Search of human proteins with 219842244

Search of human proteins with 219842244

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219842244 periphilin 1 isoform 6 [Homo sapiens]
         (434 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219842244 periphilin 1 isoform 6 [Homo sapiens]                    880   0.0  
gi|48255929 periphilin 1 isoform 1 [Homo sapiens]                     752   0.0  
gi|41872349 periphilin 1 isoform 4 [Homo sapiens]                     577   e-165
gi|41872344 periphilin 1 isoform 3 [Homo sapiens]                     528   e-150
gi|41872368 periphilin 1 isoform 2 [Homo sapiens]                     528   e-150
gi|219842250 periphilin 1 isoform 8 [Homo sapiens]                    525   e-149
gi|41872339 periphilin 1 isoform 5 [Homo sapiens]                     504   e-143
gi|219842247 periphilin 1 isoform 7 [Homo sapiens]                    476   e-134
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          49   1e-05
gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]     48   2e-05
gi|50083281 KIAA1853 protein [Homo sapiens]                            47   4e-05
gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapi...    46   8e-05
gi|15055543 splicing factor, arginine/serine-rich 2B [Homo sapiens]    45   1e-04
gi|62526045 zinc finger protein 638 [Homo sapiens]                     44   2e-04
gi|21626468 zinc finger protein 638 [Homo sapiens]                     44   2e-04
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     42   8e-04
gi|52426743 cisplatin resistance-associated overexpressed protei...    42   8e-04
gi|19923485 cisplatin resistance-associated overexpressed protei...    42   8e-04
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    42   0.001
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    42   0.001
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...    42   0.001
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        42   0.001
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]     41   0.002
gi|221139764 PHD and ring finger domains 1 [Homo sapiens]              41   0.002
gi|189011568 adenomatous polyposis coli [Homo sapiens]                 41   0.002
gi|189011566 adenomatous polyposis coli [Homo sapiens]                 41   0.002
gi|53759122 adenomatous polyposis coli [Homo sapiens]                  41   0.002
gi|197313748 SET domain containing 2 [Homo sapiens]                    41   0.002
gi|24762236 PRP38 pre-mRNA processing factor 38 (yeast) domain c...    41   0.002
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    40   0.005

>gi|219842244 periphilin 1 isoform 6 [Homo sapiens]
          Length = 434

 Score =  880 bits (2273), Expect = 0.0
 Identities = 434/434 (100%), Positives = 434/434 (100%)

Query: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60
           MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH
Sbjct: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60

Query: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120
           YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP
Sbjct: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120

Query: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
           GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK
Sbjct: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180

Query: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 240
           WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA
Sbjct: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 240

Query: 241 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVR 300
           SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVR
Sbjct: 241 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVR 300

Query: 301 NTEMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAPQ 360
           NTEMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAPQ
Sbjct: 301 NTEMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAPQ 360

Query: 361 PLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVV 420
           PLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVV
Sbjct: 361 PLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVV 420

Query: 421 HCNSRKDVKPENKQ 434
           HCNSRKDVKPENKQ
Sbjct: 421 HCNSRKDVKPENKQ 434


>gi|48255929 periphilin 1 isoform 1 [Homo sapiens]
          Length = 458

 Score =  752 bits (1941), Expect = 0.0
 Identities = 383/421 (90%), Positives = 383/421 (90%), Gaps = 33/421 (7%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 73
           R   PP  H  DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT
Sbjct: 71  RRSGPP--HRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 128

Query: 74  FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 133
           FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE
Sbjct: 129 FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 188

Query: 134 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 193
           RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN
Sbjct: 189 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 248

Query: 194 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 253
           LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD
Sbjct: 249 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 308

Query: 254 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENE 313
           CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENE
Sbjct: 309 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENE 368

Query: 314 GEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAPQPLQPRKKRVRRTT 373
           GEETAQS                               APQPPQAPQPLQPRKKRVRRTT
Sbjct: 369 GEETAQS-------------------------------APQPPQAPQPLQPRKKRVRRTT 397

Query: 374 QLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENK 433
           QLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENK
Sbjct: 398 QLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENK 457

Query: 434 Q 434
           Q
Sbjct: 458 Q 458


>gi|41872349 periphilin 1 isoform 4 [Homo sapiens]
          Length = 319

 Score =  577 bits (1487), Expect = e-165
 Identities = 286/286 (100%), Positives = 286/286 (100%)

Query: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60
           MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH
Sbjct: 8   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 67

Query: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120
           YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP
Sbjct: 68  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 127

Query: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
           GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK
Sbjct: 128 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 187

Query: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 240
           WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA
Sbjct: 188 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 247

Query: 241 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 286
           SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI
Sbjct: 248 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 293


>gi|41872344 periphilin 1 isoform 3 [Homo sapiens]
          Length = 367

 Score =  528 bits (1361), Expect = e-150
 Identities = 266/273 (97%), Positives = 266/273 (97%), Gaps = 2/273 (0%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 73
           R   PP  H  DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT
Sbjct: 71  RRSGPP--HRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 128

Query: 74  FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 133
           FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE
Sbjct: 129 FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 188

Query: 134 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 193
           RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN
Sbjct: 189 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 248

Query: 194 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 253
           LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD
Sbjct: 249 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 308

Query: 254 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 286
           CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI
Sbjct: 309 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 341


>gi|41872368 periphilin 1 isoform 2 [Homo sapiens]
          Length = 374

 Score =  528 bits (1361), Expect = e-150
 Identities = 266/273 (97%), Positives = 266/273 (97%), Gaps = 2/273 (0%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 73
           R   PP  H  DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT
Sbjct: 78  RRSGPP--HRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 135

Query: 74  FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 133
           FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE
Sbjct: 136 FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 195

Query: 134 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 193
           RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN
Sbjct: 196 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 255

Query: 194 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 253
           LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD
Sbjct: 256 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 315

Query: 254 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 286
           CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI
Sbjct: 316 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 348


>gi|219842250 periphilin 1 isoform 8 [Homo sapiens]
          Length = 293

 Score =  525 bits (1351), Expect = e-149
 Identities = 266/286 (93%), Positives = 267/286 (93%), Gaps = 19/286 (6%)

Query: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60
           MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH
Sbjct: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60

Query: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120
           YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHR     
Sbjct: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHR----- 115

Query: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
                         +KERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK
Sbjct: 116 --------------NKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 161

Query: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 240
           WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA
Sbjct: 162 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 221

Query: 241 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 286
           SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI
Sbjct: 222 SKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 267


>gi|41872339 periphilin 1 isoform 5 [Homo sapiens]
          Length = 258

 Score =  504 bits (1297), Expect = e-143
 Identities = 249/249 (100%), Positives = 249/249 (100%)

Query: 1   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 60
           MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH
Sbjct: 8   MWSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH 67

Query: 61  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120
           YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP
Sbjct: 68  YARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 127

Query: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
           GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK
Sbjct: 128 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 187

Query: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 240
           WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA
Sbjct: 188 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIA 247

Query: 241 SKTKEIEQV 249
           SKTKEIEQV
Sbjct: 248 SKTKEIEQV 256


>gi|219842247 periphilin 1 isoform 7 [Homo sapiens]
          Length = 348

 Score =  476 bits (1225), Expect = e-134
 Identities = 246/273 (90%), Positives = 247/273 (90%), Gaps = 21/273 (7%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 73
           R   PP  H  DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT
Sbjct: 71  RRSGPP--HRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 128

Query: 74  FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 133
           FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHR                  
Sbjct: 129 FFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHR------------------ 170

