Search of human proteins with 113422497

Search of human proteins with 113422497

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
         (578 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]         1160   0.0  
gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]         1160   0.0  
gi|169203012 PREDICTED: similar to hCG1820409 [Homo sapiens]          380   e-105
gi|5729718 trophoblast glycoprotein [Homo sapiens]                    205   1e-52
gi|194440719 chondroadherin-like [Homo sapiens]                       100   6e-21
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          99   8e-21
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]           98   2e-20
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    93   6e-19
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    93   6e-19
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    93   6e-19
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    93   6e-19
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              93   8e-19
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                    86   7e-17
gi|88702793 slit-like 2 [Homo sapiens]                                 84   3e-16
gi|13375646 leucine rich repeat and fibronectin type III domain ...    80   4e-15
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    79   9e-15
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 79   9e-15
gi|153791466 AMIGO protein [Homo sapiens]                              79   1e-14
gi|27363458 leucine rich repeat and fibronectin type III domain ...    77   4e-14
gi|4826772 insulin-like growth factor binding protein, acid labi...    75   2e-13
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    74   3e-13
gi|188528675 slit homolog 1 [Homo sapiens]                             73   6e-13
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          72   1e-12
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]                72   2e-12
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]           70   4e-12
gi|4759146 slit homolog 2 [Homo sapiens]                               70   5e-12
gi|11321571 slit homolog 3 [Homo sapiens]                              70   7e-12
gi|149773484 leucine rich repeat and fibronectin type III domain...    69   1e-11
gi|225579152 insulin-like growth factor binding protein, acid la...    69   2e-11
gi|116268101 leucine rich repeat containing 62 [Homo sapiens]          69   2e-11

>gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 1160 bits (3000), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60
           MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG
Sbjct: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60

Query: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120
           GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR
Sbjct: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120

Query: 121 DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN 180
           DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN
Sbjct: 121 DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN 180

Query: 181 SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA 240
           SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA
Sbjct: 181 SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA 240

Query: 241 SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN 300
           SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN
Sbjct: 241 SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN 300

Query: 301 HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL 360
           HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL
Sbjct: 301 HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL 360

Query: 361 DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL 420
           DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL
Sbjct: 361 DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL 420

Query: 421 PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR 480
           PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR
Sbjct: 421 PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR 480

Query: 481 CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC 540
           CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC
Sbjct: 481 CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC 540

Query: 541 RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL 578
           RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL
Sbjct: 541 RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL 578


>gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 1160 bits (3000), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60
           MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG
Sbjct: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60

Query: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120
           GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR
Sbjct: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120

Query: 121 DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN 180
           DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN
Sbjct: 121 DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTDRDCQPLRVKDSPHPCPPPGAPN 180

Query: 181 SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA 240
           SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA
Sbjct: 181 SLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCA 240

Query: 241 SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN 300
           SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN
Sbjct: 241 SGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHN 300

Query: 301 HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL 360
           HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL
Sbjct: 301 HIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAAL 360

Query: 361 DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL 420
           DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL
Sbjct: 361 DAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGL 420

Query: 421 PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR 480
           PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR
Sbjct: 421 PGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLR 480

Query: 481 CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC 540
           CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC
Sbjct: 481 CADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREAC 540

Query: 541 RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL 578
           RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL
Sbjct: 541 RDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL 578


>gi|169203012 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 339

 Score =  380 bits (977), Expect = e-105
 Identities = 192/198 (96%), Positives = 192/198 (96%), Gaps = 1/198 (0%)

Query: 382 RLPPA-ALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARP 440
           R P A A   ARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARP
Sbjct: 142 RKPEAGAQXXARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARP 201

Query: 441 LLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGEEAEAAGPEL 500
           LLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGEEAEAAGPEL
Sbjct: 202 LLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGEEAEAAGPEL 261

Query: 501 EASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREACRDQMEGYHYRYEQDADPRRA 560
           EASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREACRDQMEGYHYRYEQDADPRRA
Sbjct: 262 EASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREACRDQMEGYHYRYEQDADPRRA 321

Query: 561 PAPAAPAGSRATSPGSGL 578
           PAPAAPAGSRATSPGSGL
Sbjct: 322 PAPAAPAGSRATSPGSGL 339



 Score =  309 bits (792), Expect = 4e-84
 Identities = 151/158 (95%), Positives = 152/158 (96%)

Query: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60
           MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG
Sbjct: 1   MSNFLSPPLIPSSGSRSSSKVLPNPRILPGGDPPACSPQSGPAPHVLEKEEEGPSLNVGG 60

Query: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120
           GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR
Sbjct: 61  GGGGKPSRSLQEPNFSAARRGGGGEDEEKAQQPTALILGSLPPRLPRRGGRGDSAGGGGR 120

Query: 121 DREAGRGEANPAHSARSPERPRKPEAGAQDFRDSERTD 158
           DREAGRGEANPAHSARSPERPRKPEAGAQ     E+ D
Sbjct: 121 DREAGRGEANPAHSARSPERPRKPEAGAQXXARLEQLD 158


>gi|5729718 trophoblast glycoprotein [Homo sapiens]
          Length = 420

 Score =  205 bits (521), Expect = 1e-52
 Identities = 157/391 (40%), Positives = 197/391 (50%), Gaps = 71/391 (18%)

Query: 211 LVAAALSQPAAP--CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268
           L +A  +QP  P  CP  C C    + + +C +   L + P D+P   RNL + G  L V
Sbjct: 48  LASAVSAQPPLPDQCPALCECSEAARTV-KCVN-RNLTEVPTDLPAYVRNLFLTGNQLAV 105

Query: 269 LRAAAFAGGDGDGDQAAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPL 326
           L A AFA            R PL  L+AL L+ + ++ V  GAF+ LPSL  LDLSHNPL
Sbjct: 106 LPAGAFAR-----------RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154

Query: 327 RALGGGAFRGLPA-------LRSLQLNH------------------ALVRGGPAL--LAA 359
             L   AF G  A       L  L LNH                  A +  G AL  L  
Sbjct: 155 ADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRR 214

Query: 360 LDAA-----------LAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLD 407
           L+ A           LA L  LR L L+ N+L  L   + R L  LE L +  NAL  L 
Sbjct: 215 LELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH 274

Query: 408 PDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALL 467
              L  L+   GLP  R+ L +NP  C C    ++ WL+  TE V    RL CA P  + 
Sbjct: 275 NGTLAELQ---GLPHIRVFLDNNPWVCDCHMADMVTWLKE-TEVVQGKDRLTCAYPEKMR 330

Query: 468 DRPLLDLDGARLRCADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRR 527
           +R LL+L+ A L C                P L+ SYVF G+VLALIG IFL+VLYLNR+
Sbjct: 331 NRVLLELNSADLDCDP-----------ILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRK 379

Query: 528 GIQRWMRNLREACRDQMEGYHYRYEQDADPR 558
           GI++WM N+R+ACRD MEGYHYRYE +ADPR
Sbjct: 380 GIKKWMHNIRDACRDHMEGYHYRYEINADPR 410


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 107/290 (36%), Positives = 120/290 (41%), Gaps = 46/290 (15%)

Query: 232 GPKLLLRCASG--AELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289
           G  LLL  AS    EL Q   D     R L + G  L  LR   F              L
Sbjct: 110 GRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGA------------L 157

Query: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHAL 349
             L+ L L HN +  +   AF GL  +  L LSHN L  L   A  GLPALR L L+H  
Sbjct: 158 GALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNE 217

