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Search of human proteins with 21327667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21327667 block of proliferation 1 [Homo sapiens]
(746 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21327667 block of proliferation 1 [Homo sapiens] 1535 0.0
gi|239743654 PREDICTED: similar to block of proliferation 1 [Hom... 1330 0.0
gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 57 5e-08
gi|56243583 WD repeat domain 18 [Homo sapiens] 57 6e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 55 2e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 55 2e-07
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 55 2e-07
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 55 2e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 4e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 53 9e-07
gi|89886480 zinedin isoform 2 [Homo sapiens] 53 1e-06
gi|89886477 zinedin isoform 1 [Homo sapiens] 53 1e-06
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 52 3e-06
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 51 4e-06
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 50 6e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 50 1e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 50 1e-05
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 48 3e-05
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 48 3e-05
gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens] 47 5e-05
gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens] 47 5e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 47 8e-05
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 46 1e-04
gi|134133292 WD repeat domain 27 [Homo sapiens] 45 2e-04
gi|4758876 poly(A) binding protein, nuclear 1 [Homo sapiens] 45 2e-04
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 45 3e-04
gi|18874090 WD repeat domain 48 [Homo sapiens] 45 3e-04
gi|14150171 THO complex 3 [Homo sapiens] 45 3e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 44 5e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 44 5e-04
>gi|21327667 block of proliferation 1 [Homo sapiens]
Length = 746
Score = 1535 bits (3974), Expect = 0.0
Identities = 746/746 (100%), Positives = 746/746 (100%)
Query: 1 MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVF 60
MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVF
Sbjct: 1 MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVF 60
Query: 61 SGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGD 120
SGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGD
Sbjct: 61 SGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGD 120
Query: 121 EYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPD 180
EYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPD
Sbjct: 121 EYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPD 180
Query: 181 YWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRP 240
YWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRP
Sbjct: 181 YWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRP 240
Query: 241 ADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHV 300
ADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHV
Sbjct: 241 ADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHV 300
Query: 301 PAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFI 360
PAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFI
Sbjct: 301 PAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFI 360
Query: 361 QERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLS 420
QERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLS
Sbjct: 361 QERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLS 420
Query: 421 VSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVL 480
VSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVL
Sbjct: 421 VSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVL 480
Query: 481 LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQV 540
LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQV
Sbjct: 481 LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQV 540
Query: 541 TWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQR 600
TWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQR
Sbjct: 541 TWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQR 600
Query: 601 SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLR 660
SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLR
Sbjct: 601 SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLR 660
Query: 661 HHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLG 720
HHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLG
Sbjct: 661 HHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLG 720
Query: 721 VLDVIFHPTQPWVFSSGADGTVRLFT 746
VLDVIFHPTQPWVFSSGADGTVRLFT
Sbjct: 721 VLDVIFHPTQPWVFSSGADGTVRLFT 746
>gi|239743654 PREDICTED: similar to block of proliferation 1 [Homo
sapiens]
Length = 668
Score = 1330 bits (3441), Expect = 0.0
Identities = 644/647 (99%), Positives = 644/647 (99%)
Query: 100 EQVQASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI 159
E ASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI
Sbjct: 22 EPSPASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI 81
Query: 160 YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP 219
YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP
Sbjct: 82 YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP 141
Query: 220 YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS 279
YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS
Sbjct: 142 YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS 201
Query: 280 FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK 339
FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK
Sbjct: 202 FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK 261
Query: 340 LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ 399
LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ
Sbjct: 262 LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ 321
Query: 400 PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS 459
PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS
Sbjct: 322 PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS 381
Query: 460 VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS 519
VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS
Sbjct: 382 VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS 441
Query: 520 EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH 579
EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH
Sbjct: 442 EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH 501
Query: 580 GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 639
GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS
Sbjct: 502 GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 561
Query: 640 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 699
YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL
Sbjct: 562 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 621
Query: 700 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT 746
QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT
Sbjct: 622 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT 668
>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
Length = 780
