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Search of human proteins with 20336199
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo
sapiens]
(1708 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 3425 0.0
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 3425 0.0
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 3423 0.0
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 228 5e-59
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 223 9e-58
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 177 1e-43
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 173 1e-42
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 133 1e-30
gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad... 119 3e-26
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 112 4e-24
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 112 4e-24
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 72 4e-12
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 59 5e-08
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 53 3e-06
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 51 8e-06
gi|4507691 transformation/transcription domain-associated protei... 51 1e-05
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 48 7e-05
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 48 9e-05
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 45 5e-04
gi|169207319 PREDICTED: hypothetical protein [Homo sapiens] 41 0.011
gi|169207756 PREDICTED: hypothetical protein [Homo sapiens] 41 0.011
gi|169207046 PREDICTED: hypothetical protein [Homo sapiens] 41 0.011
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 40 0.015
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 40 0.015
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 38 0.074
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 38 0.074
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 38 0.096
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 36 0.28
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 36 0.37
gi|83716024 kinesin family member 21B [Homo sapiens] 35 0.48
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 3425 bits (8881), Expect = 0.0
Identities = 1708/1708 (100%), Positives = 1708/1708 (100%)
Query: 1 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 60
MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL
Sbjct: 1 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 60
Query: 61 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 120
SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV
Sbjct: 61 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 120
Query: 121 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 180
IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV
Sbjct: 121 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 180
Query: 181 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 240
YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF
Sbjct: 181 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 240
Query: 241 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 300
SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV
Sbjct: 241 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 300
Query: 301 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 360
VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL
Sbjct: 301 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 360
Query: 361 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 420
QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR
Sbjct: 361 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 420
Query: 421 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 480
TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK
Sbjct: 421 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 480
Query: 481 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 540
PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN
Sbjct: 481 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 540
Query: 541 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 600
LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC
Sbjct: 541 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 600
Query: 601 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 660
AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI
Sbjct: 601 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 660
Query: 661 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 720
YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL
Sbjct: 661 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 720
Query: 721 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 780
QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL
Sbjct: 721 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 780
Query: 781 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 840
YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL
Sbjct: 781 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 840
Query: 841 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 900
FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK
Sbjct: 841 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 900
Query: 901 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 960
DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA
Sbjct: 901 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 960
Query: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 1020
LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA
Sbjct: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 1020
Query: 1021 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 1080
GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR
Sbjct: 1021 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 1080
Query: 1081 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 1140
EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC
Sbjct: 1081 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 1140
Query: 1141 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 1200
SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI
Sbjct: 1141 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 1200
Query: 1201 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 1260
SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT
Sbjct: 1201 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 1260
Query: 1261 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 1320
IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME
Sbjct: 1261 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 1320
Query: 1321 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 1380
IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM
Sbjct: 1321 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 1380
Query: 1381 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 1440
QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH
