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Search of human proteins with 20336184
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
(962 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 2050 0.0
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 2038 0.0
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 1891 0.0
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 1880 0.0
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 1294 0.0
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 1294 0.0
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 1294 0.0
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 1045 0.0
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 992 0.0
gi|4505579 furin preproprotein [Homo sapiens] 672 0.0
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 615 e-176
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 600 e-171
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 504 e-142
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 461 e-129
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 137 4e-32
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 137 4e-32
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 137 4e-32
gi|108773804 Fraser syndrome 1 [Homo sapiens] 117 7e-26
gi|18490982 R-spondin 3 [Homo sapiens] 65 4e-10
gi|54792098 erbB-2 isoform b [Homo sapiens] 64 9e-10
gi|54792096 erbB-2 isoform a [Homo sapiens] 64 9e-10
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo... 63 2e-09
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo... 63 2e-09
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 62 3e-09
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 62 3e-09
gi|29725609 epidermal growth factor receptor isoform a precursor... 61 6e-09
gi|41327736 epidermal growth factor receptor isoform d precursor... 61 6e-09
gi|41327732 epidermal growth factor receptor isoform b precursor... 61 6e-09
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 61 6e-09
gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo... 60 1e-08
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 2050 bits (5311), Expect = 0.0
Identities = 962/962 (100%), Positives = 962/962 (100%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
Query: 661 KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC 720
KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC
Sbjct: 661 KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC 720
Query: 721 PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES 780
PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES
Sbjct: 721 PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES 780
Query: 781 QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG 840
QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG
Sbjct: 781 QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG 840
Query: 841 TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPPGGERQAAVS 900
TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPPGGERQAAVS
Sbjct: 841 TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPPGGERQAAVS 900
Query: 901 SKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMHICWVPAVGRHRAA 960
SKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMHICWVPAVGRHRAA
Sbjct: 901 SKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMHICWVPAVGRHRAA 960
Query: 961 AG 962
AG
Sbjct: 961 AG 962
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 2038 bits (5281), Expect = 0.0
Identities = 961/975 (98%), Positives = 961/975 (98%), Gaps = 13/975 (1%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
Query: 661 KAALSPSQVEVPEDEEDY-------------TGVCHPECGDKGCDGPNADQCLNCVHFSL 707
KAALSPSQVEVPEDEEDY T VCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
Query: 708 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 767
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
Query: 768 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 827
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
Query: 828 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
Query: 888 YGPPGGERQAAVSSKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMH 947
YGPPGGERQAAVSSKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMH
Sbjct: 901 YGPPGGERQAAVSSKGVPGGQSLAASSPGAGEGMLHHPTVDRSPFTELLRGLRPFVHWMH 960
Query: 948 ICWVPAVGRHRAAAG 962
ICWVPAVGRHRAAAG
Sbjct: 961 ICWVPAVGRHRAAAG 975
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 1891 bits (4899), Expect = 0.0
Identities = 887/887 (100%), Positives = 887/887 (100%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
Query: 661 KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC 720
KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC
Sbjct: 661 KAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC 720
Query: 721 PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES 780
PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES
Sbjct: 721 PLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES 780
Query: 781 QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG 840
QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG
Sbjct: 781 QKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCG 840
Query: 841 TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887
TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 841 TCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887
Score = 81.6 bits (200), Expect = 3e-15
Identities = 47/140 (33%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 682 CHPECGDKGCDGPNADQCLNCVH-FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 740
CHP C K D P ++C C FSL C+ C G + D+ RC CH C
Sbjct: 787 CHPSC-KKCVDEP--EKCTVCKEGFSLAR----GSCIPDCEPGTYFDSELIRCGECHHTC 839
Query: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES----QKNCLKCHPSCKKCVD 796
TC +C+ C + F+ H CV C GFY +E K C +C +C C
Sbjct: 840 GTCVGPGREECIHCAKNFHFHDWK--CVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG 897
Query: 797 EPEKCTVCKEGFSLARGSCI 816
C+ CK GF+ SCI
Sbjct: 898 SSRNCSRCKTGFTQLGTSCI 917
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 1880 bits (4869), Expect = 0.0
Identities = 886/900 (98%), Positives = 886/900 (98%), Gaps = 13/900 (1%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
Query: 661 KAALSPSQVEVPEDEEDY-------------TGVCHPECGDKGCDGPNADQCLNCVHFSL 707
KAALSPSQVEVPEDEEDY T VCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
Query: 708 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 767
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
Query: 768 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 827
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
Query: 828 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
Score = 81.6 bits (200), Expect = 3e-15
Identities = 47/140 (33%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 682 CHPECGDKGCDGPNADQCLNCVH-FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 740
CHP C K D P ++C C FSL C+ C G + D+ RC CH C
Sbjct: 800 CHPSC-KKCVDEP--EKCTVCKEGFSLAR----GSCIPDCEPGTYFDSELIRCGECHHTC 852
Query: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES----QKNCLKCHPSCKKCVD 796
TC +C+ C + F+ H CV C GFY +E K C +C +C C
