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Search of human proteins with 20336246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
(913 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 1974 0.0
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 1102 0.0
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 1092 0.0
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 1045 0.0
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 1035 0.0
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 835 0.0
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 835 0.0
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 835 0.0
gi|4505579 furin preproprotein [Homo sapiens] 673 0.0
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 644 0.0
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 608 e-174
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 574 e-163
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 477 e-134
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 457 e-128
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 156 7e-38
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 156 7e-38
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 156 7e-38
gi|108773804 Fraser syndrome 1 [Homo sapiens] 139 1e-32
gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Ho... 81 4e-15
gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Ho... 76 1e-13
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 70 7e-12
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 68 4e-11
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 62 2e-09
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 62 2e-09
gi|84490388 R-spondin1 [Homo sapiens] 60 1e-08
gi|122937440 multiple EGF-like-domains 9 [Homo sapiens] 59 2e-08
gi|54792098 erbB-2 isoform b [Homo sapiens] 59 3e-08
gi|54792096 erbB-2 isoform a [Homo sapiens] 59 3e-08
gi|143770880 laminin, beta 4 [Homo sapiens] 57 6e-08
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 56 1e-07
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 1974 bits (5113), Expect = 0.0
Identities = 913/913 (100%), Positives = 913/913 (100%)
Query: 1 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 60
MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
Sbjct: 1 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 60
Query: 61 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 120
NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
Sbjct: 61 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 120
Query: 121 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 180
AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
Sbjct: 121 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 180
Query: 181 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 240
LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
Sbjct: 181 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 240
Query: 241 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 300
GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
Sbjct: 241 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 300
Query: 301 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 360
RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
Sbjct: 301 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 360
Query: 361 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 420
SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
Sbjct: 361 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 420
Query: 421 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 480
AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
Sbjct: 421 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 480
Query: 481 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 540
PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
Sbjct: 481 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 540
Query: 541 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 600
LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
Sbjct: 541 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 600
Query: 601 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 660
QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
Sbjct: 601 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 660
Query: 661 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 720
YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
Sbjct: 661 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 720
Query: 721 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 780
VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
Sbjct: 721 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 780
Query: 781 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 840
DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
Sbjct: 781 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 840
Query: 841 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV 900
SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV
Sbjct: 841 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV 900
Query: 901 LQQLCCKTCTFQG 913
LQQLCCKTCTFQG
Sbjct: 901 LQQLCCKTCTFQG 913
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 1102 bits (2851), Expect = 0.0
Identities = 525/932 (56%), Positives = 655/932 (70%), Gaps = 33/932 (3%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + GKLKEWSL+LYGT+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
Query: 602 PY----------------SPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGC 645
PY +P E PK S+VE P D+ EDY G C PEC + GC
Sbjct: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDE---EDYTGVCHPECGDKGC 691
Query: 646 DGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQC 704
DGP D C +C+H+ +R CVS CP G++ +RCR+C CE+C QC
Sbjct: 692 DGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQC 751
Query: 705 MSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNCTECRDGLSLQ 763
+SC+ G++ ++E N+CVT CP G Y D + C KC +CK C E CT C++G SL
Sbjct: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
Query: 764 GSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSIS 821
C CE G YF+ + C CH C TC G G + CI+C + + D +CV +C
Sbjct: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
Query: 822 YYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESW 881
+Y + +K C++CD +CL+C G +NC+ C +G+ Q+G C S
Sbjct: 872 FYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGF------TQLGTSCITNHTCSN 924
Query: 882 AEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG 913
A+ FC +VK N LC+RK+ Q CC+TC G
Sbjct: 925 ADETFCEMVKSNRLCERKLFIQFCCRTCLLAG 956
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 1092 bits (2824), Expect = 0.0
Identities = 524/942 (55%), Positives = 654/942 (69%), Gaps = 40/942 (4%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + GKLKEWSL+LYGT+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
Query: 602 PY----------------SPTNEFPKVERFRYSRVEDPTD--DYGTEDYAGP-------- 635
PY +P E PK S+VE P D DY + G
Sbjct: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDEEDYTAQSTPGSANILQTSV 694
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCE 694
C PEC + GCDGP D C +C+H+ +R CVS CP G++ +RCR+C CE
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 695 SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNC 753
+C QC+SC+ G++ ++E N+CVT CP G Y D + C KC +CK C E C
Sbjct: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
Query: 754 TECRDGLSLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMED 811
T C++G SL C CE G YF+ + C CH C TC G G + CI+C + + D
Sbjct: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
Query: 812 GRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGA 871
+CV +C +Y + +K C++CD +CL+C G +NC+ C +G+ Q+G
Sbjct: 875 WKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGF------TQLGT 927
Query: 872 ICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG 913
C S A+ FC +VK N LC+RK+ Q CC+TC G
Sbjct: 928 SCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG 969
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 1045 bits (2702), Expect = 0.0
Identities = 495/856 (57%), Positives = 613/856 (71%), Gaps = 26/856 (3%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + GKLKEWSL+LYGT+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
Query: 602 PY----------------SPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGC 645
PY +P E PK S+VE P D+ EDY G C PEC + GC
Sbjct: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDE---EDYTGVCHPECGDKGC 691
Query: 646 DGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQC 704
DGP D C +C+H+ +R CVS CP G++ +RCR+C CE+C QC
Sbjct: 692 DGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQC 751
Query: 705 MSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNCTECRDGLSLQ 763
+SC+ G++ ++E N+CVT CP G Y D + C KC +CK C E CT C++G SL
Sbjct: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
Query: 764 GSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSIS 821
C CE G YF+ + C CH C TC G G + CI+C + + D +CV +C
Sbjct: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
Query: 822 YYFDHSSENGYKSCKK 837
+Y + +K C++
Sbjct: 872 FYPEEMPGLPHKVCRR 887
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 1035 bits (2675), Expect = 0.0
Identities = 494/866 (57%), Positives = 612/866 (70%), Gaps = 33/866 (3%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + GKLKEWSL+LYGT+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
Query: 602 PY----------------SPTNEFPKVERFRYSRVEDPTD--DYGTEDYAGP-------- 635
PY +P E PK S+VE P D DY + G
Sbjct: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDEEDYTAQSTPGSANILQTSV 694
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCE 694
C PEC + GCDGP D C +C+H+ +R CVS CP G++ +RCR+C CE