Query: 350 VRG--GPAL-----LAALDAALAPLA-----------ELRLLGLAGNALSRLPPAAL-RL 390
           ++   GP L     LA L+    PL             LR L L G AL  L P A    
Sbjct: 218 LQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHC 277

Query: 391 ARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATE 450
            RL  LD+R N L     D L  L+  G L   RL L  NPL CGC ARPLL WL  A  
Sbjct: 278 PRLHTLDLRGNQL-----DTLPPLQGPGQL--RRLRLQGNPLWCGCQARPLLEWLARARV 330

Query: 451 RVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGA--DARGEEAEAAGP 498
           R   +    C  PR L    L  L    LRC    A  +   EE   AGP
Sbjct: 331 RSDGA----CQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 96/294 (32%), Positives = 121/294 (41%), Gaps = 45/294 (15%)

Query: 209 LLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268
           LLL+A A    A  CP  C C    + +        L + P  +P   + L + G  L V
Sbjct: 19  LLLLAPARQAAAQRCPQACICDNSRRHV--ACRYQNLTEVPDAIPELTQRLDLQGNLLKV 76

Query: 269 LRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRA 328
           + AAAF G            +P L+ L L H  +E+V +GAF GL  L  L+L+ N LR 
Sbjct: 77  IPAAAFQG------------VPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124

Query: 329 LGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL 388
           L   A  GL +LR L+L       G AL          L  L  L LA NAL  LP  A 
Sbjct: 125 LPQEALDGLGSLRRLELE------GNALEELRPGTFGALGALATLNLAHNALVYLPAMAF 178

Query: 389 R-LARLEQLDVRLNALAGLDPDELRAL----------ERDGGLPGP---------RLLLA 428
           + L R+  L +  NAL+ L P+ L  L               LPGP         RL L 
Sbjct: 179 QGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELG 238

Query: 429 DNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRP---LLDLDGARL 479
            NPL        L   L    E + D   L+   PRA    P    LDL G +L
Sbjct: 239 HNPLTYAGEEDGLA--LPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQL 290



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 83/262 (31%), Positives = 105/262 (40%), Gaps = 47/262 (17%)

Query: 192 AGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRD 251
           A A   AP  G P   G         +  APCP  C C   P+       G  L+  PR 
Sbjct: 372 AVAGPRAPPRGPPRGPGE-------ERAVAPCPRACVCV--PESRHSSCEGCGLQAVPRG 422

Query: 252 VPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFD 311
            P D + L +   +   +  AAF G            L  L +L L H  I  +E GA  
Sbjct: 423 FPSDTQLLDLRRNHFPSVPRAAFPG------------LGHLVSLHLQHCGIAELEAGALA 470

Query: 312 GLPSLAALDLSHNPLRALGGGAFRGLPAL--------RSLQLNHALVRGGPAL--LAALD 361
           GL  L  L LS N L  L   A  G P L        R LQ+  A +R  P+L  L   D
Sbjct: 471 GLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQD 530

Query: 362 AALAPLA--------ELRLLGLAGNALSRLPPAALRLAR-LEQLDVRLNALAGLDPDELR 412
            A+  LA         LR + L+GN ++ +   AL  AR LE+L +  N L  +    L 
Sbjct: 531 NAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALE 590

Query: 413 ALERDGGLPG-PRLLLADNPLR 433
                 GLP    L L+ NPLR
Sbjct: 591 ------GLPALLELQLSGNPLR 606



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 67/203 (33%), Positives = 85/203 (41%), Gaps = 24/203 (11%)

Query: 278 DGDGDQAAGVRLPLLSALR---LTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAF 334
           D   D+ A   L    ALR   L+ N I  V  GA      L  L L  N LR +  GA 
Sbjct: 530 DNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGAL 589

Query: 335 RGLPALRSLQLNHALVRGGPALLAALDAALAPLA-ELRLLGLAGNALSRLPPAALRLARL 393
            GLPAL  LQL+      G  L A  D A  P+   L+ L L  + L ++ P A      
Sbjct: 590 EGLPALLELQLS------GNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGA-----F 638

Query: 394 EQLDVRLNALAGLDPDELRALERDGGLPGPRLL-LADNPLRCGCAARPLLAWLRNATERV 452
             L   L +L  L  ++LRAL     L    L+ L+ NP  C C   PL  WL     RV
Sbjct: 639 SGLGPGLQSL-HLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRV 697

Query: 453 -------PDSRRLRCAAPRALLD 468
                  P++R  R  A  A+ +
Sbjct: 698 GATCATPPNARGQRVKAAAAVFE 720


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 96/288 (33%), Positives = 126/288 (43%), Gaps = 34/288 (11%)

Query: 197 MAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDA 256
           MA RA  P L  LLL+   L   AA CP  C C+      + C +   LR  P  +PP  
Sbjct: 1   MALRA--PALLPLLLLLLPLR--AAGCPAACRCYSAT---VECGA-LRLRVVPLGIPPGT 52

Query: 257 RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSL 316
           + L +   N+  L   A A             L  L  L L +N +  +E GAF   P L
Sbjct: 53  QTLFLQDNNIARLEPGALAP------------LAALRRLYLHNNSLRALEAGAFRAQPRL 100

Query: 317 AALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLA 376
             L L+ N LR L  GAF GL  LR L L       G  L   LD     L  L+ L L 
Sbjct: 101 LELALTSNRLRGLRSGAFVGLAQLRVLYL------AGNQLARLLDFTFLHLPRLQELHLQ 154

Query: 377 GNALSRLPPAALR-LARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCG 435
            N++  L   AL  L+ L  LD+  N L  +  + L+ L          L L +NP RC 
Sbjct: 155 ENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPL-----ASLQVLRLTENPWRCD 209

Query: 436 CAARPLLAWLRNATERVPDS--RRLRCAAPRALLDRPLLDLDGARLRC 481
           CA   L AW++   +R+  S  R++ CA P  L  + LLD+  + L C
Sbjct: 210 CALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 81/266 (30%), Positives = 106/266 (39%), Gaps = 40/266 (15%)

Query: 237 LRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDG------DGDQAAGV--- 287
           LR       R  PR +      L +    L  LR+ AF G          G+Q A +   
Sbjct: 86  LRALEAGAFRAQPRLL-----ELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDF 140

Query: 288 ---RLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQ 344
               LP L  L L  N IE++ED A  GL SLA LDLS N L  +   A + L +L+ L+
Sbjct: 141 TFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLR 200

Query: 345 LNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALA 404
           L     R   A L  L A +    +  L       +   PP   RLA    LDV  ++L 
Sbjct: 201 LTENPWRCDCA-LHWLGAWIKEGGQRLLTSRDRKIMCAEPP---RLALQSLLDVSHSSLI 256

Query: 405 GLDPD-ELRALERDGGLPGPRLLLADNPLRCGCAA----RPLLAWLRNATERVPDSRRLR 459
            + P   ++ LE    L           LR  C A    +PL+ W      +VP  R  R
Sbjct: 257 CIPPSVHVQPLELTANL--------GEDLRVACQASGYPQPLVTW-----RKVPQPREGR 303

Query: 460 CAAPRALLDRPLLDLDGARLRCADSG 485
             A +A L+  LL L G       SG
Sbjct: 304 PRA-QAQLEGGLLGLGGHSASDTGSG 328