Sbjct: 853 GTCVGPGREECIHCAKNFHFHDWK--CVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG 910
Query: 797 EPEKCTVCKEGFSLARGSCI 816
C+ CK GF+ SCI
Sbjct: 911 SSRNCSRCKTGFTQLGTSCI 930
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 1294 bits (3349), Expect = 0.0
Identities = 621/622 (99%), Positives = 621/622 (99%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKL 622
QWTLEIQDLPSQVRNPEKQG L
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGNL 622
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 1294 bits (3349), Expect = 0.0
Identities = 621/623 (99%), Positives = 622/623 (99%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLK 623
QWTLEIQDLPSQVRNPEKQG L+
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGDLE 623
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 1294 bits (3349), Expect = 0.0
Identities = 621/623 (99%), Positives = 622/623 (99%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
Query: 601 QWTLEIQDLPSQVRNPEKQGKLK 623
QWTLEIQDLPSQVRNPEKQG L+
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGDLE 623
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 1045 bits (2702), Expect = 0.0
Identities = 495/856 (57%), Positives = 613/856 (71%), Gaps = 26/856 (3%)
Query: 38 GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
G G R P L +LAL C P R VYTNHWAV++ GG EA+R+A+ +G++N
Sbjct: 2 GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61
Query: 97 LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
+GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR S
Sbjct: 62 IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121
Query: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
Q+ YFNDP W +MWY+HC D C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181
Query: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241
Query: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
+RMLDGDVTD+VEAKS+ P ++ IYSASWGPDDDGKTVDGP L +QAFE G++ GR+
Sbjct: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301
Query: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
GLGS+FVWASGNGGR D+CSCDGYTNSIYTIS+SS E+G KPWYLEEC+STLATTYSS
Sbjct: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361
Query: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
G Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN LTWRDVQH++V+TSR
Sbjct: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421
Query: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I
Sbjct: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481
Query: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
+R+ S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541
Query: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN + GKLKEWSL+LYGT+
Sbjct: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601
Query: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDE---EDYTGVCHPECGDKGC 691
PY +P E PK S+VE P D+ EDY G C PEC + GC
Sbjct: 602 PY----------------SPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGC 645
Query: 692 DGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQC 751
DGP D C +C+H+ +R CVS CP G++ +RCR+C CE+C QC
Sbjct: 646 DGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQC 704
Query: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
+SC+ G++ ++E N+CVT CP G Y D + C KC +CK C E CT C++G SL
Sbjct: 705 MSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNCTECRDGLSLQ 763
Query: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
C CE G YF+ + C CH C TC G G + CI+C + + D +CV +C
Sbjct: 764 GSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSIS 821
Query: 872 FYPEEMPGLPHKVCRR 887
+Y + +K C++
Sbjct: 822 YYFDHSSENGYKSCKK 837
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 992 bits (2564), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1 MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
Query: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61 CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK 471
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK 471
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 672 bits (1733), Expect = 0.0
Identities = 363/711 (51%), Positives = 453/711 (63%), Gaps = 55/711 (7%)
Query: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
Query: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
Query: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
Query: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
Query: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
Query: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
Query: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
Query: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
Query: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
Query: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
+W FMT H W E G+W LEI++ S+ N G L +++L+LYGTA
Sbjct: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGTAPE-------- 576
Query: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCV 703
L P L+ SQ V EE ++ H + + C A Q L+
Sbjct: 577 -------GLPVPPESSGCKTLTSSQACV-VCEEGFS--LHQKSCVQHCPPGFAPQVLDTH 626
Query: 704 HFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSC 754
+ + V+T R V C CH C TC A T CLSC
Sbjct: 627 YSTENDVETIRASV---------------CAPCHASCATCQGPALTDCLSC 662
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 838
K + + C VC+EGFSL + SC+ C PG T D E IR C CH +
Sbjct: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647
Query: 839 CGTCVGPGREECIHC 853
C TC GP +C+ C
Sbjct: 648 CATCQGPALTDCLSC 662
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)
Query: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 784
GC+T +S A C+ C GF HQ+ +CV CP GF Y+ E+ C
Sbjct: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
Query: 785 LKCHPSCKKC 794
CH SC C
Sbjct: 642 APCHASCATC 651
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 615 bits (1585), Expect = e-176
Identities = 335/745 (44%), Positives = 443/745 (59%), Gaps = 80/745 (10%)
Query: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
Query: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
Query: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
Query: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
Query: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
Query: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
Query: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
Query: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
Query: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
Query: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
D+S EG+ NW FM+ H W E +G WTL +++ G L ++L+LYGTAE
Sbjct: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580
Query: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNA 696
+++A P + + Q D G+C + CDGP
Sbjct: 581 --------------DMTARPTGPQVTSSACVQ-------RDTEGLC------QACDGP-- 611
Query: 697 DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AARRCRRCHKGCETC 743
+ LG + C++ CP +F T A R C CH C TC
Sbjct: 612 -------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTC 659
Query: 744 SSRAATQCLSCRRGFYHHQEMNTCV 768
+ C SC Q+ +C+
Sbjct: 660 RGGSPRDCTSCPPSSTLDQQQGSCM 684
Score = 38.9 bits (89), Expect = 0.023
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 15/108 (13%)