Sbjct: 1381 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 1440
Query: 1441 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 1500
KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK
Sbjct: 1441 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 1500
Query: 1501 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 1560
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF
Sbjct: 1501 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 1560
Query: 1561 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 1620
RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL
Sbjct: 1561 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 1620
Query: 1621 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 1680
YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV
Sbjct: 1621 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 1680
Query: 1681 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
GGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 1681 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 3425 bits (8881), Expect = 0.0
Identities = 1708/1708 (100%), Positives = 1708/1708 (100%)
Query: 1 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 60
MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL
Sbjct: 1349 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 1408
Query: 61 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 120
SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV
Sbjct: 1409 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 1468
Query: 121 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 180
IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV
Sbjct: 1469 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 1528
Query: 181 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 240
YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF
Sbjct: 1529 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 1588
Query: 241 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 300
SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV
Sbjct: 1589 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 1648
Query: 301 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 360
VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL
Sbjct: 1649 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 1708
Query: 361 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 420
QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR
Sbjct: 1709 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 1768
Query: 421 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 480
TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK
Sbjct: 1769 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 1828
Query: 481 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 540
PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN
Sbjct: 1829 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 1888
Query: 541 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 600
LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC
Sbjct: 1889 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 1948
Query: 601 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 660
AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI
Sbjct: 1949 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 2008
Query: 661 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 720
YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL
Sbjct: 2009 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 2068
Query: 721 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 780
QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL
Sbjct: 2069 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 2128
Query: 781 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 840
YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL
Sbjct: 2129 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 2188
Query: 841 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 900
FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK
Sbjct: 2189 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 2248
Query: 901 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 960
DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA
Sbjct: 2249 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 2308
Query: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 1020
LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA
Sbjct: 2309 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 2368
Query: 1021 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 1080
GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR
Sbjct: 2369 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 2428
Query: 1081 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 1140
EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC
Sbjct: 2429 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 2488
Query: 1141 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 1200
SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI
Sbjct: 2489 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 2548
Query: 1201 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 1260
SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT
Sbjct: 2549 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 2608
Query: 1261 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 1320
IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME
Sbjct: 2609 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 2668
Query: 1321 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 1380
IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM
Sbjct: 2669 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 2728
Query: 1381 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 1440
QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH
Sbjct: 2729 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 2788
Query: 1441 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 1500
KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK
Sbjct: 2789 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 2848
Query: 1501 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 1560
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF
Sbjct: 2849 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 2908
Query: 1561 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 1620
RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL
Sbjct: 2909 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 2968
Query: 1621 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 1680
YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV
Sbjct: 2969 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 3028
Query: 1681 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
GGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 3029 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 3423 bits (8876), Expect = 0.0
Identities = 1707/1708 (99%), Positives = 1708/1708 (100%)
