BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|206725526 signal-induced proliferation-associated protein 1 [Homo sapiens] (1042 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|206725526 signal-induced proliferation-associated protein 1 [... 2084 0.0 gi|206725523 signal-induced proliferation-associated protein 1 [... 2084 0.0 gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 639 0.0 gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 617 e-176 gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 614 e-175 gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57 gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57 gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 220 5e-57 gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 210 5e-54 gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 210 5e-54 gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 210 5e-54 gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 67 7e-11 gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 67 7e-11 gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 65 4e-10 gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 65 4e-10 gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 65 4e-10 gi|118600961 akt substrate AS250 [Homo sapiens] 64 6e-10 gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens] 41 0.005 gi|210031154 zinc finger protein 541 [Homo sapiens] 40 0.011 gi|221139926 NHS-like 1 [Homo sapiens] 40 0.015 gi|4505101 microtubule-associated protein 7 [Homo sapiens] 40 0.015 gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 39 0.020 gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens] 39 0.020 gi|112363080 microtubule associated serine/threonine kinase 2 [H... 39 0.020 gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 39 0.026 gi|4885583 Rho-associated, coiled-coil containing protein kinase... 39 0.026 gi|21536357 TBP-associated factor 6 isoform delta [Homo sapiens] 39 0.026 gi|5032147 TBP-associated factor 6 isoform alpha [Homo sapiens] 39 0.026 gi|21536359 TBP-associated factor 6 isoform alpha [Homo sapiens] 39 0.026 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 39 0.026 >gi|206725526 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 2084 bits (5400), Expect = 0.0 Identities = 1042/1042 (100%), Positives = 1042/1042 (100%) Query: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA Sbjct: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60 Query: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD Sbjct: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120 Query: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP Sbjct: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180 Query: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP Sbjct: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240 Query: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA Sbjct: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300 Query: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF Sbjct: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360 Query: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ Sbjct: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420 Query: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT Sbjct: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480 Query: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA Sbjct: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540 Query: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS Sbjct: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600 Query: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR Sbjct: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660 Query: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA Sbjct: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720 Query: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ Sbjct: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780 Query: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP Sbjct: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840 Query: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA Sbjct: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900 Query: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK Sbjct: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960 Query: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES Sbjct: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020 Query: 1021 ESAATRLLLASKQLGSPTADLA 1042 ESAATRLLLASKQLGSPTADLA Sbjct: 1021 ESAATRLLLASKQLGSPTADLA 1042 >gi|206725523 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 2084 bits (5400), Expect = 0.0 Identities = 1042/1042 (100%), Positives = 1042/1042 (100%) Query: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA Sbjct: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60 Query: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD Sbjct: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120 Query: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP Sbjct: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180 Query: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP Sbjct: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240 Query: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA Sbjct: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300 Query: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF Sbjct: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360 Query: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ Sbjct: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420 