Query: 740 CETCSSRA---ATQCLS-CRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC- 794
C+ C A CL+ C F++H + VT P G A + + C CH SC C
Sbjct: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRL---VTAGP-GHTAAPALRVCSSCHASCYTCR 660
Query: 795 VDEPEKCTVCKEGFSL--ARGSCIPDCEPGTYFDSELIRCGEC-HHTC 839
P CT C +L +GSC+ P T +R C HH C
Sbjct: 661 GGSPRDCTSCPPSSTLDQQQGSCM---GPTTPDSRPRLRAAACPHHRC 705
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 600 bits (1548), Expect = e-171
Identities = 305/593 (51%), Positives = 397/593 (66%), Gaps = 10/593 (1%)
Query: 51 WLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFY 110
++L A A SA R + N WA ++ GGP A +A GY LGQIG+LE++Y F
Sbjct: 13 FVLFCAWCALNSAKAKRQ-FVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFK 71
Query: 111 HSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWY 170
H +RS S+ L D +V W +QQ K R KR D FNDP+W+ WY
Sbjct: 72 HKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWY 131
Query: 171 LHCGDKNSRC-RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNG 229
L + + +++V W++G TGK VV+T+LDDG+E NH D+ NYD ASYD N
Sbjct: 132 LQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFND 191
Query: 230 NDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEA 289
ND+DP PRYD +NENKHGTRCAGE+A ANN C VG+AYN+K+GGIRMLDG VTD +EA
Sbjct: 192 NDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEA 251
Query: 290 KSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGG 349
S+G P ++DIYSASWGP+DDGKTV+GPGRLA++AFEYG+K+GRQG GSIFVWASGNGG
Sbjct: 252 SSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGG 311
Query: 350 REGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR 409
R+GD C CDGYT+SIYTIS+SSA++ G PWY E+C+STLAT+YSSG + +++I + DL
Sbjct: 312 RQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLH 371
Query: 410 QRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKAS-DWKVNGA 468
CT+ HTGTS SAP+ AGI ALALEAN LTWRD+QHL+V TS L + WK NGA
Sbjct: 372 NDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGA 431
Query: 469 GHKVSHFYGFGLVDAEALV--VEAKKWTAVPSQHMCVAA-SDKRPRSIPLVQVLRTTALT 525
G V+ +GFGL++A+ALV + + W +VP + CV +D PR++ + T
Sbjct: 432 GLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPT 491
Query: 526 SACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTN 585
AC E + + LEHV +I + RRGDL + L S +GT + LLA+R D S GF N
Sbjct: 492 RAC-EGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKN 550
Query: 586 WEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYH 638
W+FM+VH WGE G WTL I D+ +++N +G++ W LIL+GT+ P H
Sbjct: 551 WDFMSVHTWGENPIGTWTLRITDMSGRIQN---EGRIVNWKLILHGTSSQPEH 600
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 504 bits (1298), Expect = e-142
Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)
Query: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
Query: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
Query: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
Query: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
Query: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
Query: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
Query: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
Query: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
Query: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
Query: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
WGE A G WTLE+ V + ++G LKEW+L+L+GT PY +S++
Sbjct: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
Query: 654 APELE 658
ELE
Sbjct: 616 KEELE 620
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 461 bits (1186), Expect = e-129
Identities = 259/606 (42%), Positives = 349/606 (57%), Gaps = 29/606 (4%)
Query: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
Query: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
Query: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
Query: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
Query: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
Query: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
Query: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
Query: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
Query: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+ +
Sbjct: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
Query: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
+ G L++W L LYG+ + R R+LE +S L A P +++PE
Sbjct: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
Query: 674 DEEDYT 679
E+ YT
Sbjct: 655 -EDGYT 659
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 137 bits (346), Expect = 4e-32
Identities = 74/204 (36%), Positives = 92/204 (45%), Gaps = 12/204 (5%)
Query: 675 EEDYTGV--CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+ED G CH +C C GP DQC C + S+ + CV CP GY+ D + R
Sbjct: 455 DEDAPGCKPCHVKCFH--CMGPAEDQCQTC---PMNSLLLNTTCVKDCPEGYYADEDSNR 509
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C CH C TC R + QC SCR G++ Q C+ C G+YAD S C +C+ SCK
Sbjct: 510 CAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 793 KCVD-EPEKCTVCKEGFSLAR--GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE 849
C P C C F L R G C C Y + C CH TC C G G
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627
Query: 850 CIHCAKNFHFHDWKCVPACGEGFY 873
C+ C ++H C C G Y
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEY 651
Score = 131 bits (330), Expect = 3e-30
Identities = 62/201 (30%), Positives = 97/201 (48%), Gaps = 10/201 (4%)
Query: 673 EDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+++ + CH C + C+G ++ QC +C G + ++C+ C GY+ D + R
Sbjct: 504 DEDSNRCAHCHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGR 558
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C RC++ C+ C T CLSC R F+ + C CP +Y ++S + C +CHP+C
Sbjct: 559 CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 793 KCVDEPE-KCTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREE 849
+C + C C + L G C DC G Y + E C +CH +C C GPG +
Sbjct: 619 QCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKN 678
Query: 850 CIHCAKN--FHFHDWKCVPAC 868
C C N H + C+ C
Sbjct: 679 CTLCPANLVLHMDESHCLHCC 699
Score = 124 bits (312), Expect = 3e-28
Identities = 65/201 (32%), Positives = 90/201 (44%), Gaps = 10/201 (4%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH +C + C GP AD C C+ S V C+ CP G + + + CR CHK C
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKQTKECRDCHKSCL 419
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
TCSS C +C++G + +C+ C Y DE C CH C C+ E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476
Query: 800 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 858
+C C L +C+ DC G Y D + RC CH +C TC G +C C +
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536
Query: 859 FHDWKCVPACGEGFYPEEMPG 879
+C+ C EG+Y + G
Sbjct: 537 QLGKECLLQCREGYYADNSTG 557
Score = 98.6 bits (244), Expect = 2e-20
Identities = 61/224 (27%), Positives = 86/224 (38%), Gaps = 20/224 (8%)
Query: 675 EEDYTGVCHPECGDKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARR 732
E+ Y+ + D C + + C C F LG CV C G++GD
Sbjct: 66 EKTYSEAVECKACDSNCSSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGE 120
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSC 791
C CH+ CETC+ +C SC+ G + M T G + ++ + CH SC