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 695 SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNC 753
+C QC+SC+ G++ ++E N+CVT CP G Y D + C KC +CK C E C
Sbjct: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
Query: 754 TECRDGLSLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMED 811
T C++G SL C CE G YF+ + C CH C TC G G + CI+C + + D
Sbjct: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
Query: 812 GRCVQSCSISYYFDHSSENGYKSCKK 837
+CV +C +Y + +K C++
Sbjct: 875 WKCVPACGEGFYPEEMPGLPHKVCRR 900
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 835 bits (2158), Expect = 0.0
Identities = 391/587 (66%), Positives = 470/587 (80%), Gaps = 2/587 (0%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKL 588
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + G L
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGNL 622
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 835 bits (2158), Expect = 0.0
Identities = 391/588 (66%), Positives = 471/588 (80%), Gaps = 2/588 (0%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLK 589
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + G L+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGDLE 623
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 835 bits (2158), Expect = 0.0
Identities = 391/588 (66%), Positives = 471/588 (80%), Gaps = 2/588 (0%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
Query: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
Query: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLK 589
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + G L+
Sbjct: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGDLE 623
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 673 bits (1736), Expect = 0.0
Identities = 361/724 (49%), Positives = 448/724 (61%), Gaps = 73/724 (10%)
Query: 15 LLCVLALLGGCLLPVCRT---RVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDY 71
LL V+A G +L +V+TN WAV+I GG AN +A K+GF+N+GQI DY
Sbjct: 7 LLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--FGDY 64
Query: 72 YHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKW 131
YHF+H KRS+ R HS + EP+V+W++QQV K+RTKRD DPK+
Sbjct: 65 YHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPT------DPKF 118
Query: 132 PSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASC 191
P WY+ + Q D+N++ AW +GYTG IVV+ILDDGIE+ HPDL NYD AS
Sbjct: 119 PQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASF 173
Query: 192 DVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTD 251
DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+A+NA+IGGVRMLDG+VTD
Sbjct: 174 DVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTD 233
Query: 252 MVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 311
VEA+S+ NP H+HIYSASWGP+DDGKTVDGPA L +AF GV GR GLGS+FVWAS
Sbjct: 234 AVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWAS 293
Query: 312 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 371
GNGGR D C+CDGYTNSIYT+SISS + G PWY E CSSTLATTYSSG +K+I+T
Sbjct: 294 GNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVT 353
Query: 372 TDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKT 431
TDLRQ+CT++HTGTSASAP+AAGIIAL LEAN LTWRD+QH++V+TS+ HLNANDW T
Sbjct: 354 TDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWAT 413
Query: 432 NAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKA 491
N G KVSH YG+GL+DA AMV A+ WTTV Q C+ + K I VR A
Sbjct: 414 NGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTA 473
Query: 492 SGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKN 551
C PN H+ LEH R+T+++ RRGDLAI+L SP GTRS LLA R D+S +GF +
Sbjct: 474 --CLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFND 530
Query: 552 WEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPK 611
W FMT H W E +G+WVLE+ +T S+ N+ G L +++LVLYGT+ +
Sbjct: 531 WAFMTTHSWDEDPSGEWVLEIENT-SEANNY---GTLTKFTLVLYGTAPEGL-------- 578
Query: 612 VERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICV 671
P PE S GC C+ + + CV
Sbjct: 579 -----------------------PVPPESS--GCKTLTSSQA--CVVCEEGFSLHQKSCV 611
Query: 672 SSCPPG--------HYHADK-------KRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE 716
CPPG HY + C C +C +C G C+SC L+
Sbjct: 612 QHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPV 671
Query: 717 TNSC 720
+C
Sbjct: 672 EQTC 675
Score = 52.8 bits (125), Expect = 1e-06
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 12/85 (14%)
Query: 789 CATCAGAGADGCINCTEGYFMEDGRCVQSCSISYY-----FDHSSENGYKS-----CKKC 838
C T + A C+ C EG+ + CVQ C + +S+EN ++ C C
Sbjct: 587 CKTLTSSQA--CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPC 644
Query: 839 DISCLTCNGPGFKNCTSCPSGYLLD 863
SC TC GP +C SCPS LD
Sbjct: 645 HASCATCQGPALTDCLSCPSHASLD 669
Score = 50.1 bits (118), Expect = 1e-05
Identities = 26/79 (32%), Positives = 29/79 (36%), Gaps = 16/79 (20%)
Query: 741 SENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG--------RYFNGQD--------CQP 784
S CKT T C C +G SL C C G Y D C P
Sbjct: 584 SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAP 643
Query: 785 CHRFCATCAGAGADGCINC 803
CH CATC G C++C
Sbjct: 644 CHASCATCQGPALTDCLSC 662
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 644 bits (1660), Expect = 0.0
Identities = 301/436 (69%), Positives = 354/436 (81%), Gaps = 2/436 (0%)
Query: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
Query: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
Query: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Query: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
Query: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
Query: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
Query: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
Query: 422 GHLNANDWKTNAAGFK 437
HL A+DWK N AG K
Sbjct: 456 AHLKASDWKVNGAGHK 471
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 608 bits (1568), Expect = e-174
Identities = 320/693 (46%), Positives = 414/693 (59%), Gaps = 40/693 (5%)
Query: 31 RTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGT 90
R +Y + WAV+++ G E R+A K+GF+N+G I Y+H H +++S+ G
Sbjct: 30 RAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGH 89
Query: 91 HSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDM 150
+ PKV+W QQQ +++R KR DP + WYM+ Q D+
Sbjct: 90 RLHLKKNPKVQWFQQQTLQRRVKRSVVVP-------TDPWFSKQWYMNSE-----AQPDL 137
Query: 151 NIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNEN 210
+I AW +G +G+ IVV++LDDGIE+ HPDL NYD LAS D N D DP PRY S EN
Sbjct: 138 SILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKEN 197
Query: 211 KHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSA 270
+HGTRCAGEVAA ANN C VG+AFNA+IGGVRMLDG +TD++EA+S+S PQH+HIYSA
Sbjct: 198 RHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSA 257
Query: 271 SWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSI 330
SWGP+DDG+TVDGP LTR+AF GV GR GLG++F+WASGNGG D+C+CDGYTNSI
Sbjct: 258 SWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSI 317
Query: 331 YTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAP 390
+T+S+ ST + G+ PWY E C+STL TTYSSG + D +I+TTDL CTD HTGTSASAP
Sbjct: 318 HTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAP 377
Query: 391 MAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAE 450
+AAG+IALALEANPFLTWRD+QH++VR S+ HL A DW+TN G +VSH YG+GL+DA
Sbjct: 378 LAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAG 437
Query: 451 AMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVV 510
+V A W Q C + I P +R S C+ N + LEHV
Sbjct: 438 LLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRE--NVSACAGLHN-SIRSLEHVQA 494
Query: 511 RITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVL 570
++T+++ RRGDL I LTSP GTRS L+A R D S EG+ NW FM+ H W E G W L
Sbjct: 495 QLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTL 554
Query: 571 EVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTE 630
+ + G L ++L+LYGT+ PT T
Sbjct: 555 GL----ENKGYYFNTGTLYRYTLLLYGTA-----------------EDMTARPTGPQVTS 593
Query: 631 DYAGPCDPECSEVGCDGPGPDHCNDCLHYY-YKLKNNTRICVSSCPPGHYHADKKR-CRK 688
D E CDGP CL Y + N+TR+ + PGH A R C
Sbjct: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAG--PGHTAAPALRVCSS 651
Query: 689 CAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV 721
C +C +C G C SC L+++ SC+
Sbjct: 652 CHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
Score = 40.0 bits (92), Expect = 0.010
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 3/53 (5%)
Query: 826 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD--LGMCQMGAICKDA 876
H++ + C C SC TC G ++CTSCP LD G C MG D+
Sbjct: 640 HTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSC-MGPTTPDS 691
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 574 bits (1479), Expect = e-163
Identities = 299/629 (47%), Positives = 396/629 (62%), Gaps = 22/629 (3%)
Query: 33 RVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHS 92
R + N WA +I GG A+ IA + G+ +GQIG+L+++Y F H +RS S+
Sbjct: 29 RQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITK 88
Query: 93 FISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMN 151
+S + +V W +QQ K+R+KR A + FNDP W WY+ + T D++
Sbjct: 89 RLSDDDRVIWAEQQYEKERSKRSALRDSALNL-FNDPMWNQQWYLQDTRMTAALPKLDLH 147
Query: 152 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK 211
+ W++G TGK +V+T+LDDG+E H D+ NYD AS D N ND DP PRYD +NENK
Sbjct: 148 VIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENK 207
Query: 212 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS 271
HGTRCAGE+A ANN C VG+A+N+K+GG+RMLDG VTD +EA S+ FNP HV IYSAS
Sbjct: 208 HGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSAS 267
Query: 272 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY 331
WGP+DDGKTV+GP L ++AFE GV+ GR+G GS+FVWASGNGGR D+C CDGYT+SIY
