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Search of human proteins with 21040366
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21040366 beta-site APP-cleaving enzyme 1 isoform B
preproprotein [Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 978 0.0
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 964 0.0
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 875 0.0
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 870 0.0
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 405 e-113
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 326 2e-89
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 306 3e-83
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 94 4e-19
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 90 4e-18
gi|119372302 pepsinogen 4, group I [Homo sapiens] 89 7e-18
gi|119372298 pepsinogen 3, group I [Homo sapiens] 89 7e-18
gi|23943854 pepsinogen 5, group I [Homo sapiens] 89 7e-18
gi|4503143 cathepsin D preproprotein [Homo sapiens] 87 3e-17
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 78 2e-14
gi|4506475 renin preproprotein [Homo sapiens] 74 3e-13
gi|4758754 napsin A preproprotein [Homo sapiens] 61 3e-09
gi|195972905 zinc finger protein 385A isoform b [Homo sapiens] 36 0.087
gi|110349761 NSL1, MIND kinetochore complex component isoform 2 ... 33 0.43
gi|110349759 NSL1, MIND kinetochore complex component isoform 1 ... 33 0.43
gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 ... 31 2.2
gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3... 31 2.8
gi|195972903 zinc finger protein 385A isoform a [Homo sapiens] 30 4.8
gi|24308079 zinc finger protein 385A isoform c [Homo sapiens] 30 4.8
gi|44890065 hypothetical protein LOC6936 [Homo sapiens] 30 6.3
gi|21361127 potassium inwardly-rectifying channel J15 [Homo sapi... 30 6.3
gi|25777640 potassium inwardly-rectifying channel J15 [Homo sapi... 30 6.3
gi|25777638 potassium inwardly-rectifying channel J15 [Homo sapi... 30 6.3
gi|77917617 hypothetical protein LOC54463 isoform 1 [Homo sapiens] 30 6.3
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 29 8.2
gi|40255133 hypothetical protein LOC222256 [Homo sapiens] 29 8.2
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 978 bits (2529), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
Query: 181 GLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 240
GLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV
Sbjct: 181 GLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 240
Query: 241 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 300
RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG
Sbjct: 241 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 300
Query: 301 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 360
EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI
Sbjct: 301 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 360
Query: 361 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 420
SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY
Sbjct: 361 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 420
Query: 421 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 476
NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Sbjct: 421 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 476
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 964 bits (2493), Expect = 0.0
Identities = 476/501 (95%), Positives = 476/501 (95%), Gaps = 25/501 (4%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
Query: 181 GLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGGSMIIGGI 215
GLAYAEIAR LCGAGFPLNQSEVLASVGGSMIIGGI
Sbjct: 181 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240
Query: 216 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 275
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
Sbjct: 241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 300
Query: 276 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 335
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
Sbjct: 301 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 360
Query: 336 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 395
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
Sbjct: 361 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 420
Query: 396 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 455
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
Sbjct: 421 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 480
Query: 456 RCLRCLRQQHDDFADDISLLK 476
RCLRCLRQQHDDFADDISLLK
Sbjct: 481 RCLRCLRQQHDDFADDISLLK 501
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 875 bits (2261), Expect = 0.0
Identities = 434/476 (91%), Positives = 444/476 (93%), Gaps = 19/476 (3%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDL P+ ++ ++ + ++ +
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDL------PDDSLEPFFDSLVKQ-------THVPNLF 167
Query: 181 GLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 240
