: 554 GSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-PCKVQGLEG 612
Query: 100 VVQA--EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 150
+ A G TV + +VYS+G G LGR G +P V+L E
Sbjct: 613 IKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAG---LPRPVQLDE 662
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 80.1 bits (196), Expect = 4e-15
Identities = 78/313 (24%), Positives = 128/313 (40%), Gaps = 41/313 (13%)
Query: 151 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVAS 210
K+ V G H L+ DG+ F + ++ K + + + ++++
Sbjct: 98 KIHSVDQGAEHMLILSSDGKPFEYDNYS------------MKHLRFESILQEKKIIQITC 145
Query: 211 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH 270
G+ H + L+ G+L+ G GQLG V F + Q +E L
Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL--------------AG 190
Query: 271 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF 330
V G + A+S G++Y +G + QLG TES P + N +V
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC 250
Query: 331 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVG 388
G H+ + +G ++ G ++G+LG E P L++ L V+ +ACG
Sbjct: 251 GGS--HSALLTQDGLLFTFGAGKHGQLGHNSTQNELR-PCLVAELVGYRVTQIACGRWHT 307
Query: 389 YAVTKD-GRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSS--------GG 439
A D G+VF++G G + QLG G D P+ + E + S +S GG
Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367
Query: 440 QHTVLLVKDKEQS 452
++LL KE S
Sbjct: 368 NQSILLWIKKENS 380
Score = 72.4 bits (176), Expect = 8e-13
Identities = 70/313 (22%), Positives = 137/313 (43%), Gaps = 41/313 (13%)
Query: 65 PGLVLTLGQGDVG----QLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 120
PG + L +G G QL G K + + + G H + LS G+ +
Sbjct: 60 PGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPF 119
Query: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 180
+ L ++ ++ ++K++Q++ GD H+ AL+ G +F WG ++
Sbjct: 120 EYDNYSMKHLRFESILQ-----------EKKIIQITCGDYHSLALSKGGELFAWG--QNL 166
Query: 181 NGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG-R 237
+G +G+ + P V+ VP+ ++++G H + L+ G++Y+ G E GQLG
Sbjct: 167 HGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLG 226
Query: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
E + +GL+ + + + CG + ++ +G ++ FG
Sbjct: 227 HTESKDDPSLIEGLD-----------------NQKVEFVACGGSHSALLTQDGLLFTFGA 269
Query: 298 SNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE-GKAYSLGRAEYGR 356
+ QLG T++ P + + + + G+ HT+ S+ GK +S G + G+
Sbjct: 270 GKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
Query: 357 LGLGEGAEEKSIP 369
LG G G ++ +P
Sbjct: 328 LGNG-GTRDQLMP 339
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/187 (30%), Positives = 91/187 (48%), Gaps = 14/187 (7%)
Query: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALV----SIPEDVVQAEAGGMHTVCL 113
H ++ G + GQ GQLG+G P +V +P + Q AG H++ L
Sbjct: 149 HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVP--LAQISAGEAHSMAL 206
Query: 114 SKSGQVYSFGCNDEG--ALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRV 171
S SG +YS+G N+ G LG S + ++ G +KV V+ G SH+A LT DG +
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLD--NQKVEFVACGGSHSALLTQDGLL 264
Query: 172 FLWGSFRDNNGVIGLLEPMKKSMVPVQVQL-DVPVVKVASGNDHLVMLTAD-GDLYTLGC 229
F +G+ +G +G + + +L V ++A G H + +D G +++ G
Sbjct: 265 FTFGA--GKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGS 322
Query: 230 GEQGQLG 236
G+ GQLG
Sbjct: 323 GKDGQLG 329
Score = 55.1 bits (131), Expect = 1e-07
Identities = 47/180 (26%), Positives = 84/180 (46%), Gaps = 26/180 (14%)
Query: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEA-GGMHTVCLSK 115
+H + G + + G+ + GQLGLG + + + V+ A GG H+ L++
Sbjct: 201 AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQ 260
Query: 116 SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVE--LQEKVVQVSAGDSHTAALTDD-GRVF 172
G +++FG G LG +++ +E+ P V + +V Q++ G HT A D G+VF
Sbjct: 261 DGLLFTFGAGKHGQLGHNST--QNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVF 318
Query: 173 LWGSFRD----NNGVIGLLEPMKKSMVPVQVQ-----------LDVPVVKVASGNDHLVM 217
+GS +D N G L P+ PV+V + ++ +A GN +++
Sbjct: 319 SFGSGKDGQLGNGGTRDQLMPL-----PVKVSSSEELKLESHTSEKELIMIAGGNQSILL 373
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 69.7 bits (169), Expect = 5e-12
Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)
Query: 202 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 261
D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80
Query: 262 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 321
G V A+S +G ++G+G S Y QL + + F
Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
Query: 322 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 376
K GG V ++ EG + G YG LG G E ++P +I
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192
Query: 377 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 429
VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251
Query: 430 RVVLSVSSGGQHTVLLVK 447
V+ G H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264
Score = 55.5 bits (132), Expect = 1e-07
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)
Query: 123 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 177
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 178 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 237
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
Query: 298 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 349
Y LG P +P+ LT F N G + ++G+ +
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221
Query: 350 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 384
G+ G LG+G E++ P ++ VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 158
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
Query: 159 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 208
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
Query: 209 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
Query: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 69.7 bits (169), Expect = 5e-12
Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 37/258 (14%)
Query: 202 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 261
D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG----------- 80
Query: 262 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFK 321
G V A+S +G ++G+G S Y QL + + F
Sbjct: 81 ----GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
