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Search of human proteins with 206725523
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|206725523 signal-induced proliferation-associated protein 1
[Homo sapiens]
(1042 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|206725526 signal-induced proliferation-associated protein 1 [... 2084 0.0
gi|206725523 signal-induced proliferation-associated protein 1 [... 2084 0.0
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 639 0.0
gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 617 e-176
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 614 e-175
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 220 5e-57
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 210 5e-54
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 210 5e-54
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 210 5e-54
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 67 7e-11
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 67 7e-11
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 65 4e-10
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 65 4e-10
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 65 4e-10
gi|118600961 akt substrate AS250 [Homo sapiens] 64 6e-10
gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens] 41 0.005
gi|210031154 zinc finger protein 541 [Homo sapiens] 40 0.011
gi|221139926 NHS-like 1 [Homo sapiens] 40 0.015
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 40 0.015
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 39 0.020
gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens] 39 0.020
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 39 0.020
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 39 0.026
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 39 0.026
gi|21536357 TBP-associated factor 6 isoform delta [Homo sapiens] 39 0.026
gi|5032147 TBP-associated factor 6 isoform alpha [Homo sapiens] 39 0.026
gi|21536359 TBP-associated factor 6 isoform alpha [Homo sapiens] 39 0.026
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 39 0.026
>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 2084 bits (5400), Expect = 0.0
Identities = 1042/1042 (100%), Positives = 1042/1042 (100%)
Query: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA
Sbjct: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60
Query: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120
RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD
Sbjct: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120
Query: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180
VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
Sbjct: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180
Query: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP
Sbjct: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240
Query: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300
VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA
Sbjct: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300
Query: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360
PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF
Sbjct: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360
Query: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420
MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ
Sbjct: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420
Query: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480
QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT
Sbjct: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480
Query: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540
QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA
Sbjct: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540
Query: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600
TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS
Sbjct: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600
Query: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660
GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR
Sbjct: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660
Query: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720
FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA
Sbjct: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720
Query: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780
GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ
Sbjct: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780
Query: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840
EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP
Sbjct: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840
Query: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900
RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA
Sbjct: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900
Query: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960
SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK
Sbjct: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960
Query: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020
GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES
Sbjct: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020
Query: 1021 ESAATRLLLASKQLGSPTADLA 1042
ESAATRLLLASKQLGSPTADLA
Sbjct: 1021 ESAATRLLLASKQLGSPTADLA 1042
>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 2084 bits (5400), Expect = 0.0
Identities = 1042/1042 (100%), Positives = 1042/1042 (100%)
Query: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA
Sbjct: 1 MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEA 60
Query: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120
RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD
Sbjct: 61 RPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYD 120
Query: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180
VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
Sbjct: 121 VQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP 180
Query: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP
Sbjct: 181 ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGP 240
Query: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300
VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA
Sbjct: 241 VAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVA 300
Query: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360
PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF
Sbjct: 301 PQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF 360
Query: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420
MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ
Sbjct: 361 MQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQ 420
Query: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480
QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT
Sbjct: 421 QLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRT 480
Query: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540
QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA
Sbjct: 481 QDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA 540
Query: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600
TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS
Sbjct: 541 TNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQAS 600
Query: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660
GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR
Sbjct: 601 GPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLR 660
Query: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720
FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA
Sbjct: 661 FDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETA 720
Query: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780
GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ
Sbjct: 721 GLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQ 780
Query: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840
EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP
Sbjct: 781 EPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP 840
Query: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900
RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA
Sbjct: 841 RSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRA 900
Query: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960
SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK
Sbjct: 901 SFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPK 960
Query: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020
GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES
Sbjct: 961 GTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAES 1020
Query: 1021 ESAATRLLLASKQLGSPTADLA 1042
ESAATRLLLASKQLGSPTADLA
Sbjct: 1021 ESAATRLLLASKQLGSPTADLA 1042
>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
sapiens]
Length = 1804
Score = 639 bits (1647), Expect = 0.0
Identities = 394/920 (42%), Positives = 526/920 (57%), Gaps = 126/920 (13%)
Query: 104 EPAFPPVLEPRWFAHYDVQSLLFDW-------------------------APRSQGMGSH 138
E + P P+ FAHYDVQS+LFD A G SH
Sbjct: 319 EDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSH 378
Query: 139 SEASSGTLASAEDQAA------------SSDLLHGAPGFVCELGGEGELGLG-------- 178
S + S + S ED + S++L+ P F E+GGEGE +
Sbjct: 379 SASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGS 438
Query: 179 --GPASPPVPPALP----NAAVSILEEPQ-------NRTSAYSLEHADLGAGYYRKYFYG 225
G S L NA V++LE P+ +R Y +EH DLGA YYRK+FY
Sbjct: 439 FSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQ 498
Query: 226 KEHQNFFGMDESLGPVAVSLRREEK-EGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPP 284
KEH N+FG DE+LGPVAVS+RRE+ E G+ ++YR+I RT++L TLRG++ EDA+P
Sbjct: 499 KEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPS 558
Query: 285 ----GPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYC 340
RGL +++LEHV P+L+ CLRL +PKV L+ LDEQ L++Q+KVGI+YC
Sbjct: 559 TAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYC 618
Query: 341 RAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQ 400
+AGQ +EEEMYNN+ AGPAF +FL LLG+ VRLKGFE YRAQLDTKTDSTGTHSLYTTY+
Sbjct: 619 KAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYK 678
Query: 401 DHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLV 460
D+EIMFHVSTMLPYTPNN+QQLLRKRHIGNDIVTIVFQEPG++PF P IRSHFQHVF++
Sbjct: 679 DYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVI 738
Query: 461 VRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGH 520
VR H PC+ Y VAV+R++D P+FGP +P G F + FR FLLAK +N E AA
Sbjct: 739 VRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPK-GVTFPKSNVFRDFLLAKVINAENAAHK 797
Query: 521 ARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRG-PGAELQAAG 579
+ +F AMATRTRQ+YL+DLA VT T +D + +F SL +++ + PGAEL + G
Sbjct: 798 SEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMG 857
Query: 580 SLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLA 639
++VW VRA + +E+ CLLGIS E +VL+ VVFNC+CRDV+
Sbjct: 858 AIVWAVRA-----------EDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIG 906
Query: 640 WTFSEQQLDLYHGRGEAITLRFDGS--PGQAVGEVVARLQLVSRGCETRELALPRDGQGR 697
WT ++ L +++ RGE +++ GS + + E+V RLQ VS+GCE+ E+ L R+G G+
Sbjct: 907 WTSTDTSLKIFYERGECVSV---GSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQ 963
Query: 698 LGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVT 757
LGF V+ EG V VE + +A AGLR G+RL+ +C + +L E LLR++ V V
Sbjct: 964 LGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVV 1023
Query: 758 VLPPDESGRPRRSFSELYTLSLQEP--------------------SRRGAPDPVQDEVQG 797
++PP + PRRS SE Y + + E R + P +V
Sbjct: 1024 IIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPS 1083
Query: 798 VTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPD 857
P T + L+ DG PP ER + PRS SD P+ +P
Sbjct: 1084 QVQSPMTSR-LNAGKGDGKMPP------PERAANI-------PRSISSDGRPLERRLSPG 1129
