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Search of human proteins with 22027525
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6
[Homo sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 1546 0.0
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 828 0.0
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 816 0.0
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 804 0.0
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 804 0.0
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 786 0.0
gi|71274148 pleckstrin homology domain containing, family G (wit... 114 5e-25
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 112 1e-24
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 108 2e-23
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 108 2e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 100 4e-21
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 100 7e-21
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 99 1e-20
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 99 1e-20
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 90 9e-18
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 89 1e-17
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 87 6e-17
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 87 6e-17
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 86 1e-16
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 86 1e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 86 2e-16
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 85 3e-16
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 85 3e-16
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 77 5e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 77 8e-14
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 74 4e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 72 3e-12
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 70 6e-12
gi|55749621 pleckstrin homology domain containing, family G, mem... 70 7e-12
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 70 1e-11
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 1546 bits (4003), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
Sbjct: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
Query: 61 QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG 120
QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
Sbjct: 61 QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG 120
Query: 121 RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS 180
RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
Sbjct: 121 RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS 180
Query: 181 VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN 240
VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
Sbjct: 181 VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN 240
Query: 241 YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC 300
YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
Sbjct: 241 YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC 300
Query: 301 QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG 360
QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
Sbjct: 301 QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG 360
Query: 361 ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD 420
ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
Sbjct: 361 ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD 420
Query: 421 LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM 480
LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
Sbjct: 421 LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM 480
Query: 481 LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL 540
LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
Sbjct: 481 LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL 540
Query: 541 EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL 600
EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
Sbjct: 541 EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL 600
Query: 601 RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL 660
RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
Sbjct: 601 RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL 660
Query: 661 KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA 720
KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
Sbjct: 661 KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA 720
Query: 721 LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP 776
LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
Sbjct: 721 LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP 776
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 828 bits (2138), Expect = 0.0
Identities = 422/714 (59%), Positives = 534/714 (74%), Gaps = 47/714 (6%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK +P
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 QTEADCINNINDFLKGC-ATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATED--QLSER 117
++E++C++NI +FL+GC A+L++E FD +DLY G NF+KVLS+L+ +NK T D S+
Sbjct: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
Query: 118 PCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNED 177
C R SS + Q + T Q Q ++++MT+N ++QL+V+A+FNF+QTNED
Sbjct: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
Query: 178 ELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKA------VKG 231
ELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE+K+SE+P+SPK+ KG
Sbjct: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
Query: 232 FETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEE 291
F+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRPLQ++ LS+ ++ L+GN EE
Sbjct: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
Query: 292 VCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++YL YCANHPSAVNVLT+HS+E
Sbjct: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
Query: 352 LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAF 411
L +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+ELERHMED H D QDI K++ AF
Sbjct: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
Query: 412 KTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYL 471
K L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV +MSQV++Q EEK ERYL
Sbjct: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
Query: 472 MLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCN 531
+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E + FEI+G+ +ERI+V CN
Sbjct: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
Query: 532 NNQDFQEWLEQLNRLIR------------------------GPASCSSLSKTSSSSCSAH 567
N QD QEW+E L + + P+S + SK + + + H
Sbjct: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
Query: 568 S--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESS 620
+ S G P GPLEPP+ KPWSLSCLRPAPPLRPSAAL YKE + S
Sbjct: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKE-------DLS 653
Query: 621 KSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQ 674
KSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQILKVIEAYCTSA +Q
Sbjct: 654 KSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQ 707
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 816 bits (2109), Expect = 0.0
Identities = 422/735 (57%), Positives = 535/735 (72%), Gaps = 68/735 (9%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK +P
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 QTEADCINNINDFLKGC-ATLQVEI---------------------FDPDDLYSGVNFSK 98
++E++C++NI +FL+GC A+L++E+ FD +DLY G NF+K
Sbjct: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
Query: 99 VLSTLLAVNKATED--QLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMT 156
VLS+L+ +NK T D S+ C R SS + Q + T Q Q ++++MT
Sbjct: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
Query: 157 ENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVRE 216
+N ++QL+V+A+FNF+QTNEDELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
Query: 217 IKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRP 270
+K+SE+P+SPK+ KGF+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRP
Sbjct: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
Query: 271 LQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSM 330
LQ++ LS+ ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++
Sbjct: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
Query: 331 YLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQEL 390
YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+EL
Sbjct: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
Query: 391 ERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNV 450
ERHMED H D QDI K++ AFK L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV
Sbjct: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
Query: 451 IFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIE 510
+MSQV++Q EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E
Sbjct: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
Query: 511 GNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR---------------------- 548
+ FEI+G+ +ERI+V CNN QD QEW+E L + +
Sbjct: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
Query: 549 --GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPP 599
P+S + SK + + + H+ S G P GPLEPP+ KPWSLSCLRPAPP
Sbjct: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
Query: 600 LRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQI 659
LRPSAAL YKE + SKSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQI
Sbjct: 661 LRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQI 713
Query: 660 LKVIEAYCTSANFQQ 674
LKVIEAYCTSA +Q
Sbjct: 714 LKVIEAYCTSAKTRQ 728
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 804 bits (2077), Expect = 0.0
Identities = 405/645 (62%), Positives = 503/645 (77%), Gaps = 44/645 (6%)
Query: 155 MTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYV 214
MT+N ++QL+V+A+FNF+QTNEDELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 215 REIKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYL 268
RE+K+SE+P+SPK+ KGF+T + K+YY VVLQNIL+TE EY+KELQ++L TYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 269 RPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFK 328
RPLQ++ LS+ ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 329 SMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQ 388
++YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 389 ELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG 448
ELERHMED H D QDI K++ AFK L QCQ++RKRK+LELQIL+E I+ WEG+DIK LG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 449 NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDE 508
NV +MSQV++Q EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 509 IEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR-------------------- 548
E + FEI+G+ +ERI+V CNN QD QEW+E L + +
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 549 ----GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPA 597
P+S + SK + + + H+ S G P GPLEPP+ KPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 598 PPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDA 657
PPLRPSAAL YKE + SKSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDA
Sbjct: 481 PPLRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDA 533
Query: 658 QILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDT 717
QILKVIEAYCTSA +Q SS+RK+S PQVLLPEEEK+I+EET+SNGQT++EEKSLVDT
Sbjct: 534 QILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDT 593
Query: 718 VYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDE 762
VYALKDEV+EL+Q+NK+MK+ LEEE ++R+DLEKLVR++LK ++
Sbjct: 594 VYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 638
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 804 bits (2077), Expect = 0.0
Identities = 405/645 (62%), Positives = 503/645 (77%), Gaps = 44/645 (6%)
Query: 155 MTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYV 214
MT+N ++QL+V+A+FNF+QTNEDELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 215 REIKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYL 268
RE+K+SE+P+SPK+ KGF+T + K+YY VVLQNIL+TE EY+KELQ++L TYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 269 RPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFK 328
RPLQ++ LS+ ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 329 SMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQ 388
++YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 389 ELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG 448
ELERHMED H D QDI K++ AFK L QCQ++RKRK+LELQIL+E I+ WEG+DIK LG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 449 NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDE 508
NV +MSQV++Q EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 509 IEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR-------------------- 548
E + FEI+G+ +ERI+V CNN QD QEW+E L + +
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 549 ----GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPA 597
P+S + SK + + + H+ S G P GPLEPP+ KPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 598 PPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDA 657
PPLRPSAAL YKE + SKSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDA
Sbjct: 481 PPLRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDA 533
Query: 658 QILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDT 717
QILKVIEAYCTSA +Q SS+RK+S PQVLLPEEEK+I+EET+SNGQT++EEKSLVDT
Sbjct: 534 QILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDT 593
Query: 718 VYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDE 762
VYALKDEV+EL+Q+NK+MK+ LEEE ++R+DLEKLVR++LK ++
Sbjct: 594 VYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 638
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 786 bits (2031), Expect = 0.0
Identities = 410/713 (57%), Positives = 510/713 (71%), Gaps = 74/713 (10%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
Query: 61 QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATED--QLSERP 118