Sbjct: 121 CESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSC 180
Query: 792 KKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECI 851
K C CT C +G L +C+ C GT+ C C C C G + C
Sbjct: 181 KTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCK 238
Query: 852 HCAKN----FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPP 891
C H+ +C C EG Y E+ +C R P
Sbjct: 239 KCQMQPGHPLFLHEGRCYSKCPEGSYAED------GICERCSSP 276
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/227 (29%), Positives = 95/227 (41%), Gaps = 18/227 (7%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH C K C+G +A C +C G+ ++ CVS CP G + + C C + C
Sbjct: 176 CHSSC--KTCNG-SATLCTSCPK---GAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNT--CVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
CS A C C+ H ++ C + CP G YA++ C +C C+ C
Sbjct: 230 ICSG--ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGI--CERCSSPCRTCEGNAT 285
Query: 800 KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHF 859
C C+ G L G C +C P + E + C C C C+ + C C F
Sbjct: 286 NCHSCEGGHVLHHGVCQENC-PERHVAVEGV-CKHCPEMCQDCIH--EKTCKECMPEFFL 341
Query: 860 HDWKCVPACGEGFYPEEMPGLP-HKVCRR-YGPPGGERQAAVSSKGV 904
HD C +C GFY + +P HK C GP + + + S V
Sbjct: 342 HDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWV 388
Score = 87.8 bits (216), Expect = 4e-17
Identities = 43/116 (37%), Positives = 53/116 (45%), Gaps = 9/116 (7%)
Query: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
L C F HH C CP Y++ + C C +C C + C C+EGF L
Sbjct: 50 LKCGNRFDHH-----CYKTCPEKTYSEAVE--CKACDSNCSSC--DQNGCYWCEEGFFLL 100
Query: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA 867
GSC+ C PG Y D E+ C CH C TC GPG +EC C + CV A
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHA 156
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 137 bits (346), Expect = 4e-32
Identities = 74/204 (36%), Positives = 92/204 (45%), Gaps = 12/204 (5%)
Query: 675 EEDYTGV--CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+ED G CH +C C GP DQC C + S+ + CV CP GY+ D + R
Sbjct: 455 DEDAPGCKPCHVKCFH--CMGPAEDQCQTC---PMNSLLLNTTCVKDCPEGYYADEDSNR 509
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C CH C TC R + QC SCR G++ Q C+ C G+YAD S C +C+ SCK
Sbjct: 510 CAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 793 KCVD-EPEKCTVCKEGFSLAR--GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE 849
C P C C F L R G C C Y + C CH TC C G G
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627
Query: 850 CIHCAKNFHFHDWKCVPACGEGFY 873
C+ C ++H C C G Y
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEY 651
Score = 133 bits (334), Expect = 9e-31
Identities = 63/201 (31%), Positives = 97/201 (48%), Gaps = 10/201 (4%)
Query: 673 EDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+++ + CH C + C+G ++ QC +C G + ++C+ C GY+ D + R
Sbjct: 504 DEDSNRCAHCHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGR 558
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C RC++ C+ C T CLSC R F+ + C CP +Y ++S + C +CHP+C
Sbjct: 559 CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 793 KCVDEPE-KCTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREE 849
+C + C C + L G C DC G Y + E C +CH +C C GPG +
Sbjct: 619 QCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKN 678
Query: 850 CIHCAKN--FHFHDWKCVPAC 868
C C N H D C+ C
Sbjct: 679 CTLCPANLVLHMDDSHCLHCC 699
Score = 124 bits (312), Expect = 3e-28
Identities = 65/201 (32%), Positives = 90/201 (44%), Gaps = 10/201 (4%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH +C + C GP AD C C+ S V C+ CP G + + + CR CHK C
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKETKECRDCHKSCL 419
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
TCSS C +C++G + +C+ C Y DE C CH C C+ E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476
Query: 800 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 858
+C C L +C+ DC G Y D + RC CH +C TC G +C C +
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536
Query: 859 FHDWKCVPACGEGFYPEEMPG 879
+C+ C EG+Y + G
Sbjct: 537 QLGKECLLQCREGYYADNSTG 557
Score = 98.2 bits (243), Expect = 3e-20
Identities = 61/224 (27%), Positives = 86/224 (38%), Gaps = 20/224 (8%)
Query: 675 EEDYTGVCHPECGDKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARR 732
E+ Y+ + D C + + C C F LG CV C G++GD
Sbjct: 66 EKTYSEAVECKACDSNCGSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGE 120
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSC 791
C CH+ CETC+ +C SC+ G + M T G + ++ + CH SC
Sbjct: 121 CESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSC 180
Query: 792 KKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECI 851
K C CT C +G L +C+ C GT+ C C C C G + C
Sbjct: 181 KTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCK 238
Query: 852 HCAKN----FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPP 891
C H+ +C C EG Y E+ +C R P
Sbjct: 239 KCQMQPGHPLFLHEGRCYSKCPEGSYAED------GICERCSSP 276
Score = 94.0 bits (232), Expect = 6e-19
Identities = 65/227 (28%), Positives = 95/227 (41%), Gaps = 18/227 (7%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH C K C+G +A C +C G+ ++ CVS CP G + + C C + C
Sbjct: 176 CHSSC--KTCNG-SATLCTSCPK---GAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNT--CVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
CS A C C+ H ++ C + CP G YA++ C +C C+ C
Sbjct: 230 ICSG--ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGI--CERCSSPCRTCEGNAT 285
Query: 800 KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHF 859
C C+ G L G C +C P + + + C C C C+ + C C F
Sbjct: 286 NCHSCEGGHVLHHGVCQENC-PERHVAVKGV-CKHCPEMCQDCIH--EKTCKECTPEFFL 341
Query: 860 HDWKCVPACGEGFYPEEMPGLP-HKVCRR-YGPPGGERQAAVSSKGV 904
HD C +C GFY + +P HK C GP + + + S V
Sbjct: 342 HDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWV 388
Score = 87.0 bits (214), Expect = 7e-17
Identities = 43/116 (37%), Positives = 53/116 (45%), Gaps = 9/116 (7%)
Query: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
L C F HH C CP Y++ + C C +C C + C C+EGF L
Sbjct: 50 LKCGNRFDHH-----CYKTCPEKTYSEAVE--CKACDSNCGSC--DQNGCYWCEEGFFLL 100
Query: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA 867
GSC+ C PG Y D E+ C CH C TC GPG +EC C + CV A
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHA 156
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 137 bits (346), Expect = 4e-32
Identities = 74/204 (36%), Positives = 92/204 (45%), Gaps = 12/204 (5%)
Query: 675 EEDYTGV--CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+ED G CH +C C GP DQC C + S+ + CV CP GY+ D + R
Sbjct: 455 DEDAPGCKPCHVKCFH--CMGPAEDQCQTC---PMNSLLLNTTCVKDCPEGYYADEDSNR 509
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C CH C TC R + QC SCR G++ Q C+ C G+YAD S C +C+ SCK
Sbjct: 510 CAHCHSSCRTCEGRHSRQCHSCRPGWF--QLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 793 KCVD-EPEKCTVCKEGFSLAR--GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE 849
C P C C F L R G C C Y + C CH TC C G G
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627
Query: 850 CIHCAKNFHFHDWKCVPACGEGFY 873
C+ C ++H C C G Y
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEY 651
Score = 133 bits (334), Expect = 9e-31
Identities = 63/201 (31%), Positives = 97/201 (48%), Gaps = 10/201 (4%)
