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Search of human proteins with 209364544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209364544 calsyntenin 2 [Homo sapiens]
(955 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209364544 calsyntenin 2 [Homo sapiens] 1961 0.0
gi|57242755 calsyntenin 1 isoform 2 [Homo sapiens] 1107 0.0
gi|57242757 calsyntenin 1 isoform 1 [Homo sapiens] 1099 0.0
gi|42475534 calsyntenin 3 [Homo sapiens] 892 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 70 7e-12
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 64 5e-10
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 61 4e-09
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 61 4e-09
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 61 4e-09
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 61 4e-09
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 61 6e-09
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 61 6e-09
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 61 6e-09
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 60 7e-09
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 60 1e-08
gi|16933557 dachsous 1 precursor [Homo sapiens] 60 1e-08
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 60 1e-08
gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precurs... 59 2e-08
gi|13470082 protocadherin gamma subfamily B, 4 isoform 1 precurs... 59 2e-08
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 57 8e-08
gi|9256606 protocadherin beta 12 precursor [Homo sapiens] 57 8e-08
gi|9256604 protocadherin beta 11 precursor [Homo sapiens] 57 1e-07
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 56 1e-07
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 56 1e-07
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 56 1e-07
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 56 1e-07
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 56 1e-07
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 56 1e-07
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 56 1e-07
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 56 1e-07
>gi|209364544 calsyntenin 2 [Homo sapiens]
Length = 955
Score = 1961 bits (5080), Expect = 0.0
Identities = 955/955 (100%), Positives = 955/955 (100%)
Query: 1 MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI 60
MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI
Sbjct: 1 MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI 60
Query: 61 LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY 120
LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY
Sbjct: 61 LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY 120
Query: 121 TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ 180
TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ
Sbjct: 121 TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ 180
Query: 181 VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ
Sbjct: 181 VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Query: 241 KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE 300
KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE
Sbjct: 241 KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE 300
Query: 301 LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG 360
LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG
Sbjct: 301 LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG 360
Query: 361 RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN 420
RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN
Sbjct: 361 RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN 420
Query: 421 CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV 480
CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV
Sbjct: 421 CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV 480
Query: 481 TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA 540
TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA
Sbjct: 481 TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA 540
Query: 541 CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR 600
CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR
Sbjct: 541 CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR 600
Query: 601 LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP 660
LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP
Sbjct: 601 LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP 660
Query: 661 DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL 720
DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL
Sbjct: 661 DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL 720
Query: 721 HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS 780
HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS
Sbjct: 721 HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS 780
Query: 781 NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS 840
NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS
Sbjct: 781 NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS 840
Query: 841 VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE 900
VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE
Sbjct: 841 VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE 900
Query: 901 TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY 955
TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY
Sbjct: 901 TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY 955
>gi|57242755 calsyntenin 1 isoform 2 [Homo sapiens]
Length = 971
Score = 1107 bits (2864), Expect = 0.0
Identities = 527/958 (55%), Positives = 707/958 (73%), Gaps = 50/958 (5%)
Query: 34 AAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFE 93
AA+VNKHKPW+E +YHG++TEN++TV+LDPPL+ALDKDAP+ FAGEIC FKIHGQ +PF+
Sbjct: 28 AARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAGEICGFKIHGQNVPFD 87
Query: 94 AVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDV 153
AVV++K++GEG +R+K +DCELQK+Y+F IQAYDCG GP T KKSHKA VHIQV DV
Sbjct: 88 AVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDV 147
Query: 154 NEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
NE+AP FKE +YKA V EGK YDSIL+VEA+D DCSPQ+SQIC+YEI+T DVPF +D++G
Sbjct: 148 NEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDG 207
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPG 273
I+NTEKL+Y K+HQY++ VTAYDCG+K A +D LV++ +KP C PGWQ W RIEY+PG
Sbjct: 208 YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPG 267
Query: 274 SGSMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDL 333
+G++ +FP+IHLETCD V+S+Q EL+T++IGKGCDR+TYSEKSL +LCGA++G +L
Sbjct: 268 TGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAEL 327
Query: 334 LPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKVPDGIVPKNLTDQFTITMWMKHGPS 390
LPSPS + NWT GL D+ S+ +F+F+G Q ++PDG+V + + FTI++WM+HGP
Sbjct: 328 LPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGP- 386
Query: 391 PGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQIC 450
+KETILC+SDKT+MNRHHY+LYVH CRL+FL R+D + +RPAEFHWKL+Q+C
Sbjct: 387 --FGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVC 444
Query: 451 DKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQ------GG 504
D+EWH+YV+NVEFP VTLY+DG ++EP+ VT D+P+HPS I QL VGACWQ
Sbjct: 445 DEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVEND 504
Query: 505 EVTKP----------QFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLG 554
T+P QFF G+LA LT+R GK+ +KVI CL CKEGLD+ LE G
Sbjct: 505 NETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSG 564
Query: 555 QGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDV 614
+G++ +PSQ +L +EG+D+G +++A+Q +SY+NSRQFPT G+RRLK++S ++CF E
Sbjct: 565 RGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEAT 624
Query: 615 CISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAKTEAP 674
CIS+P VD YVMVLQ EP+I+L G HF R A++FES+ GV LFP+++I+ST + P
Sbjct: 625 CISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEP 684
Query: 675 GDVKTTDP---KSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSELHQRHLDATNST 731
DP +S V EE++H+LD C++ V G +L+ QE LE++ + L Q+ ++ ++S
Sbjct: 685 EGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSE 744
Query: 732 AGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNEFNLEVSILH 791
G + GV +M+ YE+VLH +RYRNW SL R+F++ CSELNGRY SNEF +EV+++H
Sbjct: 745 LGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIH 804
Query: 792 EDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHS----------SVVPSIATVVIIISV 841
+ EH NH+ QP F+ HPE RS + S +VVPS ATVVI++ V
Sbjct: 805 --TANPMEHANHMAAQPQFV----HPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCV 858
Query: 842 CMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDET 901
LVF++ +GV+R+R AH+ +++ + KE+EMDWDDSALTITVNPME +E E+E
Sbjct: 859 SFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEE 918
Query: 902 EGEEEEEA----EEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY 955
E EEEEE+ EE+ +S+ S+ SEEEE E+G QN RQ QLEWDDSTL Y
Sbjct: 919 EEEEEEESEDGEEEDDITSAESESSEEEEGEQG-----DPQNATRQQQLEWDDSTLSY 971
>gi|57242757 calsyntenin 1 isoform 1 [Homo sapiens]
Length = 981
Score = 1099 bits (2843), Expect = 0.0
Identities = 527/968 (54%), Positives = 707/968 (73%), Gaps = 60/968 (6%)
Query: 34 AAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFA----------GEICAF 83
AA+VNKHKPW+E +YHG++TEN++TV+LDPPL+ALDKDAP+ FA GEIC F
Sbjct: 28 AARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGF 87
Query: 84 KIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHK 143
KIHGQ +PF+AVV++K++GEG +R+K +DCELQK+Y+F IQAYDCG GP T KKSHK
Sbjct: 88 KIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHK 147
Query: 144 AVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTT 203
A VHIQV DVNE+AP FKE +YKA V EGK YDSIL+VEA+D DCSPQ+SQIC+YEI+T
Sbjct: 148 ATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITP 207
Query: 204 DVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQD 263
DVPF +D++G I+NTEKL+Y K+HQY++ VTAYDCG+K A +D LV++ +KP C PGWQ
Sbjct: 208 DVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQG 267
Query: 264 WTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKL 323
W RIEY+PG+G++ +FP+IHLETCD V+S+Q EL+T++IGKGCDR+TYSEKSL +L
Sbjct: 268 WNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRL 327
Query: 324 CGASSGIIDLLPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKVPDGIVPKNLTDQFT 380
CGA++G +LLPSPS + NWT GL D+ S+ +F+F+G Q ++PDG+V + + FT
Sbjct: 328 CGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFT 387
Query: 381 ITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPA 440
I++WM+HGP +KETILC+SDKT+MNRHHY+LYVH CRL+FL R+D + +RPA
Sbjct: 388 ISVWMRHGP---FGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPA 444
Query: 441 EFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGAC 500
EFHWKL+Q+CD+EWH+YV+NVEFP VTLY+DG ++EP+ VT D+P+HPS I QL VGAC
Sbjct: 445 EFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGAC 504
Query: 501 WQ------GGEVTKP----------QFAQFFHGSLASLTIRPGKMESQKVISCLQACKEG 544
WQ T+P QFF G+LA LT+R GK+ +KVI CL CKEG
Sbjct: 505 WQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEG 564
Query: 545 LDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVS 604
LD+ LE G+G++ +PSQ +L +EG+D+G +++A+Q +SY+NSRQFPT G+RRLK++
Sbjct: 565 LDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKIT 624
Query: 605 SKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKI 664
S ++CF E CIS+P VD YVMVLQ EP+I+L G HF R A++FES+ GV LFP+++I
Sbjct: 625 STIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRI 684
Query: 665 VSTFAKTEAPGDVKTTDP---KSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSELH 721
+ST + P DP +S V EE++H+LD C++ V G +L+ QE LE++ + L
Sbjct: 685 ISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQ 744
Query: 722 QRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSN 781
Q+ ++ ++S G + GV +M+ YE+VLH +RYRNW SL R+F++ CSELNGRY SN
Sbjct: 745 QKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISN 804
Query: 782 EFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHS----------SVVPS 831
EF +EV+++H + EH NH+ QP F+ HPE RS + S +VVPS
Sbjct: 805 EFKVEVNVIH--TANPMEHANHMAAQPQFV----HPEHRSFVDLSGHNLANPHPFAVVPS 858
Query: 832 IATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKH 891
ATVVI++ V LVF++ +GV+R+R AH+ +++ + KE+EMDWDDSALTITVNPME +
Sbjct: 859 TATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETY 918
Query: 892 EGPGHGEDETEGEEEEEA----EEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLE 947
E E+E E EEEEE+ EE+ +S+ S+ SEEEE E+G QN RQ QLE
Sbjct: 919 EDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQG-----DPQNATRQQQLE 973
Query: 948 WDDSTLPY 955
WDDSTL Y
Sbjct: 974 WDDSTLSY 981
>gi|42475534 calsyntenin 3 [Homo sapiens]
Length = 956
Score = 892 bits (2306), Expect = 0.0
Identities = 449/930 (48%), Positives = 617/930 (66%), Gaps = 49/930 (5%)
Query: 36 KVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
K NKHKPWIE Y G++ EN++TV+L+PPL ALDKDAP+ +AGEIC F++HG +PFEAV
Sbjct: 21 KANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAV 80
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
+L+K +GEG +RAK P+DCE QKE+TF IQAYDCG GP KKSHKA VH++V DVNE
Sbjct: 81 ILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNE 140
Query: 156 FAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNI 215
FAP F E Y+A VTEGK+YD IL+VEAID DCSPQYSQIC YEI+T + PF ID +GNI
Sbjct: 141 FAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNI 200
Query: 216 RNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSG 275
NTEKL Y + Y+ VTAYDCG+K AA D V++ VKP CKP WQ W KRIEY PG+G
Sbjct: 201 ENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAG 260
Query: 276 SMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLP 335
S+ LFP I LETCD + ++Q ELQT+++ KGCDR+ YSE++L+KLCGA++G +DLLP
Sbjct: 261 SLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLP 320
Query: 336 SPSAATNWTAGLLV---DSSEMIFKFDGRQGAKVPDGIVP-------KNLTDQFTITMWM 385
P NWTAGL V S +I+ F+G Q +VP G +L+D FT++ WM
Sbjct: 321 MPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWM 380
Query: 386 KHGPSPGV-RAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHW 444
KHG +P + E+ETI+CN+ + E HY+L VH CR+ FL + A RP +F W
Sbjct: 381 KHGVTPNKGKKEEETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESA---RPVKFLW 437
Query: 445 KLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACW--- 501
KL+Q+CD EWH+Y +N+EFP VTLY DG +++P L+ ++ IHP L +GACW
Sbjct: 438 KLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEE 497
Query: 502 ------QGGEVTKP------QFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINS 549
+G T +FHG LA ++R G++ES++VI CL AC+EGLD
Sbjct: 498 KNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRD 557
Query: 550 LESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQC 609
ESLG+G+K H NPSQS+L +EGDD+ N ALQ V+Y+N+ +F T GVR L++++ V+C
Sbjct: 558 FESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKC 617
Query: 610 FGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFA 669
F E+ C+SIPEV+ YV+VLQ P+I L GT HF RPA FE GV LFPD++I + +
Sbjct: 618 FSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSIS 677
Query: 670 -KTEAPGDV--KTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSELHQRHLD 726
+ EA D + T + + +E++HNLD C+I ++G DLDP +E L L+ + L QR L+
Sbjct: 678 HQVEAKKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLE 737
Query: 727 ATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNEFNLE 786
TN++A +I GV S++ YE++L RYR A+L R+FR+ CSE+NGRY+SNEF +E
Sbjct: 738 LTNTSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYSSNEFIVE 797
Query: 787 VSILHEDQVSDKEHVNHLIVQPPFLQSVHHP------ESRSSIQHSSVVPSIATVVIIIS 840
V++LH ++ H +H++ FL H P S +S +S++PS AT++I++
Sbjct: 798 VNVLHS--MNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAATLIIVVC 855
Query: 841 VCMLVFVVAMGVYRVRIAHQHFIQE------TEAAKESEMDWDDSALTITVNPMEKHEGP 894
V LV +V +G+ R+ H+ + K+ ++ WDDSALTI VNPME ++
Sbjct: 856 VGFLVLMVVLGLVRIHSLHRRVSGAGGPPGASSDPKDPDLFWDDSALTIIVNPMESYQNR 915
Query: 895 GH---GEDETEGEEEEEAEEEMSSSSGSDD 921
G + E+E+ ++ E++ S SD+
Sbjct: 916 QSCVTGAVGGQQEDEDSSDSEVADSPSSDE 945
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 70.5 bits (171), Expect = 7e-12
Identities = 49/149 (32%), Positives = 76/149 (51%), Gaps = 11/149 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L+ SP+D E +YT I YD G P + AW+ ++H+ V D N+ P F +
