Search of human proteins with 197927168

Search of human proteins with 197927168

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197927168 leucine rich repeat transmembrane neuronal 4
isoform a [Homo sapiens]
         (590 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...  1201   0.0  
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...  1049   0.0  
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...   705   0.0  
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s...   476   e-134
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   424   e-118
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   140   4e-33
gi|198041768 synleurin [Homo sapiens]                                 135   1e-31
gi|194440719 chondroadherin-like [Homo sapiens]                       130   3e-30
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               129   1e-29
gi|225579152 insulin-like growth factor binding protein, acid la...   125   8e-29
gi|4826772 insulin-like growth factor binding protein, acid labi...   125   8e-29
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   125   1e-28
gi|51317373 netrin-G1 ligand [Homo sapiens]                           123   4e-28
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   122   1e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   122   1e-27
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            119   6e-27
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...   119   1e-26
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...   119   1e-26
gi|153251229 chondroadherin precursor [Homo sapiens]                  118   1e-26
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         118   2e-26
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   115   1e-25
gi|12007646 nyctalopin precursor [Homo sapiens]                       114   3e-25
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   114   3e-25
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...   114   3e-25
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...   113   4e-25
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           112   7e-25
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]        109   6e-24
gi|4502403 biglycan preproprotein [Homo sapiens]                      109   8e-24
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                109   8e-24
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   108   1e-23

>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score = 1201 bits (3107), Expect = 0.0
 Identities = 590/590 (100%), Positives = 590/590 (100%)

Query: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
           MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS
Sbjct: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK
Sbjct: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
           RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300

Query: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
           ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360

Query: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV 420
           SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV
Sbjct: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV 420

Query: 421 SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP 480
           SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP
Sbjct: 421 SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP 480

Query: 481 LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQA 540
           LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQA
Sbjct: 481 LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQA 540

Query: 541 HQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN 590
           HQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN
Sbjct: 541 HQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN 590


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score = 1049 bits (2712), Expect = 0.0
 Identities = 517/518 (99%), Positives = 518/518 (100%)

Query: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
           MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS
Sbjct: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK
Sbjct: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
           RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300

Query: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
           ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360

Query: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV 420
           SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV
Sbjct: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV 420

Query: 421 SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP 480
           SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP
Sbjct: 421 SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP 480

Query: 481 LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEM 518
           LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECE+
Sbjct: 481 LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEV 518


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score =  705 bits (1819), Expect = 0.0
 Identities = 354/583 (60%), Positives = 437/583 (74%), Gaps = 17/583 (2%)

Query: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
           MGF++I  L G +V LV+ PT+LL ML+ A+R CPK CRC+GK+VYCES    +IP +IS
Sbjct: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
            G  GLSLR+NS+QKLK NQF GLNQL WLYLDHN+IS++DE+AF GIRRLKELILSSN+
Sbjct: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           I+Y  N TF PV NLRNLDLSYN+L +L SEQF+GLRKL+ LHLRSNSL+T+P+R+FQDC
Sbjct: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
           RNL+ LDLGYNR+RSL+RN FAG+++LKELHLEHNQFSK+N A FPRL +L+++YLQWN+
Sbjct: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIE-PGTFKCLPNLQKLNLDSNKLTNISQETVNA 299
           I  I Q ++WTWSSL  LDLSGN+I+    P  F+C+PNLQ+LNLDSNKLT I QE +++
Sbjct: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300

Query: 300 WISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
           WISL  I+L+GN+WECSR+IC L  WLK+FKG +E+T+ICA PK +QG  V DAV+ Y+I
Sbjct: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360

Query: 360 CSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSP---GFQIPGAE-- 414
           C +     TER  L          +P+PT FKP + +   E+  P P   G   PG E  
Sbjct: 361 CGK---STTERFDLA-------RALPKPT-FKPKLPRPKHESKPPLPPTVGATEPGPETD 409

Query: 415 QEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESE 474
            + EH+SFHKIIAGSVALFLSV +ILLVIYVSWKRYPASMKQLQQ SLM+R RKK R+S 
Sbjct: 410 ADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSL 469

Query: 475 RQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPV 534
           +QM    QE+YVDYKPTN+ET ++ +NG+GPCTY  SGSRECE+P  M    + +YDQP 
Sbjct: 470 KQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPT 529

Query: 535 IGYCQAHQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIAR 577
           I YC  H  L   K +ET + E      LE   D S I T  R
Sbjct: 530 ISYCGVHHELLSHKSFETNAQEDTMETHLETELDLSTITTAGR 572


>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
           sapiens]
          Length = 522

 Score =  476 bits (1226), Expect = e-134
 Identities = 244/527 (46%), Positives = 344/527 (65%), Gaps = 19/527 (3%)

Query: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
           +G  L   L+  S V++ L      ML  A   CP+ CRC+G+++YCE+    + P N+S
Sbjct: 6   LGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS 65

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           G   GLSLR+NS+ +L++ QF GL QL WLYLDHN+I SV  DAFQ +RR+KEL LSSN+
Sbjct: 66  G-LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           IT L N TF P+PNLR++DLSYNKLQ L  + F GLRKL  LH+R+N+++ VP+R+FQDC
Sbjct: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
           R+L FLD+GYN+L+SL+RN+FAGL KL ELHLEHN   K+NFAHFPRL +L S+ L+ N+
Sbjct: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           +  +   L W W +L  +DLSGN+I+ +EP  F+ +P+LQ L LDSN+LT I    +N+W
Sbjct: 245 VAIVVSSLDWVW-NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303

Query: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
            SL SITL+GN+W+C R++C L  WL NF+G  +  + CA P++ QGE V DAV  +++C
Sbjct: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363

Query: 361 SE--------VQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPG 412
            +        +    T RS L P       +              TFE  + +    +PG
Sbjct: 364 EDGAEPTSGHLLSAVTNRSDLGPPASSATTLADG----GEGQHDGTFEPATVA----LPG 415

Query: 413 AEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARE 472
            E     V  HK++ G++AL  S  +++LV+YVSWK +PAS++QL+Q  + +RR++K ++
Sbjct: 416 GEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQ 475

Query: 473 SERQMNS-PLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEM 518
           +  QM +   QEYYVDYKP + E   + +N  G CT     +RECE+
Sbjct: 476 TMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  424 bits (1090), Expect = e-118
 Identities = 226/522 (43%), Positives = 329/522 (63%), Gaps = 10/522 (1%)

Query: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
           MG H    L    +  +   +++L ML     ACP  CRC+  + YC+S  F  +P    
Sbjct: 1   MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
            GS GLSLR N I +L+ +QFA  +QL WL+LDHN IS+V EDAFQG+ +LKELILSSNK
Sbjct: 61  KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           I YL N TF  + NL+NLDLS+N+L +L  E F GLRKL  LHLRSNSL+T+P+R+F DC
Sbjct: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
           R+L+FLDL  NRLRSL+RN FAGL+KL+ELHLEHNQ +KINFAHF RL +L +++LQWN+
Sbjct: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           I +++ G+ WTW +L  LDL+GN+I+ I+   F+ +PNL+ L +D+NKL ++  + +N+ 
Sbjct: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300

Query: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
            SL ++ LSGN+WECS  IC L  WL +F+G  E +++C  P H QGE + DAV  + +C
Sbjct: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360

Query: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQ--EYE 418
             +    T    ++  T + P       I          E P+ + G  +   E   E +
Sbjct: 361 WNLSTTVT----VMATTYRDPTTEYTKRISSSSYHVGDKEIPT-TAGIAVTTEEHFPEPD 415