Query: 134 RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 193
            +KERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN
Sbjct: 171 -NKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESN 229

Query: 194 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 253
           LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD
Sbjct: 230 LPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQD 289

Query: 254 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 286
           CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI
Sbjct: 290 CETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI 322


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 71/288 (24%), Positives = 111/288 (38%), Gaps = 55/288 (19%)

Query: 3   SEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSH-Y 61
           S   Y+     R R+P ++     S   +   D S SR P     RD  R +S   +   
Sbjct: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN--KARDHSRSRSPNKARDR 473

Query: 62  ARERSPYK-RDNTFF---------------------RESPVGRKDSPHSRSGSSV----- 94
           +R RSP K RD++                       R+S    K+  H RS S       
Sbjct: 474 SRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQR 533

Query: 95  -SSRSYSPERSKSYS---FHQSQHRKSVRPGASYKRQNEGNPERDKER-----PVQSLKT 145
             SRS + ER +S S     + +HR+S  P     R+   +P +++ER       +    
Sbjct: 534 RQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDH 593

Query: 146 SRDTSPSSGSAVSSSKVLDKP-----SRLTEKELAEAASKWAAEKLEKSDESNLPEISEY 200
           SR  SP+  S  S  +   K      SR   KE   + S+ ++++ + S +S +P   ++
Sbjct: 594 SRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPS-QSTVPRSPDW 652

Query: 201 EAGSTAPLFTDQPEEPESNTTHGIELF---------EDSQL-TTRSKA 238
           +   T      Q   P   ++H    F         +DSQ   T SKA
Sbjct: 653 KRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 53/202 (26%), Positives = 78/202 (38%), Gaps = 29/202 (14%)

Query: 10  ERIPRERAPPRSHPS-DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPY 68
           ER  R  + PR      +SG    + DHS SR P     R             +R RSPY
Sbjct: 374 ERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR-------------SRSRSPY 420

Query: 69  KRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQN 128
           K  +     SP   +D   SRS      RS S   +K+       H +S  P  +  R  
Sbjct: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKA-----RDHSRSRSPNKARDRSR 475

Query: 129 EGNPERDKER-----PVQSLKTSRDTSPSS----GSAVSSSKVLD-KPSRLTEKELAEAA 178
             +P ++++      P +     R  SPS       + SSSK  D + SR   KE     
Sbjct: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQ 535

Query: 179 SKWAAEKLEKSDESNLPEISEY 200
           S+   ++ ++S   +  E  E+
Sbjct: 536 SRSPNKERDRSQSRSPSEEREH 557



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 40/203 (19%)

Query: 14  RERAPPRSHPSDES-------GYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYA---- 62
           + R+P RS    +         + W R+ HS +R    + +     R S   SH      
Sbjct: 283 QSRSPRRSRSGSQKRTHSRVRSHSWKRN-HSRARSRTRKGILSQMGRHSQSRSHSKGKSQ 341

Query: 63  -RERSPYKRDNTFFRESPVGRKDSPHSRSGS--------------SVSSRSYSPERSKSY 107
            + R+P +  +  +  +P   +   HSRS S              S  S+S SP + + +
Sbjct: 342 NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401

Query: 108 SFHQSQH--RKSVRPGASYK-----RQNEGNPERDKER---PVQSLKTSRDTSPSSGSAV 157
           S  +S +  R   R  + YK     R    N  RD  R   P ++   SR  SP+     
Sbjct: 402 SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDH 461

Query: 158 SSSKVLDKPSRLTEKELAEAASK 180
           S S+    P++  ++  + + SK
Sbjct: 462 SRSR---SPNKARDRSRSRSPSK 481



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 43/172 (25%), Positives = 65/172 (37%), Gaps = 7/172 (4%)

Query: 39  SRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRS 98
           SR+  Y       R KS Y+    R R      +   R S  G +   HSR  S    R+
Sbjct: 252 SREKSYSPTEMSSRVKS-YNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRN 310

Query: 99  YSPERSKSYSFHQSQ---HRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGS 155
           +S  RS++     SQ   H +S R  +  K QN+    R       S   S++ S S   
Sbjct: 311 HSRARSRTRKGILSQMGRHSQS-RSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSR 369

Query: 156 AVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAP 207
             SSSK  D     + ++ +  +   +  K      S  P  +   + S +P
Sbjct: 370 --SSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSP 419


>gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]
          Length = 951

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 50/192 (26%), Positives = 75/192 (39%), Gaps = 8/192 (4%)

Query: 12  IPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRD 71
           +P     P   PS +S      ++    ++   +  R   R   ++SS  +R RS  K  
Sbjct: 730 LPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAK 789

Query: 72  NTFFRESPVGRKDSPHSRSGS-SVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEG 130
           ++     P   +    SRS S S   R++SPER +      + +R S  PGAS KR    
Sbjct: 790 HSL----PSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSR 845

Query: 131 NPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSD 190
           +P   K++       SR  S +   +VS SK             A +AS    E    S 
Sbjct: 846 SPHEKKKK---RRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQ 902

Query: 191 ESNLPEISEYEA 202
           E +     E EA
Sbjct: 903 ERSRGVSQEKEA 914



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 47/181 (25%), Positives = 68/181 (37%), Gaps = 10/181 (5%)

Query: 6   RYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKS-FYSSHYARE 64
           +Y      R R+  ++  S  S YR  R   S SR P  R      RR+     + Y   
Sbjct: 773 KYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVS 832

Query: 65  RSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASY 124
           RSP          SP  +K    SRS +   +RS S   SK         + + RP A  
Sbjct: 833 RSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSK---------QAAPRPAAPA 883

Query: 125 KRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAE 184
                       E    S + SR  S    + +SS+ V    S++T+  +A+  +  AA 
Sbjct: 884 AHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAMLAAS 943

Query: 185 K 185
           K
Sbjct: 944 K 944


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 54/188 (28%), Positives = 76/188 (40%), Gaps = 33/188 (17%)

Query: 3   SEGRYEYERIPR------ERAPPRSHPSDESGYRWTRDDHSASRQPEY-------RDMRD 49
           S  +  Y R P       +R+PP           ++R   S  R P+Y       R+   
Sbjct: 423 SSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERER 482

Query: 50  GFRRKSFYSSHYARER------------SPYKRDNTFFRESP-----VGRKDSPHSRSGS 92
             RR+  YS    R R            S  KR   ++R SP     +    S +S S S
Sbjct: 483 ARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSS 542

Query: 93  SVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPS 152
             +SRSYS  RS+S S  +S+ R S    +S +  + G+  R + R  +S   SR  S S
Sbjct: 543 RSASRSYSRSRSRSRSRRRSRTRTS--SSSSSRSPSPGSRSRSRSRS-RSRSRSRSQSRS 599

Query: 153 SGSAVSSS 160
             SA S S
Sbjct: 600 YSSADSYS 607



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 49/160 (30%), Positives = 65/160 (40%), Gaps = 23/160 (14%)

Query: 16  RAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFF 75
           R+ P    S  S Y  TR    +SR P  R      + +S  S   +  RSP     +  
Sbjct: 382 RSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGK 441

Query: 76  RESPVGRKDSPHSRSGSSVSSRSYSP--ERSKSYSFHQSQHRKSVRPGASYKRQNEGNPE 133
           R  P     S  SRS  S S   YSP  ER   YS   SQ R+  R   + +R+   +P 
Sbjct: 442 RSPP-----SRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERER---ARRRRRSYSPM 493

