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Search of human proteins with 21264345
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264345 peripherin [Homo sapiens]
(470 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264345 peripherin [Homo sapiens] 898 0.0
gi|55749932 desmin [Homo sapiens] 514 e-146
gi|62414289 vimentin [Homo sapiens] 501 e-142
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 437 e-123
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 409 e-114
gi|14249342 internexin neuronal intermediate filament protein, a... 377 e-105
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 337 1e-92
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 325 7e-89
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 266 3e-71
gi|4504919 keratin 8 [Homo sapiens] 265 5e-71
gi|119395754 keratin 5 [Homo sapiens] 233 3e-61
gi|153791158 keratin 75 [Homo sapiens] 232 5e-61
gi|67782365 keratin 7 [Homo sapiens] 226 4e-59
gi|155969697 keratin 6C [Homo sapiens] 223 4e-58
gi|5031839 keratin 6A [Homo sapiens] 222 5e-58
gi|119703753 keratin 6B [Homo sapiens] 221 1e-57
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 221 1e-57
gi|109255249 keratin 4 [Homo sapiens] 219 3e-57
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 218 9e-57
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap... 218 9e-57
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap... 218 9e-57
gi|14318422 keratin 86 [Homo sapiens] 218 9e-57
gi|169790841 keratin 83 [Homo sapiens] 218 1e-56
gi|28173564 keratin 73 [Homo sapiens] 216 3e-56
gi|4504935 keratin 85 [Homo sapiens] 216 5e-56
gi|109148552 keratin 3 [Homo sapiens] 215 8e-56
gi|169790853 keratin, hair, basic, 1 [Homo sapiens] 215 8e-56
gi|32567786 keratin 6L [Homo sapiens] 211 9e-55
gi|15618995 keratin 71 [Homo sapiens] 209 4e-54
gi|153791670 keratin 76 [Homo sapiens] 209 4e-54
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 898 bits (2321), Expect = 0.0
Identities = 470/470 (100%), Positives = 470/470 (100%)
Query: 1 MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSF 60
MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSF
Sbjct: 1 MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSF 60
Query: 61 RSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQ 120
RSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQ
Sbjct: 61 RSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQ 120
Query: 121 QNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALK 180
QNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALK
Sbjct: 121 QNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALK 180
Query: 181 QRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQ 240
QRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQ
Sbjct: 181 QRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQ 240
Query: 241 VSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANR 300
VSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANR
Sbjct: 241 VSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANR 300
Query: 301 NHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAAR 360
NHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAAR
Sbjct: 301 NHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAAR 360
Query: 361 LEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIK 420
LEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIK
Sbjct: 361 LEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIK 420
Query: 421 TTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSELDKSSAHSY 470
TTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSELDKSSAHSY
Sbjct: 421 TTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSELDKSSAHSY 470
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 514 bits (1323), Expect = e-146
Identities = 277/469 (59%), Positives = 360/469 (76%), Gaps = 31/469 (6%)
Query: 15 TSYRRTFGPPPSL-----------------SPGAFSYSSSSRFSSSRLLGSASPSSSVR- 56
+SYRRTFG P S G+ S +S + SR G A S+R
Sbjct: 12 SSYRRTFGGAPGFPLGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGGLGSLRA 71
Query: 57 --LGSFRSPRA-GAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIE 113
LG+ R+P + GAG LL DFS+A+A+NQEFL TR+NEK ELQELNDRFAN+IE
Sbjct: 72 SRLGTTRTPSSYGAGELL-------DFSLADAVNQEFLTTRTNEKVELQELNDRFANYIE 124
Query: 114 KVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLA 173
KVRFLEQQNAAL E+++ +G+EP R +L ++ELRELRR++E+L +R RV VERD L
Sbjct: 125 KVRFLEQQNAALAAEVNRLKGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNLL 184
Query: 174 EDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHE 233
+DL LK +L+EE + +E+AE+NL FR DVD ATL+R++LER+IESL +EI FLKK+HE
Sbjct: 185 DDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHE 244
Query: 234 EELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYAD 293
EE+R+LQ ++ QQVQ VE++ + KP+LTAALRDIRAQYE+IAAKN+ EAEEWYKSK +D
Sbjct: 245 EEIRELQAQLQEQQVQ-VEMDMS-KPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSD 302
Query: 294 LSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGG 353
L+ AAN+N++ALRQAKQEM E R QIQS TCE+D L+GTN++L+RQ+RELE++FA EA G
Sbjct: 303 LTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASG 362
Query: 354 YQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHS 413
YQ ARLEEE+R LK+EMARHLREYQ+LLNVKMALD+EIATYRKLLEGEESRI++P+ +
Sbjct: 363 YQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQT 422
Query: 414 FASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSEL 462
+++LN + T PE + + H++KTV+IKTIETR+GEVV+E+ ++Q L
Sbjct: 423 YSALNFRETSPE-QRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL 470
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 501 bits (1290), Expect = e-142