Sbjct: 772 GMLKILSPLDRETTDKYTLNITVYDLGI-PQKAAWR-----LLHVVVVDANDNPPEFLQE 825
Query: 164 AYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGNIRNTEKL 221
+Y V+E K ++ I+QVEA D+D P + Y IVT F+ID G + L
Sbjct: 826 SYFVEVSEDKEVHSEIIQVEATDKDLGP--NGHVTYSIVTDTDTFSIDSVTGVVNIARPL 883
Query: 222 SYDKQHQYEILVTAYD-CGQKPAAQDTLV 249
+ QH++ + + A D ++P T+V
Sbjct: 884 DRELQHEHSLKIEARDQAREEPQLFSTVV 912
Score = 61.6 bits (148), Expect = 3e-09
Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 23/223 (10%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVV 96
+NK P E ++ E +++ + P+V + ++P G + I + PF
Sbjct: 2175 MNKAMPVFEKPFYSA--EIAESIQVHSPVVHVQANSP---EGLKVFYSITDGD-PFSQFT 2228
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
+N +G + +P+D E Y I+A D G H + V I V D+N+
Sbjct: 2229 INFNTGV--INVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF-------VDIIVDDINDN 2279
Query: 157 APTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQ----YSQICNYEIVTTDVPFAIDR 211
P F + +Y ++E + S++QV A D D P Y N+ + F +D
Sbjct: 2280 PPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHS--KSHDHFHVDS 2337
Query: 212 N-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ G I L Y++ Q+ I V A D G + D +V VDV
Sbjct: 2338 STGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDV 2380
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/221 (26%), Positives = 94/221 (42%), Gaps = 18/221 (8%)
Query: 38 NKHKPWIETS-YHGVITENN--DTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEA 94
N H+P TS Y VI E+ +T IL + A+D+D + + P
Sbjct: 1450 NDHRPQFSTSKYEVVIPEDTAPETEILQ--ISAVDQDEKNKLI-----YTLQSSRDPLSL 1502
Query: 95 VVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVN 154
G L +D E ++T + D + K++ +V + V D N
Sbjct: 1503 KKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRD-----QDVPVKRNFARIV-VNVSDTN 1556
Query: 155 EFAPTFKEPAYKAVVTEGKIYDSI-LQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRN- 212
+ AP F +YK V E S+ LQV A+D+D + + E F ID
Sbjct: 1557 DHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVL 1616
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
G+I+ ++L Q +Y+++V A D G P ++ T V++ V
Sbjct: 1617 GSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV 1657
Score = 57.8 bits (138), Expect = 5e-08
Identities = 55/169 (32%), Positives = 83/169 (49%), Gaps = 19/169 (11%)
Query: 93 EAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKD 152
E+ V+++ SG RL+ + +D E K Y F I A C HE V IQVKD
Sbjct: 2749 ESFVIDRQSG--RLKLEKSLDHETTKWYQFSILAR-CTQDDHEMVASVD----VSIQVKD 2801
Query: 153 VNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSP----QYS--QICNYEIVTTDV 205
N+ +P F+ Y+A + E S ++Q+ A D D YS Q + E++ +
Sbjct: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES-- 2859
Query: 206 PFAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
FAI+ G I ++L ++K+ Y+I V A D G+K T + VDV
Sbjct: 2860 -FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAI-VDV 2906
Score = 56.6 bits (135), Expect = 1e-07
Identities = 46/157 (29%), Positives = 72/157 (45%), Gaps = 11/157 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G ++ + P+D ELQ YT ++A D G TA V + V D+N+ P F+
Sbjct: 3179 GIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTA-----TGTVIVSVLDINDNPPVFEYR 3233
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAID-RNGNIRNTE 219
Y A V+E + + +LQV A D Y I++ + F+ID + G + E
Sbjct: 3234 EYGATVSEDILVGTEVLQVYAASRDIEANAE--ITYSIISGNEHGKFSIDSKTGAVFIIE 3291
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
L Y+ H+Y + V A D G + V V+V +
Sbjct: 3292 NLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDI 3328
Score = 55.8 bits (133), Expect = 2e-07
Identities = 45/149 (30%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTE 171
+D E EY ++A D G S A V++ V D+N+ P F + Y V++E
Sbjct: 3293 LDYESSHEYYLTVEATDGGTP------SLSDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346
Query: 172 GKIYD-SILQVEAIDEDCSPQYSQICNYEIV--TTDVPFAIDR-NGNIRNTEKLSYDKQH 227
+ + S++ V A D D P S I +Y I+ F ID G ++ T+ L +
Sbjct: 3347 DAVLEQSVITVMADDAD-GPSNSHI-HYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
Query: 228 QYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
Y + V A D G P T V +DV V
Sbjct: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDV 3433
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/221 (24%), Positives = 96/221 (43%), Gaps = 17/221 (7%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
+N + P + + +Y VI+E D V+ + + DA P I I G + +
Sbjct: 3328 INDNTPVFSQDTYTTVISE--DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQ--GSSF 3383
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
++ GE ++ +D E YT +QA D G+ P + + V+I V DVN+
Sbjct: 3384 TIDPVRGE--VKVTKLLDRETISGYTLTVQASDNGSPP------RVNTTTVNIDVSDVND 3435
Query: 156 FAPTFKEPAYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIVT--TDVPFAIDRN 212
AP F Y ++ E K + S+LQ+ DED S + IVT + F ++
Sbjct: 3436 NAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFF-FTIVTGNDEKAFEVNPQ 3494
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
G + + + ++ Y + V D G+ + T + + V
Sbjct: 3495 GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/155 (28%), Positives = 76/155 (49%), Gaps = 8/155 (5%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + P+D ELQ E++ I+A D + VV + ++DVN+ PTF P
Sbjct: 875 GVVNIARPLDRELQHEHSLKIEARDQAREEPQLF----STVVVKVSLEDVNDNPPTFIPP 930
Query: 164 AYKAVVTEGKIYDSILQ-VEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGNIRNTEKL 221
Y+ V E +++ +EA D D Q Q+ + + F +D+ +G +R ++L
Sbjct: 931 NYRVKVREDLPEGTVIMWLEAHDPDLG-QSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQL 989
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
++K+ Y + V A D G KP + + V+V+ V
Sbjct: 990 DFEKKQVYNLTVRAKDKG-KPVSLSSTCYVEVEVV 1023
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/154 (29%), Positives = 68/154 (44%), Gaps = 11/154 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + +D E Y + A D G P S ++I+V+DVN+ AP EP
Sbjct: 1089 GVIETSDRLDRESTSHYWLTVFATDQGVVP------LSSFIEIYIEVEDVNDNAPQTSEP 1142
Query: 164 AYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI-DRNGNIRNT-EK 220
Y + E D S++Q+EA D D S + F+I + G I T K
Sbjct: 1143 VYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRK 1202
Query: 221 LSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
L ++Q ++ + VT D G P + T+ +V VK
Sbjct: 1203 LDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/143 (23%), Positives = 63/143 (44%), Gaps = 20/143 (13%)
Query: 102 GEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFK 161
G G + P+D E + Y ++A D + V I+V D N+ P F
Sbjct: 1407 GTGTIIVAKPLDAEQKSNYNLTVEATD---------GTTTILTQVFIKVIDTNDHRPQFS 1457
Query: 162 EPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR------NGN 214
Y+ V+ E ++ ILQ+ A+D+D + Y + ++ P ++ + G+
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDEKNKLI----YTLQSSRDPLSLKKFRLDPATGS 1513
Query: 215 IRNTEKLSYDKQHQYEILVTAYD 237
+ +EKL ++ HQ+ + V D
Sbjct: 1514 LYTSEKLDHEAVHQHTLTVMVRD 1536
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/159 (25%), Positives = 65/159 (40%), Gaps = 28/159 (17%)
Query: 91 PFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQV 150
P + E ++ K P+D E + Y I A D S KA+V ++V
Sbjct: 2963 PLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD---------GTFSSKAIVEVKV 3013
Query: 151 KDVNEFAPTFKEPAYKAVVTE----GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
D N+ +P ++ Y + E GK+ I+Q+ A D D N EI T +
Sbjct: 3014 LDANDNSPVCEKTLYSDTIPEDVLPGKL---IMQISATDADIR------SNAEITYTLLG 3064
Query: 207 FAIDR------NGNIRNTEKLSYDKQHQYEILVTAYDCG 239
++ G ++ + L ++Q Y +LV A D G
Sbjct: 3065 SGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG 3103
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/149 (28%), Positives = 68/149 (45%), Gaps = 13/149 (8%)
Query: 93 EAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKD 152
E LN +GE L+ +P+D E Q Y +++A D G + +A + + ++D
Sbjct: 3068 EKFKLNPDTGE--LKTSTPLDREEQAVYHLLVRATDGGG--------RFCQASIVLTLED 3117
Query: 153 VNEFAPTFKEPAYKAVVTEGKIYDSIL-QVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR 211
VN+ AP F Y V E ++L +V+A D D +I I + D F+I+
Sbjct: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLN-RKILYSLIDSADGQFSINE 3176
Query: 212 NGNIRNTEK-LSYDKQHQYEILVTAYDCG 239
I EK L + Q Y + + A D G
Sbjct: 3177 LSGIIQLEKPLDRELQAVYTLSLKAVDQG 3205
Score = 38.9 bits (89), Expect = 0.023
Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 33/210 (15%)
Query: 43 WIETSYHGVITEN---NDTVILDP--PLVA----LDKDAPVPFAGEICAFKIHGQELPFE 93
+++ Y G+I+E+ N V+ D PLV DKD+ I +H +
Sbjct: 1765 FMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVH----TYF 1820
Query: 94 AVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDV 153
A+ S G + +D E + F +Q +D G P A + A V + V D+
Sbjct: 1821 AI----DSSTGAIHTVLSLDYEETSIFHFTVQVHDMGT-PRLFA---EYAANVTVHVIDI 1872
Query: 154 NEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAID 210
N+ P F +P Y+A + ++ V A D D S +SQ+ Y I ++ F++D
Sbjct: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDAD-SSAFSQLI-YSITEGNIGEKFSMD 1930
Query: 211 -RNG--NIRNTEKLSYDKQHQYEILVTAYD 237
+ G ++NT +L + +YE+ V A D
Sbjct: 1931 YKTGALTVQNTTQL----RSRYELTVRASD 1956
Score = 37.7 bits (86), Expect = 0.052
Identities = 34/128 (26%), Positives = 54/128 (42%), Gaps = 9/128 (7%)
Query: 115 ELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-K 173
E++ YT I++A + + V +QV D N+ P F +Y + E
Sbjct: 111 EVKDHYTLIVKALEKNTNVEA-------RTKVRVQVLDTNDLRPLFSPTSYSVSLPENTA 163
Query: 174 IYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILV 233
I SI +V A D D +++ TD+ +G I T +L Y + YE+ +
Sbjct: 164 IRTSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEI 222
Query: 234 TAYDCGQK 241
A D G K
Sbjct: 223 LAADRGMK 230
Score = 37.0 bits (84), Expect = 0.088
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 10/139 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + +D E + Y + A D H + S A+V + V DVN+ P F
Sbjct: 2867 GWITTLKELDHEKRDNYQIKVVASD-----HGEKIQLSSTAIVDVTVTDVNDSPPRFTAE 2921
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAIDRNGN---IRNT 218
YK V+E ++ + + + S + ++ Y I D FA++ N +
Sbjct: 2922 IYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVK 2981
Query: 219 EKLSYDKQHQYEILVTAYD 237
+ L +K+ Y + +TA D
Sbjct: 2982 KPLDREKRDNYLLTITATD 3000
Score = 36.2 bits (82), Expect = 0.15
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 6/98 (6%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTD 204
V ++V N P F + AYKA E I +++ + A+D D + Y I +
Sbjct: 449 VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD--EGENGYVTYSIANLN 506
Query: 205 -VPFAIDR-NGNIRNTEKLSYDKQHQ-YEILVTAYDCG 239
VPFAID G + +E L Y+ + Y + + A D G
Sbjct: 507 HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWG 544
Score = 35.8 bits (81), Expect = 0.20
Identities = 56/248 (22%), Positives = 93/248 (37%), Gaps = 37/248 (14%)
Query: 26 DSRQRRLLAAKVN------KHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGE 79
D R L + K+N H + + Y V+ EN+ + A+ P
Sbjct: 1956 DGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYH 2015
Query: 80 ICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWK 139
I P +++TSG +P D E Q+ + +++ +
Sbjct: 2016 ILN--------PDRRFKISRTSGVLSTTG-TPFDREQQEAFDVVVEVTE----------- 2055
Query: 140 KSHK--AVVHIQVK----DVNEFAPTFKE-PAYKAVVTEGKIYDSILQVEAIDEDCSPQY 192
HK AV H+ VK D N+ AP F P Y V + ++ I V A+D D S +
Sbjct: 2056 -EHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD-SGRN 2113
Query: 193 SQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDK-QHQYEILVTAYDCGQKPAAQDTLVQV 251
++ +Y + F I G I ++ D +Y + V A D G + + +V +
Sbjct: 2114 GEV-HYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPI 2172
Query: 252 DVKPVCKP 259
V P
Sbjct: 2173 TVMNKAMP 2180
Score = 33.9 bits (76), Expect = 0.75
Identities = 39/164 (23%), Positives = 72/164 (43%), Gaps = 13/164 (7%)
Query: 93 EAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKD 152
E + +NK SG + K + + +TF ++A D G+ E+ +V++++
Sbjct: 2644 ENLEINKLSGV--ITTKESLIGLENEFFTFFVRAVDNGSPSKESV------VLVYVKILP 2695
Query: 153 VNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQI-CNYEIVTTDVPFAIDR 211
P F EP Y V+E + + + + + YS + N D F IDR
Sbjct: 2696 PEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDR 2755
Query: 212 -NGNIRNTEKLSYD--KQHQYEILV-TAYDCGQKPAAQDTLVQV 251
+G ++ + L ++ K +Q+ IL D + A+ D +QV
Sbjct: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
Score = 33.5 bits (75), Expect = 0.97
Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 7/90 (7%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G + +D E +++T ++A D G S +V + V D+N+ P F
Sbjct: 2337 SSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPT------LSSDVIVTVDVTDLNDNPPLF 2390
Query: 161 KEPAYKAVVTEGKIYDSILQ-VEAIDEDCS 189
++ Y+A ++E + + V+A D D S
Sbjct: 2391 EQQIYEARISEHAPHGHFVTCVKAYDADSS 2420
Score = 32.3 bits (72), Expect = 2.2
Identities = 35/140 (25%), Positives = 63/140 (45%), Gaps = 18/140 (12%)
Query: 102 GEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFK 161
GE L+ + +D L KEY + A D G + A V + + +N+ P F+
Sbjct: 2133 GEISLKKQFELDT-LNKEYLVTVVAKDGG--------NPAFSAEVIVPITVMNKAMPVFE 2183
Query: 162 EPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTD--VPFAIDRNGNIRNT 218
+P Y A + E +++ ++ V+A SP+ ++ Y I D F I+ N + N
Sbjct: 2184 KPFYSAEIAESIQVHSPVVHVQA----NSPEGLKVF-YSITDGDPFSQFTINFNTGVINV 2238
Query: 219 -EKLSYDKQHQYEILVTAYD 237
L ++ Y++ + A D
Sbjct: 2239 IAPLDFEAHPAYKLSIRATD 2258
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 64.3 bits (155), Expect = 5e-10
Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 25/242 (10%)
Query: 23 GGGDSRQ--RRLLAAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEI 80
GG S Q +L NK P ++ Y+ V N T L P++ +P G
Sbjct: 2148 GGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENIT--LYTPILHTQARSP---EGLR 2202
Query: 81 CAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKK 140
+ I +E ++ G L P+D E + ++ F ++A D G
Sbjct: 2203 LIYNIVEEE---PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFS----- 2254
Query: 141 SHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYE 199
+A V + V+DVN+ PTF + Y ++EG ++Q+ A D+D ++ +Y+
Sbjct: 2255 --EATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR--NRDVSYQ 2310
Query: 200 IVT--TDVPFAIDRNGN---IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
IV +DV NG+ + ++L Y+ Q + + V A D G P +TLV V+V
Sbjct: 2311 IVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVS 2370
Query: 255 PV 256
+
Sbjct: 2371 DI 2372
Score = 55.1 bits (131), Expect = 3e-07
Identities = 66/261 (25%), Positives = 105/261 (40%), Gaps = 30/261 (11%)
Query: 37 VNKHKPWI-ETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN+H+P + Y + EN ++ D L D P +I I G +L +
Sbjct: 3314 VNEHRPQFPQDPYSTRVLEN--ALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTI 3371
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGP-HETAWKKSHKAVVHIQVKDVN 154
K G L+ +D E Y+ ++A D G P HE + IQV DVN
Sbjct: 3372 HPKK----GELQVAKALDREQASSYSLKLRATDSGQPPLHEDT-------DIAIQVADVN 3420
Query: 155 EFAPTFKEPAYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIV--TTDVPFAIDR 211
+ P F + Y V E I +LQ+ D D SP+ ++ I F +
Sbjct: 3421 DNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPD-SPENGPPYSFRITKGNNGSAFRVTP 3479
Query: 212 NGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQ 271
+G + E LS Q Y++ + A D G P + T V+V V T++ Y
Sbjct: 3480 DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHV-----------TEQSHYA 3528
Query: 272 PGSGSMPLFPSIHLETCDGAV 292
P + + +F ++ + G +
Sbjct: 3529 PSALPLEIFITVGEDEFQGGM 3549
Score = 53.9 bits (128), Expect = 7e-07
Identities = 55/209 (26%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 37 VNKHKPWIETS-YHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN ++P E Y V+TEN + A+DKD G++ ++++
Sbjct: 2790 VNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD--GQV-SYRLSADPGSNVHE 2846
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
+ S G + +DCE + Y F + AYD H + S +A+V + + D N+
Sbjct: 2847 LFAIDSESGWITTLQELDCETCQTYHFHVVAYD-----HGQTIQLSSQALVQVSITDEND 2901
Query: 156 FAPTFKEPAYK-AVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP---FAIDR 211
AP F Y+ +VV + + + ++ +D D S Q Q+ Y +T P F I +
Sbjct: 2902 NAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCY--ITEGDPLGQFGISQ 2959