Query: 419 HVSF-HKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQM 477
           +  F  ++I G++AL  S   I+ ++++S K  P ++++++Q S+++  R+   ++   M
Sbjct: 416 NAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHM 475

Query: 478 -NSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEM 518
            N   Q  Y +Y+PT+ E   I +NG G C       +ECE+
Sbjct: 476 SNMSDQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  140 bits (352), Expect = 4e-33
 Identities = 91/298 (30%), Positives = 143/298 (47%), Gaps = 1/298 (0%)

Query: 64  QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITY 123
           + L L+ N +Q L    F  L  L  L L  N ++ + E+ F  +  L+ L LS+N ++ 
Sbjct: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207

Query: 124 LHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNL 183
           L    F  + +L+ L L  N +  L  + F  L  L  L L+ N++  +P+ +F    NL
Sbjct: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267

Query: 184 DFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 243
            FL L +N LR L    FA    L  L L HNQ   +    F  L NLRS+ L +N I  
Sbjct: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327

Query: 244 ISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303
           +  G+      L  L L  N++  + P  F+ L  L+ L+L  N+LT + +   +   +L
Sbjct: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387

Query: 304 ISITLSGNMWECSRSICPLFYWLKNFKGNKESTM-ICAGPKHIQGEKVSDAVETYNIC 360
            ++ L GN W+C   +  LF WL+ +     +    CAGP +++G+ V    E   +C
Sbjct: 388 FNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 73/243 (30%), Positives = 108/243 (44%), Gaps = 18/243 (7%)

Query: 3   FHLITQLKGMSV---VLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENI 59
           F  +T LK +++   +L  LP  L   LT  Q     N            +A + +P+ +
Sbjct: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSN------------NALSGLPQGV 212

Query: 60  SG--GS-QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELIL 116
            G  GS Q L L  N+I +L    F+ L  L  L+L  N I+ +    F  +  L  L L
Sbjct: 213 FGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSL 272

Query: 117 SSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRV 176
             N +  L    F   P L  L L++N+L+T+    F  L  L  L L  N++  +P  +
Sbjct: 273 QWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGI 332

Query: 177 FQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYL 236
           F+D   L  L LG N L +L    F  L KL+ L L  NQ + +    F   +NL ++ L
Sbjct: 333 FRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL 392

Query: 237 QWN 239
             N
Sbjct: 393 HGN 395


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  135 bits (340), Expect = 1e-31
 Identities = 109/415 (26%), Positives = 186/415 (44%), Gaps = 57/415 (13%)

Query: 15  VLVLLPTLLLVMLTGAQRACPKNCR-CDGKIVYCESHAFADIPENISGGSQGLSLRFNSI 73
           + +++   LL++L      C   C+ C G+ + C +   + IP+N    +  L L  N+I
Sbjct: 13  LFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNI 72

Query: 74  QKLKSNQFAGLNQLIWLYL------------------------DHNYISSVDEDAFQGIR 109
             +  ++  GL+ L+ LYL                        ++N+I  +D   F+G+ 
Sbjct: 73  SYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLL 132

Query: 110 RLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169
            L+ L L  N+++++    F+ + +++ L+L  N+L  L S  F G+  L IL L +N++
Sbjct: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192

Query: 170 KTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLF 229
             +    FQ   NL  L LG N L  +  NAF  L  L+ L L HN    I    F  L 
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA 252

Query: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289
           NL  + L+ +RIR++++      ++L +L LS ND++ +   TF  L NL  L LD N++
Sbjct: 253 NLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRI 312

Query: 290 TNISQET-------------------------VNAWISLISITLSGNMWECSRSICPLFY 324
            +I  +T                         +    SLI +  + N WEC+  +  L  
Sbjct: 313 ISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRD 372

Query: 325 WLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSEV-QVVNTERSHLVPQTP 378
           WL +        + C  P  ++G     A+   NI + V   +N  R+  V ++P
Sbjct: 373 WLAS--SAITLNIYCQNPPSMRGR----ALRYINITNCVTSSINVSRAWAVVKSP 421


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  130 bits (328), Expect = 3e-30
 Identities = 103/351 (29%), Positives = 163/351 (46%), Gaps = 11/351 (3%)

Query: 15  VLVLLPTLLLVMLTGAQRA----CPKNCRCDG--KIVYCESHAFADIPENISGGSQGLSL 68
           V ++LP L+L++L  A++A    CP+ C CD   + V C      ++P+ I   +Q L L
Sbjct: 10  VPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDL 69

Query: 69  RFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKT 128
           + N ++ + +  F G+  L  L L H  +  V E AF+G+ RL  L L+SN +  L  + 
Sbjct: 70  QGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEA 129

Query: 129 FHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDL 188
              + +LR L+L  N L+ L+   F  L  L  L+L  N+L  +P   FQ    + +L L
Sbjct: 130 LDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRL 189

Query: 189 GYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGL 248
            +N L  L+  A AGL  L+ L L HN+   +      +   L  + L  N +    +  
Sbjct: 190 SHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEED 249

Query: 249 TWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITL 308
                 L  L L G  +Q + P  F   P L  L+L  N+L  +    +     L  + L
Sbjct: 250 GLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRL 307

Query: 309 SGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
            GN   C     PL  WL   +    S   C GP+ ++GE + DA+  +++
Sbjct: 308 QGNPLWCGCQARPLLEWLA--RARVRSDGACQGPRRLRGEAL-DALRPWDL 355



 Score =  121 bits (304), Expect = 2e-27
 Identities = 96/339 (28%), Positives = 149/339 (43%), Gaps = 11/339 (3%)

Query: 29  GAQRA---CPKNCRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAG 83
           G +RA   CP+ C C  + +   CE      +P      +Q L LR N    +    F G
Sbjct: 388 GEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPG 447

Query: 84  LNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYN 143
           L  L+ L+L H  I+ ++  A  G+ RL  L LS N++  L        P L  L L  N
Sbjct: 448 LGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERN 507

Query: 144 KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAG 203
           +   +     + L  L  LHL+ N++  +        R L ++ L  NR+  +S  A   
Sbjct: 508 RFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGP 567

Query: 204 LLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG-LTWTWSSLHNLDLSG 262
             +L++LHL+ NQ  ++       L  L  + L  N +R++  G       SL +L L+ 
Sbjct: 568 ARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNS 627

Query: 263 NDIQGIEPGTFKCL-PNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICP 321
           + ++ I PG F  L P LQ L+L  N+L  +      + + LI   LS N + C   + P
Sbjct: 628 SGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELID--LSSNPFHCDCQLLP 685

Query: 322 LFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
           L  WL     N      CA P + +G++V  A   +  C
Sbjct: 686 LHRWLTGL--NLRVGATCATPPNARGQRVKAAAAVFEDC 722


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  129 bits (323), Expect = 1e-29
 Identities = 113/397 (28%), Positives = 173/397 (43%), Gaps = 60/397 (15%)

Query: 10  KGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDG-KIVYCESHAFADIPENISGGSQG--- 65
           + + ++LV+   L L  L  A+  CP+ C C   + + C +     +P+  S  S     
Sbjct: 5   RALRLLLVVCGCLALPPL--AEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVL 62

Query: 66  -LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYL 124
             SL  N I  + +  F  L QL  L L +N I S+    F+ + RL+EL L +N +  L
Sbjct: 63  TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122

Query: 125 HNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
              T  P+  LR L  + N++  L    F+GL  L+ L L  N+L  +P  VF    NL 
Sbjct: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182

Query: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ---------------------FSKINFA 223
           +L L  NR+R L +NAFA L KL+ L+L  N+                      S  N  
Sbjct: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQ 242