Query: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT Sbjct: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480 Query: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA Sbjct: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540 Query: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS Sbjct: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600 Query: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR Sbjct: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660 Query: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA Sbjct: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720 Query: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ Sbjct: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780 Query: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP Sbjct: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840 Query: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA Sbjct: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900 Query: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK Sbjct: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960 Query: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES Sbjct: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020 Query: 1021 ESAATRLLLASKQLGSPTADLA 1042 ESAATRLLLASKQLGSPTADLA Sbjct: 1021 ESAATRLLLASKQLGSPTADLA 1042 >gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo sapiens] Length = 1804 Score = 639 bits (1647), Expect = 0.0 Identities = 394/920 (42%), Positives = 526/920 (57%), Gaps = 126/920 (13%) Query: 104 EPAFPPVLEPRWFAHYDVQSLLFDW-------------------------APRSQGMGSH 138 E + P P+ FAHYDVQS+LFD A G SH Sbjct: 319 EDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSH 378 Query: 139 SEASSGTLASAEDQAA------------SSDLLHGAPGFVCELGGEGELGLG-------- 178 S + S + S ED + S++L+ P F E+GGEGE + Sbjct: 379 SASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGS 438 Query: 179 --GPASPPVPPALP----NAAVSILEEPQ-------NRTSAYSLEHADLGAGYYRKYFYG 225 G S L NA V++LE P+ +R Y +EH DLGA YYRK+FY Sbjct: 439 FSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQ 498 Query: 226 KEHQNFFGMDESLGPVAVSLRREEK-EGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPP 284 KEH N+FG DE+LGPVAVS+RRE+ E G+ ++YR+I RT++L TLRG++ EDA+P Sbjct: 499 KEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPS 558 Query: 285 ----GPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYC 340 RGL +++LEHV P+L+ CLRL +PKV L+ LDEQ L++Q+KVGI+YC Sbjct: 559 TAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYC 618 Query: 341 RAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQ 400 +AGQ +EEEMYNN+ AGPAF +FL LLG+ VRLKGFE YRAQLDTKTDSTGTHSLYTTY+ Sbjct: 619 KAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYK 678 Query: 401 DHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLV 460 D+EIMFHVSTMLPYTPNN+QQLLRKRHIGNDIVTIVFQEPG++PF P IRSHFQHVF++ Sbjct: 679 DYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVI 738 Query: 461 VRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGH 520 VR H PC+ Y VAV+R++D P+FGP +P G F + FR FLLAK +N E AA Sbjct: 739 VRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPK-GVTFPKSNVFRDFLLAKVINAENAAHK 797 Query: 521 ARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRG-PGAELQAAG 579 + +F AMATRTRQ+YL+DLA VT T +D + +F SL +++ + PGAEL + G Sbjct: 798 SEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMG 857 Query: 580 SLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLA 639 ++VW VRA + +E+ CLLGIS E +VL+ VVFNC+CRDV+ Sbjct: 858 AIVWAVRA-----------EDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIG 906 Query: 640 WTFSEQQLDLYHGRGEAITLRFDGS--PGQAVGEVVARLQLVSRGCETRELALPRDGQGR 697 WT ++ L +++ RGE +++ GS + + E+V RLQ VS+GCE+ E+ L R+G G+ Sbjct: 907 WTSTDTSLKIFYERGECVSV---GSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQ 963 Query: 698 LGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVT 757 LGF V+ EG V VE + +A AGLR G+RL+ +C + +L E LLR++ V V Sbjct: 964 LGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVV 1023 Query: 758 VLPPDESGRPRRSFSELYTLSLQEP--------------------SRRGAPDPVQDEVQG 797 ++PP + PRRS SE Y + + E R + P +V Sbjct: 1024 IIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPS 1083 Query: 798 VTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPD 857 P T + L+ DG PP ER + PRS SD P+ +P Sbjct: 1084 QVQSPMTSR-LNAGKGDGKMPP------PERAANI-------PRSISSDGRPLERRLSPG 1129 Query: 858 LLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRN----SI 913 + T S+ A S+ ++ P + S S D G+ R +P + SI Sbjct: 1130 SDIYVTVS-SMALARSQ---CRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASI 1185 Query: 914 SRIMSEA---GSGTLEDEWQ 930 R +++ GSG WQ Sbjct: 1186 DRQNTQSDIGGSGKSTPSWQ 1205 Score = 62.8 bits (151), Expect = 2e-09 Identities = 72/239 (30%), Positives = 112/239 (46%), Gaps = 35/239 (14%) Query: 802 PTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861 PT+++ LH L D +R F S R+SL D+A LPN D+L + Sbjct: 1574 PTSRRALHRTLSDESI------YNSQREHFFTS------RASLLDQA--LPN---DVLFS 1616 Query: 862 TTAKPSVPSA-----DSETPLTQDRPGSPSGS--------EDKGNPAPELRASFLPRTLS 908 +T PS+P + S T + G S S E + P P+ LP T + Sbjct: 1617 STY-PSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAA 1675 Query: 909 LRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAE 968 + S ++ A + ++ +A AS N S + + + + P S ++ Sbjct: 1676 DLDW-SNLVDAAKAYEVQ---RASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSK 1731 Query: 969 PEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRL 1027 L+ KV LE ML+ L+EDL+KEK D+A L+ EV+ LR +N RLQ ES++A+ +L Sbjct: 1732 DSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKL 1790 >gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo sapiens] Length = 1722 Score = 617 bits (1590), Expect = e-176 Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%) Query: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152 R FAHYDVQS+LF+ A R+ +G ++G A+++ Q Sbjct: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385 Query: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184 S+DL+ P F E GGEG+ G Sbjct: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445 Query: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237 + NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+ Sbjct: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505 Query: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291 LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL Sbjct: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565 Query: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351 +++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY Sbjct: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625 Query: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411 NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+ Sbjct: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685 Query: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471 LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT + Sbjct: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745 Query: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531 Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT Sbjct: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804 Query: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589 RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A Sbjct: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863 Query: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649 + A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + + Sbjct: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912 Query: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709 ++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V Sbjct: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972 Query: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769 VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR Sbjct: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032 Query: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829 SEL + + E L G+P E +T Sbjct: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058 Query: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881 F + +L P S S P P+ P L A+ ++P + S + L Sbjct: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117 Query: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926 SPS +P P + P+ ++ GSG LE Sbjct: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162 Score = 63.5 bits (153), Expect = 1e-09 Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%) Query: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886 S RSS+ D+A LPN D+L +TT PS+ S +E + S Sbjct: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557 Query: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941 D G P P+ + + + S+ G L + + +AS C Sbjct: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617 Query: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997 + EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK Sbjct: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677 Query: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027 D+A L+ EV+ LR +N RLQ ES++A +L Sbjct: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707 >gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo sapiens] Length = 1781 Score = 614 bits (1583), Expect = e-175 Identities = 374/858 (43%), Positives = 489/858 (56%), Gaps = 112/858 (13%) Query: 99 PAEEPEPAFPPVLEPRW-----FAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQA 153 P E E PP W FAH+DVQS+LFD + S S+ + T ++ A Sbjct: 318 PGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASA 377 Query: 154 ASS-----------------------------------------DLLHGAPGFVCELGGE 172 AS+ DLL P F E+GGE Sbjct: 378 ASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGE 437 Query: 173 GE-------LGLGGPAS-------PPVPPALPNAAVSILEEP------QNRTSAYSLEHA 212 E +G P+S P + NA++S+LE P Q+R YS+EH Sbjct: 438 CERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRTQSRPRQYSIEHV 497 Query: 213 DLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEG-SGGGTLHSYRVIVRTTQLR 271 DLGA YY+ YF GKEH N+FG+DE LGPVAVS++RE+ E G + YR+I RT +L Sbjct: 498 DLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTRELI 557 Query: 272 TLRGTISEDALPP----GPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQ 327 TLRG+I EDA P G RGL + LE+V P+L+ CLRL +PKV LL LDEQ Sbjct: 558 TLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQ 617 Query: 328 VLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKT 387 L + KVGILYC+AGQ SEEEMYNN+EAGPAF +FL+L+G+ V LKGF Y AQLD KT Sbjct: 618 GLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKT 677 Query: 388 DSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCP 447 DSTGTHSLYT YQD+EIMFHVST+LPYTPNN+QQLLRKRHIGNDIVTI+FQEPG+ PF P Sbjct: 678 DSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTP 737 Query: 448 TTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFL 507 IRSHFQHVF++VR H PCT + Y +AV+R++D P FGP +P+ G F + FR FL Sbjct: 738 KNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPS-GTTFRKSDVFRDFL 796 Query: 508 LAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAA 567 LAK +N E AA + +FH MATRTRQ+YL+DLA N V+ T +DS +F L SL +++ Sbjct: 797 LAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEK 856 Query: 568 PRG-PGAELQAAGSLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDG 626 + GAE +AG++ W V A A +G+E+ C+LGIS E +VL+ R Sbjct: 857 TKARAGAEQHSAGAIAWRVVAQDYA-----------QGVEIDCILGISNEFVVLLDLRTK 905 Query: 627 RVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETR 686 VVFNC C DV+ WT L +++GRG+ I L+ + + E+V RL++++ G ET Sbjct: 906 EVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETV 965 Query: 687 ELALPRDGQGRLGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQ 746 ++ L R+G G+LGF V +G V VE + FA AGLR G+RL+ +C + +L + Sbjct: 966 DMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMID 1025 Query: 747 LLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQ 806 LLR++ V V ++PP E G PRR + E Y ++ EP + E + +T Sbjct: 1026 LLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEP---------KTEQESIT------- 1069 Query: 807 LLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKP 866 GG PP + A + S NSL P S + P P L P Sbjct: 1070 -------PGGRPPYRSN-APWQWSGPASHNSL-PASKWA--TPTTPGHAQSLSRPLKQTP 1118 Query: 867 SVPSADSETPLTQDRPGS 884 VP +S+ PL RP S Sbjct: 1119 IVPFRESQ-PLHSKRPVS 1135 Score = 70.1 bits (170), Expect = 1e-11 Identities = 73/215 (33%), Positives = 95/215 (44%), Gaps = 12/215 (5%) Query: 816 GSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSE 874 G PG P D+ T S + R PV P TP K S SA SE Sbjct: 1562 GLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISA-SE 1620 Query: 875 TPLTQDRPGSPSGSEDKG-NPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQAIS 933 L R P D G P P+ A +L + +L D A+S Sbjct: 1621 LSLADGRD-RPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDP--ALS 1677 Query: 934 -EIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDL 992 +I + + LS E P P+ TP EP P +L+ KV LE ML++L DL Sbjct: 1678 PDIPPAHSPVHSHLSLERGP----PTPRTTPTMSEEP-PLDLTGKVYQLEVMLKQLHTDL 1732 Query: 993 QKEKADRAALEEEVRSLRHNNRRLQAESESAATRL 1027 QKEK D+ L+ EV SLR NN+RLQ ES++A+ +L Sbjct: 1733 QKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQL 1767 >gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2 [Homo sapiens] Length = 715 Score = 222 bits (565), Expect = 2e-57 Identities = 139/353 (39%), Positives = 195/353 (55%), Gaps = 25/353 (7%) Query: 195 SILEEPQN-----RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREE 249 SI EE + T Y LE A YR++F GK+H NF+ SLG + +S++ EE Sbjct: 114 SICEEEEEDNLSPNTFGYKLECKG-EARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEE 172 Query: 250 KEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLR 309 EG + RVI+R+ +L+T+ I P GLS + +A + Sbjct: 173 AEG-----IEYLRVILRS-KLKTVHERI--------PLAGLSKLPSVPQIAKAFCDDAVG 218 Query: 310 LGSAS---PKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTL 366 L PK + +++ DE ++ K G++Y +A Q EEE++ N E PAF +FL L Sbjct: 219 LRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDL 278 Query: 367 LGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKR 426 LGD + L+ F+ +R LD TG S+YTT++D EIMFHVST LP+T + QQL RKR Sbjct: 279 LGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKR 338 Query: 427 HIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAF 486 HIGNDIV I+FQE + PF P I S+F H ++VV+ TP T +Y+V+V+ +D P F Sbjct: 339 HIGNDIVAIIFQEENT-PFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTF 397 Query: 487 GPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 GP LP+ F +FR FLL K N E A + +F + RTR L +L Sbjct: 398 GPPLPS-PPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 449 >gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1 [Homo sapiens] Length = 730 Score = 222 bits (565), Expect = 2e-57 Identities = 139/353 (39%), Positives = 195/353 (55%), Gaps = 25/353 (7%) Query: 195 SILEEPQN-----RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREE 249 SI EE + T Y LE A YR++F GK+H NF+ SLG + +S++ EE Sbjct: 129 SICEEEEEDNLSPNTFGYKLECKG-EARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEE 187 Query: 250 KEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLR 309 EG + RVI+R+ +L+T+ I P GLS + +A + Sbjct: 188 AEG-----IEYLRVILRS-KLKTVHERI--------PLAGLSKLPSVPQIAKAFCDDAVG 233 Query: 310 LGSAS---PKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTL 366 L PK + +++ DE ++ K G++Y +A Q EEE++ N E PAF +FL L Sbjct: 234 LRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDL 293 Query: 367 LGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKR 426 LGD + L+ F+ +R LD TG S+YTT++D EIMFHVST LP+T + QQL RKR Sbjct: 294 LGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKR 353 Query: 427 HIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAF 486 HIGNDIV I+FQE + PF P I S+F H ++VV+ TP T +Y+V+V+ +D P F Sbjct: 354 HIGNDIVAIIFQEENT-PFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTF 412 Query: 487 GPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 GP LP+ F +FR FLL K N E A + +F + RTR L +L Sbjct: 413 GPPLPS-PPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 464 >gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sapiens] Length = 1013 Score = 220 bits (561), Expect = 5e-57 Identities = 134/340 (39%), Positives = 187/340 (55%), Gaps = 18/340 (5%) Query: 203 RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYR 262 R + LE+ + +Y KYF G+ HQN+ G D P +S+ ++ + YR Sbjct: 83 RRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQ---RVPQYR 139 Query: 263 VIV-RTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTL 321 I+ R T + + LP P + LS + +L + R P++ + L Sbjct: 140 AILWRKTGTQKI-------CLPYSPTKTLSVKSILSAMNLDKFEKGPR-EIFHPEIQKDL 191 Query: 322 LTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRA 381 L L+EQ S K G+L+ + GQ +++EM++N+ F +FL LLGD + LKG+ YR Sbjct: 192 LVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRG 251 Query: 382 QLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQ--E 439 LDTK D+TG HS+YT YQ HEIMFHVSTMLPY+ N+QQ+ RKRHIGNDIVTIVFQ E Sbjct: 252 GLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGE 311 Query: 440 PGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAA 499 S F P+ IRSHF H+F +VR + + YR+ + + P FGP LP F Sbjct: 312 ESSPAFKPSMIRSHFTHIFALVRYN---QQNDNYRLKIFSEESVPLFGPPLPT-PPVFTD 367 Query: 500 NADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 + +FR FLL K +NGE+A F RT ++ L Sbjct: 368 HQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSL 407 Score = 30.8 bits (68), Expect = 7.0 Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 2/88 (2%) Query: 803 TTKQLLHLCLQDGGSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861 T ++LL L + G G P ++ R SQ P + S + +P+ + + Sbjct: 909 TRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAST 968 Query: 862 TTAKPSVPSADSETPLTQDRPGSP-SGS 888 + A P SA S+ DR GSP SGS Sbjct: 969 SEANPEGHSASSDQDPVADREGSPVSGS 996 >gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens] Length = 663 Score = 210 bits (535), Expect = 5e-54 Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%) Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257 E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G Sbjct: 70 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 123 Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317 R+++RT + RT I L P + + E V L PK Sbjct: 124 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 177 Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377 R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+ Sbjct: 178 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 237 Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437 +R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF Sbjct: 238 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 297 Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497 Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F Sbjct: 298 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 355 Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 +F+ FLL K +N E A A +F + RTR L+ L Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 397 >gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens] Length = 727 Score = 210 bits (535), Expect = 5e-54 Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%) Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257 E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G Sbjct: 134 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 187 Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317 R+++RT + RT I L P + + E V L PK Sbjct: 188 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 241 Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377 R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+ Sbjct: 242 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 301 Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437 +R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF Sbjct: 302 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 361 Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497 Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F Sbjct: 362 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 419 Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 +F+ FLL K +N E A A +F + RTR L+ L Sbjct: 420 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 461 >gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens] Length = 681 Score = 210 bits (535), Expect = 5e-54 Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%) Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257 E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G Sbjct: 70 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 123 Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317 R+++RT + RT I L P + + E V L PK Sbjct: 124 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 177 Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377 R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+ Sbjct: 178 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 237 Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437 +R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF Sbjct: 238 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 297 Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497 Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F Sbjct: 298 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 355 Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539 +F+ FLL K +N E A A +F + RTR L+ L Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 397 >gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2 [Homo sapiens] Length = 2083 Score = 67.4 bits (163), Expect = 7e-11 Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 12/236 (5%) Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375 K+ R L LD + K+ + Y GQ + + N A+ F+ LG V L Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850 Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434 + L K STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1851 HCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907 Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494 IV+ E ++ + I + F V +V+ P H + + + + + P FGP Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVI---YPMKNH-MFSIQIMKKPEVPFFGPLF---D 1959 Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLD 550 G + A A+N +A + R +YLQ + + + T+ + Sbjct: 1960 GAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015 >gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1 [Homo sapiens] Length = 2036 Score = 67.4 bits (163), Expect = 7e-11 Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 12/236 (5%) Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375 K+ R L LD + K+ + Y GQ + + N A+ F+ LG V L Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850 Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434 + L K STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1851 HCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907 Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494 IV+ E ++ + I + F V +V+ P H + + + + + P FGP Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVI---YPMKNH-MFSIQIMKKPEVPFFGPLF---D 1959 Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLD 550 G + A A+N +A + R +YLQ + + + T+ + Sbjct: 1960 GAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015 >gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] Length = 1740 Score = 64.7 bits (156), Expect = 4e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512 Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 1513 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571 Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 1572 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1606 >gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] Length = 1807 Score = 64.7 bits (156), Expect = 4e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579 Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638 Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673 >gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] Length = 1784 Score = 64.7 bits (156), Expect = 4e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556 Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 1557 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615 Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 1616 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1650 >gi|118600961 akt substrate AS250 [Homo sapiens] Length = 1873 Score = 64.3 bits (155), Expect = 6e-10 Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 15/247 (6%) Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375 K+ R L LD + K+ + Y GQ + + +N+ A+ F+ LG V L Sbjct: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689 Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434 + L + STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746 Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494 IV+ E S+ + I + F V +++ P H + +A+++ + P FGP Sbjct: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIII---YPMKNHMFF-IAITKKPEVPFFGPLF---D 1798 Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATN--EVTTTSLDSA 552 G + + + A +N +A + R YL+ + N EV T D A Sbjct: 1799 GAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFE-DFA 1857 Query: 553 SRFGLPS 559 ++ PS Sbjct: 1858 AQVFSPS 1864 >gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens] Length = 1989 Score = 41.2 bits (95), Expect = 0.005 Identities = 69/291 (23%), Positives = 124/291 (42%), Gaps = 25/291 (8%) Query: 758 VLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPV-QDEVQGVTL----LPTTKQLLHLCL 812 V PP S FS +LSL P + + P+ Q V+G+ + LP L L Sbjct: 547 VQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPP 606 Query: 813 QDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSAD 872 +D PP P EE E + + L SL+++ P T + + PS P + Sbjct: 607 EDPEQPPKPPFADEEEEEEMLLREELL--KSLANKRAFKPEETS----SNSDPPSPPVLN 660 Query: 873 SETPLTQDRPGSPS---GSEDKGNPAPELRASFLPRT-LSLRNSISRIMSEAGSGTLEDE 928 + P+ + S S+ + R LPRT +SL S +++ S D+ Sbjct: 661 NSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDS----DD 716 Query: 929 WQAISEIASTCNTI---LESLSREGQPIPESGD-PKGTPKSDAEPEPGNLSEKVSHLESM 984 ++ E + + N++ LES+ +E + E PK PKS+ E +P E + + + Sbjct: 717 SESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKI 776 Query: 985 -LRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQL 1034 R L+E++ + R +++++ + E + R+ + +KQ+ Sbjct: 777 EYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIG-RIAMVTKQV 826 >gi|210031154 zinc finger protein 541 [Homo sapiens] Length = 1365 Score = 40.0 bits (92), Expect = 0.011 Identities = 52/220 (23%), Positives = 83/220 (37%), Gaps = 8/220 (3%) Query: 750 SAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLH 809 +AP T LP + + ++++T + GAPDP + E L + Sbjct: 325 AAPAALDTELPEEPCLPQKEPATDVFTAPNSRAAENGAPDPPEPEPDTALLQARSTA--- 381 Query: 810 LCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVP 869 C +GGS P L +T SQ S L + P P + + + +VP Sbjct: 382 ECWPEGGSVPACLPLFRGQTVPASSQPSSHSFQWLRN-LPGCPKSKGNNVFVVHKPSAVP 440 Query: 870 SADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEW 929 S + GSPS E P L + LP +L + S+ S + ED+ Sbjct: 441 SREGSESGPGPSSGSPS-EESPPGPGGGLEDA-LPFPAALLRVPAEAPSDPRSASGEDDP 498 Query: 930 QAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEP 969 A ++ C++ L G+P + G +DA P Sbjct: 499 CAPKKVKVDCDSFL--CQNPGEPGLQEAQKAGGLPADASP 536 >gi|221139926 NHS-like 1 [Homo sapiens] Length = 1606 Score = 39.7 bits (91), Expect = 0.015 Identities = 53/175 (30%), Positives = 72/175 (41%), Gaps = 25/175 (14%) Query: 736 LPSLRPEAAAQLLRSAPKVCVTVLPP-DESGRPRRSFSELYTLSL-QEPSRRGAPDPVQD 793 LPS P A L PK PP SG+P S L S +E SR P + Sbjct: 1015 LPSSEPPPAPPL---DPKFMKDTRPPFTNSGQPESSRGSLRPPSTKEETSRPPMPLITTE 1071 Query: 794 EVQGVTLLPTTK-------QLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSD 846 +Q V L P K QL Q+ +P P + + FL S+NS + S S Sbjct: 1072 ALQMVQLRPVRKNSGAEAAQLSERTAQEQRTPVAP-QYHLKPSAFLKSRNSTNEMESESQ 1130 Query: 847 