Query: 212 NGN-IRNTEKLSYDKQH--QYEILVTAYD 237
G+ R + + + D++H +Y + VTA D
Sbjct: 2960 VGDEWRISSRKTLDREHTAKYLLRVTASD 2988
Score = 51.6 bits (122), Expect = 3e-06
Identities = 50/158 (31%), Positives = 76/158 (48%), Gaps = 16/158 (10%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G ++ + P+D E K Y + A+ C + V+IQV DVN+ P F+
Sbjct: 2747 GVIKVRKPMDHESTKLYQIDVMAH-CLQNTDVVSLVS-----VNIQVGDVNDNRPVFEAD 2800
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEI-----VTTDVPFAID-RNGNIR 216
YKAV+TE + S++QV AID+D + + Q+ +Y + FAID +G I
Sbjct: 2801 PYKAVLTENMPVGTSVIQVTAIDKD-TGRDGQV-SYRLSADPGSNVHELFAIDSESGWIT 2858
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQK-PAAQDTLVQVDV 253
++L + Y V AYD GQ + LVQV +
Sbjct: 2859 TLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSI 2896
Score = 47.8 bits (112), Expect = 5e-05
Identities = 43/157 (27%), Positives = 68/157 (43%), Gaps = 12/157 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L + +D E +Y I+ +++ S V + + DVNE P F +
Sbjct: 3271 GILYVNASLDFETSPKYFLSIEC------SRKSSSSLSDVTTVMVNITDVNEHRPQFPQD 3324
Query: 164 AYKAVVTEGKIY-DSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAI-DRNGNIRNTE 219
Y V E + D IL V A DED P S I Y ++ + F I + G ++ +
Sbjct: 3325 PYSTRVLENALVGDVILTVSATDED-GPLNSDI-TYSLIGGNQLGHFTIHPKKGELQVAK 3382
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
L ++ Y + + A D GQ P +DT + + V V
Sbjct: 3383 ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADV 3419
Score = 43.9 bits (102), Expect = 7e-04
Identities = 51/224 (22%), Positives = 88/224 (39%), Gaps = 16/224 (7%)
Query: 17 VGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVILDP--PLVALDKDAPV 74
+G + D L ++N + P E + I I P L A D DA
Sbjct: 687 IGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAG- 745
Query: 75 PFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPH 134
F G++ G E + L G L +P+D E Y + YD G P
Sbjct: 746 -FNGKLVYVIADGNEEGCFDIELET----GLLTVAAPLDYEATNFYILNVTVYDLGT-PQ 799
Query: 135 ETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQ 194
+++WK ++ + VKD N+ AP F Y+ ++E + + E +D + +
Sbjct: 800 KSSWK-----LLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI-AELTTKDADSEDNG 853
Query: 195 ICNYEIVTTDVPFAI-DRNGNIRNTEKLSYDKQHQYEILVTAYD 237
Y +++ F++ G + T L + + +Y + V A D
Sbjct: 854 RVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARD 897
Score = 43.9 bits (102), Expect = 7e-04
Identities = 58/246 (23%), Positives = 102/246 (41%), Gaps = 22/246 (8%)
Query: 21 SGGGGDSRQRRLLAAKV-------NKHKPWIETSYH-GVITENNDTVILDPPLVALDKDA 72
S GG +R L +V N H P + H G + EN+ + + A D D+
Sbjct: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061
Query: 73 PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAG 132
+ GE+ F G L A +N+ +G ++ +P+D E Y + A D G+
Sbjct: 1062 GLD--GELQYFLRAGTGLA--AFSINQDTG--MIQTLAPLDREFASYYWLTVLAVDRGSV 1115
Query: 133 PHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA-YKAVVTEGKIYDSILQVEAIDEDCSPQ 191
P + + V+I+V D N+ P + Y ++ + + S+LQ++A D D S +
Sbjct: 1116 PLSSVTE------VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
Query: 192 YSQICNYEIVTTDVPFAIDR-NGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQ 250
N F I G + ++L + + ++ + VT D G+ + V
Sbjct: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229
Query: 251 VDVKPV 256
V + V
Sbjct: 1230 VGILDV 1235
Score = 43.9 bits (102), Expect = 7e-04
Identities = 34/122 (27%), Positives = 54/122 (44%), Gaps = 4/122 (3%)
Query: 143 KAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIV 201
+ +V + ++DVN+ P FK Y ++ +G + D + QV A DED + YE
Sbjct: 2053 QGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGT--NGAVTYEFA 2110
Query: 202 TTDVPFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPG 260
F ID G+I + Y ++Y + V A D G + V V V+ P
Sbjct: 2111 EDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPL 2170
Query: 261 WQ 262
+Q
Sbjct: 2171 FQ 2172
Score = 40.4 bits (93), Expect = 0.008
Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 7/85 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + +D E Q+ + ++A D G P + + +V + V D+N+ P F++P
Sbjct: 2329 GEMSTVQELDYEAQQHFHVKVRAMDKGDPP------LTGETLVVVNVSDINDNPPEFRQP 2382
Query: 164 AYKAVVTE-GKIYDSILQVEAIDED 187
Y+A V+E +L+V+AID D
Sbjct: 2383 QYEANVSELATCGHLVLKVQAIDPD 2407
Score = 38.9 bits (89), Expect = 0.023
Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 19/149 (12%)
Query: 48 YHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGE-GRL 106
Y ++ +NN+ ++ A D D A + +KI L EA+ K G L
Sbjct: 1774 YSMIMDKNNNPFVIH----ASDSDKE---ANSLLVYKI----LEPEALKFFKIDPSMGTL 1822
Query: 107 RAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYK 166
S +D E + F + +D G+ A V I V+DVN+ P F E Y+
Sbjct: 1823 TIVSEMDYESMPSFQFCVYVHDQGS----PVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
Query: 167 AVVTEGKIYD--SILQVEAIDEDCSPQYS 193
+ G I+ +L V A DED YS
Sbjct: 1879 VAIV-GPIHPGMELLMVRASDEDSEVNYS 1906
Score = 38.9 bits (89), Expect = 0.023
Identities = 32/105 (30%), Positives = 56/105 (53%), Gaps = 11/105 (10%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVT-- 202
V+I + N+++P F++ Y+A + E + + ++ + AID+D P Y I +Y I+
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGP-YGTI-DYTIINKL 2524
Query: 203 TDVPFAIDRNGNIRNTEKLSYDKQHQYE----ILVTAYDCGQKPA 243
F+I+ NG I +KL D+++ E I V A D G + A
Sbjct: 2525 ASEKFSINPNGQIATLQKL--DRENSTERVIAIKVMARDGGGRVA 2567
Score = 36.2 bits (82), Expect = 0.15
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 15/139 (10%)
Query: 105 RLRAKSP----IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
R+R KS ++ E++ YT IIQA + + + VVHI D N+ P F
Sbjct: 96 RIRTKSSNTALLNREVRDSYTLIIQATE-----KTLELEALTRVVVHIL--DQNDLKPLF 148
Query: 161 KEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI-DRNGNIRNT 218
P+Y+ ++E + I +V A D D Y T FAI +G +
Sbjct: 149 SPPSYRVTISEDMPLKSPICKVTATDADLGQNAE--FYYAFNTRSEMFAIHPTSGVVTVA 206
Query: 219 EKLSYDKQHQYEILVTAYD 237
KL+ + ++E+ V A D
Sbjct: 207 GKLNVTWRGKHELQVLAVD 225
Score = 31.6 bits (70), Expect = 3.7
Identities = 42/159 (26%), Positives = 68/159 (42%), Gaps = 20/159 (12%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L + +D E + + + +A D G +S +A + + V+DVN+ AP F P
Sbjct: 3065 GELTTLTALDRERKDVFNLVAKATDGGG--------RSCQADITLHVEDVNDNAPRF-FP 3115
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV-----TTDVPFAID-RNGNIRN 217
++ AV ++D+ + + Q N ++V + + F+ID G IR
Sbjct: 3116 SHCAVA----VFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRL 3171
Query: 218 TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+ L Q E+ V A D G P TL V V V
Sbjct: 3172 EKPLQVRPQAPLELTVRASDLG-TPIPLSTLGTVTVSVV 3209
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 348 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 402
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 403 -EIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 453
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E + +V A+D D P NY ++ D P
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK--INY-LLGPDAP 510
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 511 PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 620 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 673
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 730
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Score = 38.1 bits (87), Expect = 0.040
Identities = 40/169 (23%), Positives = 64/169 (37%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 302 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 351
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 408
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 348 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 402
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 403 -EIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 453
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E + +V A+D D P NY ++ D P
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK--INY-LLGPDAP 510
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 511 PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 620 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 673
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 730
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Score = 38.1 bits (87), Expect = 0.040
Identities = 40/169 (23%), Positives = 64/169 (37%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 302 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 351
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 408
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 348 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 402
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 403 -EIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 453
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E + +V A+D D P NY ++ D P
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK--INY-LLGPDAP 510
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 511 PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 620 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 673
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 730
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Score = 38.1 bits (87), Expect = 0.040
Identities = 40/169 (23%), Positives = 64/169 (37%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 302 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 351
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 408
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 348 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 402
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 403 -EIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 453
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E + +V A+D D P NY ++ D P
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK--INY-LLGPDAP 510
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 511 PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 620 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 673
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 730
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Score = 38.1 bits (87), Expect = 0.040
Identities = 40/169 (23%), Positives = 64/169 (37%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 302 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 351
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 408
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 60.8 bits (146), Expect = 6e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 380 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 434
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 435 -EIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 485
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E +++V A D D P NY ++ D P
Sbjct: 486 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE--INY-LLGPDAP 542
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 543 PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 652 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 705
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 706 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 762
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 763 GNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Score = 40.4 bits (93), Expect = 0.008
Identities = 41/169 (24%), Positives = 65/169 (38%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 334 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 383
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 384 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 440
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ N L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/155 (25%), Positives = 60/155 (38%), Gaps = 10/155 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L +D E + +Y F I A D G P + V + + D N+ +P F
Sbjct: 552 GMLTVVKKLDREKEDKYLFTILAKDNGVPP------LTSNVTVFVSIIDQNDNSPVFTHN 605
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNIRNTEKL 221
YK V E + ++ + D D + I+ + F ID + G IR
Sbjct: 606 EYKFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+KQ Y V A D G+ + V ++V V
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 698
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 285
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 377
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 60.8 bits (146), Expect = 6e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 380 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 434
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 435 -EIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 485
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E +++V A D D P NY ++ D P
Sbjct: 486 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE--INY-LLGPDAP 542
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 543 PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 652 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 705
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 706 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 762
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 763 GNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Score = 40.4 bits (93), Expect = 0.008
Identities = 41/169 (24%), Positives = 65/169 (38%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 334 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 383
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 384 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 440
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ N L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/155 (25%), Positives = 60/155 (38%), Gaps = 10/155 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L +D E + +Y F I A D G P + V + + D N+ +P F
Sbjct: 552 GMLTVVKKLDREKEDKYLFTILAKDNGVPP------LTSNVTVFVSIIDQNDNSPVFTHN 605
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNIRNTEKL 221
YK V E + ++ + D D + I+ + F ID + G IR
Sbjct: 606 EYKFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+KQ Y V A D G+ + V ++V V
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 698
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 285
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 377
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 60.8 bits (146), Expect = 6e-09
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPL-----VAL----DKDAPVPFAGEICAFKIHG 87
VN + P I+ Y ++ NDTV+L + +AL DKDA G + F H
Sbjct: 369 VNDNVPSIDIRY--IVNPVNDTVVLSENIPLNTKIALITVTDKDAD--HNGRVTCFTDH- 423
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
E+PF + S + L + +D E KEY + A D G P + A++
Sbjct: 424 -EIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP------LNQSAMLF 474
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
I+VKD N+ AP F + + E +++V A D D P NY ++ D P
Sbjct: 475 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE--INY-LLGPDAP 531
Query: 207 --FAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F++D R G + +KL +K+ +Y + A D G P + V V +
Sbjct: 532 PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 581
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/148 (33%), Positives = 66/148 (44%), Gaps = 17/148 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R D E Q+ YTF ++A D G +S A V I V DVN+ P F
Sbjct: 641 SQTGVIRPNISFDREKQESYTFYVKAEDGGRV------SRSSSAKVTINVVDVNDNKPVF 694
Query: 161 KEP----AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIV---TTDVPFAIDR-N 212
P +Y+ V+ + QV A+D D + Y IV T D+ FAID+
Sbjct: 695 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL-FAIDQET 751
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
GNI EK + +LV A D GQ
Sbjct: 752 GNITLMEKCDVTDLGLHRVLVKANDLGQ 779
Score = 40.4 bits (93), Expect = 0.008
Identities = 41/169 (24%), Positives = 65/169 (38%), Gaps = 24/169 (14%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
LN T+G + K P+D E + ++ A D G P +A+V + V DVN+
Sbjct: 323 LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDN 372
Query: 157 APTFK-----EPAYKAVVTEGKI--YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
P+ P VV I I + D+D C ++PF +
Sbjct: 373 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRL 429
Query: 210 ----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ N L Y+ +Y I + A D G+ P Q ++ + VK