Identities = 271/463 (58%), Positives = 358/463 (77%), Gaps = 28/463 (6%)
Query: 13 SSTSYRRTFGPP-----PSLSPG-------AFSYSSSSRFSSSRLLGSASP-------SS 53
SS+SYRR FG P PS S +S S+ R S+SR L ++SP SS
Sbjct: 7 SSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSS 66
Query: 54 SVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIE 113
+VRL RS G +RL + +DFS+A+A+N EF TR+NEK ELQELNDRFAN+I+
Sbjct: 67 AVRL---RSSVPG----VRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYID 119
Query: 114 KVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLA 173
KVRFLEQQN L EL Q +GQ +R L ++E+RELRR+++ L ++ RV+VERD LA
Sbjct: 120 KVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLA 179
Query: 174 EDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHE 233
ED+ L+++L+EE +RE+AE+ L FR+DVD+A+L+RL+LERK+ESL +EI FLKKLHE
Sbjct: 180 EDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHE 239
Query: 234 EELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYAD 293
EE+++LQ ++ Q VQ ++V+ + KP+LTAALRD+R QYES+AAKNLQEAEEWYKSK+AD
Sbjct: 240 EEIQELQAQIQEQHVQ-IDVDVS-KPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFAD 297
Query: 294 LSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGG 353
LS+AANRN++ALRQAKQE E RRQ+QSLTCEVD L+GTNE+L RQ+RE+EE FA+EA
Sbjct: 298 LSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAAN 357
Query: 354 YQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHS 413
YQ RL++E++ +KEEMARHLREYQ+LLNVKMALDIEIATYRKLLEGEESRIS+P+ +
Sbjct: 358 YQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPN 417
Query: 414 FASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQK 456
F+SLN++ T + P D+HS++T+LIKT+ETR+G+V+ E+ +
Sbjct: 418 FSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQ 460
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 437 bits (1125), Expect = e-123
Identities = 226/402 (56%), Positives = 309/402 (76%), Gaps = 8/402 (1%)
Query: 64 RAGAG---ALLRLPSE---RLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRF 117
R G G +L R+P R+DFS+A ALN F TR++E+ E+ ELNDRFA++IEKVRF
Sbjct: 30 RLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRF 89
Query: 118 LEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLA 177
LEQQN AL EL+Q R +EP + + Q ELRELR L+ L R++VERD LA+DLA
Sbjct: 90 LEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLA 149
Query: 178 ALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 237
++Q+L++ET R +AE+NL +R++ D+ATL+RL+LERKIESL +EI FL+K+HEEE+R
Sbjct: 150 TVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVR 209
Query: 238 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDA 297
+LQ + QQV VE++ KP+LTAAL++IR QYE++A+ N+ EAEEWY+SK+ADL+DA
Sbjct: 210 ELQEQLARQQVH-VELDVA-KPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDA 267
Query: 298 ANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAG 357
A RN E LRQAK E N+ RRQ+QSLTC+++ LRGTNE+L RQ+RE EE+ EA YQ
Sbjct: 268 AARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEA 327
Query: 358 AARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASL 417
ARLEEE + LK+EMARHL+EYQ+LLNVK+ALDIEIATYRKLLEGEE+RI++PV +F++L
Sbjct: 328 LARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
Query: 418 NIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQR 459
I+ T + + + H ++ +++KT+E R+GEV+ ES++E +
Sbjct: 388 QIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHK 429
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 409 bits (1050), Expect = e-114
Identities = 219/396 (55%), Positives = 298/396 (75%), Gaps = 10/396 (2%)
Query: 64 RAGAG---ALLRLPSE---RLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRF 117
R G G +L R+P R+DFS+A ALN F TR++E+ E+ ELNDRFA++IEKVRF
Sbjct: 30 RLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRF 89
Query: 118 LEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLA 177
LEQQN AL EL+Q R +EP + + Q ELRELR L+ L R++VERD LA+DLA
Sbjct: 90 LEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLA 149
Query: 178 ALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 237
++Q+L++ET R +AE+NL +R++ D+ATL+RL+LERKIESL +EI FL+K+HEEE+R
Sbjct: 150 TVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVR 209
Query: 238 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDA 297
+LQ + QQV VE++ KP+LTAAL++IR QYE++A+ N+ EAEEWY+SK+ADL+DA
Sbjct: 210 ELQEQLARQQVH-VELDVA-KPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDA 267
Query: 298 ANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAG 357
A RN E LRQAK E N+ RRQ+QSLTC+++ LRGTNE+L RQ+RE EE+ EA YQ
Sbjct: 268 AARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEA 327
Query: 358 AARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASL 417
ARLEEE + LK+EMARHL+EYQ+LLNVK+ALDIEIATYRKLLEGEE+RI++PV +F++L
Sbjct: 328 LARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
Query: 418 NIK--TTVPEVEPPQDSHSRKTVLIKTIETRNGEVV 451
I+ + + E + + K++ I+ I + ++V
Sbjct: 388 QIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIV 423
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 377 bits (969), Expect = e-105
Identities = 217/430 (50%), Positives = 292/430 (67%), Gaps = 22/430 (5%)
Query: 13 SSTSYRRTFGPPPSLSP------GAFSYSSSSRFSSSRLLGSASPSSSVRLG---SFRSP 63
SS+SYR+ FG LS GA + S S S S + SA+ SS+ LG ++R P
Sbjct: 11 SSSSYRKVFGDGSRLSARLSGAGGAGGFRSQS-LSRSNVASSAACSSASSLGLGLAYRRP 69
Query: 64 RAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNA 123
A G LD S A A E+ R+NEK++LQ LNDRFA FIEKV LE QN
Sbjct: 70 PASDG---------LDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120
Query: 124 ALRGELSQARGQ--EPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQ 181
AL EL+ R + EP+R +L Q+ELR+LR +LE R + +ERDGLAE++ L+