Query: 134 RDKERPVQS-LKTSRDT------------SPSSGSAVSSS 160
           R + R   S L+  R T            SPSS  ++SS+
Sbjct: 494 RKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSST 533



 Score = 36.2 bits (82), Expect = 0.060
 Identities = 37/110 (33%), Positives = 43/110 (39%), Gaps = 18/110 (16%)

Query: 12  IPRERAPPRSHPSDESGYRW--TRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK 69
           IP  R  P S  S  S   W  +    SASR                YS   +R RS  +
Sbjct: 517 IPYYRPSPSSSGSLSSTSSWYSSSSSRSASRS---------------YSRSRSRSRSR-R 560

Query: 70  RDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVR 119
           R  T    S   R  SP SRS S   SRS S  RS+S S+  +    S R
Sbjct: 561 RSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSYSSTR 610



 Score = 32.3 bits (72), Expect = 0.86
 Identities = 49/213 (23%), Positives = 76/213 (35%), Gaps = 29/213 (13%)

Query: 7   YEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERS 66
           +E ++  RE    R H +       T    S  ++ + +  R   RR S YS       S
Sbjct: 77  WERDKTCRELGATRGHSASHDK-DLTPPPSSRGKKKKKKSTRKKRRRSSSYSP------S 129

Query: 67  PYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVR--PGASY 124
           P K+           +    H R  S    R +S    KS    + +H+K  R  P  S+
Sbjct: 130 PVKKKKK--------KSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSH 181

Query: 125 KRQNEGNPER---DKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKW 181
           + ++   P R    + RP       R  SP  G      K   + SR   K L + + + 
Sbjct: 182 RHRHHRCPSRSQSSESRPSSCESRHRGRSPEEG-----QKSRRRHSRRCSKTLCKDSPEA 236

Query: 182 AAEKLEKSDESNLPEISE----YEAGSTAPLFT 210
            + +        L  +S       +GS A LFT
Sbjct: 237 QSSRPPSQPLQMLGYLSARGVITGSGSAADLFT 269


>gi|133922600 splicing factor, arginine/serine-rich 16 [Homo
           sapiens]
          Length = 674

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 58/206 (28%), Positives = 77/206 (37%), Gaps = 29/206 (14%)

Query: 2   WSEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHY 61
           WS  R    R  R R+  R H    S     RD H  SR P  R    G RR+S   SH 
Sbjct: 422 WSRSRSRSRRYSRSRSRGRRHSGGGS-----RDGHRYSRSPARRGGY-GPRRRSRSRSHS 475

Query: 62  ARERSPYKRDNTFFRESPVGRKDSPHS----RSGSSVSSRSYSPERSKSYSFHQSQ---- 113
                 Y+R     R     R  S  S    RS S   SRS+SP  S+S S  +S+    
Sbjct: 476 GDR---YRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSP 532

Query: 114 -----HRKSVRPGAS---YKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDK 165
                  K  RP AS    ++  +  P   KE      K     +P     +   K L++
Sbjct: 533 SPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPK----LTPQEKLKLRMQKALNR 588

Query: 166 PSRLTEKELAEAASKWAAEKLEKSDE 191
             +  +K   E   +   E+ E+ DE
Sbjct: 589 QFKADKKAAQEKMIQQEHERQEREDE 614



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 59/207 (28%), Positives = 81/207 (39%), Gaps = 24/207 (11%)

Query: 11  RIPRERAPPRSHPSDESGYRWTRDD-HSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK 69
           R    R+  RS      G  + R   H+ SR   +   R   RR S   S   R      
Sbjct: 388 RTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGS 447

Query: 70  RDNTFFRESPVGRKD-SPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQN 128
           RD   +  SP  R    P  RS     SRS+S +R +       +H  S R  +S+    
Sbjct: 448 RDGHRYSRSPARRGGYGPRRRS----RSRSHSGDRYRR-GGRGLRHHSSSRSRSSWSL-- 500

Query: 129 EGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDK---PSRLTEKELAEAASKWAAEK 185
             +P R +     SL  SR  SPS   + S S+   +   PS   EK    AAS    EK
Sbjct: 501 --SPSRSR-----SLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEK 553

Query: 186 LEKSDESNLPEISEYEAGSTAPLFTDQ 212
           L+K++ +     +  E G+  P  T Q
Sbjct: 554 LKKTEPA-----AGKETGAAKPKLTPQ 575


>gi|15055543 splicing factor, arginine/serine-rich 2B [Homo sapiens]
          Length = 282

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 47/154 (30%), Positives = 59/154 (38%), Gaps = 27/154 (17%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNT 73
           R R+P R H S   G   +R   S SR    R  R  + R  +  S Y+R  SPY R   
Sbjct: 124 RSRSPRRRHRSRSRGPSCSRS-RSRSRYRGSRYSRSPYSRSPYSRSRYSR--SPYSRSR- 179

Query: 74  FFRESPVG-----------------RKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRK 116
            +RES  G                      HS+SGSS SSRS S  +S S     ++  K
Sbjct: 180 -YRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSS-----ARRSK 233

Query: 117 SVRPGASYKRQNEGNPERDKERPVQSLKTSRDTS 150
           S     S  R    +  R   R  +    SR  S
Sbjct: 234 SSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRS 267



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 44/146 (30%), Positives = 59/146 (40%), Gaps = 15/146 (10%)

Query: 3   SEGRYE---YERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSS 59
           S  RY    Y R P  R+P        S  R++R  +S SR  E R     +    + +S
Sbjct: 146 SRSRYRGSRYSRSPYSRSP-------YSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNS 198

Query: 60  HYAR---ERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRK 116
            Y+R    RS  K  ++    S    K S   RS SS  SRS S  RS S +  +S  R 
Sbjct: 199 RYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMT--RSPPRV 256

Query: 117 SVRPGASYKRQNEGNPERDKERPVQS 142
           S R   S  R        ++E  + S
Sbjct: 257 SKRKSKSRSRSKRPPKSPEEEGQMSS 282



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 45/180 (25%), Positives = 66/180 (36%), Gaps = 19/180 (10%)

Query: 30  RWTRDDHSASRQ--PEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPH 87
           R+ R D   SRQ  P  R    G+ R+S   S+  R RSP +R                 
Sbjct: 91  RYGRRDLPRSRQGEPRGRSRGGGYGRRS--RSYGRRSRSPRRRHR--------------- 133

Query: 88  SRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSR 147
           SRS     SRS S  R +   + +S + +S    + Y R         + R   S  +S 
Sbjct: 134 SRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSS 193

Query: 148 DTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAP 207
             S S  S   SS+   K    T    A  +   +A + + S  S     S   + + +P
Sbjct: 194 GYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSP 253


>gi|62526045 zinc finger protein 638 [Homo sapiens]
          Length = 1978

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 63/233 (27%), Positives = 86/233 (36%), Gaps = 40/233 (17%)

Query: 3   SEGRYEYERIPRERA----PPRSHPSDESG-YRWTRDDHSASRQPEYRDMRDGFRRKSFY 57
           +EG  +    PR R+    P RS  S  S  +R +R       +P  R  R   R  S Y
Sbjct: 474 NEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRY 533

Query: 58  SSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKS 117
            S  +R RSPY+  N F                GS    RS SPER    S   S  +K+
Sbjct: 534 RSR-SRSRSPYRIRNPF---------------RGSPKCFRSVSPERMSRRSVRSSDRKKA 577

Query: 118 VRP-------GASYKRQNEGNPERDKERPVQSLKTSRDTSPS--------SGSAVSSSKV 162
           +         G  + +Q           P Q  KTS  T PS        S S +    +
Sbjct: 578 LEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSI 637