Sbjct: 430 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 478
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/155 (25%), Positives = 60/155 (38%), Gaps = 10/155 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L +D E + +Y F I A D G P + V + + D N+ +P F
Sbjct: 541 GMLTVVKKLDREKEDKYLFTILAKDNGVPP------LTSNVTVFVSIIDQNDNSPVFTHN 594
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNIRNTEKL 221
YK V E + ++ + D D + I+ + F ID + G IR
Sbjct: 595 EYKFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+KQ Y V A D G+ + V ++V V
Sbjct: 653 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 687
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 105 RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPA 164
+L + +D E + Y ++ D G ++S A++ + V D N+ P FKE
Sbjct: 221 QLIVQKELDREEKDTYVMKVKVEDGGFP------QRSSTAILQVSVTDTNDNHPVFKETE 274
Query: 165 YKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI----DRNGNIRNTE 219
+ + E + S+ Q+ A D D ++ + +++ + G I E
Sbjct: 275 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
L ++ +++LV A D G PA LV V
Sbjct: 335 PLDREETPNHKLLVLASDGGLMPARAMVLVNV 366
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 60.5 bits (145), Expect = 7e-09
Identities = 60/215 (27%), Positives = 91/215 (42%), Gaps = 12/215 (5%)
Query: 38 NKHKPWIETS-YHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVV 96
N H P E + Y + EN + L A D DAP P A F A
Sbjct: 427 NDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAP-PNANLRYRFVGPPAARAAAAAA 485
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
G + +D E + Y +++A D G P +S VHI V D N+
Sbjct: 486 FEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGP----RSATVRVHITVLDENDN 541
Query: 157 APTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAIDR-N 212
AP F E Y A V E + + +L+V A D D + + +Y I++ + FAID
Sbjct: 542 APQFSEKRYVAQVREDVRPHTVVLRVTATDRD--KDANGLVHYNIISGNSRGHFAIDSLT 599
Query: 213 GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDT 247
G I+ L ++ + +Y + + A D G+ P + +T
Sbjct: 600 GEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNT 634
Score = 54.7 bits (130), Expect = 4e-07
Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 7/155 (4%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF-KE 162
G ++ +P+D E ++EY I+A D G P ++ + IQV D+N+ P F
Sbjct: 600 GEIQVVAPLDFEAEREYALRIRAQDAGRPP-----LSNNTGLASIQVVDINDHIPIFVST 654
Query: 163 PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNIRNTEKL 221
P +V+ + S++ ++A+D D + V D PF I+ G + + L
Sbjct: 655 PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPL 714
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+ Y V A D G P + V V V V
Sbjct: 715 DRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV 749
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/159 (30%), Positives = 71/159 (44%), Gaps = 15/159 (9%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + ++P+D E Q YT I A D G +K+ V + V DVN+ AP F
Sbjct: 911 GAITLQAPLDYEDQVTYTLAITARDNGIP------QKADTTYVEVMVNDVNDNAPQFVAS 964
Query: 164 AYKAVVTE-GKIYDSILQVEAIDEDCSP----QYSQICNYEIVTTDVPFAID-RNGNIRN 217
Y +V+E + S+LQ+ A D D QY+ N E D F I+ +G +R
Sbjct: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT-FQNGE--DGDGDFTIEPTSGIVRT 1021
Query: 218 TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+L + YE+ A D G P +QV V+ V
Sbjct: 1022 VRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDV 1060
Score = 53.5 bits (127), Expect = 9e-07
Identities = 60/244 (24%), Positives = 100/244 (40%), Gaps = 36/244 (14%)
Query: 27 SRQRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIH 86
S R N+H + + +Y ++ EN +VA D DA GE
Sbjct: 309 SANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDA-----GEA------ 357
Query: 87 GQELPFEAVVLNKTSGE--------GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAW 138
G+ + A ++N S E G +R + +D E + + + A D G+
Sbjct: 358 GRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP------ 411
Query: 139 KKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICN 197
+ S +V + V D N+ +P F++ Y+ + E ILQ+ A D D P +
Sbjct: 412 RLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNAN--LR 469
Query: 198 YEIV-------TTDVPFAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLV 249
Y V F ID R+G I + ++ + YE++V A D GQ+P + V
Sbjct: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
Query: 250 QVDV 253
+V +
Sbjct: 530 RVHI 533
Score = 50.4 bits (119), Expect = 8e-06
Identities = 52/222 (23%), Positives = 88/222 (39%), Gaps = 18/222 (8%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN ++P + YH + E+ + A+D+DA + +I +
Sbjct: 749 VNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNR------F 802
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
++ G G + P+D + ++ + ++ A D H VHI + D N
Sbjct: 803 AISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH---------CYVHINITDANT 853
Query: 156 FAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGN 214
P F+ Y V E + S + V + +D + ++I Y + F ID +G
Sbjct: 854 HRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARI-TYLLEDNLPQFRIDADSGA 912
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
I L Y+ Q Y + +TA D G A T V+V V V
Sbjct: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDV 954
Score = 49.3 bits (116), Expect = 2e-05
Identities = 54/215 (25%), Positives = 92/215 (42%), Gaps = 18/215 (8%)
Query: 26 DSRQRRLLAAKVNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFK 84
D+ ++ VN + P ++ + Y G+++E+ + A D+DA A +
Sbjct: 943 DTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDA---HANGRVQYT 999
Query: 85 IHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKA 144
E + TSG +R +D E Y A D G P T
Sbjct: 1000 FQNGEDGDGDFTIEPTSGI--VRTVRRLDREAVSVYELTAYAVDRGVPPLRTP------V 1051
Query: 145 VVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL-QVEAIDEDCSPQYSQICNYEIVTT 203
+ + V+DVN+ AP F ++ V E I S++ Q+ A+D D P + Y+IV
Sbjct: 1052 SIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIM--YQIVEG 1109
Query: 204 DVP--FAID-RNGNIRNTEKLSYDKQHQYEILVTA 235
++P F +D +G + L Y+ + +Y I+V A
Sbjct: 1110 NIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
Score = 44.7 bits (104), Expect = 4e-04
Identities = 40/143 (27%), Positives = 63/143 (44%), Gaps = 16/143 (11%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G + P+D E + Y F ++A D G+ P S A V + V DVN+ P F
Sbjct: 703 SATGWVSVSGPLDRESVEHYFFGVEARDHGSPP------LSASASVTVTVLDVNDNRPEF 756
Query: 161 KEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIV--TTDVPFAIDRNGNIRN 217
Y + E + S++ V A+D D + S Y+I T FAI G +
Sbjct: 757 TMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAIS----YQITGGNTRNRFAISTQGGVGL 812
Query: 218 TE---KLSYDKQHQYEILVTAYD 237
L Y ++ +++++TA D
Sbjct: 813 VTLALPLDYKQERYFKLVLTASD 835
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 60.1 bits (144), Expect = 1e-08
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 29/227 (12%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQ---ELPF 92
VN + P + + Y VI+E D ++ D ++ + +D G+I ++G E
Sbjct: 3334 VNDNPPKFSQDVYSAVISE--DALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTV 3391
Query: 93 EAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKD 152
+ V+ G ++ K +D E Y+ ++QA D G S A V+I + D
Sbjct: 3392 DPVL-------GLVKVKKKLDRERVSGYSLLVQAVDSGIPA------MSSTATVNIDISD 3438
Query: 153 VNEFAPTFKEPAYKAVVTEGK-IYDSILQVEAIDEDC---SPQYSQICNYEIVT--TDVP 206
VN+ +P F Y AV+ E K + SILQ+ D D P +S + I++ +
Sbjct: 3439 VNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFS----FSILSGNEEEE 3494
Query: 207 FAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
F +D +G +R+ + + +Y + V A D G+ T ++V V
Sbjct: 3495 FVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRV 3541
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + +D EL K + +++A D G S A V+I + DVN+ P F +
Sbjct: 3291 GGISVSEVLDYELCKRFYLVVEAKDGGTPA------LSAVATVNINLTDVNDNPPKFSQD 3344
Query: 164 AYKAVVTEGKIY-DSILQVEAIDEDCSPQYSQICNYEIVT--TDVPFAIDR-NGNIRNTE 219
Y AV++E + DS++ + A D D P QI ++ IV D F +D G ++ +
Sbjct: 3345 VYSAVISEDALVGDSVILLIAEDVDSQPN-GQI-HFSIVNGDRDNEFTVDPVLGLVKVKK 3402
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
KL ++ Y +LV A D G + V +D+ V
Sbjct: 3403 KLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439
Score = 55.5 bits (132), Expect = 2e-07
Identities = 55/226 (24%), Positives = 98/226 (43%), Gaps = 23/226 (10%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVV 96
VNK P + ++ N+ + ++ P+++++ A P I I G PF+
Sbjct: 2179 VNKAMPVFDKPFYTASV--NEDIRMNTPILSIN--ATSPEGQGIIYIIIDGD--PFKQ-- 2230
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
N G L+ SP+D E+ Y I+A D G + V + V DVN+
Sbjct: 2231 FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARA-------EVTVDLLVNDVNDN 2283
Query: 157 APTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIV-----TTDVPFAID 210
P F +P Y ++E + + +LQV +ID D + +++ +Y+IV +TD
Sbjct: 2284 PPIFDQPTYNTTLSEASLIGTPVLQVVSIDAD--SENNKMVHYQIVQDTYNSTDYFHIDS 2341
Query: 211 RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+G I L ++ + V + D G + + LV + + V
Sbjct: 2342 SSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDV 2387
Score = 53.5 bits (127), Expect = 9e-07
Identities = 53/215 (24%), Positives = 90/215 (41%), Gaps = 38/215 (17%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVV 96
+N+ P+ + S+ P VA+ +D PV I K + + F V
Sbjct: 718 INRQGPYFDKSF--------------PSDVAVKEDLPV--GANILKIKAYDADSGFNGKV 761
Query: 97 L------------NKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKA 144
L N G+L+ P+D E Y I YD G P +++W+
Sbjct: 762 LFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLG-NPQKSSWR----- 815
Query: 145 VVHIQVKDVNEFAPTFKEPAYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIVTT 203
++ I V+D N+ +P F + +Y + E I I+QVEA D+D Y ++T
Sbjct: 816 LLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGE--VTYSVLTD 873
Query: 204 DVPFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYD 237
FAI+ + G + ++L + + Y + + A D
Sbjct: 874 TQQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 13/155 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + A +D E Y + A D G P + + V+I+V+DVN+ AP EP
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIE------VYIEVEDVNDNAPLTSEP 1151
Query: 164 AYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP--FAID-RNGNIRNT- 218
Y VV E D S++Q++A D D S ++ Y I + + FAI+ + G I T
Sbjct: 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSS--NEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Query: 219 EKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
KL ++Q ++ + VT D G P V V V
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQV 1244
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/116 (31%), Positives = 60/116 (51%), Gaps = 7/116 (6%)
Query: 143 KAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIV 201
KA V I ++D N+ P F++P Y A V E + S+L V A D+D + Y I
Sbjct: 455 KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGE--NGYITYSIA 512
Query: 202 TTD-VPFAIDR-NGNIRNTEKLSYDKQHQ-YEILVTAYDCGQKPAAQDTLVQVDVK 254
+ + +PF I++ G I TE+L ++ + Y +V A D G P ++ V V ++
Sbjct: 513 SLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWG-SPYRHESEVNVTIR 567
Score = 47.0 bits (110), Expect = 9e-05
Identities = 36/128 (28%), Positives = 58/128 (45%), Gaps = 9/128 (7%)
Query: 115 ELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-K 173
E+Q Y I++ G AW K V+IQV D+N+ P F Y + E
Sbjct: 120 EIQDNYLLIVKG--SVRGEDLEAWTK-----VNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
Query: 174 IYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILV 233
+ S+ QV A D D + Y D+ +G I + +L+YD++++Y++ +
Sbjct: 173 LRTSVAQVTATDADIGSN-GEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEI 231
Query: 234 TAYDCGQK 241
A D G K
Sbjct: 232 LAVDRGMK 239
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 11/162 (6%)
Query: 37 VNKHKPWIETS-YHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
+N +KP ETS Y +I E + A+D D G++ + +H P + +
Sbjct: 2807 LNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGAN--GQV-TYSLHSDSQPEKVM 2863
Query: 96 -VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVN 154
N S G + +D E +TF + A D G A+ S A+V ++V D+N
Sbjct: 2864 EAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-----AFSLSSTALVSVRVTDIN 2918
Query: 155 EFAPTFKEPAYKAVVTEGKIYDSILQV-EAIDEDCSPQYSQI 195
+ AP F + Y+ V E ++ V D D S Q+
Sbjct: 2919 DNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQV 2960
Score = 42.7 bits (99), Expect = 0.002
Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 12/139 (8%)
Query: 102 GEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFK 161
G G + P+D E + Y ++ D G T V I+V D N+ P F
Sbjct: 1411 GVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAVTQ--------VFIKVLDNNDNGPEFS 1461
Query: 162 EPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDV-PFAID-RNGNIRNT 218
+P Y ++E + D+ ILQ+EA D D + S + I + + F ID G +
Sbjct: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Query: 219 EKLSYDKQHQYEILVTAYD 237
E+L ++ Q ++ + + D
Sbjct: 1522 ERLDHEAQDKHILNIMVRD 1540
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/152 (25%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L +D E Q ++ I D E ++++ V+ + V+D N+ +P F P
Sbjct: 1516 GVLYTAERLDHEAQDKHILNIMVRD-----QEFPYRRNLARVI-VNVEDANDHSPYFTNP 1569
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGNIRNTEKL 221
Y+A V E S +LQV A+D+D I E T F I+ G I ++
Sbjct: 1570 LYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEP 1629
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
Q+ + + D G P + +V++ V
Sbjct: 1630 DMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Score = 41.6 bits (96), Expect = 0.004
Identities = 43/151 (28%), Positives = 70/151 (46%), Gaps = 13/151 (8%)
Query: 111 PIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKE-PAYKAVV 169
P D E Q+ Y +++A E + + VV + ++D+N+ +P F P Y AV
Sbjct: 2041 PFDREEQELYELVVEA------SRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQ 2094
Query: 170 TEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRN-GNIRNTEKLSYDKQH- 227
+ + I QV AID+D P Y + F I+ N GN+ E + D +
Sbjct: 2095 VDAEPGTLIYQVTAIDKDKGPNGE--VTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNI 2152
Query: 228 QYEILVTAYDCGQKPAAQDTLVQVDVKPVCK 258
+Y + + A D G KP+ T V++ + V K
Sbjct: 2153 EYGVTILAKD-GGKPSL-STSVELPITIVNK 2181
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 16/162 (9%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G + +D E + Y+ I+A D E+ + + + + DVN+ +P F
Sbjct: 881 SSTGIVYVADQLDRESKANYSLKIEARDKA----ESGQQLFSVVTLKVFLDDVNDCSPAF 936
Query: 161 KEPAYKAVVTEGKIYDSILQ-VEAIDEDCS----PQYSQICNYEIVTTDVPFAIDR-NGN 214
+Y V E +++ +E D D +YS + +Y + F ID+ +G
Sbjct: 937 IPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDY-----NGRFEIDKASGA 991
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
IR +++L Y+KQ Y + V A D G +P + ++ V+V+ V
Sbjct: 992 IRLSKELDYEKQQFYNLTVRAKDKG-RPVSLSSVSFVEVEVV 1032
Score = 41.2 bits (95), Expect = 0.005
Identities = 52/228 (22%), Positives = 89/228 (39%), Gaps = 32/228 (14%)
Query: 38 NKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVL 97
N H +I Y + EN D + ++ + + E+ I+G +
Sbjct: 1666 NSHPKFIHKDYQAEVNENVD---IGTSVILISAISQSTLIYEVKDGDING------IFTI 1716
Query: 98 NKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFA 157
N SG + + +D E Y IIQA + + A V+IQ+ D N+ A
Sbjct: 1717 NPYSGV--ITTQKALDYERTSSYQLIIQATNMAG--------MASNATVNIQIVDENDNA 1766
Query: 158 PTFKEPAYKAVVTEGKIYDSI--------LQVEAIDEDCSPQYSQICNYEIV--TTDVPF 207
P F Y ++E +SI L + A D D + + + Y+IV T F
Sbjct: 1767 PVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN--RNALLVYQIVESTAKKFF 1824
Query: 208 AIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+D + G IR L ++ + V D G ++ V+V+++
Sbjct: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIE 1872
Score = 40.4 bits (93), Expect = 0.008
Identities = 55/251 (21%), Positives = 92/251 (36%), Gaps = 15/251 (5%)
Query: 9 VPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETS-YHGVITENNDTVILDPPLVA 67
+P+ + + GG L+ VN + P + Y+ + EN T L + A
Sbjct: 3096 IPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQA 3155
Query: 68 LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAY 127
+D D + K+ V + S G + + P+D E Q Y ++A
Sbjct: 3156 VDPDIGINR-------KVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRAT 3208