L +LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV
Sbjct: 168 SL------QLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 221
Query: 241 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 300
RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG
Sbjct: 222 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 281
Query: 301 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 360
EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI
Sbjct: 282 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 341
Query: 361 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 420
SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY
Sbjct: 342 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 401
Query: 421 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 476
NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Sbjct: 402 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 457
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 870 bits (2248), Expect = 0.0
Identities = 432/476 (90%), Positives = 432/476 (90%), Gaps = 44/476 (9%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDL----------------------------------- 145
Query: 181 GLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 240
LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV
Sbjct: 146 ---------LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIV 196
Query: 241 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 300
RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG
Sbjct: 197 RVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLG 256
Query: 301 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 360
EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI
Sbjct: 257 EQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAI 316
Query: 361 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 420
SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY
Sbjct: 317 SQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY 376
Query: 421 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 476
NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Sbjct: 377 NIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 432
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 405 bits (1040), Expect = e-113
Identities = 206/448 (45%), Positives = 282/448 (62%), Gaps = 32/448 (7%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGG 208
W GILGLAYA +A+ +CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 209 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 268
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 269 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 328
LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E +
Sbjct: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367
Query: 329 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 388
++SFRITILPQ Y++P+ + +CY+F IS S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 368 SRSFRITILPQLYIQPMMGAGLNY-ECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRV 426
Query: 389 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 447
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 427 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 486
Query: 448 LCLMVCQWRCLRCLRQQHDDFADDISLL 475
+ L++ +RC R R + + +D S L
Sbjct: 487 IVLLLLPFRCQR--RPRDPEVVNDESSL 512
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 326 bits (836), Expect = 2e-89
Identities = 160/312 (51%), Positives = 207/312 (66%), Gaps = 28/312 (8%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGG 208
W GILGLAYA +A+ +CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 209 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 268
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 269 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 328
LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E +
Sbjct: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367
Query: 329 NQSFRITILPQQ 340
++SFRITILPQ+
Sbjct: 368 SRSFRITILPQK 379
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 306 bits (784), Expect = 3e-83
Identities = 175/448 (39%), Positives = 242/448 (54%), Gaps = 82/448 (18%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGG 208
W GILGLAYA +A+ +CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 209 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 268
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 269 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 328
LRLP+KVF+A V+++ AS P G C++ G +P
Sbjct: 308 LLRLPQKVFDAVVEAVARASLLYIQP-MMGAGLNYECYRFGISP---------------- 350
Query: 329 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 388
S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 351 ----------------------------------STNALVIGATVMEGFYVIFDRAQKRV 376
Query: 389 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 447
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 377 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 436