Sbjct: 268 WGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIY 327
Query: 332 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM 391
TISISS ++ G PWY E+CSSTLAT+YSSG+ D++I + DL CT+ HTGTSASAP+
Sbjct: 328 TISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPL 387
Query: 392 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHL-NANDWKTNAAGFKVSHLYGFGLMDAE 450
AAGI ALALEANP LTWRD+QH++V TS L N WK N AG V+ +GFGL++A+
Sbjct: 388 AAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAK 447
Query: 451 AMV--MEAEKWTTVPRQHVC-VESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEH 507
A+V + W +VP + C V+ D + + ++ N V C N + LEH
Sbjct: 448 ALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENA-IKSLEH 506
Query: 508 VVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGD 567
V TI + RRGDL + LTS +GT + LLA R D S GFKNW+FM++H WGE G
Sbjct: 507 VQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGT 566
Query: 568 WVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQP------------YSPTNEFPKVERF 615
W L + D +++N G++ W L+L+GTS QP + N+ VE+
Sbjct: 567 WTLRITDMSGRIQN---EGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKM 623
Query: 616 RYSRVEDPTDDYGTEDYAGPCDPECSEVG 644
E PT + E+ P S VG
Sbjct: 624 VDPGEEQPTQENPKENTLVSKSPSSSSVG 652
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 477 bits (1228), Expect = e-134
Identities = 262/578 (45%), Positives = 352/578 (60%), Gaps = 15/578 (2%)
Query: 34 VYTNHWAVKI-AGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHS 92
V+TNH+ V++ GG +A ++A+++GF + ++ + YHFYH+ K S
Sbjct: 29 VFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQ 87
Query: 93 FISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMN 151
+ +P+V+ QQ R KR Y NDP + WY+ + D+N
Sbjct: 88 QLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLN 147
Query: 152 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK 211
+ AW+ GYTGK + + I+DDGI+ HPDL NY+A AS D + ND P PRY N
Sbjct: 148 VAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNS 207
Query: 212 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGD-VTDMVEAKSVSFNPQHVHIYSA 270
HGTRCAGEV+AAANN+ C VG+A+N+K+ G+RMLD +TD++EA S+S PQ + IYSA
Sbjct: 208 HGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSA 267
Query: 271 SWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSI 330
SWGP D+GKTVDGP LT QA +GV GR G GS++VWASG+GG S D C+CDGY +S+
Sbjct: 268 SWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSM 326
Query: 331 YTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKK--IITTDLRQRCTDNHTGTSAS 388
+TISI+S G+ Y E CSSTLA+T+S+G + + + TTDL CT H+GTSA+
Sbjct: 327 WTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAA 386
Query: 389 APMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLN--ANDWKTNAAGFKVSHLYGFGL 446
AP AAG+ ALALEAN LTWRD+QH+ V TS+ L+ + W+ N G + +HL+G+G+
Sbjct: 387 APEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGV 446
Query: 447 MDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLE 506
+DA AMV A+ W TVP + CV + + + I + C N V YLE
Sbjct: 447 LDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKEN-FVRYLE 505
Query: 507 HVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR-LFDHSMEGFKNWEFMTIHCWGERAA 565
HV IT+ RRGDL I +TSP GT+S LL+ R D S GF W FMT H WGE A
Sbjct: 506 HVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDAR 565
Query: 566 GDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY 603
G W LE+ S + G LKEW+L+L+GT PY
Sbjct: 566 GTWTLELGFVGSAPQK----GVLKEWTLMLHGTQSAPY 599
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 457 bits (1177), Expect = e-128
Identities = 248/598 (41%), Positives = 349/598 (58%), Gaps = 30/598 (5%)
Query: 49 EANRIASKYGFINIGQIGALKDYYHFY----HSRTIKRSVISSRGTHSFISMEPKVEWIQ 104
+A+ +A G +N G+IG L+ +Y F H ++ I + + ++ V W
Sbjct: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
Query: 105 QQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKN 164
+Q + +R KR S +FNDPK+P W+++ N D+N+ G W+R TG+
Sbjct: 132 EQRLLRRAKR--------SVHFNDPKYPQQWHLN---NRRSPGRDINVTGVWERNVTGRG 180
Query: 165 IVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAA 224
+ V ++DDG+E T D+ NY S D+N ND DPMP D N N HGTRCAGE+AA
Sbjct: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
Query: 225 NNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGP 284
NNS C VG+A+ ++I G+R+LDG +TD +EA + + + Q IYS SWGPDDDGKTVDGP
Sbjct: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
Query: 285 APLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKK 344
L + A ++GV GR+G GS+FV ASGNGG+ D+C+ DGY NSIYT++I + E G+
Sbjct: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
Query: 345 PWYLEECSSTLATTYSSGESYDKKIITTDLRQR----CTDNHTGTSASAPMAAGIIALAL 400
P+Y EEC+S LA T+S G+ + I+TTD + CT+ HTGTSA+AP+AAG+IAL L
Sbjct: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
Query: 401 EANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWT 460
+ P LTWRDVQH+IV T+ +W TN AGF SH +GFGL++A +V A+ WT
Sbjct: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
Query: 461 TVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRG 520
+VP V ++ K I + + D + LEHV V ++ITHPRRG
Sbjct: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
Query: 521 DLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLR 580
L + L PSG S + A R D GF +W F T+ CWGERA G + L + D +
Sbjct: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE-- 598
Query: 581 NFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDP 638
+F+ G L++W L LYG+ + +R S + + Y +D+A PC P
Sbjct: 599 SFQV-GILRQWQLTLYGSVWSAVDIRDR----QRLLESAM---SGKYLHDDFALPCPP 648
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 156 bits (395), Expect = 7e-38
Identities = 88/248 (35%), Positives = 115/248 (46%), Gaps = 18/248 (7%)
Query: 626 DYGTEDYAG--PCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HAD 682
+Y ED G PC +C C GP D C C L N T CV CP G+Y D
Sbjct: 452 EYWDEDAPGCKPCHVKCFH--CMGPAEDQCQTC-PMNSLLLNTT--CVKDCPEGYYADED 506
Query: 683 KKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSE 742
RC C +C +C G H QC SC+ G+F + C+ C +G Y D C +C+
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNR 564
Query: 743 NCKTCTEFH--NCTECRDGLSLQGSR--CSVSCEDGRYF--NGQDCQPCHRFCATCAGAG 796
+CK C +C C L S+ C SC D Y + Q C+ CH C C G G
Sbjct: 565 SCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKG 624
Query: 797 ADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC 856
A C++C Y + G C C + Y E +C+KC SC+ C GPG KNCT C
Sbjct: 625 ALNCLSCVWSYHLMGGICTSDCLVGEY--RVGEGEKFNCEKCHESCMECKGPGAKNCTLC 682
Query: 857 PSGYLLDL 864
P+ +L +
Sbjct: 683 PANLVLHM 690
Score = 141 bits (355), Expect = 3e-33
Identities = 86/300 (28%), Positives = 114/300 (38%), Gaps = 63/300 (21%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLH------------------YYYKLK 664
P Y + PC +C E C GP D C CL YY K
Sbjct: 351 PRGFYADSHHCVPCHKDCLE--CSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQT 408
Query: 665 NNTRICVSSC-------------------------------PPGHYHADKKRCRKCAPNC 693
R C SC P ++ D C+ C C
Sbjct: 409 KECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKC 468
Query: 694 ESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHN- 752
C G DQC +C L T CV CP+G Y D N C C +C+TC H+
Sbjct: 469 FHCMGPAEDQCQTCPMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSR 526
Query: 753 -CTECRDGLSLQGSRCSVSCEDGRYFNGQD--CQPCHRFCATCAGAGADGCINCTEGYFM 809
C CR G G C + C +G Y + C+ C+R C C G C++C +F+
Sbjct: 527 QCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFL 586
Query: 810 --EDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMC 867
G C +SC YY + S++ +C++C +C C G G NC SC Y L G+C
Sbjct: 587 LRSKGECHRSCPDHYYVEQSTQ----TCERCHPTCDQCKGKGALNCLSCVWSYHLMGGIC 642
Score = 135 bits (340), Expect = 2e-31
Identities = 79/254 (31%), Positives = 116/254 (45%), Gaps = 18/254 (7%)
Query: 633 AGPCDPECSEVGCDGPGPDHCNDC-LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAP 691
+G C+ C+E G D C C + + L + C S CP G Y A+ C +C+
Sbjct: 218 SGSCE-NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY-AEDGICERCSS 275
Query: 692 NCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
C +C G+ C SC+ G+ L+ C +CP+ + +C+ C E C+ C
Sbjct: 276 PCRTCEGN-ATNCHSCEGGHVLHHGV--CQENCPERHV--AVEGVCKHCPEMCQDCIHEK 330
Query: 752 NCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTE-GYFME 810
C EC L C SC G Y + C PCH+ C C+G AD C C E + +
Sbjct: 331 TCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWVLY 390
Query: 811 DGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD-LGMCQM 869
DG C++ C Y++ + K C+ C SCLTC+ G CT+C G +++ G C
Sbjct: 391 DGLCLEECPAGTYYEKQT----KECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMA 444
Query: 870 GAICKDATEESWAE 883
C + E W E
Sbjct: 445 NEKC--SPSEYWDE 456
Score = 113 bits (283), Expect = 7e-25
Identities = 90/299 (30%), Positives = 120/299 (40%), Gaps = 40/299 (13%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HA 681
P Y CD CS CD G C C ++ L + CV C PG Y
Sbjct: 65 PEKTYSEAVECKACDSNCSS--CDQNG---CYWCEEGFFLLGGS---CVRKCGPGFYGDQ 116
Query: 682 DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHC----PDGSYQDTKKNLC 737
+ C C CE+C G D+C SC+ G L CV H +G + +
Sbjct: 117 EMGECESCHRACETCTGPGHDECSSCQEG--LQLLRGMCV-HATKTQEEGKFWNDILRKL 173
Query: 738 RKCSENCKTCTEFHN-CTECRDGLSLQGSRCSVSCEDGRY--FNGQDCQPCHRFCATCAG 794
+ C +CKTC CT C G L C SC G + C+ C CA C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC-- 231
Query: 795 AGADGCINCT----EGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGF 850
+GAD C C F+ +GRC C Y +E+G C++C C TC G
Sbjct: 232 SGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY----AEDGI--CERCSSPCRTCEG-NA 284
Query: 851 KNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTC 909
NC SC G++L G+CQ ++ E A G C + +CQ + + CK C