Query: 128 DCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDE 186
D G S V I V D+N+ P F+ Y V E + +L V A +
Sbjct: 3209 DQSPGQ-----SLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSK 3263
Query: 187 DCSPQYSQICNYEIVTTDVPFAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQ 245
D F I+ + G I +E L Y+ ++ ++V A D G +
Sbjct: 3264 DIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSA 3323
Query: 246 DTLVQVDVKPV 256
V +++ V
Sbjct: 3324 VATVNINLTDV 3334
Score = 40.0 bits (92), Expect = 0.010
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 7/101 (6%)
Query: 144 AVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVT 202
A VHI+V N ++P F + Y A V E + ++ V A D D Y QI +Y I+
Sbjct: 2480 AQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD-PGTYGQI-SYAIIN 2537
Query: 203 TDVP--FAIDRNGNIRNTEKLSYDK--QHQYEILVTAYDCG 239
F ID NG + TE+L + + I V A D G
Sbjct: 2538 DFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGG 2578
Score = 39.3 bits (90), Expect = 0.018
Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 15/160 (9%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE--FAPTFK 161
G +R +D E Q+ Y ++A D G S + V ++V DVNE P F
Sbjct: 990 GAIRLSKELDYEKQQFYNLTVRAKDKGRPV-----SLSSVSFVEVEVVDVNENLHTPYFP 1044
Query: 162 EPAYKAVVTEG-KIYDSILQVEAIDEDCSP----QYSQICNYEIVTTDVPFAIDRNGNIR 216
+ A V E +I S+LQV A DED QYS + + D +G I
Sbjct: 1045 DFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID---DESGVIT 1101
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
+ L + Y + V A D G P V ++V+ V
Sbjct: 1102 AADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDV 1141
Score = 37.0 bits (84), Expect = 0.088
Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 11/136 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L+ + +D E Y+ + +A D G + ++ +H+ ++DVN+ P F
Sbjct: 3083 GELKTLALLDRERIPVYSLMAKATDGGG--------RFCQSNIHLILEDVNDNPPVFSSD 3134
Query: 164 AYKAVVTEGKIYDSIL-QVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEK-L 221
Y V E ++L +V+A+D D + + V F+ID + I E+ L
Sbjct: 3135 HYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV-FSIDSSSGIIILEQPL 3193
Query: 222 SYDKQHQYEILVTAYD 237
++Q Y I V A D
Sbjct: 3194 DREQQSSYNISVRATD 3209
Score = 36.6 bits (83), Expect = 0.11
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 7/118 (5%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQ----YSQICNYEI 200
V I+V D+N+ P F+ +Y ++ EG + + QV AID D YS + +
Sbjct: 2800 VDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQP 2859
Query: 201 VTTDVPFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDT-LVQVDVKPV 256
F ID N G I + L ++ + V A D G+ + T LV V V +
Sbjct: 2860 EKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDI 2917
Score = 35.8 bits (81), Expect = 0.20
Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 9/139 (6%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G +R + +D E + F + D G+ P TA V+I+V DVN+ P F
Sbjct: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGS-PQLTA---ESPVEVNIEVTDVNDNPPVF 1883
Query: 161 KEPAYKAV-VTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-FAIDRNGNIRNT 218
+ ++ + + + +L+V A D D + Y ++ + F ID N +
Sbjct: 1884 TQAVFETILLLPTYVGVEVLKVSATDPD--SEVPPELTYSLMEGSLDHFLIDSNSGVLTI 1941
Query: 219 EKLSYDKQHQYEILVTAYD 237
+ + K H Y ++V D
Sbjct: 1942 KNNNLSKDH-YMLIVKVSD 1959
Score = 33.9 bits (76), Expect = 0.75
Identities = 54/225 (24%), Positives = 93/225 (41%), Gaps = 26/225 (11%)
Query: 37 VNKHKPWI-ETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN + P E Y+ V+ EN+ D ++ + + P + E ++I P
Sbjct: 1141 VNDNAPLTSEPIYYPVVMENSPK---DVSVIQIQAEDPDSSSNEKLTYRITSGN-PQNFF 1196
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHE-TAWKKSHKAVVHIQVKDVN 154
+N +G ++ +D E Q E+ + D G P + T W V +QV D N
Sbjct: 1197 AINIKTGLITTTSRK-LDREQQAEHFLEVTVTDGGPSPKQSTIW-------VVVQVLDEN 1248
Query: 155 EFAPTFKEPAYKAVVTE---GKIYDSILQVEAIDEDCSPQYSQICNYEIV--TTDVPFAI 209
+ P F E Y+ + E K + I + A D D P +Y IV D F I
Sbjct: 1249 DNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE--ISYSIVDGNDDGKFFI 1306
Query: 210 D-RNGNIRNTEKLSYDKQHQYEIL-VTAYDCGQKPAAQDTLVQVD 252
D + G + + ++ + Y+IL + A D G+ + + ++
Sbjct: 1307 DPKTGMVSSRKQFT---AGSYDILTIKAVDNGRPQKSSTARLHIE 1348
Score = 33.5 bits (75), Expect = 0.97
Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 6/71 (8%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G + +D EL + T +++ D G S + +VHI + DVN+ P F
Sbjct: 2341 SSSGLILTARMLDHELVQHCTLKVRSIDSGFP------SLSSEVLVHIYISDVNDNPPVF 2394
Query: 161 KEPAYKAVVTE 171
+ Y++ V+E
Sbjct: 2395 NQLIYESYVSE 2405
Score = 32.0 bits (71), Expect = 2.8
Identities = 29/100 (29%), Positives = 52/100 (52%), Gaps = 12/100 (12%)
Query: 90 LPFEAVVLNKTSGEGRLRAKSPIDCELQKE-YTFIIQAYDCGAGPHETAWKKSHKAVVHI 148
LPF V+N+ +G + +D E E Y FI++A D G+ ++ + V I
Sbjct: 517 LPF---VINQFTGV--ISTTEELDFESSPEIYRFIVRASDWGS-----PYRHESEVNVTI 566
Query: 149 QVKDVNEFAPTFKEPAYKAVVT-EGKIYDSILQVEAIDED 187
++ +VN+ +P F++ A + V++ + + I V AID D
Sbjct: 567 RIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID 606
Score = 30.4 bits (67), Expect = 8.2
Identities = 54/207 (26%), Positives = 85/207 (41%), Gaps = 27/207 (13%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
+N + P ++ Y+ + + + L + A+DKD GE+ + + FE
Sbjct: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN--GEV-TYVLQDDYGHFE-- 2131
Query: 96 VLNKTSGEGRLRAKSPIDCELQK-EYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVN 154
+N SG L K + +L EY I A D G K S V + + VN
Sbjct: 2132 -INPNSGNVIL--KEAFNSDLSNIEYGVTILAKDGG--------KPSLSTSVELPITIVN 2180
Query: 155 EFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTD--VPFAID- 210
+ P F +P Y A V E ++ IL + A SP+ I Y I+ D F ID
Sbjct: 2181 KAMPVFDKPFYTASVNEDIRMNTPILSINA----TSPEGQGII-YIIIDGDPFKQFNIDF 2235
Query: 211 RNGNIRNTEKLSYDKQHQYEILVTAYD 237
G ++ L Y+ Y++ + A D
Sbjct: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASD 2262
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/149 (30%), Positives = 73/149 (48%), Gaps = 14/149 (9%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTE 171
+D E + Y ++AYD G+ P +A++ + + D+N+ AP F + Y AVV+E
Sbjct: 213 LDRENRSHYMLQLEAYDGGSPPRRA------QALLDVTLLDINDHAPAFNQSRYHAVVSE 266
Query: 172 GKIYDS-ILQVEAIDEDCSPQYSQICNYEI----VTTDVPFAIDRNGNIRNTEK-LSYDK 225
S +LQV A D D + YEI D PF+ID + + E+ L +++
Sbjct: 267 SLAPGSPVLQVFASDADAG--VNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQ 324
Query: 226 QHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ +E++V A D G P V V V+
Sbjct: 325 RRVHELVVQARDGGAHPELGSAFVTVHVR 353
Score = 51.2 bits (121), Expect = 5e-06
Identities = 46/157 (29%), Positives = 76/157 (48%), Gaps = 13/157 (8%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G L P+D E + E+ + A D G+ P +S V+ + V DVN+ APTF
Sbjct: 1596 SSTGALSVVRPLDREQRAEHVLTVVASDHGSPP------RSATQVLTVSVADVNDEAPTF 1649
Query: 161 KEPAYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTE 219
++ Y ++ E S+L + A D D Q+ Y V+++ F++D + + T
Sbjct: 1650 QQQEYSVLLRENNPPGTSLLTLRATDPDVGAN-GQV-TYGGVSSE-SFSLDPDTGVLTTL 1706
Query: 220 KLSYDKQHQYEILVTAY--DCGQKPAAQDTLVQVDVK 254
+ + D++ Q EI +T Y D G P V+V V+
Sbjct: 1707 R-ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742
Score = 47.4 bits (111), Expect = 7e-05
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 16/156 (10%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
GR+ P+D E Y + A+D GPHE +A + + V+DVN+ AP F +
Sbjct: 2329 GRVSLTGPLDFEQCDRYQLQLLAHD---GPHEG------RANLTVLVEDVNDNAPAFSQS 2379
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG----NIRNT 218
Y+ ++ E S IL V A D D + +Y + + F++D N I T
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGA--NGHISYHLASPADGFSVDPNNGTLFTIVGT 2437
Query: 219 EKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
L +D ++++ A D G A V V ++
Sbjct: 2438 VALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQ 2473
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/194 (26%), Positives = 78/194 (40%), Gaps = 30/194 (15%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G LR +DCE Q + ++QA D AG H A V I+V+DVN+ P F
Sbjct: 2657 GTLRLAHALDCETQARHQLVVQAAD-PAGAHFAL------APVTIEVQDVNDHGPAFPLN 2709
Query: 164 AYKAVVTEGKIYDSIL-QVEAIDEDCSP----QYSQICNYEIVTTDVPFAIDRN-GNIRN 217
V E + +++ + AID D +YS + FA++ + G +R
Sbjct: 2710 LLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRA 2769
Query: 218 TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSM 277
Y+ + +LV A D G A+ V V T EY P +
Sbjct: 2770 RVPFDYEHTESFRLLVGAADAGNLSASVTVSVLV-------------TGEDEYDP----V 2812
Query: 278 PLFPSIHLETCDGA 291
L P+ H + +GA
Sbjct: 2813 FLAPAFHFQVPEGA 2826
Score = 44.7 bits (104), Expect = 4e-04
Identities = 44/152 (28%), Positives = 70/152 (46%), Gaps = 25/152 (16%)
Query: 123 IIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQV 181
+++A D GA P A +A VH+Q++D N+ AP+F Y+ VTE S +L +
Sbjct: 2451 VLEARDHGA-PGRAA-----RATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
Query: 182 EAIDEDCSPQYSQICNYEIVTTD--VPFAIDRN---------------GNIRNTEKLSYD 224
EA D D S ++ + +Y I++ + F ++ G + E L ++
Sbjct: 2505 EATDADGSRSHAAV-DYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFE 2563
Query: 225 KQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
QY + V A D GQ P + V V V V
Sbjct: 2564 SLTQYNLTVAAADRGQPPQSSVVPVTVTVLDV 2595
Score = 43.5 bits (101), Expect = 0.001
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 16/144 (11%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + + +D EL+ + I+ A D G P ++ A V + ++DVN+ P F+
Sbjct: 528 GIITTAASLDYELEPQPQLIVVATDGGLPPLASS------ATVSVALQDVNDNEPQFQRT 581
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEI-----VTTDVPFAID-RNGNIR 216
Y A + EG + LQV A D D P + +Y + + PF ID +G++
Sbjct: 582 FYNASLPEGTQPGTCFLQVTATDADSGP--FGLLSYSLGAGLGSSGSPPFRIDAHSGDVC 639
Query: 217 NTEKLSYDK-QHQYEILVTAYDCG 239
T L D+ ++ VTA D G
Sbjct: 640 TTRTLDRDQGPSSFDFTVTAVDGG 663
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/138 (27%), Positives = 61/138 (44%), Gaps = 12/138 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L P+D E +Y + A D G P +S V + V DVN+ P F
Sbjct: 2552 GCLVLLEPLDFESLTQYNLTVAAADRGQPP------QSSVVPVTVTVLDVNDNPPVFTRA 2605
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP--FAIDR-NGNIRNTE 219
+Y+ V E + +L VEA D D P + + + + D F +D +G +R
Sbjct: 2606 SYRVTVPEDTPVGAELLHVEASDADPGPH--GLVRFTVSSGDPSGLFELDESSGTLRLAH 2663
Query: 220 KLSYDKQHQYEILVTAYD 237
L + Q +++++V A D
Sbjct: 2664 ALDCETQARHQLVVQAAD 2681
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 13/120 (10%)
Query: 93 EAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKD 152
EA LN ++GE LRA+ P D E + + ++ A D G S V + V
Sbjct: 2756 EAFALNSSTGE--LRARVPFDYEHTESFRLLVGAADAG--------NLSASVTVSVLVTG 2805
Query: 153 VNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR 211
+E+ P F PA+ V EG + S+ V+A DED + Y + T+ F I++
Sbjct: 2806 EDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGA--DGLVLYSLATSSPYFGINQ 2863
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 14/166 (8%)
Query: 91 PFEAVVLNKTSGE-GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQ 149
P A VL+ SGE G +R P+D E++ + I+A D G P +A ++ +
Sbjct: 1794 PSGAFVLDLASGEFGTMR---PLDREVEPAFQLRIEARD-GGQPALSA-----TLLLTVT 1844
Query: 150 VKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFA 208
V D N+ AP F PAY V E + +LQ++A D D + Y T F
Sbjct: 1845 VLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN-GHVTYYLGAGTAGAFL 1903
Query: 209 ID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
++ +G +R L ++ Y V+A D G T V V +
Sbjct: 1904 LEPSSGELRTAAALDREQCPSYTFSVSAVD-GAAAGPLSTTVSVTI 1948
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/149 (26%), Positives = 61/149 (40%), Gaps = 12/149 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L +D E Q+E + A D G+ P T V + V+D N+ APTF
Sbjct: 1701 GVLTTLRALDREEQEEINLTVYAQDRGSPPQLT------HVTVRVAVEDENDHAPTFGSA 1754
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAID-RNGNIRNTEK 220
V EG+ ++ + A D D Y I+ D F +D +G
Sbjct: 1755 HLSLEVPEGQDPQTLTMLRASDPDVGANGQ--LQYRILDGDPSGAFVLDLASGEFGTMRP 1812
Query: 221 LSYDKQHQYEILVTAYDCGQKPAAQDTLV 249
L + + +++ + A D GQ PA TL+
Sbjct: 1813 LDREVEPAFQLRIEARDGGQ-PALSATLL 1840
Score = 38.9 bits (89), Expect = 0.023
Identities = 54/251 (21%), Positives = 97/251 (38%), Gaps = 31/251 (12%)
Query: 22 GGGGDSRQRRLLAAK---VNKHKPWIETS-YHGVITENNDTVILDPPLVALDKDAPVPFA 77
GG R + LL +N H P S YH V++E+ P L DA
Sbjct: 230 GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSES--LAPGSPVLQVFASDADAGVN 287
Query: 78 GEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETA 137
G + ++I+ ++ + + + G L+ + P+D E ++ + ++QA D GA P
Sbjct: 288 GAV-TYEINRRQSEGDGP-FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP---- 341
Query: 138 WKKSHKAVVHIQVKDVNEFAPTFK--------EPAYKAVVTEGKIYDSILQVEAIDEDCS 189
+ A V + V+D N+ P+ P G++ I + D D +
Sbjct: 342 --ELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFA 399
Query: 190 PQYSQICNYEIVTTDVPFAIDRNGNIRN----TEKLSYDKQHQYEILVTAYDCGQKPAAQ 245
N + + FA+ ++ +L +++ Y + VTA D G P
Sbjct: 400 H-----VNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRA 454
Query: 246 DTLVQVDVKPV 256
+ + V V
Sbjct: 455 EAAFVLHVTDV 465
Score = 38.9 bits (89), Expect = 0.023
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 27/157 (17%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYK----- 166
+D E + Y + A D G+ P +A + V DVN+ AP F Y+
Sbjct: 430 LDREERDAYNLRVTATDSGSPPLRA------EAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483
Query: 167 AVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP------FAID-RNGNIRNTE 219
V G +++V A D D Q N ++ + P F+ID +G I
Sbjct: 484 EVALPGSF---VVRVTARDPD------QGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAA 534
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
L Y+ + Q +++V A D G P A V V ++ V
Sbjct: 535 SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV 571
Score = 38.5 bits (88), Expect = 0.030
Identities = 28/68 (41%), Positives = 35/68 (51%), Gaps = 9/68 (13%)
Query: 94 AVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYD-CGAGPHETAWKKSHKAVVHIQVKD 152
A +L +SGE LR + +D E YTF + A D AGP T V I V+D
Sbjct: 1901 AFLLEPSSGE--LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT------VSVTITVRD 1952
Query: 153 VNEFAPTF 160
VN+ APTF
Sbjct: 1953 VNDHAPTF 1960
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/181 (20%), Positives = 70/181 (38%), Gaps = 27/181 (14%)
Query: 82 AFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKS 141
AF+IH Q G + +D E Q Y ++Q D G+ P T
Sbjct: 1153 AFRIHPQT--------------GEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTT---- 1194
Query: 142 HKAVVHIQVKDVNEFAPTFKEPAYKA-----VVTEGKIYDSIL--QVEAIDEDCSPQYSQ 194
VH+ V D+N+ +PTF + + A + ++ L ++A D D +
Sbjct: 1195 --GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI 1252
Query: 195 ICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ +++ +G + L ++ Y + ++A+D G P + + V V
Sbjct: 1253 LYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL 1312
Query: 255 P 255
P
Sbjct: 1313 P 1313
Score = 36.2 bits (82), Expect = 0.15
Identities = 56/245 (22%), Positives = 98/245 (40%), Gaps = 21/245 (8%)
Query: 20 GSGGGGDSRQRRLLAAKV-----NKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAP 73
G GG G RLL +V N+H P + + EN + A D D P
Sbjct: 1411 GPGGAG----ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP 1466
Query: 74 VPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGP 133
P + +++ QE P A+ L+ +G L A +D E +++A D P
Sbjct: 1467 GPNSD--VRYRLLRQEPPVPALRLDARTGA--LSAPRGLDRETTPALLLLVEATD---RP 1519
Query: 134 HETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYS 193
+ +++ + + V D N+ AP F P+ + + + L V A D D +
Sbjct: 1520 ANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGE--A 1577
Query: 194 QICNYEIVT-TDVPFAI-DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
+Y + + D F + G + L +++ ++ + V A D G P + ++ V
Sbjct: 1578 ARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTV 1637
Query: 252 DVKPV 256
V V
Sbjct: 1638 SVADV 1642
Score = 36.2 bits (82), Expect = 0.15
Identities = 34/151 (22%), Positives = 64/151 (42%), Gaps = 9/151 (5%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + + +D E+ E ++ A D G+ + A + + V D N+ PT +P
Sbjct: 2227 GTITTTAILDREIWAETRLVLMATDRGSPALVGS------ATLTVMVIDTNDNRPTIPQP 2280
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGNIRNTEKLS 222