Query: 163 LDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEE 215
             K   L +  L+E   K  ++K   S +  L +      GS   L T+ PE+
Sbjct: 638 RCKSKNLEDDTLSEC--KQVSDK-AVSLQRKLRKEQSLHYGSVL-LITELPED 686


>gi|21626468 zinc finger protein 638 [Homo sapiens]
          Length = 1978

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 63/233 (27%), Positives = 86/233 (36%), Gaps = 40/233 (17%)

Query: 3   SEGRYEYERIPRERA----PPRSHPSDESG-YRWTRDDHSASRQPEYRDMRDGFRRKSFY 57
           +EG  +    PR R+    P RS  S  S  +R +R       +P  R  R   R  S Y
Sbjct: 474 NEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRY 533

Query: 58  SSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKS 117
            S  +R RSPY+  N F                GS    RS SPER    S   S  +K+
Sbjct: 534 RSR-SRSRSPYRIRNPF---------------RGSPKCFRSVSPERMSRRSVRSSDRKKA 577

Query: 118 VRP-------GASYKRQNEGNPERDKERPVQSLKTSRDTSPS--------SGSAVSSSKV 162
           +         G  + +Q           P Q  KTS  T PS        S S +    +
Sbjct: 578 LEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSI 637

Query: 163 LDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEE 215
             K   L +  L+E   K  ++K   S +  L +      GS   L T+ PE+
Sbjct: 638 RCKSKNLEDDTLSEC--KQVSDK-AVSLQRKLRKEQSLHYGSVL-LITELPED 686


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 10/101 (9%)

Query: 62  ARERSPYKRDNTFFRESPVGRKD-SPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRP 120
           +R R  Y R  +  R     R      SRSGSS SS S S  RS+S S  +S+ R   + 
Sbjct: 179 SRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQS 238

Query: 121 GASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSK 161
            +  K++   +P ++K         SR  S S+G + S SK
Sbjct: 239 RSRSKKEKSRSPSKEK---------SRSRSHSAGKSRSKSK 270



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 38/144 (26%), Positives = 56/144 (38%), Gaps = 7/144 (4%)

Query: 13  PRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSS-HYARERSPYKRD 71
           P+ R+P R     +S  R      S  R+ E        R +S   S   +R RS  K  
Sbjct: 286 PKSRSPSRHKSKSKSRSR------SQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGG 339

Query: 72  NTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGN 131
           +     S    KD    R  S   SRS S  RSKS    +   ++  + G+S K++ E  
Sbjct: 340 SRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDT 399

Query: 132 PERDKERPVQSLKTSRDTSPSSGS 155
                  P +S+   R+ + S  S
Sbjct: 400 DRSQSRSPSRSVSKEREHAKSESS 423



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 59/216 (27%), Positives = 82/216 (37%), Gaps = 47/216 (21%)

Query: 12  IPRERAPPR--SHPSDESGY---RWTRDDHSASRQPEYR-------------DMRDGFRR 53
           +   R P R  S+ S  SGY   R  RD +    + EYR             D++D  R+
Sbjct: 67  VEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQ 126

Query: 54  K---SFYSSHYARER---------SPYKRDNTFFRESPV-GRK-----DSPHSRSGSSVS 95
               ++  +H  R+          S  KR       + V GRK     D P SR      
Sbjct: 127 AGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRR----- 181

Query: 96  SRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGS 155
            RSYS  RS S S  +S+H +  R      R         K R  +S   SR  S S   
Sbjct: 182 RRSYSRSRSHSRSRSRSRHSRKSR-----SRSGSSKSSHSKSRS-RSRSGSRSRSKSRSR 235

Query: 156 AVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDE 191
           + S S+   + SR   KE + + S  A +   KS +
Sbjct: 236 SQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 74/311 (23%), Positives = 110/311 (35%), Gaps = 31/311 (9%)

Query: 14  RERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK-RDN 72
           R  +  RSH    S  R +R   S S              KS +S   +R RS  + R  
Sbjct: 183 RSYSRSRSHSRSRSRSRHSRKSRSRSGSS-----------KSSHSKSRSRSRSGSRSRSK 231

Query: 73  TFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNP 132
           +  R     R     SRS S   SRS S    KS S  + Q        A  K QN  N 
Sbjct: 232 SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQ--------AEEKIQNNDNV 283

Query: 133 ERDKER-PVQSLKTSRDTSPSSGSAVSSSKVLD-KPSRLTEKELAEAASKWAAEKLEKSD 190
            + K R P +    S+  S S    V   K       R  EK L ++ S+  ++   +S 
Sbjct: 284 GKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSR 343

Query: 191 ESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVY 250
             +  +  +   G      + +     S +    E          SKA +SK K+ E   
Sbjct: 344 SRSRSKSKDKRKGRKR---SREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTD 400

Query: 251 RQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTP 310
           R    +    V    E++ +  +S Q   R+   E E+AG   +     R+        P
Sbjct: 401 RSQSRSPSRSVSK--EREHAKSESSQ---REGRGESENAGTNQETRSRSRSNSKSKPNLP 455

Query: 311 ENEGEETAQSA 321
            +E    ++SA
Sbjct: 456 -SESRSRSKSA 465



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 37/121 (30%), Positives = 48/121 (39%), Gaps = 9/121 (7%)

Query: 3   SEGRYEYERIPRERAPPRSHPSDESGYRWTRD-DHSASRQPEYRDMRDGFRRKSFYSSHY 61
           S  R + ER  R+R   R   +  S  +   D D S SR P     ++    KS  S   
Sbjct: 368 SRSRSKSER-SRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQRE 426

Query: 62  ARERSPYKRDNTFFRE-SPVGRKDSPH------SRSGSSVSSRSYSPERSKSYSFHQSQH 114
            R  S     N   R  S    K  P+      SRS S+  +RS S  RS+S S   S+ 
Sbjct: 427 GRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRS 486

Query: 115 R 115
           R
Sbjct: 487 R 487


>gi|52426743 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 10/171 (5%)

Query: 10  ERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK 69
           ER  RE+   R     E   R   ++    R  + R+ R   R +S +SS  +  R    
Sbjct: 253 EREEREKEREREREERERKRRREEEEREKERARD-RERRKRSRSRSRHSSRTSDRRCSRS 311

Query: 70  RDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE 129
           RD+   R      ++   SRS     SRS+     K  S  + + R   R   SYK +++
Sbjct: 312 RDHKRSRS-----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSK 366

Query: 130 GNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
               RD+E+  +S +  +  S    S+V S    +K S  T  E  E+ +K
Sbjct: 367 ---SRDREQDRKSKEKEKRGSDDKKSSVKSGS-REKQSEDTNTESKESDTK 413



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 35/168 (20%), Positives = 64/168 (38%), Gaps = 5/168 (2%)

Query: 35  DHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSV 94
           D    ++ + R+ R+  R +        R R   +R+    R+    ++    SR  S  
Sbjct: 244 DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRT 303

Query: 95  SSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSG 154
           S R  S  RS+ +   +S+ R+  R     + ++    ER      +  + S+     S 
Sbjct: 304 SDRRCS--RSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSY 361

Query: 155 SAVSSSKVLDKPSRLTEKELAEAASKWAAEK---LEKSDESNLPEISE 199
              S S+  ++  +  EKE   +  K ++ K    EK  E    E  E
Sbjct: 362 KHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKE 409


>gi|19923485 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 10/171 (5%)