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 79/194 (40%), Positives = 92/194 (47%), Gaps = 15/194 (7%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           L AL L HN +  +  GAF G  +L  LDL  N L ++   AF GL AL+ L L+     
Sbjct: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS----- 127

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410
               L A      APL  LR L LAGN L+RL PAAL  L  L  L ++ N LA L P  
Sbjct: 128 -ANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186

Query: 411 LRALERDGGLPG-PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469
           L      G LP    L L  NP  CGCA RPL AWLR       ++  + C  P  L   
Sbjct: 187 L------GRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240

Query: 470 PLLDL-DGARLRCA 482
           PL    D A   CA
Sbjct: 241 PLTAFSDAAFSHCA 254



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 7/73 (9%)

Query: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALR 341
           A G   PL  L  L L  N +  +E  A   LP L +L L  N L AL  G    LPAL 
Sbjct: 135 APGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALD 194

Query: 342 SLQLNHALVRGGP 354
           +L L     RG P
Sbjct: 195 ALHL-----RGNP 202



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 32/96 (33%), Positives = 40/96 (41%), Gaps = 13/96 (13%)

Query: 231 GGPKLLLRCASGAELRQPPRDVPPDA-RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289
           G  +LL   A+  E   P    P  A RNL++ G  L  L  AA               L
Sbjct: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA------------L 166

Query: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325
           PLL +L L  N +  +  G    LP+L AL L  NP
Sbjct: 167 PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62

Query: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110

Query: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164

Query: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196

Query: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254

Query: 505 VF 506
            F
Sbjct: 255 AF 256


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62

Query: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110

Query: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164

Query: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196

Query: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254

Query: 505 VF 506
            F
Sbjct: 255 AF 256


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62

Query: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110

Query: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164

Query: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196

Query: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254

Query: 505 VF 506
            F
Sbjct: 255 AF 256


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62

Query: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110

Query: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164

Query: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196

Query: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254

Query: 505 VF 506
            F
Sbjct: 255 AF 256


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 93/290 (32%), Positives = 121/290 (41%), Gaps = 49/290 (16%)

Query: 218 QPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGG 277
           Q AAPCP  C C+  PK+   C     L+  P  +P  ++ + + G  ++ + AA+F   
Sbjct: 22  QVAAPCPGACVCYNEPKVTTSCPQQG-LQAVPVGIPAASQRIFLHGNRISHVPAASFRAC 80

Query: 278 DGDG------------DQAAGVRLPLLSALRLTHN-HIEVVEDGAFDGLPSLAALDLSHN 324
                           D AA   L LL  L L+ N  +  V+   F GL  L  L L   
Sbjct: 81  RNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRC 140

Query: 325 PLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLP 384
            L+ LG G FRGL AL+ L L         AL A  D     L  L  L L GN +S +P
Sbjct: 141 GLQELGPGLFRGLAALQYLYLQ------DNALQALPDDTFRDLGNLTHLFLHGNRISSVP 194

Query: 385 PAALR-LARLEQLDVRLNALAGLDPDELRALER----------DGGLPGPRLL------- 426
             A R L  L++L +  N +A + P   R L R             LP   L        
Sbjct: 195 ERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQY 254

Query: 427 --LADNPLRCGCAARPLLAWL---RNATERVPDSRRLRCAAPRALLDRPL 471
             L DNP  C C ARPL AWL   R ++  VP      C+ P+ L  R L
Sbjct: 255 LRLNDNPWVCDCRARPLWAWLQKFRGSSSEVP------CSLPQRLAGRDL 298


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 92/317 (29%), Positives = 127/317 (40%), Gaps = 66/317 (20%)

Query: 288 RLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNH 347
           RLP LS+L L+ NH+  +    F    +L  L L  NPL  L G  F  +  L+ L LN 
Sbjct: 240 RLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299

Query: 348 ALVRGGPAL-------LAALDAALAP------------LAELRLLGLAGNALSRLPPAAL 388
             +R  PA        L  L   L+P            L EL++L L  N L+ LP   L
Sbjct: 300 TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLL 359

Query: 389 R-LARLEQLDVRLNALAG----------------LDPDELRALERD--GGLPG-PRLLLA 428
           R L +L Q+ +R N L                  LD ++L  L  D  G LP    +LL 
Sbjct: 360 RGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLG 419

Query: 429 DNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRC------- 481
            N  RC C   P L WLR     V      RCA P A    PL  L G    C       
Sbjct: 420 HNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPP 479

Query: 482 ----ADSGADARGEEAEA----------------AGPELEASYVFFGLVLALIGLIFLMV 521
               ADS ++A    A A                 G +    + F+ L+LA+  +I +++
Sbjct: 480 PRPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVII 539

Query: 522 LYLNRRGIQRWMRNLRE 538
           ++   +  Q + + +RE
Sbjct: 540 VFAMIKIGQLFRKLIRE 556



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 66/230 (28%), Positives = 96/230 (41%), Gaps = 35/230 (15%)

Query: 206 LQGLLLVAAA--LSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263
           L+G LL A    L     PCP  C C    +   +C+ G   R     +P +  ++ + G
Sbjct: 2   LRGTLLCAVLGLLRAQPFPCPPACKCVF--RDAAQCSGGDVARISALGLPTNLTHILLFG 59

Query: 264 ANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSH 323
               VL++ +F+G            + +L  L ++ +HI  V  G F  L  L  L LS 
Sbjct: 60  MGRGVLQSQSFSG------------MTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107

Query: 324 NPLRALGGGAFRGLPALRSLQLNHALVRG-----------------GPALLAALDAAL-A 365
           N +  L G     +  L  L L+H  +RG                     L  L A+L  
Sbjct: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFT 167

Query: 366 PLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDELRAL 414
            L  L+LL L+GN L+ LP   L   A+LE+L +  N L  LD   L +L
Sbjct: 168 NLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSL 217


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 102/342 (29%), Positives = 130/342 (38%), Gaps = 73/342 (21%)

Query: 210 LLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVL 269
           LL+  AL      CP  C C     +      G  +   PRDVPPD   L +    +T+L
Sbjct: 11  LLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTV---PRDVPPDTVGLYVFENGITML 67

Query: 270 RAAAFAGGDG------DGDQAA----GVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLA 317
            A +FAG  G        +Q A    GV  PL  LS L LT N +  + +  F GL  L 
Sbjct: 68  DAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLE 127

Query: 318 ALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPAL--------------LAALDAA 363
            L L  N +R +  GAF  L  L  L+L    +R  P L              L AL+  
Sbjct: 128 RLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPG 187

Query: 364 LAPLAELRLLGLAG------------------------NALSRLPPAALRLARLEQLDVR 399
           +   A +  L LAG                        N L R+PP    L  L +L + 
Sbjct: 188 ILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLA 247

Query: 400 LNA-LAGLDPDELRAL----ERD------GGLPG------PRLLL---ADNPLRCGCAAR 439
            N  +A L P++L  L    E D        LPG      PRL L   A NP  C C   
Sbjct: 248 GNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLS 307

Query: 440 PLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRC 481
               W+R +   +      RC  P     R LL+LD A   C
Sbjct: 308 WFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGC 349


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 96/293 (32%), Positives = 118/293 (40%), Gaps = 49/293 (16%)

Query: 204 PGLQGLLLVAAALSQPAA----PCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNL 259
           P L  LL +A A S P +    PCP +C C      L     GA L   P  +   A  L
Sbjct: 5   PLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAEL 64