V + + I QV D D P + + PF++ R G + T L
Sbjct: 2281 WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPS--GPQDPFSVGRYGGRVSLTGPLD 2338
Query: 223 YDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+++ +Y++ + A+D + A T++ DV
Sbjct: 2339 FEQCDRYQLQLLAHDGPHEGRANLTVLVEDV 2369
Score = 34.3 bits (77), Expect = 0.57
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 10/92 (10%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
+ ++G +R+ +D E+ ++QA GA V+ + ++D N+
Sbjct: 2117 IQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAF---------TVLTLTLQDANDN 2167
Query: 157 APTFKEPAYKAVVTEGK-IYDSILQVEAIDED 187
AP F P Y A + E + + +LQVEA D D
Sbjct: 2168 APRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/159 (28%), Positives = 75/159 (47%), Gaps = 14/159 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
GR+ P+D E+ +T + G + +I++ DVN+ AP F E
Sbjct: 114 GRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDT-----SLIFNIRISDVNDHAPQFPEK 168
Query: 164 AYKAVVTEGKIYDS-ILQVEAID--EDCSPQYSQICNYEIVTTDV----PFAIDR-NGNI 215
+ V E + I Q+ A+D E+ +P SQ+ + I T + F +DR +G I
Sbjct: 169 EFNITVQENQSAGQPIFQMLAVDLDEENTPN-SQVLYFLISQTPLLKESGFRVDRLSGEI 227
Query: 216 RNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
R + L Y+ Q+ +L+ A DCG+ + T V VDV+
Sbjct: 228 RLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQ 266
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 10/153 (6%)
Query: 37 VNKHKPWI-ETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN H P E ++ + EN ++A+D D ++ F I L E+
Sbjct: 158 VNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESG 217
Query: 96 V-LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVN 154
+++ SGE +R +D E ++T +I+A DCG S VH+ V++ N
Sbjct: 218 FRVDRLSGE--IRLSGCLDYETAPQFTLLIRARDCGEP------SLSSTTTVHVDVQEGN 269
Query: 155 EFAPTFKEPAYKAVVTEGKIYDSILQVEAIDED 187
P F + YK + EG+ +L++ D D
Sbjct: 270 NHRPAFTQENYKVQIPEGRASQGVLRLLVQDRD 302
Score = 41.6 bits (96), Expect = 0.004
Identities = 50/191 (26%), Positives = 80/191 (41%), Gaps = 20/191 (10%)
Query: 65 LVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFII 124
L+ D+D+P A +HG E + + + EG L P+D E + + II
Sbjct: 296 LLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLII 355
Query: 125 QAYD------CGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSI 178
+ C G + K + A V +QV D N+ P F ++ EG ++
Sbjct: 356 VVENEERLVFCERGKLQPPRKAAASATVSVQVTDAND-PPAFHPQSFIVNKEEGARPGTL 414
Query: 179 L-QVEAIDEDCSPQYSQICNYEIVTTDVPF-AIDRN-GNIRNTEKLSYDKQHQ----YEI 231
L A+D D SQI YE+V + ++D+N G + E + + H Y I
Sbjct: 415 LGTFNAMDPD-----SQI-RYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVI 468
Query: 232 LVTAYDCGQKP 242
++ A D G P
Sbjct: 469 IIHAVDDGFPP 479
>gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 58.9 bits (141), Expect = 2e-08
Identities = 43/151 (28%), Positives = 72/151 (47%), Gaps = 14/151 (9%)
Query: 96 VLNKTSGEG----RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVK 151
++NK +G + K+P+D E QK Y + A D GA P S A +H+ V
Sbjct: 180 LINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPP------LSSTAQIHVLVT 233
Query: 152 DVNEFAPTFKEPAYKAVVTEGKIY--DSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
D N+ AP F + Y+ ++E +Y ++LQV A D+D ++ + F +
Sbjct: 234 DANDNAPVFSQDVYRVSLSE-NVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL 292
Query: 210 DRN-GNIRNTEKLSYDKQHQYEILVTAYDCG 239
+ N G I L +++ +Y I++ A D G
Sbjct: 293 NSNTGEITVLNTLDFEEVKEYSIVLEARDGG 323
Score = 43.5 bits (101), Expect = 0.001
Identities = 41/163 (25%), Positives = 70/163 (42%), Gaps = 20/163 (12%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAP-T 159
S G + + +D E KEY+ +++A D G + V ++V D N+ AP
Sbjct: 294 SNTGEITVLNTLDFEEVKEYSIVLEARDGGG--------MIAQCTVEVEVIDENDNAPEV 345
Query: 160 FKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTE 219
+ ++ + ++ I ++ D+D C E DVPF I + RNT
Sbjct: 346 IFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLE---GDVPFKILTSS--RNTY 400
Query: 220 KLSYD------KQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
KL D + +Y I VTA D G+ P + + + + + V
Sbjct: 401 KLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDV 443
Score = 40.0 bits (92), Expect = 0.010
Identities = 38/129 (29%), Positives = 61/129 (47%), Gaps = 13/129 (10%)
Query: 78 GEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETA 137
GE+ K+ G ++PF+ +L + +L + +D E EY + A D G P
Sbjct: 378 GEVTC-KLEG-DVPFK--ILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPP---- 429
Query: 138 WKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQIC 196
S + + + + DVN+ AP F + +Y V E SI QV A D D P Q+
Sbjct: 430 --LSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN-GQV- 485
Query: 197 NYEIVTTDV 205
+Y I+ +D+
Sbjct: 486 SYCIMASDL 494
Score = 31.2 bits (69), Expect = 4.8
Identities = 24/114 (21%), Positives = 51/114 (44%), Gaps = 10/114 (8%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTD 204
V+++++D+N+ P F + +++ ++E + + A D D Q NY++ +D
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQ--NYQLSPSD 176
Query: 205 VPFAIDRNGNIRN-------TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
I++ + + L +KQ Y + +TA D G P + + V
Sbjct: 177 HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHV 230
>gi|13470082 protocadherin gamma subfamily B, 4 isoform 1 precursor
[Homo sapiens]
Length = 923
Score = 58.9 bits (141), Expect = 2e-08
Identities = 43/151 (28%), Positives = 72/151 (47%), Gaps = 14/151 (9%)
Query: 96 VLNKTSGEG----RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVK 151
++NK +G + K+P+D E QK Y + A D GA P S A +H+ V
Sbjct: 180 LINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPP------LSSTAQIHVLVT 233
Query: 152 DVNEFAPTFKEPAYKAVVTEGKIY--DSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI 209
D N+ AP F + Y+ ++E +Y ++LQV A D+D ++ + F +
Sbjct: 234 DANDNAPVFSQDVYRVSLSE-NVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL 292
Query: 210 DRN-GNIRNTEKLSYDKQHQYEILVTAYDCG 239
+ N G I L +++ +Y I++ A D G
Sbjct: 293 NSNTGEITVLNTLDFEEVKEYSIVLEARDGG 323
Score = 43.5 bits (101), Expect = 0.001
Identities = 41/163 (25%), Positives = 70/163 (42%), Gaps = 20/163 (12%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAP-T 159
S G + + +D E KEY+ +++A D G + V ++V D N+ AP
Sbjct: 294 SNTGEITVLNTLDFEEVKEYSIVLEARDGGG--------MIAQCTVEVEVIDENDNAPEV 345
Query: 160 FKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTE 219
+ ++ + ++ I ++ D+D C E DVPF I + RNT
Sbjct: 346 IFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLE---GDVPFKILTSS--RNTY 400
Query: 220 KLSYD------KQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
KL D + +Y I VTA D G+ P + + + + + V
Sbjct: 401 KLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDV 443
Score = 40.0 bits (92), Expect = 0.010
Identities = 38/129 (29%), Positives = 61/129 (47%), Gaps = 13/129 (10%)
Query: 78 GEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETA 137
GE+ K+ G ++PF+ +L + +L + +D E EY + A D G P
Sbjct: 378 GEVTC-KLEG-DVPFK--ILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPP---- 429
Query: 138 WKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQIC 196
S + + + + DVN+ AP F + +Y V E SI QV A D D P Q+
Sbjct: 430 --LSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN-GQV- 485
Query: 197 NYEIVTTDV 205
+Y I+ +D+
Sbjct: 486 SYCIMASDL 494
Score = 31.2 bits (69), Expect = 4.8
Identities = 24/114 (21%), Positives = 51/114 (44%), Gaps = 10/114 (8%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTD 204
V+++++D+N+ P F + +++ ++E + + A D D Q NY++ +D
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQ--NYQLSPSD 176
Query: 205 VPFAIDRNGNIRN-------TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
I++ + + L +KQ Y + +TA D G P + + V
Sbjct: 177 HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHV 230
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 57.0 bits (136), Expect = 8e-08
Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 11/153 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G++ P+D E ++Y I+A D G P + K + I V DVN+ AP FKE
Sbjct: 2619 GQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEK------LDITVLDVNDNAPIFKED 2672
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAIDR-NGNIRNTEK 220
+ + + E IL V A+D+D P +YEIV ++ F+I+ G IR+
Sbjct: 2673 PFISEILENLSPRKILTVSAMDKDSGPNGQ--LDYEIVNGNMENSFSINHATGEIRSVRP 2730
Query: 221 LSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
L +K Y + + + D G + V +++
Sbjct: 2731 LDREKVSHYVLTIKSSDKGSPSQSTSVKVMINI 2763
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/144 (29%), Positives = 65/144 (45%), Gaps = 13/144 (9%)
Query: 101 SGEG---RLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFA 157
SGEG L +K +D E+ +Y +++ D G K+ V++ V+D+N+
Sbjct: 194 SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEP------KRRGYLQVNVTVQDINDNP 247
Query: 158 PTFKEPAYKAVVTEGKIY-DSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNI 215
P F Y+A V E + S+LQV A D D Y + PF +D G I
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNAD--IRYRLQDEGTPFQMDPETGLI 305
Query: 216 RNTEKLSYDKQHQYEILVTAYDCG 239
E L ++ + QY + V A D G
Sbjct: 306 TVREPLDFEARRQYSLTVQAMDRG 329
Score = 52.4 bits (124), Expect = 2e-06
Identities = 40/146 (27%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + P+D E Y +QA D G+ P ++ + V I + D+N+F P F+
Sbjct: 2209 GAITVAKPLDREKTPTYHLTVQATDRGSTP------RTDTSTVSIVLLDINDFVPVFELS 2262
Query: 164 AYKAVVTE--GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKL 221
Y V E G + +ILQV A D+D D F + +G + T+ L
Sbjct: 2263 PYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSL 2322
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDT 247
+ + ++ +++TA D G PA T
Sbjct: 2323 DRETKERFVLMITATDSG-SPALTGT 2347
Score = 52.4 bits (124), Expect = 2e-06
Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 9/151 (5%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G +R+ P+D E Y I++ D G+ T+ K V I + D N+ AP F +
Sbjct: 2723 GEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVK------VMINILDENDNAPRFSQI 2776
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRN-GNIRNTEKLS 222
V + ++ +V DED + I Y I+ +PF I+ + G+I + L+
Sbjct: 2777 FSAHVPENSPLGYTVTRVTTSDEDIG--INAISRYSIMDASLPFTINPSTGDIVISRPLN 2834
Query: 223 YDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ +Y I V+A+D G + T+ D+
Sbjct: 2835 REDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865
Score = 51.2 bits (121), Expect = 5e-06
Identities = 42/160 (26%), Positives = 72/160 (45%), Gaps = 10/160 (6%)
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEF 156
++ TSG+ L K +D E Y+ +IQA D G P + ++I + D N+
Sbjct: 1260 IDSTSGQVTLIGK--LDYEATPAYSLVIQAVDSGTIPLNST------CTLNIDILDENDN 1311
Query: 157 APTF-KEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRN-GN 214
P+F K + V+ +I + + V A D D + F+I N G+
Sbjct: 1312 TPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS 1371
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
I +KL ++ Q Y++ +TA D G+ P + V + V+
Sbjct: 1372 IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/115 (28%), Positives = 58/115 (50%), Gaps = 6/115 (5%)
Query: 143 KAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKI-YDSILQVEAIDEDCSPQYSQICNYEIV 201
+A VH+ +KD+N+ AP F + Y+A ++E +L+V A D D + + +Y I+
Sbjct: 1193 QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVD--EGNNGLIHYSII 1250
Query: 202 --TTDVPFAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ FAID +G + KL Y+ Y +++ A D G P + +D+
Sbjct: 1251 KGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDI 1305
Score = 49.3 bits (116), Expect = 2e-05
Identities = 77/305 (25%), Positives = 118/305 (38%), Gaps = 44/305 (14%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTF 160
S G L +D E ++ + +I A D G+ P T +++ V DVN+ PTF
Sbjct: 2311 SASGELGVTQSLDRETKERFVLMITATDSGS-PALTG-----TGTINVIVDDVNDNVPTF 2364
Query: 161 KEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNIRNT 218
AY + E +L V A D D S I+ + F I+ G I +
Sbjct: 2365 ASKAYFTTIPEDAPTGTDVLLVNASDADASKN----AVIRIIGGNSQFTINPSTGQIITS 2420
Query: 219 EKLSYDKQHQYEILVTAYDCGQ-KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSM 277
L + + Y ++V D G +P + T V V V V D R ++ P +
Sbjct: 2421 ALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDV-----NDNPPRFQHHPYVTHI 2475
Query: 278 PLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSP 337
P T G+ VT+ IG + YS L G +S + P
Sbjct: 2476 P------SPTLPGSFVFAVTVTDAD---IGPNSELH-YS------LSGRNSEKFHIDPLR 2519
Query: 338 SAATNWTAGLLVDSSEMIFKFDGRQGAKVPDGIVPKNLTDQFTITM-WMKHGPSPGVRAE 396
A AG L +SE+ F + G P TD T+T+ ++ P VRA+
Sbjct: 2520 GAI--MAAGPLNGASEVTFSVHVKDGGSFPK-------TDSTTVTVRFVNKADFPKVRAK 2570
Query: 397 KETIL 401
++T +
Sbjct: 2571 EQTFM 2575
Score = 48.1 bits (113), Expect = 4e-05
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 7/152 (4%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L+ +D E Q Y ++Q +D P A + + A V I + DVN+ PTF P
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHDL---PQIPASRFTSTAQVSIILLDVNDNPPTFLSP 2054
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVT-TDVPFAIDR-NGNIRNTEKL 221
+ I + + +A D D P + Y ++ F+I +G +R T +L
Sbjct: 2055 KLTYIPENTPIDTVVFKAQATDPDSGP--NSYIEYTLLNPLGNKFSIGTIDGEVRLTGEL 2112
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
++ Y + V A D GQ + T V V V
Sbjct: 2113 DREEVSNYTLTVVATDKGQPSLSSSTEVVVMV 2144
Score = 46.2 bits (108), Expect = 1e-04
Identities = 60/241 (24%), Positives = 91/241 (37%), Gaps = 34/241 (14%)
Query: 55 NNDTVILDPPLVALDKDAPVPFAGEICAFKIH------GQELPFEAVVLNKTSG------ 102
+N L P L + ++ P+ + FK G E +LN
Sbjct: 2046 DNPPTFLSPKLTYIPENTPI----DTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGT 2101
Query: 103 -EGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFK 161
+G +R +D E YT + A D G S V + V D+N+ P F
Sbjct: 2102 IDGEVRLTGELDREEVSNYTLTVVATDKGQP------SLSSSTEVVVMVLDINDNNPIFA 2155
Query: 162 EPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIV--TTDVPFAIDR-NGNIRN 217
+ YK + E + + I+QV A D D Q+ Y IV T+ F ID G I
Sbjct: 2156 QALYKVEINENTLTGTDIIQVFAADGD-EGTNGQV-RYGIVNGNTNQEFRIDSVTGAITV 2213
Query: 218 TEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSM 277
+ L +K Y + V A D G P + V + + + D+ E P S ++
Sbjct: 2214 AKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDI-----NDFVPVFELSPYSVNV 2268
Query: 278 P 278
P
Sbjct: 2269 P 2269
Score = 44.3 bits (103), Expect = 6e-04
Identities = 37/138 (26%), Positives = 63/138 (45%), Gaps = 11/138 (7%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTE 171
+D E+Q+ Y ++A D G G T V+ + DVN+ P F +Y + E
Sbjct: 1904 LDYEVQQYYILTVRAED-GGGQFTTIR-------VYFNILDVNDNPPIFSLNSYSTSLME 1955
Query: 172 GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAIDRNGNIRNTEKLSYDKQHQY 229
S + V + + SQ+ Y I + D F +D+NG ++ + L + Q Y
Sbjct: 1956 NLPVGSTVLVFNVTDADDGINSQL-TYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFY 2014
Query: 230 EILVTAYDCGQKPAAQDT 247
++V +D Q PA++ T
Sbjct: 2015 NLVVQVHDLPQIPASRFT 2032
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 11/153 (7%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
GRL S +D E Q Y+ ++ A D G+ P +S A +++ + D+N+ +P F
Sbjct: 639 GRLSTISSLDREEQAFYSLLVLATDLGSPP------QSSMARINVSLLDINDNSPVFYPV 692
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTD-VPFAID-RNGNIRNTEK 220
Y A + E + S I V A D D + Y I D F ++ ++G I
Sbjct: 693 QYFAHIKENEPGGSYITTVSATDPDLGT--NGTVKYSISAGDRSRFQVNAQSGVISTRMA 750
Query: 221 LSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
L +++ Y++ + A D G + +V + V
Sbjct: 751 LDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/164 (27%), Positives = 74/164 (45%), Gaps = 16/164 (9%)
Query: 87 GQELPFEAVVLN-----KTSGE----GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETA 137
G E P E +++ KT G GR L +E + D A TA
Sbjct: 1658 GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTA 1717
Query: 138 WKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYD--SILQVEAIDEDCSPQYSQI 195
+ ++ +A V I ++D+N+ P F V E I D I+Q+ A+D D + +
Sbjct: 1718 FPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEE-NIGDGSKIMQLTAMDAD--EGANAL 1774
Query: 196 CNYEIVT-TDVPFAID-RNGNIRNTEKLSYDKQHQYEILVTAYD 237
Y I++ D F ID +G++ T +L +++ +Y +LV A D
Sbjct: 1775 VTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 17/163 (10%)
Query: 103 EGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