Score = 57.4 bits (137), Expect = 5e-08
Identities = 71/295 (24%), Positives = 114/295 (38%), Gaps = 33/295 (11%)
Query: 397 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 456
D++P T +R H V C+ +S G+ SG DG ++ W P
Sbjct: 505 DVEPIYT-----FRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNID---PYDSY 556
Query: 457 VKSVAWNPSPAVCLVAAAVEDSVL-LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARW 515
SV P D+V L A RL++ S D L + E P
Sbjct: 557 DPSVLRGP-------LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPA----- 604
Query: 516 LEASEEERQVGL--RLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQS 573
L + +++G+ + + P V +G + TQ L + + S
Sbjct: 605 LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSS 664
Query: 574 PFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 632
Q+ RV HP P + A + R ++ Y +L ++ + + V+SLAV P G
Sbjct: 665 C------QINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNG 718
Query: 633 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 684
++ GS+D + ++L+ T H KK ++ VAFHP AS D
Sbjct: 719 LYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/73 (32%), Positives = 40/73 (54%), Gaps = 7/73 (9%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 466
H + V L+V P G +L+SGS D S+RLW + + C++ + VA++PS
Sbjct: 705 HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSK 764
Query: 467 AVCLVAAAVEDSV 479
C +A+A D++
Sbjct: 765 --CYIASAGADAL 775
Score = 31.6 bits (70), Expect = 2.8
Identities = 42/175 (24%), Positives = 61/175 (34%), Gaps = 44/175 (25%)
Query: 577 RSHGQ-VQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 635
RSH ++ +AFHP P L+ AS+ H L+ +K P K S
Sbjct: 460 RSHFDGIRALAFHPIEPVLITASED-----HTLKMWNLQKTAPAKKSTS----------- 503
Query: 636 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVY 695
L +P R HK + V SG DG ++
Sbjct: 504 ---------------LDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDG-------LIQ 541
Query: 696 NDLLQNPLLVPV-----KVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
NP + P VL+G +L V + + + S ADGT+RL+
Sbjct: 542 GWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLW 596
>gi|56243583 WD repeat domain 18 [Homo sapiens]
Length = 432
Score = 57.0 bits (136), Expect = 6e-08
Identities = 26/54 (48%), Positives = 38/54 (70%)
Query: 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 461
V++GH + V CLSVS G L+SGS D ++RLW+V + +C+RTV + G V + A
Sbjct: 264 VFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTNAA 317
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/294 (24%), Positives = 109/294 (37%), Gaps = 52/294 (17%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSV 460
P +A + GH D V C++ SP G L SGS D ++R+W VP V G +S
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNVKG--EST 97
Query: 461 AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPARWL 516
+ A D G V S D+ + + + L Q W+
Sbjct: 98 VFRAHTATVRSVHFCSD---------GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148
Query: 517 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 576
++ D +V A+ T V + S R +
Sbjct: 149 RCAKFS-----------------------PDGRLIVSASDDKT-VKLWDKSSRECVHSYC 184
Query: 577 RSHGQVQRVAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 635
G V V FHP+ + A +V+++ + L + + V+ L+ HP+G+ +
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 636 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 245 ITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 36.6 bits (83), Expect = 0.087
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 575 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 633
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 634 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 693
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 159 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 694 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 744
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 218 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 30.8 bits (68), Expect = 4.8
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 638 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 687
GS DS L+ + + ++ YR H K A+ V F P L ASGS D +V
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGH-KDAVTCVNFSPSGHLLASGSRDKTV 85
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/294 (24%), Positives = 109/294 (37%), Gaps = 52/294 (17%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSV 460
P +A + GH D V C++ SP G L SGS D ++R+W VP V G +S
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNVKG--EST 97
Query: 461 AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPARWL 516
+ A D G V S D+ + + + L Q W+
Sbjct: 98 VFRAHTATVRSVHFCSD---------GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148
Query: 517 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 576
++ D +V A+ T V + S R +
Sbjct: 149 RCAKFS-----------------------PDGRLIVSASDDKT-VKLWDKSSRECVHSYC 184
Query: 577 RSHGQVQRVAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 635
G V V FHP+ + A +V+++ + L + + V+ L+ HP+G+ +
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 636 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 245 ITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 36.6 bits (83), Expect = 0.087
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 575 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 633
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 634 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 693
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 159 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 694 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 744
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 218 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 30.8 bits (68), Expect = 4.8
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 638 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 687
GS DS L+ + + ++ YR H K A+ V F P L ASGS D +V
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGH-KDAVTCVNFSPSGHLLASGSRDKTV 85
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/292 (21%), Positives = 115/292 (39%), Gaps = 27/292 (9%)
Query: 397 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 456
D++P T +R H V L++S G+ SG D +++ W + P V
Sbjct: 522 DVEPIYT-----FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---------PSPSV 567
Query: 457 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWL 516
+ P+ + + L + ++L++ S D + + P E+ P
Sbjct: 568 DPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEK---LPCICT 624
Query: 517 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 576
+++ + + P VT G + L T +L Q+
Sbjct: 625 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGL------ 678
Query: 577 RSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 635
+S+ + RV HP P + A + R ++ + ++ ++ + V+SLAV P G +
Sbjct: 679 QSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYL 738
Query: 636 ICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 684
+ GS+D + ++LD T + H KK ++ VAFH AS D
Sbjct: 739 MSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 790
Score = 40.8 bits (94), Expect = 0.005
Identities = 78/348 (22%), Positives = 133/348 (38%), Gaps = 40/348 (11%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 469
R H D VR L+ P LV+ S+D +L+LW + +TVP KS + + P +