Query: 1 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 60
MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL
Sbjct: 1227 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 1286
Query: 61 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 120
SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV
Sbjct: 1287 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 1346
Query: 121 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 180
IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV
Sbjct: 1347 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 1406
Query: 181 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 240
YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF
Sbjct: 1407 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 1466
Query: 241 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 300
SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV
Sbjct: 1467 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 1526
Query: 301 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 360
VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL
Sbjct: 1527 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 1586
Query: 361 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 420
QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR
Sbjct: 1587 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 1646
Query: 421 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 480
TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK
Sbjct: 1647 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 1706
Query: 481 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 540
PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN
Sbjct: 1707 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 1766
Query: 541 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 600
LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC
Sbjct: 1767 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 1826
Query: 601 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 660
AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI
Sbjct: 1827 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 1886
Query: 661 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 720
YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL
Sbjct: 1887 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 1946
Query: 721 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 780
QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL
Sbjct: 1947 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 2006
Query: 781 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 840
YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL
Sbjct: 2007 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 2066
Query: 841 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 900
FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK
Sbjct: 2067 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 2126
Query: 901 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 960
DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA
Sbjct: 2127 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 2186
Query: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 1020
LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA
Sbjct: 2187 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 2246
Query: 1021 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 1080
GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR
Sbjct: 2247 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 2306
Query: 1081 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 1140
EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC
Sbjct: 2307 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 2366
Query: 1141 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 1200
SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI
Sbjct: 2367 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 2426
Query: 1201 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 1260
SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT
Sbjct: 2427 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 2486
Query: 1261 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 1320
IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME
Sbjct: 2487 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 2546
Query: 1321 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 1380
IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM
Sbjct: 2547 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 2606
Query: 1381 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 1440
QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH
Sbjct: 2607 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 2666
Query: 1441 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 1500
KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK
Sbjct: 2667 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 2726
Query: 1501 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 1560
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF
Sbjct: 2727 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 2786
Query: 1561 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 1620
RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL
Sbjct: 2787 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 2846
Query: 1621 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 1680
YLQQRPEDETELHPTLNADDQECKRNLSDIDQSF+KVAERVLMRLQEKLKGVEEGTVLSV
Sbjct: 2847 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFDKVAERVLMRLQEKLKGVEEGTVLSV 2906
Query: 1681 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
GGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 2907 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 2934
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 228 bits (580), Expect = 5e-59
Identities = 163/548 (29%), Positives = 257/548 (46%), Gaps = 53/548 (9%)
Query: 1181 TKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVP 1240
T + F + LISRI H H +F++L A FL P+ A V
Sbjct: 2130 TNYLAPYQFLTAFSQLISRIC--HSHDEVFVVLMEIIAK--VFLAYPQQAMWMMTA--VS 2183
Query: 1241 KQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLD----------ATQW 1290
K S + +R + ++ + V L D + L N +T +
Sbjct: 2184 KSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHF 2243
Query: 1291 KTQRKGINIPADQPITKLKNLEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFR 1343
K +K + I L L+ V++PT+ H G+ I F
Sbjct: 2244 KMLKKLVEEATFSEI--LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVE 2301
Query: 1344 LAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLT 1403
+ + PK I GSDGK + K +DDLR+D + + + N L+++ E+R+R+L
Sbjct: 2302 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELH 2361
Query: 1404 ICTYKVVPLSQRSGVLEWCTGTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQ 1461
I TY V+PL+ G++EW T + L E G + + ++ M +
Sbjct: 2362 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPK 2413