Query: 322 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP----- 376
K GG V ++ EG + G YG LG G E ++P +I
Sbjct: 137 GVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTE 192
Query: 377 -----AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGKQLEN 429
VS + CG S A+T G +F WG LG G+ ED + P V M G+ ++
Sbjct: 193 FNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD- 251
Query: 430 RVVLSVSSGGQHTVLLVK 447
V+ G H V L K
Sbjct: 252 -----VACGVDHMVTLAK 264
Score = 55.5 bits (132), Expect = 1e-07
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 34/275 (12%)
Query: 123 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 177
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 178 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 237
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
Query: 298 SNYHQLGT-PGTESCFIPQ-------NLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 349
Y LG P +P+ LT F N G + ++G+ +
Sbjct: 165 --YGILGKGPNLVESAVPEMIPPTLFGLTEF-NPEIQVSRIRCGLSRFAALTNKGELFVW 221
Query: 350 GRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACG 384
G+ G LG+G E++ P ++ VACG
Sbjct: 222 GKNIRGCLGIGR-LEDQYFPWRVTMPGEPVDVACG 255
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 158
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
Query: 159 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 208
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
Query: 209 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
Query: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 69.7 bits (169), Expect = 5e-12
Identities = 67/223 (30%), Positives = 96/223 (43%), Gaps = 43/223 (19%)
Query: 27 RAAASRRVPGARSCQGACGPSPPDQKTRPVS----HRSHSTEPGLVLTLGQGDVGQLGLG 82
RA S R P R P P+ + R + H G V + G G GQLG G
Sbjct: 141 RAYVSPRAPFYR-------PLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHG 193
Query: 83 ENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFGCNDEGALG---RDTSVE 137
E + P L+ + +V AE AGG H+VC+S++G +Y +G N+ G L R+ + +
Sbjct: 194 TLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
Query: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
G + EL E QV R G P ++ P
Sbjct: 253 GETVAREATELNEDGSQVK---------------------RTGGAEDGAPAPF-IAVQPF 290
Query: 198 QVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236
LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 291 PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 123 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 177
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
Query: 178 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 231
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
Query: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291
G+L +P A R R L P+ +R + GA + G
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
Query: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
Query: 352 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 374
E G+L L GE GAE+ + P L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
Query: 375 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 428
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
Query: 429 NRVVLSVSSGGQHTVLLVKDKEQS 452
V +V+ G +T + +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 69.7 bits (169), Expect = 5e-12
Identities = 67/223 (30%), Positives = 96/223 (43%), Gaps = 43/223 (19%)
Query: 27 RAAASRRVPGARSCQGACGPSPPDQKTRPVS----HRSHSTEPGLVLTLGQGDVGQLGLG 82
RA S R P R P P+ + R + H G V + G G GQLG G
Sbjct: 141 RAYVSPRAPFYR-------PLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHG 193
Query: 83 ENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFGCNDEGALG---RDTSVE 137
E + P L+ + +V AE AGG H+VC+S++G +Y +G N+ G L R+ + +
Sbjct: 194 TLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
Query: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
G + EL E QV R G P ++ P
Sbjct: 253 GETVAREATELNEDGSQVK---------------------RTGGAEDGAPAPF-IAVQPF 290
Query: 198 QVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236
LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 291 PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 123 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 177
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
Query: 178 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 231
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
Query: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291
G+L +P A R R L P+ +R + GA + G
Sbjct: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
Query: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
Query: 352 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 374
E G+L L GE GAE+ + P L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
Query: 375 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 428
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
Query: 429 NRVVLSVSSGGQHTVLLVKDKEQS 452
V +V+ G +T + +K +S
Sbjct: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 60.5 bits (145), Expect = 3e-09
Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 5/155 (3%)
Query: 290 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 349
G V+ +G ++ +LG G+E C IPQN+ + G + + G ++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 782
Query: 350 GRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQL 408
G+ +Y RLG + + + R + VA GA AV G+V+AWG + Q
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 409 GTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
G G P+ + G LE + ++ V+ G H+V
Sbjct: 843 GNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 875
Score = 58.9 bits (141), Expect = 9e-09
Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 124
GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784
Query: 125 NDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVI 184
D LG + V ++ + +K+V V+ G H A+ D G+V+ WG
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844
Query: 185 GLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 219
G +K M+ VQ ++ VA G+ H V T
Sbjct: 845 GTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 878
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 121
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 774 TKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 833
