Search of human proteins with 21396489

Search of human proteins with 21396489

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21396489 mitochondrial lon peptidase 1 [Homo sapiens]
         (959 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21396489 mitochondrial lon peptidase 1 [Homo sapiens]             1898   0.0  
gi|31377667 peroxisomal LON protease-like [Homo sapiens]              462   e-130
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...    49   2e-05
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]            49   3e-05
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]    48   4e-05
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]               47   7e-05
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...    47   9e-05
gi|41352705 kinesin family member 3C [Homo sapiens]                    47   1e-04
gi|6005942 valosin-containing protein [Homo sapiens]                   46   2e-04
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    45   4e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       44   7e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       44   7e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        44   7e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        44   7e-04
gi|55956899 keratin 9 [Homo sapiens]                                   44   0.001
gi|38044112 restin isoform b [Homo sapiens]                            44   0.001
gi|4506751 restin isoform a [Homo sapiens]                             44   0.001
gi|40806170 spastin isoform 2 [Homo sapiens]                           43   0.001
gi|11875211 spastin isoform 1 [Homo sapiens]                           43   0.001
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]             43   0.001
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]             42   0.002
gi|154091020 leucine-rich repeats and calponin homology (CH) dom...    42   0.002
gi|13540606 caseinolytic peptidase B [Homo sapiens]                    42   0.002
gi|157671927 spermatogenesis associated 5 [Homo sapiens]               42   0.002
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]        42   0.003
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]          42   0.003
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                       42   0.003
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                        42   0.003
gi|11321607 thyroid hormone receptor interactor 13 [Homo sapiens]      42   0.003
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]            42   0.004

>gi|21396489 mitochondrial lon peptidase 1 [Homo sapiens]
          Length = 959

 Score = 1898 bits (4917), Expect = 0.0
 Identities = 959/959 (100%), Positives = 959/959 (100%)

Query: 1   MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPA 60
           MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPA
Sbjct: 1   MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPA 60

Query: 61  IGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDV 120
           IGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDV
Sbjct: 61  IGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDV 120

Query: 121 FPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE 180
           FPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE
Sbjct: 121 FPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE 180

Query: 181 SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSK 240
           SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSK
Sbjct: 181 SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSK 240

Query: 241 RGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTI 300
           RGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTI
Sbjct: 241 RGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTI 300

Query: 301 RDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY 360
           RDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY
Sbjct: 301 RDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY 360

Query: 361 KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEK 420
           KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEK
Sbjct: 361 KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEK 420

Query: 421 FRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDL 480
           FRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDL
Sbjct: 421 FRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDL 480

Query: 481 ARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARAL 540
           ARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARAL
Sbjct: 481 ARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARAL 540

Query: 541 NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQ 600
           NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQ
Sbjct: 541 NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQ 600

Query: 601 GDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSG 660
           GDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSG
Sbjct: 601 GDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSG 660

Query: 661 YVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVL 720
           YVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVL
Sbjct: 661 YVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVL 720

Query: 721 RKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFV 780
           RKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFV
Sbjct: 721 RKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFV 780

Query: 781 ETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHI 840
           ETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHI
Sbjct: 781 ETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHI 840

Query: 841 HLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTI 900
           HLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTI
Sbjct: 841 HLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTI 900

Query: 901 AAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER 959
           AAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
Sbjct: 901 AAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER 959


>gi|31377667 peroxisomal LON protease-like [Homo sapiens]
          Length = 852

 Score =  462 bits (1188), Expect = e-130
 Identities = 256/665 (38%), Positives = 388/665 (58%), Gaps = 60/665 (9%)

Query: 331 LSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQT 390
           L D+  ++    + E   +L+  ++ +R    + LL ++ E  KL Q+  +  ++  K  
Sbjct: 183 LPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDK-- 240

Query: 391 HRKYLLQEQLKIIKKELGLEKDDKDAIEEKF---RERLKELVVPKHVMDVVDEELSKLGL 447
            R   ++   +I      LE +D+D   +      ++++   +P+    V  +E+ +L  
Sbjct: 241 -RVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKK 299

Query: 448 LDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAV 507
           +     E+ +TRNYL+ +  +PW K + + LD+  A+ +L+ DHY ME +KKR+LE++AV
Sbjct: 300 MPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAV 359

Query: 508 SQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVG 567
            QL+ + +G ILCF GPPGVGKTS+ RS+A+ L RE+ R ++GG+ D ++I+GHRRTYVG
Sbjct: 360 RQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVG 419

Query: 568 AMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVP 627
           +MPG+II  LK     NP+ L+DEVDK+G+  QGDP++ALLE+LDPEQN NF DHYL+V 
Sbjct: 420 SMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVA 479

Query: 628 VDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDES 687
            DLS+VLFI TAN T TIP  L DRME+I V GY  +EK+ IA R+L+P+     GL   
Sbjct: 480 FDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQ 539

Query: 688 KAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEV---------- 737
           + ++       +I +Y RE+GVR+L +++  + R  A K+  G+ +  ++          
Sbjct: 540 QIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREG 599

Query: 738 ---------TPEN---------------------LQDFVGKPVFTVERMYDVTPPGVVMG 767
                     PE+                     L+D +G P++ +E    ++ PGV +G
Sbjct: 600 CREHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIG 659

Query: 768 LAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQ 827
           LAWT +GG  +FVE S         + D +G L +TGQLG+VMKESA +A ++ R+   +
Sbjct: 660 LAWTPLGGEIMFVEAS---------RMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKK 710

Query: 828 HAPAN-----DYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGE 882
           +   N     D L  + IHLH P GA  KDGPSAG TIVT L SL  GR VR ++AMTGE
Sbjct: 711 YQLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGE 770

Query: 883 VSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREI 942
           ++L G +LPVGGIK+K +AA RAG+  +++P  N+KD   +   + + L         E+
Sbjct: 771 ITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEV 830

Query: 943 FDIAF 947
            + AF
Sbjct: 831 LNAAF 835


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 100/436 (22%), Positives = 169/436 (38%), Gaps = 89/436 (20%)

Query: 344 HELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKII 403
           HE QD      IP     ALS+ + +  LS L    G E E+      R   LQ++L+ +
Sbjct: 5   HEAQD-----EIP-----ALSVSRPQTGLSFL----GPEPEDLEDLYSRYKKLQQELEFL 50