FD +DLY G NF+KVLS+L+ +NK T D S+
Sbjct: 56 -----------------------TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSV 92
Query: 119 CGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDE 178
C R SS + Q + T Q Q ++++MT+N ++QL+V+A+FNF+QTNEDE
Sbjct: 93 CARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDE 152
Query: 179 LSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKA------VKGF 232
LS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE+K+SE+P+SPK+ KGF
Sbjct: 153 LSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGF 212
Query: 233 ETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEV 292
+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRPLQ++ LS+ ++ L+GN EE+
Sbjct: 213 DTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEI 272
Query: 293 CTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDEL 352
C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++YL YCANHPSAVNVLT+HS+EL
Sbjct: 273 CSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEEL 332
Query: 353 EQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
+FME +GASSPGIL+LTT LSKPFMRL+KY TLL+ELERHMED H D QDI K++ AFK
Sbjct: 333 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
Query: 413 TLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLM 472
L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV +MSQV++Q EEK ERYL+
Sbjct: 393 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 452
Query: 473 LFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNN 532
LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E + FEI+G+ +ERI+V CNN
Sbjct: 453 LFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNN 512
Query: 533 NQDFQEWLEQLNRLIR------------------------GPASCSSLSKTSSSSCSAHS 568
QD QEW+E L + + P+S + SK + + + H+
Sbjct: 513 QQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHT 572
Query: 569 --SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSK 621
S G P GPLEPP+ KPWSLSCLRPAPPLRPSAAL YKE + SK
Sbjct: 573 LPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKE-------DLSK 625
Query: 622 SPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQ 674
SPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQILKVIEAYCTSA +Q
Sbjct: 626 SPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQ 678
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 114 bits (284), Expect = 5e-25
Identities = 88/329 (26%), Positives = 151/329 (45%), Gaps = 17/329 (5%)
Query: 225 SPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNL--STVEV 282
+PK + T+P Y V+Q IL+TE+ Y ++L+S++ YL ++ L T E
Sbjct: 98 APKTIADSATSPKLL-YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEER 156
Query: 283 TSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAV 342
++L GN +++ F L Q LE C P + C +S F +Y YC N+P +V
Sbjct: 157 SALFGNIQDIYHFNSELLQDLENCENDPV---AIAECFVSKSEEFH-IYTQYCTNYPRSV 212
Query: 343 NVLTQ--HSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPD 400
VLT+ + L +F + + L L + L KP R+ KY LL E+E H++
Sbjct: 213 AVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEG 272
Query: 401 HQDILKAIVAFKTLMGQCQDLRKRKQ--LELQILSEPIQAWEGEDIKNLGNVIFMSQVMV 458
+ +L AI + + D++++ + + LQ + + W+G D+ + G ++ +
Sbjct: 273 YDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI 332
Query: 459 QYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEI 518
Q K ER L LF +L++ R F Y+ I ++ + E +
Sbjct: 333 Q----RAKNERTLFLFDKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFH 386
Query: 519 TGNTVERIVVHCNNNQDFQEWLEQLNRLI 547
N + V + QD + W+ L RLI
Sbjct: 387 YKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 112 bits (281), Expect = 1e-24
Identities = 104/447 (23%), Positives = 192/447 (42%), Gaps = 42/447 (9%)
Query: 175 NEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVR----EIKSSERPLSPKAVK 230
++ EL GD+I V WW G + WFP+++VR + + SE S + +
Sbjct: 162 DDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEE 221
Query: 231 GFETAPLTKNYY--------TVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTV-E 281
E A +++ + T V++ I+DTE+ Y K L+ + Y+R + + + TV +
Sbjct: 222 QDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQ 281
Query: 282 VTSLLGNFEEVCTFQQTLCQALE-ECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPS 340
+ ++ GN E++ FQ+ + LE + +K + ++G C L F ++Y YC NHP
Sbjct: 282 LATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGF-AIYSEYCNNHPG 340
Query: 341 A----VNVLTQHSDELEQFMENQGASSPGI-LILTTNLSKPFMRLEKYVTLLQELERHME 395
A N++ Q + F E I + + L P ++ KY L EL ++
Sbjct: 341 ACLELANLMKQ--GKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTT 398
Query: 396 DTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGNVIF 452
H D+ +I A A K + + RKRK + ++ I WEG DI + + +
Sbjct: 399 QEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSIVGWEGLDILDRSSELI 457
Query: 453 MSQVMVQYGACEEKEERYLMLFSNVLIMLSAS-PRMSGFIYQGKIPIAGTVVTRLDEIEG 511
S + + + ++R LF + L+ R Y+G++ + + L +
Sbjct: 458 HSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRD 517
Query: 512 NDC------TFEITGNTVERIVVHCNNNQ-DFQEWL----EQLNRLIRGPASCSSLSKTS 560
DC F++ T + + + C Q D WL ++ R+ +S+
Sbjct: 518 KDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQ 577
Query: 561 SSSCSAHSSFSSTGQPRG----PLEPP 583
++ + G+ +G P+ PP
Sbjct: 578 KKLAMLNAQKAGHGKSKGYNRCPVAPP 604
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 108 bits (269), Expect = 2e-23
Identities = 102/418 (24%), Positives = 185/418 (44%), Gaps = 29/418 (6%)
Query: 154 EMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNY 213
E+ +GS + +A ++ ++ EL GD+I V WW G + GWFP+++
Sbjct: 189 ELISDGS-VVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASF 247
Query: 214 VREIKSSERPLSPKAV---------KGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLL 264
VR + + P A G E T V+ IL TE++Y K L+ +
Sbjct: 248 VRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDIC 307
Query: 265 VTYLRPLQSNNNL-STVEVTSLLGNFEEVCTFQQTLCQALEE-CSKFPENQHKVGGCLLS 322
Y+R + ++ S ++ ++ GN E++ Q+ +ALE+ ++ + ++G C L
Sbjct: 308 EGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLE 367
Query: 323 LMPHFKSMYLAYCANHPSA---VNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMR 379
F+ +Y YC NHP+A ++ LT+ S + F + + L L P +
Sbjct: 368 HQADFQ-IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQK 426
Query: 380 LEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PI 436
+ KY L EL ++ H D +D+ A+ A K + Q + RKR+ + +++ I
Sbjct: 427 ICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKN-VAQLINERKRRLENIDKIAQWQSSI 485
Query: 437 QAWEGEDIKNLGNVIFMSQVMVQYGACEEK-EERYLMLFSNVLIMLSAS-PRMSGFIYQG 494
+ WEGED+ + + S + + + K ++R LF + LI R Y+G
Sbjct: 486 EDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKG 545
Query: 495 KIPIAGTVVTRLDEIEGNDCTFEI-------TGNTVERIVVHCNNNQDFQEWLEQLNR 545
++ + G V L++ + D I G T + ++ + Q WL+ R
Sbjct: 546 RLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAR 603
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 108 bits (269), Expect = 2e-23
Identities = 102/418 (24%), Positives = 185/418 (44%), Gaps = 29/418 (6%)