Query: 858 LLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRN----SI 913
+ T S+ A S+ ++ P + S S D G+ R +P + SI
Sbjct: 1130 SDIYVTVS-SMALARSQ---CRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASI 1185
Query: 914 SRIMSEA---GSGTLEDEWQ 930
R +++ GSG WQ
Sbjct: 1186 DRQNTQSDIGGSGKSTPSWQ 1205
Score = 62.8 bits (151), Expect = 2e-09
Identities = 72/239 (30%), Positives = 112/239 (46%), Gaps = 35/239 (14%)
Query: 802 PTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861
PT+++ LH L D +R F S R+SL D+A LPN D+L +
Sbjct: 1574 PTSRRALHRTLSDESI------YNSQREHFFTS------RASLLDQA--LPN---DVLFS 1616
Query: 862 TTAKPSVPSA-----DSETPLTQDRPGSPSGS--------EDKGNPAPELRASFLPRTLS 908
+T PS+P + S T + G S S E + P P+ LP T +
Sbjct: 1617 STY-PSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAA 1675
Query: 909 LRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAE 968
+ S ++ A + ++ +A AS N S + + + + P S ++
Sbjct: 1676 DLDW-SNLVDAAKAYEVQ---RASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSK 1731
Query: 969 PEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRL 1027
L+ KV LE ML+ L+EDL+KEK D+A L+ EV+ LR +N RLQ ES++A+ +L
Sbjct: 1732 DSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKL 1790
>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
sapiens]
Length = 1722
Score = 617 bits (1590), Expect = e-176
Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%)
Query: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152
R FAHYDVQS+LF+ A R+ +G ++G A+++ Q
Sbjct: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385
Query: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184
S+DL+ P F E GGEG+ G
Sbjct: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445
Query: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237
+ NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+
Sbjct: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505
Query: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291
LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL
Sbjct: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565
Query: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351
+++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY
Sbjct: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625
Query: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411
NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+
Sbjct: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685
Query: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471
LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT +
Sbjct: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745
Query: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531
Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT
Sbjct: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804
Query: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589
RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A
Sbjct: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863
Query: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649
+ A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + +
Sbjct: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912
Query: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709
++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V
Sbjct: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972
Query: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769
VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR
Sbjct: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032
Query: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829
SEL + + E L G+P E +T
Sbjct: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058
Query: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881
F + +L P S S P P+ P L A+ ++P + S + L
Sbjct: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117
Query: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926
SPS +P P + P+ ++ GSG LE
Sbjct: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162
Score = 63.5 bits (153), Expect = 1e-09
Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%)
Query: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886
S RSS+ D+A LPN D+L +TT PS+ S +E + S
Sbjct: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557
Query: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941
D G P P+ + + + S+ G L + + +AS C
Sbjct: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617
Query: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997
+ EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK
Sbjct: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677
Query: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027
D+A L+ EV+ LR +N RLQ ES++A +L
Sbjct: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707
>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
sapiens]
Length = 1781
Score = 614 bits (1583), Expect = e-175
Identities = 374/858 (43%), Positives = 489/858 (56%), Gaps = 112/858 (13%)
Query: 99 PAEEPEPAFPPVLEPRW-----FAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQA 153
P E E PP W FAH+DVQS+LFD + S S+ + T ++ A
Sbjct: 318 PGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASA 377
Query: 154 ASS-----------------------------------------DLLHGAPGFVCELGGE 172
AS+ DLL P F E+GGE
Sbjct: 378 ASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGE 437
Query: 173 GE-------LGLGGPAS-------PPVPPALPNAAVSILEEP------QNRTSAYSLEHA 212
E +G P+S P + NA++S+LE P Q+R YS+EH
Sbjct: 438 CERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRTQSRPRQYSIEHV 497
Query: 213 DLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEG-SGGGTLHSYRVIVRTTQLR 271
DLGA YY+ YF GKEH N+FG+DE LGPVAVS++RE+ E G + YR+I RT +L
Sbjct: 498 DLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTRELI 557
Query: 272 TLRGTISEDALPP----GPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQ 327
TLRG+I EDA P G RGL + LE+V P+L+ CLRL +PKV LL LDEQ