Sbjct: 285 TNCHSCEGGHVLHHGVCQ-----ENCPERHVAVEGVCKHCPE--MCQ-DCIHEKTCKEC 335
Score = 102 bits (254), Expect = 2e-21
Identities = 61/211 (28%), Positives = 83/211 (39%), Gaps = 18/211 (8%)
Query: 623 PTDDYGTEDY--AGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYH 680
P Y ED C C C+G C+ C +++L C+ C G+Y
Sbjct: 498 PEGYYADEDSNRCAHCHSSCRT--CEGRHSRQCHSCRPGWFQLGKE---CLLQCREGYY- 551
Query: 681 ADKK--RCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCR 738
AD RC +C +C+ C G C+SC +FL C CPD Y + C
Sbjct: 552 ADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611
Query: 739 KCSENCKTC--TEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ----DCQPCHRFCATC 792
+C C C NC C L G C+ C G Y G+ +C+ CH C C
Sbjct: 612 RCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMEC 671
Query: 793 AGAGADGCINCTEG--YFMEDGRCVQSCSIS 821
G GA C C M++ C+ C+ S
Sbjct: 672 KGPGAKNCTLCPANLVLHMDESHCLHCCNTS 702
Score = 96.7 bits (239), Expect = 9e-20
Identities = 63/208 (30%), Positives = 91/208 (43%), Gaps = 37/208 (17%)
Query: 714 NEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCED 773
N + C CP+ +Y + + C+ C NC +C + + C C +G L G C C
Sbjct: 54 NRFDHHCYKTCPEKTYSEAVE--CKACDSNCSSCDQ-NGCYWCEEGFFLLGGSCVRKCGP 110
Query: 774 GRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENG 831
G Y + + +C+ CHR C TC G G D C +C EG + G CV + + E G
Sbjct: 111 GFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATK-------TQEEG 163
Query: 832 ------YKSCKKCDISCLTCNGPGFKNCTSCPSG-YLLD---LGMCQMG-------AICK 874
+ + C SC TCNG CTSCP G YLL + C G C+
Sbjct: 164 KFWNDILRKLQPCHSSCKTCNGSA-TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 875 DATEESWAEGGFCMLVKKNNLCQRKVLQ 902
+ TE C + +LC++ +Q
Sbjct: 223 NCTEA-------CAICSGADLCKKCQMQ 243
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 156 bits (395), Expect = 7e-38
Identities = 88/248 (35%), Positives = 115/248 (46%), Gaps = 18/248 (7%)
Query: 626 DYGTEDYAG--PCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HAD 682
+Y ED G PC +C C GP D C C L N T CV CP G+Y D
Sbjct: 452 EYWDEDAPGCKPCHVKCFH--CMGPAEDQCQTC-PMNSLLLNTT--CVKDCPEGYYADED 506
Query: 683 KKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSE 742
RC C +C +C G H QC SC+ G+F + C+ C +G Y D C +C+
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNR 564
Query: 743 NCKTCTEFH--NCTECRDGLSLQGSR--CSVSCEDGRYF--NGQDCQPCHRFCATCAGAG 796
+CK C +C C L S+ C SC D Y + Q C+ CH C C G G
Sbjct: 565 SCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKG 624
Query: 797 ADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC 856
A C++C Y + G C C + Y E +C+KC SC+ C GPG KNCT C
Sbjct: 625 ALNCLSCVWSYHLMGGICTSDCLVGEY--RVGEGEKFNCEKCHESCMECKGPGAKNCTLC 682
Query: 857 PSGYLLDL 864
P+ +L +
Sbjct: 683 PANLVLHM 690
Score = 140 bits (354), Expect = 4e-33
Identities = 87/302 (28%), Positives = 119/302 (39%), Gaps = 67/302 (22%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPG-HYHA 681
P Y + PC +C E C GP D C CL + L + +C+ CP G +Y
Sbjct: 351 PRGFYADSRHCVPCHKDCLE--CSGPKADDCELCLESSWVLYDG--LCLEECPAGTYYEK 406
Query: 682 DKKRCRKC-------------------------------------------APNCESC-- 696
+ K CR C AP C+ C
Sbjct: 407 ETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHV 466
Query: 697 -----FGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
G DQC +C L T CV CP+G Y D N C C +C+TC H
Sbjct: 467 KCFHCMGPAEDQCQTCPMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRH 524
Query: 752 N--CTECRDGLSLQGSRCSVSCEDGRYFNGQD--CQPCHRFCATCAGAGADGCINCTEGY 807
+ C CR G G C + C +G Y + C+ C+R C C G C++C +
Sbjct: 525 SRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFF 584
Query: 808 FM--EDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLG 865
F+ G C +SC YY + S++ +C++C +C C G G NC SC Y L G
Sbjct: 585 FLLRSKGECHRSCPDHYYVEQSTQ----TCERCHPTCDQCKGKGALNCLSCVWSYHLMGG 640
Query: 866 MC 867
+C
Sbjct: 641 IC 642
Score = 137 bits (345), Expect = 5e-32
Identities = 80/254 (31%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 633 AGPCDPECSEVGCDGPGPDHCNDC-LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAP 691
+G C+ C+E G D C C + + L + C S CP G Y A+ C +C+
Sbjct: 218 SGSCE-NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY-AEDGICERCSS 275
Query: 692 NCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
C +C G+ C SC+ G+ L+ C +CP+ K +C+ C E C+ C
Sbjct: 276 PCRTCEGN-ATNCHSCEGGHVLHHGV--CQENCPERHV--AVKGVCKHCPEMCQDCIHEK 330
Query: 752 NCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTE-GYFME 810
C EC L C SC G Y + + C PCH+ C C+G AD C C E + +
Sbjct: 331 TCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLY 390
Query: 811 DGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD-LGMCQM 869
DG C++ C Y++ + K C+ C SCLTC+ G CT+C G +++ G C
Sbjct: 391 DGLCLEECPAGTYYEKET----KECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMA 444
Query: 870 GAICKDATEESWAE 883
C + E W E
Sbjct: 445 NEKC--SPSEYWDE 456
Score = 114 bits (284), Expect = 5e-25
Identities = 90/300 (30%), Positives = 120/300 (40%), Gaps = 40/300 (13%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HA 681
P Y CD C CD G C C ++ L + CV C PG Y
Sbjct: 65 PEKTYSEAVECKACDSNCGS--CDQNG---CYWCEEGFFLLGGS---CVRKCGPGFYGDQ 116
Query: 682 DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHC----PDGSYQDTKKNLC 737
+ C C CE+C G D+C SC+ G L CV H +G + +
Sbjct: 117 EMGECESCHRACETCTGPGHDECSSCQEG--LQLLRGMCV-HATKTQEEGKFWNDILRKL 173
Query: 738 RKCSENCKTCTEFHN-CTECRDGLSLQGSRCSVSCEDGRY--FNGQDCQPCHRFCATCAG 794
+ C +CKTC CT C G L C SC G + C+ C CA C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC-- 231
Query: 795 AGADGCINCT----EGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGF 850
+GAD C C F+ +GRC C Y +E+G C++C C TC G
Sbjct: 232 SGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY----AEDGI--CERCSSPCRTCEG-NA 284
Query: 851 KNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCT 910
NC SC G++L G+CQ ++ E A G C + +CQ + + CK CT
Sbjct: 285 TNCHSCEGGHVLHHGVCQ-----ENCPERHVAVKGVCKHCPE--MCQ-DCIHEKTCKECT 336
Score = 103 bits (258), Expect = 6e-22
Identities = 62/211 (29%), Positives = 83/211 (39%), Gaps = 18/211 (8%)
Query: 623 PTDDYGTEDY--AGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYH 680
P Y ED C C C+G C+ C +++L C+ C G+Y
Sbjct: 498 PEGYYADEDSNRCAHCHSSCRT--CEGRHSRQCHSCRPGWFQLGKE---CLLQCREGYY- 551
Query: 681 ADKK--RCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCR 738
AD RC +C +C+ C G C+SC +FL C CPD Y + C
Sbjct: 552 ADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611
Query: 739 KCSENCKTC--TEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ----DCQPCHRFCATC 792
+C C C NC C L G C+ C G Y G+ +C+ CH C C
Sbjct: 612 RCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMEC 671
Query: 793 AGAGADGCINCTEG--YFMEDGRCVQSCSIS 821
G GA C C M+D C+ C+ S
Sbjct: 672 KGPGAKNCTLCPANLVLHMDDSHCLHCCNTS 702
Score = 95.9 bits (237), Expect = 2e-19
Identities = 63/208 (30%), Positives = 91/208 (43%), Gaps = 37/208 (17%)
Query: 714 NEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCED 773
N + C CP+ +Y + + C+ C NC +C + + C C +G L G C C
Sbjct: 54 NRFDHHCYKTCPEKTYSEAVE--CKACDSNCGSCDQ-NGCYWCEEGFFLLGGSCVRKCGP 110
Query: 774 GRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENG 831
G Y + + +C+ CHR C TC G G D C +C EG + G CV + + E G
Sbjct: 111 GFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATK-------TQEEG 163
Query: 832 ------YKSCKKCDISCLTCNGPGFKNCTSCPSG-YLLD---LGMCQMG-------AICK 874
+ + C SC TCNG CTSCP G YLL + C G C+
Sbjct: 164 KFWNDILRKLQPCHSSCKTCNGSA-TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 875 DATEESWAEGGFCMLVKKNNLCQRKVLQ 902
+ TE C + +LC++ +Q
Sbjct: 223 NCTEA-------CAICSGADLCKKCQMQ 243
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 156 bits (395), Expect = 7e-38
Identities = 88/248 (35%), Positives = 115/248 (46%), Gaps = 18/248 (7%)
Query: 626 DYGTEDYAG--PCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HAD 682
+Y ED G PC +C C GP D C C L N T CV CP G+Y D
Sbjct: 452 EYWDEDAPGCKPCHVKCFH--CMGPAEDQCQTC-PMNSLLLNTT--CVKDCPEGYYADED 506
Query: 683 KKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSE 742
RC C +C +C G H QC SC+ G+F + C+ C +G Y D C +C+
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNR 564
Query: 743 NCKTCTEFH--NCTECRDGLSLQGSR--CSVSCEDGRYF--NGQDCQPCHRFCATCAGAG 796
+CK C +C C L S+ C SC D Y + Q C+ CH C C G G
Sbjct: 565 SCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKG 624
Query: 797 ADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC 856
A C++C Y + G C C + Y E +C+KC SC+ C GPG KNCT C
Sbjct: 625 ALNCLSCVWSYHLMGGICTSDCLVGEY--RVGEGEKFNCEKCHESCMECKGPGAKNCTLC 682
Query: 857 PSGYLLDL 864
P+ +L +
Sbjct: 683 PANLVLHM 690
Score = 140 bits (354), Expect = 4e-33
Identities = 87/302 (28%), Positives = 119/302 (39%), Gaps = 67/302 (22%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPG-HYHA 681
P Y + PC +C E C GP D C CL + L + +C+ CP G +Y
Sbjct: 351 PRGFYADSRHCVPCHKDCLE--CSGPKADDCELCLESSWVLYDG--LCLEECPAGTYYEK 406
Query: 682 DKKRCRKC-------------------------------------------APNCESC-- 696
+ K CR C AP C+ C
Sbjct: 407 ETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHV 466
Query: 697 -----FGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
G DQC +C L T CV CP+G Y D N C C +C+TC H
Sbjct: 467 KCFHCMGPAEDQCQTCPMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRH 524
Query: 752 N--CTECRDGLSLQGSRCSVSCEDGRYFNGQD--CQPCHRFCATCAGAGADGCINCTEGY 807
+ C CR G G C + C +G Y + C+ C+R C C G C++C +
Sbjct: 525 SRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFF 584
Query: 808 FM--EDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLG 865
F+ G C +SC YY + S++ +C++C +C C G G NC SC Y L G
Sbjct: 585 FLLRSKGECHRSCPDHYYVEQSTQ----TCERCHPTCDQCKGKGALNCLSCVWSYHLMGG 640
Query: 866 MC 867
+C
Sbjct: 641 IC 642
Score = 137 bits (345), Expect = 5e-32