Query: 154 EMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNY 213
E+ +GS + +A ++ ++ EL GD+I V WW G + GWFP+++
Sbjct: 189 ELISDGS-VVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASF 247
Query: 214 VREIKSSERPLSPKAV---------KGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLL 264
VR + + P A G E T V+ IL TE++Y K L+ +
Sbjct: 248 VRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDIC 307
Query: 265 VTYLRPLQSNNNL-STVEVTSLLGNFEEVCTFQQTLCQALEE-CSKFPENQHKVGGCLLS 322
Y+R + ++ S ++ ++ GN E++ Q+ +ALE+ ++ + ++G C L
Sbjct: 308 EGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLE 367
Query: 323 LMPHFKSMYLAYCANHPSA---VNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMR 379
F+ +Y YC NHP+A ++ LT+ S + F + + L L P +
Sbjct: 368 HQADFQ-IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQK 426
Query: 380 LEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PI 436
+ KY L EL ++ H D +D+ A+ A K + Q + RKR+ + +++ I
Sbjct: 427 ICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKN-VAQLINERKRRLENIDKIAQWQSSI 485
Query: 437 QAWEGEDIKNLGNVIFMSQVMVQYGACEEK-EERYLMLFSNVLIMLSAS-PRMSGFIYQG 494
+ WEGED+ + + S + + + K ++R LF + LI R Y+G
Sbjct: 486 EDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKG 545
Query: 495 KIPIAGTVVTRLDEIEGNDCTFEI-------TGNTVERIVVHCNNNQDFQEWLEQLNR 545
++ + G V L++ + D I G T + ++ + Q WL+ R
Sbjct: 546 RLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAR 603
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 100 bits (250), Expect = 4e-21
Identities = 68/268 (25%), Positives = 130/268 (48%), Gaps = 13/268 (4%)
Query: 169 FNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVR---EIKSSERPLS 225
+++ N+DEL+ KG II V E+ WW+G +NG+ G FPSNYV+ ++ S++ S
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCS 1223
Query: 226 PKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSL 285
+ T T+ + ++ TE+ Y +LQ + + +PL + L+ EV +
Sbjct: 1224 DLHLLDMLTP--TERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMI 1281
Query: 286 LGNFEEVCTFQQTLCQALEECSKFPENQ---HKVGGCLLSLMPHFKSMYLAYCANHPSAV 342
N++E+ L +AL K + +G L + +PH + Y+ +C+ +
Sbjct: 1282 FVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQLNGA 1340
Query: 343 NVLTQHSDELEQFME--NQGASSPGI--LILTTNLSKPFMRLEKYVTLLQELERHMEDTH 398
++ Q +DE F E + A P + L++ + KP R+ +Y +++ + + + H
Sbjct: 1341 ALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENH 1400
Query: 399 PDHQDILKAIVAFKTLMGQCQDLRKRKQ 426
PDH + A+ + L Q + + K+
Sbjct: 1401 PDHSHLKHALEKAEELCSQVNEGVREKE 1428
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 138 AVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYV-------T 190
AV + S ++ T+ EN + +A + F+ + DE+++ GDI+ V +
Sbjct: 719 AVQAPWSTAEKGPLTISAQENVK-VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDES 777
Query: 191 RVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTK 239
+ E GW G L G+TGWFP+NY +I +E P K V +AP K
Sbjct: 778 QTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPK 826
Score = 51.2 bits (121), Expect = 4e-06
Identities = 23/55 (41%), Positives = 38/55 (69%), Gaps = 2/55 (3%)
Query: 167 ARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSE 221
A + ++ + + +L+ +GD+I VT+ ++G WW GT+ + G FPSNYVR +K SE
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVR-LKDSE 1061
Score = 50.4 bits (119), Expect = 6e-06
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 5/73 (6%)
Query: 159 GSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGR-----TGWFPSNY 213
G I + ++ T ++L++ G +I + + GGWWEG L R GWFP+NY
Sbjct: 1073 GKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 214 VREIKSSERPLSP 226
V+ + ++P
Sbjct: 1133 VKLLSPGTSKITP 1145
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/136 (25%), Positives = 57/136 (41%), Gaps = 20/136 (14%)
Query: 131 SQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVT 190
S P A S+ S + Q + VE L +A + ++ ++ L+ K D+I V
Sbjct: 891 SAFTPATATGSSPSPVLGQGEKVE-------GLQAQALYPWRAKKDNHLNFNKNDVITVL 943
Query: 191 RVEEGGWWEGTLNGRTGWFPSNYVREIK------------SSERPLSPKAVKGFETAPLT 238
++ WW G + G+ GWFP +YV+ I SSE P S K V P+
Sbjct: 944 E-QQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVV 1002
Query: 239 KNYYTVVLQNILDTEK 254
+ + +E+
Sbjct: 1003 SGEEFIAMYTYESSEQ 1018
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 100 bits (248), Expect = 7e-21
Identities = 85/342 (24%), Positives = 148/342 (43%), Gaps = 46/342 (13%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSN------NNLSTVEVTSLLGNFEEVCTFQQT 298
VL IL TE++Y L+ L +L ++ N L+ V L N E++ +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 299 LCQALEEC-SKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSD--ELEQF 355
ALE C P++QH++G L F +Y YC+NH A+ +L + + + F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
Query: 356 MEN---QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
+ + G + L L P R+ KY LL+EL + HPDH + A+ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
Query: 413 TLMGQCQDL-RKRKQLE-LQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERY 470
T+ + R+ ++LE L+ L I+ WEG ++ ++ + + +++ A +ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA-GNIQERA 290
Query: 471 LMLFSNVLIMLSASPRMSG---------------FIYQGKIPIAGTVVTRLDEIEGNDCT 515
LF N+L+ R++G +I++G+I T V ++ +E
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRI---NTEVMEVENVEDGTAD 347
Query: 516 FEITGNTVER------------IVVHCNNNQDFQEWLEQLNR 545
+ G TV V ++ Q+WL+ + R
Sbjct: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIR 389
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/270 (25%), Positives = 131/270 (48%), Gaps = 9/270 (3%)
Query: 165 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPL 224
V A +++ NEDELS KG +I V ++ WW+G +NG TG FPSNYV+ S+
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Query: 225 SPKA-VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVT 283
A ++ +T + + ++ TE+ Y +LQ ++ + + + + L+ E+
Sbjct: 1165 QWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMA 1224
Query: 284 SLLGNFEEVCTFQQTLCQALEECSKFPENQ---HKVGGCLLSLMPHFKSMYLAYCANHPS 340
+ N++E+ L +AL K + +G L + + H ++ Y+ +C+ +
Sbjct: 1225 LIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFCSCQLN 1283
Query: 341 AVNVLTQHSDELEQFME--NQGASSPGI--LILTTNLSKPFMRLEKYVTLLQELERHMED 396
+L Q +DE F E + AS P + L++ L KP R+ +Y L++ + + +
Sbjct: 1284 GAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPE 1343
Query: 397 THPDHQDILKAIVAFKTLMGQCQDLRKRKQ 426
+H DH + A+ + L Q + + K+
Sbjct: 1344 SHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 55.8 bits (133), Expect = 1e-07
Identities = 32/75 (42%), Positives = 42/75 (56%), Gaps = 4/75 (5%)
Query: 157 ENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTR--VEEGGWWEGTLNGRTGWFPSNYV 214
E S + +A + F+ N DE+S GDII V V E GW G+ G GWFP NYV
Sbjct: 727 ETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 786
Query: 215 REIKSS--ERPLSPK 227
++ SS E+ +SPK
Sbjct: 787 EKMPSSENEKAVSPK 801
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 8/80 (10%)