Query: 260 TIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAAL 319
            +    +  +R    A   G            L  L L+ N I  V  GAF  L +L AL
Sbjct: 65  RLADNFIASVRRRDLANMTG------------LLHLSLSRNTIRHVAAGAFADLRALRAL 112

Query: 320 DLSHNPLRALGGGAFRGLPALRSLQLNH----ALVRGG----PALLAALD---------- 361
            L  N L +LG G  RGL  LR L L++    AL  G        L  LD          
Sbjct: 113 HLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLP 172

Query: 362 -AALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPD----ELRALE 415
             AL  L  +  LGL  N L+ +P  A  RL +L +LD+  N L  + PD     L  L 
Sbjct: 173 WEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLA 232

Query: 416 RDGGLPGPRLLLA--DNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRAL 466
           R  G P   L+LA   NPL C C     L WLR       +     CA+P AL
Sbjct: 233 RPRGSPASALVLAFGGNPLHCNCE----LVWLRRLAR---EDDLEACASPPAL 278


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 71/218 (32%), Positives = 88/218 (40%), Gaps = 27/218 (12%)

Query: 204 PGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263
           PG   L      L++PA PCP  C CF          S  EL   P D+PP  +N+  V 
Sbjct: 3   PGAWLLWTSLLLLARPAQPCPMGCDCFVQEVF----CSDEELATVPLDIPPYTKNIIFVE 58

Query: 264 ANLTVLRAAAFAGGDG--------------DGDQAAGVRLPLLSALRLTHNHIEVVEDGA 309
            + T L   AF                     D   G  LP L  L +T +    +    
Sbjct: 59  TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGG--LPRLEDLEVTGSSFLNLSTNI 116

Query: 310 FDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAE 369
           F  L SL  L L+ N L AL  G F+ L AL SL L       G  L A       PL  
Sbjct: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQ------GNQLQALPRRLFQPLTH 170

Query: 370 LRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGL 406
           L+ L LA N L++LP      L  L+ L +  NAL+GL
Sbjct: 171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 61/191 (31%), Positives = 86/191 (45%), Gaps = 13/191 (6%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           L+ L L  N + V+  G F   P L  L L+HN L  +  G F  L  LRSL L++  + 
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLDPDE 410
             PA           L EL  L L  N L+ L PA  + L++LE L +  N L  L P+ 
Sbjct: 327 HLPA------GIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL-PEG 379

Query: 411 LRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRP 470
           +     D       L L  NP +C C    L  WL+  T+R+ + +   CA P  L  + 
Sbjct: 380 I----FDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY-CAGPAYLKGQV 434

Query: 471 LLDLDGARLRC 481
           +  L+  +L C
Sbjct: 435 VPALNEKQLVC 445



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 34/113 (30%), Positives = 48/113 (42%), Gaps = 7/113 (6%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           L  L L  N +  + +  F  L SL  L LS+N L  L  G F  L +L+ L L+   + 
Sbjct: 171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS 230

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNAL 403
             P          + L  L  L L  NA++ LP +    L  L  L ++ N L
Sbjct: 231 ELP------PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 102/348 (29%), Positives = 129/348 (37%), Gaps = 56/348 (16%)

Query: 204 PGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263
           P    LLL+  AL   A  CP  C C+  P  +   A+       P  +PP  + L +  
Sbjct: 12  PASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANN--FSSVPLSLPPSTQRLFLQN 69

Query: 264 ANLTVLRAAAFAGG--------DGDGDQAAGV--RLPLLSALRLTHN-HIEVVEDGAFDG 312
             +  LR   F           +       G    L  L  L L  N H+  +E   F G
Sbjct: 70  NLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQG 129

Query: 313 LPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRL 372
           L  L +L L    L +L G  FRGL +L+ L L         +LL   D   A LA L  
Sbjct: 130 LERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQE------NSLLHLQDDLFADLANLSH 183

Query: 373 LGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLDPDELRALER----------DGGLP 421
           L L GN L  L     R L  L++L +  N L G+     R L R             LP
Sbjct: 184 LFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLP 243

Query: 422 GPRLL---------LADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLL 472
           G  L          L  NP  C C ARPL AW + A  RV  S  + CA P     R L 
Sbjct: 244 GEALADLPSLEFLRLNANPWACDCRARPLWAWFQRA--RV-SSSDVTCATPPERQGRDLR 300

Query: 473 DLDGARLRCAD------SGADARGEE--------AEAAGPELEASYVF 506
            L  A  +          G+ ARG          AEA  P  + S ++
Sbjct: 301 ALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLY 348


>gi|153791466 AMIGO protein [Homo sapiens]
          Length = 493

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 76/242 (31%), Positives = 103/242 (42%), Gaps = 38/242 (15%)

Query: 204 PGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263
           P L  LL   A   +    CP  C C      +L C S  +L   P  +P     L +  
Sbjct: 15  PSLSLLLFEVARAGRAVVSCPAACLCASN---ILSC-SKQQLPNVPHSLPSYTALLDLSH 70

Query: 264 ANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSH 323
            NL+ LRA           +    RL  L +L L+HNH+  +   AF  +P+L  LDLS 
Sbjct: 71  NNLSRLRA-----------EWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSS 119

Query: 324 NPLRALGGGAFRGLPALRSLQL--NHALVRGGPALLAALDAALAPLAELRLLGLAGNALS 381
           N LR L    F  L  L  L L  NH        ++A    A   +A+L+ L L+ N +S
Sbjct: 120 NQLRTLDEFLFSDLQVLEVLLLYNNH--------IMAVDRCAFDDMAQLQKLYLSQNQIS 171

Query: 382 RLP----PAALRLARLEQLDVRLNALAGL---DPDELRALERDGGLPGPRLLLADNPLRC 434
           R P        +L +L  LD+  N L  L   D  +L A  ++G      L L +NPL C
Sbjct: 172 RFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNG------LYLHNNPLNC 225

Query: 435 GC 436
            C
Sbjct: 226 DC 227


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 94/299 (31%), Positives = 121/299 (40%), Gaps = 77/299 (25%)

Query: 211 LVAAALSQPAAPCPFQCYCFG-GPKLLLRCASGAELRQPP----RDV------------- 252
           L+   L+  AA CP  C C      L   CA    L  PP    R V             
Sbjct: 5   LLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALG 64

Query: 253 PPDARNLT-IVGANLT---VLRAAAFAGGDG--------DGDQ-----AAGVRLPL-LSA 294
           PPD RN+T +V   L+   + R  A A GD         DG++        +R P+ L  
Sbjct: 65  PPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQH 124

Query: 295 LRLTHNHIEVVEDGAFDG-LPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGG 353
           L L+ N +  +  GAFD  L SL  LDLS+N LR +       +PAL +L L+H      
Sbjct: 125 LILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDH------ 178

Query: 354 PALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDELR 412
                                   N +  LPP A  +L +L +LD+  N LA L PD L 
Sbjct: 179 ------------------------NLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLF 214

Query: 413 ALERDG-GLPGPRLL-LADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469
           +  RD    P P +L  + NPL C C     L WLR      PD     CA+P  L  R
Sbjct: 215 SRGRDAEASPAPLVLSFSGNPLHCNCE----LLWLRRLAR--PDDLE-TCASPPGLAGR 266


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 84/250 (33%), Positives = 107/250 (42%), Gaps = 37/250 (14%)

Query: 197 MAPRAGQPGLQGLLLVAAAL-------SQPAAP-------CPFQCYCF---GGPKLLLRC 239
           MA R G   L  LLL   AL       + P  P       CP  C C       +L + C
Sbjct: 1   MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC 60