Sbjct: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
Query: 182 RLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQV 241
R EEE+R RE AE L ++DVD ATL+RL+LE+K+ESL+DE+ F++++H+EE+ +L
Sbjct: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
Query: 242 SVESQQVQQVEVEATV-KPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANR 300
++++ EV+ TV KP+LT+ALR+IRAQYES+AAKNLQ AEEWYKSK+A+L++ A R
Sbjct: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
Query: 301 NHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAAR 360
+ EA+R +++E++E RRQ+Q+ T E++GLRG NE+L RQ+ ELEE+ + E GYQ +
Sbjct: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
Query: 361 LEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIK 420
LE +LR K EMARHLREYQ+LLNVKMALDIEIA YRKLLEGEE+R S S + LN
Sbjct: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPL 420
Query: 421 TTVPEVEPPQ 430
+ PP+
Sbjct: 421 PNPSYLLPPR 430
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 337 bits (865), Expect = 1e-92
Identities = 197/401 (49%), Positives = 273/401 (68%), Gaps = 12/401 (2%)
Query: 12 FSSTSYRRTFGPPPSLSPGAF-SYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGAL 70
+ STSY+R + P + + S S++R + S S S SVR RS + +G+L
Sbjct: 9 YYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVR----RSYSSSSGSL 64
Query: 71 LRLPS-ERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGEL 129
+ PS E LD S A++ + + R+ EK +LQ+LNDRFA+FIE+V LEQQN L EL
Sbjct: 65 M--PSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAEL 122
Query: 130 SQARGQ--EPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEET 187
R + EP+R L +QE+R+LR E E+ +Q ER+GL E L L+ R EEE
Sbjct: 123 LVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEV 182
Query: 188 RKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQ 247
REDAE L+ RK D+A L+R ELE++I+SLMDEI FLKK+HEEE+ +LQ ++ Q
Sbjct: 183 LSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQ 242
Query: 248 VQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQ 307
+ VE++ T KP+L+AAL+DIRAQYE +AAKN+Q AEEW+KS++ L+++A +N +A+R
Sbjct: 243 IS-VEMDVT-KPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300
Query: 308 AKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQ 367
AK E++ESRR +++ T E++ RG NEAL +QL+ELE++ + Q +LE ELR
Sbjct: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360
Query: 368 LKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRIS 408
K EMAR+L+EYQ+LLNVKMALDIEIA YRKLLEGEE+R+S
Sbjct: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLS 401
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 325 bits (832), Expect = 7e-89
Identities = 196/472 (41%), Positives = 297/472 (62%), Gaps = 32/472 (6%)
Query: 15 TSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPR-AGAGALLRL 73
++YRR S S + S SS R S S GS S SS S +PR A + A+L
Sbjct: 12 SAYRRVTETRSSFSRVSGSPSSGFR-SQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSS 70
Query: 74 PSERLDFSMAEAL-------NQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALR 126
LDFS + +L ++ +RSNEK++LQ LNDRFA +IEKV +LEQQN +
Sbjct: 71 AESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIE 130
Query: 127 GELSQARGQEPARAD--QLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLE 184
E+ R ++ + A QE+RELR LE++ E+ +VQ++ D L ED+ LK+R E
Sbjct: 131 AEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFE 190
Query: 185 EETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVE 244
EE R R+D E + RKD+++A+L ++EL++K++SL DE+ FL+ HEEE+ DL ++
Sbjct: 191 EEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQ 250
Query: 245 SQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEA 304
+ + VE + +K +++ AL++IR+Q ES + +N+ +AEEW+K +YA L++AA +N EA
Sbjct: 251 ASHIT-VERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEA 309
Query: 305 LRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEE 364
+R AK+E+ E RRQ+QS + E++ +RGT E+L RQL ++EE+ + YQ +LE E
Sbjct: 310 IRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENE 369
Query: 365 LRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISV-------PVHSF--- 414
LR K EMARHLREYQ+LLNVKMALDIEIA YRKLLEGEE+R S P+++
Sbjct: 370 LRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPP 429
Query: 415 ASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQ-KEQRSELDKS 465
+++ K P+VE P+ K V E++ E++ ++++SE++++
Sbjct: 430 ITISSKIQKPKVEAPKLKVQHKFV---------EEIIEETKVEDEKSEMEEA 472
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 266 bits (680), Expect = 3e-71
Identities = 155/390 (39%), Positives = 245/390 (62%), Gaps = 19/390 (4%)
Query: 91 LATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQEL 148
+AT +EK++LQ LNDRFA +I+KVR LE N +L GE + R Q+ R+ +L ++E+
Sbjct: 91 VATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREV 150
Query: 149 RELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDAT 208
RE+R + LG R ++++E++ L ED+A ++QRL++E R+RE+AE + +A
Sbjct: 151 REMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAE 210
Query: 209 LSRLELERKIESLMDEIEFLKKLHEEELRDL----QVSVESQQVQQVEVEATVKPELTAA 264
+R++L++K ++L +E +L++ H+EE+ +L Q S +Q Q E +K ++T+A
Sbjct: 211 AARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSA 270
Query: 265 LRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTC 324
LR+IRAQ E A ++ ++EEW++ + LS+AA N +A+R A++E+ E RRQ+Q+ T
Sbjct: 271 LREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTT 330
Query: 325 EVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLN 384
E++ L+ T ++L RQ ELE++ + YQ +L+ ELR K EMA LREYQ+LLN
Sbjct: 331 ELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLN 390
Query: 385 VKMALDIEIATYRKLLEGEESRI-----------SVPVHSFASLNIKTTVPEVEPPQDSH 433
VKMALDIEIA YRKLLEGEE RI +P S +IK E +
Sbjct: 391 VKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKS 450