Sbjct: 477 RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ-----KTVPAK---KSASLDVEP-IY 527
Query: 470 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 529
A + + L + G++ +G D + + P P + P E + V
Sbjct: 528 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS-PSVDPYDTYEPN-----VLAGT 581
Query: 530 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR--RSHGQVQRVAF 587
+ H V + + G + L + + T L + + + + HG V F
Sbjct: 582 LVGHTDAVWGLAYSGIKNQL--LSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDF 639
Query: 588 HPARPFLLVASQR--SVRLYHL--------LRQELTKKLMPNCKWVSSLAVHPAGDNVIC 637
P +V S S +Y L L ++ L N ++ + HP I
Sbjct: 640 IGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSN-NHINRVVSHPTLPVTIT 698
Query: 638 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYND 697
D + +FD + M+ H A+ ++A P SGS D S+
Sbjct: 699 AHEDRHIKFFDNKTGKMIHSMVAH-LDAVTSLAVDPNGIYLMSGSHDCSI---------R 748
Query: 698 LLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
L V+ + H D + DV FH ++ ++ S+GAD ++F
Sbjct: 749 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 796
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 655 PYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLL--VPVKVLKG 712
P LR H +RA+AFHP P+ + S+D ++ + + ++ L P+ +
Sbjct: 472 PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 531
Query: 713 HVLTRDLGVLDVIFHPTQPWVFSSGADGTVR 743
H+ VL + FS G D T++
Sbjct: 532 HIGP----VLSLAISSNGEQCFSGGIDATIQ 558
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/292 (21%), Positives = 115/292 (39%), Gaps = 27/292 (9%)
Query: 397 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 456
D++P T +R H V L++S G+ SG D +++ W + P V
Sbjct: 438 DVEPIYT-----FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---------PSPSV 483
Query: 457 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWL 516
+ P+ + + L + ++L++ S D + + P E+ P
Sbjct: 484 DPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEK---LPCICT 540
Query: 517 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 576
+++ + + P VT G + L T +L Q+
Sbjct: 541 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGL------ 594
Query: 577 RSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 635
+S+ + RV HP P + A + R ++ + ++ ++ + V+SLAV P G +
Sbjct: 595 QSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYL 654
Query: 636 ICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 684
+ GS+D + ++LD T + H KK ++ VAFH AS D
Sbjct: 655 MSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 706
Score = 40.8 bits (94), Expect = 0.005
Identities = 78/348 (22%), Positives = 133/348 (38%), Gaps = 40/348 (11%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 469
R H D VR L+ P LV+ S+D +L+LW + +TVP KS + + P +
Sbjct: 393 RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ-----KTVPAK---KSASLDVEP-IY 443
Query: 470 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 529
A + + L + G++ +G D + + P P + P E + V
Sbjct: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS-PSVDPYDTYEPN-----VLAGT 497
Query: 530 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR--RSHGQVQRVAF 587
+ H V + + G + L + + T L + + + + HG V F
Sbjct: 498 LVGHTDAVWGLAYSGIKNQL--LSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDF 555
Query: 588 HPARPFLLVASQR--SVRLYHL--------LRQELTKKLMPNCKWVSSLAVHPAGDNVIC 637
P +V S S +Y L L ++ L N ++ + HP I
Sbjct: 556 IGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSN-NHINRVVSHPTLPVTIT 614
Query: 638 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYND 697
D + +FD + M+ H A+ ++A P SGS D S+
Sbjct: 615 AHEDRHIKFFDNKTGKMIHSMVAH-LDAVTSLAVDPNGIYLMSGSHDCSI---------R 664
Query: 698 LLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
L V+ + H D + DV FH ++ ++ S+GAD ++F
Sbjct: 665 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 655 PYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLL--VPVKVLKG 712
P LR H +RA+AFHP P+ + S+D ++ + + ++ L P+ +
Sbjct: 388 PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 447
Query: 713 HVLTRDLGVLDVIFHPTQPWVFSSGADGTVR 743
H+ VL + FS G D T++
Sbjct: 448 HIGP----VLSLAISSNGEQCFSGGIDATIQ 474
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 54.3 bits (129), Expect = 4e-07
Identities = 70/342 (20%), Positives = 133/342 (38%), Gaps = 63/342 (18%)
Query: 409 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT-ARCVRTVPVGGVVKSVAWNPSPA 467
++GH + L +SP G+ L + S D L LW AR R V VV SV ++P
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH-- 71
Query: 468 VCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGL 527
G+ L + S D+ + ++P + +
Sbjct: 72 -------------------GNLLASASRDRTVRLWIPDKRGKFSEFK------------- 99
Query: 528 RLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAF 587
H PV V + G +LA A++ + + +R S +R +H V+ F
Sbjct: 100 ----AHTAPVRSVDFSADGQFLAT--ASEDKSIKVWSMYRQRFLYSLYRHTH-WVRCAKF 152
Query: 588 HP-ARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVW 646
P R + + ++++++ ++ + + + + +P+G + D +
Sbjct: 153 SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
Query: 647 FDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPL 703
+D+ ++ ++L+H H + ++FHP + S DG++ + DLL+ L
Sbjct: 213 WDVRVN----KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL------DLLEGRL 262
Query: 704 LVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
+ ++ G V T V F S GAD V L+
Sbjct: 263 IYTLQGHTGPVFT-------VSFSKGGELFASGGADTQVLLW 297
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/289 (22%), Positives = 116/289 (40%), Gaps = 42/289 (14%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 461
P +A Y GH D+V + SP G L S S D ++RLW +P K
Sbjct: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW----------IP----DKRGK 94
Query: 462 WNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEE 521
++ A +V+ S A G L S D+ + + +
Sbjct: 95 FSEFKAHTAPVRSVDFS------ADGQFLATASEDKSIKVW---------------SMYR 133
Query: 522 ERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQ 581
+R + R H + + GR ++++ + I + ++ + F S G
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGR-----LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 582 VQRVAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 640
V F+P+ + A S ++V+++ + +L + + V+ ++ HP+G+ +I S
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 641 DSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
D L DL L + L+ H + V+F LFASG D V++
Sbjct: 249 DGTLKILDL-LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 53.1 bits (126), Expect = 9e-07
Identities = 24/58 (41%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 409 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNPS 465
YRGHS VRCL SP G+WL S +DD +++LW++ + + P G V V ++P+
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN 200
Score = 50.1 bits (118), Expect = 8e-06
Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 17/166 (10%)
Query: 582 VQRVAFHPARPFLLVASQR-SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 640
V+ V + ++ SQ S+R++ L ++ + LM + + SL HP G+ V GS
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 641 DSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQ 700
D+ + +D+ +R R H +A+R + F P AS +DD H + DL
Sbjct: 126 DTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSPDGKWLASAADD------HTVKLWDLTA 178
Query: 701 NPLLVPVKVLKGHVLTRDLGVLDVI-FHPTQPWVFSSGADGTVRLF 745
++ GH G ++V+ FHP + + S +D T+R +