Query: 240 ASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFA-----------GGD-GDGDQAAGV 287
           +S   L + P  VP   + L + G NL+ +  AAF            GG  G  +  A +
Sbjct: 61  SS-RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119

Query: 288 RLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNH 347
            L  L  L L  N +  +  G F   P+LA+L LS+N L  L  G F GL +L  L L  
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL-- 177

Query: 348 ALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGL 406
               G  +L    DAA   L  LR L LAGN L+ L PA    LA L +LD+  NAL  +
Sbjct: 178 ----GWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233

Query: 407 DPDELRALER 416
             +    L R
Sbjct: 234 KANVFVQLPR 243



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 51/144 (35%), Positives = 66/144 (45%), Gaps = 19/144 (13%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLN----- 346
           L  L L HN ++ V+ GAF GL ++A ++LS N LR L    FRGL  L SL L      
Sbjct: 340 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG 399

Query: 347 -------------HALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LAR 392
                          L      L+   + +L  LAEL  L L  N L+ LP    + L +
Sbjct: 400 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459

Query: 393 LEQLDVRLNALAGLDPDELRALER 416
           LE L +  N LA L  D L  L+R
Sbjct: 460 LEYLLLSRNRLAELPADALGPLQR 483



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 7/127 (5%)

Query: 289 LPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHA 348
           L  L  L+L HN I  + + +F+GL  L  L L HN L+ +  GAF GL  +  + L+  
Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372

Query: 349 LVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLD 407
            +R  P      +     L +L  L L G+ L R+ P     L+ L +L ++ N L G++
Sbjct: 373 CLRNLP------EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 426

Query: 408 PDELRAL 414
              L  L
Sbjct: 427 EQSLWGL 433



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 66/231 (28%), Positives = 86/231 (37%), Gaps = 60/231 (25%)

Query: 257 RNLTIVGANLTVLRAAAFAG----GDGDGDQAA--------GVRLPLLSALRLTHNHIEV 304
           R L + G  L  L+ A F+G     + D  + A         V+LP L  L L  N I  
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 256

Query: 305 VEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRG------------ 352
           V  GAF GL +L  LDLSHN +  L    F GL  LR L+L+H  +              
Sbjct: 257 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 316

Query: 353 ---------------------GPALLAALD---------AALAPLAELRLLGLAGNALSR 382
                                G   +  LD          A   L  + ++ L+GN L  
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRN 376

Query: 383 LPPAALR-LARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPL 432
           LP    R L +L  L +  + L  + P     L    GL   RL L DN L
Sbjct: 377 LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL---SGL--RRLFLKDNGL 422


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 70/224 (31%), Positives = 93/224 (41%), Gaps = 24/224 (10%)

Query: 195 AAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPP 254
           AA AP+   P    LL +          CP  C C   P+ +L      +L   P  +P 
Sbjct: 3   AATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVL--CGHRQLEAVPGGLPL 60

Query: 255 DARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLP 314
           D   L + G  L  L+    +            RL LL  L L++N +  +E GAF GL 
Sbjct: 61  DTELLDLSGNRLWGLQQGMLS------------RLSLLQELDLSYNQLSTLEPGAFHGLQ 108

Query: 315 SLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLG 374
           SL  L L  N LR +G G F GL AL  L L          ++  LD A   L  L+ L 
Sbjct: 109 SLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRL------NQIVLFLDGAFGELGSLQKLE 162

Query: 375 LAGNALSRLPPAALR-LARLEQLDV---RLNALAGLDPDELRAL 414
           +  N L  + P A   LA+L  L +    L+ + GL    L AL
Sbjct: 163 VGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPAL 206



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 44/154 (28%), Positives = 57/154 (37%), Gaps = 38/154 (24%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           LS+L +T  ++  V   A   L  L  LDLS NP+ A+       L  L+ L+L+     
Sbjct: 254 LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLS----- 308

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDEL 411
            G  L +    A   L    LL +A NAL  L   A                    PD+L
Sbjct: 309 -GACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFP-----------------SPDKL 350

Query: 412 RALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445
             L            L+ NPL C C     L WL
Sbjct: 351 VTLR-----------LSGNPLTCDCR----LLWL 369



 Score = 33.9 bits (76), Expect = 0.42
 Identities = 39/120 (32%), Positives = 54/120 (45%), Gaps = 5/120 (4%)

Query: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385
           L  L GG+    PA+         V  G   L A+   L PL +  LL L+GN L  L  
Sbjct: 20  LLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGL-PL-DTELLDLSGNRLWGLQQ 77

Query: 386 AAL-RLARLEQLDVRLNALAGLDPDELRALER--DGGLPGPRLLLADNPLRCGCAARPLL 442
             L RL+ L++LD+  N L+ L+P     L+      L G RL +    +  G +A  LL
Sbjct: 78  GMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLL 137


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 67/261 (25%), Positives = 105/261 (40%), Gaps = 52/261 (19%)

Query: 223 CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGD 282
           CP +C C      ++ C+S  +L + P  +P     L +    +++L A           
Sbjct: 513 CPHKCRCEAN---VVECSS-LKLTKIPERIPQSTAELRLNNNEISILEATGMFK------ 562

Query: 283 QAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRS 342
                +L  L  + L++N +  +EDGAF+G  S++ L L+ N L ++  G FRGL  LR+
Sbjct: 563 -----KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRT 617

Query: 343 LQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNA 402
           L L +  +          + +   L  +RLL L  N ++ + P A               
Sbjct: 618 LMLRNNRIS------CIHNDSFTGLRNVRLLSLYDNQITTVSPGAF-------------- 657

Query: 403 LAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAA 462
                 D L++L          L L  NP  C C    L  WLR   +R   +   RC  
Sbjct: 658 ------DTLQSLS--------TLNLLANPFNCNCQLAWLGGWLR---KRKIVTGNPRCQN 700

Query: 463 PRALLDRPLLDLDGARLRCAD 483
           P  L   PL D+     RC +
Sbjct: 701 PDFLRQIPLQDVAFPDFRCEE 721



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/293 (24%), Positives = 115/293 (39%), Gaps = 53/293 (18%)

Query: 209 LLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268
           LLL AAA    A+ CP  C C G     + C  G  L+  P+++P +   L + G N+T 
Sbjct: 20  LLLWAAAWRLGASACPALCTCTG---TTVDC-HGTGLQAIPKNIPRNTERLELNGNNITR 75

Query: 269 LRAAAFAGGD------------GDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSL 316
           +    FAG              G  ++ A   +  L  LRL  N + ++ +  F    +L
Sbjct: 76  IHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQAL 135

Query: 317 AALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLA 376
           + LDLS N ++A+   AFRG   L++LQL+   +          + A   L  L +L L 
Sbjct: 136 SRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS------CIEEGAFRALRGLEVLTLN 189

Query: 377 GNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGC 436
            N ++ +P ++                      +LR              L  N L C C
Sbjct: 190 NNNITTIPVSSFN-----------------HMPKLRTFR-----------LHSNHLFCDC 221

Query: 437 AARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADAR 489
               L  WLR   +R       +C+ P +L    + ++  +   C+  G   R
Sbjct: 222 HLAWLSQWLR---QRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGR 271



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 61/210 (29%), Positives = 94/210 (44%), Gaps = 24/210 (11%)