Query: 10  ERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK 69
           ER  RE+   R     E   R   ++    R  + R+ R   R +S +SS  +  R    
Sbjct: 253 EREEREKEREREREERERKRRREEEEREKERARD-RERRKRSRSRSRHSSRTSDRRCSRS 311

Query: 70  RDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE 129
           RD+   R      ++   SRS     SRS+     K  S  + + R   R   SYK +++
Sbjct: 312 RDHKRSRS-----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSK 366

Query: 130 GNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
               RD+E+  +S +  +  S    S+V S    +K S  T  E  E+ +K
Sbjct: 367 ---SRDREQDRKSKEKEKRGSDDKKSSVKSGS-REKQSEDTNTESKESDTK 413



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 35/168 (20%), Positives = 64/168 (38%), Gaps = 5/168 (2%)

Query: 35  DHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSV 94
           D    ++ + R+ R+  R +        R R   +R+    R+    ++    SR  S  
Sbjct: 244 DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRT 303

Query: 95  SSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSG 154
           S R  S  RS+ +   +S+ R+  R     + ++    ER      +  + S+     S 
Sbjct: 304 SDRRCS--RSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSY 361

Query: 155 SAVSSSKVLDKPSRLTEKELAEAASKWAAEK---LEKSDESNLPEISE 199
              S S+  ++  +  EKE   +  K ++ K    EK  E    E  E
Sbjct: 362 KHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKE 409


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
           [Homo sapiens]
          Length = 1481

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 67/244 (27%), Positives = 96/244 (39%), Gaps = 25/244 (10%)

Query: 13  PRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYS----SHYARERS-- 66
           P  + P     S  S   ++R   S S  P  R     + R   YS    S Y R RS  
Sbjct: 277 PPYKEPSAYQSSTRSPSPYSRRQRSVS--PYSRRRSSSYERSGSYSGRSPSPYGRRRSSS 334

Query: 67  PYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKR 126
           P+    +  R SP+  + S  SRS S   SR  S    K  S  +S+H  S+ P      
Sbjct: 335 PFLSKRSLSR-SPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRH-SSISPVRLPLN 392

Query: 127 QNEGN--PERDKERPVQSLKTSRDTSPSSGSAV-----SSSKVLDKPSRLTEKELAEAAS 179
            + G     + KER   +     D   S GS V      +S V  K S L  K+L  +  
Sbjct: 393 SSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSV- 451

Query: 180 KWAAEKLEKS-DESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKA 238
                KLEKS  ++ L  ++           T + +  E++  H ++  + +Q T  SK 
Sbjct: 452 -----KLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK-AQGTRDSKP 505

Query: 239 IASK 242
           IA K
Sbjct: 506 IALK 509


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 67/244 (27%), Positives = 96/244 (39%), Gaps = 25/244 (10%)

Query: 13  PRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYS----SHYARERS-- 66
           P  + P     S  S   ++R   S S  P  R     + R   YS    S Y R RS  
Sbjct: 277 PPYKEPSAYQSSTRSPSPYSRRQRSVS--PYSRRRSSSYERSGSYSGRSPSPYGRRRSSS 334

Query: 67  PYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKR 126
           P+    +  R SP+  + S  SRS S   SR  S    K  S  +S+H  S+ P      
Sbjct: 335 PFLSKRSLSR-SPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRH-SSISPVRLPLN 392

Query: 127 QNEGN--PERDKERPVQSLKTSRDTSPSSGSAV-----SSSKVLDKPSRLTEKELAEAAS 179
            + G     + KER   +     D   S GS V      +S V  K S L  K+L  +  
Sbjct: 393 SSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSV- 451

Query: 180 KWAAEKLEKS-DESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKA 238
                KLEKS  ++ L  ++           T + +  E++  H ++  + +Q T  SK 
Sbjct: 452 -----KLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK-AQGTRDSKP 505

Query: 239 IASK 242
           IA K
Sbjct: 506 IALK 509


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
          Length = 2365

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 48/183 (26%), Positives = 74/183 (40%), Gaps = 25/183 (13%)

Query: 13   PRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFY--SSHYARERSPYKR 70
            PR  +PPR  PSD            A   P       G  R S     + +  ER  Y  
Sbjct: 1224 PRASSPPRHPPSD-----------LAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEY-- 1270

Query: 71   DNTFFRESPVGRK---DSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQ 127
              T   + P  R+     P  ++  S   R++SP R++       + RKS   GA ++ Q
Sbjct: 1271 --TVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGA-FQAQ 1327

Query: 128  NEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLE 187
            +EG  ++  +   Q L+  R +SP+    V+      K + LT +  AE    W+ EK  
Sbjct: 1328 DEGRSQQPSQGQSQLLR--RQSSPAPSRQVTMLPA--KQAELTRRSQAEPPHPWSPEKRP 1383

Query: 188  KSD 190
            + D
Sbjct: 1384 EGD 1386



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 84/398 (21%), Positives = 137/398 (34%), Gaps = 64/398 (16%)

Query: 13  PRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPY---- 68
           PR     R +P   S  R TRD+ + S        RD  R     S + A   +P     
Sbjct: 575 PRTSCAQRDNPRASSPNRATRDNPTTSCA-----QRDNPRASRTSSPNRATRDNPRTSCA 629

Query: 69  KRDNTFFRESPVGR---KDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYK 125
           +RDN   R S   R   +DSP +        R+ SP R+      Q   R S        
Sbjct: 630 QRDNP--RASSPNRTTQQDSPRTSCARRDDPRASSPNRT----IQQENPRTSCAL----- 678

Query: 126 RQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEK 185
                   RD  R     +T +  +P +  A         P+R T++E      + +  +
Sbjct: 679 --------RDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQE----NPRTSCAR 726

Query: 186 LEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKE 245
            +    S+     + +   T+    D P     N T    + +++  T+ ++    +T  
Sbjct: 727 RDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRT----IQQENLRTSCTRQDNPRTSS 782

Query: 246 IEQVYRQDCETFGMVVKMLIEKDP---SLEKSIQFALRQNLHEIESAGQTWQQVPPVRNT 302
             +  R +  T       L    P   + + + +  ++QN   I  +  T Q  P    T
Sbjct: 783 PNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQN---IPRSSSTQQDNPKTSCT 839

Query: 303 EMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAPQPL 362
           + D+      + + T     F FQ D       G   +Q    KE  L+   P ++ Q  
Sbjct: 840 KRDNLRPTCTQRDRTQS---FSFQRDNP-----GTSSSQCCTQKE-NLRPSSPHRSTQWN 890

Query: 363 QPRKKRVRRTTQLRRTTGAPDITWGM--LKKTTQEAER 398
            PR     RT +        DI W    L+ T  +  R
Sbjct: 891 NPRNSSPHRTNK--------DIPWASFPLRPTQSDGPR 920


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 50/181 (27%), Positives = 70/181 (38%), Gaps = 40/181 (22%)

Query: 11  RIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKR 70
           R+ R R+P  +          T+  HS SR P++R  R   R        + R RSP +R
Sbjct: 480 RMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQR--------WGRSRSPQRR 531

Query: 71  DNTFFRESP---------------VGRKDSPHSRS----GSSVS--------SRSYSPER 103
             +   + P                 R+   HSRS    G S S        SRS +P R
Sbjct: 532 GRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPAR 591

Query: 104 SKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKER---PVQSLKTSRDTSPSSGSAVSSS 160
            +S S   ++ R   R  A   R     P R + R   PV+  + SR  SP+  S  S S
Sbjct: 592 RRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVR--RRSRSRSPARRSGRSRS 649