+G+L KS +D ELQ Y ++ A D P S V + ++DVN+ P F
Sbjct: 1049 DGQLYIKSELDRELQDRYVLMVVASDRAVEP------LSATVNVTVILEDVNDNRPLFNS 1102
Query: 163 PAYKAVVTEGKIYDSIL-QVEAIDEDCSPQYSQICNYEIVTTDVPF-AIDRNGNIRNTEK 220
Y E + S + +V A+D+D P ++E+V D AI +G I NT +
Sbjct: 1103 TNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAI--SGEITNTHQ 1160
Query: 221 LSYDKQHQ------YEILVTAYDCG-QKPAAQDTLVQVDVKPV 256
+ + + V A D G +P V V +K +
Sbjct: 1161 FDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDI 1203
Score = 39.3 bits (90), Expect = 0.018
Identities = 28/117 (23%), Positives = 54/117 (46%), Gaps = 1/117 (0%)
Query: 141 SHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYE 199
S ++ + V DVN+ +P F + +Y+ ++E + +S +V+A D+D
Sbjct: 977 SSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIA 1036
Query: 200 IVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
T F I +G + +L + Q +Y ++V A D +P + V V ++ V
Sbjct: 1037 EGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDV 1093
Score = 39.3 bits (90), Expect = 0.018
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 15/140 (10%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L A +D E + +Y+ +++A D +S ++I V DVN+ P F P
Sbjct: 1794 GDLIATRRLDRERRSKYSLLVRADD---------GLQSSDMRINITVSDVNDHTPKFSRP 1844
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTD----VPFAIDRNGNIRNTE 219
Y + E I S++ +D S +I IV D + F G T
Sbjct: 1845 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEIT--YIVNEDDEDGIFFLNPITGVFNLTR 1902
Query: 220 KLSYDKQHQYEILVTAYDCG 239
L Y+ Q Y + V A D G
Sbjct: 1903 LLDYEVQQYYILTVRAEDGG 1922
Score = 38.9 bits (89), Expect = 0.023
Identities = 34/136 (25%), Positives = 54/136 (39%), Gaps = 2/136 (1%)
Query: 37 VNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVV 96
V K + + TS + + EN + L D D+P G I + G E V
Sbjct: 352 VVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA-NGNISVQILGGNEQRHFEVQ 410
Query: 97 LNKTSGEGRLRAKSPIDCELQKEYTFIIQAYD-CGAGPHETAWKKSHKAVVHIQVKDVNE 155
+K ++ S +D E Y + D GA P +S A + I V D+N+
Sbjct: 411 SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 156 FAPTFKEPAYKAVVTE 171
P F + Y+ ++E
Sbjct: 471 HPPVFSQQVYRVNLSE 486
Score = 37.7 bits (86), Expect = 0.052
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + S + +L + + + A D G P S +A VHI V + N P F +
Sbjct: 3039 GWISVASSLISDLNQNFFITVTAKDKGNPP------LSSQATVHITVTEENYHTPEFSQS 3092
Query: 164 AYKAVVTEGKIYDSILQ-VEAIDEDCSPQYSQICNYEIVTTDVP--FAIDRNGNIRNTEK 220
A + E SI++ V A D D + + + Y I + + FAI+ + I K
Sbjct: 3093 HMSATIPESHSIGSIVRTVSARDRDAA--MNGLIKYSISSGNEEGIFAINSSTGILTLAK 3150
Query: 221 -LSYDKQHQYEILVTAYDCG 239
L Y+ ++E+ ++A D G
Sbjct: 3151 ALDYELCQKHEMTISAIDGG 3170
Score = 37.4 bits (85), Expect = 0.067
Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 13/158 (8%)
Query: 101 SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAW-KKSHKAVVHIQVKDVNEFAPT 159
S G L +D EL +++ I A D G W ++ V + V DVN+ +P
Sbjct: 3141 SSTGILTLAKALDYELCQKHEMTISAIDGG-------WVARTGYCSVTVNVIDVNDNSPV 3193
Query: 160 FKEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-FAIDRNGNIRN 217
F Y V E +++ + A D D + + Y + ++D F ID N +
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADSGT--NAVIAYTVQSSDSDLFVIDPNTGVIT 3251
Query: 218 TEK-LSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
T+ L ++ + Y + V A++ + V + +K
Sbjct: 3252 TQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLK 3289
Score = 36.2 bits (82), Expect = 0.15
Identities = 53/226 (23%), Positives = 89/226 (39%), Gaps = 29/226 (12%)
Query: 38 NKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVL 97
N + P + + EN+ + D+D + I + I LPF +
Sbjct: 2767 NDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGI---NAISRYSIMDASLPF---TI 2820
Query: 98 NKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFA 157
N ++G+ + P++ E Y + A+D G W S V I V D+N+ A
Sbjct: 2821 NPSTGD--IVISRPLNREDTDRYRIRVSAHDSG-------WTVSTD--VTIFVTDINDNA 2869
Query: 158 PTFKEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAID-RNGNI 215
P F +Y E +I + QV A D D Q+ Y I + F I+ G I
Sbjct: 2870 PRFSRTSYYLDCPELTEIGSKVTQVFATDPD-EGSNGQVF-YFIKSQSEYFRINATTGEI 2927
Query: 216 RNTEKLSYDKQ--------HQYEILVTAYDCGQKPAAQDTLVQVDV 253
N + L Y +++ +VT+ D G+ +T V +++
Sbjct: 2928 FNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973
Score = 32.7 bits (73), Expect = 1.7
Identities = 31/128 (24%), Positives = 59/128 (46%), Gaps = 21/128 (16%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + + P+D E +++Y+ +QA D G P T +A IQ+ DVN+ P
Sbjct: 303 GLITVREPLDFEARRQYSLTVQAMDRGV-PSLTG-----RAEALIQLLDVNDNDP----- 351
Query: 164 AYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSY 223
V + + + + + ++DE+ + + + D P A NGNI + + L
Sbjct: 352 -----VVKFRYFPATSRYASVDENAQVG-TVVALLTVTDADSPAA---NGNI-SVQILGG 401
Query: 224 DKQHQYEI 231
++Q +E+
Sbjct: 402 NEQRHFEV 409
Score = 32.7 bits (73), Expect = 1.7
Identities = 41/155 (26%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + + +D E + Y I A D G + ++A+V I V D + P F +
Sbjct: 743 GVISTRMALDREEKTAYQLQIVATDGGN------LQSPNQAIVTITVLDTQDNPPVFSQV 796
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP--FAIDR-NGNIRNTE 219
AY VV E + + V A D + S Y I T D FAI++ G +
Sbjct: 797 AYSFVVFENVALGYHVGSVSASTMDLNSNIS----YLITTGDQKGMFAINQVTGQLTTAN 852
Query: 220 KLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
+ ++Q Y++ V A DT+V + VK
Sbjct: 853 VIDREEQSFYQLKVVA---SGGTVTGDTMVNITVK 884
Score = 31.6 bits (70), Expect = 3.7
Identities = 35/153 (22%), Positives = 65/153 (42%), Gaps = 15/153 (9%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
VN + P ++ Y + EN + L A D D+ + A+ + + +
Sbjct: 3187 VNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGT---NAVIAYTVQSSDSDLFVI 3243
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
N G + + +D E ++ Y ++A++ P E ++ A V+IQ+K NE
Sbjct: 3244 DPNT----GVITTQGFLDFETKQSYHLTVKAFNV---PDE---ERCSFATVNIQLKGTNE 3293
Query: 156 FAPTFKEPAYKAVVTEGKIYDSIL-QVEAIDED 187
+ P F Y ++E +I+ +V A D D
Sbjct: 3294 YVPRFVSKLYYFEISEAAPKGTIVGEVFASDRD 3326
>gi|9256606 protocadherin beta 12 precursor [Homo sapiens]
Length = 795
Score = 57.0 bits (136), Expect = 8e-08
Identities = 60/234 (25%), Positives = 98/234 (41%), Gaps = 22/234 (9%)
Query: 11 LLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGV-ITENNDTVILDPPLVALD 69
+L AL GS G + R++ +N + P E +++ V I EN+ L + A D
Sbjct: 211 ILTALDGGSPPRSG--TALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWD 268
Query: 70 KDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDC 129
D+ E+ H E + +N+ SG+ L A P+D E + Y+ IIQA D
Sbjct: 269 LDSGTN--SELSYTFSHASEDIRKTFEINQKSGDITLTA--PLDFEAIESYSIIIQATDG 324
Query: 130 GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCS 189
G K+ V IQV DVN+ AP + + + E ++ D D
Sbjct: 325 GG--------LFGKSTVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSG 376
Query: 190 PQYSQICNYEIVTTDVPFAIDRNGN----IRNTEKLSYDKQHQYEILVTAYDCG 239
+C+ + D+PF + + N + L + + +Y I +T D G
Sbjct: 377 DNGKMVCS---IPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNITITVTDLG 427
Score = 50.1 bits (118), Expect = 1e-05
Identities = 37/132 (28%), Positives = 65/132 (49%), Gaps = 10/132 (7%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTE 171
+D E + E +FI+ A D G+ P +S A+V + V D+N+ +P F++ Y+ + E
Sbjct: 200 LDYEERPELSFILTALDGGSPP------RSGTALVRVVVVDINDNSPEFEQAFYEVKILE 253
Query: 172 GKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDV--PFAID-RNGNIRNTEKLSYDKQH 227
I S ++ V A D D + + D+ F I+ ++G+I T L ++
Sbjct: 254 NSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIE 313
Query: 228 QYEILVTAYDCG 239
Y I++ A D G
Sbjct: 314 SYSIIIQATDGG 325
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 19/173 (10%)
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
+++PF V+ + + L + P+D E + EY I D G K H +
Sbjct: 387 EDIPF--VLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGT----PRLKTEHN--IT 438
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTDVP 206
+ V DVN+ AP F + +Y V E I + A D D S +Q+ NY ++ + P
Sbjct: 439 VLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRD-SGTNAQV-NYSLLPSQDP 496
Query: 207 -------FAIDR-NGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
+I+ NG++ L Y+ ++ V A D G + + LV+V
Sbjct: 497 HLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRV 549
Score = 33.9 bits (76), Expect = 0.75
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEI-VTTD 204
+ +QV+D+N+ +P F E + E ++ +E+ +D + + +Y I +
Sbjct: 119 IELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESA-KDLDVGINAVKSYTINPNSH 177
Query: 205 VPFAIDRNGNIRNTEKLSYDKQHQYE------ILVTAYDCGQKPAAQDTLVQVDV 253
I N + R +L DK YE ++TA D G P + LV+V V
Sbjct: 178 FHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVV 232
>gi|9256604 protocadherin beta 11 precursor [Homo sapiens]
Length = 797
Score = 56.6 bits (135), Expect = 1e-07
Identities = 63/234 (26%), Positives = 99/234 (42%), Gaps = 22/234 (9%)
Query: 11 LLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGV-ITENNDTVILDPPLVALD 69
+L AL GS G + R++ +N + P E +++ V I EN+ L + A D
Sbjct: 211 ILSALDGGSPPRSG--TALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWD 268
Query: 70 KDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDC 129
D+ GEIC H E + +N+ SGE LRA P+D E + Y+ IIQA D
Sbjct: 269 LDSGTN--GEICYTFSHASEDIRKTFEINQKSGEITLRA--PLDFETIESYSIIIQATDG 324
Query: 130 GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCS 189
G K+ V I V DVN+ AP + + + E ++ D D
Sbjct: 325 GG--------LFGKSTVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSG 376
Query: 190 PQYSQICNYEIVTTDVPF----AIDRNGNIRNTEKLSYDKQHQYEILVTAYDCG 239
+C+ + D+PF +++ + L + +Y I +T D G
Sbjct: 377 DNGRIVCS---IPEDLPFVLKSSVENYYTLETERPLDRESTAEYNITITVTDLG 427
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/133 (30%), Positives = 66/133 (49%), Gaps = 12/133 (9%)
Query: 112 IDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTE 171
+D E E +FI+ A D G+ P +S A+V + V D+N+ +P F++ Y+ + E
Sbjct: 200 LDYEELPELSFILSALDGGSPP------RSGTALVRVVVVDINDNSPEFEQAFYEVKIRE 253
Query: 172 GKIYDS-ILQVEAIDEDCSPQYSQIC-NYEIVTTDV--PFAID-RNGNIRNTEKLSYDKQ 226
I S IL V A D D S +IC + + D+ F I+ ++G I L ++
Sbjct: 254 NSILGSLILIVSAWDLD-SGTNGEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETI 312
Query: 227 HQYEILVTAYDCG 239
Y I++ A D G
Sbjct: 313 ESYSIIIQATDGG 325
Score = 43.9 bits (102), Expect = 7e-04
Identities = 49/173 (28%), Positives = 71/173 (41%), Gaps = 19/173 (10%)
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
++LPF V+ + L + P+D E EY I D G K H V
Sbjct: 387 EDLPF--VLKSSVENYYTLETERPLDRESTAEYNITITVTDLGI----PRLKTEHNTTV- 439
Query: 148 IQVKDVNEFAPTFKEPAYKAVVTEGKIYD-SILQVEAIDEDCSPQYSQICNYEIVTTD-- 204
V DVN+ APTF + +Y V E I V A D D S +Q+ NY ++
Sbjct: 440 -LVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRD-SGTNAQV-NYSLLPPQDL 496
Query: 205 -VPFAI-----DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
+P A NG++ L Y+ ++ V A D G + + LV+V
Sbjct: 497 HLPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVRV 549
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 56.2 bits (134), Expect = 1e-07
Identities = 63/228 (27%), Positives = 97/228 (42%), Gaps = 15/228 (6%)
Query: 32 LLAAKVNKHKPWIETS-YHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQEL 90
+L N H P E Y + EN + + A D DAP P A +
Sbjct: 277 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAP-PNANILYRLLEGSGGS 335
Query: 91 PFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQV 150
P E ++ SG +R + P+D E + Y ++A D G P +S A V + V
Sbjct: 336 PSEVFEIDPRSGV--IRTRGPVDREEVESYQLTVEASDQGRDPGP----RSTTAAVFLSV 389
Query: 151 KDVNEFAPTFKEPAYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDV--PF 207
+D N+ AP F E Y V E + +L+V A D D + + +Y I++ + F
Sbjct: 390 EDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGS--NAVVHYSIMSGNARGQF 447
Query: 208 AID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQ-DTLVQVDV 253
+D + G + L Y+ +Y + V A D G+ P + LV V V
Sbjct: 448 YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQV 495
Score = 54.7 bits (130), Expect = 4e-07
Identities = 48/155 (30%), Positives = 64/155 (41%), Gaps = 7/155 (4%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G L SP+D E KEYT ++A D G P +V +QV D+N+ AP F
Sbjct: 454 GALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNV-----SGLVTVQVLDINDNAPIFVST 508
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDR-NGNIRNTEKL 221
++A V E + +L V+AID D V D PF I+ G I +L
Sbjct: 509 PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAEL 568
Query: 222 SYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPV 256
++ Y V A D G V V V V
Sbjct: 569 DREEVDFYSFGVEARDHGTPALTASASVSVTVLDV 603
Score = 51.6 bits (122), Expect = 3e-06
Identities = 65/250 (26%), Positives = 99/250 (39%), Gaps = 26/250 (10%)
Query: 15 LGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENND-----TVILDPPLVALD 69
L V + G D+ Q + N H+P ++S H + N D TV+L + A D
Sbjct: 683 LAVTASDGTRQDTAQIVVNVTDANTHRPVFQSS-HYTVNVNEDRPAGTTVVL---ISATD 738
Query: 70 KDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDC 129
+D GE ++ + G + ++ +D E Q YT I A D
Sbjct: 739 EDT-----GENARITYFMED---SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDN 790
Query: 130 GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEG-KIYDSILQVEAIDEDC 188
G +KS + I V DVN+ AP F +Y+ V E + S+LQ+ A D D
Sbjct: 791 GIP------QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDS 844
Query: 189 SPQYSQICNYEIVTT-DVPFAID-RNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQD 246
++ D F ++ +G +R +L + QY + A D G PA
Sbjct: 845 GLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTP 904
Query: 247 TLVQVDVKPV 256
V V V V
Sbjct: 905 MEVTVTVLDV 914
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/216 (26%), Positives = 93/216 (43%), Gaps = 23/216 (10%)
Query: 37 VNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAV 95
+N + P ++ T + + E+ L + A+D DA E + G + PF
Sbjct: 498 INDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV-GHDFPFTI- 555
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
+G G + + +D E Y+F ++A D G P TA A V + V DVN+
Sbjct: 556 ----NNGTGWISVAAELDREEVDFYSFGVEARDHGT-PALTA-----SASVSVTVLDVND 605
Query: 156 FAPTFKEPAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVT--TDVPFAI--- 209
PTF +P Y + E + S++ V A+D D + Y+I + T F+I
Sbjct: 606 NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITSGNTRNRFSITSQ 661
Query: 210 DRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQ 245
G + L Y + QY + VTA D ++ AQ
Sbjct: 662 SGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQ 697
Score = 45.8 bits (107), Expect = 2e-04
Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 15/155 (9%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
G + +D E + + F + A D G ++S A + I V D N+ P F++
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMP------RRSALATLTILVTDTNDHDPVFEQQ 292
Query: 164 AYKAVVTEG-KIYDSILQVEAIDEDCSPQYSQICNYEIV-----TTDVPFAID-RNGNIR 216
YK + E ++ +L V A D D P + + Y ++ + F ID R+G IR
Sbjct: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANIL--YRLLEGSGGSPSEVFEIDPRSGVIR 350
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQV 251
+ ++ Y++ V A D G+ P + T V
Sbjct: 351 TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAV 385
Score = 39.3 bits (90), Expect = 0.018
Identities = 53/215 (24%), Positives = 93/215 (43%), Gaps = 18/215 (8%)
Query: 26 DSRQRRLLAAKVNKHKP-WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFK 84
D+ +L VN + P ++ SY G + E+ + A D+D+ + G +
Sbjct: 797 DTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLN--GRVFYTF 854
Query: 85 IHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKA 144
G + + +V S G +R +D E +Y A D G P T +
Sbjct: 855 QGGDDGDGDFIV---ESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPME----- 906
Query: 145 VVHIQVKDVNEFAPTFKEPAYKAVVTEGK-IYDSILQVEAIDEDCSPQYSQICNYEIVTT 203
V + V DVN+ P F++ + V E I ++ +V A D D +QI Y+IV
Sbjct: 907 -VTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPD-EGTNAQIM-YQIVEG 963
Query: 204 DVP--FAID-RNGNIRNTEKLSYDKQHQYEILVTA 235
++P F +D +G + L Y+ + +Y +++ A
Sbjct: 964 NIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
Score = 31.2 bits (69), Expect = 4.8
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 889 EKHEGPGHGEDETEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHG 937