Query: 673 EDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARR 732
+++ + CH C + C+G ++ QC +C G + ++C+ C GY+ D + R
Sbjct: 504 DEDSNRCAHCHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGR 558
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C RC++ C+ C T CLSC R F+ + C CP +Y ++S + C +CHP+C
Sbjct: 559 CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 793 KCVDEPE-KCTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREE 849
+C + C C + L G C DC G Y + E C +CH +C C GPG +
Sbjct: 619 QCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKN 678
Query: 850 CIHCAKN--FHFHDWKCVPAC 868
C C N H D C+ C
Sbjct: 679 CTLCPANLVLHMDDSHCLHCC 699
Score = 124 bits (312), Expect = 3e-28
Identities = 65/201 (32%), Positives = 90/201 (44%), Gaps = 10/201 (4%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH +C + C GP AD C C+ S V C+ CP G + + + CR CHK C
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKETKECRDCHKSCL 419
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
TCSS C +C++G + +C+ C Y DE C CH C C+ E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476
Query: 800 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 858
+C C L +C+ DC G Y D + RC CH +C TC G +C C +
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536
Query: 859 FHDWKCVPACGEGFYPEEMPG 879
+C+ C EG+Y + G
Sbjct: 537 QLGKECLLQCREGYYADNSTG 557
Score = 97.4 bits (241), Expect = 6e-20
Identities = 61/224 (27%), Positives = 86/224 (38%), Gaps = 20/224 (8%)
Query: 675 EEDYTGVCHPECGDKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARR 732
E+ Y+ + D C + + C C F LG CV C G++GD
Sbjct: 66 EKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGE 120
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSC 791
C CH+ CETC+ +C SC+ G + M T G + ++ + CH SC
Sbjct: 121 CESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSC 180
Query: 792 KKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECI 851
K C CT C +G L +C+ C GT+ C C C C G + C
Sbjct: 181 KTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCK 238
Query: 852 HCAKN----FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRYGPP 891
C H+ +C C EG Y E+ +C R P
Sbjct: 239 KCQMQPGHPLFLHEGRCYSKCPEGSYAED------GICERCSSP 276
Score = 94.0 bits (232), Expect = 6e-19
Identities = 65/227 (28%), Positives = 95/227 (41%), Gaps = 18/227 (7%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH C K C+G +A C +C G+ ++ CVS CP G + + C C + C
Sbjct: 176 CHSSC--KTCNG-SATLCTSCPK---GAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNT--CVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
CS A C C+ H ++ C + CP G YA++ C +C C+ C
Sbjct: 230 ICSG--ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGI--CERCSSPCRTCEGNAT 285
Query: 800 KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHF 859
C C+ G L G C +C P + + + C C C C+ + C C F
Sbjct: 286 NCHSCEGGHVLHHGVCQENC-PERHVAVKGV-CKHCPEMCQDCIH--EKTCKECTPEFFL 341
Query: 860 HDWKCVPACGEGFYPEEMPGLP-HKVCRR-YGPPGGERQAAVSSKGV 904
HD C +C GFY + +P HK C GP + + + S V
Sbjct: 342 HDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWV 388
Score = 89.4 bits (220), Expect = 2e-17
Identities = 44/116 (37%), Positives = 54/116 (46%), Gaps = 9/116 (7%)
Query: 752 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 811
L C F HH C CP Y++E + C C +C C + C C+EGF L
Sbjct: 50 LKCGNRFDHH-----CYKTCPEKTYSEEVE--CKACDSNCGSC--DQNGCYWCEEGFFLL 100
Query: 812 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA 867
GSC+ C PG Y D E+ C CH C TC GPG +EC C + CV A
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHA 156
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 117 bits (292), Expect = 7e-26
Identities = 75/240 (31%), Positives = 103/240 (42%), Gaps = 38/240 (15%)
Query: 680 GVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSVCPLGY 724
G C CG D+ CD GP++ +CL C +V KC+S CP GY
Sbjct: 541 GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSECPGGY 597
Query: 725 FGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNC 784
+ D A RC+ CH C +CS + C +C Q C+ C GFY+D C
Sbjct: 598 YAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDHGV--C 652
Query: 785 LKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDSELIRC 832
CH SC C+ P CT CK EG + + G C+ C Y +S I C
Sbjct: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711
Query: 833 GECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCRR-YGP 890
CH +C C G C C + D +C+ C +G++ +E H CR+ +GP
Sbjct: 712 EACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGP 771
Score = 110 bits (276), Expect = 5e-24
Identities = 69/243 (28%), Positives = 92/243 (37%), Gaps = 26/243 (10%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
C P+C L C + +CV C G++ D + C CH+ C
Sbjct: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 801
C CL+CR H C + C GFY Q C C SC C +C
Sbjct: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575
Query: 802 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 861
C E L G C+ +C PG Y+ RC CH++C +C GP C C+
Sbjct: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634
Query: 862 WKCVPACGEGFYPEE-------------MPGLPHKVCRRYGPPGGERQAAVSSKGVPGGQ 908
C+P CGEGFY + M P P G + +S G+P G+
Sbjct: 635 GHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGE 694
Query: 909 SLA 911
LA
Sbjct: 695 CLA 697
Score = 109 bits (273), Expect = 1e-23
Identities = 72/230 (31%), Positives = 89/230 (38%), Gaps = 28/230 (12%)
Query: 678 YTGVCHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCR 734
Y CH C D N CL C H+ L CV CP GY+ + A C+
Sbjct: 805 YCADCHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CK 858
Query: 735 RCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC 794
+CH C TC R C SC TC T C G Y D++ C C+ C C
Sbjct: 859 KCHSSCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC 916
Query: 795 VDEPEKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
D CT C++ L G C C P Y D C EC +C C GP + +C+
Sbjct: 917 -DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQ 975
Query: 853 CAKNFHFHDWKCVPACGEGFYPEEMPGL------------PHKVCRRYGP 890
C + D CV C FY + GL PH+ R GP
Sbjct: 976 CMDGYVLQDGACVEQCLSSFYQDS--GLCKCDSYCLQCQGPHECTRCKGP 1023
Score = 103 bits (258), Expect = 6e-22
Identities = 67/207 (32%), Positives = 83/207 (40%), Gaps = 23/207 (11%)
Query: 677 DYTG---VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRC 733
D TG VCH C C GP C C S C+ C G++ D C
Sbjct: 600 DATGRCKVCHNSCAS--CSGPTPSHCTAC---SPPKALRQGHCLPRCGEGFYSDHGV--C 652
Query: 734 RRCHKGCETCSSRAATQCLSCRR---GFYHHQEMNT------CVTLCPAGFYADESQKNC 784
+ CH C C A + C C++ G Q + C+ C A FY ES C
Sbjct: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYL-ESTGIC 711
Query: 785 LKCHPSCKKCVDE-PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCV 843
CH SC +C + P CT C L G C+ C G YF E C ECH TC C
Sbjct: 712 EACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDG-YFHQEG-SCTECHPTCRQCH 769
Query: 844 GPGREECIHCAKNFHFHDWKCVPACGE 870
GP +CI C + + C +C E
Sbjct: 770 GPLESDCISCYPHISLTNGNCRTSCRE 796
Score = 84.7 bits (208), Expect = 4e-16
Identities = 57/200 (28%), Positives = 74/200 (37%), Gaps = 15/200 (7%)
Query: 674 DEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARR 732
D+ C+ CG CD + C +C V +C C Y+ D +
Sbjct: 901 DDNHVCQPCNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNT 954