Identities = 80/254 (31%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 633 AGPCDPECSEVGCDGPGPDHCNDC-LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAP 691
+G C+ C+E G D C C + + L + C S CP G Y A+ C +C+
Sbjct: 218 SGSCE-NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY-AEDGICERCSS 275
Query: 692 NCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
C +C G+ C SC+ G+ L+ C +CP+ K +C+ C E C+ C
Sbjct: 276 PCRTCEGN-ATNCHSCEGGHVLHHGV--CQENCPERHV--AVKGVCKHCPEMCQDCIHEK 330
Query: 752 NCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTE-GYFME 810
C EC L C SC G Y + + C PCH+ C C+G AD C C E + +
Sbjct: 331 TCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLY 390
Query: 811 DGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD-LGMCQM 869
DG C++ C Y++ + K C+ C SCLTC+ G CT+C G +++ G C
Sbjct: 391 DGLCLEECPAGTYYEKET----KECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMA 444
Query: 870 GAICKDATEESWAE 883
C + E W E
Sbjct: 445 NEKC--SPSEYWDE 456
Score = 116 bits (290), Expect = 1e-25
Identities = 91/300 (30%), Positives = 121/300 (40%), Gaps = 40/300 (13%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HA 681
P Y E CD C CD G C C ++ L + CV C PG Y
Sbjct: 65 PEKTYSEEVECKACDSNCGS--CDQNG---CYWCEEGFFLLGGS---CVRKCGPGFYGDQ 116
Query: 682 DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHC----PDGSYQDTKKNLC 737
+ C C CE+C G D+C SC+ G L CV H +G + +
Sbjct: 117 EMGECESCHRACETCTGPGHDECSSCQEG--LQLLRGMCV-HATKTQEEGKFWNDILRKL 173
Query: 738 RKCSENCKTCTEFHN-CTECRDGLSLQGSRCSVSCEDGRY--FNGQDCQPCHRFCATCAG 794
+ C +CKTC CT C G L C SC G + C+ C CA C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC-- 231
Query: 795 AGADGCINCT----EGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGF 850
+GAD C C F+ +GRC C Y +E+G C++C C TC G
Sbjct: 232 SGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY----AEDGI--CERCSSPCRTCEG-NA 284
Query: 851 KNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCT 910
NC SC G++L G+CQ ++ E A G C + +CQ + + CK CT
Sbjct: 285 TNCHSCEGGHVLHHGVCQ-----ENCPERHVAVKGVCKHCPE--MCQ-DCIHEKTCKECT 336
Score = 103 bits (258), Expect = 6e-22
Identities = 62/211 (29%), Positives = 83/211 (39%), Gaps = 18/211 (8%)
Query: 623 PTDDYGTEDY--AGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYH 680
P Y ED C C C+G C+ C +++L C+ C G+Y
Sbjct: 498 PEGYYADEDSNRCAHCHSSCRT--CEGRHSRQCHSCRPGWFQLGKE---CLLQCREGYY- 551
Query: 681 ADKK--RCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCR 738
AD RC +C +C+ C G C+SC +FL C CPD Y + C
Sbjct: 552 ADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611
Query: 739 KCSENCKTC--TEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ----DCQPCHRFCATC 792
+C C C NC C L G C+ C G Y G+ +C+ CH C C
Sbjct: 612 RCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMEC 671
Query: 793 AGAGADGCINCTEG--YFMEDGRCVQSCSIS 821
G GA C C M+D C+ C+ S
Sbjct: 672 KGPGAKNCTLCPANLVLHMDDSHCLHCCNTS 702
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/208 (30%), Positives = 91/208 (43%), Gaps = 37/208 (17%)
Query: 714 NEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCED 773
N + C CP+ +Y + + C+ C NC +C + + C C +G L G C C
Sbjct: 54 NRFDHHCYKTCPEKTYSEEVE--CKACDSNCGSCDQ-NGCYWCEEGFFLLGGSCVRKCGP 110
Query: 774 GRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENG 831
G Y + + +C+ CHR C TC G G D C +C EG + G CV + + E G
Sbjct: 111 GFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATK-------TQEEG 163
Query: 832 ------YKSCKKCDISCLTCNGPGFKNCTSCPSG-YLLD---LGMCQMG-------AICK 874
+ + C SC TCNG CTSCP G YLL + C G C+
Sbjct: 164 KFWNDILRKLQPCHSSCKTCNGSA-TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 875 DATEESWAEGGFCMLVKKNNLCQRKVLQ 902
+ TE C + +LC++ +Q
Sbjct: 223 NCTEA-------CAICSGADLCKKCQMQ 243
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 139 bits (350), Expect = 1e-32
Identities = 86/244 (35%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 634 GPCDPECSEVGCD------GPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCR 687
G C P+C+ V C PDHC+ C L+N CV SC G Y A C
Sbjct: 410 GQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGW--CVHSCGLGFYQAGSL-CL 466
Query: 688 KCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTC 747
C P C +C + G +C SC+ + CV C DG YQD ++ C C E+C C
Sbjct: 467 ACQPQCSTC--TSGLECSSCQPPLLMRH--GQCVPTCGDGFYQD--RHSCAVCHESCAGC 520
Query: 748 ---TEFHNCTECRDGLS-LQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINC 803
TE H C CRD L L+ C SC G Y C C + C +C G + C+ C
Sbjct: 521 WGPTEKH-CLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSC-GPSSPRCLTC 578
Query: 804 TEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD 863
TE + DG+C+ C YY D + CK C SC +C+GP +CT+C L
Sbjct: 579 TEKTVLHDGKCMSECPGGYYADATGR-----CKVCHNSCASCSGPTPSHCTACSPPKALR 633
Query: 864 LGMC 867
G C
Sbjct: 634 QGHC 637
Score = 129 bits (325), Expect = 1e-29
Identities = 78/241 (32%), Positives = 108/241 (44%), Gaps = 19/241 (7%)
Query: 632 YAGPCDPECSEVGCDGPGPDH-CNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCA 690
Y C C D C C + +Y L + CV CP G+Y A++ C+KC
Sbjct: 805 YCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDH--CVPDCPSGYY-AERGACKKCH 861
Query: 691 PNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEF 750
+C +C G C SC L+ T +C T C G Y D ++C+ C+ +C +C
Sbjct: 862 SSCRTCQGRGPFSCSSCDTNLVLSH-TGTCSTTCFPGHYLDDN-HVCQPCNTHCGSCDSQ 919
Query: 751 HNCTECRDG--LSLQGSRCSVSCEDGRY--FNGQDCQPCHRFCATCAGAGADGCINCTEG 806
+CT CRD + L G SC Y F+ C+ C C+ C+G C+ C +G
Sbjct: 920 ASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDG 979
Query: 807 YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGM 866
Y ++DG CV+ C S+Y D KCD CL C GP CT C +LL
Sbjct: 980 YVLQDGACVEQCLSSFYQD-------SGLCKCDSYCLQCQGP--HECTRCKGPFLLLEAQ 1030
Query: 867 C 867
C
Sbjct: 1031 C 1031
Score = 104 bits (259), Expect = 4e-22
Identities = 81/282 (28%), Positives = 110/282 (39%), Gaps = 37/282 (13%)
Query: 603 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDP-EC--SEVGCDGPGPDHCNDCLHY 659
Y T EF R+ + G + GPC EC ++V C P C C
Sbjct: 351 YEETGEFMSSNASEVKRIPE-----GEKWEDGPCKVCECRGAQVTCYEPS---CPPCPVG 402
Query: 660 YYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNS 719
L+ + C C H H D C + +C+ C D + G+
Sbjct: 403 TLALEVKGQCC-PDCTSVHCHPDCLTCSQSPDHCDLC----QDPTKLLQNGW-------- 449
Query: 720 CVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNG 779
CV C G YQ +LC C C TCT C+ C+ L ++ +C +C DG Y +
Sbjct: 450 CVHSCGLGFYQ--AGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR 507
Query: 780 QDCQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKC 838
C CH CA C G C+ C + + + DG C SC +Y N +C C
Sbjct: 508 HSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFY------NRQGTCSAC 561
Query: 839 DISCLTCNGPGFKNCTSCPSGYLLDLGMCQM---GAICKDAT 877
D SC +C GP C +C +L G C G DAT
Sbjct: 562 DQSCDSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYYADAT 602
Score = 100 bits (248), Expect = 8e-21
Identities = 73/290 (25%), Positives = 103/290 (35%), Gaps = 65/290 (22%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
C C+ C GP P HC C + + C+ C G Y +D C+ C +C +
Sbjct: 608 CHNSCAS--CSGPTPSHCTACSPPKALRQGH---CLPRCGEGFY-SDHGVCKACHSSCLA 661
Query: 696 CFGSHGDQCMSCKY---GYFLNE------ETNSCVTHCPDGSYQDTKKNLCRKCSENCKT 746
C G C CK G + + + C+ C Y ++ +C C ++C
Sbjct: 662 CMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLEST-GICEACHQSCFR 720
Query: 747 CT--EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCT 804
C HNCT+C L +C C DG + C CH C C G CI+C
Sbjct: 721 CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCY 780
Query: 805 EGYFMEDGRCVQSCSISYYF---------------------------------------D 825
+ +G C SC + D
Sbjct: 781 PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD 840
Query: 826 H---SSENGY----KSCKKCDISCLTCNGPGFKNCTSCPSGYLLD-LGMC 867
H +GY +CKKC SC TC G G +C+SC + +L G C
Sbjct: 841 HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC 890
Score = 87.4 bits (215), Expect = 5e-17
Identities = 56/201 (27%), Positives = 81/201 (40%), Gaps = 22/201 (10%)
Query: 632 YAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCA 690
+ G CD + S C P K+ SC P +Y C++C
Sbjct: 912 HCGSCDSQASCTSCRDPN------------KVLLFGECQYESCAPQYYLDFSTNTCKECD 959
Query: 691 PNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEF 750
+C +C G C+ C GY L + +CV C YQD+ LC KC C C
Sbjct: 960 WSCSACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDS--GLC-KCDSYCLQCQGP 1014
Query: 751 HNCTECRDGLSLQGSRCSVSCEDGRYFN--GQDCQPCHRFCATCAGAGADGCINCTEGYF 808
H CT C+ L ++C C G + + C C + C C + D C C G+F
Sbjct: 1015 HECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHLCDHGFF 1072
Query: 809 MEDGRCVQSCSISYYFDHSSE 829
++ G CV +C + S+E
Sbjct: 1073 LKSGLCVYNCVPGFSVHTSNE 1093
Score = 52.4 bits (124), Expect = 2e-06
Identities = 75/333 (22%), Positives = 108/333 (32%), Gaps = 121/333 (36%)
Query: 634 GPCDPECSEVGCDGPG----------PDHCNDCLHYYYKLKNNTRICVS-SCPPGHYHAD 682
G C P+CS C G + C C+ +++ + + C+ C G A
Sbjct: 210 GKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRAR 269
Query: 683 K--KRCRKC---------------------APNCESCFGSHGD----------------- 702
+ + C +C CE C HG
Sbjct: 270 RHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDE 329
Query: 703 -----------QCMSCKYGYFLNEETN-------SCVTHCPDG-SYQDTKKNLCRKCSEN 743
+C+S + GY + EET S V P+G ++D +C +C
Sbjct: 330 ELIHLDGKCCPECIS-RNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVC-ECRGA 387
Query: 744 CKTCTEFHNCTECRDG---LSLQGSRC----SVSCED----------------------- 773
TC E +C C G L ++G C SV C
Sbjct: 388 QVTCYE-PSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQ 446
Query: 774 ----------GRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYY 823
G Y G C C C+TC +G + C +C M G+CV +C +Y