Query: 161 K 161
           +
Sbjct: 650 R 650



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 60/232 (25%), Positives = 88/232 (37%), Gaps = 31/232 (13%)

Query: 3   SEGRYEYERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMR--DGFRRKS----- 55
           S  R    R  R R P R      +  R  R   S SR P  R  R     RR+S     
Sbjct: 584 SRSRTPARRRSRSRTPTRRRSRSRTPARRGR---SRSRTPARRRSRTRSPVRRRSRSRSP 640

Query: 56  FYSSHYARERSPYKRDNTFFRESPV----GRKDSPHSRSGSSVS--------SRSYSPER 103
              S  +R R+P +R  +  R +P      R  +P  RSG S S        SRS +P R
Sbjct: 641 ARRSGRSRSRTPARRGRSRSR-TPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRR 699

Query: 104 SKSYS--------FHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGS 155
            +S S         H    ++  R G+S +R+N+    + + R   S +  +    S  S
Sbjct: 700 GRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRS 759

Query: 156 AVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAP 207
              SS      SRL+ +     +S    +K +     +    S+ +A S  P
Sbjct: 760 RSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTP 811



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 16/178 (8%)

Query: 65  RSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASY 124
           RSP  +     ++   GR+    S S S    R  S ++ K  S  +S+ RK   P    
Sbjct: 181 RSPTPKQKKKKKKKDRGRR----SESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKS 236

Query: 125 KRQNEGNPERDKERPV----QSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASK 180
           KR+++ + +R + R      +S +  R TS  S S+  +S+   + S   +      A +
Sbjct: 237 KRKSK-DKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSR-SAAAKTHTTALAGR 294

Query: 181 WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKA 238
             +    +  E + P     E G+T+   T +P  PE+ T      +ED     + K+
Sbjct: 295 SPSPASGRRGEGDAP---FSEPGTTS---TQRPSSPETATKQPSSPYEDKDKDKKEKS 346



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 42/147 (28%), Positives = 55/147 (37%), Gaps = 12/147 (8%)

Query: 11   RIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMR-DGFRRKSFYSSHYARERSPYK 69
            R P  R   RS P      R +R   SAS  PE R       RR    SS    E+S   
Sbjct: 1683 RTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSS 1742

Query: 70   RDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE 129
            R     R S    +    SR G S S +    +RS+S S      R+  R   + +R   
Sbjct: 1743 RR----RRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRS-----RREKTR--TTRRRDRS 1791

Query: 130  GNPERDKERPVQSLKTSRDTSPSSGSA 156
            G+ +    R  +S   SR T    G +
Sbjct: 1792 GSSQSTSRRRQRSRSRSRVTRRRRGGS 1818



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 85/405 (20%), Positives = 140/405 (34%), Gaps = 56/405 (13%)

Query: 14   RERAPPRSHPSDESGYRWTRDDHSAS-RQPEYRDMRDGFRRKSFYSSHYARERSPY--KR 70
            RER+   S P  + G   T    S S   P  RD      R S   S    +  P    R
Sbjct: 1416 RERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSR 1475

Query: 71   DNTFFRESP----VGRKDSPHSRSGSS--VSSRSYSPERSKSYSFHQ------------- 111
              +    SP    + +   P SRS SS  ++++  +P+R +S S                
Sbjct: 1476 GRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQ 1535

Query: 112  -----SQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKP 166
                 S     V+P AS + ++E +   D +   ++    R  S        SS  +D  
Sbjct: 1536 RSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS-------GSSPEVDSK 1588

Query: 167  SRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIEL 226
            SRL+ +     +S    +K   +  +     S  E  + AP    +     S++      
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS 1648

Query: 227  FEDSQLTTRSKAIASKTKEIEQVYRQDCE--TFGMVVKMLIEKDPSLEKSIQFALRQNLH 284
             E S  T  S     K++   +  R   E  T             S E + +  L +   
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708

Query: 285  EIESAGQTWQQVPPVRNTEMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPE 344
               S+ +T  + PP       H  +P     E A+ +    +  +++           P 
Sbjct: 1709 SASSSPETRSRTPP------RHRRSPSVSSPEPAEKSRSSRRRRSASS----------PR 1752

Query: 345  MKETTLQAPQPPQAPQPLQPRKKRVR----RTTQLRRTTGAPDIT 385
             K T+ +   P   P+ LQ  + R R    RTT+ R  +G+   T
Sbjct: 1753 TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQST 1797



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 58/297 (19%), Positives = 101/297 (34%), Gaps = 24/297 (8%)

Query: 77  ESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDK 136
           + P      P+S    S SSRS +P++ K     + + R      +S +R+ + + ++ K
Sbjct: 161 KQPAPEPPKPYSLVRESSSSRSPTPKQKKK---KKKKDRGRRSESSSPRRERKKSSKKKK 217

Query: 137 ERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLT--EKELAEAASKWAAEKLEKSDESNL 194
            R     K  +  SP+  S   S     K SR T    +   A    +A+    SD S  
Sbjct: 218 HRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRS 277

Query: 195 PEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDC 254
              S      T  L    P         G   F +   T+  +  + +T   +     + 
Sbjct: 278 RSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYED 337

Query: 255 ETFGMVVKMLIEKDPSLEKS-------IQFALRQNLH-----EIESAGQTWQQVPPVRNT 302
           +      K      PS E+S           L    H      + +   + + V P    
Sbjct: 338 KDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEA 397

Query: 303 EMDHDGTPENEGEETAQSALFGFQHDASNHTIVGLGPNQVPEMKETTLQAPQPPQAP 359
               D +P    E+  QS+       +S  +     P +V     ++ ++P+P  AP
Sbjct: 398 SPTRDRSPPKSPEKLPQSS-------SSESSPPSPQPTKVSRHASSSPESPKPAPAP 447



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 56/227 (24%), Positives = 83/227 (36%), Gaps = 31/227 (13%)

Query: 22   HPSDESGYRWTRDDHSASR--QPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESP 79
            H SD S     R  HS S   Q + +    G R +S         RSP ++D   F  SP
Sbjct: 1067 HRSDTSSPE-VRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASP 1125

Query: 80   VGRKDSPHSRSGSSVSSRSYSPERSKS------YSFHQSQHRKSVRP----GASYKRQNE 129
            + +      +S     S SY    S S          +S+ + ++ P     AS  RQ +
Sbjct: 1126 MLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKD 1185

Query: 130  G-NPERDKERPVQSL--KTSRDTSPSSGSAVSSSKVLDK-----PSRLTEKELAEAASK- 180
              +P   ++RP  SL  K +  T P   S   SS    +     P+   ++EL E   K 
Sbjct: 1186 KFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKS 1245

Query: 181  ---------WAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPES 218
                       + +L++   SN     E E      L  DQ +   S
Sbjct: 1246 EEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQAS 1292



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 36/132 (27%), Positives = 52/132 (39%), Gaps = 17/132 (12%)

Query: 82   RKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKS----VRPGASYKRQ---------- 127
            R+ S  S S SS SS S S   S S S   S   +     V+P  + KR           
Sbjct: 2530 RRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEA 2589

Query: 128  -NEGNPERDK--ERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAE 184
              EG P      +R  +S  +S  +S SS S+ SSS      S  +    + ++S  ++ 
Sbjct: 2590 VREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649

Query: 185  KLEKSDESNLPE 196
               K     LP+
Sbjct: 2650 SPAKPGPQALPK 2661



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)