Query: 434 SRKTVLI--KTIETRNGEVVTESQKEQRSE 461
++TV++ +T ET+ E VTE ++++ E
Sbjct: 451 EKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 265 bits (678), Expect = 5e-71
Identities = 173/484 (35%), Positives = 273/484 (56%), Gaps = 56/484 (11%)
Query: 6 SGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRA 65
SG RA FSS SY T GP +S +FS SS F LG +
Sbjct: 15 SGPRA-FSSRSY--TSGPGSRISSSSFSRVGSSNFRGG-------------LGGGYGGAS 58
Query: 66 GAGALLRLP-SERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAA 124
G G + + ++ L + ++ A R+ EK++++ LN++FA+FI+KVRFLEQQN
Sbjct: 59 GMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKM 118
Query: 125 LRGELSQARGQEPARA--DQLCQQELRELRRELELLGRERDRVQVE---RDGLAEDLAAL 179
L + S + Q+ AR+ D + + + LRR+LE LG+E+ +++ E GL ED
Sbjct: 119 LETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDF--- 175
Query: 180 KQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDL 239
K + E+E KR + E+ VL +KDVD+A ++++ELE ++E L DEI FL++L+EEE+R+L
Sbjct: 176 KNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIREL 235
Query: 240 QVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAAN 299
Q + V + ++ + ++ + + +++AQYE IA ++ EAE Y+ KY +L A
Sbjct: 236 QSQISDTSVV-LSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAG 294
Query: 300 RNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAA 359
++ + LR+ K E++E R I L E++GL+G +L + + E++ L A +
Sbjct: 295 KHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLS 354
Query: 360 RLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNI 419
LE L++ K++MAR LREYQEL+NVK+ALDIEIATYRKLLEGEESR+ + + S++
Sbjct: 355 ELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNM-SIHT 413
Query: 420 KTTVPEVEPPQDSH-----------------------------SRKTVLIKTIETRNGEV 450
KTT ++ S + V++K IETR+G++
Sbjct: 414 KTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKL 473
Query: 451 VTES 454
V+ES
Sbjct: 474 VSES 477
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 233 bits (594), Expect = 3e-61
Identities = 128/319 (40%), Positives = 200/319 (62%), Gaps = 5/319 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAAL--RGELSQARGQEPARA--DQLCQQELR 149
R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G + R + L +Q +
Sbjct: 165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 224
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
LRR+L+ + ER R+ E + + + K + E+E KR AE+ V+ +KDVD A +
Sbjct: 225 NLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYM 284
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++ELE K+++LMDEI F+K + EL +Q V V + ++ +L + + +++
Sbjct: 285 NKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVV-LSMDNNRNLDLDSIIAEVK 343
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE WY++KY +L A R+ + LR K E++E R IQ L E+D +
Sbjct: 344 AQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNV 403
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ L + + E++ L + A LEE L++ K++MAR LREYQEL+N K+AL
Sbjct: 404 KKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLAL 463
Query: 390 DIEIATYRKLLEGEESRIS 408
D+EIATYRKLLEGEE R+S
Sbjct: 464 DVEIATYRKLLEGEECRLS 482
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 232 bits (592), Expect = 5e-61
Identities = 132/333 (39%), Positives = 206/333 (61%), Gaps = 5/333 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAALRGE--LSQARGQEPARA--DQLCQQELR 149
R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G R + L
Sbjct: 146 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTS 205
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
ELRR+LE + ER R++ E + + + K R E+E KR AE+ V +KDVD A +
Sbjct: 206 ELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYM 265
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++ELE K++SL +EI F+ + + EL LQ V V + ++ +L + + +++
Sbjct: 266 NKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVV-LSMDNNRNLDLDSIIAEVK 324
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE WY++KY +L A R+ + LR KQE++E R IQ L E+D +
Sbjct: 325 AQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSV 384
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ +L + + E++ L +A LEE L++ K++MAR LREYQEL+N+K+AL
Sbjct: 385 KKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLAL 444
Query: 390 DIEIATYRKLLEGEESRISVPVHSFASLNIKTT 422
D+EIATYRKLLEGEE R+S S ++++ T+
Sbjct: 445 DVEIATYRKLLEGEECRLSGEGVSPVNISVVTS 477
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 226 bits (575), Expect = 4e-59
Identities = 141/400 (35%), Positives = 225/400 (56%), Gaps = 29/400 (7%)
Query: 37 SSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEA----------- 85
SS +SR + + VRL S R G+ +L L + R ++ A
Sbjct: 6 SSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIRE 65
Query: 86 --LNQEFLA------------TRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQ 131
+NQ LA R E ++++ LN++FA+FI+KVRFLEQQN L + +
Sbjct: 66 VTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTL 125
Query: 132 ARGQEPARADQL---CQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETR 188
+ Q+ A++ +L + ++ LR +LE L + R++ E + + + K + E+E
Sbjct: 126 LQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEIN 185
Query: 189 KREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQV 248
R AE+ V+ +KDVD A +S++ELE K+++L DEI FL+ L+E EL +LQ + V
Sbjct: 186 HRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSV 245
Query: 249 QQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQA 308
+ ++ + +L + +++AQYE +A + EAE WY++K+ L A ++ + LR
Sbjct: 246 V-LSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNT 304
Query: 309 KQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQL 368
+ E++E R IQ L E+D ++ L + E EE+ L +A LE L++