Sbjct: 447 NGWCVHSCGLGFYQAGSLCLACQPQCSTCT-SGLE-CSSCQPPLLMRHGQCVPTCGDGFY 504
Query: 824 FDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC 856
D SC C SC C GP K+C +C
Sbjct: 505 QDR------HSCAVCHESCAGCWGPTEKHCLAC 531
>gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Homo
sapiens]
Length = 353
Score = 81.3 bits (199), Expect = 4e-15
Identities = 65/220 (29%), Positives = 92/220 (41%), Gaps = 45/220 (20%)
Query: 698 GSHGDQCMSCKYGYFLNEETNSCVTHCP-DGSYQDTKKNLCRKCSENCKTCTEFHNCTEC 756
G++G C++C+ G ++ S HC DGS Q CR C + CT+C
Sbjct: 131 GTYGPDCLACQGG---SQRPCSGNGHCSGDGSRQGDGS--CR-----CHMGYQGPLCTDC 180
Query: 757 RDGL--SLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRC 814
DG SL+ S+ C C C TC+G C C G+ +++G C
Sbjct: 181 MDGYFSSLRNETHSI------------CTACDESCKTCSGLTNRDCGECEVGWVLDEGAC 228
Query: 815 VQ---------SCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLG 865
V CS + + ++ NG +C++CD SC+ C G G NC C SGY + G
Sbjct: 229 VDVDECAAEPPPCSAAQFCKNA--NGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHG 286
Query: 866 MCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLC 905
C D E S AE V+KN C +C
Sbjct: 287 Q------CADVDECSLAEK---TCVRKNENCYNTPGSYVC 317
Score = 52.0 bits (123), Expect = 3e-06
Identities = 43/189 (22%), Positives = 67/189 (35%), Gaps = 43/189 (22%)
Query: 643 VGCDGPGPDHCNDCLH-YYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHG 701
+G GP C DC+ Y+ L+N T C C +C++C G
Sbjct: 170 MGYQGP---LCTDCMDGYFSSLRNETHSI---------------CTACDESCKTCSGLTN 211
Query: 702 DQCMSCKYGYFLNE----ETNSCVTHCPDGSYQDTKKN-----LCRKCSENCKTCTEF-- 750
C C+ G+ L+E + + C P S KN C +C +C CT
Sbjct: 212 RDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGP 271
Query: 751 HNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCA----TCAGAGADGCINCTEG 806
NC EC G + + +C+ + +C + C C C +G
Sbjct: 272 GNCKECISGYAREHGQCA---------DVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
Query: 807 YFMEDGRCV 815
+ + CV
Sbjct: 323 FEETEDACV 331
Score = 37.4 bits (85), Expect = 0.064
Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 13/86 (15%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
CD C VGC G GP +C +C+ Y + ++ V C + C E+
Sbjct: 259 CDSSC--VGCTGEGPGNCKECISGYAR-EHGQCADVDECSLAE--------KTCVRKNEN 307
Query: 696 CFGSHGDQCMSCKYGYFLNEETNSCV 721
C+ + G C G+ E ++CV
Sbjct: 308 CYNTPGSYVCVCPDGF--EETEDACV 331
>gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Homo
sapiens]
Length = 402
Score = 76.3 bits (186), Expect = 1e-13
Identities = 73/269 (27%), Positives = 97/269 (36%), Gaps = 67/269 (24%)
Query: 674 CPPGHYHADKKRC-----RKCAPN--CESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPD 726
C PG Y D C R C+ N C GD C GY T C D
Sbjct: 128 CSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGY-----QGPLCTDCMD 182
Query: 727 GSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRC--SVSCEDG---RYFNGQD 781
G + + E H+ R GLS C S+ C G + G++
Sbjct: 183 GYFSSLRN--------------ETHSICTVRTGLSDSYPPCCLSLGCWRGVGHAWIRGRN 228
Query: 782 C--QP--------------CHRFCATCAGAGADGCINCTEGYFMEDGRCVQ--------- 816
QP C C TC+G C C G+ +++G CV
Sbjct: 229 THTQPGYSSRVWIAAFSPACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPP 288
Query: 817 SCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDA 876
CS + + ++ NG +C++CD SC+ C G G NC C SGY + G C D
Sbjct: 289 PCSAAQFCKNA--NGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQ------CADV 340
Query: 877 TEESWAEGGFCMLVKKNNLCQRKVLQQLC 905
E S AE V+KN C +C
Sbjct: 341 DECSLAEK---TCVRKNENCYNTPGSYVC 366
Score = 37.4 bits (85), Expect = 0.064
Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 13/86 (15%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
CD C VGC G GP +C +C+ Y + ++ V C + C E+
Sbjct: 308 CDSSC--VGCTGEGPGNCKECISGYAR-EHGQCADVDECSLAE--------KTCVRKNEN 356
Query: 696 CFGSHGDQCMSCKYGYFLNEETNSCV 721
C+ + G C G+ E ++CV
Sbjct: 357 CYNTPGSYVCVCPDGF--EETEDACV 380
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 70.5 bits (171), Expect = 7e-12
Identities = 80/269 (29%), Positives = 102/269 (37%), Gaps = 48/269 (17%)
Query: 640 CSEVGCDGPGPDHCNDCLHYYYKLKNNTRI-CVSSCPPGHYHADKKRCRKCAPNCE-SCF 697
CSE CD D C+ + L T I C S+CPPG + PNC SC
Sbjct: 532 CSE-HCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRW----------GPNCSVSCS 580
Query: 698 GSHGDQCM------SCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFH 751
+G C C G+ C CP G Y C C + + C
Sbjct: 581 CENGGSCSPEDGSCECAPGF----RGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHIS 636
Query: 752 NCTECRDGLSLQGSRCSVSCEDGRYFNGQDC-QPCHRFCATCAGAGA----DGCINCTEG 806
EC G S G+ C+ C G YF GQDC Q C +CA G DG C G
Sbjct: 637 GICECLPGFS--GALCNQVCAGG-YF-GQDCAQLC-----SCANNGTCSPIDGSCQCFPG 687
Query: 807 YFMEDGRCVQSCSISYY----FDHSSENGYKSCKKCDISCLTCNGPGFKNCTS-CPSGYL 861
+ +D C Q+C ++ F S + SC D +C G CT CP+ +
Sbjct: 688 WIGKD--CSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFF 745
Query: 862 -LDLG---MCQMGAICKDATEESWAEGGF 886
D G CQ GA C + + GF
Sbjct: 746 GKDCGRVCQCQNGASCDHISGKCTCRTGF 774
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/239 (25%), Positives = 82/239 (34%), Gaps = 60/239 (25%)
Query: 669 ICVSSCPPGHYHADKK---------RCRKCAPNCESCFGSHGDQCM-SCKYGYFLNEETN 718
+C CPPG + + +C C G GD+C C +G F + +
Sbjct: 257 VCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQ 316
Query: 719 SCVTH---------------------------CPDGSYQDTKKNLCRKCSENCKTCTEFH 751
C H CP+G + C ++N +C
Sbjct: 317 HCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVT 376
Query: 752 NCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQ-PCHRFCATCAGAGAD-----GCINCTE 805
C+ G S G C+ SC G Y G CQ PC TC GAD G C
Sbjct: 377 GACTCQPGWS--GHHCNESCPVGYY--GDGCQLPC-----TCQN-GADCHSITGGCTCAP 426
Query: 806 GYFMEDGRCVQSCSISYYFDHSSE----NGYKSCKKCDISCLTCNGPGFKNCT-SCPSG 859
G+ E C SC+ Y + S N +C D SC G +CT CPSG
Sbjct: 427 GFMGE--VCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSG 483
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/129 (33%), Positives = 55/129 (42%), Gaps = 31/129 (24%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSC-----PPGHYHADKKRCRKCA 690
CDP CS GC GPGP C C +Y + +CV+ C P + A + C C
Sbjct: 500 CDPLCSSGGCWGPGPGQCLSCRNY-----SRGGVCVTHCNFLNGEPREF-AHEAECFSCH 553
Query: 691 PNCE------SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDG---------SYQDTKKN 735
P C+ +C GS D C C + + CV+ CP G Y D +N
Sbjct: 554 PECQPMEGTATCNGSGSDTCAQCAH----FRDGPHCVSSCPHGVLGAKGPIYKYPDV-QN 608
Query: 736 LCRKCSENC 744
CR C ENC
Sbjct: 609 ECRPCHENC 617
Score = 47.4 bits (111), Expect = 6e-05
Identities = 48/177 (27%), Positives = 66/177 (37%), Gaps = 59/177 (33%)
Query: 689 CAPNCES--CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKT 746
C P C S C+G QC+SC+ CVTHC ++ + +
Sbjct: 500 CDPLCSSGGCWGPGPGQCLSCRN----YSRGGVCVTHC---NFLNGEPR----------- 541
Query: 747 CTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEG 806
EF + EC SC +CQP ATC G+G+D C C
Sbjct: 542 --EFAHEAEC------------FSCHP-------ECQPMEG-TATCNGSGSDTCAQC--A 577
Query: 807 YFMEDGRCVQSC---------SISYYFDHSSENGYKSCKKCDISCLT-CNGPGFKNC 853
+F + CV SC I Y D +E C+ C +C C GP ++C
Sbjct: 578 HFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNE-----CRPCHENCTQGCKGPELQDC 629
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/115 (28%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
C EC+ GC GP C C H+ N++ CV CP + K + PN +
Sbjct: 227 CHDECAG-GCSGPQDTDCFACRHF-----NDSGACVPRCPQPLVY--NKLTFQLEPNPHT 278
Query: 696 CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNL--CRKCSENC-KTC 747
+ G SC + + +++ SCV CP + K L C C C K C
Sbjct: 279 KYQYGGVCVASCPHNFVVDQ--TSCVRACPPDKMEVDKNGLKMCEPCGGLCPKAC 331
Score = 36.2 bits (82), Expect = 0.14
Identities = 23/91 (25%), Positives = 37/91 (40%), Gaps = 15/91 (16%)
Query: 778 NGQDCQPCHRFC-ATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK 836
NG+ C PCH C C G G++ C T+ C C+ + + ++ + C
Sbjct: 179 NGRSCPPCHEVCKGRCWGPGSEDCQTLTKTI------CAPQCNGHCFGPNPNQCCHDECA 232
Query: 837 KCDISCLTCNGPGFKNCTSCPSGYLLDLGMC 867
C+GP +C +C + D G C
Sbjct: 233 G------GCSGPQDTDCFAC--RHFNDSGAC 255
Score = 35.0 bits (79), Expect = 0.32
Identities = 24/84 (28%), Positives = 31/84 (36%), Gaps = 19/84 (22%)
Query: 785 CHRFCAT--CAGAGADGCINCTEGYFMEDGRCVQSCSI----SYYFDHSSENGYKSCKKC 838
C C++ C G G C++C + G CV C+ F H +E C C
Sbjct: 500 CDPLCSSGGCWGPGPGQCLSCRN--YSRGGVCVTHCNFLNGEPREFAHEAE-----CFSC 552
Query: 839 DISC------LTCNGPGFKNCTSC 856
C TCNG G C C
Sbjct: 553 HPECQPMEGTATCNGSGSDTCAQC 576
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 62.0 bits (149), Expect = 2e-09
Identities = 40/129 (31%), Positives = 53/129 (41%), Gaps = 30/129 (23%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP--PGHYH--ADKKRCRKCAP 691
C+ CS GC GPGPD C C + + RIC+ SC G + + C +C P
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRRF-----SRGRICIESCNLYDGEFREFENGSICVECDP 557
Query: 692 NCE-------SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDG---------SYQDTKKN 735
CE +C G D C C + ++ +CV CPDG Y D +
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKCSH----FKDGPNCVEKCPDGLQGANSFIFKYADPDRE 613
Query: 736 LCRKCSENC 744
C C NC
Sbjct: 614 -CHPCHPNC 621
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 12/81 (14%)
Query: 785 CHRFCAT--CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISC 842
C+ C++ C G G D C++C F C++SC++ ENG C +CD C
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRR--FSRGRICIESCNLYDGEFREFENG-SICVECDPQC 559
Query: 843 -------LTCNGPGFKNCTSC 856
LTC+GPG NCT C
Sbjct: 560 EKMEDGLLTCHGPGPDNCTKC 580
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/174 (22%), Positives = 65/174 (37%), Gaps = 56/174 (32%)
Query: 694 ESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP--DGSYQDTKK-NLCRKCSENCKTCTEF 750
+ C+G DQC+SC+ C+ C DG +++ + ++C +C C+
Sbjct: 510 DGCWGPGPDQCLSCRRF----SRGRICIESCNLYDGEFREFENGSICVECDPQCE----- 560