Query: 142 TVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGT 201
+VS + Q + VE L +A ++ ++ L+ K DII V +E WW G
Sbjct: 860 SVSPIHGQGQVVE-------NLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGE 911
Query: 202 LNGRTGWFPSNYVREIKSSE 221
++G GWFP +YV+ I SE
Sbjct: 912 VHGGRGWFPKSYVKIIPGSE 931
Score = 42.0 bits (97), Expect = 0.002
Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 167 ARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVR 215
A + + +L+ +G+ I VT+ ++G WW G++ R+G FPSNYV+
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVK 1008
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/58 (29%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 174 TNEDELSVCKGDIIYVTRVEEGGWWEGTLNGR-----TGWFPSNYVREIKSSERPLSP 226
+ ++LS+ G +I + + GWW+G L R GWFP+++V+ + S +P
Sbjct: 1040 SGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATP 1097
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/270 (25%), Positives = 131/270 (48%), Gaps = 9/270 (3%)
Query: 165 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPL 224
V A +++ NEDELS KG +I V ++ WW+G +NG TG FPSNYV+ S+
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Query: 225 SPKA-VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVT 283
A ++ +T + + ++ TE+ Y +LQ ++ + + + + L+ E+
Sbjct: 1192 QWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMA 1251
Query: 284 SLLGNFEEVCTFQQTLCQALEECSKFPENQ---HKVGGCLLSLMPHFKSMYLAYCANHPS 340
+ N++E+ L +AL K + +G L + + H ++ Y+ +C+ +
Sbjct: 1252 LIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFCSCQLN 1310
Query: 341 AVNVLTQHSDELEQFME--NQGASSPGI--LILTTNLSKPFMRLEKYVTLLQELERHMED 396
+L Q +DE F E + AS P + L++ L KP R+ +Y L++ + + +
Sbjct: 1311 GAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPE 1370
Query: 397 THPDHQDILKAIVAFKTLMGQCQDLRKRKQ 426
+H DH + A+ + L Q + + K+
Sbjct: 1371 SHADHSSLKLALERAEELCSQVNEGVREKE 1400
Score = 55.8 bits (133), Expect = 1e-07
Identities = 32/75 (42%), Positives = 42/75 (56%), Gaps = 4/75 (5%)
Query: 157 ENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTR--VEEGGWWEGTLNGRTGWFPSNYV 214
E S + +A + F+ N DE+S GDII V V E GW G+ G GWFP NYV
Sbjct: 754 ETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 813
Query: 215 REIKSS--ERPLSPK 227
++ SS E+ +SPK
Sbjct: 814 EKMPSSENEKAVSPK 828
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 8/80 (10%)
Query: 142 TVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGT 201
+VS + Q + VE L +A ++ ++ L+ K DII V +E WW G
Sbjct: 887 SVSPIHGQGQVVE-------NLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGE 938
Query: 202 LNGRTGWFPSNYVREIKSSE 221
++G GWFP +YV+ I SE
Sbjct: 939 VHGGRGWFPKSYVKIIPGSE 958
Score = 42.0 bits (97), Expect = 0.002
Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 167 ARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVR 215
A + + +L+ +G+ I VT+ ++G WW G++ R+G FPSNYV+
Sbjct: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVK 1035
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/58 (29%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 174 TNEDELSVCKGDIIYVTRVEEGGWWEGTLNGR-----TGWFPSNYVREIKSSERPLSP 226
+ ++LS+ G +I + + GWW+G L R GWFP+++V+ + S +P
Sbjct: 1067 SGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATP 1124
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 89.7 bits (221), Expect = 9e-18
Identities = 90/353 (25%), Positives = 158/353 (44%), Gaps = 25/353 (7%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNN--NLSTVEVTSLLGNFEEVCTFQQTLCQA 302
V + I++TE+ Y ++L+S++ YL PL LS +V +L N E++ F L +
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
Query: 303 LEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHS--DELEQFMENQG 360
LE S + + C + F +Y YC N+PS++ +L + S +++ +
Sbjct: 166 LENSS----SAGGIAECFVQRSEDF-DIYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
Query: 361 ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMED--THPDHQDILKAIVAFKTLMGQC 418
A L L + L KP R+ KY LLQEL +H + + + +AIV+ +
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
Query: 419 QDLRKRKQ--LELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKE--ERYLMLF 474
D++++++ LQ + + W G ++ G ++ G ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
Query: 475 SNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTV--ERIVVHCNN 532
S +L++ A R + Y+G I V+ E + F+++ T+ R ++ N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
Query: 533 NQDFQEWLEQLNRLI--RGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPP 583
++ + W+ L RL PAS + +K S H + S PL PP
Sbjct: 396 QEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSK-PVLEPLTPP 447
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 89.4 bits (220), Expect = 1e-17
Identities = 83/366 (22%), Positives = 157/366 (42%), Gaps = 28/366 (7%)
Query: 178 ELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPL--SPKAVKGFETA 235
EL+ GD+I V WW G ++ GWFP+++VR + E + P V+
Sbjct: 26 ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLD 85
Query: 236 PLT------------KNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNL-STVEV 282
P + V+ I+ TE+ Y K L+ + YL+ + ++ S ++
Sbjct: 86 PNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQL 145
Query: 283 TSLLGNFEEVCTFQQTLCQALE-ECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSA 341
+ GN E++ FQ + LE + + + ++G C L F +Y YC NH A
Sbjct: 146 KVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNHLDA 204
Query: 342 VNVLTQ--HSDELEQFMENQGASSPGI-LILTTNLSKPFMRLEKYVTLLQELERHMEDTH 398
L++ + F E I + + L P ++ KY L EL ++ H
Sbjct: 205 CMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDH 264
Query: 399 PDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGN-VIFMS 454
D++ + A+ + + Q + RKR+ + +++ + WEGEDI + + +I+
Sbjct: 265 SDYRYVAAALAVMRNVTQQINE-RKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTG 323
Query: 455 QVMVQYGACEEKEERYLMLFSNVLIMLSAS-PRMSGFIYQGKIPIAGTVVTRLDEIEGND 513
++ Y ++R LF + +++ R Y+G+I + V ++ +G D
Sbjct: 324 EMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIE--DGRD 381
Query: 514 CTFEIT 519
F ++
Sbjct: 382 DDFNVS 387
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 87.0 bits (214), Expect = 6e-17
Identities = 74/304 (24%), Positives = 136/304 (44%), Gaps = 31/304 (10%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQS------NNNLSTVEVTSLLGNFEEVCTFQQT 298
VL + TE++Y L+ L+ +L + + N++ V L N E++ +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 299 LCQALEEC-SKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSD--ELEQF 355
+ +EEC P Q +VG C L F+ +Y YC+NH A +L + + + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 356 MEN---QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
+ N G + L L P R+ KY +L+EL + H D+ +++A+ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 413 TLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEER 469
+ + KR+ +L++L E I+ WEG +I + + M V+++ + +ER
Sbjct: 206 AVCSNINE-AKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISS-GNIQER 263
Query: 470 YLMLFSNVLIML----------SASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEIT 519