Query: 1462 KKSFEEKYEVFMD-VCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGL 1520
+ EK +VF + + P+F + + F DP W+ R AY RS A S+VGYILGL
Sbjct: 2414 SAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGL 2473
Query: 1521 GDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR 1580
GDRH +NIL + + E VH+D F +G+ PE VPFRLT ++V+GMG G EG+FR
Sbjct: 2474 GDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFR 2533
Query: 1581 RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADD 1640
R CE TM +MR+ +E L+++++ L+DPL +W+ P+K + L+ T +
Sbjct: 2534 RACEVTMRLMRDQREPLMSVLKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVN 2585
Query: 1641 QECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRL 1700
++ K ++ DI+Q V K + G LS+ G V+ LIQ+A D L ++
Sbjct: 2586 EKAKTHVLDIEQRLQGVI---------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQM 2636
Query: 1701 FPGWKAWV 1708
+ GW ++
Sbjct: 2637 YLGWTPYM 2644
Score = 119 bits (298), Expect = 3e-26
Identities = 198/919 (21%), Positives = 368/919 (40%), Gaps = 135/919 (14%)
Query: 145 LCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN 204
LCC + C +L +H ++ L+PL++ Q K+ + YL+I+N+D
Sbjct: 1191 LCCRAWDCFVRCLDHACLGSLLSH---VIVALLPLIHIQ---PKETAAIFHYLIIENRDA 1244
Query: 205 ENLYI-TIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRL 263
++ I L PDH K ++ Q+ + + L+ ++ R+
Sbjct: 1245 VQDFLHEIYFL---PDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRI 1301
Query: 264 EGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAV 323
L L+ L +K+Q I A+ + I+ +LV LL+ + A +
Sbjct: 1302 HALTSLKETL--YKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDA-----NSQARLLC 1354
Query: 324 GSCLGEVGPID-----FSTIAIQHSKDASYTKALKLFEDKELQWTFIM------LTYLNN 372
G CLGE+G ID FST Q KD ++ + ED + +M L Y +N
Sbjct: 1355 GECLGELGAIDPGRLDFSTTETQ-GKDFTFVTGV---EDSSFAYGLLMELTRAYLAYADN 1410
Query: 373 TLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRF 432
+ +D + + + +T ++++ + + L+P +R K +
Sbjct: 1411 SRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQ---- 1466
Query: 433 DKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEV--KTDFC 490
K + G+ L N W + + + ++ + C + K DF
Sbjct: 1467 -KSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITK--VRHDLASKIFTCCSIMMKHDFK 1523
Query: 491 QTV--LPYLIHDILL----QDTNESWRNLLST---------HVQGFFTSCLRHFSQTSRS 535
T+ LP+++ +LL +D E + +++ + Q + + +QT S
Sbjct: 1524 VTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFS 1583
Query: 536 TTPANLDSESEHFFRC-----CLDKKSQR----TMLAVVDYMRRQKRPSSGTIFNDAFWL 586
+L + H F+ C KS R +M++ VDY Q S T F D
Sbjct: 1584 MLD-HLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQ----SVTRFLDLIPQ 1638
Query: 587 DLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSK 646
D +A + A+ A+++ E + +K + QE L F
Sbjct: 1639 DT----LAVASFRSKAYTRAVMHFESFITEKKQNIQEH--LGF----------------- 1675
Query: 647 EETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETA 706
L ++Y ++ EPD + G + +P + + EHE++ T + A
Sbjct: 1676 ----------LQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRA 1725
Query: 707 IPSSTRQA----GIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWD 762
I Q G+++++ LG + + G+ +W EL +AAW+ QWD
Sbjct: 1726 IQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWD 1785
Query: 763 HCTS-VSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLE--SVY 819
+ ++ + + T++ L L S + R+ + FY+SLK R +++ + S E S
Sbjct: 1786 LVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQ 1845
Query: 820 SLYPTLSRLQAIGELE-SIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMAL 878
Y + RL + ELE SI LF S E + W ++ ++S + +EPI+AL
Sbjct: 1846 RGYEYIVRLHMLCELEHSIKPLFQHSPGDSS-QEDSLNWVARLEMTQNS-YRAKEPILAL 1903
Query: 879 RTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSC 938
R +L + + + EC ++ + +AR + Q A+ N+
Sbjct: 1904 RRALLSLNKRPDYNEMVGEC--------WLQSARVARKAGHHQTAYNALL-----NAGES 1950
Query: 939 GVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANN---PSLK--LTYTECLRVC 993
++E +E A+ W+K + AL +L++ ++ C N P K L + + +
Sbjct: 1951 RLAELYVERAKWLWSKGDVHQALIVLQKGVE----LCFPENETPPEGKNMLIHGRAMLLV 2006
Query: 994 GNWLAETCLENPAVIMQTY 1012
G ++ ET IM+ Y
Sbjct: 2007 GRFMEETANFESNAIMKKY 2025
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 223 bits (569), Expect = 9e-58
Identities = 133/408 (32%), Positives = 210/408 (51%), Gaps = 35/408 (8%)
Query: 1311 LEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKE 1363
L+ V++PT+ H G+ I F + + PK I GSDGK
Sbjct: 4 LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF 63
Query: 1364 RRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT 1423
+ K +DDLR+D + + + N L+++ E+R+R+L I TY V+PL+ G++EW
Sbjct: 64 YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN 123
Query: 1424 GTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD-VCQNFQ 1480
T + L E G + + ++ M + + EK +VF + +
Sbjct: 124 NTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPKSAALSEKLKVFREFLLPRHP 175
Query: 1481 PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
P+F + + F DP W+ R AY RS A S+VGYILGLGDRH +NIL + + E VH+
Sbjct: 176 PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHV 235
Query: 1541 DLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTI 1600
D F +G+ PE VPFRLT ++V+GMG G EG+FRR CE TM +MR+ +E L+++
Sbjct: 236 DFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSV 295
Query: 1601 VEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAER 1660
++ L+DPL +W+ P+K + L+ T +++ K ++ DI+Q V
Sbjct: 296 LKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVNEKAKTHVLDIEQRLQGVI-- 345
Query: 1661 VLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
K + G LS+ G V+ LIQ+A D L +++ GW ++
Sbjct: 346 -------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 177 bits (448), Expect = 1e-43
Identities = 121/407 (29%), Positives = 199/407 (48%), Gaps = 45/407 (11%)
Query: 1332 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 1391
++ IQS ++ P+ + +GS+G E L+KG +DLRQD + Q+F + NTLL
Sbjct: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
Query: 1392 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH---KRYRPNDF 1448
+ + ++ L+I Y V+PLS SG++ W V + D H + YR
Sbjct: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGW-----------VPHCDTLHALIRDYREKKK 2258
Query: 1449 SAFQCQKKMMEVQKKSFE-----EKYEVFMDVCQNFQ-PVFRYFCMEKFLDPAIWFEKRL 1502
+ ++M ++ +K EVF N K +WF++R
Sbjct: 2259 ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT 2318
Query: 1503 AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFR 1561
YTRS+A S+VGYILGLGDRH N++++ S +++HID G FE PE +PFR
Sbjct: 2319 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 2378
Query: 1562 LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM---NPLK 1618
LTR + + M +TG++G +R C MEV+R +++++ ++E +YDPL +W + N
Sbjct: 2379 LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438
Query: 1619 ALYLQQRPE-----DETELHPTLNADDQECKRNLSDIDQS--------------FNKVAE 1659
+ R + E+ + + K+ + + +S NK A
Sbjct: 2439 NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI 2498