Query: 751 HNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFME 810
+ DGL TC G G D C C+ +F +
Sbjct: 561 ----KMEDGL-----------------------------LTCHGPGPDNCTKCS--HFKD 585
Query: 811 DGRCVQSC------SISYYFDHSSENGYKSCKKCDISCLT-CNGPGFKNCTSCP 857
CV+ C + S+ F ++ + + C C +C CNGP +C P
Sbjct: 586 GPNCVEKCPDGLQGANSFIFKYADPD--RECHPCHPNCTQGCNGPTSHDCIYYP 637
Score = 44.7 bits (104), Expect = 4e-04
Identities = 42/168 (25%), Positives = 61/168 (36%), Gaps = 19/168 (11%)
Query: 686 CRKCAPNCES-CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLC-RKCSEN 743
C +C +C C+G + C + C C Y + C R+C+
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLT--------RTVCAEQCDGRCYGPYVSDCCHRECAGG 237
Query: 744 CKTCTEFHNCTECRDGLSLQGS-RCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCIN 802
C + T+C ++ S C C +N Q H F A GA
Sbjct: 238 CSGPKD----TDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYT-YGAFCVKK 292
Query: 803 CTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKC-DISCLTCNGPG 849
C + ++ CV++C S ENG K CK C DI C+G G
Sbjct: 293 CPHNFVVDSSSCVRACPSSKM--EVEENGIKMCKPCTDICPKACDGIG 338
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 20/139 (14%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
C EC+ GC GP C C+++ N++ CV+ CP + + N +
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNF-----NDSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283
Query: 696 CFGSHGDQCM-SCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCT 754
+G+ C+ C + + + +++SCV CP + + + + CK CT+ C
Sbjct: 284 TYGAF---CVKKCPHNFVV--DSSSCVRACPSSKMEVEENGI-----KMCKPCTDI--CP 331
Query: 755 ECRDGLSLQGSRCSVSCED 773
+ DG+ GS S D
Sbjct: 332 KACDGIG-TGSLMSAQTVD 349
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 62.0 bits (149), Expect = 2e-09
Identities = 40/129 (31%), Positives = 53/129 (41%), Gaps = 30/129 (23%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP--PGHYH--ADKKRCRKCAP 691
C+ CS GC GPGPD C C + + RIC+ SC G + + C +C P
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRRF-----SRGRICIESCNLYDGEFREFENGSICVECDP 557
Query: 692 NCE-------SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDG---------SYQDTKKN 735
CE +C G D C C + ++ +CV CPDG Y D +
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKCSH----FKDGPNCVEKCPDGLQGANSFIFKYADPDRE 613
Query: 736 LCRKCSENC 744
C C NC
Sbjct: 614 -CHPCHPNC 621
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 12/81 (14%)
Query: 785 CHRFCAT--CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISC 842
C+ C++ C G G D C++C F C++SC++ ENG C +CD C
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRR--FSRGRICIESCNLYDGEFREFENG-SICVECDPQC 559
Query: 843 -------LTCNGPGFKNCTSC 856
LTC+GPG NCT C
Sbjct: 560 EKMEDGLLTCHGPGPDNCTKC 580
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/174 (22%), Positives = 65/174 (37%), Gaps = 56/174 (32%)
Query: 694 ESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP--DGSYQDTKK-NLCRKCSENCKTCTEF 750
+ C+G DQC+SC+ C+ C DG +++ + ++C +C C+
Sbjct: 510 DGCWGPGPDQCLSCRRF----SRGRICIESCNLYDGEFREFENGSICVECDPQCE----- 560
Query: 751 HNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFME 810
+ DGL TC G G D C C+ +F +
Sbjct: 561 ----KMEDGL-----------------------------LTCHGPGPDNCTKCS--HFKD 585
Query: 811 DGRCVQSC------SISYYFDHSSENGYKSCKKCDISCLT-CNGPGFKNCTSCP 857
CV+ C + S+ F ++ + + C C +C CNGP +C P
Sbjct: 586 GPNCVEKCPDGLQGANSFIFKYADPD--RECHPCHPNCTQGCNGPTSHDCIYYP 637
Score = 44.7 bits (104), Expect = 4e-04
Identities = 42/168 (25%), Positives = 61/168 (36%), Gaps = 19/168 (11%)
Query: 686 CRKCAPNCES-CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLC-RKCSEN 743
C +C +C C+G + C + C C Y + C R+C+
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLT--------RTVCAEQCDGRCYGPYVSDCCHRECAGG 237
Query: 744 CKTCTEFHNCTECRDGLSLQGS-RCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCIN 802
C + T+C ++ S C C +N Q H F A GA
Sbjct: 238 CSGPKD----TDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYT-YGAFCVKK 292
Query: 803 CTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKC-DISCLTCNGPG 849
C + ++ CV++C S ENG K CK C DI C+G G
Sbjct: 293 CPHNFVVDSSSCVRACPSSKM--EVEENGIKMCKPCTDICPKACDGIG 338
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 20/139 (14%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
C EC+ GC GP C C+++ N++ CV+ CP + + N +
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNF-----NDSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283
Query: 696 CFGSHGDQCM-SCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCT 754
+G+ C+ C + + + +++SCV CP + + + + CK CT+ C
Sbjct: 284 TYGAF---CVKKCPHNFVV--DSSSCVRACPSSKMEVEENGI-----KMCKPCTDI--CP 331
Query: 755 ECRDGLSLQGSRCSVSCED 773
+ DG+ GS S D
Sbjct: 332 KACDGIG-TGSLMSAQTVD 349
>gi|84490388 R-spondin1 [Homo sapiens]
Length = 263
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/95 (33%), Positives = 47/95 (49%), Gaps = 11/95 (11%)
Query: 689 CAPNCESCFGSHGDQCMSCKYGYFLNEETNS------CVTHCPDGSY--QDTKKNLCRKC 740
CA CE C +G C+ C F+ E N C+ CP G + ++ N C KC
Sbjct: 40 CAKGCELCSEVNG--CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
Query: 741 S-ENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG 774
E+C+ C + CT+C++GL L RC +C +G
Sbjct: 98 KIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG 132
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/113 (36%), Positives = 58/113 (51%), Gaps = 27/113 (23%)
Query: 628 GTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKL-----KNNTR---ICVSSCPPGHY 679
G++ A C+ CSEV N CL KL +N+ R +C+ SCPPG++
Sbjct: 36 GSQACAKGCEL-CSEV----------NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYF 84
Query: 680 HA---DKKRCRKC-APNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGS 728
A D +C KC +CE+CF SH + C CK G +L++ C CP+GS
Sbjct: 85 DARNPDMNKCIKCKIEHCEACF-SH-NFCTKCKEGLYLHK--GRCYPACPEGS 133
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/134 (26%), Positives = 54/134 (40%), Gaps = 24/134 (17%)
Query: 740 CSENCKTCTEFHNCTECRDGLSLQGSR--------CSVSCEDGRYFNGQD-----CQPCH 786
C++ C+ C+E + C +C L + R C SC G YF+ ++ C C
Sbjct: 40 CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPG-YFDARNPDMNKCIKCK 98
Query: 787 -RFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK---KCDISC 842
C C C C EG ++ GRC +C S+ NG C +C++S
Sbjct: 99 IEHCEACFSHNF--CTKCKEGLYLHKGRCYPACPEG----SSAANGTMECSSPAQCEMSE 152
Query: 843 LTCNGPGFKNCTSC 856
+ GP K C
Sbjct: 153 WSPWGPCSKKQQLC 166
Score = 42.7 bits (99), Expect = 0.002
Identities = 38/145 (26%), Positives = 54/145 (37%), Gaps = 31/145 (21%)
Query: 775 RYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFM--------EDGRCVQSCSISYYFDH 826
R + + Q C + C C+ +GC+ C+ F+ + G C+ SC Y+
Sbjct: 30 RRISAEGSQACAKGCELCSEV--NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDAR 87
Query: 827 SSENGYKSCKKCDIS-CLTCNGPGFKNCTSCPSGYLLDLG----MCQMGAICKDATEE-- 879
+ + C KC I C C F CT C G L G C G+ + T E
Sbjct: 88 NPD--MNKCIKCKIEHCEACFSHNF--CTKCKEGLYLHKGRCYPACPEGSSAANGTMECS 143
Query: 880 --------SWAEGGFCMLVKKNNLC 896
W+ G C KK LC
Sbjct: 144 SPAQCEMSEWSPWGPCS--KKQQLC 166
>gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]
Length = 639
Score = 59.3 bits (142), Expect = 2e-08
Identities = 50/187 (26%), Positives = 74/187 (39%), Gaps = 33/187 (17%)
Query: 685 RCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENC 744
RC + CE G G C +CK G++LN + C C CS +
Sbjct: 253 RCNQTTGQCECRPGYQGLHCETCKEGFYLNYTSGLC-QPC--------------DCSPHG 297
Query: 745 KTCTEFHNCTECRDGLSLQGSRCSVSCEDGRY-FNGQDCQP--CHRFCATCAGAGADGCI 801
++ +C+ + + GS C C+DG Y F+ C P C+ A+C A C+
Sbjct: 298 ALSIPCNSSGKCQCKVGVIGSICD-RCQDGYYGFSKNGCLPCQCNNRSASC-DALTGACL 355
Query: 802 NCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGP-GFKN------CT 854
NC E G + C +Y S + K C +C S +T G K+ C
Sbjct: 356 NCQEN---SKGNHCEECKEGFY---QSPDATKECLRCPCSAVTSTGSCSIKSSELEPECD 409
Query: 855 SCPSGYL 861
C GY+
Sbjct: 410 QCKDGYI 416
Score = 38.5 bits (88), Expect = 0.029
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 17/120 (14%)
Query: 651 DHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKK---RCRKCAPNCESC-FGSHGDQCMS 706
+HC +C +Y+ + T+ C+ CP + + + P C+ C G G C
Sbjct: 364 NHCEECKEGFYQSPDATKECL-RCPCSAVTSTGSCSIKSSELEPECDQCKDGYIGPNCNK 422
Query: 707 CKYGYFLNEETNSCVTHCPDGSYQDTKK--NLCRKCSENCKTCTEFHN-----CTECRDG 759
C+ GY+ +S C + D K +C+ S C C HN C C +G
Sbjct: 423 CENGYY---NFDSICRKCQCHGHVDPVKTPKICKPESGECINC--LHNTTGFWCENCLEG 477
Score = 35.4 bits (80), Expect = 0.24
Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 15/101 (14%)
Query: 637 DPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRK-CAPNCES 695
+PEC + GP+ CN C + YY + R C C H H D + K C P
Sbjct: 405 EPECDQCKDGYIGPN-CNKCENGYYNFDSICRKC--QC---HGHVDPVKTPKICKPESGE 458
Query: 696 CF----GSHGDQCMSCKYGYFLNEETN----SCVTHCPDGS 728
C + G C +C GY + E N + P+GS
Sbjct: 459 CINCLHNTTGFWCENCLEGYVHDLEGNCIKKEVILPTPEGS 499
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 58.5 bits (140), Expect = 3e-08
Identities = 42/157 (26%), Positives = 61/157 (38%), Gaps = 38/157 (24%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP-----PG 677
P D+ E A C C+ C GPGP C +C + + CV C P
Sbjct: 470 PEDECVGEGLA--CHQLCARGHCWGPGPTQCVNCSQFL-----RGQECVEECRVLQGLPR 522
Query: 678 HYHADKKRCRKCAPNCE------SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQD 731
Y + + C C P C+ +CFG DQC++C + ++ CV CP G D
Sbjct: 523 EY-VNARHCLPCHPECQPQNGSVTCFGPEADQCVACAH----YKDPPFCVARCPSGVKPD 577
Query: 732 ----------TKKNLCRKCSENCKTCTEFHNCTECRD 758
++ C+ C NC H+C + D
Sbjct: 578 LSYMPIWKFPDEEGACQPCPINCT-----HSCVDLDD 609
Score = 48.1 bits (113), Expect = 4e-05
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 16/114 (14%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPP-GHYHADKKRCRKCAPNCE 694