LF N+L+ AS ++++G+I T V ++ ++ F +
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI---NTEVMEVENVDDGTADFHSS 320
Query: 520 GNTV 523
G+ V
Sbjct: 321 GHIV 324
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 87.0 bits (214), Expect = 6e-17
Identities = 74/304 (24%), Positives = 136/304 (44%), Gaps = 31/304 (10%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQS------NNNLSTVEVTSLLGNFEEVCTFQQT 298
VL + TE++Y L+ L+ +L + + N++ V L N E++ +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 299 LCQALEEC-SKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSD--ELEQF 355
+ +EEC P Q +VG C L F+ +Y YC+NH A +L + + + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 356 MEN---QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
+ N G + L L P R+ KY +L+EL + H D+ +++A+ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 413 TLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEER 469
+ + KR+ +L++L E I+ WEG +I + + M V+++ + +ER
Sbjct: 206 AVCSNINE-AKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISS-GNIQER 263
Query: 470 YLMLFSNVLIML----------SASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEIT 519
LF N+L+ AS ++++G+I T V ++ ++ F +
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI---NTEVMEVENVDDGTADFHSS 320
Query: 520 GNTV 523
G+ V
Sbjct: 321 GHIV 324
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 86.3 bits (212), Expect = 1e-16
Identities = 56/194 (28%), Positives = 93/194 (47%), Gaps = 16/194 (8%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALE 304
V+Q ++DTEK Y K+L L YL PLQ+ L+ E+ SL G+ E+ FQ+ + LE
Sbjct: 28 VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLE 87
Query: 305 E-------------CSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
+ S+F + +GG L HFK +Y +CANH VL + +
Sbjct: 88 DGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTD 146
Query: 352 --LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV 409
+ F++ + + L + L KP R+ KY LL+EL + +H + +A+
Sbjct: 147 KAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 206
Query: 410 AFKTLMGQCQDLRK 423
A + + +++K
Sbjct: 207 AMEKVASHINEMQK 220
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 86.3 bits (212), Expect = 1e-16
Identities = 56/194 (28%), Positives = 93/194 (47%), Gaps = 16/194 (8%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALE 304
V+Q ++DTEK Y K+L L YL PLQ+ L+ E+ SL G+ E+ FQ+ + LE
Sbjct: 1103 VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLE 1162
Query: 305 E-------------CSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
+ S+F + +GG L HFK +Y +CANH VL + +
Sbjct: 1163 DGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTD 1221
Query: 352 --LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV 409
+ F++ + + L + L KP R+ KY LL+EL + +H + +A+
Sbjct: 1222 KAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 1281
Query: 410 AFKTLMGQCQDLRK 423
A + + +++K
Sbjct: 1282 AMEKVASHINEMQK 1295
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 85.5 bits (210), Expect = 2e-16
Identities = 72/326 (22%), Positives = 149/326 (45%), Gaps = 52/326 (15%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS----LLGNFEEVCTFQQTLC 300
++ ++ TEK Y ++L+ + TYL + S + + + GN +E+ F +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 301 QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE-LEQFMENQ 359
L+E K+ + VG C ++ F+ MY+ YC N P + ++ +H+ ++ +
Sbjct: 1356 --LKELEKYEQLPEDVGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQRH 1412
Query: 360 GASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVA--------- 410
G ++ +++ L KP R+ KY LL+EL E+ + +D L+ +++
Sbjct: 1413 GLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAM 1468
Query: 411 -FKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEER 469
L G +++ + +L IL E Q W+ + + G ER
Sbjct: 1469 HLSMLEGFDENIESQGEL---ILQESFQVWDPKTLIRKG------------------RER 1507
Query: 470 YLMLFSNVLIM---LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEI----TGNT 522
+L LF L+ + S S ++Y+ K+ + VT + +EG+ C F + T +
Sbjct: 1508 HLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVT--EHVEGDPCKFALWVGRTPTS 1565
Query: 523 VERIVVHCNNNQDFQEWLEQLNRLIR 548
+IV+ ++ ++ Q+W++ + +I+
Sbjct: 1566 DNKIVLKASSIENKQDWIKHIREVIQ 1591
Score = 83.6 bits (205), Expect = 7e-16
Identities = 71/327 (21%), Positives = 149/327 (45%), Gaps = 31/327 (9%)
Query: 233 ETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS--LLGNFE 290
+++ L + +Y VLQ +++TE++Y ++L ++ Y+ ++ + ++ + GN
Sbjct: 1963 KSSSLKRRHY--VLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIH 2020
Query: 291 EVCTFQQTLCQA-LEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHS 349
++ + + LE+C + PE G L MY+AYC N P + ++++++
Sbjct: 2021 QIYDWHRDFFLGELEKCLEDPEKL----GSLFVKHERRLHMYIAYCQNKPKSEHIVSEYI 2076
Query: 350 DELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV 409
D F E+ L LT L KP R+ KY LL++ ++ + D ++ +A+
Sbjct: 2077 DT---FFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVE 2133
Query: 410 AFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMV---QYGACEEK 466
+ +C D+ +L Q ++G+ + G ++ +V G
Sbjct: 2134 VMCIVPRRCNDMMNVGRL---------QGFDGKIVAQ-GKLLLQDTFLVTDQDAGLLPRC 2183
Query: 467 EERYLMLFSNVLIMLSASPRMSGFIYQG---KIPIAGTVVTRLDEIEGNDCTFEI---TG 520
ER + LF ++I + GF G K I + + + +E + C F + TG
Sbjct: 2184 RERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTG 2243
Query: 521 NTVERIVVHCNNNQDFQEWLEQLNRLI 547
+ VE ++H ++ Q W+ ++N+++
Sbjct: 2244 DVVETFILHSSSPSVRQTWIHEINQIL 2270
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 84.7 bits (208), Expect = 3e-16
Identities = 73/323 (22%), Positives = 144/323 (44%), Gaps = 46/323 (14%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS----LLGNFEEVCTFQQTLC 300
++ +L TEK Y ++L L TYL + S + + + GN +E+ F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNI- 1343
Query: 301 QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE-LEQFMENQ 359
L+E K+ + VG C ++ F+ MY+ YC N P + ++ +H+ ++ +
Sbjct: 1344 -FLKELEKYEQLPEDVGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQRH 1401
Query: 360 GASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQ 419
G ++ +++ L KP R+ KY LL+EL E+ + +D L+ +++
Sbjct: 1402 GLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
Query: 420 DLRK----RKQLELQ---ILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLM 472
+ + L++Q IL + Q W+ + + G ER+L
Sbjct: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHLF 1499
Query: 473 LFSNVLIMLSASPRMSG---FIYQGKIPIAGTVVTRLDEIEGNDCTFEI----TGNTVER 525
LF L+ SG ++Y+ K+ + VT + +EG+ C F + T ++ +
Sbjct: 1500 LFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVT--EHVEGDPCKFALWSGRTPSSDNK 1557
Query: 526 IVVHCNNNQDFQEWLEQLNRLIR 548
V+ +N + QEW++ + +I+
Sbjct: 1558 TVLKASNIETKQEWIKNIREVIQ 1580
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/367 (20%), Positives = 151/367 (41%), Gaps = 44/367 (11%)
Query: 194 EGGWWEGTLNGRTGWFPSNYVREI--KSSERPLSPKAVKGFETAPLTKNYYTVVLQNILD 251
EG + G+L G K+ E KA++G VL ++