Query: 1660 RVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW 1704
+++ R+++KL G L V QV LLI+QA +NL + + GW
Sbjct: 2499 QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
Score = 33.5 bits (75), Expect = 1.8
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 3/153 (1%)
Query: 688 YEHEAMWGKALVTYD--LETAIPSSTRQAGIIQALQNLGLCHILSVYL-KGLDYENKDWC 744
YE W ALV YD ++T G ++ L+ LG L + N +
Sbjct: 1450 YEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQ 1509
Query: 745 PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV 804
++ + AAW QWD + + ++ + Y A+ +L FS + + AR
Sbjct: 1510 AKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD 1569
Query: 805 KEVEEMCKRSLESVYSLYPTLSRLQAIGELESI 837
E+ + ES Y + + ELE +
Sbjct: 1570 LLDAELTAMAGESYSRAYGAMVSCHMLSELEEV 1602
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 173 bits (439), Expect = 1e-42
Identities = 109/317 (34%), Positives = 157/317 (49%), Gaps = 45/317 (14%)
Query: 1333 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 1392
VTI S + PK + +GSDGK L KG +DL D + Q + NT+
Sbjct: 2119 VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA 2178
Query: 1393 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 1452
+ Y V PL RSG+++W G P+ G +KR++ + +A Q
Sbjct: 2179 TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLF--------GLYKRWQQRE-AALQ 2229
Query: 1453 CQKKMMEVQK--------KSFEEKYE----------VFMDVCQNFQPVF-RYFCMEKFLD 1493
QK Q + E Y + +DV + P+ +E+ ++
Sbjct: 2230 AQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2289
Query: 1494 -----------------PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAE 1536
P W+ +Y RS A S+VGYI+GLGDRH+ N+LI+ + E
Sbjct: 2290 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGE 2349
Query: 1537 LVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET 1596
+VHID V FE+GK L PE VPFR+T++I +G+TGVEGVFR CE+ + +MR +ET
Sbjct: 2350 VVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRET 2409
Query: 1597 LLTIVEVLLYDPLFDWT 1613
LLT++E +YDPL DWT
Sbjct: 2410 LLTLLEAFVYDPLVDWT 2426
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/59 (38%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 1652 QSFNKVAERVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
Q N A V R++ KL+G V+ +SV QV+ +I++A + NL++L+ GW AWV
Sbjct: 3603 QERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3661
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 133 bits (335), Expect = 1e-30
Identities = 112/420 (26%), Positives = 178/420 (42%), Gaps = 52/420 (12%)
Query: 1333 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 1392
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3717 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3776
Query: 1393 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 1452
+++ +R L + TY VVP++ R G++EW TV + + L+N K +D A
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPP 3836
Query: 1453 CQKK--MMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFL--------------DPAI 1496
C+ K + ++ K Y + + V + E + P
Sbjct: 3837 CEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEA 3896
Query: 1497 WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTP 1555
+ R + S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP P
Sbjct: 3897 FLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3956
Query: 1556 ETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMN 1615
E +PFRLTR ++ M G+ + R+ L ++V + +P FDW
Sbjct: 3957 ELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNF 4016
Query: 1616 PLKAL-----YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL-------- 1662
K L ++Q+ E +P KR L+ + + E +L
Sbjct: 4017 EQKMLKKGGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAF 4074
Query: 1663 --------------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4075 RDYVAVARGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4128
>gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 2105
Score = 119 bits (298), Expect = 3e-26
Identities = 198/919 (21%), Positives = 368/919 (40%), Gaps = 135/919 (14%)
Query: 145 LCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN 204
LCC + C +L +H ++ L+PL++ Q K+ + YL+I+N+D
Sbjct: 949 LCCRAWDCFVRCLDHACLGSLLSH---VIVALLPLIHIQ---PKETAAIFHYLIIENRDA 1002
Query: 205 ENLYI-TIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRL 263
++ I L PDH K ++ Q+ + + L+ ++ R+
Sbjct: 1003 VQDFLHEIYFL---PDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRI 1059
Query: 264 EGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAV 323
L L+ L +K+Q I A+ + I+ +LV LL+ + A +
Sbjct: 1060 HALTSLKETL--YKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDA-----NSQARLLC 1112
Query: 324 GSCLGEVGPID-----FSTIAIQHSKDASYTKALKLFEDKELQWTFIM------LTYLNN 372
G CLGE+G ID FST Q KD ++ + ED + +M L Y +N
Sbjct: 1113 GECLGELGAIDPGRLDFSTTETQ-GKDFTFVTGV---EDSSFAYGLLMELTRAYLAYADN 1168
Query: 373 TLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRF 432
+ +D + + + +T ++++ + + L+P +R K +
Sbjct: 1169 SRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQ---- 1224
Query: 433 DKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEV--KTDFC 490
K + G+ L N W + + + ++ + C + K DF
Sbjct: 1225 -KSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITK--VRHDLASKIFTCCSIMMKHDFK 1281
Query: 491 QTV--LPYLIHDILL----QDTNESWRNLLST---------HVQGFFTSCLRHFSQTSRS 535
T+ LP+++ +LL +D E + +++ + Q + + +QT S
Sbjct: 1282 VTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFS 1341
Query: 536 TTPANLDSESEHFFRC-----CLDKKSQR----TMLAVVDYMRRQKRPSSGTIFNDAFWL 586
+L + H F+ C KS R +M++ VDY Q S T F D
Sbjct: 1342 MLD-HLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQ----SVTRFLDLIPQ 1396
Query: 587 DLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSK 646
D +A + A+ A+++ E + +K + QE L F
Sbjct: 1397 DT----LAVASFRSKAYTRAVMHFESFITEKKQNIQEH--LGF----------------- 1433
Query: 647 EETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETA 706
L ++Y ++ EPD + G + +P + + EHE++ T + A
Sbjct: 1434 ----------LQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRA 1483
Query: 707 IPSSTRQA----GIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWD 762
I Q G+++++ LG + + G+ +W EL +AAW+ QWD
Sbjct: 1484 IQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWD 1543
Query: 763 HCTS-VSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLE--SVY 819
+ ++ + + T++ L L S + R+ + FY+SLK R +++ + S E S
Sbjct: 1544 LVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQ 1603
Query: 820 SLYPTLSRLQAIGELE-SIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMAL 878
Y + RL + ELE SI LF S E + W ++ ++S + +EPI+AL
Sbjct: 1604 RGYEYIVRLHMLCELEHSIKPLFQHSPGDSS-QEDSLNWVARLEMTQNS-YRAKEPILAL 1661
Query: 879 RTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSC 938
R +L + + + EC ++ + +AR + Q A+ N+
Sbjct: 1662 RRALLSLNKRPDYNEMVGEC--------WLQSARVARKAGHHQTAYNALL-----NAGES 1708
Query: 939 GVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANN---PSLK--LTYTECLRVC 993
++E +E A+ W+K + AL +L++ ++ C N P K L + + +