EAPVLPNTTPDLLLATTAKPSVP-----SADSETPLTQDRPGSPSGSEDKGNPAP 896 A V + L T AK S +A+ P+++ PG+PS E + P+P Sbjct: 1131 PASVTSS------LPTPAKSSSQGDHGSAAERGGPVSRS-PGAPSAGEAEARPSP 1178 >gi|4505101 microtubule-associated protein 7 [Homo sapiens] Length = 749 Score = 39.7 bits (91), Expect = 0.015 Identities = 48/219 (21%), Positives = 81/219 (36%), Gaps = 21/219 (9%) Query: 818 PPGPGDLAEERTEFLHSQNSLSPRS---------SLSDEAPVLPNTTPDLLLATTAKPSV 868 PP PG++ + E P SL AP++ + T A+P V Sbjct: 363 PPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEV 422 Query: 869 -PSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLED 927 P+A + P P S PAP + + S N+ + + + AG+ E+ Sbjct: 423 GPAAPAMAPAPASAPAPASAPA----PAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEE 478 Query: 928 EWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRK 987 + ++E E RE + E K + E E+ + E R+ Sbjct: 479 ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE-----ERTTRREEESRR 533 Query: 988 LQEDLQKEKADRAALEEEVRSLRHNN--RRLQAESESAA 1024 L+ + +EK ++ + E R+LR R Q + E A Sbjct: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEA 572 Score = 30.8 bits (68), Expect = 7.0 Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%) Query: 980 HLESMLRKLQEDLQKEKADRAALEEEVRS-LRHNNRRLQA 1018 HLE ++L+E QKE+ RAA+EE+ R L + R +A Sbjct: 102 HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEA 141 >gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 [Homo sapiens] Length = 559 Score = 39.3 bits (90), Expect = 0.020 Identities = 40/145 (27%), Positives = 63/145 (43%), Gaps = 18/145 (12%) Query: 866 PSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRAS--FLPRTLSLRNSISRIMSEAGSG 923 P P A S+ P T D P PS + K + + R++ PRT S + + ++ S Sbjct: 277 PPPPRASSKRPATADSP-KPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSS 335 Query: 924 TLEDEWQAISE--IASTCNTILESLSRE--------GQPIPESGDPKGTPKSDAEPEPGN 973 T ++ +A SE A + ES S + Q P + SD++ EP Sbjct: 336 TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395 Query: 974 LSEKVSHLESMLRKLQEDLQKEKAD 998 +H + LR + EDLQ E++D Sbjct: 396 -----NHSQGPLRSMVEDLQSEESD 415 >gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens] Length = 1522 Score = 39.3 bits (90), Expect = 0.020 Identities = 65/262 (24%), Positives = 98/262 (37%), Gaps = 43/262 (16%) Query: 740 RPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPV-------Q 792 +P AAA L+ + +T LP D + P L LQ+ AP PV Q Sbjct: 818 KPVAAATLVSQQAEEGLT-LPQDSAMTP--------PLPLQDTDLSSAPKPVAAATPVSQ 868 Query: 793 DEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP-----RSSLSDE 847 +G+TL + L LQD G GP LA + L ++ +P + E Sbjct: 869 QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQE 928 Query: 848 APVLPNTTPDLLLATTAKPSVPSADSETPLTQDRP------GSPSGSEDKGNPAPELRAS 901 P A P+VP + + QD P G+P +++ + + A Sbjct: 929 VGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEAL 988 Query: 902 FLPRTLS-----LRNSISRIMSEA--------GSGTLEDEWQAIS-EIASTCNTILESLS 947 LP S + ++SR EA G G D Q + E+ + L+ L+ Sbjct: 989 SLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1048 Query: 948 REGQPIPESGDPKGTPKSDAEP 969 +E P G + P DA P Sbjct: 1049 QEHGPRSALGGAREVP--DAPP 1068 >gi|112363080 microtubule associated serine/threonine kinase 2 [Homo sapiens] Length = 1798 Score = 39.3 bits (90), Expect = 0.020 Identities = 86/325 (26%), Positives = 119/325 (36%), Gaps = 68/325 (20%) Query: 708 VTHVERFTFAETAGLRPGARLLRVCGQTLPSL-RPEAAAQLLRSAPKVCVTVLPPDESG- 765 V HVE A AGLR G + V G+ + L E +L+S KV ++ P + + Sbjct: 1137 VWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSI 1196 Query: 766 --RPRRSFSELYTLSLQEPSRRGAPDPVQDE----------VQGVTLLPTTKQL--LHLC 811 P R S Y + S+R Q+ + +LL T++ L L+ Sbjct: 1197 KVGPARKGS--YKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRS 1254 Query: 812 LQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSA 871 L G S PG HS +SLSPRS TPD + + S S+ Sbjct: 1255 LSSGESGPGSP---------THS-HSLSPRSPTQGY-----RVTPDAVHSVGGNSSQSSS 1299 Query: 872 DSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQA 931 S + P SP+GS G+ P P+ S R AGS L Sbjct: 1300 PSSSV-----PSSPAGS---GHTRPSSLHGLAPKLQRQYRSPRR--KSAGSIPL------ 1343 Query: 932 ISEIASTCNTILESLSREGQPIPESG-------------DPKG----TPKSDAEPEPGNL 974 S +A T + + S + P P SG P G PKS AEP L Sbjct: 1344 -SPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKS-AEPPRSPL 1401 Query: 975 SEKVSHLESMLRKLQEDLQKEKADR 999 ++V E + L +K R Sbjct: 1402 LKRVQSAEKLAAALAASEKKLATSR 1426 >gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein [Homo sapiens] Length = 1211 Score = 38.9 bits (89), Expect = 0.026 Identities = 29/84 (34%), Positives = 39/84 (46%), Gaps = 7/84 (8%) Query: 689 ALPRDGQG---RLGFEVDAEG--FVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEA 743 A P QG GF + G FV V + + A GLRPG ++L V G + L E Sbjct: 5 ATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRER 64 Query: 744 AAQLLRSAPKV--CVTVLPPDESG 765 +L R P+V + VLP + G Sbjct: 65 LVRLARRCPRVPPSLGVLPAPDGG 88 >gi|4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapiens] Length = 1354 Score = 38.9 bits (89), Expect = 0.026 Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 38/156 (24%) Query: 924 TLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDA---EPEPGNLSEKVSH 980 TL+D+ + + +++ E LS+ + + E+ D T A +S+ +S Sbjct: 518 TLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ 577 Query: 981 LESMLRKLQED---------------------LQKEKADRA--------------ALEEE 1005 LES+ R+LQE L+ E+ DR +L+EE Sbjct: 578 LESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEE 637 Query: 1006 VRSLRHNNRRLQAESESAATRLLLASKQLGSPTADL 1041 V+ L+HN +++ E + A L + K+ + DL Sbjct: 638 VKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDL 673 >gi|21536357 TBP-associated factor 6 isoform delta [Homo sapiens] Length = 667 Score = 38.9 bits (89), Expect = 0.026 Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%) Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787 LL+ C L LRP PPD R F L L + + A Sbjct: 417 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 458 Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845 +Q + T L T+ L L P PG L + L Q +S R++ Sbjct: 459 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 516 Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905 AP P+ P + ++ S PS L+ PGS S + P Sbjct: 517 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 561 Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965 T ++ S+ I+ + T A S S I+ SL P +G+ KG P S Sbjct: 562 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 613 Query: 966 DAEPEP 971 P P Sbjct: 614 HPSPVP 619 Score = 32.0 bits (71), Expect = 3.1 Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79 P+ P P P+ G L G +AG++ PP P +P+A S Sbjct: 617 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 662 >gi|5032147 TBP-associated factor 6 isoform alpha [Homo sapiens] Length = 677 Score = 38.9 bits (89), Expect = 0.026 Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%) Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787 LL+ C L LRP PPD R F L L + + A Sbjct: 427 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 468 Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845 +Q + T L T+ L L P PG L + L Q +S R++ Sbjct: 469 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 526 Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905 AP P+ P + ++ S PS L+ PGS S + P Sbjct: 527 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 571 Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965 T ++ S+ I+ + T A S S I+ SL P +G+ KG P S Sbjct: 572 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 623 Query: 966 DAEPEP 971 P P Sbjct: 624 HPSPVP 629 Score = 32.0 bits (71), Expect = 3.1 Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79 P+ P P P+ G L G +AG++ PP P +P+A S Sbjct: 627 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 672 >gi|21536359 TBP-associated factor 6 isoform alpha [Homo sapiens] Length = 677 Score = 38.9 bits (89), Expect = 0.026 Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%) Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787 LL+ C L LRP PPD R F L L + + A Sbjct: 427 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 468 Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845 +Q + T L T+ L L P PG L + L Q +S R++ Sbjct: 469 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 526 Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905 AP P+ P + ++ S PS L+ PGS S + P Sbjct: 527 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 571 Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965 T ++ S+ I+ + T A S S I+ SL P +G+ KG P S Sbjct: 572 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 623 Query: 966 DAEPEP 971 P P Sbjct: 624 HPSPVP 629 Score = 32.0 bits (71), Expect = 3.1 Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79 P+ P P P+ G L G +AG++ PP P +P+A S Sbjct: 627 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 672 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 38.9 bits (89), Expect = 0.026 Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 14/215 (6%) Query: 832 LHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSG---- 887 L N SPR LS V T+P LL ++ + PSA S++ +T +R SPS Sbjct: 2375 LSGANLTSPRVPLSAYERVSGRTSPPLLDRARSR-TPPSAPSQSRMTSERAPSPSSRMGQ 2433 Query: 888 --SEDKGNPAPELRASFLPRTLS--LRNSISRIMSEAGSGTLEDEWQAISEIASTCNTIL 943 S+ PA + S +P S R I++ AGS +L A + ++ + + Sbjct: 2434 APSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGM 2493 Query: 944 ESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALE 1003 S+ G P + G+P P S +P L+ E R + ++ Sbjct: 2494 LSVPAPGVPHSDVGEP---PASTGAQQPSALAALQPAKER--RSSSSSSSSSSSSSSSSS 2548 Query: 1004 EEVRSLRHNNRRLQAESESAATRLLLASKQLGSPT 1038 S + +E S + +A K++ SPT Sbjct: 2549 SSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPT 2583 Score = 38.1 bits (87), Expect = 0.044 Identities = 44/173 (25%), Positives = 69/173 (39%), Gaps = 29/173 (16%) Query: 816 GSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEA---PVLPNTTPDLLLATTAKPSVPSAD 872 G+PP G + + ++ S++P+ E+ P L + TP + + P P Sbjct: 847 GTPPRQGSITSPQA----NEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSP--PRVK 900 Query: 873 SETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQAI 932 S TP Q SPS S +P P+++A PR S S S S S T +++ Sbjct: 901 SSTPPRQ----SPSRSS---SPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSV 953 Query: 933 SEIASTCNTILESLSREGQPIPE-------------SGDPKGTPKSDAEPEPG 972 S ++ + +L S G P+ SG PK A+ PG Sbjct: 954 SPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG 1006 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.132 0.390 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,015,574 Number of Sequences: 37866 Number of extensions: 2754823 Number of successful extensions: 14552 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 110 Number of HSP's successfully gapped in prelim test: 371 Number of HSP's that attempted gapping in prelim test: 12261 Number of HSP's gapped (non-prelim): 2632 length of query: 1042 length of database: 18,247,518 effective HSP length: 112 effective length of query: 930 effective length of database: 14,006,526 effective search space: 13026069180 effective search space used: 13026069180 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.