Sbjct: 305 RNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRG 364
Query: 369 KEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRIS 408
K++MAR LREYQEL++VK+ALDIEIATYRKLLEGEESR++
Sbjct: 365 KQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLA 404
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 223 bits (567), Expect = 4e-58
Identities = 123/319 (38%), Positives = 201/319 (63%), Gaps = 5/319 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAAL--RGELSQARGQEPARA--DQLCQQELR 149
R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G + R + L +Q +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
LRR+L+ + ER R+ E + + + LK + E+E KR AE+ V +KDVD A +
Sbjct: 220 NLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++EL+ K ++L DEI FL+ L++ EL +Q + V + ++ +L + + +++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV-VLSMDNNRNLDLDSIIAEVK 338
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE WY++KY +L A R+ + LR KQE+ E R IQ L E+D +
Sbjct: 339 AQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHV 398
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ +L + + E++ + + LE+ L++ K+++AR L+EYQEL+NVK+AL
Sbjct: 399 KKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLAL 458
Query: 390 DIEIATYRKLLEGEESRIS 408
D+EIATYRKLLEGEE R++
Sbjct: 459 DVEIATYRKLLEGEECRLN 477
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 222 bits (566), Expect = 5e-58
Identities = 123/319 (38%), Positives = 200/319 (62%), Gaps = 5/319 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAALRGE--LSQARGQEPARA--DQLCQQELR 149
R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G + R + L +Q +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
LRR+L+ + ER R+ E G+ + + K + E+E KR AE+ V +KDVD A +
Sbjct: 220 NLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++EL+ K ++L DEI FL+ L++ EL +Q + V + ++ +L + + +++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV-VLSMDNNRNLDLDSIIAEVK 338
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE WY++KY +L A R+ + LR KQE+ E R IQ L E+D +
Sbjct: 339 AQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHV 398
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ L + + E++ + + LE+ L++ K+++AR L+EYQEL+NVK+AL
Sbjct: 399 KKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLAL 458
Query: 390 DIEIATYRKLLEGEESRIS 408
D+EIATYRKLLEGEE R++
Sbjct: 459 DVEIATYRKLLEGEECRLN 477
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 221 bits (563), Expect = 1e-57
Identities = 123/319 (38%), Positives = 200/319 (62%), Gaps = 5/319 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAAL--RGELSQARGQEPARA--DQLCQQELR 149
R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G + R + L +Q +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
LRR+L+ + ER R+ E + + + LK + E+E KR AE+ V +KDVD A +
Sbjct: 220 NLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++EL+ K ++L DEI FL+ L++ EL +Q + V + ++ +L + + +++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV-VLSMDNNRNLDLDSIIAEVK 338
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE WY++KY +L A R+ + LR KQE+ E R IQ L E+D +
Sbjct: 339 AQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHV 398
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ L + + E++ + + LE+ L++ K+++AR L+EYQEL+NVK+AL
Sbjct: 399 KKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLAL 458
Query: 390 DIEIATYRKLLEGEESRIS 408
D+EIATYRKLLEGEE R++
Sbjct: 459 DVEIATYRKLLEGEECRLN 477
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 221 bits (562), Expect = 1e-57
Identities = 133/367 (36%), Positives = 215/367 (58%), Gaps = 12/367 (3%)
Query: 47 GSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRSNEKQELQ 102
G P R+G P A + + + ++ S+ LN E + +EK++++
Sbjct: 116 GFGGPGFGYRVGGVGVPAAPS-----ITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIK 170
Query: 103 ELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRRELELLGR 160
LN++FA+FI+KVRFLEQQN L + S + Q+ R+ + L + + LRR+LE+L
Sbjct: 171 TLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVS 230
Query: 161 ERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIES 220
++ R+Q ER+ L + L K++ EEE R +AE+ V +KDVD A +++ +LE +++
Sbjct: 231 DQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNKSDLEANVDT 290
Query: 221 LMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNL 280
L EI+FLK L+ EE++ LQ + V V+++ + L + +++AQYE +A ++
Sbjct: 291 LTQEIDFLKTLYMEEIQLLQSHISETSVI-VKMDNSRDLNLDGIIAEVKAQYEEVARRSR 349
Query: 281 QEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQL 340
+AE WY++KY ++ A ++ + LR + E+NE R IQ L E++ + L +
Sbjct: 350 ADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAV 409
Query: 341 RELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLL 400
E E+Q + A LE L+Q K++MAR L EYQEL+N K+ LDIEIATYR+LL
Sbjct: 410 AEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLL 469
Query: 401 EGEESRI 407
EGEESR+
Sbjct: 470 EGEESRL 476
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 219 bits (559), Expect = 3e-57
Identities = 126/338 (37%), Positives = 205/338 (60%), Gaps = 5/338 (1%)
Query: 86 LNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQ--- 142
++ E R+ E+++++ LN++FA+FI+KV+FLEQQN L + + + Q + +
Sbjct: 200 IDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLE 259
Query: 143 -LCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFR 201
L + L LR++L+ LG ++ R+Q E + + + K + EEE KR AE++ V+ +
Sbjct: 260 PLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLK 319
Query: 202 KDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPEL 261
KDVD A L+++ELE K++SL DEI FLK L++ EL +Q V V + ++ +L
Sbjct: 320 KDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSV-VLSMDNNRNLDL 378
Query: 262 TAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQS 321
+ + ++RAQYE IA ++ EAE Y++K L + +++ + L+ K E+ E R IQ
Sbjct: 379 DSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQR 438
Query: 322 LTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQE 381
L E++ ++ + L + + E++ + LE L+Q KEE+AR LREYQE
Sbjct: 439 LRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQE 498
Query: 382 LLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNI 419
L++VK+ALDIEIATYRKLLEGEE R+S S S+++
Sbjct: 499 LMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISV 536
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 218 bits (555), Expect = 9e-57
Identities = 136/380 (35%), Positives = 212/380 (55%), Gaps = 7/380 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 45 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 104
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + + LRR
Sbjct: 105 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR 164
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 165 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD 224
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+R LQ + V V+++ + + + +I+AQY+
Sbjct: 225 LEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVV-VKLDNSRDLNMDCIIAEIKAQYD 283
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
I ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 284 DIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 343
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 344 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 403
Query: 394 ATYRKLLEGEESRISVPVHS 413
ATYR+LLEGEE R+ V S
Sbjct: 404 ATYRRLLEGEEQRLCEGVGS 423
>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 486
Score = 218 bits (555), Expect = 9e-57
Identities = 136/380 (35%), Positives = 212/380 (55%), Gaps = 7/380 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 45 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 104
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + + LRR
Sbjct: 105 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR 164
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 165 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD 224
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+R LQ + V V+++ + + + +I+AQY+
Sbjct: 225 LEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVV-VKLDNSRDLNMDCIIAEIKAQYD 283
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
I ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 284 DIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 343
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 344 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 403
Query: 394 ATYRKLLEGEESRISVPVHS 413
ATYR+LLEGEE R+ V S
Sbjct: 404 ATYRRLLEGEEQRLCEGVGS 423
>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
sapiens]
Length = 486
Score = 218 bits (555), Expect = 9e-57
Identities = 136/380 (35%), Positives = 212/380 (55%), Gaps = 7/380 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 45 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 104
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + + LRR
Sbjct: 105 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR 164
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 165 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD 224
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+R LQ + V V+++ + + + +I+AQY+
Sbjct: 225 LEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVV-VKLDNSRDLNMDCIIAEIKAQYD 283
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
I ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 284 DIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 343
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 344 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 403
Query: 394 ATYRKLLEGEESRISVPVHS 413
ATYR+LLEGEE R+ V S
Sbjct: 404 ATYRRLLEGEEQRLCEGVGS 423
>gi|14318422 keratin 86 [Homo sapiens]
Length = 486
Score = 218 bits (555), Expect = 9e-57
Identities = 136/380 (35%), Positives = 212/380 (55%), Gaps = 7/380 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 45 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 104
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + + LRR
Sbjct: 105 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR 164
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 165 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD 224
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+R LQ + V V+++ + + + +I+AQY+
Sbjct: 225 LEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVV-VKLDNSRDLNMDCIIAEIKAQYD 283
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
I ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 284 DIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 343
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 344 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 403
Query: 394 ATYRKLLEGEESRISVPVHS 413
ATYR+LLEGEE R+ V S
Sbjct: 404 ATYRRLLEGEEQRLCEGVGS 423
>gi|169790841 keratin 83 [Homo sapiens]
Length = 493
Score = 218 bits (554), Expect = 1e-56
Identities = 135/374 (36%), Positives = 210/374 (56%), Gaps = 7/374 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 50 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 109
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + LRR
Sbjct: 110 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGYIETLRR 169
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 170 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSD 229
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+R LQ + V V+++ + + + +I+AQY+