Sbjct: 179 GKMM---SEFPGHT-----GPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 38.9 bits (89), Expect = 0.018
Identities = 57/248 (22%), Positives = 100/248 (40%), Gaps = 46/248 (18%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 461
P C + GH+ V + ++ + +V+GS GS+R+W++ A+ +RT
Sbjct: 53 PNC-IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRT----------- 100
Query: 462 WNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEE 521
L+ L +P G+ + +GS D + + +
Sbjct: 101 --------LMGHKANICSLDFHP-YGEFVASGSQDTNIKLW------------------D 133
Query: 522 ERQVGLRLRI-CHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG 580
R+ G R H + V + + G +LA A HT V + L+ + S F G
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLA--SAADDHT-VKLWDLTAGKMMSEFPGHTG 190
Query: 581 QVQRVAFHPARPFLLV--ASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICG 638
V V FHP +LL +S R++R + L + ++ + V S+ +P G + G
Sbjct: 191 PVNVVEFHP-NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Query: 639 SYDSKLVW 646
DS V+
Sbjct: 250 CQDSLRVY 257
Score = 34.7 bits (78), Expect = 0.33
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 379 MRVNVDPEDLIPKLPRPRDLQPFPTCQALVYR---GHSDLVRCLSVSPGGQWLVSGSDDG 435
+R+N PE+LI + ++ + A + R GH + L P G+++ SGS D
Sbjct: 69 VRLNT-PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 436 SLRLWEVATARCV 448
+++LW++ CV
Sbjct: 128 NIKLWDIRRKGCV 140
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/284 (24%), Positives = 108/284 (38%), Gaps = 32/284 (11%)
Query: 409 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAV 468
+R H V +++ ++ SG D + W++ + P G SV +
Sbjct: 494 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---LSMDPYDGYDPSVLSH----- 545
Query: 469 CLVAAAVEDSV--LLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 526
V D+V L +P RL + S D + + P P + ASE
Sbjct: 546 --VLEGHGDAVWGLAFSPT-SQRLASCSADGTVRIWDPSSSSPACLCTFPTASE------ 596
Query: 527 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG--QVQR 584
HG P T V + V G T + ++ R S G Q+ +
Sbjct: 597 ------HGVP-TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 649
Query: 585 VAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 643
V HP +P + A R +R + ++ + V+ LAV P G ++ GS+D
Sbjct: 650 VVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCS 709
Query: 644 LVWFDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDD 684
L + LD T + H H++A+ AVA HP L AS D
Sbjct: 710 LRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 753
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 466
H D V CL+V P G +L+SGS D SLRLW + CV+ + + +VA +PS
Sbjct: 685 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 744
Query: 467 AVCLVAAAVEDSV 479
A L+A+A D++
Sbjct: 745 A--LIASAGADAL 755
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATA--RCVRTVPVG---GV 456
P+ + V GH D V L+ SP Q L S S DG++R+W+ +++ C+ T P GV
Sbjct: 540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 599
Query: 457 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLV 491
SVA+ + +VA+ +L + +G L+
Sbjct: 600 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALL 634
Score = 35.8 bits (81), Expect = 0.15
Identities = 78/346 (22%), Positives = 126/346 (36%), Gaps = 38/346 (10%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 469
R H D +R L+ L++ S+DG+L+LW + A + V A+
Sbjct: 442 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV 501
Query: 470 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 529
L A +S + +G D + ++ P+ + P + S V +
Sbjct: 502 LAVAMGSNS---------EYCYSGGADACIHSWKIPDLS-MDPYDGYDPS-----VLSHV 546
Query: 530 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRS--HGQVQRVAF 587
HG V + + LA A G ++ S F + HG VAF
Sbjct: 547 LEGHGDAVWGLAFSPTSQRLASCSA-DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 605
Query: 588 HPARPFLLVASQRS--VRLYH------LLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 639
P +VAS RS LY LL E P ++ + HP I
Sbjct: 606 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAH 663
Query: 640 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 699
D + + D + + KP + H A+ +A P SGS D S+ + L
Sbjct: 664 DDRGIRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS-------L 715
Query: 700 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
N V + + H + + V HP++ + S+GAD ++F
Sbjct: 716 DNKTCV--QEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/284 (24%), Positives = 108/284 (38%), Gaps = 32/284 (11%)
Query: 409 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAV 468
+R H V +++ ++ SG D + W++ + P G SV +
Sbjct: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---LSMDPYDGYDPSVLSH----- 538
Query: 469 CLVAAAVEDSV--LLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 526
V D+V L +P RL + S D + + P P + ASE
Sbjct: 539 --VLEGHGDAVWGLAFSPT-SQRLASCSADGTVRIWDPSSSSPACLCTFPTASE------ 589
Query: 527 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG--QVQR 584
HG P T V + V G T + ++ R S G Q+ +
Sbjct: 590 ------HGVP-TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 642
Query: 585 VAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 643
V HP +P + A R +R + ++ + V+ LAV P G ++ GS+D
Sbjct: 643 VVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCS 702
Query: 644 LVWFDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDD 684
L + LD T + H H++A+ AVA HP L AS D
Sbjct: 703 LRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 466
H D V CL+V P G +L+SGS D SLRLW + CV+ + + +VA +PS
Sbjct: 678 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 737
Query: 467 AVCLVAAAVEDSV 479
A L+A+A D++
Sbjct: 738 A--LIASAGADAL 748
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATA--RCVRTVPVG---GV 456
P+ + V GH D V L+ SP Q L S S DG++R+W+ +++ C+ T P GV
Sbjct: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592
Query: 457 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLV 491
SVA+ + +VA+ +L + +G L+
Sbjct: 593 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALL 627
Score = 35.8 bits (81), Expect = 0.15
Identities = 78/346 (22%), Positives = 126/346 (36%), Gaps = 38/346 (10%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 469
R H D +R L+ L++ S+DG+L+LW + A + V A+
Sbjct: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV 494
Query: 470 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 529
L A +S + +G D + ++ P+ + P + S V +
Sbjct: 495 LAVAMGSNS---------EYCYSGGADACIHSWKIPDLS-MDPYDGYDPS-----VLSHV 539
Query: 530 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRS--HGQVQRVAF 587
HG V + + LA A G ++ S F + HG VAF
Sbjct: 540 LEGHGDAVWGLAFSPTSQRLASCSA-DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 598
Query: 588 HPARPFLLVASQRS--VRLYH------LLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 639
P +VAS RS LY LL E P ++ + HP I
Sbjct: 599 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAH 656
Query: 640 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 699
D + + D + + KP + H A+ +A P SGS D S+ + L
Sbjct: 657 DDRGIRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS-------L 708
Query: 700 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
N V + + H + + V HP++ + S+GAD ++F
Sbjct: 709 DNKTCV--QEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/113 (31%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 576 RRSHGQVQRVA---FHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPA 631
R HG + V HP L+ S+ S R++ + + L + V+++ A
Sbjct: 282 RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAA 341