C +C+ GC GP C CLH+ N++ IC CP Y+ D + PN E
Sbjct: 206 CHEQCA-AGCTGPKHSDCLACLHF-----NHSGICELHCPALVTYNTDTF---ESMPNPE 256
Query: 695 SCFGSHGDQCMS-CKYGYFLNEETNSCVTHCPDGSYQDTKKN---LCRKCSENC 744
+ + G C++ C Y Y L+ + SC CP + + T ++ C KCS+ C
Sbjct: 257 GRY-TFGASCVTACPYNY-LSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPC 308
Score = 44.7 bits (104), Expect = 4e-04
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 11/80 (13%)
Query: 785 CHRFCAT--CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISC 842
CH+ CA C G G C+NC++ F+ CV+ C + N + C C C
Sbjct: 481 CHQLCARGHCWGPGPTQCVNCSQ--FLRGQECVEECRVLQGLPREYVNA-RHCLPCHPEC 537
Query: 843 ------LTCNGPGFKNCTSC 856
+TC GP C +C
Sbjct: 538 QPQNGSVTCFGPEADQCVAC 557
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 30/116 (25%)
Query: 744 CKTCTEFHNCTECRDGLSLQGSRCSVSCE-----DGRYFNGQDCQPCHRFC------ATC 792
C C++F L+G C C Y N + C PCH C TC
Sbjct: 498 CVNCSQF-----------LRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTC 546
Query: 793 AGAGADGCINCTEGYFMEDGRCVQSC------SISYYFDHSSENGYKSCKKCDISC 842
G AD C+ C ++ + CV C +SY + +C+ C I+C
Sbjct: 547 FGPEADQCVAC--AHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 600
Score = 32.7 bits (73), Expect = 1.6
Identities = 39/180 (21%), Positives = 65/180 (36%), Gaps = 31/180 (17%)
Query: 684 KRCRKCAPNCES--CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCS 741
+ C C+P C+ C+G + C S T C G + C
Sbjct: 160 RACHPCSPMCKGSRCWGESSEDCQSLTR------------TVCAGGCARCKGPLPTDCCH 207
Query: 742 ENCKT-CT--EFHNCTEC----RDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAG 794
E C CT + +C C G+ V+ + + + + + F A+C
Sbjct: 208 EQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVT 267
Query: 795 AGADGCINCTEGYFMED-GRCVQSCSISYYFDHSSENGYKSCKKCDISCL-TCNGPGFKN 852
A C Y D G C C + + + ++E+G + C+KC C C G G ++
Sbjct: 268 A-------CPYNYLSTDVGSCTLVCPL-HNQEVTAEDGTQRCEKCSKPCARVCYGLGMEH 319
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 58.5 bits (140), Expect = 3e-08
Identities = 42/157 (26%), Positives = 61/157 (38%), Gaps = 38/157 (24%)
Query: 623 PTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP-----PG 677
P D+ E A C C+ C GPGP C +C + + CV C P
Sbjct: 500 PEDECVGEGLA--CHQLCARGHCWGPGPTQCVNCSQFL-----RGQECVEECRVLQGLPR 552
Query: 678 HYHADKKRCRKCAPNCE------SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQD 731
Y + + C C P C+ +CFG DQC++C + ++ CV CP G D
Sbjct: 553 EY-VNARHCLPCHPECQPQNGSVTCFGPEADQCVACAH----YKDPPFCVARCPSGVKPD 607
Query: 732 ----------TKKNLCRKCSENCKTCTEFHNCTECRD 758
++ C+ C NC H+C + D
Sbjct: 608 LSYMPIWKFPDEEGACQPCPINCT-----HSCVDLDD 639
Score = 48.1 bits (113), Expect = 4e-05
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 16/114 (14%)
Query: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPP-GHYHADKKRCRKCAPNCE 694
C +C+ GC GP C CLH+ N++ IC CP Y+ D + PN E
Sbjct: 236 CHEQCA-AGCTGPKHSDCLACLHF-----NHSGICELHCPALVTYNTDTF---ESMPNPE 286
Query: 695 SCFGSHGDQCMS-CKYGYFLNEETNSCVTHCPDGSYQDTKKN---LCRKCSENC 744
+ + G C++ C Y Y L+ + SC CP + + T ++ C KCS+ C
Sbjct: 287 GRY-TFGASCVTACPYNY-LSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPC 338
Score = 44.7 bits (104), Expect = 4e-04
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 11/80 (13%)
Query: 785 CHRFCAT--CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISC 842
CH+ CA C G G C+NC++ F+ CV+ C + N + C C C
Sbjct: 511 CHQLCARGHCWGPGPTQCVNCSQ--FLRGQECVEECRVLQGLPREYVNA-RHCLPCHPEC 567
Query: 843 ------LTCNGPGFKNCTSC 856
+TC GP C +C
Sbjct: 568 QPQNGSVTCFGPEADQCVAC 587
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 30/116 (25%)
Query: 744 CKTCTEFHNCTECRDGLSLQGSRCSVSCE-----DGRYFNGQDCQPCHRFC------ATC 792
C C++F L+G C C Y N + C PCH C TC
Sbjct: 528 CVNCSQF-----------LRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTC 576
Query: 793 AGAGADGCINCTEGYFMEDGRCVQSC------SISYYFDHSSENGYKSCKKCDISC 842
G AD C+ C ++ + CV C +SY + +C+ C I+C
Sbjct: 577 FGPEADQCVAC--AHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 630
Score = 32.7 bits (73), Expect = 1.6
Identities = 39/180 (21%), Positives = 65/180 (36%), Gaps = 31/180 (17%)
Query: 684 KRCRKCAPNCES--CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCS 741
+ C C+P C+ C+G + C S T C G + C
Sbjct: 190 RACHPCSPMCKGSRCWGESSEDCQSLTR------------TVCAGGCARCKGPLPTDCCH 237
Query: 742 ENCKT-CT--EFHNCTEC----RDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAG 794
E C CT + +C C G+ V+ + + + + + F A+C
Sbjct: 238 EQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVT 297
Query: 795 AGADGCINCTEGYFMED-GRCVQSCSISYYFDHSSENGYKSCKKCDISCL-TCNGPGFKN 852
A C Y D G C C + + + ++E+G + C+KC C C G G ++
Sbjct: 298 A-------CPYNYLSTDVGSCTLVCPL-HNQEVTAEDGTQRCEKCSKPCARVCYGLGMEH 349
>gi|143770880 laminin, beta 4 [Homo sapiens]
Length = 1761
Score = 57.4 bits (137), Expect = 6e-08
Identities = 62/260 (23%), Positives = 87/260 (33%), Gaps = 35/260 (13%)
Query: 632 YAGPCDPECSEV-GCDG-PGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKC 689
+A CDPE C G +C C+ YY ++ + C P +++ C
Sbjct: 868 FAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSC 927
Query: 690 APN-------CESCFGSHGDQCMSCKYGYFLNEETNS--CVTHCPDGSYQDTKKNLCRKC 740
N C G G QC C G++ N + C + + T C +
Sbjct: 928 YQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRV 987
Query: 741 SENCKTC---TEFHNCTECRDG-----LSLQGSRCS--------VSCEDGRYFNGQDCQP 784
+ C C T+ NC C+ G L+ RCS + C G C P
Sbjct: 988 TGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGG--GACLCDP 1045
Query: 785 CHRFCATCAGAGADGCINCTEGYF-MEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCL 843
C C C +GY+ + GR QSC SS C + C
Sbjct: 1046 VTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSH-----CDQLTGQCP 1100
Query: 844 TCNGPGFKNCTSCPSGYLLD 863
G G K C+ C Y D
Sbjct: 1101 CKLGYGGKRCSECQENYYGD 1120
Score = 49.7 bits (117), Expect = 1e-05
Identities = 61/246 (24%), Positives = 81/246 (32%), Gaps = 50/246 (20%)
Query: 621 EDPTDDYGTEDYAG-PCDPECSEVGCDGPGPDHCN----DCLHYYYKLKNNTRICVSSCP 675
E T YG +G PC P D P+ C+ +CL L N C
Sbjct: 951 ECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRC---LHNTQGANCQLCK 1007
Query: 676 PGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYG---YFLNEETNSC----------V 721
PGHY A + CR+C SC S G M C G + T +C
Sbjct: 1008 PGHYGSALNQTCRRC-----SCHAS-GVSPMECPPGGGACLCDPVTGACPCLPNVTGLAC 1061
Query: 722 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTE----CRDGLSLQGSRCSVSCEDGRYF 777
C DG + C+ C + +T H C + C L G RCS C++ Y
Sbjct: 1062 DRCADGYWNLVPGRGCQSCDCDPRTSQSSH-CDQLTGQCPCKLGYGGKRCS-ECQENYYG 1119
Query: 778 NGQD----------------CQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSIS 821
+ C P C G C C G+ E C+Q
Sbjct: 1120 DPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCF 1179
Query: 822 YYFDHS 827
+DH+
Sbjct: 1180 DQWDHT 1185
Score = 33.1 bits (74), Expect = 1.2
Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 61/241 (25%)
Query: 675 PPGHYHADKK-RCRKCAPNCESCFGSHGDQ------------CMSCKYGYFLNEETNSC- 720
PPG H + PNCE C D C SC N ++ C
Sbjct: 287 PPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCS----CNSHSSRCH 342
Query: 721 ---VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTEC-----RDGL-SLQGSRCSVSC 771
T+ G +C C N TE +C C RD L ++ + C
Sbjct: 343 FDMTTYLASGGLSG---GVCEDCQHN----TEGQHCDRCRPLFYRDPLKTISDPYACIPC 395
Query: 772 E---DGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSS 828
E DG G C G+ A C+ C E +E +C Q C ++Y S
Sbjct: 396 ECDPDGTISGG----ICVSHSDPALGSVAGQCL-CKEN--VEGAKCDQ-CKPNHY--GLS 445
Query: 829 ENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMC-----QMGAICKDATEESWAE 883
C+ CD CN G +C +D G C GA C++ T W
Sbjct: 446 ATDPLGCQPCD-----CNPLGSLPFLTCD----VDTGQCLCLSYVTGAHCEECTVGYWGL 496
Query: 884 G 884
G
Sbjct: 497 G 497
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 56.2 bits (134), Expect = 1e-07
Identities = 50/174 (28%), Positives = 68/174 (39%), Gaps = 35/174 (20%)
Query: 661 YKLKNNTRICVSSCPPGHY-HADKKRCRK---CA---PNCE-SCFGSHGDQCMSCKYGYF 712
Y N R CP GH +D K C K CA CE SC S C GY
Sbjct: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556
Query: 713 LNEETNSCVTHCPDGSYQDTKKNLCRK----CSENCKTCTEFHNCTECRDGLSLQGSRCS 768
L E+ +C +K++C+ C C + + C EC +G L
Sbjct: 557 LREDGKTC-----------RRKDVCQAIDHGCEHICVNSDDSYTC-ECLEGFRL------ 598
Query: 769 VSCEDGRYFNGQD-CQPCHRFCA-TCAGAGADGCINCTEGYFM-EDGRCVQSCS 819
EDG+ +D C+ H C C G C+EG+ + EDGR + C+
Sbjct: 599 --AEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
Score = 32.7 bits (73), Expect = 1.6
Identities = 42/177 (23%), Positives = 56/177 (31%), Gaps = 27/177 (15%)
Query: 686 CRKCAPNCES-CFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENC 744
C NC C G CK GY LN + +C QD C + C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC-------RIQDLCAMEDHNCEQLC 294
Query: 745 KTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD-CQPCHRFCA-TCAGAGADGCIN 802
C +C G +L EDG+ D C + C C A
Sbjct: 295 VNVPGSFVC-QCYSGYAL--------AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ 345
Query: 803 CTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCD--ISCLTCNG----PGFKNC 853
C EG+ + + ++C+ Y S+ C D SC G P K C
Sbjct: 346 CHEGFALNPDK--KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.447
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,144,181
Number of Sequences: 37866
Number of extensions: 2017090
Number of successful extensions: 6263
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 5000
Number of HSP's gapped (non-prelim): 900
length of query: 913
length of database: 18,247,518
effective HSP length: 111
effective length of query: 802
effective length of database: 14,044,392
effective search space: 11263602384
effective search space used: 11263602384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.