Sbjct: 230 LEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVV-VKLDNSRDLNMDCIVAEIKAQYD 288
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
IA ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 289 DIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 348
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 349 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 408
Query: 394 ATYRKLLEGEESRI 407
ATYR+LLEGEE R+
Sbjct: 409 ATYRRLLEGEEQRL 422
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 216 bits (551), Expect = 3e-56
Identities = 151/422 (35%), Positives = 236/422 (55%), Gaps = 11/422 (2%)
Query: 7 GLRAGFSSTSYRRTFGPPPSLSPGAFS---YSSSSRFSSSRLLGSA-SPSSSVRLGSFRS 62
GL GFSS S + G S+S S ++ F R G A S SV LGS
Sbjct: 38 GLSGGFSSRSLY-SLGGARSISFNVASGSGWAGGYGFGRGRASGFAGSMFGSVALGSVCP 96
Query: 63 PRAGAGALLRLP-SERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQ 121
G + ++ ++ L + L+ E R+ E+++++ LN++FA+FI+KVRFLEQQ
Sbjct: 97 SLCPPGGIHQVTINKSLLAPLNVELDPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQ 156
Query: 122 NAAL--RGELSQARGQEPAR--ADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLA 177
N L + EL Q + + + + + LR++LE L +R R+ E + E +
Sbjct: 157 NQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRSVREVVE 216
Query: 178 ALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 237
K+R EEE KR AE+ V+ +KDVD A S++EL+ K+++L EI+F K L+E E
Sbjct: 217 DYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETA 276
Query: 238 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDA 297
+Q + + + ++ +L + + ++RAQYE IA K+ EAE Y++K+ +L A
Sbjct: 277 QIQSHISDTSII-LSMDNNRNLDLDSIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLA 335
Query: 298 ANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAG 357
A R+ + L+ K E++E R IQ L E++ ++ L + + E++ +A
Sbjct: 336 AGRHGDDLKHTKNEISELTRLIQRLRSEIESVKKQCANLETAIADAEQRGDCALKDARAK 395
Query: 358 AARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASL 417
LE L+Q KEE+AR LREYQELL+VK++LDIEIATYRKLLEGEE R+S + S+
Sbjct: 396 LDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSI 455
Query: 418 NI 419
++
Sbjct: 456 SV 457
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 216 bits (549), Expect = 5e-56
Identities = 137/401 (34%), Positives = 214/401 (53%), Gaps = 18/401 (4%)
Query: 30 GAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGALLR-----------LPSERL 78
G Y + F S L S + +G FR+ G R + + +
Sbjct: 41 GVSCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSV 100
Query: 79 DFSMAEALNQEF----LATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARG 134
+ S+ LN E + EK++++ LN RFA FI+KVRFLEQQN L + +
Sbjct: 101 NESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQN 160
Query: 135 QE--PARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKRED 192
Q + + L + LRRE E + + R+ E + + E L K++ EEE R
Sbjct: 161 QRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRAT 220
Query: 193 AEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVE 252
AE+ V+ +KDVD A L + +LE +E+L++E FL++L+EEE+R LQ + V V+
Sbjct: 221 AENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVI-VK 279
Query: 253 VEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEM 312
++ + + + +I+AQY+ +A+++ EAE WY+SK ++ R+ E LR+ K+E+
Sbjct: 280 MDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEI 339
Query: 313 NESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEM 372
NE R IQ LT E++ + L + E E+Q + A LE L++ K++M
Sbjct: 340 NELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDM 399
Query: 373 ARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHS 413
A L+EYQE++N K+ LDIEIATYR+LLEGEE R+ V S
Sbjct: 400 ACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGS 440
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 215 bits (547), Expect = 8e-56
Identities = 122/332 (36%), Positives = 200/332 (60%), Gaps = 7/332 (2%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAAL--RGELSQARGQEPARA----DQLCQQE 147
++ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +G + L +
Sbjct: 195 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENH 254
Query: 148 LRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDA 207
+ LR L+ + ER R+ E + + + K++ E+E KR AE+ V +KDVD A
Sbjct: 255 INYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSA 314
Query: 208 TLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRD 267
++++EL+ K+++L+DEI+FL+ L++ EL +Q + V + ++ +L + + +
Sbjct: 315 YMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV-LSMDNNRSLDLDSIIAE 373
Query: 268 IRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVD 327
+RAQYE IA ++ EAE Y++K +L A R+ + LR K E+ E R IQ L E++
Sbjct: 374 VRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIE 433
Query: 328 GLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKM 387
G++ N L + E E+ + A L+ L+Q K+++AR LR+YQEL+NVK+
Sbjct: 434 GVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKL 493
Query: 388 ALDIEIATYRKLLEGEESRISVPVHSFASLNI 419
ALD+EIATYRKLLEGEE R+S S S+++
Sbjct: 494 ALDVEIATYRKLLEGEEYRMSGECPSAVSISV 525
>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
Length = 505
Score = 215 bits (547), Expect = 8e-56
Identities = 133/374 (35%), Positives = 209/374 (55%), Gaps = 7/374 (1%)
Query: 40 FSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEF----LATRS 95
F S + G S R +RS + + + ++ S+ LN E +
Sbjct: 45 FGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ 104
Query: 96 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQELRELRR 153
EK++++ LN RFA FI+KVRFLEQQN L +L + +E ++ + L + + LRR
Sbjct: 105 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR 164
Query: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLE 213
E E + + R+ E + + E L K++ EEE R AE+ V +KDVD A L + +