Query: 404 KKELGLEKDDKDAIEEKF---RERLKEL----VVPKHVMDVVDEELSKLGLLDNHSSEFN 456
           + +    KD++  ++++F   +E +K +    +V    ++ VD+  + +G     +    
Sbjct: 51  EVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVR 110

Query: 457 VT----RNYLDWLTSIPWGKYSNENLDLARAQA--------------VLEEDHYGMEDVK 498
           +     R  L    S+   K+SN  +D+   +A              V+  D  GM+  K
Sbjct: 111 ILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQK 170

Query: 499 KRILEFIAVSQLRGSTQGKI-------LCFYGPPGVGKTSIARSIARALNREYFRFSVGG 551
           + + E + +         +I       +  YGPPG GKT +A+++A      + R  V G
Sbjct: 171 QEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIR--VVG 228

Query: 552 MTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP-LILIDEVDKIG-------RGYQGDP 603
              V       + Y+G  P  +    +  K   P +I IDE+D I         G   + 
Sbjct: 229 SEFV-------QKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREV 281

Query: 604 SSALLELLDP----EQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVS 659
              LLELL+     +QN N          D      +    +   I  PL DR +   + 
Sbjct: 282 QRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIF 341

Query: 660 GYVAQEKLAIAERY----LVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQ 715
             +   K+ ++E       V +   + G D              I   C+ESG+  +++ 
Sbjct: 342 STIT-SKMNLSEEVDLEDYVARPDKISGAD--------------INSICQESGMLAVREN 386

Query: 716 VEKVLRK---SAYKIV 728
              VL K    AYK V
Sbjct: 387 RYIVLAKDFEKAYKTV 402


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 93/396 (23%), Positives = 169/396 (42%), Gaps = 52/396 (13%)

Query: 381 REVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR---ERLKELVVPKHVMDV 437
           +E++ ++K+      L+EQLK + K+    ++D  A++   +   E LK+L   K ++  
Sbjct: 34  KEIDGRLKE------LREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKA 87

Query: 438 VDEELSKLGL---LDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEE----- 489
            +     +G    LD    +   TR  LD +T++   +Y    +D        E+     
Sbjct: 88  TNGPRYVVGCRRQLDKSKLKPG-TRVALD-MTTLTIMRYLPREVDPLVYNMSHEDPGNVS 145

Query: 490 --DHYGMEDVKKRILEFIAVS-------QLRGSTQGKILCFYGPPGVGKTSIARSIARAL 540
             +  G+ +  + + E I +        Q  G    K    YGPPG GKT +AR++A  L
Sbjct: 146 YSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQL 205

Query: 541 NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP-LILIDEVDKIGRGY 599
           +  + +     + D          Y+G     I +     +   P +I +DE+D IG   
Sbjct: 206 DCNFLKVVSSSIVD---------KYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRR 256

Query: 600 QGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTI-PEPLR----DRME 654
             + +SA  E+   ++    L + +D    L +V  I   N  DT+ P  LR    DR  
Sbjct: 257 FSEGTSADREI---QRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKI 313

Query: 655 MINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQK 714
            I++     Q +L I + +  P  +      E+  KLS       ++  C E+G+  ++ 
Sbjct: 314 HIDLPN--EQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRA 371

Query: 715 QVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPV 750
             + V+++   K V   A+S ++  E+  D+  KPV
Sbjct: 372 DHDFVVQEDFMKAVRKVADSKKL--ESKLDY--KPV 403


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 89/401 (22%), Positives = 155/401 (38%), Gaps = 75/401 (18%)

Query: 379 LGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKF---RERLKEL----VVP 431
           LG E E+      R   LQ++L+ ++ +    KD++  ++++F   +E +K +    +V 
Sbjct: 30  LGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVI 89

Query: 432 KHVMDVVDEELSKLGLLDNHSSEFNVT----RNYLDWLTSIPWGKYSNENLDLARAQA-- 485
              ++ VD+  + +G     +    +     R  L    S+   K+SN  +D+   +A  
Sbjct: 90  GQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADS 149

Query: 486 ------------VLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKI-------LCFYGPPG 526
                       V+  D  GM+  K+ + E + +         +I       +  YGPPG
Sbjct: 150 SIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPG 209

Query: 527 VGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP- 585
            GKT +A+++A      + R  V G   V       + Y+G  P  +    +  K   P 
Sbjct: 210 CGKTMLAKAVAHHTTAAFIR--VVGSEFV-------QKYLGEGPRMVRDVFRLAKENAPA 260

Query: 586 LILIDEVDKIG-------RGYQGDPSSALLELLDP----EQNANFLDHYLDVPVDLSKVL 634
           +I IDE+D I         G   +    LLELL+     +QN N          D     
Sbjct: 261 IIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPA 320

Query: 635 FICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERY----LVPQARALCGLDESKAK 690
            +    +   I  PL DR +   +   +   K+ ++E       V +   + G D     
Sbjct: 321 LLRPGRLDRKIEFPLPDRRQKRLIFSTIT-SKMNLSEEVDLEDYVARPDKISGAD----- 374

Query: 691 LSSDVLTLLIKQYCRESGVRNLQKQVEKVLRK---SAYKIV 728
                    I   C+ESG+  +++    VL K    AYK V
Sbjct: 375 ---------INSICQESGMLAVRENRYIVLAKDFEKAYKTV 406


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 87/383 (22%), Positives = 152/383 (39%), Gaps = 47/383 (12%)

Query: 478 LDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLR------GSTQGKILCFYGPPGVGKTS 531
           +D    + V  +D  GM + K  + EF+   +        G+   K     GPPG GKT 
Sbjct: 298 VDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTL 357

Query: 532 IARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP-LILID 590
           +A+++A      +   ++ G   V  I G     +GA   ++    K+ +   P ++ ID
Sbjct: 358 LAKAVATEAQVPF--LAMAGPEFVEVIGG-----LGA--ARVRSLFKEARARAPCIVYID 408

Query: 591 EVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLR 650
           E+D +G+  +   + +     + EQ  N L   +D       V+ + + N  D +   L 
Sbjct: 409 EIDAVGK--KRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALM 466