Query: 224 HF-PRLFN----------------------------LRSIYLQWNRIRSISQGLTWTWSS 254
           H  PR+F                             LR + L+ NR+  +   L     S
Sbjct: 243 HLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHS 302

Query: 255 LHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWE 314
           L  LDLSGN++  + P TF  L  L++L+L +N L+ +S +   A  +L  + L GN W 
Sbjct: 303 LEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362

Query: 315 CSRSICPLFYWLKNFKGNKESTMI---CAGPKHIQGE 348
           C   +  L  W+ ++        +   C  P  ++G+
Sbjct: 363 CDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGK 399


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  125 bits (315), Expect = 8e-29
 Identities = 89/270 (32%), Positives = 129/270 (47%), Gaps = 6/270 (2%)

Query: 33  ACPKNCRC------DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQ 86
           ACP  C C      D   V+C S     +P+ + GG+Q L L  N++  +    F  L+ 
Sbjct: 78  ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 137

Query: 87  LIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQ 146
           L +L L    + S++  A  G+  L  L L  N++  L   TF   P L +L LS N+L 
Sbjct: 138 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 197

Query: 147 TLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLK 206
            L+   F+GL  L  L+L  NSL  +P   F+   +L  L L  NRL  L    F+GL +
Sbjct: 198 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 257

Query: 207 LKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ 266
           L+EL L  N    I    F +L  L+ +YL  N I +++ G      +L  LDLS N + 
Sbjct: 258 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA 317

Query: 267 GIEPGTFKCLPNLQKLNLDSNKLTNISQET 296
           G+   TF  L  L+ L L  N + ++   T
Sbjct: 318 GLLEDTFPGLLGLRVLRLSHNAIASLRPRT 347



 Score =  124 bits (311), Expect = 2e-28
 Identities = 80/246 (32%), Positives = 124/246 (50%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
           L L  N + +L+   F GL  L  L L  N ++ + + AF+G+  L+EL+L+ N++ YL 
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248

Query: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
              F  +  LR LDLS N L+ +++  F  L +L  L+L  N +  V    F   + L +
Sbjct: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308

Query: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSIS 245
           LDL +NR+  L  + F GLL L+ L L HN  + +    F  L  L  + L  NRIR ++
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368

Query: 246 QGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLIS 305
           +        L  L L  N +Q ++ G F  L N+  +NL  N L N+ ++       L S
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 428

Query: 306 ITLSGN 311
           + L G+
Sbjct: 429 LHLEGS 434



 Score =  123 bits (308), Expect = 5e-28
 Identities = 80/251 (31%), Positives = 133/251 (52%)

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           G  + L L  N +  L+   F+GL +L  L L  N + ++  + F  + RL++L L  N 
Sbjct: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 291

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           I  +    F  +  LR LDLS+N++  L  + F GL  L +L L  N++ ++  R F+D 
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
             L+ L LG+NR+R L+  +F GL +L+ L L+HNQ  ++    F  L N+  + L  N 
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           +R++ + +      LH+L L G+ +  I P TF  L  L++L L  N L  I ++++   
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471

Query: 301 ISLISITLSGN 311
             L+ + L+ N
Sbjct: 472 AELLELDLTSN 482



 Score =  119 bits (297), Expect = 1e-26
 Identities = 81/251 (32%), Positives = 120/251 (47%)

Query: 64  QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITY 123
           Q L L  N I  +    F GL  L WL L HN ++ + ED F G+  L+ L LS N I  
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 342

Query: 124 LHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNL 183
           L  +TF  +  L  L L +N+++ L    F+GL +L +L L  N L+ V    F    N+
Sbjct: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 402

Query: 184 DFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 243
             ++L  N LR+L    F GL KL  LHLE +   +I    F  L  LR ++L+ N +  
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462

Query: 244 ISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303
           I +   W  + L  LDL+ N +  +    F+ L  L+ L L  N+L  +  + +      
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRA 522

Query: 304 ISITLSGNMWE 314
             + +S N  E
Sbjct: 523 FWLDVSHNRLE 533



 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 58/195 (29%), Positives = 96/195 (49%), Gaps = 3/195 (1%)

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           G  + L+L  N +Q++K+  F GL  +  + L  N + ++ E  F+G+ +L  L L  + 
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           +  +   TF  +  LR L L  N L  ++ +   GL +L+ L L SN L  +P R+FQ  
Sbjct: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 495

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
             L++L L  NRL  L  +A   L +   L + HN+   +  +    L  LR + L+ N 
Sbjct: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 555

Query: 241 IRSIS---QGLTWTW 252
           +R+ +    GL   W
Sbjct: 556 LRTFTPQPPGLERLW 570


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  125 bits (315), Expect = 8e-29
 Identities = 89/270 (32%), Positives = 129/270 (47%), Gaps = 6/270 (2%)

Query: 33  ACPKNCRC------DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQ 86
           ACP  C C      D   V+C S     +P+ + GG+Q L L  N++  +    F  L+ 
Sbjct: 40  ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99

Query: 87  LIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQ 146
           L +L L    + S++  A  G+  L  L L  N++  L   TF   P L +L LS N+L 
Sbjct: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 159

Query: 147 TLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLK 206
            L+   F+GL  L  L+L  NSL  +P   F+   +L  L L  NRL  L    F+GL +
Sbjct: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219

Query: 207 LKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ 266
           L+EL L  N    I    F +L  L+ +YL  N I +++ G      +L  LDLS N + 
Sbjct: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA 279

Query: 267 GIEPGTFKCLPNLQKLNLDSNKLTNISQET 296
           G+   TF  L  L+ L L  N + ++   T
Sbjct: 280 GLLEDTFPGLLGLRVLRLSHNAIASLRPRT 309



 Score =  124 bits (311), Expect = 2e-28
 Identities = 80/246 (32%), Positives = 124/246 (50%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
           L L  N + +L+   F GL  L  L L  N ++ + + AF+G+  L+EL+L+ N++ YL 
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210

Query: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
              F  +  LR LDLS N L+ +++  F  L +L  L+L  N +  V    F   + L +
Sbjct: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270

Query: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSIS 245
           LDL +NR+  L  + F GLL L+ L L HN  + +    F  L  L  + L  NRIR ++
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330

Query: 246 QGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLIS 305
           +        L  L L  N +Q ++ G F  L N+  +NL  N L N+ ++       L S
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 390

Query: 306 ITLSGN 311
           + L G+
Sbjct: 391 LHLEGS 396



 Score =  123 bits (308), Expect = 5e-28
 Identities = 80/251 (31%), Positives = 133/251 (52%)

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           G  + L L  N +  L+   F+GL +L  L L  N + ++  + F  + RL++L L  N 
Sbjct: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           I  +    F  +  LR LDLS+N++  L  + F GL  L +L L  N++ ++  R F+D 
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
             L+ L LG+NR+R L+  +F GL +L+ L L+HNQ  ++    F  L N+  + L  N 
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373

Query: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
           +R++ + +      LH+L L G+ +  I P TF  L  L++L L  N L  I ++++   
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433

Query: 301 ISLISITLSGN 311
             L+ + L+ N
Sbjct: 434 AELLELDLTSN 444



 Score =  119 bits (297), Expect = 1e-26
 Identities = 81/251 (32%), Positives = 120/251 (47%)

Query: 64  QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITY 123
           Q L L  N I  +    F GL  L WL L HN ++ + ED F G+  L+ L LS N I  
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 304

Query: 124 LHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNL 183
           L  +TF  +  L  L L +N+++ L    F+GL +L +L L  N L+ V    F    N+
Sbjct: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 364