Sbjct: 1709 RLAELYVERAKWLWSKGDVHQALIVLQKGVE----LCFPENETPPEGKNMLIHGRAMLLV 1764
Query: 994 GNWLAETCLENPAVIMQTY 1012
G ++ ET IM+ Y
Sbjct: 1765 GRFMEETANFESNAIMKKY 1783
Score = 38.9 bits (89), Expect = 0.043
Identities = 53/225 (23%), Positives = 83/225 (36%), Gaps = 25/225 (11%)
Query: 1181 TKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVP 1240
T + F + LISRI H H +F++L A FL P+ A V
Sbjct: 1888 TNYLAPYQFLTAFSQLISRIC--HSHDEVFVVLMEIIAK--VFLAYPQQAMWMMTA--VS 1941
Query: 1241 KQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLD----------ATQW 1290
K S + +R + ++ + V L D + L N +T +
Sbjct: 1942 KSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHF 2001
Query: 1291 KTQRKGINIPADQPITKLKNLEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFR 1343
K +K + I L L+ V++PT+ H G+ I F
Sbjct: 2002 KMLKKLVEEATFSEI--LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVE 2059
Query: 1344 LAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCN 1388
+ + PK I GSDGK + K +DDLR+D + + + N
Sbjct: 2060 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLIN 2104
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 112 bits (279), Expect = 4e-24
Identities = 105/413 (25%), Positives = 171/413 (41%), Gaps = 69/413 (16%)
Query: 1333 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 1392
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3717 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3776
Query: 1393 RNTETRKRKLTICTYKVVPLSQRSG------VLEWCT---GTVPIGEFLVNNEDGAHKRY 1443
+++ +R L + TY VVP++ +W T G +G +++ + GA++
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYK-GANRTE 3835
Query: 1444 RPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLA 1503
F + K ++ K++F + P + R
Sbjct: 3836 TVTSFRKRE-SKVPADLLKRAF----------------------VRMSTSPEAFLALRSH 3872
Query: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRL 1562
+ S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP PE +PFRL
Sbjct: 3873 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRL 3932
Query: 1563 TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL-- 1620
TR ++ M G+ + R+ L ++V + +P FDW K L
Sbjct: 3933 TRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKK 3992
Query: 1621 ---YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL--------------- 1662
++Q+ E +P KR L+ + + E +L
Sbjct: 3993 GGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVA 4050
Query: 1663 -------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4051 RGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4097
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 112 bits (279), Expect = 4e-24
Identities = 105/413 (25%), Positives = 171/413 (41%), Gaps = 69/413 (16%)
Query: 1333 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 1392
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3716 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3775
Query: 1393 RNTETRKRKLTICTYKVVPLSQRSG------VLEWCT---GTVPIGEFLVNNEDGAHKRY 1443
+++ +R L + TY VVP++ +W T G +G +++ + GA++
Sbjct: 3776 QDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYK-GANRTE 3834
Query: 1444 RPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLA 1503
F + K ++ K++F + P + R
Sbjct: 3835 TVTSFRKRE-SKVPADLLKRAF----------------------VRMSTSPEAFLALRSH 3871
Query: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRL 1562
+ S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP PE +PFRL
Sbjct: 3872 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRL 3931
Query: 1563 TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL-- 1620
TR ++ M G+ + R+ L ++V + +P FDW K L
Sbjct: 3932 TRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKK 3991
Query: 1621 ---YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL--------------- 1662
++Q+ E +P KR L+ + + E +L
Sbjct: 3992 GGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVA 4049
Query: 1663 -------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4050 RGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4096
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 72.4 bits (176), Expect = 4e-12
Identities = 74/307 (24%), Positives = 127/307 (41%), Gaps = 57/307 (18%)
Query: 1360 DGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 1419
DG + + K DDLRQD ++ Q+ + + LL++ E KLT YKV+ S + G +
Sbjct: 627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK--ENLDLKLT--PYKVLATSTKHGFM 682
Query: 1420 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 1479
++ +VP+ E L D +
Sbjct: 683 QFIQ-SVPVAEVL-----------------------------------------DTEGSI 700
Query: 1480 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 1539
Q FR + + I E Y +S A ++ YILG+GDRH+ N+L+ ++ +L H
Sbjct: 701 QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFH 759
Query: 1540 IDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETL 1597
ID G + P P P +L +++V+GMG T E FR+ C +R +
Sbjct: 760 IDFGYILGRD---PKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
Query: 1598 LTIVEVLLYDPLFDWTMNPLKALYLQQRP-----EDETELHPTLNADDQECKRNLSDIDQ 1652
L + +++ + D + P K + Q DE +H + D+ + + +
Sbjct: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
Query: 1653 SFNKVAE 1659
+K A+
Sbjct: 877 QIHKFAQ 883
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 58.5 bits (140), Expect = 5e-08
Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 47/246 (19%)
Query: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426
+ K DDLRQD + Q+ ++ + L + L + Y + RSG++E + +
Sbjct: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKE----AGLDLRMLPYGCLATGDRSGLIEVVSTSE 858
Query: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486
I + +N+ + A +A K + K + +
Sbjct: 859 TIADIQLNSSNVA---------AAAAFNKDALLNWLKEYNSGDD---------------- 893
Query: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 1544
LD AI +T S A + Y+LG+GDRH NI++ +++ +L HID G +
Sbjct: 894 -----LDRAIE-----EFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHIL 942
Query: 1545 AFEQGKILPTPETVPFRLTRDIVDGM-----GITGVEGVFRRCCEKTMEVMRNSQETLLT 1599
+ K E VPF LT D + + G T G FR+CCE ++R +T
Sbjct: 943 GNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 1002
Query: 1600 IVEVLL 1605
+ ++L
Sbjct: 1003 LFALML 1008
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 52.8 bits (125), Expect = 3e-06
Identities = 63/232 (27%), Positives = 94/232 (40%), Gaps = 47/232 (20%)
Query: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426
+ K DDLRQD + Q+ Q+ + L ++ L + Y +P R+G++E +
Sbjct: 777 IFKNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTGLIEVVLRSD 832
Query: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486
I +N + A +AF + ++ K+ E
Sbjct: 833 TIANIQLNKSNMAAT-------AAFNKDALLNWLKSKNPGEA------------------ 867
Query: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 1544
LD AI +T S A + Y+LG+GDRH NI+I E S +L HID G +
Sbjct: 868 -----LDRAIE-----EFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDFGHFL 916
Query: 1545 AFEQGKILPTPETVPFRLTRDIVD--GMGITGVEGVFRR---CCEKTMEVMR 1591
+ K E VPF LT D V G T F R CE+ ++R