Query: 651 -----DRMEMINVSGYVAQEKLAIAERYL--VPQARALCGLDESKAKLSSDVLTLLIKQY 703
                DR   I++     QE+  I E++L  +   ++     +  A+L+       I   
Sbjct: 467 RPGRLDRHVFIDLP--TLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANI 524

Query: 704 CRESGVR------------NLQKQVEKVLRKSA--YKIVSGEAESVEVTPENLQDFVGKP 749
           C E+ +             N +  VE+VL  +A   KI+S E + V    E+    VG  
Sbjct: 525 CNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWM 584

Query: 750 VFTVERM--YDVTP-PGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSL---EVT 803
           +   E +    +TP     +G A        LF +  L         G    +L   EVT
Sbjct: 585 LEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVT 644

Query: 804 GQLGEVMKESARIAYTFARAFLM 826
               + +++  RIAY+  + F M
Sbjct: 645 SGAQDDLRKVTRIAYSMVKQFGM 667


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 82/370 (22%), Positives = 140/370 (37%), Gaps = 72/370 (19%)

Query: 407 LGLEKDDKDAIEEKFRERLKEL----VVPKHVMDVVDEELSKLGLLDNHSSEFNVT---- 458
           LG E +D + +  +++E +K +    +V    ++ VD+  + +G     +    +     
Sbjct: 30  LGPEPEDLEDLYSRYKEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID 89

Query: 459 RNYLDWLTSIPWGKYSNENLDLARAQA--------------VLEEDHYGMEDVKKRILEF 504
           R  L    S+   K+SN  +D+   +A              V+  D  GM+  K+ + E 
Sbjct: 90  RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA 149

Query: 505 IAVSQLRGSTQGKI-------LCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAE 557
           + +         +I       +  YGPPG GKT +A+++A      + R  V G   V  
Sbjct: 150 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIR--VVGSEFV-- 205

Query: 558 IKGHRRTYVGAMPGKIIQCLKKTKTENP-LILIDEVDKIG-------RGYQGDPSSALLE 609
                + Y+G  P  +    +  K   P +I IDE+D I         G   +    LLE
Sbjct: 206 -----QKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLE 260

Query: 610 LLDP----EQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQE 665
           LL+     +QN N          D      +    +   I  PL DR +   +   +   
Sbjct: 261 LLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTIT-S 319

Query: 666 KLAIAERY----LVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLR 721
           K+ ++E       V +   + G D              I   C+ESG+  +++    VL 
Sbjct: 320 KMNLSEEVDLEDYVARPDKISGAD--------------INSICQESGMLAVRENRYIVLA 365

Query: 722 K---SAYKIV 728
           K    AYK V
Sbjct: 366 KDFEKAYKTV 375


>gi|41352705 kinesin family member 3C [Homo sapiens]
          Length = 793

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 85/411 (20%), Positives = 170/411 (41%), Gaps = 50/411 (12%)

Query: 70  EASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAI 129
           E  ++ G   +GG      G   G GG+GG AG GE P   +   +++  +   +  +A 
Sbjct: 251 ERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAG-GERPKEASKINLSLSALGNVIAALAG 309

Query: 130 TRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTG 189
            R+   P        ++ KL  LL+  +      + V      S+  D  ESL  +    
Sbjct: 310 NRSTHIP-------YRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYD--ESLSTLRFAN 360

Query: 190 TFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK----- 244
               I     + +  +  ++   +  I+R L+ + E+     K +PRRKS R KK     
Sbjct: 361 RAKNIKNKPRVNEDPKDTLLREFQEEIAR-LKAQLEKRGMLGK-RPRRKSSRRKKAVSAP 418

Query: 245 --------------EAEDELSARH-PAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEV 289
                         E ED+ +  H P +  +E   E   E  + E +  + E+    ++ 
Sbjct: 419 PGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDD 478

Query: 290 KALTAEIVKTIRD--IIALNPLYRE-SVLQMMQAGQRVVDNPIYLSDMGAALTGAESHEL 346
           ++L +E  + + +     L  L RE    +++ A  + +++ + +          E  ++
Sbjct: 479 RSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKM 538

Query: 347 -----QDVLEETNIPKRLYKALSLLKKE-FELSKLQQRLGREVEEKIKQTHRKYLLQEQL 400
                Q++ E+    + + + + L  +E  EL      L +EVE K K+  + Y    +L
Sbjct: 539 LELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLY---AKL 595

Query: 401 KIIKKELGLEKDD----KDAIEEKFRERLKELVVPKHVMD--VVDEELSKL 445
           + +K E+  + D+    +  +EE   E+ +EL +   +++  +  EE +K+
Sbjct: 596 QAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKI 646


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 21/124 (16%)

Query: 489 EDHYGMEDVKKRILEFIAVSQLR-------GSTQGKILCFYGPPGVGKTSIARSIARALN 541
           ED  G+EDVK+ + E +             G T  K + FYGPPG GKT +A++IA    
Sbjct: 477 EDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQ 536

Query: 542 REYFRFSVGGMTDVAEIKGHR--RTYVGAMPGKIIQCLKKTKTENPLIL-IDEVDKIGRG 598
             +             IKG      + G     + +   K +   P +L  DE+D I + 
Sbjct: 537 ANFI-----------SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKA 585

Query: 599 YQGD 602
             G+
Sbjct: 586 RGGN 589



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 10/78 (12%)

Query: 519 LCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLK 578
           +  YGPPG GKT IAR++A       F F + G   ++++ G   +        + +  +
Sbjct: 241 ILLYGPPGTGKTLIARAVANETGA--FFFLINGPEIMSKLAGESES-------NLRKAFE 291

Query: 579 KTKTENP-LILIDEVDKI 595
           + +   P +I IDE+D I
Sbjct: 292 EAEKNAPAIIFIDELDAI 309


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 66/318 (20%), Positives = 144/318 (45%), Gaps = 50/318 (15%)

Query: 142  IEVKN-KKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDL 200
            +E+K  K+ + LL R     +  V    + D+   S + ++ DE+   G  ++  E+Q  
Sbjct: 926  VEIKTLKEQLNLLSRAEEAKKEQV----EEDNEVSSGLKQNYDEMSPAGQISK-EELQHE 980