Sbjct: 165 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD 224
Query: 214 LERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE 273
LE +E+L+ EI+FL++L+EEE+ LQ + V V+++ + + + +I+AQY+
Sbjct: 225 LEANVEALIQEIDFLRRLYEEEILILQSHISDTSVV-VKLDNSRDLNMDCIIAEIKAQYD 283
Query: 274 SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTN 333
I ++ EAE WY+SK ++ R+ E LR+ K+E+NE R IQ LT EV+ + N
Sbjct: 284 DIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQN 343
Query: 334 EALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEI 393
L + + E+Q + A LE L++ K++MA +REYQE++N K+ LDIEI
Sbjct: 344 SKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEI 403
Query: 394 ATYRKLLEGEESRI 407
ATYR+LLEGEE R+
Sbjct: 404 ATYRRLLEGEEQRL 417
>gi|32567786 keratin 6L [Homo sapiens]
Length = 535
Score = 211 bits (538), Expect = 9e-55
Identities = 126/340 (37%), Positives = 198/340 (58%), Gaps = 7/340 (2%)
Query: 86 LNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGE--LSQARGQEPA----R 139
++ E R+ E+++++ LN++FA+FI+KVRFLEQQN L + L Q +GQ
Sbjct: 131 IDPEIQRVRTQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGQNLGVTRNN 190
Query: 140 ADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVL 199
+ L + L +R L+ L ER R+ E + + + K + E+E K AE+ V+
Sbjct: 191 LEPLFEAYLGSMRSTLDRLQSERGRLDSELRNVQDLVEDFKNKYEDEINKHTAAENEFVV 250
Query: 200 FRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKP 259
+KDVD A + R++L K+ +L EI+FL++L+E EL +Q V + V + ++
Sbjct: 251 LKKDVDAAYMGRMDLHGKVGTLTQEIDFLQQLYEMELSQVQTHVSNTNVV-LSMDNNRNL 309
Query: 260 ELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQI 319
+L + + +++AQYE IA ++ EAE WY++KY +L A ++ + LR K E+ E R I
Sbjct: 310 DLDSIIAEVKAQYELIAQRSRAEAEAWYQTKYEELQVTAGKHGDNLRDTKNEIAELTRTI 369
Query: 320 QSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREY 379
Q L E D + + L + E E++ L Q L+ L Q KE++ R LR+Y
Sbjct: 370 QRLQGEADAAKKQCQQLQTAIAEAEQRGELALKDAQKKLGDLDVALHQAKEDLTRLLRDY 429
Query: 380 QELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNI 419
QEL+NVK+ALD+EIATYRKLLE EESR+S S S+++
Sbjct: 430 QELMNVKLALDVEIATYRKLLESEESRMSGECPSAVSISV 469
>gi|15618995 keratin 71 [Homo sapiens]
Length = 523
Score = 209 bits (532), Expect = 4e-54
Identities = 148/420 (35%), Positives = 231/420 (55%), Gaps = 9/420 (2%)
Query: 7 GLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSR-FSSSRLLGSA-SPSSSVRLGSFRSPR 64
GL GF S S + G SL+ + S S F R G A S SV LG
Sbjct: 38 GLSGGFGSRSLY-SLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTV 96
Query: 65 AGAGALLRLP-SERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNA 123
G + ++ +E L + L+ E R+ E+++++ LN++FA+FI+KVRFLEQQN
Sbjct: 97 CPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQ 156
Query: 124 AL--RGELSQARGQEPAR--ADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAAL 179
L + EL Q + + + + + LR++LE L +R R+ E + + +
Sbjct: 157 VLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDY 216
Query: 180 KQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDL 239
K+R EEE KR AE+ VL +KDVD A +++EL+ K+ES+ EI+F + L E E+ +
Sbjct: 217 KKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQI 276
Query: 240 QVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAAN 299
Q + V + ++ +L + + ++R QYE IA K+ EAE Y++K+ +L AA
Sbjct: 277 QSHISDMSVI-LSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAG 335
Query: 300 RNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAA 359
R+ + L+ K E++E R IQ + E++ ++ L + + E++ +A
Sbjct: 336 RHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLD 395
Query: 360 RLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNI 419
LE L Q KEE+AR LREYQEL+++K+ALD+EIATYRKLLE EE R+S S S++I
Sbjct: 396 ELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISI 455
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 209 bits (532), Expect = 4e-54
Identities = 121/334 (36%), Positives = 200/334 (59%), Gaps = 5/334 (1%)
Query: 94 RSNEKQELQELNDRFANFIEKVRFLEQQNAAL--RGEL--SQARGQEPARADQLCQQELR 149
++ E+++++ LN++FA+FI+KVRFLEQQN L + EL Q G P+ + + +
Sbjct: 180 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYIS 239
Query: 150 ELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATL 209
L ++L+ L ER ++ E + + + K++ E+E KR AE+ V +KDVD A +
Sbjct: 240 FLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFM 299
Query: 210 SRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIR 269
+++EL+ K++SL DE+ FL+ L+E EL +Q V + ++ +L + + ++R
Sbjct: 300 NKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVV-LSMDNNRCLDLGSIIAEVR 358
Query: 270 AQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329
AQYE IA ++ EAE Y++K +L A R+ + LR K E+ E R IQ L E++ +
Sbjct: 359 AQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENV 418
Query: 330 RGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL 389
+ N L + E E++ + A L+ L++ K+++AR LR+YQEL+NVK+AL
Sbjct: 419 KKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLAL 478
Query: 390 DIEIATYRKLLEGEESRISVPVHSFASLNIKTTV 423
D+EIATYRKLLEGEE R+S S +++ + V
Sbjct: 479 DVEIATYRKLLEGEECRMSGECQSAVCISVVSNV 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,389,990
Number of Sequences: 37866
Number of extensions: 758705
Number of successful extensions: 9571
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 842
Number of HSP's that attempted gapping in prelim test: 4778
Number of HSP's gapped (non-prelim): 3169
length of query: 470
length of database: 18,247,518
effective HSP length: 106
effective length of query: 364
effective length of database: 14,233,722
effective search space: 5181074808
effective search space used: 5181074808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.