Query: 184 DFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 243
             ++L  N LR+L    F GL KL  LHLE +   +I    F  L  LR ++L+ N +  
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424

Query: 244 ISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303
           I +   W  + L  LDL+ N +  +    F+ L  L+ L L  N+L  +  + +      
Sbjct: 425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRA 484

Query: 304 ISITLSGNMWE 314
             + +S N  E
Sbjct: 485 FWLDVSHNRLE 495



 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 58/195 (29%), Positives = 96/195 (49%), Gaps = 3/195 (1%)

Query: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
           G  + L+L  N +Q++K+  F GL  +  + L  N + ++ E  F+G+ +L  L L  + 
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397

Query: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
           +  +   TF  +  LR L L  N L  ++ +   GL +L+ L L SN L  +P R+FQ  
Sbjct: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457

Query: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
             L++L L  NRL  L  +A   L +   L + HN+   +  +    L  LR + L+ N 
Sbjct: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517

Query: 241 IRSIS---QGLTWTW 252
           +R+ +    GL   W
Sbjct: 518 LRTFTPQPPGLERLW 532


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  125 bits (314), Expect = 1e-28
 Identities = 95/325 (29%), Positives = 150/325 (46%), Gaps = 31/325 (9%)

Query: 17  VLLPTLLLVML------TGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRF 70
           +LL  LLL+ L       G +  C   C C G  + C     A +P ++   ++ L+L +
Sbjct: 18  LLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSY 77

Query: 71  NSIQKLKSNQFAGLNQL-----------------------IWLYLDHNYISSVDEDAFQG 107
           N + ++    F  L  L                       + L+L HN I SV+    + 
Sbjct: 78  NKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKA 137

Query: 108 IRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGL-RKLIILHLRS 166
              L+ L LS N IT + N  F   P ++ L+L+ N++ TL+   F GL R L+ L L  
Sbjct: 138 YLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSK 197

Query: 167 NSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFP 226
           N +  +P+R F+  R L  LDL  NR+R +    F GL  L+ L L+ N  SK+    F 
Sbjct: 198 NRITQLPVRAFKLPR-LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFW 256

Query: 227 RLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDS 286
            L  +  ++L++N +  ++ G  +  ++LH L LS N I  I    +     L +L L  
Sbjct: 257 GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSF 316

Query: 287 NKLTNISQETVNAWISLISITLSGN 311
           N LT + +E++    SL  + LS N
Sbjct: 317 NNLTRLDEESLAELSSLSVLRLSHN 341



 Score =  105 bits (263), Expect = 9e-23
 Identities = 86/300 (28%), Positives = 131/300 (43%), Gaps = 4/300 (1%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
           L L  N I +L    F  L +L  L L+ N I  ++   FQG+  L+ L L  N I+ L 
Sbjct: 193 LRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLT 251

Query: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
           +  F  +  +  L L YN L  + S    GL  L  LHL +NS+  +  + +  C+ L  
Sbjct: 252 DGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHE 311

Query: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSIS 245
           L L +N L  L   + A L  L  L L HN  S I    F  L +LR + L  N I    
Sbjct: 312 LVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371

Query: 246 QGLTWTWS---SLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWIS 302
           +  +  +S   SL  L L GN I+ +    F  L  L+ LNL  N + ++  +      +
Sbjct: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431

Query: 303 LISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSE 362
           L  + +S + + C   +  L  WL         T  CA P+ ++G+ +        +C +
Sbjct: 432 LKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDD 491


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  123 bits (309), Expect = 4e-28
 Identities = 103/352 (29%), Positives = 156/352 (44%), Gaps = 32/352 (9%)

Query: 15  VLVLLPTLLLVMLTGAQRA--CPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRF 70
           +LV+L  L L+++ G  RA  CP  C C  +   V C      ++P+ IS  ++ L+L  
Sbjct: 26  LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHE 85

Query: 71  NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFH 130
           N IQ +K N F  L  L  L L  N+I +++  AF G+                      
Sbjct: 86  NQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL---------------------- 123

Query: 131 PVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLG- 189
              NL  L+L  N+L T+ +  F  L KL  L LR+N ++++P   F    +L  LDLG 
Sbjct: 124 --ANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181

Query: 190 YNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLT 249
             RL  +S  AF GL  L+ L+L      +I   +   L  L  + L  N + +I  G  
Sbjct: 182 LKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSF 239

Query: 250 WTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 309
                L  L +  + IQ IE   F  L +L ++NL  N LT +  +       L  I L 
Sbjct: 240 QGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLH 299

Query: 310 GNMWECSRSICPLFYWLKNF-KGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
            N W C+  I  L +W+K+    N      C  P +++G  + +  + Y  C
Sbjct: 300 HNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  122 bits (305), Expect = 1e-27
 Identities = 110/392 (28%), Positives = 167/392 (42%), Gaps = 25/392 (6%)

Query: 62  GSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 121
           G   L+L  NS+  +    F  L  L  L L  N ++ +    F G+  L+EL L  N+I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239

Query: 122 TYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCR 181
             L    FH   NL+ L LS N +  L    F  L +L  L L  NSLK + + +F    
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299

Query: 182 NLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRI 241
           NL  L L  N + SL  N F+ L +L+ L L  NQ S I+   F  L  LR + L  N +
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359

Query: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWI 301
           + +   +    ++L N+ L  N ++ +    F  +  L  + L +N+L N+     +   
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 419

Query: 302 SLISITLSGNMWECSRSICPLFYW--LKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
            L  + L  N W C   I PL  W  L   +   ++  +C  P +++G+    ++   N+
Sbjct: 420 KLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ----SLIIINV 475

Query: 360 CSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVT--QSTFETPSPSPGF--------- 408
              V  V+       P+TP  P      T   PD T   ST E  SP   +         
Sbjct: 476 NVAVPSVHVPEVPSYPETPWYP-----DTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVT 530

Query: 409 ---QIPGAEQEYEHVSFHKIIAGSVALFLSVA 437
               + G  Q    ++   I+ G VAL  S+A
Sbjct: 531 DDRSVWGMTQAQSGLAIAAIVIGIVALACSLA 562



 Score =  115 bits (289), Expect = 9e-26
 Identities = 86/307 (28%), Positives = 132/307 (42%), Gaps = 25/307 (8%)

Query: 30  AQRACPKNCRCD-GKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLI 88
           A   CP  C C     V C       +P  +   +  L +    I +L  + F  ++ LI
Sbjct: 27  AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 86

Query: 89  WLYLDHNYISSVDEDAF------------------------QGIRRLKELILSSNKITYL 124
            L ++ N +S +   AF                        QG+  L+ L+LSSN++  +
Sbjct: 87  ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 146

Query: 125 HNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
               F    NL+ L L  N L+ +    F  L  L  L+L  NSL  +  RVFQ   NL 
Sbjct: 147 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 206

Query: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI 244
            L L  NRL  +    F GL+ L+EL L+ NQ   ++   F    NL+ +YL  N I  +
Sbjct: 207 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQL 266

Query: 245 SQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLI 304
              +      L+ L L GN ++ +  G F  +PNL++L L  N ++++     +    L 
Sbjct: 267 PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ 326

Query: 305 SITLSGN 311
            + LS N
Sbjct: 327 VLILSRN 333



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/105 (26%), Positives = 51/105 (48%)

Query: 210 LHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
           L + +   +++N + F  +  L ++ ++ N +  I+ G      SL  L L+ N +Q + 
Sbjct: 64  LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123

Query: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWE 314
            G F+ L +L+ L L SN+L  I     +   +L  + L GN  E
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 168