Sbjct: 917 GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 51.2 bits (121), Expect = 8e-06
Identities = 62/249 (24%), Positives = 99/249 (39%), Gaps = 54/249 (21%)
Query: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW---CT 1423
+ K DDLRQD ++ Q+ ++ ++ ET L + Y + + G++E T
Sbjct: 831 IFKHGDDLRQDMLILQILRIMESIW----ETESLDLCLLPYGCISTGDKIGMIEIVKDAT 886
Query: 1424 GTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVF 1483
I + V N GA K N + +K EEK++ ++
Sbjct: 887 TIAKIQQSTVGNT-GAFKDEVLNHWLK----------EKSPTEEKFQAAVE--------- 926
Query: 1484 RYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG 1543
R Y S A + ++LG+GDRH NI+I E + L HID G
Sbjct: 927 -----------------RFVY--SCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG 966
Query: 1544 VAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVE-----GVFRRCCEKTMEVMRNSQET 1596
K + E VPF LT D + MG +G + F+ C K +R+
Sbjct: 967 HILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNL 1026
Query: 1597 LLTIVEVLL 1605
L+ + ++L
Sbjct: 1027 LIILFSMML 1035
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 50.8 bits (120), Expect = 1e-05
Identities = 67/346 (19%), Positives = 136/346 (39%), Gaps = 38/346 (10%)
Query: 1375 RQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVN 1434
R++ + Q+ ++ N L++ ET KR L +VV +S + ++E ++ + E
Sbjct: 3511 RREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIY-- 3568
Query: 1435 NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQP------VFRYFCM 1488
+ K+ +D + ++ VQ + + ++V D+ + Q + + + +
Sbjct: 3569 -KQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWAL 3627
Query: 1489 EKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ 1548
F + ++ R +T +A ++L L + + + I + + +L VA+ +
Sbjct: 3628 HTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKL-----NVAYFR 3682
Query: 1549 GKI------LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVE 1602
I L VPFRLT +I + + GV G + I++
Sbjct: 3683 FDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILK 3742
Query: 1603 VLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL 1662
+L D + W ++ +++T L+A Q + + K ++
Sbjct: 3743 TVLRDEIIAW----------HKKTQEDTS--SPLSAAGQPENMDSQQLVSLVQKAVTAIM 3790
Query: 1663 MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
RL L E G +VN L+ A NL R+ P W W+
Sbjct: 3791 TRLHN-LAQFEGGE-----SKVNTLVAAANSLDNLCRMDPAWHPWL 3830
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 48.1 bits (113), Expect = 7e-05
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 53/242 (21%)
Query: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426
+VK DDLRQ+ + QV + LQ E + L I YK++ +S SG++E V
Sbjct: 574 IVKCGDDLRQELLAFQVLKQ----LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629
Query: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486
I + V+K+S + F+ ++
Sbjct: 630 SIHQ-----------------------------VKKQSQLSLLDYFLQEHGSYTT----- 655
Query: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF 1546
E FL + + +S A +V Y+L + DRH NIL++ + ++HID G
Sbjct: 656 --EAFLSA------QRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFIL 706
Query: 1547 EQGKILPTPETVPFRLTRDIVDGMGITGVEG----VFRRCCEKTMEVMRNSQETLLTIVE 1602
ET F+LT + VD MG G++G ++ + + R + ++ IVE
Sbjct: 707 SSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
Query: 1603 VL 1604
++
Sbjct: 765 IM 766
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 47.8 bits (112), Expect = 9e-05
Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 54/284 (19%)
Query: 1361 GKERRQLVKGRDDLRQDAVMQQVFQ-MCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 1419
GK + K DDLRQD ++ Q+ Q M N LQ + + + Y+ + + G++
Sbjct: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLD-----MQMIIYRCLSTGKDQGLV 967
Query: 1420 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 1479
+ V + + ++ G + N KK F + + D +
Sbjct: 968 QMVPDAVTLAK--IHRHSGLIGPLKENTI-------------KKWFSQHNHLKAD----Y 1008
Query: 1480 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 1539
+ R F F A W +V +ILG+ DRH NI++ +S + H
Sbjct: 1009 EKALRNF----FYSCAGW--------------CVVTFILGVCDRHNDNIMLT-KSGHMFH 1049
Query: 1540 IDLGVAFEQGKILP--TPETVPFRLTRDI-----VDGMGITGVEGVFRRCCEKTMEVMRN 1592
ID G + + PF T ++ G + CC + ++R
Sbjct: 1050 IDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCC-RAYNIIRK 1108
Query: 1593 SQETLLTIVEVLLYDPLFDWT-MNPLKALYLQQRPEDETELHPT 1635
+ LL ++E++LY L + + + LK +Y RP+D T+L T
Sbjct: 1109 HSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQD-TDLEAT 1151
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 3/66 (4%)
Query: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--VAFEQGKILPTPETVPFR 1561
+TRS A + +ILG+GDRH NI++ + +L HID G + ++ K E VPF
Sbjct: 897 FTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
Query: 1562 LTRDIV 1567
LT+D +
Sbjct: 956 LTQDFL 961
>gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.011
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 834 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 892
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 893 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 932
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 933 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 992
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 993 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 1051
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 1052 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 1102
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|169207756 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.011
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 834 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 892
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 893 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 932
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 933 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 992
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 993 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 1051
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 1052 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 1102
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|169207046 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.011
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 834 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 892
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 893 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 932
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 933 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 992
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 993 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 1051
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 1052 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 1102
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 40.4 bits (93), Expect = 0.015