Query: 201  GDKLR----------MIVMGHRRVHISRQLEVEPEEPEAENKHK---PRRKSKRGKKEAE 247
             D L+             + +R+  + R   +E E    +++ K   P  +++RG+ E E
Sbjct: 981  FDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE-E 1039

Query: 248  DELSARHPAELAMEPTPELPA---------EVLMVEVENVVHEDFQVTEEVKALTAEIVK 298
            D+ +  +  +       E+           EV +  +   + E     E+ +AL  ++ +
Sbjct: 1040 DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ 1099

Query: 299  TIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKR 358
            T++D        + + + ++QA   + +N   +  +  + T A   +   +++ET +   
Sbjct: 1100 TLQD--------KTNQIDLLQA--EISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149

Query: 359  LYKALS------LLKKEFELSKLQQRLGREVEEKIKQTHRKYLL---QEQLKIIKKELGL 409
                 S      L +K   L K +++L ++++E +  T RK +L   QE+ + +++EL  
Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQLQKKLQEAL--TSRKAILKKAQEKERHLREELKQ 1207

Query: 410  EKDDKDAIEEKFRERLKE 427
            +KDD + ++E+F E+ KE
Sbjct: 1208 QKDDYNRLQEQFDEQSKE 1225



 Score = 35.0 bits (79), Expect = 0.34
 Identities = 59/307 (19%), Positives = 126/307 (41%), Gaps = 69/307 (22%)

Query: 137  RFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHE 196
            R + II  K++ + E      +L +   G+    DD N  +     + I +     Q+  
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545

Query: 197  MQDLGDKLRMIVMGHRRVHISRQLEVEPEE-PEAENKHKPRRKSKRGKKEAEDELSARHP 255
            ++D   K              + LEV+ ++  E ENK+    +  +  +EA ++L     
Sbjct: 2546 IKDSQQK--------------QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF- 2590

Query: 256  AELAMEPTPELPAEVLMVEVENVVHEDFQ-VTEEVKALTAEIVKTIRDIIALNPLYRESV 314
                                 N + E+ Q +++E+++L   I +  R + AL     E  
Sbjct: 2591 ---------------------NALQEEKQDLSKEIESLKVSISQLTRQVTALQ---EEGT 2626

Query: 315  LQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSK 374
            L +  A  +V +  ++     +AL  +    + ++ EE          L  ++KE     
Sbjct: 2627 LGLYHAQLKVKEEEVHRL---SALFSSSQKRIAELEEE----------LVCVQKE----- 2668

Query: 375  LQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHV 434
              +++G E+E+K+K+         +LK +  + G+ +++ +  EE+  E  ++LV  +  
Sbjct: 2669 AAKKVG-EIEDKLKK---------ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718

Query: 435  MDVVDEE 441
            + +V +E
Sbjct: 2719 LLMVTKE 2725



 Score = 31.2 bits (69), Expect = 4.9
 Identities = 79/358 (22%), Positives = 133/358 (37%), Gaps = 76/358 (21%)

Query: 147  KKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRM 206
            +K  EL +    L Q Y  V      SNE++ ++ + E       A   E Q+L  KLR 
Sbjct: 1606 EKHKELQKEYEILLQSYENV------SNEAERIQHVVE-------AVRQEKQELYGKLRS 1652

Query: 207  IVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGK----KEAEDELSAR-HPA----- 256
                 +      Q E E E  E + K +   KSK+ K    +E  D L A  HPA     
Sbjct: 1653 TEANKKETEKQLQ-EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAK 1711

Query: 257  ---ELAMEPTPELPAEVLMVEVE---------NVVHEDFQVTEEVKALTAEIVKTIRDII 304
               E  +     +  E+  V++E         +++ E   ++EEV+ L  +I   +    
Sbjct: 1712 ECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQA 1771

Query: 305  ALNPLYR-ESVLQMMQAGQRVVDNPIYLSD---MGAALTGAES----------------- 343
             L    + ++   + + G + +       D   M    T +ES                 
Sbjct: 1772 NLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831

Query: 344  -HELQDVLEETNIPKRLYKALSLLK---KEF-------------ELSKLQQRLGREVEEK 386
              E+ + L++ +  K     L   K   KEF             ++S     L    EE 
Sbjct: 1832 HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891

Query: 387  IKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKEL--VVPKHVMDVVDEEL 442
             K       +QE+L  + K     +++KD +EE+   +L EL   +  +  DV D ++
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 85/347 (24%), Positives = 148/347 (42%), Gaps = 43/347 (12%)

Query: 96  GAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRR 155
           G  GSA AGE       TP   P   P +P   +T     P           K  E LR 
Sbjct: 34  GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPL-----PSPSKEEEGLRA 88

Query: 156 KVR-LAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRV 214
           +VR L +    + LKR  + +   ++ L++  H     Q+ ++Q+   K++         
Sbjct: 89  QVRDLEEKLETLRLKR--AEDKAKLKELEK--HK---IQLEQVQEWKSKMQ--------- 132

Query: 215 HISRQLEVEPEEPEAENKHKPRRKSK-RGKKEAEDELSARHPAELAMEPTPELPAEVLMV 273
              +Q +++    EA  + K   ++K R  +E  D   A   A L  E   E  AE L  
Sbjct: 133 --EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE-RAESLQQ 189

Query: 274 EVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSD 333
           EVE +     ++T +++ L AEI +   D  A +      + Q+ +   R+ D  + + D
Sbjct: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASS----YQLKQLEEQNARLKDALVRMRD 245

Query: 334 MGAALTGAESHELQDVLEETNIP--------KRLYKALSLLKKEFELSKLQQRLGREVEE 385
           + ++    E  +LQ ++E+ N          +RL + LS  +   +  K Q       EE
Sbjct: 246 LSSS-EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304

Query: 386 KIKQ-THRKYLLQEQLKIIKKELG-LE--KDDKDAIEEKFRERLKEL 428
            ++  T R   L+E+++ +++ +G LE   +  D ++E  RE   EL
Sbjct: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 85/347 (24%), Positives = 148/347 (42%), Gaps = 43/347 (12%)

Query: 96  GAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRR 155
           G  GSA AGE       TP   P   P +P   +T     P           K  E LR 
Sbjct: 148 GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPL-----PSPSKEEEGLRA 202