Query: 448 LCLMVCQWRCLRCLRQQHDDFADDISLL 475
+ L++ +RC R R + + +D S L
Sbjct: 437 IVLLLLPFRCQR--RPRDPEVVNDESSL 462
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 93.6 bits (231), Expect = 4e-19
Identities = 89/344 (25%), Positives = 151/344 (43%), Gaps = 56/344 (16%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARL 190
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLA-- 193
Query: 191 CGAGFPLNQSEVLASV------------------GGSMIIGGIDHSLYTGSLWYTPIRRE 232
G P+ + + ++ G +I GG DHS ++GSL + P+ ++
Sbjct: 194 VGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQ 253
Query: 233 WYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEK 292
Y+++ + +++ G M C E ++IVD+GT+ + P + +I AA
Sbjct: 254 AYWQIALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP---- 305
Query: 293 FPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
DG + E N+ P ++ + G T+ P Y + D
Sbjct: 306 -VDGEYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TLLDFVDGM 348
Query: 353 DDC---YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 391
C ++ G ++G V + FY VFDR R+G A
Sbjct: 349 QFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 90.1 bits (222), Expect = 4e-18
Identities = 85/344 (24%), Positives = 150/344 (43%), Gaps = 52/344 (15%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY + +
Sbjct: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNW-----EGILGLAYA 185
Y G G G D +++ ++ V ++E++ G+N+ +GI+GLAY
Sbjct: 133 QYGSGSLTGFFGYDTLTVQ---SIQVPNQEFGLSENEP----GTNFVYAQFDGIMGLAYP 185
Query: 186 EIA---------------RLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIR 230
++ L F + S S GG+++ GG+D SLYTG +++ P+
Sbjct: 186 ALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVT 245
Query: 231 REWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASST 290
+E Y+++ I I GQ C E ++IVD+GT+ L +P++ A +++ A
Sbjct: 246 QELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQATGAQEDE 302
Query: 291 EKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVAT 350
G+ LV N + +L + + N + P Y+ T
Sbjct: 303 --------YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPSSYILSNNGYCT 344
Query: 351 SQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 394
+ + ++G V + +Y V+D R+GFA +A
Sbjct: 345 VGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 89.4 bits (220), Expect = 7e-18
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 51/339 (15%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192
Query: 190 LCGAGFPL-----NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREW 233
P+ NQ S+ L SV G +I GGID S YTGSL + P+ E
Sbjct: 193 --SGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEG 250
Query: 234 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 293
Y+++ + + +NG+ + C E ++IVD+GT+ L P I A+ +++
Sbjct: 251 YWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD-- 304
Query: 294 PDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
G+ +V C + P +F T + + P Y+ E S
Sbjct: 305 ------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISG 347
Query: 353 DDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 391
++S ++G V + ++ VFDRA ++G A
Sbjct: 348 FQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 89.4 bits (220), Expect = 7e-18
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 51/339 (15%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192
Query: 190 LCGAGFPL-----NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREW 233
P+ NQ S+ L SV G +I GGID S YTGSL + P+ E
Sbjct: 193 --SGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEG 250
Query: 234 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 293
Y+++ + + +NG+ + C E ++IVD+GT+ L P I A+ +++
Sbjct: 251 YWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD-- 304
Query: 294 PDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
G+ +V C + P +F T + + P Y+ E S
Sbjct: 305 ------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISG 347
Query: 353 DDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 391
++S ++G V + ++ VFDRA ++G A
Sbjct: 348 FQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 89.4 bits (220), Expect = 7e-18
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 51/339 (15%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192
Query: 190 LCGAGFPL-----NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREW 233
P+ NQ S+ L SV G +I GGID S YTGSL + P+ E
Sbjct: 193 --SGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEG 250
Query: 234 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 293
Y+++ + + +NG+ + C E ++IVD+GT+ L P I A+ +++
Sbjct: 251 YWQITVDSITMNGETIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD-- 304
Query: 294 PDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
G+ +V C + P +F T + + P Y+ E S
Sbjct: 305 ------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISG 347
Query: 353 DDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 391
++S ++G V + ++ VFDRA ++G A