Sbjct: 558 TLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQ 617
Query: 328 VLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKT 387
L + KVGILYC+AGQ SEEEMYNN+EAGPAF +FL+L+G+ V LKGF Y AQLD KT
Sbjct: 618 GLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKT 677
Query: 388 DSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCP 447
DSTGTHSLYT YQD+EIMFHVST+LPYTPNN+QQLLRKRHIGNDIVTI+FQEPG+ PF P
Sbjct: 678 DSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTP 737
Query: 448 TTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFL 507
IRSHFQHVF++VR H PCT + Y +AV+R++D P FGP +P+ G F + FR FL
Sbjct: 738 KNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPS-GTTFRKSDVFRDFL 796
Query: 508 LAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAA 567
LAK +N E AA + +FH MATRTRQ+YL+DLA N V+ T +DS +F L SL +++
Sbjct: 797 LAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEK 856
Query: 568 PRG-PGAELQAAGSLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDG 626
+ GAE +AG++ W V A A +G+E+ C+LGIS E +VL+ R
Sbjct: 857 TKARAGAEQHSAGAIAWRVVAQDYA-----------QGVEIDCILGISNEFVVLLDLRTK 905
Query: 627 RVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETR 686
VVFNC C DV+ WT L +++GRG+ I L+ + + E+V RL++++ G ET
Sbjct: 906 EVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETV 965
Query: 687 ELALPRDGQGRLGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQ 746
++ L R+G G+LGF V +G V VE + FA AGLR G+RL+ +C + +L +
Sbjct: 966 DMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMID 1025
Query: 747 LLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQ 806
LLR++ V V ++PP E G PRR + E Y ++ EP + E + +T
Sbjct: 1026 LLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEP---------KTEQESIT------- 1069
Query: 807 LLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKP 866
GG PP + A + S NSL P S + P P L P
Sbjct: 1070 -------PGGRPPYRSN-APWQWSGPASHNSL-PASKWA--TPTTPGHAQSLSRPLKQTP 1118
Query: 867 SVPSADSETPLTQDRPGS 884
VP +S+ PL RP S
Sbjct: 1119 IVPFRESQ-PLHSKRPVS 1135
Score = 70.1 bits (170), Expect = 1e-11
Identities = 73/215 (33%), Positives = 95/215 (44%), Gaps = 12/215 (5%)
Query: 816 GSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSE 874
G PG P D+ T S + R PV P TP K S SA SE
Sbjct: 1562 GLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISA-SE 1620
Query: 875 TPLTQDRPGSPSGSEDKG-NPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQAIS 933
L R P D G P P+ A +L + +L D A+S
Sbjct: 1621 LSLADGRD-RPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDP--ALS 1677
Query: 934 -EIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDL 992
+I + + LS E P P+ TP EP P +L+ KV LE ML++L DL
Sbjct: 1678 PDIPPAHSPVHSHLSLERGP----PTPRTTPTMSEEP-PLDLTGKVYQLEVMLKQLHTDL 1732
Query: 993 QKEKADRAALEEEVRSLRHNNRRLQAESESAATRL 1027
QKEK D+ L+ EV SLR NN+RLQ ES++A+ +L
Sbjct: 1733 QKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQL 1767
>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
[Homo sapiens]
Length = 715
Score = 222 bits (565), Expect = 2e-57
Identities = 139/353 (39%), Positives = 195/353 (55%), Gaps = 25/353 (7%)
Query: 195 SILEEPQN-----RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREE 249
SI EE + T Y LE A YR++F GK+H NF+ SLG + +S++ EE
Sbjct: 114 SICEEEEEDNLSPNTFGYKLECKG-EARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEE 172
Query: 250 KEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLR 309
EG + RVI+R+ +L+T+ I P GLS + +A +
Sbjct: 173 AEG-----IEYLRVILRS-KLKTVHERI--------PLAGLSKLPSVPQIAKAFCDDAVG 218
Query: 310 LGSAS---PKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTL 366
L PK + +++ DE ++ K G++Y +A Q EEE++ N E PAF +FL L
Sbjct: 219 LRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDL 278
Query: 367 LGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKR 426
LGD + L+ F+ +R LD TG S+YTT++D EIMFHVST LP+T + QQL RKR
Sbjct: 279 LGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKR 338
Query: 427 HIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAF 486
HIGNDIV I+FQE + PF P I S+F H ++VV+ TP T +Y+V+V+ +D P F
Sbjct: 339 HIGNDIVAIIFQEENT-PFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTF 397
Query: 487 GPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
GP LP+ F +FR FLL K N E A + +F + RTR L +L
Sbjct: 398 GPPLPS-PPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 449
>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
[Homo sapiens]
Length = 730
Score = 222 bits (565), Expect = 2e-57
Identities = 139/353 (39%), Positives = 195/353 (55%), Gaps = 25/353 (7%)
Query: 195 SILEEPQN-----RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREE 249
SI EE + T Y LE A YR++F GK+H NF+ SLG + +S++ EE
Sbjct: 129 SICEEEEEDNLSPNTFGYKLECKG-EARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEE 187
Query: 250 KEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLR 309
EG + RVI+R+ +L+T+ I P GLS + +A +
Sbjct: 188 AEG-----IEYLRVILRS-KLKTVHERI--------PLAGLSKLPSVPQIAKAFCDDAVG 233
Query: 310 LGSAS---PKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTL 366
L PK + +++ DE ++ K G++Y +A Q EEE++ N E PAF +FL L
Sbjct: 234 LRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDL 293
Query: 367 LGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKR 426
LGD + L+ F+ +R LD TG S+YTT++D EIMFHVST LP+T + QQL RKR
Sbjct: 294 LGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKR 353
Query: 427 HIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAF 486
HIGNDIV I+FQE + PF P I S+F H ++VV+ TP T +Y+V+V+ +D P F
Sbjct: 354 HIGNDIVAIIFQEENT-PFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTF 412
Query: 487 GPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
GP LP+ F +FR FLL K N E A + +F + RTR L +L
Sbjct: 413 GPPLPS-PPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 464
>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
Length = 1013
Score = 220 bits (561), Expect = 5e-57
Identities = 134/340 (39%), Positives = 187/340 (55%), Gaps = 18/340 (5%)