Query: 126  RQNEGNPE-RDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAE 184
            R +  +PE R       SL++   TSP  G + SSS V +  SR     + +   +++A 
Sbjct: 1068 RSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASR---SPIRQDRGEFSAS 1124

Query: 185  KLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTK 244
             + KS  S  PE S +++ S++    D       +     E  E   L  +  A AS  +
Sbjct: 1125 PMLKSGMS--PEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPR 1182

Query: 245  E 245
            +
Sbjct: 1183 Q 1183



 Score = 29.3 bits (64), Expect = 7.3
 Identities = 42/174 (24%), Positives = 59/174 (33%), Gaps = 18/174 (10%)

Query: 11  RIPRERAPPRSH-PSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYK 69
           R P  R   RS  P+  SG   +R      R       R   R +S      +  R+P +
Sbjct: 661 RTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQR 720

Query: 70  RDNTFFRESPVGRKDSPHSRSGSSVS------------SRSYSPERSKSYSFHQSQHRKS 117
           R  +        +  +   RS S+ S            SRS S  RSK+ S  +   R+S
Sbjct: 721 RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKS--RLSLRRS 778

Query: 118 VRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDK---PSR 168
           +   +   +Q    P R         K    T P    + SS     K   PSR
Sbjct: 779 LSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSR 832



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 48/231 (20%), Positives = 79/231 (34%), Gaps = 28/231 (12%)

Query: 14   RERAPPR-------SHPSDESGYRWTRDDHSASRQPEYRDMRDGFR--------RKSFYS 58
            R R PPR       S P      R +R   SAS        R G          ++S   
Sbjct: 1717 RSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSR 1776

Query: 59   SHYARERSPYKRDNTFFRESPVGRKDSPHSRS--------GSSVSSRSYSPERSKSYSFH 110
            S   + R+  +RD +   +S   R+    SRS        GS   SRS + + S   S  
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR 1836

Query: 111  QSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLT 170
            + + R    P +  + ++  +P   K    ++   +   S S    +S  +     SR  
Sbjct: 1837 RRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRR-----SRSR 1891

Query: 171  EKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTT 221
               ++   S+       +   S    +S   + S  P  T +     + TT
Sbjct: 1892 TSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTT 1942


>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 57/214 (26%), Positives = 80/214 (37%), Gaps = 36/214 (16%)

Query: 4   EGRYEYERIP-----RERAPPRS----HPSDESGYRWTRD-DHSASRQPEYRDMRDGFRR 53
           EGRYE  R+      RERA   S    H     G+  TR  D    R P  R ++ G   
Sbjct: 126 EGRYE-RRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGL-- 182

Query: 54  KSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHS--------RSGSSVSSRSYSPERSK 105
             +Y+S   R RSP + D    R  P  R+             R   +   R   PER+ 
Sbjct: 183 --YYAS---RSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNY 237

Query: 106 SYSFHQSQHRKSVRPGASYK---------RQNEGNPERDKERPVQSLKTSRDTSPSSGSA 156
            +S  +S H    R  +  +         R   G+  R +     S+ +S  TS  S  +
Sbjct: 238 QHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDS 297

Query: 157 VSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSD 190
            SSS   D P+R  +     A +      LEK +
Sbjct: 298 SSSSSD-DSPARSVQSAAVPAPTSQLLSSLEKDE 330


>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
          Length = 1648

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 2/116 (1%)

Query: 86   PHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKT 145
            P SRS S+ SSRS    + K  S    + R   R  +  +     +P   +ERP +  + 
Sbjct: 988  PPSRSRSTSSSRSRKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRR--QR 1045

Query: 146  SRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYE 201
            S+  S  S S  SSS+   K  +  +K        W   +      S  P  S YE
Sbjct: 1046 SKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSSSYE 1101



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 15/120 (12%)

Query: 46   DMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSP---- 101
            ++R   R +S  SS  +R+++  KR +     +  G +     RS     SRS SP    
Sbjct: 985  ELRPPSRSRSTSSSR-SRKKAKRKRVSREHGRTRSGTRSESRDRS-----SRSASPSVGE 1038

Query: 102  -----ERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSA 156
                 +RSK+ S   S  R S R  A  K+  + + E  +     S +TSR  S S GS+
Sbjct: 1039 ERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSS 1098


>gi|189011568 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 77/374 (20%), Positives = 128/374 (34%), Gaps = 55/374 (14%)

Query: 21   SHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPV 80
            +H S ++G  W +   + S   EY D R   R     S   +  R P  R  T+ RE   
Sbjct: 2495 THSSVQAG-GWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSK 2553

Query: 81   GRKDSPH----SRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE----GNP 132
                 P      R+GSS S  S S E S+       +H  S+  G    ++N+    G  
Sbjct: 2554 HSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSI-SGTKQSKENQVSAKGTW 2612

Query: 133  ERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSD-E 191
             + KE       ++  T  S  +  + SK L         ++A A SK     +   D  
Sbjct: 2613 RKIKENEFSPTNSTSQTVSSGATNGAESKTL-------IYQMAPAVSKTEDVWVRIEDCP 2665

Query: 192  SNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYR 251
             N P       G+T P+     E+   N        +DS+     + + +          
Sbjct: 2666 INNPRSGRSPTGNTPPVIDSVSEKANPN-------IKDSKDNQAKQNVGN---------- 2708

Query: 252  QDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPE 311
                  G V    +  +  L   IQ         +++  Q   ++ P +N  +    T E
Sbjct: 2709 ------GSVPMRTVGLENRLNSFIQ---------VDAPDQKGTEIKPGQNNPVPVSETNE 2753

Query: 312  NE-GEETAQSALFGFQHDASNHTIVG----LGPNQVPEMKETTLQAPQPPQAPQPLQPRK 366
            +   E T  S+    +H + + T+         N  P        + +P Q P P+    
Sbjct: 2754 SSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNT 2813

Query: 367  KRVRRTTQLRRTTG 380
            K+    T    ++G
Sbjct: 2814 KKRDSKTDSTESSG 2827


>gi|189011566 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 77/374 (20%), Positives = 128/374 (34%), Gaps = 55/374 (14%)

Query: 21   SHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPV 80
            +H S ++G  W +   + S   EY D R   R     S   +  R P  R  T+ RE   
Sbjct: 2495 THSSVQAG-GWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSK 2553

Query: 81   GRKDSPH----SRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE----GNP 132
                 P      R+GSS S  S S E S+       +H  S+  G    ++N+    G  
Sbjct: 2554 HSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSI-SGTKQSKENQVSAKGTW 2612

Query: 133  ERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSD-E 191
             + KE       ++  T  S  +  + SK L         ++A A SK     +   D  
Sbjct: 2613 RKIKENEFSPTNSTSQTVSSGATNGAESKTL-------IYQMAPAVSKTEDVWVRIEDCP 2665

Query: 192  SNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYR 251
             N P       G+T P+     E+   N        +DS+     + + +          
Sbjct: 2666 INNPRSGRSPTGNTPPVIDSVSEKANPN-------IKDSKDNQAKQNVGN---------- 2708

Query: 252  QDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPE 311
                  G V    +  +  L   IQ         +++  Q   ++ P +N  +    T E
Sbjct: 2709 ------GSVPMRTVGLENRLNSFIQ---------VDAPDQKGTEIKPGQNNPVPVSETNE 2753

Query: 312  NE-GEETAQSALFGFQHDASNHTIVG----LGPNQVPEMKETTLQAPQPPQAPQPLQPRK 366
            +   E T  S+    +H + + T+         N  P        + +P Q P P+    
Sbjct: 2754 SSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNT 2813