Query: 156 KVR-LAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRV 214
           +VR L +    + LKR  + +   ++ L++  H     Q+ ++Q+   K++         
Sbjct: 203 QVRDLEEKLETLRLKR--AEDKAKLKELEK--HK---IQLEQVQEWKSKMQ--------- 246

Query: 215 HISRQLEVEPEEPEAENKHKPRRKSK-RGKKEAEDELSARHPAELAMEPTPELPAEVLMV 273
              +Q +++    EA  + K   ++K R  +E  D   A   A L  E   E  AE L  
Sbjct: 247 --EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE-RAESLQQ 303

Query: 274 EVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSD 333
           EVE +     ++T +++ L AEI +   D  A +      + Q+ +   R+ D  + + D
Sbjct: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASS----YQLKQLEEQNARLKDALVRMRD 359

Query: 334 MGAALTGAESHELQDVLEETNIP--------KRLYKALSLLKKEFELSKLQQRLGREVEE 385
           + ++    E  +LQ ++E+ N          +RL + LS  +   +  K Q       EE
Sbjct: 360 LSSS-EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418

Query: 386 KIKQ-THRKYLLQEQLKIIKKELG-LE--KDDKDAIEEKFRERLKEL 428
            ++  T R   L+E+++ +++ +G LE   +  D ++E  RE   EL
Sbjct: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 465


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 85/347 (24%), Positives = 148/347 (42%), Gaps = 43/347 (12%)

Query: 96  GAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRR 155
           G  GSA AGE       TP   P   P +P   +T     P           K  E LR 
Sbjct: 34  GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPL-----PSPSKEEEGLRA 88

Query: 156 KVR-LAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRV 214
           +VR L +    + LKR  + +   ++ L++  H     Q+ ++Q+   K++         
Sbjct: 89  QVRDLEEKLETLRLKR--AEDKAKLKELEK--HK---IQLEQVQEWKSKMQ--------- 132

Query: 215 HISRQLEVEPEEPEAENKHKPRRKSK-RGKKEAEDELSARHPAELAMEPTPELPAEVLMV 273
              +Q +++    EA  + K   ++K R  +E  D   A   A L  E   E  AE L  
Sbjct: 133 --EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE-RAESLQQ 189

Query: 274 EVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSD 333
           EVE +     ++T +++ L AEI +   D  A +      + Q+ +   R+ D  + + D
Sbjct: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASS----YQLKQLEEQNARLKDALVRMRD 245

Query: 334 MGAALTGAESHELQDVLEETNIP--------KRLYKALSLLKKEFELSKLQQRLGREVEE 385
           + ++    E  +LQ ++E+ N          +RL + LS  +   +  K Q       EE
Sbjct: 246 LSSS-EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304

Query: 386 KIKQ-THRKYLLQEQLKIIKKELG-LE--KDDKDAIEEKFRERLKEL 428
            ++  T R   L+E+++ +++ +G LE   +  D ++E  RE   EL
Sbjct: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 85/347 (24%), Positives = 148/347 (42%), Gaps = 43/347 (12%)

Query: 96  GAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRR 155
           G  GSA AGE       TP   P   P +P   +T     P           K  E LR 
Sbjct: 168 GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPL-----PSPSKEEEGLRA 222

Query: 156 KVR-LAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRV 214
           +VR L +    + LKR  + +   ++ L++  H     Q+ ++Q+   K++         
Sbjct: 223 QVRDLEEKLETLRLKR--AEDKAKLKELEK--HK---IQLEQVQEWKSKMQ--------- 266

Query: 215 HISRQLEVEPEEPEAENKHKPRRKSK-RGKKEAEDELSARHPAELAMEPTPELPAEVLMV 273
              +Q +++    EA  + K   ++K R  +E  D   A   A L  E   E  AE L  
Sbjct: 267 --EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE-RAESLQQ 323

Query: 274 EVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSD 333
           EVE +     ++T +++ L AEI +   D  A +      + Q+ +   R+ D  + + D
Sbjct: 324 EVEALKERVDELTTDLEILKAEIEEKGSDGAASS----YQLKQLEEQNARLKDALVRMRD 379

Query: 334 MGAALTGAESHELQDVLEETNIP--------KRLYKALSLLKKEFELSKLQQRLGREVEE 385
           + ++    E  +LQ ++E+ N          +RL + LS  +   +  K Q       EE
Sbjct: 380 LSSS-EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438

Query: 386 KIKQ-THRKYLLQEQLKIIKKELG-LE--KDDKDAIEEKFRERLKEL 428
            ++  T R   L+E+++ +++ +G LE   +  D ++E  RE   EL
Sbjct: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 485


>gi|55956899 keratin 9 [Homo sapiens]
          Length = 623

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 28/74 (37%), Positives = 34/74 (45%), Gaps = 11/74 (14%)

Query: 58  GPAIGGQWRGFWEASSRG-------GGAFSGGEDASEGGAEE----GAGGAGGSAGAGEG 106
           G   GG  RGF  AS  G       GG F GG     GG       G GG GG AG G+G
Sbjct: 87  GGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGGDG 146

Query: 107 PVITALTPMTIPDV 120
            ++TA    T+ ++
Sbjct: 147 GILTANEKSTMQEL 160



 Score = 37.7 bits (86), Expect = 0.052
 Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 3/55 (5%)

Query: 55  WGRGP--AIGGQWRGFWEASSRGGGAFS-GGEDASEGGAEEGAGGAGGSAGAGEG 106
           +GRG     GG + G       GGG+ S GG   S GG     GG+GG  G G G
Sbjct: 485 YGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSG 539



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 21/58 (36%), Positives = 25/58 (43%), Gaps = 6/58 (10%)

Query: 55  WGRGPAIGGQWRGFWEASSRGG------GAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           +G G   GG   G +   S GG      G  SGG   + GG     GG+GG  G G G
Sbjct: 520 YGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSG 577



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 24/56 (42%), Positives = 26/56 (46%), Gaps = 8/56 (14%)

Query: 54  LWGRGPAIGGQWRGFWEASSRGGGAFS---GGEDASEGGAEEGAGGAGGSAGAGEG 106
           L GRG + G   RG     SRGG   S   GG     GG     GG+GGS G G G
Sbjct: 475 LGGRGGSGGSYGRG-----SRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSG 525