Query: 632 GDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDD 684
+I GS+D+ + +DL ++ K L +HKK++RAV HPR+ FASGS D
Sbjct: 342 EPQIITGSHDTTIRLWDL-VAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD 393
Score = 50.4 bits (119), Expect = 6e-06
Identities = 21/57 (36%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 390 PKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATAR 446
P +P+P+ P+ + V GH VRC++V PG QW V+GS D ++++W++A+ +
Sbjct: 183 PTMPKPQWHPPWKLYR--VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGK 237
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 16/125 (12%)
Query: 622 WVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYP-LFAS 680
WV +AV P + GS D + +DL S K L H +R V R P LF+
Sbjct: 206 WVRCIAVEPGNQWFVTGSADRTIKIWDL-ASGKLKLSLTGHISTVRGVIVSTRSPYLFSC 264
Query: 681 GSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADG 740
G D + C + YN ++++ GH+ V + HPT + + D
Sbjct: 265 GED--KQVKCWDLEYNKVIRH--------YHGHL----SAVYGLDLHPTIDVLVTCSRDS 310
Query: 741 TVRLF 745
T R++
Sbjct: 311 TARIW 315
Score = 32.7 bits (73), Expect = 1.3
Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 13/90 (14%)
Query: 654 KPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGH 713
K YR++ H +R +A P F +GS D ++ + DL L + L GH
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIW------DLASGKLKLS---LTGH 245
Query: 714 VLTRDLGVLDVIFHPTQPWVFSSGADGTVR 743
+ T V VI P++FS G D V+
Sbjct: 246 IST----VRGVIVSTRSPYLFSCGEDKQVK 271
Score = 31.6 bits (70), Expect = 2.8
Identities = 14/34 (41%), Positives = 24/34 (70%), Gaps = 1/34 (2%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT 444
GH+ ++ L+V+ G LVSG+D+G++ LW+ T
Sbjct: 411 GHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRT 443
Score = 30.8 bits (68), Expect = 4.8
Identities = 16/43 (37%), Positives = 22/43 (51%)
Query: 409 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 451
Y GH V L + P LV+ S D + R+W+V T V T+
Sbjct: 284 YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTL 326
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/69 (37%), Positives = 43/69 (62%), Gaps = 2/69 (2%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT-VPVGGVVKSVAWNPSPAVCL 470
H + VRC SP G+ +VS SDD +++LW+ ++ CV + GG V V ++PS C+
Sbjct: 106 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS-GTCI 164
Query: 471 VAAAVEDSV 479
AA ++++V
Sbjct: 165 AAAGMDNTV 173
Score = 48.5 bits (114), Expect = 2e-05
Identities = 68/297 (22%), Positives = 107/297 (36%), Gaps = 58/297 (19%)
Query: 402 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 461
P +A + GH D V C++ SP G L SGS D +TV +
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD--------------KTVRI-------- 49
Query: 462 WNPS----PAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPA 513
W P+ V A SV + G V S D+ + + + L Q
Sbjct: 50 WVPNVKGESTVFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWATHRQKFLFSLSQHI 107
Query: 514 RWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQS 573
W+ ++ GR ++++ V + S R
Sbjct: 108 NWVRCAKFSPD-------------------GR-----LIVSASDDKTVKLWDKSSRECVH 143
Query: 574 PFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 632
+ G V V FHP+ + A +V+++ + L + + V+ L+ HP+G
Sbjct: 144 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 203
Query: 633 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
+ +I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 204 NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Score = 36.6 bits (83), Expect = 0.087
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 575 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 633
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 634 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 693
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 121 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 694 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 744
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 180 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 50.4 bits (119), Expect = 6e-06
Identities = 81/356 (22%), Positives = 141/356 (39%), Gaps = 47/356 (13%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNPSPAVC 469
GHS+ V ++ SP G++L SGS D ++R W+++T T V S++W+P
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK- 170
Query: 470 LVAAAVEDSVLLLNPALG---DRLVAGSTDQLLS-AFVPPEEPPLQPARWLEASEEERQV 525
L + +LL +P+ G R +AG + + ++ P P R++ +S ++ V
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP--ECRYVASSSKDGSV 228
Query: 526 GL---------RLRICHGKPVTQVTWHGRGDYLA-----VVLATQGHTQVLIHQLSRRRS 571
+ R+ H + VT + W G G + + + H VL L
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288
Query: 572 --QSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVH 629
+ + ++ AF PA AS L L QEL ++ + V
Sbjct: 289 WVNTMALSTDYALRTGAFEPAE-----ASVNPQDLQGSL-QELKERALSRYNLVRG---- 338
Query: 630 PAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
+ ++ GS D L + KP + H+ + V F P + AS S D S+ +
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKL 398
Query: 690 CHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
G L L+GHV V + + + S +D T++++
Sbjct: 399 WDGRTGKYLAS---------LRGHV----AAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 34.7 bits (78), Expect = 0.33
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 464
RGH V ++ S + LVSGS D +L++W+V + +P V +V W+P
Sbjct: 411 RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP 466
Score = 33.1 bits (74), Expect = 0.96
Identities = 32/134 (23%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
Query: 613 TKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFH 672
T L + + V S+A P G + GS D+ + ++DL T P+ + H+ + ++++
Sbjct: 107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET-PHFTCKGHRHWVLSISWS 165
Query: 673 PRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGH-VLTRDLGVLDVIFHPTQP 731
P ASG +G +++ + + L GH L + +P
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQV--------GRTLAGHSKWITGLSWEPLHANPECR 217
Query: 732 WVFSSGADGTVRLF 745
+V SS DG+VR++
Sbjct: 218 YVASSSKDGSVRIW 231
Score = 32.0 bits (71), Expect = 2.1
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLW 440
GH+D V + SP GQ + SG D LR+W
Sbjct: 454 GHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/102 (28%), Positives = 55/102 (53%), Gaps = 11/102 (10%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 468
+GHS+ V C + +P +VSGS D S+R+W+V T +C++T+P V +V +N ++
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 469 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 510
+V+++ + + + A G Q L + + PP+
Sbjct: 186 -IVSSSYDGLCRIWDTASG---------QCLKTLIDDDNPPV 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 409 YRGHSDLVRCLSVS---PGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 464
Y GH + C+ + GG+W+VSGS+D + +W + T V+ + VV S A +P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 465 SPAVCLVAAAVEDSVLLL 482
+ + AA D + L
Sbjct: 312 TENIIASAALENDKTIKL 329
Score = 37.4 bits (85), Expect = 0.051
Identities = 21/78 (26%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 469
GH+ V + SP G+WL S S D +++W + +T+ + + VAW+ S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101
Query: 470 LVAAAVEDSVLLLNPALG 487
LV+A+ + ++ + + + G
Sbjct: 102 LVSASDDKTLKIWDVSSG 119
Score = 34.7 bits (78), Expect = 0.33