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  122 bits (305), Expect = 1e-27
 Identities = 110/392 (28%), Positives = 167/392 (42%), Gaps = 25/392 (6%)

Query: 62  GSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 121
           G   L+L  NS+  +    F  L  L  L L  N ++ +    F G+  L+EL L  N+I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233

Query: 122 TYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCR 181
             L    FH   NL+ L LS N +  L    F  L +L  L L  NSLK + + +F    
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293

Query: 182 NLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRI 241
           NL  L L  N + SL  N F+ L +L+ L L  NQ S I+   F  L  LR + L  N +
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353

Query: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWI 301
           + +   +    ++L N+ L  N ++ +    F  +  L  + L +N+L N+     +   
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413

Query: 302 SLISITLSGNMWECSRSICPLFYW--LKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
            L  + L  N W C   I PL  W  L   +   ++  +C  P +++G+    ++   N+
Sbjct: 414 KLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ----SLIIINV 469

Query: 360 CSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVT--QSTFETPSPSPGF--------- 408
              V  V+       P+TP  P      T   PD T   ST E  SP   +         
Sbjct: 470 NVAVPSVHVPEVPSYPETPWYP-----DTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVT 524

Query: 409 ---QIPGAEQEYEHVSFHKIIAGSVALFLSVA 437
               + G  Q    ++   I+ G VAL  S+A
Sbjct: 525 DDRSVWGMTQAQSGLAIAAIVIGIVALACSLA 556



 Score =  115 bits (289), Expect = 9e-26
 Identities = 86/307 (28%), Positives = 132/307 (42%), Gaps = 25/307 (8%)

Query: 30  AQRACPKNCRCD-GKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLI 88
           A   CP  C C     V C       +P  +   +  L +    I +L  + F  ++ LI
Sbjct: 21  AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 80

Query: 89  WLYLDHNYISSVDEDAF------------------------QGIRRLKELILSSNKITYL 124
            L ++ N +S +   AF                        QG+  L+ L+LSSN++  +
Sbjct: 81  ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 140

Query: 125 HNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
               F    NL+ L L  N L+ +    F  L  L  L+L  NSL  +  RVFQ   NL 
Sbjct: 141 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200

Query: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI 244
            L L  NRL  +    F GL+ L+EL L+ NQ   ++   F    NL+ +YL  N I  +
Sbjct: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQL 260

Query: 245 SQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLI 304
              +      L+ L L GN ++ +  G F  +PNL++L L  N ++++     +    L 
Sbjct: 261 PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ 320

Query: 305 SITLSGN 311
            + LS N
Sbjct: 321 VLILSRN 327



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/105 (26%), Positives = 51/105 (48%)

Query: 210 LHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
           L + +   +++N + F  +  L ++ ++ N +  I+ G      SL  L L+ N +Q + 
Sbjct: 58  LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117

Query: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWE 314
            G F+ L +L+ L L SN+L  I     +   +L  + L GN  E
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 162


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  119 bits (299), Expect = 6e-27
 Identities = 103/388 (26%), Positives = 163/388 (42%), Gaps = 58/388 (14%)

Query: 20  PTLLLVM---LTGAQRACPKNCRCDG--KIVYCESHAFADIPENISGGSQGLSLRFNSIQ 74
           P LLLV+   L+G+   CP  C C    + V C    F  +PE I   ++ L L  N I+
Sbjct: 25  PILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIK 84

Query: 75  KLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPN 134
            L  ++FA    L  L L+ N +S+V+  AF  +  L+ L L SN++  +    F  + N
Sbjct: 85  TLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSN 144

Query: 135 LRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLR 194
           L  LD+S NK+  L    F+ L  L  L +  N L  +  R F    +L+ L L    L 
Sbjct: 145 LTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLT 204

Query: 195 SLSRNAFA---GLLKLKELHLEHNQFSKINF-----------AHFP-------------- 226
           S+   A +   GL+ L+  HL  N     +F           +H+P              
Sbjct: 205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN 264

Query: 227 --------------------RLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ 266
                                L  LR + L +N I +I   +      L  + L G  + 
Sbjct: 265 LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLA 324

Query: 267 GIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLF--Y 324
            +EP  F+ L  L+ LN+  N+LT + +   ++  +L ++ L  N   C   +  +F   
Sbjct: 325 VVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRR 384

Query: 325 WLKNFKGNKESTMICAGPKHIQGEKVSD 352
           W  NF   + +   CA P+ +QG++  D
Sbjct: 385 WRLNFNRQQPT---CATPEFVQGKEFKD 409


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  119 bits (297), Expect = 1e-26
 Identities = 107/398 (26%), Positives = 171/398 (42%), Gaps = 23/398 (5%)

Query: 22  LLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK-SNQ 80
           L +  L+   ++CP  CRCD   +YC       IP  I   +  L L+ N I      + 
Sbjct: 19  LQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSD 78

Query: 81  FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDL 140
              L ++  +YL HN   S+DE      + +KEL L  N I  +   +   +P L  L L
Sbjct: 79  LKNLLKVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135

Query: 141 SYNKLQTLQSEQ--FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSR 198
             N +  +  E+  F+    L +L L  N L T+P  +    R ++ L L  NR+ ++S 
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISS 192

Query: 199 NAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256
            +  GL  LK L L+ N  +        F  L NL  + L  N + +    L  T  +L 
Sbjct: 193 PSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLR 250

Query: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316
            L L  N I  + P  F  L  L +L++ +N L+N+ Q   +   ++  + L  N W C 
Sbjct: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310

Query: 317 RSICPLFYWLKNF--KGNKESTMICAGPKHIQGEKVSDA------VETYNICSEVQVVNT 368
             +  +  WL++   K N    M C  P+ ++G  + D        +   I S +Q+   
Sbjct: 311 CKMKWVRDWLQSLPVKVNVRGLM-CQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369

Query: 369 ERSHLVPQTPQKPL-IIPRPTIFKPDVTQSTFETPSPS 405
             + + P   Q P  +  +P I  P +T+    T SPS
Sbjct: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPS 407


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  119 bits (297), Expect = 1e-26
 Identities = 107/398 (26%), Positives = 171/398 (42%), Gaps = 23/398 (5%)

Query: 22  LLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK-SNQ 80
           L +  L+   ++CP  CRCD   +YC       IP  I   +  L L+ N I      + 
Sbjct: 19  LQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSD 78

Query: 81  FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDL 140
              L ++  +YL HN   S+DE      + +KEL L  N I  +   +   +P L  L L
Sbjct: 79  LKNLLKVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135

Query: 141 SYNKLQTLQSEQ--FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSR 198
             N +  +  E+  F+    L +L L  N L T+P  +    R ++ L L  NR+ ++S 
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISS 192

Query: 199 NAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256
            +  GL  LK L L+ N  +        F  L NL  + L  N + +    L  T  +L 
Sbjct: 193 PSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLR 250

Query: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316
            L L  N I  + P  F  L  L +L++ +N L+N+ Q   +   ++  + L  N W C 
Sbjct: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310

Query: 317 RSICPLFYWLKNF--KGNKESTMICAGPKHIQGEKVSDA------VETYNICSEVQVVNT 368
             +  +  WL++   K N    M C  P+ ++G  + D        +   I S +Q+   
Sbjct: 311 CKMKWVRDWLQSLPVKVNVRGLM-CQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369

Query: 369 ERSHLVPQTPQKPL-IIPRPTIFKPDVTQSTFETPSPS 405
             + + P   Q P  +  +P I  P +T+    T SPS
Sbjct: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPS 407