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 18/45 (40%), Positives = 20/45 (44%)

Query: 62  GGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           GG         S GGG+  GGE     G  E A G+GG  G G G
Sbjct: 574 GGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSG 618



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 18/51 (35%), Positives = 20/51 (39%)

Query: 56  GRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           G     GG   G    +  GG    GG     GG     GG+GGS G G G
Sbjct: 541 GHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSG 591



 Score = 33.9 bits (76), Expect = 0.75
 Identities = 17/50 (34%), Positives = 20/50 (40%)

Query: 55  WGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAG 104
           +G G    G   G +   S  GG   GG     GG   G  G G S G+G
Sbjct: 506 YGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSG 555



 Score = 33.5 bits (75), Expect = 0.98
 Identities = 21/52 (40%), Positives = 25/52 (48%), Gaps = 4/52 (7%)

Query: 58  GPAIGGQWRGFWEASSRGGGAFSGGE---DASEGGAEEGAGGAGGSAGAGEG 106
           G + GG   G + ASS GG  F GG      + GG    +GG GG  G G G
Sbjct: 70  GYSYGGGSGGGFSASSLGG-GFGGGSRGFGGASGGGYSSSGGFGGGFGGGSG 120



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 5/56 (8%)

Query: 56  GRGPAIGGQWRGFWEASSRGGGAFSG-----GEDASEGGAEEGAGGAGGSAGAGEG 106
           G G + G   RG    S  GGG+  G     G     GG+  G  G+GG +G G G
Sbjct: 480 GSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYG 535



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 19/49 (38%), Positives = 21/49 (42%)

Query: 58  GPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           G + GG   G     S G G   GG   S GG+  G GG  GS G   G
Sbjct: 536 GGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGG 584



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 17/45 (37%), Positives = 19/45 (42%)

Query: 62  GGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           GG         S GGG+ SGG      G   G G +GGS G   G
Sbjct: 508 GGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSG 552



 Score = 31.2 bits (69), Expect = 4.9
 Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 5/54 (9%)

Query: 55  WGRGPAIGGQWRGFWEASSRGG--GAFSGGEDASEGGAEEGAGGAGGSAGAGEG 106
           +G G + GG   G   + SRGG  G++ GG  +  G      GG+GG    G G
Sbjct: 497 YGGGGSGGGYGGG---SGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSG 547



 Score = 31.2 bits (69), Expect = 4.9
 Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 5/50 (10%)

Query: 62  GGQWRGFWEASSRGGGAFSGGEDASEGGAEEG-----AGGAGGSAGAGEG 106
           GG    +   S  GGG+  G    S GG   G     +GG+GG+ G G G
Sbjct: 514 GGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSG 563



 Score = 31.2 bits (69), Expect = 4.9
 Identities = 16/53 (30%), Positives = 22/53 (41%), Gaps = 2/53 (3%)

Query: 56  GRGPAIGGQWRGFWEASSRGGGAFSGGEDA--SEGGAEEGAGGAGGSAGAGEG 106
           G     GG + G   +    GG + GG  +    GG+  G  G GG +G   G
Sbjct: 549 GHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYG 601



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 1/45 (2%)

Query: 62  GGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGG-AGGSAGAGE 105
           GG   G       GGG+ S G      G   G GG +GGS G GE
Sbjct: 560 GGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGE 604


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 58/308 (18%), Positives = 135/308 (43%), Gaps = 38/308 (12%)

Query: 173 SNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEP-EAEN 231
           ++    +E L   +  G   +  E  +L  ++  + + ++    + Q + + E    A+ 
Sbjct: 586 ASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645

Query: 232 KHKPRRKSKRGKKEAEDELSA----------RHPAELAMEPTPELPAEVLMVEVENVVHE 281
               R K  +  KE E+ L A          +H  E+         AE+ + E+E +  +
Sbjct: 646 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK 705

Query: 282 DFQVTEEVKALTAEIVKTIRDIIALNPLYRES---------VLQMMQAGQRVVDNPIYLS 332
             + T+ +   T+++  T   ++ L+ L + S         + Q ++A ++ + +     
Sbjct: 706 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 765

Query: 333 DMGAALTGAESHELQ-----------DVLEETNIPKRLYKALSLLKKEF-ELSKLQQRLG 380
           +  ++   + + ELQ           ++ E + + + L K L +LK++F E S+    + 
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825

Query: 381 REVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR---ERLKELVVPKHVMDV 437
           R ++E + + H+K   +EQ  ++  +L   +++   +E KFR   ER ++L+  K  ++ 
Sbjct: 826 RSMQETVNKLHQK---EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882

Query: 438 VDEELSKL 445
              E+ K+
Sbjct: 883 DIAEIMKM 890


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 58/308 (18%), Positives = 135/308 (43%), Gaps = 38/308 (12%)

Query: 173 SNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEP-EAEN 231
           ++    +E L   +  G   +  E  +L  ++  + + ++    + Q + + E    A+ 
Sbjct: 621 ASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 680

Query: 232 KHKPRRKSKRGKKEAEDELSA----------RHPAELAMEPTPELPAEVLMVEVENVVHE 281
               R K  +  KE E+ L A          +H  E+         AE+ + E+E +  +
Sbjct: 681 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK 740

Query: 282 DFQVTEEVKALTAEIVKTIRDIIALNPLYRES---------VLQMMQAGQRVVDNPIYLS 332
             + T+ +   T+++  T   ++ L+ L + S         + Q ++A ++ + +     
Sbjct: 741 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 800

Query: 333 DMGAALTGAESHELQ-----------DVLEETNIPKRLYKALSLLKKEF-ELSKLQQRLG 380
           +  ++   + + ELQ           ++ E + + + L K L +LK++F E S+    + 
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860

Query: 381 REVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR---ERLKELVVPKHVMDV 437
           R ++E + + H+K   +EQ  ++  +L   +++   +E KFR   ER ++L+  K  ++ 
Sbjct: 861 RSMQETVNKLHQK---EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 917

Query: 438 VDEELSKL 445
              E+ K+
Sbjct: 918 DIAEIMKM 925


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 20/129 (15%)