Sbjct: 1890 EGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRG----------RMFVLNELVQ 1939
Query: 252 TEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS--LLGNFEEVCTFQQTLCQALEECSKF 309
TEK+Y K+L ++ +++ ++ + + GN ++ + + L E K
Sbjct: 1940 TEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFF--LAELEKC 1997
Query: 310 PENQHKVGGCLLSLMPHFKSM--YLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGIL 367
+ Q ++ + H + + Y+ YC N P + ++ ++ E+ + L
Sbjct: 1998 IQEQDRLAQLFIK---HERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQR----L 2050
Query: 368 ILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQL 427
L+ L KP R+ KY LL++ R+ E + DI KA+ + +C D+ +L
Sbjct: 2051 TLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRL 2110
Query: 428 ELQILSEPIQAWEGEDIKNLGNVIFMSQ---VMVQYGACEEKEERYLMLFSNVLI---ML 481
Q +EG + G ++ + + G +ER + LF ++I +L
Sbjct: 2111 ---------QGFEG-TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL 2160
Query: 482 SASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITG-NTVERIVVHCNNNQDFQEWL 540
G++++ I + V+ + ++ + C F + T ER+V+ N Q W+
Sbjct: 2161 RKGSLTPGYMFKRSIKMNYLVLE--ENVDNDPCKFALMNRETSERVVLQAANADIQQAWV 2218
Query: 541 EQLNRLI 547
+ +N+++
Sbjct: 2219 QDINQVL 2225
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 84.7 bits (208), Expect = 3e-16
Identities = 73/323 (22%), Positives = 144/323 (44%), Gaps = 46/323 (14%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS----LLGNFEEVCTFQQTLC 300
++ +L TEK Y ++L L TYL + S + + + GN +E+ F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNI- 1343
Query: 301 QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE-LEQFMENQ 359
L+E K+ + VG C ++ F+ MY+ YC N P + ++ +H+ ++ +
Sbjct: 1344 -FLKELEKYEQLPEDVGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQRH 1401
Query: 360 GASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQ 419
G ++ +++ L KP R+ KY LL+EL E+ + +D L+ +++
Sbjct: 1402 GLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
Query: 420 DLRK----RKQLELQ---ILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLM 472
+ + L++Q IL + Q W+ + + G ER+L
Sbjct: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHLF 1499
Query: 473 LFSNVLIMLSASPRMSG---FIYQGKIPIAGTVVTRLDEIEGNDCTFEI----TGNTVER 525
LF L+ SG ++Y+ K+ + VT + +EG+ C F + T ++ +
Sbjct: 1500 LFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVT--EHVEGDPCKFALWSGRTPSSDNK 1557
Query: 526 IVVHCNNNQDFQEWLEQLNRLIR 548
V+ +N + QEW++ + +I+
Sbjct: 1558 TVLKASNIETKQEWIKNIREVIQ 1580
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 77.4 bits (189), Expect = 5e-14
Identities = 128/571 (22%), Positives = 224/571 (39%), Gaps = 104/571 (18%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEF--LKSSLKNGVVLCKLINRLMPGSV--EKF 56
M P +Q WLI VL + + D + L +L++GV+LC+L+N L S+ ++
Sbjct: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
Query: 57 CLDPQ-TEADCINNINDFLKGCATL----QVEIFDPDDLYSGVNFSKVLSTLLAVNKATE 111
L PQ ++ C+ NI FL C + E+F+ DL+ +F KV+ TL
Sbjct: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETL-------- 112
Query: 112 DQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNF 171
+LS P ++ + T +S E G LI +
Sbjct: 113 SRLSRTPIALATGIRPFPT-----------------EESINDEDIYKGLPDLIDETLVE- 154
Query: 172 KQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKG 231
+E++L C V +EGG ++ +E PK +
Sbjct: 155 ---DEEDLYDC------VYGEDEGG---------------EVYEDLMKAEEAHQPKCPE- 189
Query: 232 FETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEE 291
+ + L I TE++Y + L+S+ ++ PL+ L+ E S+ N E
Sbjct: 190 -------NDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLK--RFLTAAEFDSVFINIPE 240
Query: 292 VCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKS---MYLAYCANHPSAVNVLTQH 348
+ + L Q + + +Q+ L + ++K +Y YC+ SA++ L
Sbjct: 241 LVKLHRNLMQEIHDSIVNKNDQN-----LYQVFINYKERLVIYGQYCSGVESAISSLDYI 295
Query: 349 SDELE----QFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDI 404
S E + E ++ G L L P R+ KY LLQEL +H D P +
Sbjct: 296 SKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTD--PTEKAN 353
Query: 405 LK-AIVAFKTLMGQCQDLR---------KRKQLELQILSEPIQAWEGEDIKNLGNVIFMS 454
LK A+ A K L +++ K+ QL ++ L++P+ + G
Sbjct: 354 LKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLF--------GRPQGDG 405
Query: 455 QVMVQYGACEEKEERYLMLFSNVLIMLSA---SPRMSGFIYQGKIPIAGTVVTRLDEIEG 511
++ + K+ER++ LF +I+ + M I + IA T + +
Sbjct: 406 EIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKW 465
Query: 512 NDCTFEITGNTVERIVVHCNNNQDFQEWLEQ 542
+ + I + +C ++WLEQ
Sbjct: 466 SYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ 496
Score = 60.5 bits (145), Expect = 6e-09
Identities = 26/54 (48%), Positives = 36/54 (66%), Gaps = 1/54 (1%)
Query: 164 IVKARFNFKQTNEDELSVCKGDIIYV-TRVEEGGWWEGTLNGRTGWFPSNYVRE 216
I AR++F + ELS+ KGD++ + T++ GWW G +NGR GWFPS YV E
Sbjct: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 845
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 76.6 bits (187), Expect = 8e-14
Identities = 61/229 (26%), Positives = 104/229 (45%), Gaps = 20/229 (8%)
Query: 214 VREIKSSERPLSPKAVKGFETAPLTK----NYYTVVLQNILDTEKEYAKELQSLLVTYLR 269
+ E+ S++ SP+ G + A + + + V+ +L+TE+ Y K+L L+ YL+
Sbjct: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLK 1068
Query: 270 PLQSNNNLSTVEVTSLLGNFEEVCTFQ----QTL---------CQALEECSKFPENQHKV 316
PLQ L+ E+ L GN E+ FQ +TL + LE+ +F + +
Sbjct: 1069 PLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSL 1128
Query: 317 GGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE--LEQFMENQGASSPGILILTTNLS 374
GG L FK +Y A+CA+H VL + + + F++ Q L + L
Sbjct: 1129 GGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLI 1187
Query: 375 KPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRK 423
KP R+ KY LL+EL + +H + AI + +++K
Sbjct: 1188 KPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQK 1236
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 74.3 bits (181), Expect = 4e-13
Identities = 75/339 (22%), Positives = 149/339 (43%), Gaps = 19/339 (5%)
Query: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVE---VTSLLGNFEEVCTFQQTLCQ 301
V +LDTE+ Y + L++L+ Y++PL+ N + V + E+ + +
Sbjct: 1070 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLE 1129
Query: 302 ALEECSKFPENQHKVGGCLLS-----LMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFM 356
+ C + Q KVG L+ ++ + S Y+ N AV V + +F+
Sbjct: 1130 QVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFL 1189
Query: 357 ENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMG 416
E + L+ + KP R+ +Y L+++L +H + HPDH +L+A K +
Sbjct: 1190 EQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAE 1249
Query: 417 QC-QDLRKRKQLE--LQILSEPIQAWEG-EDIKNLGNVIFMSQVMVQYGACEEKEERYLM 472
+ + +R ++ E ++L E EG ED++ +++++ A K++R L
Sbjct: 1250 RINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLF 1309
Query: 473 LFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERI--VVHC 530
LF++ LI+ + R SG + + + + T + +D +++ + I
Sbjct: 1310 LFTD-LIVCTTLKRKSGSLRRSSMSLY-TAASVIDTASKYKMLWKLPLEDADIIKGASQA 1367