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  118 bits (296), Expect = 1e-26
 Identities = 98/363 (26%), Positives = 158/363 (43%), Gaps = 54/363 (14%)

Query: 16  LVLLPTLLLVMLTGAQRACPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSI 73
           ++LL   LL  L  A  ACP+NC C   +  V C+      IP+ +S  ++ L+L+ N+ 
Sbjct: 5   MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63

Query: 74  QKLKSNQFA------------------------GLNQLIWLYLDHNYISSVDEDAFQGIR 109
             L +N F                         GL QLI+LYL HN I  +   AF  + 
Sbjct: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123

Query: 110 RLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169
            L  L L  NK+T L      P+ NL  L L+ NK++ L++  F+G + L  L+L  N+L
Sbjct: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183

Query: 170 KTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLF 229
            ++      D  NL    +  N+L S    A + L  ++EL L HN    I         
Sbjct: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSI--------- 234

Query: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289
                    N  +S  + L   W       L   +++    G F  +  L+ ++L++N+L
Sbjct: 235 -------PDNAFQSFGRYLETLW-------LDNTNLEKFSDGAFLGVTTLKHVHLENNRL 280

Query: 290 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEK 349
             +       + SL ++ L+ N W+C+  +  L  WL+      ++T  CA P   +G+ 
Sbjct: 281 NQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKGQH 336

Query: 350 VSD 352
           + D
Sbjct: 337 IRD 339


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  118 bits (295), Expect = 2e-26
 Identities = 91/332 (27%), Positives = 148/332 (44%), Gaps = 30/332 (9%)

Query: 33  ACPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWL 90
           +CP  C C  +   V C     A++P +I   ++ L+L+ N IQ ++++ F  L  L  L
Sbjct: 56  SCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEIL 115

Query: 91  YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
            L  N +  ++  AF G+                        P+L  L+L  N+L T+ +
Sbjct: 116 QLSKNLVRKIEVGAFNGL------------------------PSLNTLELFDNRLTTVPT 151

Query: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLG-YNRLRSLSRNAFAGLLKLKE 209
           + F+ L KL  L LR+N ++++P   F    +L  LDLG   RL  +S  AF GL+ L+ 
Sbjct: 152 QAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRY 211

Query: 210 LHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
           L+L       I   +   L  L  + L  NR+  I  G     +SL  L L    +  IE
Sbjct: 212 LNLGMCNLKDI--PNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIE 269

Query: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLK-N 328
              F  L +L++LNL  N L ++  +       L  + L+ N W C+  +  L +WLK  
Sbjct: 270 RNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKET 329

Query: 329 FKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
              N      C  P  ++G  + +  +++  C
Sbjct: 330 VPSNTTCCARCHAPAGLKGRYIGELDQSHFTC 361


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  115 bits (288), Expect = 1e-25
 Identities = 83/308 (26%), Positives = 144/308 (46%), Gaps = 13/308 (4%)

Query: 15  VLVLLPTLLLVMLTGAQ-------RACPKNCRC--DGKI---VYCESHAFADIPENISGG 62
           VL+ LP LL +   G+        R CP +C C  DG++   V C     +++P N+S  
Sbjct: 8   VLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVF 67

Query: 63  SQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKIT 122
           +  L L  N+I +L  N    L  L  L L  N ++ + + AF G+  LK L+L +N++ 
Sbjct: 68  TSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR 127

Query: 123 YLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRN 182
           ++  +    + +L++L L  N +  +    F GL  L  L L  N+L  +P++ F+    
Sbjct: 128 HVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSA 187

Query: 183 LDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIR 242
           L  + L  N++  +   AF  L  L  LHL +N+   +    F  L +L ++ L +N + 
Sbjct: 188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD 247

Query: 243 SISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWIS 302
                +  T S+L  L    N+I+ I    F   P+L  ++   N +  + +        
Sbjct: 248 EFPTAIR-TLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPE 306

Query: 303 LISITLSG 310
           L ++TL+G
Sbjct: 307 LRTLTLNG 314



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 90/198 (45%), Gaps = 4/198 (2%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
           L L +N++ +  +     L+ L  L    N I S+ E AF G   L  +    N I ++ 
Sbjct: 239 LDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297

Query: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
              F  +P LR L L+    Q  +     G   L  L L    + ++P  V     NL  
Sbjct: 298 RSAFQHLPELRTLTLN-GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQV 356

Query: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSIS 245
           LDL YN L  L   +F+   KL+++ L HN+  +I    F +L +LRS+ L WN+I  I 
Sbjct: 357 LDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH 414

Query: 246 QGLTWTWSSLHNLDLSGN 263
                T  SL  LDLS N
Sbjct: 415 PNAFSTLPSLIKLDLSSN 432



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 51/174 (29%), Positives = 82/174 (47%)

Query: 138 LDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLS 197
           LDLS N +  L       LR L  L L  N+L  +P   F    +L  L L  N+LR + 
Sbjct: 71  LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130

Query: 198 RNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHN 257
             A   L  L+ L L+ N  S +  + F  L +LR ++L  N +  I      + S+L  
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190

Query: 258 LDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
           + L+ N I  I    F  L +L  L+L +N++ ++ ++  +   SL ++ L+ N
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYN 244



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 22/188 (11%)

Query: 41  DGKIVYCESHAFADIPE----NISGGSQ--------------GLSLRFNSIQKLKSNQFA 82
           D  I +    AF  +PE     ++G SQ               L+L    I  L      
Sbjct: 290 DNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCN 349

Query: 83  GLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
            L  L  L L +N +   D  +F   ++L+++ L  N+I  +   TF  + +LR+L+L++
Sbjct: 350 QLPNLQVLDLSYNLLE--DLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAW 407

Query: 143 NKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFA 202
           NK+  +    F  L  LI L L SN L + PI       +L     G + L+SL  +   
Sbjct: 408 NKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL--TGNHALQSLISSENF 465

Query: 203 GLLKLKEL 210
             LK+ E+
Sbjct: 466 PELKVIEM 473


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  114 bits (285), Expect = 3e-25
 Identities = 105/403 (26%), Positives = 171/403 (42%), Gaps = 37/403 (9%)

Query: 9   LKGMSVVLVLLPTLLLVM-----LTGAQRACPKNCRCD----GKIVYCESHAFADIPENI 59
           +KG  ++++LL  ++L +     +    RACP  C C     G  V C+      +P  +
Sbjct: 1   MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60

Query: 60  SGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSN 119
              +  + L  N ++ L    F  L  L  L L HN +S +   AF+G+ RL EL L+ N
Sbjct: 61  PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120

Query: 120 -KITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE-----------------------QFKG 155
             + YLH +TF  +  LR LDL+  +L ++                            +G
Sbjct: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180

Query: 156 LRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN 215
           L  L   HL    ++ V     Q  R L  L L  NR+R++   AF     L+ L L  N
Sbjct: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240

Query: 216 QFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKC 275
             +++    F  L  LR++ L  N +  +++      + L  L L  N I  +E G F+ 
Sbjct: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN 300

Query: 276 LPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKES 335
           L  L  L+L+ N+LT ++         L  + L  N W C   +  L  W++     + +
Sbjct: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG--SGRVT 358

Query: 336 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTP 378
            + CA P  + G  +S    T+   S+   V+ E  +L   +P
Sbjct: 359 DVPCASPGSVAGLDLSQV--TFGRSSDGLCVDPEELNLTTSSP 399


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  114 bits (285), Expect = 3e-25
 Identities = 79/278 (28%), Positives = 128/278 (46%), Gaps = 2/278 (0%)