Query: 475 NENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGS------TQGKILCFYGPPGVG 528
           NE +D     AV  +D  G +  K+ + E + +  LR           + L  +GPPG G
Sbjct: 298 NEIVD--NGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNG 355

Query: 529 KTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTE--NPL 586
           KT +A+++A   N  +F  S   +T           YVG    K+++ L     E    +
Sbjct: 356 KTMLAKAVAAESNATFFNISAASLTS---------KYVGE-GEKLVRALFAVARELQPSI 405

Query: 587 ILIDEVDKI 595
           I IDEVD +
Sbjct: 406 IFIDEVDSL 414


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 20/129 (15%)

Query: 475 NENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGS------TQGKILCFYGPPGVG 528
           NE +D     AV  +D  G +  K+ + E + +  LR           + L  +GPPG G
Sbjct: 330 NEIVD--NGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNG 387

Query: 529 KTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTE--NPL 586
           KT +A+++A   N  +F  S   +T           YVG    K+++ L     E    +
Sbjct: 388 KTMLAKAVAAESNATFFNISAASLTS---------KYVGE-GEKLVRALFAVARELQPSI 437

Query: 587 ILIDEVDKI 595
           I IDEVD +
Sbjct: 438 IFIDEVDSL 446


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/137 (27%), Positives = 58/137 (42%), Gaps = 23/137 (16%)

Query: 489 EDHYGMEDVKKRILEFIAVS------QLRGSTQGKILCFYGPPGVGKTSIARSIARALNR 542
           +D  G E+ K  I+EF+         Q  G+   K     GPPG GKT +A++ A   N 
Sbjct: 308 KDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV 367

Query: 543 EYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLIL-IDEVDKIGR---- 597
            +   S     ++         +VG  P ++       +   P IL IDE+D +GR    
Sbjct: 368 PFITVSGSEFLEM---------FVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGR 418

Query: 598 ---GYQGDPSSALLELL 611
              G Q +  + L +LL
Sbjct: 419 GNFGGQSEQENTLNQLL 435


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 60/293 (20%), Positives = 130/293 (44%), Gaps = 33/293 (11%)

Query: 337 ALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLL 396
           AL G E  EL++    + +  R Y    + + +  ++   Q L R   ++ +   +  LL
Sbjct: 2   ALDGPEQMELEEGKAGSGL--RQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLL 59

Query: 397 QEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELS--------KLGLL 448
           +E+L++++++     +   A+++K +  +K     K V+DV D+ +         ++ L 
Sbjct: 60  REELQLLQEQGSYVGEVVRAMDKK-KVLVKVHPEGKFVVDV-DKNIDINDVTPNCRVALR 117

Query: 449 DNHSSEFNVTRNYLDWLTSIPW-GKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAV 507
           ++  +   +  N +D L S+    K  +   ++      L++    +++V +  ++   +
Sbjct: 118 NDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGG---LDKQIKEIKEVIELPVKHPEL 174

Query: 508 SQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVG 567
            +  G  Q K +  YGPPG GKT +AR++A   +  + R S   +          + ++G
Sbjct: 175 FEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELV---------QKFIG 225

Query: 568 AMPGKIIQCLKKTKTENP-LILIDEVDKI-------GRGYQGDPSSALLELLD 612
                + +     +   P +I +DE+D I       G G   +    +LELL+
Sbjct: 226 EGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLN 278


>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
           containing 2 [Homo sapiens]
          Length = 765

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 4/55 (7%)

Query: 71  ASSRGGGAFSGGEDASEGGAEEG----AGGAGGSAGAGEGPVITALTPMTIPDVF 121
           A+S+GGG  SGG     GG+  G     GG GG+ G G G   T + P+ +P +F
Sbjct: 2   AASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLF 56


>gi|13540606 caseinolytic peptidase B [Homo sapiens]
          Length = 707

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 20/152 (13%)

Query: 518 ILCFYGPPGVGKTSIARSIARALNRE----YFRFSVGGMT---DVAEIKGHRRTYVGAMP 570
           +  F G  G+GKT +A+  A+ ++++    + R  +       +VA+  G    YVG   
Sbjct: 376 VFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEE 435

Query: 571 GKIIQCLKKTK-TENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVD 629
           G   Q  KK K   N ++L DEVDK       D  + +L+L D  +    L       +D
Sbjct: 436 GG--QLTKKLKQCPNAVVLFDEVDKA----HPDVLTIMLQLFDEGR----LTDGKGKTID 485

Query: 630 LSKVLFICTANV-TDTIPE-PLRDRMEMINVS 659
               +FI T+NV +D I +  L+ R E + +S
Sbjct: 486 CKDAIFIMTSNVASDEIAQHALQLRQEALEMS 517


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 66/279 (23%), Positives = 115/279 (41%), Gaps = 65/279 (23%)

Query: 522 YGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTK 581
           YGPPG GKT IAR++A           VG    V         + G    K+ Q   +  
Sbjct: 393 YGPPGTGKTMIARAVAN---------EVGAYVSVINGPEIISKFYGETEAKLRQIFAEAT 443

Query: 582 TENP-LILIDEVDKIGRGYQGDPS-------SALLELLDPEQNANFLDHYLDVPVDLSKV 633
             +P +I IDE+D +    +G  +       ++LL L+D           +   V   +V
Sbjct: 444 LRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDG----------IGSEVSEGQV 493

Query: 634 LFICTANVTDTIPEPLR-----DRMEMINVSGYVAQEKLAIAER------YLVPQARALC 682
           L +   N    +   LR     D+   I V    AQ++L I ++      +L+ +A  L 
Sbjct: 494 LVLGATNRPHALDAALRRPGRFDKEIEIGVPN--AQDRLDILQKLLRRVPHLLTEAELLQ 551

Query: 683 GLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENL 742
             + +   + +D     +K  C E+G+  L++ ++K       K+    A  V++T   L
Sbjct: 552 LANSAHGYVGAD-----LKVLCNEAGLCALRRILKKQPNLPDVKV----AGLVKIT---L 599

Query: 743 QDFVGKPVFTVERMYDVTPPGV------VMGLAWTAMGG 775
           +DF       ++ M D+ P  +      V  ++W+ +GG
Sbjct: 600 KDF-------LQAMNDIRPSAMREIAIDVPNVSWSDIGG 631