Identities = 84/350 (24%), Positives = 142/350 (40%), Gaps = 56/350 (16%)
Query: 777 HESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL-----QAI 831
+E L + SLR R + ARVK++E+ K ES+ LS++ Q
Sbjct: 560 NEHLNQTVSSLRQRS-----QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 832 GELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEM 891
ELE E R+ +L +K ++LL Q+ I L+ + E + E
Sbjct: 615 KELEHYKEKGERA---EELENELHHLEKENELL-------QKKITNLK-ITCEKIEALEQ 663
Query: 892 DNSQRECIKDILTKHLVELSILARTFK-----NTQLPERAIFQIKQYNSVSCG---VSEW 943
+NS+ E L K L L + N+QL E + + S+ C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 944 QLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLE 1003
QLE ++ K++ L +LK KK TE L V L +E
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKK----------------TERLEVSYQGLD---IE 764
Query: 1004 NPAVIMQTYLEKAVEVAGNYDGESSD-ELRNGKMKAFLSLARFSDTQYQRIENYMKSSEF 1062
N +Q LE + + + E D E+ N ++ L + S + +++E KS E
Sbjct: 765 NQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 1063 ENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 1112
E Q K++ L +E+K + +K LE + + + L+++ K
Sbjct: 823 ETSQL----EKDKKQLEKENKRLRQQAEIK-DTTLEENNVKIGNLEKENK 867
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 40.4 bits (93), Expect = 0.015
Identities = 84/350 (24%), Positives = 142/350 (40%), Gaps = 56/350 (16%)
Query: 777 HESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL-----QAI 831
+E L + SLR R + ARVK++E+ K ES+ LS++ Q
Sbjct: 560 NEHLNQTVSSLRQRS-----QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 832 GELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEM 891
ELE E R+ +L +K ++LL Q+ I L+ + E + E
Sbjct: 615 KELEHYKEKGERA---EELENELHHLEKENELL-------QKKITNLK-ITCEKIEALEQ 663
Query: 892 DNSQRECIKDILTKHLVELSILARTFK-----NTQLPERAIFQIKQYNSVSCG---VSEW 943
+NS+ E L K L L + N+QL E + + S+ C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 944 QLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLE 1003
QLE ++ K++ L +LK KK TE L V L +E
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKK----------------TERLEVSYQGLD---IE 764
Query: 1004 NPAVIMQTYLEKAVEVAGNYDGESSD-ELRNGKMKAFLSLARFSDTQYQRIENYMKSSEF 1062
N +Q LE + + + E D E+ N ++ L + S + +++E KS E
Sbjct: 765 NQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 1063 ENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 1112
E Q K++ L +E+K + +K LE + + + L+++ K
Sbjct: 823 ETSQL----EKDKKQLEKENKRLRQQAEIK-DTTLEENNVKIGNLEKENK 867
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 38.1 bits (87), Expect = 0.074
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 1482 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 668 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 726
Query: 1541 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 1593
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 727 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 782
Query: 1594 QETLLTIVEVLL 1605
+ ++++V ++L
Sbjct: 783 MDAVVSLVTLML 794
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 38.1 bits (87), Expect = 0.074
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 1482 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 1858 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 1916
Query: 1541 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 1593
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 1917 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 1972
Query: 1594 QETLLTIVEVLL 1605
+ ++++V ++L
Sbjct: 1973 MDAVVSLVTLML 1984
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
3 alpha [Homo sapiens]
Length = 286
Score = 37.7 bits (86), Expect = 0.096
Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 1482 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 122 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 180
Query: 1541 DLGVAFE 1547
D G FE
Sbjct: 181 DFGFMFE 187
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 36.2 bits (82), Expect = 0.28
Identities = 57/290 (19%), Positives = 115/290 (39%), Gaps = 30/290 (10%)
Query: 817 SVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQK-HSQLLKDSDFSFQEPI 875
+++ +Y T S + + E + GE+F + V R+ + Q+ Q+L+ F +
Sbjct: 123 NLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDV 182
Query: 876 MALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNS 935
+ L IL+ E + I D +++ S R T PE +I Y+
Sbjct: 183 VHLDLKPQNILLTSESPLGDIK-IVDFGLSRILKNSEELREIMGT--PEYVAPEILSYDP 239
Query: 936 VSCGVSEWQL-----------------EEAQVFWAKKEQSLALS-----ILKQMIKKLDA 973
+S W + ++ + F + +L+ S +L +
Sbjct: 240 ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIR 299
Query: 974 SCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEK--AVEVAGNYDGESSDEL 1031
+ P + T ECL+ WL ++ ++ P+ M+ LE+ A++ + +SD
Sbjct: 300 TLLVKKPEDRATAEECLK--HPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTD 357
Query: 1032 RNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLRE 1081
++ ++ ++ T Y + E ++A+ KR K E LL+E
Sbjct: 358 KSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQE 407
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo sapiens]
Length = 955
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/129 (22%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 1008 IMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQA 1067
I Q Y ++ VE+ ++ E + L+ + SL R + + + +E ++++ E++
Sbjct: 653 IRQRYEQQIVELKLEHEQEKTHLLQQHNAEKD-SLVRDHEREIENLEKQLRAANMEHENQ 711
Query: 1068 LLKRAKEEVGLLRE-----HKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENY 1122
+ + K + ++ + HK++ V QR+ +L EL L L+E+ K+ + E
Sbjct: 712 IQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL--LREEEKQRATREHEIV 769
Query: 1123 INCLLSGEE 1131
+N L + E
Sbjct: 770 VNKLKAESE 778
>gi|83716024 kinesin family member 21B [Homo sapiens]
Length = 1624
Score = 35.4 bits (80), Expect = 0.48
Identities = 40/167 (23%), Positives = 81/167 (48%), Gaps = 16/167 (9%)
Query: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVI-----MQTYLE- 1014
+ I +++I +L+ S +LK Y E L + N + +T LE V+ M+ Y E
Sbjct: 643 IEIKQKLIDELENS-QRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEE 701
Query: 1015 KAVEVAGNYDGESSDELRN-----GKMKAFLSLARFSDTQYQRIENYMKSSEFENKQA-- 1067
KA ++ +Y+ + R+ K L + + ++Y+R +++ E K+A
Sbjct: 702 KANKIKADYEKRLREMNRDLQKLQAAQKEHARLLK-NQSRYERELKKLQAEVAEMKKAKV 760
Query: 1068 -LLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKR 1113
L+K+ +EE R + + NR ++++E E +RAL+ +++
Sbjct: 761 ALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQ 807
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,889,023
Number of Sequences: 37866
Number of extensions: 2607874
Number of successful extensions: 7191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 7034
Number of HSP's gapped (non-prelim): 193
length of query: 1708
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1592
effective length of database: 13,855,062
effective search space: 22057258704
effective search space used: 22057258704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.