Identities = 14/41 (34%), Positives = 27/41 (65%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 451
GH + ++ S LVS SDD +L++W+V++ +C++T+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Score = 31.6 bits (70), Expect = 2.8
Identities = 10/35 (28%), Positives = 24/35 (68%)
Query: 416 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT 450
V + SP G+++++ + D +L+LW+ + +C++T
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/102 (28%), Positives = 55/102 (53%), Gaps = 11/102 (10%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 468
+GHS+ V C + +P +VSGS D S+R+W+V T +C++T+P V +V +N ++
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 469 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 510
+V+++ + + + A G Q L + + PP+
Sbjct: 186 -IVSSSYDGLCRIWDTASG---------QCLKTLIDDDNPPV 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 409 YRGHSDLVRCLSVS---PGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 464
Y GH + C+ + GG+W+VSGS+D + +W + T V+ + VV S A +P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 465 SPAVCLVAAAVEDSVLLL 482
+ + AA D + L
Sbjct: 312 TENIIASAALENDKTIKL 329
Score = 37.4 bits (85), Expect = 0.051
Identities = 21/78 (26%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 469
GH+ V + SP G+WL S S D +++W + +T+ + + VAW+ S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101
Query: 470 LVAAAVEDSVLLLNPALG 487
LV+A+ + ++ + + + G
Sbjct: 102 LVSASDDKTLKIWDVSSG 119
Score = 34.7 bits (78), Expect = 0.33
Identities = 14/41 (34%), Positives = 27/41 (65%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 451
GH + ++ S LVS SDD +L++W+V++ +C++T+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Score = 31.6 bits (70), Expect = 2.8
Identities = 10/35 (28%), Positives = 24/35 (68%)
Query: 416 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT 450
V + SP G+++++ + D +L+LW+ + +C++T
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/172 (26%), Positives = 73/172 (42%), Gaps = 15/172 (8%)
Query: 575 FRRSHGQVQRVAFHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 633
F +V+ ++FHP RP++L + V +L+ L K + V + H
Sbjct: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
Query: 634 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 693
+ G D K+ ++ L + +L H +R FH YP S SDD ++ V +
Sbjct: 65 LFVSGGDDYKIKVWNYKLRRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 694 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
V VL GH + V+ FHPT+ V S+ D TVR++
Sbjct: 124 ---------SRTCVCVLTGH----NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 43.9 bits (102), Expect = 5e-04
Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 39/192 (20%)
Query: 582 VQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 640
++ FH P++L AS +++R+++ + L + +V HP D V+ S
Sbjct: 96 IRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL 155
Query: 641 DSKLVWFDL-----------------------DLSTKPYRMLRH----HKKALRAVAFHP 673
D + +D+ DL +++H H + + AFHP
Sbjct: 156 DQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
Query: 674 RYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWV 733
PL SG+DD V + + V +GH V +FHP Q +
Sbjct: 216 TMPLIVSGADDRQVKIWR-------MNESKAWEVDTCRGHY----NNVSCAVFHPRQELI 264
Query: 734 FSSGADGTVRLF 745
S+ D ++R++
Sbjct: 265 LSNSEDKSIRVW 276
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/283 (19%), Positives = 98/283 (34%), Gaps = 62/283 (21%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCL 470
GH D +R W++S SDD ++R+W W VC+
Sbjct: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWN--------------------WQSRTCVCV 130
Query: 471 VAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLR 530
+ + D +V+ S DQ + W + ++ +
Sbjct: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRV-------------WDISGLRKKNLSPGAV 177
Query: 531 ICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPA 590
+ +T V G D + V +GH + V AFHP
Sbjct: 178 ESDVRGITGVDLFGTTDAV-VKHVLEGHDR--------------------GVNWAAFHPT 216
Query: 591 RPFLLV-ASQRSVRLYHLLRQELTKKLMPNCKW----VSSLAVHPAGDNVICGSYDSKLV 645
P ++ A R V+++ + + + + C+ VS HP + ++ S D +
Sbjct: 217 MPLIVSGADDRQVKIWRMNESKAWE--VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIR 274
Query: 646 WFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVI 688
+D+ T R H + +A HP LFA+G D G ++
Sbjct: 275 VWDMSKRTGVQTFRRDHDR-FWVLAAHPNLNLFAAGHDGGMIV 316
Score = 32.7 bits (73), Expect = 1.3
Identities = 45/197 (22%), Positives = 76/197 (38%), Gaps = 31/197 (15%)
Query: 403 TCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAW 462
TC V GH+ V C P +VS S D ++R+W+++ R P G V V
Sbjct: 126 TC-VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP-GAVESDVRG 183
Query: 463 NPSPAVCLVAAAVEDSVL----------LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQP 512
+ AV VL +P + +V+G+ D+ + + E
Sbjct: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTM-PLIVSGADDRQVKIWRMNES----- 237
Query: 513 ARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQ 572
+A E + G H V+ +H R + ++L+ + + +S+R
Sbjct: 238 ----KAWEVDTCRG------HYNNVSCAVFHPRQE---LILSNSEDKSIRVWDMSKRTGV 284
Query: 573 SPFRRSHGQVQRVAFHP 589
FRR H + +A HP
Sbjct: 285 QTFRRDHDRFWVLAAHP 301
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/172 (26%), Positives = 73/172 (42%), Gaps = 15/172 (8%)
Query: 575 FRRSHGQVQRVAFHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 633
F +V+ ++FHP RP++L + V +L+ L K + V + H
Sbjct: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
Query: 634 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 693
+ G D K+ ++ L + +L H +R FH YP S SDD ++ V +
Sbjct: 65 LFVSGGDDYKIKVWNYKLRRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 694 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
V VL GH + V+ FHPT+ V S+ D TVR++
Sbjct: 124 ---------SRTCVCVLTGH----NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 43.9 bits (102), Expect = 5e-04
Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 39/192 (20%)
Query: 582 VQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 640
++ FH P++L AS +++R+++ + L + +V HP D V+ S
Sbjct: 96 IRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL 155
Query: 641 DSKLVWFDL-----------------------DLSTKPYRMLRH----HKKALRAVAFHP 673
D + +D+ DL +++H H + + AFHP
Sbjct: 156 DQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
Query: 674 RYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWV 733
PL SG+DD V + + V +GH V +FHP Q +
Sbjct: 216 TMPLIVSGADDRQVKIWR-------MNESKAWEVDTCRGHY----NNVSCAVFHPRQELI 264
Query: 734 FSSGADGTVRLF 745
S+ D ++R++
Sbjct: 265 LSNSEDKSIRVW 276
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/283 (19%), Positives = 98/283 (34%), Gaps = 62/283 (21%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCL 470
GH D +R W++S SDD ++R+W W VC+
Sbjct: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWN--------------------WQSRTCVCV 130
Query: 471 VAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLR 530
+ + D +V+ S DQ + W + ++ +
Sbjct: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRV-------------WDISGLRKKNLSPGAV 177
Query: 531 ICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPA 590
+ +T V G D + V +GH + V AFHP
Sbjct: 178 ESDVRGITGVDLFGTTDAV-VKHVLEGHDR--------------------GVNWAAFHPT 216
Query: 591 RPFLLV-ASQRSVRLYHLLRQELTKKLMPNCKW----VSSLAVHPAGDNVICGSYDSKLV 645
P ++ A R V+++ + + + + C+ VS HP + ++ S D +
Sbjct: 217 MPLIVSGADDRQVKIWRMNESKAWE--VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIR 274