Query: 531 NNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSS 569
N ++ Q + ++RL + +SK S S H S
Sbjct: 1368 TNRENIQ---KAISRLDEDLTTLGQMSKLSESLGFPHQS 1403
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 71.6 bits (174), Expect = 3e-12
Identities = 124/517 (23%), Positives = 208/517 (40%), Gaps = 92/517 (17%)
Query: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEF---LKSSLKNGVVLCKLINRLMPGSVEKFC 57
M Q WLI VL P + P L +L++GV+LC+L++ L PGS++
Sbjct: 1 MEQWRQCGRWLIDCKVLP-PNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKD 59
Query: 58 LD--PQ-TEADCINNINDFLKGC----ATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKAT 110
++ PQ ++ C+ NI FLK C E+FDP DL+ +F KV+S +
Sbjct: 60 INFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAV------- 112
Query: 111 EDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFN 170
S LS + +Q G+ R + E TEN R
Sbjct: 113 ------------SRLSLHSIAQN----------KGI-RPFPSEETTENDDDVY----RSL 145
Query: 171 FKQTNEDELSVCKGDIIYVTRVEEGG--WWEGTLNGRTGWFPSNYVREIKSSERPLSPKA 228
+ +E +L DI E+GG +E + Y++++ +E
Sbjct: 146 EELADEHDLG---EDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCC 202
Query: 229 VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGN 288
+ E YY + + D EK Y L+ + LS ++ ++ N
Sbjct: 203 L--LEIQETEAKYY----RTLEDIEKNYMSPLRLV-------------LSPADMAAVFIN 243
Query: 289 FEEVCTFQQTLCQALEECSKFPENQHKVGGCLLS-LMPHFKS---MYLAYCANHPSAVNV 344
E++ + +A++ VGG L+ + FK +Y YC++ A N
Sbjct: 244 LEDLIKVHHSFLRAIDV-------SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT 296
Query: 345 LTQHSDELEQFMENQGASS----PGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPD 400
L Q E F + + G L L P R+ KY LL+EL H + P+
Sbjct: 297 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPE 355
Query: 401 HQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIK--NLGNVIFMSQVMV 458
Q + +A+ A + L ++++ K+ L+ +SE + E +K G ++ V
Sbjct: 356 RQQLKEALEAMQDLAMYINEVKRDKE-TLRKISEFQSSIENLQVKLEEFGRPKIDGELKV 414
Query: 459 QYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGK 495
+ K++RYL LF V+I+ + G+ Y+ K
Sbjct: 415 RSIVNHTKQDRYLFLFDKVVIVC----KRKGYSYELK 447
Score = 56.6 bits (135), Expect = 9e-08
Identities = 40/124 (32%), Positives = 65/124 (52%), Gaps = 11/124 (8%)
Query: 98 KVLSTLLAVNKATEDQLSERPCGRS-SSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMT 156
K L T L + ++ + R RS +S ++ N S +PQG ++ Q +
Sbjct: 757 KQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFAS------QGPSAPFW 810
Query: 157 ENGSHQLI--VKARFNFKQTNEDELSVCKGDIIYV-TRVE-EGGWWEGTLNGRTGWFPSN 212
+ ++I AR+NF + ELS+ +GD++ + +R+ + GWW+G NGR GWFPS
Sbjct: 811 SVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPST 870
Query: 213 YVRE 216
YV E
Sbjct: 871 YVEE 874
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 70.5 bits (171), Expect = 6e-12
Identities = 81/346 (23%), Positives = 143/346 (41%), Gaps = 15/346 (4%)
Query: 214 VREIKSSERPLSPKAV-KGFETAPLTKNYYTVVLQNILDTEKEYAKELQSL-LVTYLRPL 271
V+E ++ E PL + + + E + + +L TE+ Y L L V Y + L
Sbjct: 178 VQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLL 237
Query: 272 QSNNNLS--TVEVTSLLGNFEEVCTFQQT-LCQALEECSKFPENQHKVGGCLLSLMPHFK 328
+ N S V + N + F L LE+ + E ++G L L P K
Sbjct: 238 EEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLK 297
Query: 329 SMYLAYCANHPSAVNVLTQHSDELEQFM----ENQGASSPGILILTTNLSKPFMRLEKYV 384
MY Y +A+ ++ ++ + QF E Q G L L ++ +P R+ +Y
Sbjct: 298 -MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYE 356
Query: 385 TLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDI 444
LL++ R + D D K++ T ++ + ++L E EDI
Sbjct: 357 MLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDI 416
Query: 445 KNLGN-VIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSG--FIYQGKIPIAGT 501
N N +I Q++ +ERYL LF+N+L+ + G F + ++ I G
Sbjct: 417 VNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGM 476
Query: 502 VVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLI 547
+ E TF+++G + + ++ QD +EW++ L I
Sbjct: 477 KIVETQN-EEYPHTFQVSGKE-RTLELQASSAQDKEEWIKALQETI 520
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 70.1 bits (170), Expect = 7e-12
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 19/267 (7%)
Query: 330 MYLAYCANHPSAVNVLTQHSDELEQ--FMENQGASSPGILILTTNLSKPFMRLEKYVTLL 387
+Y YC N+P++V LT+ + +Q F ++ L L + L KP R+ KY LL
Sbjct: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLL 182
Query: 388 QELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQ--LELQILSEPIQAWEGEDIK 445
QE+ +H ++ + + AI + D+++R + + LQ + + W+G D+
Sbjct: 183 QEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLT 242
Query: 446 NLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTR 505
G ++ V + ER LF L++ R F+Y+G IP + +
Sbjct: 243 TYGELVLEGTFRVH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSLM--- 293
Query: 506 LDEIEGNDCTFEIT--GNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSS 563
L E + F +T ++ ++ + ++ + W + RLI + K +
Sbjct: 294 LIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAI 353
Query: 564 CSAHSSFSSTGQPRGPLEPPQIIKPWS 590
S + + R P ++ K WS
Sbjct: 354 LEMDSYYPN----RYRCSPERLKKAWS 376
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/128 (34%), Positives = 67/128 (52%), Gaps = 7/128 (5%)
Query: 169 FNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSER--PLSP 226
F+++ ++DEL++ G+II R E+GGWWEG +NGR G FP N+VREIK + PL+
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 227 KA-VKGFETAPLTKNYYTVVLQNILDTEK--EYAKELQSLLVTYLRPLQSNNNLSTVEVT 283
KA K P + + + IL T K E + + +YL L ++
Sbjct: 68 KAPEKPLHEVPSGNSLLS--SETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125
Query: 284 SLLGNFEE 291
++G EE
Sbjct: 126 EVVGEVEE 133
Score = 68.2 bits (165), Expect = 3e-11
Identities = 42/118 (35%), Positives = 60/118 (50%), Gaps = 22/118 (18%)
Query: 107 NKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVK 166
NKA E L E P G +S LS+ +TN +G +R+ + ++
Sbjct: 67 NKAPEKPLHEVPSG-NSLLSSETILRTNKRG---------ERRRRRCQVA---------- 106
Query: 167 ARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPL 224
F++ N+DEL + GDII V E GWWEG LNG+TG FPSN+++E+ L
Sbjct: 107 --FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDEL 162
Score = 56.2 bits (134), Expect = 1e-07
Identities = 30/84 (35%), Positives = 44/84 (52%), Gaps = 7/84 (8%)
Query: 150 SKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVE--EGGWWEGTLNGRTG 207
S EM + K F ++ N+DEL++ +GDI+ + + + GWWEG LNGR G
Sbjct: 257 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG 316
Query: 208 WFPSNYVREI-----KSSERPLSP 226
FP N+V+ + K RP P
Sbjct: 317 VFPDNFVKLLPPDFEKEGNRPKKP 340
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,680,963
Number of Sequences: 37866
Number of extensions: 1357946
Number of successful extensions: 6891
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 219
Number of HSP's successfully gapped in prelim test: 372
Number of HSP's that attempted gapping in prelim test: 5699
Number of HSP's gapped (non-prelim): 1391
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.