Query: 279 GDGDQAAGVRLP-LLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGL 337
           G G  A    LP  ++ +RL  N I+ +  GAF     L  +DLS+N +  +   AF+GL
Sbjct: 297 GKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGL 356

Query: 338 PALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR----LARL 393
            +L SL L    +   P            L  L+LL L  N ++ + P A +    L+ L
Sbjct: 357 RSLNSLVLYGNKITDLPR------GVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLL 410

Query: 394 EQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVP 453
              D ++ +LA      LRA++         L LA NP  C C     L WL +     P
Sbjct: 411 SLYDNKIQSLAKGTFTSLRAIQ--------TLHLAQNPFICDCN----LKWLADFLRTNP 458

Query: 454 -DSRRLRCAAPRALLDRPLLDLDGARLRCA 482
            ++   RCA+PR L ++ +  +   + RC+
Sbjct: 459 IETSGARCASPRRLANKRIGQIKSKKFRCS 488



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 23/162 (14%)

Query: 219 PAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGD 278
           P   CP +C C      ++RC S   LR  P+ +P +   L + G   T++         
Sbjct: 730 PRPQCPQECACLD---TVVRC-SNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLST--- 782

Query: 279 GDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLP 338
                        L  + L++N I  + + +F  +  L  L LS+N L+ +   AF+GL 
Sbjct: 783 ----------FKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR 832

Query: 339 ALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNAL 380
           +LR L L+      G  +    +   A +  L  L +  N L
Sbjct: 833 SLRLLSLH------GNDISTLQEGIFADVTSLSHLAIGANPL 868


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 99/374 (26%), Positives = 135/374 (36%), Gaps = 84/374 (22%)

Query: 172 PCPPPGAPNSLVSAAARALDAGAAAMAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFG 231
           PCPP   P   +S    AL        P     G   +   A   S PA  CP  C C  
Sbjct: 8   PCPP--LPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSN 65

Query: 232 GPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPL 291
               ++   +  +L + P  +P + R L +    + V+R   F              L  
Sbjct: 66  QASRVI--CTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFK------------HLRH 111

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           L  L+L+ N +  +E GAF+GLPSL  L+L  N L  +   AF  L  LR L L +  + 
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171

Query: 352 GGPAL-------LAALD------------AALAPLAELRLLGLAGNALSRLPPAALRLAR 392
             P+        L  LD            AA   L  LR L L    L  +P     L R
Sbjct: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLT-ALVR 230

Query: 393 LEQLDVRLNALAGLDP---------------------------DELRALERDG------- 418
           LE+L++  N L  + P                           D+L++LE          
Sbjct: 231 LEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLM 290

Query: 419 GLPG---------PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRR--LRCAAPRALL 467
            LP           R+ L  NP  C C    L  WL+   E VP +     RC AP  L 
Sbjct: 291 SLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK---ETVPSNTTCCARCHAPAGLK 347

Query: 468 DRPLLDLDGARLRC 481
            R + +LD +   C
Sbjct: 348 GRYIGELDQSHFTC 361


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 74/208 (35%), Positives = 92/208 (44%), Gaps = 28/208 (13%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           LS+L L+ N+++ +    F  LP L  L L  N L  L   AF GL ALR L+L      
Sbjct: 231 LSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLE----- 285

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410
            G  L     A L PL  L  L L+GN LS L PA    L RL +L +R NAL+ L  D 
Sbjct: 286 -GNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344

Query: 411 LRALERDGGLPGP---RLLLADNPLRCGCAARPLLAWLRNATERVPDSRRL----RCAAP 463
             A         P   RL L  N   C C  R L  W+ +   +    R L    +C  P
Sbjct: 345 FAA--------SPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQ---GRLLTVFVQCRHP 393

Query: 464 RALLDRPLLDLDGARLR---CADSGADA 488
            AL  + L  LD  +L+   CAD    A
Sbjct: 394 PALRGKYLDYLDDQQLQNGSCADPSPSA 421



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 58/171 (33%), Positives = 70/171 (40%), Gaps = 33/171 (19%)

Query: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPL--------------- 326
           A G   PL  L  L    N I  +  G+F+GL SL  L L  N L               
Sbjct: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182

Query: 327 ---------RALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAG 377
                    R LG  AF  L  LR L L+   ++  P+L  A  A  APL  L  L L+ 
Sbjct: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ--PSLRHA--ATFAPLRSLSSLILSA 238

Query: 378 NALSRLPPAALR-LARLEQLDVRLNALAGLDPDELRALE--RDGGLPGPRL 425
           N L  L P   + L RL  L +R N L  L P+    LE  R+  L G RL
Sbjct: 239 NNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 38/105 (36%), Positives = 51/105 (48%), Gaps = 8/105 (7%)

Query: 310 FDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAE 369
           F  L  L  LDL +N +R+L    F  L  L  L L + L++      A     LAPL +
Sbjct: 79  FHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ------ALAPGTLAPLRK 132

Query: 370 LRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLDPDELRA 413
           LR+L   GN +SRL   +   L  L +L +  NAL  L PD + A
Sbjct: 133 LRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGAL-PDAVFA 176



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 43/117 (36%), Positives = 50/117 (42%), Gaps = 17/117 (14%)

Query: 259 LTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAA 318
           L++ G  LT L   AF G            L  L  LRL  N +  +     + L SL A
Sbjct: 258 LSLRGNQLTHLAPEAFWG------------LEALRELRLEGNRLSQLPTALLEPLHSLEA 305

Query: 319 LDLSHNPLRALGGGAFRGLPALRSLQL-NHALVRGGPALLAALDAALAPLAELRLLG 374
           LDLS N L AL    F  L  LR L L N+AL     AL   + AA   L  L L G
Sbjct: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNAL----SALSGDIFAASPALYRLDLDG 358


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 83/271 (30%), Positives = 103/271 (38%), Gaps = 58/271 (21%)

Query: 210 LLVAAAL--SQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLT 267
           LL+AA L  S     CP  C C      ++ C+S      PP D+P D RNL+       
Sbjct: 66  LLLAAGLMHSDAGTSCPVLCTC---RNQVVDCSSQRLFSVPP-DLPMDTRNLS------- 114

Query: 268 VLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLR 327
                                        L HN I  V  G       L  LDL +N L 
Sbjct: 115 -----------------------------LAHNRITAVPPGYLTCYMELQVLDLHNNSLM 145

Query: 328 ALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNA-LSRLPPA 386
            L  G F     L  L L++      PA +      L  +       L+ N  L R+ P 
Sbjct: 146 ELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHI------DLSHNPWLRRVHPQ 199

Query: 387 ALR-LARLEQLDVRLNALAGLDPDELRALERDGGLPG-PRLLLADNPLRCGCAARPLLAW 444
           A + L +L  LD+    LA L    L ALE   GLPG   L +  NP  CGC   PLL W
Sbjct: 200 AFQGLMQLRDLDLSYGGLAFLS---LEALE---GLPGLVTLQIGGNPWVCGCTMEPLLKW 253

Query: 445 LRNATER-VPDSRRLRCAAPRALLDRPLLDL 474
           LRN  +R   DS+   C  P  +   PL  L
Sbjct: 254 LRNRIQRCTADSQLAECRGPPEVEGAPLFSL 284


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 59/190 (31%), Positives = 88/190 (46%), Gaps = 23/190 (12%)

Query: 211 LVAAALSQPAAP-CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVL 269
           LV A L++ A   CP QC C G     + C  G  LR  PR++P +   L + G N+T +
Sbjct: 15  LVLAILNKVAPQACPAQCSCSGST---VDC-HGLALRSVPRNIPRNTERLDLNGNNITRI 70