Query: 646 WFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVI 688
+D+ T R H + +A HP LFA+G D G ++
Sbjct: 275 VWDMSKRTGVQTFRRDHDR-FWVLAAHPNLNLFAAGHDGGMIV 316
Score = 32.7 bits (73), Expect = 1.3
Identities = 45/197 (22%), Positives = 76/197 (38%), Gaps = 31/197 (15%)
Query: 403 TCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAW 462
TC V GH+ V C P +VS S D ++R+W+++ R P G V V
Sbjct: 126 TC-VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP-GAVESDVRG 183
Query: 463 NPSPAVCLVAAAVEDSVL----------LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQP 512
+ AV VL +P + +V+G+ D+ + + E
Sbjct: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTM-PLIVSGADDRQVKIWRMNES----- 237
Query: 513 ARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQ 572
+A E + G H V+ +H R + ++L+ + + +S+R
Sbjct: 238 ----KAWEVDTCRG------HYNNVSCAVFHPRQE---LILSNSEDKSIRVWDMSKRTGV 284
Query: 573 SPFRRSHGQVQRVAFHP 589
FRR H + +A HP
Sbjct: 285 QTFRRDHDRFWVLAAHP 301
>gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens]
Length = 296
Score = 47.4 bits (111), Expect = 5e-05
Identities = 19/46 (41%), Positives = 33/46 (71%)
Query: 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 453
V RGH+D + CL++ ++SG +DG++RLW++ TA+ V+T+ V
Sbjct: 163 VLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEV 208
Score = 33.5 bits (75), Expect = 0.74
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 623 VSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGS 682
+++L + P +++I D +L DL+ T R+LR H + +A R P SG
Sbjct: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFT-RVLRGHTDYIHCLALRERSPEVLSGG 187
Query: 683 DDGSV 687
+DG+V
Sbjct: 188 EDGAV 192
>gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens]
Length = 341
Score = 47.4 bits (111), Expect = 5e-05
Identities = 19/46 (41%), Positives = 33/46 (71%)
Query: 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 453
V RGH+D + CL++ ++SG +DG++RLW++ TA+ V+T+ V
Sbjct: 163 VLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEV 208
Score = 33.5 bits (75), Expect = 0.74
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 623 VSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGS 682
+++L + P +++I D +L DL+ T R+LR H + +A R P SG
Sbjct: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFT-RVLRGHTDYIHCLALRERSPEVLSGG 187
Query: 683 DDGSV 687
+DG+V
Sbjct: 188 EDGAV 192
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 46.6 bits (109), Expect = 8e-05
Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 11/102 (10%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 468
+GHS+ V C + +P ++SGS D ++++WEV T +C++T+ V +V +N S +
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS- 180
Query: 469 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 510
L+ + D + R+ ++ Q L V + PP+
Sbjct: 181 -LIVSGSYDGLC--------RIWDAASGQCLKTLVDDDNPPV 213
Score = 37.0 bits (84), Expect = 0.067
Identities = 61/282 (21%), Positives = 117/282 (41%), Gaps = 14/282 (4%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 469
GH++ V + SP G+WL S S D + +W + +T+ + + VAW+ S +
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS-SDSSR 97
Query: 470 LVAAAVEDSVLLLNPALGD--RLVAGSTDQLLSA-FVPPEEPPLQPA--RWLEASEEERQ 524
LV+A+ + ++ L + G + + G ++ + F PP + + ++ E +
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 525 VGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQR 584
L+ H PV+ V ++ G +V + + S + ++ + V
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGS--LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 585 VAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLM--PNCKWVSSLAVHPAGDNVICGSYD 641
V F P ++L A+ +++L+ R K N K+ G I +
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
Query: 642 SKLVWFDLDLSTKP-YRMLRHHKKALRAVAFHPRYPLFASGS 682
LV+ +L TK + L+ H + + A HP L AS +
Sbjct: 276 DNLVYI-WNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/238 (22%), Positives = 95/238 (39%), Gaps = 42/238 (17%)
Query: 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSP 466
+++ H + +R S SP + SDDG++R+W+ R + G VK V W+P+
Sbjct: 197 MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTK 256
Query: 467 AVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 526
+ +V+GS D QP ++ + +
Sbjct: 257 GL---------------------VVSGSKDS------------QQPIKFWDPKTGQSLAT 283
Query: 527 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVA 586
L H V +V + G++L + A++ H L + + FR + VA
Sbjct: 284 LH---AHKNTVMEVKLNLNGNWL--LTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVA 338
Query: 587 FHPARPFLLVA--SQRSVRLYHL-LRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYD 641
+HP L + S S+ +H+ + +E+ M + + SLA HP G + GS D
Sbjct: 339 WHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 577 RSHG-QVQRVAFHPARPFLLVAS---QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 632
R HG V+ V +HP + ++ S Q+ ++ + + L + V + ++ G
Sbjct: 241 RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG 300
Query: 633 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYP-LFASGSDDGSVIVCH 691
+ ++ S D FD+ + ++ R HKK AVA+HP + LFASG DGS++ H
Sbjct: 301 NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 23/88 (26%)
Query: 657 RMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV-----CHGMVYNDLLQNPLLVPVKVLK 711
+M + HK+A+R +F P FA+ SDDG+V + CH ++L+
Sbjct: 196 KMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCH--------------EERILR 241
Query: 712 GHVLTRDLGVLDVIFHPTQPWVFSSGAD 739
GH V V +HPT+ V S D
Sbjct: 242 GH----GADVKCVDWHPTKGLVVSGSKD 265
Score = 31.2 bits (69), Expect = 3.7
Identities = 35/156 (22%), Positives = 68/156 (43%), Gaps = 6/156 (3%)
Query: 533 HGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARP 592
HG V V WH L V + + +S + V V +
Sbjct: 243 HGADVKCVDWHPTKG-LVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGN 301
Query: 593 FLLVASQRSV-RLYHL--LRQELTKKLMPNCKWVSSLAVHPAGDNVIC-GSYDSKLVWFD 648
+LL AS+ + +L+ + L++EL + + K +++A HP + + G D L+++
Sbjct: 302 WLLTASRDHLCKLFDIRNLKEEL-QVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360
Query: 649 LDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDD 684
+ + + M H+ + ++A+HP + SGS+D
Sbjct: 361 VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
>gi|134133292 WD repeat domain 27 [Homo sapiens]
Length = 857
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/295 (23%), Positives = 118/295 (40%), Gaps = 38/295 (12%)
Query: 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPA 467
V+ GH V + S +WL+S + DG+LR+W A + K + P +
Sbjct: 580 VFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG-----KDMFSKPIQS 634
Query: 468 VCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGL 527
D+ +LL+ +G QLL + + ++ R+ + S+ + L
Sbjct: 635 AQFYYI---DAFILLS--------SGPEFQLLRYHIDTCKDEIK--RYKQKSKSK----L 677
Query: 528 RLRICHGKPVTQVTWHGRGDYLA-VVLATQGHTQVLIHQLSRRRSQSPFRRSHG------ 580
R+ V + D+ + +VLA + V + L+ S + +H
Sbjct: 678 ICRLSTTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAVIAEAHSRPVHQI 737
Query: 581 -QVQRVAFHPARP-----FLLVASQRSVRLYHL--LRQELTKKLMPNCKWVSSLAVHPAG 632
Q + +F +P FL A +RL+ L LR E + P + +A P G
Sbjct: 738 CQNKGSSFTTQQPQAYNLFLTTAIGDGMRLWDLRTLRCERHFEGHPTRGYPCGIAFSPCG 797
Query: 633 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 687
CG+ D +++ ST +R L H + VAF+P P A+ + DG +
Sbjct: 798 RFAACGAEDRHAYVYEMGSSTFSHR-LAGHTDTVTGVAFNPSAPQLATATLDGKL 851