Query: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
C+ C C CS T CL C G+ CV C + FY D KC C
Sbjct: 955 CKECDWSCSACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCL 1009
Query: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
+C P +CT CK F L C+ +C G + D +C C C C R+ C
Sbjct: 1010 QC-QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHL 1066
Query: 853 CAKNFHFHDWKCVPACGEGF 872
C F CV C GF
Sbjct: 1067 CDHGFFLKSGLCVYNCVPGF 1086
Score = 68.9 bits (167), Expect = 2e-11
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)
Query: 691 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 750
C GP CL C+ G V CV C ++ D+ C+ C C C + +
Sbjct: 965 CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016
Query: 751 CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 810
C C+ F + CV C G++AD ++ C C C +C ++C +C GF L
Sbjct: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073
Query: 811 ARGSCIPDCEPGTYFDSELIRCGECHHT 838
G C+ +C PG + C HT
Sbjct: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101
Score = 67.8 bits (164), Expect = 5e-11
Identities = 37/112 (33%), Positives = 48/112 (42%), Gaps = 11/112 (9%)
Query: 771 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKEGFSLAR-GSCIPDCEPGT 823
CP G A E + C + CHP C C P+ C +C++ L + G C+ C G
Sbjct: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458
Query: 824 YFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPE 875
Y L C C C TC EC C +CVP CG+GFY +
Sbjct: 459 YQAGSL--CLACQPQCSTCT--SGLECSSCQPPLLMRHGQCVPTCGDGFYQD 506
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/106 (32%), Positives = 46/106 (43%), Gaps = 9/106 (8%)
Query: 679 TGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 738
+G+C + C GP+ +C C L +CV C GYF D A +C C +
Sbjct: 999 SGLCKCDSYCLQCQGPH--ECTRCKGPFL---LLEAQCVQECGKGYFADHAKHKCTACPQ 1053
Query: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNC 784
GC CS R +C C GF+ + CV C GF S + C
Sbjct: 1054 GCLQCSHR--DRCHLCDHGFF--LKSGLCVYNCVPGFSVHTSNETC 1095
>gi|18490982 R-spondin 3 [Homo sapiens]
Length = 272
Score = 64.7 bits (156), Expect = 4e-10
Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)
Query: 724 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 766
Y G A R RR C GC TCS CLSC+ + E +
Sbjct: 18 YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75
Query: 767 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 824
C++ CP+G+Y C KC C C ++ CT CK GF L G C+ +C G
Sbjct: 76 CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134
Query: 825 FDSELIRCGECHH 837
++ + C H
Sbjct: 135 ANNHTMECVSIVH 147
Score = 57.0 bits (136), Expect = 8e-08
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)
Query: 683 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 730
HP +GC G A + CL+C + F+L + K C+S CP GY+G
Sbjct: 34 HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92
Query: 731 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 785
+C +C C+TC ++ C C+ GFY H + C+ CP G A+ C+
Sbjct: 93 NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)
Query: 787 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 836
C C C D C CK F+L R G C+ C G Y ++ +C +C
Sbjct: 41 CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
Query: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
C TC + C C F+ H KC+ C EG
Sbjct: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 63.5 bits (153), Expect = 9e-10
Identities = 48/153 (31%), Positives = 63/153 (41%), Gaps = 36/153 (23%)
Query: 672 PEDEEDYTGV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC------PLGY 724
PEDE G+ CH C C GP QC+NC F G ++CV C P Y
Sbjct: 470 PEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRG-----QECVEECRVLQGLPREY 524
Query: 725 FGDTAARRCRRCHKGCE------TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYAD 778
AR C CH C+ TC A QC++C H+++ CV CP+G D
Sbjct: 525 VN---ARHCLPCHPECQPQNGSVTCFGPEADQCVACA----HYKDPPFCVARCPSGVKPD 577
Query: 779 ----------ESQKNCLKCHPSC-KKCVDEPEK 800
+ + C C +C CVD +K
Sbjct: 578 LSYMPIWKFPDEEGACQPCPINCTHSCVDLDDK 610
Score = 43.9 bits (102), Expect = 7e-04
Identities = 30/118 (25%), Positives = 45/118 (38%), Gaps = 13/118 (11%)
Query: 679 TGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 738
T CH +C GC GP CL C+HF+ + C CP +T +
Sbjct: 203 TDCCHEQCA-AGCTGPKHSDCLACLHFNHSGI-----CELHCPALVTYNTDTFESMPNPE 256
Query: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP---AGFYADESQKNCLKCHPSCKK 793
G T + T C Y ++ +C +CP A++ + C KC C +
Sbjct: 257 GRYTFGASCVTAC----PYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCAR 310
Score = 41.2 bits (95), Expect = 0.005
Identities = 34/114 (29%), Positives = 46/114 (40%), Gaps = 24/114 (21%)
Query: 778 DESQKNCLKCHPSCKK--CVDE-PEKCTVCKEGFSLARGS-CIPDCE-----PGTYFDSE 828
DE L CH C + C P +C C + RG C+ +C P Y ++
Sbjct: 472 DECVGEGLACHQLCARGHCWGPGPTQCVNCSQ---FLRGQECVEECRVLQGLPREYVNAR 528
Query: 829 LIRCGECHHTCG------TCVGPGREECIHCAKNFHFHDWK-CVPACGEGFYPE 875
C CH C TC GP ++C+ CA H+ D CV C G P+
Sbjct: 529 --HCLPCHPECQPQNGSVTCFGPEADQCVACA---HYKDPPFCVARCPSGVKPD 577
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 63.5 bits (153), Expect = 9e-10
Identities = 48/153 (31%), Positives = 63/153 (41%), Gaps = 36/153 (23%)
Query: 672 PEDEEDYTGV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC------PLGY 724
PEDE G+ CH C C GP QC+NC F G ++CV C P Y
Sbjct: 500 PEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRG-----QECVEECRVLQGLPREY 554
Query: 725 FGDTAARRCRRCHKGCE------TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYAD 778
AR C CH C+ TC A QC++C H+++ CV CP+G D
Sbjct: 555 VN---ARHCLPCHPECQPQNGSVTCFGPEADQCVACA----HYKDPPFCVARCPSGVKPD 607
Query: 779 ----------ESQKNCLKCHPSC-KKCVDEPEK 800
+ + C C +C CVD +K
Sbjct: 608 LSYMPIWKFPDEEGACQPCPINCTHSCVDLDDK 640
Score = 43.9 bits (102), Expect = 7e-04
Identities = 30/118 (25%), Positives = 45/118 (38%), Gaps = 13/118 (11%)
Query: 679 TGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 738
T CH +C GC GP CL C+HF+ + C CP +T +
Sbjct: 233 TDCCHEQCA-AGCTGPKHSDCLACLHFNHSGI-----CELHCPALVTYNTDTFESMPNPE 286
Query: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP---AGFYADESQKNCLKCHPSCKK 793
G T + T C Y ++ +C +CP A++ + C KC C +
Sbjct: 287 GRYTFGASCVTAC----PYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCAR 340
Score = 41.2 bits (95), Expect = 0.005
Identities = 34/114 (29%), Positives = 46/114 (40%), Gaps = 24/114 (21%)
Query: 778 DESQKNCLKCHPSCKK--CVDE-PEKCTVCKEGFSLARGS-CIPDCE-----PGTYFDSE 828
DE L CH C + C P +C C + RG C+ +C P Y ++
Sbjct: 502 DECVGEGLACHQLCARGHCWGPGPTQCVNCSQ---FLRGQECVEECRVLQGLPREYVNAR 558
Query: 829 LIRCGECHHTCG------TCVGPGREECIHCAKNFHFHDWK-CVPACGEGFYPE 875
C CH C TC GP ++C+ CA H+ D CV C G P+
Sbjct: 559 --HCLPCHPECQPQNGSVTCFGPEADQCVACA---HYKDPPFCVARCPSGVKPD 607
>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
sapiens]
Length = 870
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/200 (27%), Positives = 71/200 (35%), Gaps = 36/200 (18%)
Query: 678 YTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCH 737
+ G CHP G C+ + C CP G++G RRC +C
Sbjct: 247 FRGRCHPVDGTCACEPGYR----------------GKYCREPCPAGFYGLGCRRRCGQC- 289
Query: 738 KGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDE 797
KG + C+ A +CL+C G+ C C GFY + C C C