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 14/82 (17%)

Query: 517 KILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHR--RTYVGAMPGKII 574
           K +  YGPPG  KT IA+++A          +  G+  +A IKG      YVG     + 
Sbjct: 662 KGVLLYGPPGCSKTMIAKALA----------NESGLNFLA-IKGPELMNKYVGESERAVR 710

Query: 575 QCLKKTKTENP-LILIDEVDKI 595
           +  +K +   P +I  DE+D +
Sbjct: 711 ETFRKARAVAPSIIFFDELDAL 732


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 17/115 (14%)

Query: 489 EDHYGMEDVKKRI-------LEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALN 541
           E+  G+EDVK ++       L+F       G TQ K +  YGPPG  KT++ R++A + +
Sbjct: 464 EEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCH 523

Query: 542 REYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLIL-IDEVDKI 595
             +   S   +            +VG     + Q  ++ +   P IL +DE+D I
Sbjct: 524 CSFVSVSGADLFS---------PFVGDSEKVLSQIFRQARASTPAILFLDEIDSI 569



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 9/92 (9%)

Query: 523 GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKT 582
           GPPGVGKT + R++AR    E    S         ++G R         ++ Q  ++  +
Sbjct: 241 GPPGVGKTQLVRAVAREAGAELLAVS------APALQGSRPGETEENVRRVFQRARELAS 294

Query: 583 ENP-LILIDEVDKI--GRGYQGDPSSALLELL 611
             P L+ +DE+D +   RG +   S  + ++L
Sbjct: 295 RGPSLLFLDEMDALCPQRGSRAPESRVVAQVL 326


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 35/138 (25%), Positives = 59/138 (42%), Gaps = 16/138 (11%)

Query: 519 LCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLK 578
           +  +GPPG GK+ +A+++A   N   F FS+     V++  G           K+++ L 
Sbjct: 170 ILLFGPPGTGKSYLAKAVATEANNSTF-FSISSSDLVSKWLGESE--------KLVKNLF 220

Query: 579 KTKTEN--PLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFI 636
           +   EN   +I IDE+D +      + S A   +        FL     V VD   +L +
Sbjct: 221 QLARENKPSIIFIDEIDSLCGSRSENESEAARRI-----KTEFLVQMQGVGVDNDGILVL 275

Query: 637 CTANVTDTIPEPLRDRME 654
              N+   +   +R R E
Sbjct: 276 GATNIPWVLDSAIRRRFE 293


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 34/126 (26%), Positives = 60/126 (47%), Gaps = 16/126 (12%)

Query: 478 LDLARAQAVLEEDHYGMEDVKKR---ILEFIAVSQ---LRGSTQGKILCFYGPPGVGKTS 531
           +D  + + V  E   G+E+ K+    ++EF+   Q   + G    K +   GPPG GKT 
Sbjct: 328 VDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTL 387

Query: 532 IARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP-LILID 590
           +AR++A   +  ++ ++ G   D          +VG    +I    ++ K   P +I ID
Sbjct: 388 LARAVAGEADVPFY-YASGSEFD--------EMFVGVGASRIRNLFREAKANAPCVIFID 438

Query: 591 EVDKIG 596
           E+D +G
Sbjct: 439 ELDSVG 444


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 34/126 (26%), Positives = 60/126 (47%), Gaps = 16/126 (12%)

Query: 478 LDLARAQAVLEEDHYGMEDVKKR---ILEFIAVSQ---LRGSTQGKILCFYGPPGVGKTS 531
           +D  + + V  E   G+E+ K+    ++EF+   Q   + G    K +   GPPG GKT 
Sbjct: 271 VDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTL 330

Query: 532 IARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP-LILID 590
           +AR++A   +  ++ ++ G   D          +VG    +I    ++ K   P +I ID
Sbjct: 331 LARAVAGEADVPFY-YASGSEFD--------EMFVGVGASRIRNLFREAKANAPCVIFID 381

Query: 591 EVDKIG 596
           E+D +G
Sbjct: 382 ELDSVG 387


>gi|11321607 thyroid hormone receptor interactor 13 [Homo sapiens]
          Length = 432

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 42/176 (23%), Positives = 79/176 (44%), Gaps = 20/176 (11%)

Query: 496 DVKKRILEFIAVSQLRGS--------TQGKILCFYGPPGVGKTSIARSIARALN-REYFR 546
           +VK  +L+++  + L           T  +++  +GPPG GKTS+ +++A+ L  R   R
Sbjct: 144 EVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSR 203

Query: 547 FSVGGMTDVAEIKGHRRTYVGAMPGKI-------IQCLKKTKTENPLILIDEVDKIGRGY 599
           +  G + ++       + +  +  GK+       IQ L   K     +LIDEV+ +    
Sbjct: 204 YRYGQLIEINSHSLFSKWF--SESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAA- 260

Query: 600 QGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEM 655
             +   A  E  D  +  N +   +D     S V+ + T+N+T+ I     DR ++
Sbjct: 261 -RNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADI 315


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 41/148 (27%), Positives = 63/148 (42%), Gaps = 25/148 (16%)

Query: 476 ENLDLARAQAVLE--------EDHYGMEDVKKRILEFIAV-----SQLRGSTQGKILCFY 522
           E L  A +QAV           D  G+++VKK ILE I +       L    +   L  +
Sbjct: 684 EQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLH 743

Query: 523 GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKT 582
           GPPG GKT +A+++A   +  +   SV G   +         YVG     + +   + + 
Sbjct: 744 GPPGTGKTLLAKAVATECSLTF--LSVKGPELI-------NMYVGQSEENVREVFARARA 794

Query: 583 ENP-LILIDEVDKI--GRGYQGDPSSAL 607
             P +I  DE+D +   RG  GD    +
Sbjct: 795 AAPCIIFFDELDSLAPSRGRSGDSGGVM 822


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,460,709
Number of Sequences: 37866
Number of extensions: 1762129
Number of successful extensions: 14950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 346
Number of HSP's that attempted gapping in prelim test: 11294
Number of HSP's gapped (non-prelim): 2595
length of query: 959
length of database: 18,247,518
effective HSP length: 112
effective length of query: 847
effective length of database: 14,006,526
effective search space: 11863527522
effective search space used: 11863527522
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.