Query: 34  CPKNCRCDG-KIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYL 92
           C   C CDG + V C       +PE +S  +Q L +  N+I +L  + F     L  L L
Sbjct: 29  CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88

Query: 93  DHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQ 152
             N +S +   A  G++ LK L L +N++  + ++    +  L++L L  N + ++  + 
Sbjct: 89  AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148

Query: 153 FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL 212
           F+GL +L  L L  NSL  VP+    +   L  L L  N++ S+   AF  L  L  LHL
Sbjct: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208

Query: 213 EHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGT 272
            +N+   ++   F  L NL ++ L +N +    Q +     SL  L    N I  I  G 
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIK-ALPSLKELGFHSNSISVIPDGA 267

Query: 273 FKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSG 310
           F   P L+ ++L  N L+ +     +    L S+ + G
Sbjct: 268 FDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 74/294 (25%), Positives = 115/294 (39%), Gaps = 34/294 (11%)

Query: 41  DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSV 100
           D  +     H  +++P       Q L+L  N I  +    F  L+ L+ L+L +N I S+
Sbjct: 162 DNSLTEVPVHPLSNLPT-----LQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216

Query: 101 DEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLI 160
            +  F G+  L+ L L+ N +     +    +P+L+ L    N +  +    F G   L 
Sbjct: 217 SQHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR 275

Query: 161 ILHLRSNSLKTVPIRVFQDCRNL-----------------------DFLDLGYNRLRSLS 197
            +HL  N L  V    F +  +L                       + L L   ++ S+ 
Sbjct: 276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIP 335

Query: 198 RNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHN 257
            N       L+ L L +N    +    F     L  I LQ N+I  I +G      SL  
Sbjct: 336 NNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRI 393

Query: 258 LDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
           LDLS N I  I    F  L  +  L++  N+LT+   E +N    L  + L GN
Sbjct: 394 LDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLN---GLNQLKLVGN 444



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 21/80 (26%), Positives = 37/80 (46%)

Query: 232 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTN 291
           +++ +  N I  + +     +  L  L L+GND+  I P     L  L+ L L +N+L  
Sbjct: 60  QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119

Query: 292 ISQETVNAWISLISITLSGN 311
           +  E +    +L S+ L  N
Sbjct: 120 VPSEAIRGLSALQSLRLDAN 139


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score =  114 bits (284), Expect = 3e-25
 Identities = 83/273 (30%), Positives = 132/273 (48%), Gaps = 2/273 (0%)

Query: 35  PKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
           P  C C G  + C+      +P ++S     +SL++N I+KL  + F   + L  LYL +
Sbjct: 101 PVQCLCQGLELDCDETNLRAVP-SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159

Query: 95  NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFK 154
           N I+S+   AF+G+  L +L LS N+IT+L    F  +  L  L +  N L  +    F 
Sbjct: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219

Query: 155 GLRKLIILHLRSNSLKTVPIR-VFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLE 213
           GL  LI+L L +N L  +P + + Q    L +LDL  N + +L    F     L  L + 
Sbjct: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279

Query: 214 HNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTF 273
            N+ + +N   F  L  L  + L  N+I ++   +      L  L+LS N IQ I+   F
Sbjct: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339

Query: 274 KCLPNLQKLNLDSNKLTNISQETVNAWISLISI 306
             L  L+ L+L+  +++NI Q      ++L  I
Sbjct: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 76/249 (30%), Positives = 111/249 (44%), Gaps = 27/249 (10%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSV-DEDAFQGIRRLKELILSSNKITYL 124
           L +  N + ++    F GLN LI L L +N ++ + D+   Q + RL  L L  N I  L
Sbjct: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNL 262

Query: 125 HNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
            N TF    NL  L +  NK+  L    F  L+KL  L L SN ++ +P  +F+D + L 
Sbjct: 263 RNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELS 322

Query: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI 244
            L+L YN ++ +  N F  L+KLK L LE  + S I    F  L NL  IY +       
Sbjct: 323 QLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFK------- 375

Query: 245 SQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLI 304
                                 G  P    C PN   ++   N L +I Q  V  W+ + 
Sbjct: 376 -----------------KFQYCGYAPHVRSCKPNTDGISSLENLLASIIQR-VFVWV-VS 416

Query: 305 SITLSGNMW 313
           ++T  GN++
Sbjct: 417 AVTCFGNIF 425



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 52/182 (28%), Positives = 86/182 (47%), Gaps = 1/182 (0%)

Query: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
           N+  + L +N ++ L  + FK    L  L+L++N + ++ I  F+   +L  L L +NR+
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186

Query: 194 RSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI-SQGLTWTW 252
             L    F  L +L+ L +E N  S+I+   F  L +L  + L  N +  +  + L    
Sbjct: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246

Query: 253 SSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
             LH LDL GN I  +   TF    NL  L +  NK+ ++++ T      L  + L  N 
Sbjct: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306

Query: 313 WE 314
            E
Sbjct: 307 IE 308



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 50/167 (29%), Positives = 78/167 (46%), Gaps = 13/167 (7%)

Query: 171 TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFN 230
           +VP++       LD  +     + S+S N  A       + L+ N   K+    F    +
Sbjct: 99  SVPVQCLCQGLELDCDETNLRAVPSVSSNVTA-------MSLQWNLIRKLPPDCFKNYHD 151

Query: 231 LRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLT 290
           L+ +YLQ N+I SIS       +SL  L LS N I  ++PG F+ L  L+ L ++ N L+
Sbjct: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211

Query: 291 NISQETVNAWISLISITLSGNMWE--CSRSIC---PLFYWLKNFKGN 332
            IS  T     SLI + L  N+      + +C   P  +WL + +GN
Sbjct: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWL-DLEGN 257


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score =  113 bits (283), Expect = 4e-25
 Identities = 114/447 (25%), Positives = 184/447 (41%), Gaps = 57/447 (12%)

Query: 34  CPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLD 93
           CP  CRCD   +YC       IP +I   +  L L+ N I      Q   L   + + + 
Sbjct: 54  CPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQ--DLKTKVNVQVI 111

Query: 94  HNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQ- 152
           + Y + +DE      R L+EL L  N +  +   +   +P L  L L  N + T+  E+ 
Sbjct: 112 YLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEED 171

Query: 153 -FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELH 211
            F   ++L +L L  N L ++P  +      L+ L L  NR+ ++  +AF GL  L+ L 
Sbjct: 172 AFADSKQLKLLFLSRNHLSSIPSGL---PHTLEELRLDDNRISTIPLHAFKGLNSLRRLV 228

Query: 212 LEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
           L+ N  +    A   F RL NL  + L  N +   +  L    + L  L L  N I  I 
Sbjct: 229 LDGNLLANQRIADDTFSRLQNLTELSLVRNSL--AAPPLNLPSAHLQKLYLQDNAISHIP 286

Query: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLK-- 327
             T   +  L++L+L +N LT + +   +   +L  + L  N W C  ++  L  W+K  
Sbjct: 287 YNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKAR 346

Query: 328 ----NFKGNKESTMICAGPKHIQGEKVSDAVETYNICSE---------VQVVNTERSHLV 374
               N +G     ++C GP+ ++G  + D     + C E              T  +H  
Sbjct: 347 AAVVNVRG-----LMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHAS 401

Query: 375 PQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHVSFHKIIAGSVALFL 434
             TPQ                 S F   +  PG ++P +  +Y       +  G  A  L
Sbjct: 402 ATTPQ----------------GSLFTLKAKRPGLRLPDSNIDY------PMATGDGAKTL 439

Query: 435 SVAMILLV---IYVSWK-RYPASMKQL 457
           ++ +  L    I ++WK   PAS  +L
Sbjct: 440 AIHVKALTADSIRITWKATLPASSFRL 466