Sbjct: 290 KGQQPCTV-AEGRCLTCEPGW----NGTKCDQPCATGFYGEGCSHRCPPCRDG-HACNHV 343
Query: 798 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-----GECHHTCGTCV---GPGREE 849
KCT C G+ R C C GTY + C G C G C+ G
Sbjct: 344 TGKCTRCNAGWIGDR--CETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPH 401
Query: 850 C-IHCAKNFHFHDWKCVPAC 868
C + C H D C AC
Sbjct: 402 CNVTCPPGLHGAD--CAQAC 419
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/169 (24%), Positives = 62/169 (36%), Gaps = 25/169 (14%)
Query: 682 CHPECGDKGCDGPNA-----DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRC 736
C CG C G +CL C G+ KC C G++G+ + RC C
Sbjct: 282 CRRRCGQ--CKGQQPCTVAEGRCLTCEPGWNGT-----KCDQPCATGFYGEGCSHRCPPC 334
Query: 737 HKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVD 796
G C + +C C G+ + C T C G Y ++ C C C
Sbjct: 335 RDG-HAC-NHVTGKCTRCNAGWIG----DRCETKCSNGTYGEDCAFVCADC--GSGHCDF 386
Query: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHH-TCGTCVG 844
+ +C +C G + C C PG + ++ + CH TC G
Sbjct: 387 QSGRC-LCSPG--VHGPHCNVTCPPGLH-GADCAQACSCHEDTCDPVTG 431
>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
sapiens]
Length = 865
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/200 (27%), Positives = 71/200 (35%), Gaps = 36/200 (18%)
Query: 678 YTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCH 737
+ G CHP G C+ + C CP G++G RRC +C
Sbjct: 247 FRGRCHPVDGTCACEPGYR----------------GKYCREPCPAGFYGLGCRRRCGQC- 289
Query: 738 KGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDE 797
KG + C+ A +CL+C G+ C C GFY + C C C
Sbjct: 290 KGQQPCTV-AEGRCLTCEPGW----NGTKCDQPCATGFYGEGCSHRCPPCRDG-HACNHV 343
Query: 798 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-----GECHHTCGTCV---GPGREE 849
KCT C G+ R C C GTY + C G C G C+ G
Sbjct: 344 TGKCTRCNAGWIGDR--CETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPH 401
Query: 850 C-IHCAKNFHFHDWKCVPAC 868
C + C H D C AC
Sbjct: 402 CNVTCPPGLHGAD--CAQAC 419
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/169 (24%), Positives = 62/169 (36%), Gaps = 25/169 (14%)
Query: 682 CHPECGDKGCDGPNA-----DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRC 736
C CG C G +CL C G+ KC C G++G+ + RC C
Sbjct: 282 CRRRCGQ--CKGQQPCTVAEGRCLTCEPGWNGT-----KCDQPCATGFYGEGCSHRCPPC 334
Query: 737 HKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVD 796
G C + +C C G+ + C T C G Y ++ C C C
Sbjct: 335 RDG-HAC-NHVTGKCTRCNAGWIG----DRCETKCSNGTYGEDCAFVCADC--GSGHCDF 386
Query: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHH-TCGTCVG 844
+ +C +C G + C C PG + ++ + CH TC G
Sbjct: 387 QSGRC-LCSPG--VHGPHCNVTCPPGLH-GADCAQACSCHEDTCDPVTG 431
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 31/138 (22%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD-----------TA 729
VC+ C GC GP DQCL+C FS G R C+ C L Y G+
Sbjct: 502 VCNHLCSSDGCWGPGPDQCLSCRRFSRG-----RICIESCNL-YDGEFREFENGSICVEC 555
Query: 730 ARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF---------YADES 780
+C + G TC C C H ++ CV CP G YAD
Sbjct: 556 DPQCEKMEDGLLTCHGPGPDNCTKCS----HFKDGPNCVEKCPDGLQGANSFIFKYAD-P 610
Query: 781 QKNCLKCHPSCKKCVDEP 798
+ C CHP+C + + P
Sbjct: 611 DRECHPCHPNCTQGCNGP 628
Score = 39.7 bits (91), Expect = 0.014
Identities = 30/117 (25%), Positives = 43/117 (36%), Gaps = 13/117 (11%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH EC GC GP C C++F+ S CV+ CP + + +
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNFN-----DSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ--KNCLKCHPSCKKCVD 796
T + + C F + ++CV CP+ E K C C C K D
Sbjct: 284 TYGAFCVKK---CPHNFV--VDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACD 335
Score = 36.6 bits (83), Expect = 0.12
Identities = 29/88 (32%), Positives = 36/88 (40%), Gaps = 22/88 (25%)
Query: 798 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR------CGECHHTCG-------TCVG 844
P++C C+ FS R CI C +D E C EC C TC G
Sbjct: 517 PDQCLSCRR-FSRGR-ICIESCN---LYDGEFREFENGSICVECDPQCEKMEDGLLTCHG 571
Query: 845 PGREECIHCAKNFHFHDW-KCVPACGEG 871
PG + C C+ HF D CV C +G
Sbjct: 572 PGPDNCTKCS---HFKDGPNCVEKCPDG 596
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 31/138 (22%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD-----------TA 729
VC+ C GC GP DQCL+C FS G R C+ C L Y G+
Sbjct: 502 VCNHLCSSDGCWGPGPDQCLSCRRFSRG-----RICIESCNL-YDGEFREFENGSICVEC 555
Query: 730 ARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF---------YADES 780
+C + G TC C C H ++ CV CP G YAD
Sbjct: 556 DPQCEKMEDGLLTCHGPGPDNCTKCS----HFKDGPNCVEKCPDGLQGANSFIFKYAD-P 610
Query: 781 QKNCLKCHPSCKKCVDEP 798
+ C CHP+C + + P
Sbjct: 611 DRECHPCHPNCTQGCNGP 628
Score = 39.7 bits (91), Expect = 0.014
Identities = 30/117 (25%), Positives = 43/117 (36%), Gaps = 13/117 (11%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
CH EC GC GP C C++F+ S CV+ CP + + +
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNFN-----DSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283
Query: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ--KNCLKCHPSCKKCVD 796
T + + C F + ++CV CP+ E K C C C K D
Sbjct: 284 TYGAFCVKK---CPHNFV--VDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACD 335
Score = 36.6 bits (83), Expect = 0.12
Identities = 29/88 (32%), Positives = 36/88 (40%), Gaps = 22/88 (25%)
Query: 798 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR------CGECHHTCG-------TCVG 844
P++C C+ FS R CI C +D E C EC C TC G
Sbjct: 517 PDQCLSCRR-FSRGR-ICIESCN---LYDGEFREFENGSICVECDPQCEKMEDGLLTCHG 571
Query: 845 PGREECIHCAKNFHFHDW-KCVPACGEG 871
PG + C C+ HF D CV C +G
Sbjct: 572 PGPDNCTKCS---HFKDGPNCVEKCPDG 596
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 60.8 bits (146), Expect = 6e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 736
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
Query: 737 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 780
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
Query: 781 QKNCLKCHPSC 791
C CHP+C
Sbjct: 615 HV-CHLCHPNC 624
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 24/105 (22%)
Query: 787 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 837
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
Query: 838 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPE 875
C TC G G + CI CA H+ D CV C G E
Sbjct: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGE 602
Score = 39.7 bits (91), Expect = 0.014
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
CH +C GC GP CL C F + C C PL + T +
Sbjct: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
Query: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
Score = 36.2 bits (82), Expect = 0.15
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
C P C + C G + C L + +++C C D CH C
Sbjct: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
Query: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
Query: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
Score = 30.4 bits (67), Expect = 8.3
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
+C KC PSC C + +K T +C + S RG DC
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
Query: 834 ECHHTCGT-CVGPGREECIHCAK 855
CH+ C C GP +C+ C K
Sbjct: 232 -CHNQCAAGCTGPRESDCLVCRK 253
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 60.8 bits (146), Expect = 6e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 736