Query: 122 FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 166
+G ND G G T+V M+ +E Q K++ V+ G SH+ A T
Sbjct: 834 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 878
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/110 (35%), Positives = 55/110 (50%), Gaps = 6/110 (5%)
Query: 344 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 401
G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 402 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 451
G ++LG D + G L + ++ V+ G QH L V D Q
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 830
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 24/186 (12%)
Query: 212 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268
+D+ +LT G +++ G G+ G+LGR GG +G +P+ + + +
Sbjct: 712 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 758
Query: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 328
G + + CGA F A++ G V+ +G +Y +LG Q + + V
Sbjct: 759 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHV 815
Query: 329 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 386
G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S
Sbjct: 816 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 872
Query: 387 VGYAVT 392
A T
Sbjct: 873 HSVAWT 878
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 60.1 bits (144), Expect = 4e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 288 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 347
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
Query: 348 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 405
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
Query: 406 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
Q G G P + G LE + ++ V+ G H+V
Sbjct: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Score = 57.4 bits (137), Expect = 3e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 343 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 400
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
Query: 401 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 451
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 67 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 125
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 126 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 183
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
Query: 184 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 219
G +K + VQ ++ VA G+ H V T
Sbjct: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
Score = 54.3 bits (129), Expect = 2e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 121
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
Query: 122 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 166
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 50.4 bits (119), Expect = 3e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 205 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 264
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
Query: 265 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 324
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
Query: 325 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 382
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
Query: 383 CGASVGYAVT 392
CG+S A T
Sbjct: 167 CGSSHSVAWT 176
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 60.1 bits (144), Expect = 4e-09
Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 7/156 (4%)
Query: 290 GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 349
G V+ +G ++ +LG G+E C IPQN+ + G + + G ++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 732
Query: 350 GRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQ 407
G+ +Y RLG + P ++ L + VA GA AV G+V+AWG + Q
Sbjct: 733 GKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791
Query: 408 LGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
G G P+ + G LE + ++ V+ G H+V
Sbjct: 792 QGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSV 825
Score = 58.9 bits (141), Expect = 9e-09
Identities = 49/157 (31%), Positives = 73/157 (46%), Gaps = 6/157 (3%)
Query: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGC 124
GLV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 125 NDEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 182
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 183 VIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 219
G +K M+ VQ ++ VA G+ H V T
Sbjct: 793 GNGTTTVNRKPML-VQGLEGQKIMCVACGSSHSVAWT 828
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/110 (36%), Positives = 56/110 (50%), Gaps = 6/110 (5%)
Query: 344 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWG 401
G +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 402 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 451
G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 780
Score = 55.1 bits (131), Expect = 1e-07
Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 121
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 724 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 783
Query: 122 FGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 166
+G ND G G T+V M+ +E Q K++ V+ G SH+ A T
Sbjct: 784 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 828
Score = 48.9 bits (115), Expect = 9e-06
Identities = 51/186 (27%), Positives = 84/186 (45%), Gaps = 24/186 (12%)
Query: 212 NDHLVMLTA---DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268
+D+ +LT G +++ G G+ G+LGR GG +G +P+ + + +
Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGR--------GGSEGCN---IPQNI--ERLNGQ 708
Query: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWV 328
G + + CGA F A++ G V+ +G +Y +LG PQ + + V
Sbjct: 709 GVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHV 765
Query: 329 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 386
G QH MDS G+ Y+ G ++G+ G G + P L+ L + VACG+S
Sbjct: 766 AV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PMLVQGLEGQKIMCVACGSS 822
Query: 387 VGYAVT 392
A T
Sbjct: 823 HSVAWT 828
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,867,423
Number of Sequences: 37866
Number of extensions: 907755
Number of successful extensions: 3573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 2583
Number of HSP's gapped (non-prelim): 335
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.