Sbjct: 348 FQGMNVP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 87.4 bits (215), Expect = 3e-17
Identities = 98/358 (27%), Positives = 148/358 (41%), Gaps = 64/358 (17%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
YY E+ +G+PPQ ++ DTGSSN V + L H Y SSTY
Sbjct: 79 YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
Query: 129 YVPYTQGKWEGELGTDLVSIPH---------GPNVTVRANIAAITESDKFFINGSNWEGI 179
+ Y G G L D VS+P G R T+ + ++GI
Sbjct: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
Query: 180 LGLAYAEIA--RLCGAGFPLNQSEVL--------------ASVGGSMIIGGIDHSLYTGS 223
LG+AY I+ + L Q +++ A GG +++GG D Y GS
Sbjct: 199 LGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGS 258
Query: 224 LWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVK 282
L Y + R+ Y++V + +VE+ +G L CKE ++IVD+GT+ + P K
Sbjct: 259 LSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAIVDTGTSLMVGPVDEVRELQK 313
Query: 283 SIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQY 341
+I A + GE ++ C + T P I+L L G+ S P+ Y
Sbjct: 314 AIGAVPLIQ--------GEYMIPCEKVST-----LPAITLKLGGKGYKLS------PEDY 354
Query: 342 LRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 394
V + C + S ++G V + +Y VFDR R+GFA +A
Sbjct: 355 TLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/187 (28%), Positives = 92/187 (49%), Gaps = 26/187 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARL 190
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLA-- 193
Query: 191 CGAGFPLNQSEVLASV------------------GGSMIIGGIDHSLYTGSLWYTPIRRE 232
G P+ + + ++ G +I GG DHS ++GSL + P+ ++
Sbjct: 194 VGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQ 253
Query: 233 WYYEVII 239
Y+++ +
Sbjct: 254 AYWQIAL 260
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 73.9 bits (180), Expect = 3e-13
Identities = 79/350 (22%), Positives = 145/350 (41%), Gaps = 61/350 (17%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
Query: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
+ Y+ G G L D++++ +TV +TE + ++G++G+ + E A
Sbjct: 146 TLRYSTGTVSGFLSQDIITV---GGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQA 202
Query: 189 RLCGAGFPL--------------------NQSEVLASVGGSMIIGGIDHSLYTGSLWYTP 228
G P+ SE S+GG +++GG D Y G+ Y
Sbjct: 203 --IGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
Query: 229 IRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 288
+ + +++ + V + L + + ++VD+G + + + S
Sbjct: 261 LIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYIS-------------GSTS 303
Query: 289 STEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDV 348
S EK + ++L + P IS +L G+ T+ Y+ ++
Sbjct: 304 SIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGK------EYTLTSADYV--FQES 355
Query: 349 ATSQDDC----YKFAISQSSTGT-VMGAVIMEGFYVVFDRARKRIGFAVS 393
+S+ C + I + T +GA + FY FDR RIGFA++
Sbjct: 356 YSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 60.8 bits (146), Expect = 3e-09
Identities = 81/313 (25%), Positives = 127/313 (40%), Gaps = 62/313 (19%)
Query: 6 PWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLG--LRLPRETDEEPE----EPGRRGS 59
P LLL V P+ T IR+PL G + LR RE E P+ PG +
Sbjct: 9 PLLLLLPLLNVEPSGATL--IRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPI 66
Query: 60 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYY 113
FV + N R Y+ E+ +G+PPQ + DTGSSN V + F LH +
Sbjct: 67 FVPL-SNYRDVQ---YFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRF 122
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SS+++ + Y G+ +G L D ++I +V
Sbjct: 123 DPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASV-------------IFGE 169
Query: 174 SNWEGILGLAYAEIARLCGAGFPLNQSE-------VLASV-------------------- 206
+ WE L A+A + G GFP+ E VL
Sbjct: 170 ALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPD 229
Query: 207 GGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG 266
GG +++GG D + Y L + P+ Y+++ + RV++ G L + K +I+D+G
Sbjct: 230 GGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKV-GPGLTLCAKGC---AAILDTG 285
Query: 267 TTNLRLPKKVFEA 279
T+ + P + A
Sbjct: 286 TSLITGPTEEIRA 298
>gi|195972905 zinc finger protein 385A isoform b [Homo sapiens]
Length = 305
Score = 35.8 bits (81), Expect = 0.087
Identities = 23/59 (38%), Positives = 29/59 (49%)
Query: 13 GAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
G GV P GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 133 GDGVAPRPGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 191
>gi|110349761 NSL1, MIND kinetochore complex component isoform 2
[Homo sapiens]
Length = 213
Score = 33.5 bits (75), Expect = 0.43
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 232 EWYYEVIIVR-VEINGQ-----------DLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 279
+W +E + + INGQ D + E +D+ IVD T + P+K+ E
Sbjct: 77 QWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILEC 136
Query: 280 AVKSIKA 286
+K+IKA
Sbjct: 137 VIKTIKA 143
>gi|110349759 NSL1, MIND kinetochore complex component isoform 1
[Homo sapiens]
Length = 281
Score = 33.5 bits (75), Expect = 0.43