Query: 270 RAAAFAG------------GDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLA 317
               FAG                 ++ A   L  L  LRL  NH+++  +  F G   L 
Sbjct: 71  TKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLY 130

Query: 318 ALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAG 377
            LDLS N ++A+   AFRG   +++LQL++  +          D A   L +L +L L  
Sbjct: 131 RLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQIS------CIEDGAFRALRDLEVLTLNN 184

Query: 378 NALSRLPPAA 387
           N ++RL  A+
Sbjct: 185 NNITRLSVAS 194



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 56/196 (28%), Positives = 87/196 (44%), Gaps = 23/196 (11%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351
           ++ +RL  N I+V+  GAF     L  +DLS+N +  L   AF+GL +L SL L      
Sbjct: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY----- 356

Query: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR----LARLEQLDVRLNALAGLD 407
            G  +     +    L  L+LL L  N ++ L   A +    L  L   D +L  +A   
Sbjct: 357 -GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGT 415

Query: 408 PDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVP-DSRRLRCAAPRAL 466
              LRA++         + LA NP  C C     L WL +     P ++   RC +PR L
Sbjct: 416 FSPLRAIQ--------TMHLAQNPFICDCH----LKWLADYLHTNPIETSGARCTSPRRL 463

Query: 467 LDRPLLDLDGARLRCA 482
            ++ +  +   + RC+
Sbjct: 464 ANKRIGQIKSKKFRCS 479



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 67/267 (25%), Positives = 101/267 (37%), Gaps = 56/267 (20%)

Query: 223 CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGD 282
           CP +C C G     + C S  +L + P  +P     L +     TVL A           
Sbjct: 506 CPEKCRCEG---TTVDC-SNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK------ 555

Query: 283 QAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRS 342
                +LP L  +  ++N I  +E+GAF+G   +  + L+ N L  +    F+GL +L++
Sbjct: 556 -----KLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKT 610

Query: 343 LQL--NHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRL 400
           L L  N     G  + +         L+ +RLL L  N ++ + P A             
Sbjct: 611 LMLRSNRITCVGNDSFIG--------LSSVRLLSLYDNQITTVAPGAF------------ 650

Query: 401 NALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRC 460
                   D L +L          L L  NP  C C    L  WLR   +R+      RC
Sbjct: 651 --------DTLHSLS--------TLNLLANPFNCNCYLAWLGEWLRK--KRIVTGNP-RC 691

Query: 461 AAPRALLDRPLLDLDGARLRCADSGAD 487
             P  L + P+ D+      C D   D
Sbjct: 692 QKPYFLKEIPIQDVAIQDFTCDDGNDD 718



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/263 (22%), Positives = 93/263 (35%), Gaps = 78/263 (29%)

Query: 219 PAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGD 278
           P + CP +C C      ++RC S   L+  P+ +P D   L + G   T++         
Sbjct: 723 PLSRCPTECTCLD---TVVRC-SNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELS---- 774

Query: 279 GDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLP 338
                        L+ + L++N I  + + +F  +  L  L LS+N LR +    F GL 
Sbjct: 775 ---------NYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLK 825

Query: 339 ALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDV 398
           +LR                              LL L GN +S +P  A           
Sbjct: 826 SLR------------------------------LLSLHGNDISVVPEGAF---------- 845

Query: 399 RLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRL 458
                     ++L AL          L +  NPL C C  + L  W+++      +    
Sbjct: 846 ----------NDLSALSH--------LAIGANPLYCDCNMQWLSDWVKS---EYKEPGIA 884

Query: 459 RCAAPRALLDRPLLDLDGARLRC 481
           RCA P  + D+ LL     +  C
Sbjct: 885 RCAGPGEMADKLLLTTPSKKFTC 907



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/52 (38%), Positives = 31/52 (59%)

Query: 295 LRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLN 346
           L+L +N I  +EDGAF  L  L  L L++N +  L   +F  +P LR+ +L+
Sbjct: 156 LQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLH 207


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 72/240 (30%), Positives = 101/240 (42%), Gaps = 31/240 (12%)

Query: 210 LLVAAALS-QPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268
           L +A+ LS  PA  CP +C C       + C  G  LR  PR +P +A  L +   N+T 
Sbjct: 20  LALASVLSGPPAVACPTKCTCSAAS---VDC-HGLGLRAVPRGIPRNAERLDLDRNNITR 75

Query: 269 LRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRA 328
           +    FAG            L  L  L L  N + V+E GAF  L  L  L L+ N L+ 
Sbjct: 76  ITKMDFAG------------LKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV 123

Query: 329 LGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL 388
           L    F+  P L  L L+   ++G P        A   + +++ L L  N +S +   A 
Sbjct: 124 LPELLFQSTPKLTRLDLSENQIQGIPR------KAFRGITDVKNLQLDNNHISCIEDGAF 177

Query: 389 RLAR-LEQLDVRLNALAGLDPDELRALERDGGLPGPRLL-LADNPLRCGCAARPLLAWLR 446
           R  R LE L +  N ++ +       +     +P  R L L  N L C C    L  WLR
Sbjct: 178 RALRDLEILTLNNNNISRI------LVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLR 231



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 68/252 (26%), Positives = 104/252 (41%), Gaps = 52/252 (20%)

Query: 223 CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGD 282
           CP +C C G    ++ C S  +L + P  +P    +L +    ++VL A           
Sbjct: 505 CPEKCRCEG---TIVDC-SNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFK------ 554

Query: 283 QAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRS 342
                +LP L  + L++N I+ V +GAFDG  S+  L L+ N L  + G  FRGL  L++
Sbjct: 555 -----KLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKT 609

Query: 343 LQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNA 402
           L L   L+          +   A L+ +RLL L  N ++ + P A            L +
Sbjct: 610 LMLRSNLIG------CVSNDTFAGLSSVRLLSLYDNRITTITPGAF---------TTLVS 654

Query: 403 LAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAA 462
           L+ ++                   L  NP  C C    L  WLR   +R   S   RC  
Sbjct: 655 LSTIN-------------------LLSNPFNCNCHLAWLGKWLR---KRRIVSGNPRCQK 692

Query: 463 PRALLDRPLLDL 474
           P  L + P+ D+
Sbjct: 693 PFFLKEIPIQDV 704



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 66/259 (25%), Positives = 98/259 (37%), Gaps = 78/259 (30%)

Query: 223 CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGD 282
           CP QC C    + ++RC S   LR  PR +P D   L + G +LT +     A       
Sbjct: 725 CPEQCTCM---ETVVRC-SNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSA------- 773

Query: 283 QAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRS 342
                 L  L+ + L++N I ++ +  F  +  L+ L LS+N LR +   AF GL +LR 
Sbjct: 774 ------LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRV 827

Query: 343 LQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNA 402
           L L+                              GN +S +P  +             N 
Sbjct: 828 LTLH------------------------------GNDISSVPEGS------------FND 845

Query: 403 LAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAA 462
           L  L                  L L  NPL C C+ R L  W++   +   +    RC++
Sbjct: 846 LTSLS----------------HLALGTNPLHCDCSLRWLSEWVKAGYK---EPGIARCSS 886

Query: 463 PRALLDRPLLDLDGARLRC 481
           P  + DR LL     R +C
Sbjct: 887 PEPMADRLLLTTPTHRFQC 905



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 56/196 (28%), Positives = 89/196 (45%), Gaps = 25/196 (12%)