Query: 203 RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYR 262
R + LE+ + +Y KYF G+ HQN+ G D P +S+ ++ + YR
Sbjct: 83 RRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQ---RVPQYR 139
Query: 263 VIV-RTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTL 321
I+ R T + + LP P + LS + +L + R P++ + L
Sbjct: 140 AILWRKTGTQKI-------CLPYSPTKTLSVKSILSAMNLDKFEKGPR-EIFHPEIQKDL 191
Query: 322 LTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRA 381
L L+EQ S K G+L+ + GQ +++EM++N+ F +FL LLGD + LKG+ YR
Sbjct: 192 LVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRG 251
Query: 382 QLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQ--E 439
LDTK D+TG HS+YT YQ HEIMFHVSTMLPY+ N+QQ+ RKRHIGNDIVTIVFQ E
Sbjct: 252 GLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGE 311
Query: 440 PGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAA 499
S F P+ IRSHF H+F +VR + + YR+ + + P FGP LP F
Sbjct: 312 ESSPAFKPSMIRSHFTHIFALVRYN---QQNDNYRLKIFSEESVPLFGPPLPT-PPVFTD 367
Query: 500 NADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
+ +FR FLL K +NGE+A F RT ++ L
Sbjct: 368 HQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSL 407
Score = 30.8 bits (68), Expect = 7.0
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 2/88 (2%)
Query: 803 TTKQLLHLCLQDGGSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861
T ++LL L + G G P ++ R SQ P + S + +P+ + +
Sbjct: 909 TRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAST 968
Query: 862 TTAKPSVPSADSETPLTQDRPGSP-SGS 888
+ A P SA S+ DR GSP SGS
Sbjct: 969 SEANPEGHSASSDQDPVADREGSPVSGS 996
>gi|224809582 RAP1 GTPase activating protein isoform c [Homo
sapiens]
Length = 663
Score = 210 bits (535), Expect = 5e-54
Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%)
Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257
E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G
Sbjct: 70 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 123
Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317
R+++RT + RT I L P + + E V L PK
Sbjct: 124 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 177
Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377
R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+
Sbjct: 178 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 237
Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437
+R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF
Sbjct: 238 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 297
Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497
Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F
Sbjct: 298 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 355
Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
+F+ FLL K +N E A A +F + RTR L+ L
Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 397
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo
sapiens]
Length = 727
Score = 210 bits (535), Expect = 5e-54
Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%)
Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257
E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G
Sbjct: 134 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 187
Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317
R+++RT + RT I L P + + E V L PK
Sbjct: 188 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 241
Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377
R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+
Sbjct: 242 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 301
Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437
+R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF
Sbjct: 302 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 361
Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497
Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F
Sbjct: 362 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 419
Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
+F+ FLL K +N E A A +F + RTR L+ L
Sbjct: 420 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 461
>gi|224809573 RAP1 GTPase activating protein isoform b [Homo
sapiens]
Length = 681
Score = 210 bits (535), Expect = 5e-54
Identities = 132/342 (38%), Positives = 185/342 (54%), Gaps = 14/342 (4%)
Query: 198 EEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGT 257
E Q+ T+ LE + A YRK+F GKEH N++ +D +LG + SL+ + G
Sbjct: 70 EPLQSPTTKVKLE-CNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-----GD 123
Query: 258 LHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKV 317
R+++RT + RT I L P + + E V L PK
Sbjct: 124 QEHLRLLLRT-KCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKA 177
Query: 318 PRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFE 377
R ++T DE V+S K G++Y + GQ SEEE+++ E PAF++FL LG V+L+ F+
Sbjct: 178 SRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFK 237
Query: 378 SYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVF 437
+R LD TGT S+Y +++ EIMFHVST LPYT + QQL RKRHIGNDIV +VF
Sbjct: 238 GFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVF 297
Query: 438 QEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPF 497
Q+ + PF P I S+F H ++VV+A Y+V+V+ D P FGP LP F
Sbjct: 298 QDENT-PFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLP-DPAVF 355
Query: 498 AANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
+F+ FLL K +N E A A +F + RTR L+ L
Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETL 397
>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
[Homo sapiens]
Length = 2083
Score = 67.4 bits (163), Expect = 7e-11
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 12/236 (5%)
Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375
K+ R L LD + K+ + Y GQ + + N A+ F+ LG V L
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850
Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434
+ L K STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1851 HCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907
Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494
IV+ E ++ + I + F V +V+ P H + + + + + P FGP
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVI---YPMKNH-MFSIQIMKKPEVPFFGPLF---D 1959
Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLD 550
G + A A+N +A + R +YLQ + + + T+ +
Sbjct: 1960 GAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015
>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
[Homo sapiens]
Length = 2036
Score = 67.4 bits (163), Expect = 7e-11
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 12/236 (5%)
Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375
K+ R L LD + K+ + Y GQ + + N A+ F+ LG V L
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850
Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434
+ L K STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1851 HCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907
Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494
IV+ E ++ + I + F V +V+ P H + + + + + P FGP
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVI---YPMKNH-MFSIQIMKKPEVPFFGPLF---D 1959
Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLD 550
G + A A+N +A + R +YLQ + + + T+ +
Sbjct: 1960 GAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015
>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
Length = 1740
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)
Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368
L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG
Sbjct: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512
Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425
++ LK + + L D G +T +IM FH++T++P ++ + +K
Sbjct: 1513 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571
Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461
RH+GND V+IV+ + G + F TI+ F V ++V
Sbjct: 1572 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1606
>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
Length = 1807
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)
Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368
L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG
Sbjct: 1520 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1579
Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425
++ LK + + L D G +T +IM FH++T++P ++ + +K
Sbjct: 1580 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1638
Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461
RH+GND V+IV+ + G + F TI+ F V ++V
Sbjct: 1639 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1673
>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
Length = 1784
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)
Query: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368
L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG
Sbjct: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556
Query: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425
++ LK + + L D G +T +IM FH++T++P ++ + +K
Sbjct: 1557 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615
Query: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461
RH+GND V+IV+ + G + F TI+ F V ++V
Sbjct: 1616 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1650
>gi|118600961 akt substrate AS250 [Homo sapiens]
Length = 1873
Score = 64.3 bits (155), Expect = 6e-10
Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 15/247 (6%)
Query: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375
K+ R L LD + K+ + Y GQ + + +N+ A+ F+ LG V L
Sbjct: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
Query: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
Query: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494
IV+ E S+ + I + F V +++ P H + +A+++ + P FGP
Sbjct: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIII---YPMKNHMFF-IAITKKPEVPFFGPLF---D 1798
Query: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATN--EVTTTSLDSA 552
G + + + A +N +A + R YL+ + N EV T D A
Sbjct: 1799 GAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFE-DFA 1857
Query: 553 SRFGLPS 559
++ PS
Sbjct: 1858 AQVFSPS 1864
>gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens]
Length = 1989
Score = 41.2 bits (95), Expect = 0.005
Identities = 69/291 (23%), Positives = 124/291 (42%), Gaps = 25/291 (8%)
Query: 758 VLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPV-QDEVQGVTL----LPTTKQLLHLCL 812
V PP S FS +LSL P + + P+ Q V+G+ + LP L L
Sbjct: 547 VQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPP 606
Query: 813 QDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSAD 872
+D PP P EE E + + L SL+++ P T + + PS P +
Sbjct: 607 EDPEQPPKPPFADEEEEEEMLLREELL--KSLANKRAFKPEETS----SNSDPPSPPVLN 660
Query: 873 SETPLTQDRPGSPS---GSEDKGNPAPELRASFLPRT-LSLRNSISRIMSEAGSGTLEDE 928
+ P+ + S S+ + R LPRT +SL S +++ S D+
Sbjct: 661 NSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDS----DD 716
Query: 929 WQAISEIASTCNTI---LESLSREGQPIPESGD-PKGTPKSDAEPEPGNLSEKVSHLESM 984
++ E + + N++ LES+ +E + E PK PKS+ E +P E + + +
Sbjct: 717 SESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKI 776
Query: 985 -LRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQL 1034
R L+E++ + R +++++ + E + R+ + +KQ+
Sbjct: 777 EYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIG-RIAMVTKQV 826
>gi|210031154 zinc finger protein 541 [Homo sapiens]
Length = 1365
Score = 40.0 bits (92), Expect = 0.011
Identities = 52/220 (23%), Positives = 83/220 (37%), Gaps = 8/220 (3%)
Query: 750 SAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLH 809
+AP T LP + + ++++T + GAPDP + E L +
Sbjct: 325 AAPAALDTELPEEPCLPQKEPATDVFTAPNSRAAENGAPDPPEPEPDTALLQARSTA--- 381
Query: 810 LCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVP 869
C +GGS P L +T SQ S L + P P + + + +VP
Sbjct: 382 ECWPEGGSVPACLPLFRGQTVPASSQPSSHSFQWLRN-LPGCPKSKGNNVFVVHKPSAVP 440
Query: 870 SADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEW 929
S + GSPS E P L + LP +L + S+ S + ED+
Sbjct: 441 SREGSESGPGPSSGSPS-EESPPGPGGGLEDA-LPFPAALLRVPAEAPSDPRSASGEDDP 498