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 232 EWYYEVIIVR-VEINGQ-----------DLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 279
+W +E + + INGQ D + E +D+ IVD T + P+K+ E
Sbjct: 77 QWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILEC 136
Query: 280 AVKSIKA 286
+K+IKA
Sbjct: 137 VIKTIKA 143
>gi|183396804 Regulation of nuclear pre-mRNA domain containing 2
[Homo sapiens]
Length = 1461
Score = 31.2 bits (69), Expect = 2.2
Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 17/121 (14%)
Query: 26 IRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNL------RGKSGQGYYVEM 79
+ +P+ S LG + P E+ + G + ++ +D G Q ++
Sbjct: 687 LNIPILSSLGSSA-----PSESHPSDFQRGPTSTSIDNIDGTPVRDERSGTPTQDEMMDK 741
Query: 80 TVGSPPQTLNIL---VDTGSSNFAVGAAPHPFLHRYYQRQLS---STYRDLRKGVYVPYT 133
S T+++L + GSS + +P P Y R+LS STYR G PY
Sbjct: 742 PTSSSVDTMSLLSKIISPGSSTPSSTRSPPPGRDESYPRELSNSVSTYRPFGLGSESPYK 801
Query: 134 Q 134
Q
Sbjct: 802 Q 802
>gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
[Homo sapiens]
Length = 406
Score = 30.8 bits (68), Expect = 2.8
Identities = 32/114 (28%), Positives = 41/114 (35%), Gaps = 32/114 (28%)
Query: 41 LRLP---RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSS 97
L+LP R P + G ++ E L G G +PP TL +L+D GS
Sbjct: 91 LQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSK 150
Query: 98 NF---------------------------AVGAAPHPFLHRYYQRQLSSTYRDL 124
AVGA PH F R Y + L + YRDL
Sbjct: 151 QLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPH-FFDRSYDKGL-AWYRDL 202
>gi|195972903 zinc finger protein 385A isoform a [Homo sapiens]
Length = 386
Score = 30.0 bits (66), Expect = 4.8
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 17 LPAH--GTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
L AH GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 216 LEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 272
>gi|24308079 zinc finger protein 385A isoform c [Homo sapiens]
Length = 366
Score = 30.0 bits (66), Expect = 4.8
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 17 LPAH--GTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
L AH GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 196 LEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 252
>gi|44890065 hypothetical protein LOC6936 [Homo sapiens]
Length = 781
Score = 29.6 bits (65), Expect = 6.3
Identities = 14/39 (35%), Positives = 19/39 (48%)
Query: 36 GAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQG 74
GAP L +P +EEP G R + +RG G+G
Sbjct: 30 GAPRELPVPGSAEEEPPSGGGRAQVAGLPHRVRGPRGRG 68
>gi|21361127 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.6 bits (65), Expect = 6.3
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 187 IARLCGAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 239
+ GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 14 VKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
>gi|25777640 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.6 bits (65), Expect = 6.3
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 187 IARLCGAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 239
+ GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 14 VKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
>gi|25777638 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.6 bits (65), Expect = 6.3
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 187 IARLCGAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 239
+ GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 14 VKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
>gi|77917617 hypothetical protein LOC54463 isoform 1 [Homo sapiens]
Length = 497
Score = 29.6 bits (65), Expect = 6.3
Identities = 11/40 (27%), Positives = 22/40 (55%)
Query: 298 WLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITIL 337
++ L+ W TPW ++ +IS+ ++G V Q + +L
Sbjct: 99 FVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVL 138
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 29.3 bits (64), Expect = 8.2
Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 4/89 (4%)
Query: 23 QHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVG 82
+HG + LR G G PLG+ + E +G V + G E G
Sbjct: 198 KHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLAL----ADDGASVLFEAAGG 253
Query: 83 SPPQTLNILVDTGSSNFAVGAAPHPFLHR 111
P +++L++ G S A H +HR
Sbjct: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
Length = 885
Score = 29.3 bits (64), Expect = 8.2
Identities = 17/57 (29%), Positives = 26/57 (45%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVP 131
Y + + S + LV+TG+ ++ PHP + TY+ LRK VY P
Sbjct: 651 YVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSP 707
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,504,066
Number of Sequences: 37866
Number of extensions: 842851
Number of successful extensions: 1853
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1796
Number of HSP's gapped (non-prelim): 35
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.