Query: 367  KRVRRTTQLRRTTG 380
            K+    T    ++G
Sbjct: 2814 KKRDSKTDSTESSG 2827


>gi|53759122 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 77/374 (20%), Positives = 128/374 (34%), Gaps = 55/374 (14%)

Query: 21   SHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPV 80
            +H S ++G  W +   + S   EY D R   R     S   +  R P  R  T+ RE   
Sbjct: 2495 THSSVQAG-GWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSK 2553

Query: 81   GRKDSPH----SRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNE----GNP 132
                 P      R+GSS S  S S E S+       +H  S+  G    ++N+    G  
Sbjct: 2554 HSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSI-SGTKQSKENQVSAKGTW 2612

Query: 133  ERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSD-E 191
             + KE       ++  T  S  +  + SK L         ++A A SK     +   D  
Sbjct: 2613 RKIKENEFSPTNSTSQTVSSGATNGAESKTL-------IYQMAPAVSKTEDVWVRIEDCP 2665

Query: 192  SNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYR 251
             N P       G+T P+     E+   N        +DS+     + + +          
Sbjct: 2666 INNPRSGRSPTGNTPPVIDSVSEKANPN-------IKDSKDNQAKQNVGN---------- 2708

Query: 252  QDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPE 311
                  G V    +  +  L   IQ         +++  Q   ++ P +N  +    T E
Sbjct: 2709 ------GSVPMRTVGLENRLNSFIQ---------VDAPDQKGTEIKPGQNNPVPVSETNE 2753

Query: 312  NE-GEETAQSALFGFQHDASNHTIVG----LGPNQVPEMKETTLQAPQPPQAPQPLQPRK 366
            +   E T  S+    +H + + T+         N  P        + +P Q P P+    
Sbjct: 2754 SSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNT 2813

Query: 367  KRVRRTTQLRRTTG 380
            K+    T    ++G
Sbjct: 2814 KKRDSKTDSTESSG 2827


>gi|197313748 SET domain containing 2 [Homo sapiens]
          Length = 2564

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 55/233 (23%), Positives = 86/233 (36%), Gaps = 16/233 (6%)

Query: 11  RIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDM------RDGFRRKSFYSSHYARE 64
           R  RER   RSH   E G R T   +S S +  Y D          +R ++ YS  Y   
Sbjct: 395 RSERERRRSRSHSRSERGSR-TNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDN 453

Query: 65  RSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSP-----ERSKSYSFHQSQHRKSVR 119
           R+    D+    +    R+ S HS S   + + SYS      +   SY   + + + S +
Sbjct: 454 RARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSK 513

Query: 120 PGASYKRQNEGNPERDKERPVQSLKTSRDTSPS--SGSAVSSSKVLDKPSRLTEKELAEA 177
                KR +E    +    P   L   R +S S    SA      L KP   ++K     
Sbjct: 514 LERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSF 573

Query: 178 ASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDS 230
                 E++++S   +L   +    GS   +    PE  ++ +        DS
Sbjct: 574 CCTELNEEIKQSHSFSLQ--TPCSKGSELRMINKNPEREKAGSPAPSNRLNDS 624


>gi|24762236 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing A [Homo sapiens]
          Length = 312

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 38/115 (33%), Positives = 50/115 (43%), Gaps = 12/115 (10%)

Query: 25  DESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKD 84
           DE   R    DH   R+  YRD+ D  RR        +R RSP +R  +  R SP  R++
Sbjct: 201 DEKLERVPSPDH---RRRSYRDL-DKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRE 256

Query: 85  SPHSRSGSSVSSRSYS---PERSKSYSFHQSQHRKS-----VRPGASYKRQNEGN 131
              S+S     SRS       RSKS   H+S   +S      R   S+K+   GN
Sbjct: 257 RHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGN 311


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 42/131 (32%), Positives = 52/131 (39%), Gaps = 23/131 (17%)

Query: 14   RERAPPRSHPSDESGYRW-TRD---DHSASRQPEYRDMRDGFRRKSF--------YSSHY 61
            + R+P RS    E+  R  TR     HS SR    R     +R +S+        YS   
Sbjct: 1310 QSRSPSRSRSKSETKSRHRTRSVSYSHSRSRS---RSSTSSYRSRSYSRSRSRGWYSRGR 1366

Query: 62   ARERSP----YKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKS 117
             R RS     YK   T  R         PHSRS S      YS  RS+S    +SQ   S
Sbjct: 1367 TRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRS----RSQRSDS 1422

Query: 118  VRPGASYKRQN 128
               G SY R++
Sbjct: 1423 YHRGRSYNRRS 1433



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 51/240 (21%), Positives = 102/240 (42%), Gaps = 29/240 (12%)

Query: 37  SASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRD----NTFFRESPVGRKDSPHSRSGS 92
           S++R+ +    R+   R S  SSH++ +R   K D    ++    S    +   HS+S S
Sbjct: 470 SSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYS 529

Query: 93  SVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPER-----DKERPVQSLKTSR 147
             SSRS +  +S S+S  +S+ R S + G  ++++   +P +      + +PV++ +  R
Sbjct: 530 RGSSRSRTASKSSSHSRSRSKSRSSSKSG--HRKRASKSPRKTASQLSENKPVKT-EPLR 586

Query: 148 DTSPSSGSAVSSSKVLDK-----------PSRLTEKELAEAASKWAAEKLEKSDESNLPE 196
            T   + + V    V +            PSR    +     S    ++++      LP 
Sbjct: 587 ATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPI 646

Query: 197 ISEY------EAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVY 250
            S Y      E GS++     +       +T+       S+ + RS++ +S+++   + Y
Sbjct: 647 QSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSY 706



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 47/214 (21%), Positives = 82/214 (38%), Gaps = 8/214 (3%)

Query: 9   YERIPRERAPPRSHPSDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPY 68
           YERI   +A        +S Y       + S    ++  ++    +S YS +  R     
Sbjct: 630 YERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESS 689

Query: 69  KRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQN 128
            R  +    S    +    SRS +S  SRS SP  S+S+S ++          +SY   +
Sbjct: 690 PRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPS-SRSHSRNKYSDHSQCSRSSSYTSIS 748

Query: 129 EGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEK 188
             +  R K R    L++S   +  S    SSS      S+  +     +  +  +E    
Sbjct: 749 SDDGRRAKRR----LRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSS 804

Query: 189 SDESNLPEISEYEAGSTAPLFTDQPEEPESNTTH 222
            D S+  E S  +A  +A    ++ ++ +   TH
Sbjct: 805 LDYSSDSEQSSVQATQSA---QEKEKQGQMERTH 835



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 11/98 (11%)

Query: 24   SDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYS--SHYARERSPYK--RDNTFFRESP 79
            S  S YR  +   ++SR        D   R   Y+  S+Y+R RS  +  R +++ R   
Sbjct: 1369 SRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHR--- 1425

Query: 80   VGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKS 117
             GR  +  SRS  S  S S   E  +SYS H+S    S
Sbjct: 1426 -GRSYNRRSRSCRSYGSDS---ESDRSYSHHRSPSESS 1459


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,554,862
Number of Sequences: 37866
Number of extensions: 913588
Number of successful extensions: 5401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 4508
Number of HSP's gapped (non-prelim): 948
length of query: 434
length of database: 18,247,518
effective HSP length: 105
effective length of query: 329
effective length of database: 14,271,588
effective search space: 4695352452
effective search space used: 4695352452
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.