Query: 930 QAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEP 969
A ++ C++ L G+P + G +DA P
Sbjct: 499 CAPKKVKVDCDSFL--CQNPGEPGLQEAQKAGGLPADASP 536
>gi|221139926 NHS-like 1 [Homo sapiens]
Length = 1606
Score = 39.7 bits (91), Expect = 0.015
Identities = 53/175 (30%), Positives = 72/175 (41%), Gaps = 25/175 (14%)
Query: 736 LPSLRPEAAAQLLRSAPKVCVTVLPP-DESGRPRRSFSELYTLSL-QEPSRRGAPDPVQD 793
LPS P A L PK PP SG+P S L S +E SR P +
Sbjct: 1015 LPSSEPPPAPPL---DPKFMKDTRPPFTNSGQPESSRGSLRPPSTKEETSRPPMPLITTE 1071
Query: 794 EVQGVTLLPTTK-------QLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSD 846
+Q V L P K QL Q+ +P P + + FL S+NS + S S
Sbjct: 1072 ALQMVQLRPVRKNSGAEAAQLSERTAQEQRTPVAP-QYHLKPSAFLKSRNSTNEMESESQ 1130
Query: 847 EAPVLPNTTPDLLLATTAKPSVP-----SADSETPLTQDRPGSPSGSEDKGNPAP 896
A V + L T AK S +A+ P+++ PG+PS E + P+P
Sbjct: 1131 PASVTSS------LPTPAKSSSQGDHGSAAERGGPVSRS-PGAPSAGEAEARPSP 1178
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 39.7 bits (91), Expect = 0.015
Identities = 48/219 (21%), Positives = 81/219 (36%), Gaps = 21/219 (9%)
Query: 818 PPGPGDLAEERTEFLHSQNSLSPRS---------SLSDEAPVLPNTTPDLLLATTAKPSV 868
PP PG++ + E P SL AP++ + T A+P V
Sbjct: 363 PPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEV 422
Query: 869 -PSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLED 927
P+A + P P S PAP + + S N+ + + + AG+ E+
Sbjct: 423 GPAAPAMAPAPASAPAPASAPA----PAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEE 478
Query: 928 EWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRK 987
+ ++E E RE + E K + E E+ + E R+
Sbjct: 479 ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE-----ERTTRREEESRR 533
Query: 988 LQEDLQKEKADRAALEEEVRSLRHNN--RRLQAESESAA 1024
L+ + +EK ++ + E R+LR R Q + E A
Sbjct: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEA 572
Score = 30.8 bits (68), Expect = 7.0
Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 980 HLESMLRKLQEDLQKEKADRAALEEEVRS-LRHNNRRLQA 1018
HLE ++L+E QKE+ RAA+EE+ R L + R +A
Sbjct: 102 HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEA 141
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 39.3 bits (90), Expect = 0.020
Identities = 40/145 (27%), Positives = 63/145 (43%), Gaps = 18/145 (12%)
Query: 866 PSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRAS--FLPRTLSLRNSISRIMSEAGSG 923
P P A S+ P T D P PS + K + + R++ PRT S + + ++ S
Sbjct: 277 PPPPRASSKRPATADSP-KPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSS 335
Query: 924 TLEDEWQAISE--IASTCNTILESLSRE--------GQPIPESGDPKGTPKSDAEPEPGN 973
T ++ +A SE A + ES S + Q P + SD++ EP
Sbjct: 336 TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395
Query: 974 LSEKVSHLESMLRKLQEDLQKEKAD 998
+H + LR + EDLQ E++D
Sbjct: 396 -----NHSQGPLRSMVEDLQSEESD 415
>gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]
Length = 1522
Score = 39.3 bits (90), Expect = 0.020
Identities = 65/262 (24%), Positives = 98/262 (37%), Gaps = 43/262 (16%)
Query: 740 RPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPV-------Q 792
+P AAA L+ + +T LP D + P L LQ+ AP PV Q
Sbjct: 818 KPVAAATLVSQQAEEGLT-LPQDSAMTP--------PLPLQDTDLSSAPKPVAAATPVSQ 868
Query: 793 DEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSP-----RSSLSDE 847
+G+TL + L LQD G GP LA + L ++ +P + E
Sbjct: 869 QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQE 928
Query: 848 APVLPNTTPDLLLATTAKPSVPSADSETPLTQDRP------GSPSGSEDKGNPAPELRAS 901
P A P+VP + + QD P G+P +++ + + A
Sbjct: 929 VGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEAL 988
Query: 902 FLPRTLS-----LRNSISRIMSEA--------GSGTLEDEWQAIS-EIASTCNTILESLS 947
LP S + ++SR EA G G D Q + E+ + L+ L+
Sbjct: 989 SLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1048
Query: 948 REGQPIPESGDPKGTPKSDAEP 969
+E P G + P DA P
Sbjct: 1049 QEHGPRSALGGAREVP--DAPP 1068
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 39.3 bits (90), Expect = 0.020
Identities = 86/325 (26%), Positives = 119/325 (36%), Gaps = 68/325 (20%)
Query: 708 VTHVERFTFAETAGLRPGARLLRVCGQTLPSL-RPEAAAQLLRSAPKVCVTVLPPDESG- 765
V HVE A AGLR G + V G+ + L E +L+S KV ++ P + +
Sbjct: 1137 VWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSI 1196
Query: 766 --RPRRSFSELYTLSLQEPSRRGAPDPVQDE----------VQGVTLLPTTKQL--LHLC 811
P R S Y + S+R Q+ + +LL T++ L L+
Sbjct: 1197 KVGPARKGS--YKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRS 1254
Query: 812 LQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSA 871
L G S PG HS +SLSPRS TPD + + S S+
Sbjct: 1255 LSSGESGPGSP---------THS-HSLSPRSPTQGY-----RVTPDAVHSVGGNSSQSSS 1299
Query: 872 DSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQA 931
S + P SP+GS G+ P P+ S R AGS L
Sbjct: 1300 PSSSV-----PSSPAGS---GHTRPSSLHGLAPKLQRQYRSPRR--KSAGSIPL------ 1343
Query: 932 ISEIASTCNTILESLSREGQPIPESG-------------DPKG----TPKSDAEPEPGNL 974
S +A T + + S + P P SG P G PKS AEP L
Sbjct: 1344 -SPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKS-AEPPRSPL 1401
Query: 975 SEKVSHLESMLRKLQEDLQKEKADR 999
++V E + L +K R
Sbjct: 1402 LKRVQSAEKLAAALAASEKKLATSR 1426
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 38.9 bits (89), Expect = 0.026
Identities = 29/84 (34%), Positives = 39/84 (46%), Gaps = 7/84 (8%)
Query: 689 ALPRDGQG---RLGFEVDAEG--FVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEA 743
A P QG GF + G FV V + + A GLRPG ++L V G + L E
Sbjct: 5 ATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRER 64
Query: 744 AAQLLRSAPKV--CVTVLPPDESG 765
+L R P+V + VLP + G
Sbjct: 65 LVRLARRCPRVPPSLGVLPAPDGG 88
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 38.9 bits (89), Expect = 0.026
Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 38/156 (24%)
Query: 924 TLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDA---EPEPGNLSEKVSH 980
TL+D+ + + +++ E LS+ + + E+ D T A +S+ +S
Sbjct: 518 TLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ 577
Query: 981 LESMLRKLQED---------------------LQKEKADRA--------------ALEEE 1005