>gi|4758876 poly(A) binding protein, nuclear 1 [Homo sapiens]
Length = 306
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/101 (33%), Positives = 45/101 (44%), Gaps = 17/101 (16%)
Query: 2 AGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFS 61
AG G G + + PE+ EPE EPEPE EPP P + G SG S+E
Sbjct: 43 AGDYGNG-LESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQE---- 97
Query: 62 GLEDSGSDSSEDDDEGDEEGE--DGALDDEGHSGIKKTTEE 100
E+++ G EG+ DGA++D IK E
Sbjct: 98 ----------EEEEPGLVEGDPGDGAIEDPELEAIKARVRE 128
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 44.7 bits (104), Expect = 3e-04
Identities = 69/270 (25%), Positives = 109/270 (40%), Gaps = 22/270 (8%)
Query: 392 LPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATAR---CV 448
L RP + FP L RGH V C S S G L +G D SL W+V T + +
Sbjct: 2042 LTRPHKAEDFPCGTEL--RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLI 2099
Query: 449 RTVPV--GGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQ-LLSAFVPP 505
+ P V AW L++ + + SV L +P G RL Q +SA
Sbjct: 2100 HSFPACHRDWVTGCAWTKDN--LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAV 2157
Query: 506 EEPPLQPARWLEASEEERQ-VGLRLRICHGKPVT--------QVTWHGRGDYLAVVLATQ 556
EE + +R + Q V L H P++ + + L V +
Sbjct: 2158 EEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217
Query: 557 GHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKK 615
G T+ L H L ++ + S G V+ A +L AS+ SVRL+ + ++
Sbjct: 2218 GATR-LWHPLLVCQTHTLLGHS-GPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTC 2275
Query: 616 LMPNCKWVSSLAVHPAGDNVICGSYDSKLV 645
+ + V+++A P G + G+ +L+
Sbjct: 2276 IPRSSAAVTAVAWAPDGSMAVSGNQAGELI 2305
Score = 30.4 bits (67), Expect = 6.2
Identities = 17/61 (27%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 413 SDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVA 472
S V ++ +P G VSG+ G L LW+ A+ V T G + ++ W+ + +++
Sbjct: 2280 SAAVTAVAWAPDGSMAVSGNQAGELILWQ--EAKAVATAQAPGHIGALIWSSAHTFFVLS 2337
Query: 473 A 473
A
Sbjct: 2338 A 2338
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 403 TCQALV-YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 453
TC L+ +GH+D V+ L ++ G +SGS DG++RLW + RC+ T V
Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 409 YRGHSDLVRCLSVSPGGQWL-VSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNP 464
YRGH D V L P L V+ S D ++R+W+V T +C+ TV G ++ W+P
Sbjct: 95 YRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSP 151
Score = 30.8 bits (68), Expect = 4.8
Identities = 12/32 (37%), Positives = 18/32 (56%)
Query: 418 CLSVSPGGQWLVSGSDDGSLRLWEVATARCVR 449
C+ P G++ +GS D + LW+V CVR
Sbjct: 229 CIKFDPMGKYFATGSADALVSLWDVDELVCVR 260
Score = 30.4 bits (67), Expect = 6.2
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 416 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAV 475
VR LS S G+ L S S+D + + EV T + V +VAW+P L+A A
Sbjct: 269 VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRP--LLAFAC 326
Query: 476 ED 477
+D
Sbjct: 327 DD 328
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 43.9 bits (102), Expect = 5e-04
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 21/111 (18%)
Query: 408 VYRGHSD-LVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV--PVGGVVKS----- 459
V +GH D ++ CL G +VSGSDD +L++W T +C+RT+ GGV S
Sbjct: 257 VLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 314
Query: 460 -----------VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLL 499
WN C+ S + R+V+GS D L
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATL 365
Score = 37.0 bits (84), Expect = 0.067
Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 20/104 (19%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARC----------VRTVPVGG--VVK 458
GH+ VRC+ + + +VSGS D +LR+W++ T +C VR V G VV
Sbjct: 341 GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVS 398
Query: 459 SV------AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTD 496
W+P CL + + G +V+GS D
Sbjct: 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLD 442
Score = 36.6 bits (83), Expect = 0.087
Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 10/79 (12%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV------GGVVKSVAWNPS 465
H V CL + ++++ SDDG+++LW++ T +R + GGVV + + +
Sbjct: 505 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNT 562
Query: 466 PAVCLVAA--AVEDSVLLL 482
VC V + E++ LL+
Sbjct: 563 KLVCAVGSRNGTEETKLLV 581
Score = 34.7 bits (78), Expect = 0.33
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 451
+GH++ R S+ G +VSGS D S+R+W+V T C+ T+
Sbjct: 420 QGHTN--RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 459
Score = 30.4 bits (67), Expect = 6.2
Identities = 9/24 (37%), Positives = 20/24 (83%)
Query: 428 LVSGSDDGSLRLWEVATARCVRTV 451
LVSG+ D ++++W++ T +C++T+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTL 499
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 43.9 bits (102), Expect = 5e-04
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 21/111 (18%)
Query: 408 VYRGHSD-LVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV--PVGGVVKS----- 459
V +GH D ++ CL G +VSGSDD +L++W T +C+RT+ GGV S
Sbjct: 375 VLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 432
Query: 460 -----------VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLL 499
WN C+ S + R+V+GS D L
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATL 483
Score = 37.0 bits (84), Expect = 0.067
Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 20/104 (19%)
Query: 411 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARC----------VRTVPVGG--VVK 458
GH+ VRC+ + + +VSGS D +LR+W++ T +C VR V G VV
Sbjct: 459 GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVS 516
Query: 459 SV------AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTD 496
W+P CL + + G +V+GS D
Sbjct: 517 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLD 560
Score = 36.6 bits (83), Expect = 0.087
Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 10/79 (12%)
Query: 412 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV------GGVVKSVAWNPS 465
H V CL + ++++ SDDG+++LW++ T +R + GGVV + + +
Sbjct: 623 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNT 680
Query: 466 PAVCLVAA--AVEDSVLLL 482
VC V + E++ LL+
Sbjct: 681 KLVCAVGSRNGTEETKLLV 699
Score = 34.7 bits (78), Expect = 0.33
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 451
+GH++ R S+ G +VSGS D S+R+W+V T C+ T+
Sbjct: 538 QGHTN--RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 577
Score = 30.4 bits (67), Expect = 6.2
Identities = 9/24 (37%), Positives = 20/24 (83%)
Query: 428 LVSGSDDGSLRLWEVATARCVRTV 451
LVSG+ D ++++W++ T +C++T+
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTL 617
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,318,722
Number of Sequences: 37866
Number of extensions: 1866790
Number of successful extensions: 13787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 256
Number of HSP's successfully gapped in prelim test: 316
Number of HSP's that attempted gapping in prelim test: 10083
Number of HSP's gapped (non-prelim): 2835
length of query: 746
length of database: 18,247,518
effective HSP length: 110
effective length of query: 636
effective length of database: 14,082,258
effective search space: 8956316088
effective search space used: 8956316088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.