++H+ + + E+++ + SS S++ EEEEEEE G G
Sbjct: 2712 QQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG 2760
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo
sapiens]
Length = 1955
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 447
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 448 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 496
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 712
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 713 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 769
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHP 798
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1204
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1205 KTAMLFHNMRRSY 1217
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 818 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 876
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 929
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 930 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 989
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 990 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1042
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 293 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 350
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 404
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 405 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 462
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 499
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 239
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo
sapiens]
Length = 1932
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 367 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 425
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 426 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 474
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 690
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 691 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 747
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHP 776
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1065 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1125 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1182
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1183 KTAMLFHNMRRSY 1195
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 796 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 854
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 907
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 908 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 967
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 968 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1020
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 271 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 328
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 329 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 382
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 383 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 440
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 441 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 477
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 217
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
Length = 1677
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 447
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 448 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 496
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 712
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 713 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 769
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHP 798
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1204
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1205 KTAMLFHNMRRSY 1217
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 818 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 876
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 929
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 930 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 989
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 990 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1042
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 293 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 350
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 404
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 405 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 462
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 499
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 239
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo
sapiens]
Length = 1682
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 394 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 452
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 453 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 501
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 502 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 665 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 717
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 718 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 774
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHP 803
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1092 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1151
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1152 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1209
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1210 KTAMLFHNMRRSY 1222
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 823 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 881
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 882 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 934
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 935 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 994
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 995 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1047
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 298 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 355
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 356 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 409
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 410 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 467
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 468 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 504
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 244
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo
sapiens]
Length = 1539
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 447
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 448 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 496
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 712
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 713 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 769
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHP 798
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1204
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1205 KTAMLFHNMRRSY 1217
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 818 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 876
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 929
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 930 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 989
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 990 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1042
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 293 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 350
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 404
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 405 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 462
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 499
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 239
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo
sapiens]
Length = 1790
Score = 56.2 bits (134), Expect = 1e-07
Identities = 55/164 (33%), Positives = 81/164 (49%), Gaps = 22/164 (13%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAP-VPFAGEICAF-KI 85
N P+ SY G I E+ +D++ L PL VALDKD VP +G ++
Sbjct: 394 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPEL 453
Query: 86 HGQELPFEAVVLNKTSGEGR-LRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKA 144
H + +V +G R L P+D E Q+ YTF I A+D ++S
Sbjct: 454 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPV 505
Query: 145 VVHIQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
+V+IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 506 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 672 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 724
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 725 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 781
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 782 SIYTAVKLNREVRDYYELVVVATDGAVHP 810
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1099 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1158
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1159 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1216
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1217 KTAMLFHNMRRSY 1229
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 830 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 888
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 889 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 941
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 942 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 1001
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 1002 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1054
Score = 33.9 bits (76), Expect = 0.75
Identities = 48/226 (21%), Positives = 93/226 (41%), Gaps = 38/226 (16%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 298 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 355
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 356 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 409
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC-----------SPQYSQICN-YEIVTTDVPF 207
E I DS+ L++ A+D+D P+ N Y V T
Sbjct: 410 LESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQT 469
Query: 208 AIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
I R + + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 470 GITR--YLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 511
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 244
Score = 33.5 bits (75), Expect = 0.97
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 864 QETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEEMSSSSGSDDSE 923
+ TE+ ESE ++S+ T E+ E E E E E +EEE SS+ S++SE
Sbjct: 1595 EATESTVESE---EESSSDYTEYSEEESEFSESETTEEESESETPSEEEESSTPESEESE 1651
Query: 924 EEEEE 928
E E
Sbjct: 1652 STESE 1656
Score = 32.0 bits (71), Expect = 2.8
Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 10/77 (12%)
Query: 867 EAAKESEMDWDDSALTITVNPMEKHEGPGHGEDETEGEEE---EEAEEEMSSSSGSDDSE 923
E KE +M+ ++ + E+ GP E+ T+ E + EE E +S G +SE
Sbjct: 1688 EEQKEPKMEEEEHS-------EEEESGPAPVEESTDPEAQDIPEEGSAESASVEGGVESE 1740
Query: 924 EEEEEEGMGRGRHGQNG 940
EE E Q+G
Sbjct: 1741 EESESGSSSSSSESQSG 1757
Score = 31.2 bits (69), Expect = 4.8
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 877 DDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEEMSSSSGSDDSEEEEEEE 929
D L +T++ E E E+E+ + E +EEE S S S+ +EEE E E
Sbjct: 1583 DKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEE-SEFSESETTEEESESE 1634
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo
sapiens]
Length = 1935
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/161 (32%), Positives = 77/161 (47%), Gaps = 23/161 (14%)
Query: 38 NKHKPWIET-SYHGVITEN-------NDTVILDPPL--VALDKDAPVPFAGEICAFKIHG 87
N P+ SY G I E+ +D++ L PL VALDKD E+ F ++
Sbjct: 367 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LND 425
Query: 88 QELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVH 147
F + +T L P+D E Q+ YTF I A+D ++S +V+
Sbjct: 426 YTSVF---TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--------GVQESEPVIVN 474
Query: 148 IQVKDVNEFAPTFKEPAYKA-VVTEGKIYDSILQVEAIDED 187
IQV D N+ PTF E +Y V T+ + DS++Q+ A+D D
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 12/149 (8%)
Query: 96 VLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNE 155
V N + G L +D E Y II A D P T+ A V+I V DVN+
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTS-----TATVNIVVTDVND 690
Query: 156 FAPTFKE--PAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNG 213
AP F P +VV E + + QV+A D D Q+ +Y + + F I NG
Sbjct: 691 NAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQV-HYSLGNFNNLFRITSNG 747
Query: 214 NIRNTEKLSYDKQHQYEILVTAYDCGQKP 242
+I KL+ + + YE++V A D P
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHP 776
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 104 GRLRAKSPIDCELQKEYTFIIQAYDCGAG-PHETAWKKSHKAVVHIQVKDVNEFAPTFKE 162
G + P+D E + Y +QA + KS+ A V+I+++D N P F++
Sbjct: 1065 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Query: 163 PAYKAVVTE-GKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVP-----FAIDRNGNIR 216
Y V+E +++ S+L+V+A D+D + YS + Y ++ + F ++ +
Sbjct: 1125 KFYIGGVSEDARMFTSVLRVKATDKD-TGNYS-VMAYRLIIPPIKEGKEGFVVETYTGLI 1182
Query: 217 NTEKLSYDKQHQY 229
T L ++ + Y
Sbjct: 1183 KTAMLFHNMRRSY 1195
Score = 38.5 bits (88), Expect = 0.030
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 25/236 (10%)
Query: 51 VITENNDTVILDPPLVA----LDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRL 106
V T + TV+++ L A L +A G +++I E+ L+ +GE L
Sbjct: 796 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-HFFALHPFTGELSL 854
Query: 107 RAKSPIDC--ELQKEYTFIIQAYDC-GAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEP 163
+ + + TF+++A+D G P A V + VKD+N++ P F +
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-------TVTVIVKDMNDYPPVFSKR 907
Query: 164 AYKAVVTEGKIYDS-ILQVEAIDEDCSPQYSQICNYEIVTTDVPFAI------DRNGNIR 216
YK +V + + I V A D D + Y + P+ + +G +
Sbjct: 908 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 967
Query: 217 NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQP 272
L+ + ++++V A+D G+ + V++ V PG + EY+P
Sbjct: 968 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI---LVLHPGEIPRFTQEEYRP 1020
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 31/219 (14%)
Query: 54 ENNDTVILDPPLVALDKDA----PVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAK 109
E + +I+ PP+ A+D+D P G + + + E ++ + E L
Sbjct: 271 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLL 328
Query: 110 SPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVV 169
P++ + +++ +I+A P A +HI++ D N +P F P+Y+ +
Sbjct: 329 EPVNRDFHQKFDLVIKAEQDNGHPLPAF------AGLHIEILDENNQSPYFTMPSYQGYI 382
Query: 170 TE-----GKIYDSI-----LQVEAIDEDC----SPQYSQICN-YEIVTTDVPFAIDRNGN 214
E I DS+ L++ A+D+D P+ N Y V T I R
Sbjct: 383 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--Y 440
Query: 215 IRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
+ + + ++Q Y +TA+D Q+ ++ +V + V
Sbjct: 441 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 477
Score = 33.5 bits (75), Expect = 0.97
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 146 VHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSIL--------QVEAIDEDCSPQYSQICN 197
V I V+D N+ +PTFK +Y A V E + + ID+ + Q +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 198 Y--EIVTTDVPFAID--RNGNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Y + T++ F I GNI ++L+Y+ + +Y +++ A D Q
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,069,421
Number of Sequences: 37866
Number of extensions: 1875033
Number of successful extensions: 23403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 265
Number of HSP's that attempted gapping in prelim test: 13642
Number of HSP's gapped (non-prelim): 5027
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.