LES+ R+LQE L+ E+ DR +L+EE
Sbjct: 578 LESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEE 637
Query: 1006 VRSLRHNNRRLQAESESAATRLLLASKQLGSPTADL 1041
V+ L+HN +++ E + A L + K+ + DL
Sbjct: 638 VKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDL 673
>gi|21536357 TBP-associated factor 6 isoform delta [Homo sapiens]
Length = 667
Score = 38.9 bits (89), Expect = 0.026
Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%)
Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787
LL+ C L LRP PPD R F L L + + A
Sbjct: 417 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 458
Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845
+Q + T L T+ L L P PG L + L Q +S R++
Sbjct: 459 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 516
Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905
AP P+ P + ++ S PS L+ PGS S + P
Sbjct: 517 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 561
Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965
T ++ S+ I+ + T A S S I+ SL P +G+ KG P S
Sbjct: 562 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 613
Query: 966 DAEPEP 971
P P
Sbjct: 614 HPSPVP 619
Score = 32.0 bits (71), Expect = 3.1
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79
P+ P P P+ G L G +AG++ PP P +P+A S
Sbjct: 617 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 662
>gi|5032147 TBP-associated factor 6 isoform alpha [Homo sapiens]
Length = 677
Score = 38.9 bits (89), Expect = 0.026
Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%)
Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787
LL+ C L LRP PPD R F L L + + A
Sbjct: 427 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 468
Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845
+Q + T L T+ L L P PG L + L Q +S R++
Sbjct: 469 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 526
Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905
AP P+ P + ++ S PS L+ PGS S + P
Sbjct: 527 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 571
Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965
T ++ S+ I+ + T A S S I+ SL P +G+ KG P S
Sbjct: 572 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 623
Query: 966 DAEPEP 971
P P
Sbjct: 624 HPSPVP 629
Score = 32.0 bits (71), Expect = 3.1
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79
P+ P P P+ G L G +AG++ PP P +P+A S
Sbjct: 627 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 672
>gi|21536359 TBP-associated factor 6 isoform alpha [Homo sapiens]
Length = 677
Score = 38.9 bits (89), Expect = 0.026
Identities = 60/246 (24%), Positives = 84/246 (34%), Gaps = 45/246 (18%)
Query: 728 LLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGA 787
LL+ C L LRP PPD R F L L + + A
Sbjct: 427 LLKHCAPVLAKLRP------------------PPDNQDAYRAEFGSLGPLLCSQVVKARA 468
Query: 788 PDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPG--PGDLAEERTEFLHSQNSLSPRSSLS 845
+Q + T L T+ L L P PG L + L Q +S R++
Sbjct: 469 QAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAA-- 526
Query: 846 DEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPR 905
AP P+ P + ++ S PS L+ PGS S + P
Sbjct: 527 --APPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTS-------------PV 571
Query: 906 TLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKS 965
T ++ S+ I+ + T A S S I+ SL P +G+ KG P S
Sbjct: 572 TTTV-PSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSL-------PPTGEGKGGPTS 623
Query: 966 DAEPEP 971
P P
Sbjct: 624 HPSPVP 629
Score = 32.0 bits (71), Expect = 3.1
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Query: 35 PLTPHTFEPRPVRGPLLRSGS-DAGEARPPTPASPRARAHSHEEAS 79
P+ P P P+ G L G +AG++ PP P +P+A S
Sbjct: 627 PVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGS 672
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 38.9 bits (89), Expect = 0.026
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 14/215 (6%)
Query: 832 LHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSG---- 887
L N SPR LS V T+P LL ++ + PSA S++ +T +R SPS
Sbjct: 2375 LSGANLTSPRVPLSAYERVSGRTSPPLLDRARSR-TPPSAPSQSRMTSERAPSPSSRMGQ 2433
Query: 888 --SEDKGNPAPELRASFLPRTLS--LRNSISRIMSEAGSGTLEDEWQAISEIASTCNTIL 943
S+ PA + S +P S R I++ AGS +L A + ++ + +
Sbjct: 2434 APSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGM 2493
Query: 944 ESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALE 1003
S+ G P + G+P P S +P L+ E R + ++
Sbjct: 2494 LSVPAPGVPHSDVGEP---PASTGAQQPSALAALQPAKER--RSSSSSSSSSSSSSSSSS 2548
Query: 1004 EEVRSLRHNNRRLQAESESAATRLLLASKQLGSPT 1038
S + +E S + +A K++ SPT
Sbjct: 2549 SSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPT 2583
Score = 38.1 bits (87), Expect = 0.044
Identities = 44/173 (25%), Positives = 69/173 (39%), Gaps = 29/173 (16%)
Query: 816 GSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEA---PVLPNTTPDLLLATTAKPSVPSAD 872
G+PP G + + ++ S++P+ E+ P L + TP + + P P
Sbjct: 847 GTPPRQGSITSPQA----NEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSP--PRVK 900
Query: 873 SETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQAI 932
S TP Q SPS S +P P+++A PR S S S S S T +++
Sbjct: 901 SSTPPRQ----SPSRSS---SPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSV 953
Query: 933 SEIASTCNTILESLSREGQPIPE-------------SGDPKGTPKSDAEPEPG 972
S ++ + +L S G P+ SG PK A+ PG
Sbjct: 954 SPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG 1006
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,015,574
Number of Sequences: 37866
Number of extensions: 2754823
Number of successful extensions: 14552
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 371
Number of HSP's that attempted gapping in prelim test: 12261
Number of HSP's gapped (non-prelim): 2632
length of query: 1042
length of database: 18,247,518
effective HSP length: 112
effective length of query: 930
effective length of database: 14,006,526
effective search space: 13026069180
effective search space used: 13026069180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.