Query: 295 LRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGP 354
           +RL  N I+ +  GAF     L  +D+S N +  +   AF+GL +L SL L       G 
Sbjct: 312 IRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLY------GN 365

Query: 355 ALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRAL 414
            +          L  L+LL L  N ++      LR+   + L   LN L+  D ++L+ +
Sbjct: 366 KITEIAKGLFDGLVSLQLLLLNANKIN-----CLRVNTFQDLQ-NLNLLSLYD-NKLQTI 418

Query: 415 ERDGGLPGP-----RLLLADNPLRCGCAARPLLAWLRNATERVP-DSRRLRCAAPRALLD 468
            +  GL  P      L LA NP  C C     L WL +  +  P ++   RC++PR L +
Sbjct: 419 SK--GLFAPLQSIQTLHLAQNPFVCDCH----LKWLADYLQDNPIETSGARCSSPRRLAN 472

Query: 469 RPLLDLDGARLRCADS 484
           + +  +   + RC+ S
Sbjct: 473 KRISQIKSKKFRCSGS 488


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 90/290 (31%), Positives = 114/290 (39%), Gaps = 55/290 (18%)

Query: 209 LLLVAAALSQPAAPCPFQCYCFG-GPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLT 267
           LLL+ A  S+   PCP +C C    P L + CA    L  PP      A +  +V   LT
Sbjct: 21  LLLLWAGASR-GQPCPGRCICQNVAPTLTMLCAKTGLLFVPP------AIDRRVVELRLT 73

Query: 268 VLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLR 327
               AA    D          +  L  L L+ N I  V  GAF  L +L AL L  N L 
Sbjct: 74  DNFIAAVRRRD-------FANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126

Query: 328 ALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAA 387
            + G   RGL  LR L L +  +R   +  AA DA L+ + +   L L+ N L  LP  A
Sbjct: 127 EVRGDQLRGLGNLRHLILGNNQIRRVES--AAFDAFLSTVED---LDLSYNNLEALPWEA 181

Query: 388 -------------------------LRLARLEQLDVRLNALAGLDPDELRALERDGGLPG 422
                                    ++L +L +LD+  N L  L PD L    +  G   
Sbjct: 182 VGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKP 241

Query: 423 PRLL---LADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469
           P  L      NPL C C     L WLR  T    +     CA P  L DR
Sbjct: 242 PTPLTVSFGGNPLHCNCE----LLWLRRLTR---EDDLETCATPEHLTDR 284


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 81/285 (28%), Positives = 113/285 (39%), Gaps = 58/285 (20%)

Query: 174 PPPGAPNSLVSAAARALDAGAAAMAPRA---GQPGLQGLLLVAAALSQPAAPCPFQCYCF 230
           PPP A       A   L     A+ PR+     PG  G              CP  C C 
Sbjct: 35  PPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPG--------EAEGPACPAACVCS 86

Query: 231 ---GGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDG------ 281
                 +L + C+S   L + P  VP   + L + G NL+ +  AAF      G      
Sbjct: 87  YDDDADELSVFCSS-RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQG 145

Query: 282 ------------------------DQAAGVRL------PLLSALRLTHNHIEVVEDGAFD 311
                                   +Q   + L      P L++L L++N +  +EDG F+
Sbjct: 146 GQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFE 205

Query: 312 GLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELR 371
           GL SL  L+L  N L  L   AFRGL +LR       LV  G  L     A  + LAELR
Sbjct: 206 GLGSLWDLNLGWNSLAVLPDAAFRGLGSLRE------LVLAGNRLAYLQPALFSGLAELR 259

Query: 372 LLGLAGNALSRLPP-AALRLARLEQLDVRLNALAGLDPDELRALE 415
            L L+ NAL  +     ++L RL++L +  N +A + P     L+
Sbjct: 260 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK 304



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 51/144 (35%), Positives = 66/144 (45%), Gaps = 19/144 (13%)

Query: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLN----- 346
           L  L L HN ++ V+ GAF GL ++A ++LS N LR L    FRGL  L SL L      
Sbjct: 378 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG 437

Query: 347 -------------HALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LAR 392
                          L      L+   + +L  LAEL  L L  N L+ LP    + L +
Sbjct: 438 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497

Query: 393 LEQLDVRLNALAGLDPDELRALER 416
           LE L +  N LA L  D L  L+R
Sbjct: 498 LEYLLLSRNRLAELPADALGPLQR 521



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 7/127 (5%)

Query: 289 LPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHA 348
           L  L  L+L HN I  + + +F+GL  L  L L HN L+ +  GAF GL  +  + L+  
Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410

Query: 349 LVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLD 407
            +R  P      +     L +L  L L G+ L R+ P     L+ L +L ++ N L G++
Sbjct: 411 CLRNLP------EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 464

Query: 408 PDELRAL 414
              L  L
Sbjct: 465 EQSLWGL 471



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 66/231 (28%), Positives = 86/231 (37%), Gaps = 60/231 (25%)

Query: 257 RNLTIVGANLTVLRAAAFAG----GDGDGDQAA--------GVRLPLLSALRLTHNHIEV 304
           R L + G  L  L+ A F+G     + D  + A         V+LP L  L L  N I  
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 294

Query: 305 VEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRG------------ 352
           V  GAF GL +L  LDLSHN +  L    F GL  LR L+L+H  +              
Sbjct: 295 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 354

Query: 353 ---------------------GPALLAALD---------AALAPLAELRLLGLAGNALSR 382
                                G   +  LD          A   L  + ++ L+GN L  
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRN 414

Query: 383 LPPAALR-LARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPL 432
           LP    R L +L  L +  + L  + P     L    GL   RL L DN L
Sbjct: 415 LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL---SGL--RRLFLKDNGL 460


>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
          Length = 820

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 77/266 (28%), Positives = 104/266 (39%), Gaps = 48/266 (18%)

Query: 211 LVAAALSQPAAPCPFQ--CYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTI--VGANL 266
           L AAAL     P   +  C+   G K  +  A  ++  QPP +  P   N T+  +  N 
Sbjct: 6   LCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQ-NQPPYETIPQHINSTVHDLRLNE 64

Query: 267 TVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPL 326
             L+A  ++  +  G+         L+ L LT N I  +EDGAF G  SL  L L +N L
Sbjct: 65  NKLKAVLYSSLNRFGN---------LTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKL 115

Query: 327 RALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPA 386
             L  G  RG+  L+ L + H L+            A +    L  + L+ N LSRL  A
Sbjct: 116 SNLTEGMLRGMSRLQFLFVQHNLIE------VVTPTAFSECPSLISIDLSSNRLSRLDGA 169

Query: 387 ALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLR 446
                          +LA L   E                LA NP  C C     LAWL 
Sbjct: 170 TFA------------SLASLMVCE----------------LAGNPFNCECDLFGFLAWLV 201

Query: 447 NATERVPDSRRLRCAAPRALLDRPLL 472
                  +  RL+C +PR     PLL
Sbjct: 202 VFNNVTKNYDRLQCESPREFAGYPLL 227


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,251,639
Number of Sequences: 37866
Number of extensions: 1705200
Number of successful extensions: 13590
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 613
Number of HSP's that attempted gapping in prelim test: 10710
Number of HSP's gapped (non-prelim): 2674
length of query: 578
length of database: 18,247,518
effective HSP length: 108
effective length of query: 470
effective length of database: 14,157,990
effective search space: 6654255300
effective search space used: 6654255300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.