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
Query: 737 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 780
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
Query: 781 QKNCLKCHPSC 791
C CHP+C
Sbjct: 615 HV-CHLCHPNC 624
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 24/105 (22%)
Query: 787 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 837
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
Query: 838 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPE 875
C TC G G + CI CA H+ D CV C G E
Sbjct: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGE 602
Score = 39.7 bits (91), Expect = 0.014
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
CH +C GC GP CL C F + C C PL + T +
Sbjct: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
Query: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
Score = 36.2 bits (82), Expect = 0.15
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
C P C + C G + C L + +++C C D CH C
Sbjct: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
Query: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
Query: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
Score = 30.4 bits (67), Expect = 8.3
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
+C KC PSC C + +K T +C + S RG DC
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
Query: 834 ECHHTCGT-CVGPGREECIHCAK 855
CH+ C C GP +C+ C K
Sbjct: 232 -CHNQCAAGCTGPRESDCLVCRK 253
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 60.8 bits (146), Expect = 6e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 736
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
Query: 737 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 780
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
Query: 781 QKNCLKCHPSC 791
C CHP+C
Sbjct: 615 HV-CHLCHPNC 624
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 24/105 (22%)
Query: 787 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 837
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
Query: 838 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPE 875
C TC G G + CI CA H+ D CV C G E
Sbjct: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGE 602
Score = 39.7 bits (91), Expect = 0.014
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
CH +C GC GP CL C F + C C PL + T +
Sbjct: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
Query: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
Score = 36.2 bits (82), Expect = 0.15
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
C P C + C G + C L + +++C C D CH C
Sbjct: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
Query: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
Query: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
Score = 30.4 bits (67), Expect = 8.3
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
+C KC PSC C + +K T +C + S RG DC
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
Query: 834 ECHHTCGT-CVGPGREECIHCAK 855
CH+ C C GP +C+ C K
Sbjct: 232 -CHNQCAAGCTGPRESDCLVCRK 253
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 60.8 bits (146), Expect = 6e-09
Identities = 41/136 (30%), Positives = 56/136 (41%), Gaps = 26/136 (19%)
Query: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPL--GYFGDTA-ARRCRRCH 737
VC P C GC GP QCL+C ++S G V CV+ C G + A C CH
Sbjct: 499 VCDPLCSSGGCWGPGPGQCLSCRNYSRGGV-----CVTHCNFLNGEPREFAHEAECFSCH 553
Query: 738 KGCE------TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAG--------FYADESQKN 783
C+ TC+ + C C H ++ CV+ CP G + + Q
Sbjct: 554 PECQPMEGTATCNGSGSDTCAQCA----HFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNE 609
Query: 784 CLKCHPSCKKCVDEPE 799
C CH +C + PE
Sbjct: 610 CRPCHENCTQGCKGPE 625
Score = 38.5 bits (88), Expect = 0.031
Identities = 40/144 (27%), Positives = 49/144 (34%), Gaps = 43/144 (29%)
Query: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC--PLGYFGDTAARRCRRCHKG 739
CH EC GC GP C C HF+ S CV C PL Y +K
Sbjct: 227 CHDECAG-GCSGPQDTDCFACRHFN-----DSGACVPRCPQPLVY------------NKL 268
Query: 740 CETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 799
T+ +Q CV CP F D Q +C++ P P+
Sbjct: 269 TFQLEPNPHTK----------YQYGGVCVASCPHNFVVD--QTSCVRACP--------PD 308
Query: 800 KCTVCKEGFSLAR---GSCIPDCE 820
K V K G + G C CE
Sbjct: 309 KMEVDKNGLKMCEPCGGLCPKACE 332
Score = 36.2 bits (82), Expect = 0.15
Identities = 39/137 (28%), Positives = 52/137 (37%), Gaps = 32/137 (23%)
Query: 759 YHHQEMNTCVTLCPAGFYAD----ESQKNCLK----CHPSCKK--CVDE-PEKCTVCKEG 807
YHH T V P D +++C+ C P C C P +C C+
Sbjct: 464 YHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCR-- 521
Query: 808 FSLARGS-CIPDC-----EPGTYFDSELIRCGECHHTC------GTCVGPGREECIHCAK 855
+ +RG C+ C EP + + C CH C TC G G + C CA
Sbjct: 522 -NYSRGGVCVTHCNFLNGEPREF--AHEAECFSCHPECQPMEGTATCNGSGSDTCAQCA- 577
Query: 856 NFHFHDW-KCVPACGEG 871
HF D CV +C G
Sbjct: 578 --HFRDGPHCVSSCPHG 592
Score = 32.7 bits (73), Expect = 1.7
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 13/56 (23%)
Query: 832 CGECHHTC-GTCVGPGREECIHCAKNFHFHDWKCVPAC-GEGFYPEEMPGLPHKVC 885
C CH C G C GPG E+C K C P C G F P P++ C
Sbjct: 183 CPPCHEVCKGRCWGPGSEDCQTLTKTI------CAPQCNGHCFGPN-----PNQCC 227
>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
sapiens]
Length = 234
Score = 60.1 bits (144), Expect = 1e-08
Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)
Query: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 796
GC TC R R G ++ C+ CP G++ Q+ C KC +C+ C
Sbjct: 46 GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
Query: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-GECHHTCGTCVGP--GREECIHC 853
+ + C CK F L +G C+P C PGT C GEC +GP G C H
Sbjct: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE------LGPWGGWSPCTHN 153
Query: 854 AK 855
K
Sbjct: 154 GK 155
Score = 54.7 bits (130), Expect = 4e-07
Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 6/72 (8%)
Query: 715 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 772
KC+ CP GYFG RC++C CE+C S+ C+ C+R FY ++ C+ CP
Sbjct: 68 KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCP 123
Query: 773 AGFYADESQKNC 784
G A ++ + C
Sbjct: 124 PGTLAHQNTREC 135
Score = 54.3 bits (129), Expect = 5e-07
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 16/95 (16%)
Query: 790 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 836
+C C+ E C+ C++ L G C+ DC PG YF E+ RC +C
Sbjct: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
Query: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
TC +C ++ CI C + F+ + KC+P C G
Sbjct: 93 ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG 125
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,578,594
Number of Sequences: 37866
Number of extensions: 2630336
Number of successful extensions: 25839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 405
Number of HSP's that attempted gapping in prelim test: 20178
Number of HSP's gapped (non-prelim): 4664
length of query: 962
length of database: 18,247,518
effective HSP length: 112
effective length of query: 850
effective length of database: 14,006,526
effective search space: 11905547100
effective search space used: 11905547100
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.