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  112 bits (281), Expect = 7e-25
 Identities = 96/363 (26%), Positives = 152/363 (41%), Gaps = 37/363 (10%)

Query: 15  VLVLLPTLLLVMLTGAQRACPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNS 72
           V +L   +      G Q  CP  C C  +   V C     +++P+ I   ++ L+L  N+
Sbjct: 28  VWILCAAIAAAASAGPQN-CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENN 86

Query: 73  IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
           IQ ++++ F  L+ L  L L  N I  ++  AF G+                        
Sbjct: 87  IQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGL------------------------ 122

Query: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLG-YN 191
            +L  L+L  N L  + S  F+ L KL  L LR+N ++++P   F    +L  LDLG   
Sbjct: 123 ASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELK 182

Query: 192 RLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPR---LFNLRSIYLQWNRIRSISQGL 248
           +L  +S  AF GL  LK L+L        N    P    L  L  + +  N    I  G 
Sbjct: 183 KLEYISEGAFEGLFNLKYLNL-----GMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGS 237

Query: 249 TWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITL 308
               SSL  L +  + +  IE   F  L +L +LNL  N L+++  +       L+ + L
Sbjct: 238 FHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHL 297

Query: 309 SGNMWECSRSICPLFYWLKNF-KGNKESTMICAGPKHIQGEKVSDAVETYNICSEVQVVN 367
             N W C   I  L +WL+ +   N      C  P H++G  + +  +    CS   +++
Sbjct: 298 HHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMD 357

Query: 368 TER 370
             R
Sbjct: 358 APR 360


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score =  109 bits (273), Expect = 6e-24
 Identities = 90/340 (26%), Positives = 153/340 (45%), Gaps = 35/340 (10%)

Query: 21  TLLLVMLTGAQR----ACPKNCRC----DGKIVYCESHAFADIPENISGGSQGLSLRFNS 72
           TL L++L  A        PK+C+      G  + C+  A  +IP  +   +  L++ F +
Sbjct: 22  TLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA--EIPGYLPADTVHLAVEFFN 79

Query: 73  IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
           +  L +N   G ++L  L+L  N + S+  +  + + +L+ L L+ N +T L    F   
Sbjct: 80  LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139

Query: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192
             L  L L  N+L+ L+     GL+ L  L L  N L+ +P  +  +   L  LDLG N+
Sbjct: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199

Query: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTW 252
           L +L  +   G L+L+ LHLE N+   +         +LR ++L  N++  ++ G     
Sbjct: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL 259

Query: 253 SSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKLTNISQETVNAWISLISITLSG 310
             L  LDLS N +  +  G +  L  PN                     W       +SG
Sbjct: 260 RQLDMLDLSNNSLASVPEGLWASLGQPN---------------------WDMRDGFDISG 298

Query: 311 NMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQGE 348
           N W C +++  L+ WL+  K     ++   CAGP+ ++G+
Sbjct: 299 NPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQ 338


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score =  109 bits (272), Expect = 8e-24
 Identities = 83/297 (27%), Positives = 137/297 (46%), Gaps = 34/297 (11%)

Query: 34  CPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLD 93
           CP  C C  ++V C       +P+ IS  +  L L+ N I +L+ + F GL  L  L L 
Sbjct: 63  CPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLV 122

Query: 94  HNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQF 153
           +N IS + E AF  +R+L++L +S N +  +        PNL +                
Sbjct: 123 NNKISKIHEKAFSPLRKLQKLYISKNHLVEI-------PPNLPS---------------- 159

Query: 154 KGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRS--LSRNAFAGLLKLKELH 211
                L+ L +  N ++ VP  VF   RN++ +++G N L +      AF G LKL  L 
Sbjct: 160 ----SLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDG-LKLNYLR 214

Query: 212 LEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPG 271
           +   + + I     P   N   ++L  N+I++I       +S L+ L L  N I+ IE G
Sbjct: 215 ISEAKLTGIP-KDLPETLN--ELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENG 271

Query: 272 TFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECS-RSICPLFYWLK 327
           +   LP L++L+LD+NKL  +     +  +  +    S N+ +      CP+ + +K
Sbjct: 272 SLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGFGVK 328


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  109 bits (272), Expect = 8e-24
 Identities = 88/329 (26%), Positives = 144/329 (43%), Gaps = 54/329 (16%)

Query: 22  LLLVMLTGAQRACPKNCRCDGK--IVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSN 79
           L+L+ L  A  +CP  C C      V C+++ F+ +P ++   +Q L L+ N I+ L+  
Sbjct: 19  LMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPG 78

Query: 80  QFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLD 139
            F      +WL+                          SN ++ ++  TF  +  L  LD
Sbjct: 79  TFGSNLLTLWLF--------------------------SNNLSTIYPGTFRHLQALEELD 112

Query: 140 LSYNK-LQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSR 198
           L  N+ L++L+ + F+GL +L  LHL    L ++P                         
Sbjct: 113 LGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLP------------------------G 148

Query: 199 NAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNL 258
           N F GL+ L+ L+L+ N    +    F  L NL  ++L  NR+R +++ +     SL  L
Sbjct: 149 NIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRL 208

Query: 259 DLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRS 318
            L GN +QG+    F+ L  L  L L +N L ++  E +    SL  + L+ N W C   
Sbjct: 209 LLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCR 268

Query: 319 ICPLFYWLKNFKGNKESTMICAGPKHIQG 347
             PL+ W +  + +  S + CA P   QG
Sbjct: 269 ARPLWAWFQRARVS-SSDVTCATPPERQG 296


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  108 bits (271), Expect = 1e-23
 Identities = 76/284 (26%), Positives = 132/284 (46%), Gaps = 5/284 (1%)

Query: 33  ACPKNCRC--DGKIVY--CESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLI 88
           ACP  C C  DG ++   C     + +P ++   +  L L  N++ +L+   F  L  L 
Sbjct: 34  ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93

Query: 89  WLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTL 148
            L L  N++S +   AF G+  LK L+L +N++  +  +    +P+L++L L  N +  +
Sbjct: 94  ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 153

Query: 149 QSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLK 208
               F+GL  L  L L  N+L  +P+R   +   L  + L  NR+  +   AF  L  L 
Sbjct: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 213

Query: 209 ELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGI 268
            LHL +N+   +    F  L NL ++ L +N+++     +  T   L  L    N+I+ I
Sbjct: 214 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIR-TLGRLQELGFHNNNIKAI 272

Query: 269 EPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
               F   P LQ ++   N +  + +        L +++L+G M
Sbjct: 273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM 316



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 81/250 (32%), Positives = 116/250 (46%), Gaps = 13/250 (5%)

Query: 66  LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
           L L  N IQ L ++ F GL+ L  L L++N +      A + + RL+EL   +N I  + 
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIP 273

Query: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCR---N 182
            K F   P L+ +    N +Q +    F+ L KL  L L       + I+ F D +   +
Sbjct: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQEFPDLKGTTS 329

Query: 183 LDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIR 242
           L+ L L    +R L       L +L+ L L HNQ  ++   H  R   L  I LQ NRI 
Sbjct: 330 LEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH--RCQKLEEIGLQHNRIW 387

Query: 243 SISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWIS 302
            I        SSL  LDLS N I+ I P  F  L +L KL+L  N+LT +    +     
Sbjct: 388 EIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG---G 444

Query: 303 LISITLSGNM 312
           L+ + L GN+
Sbjct: 445 LMHLKLKGNL 454


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,077,973
Number of Sequences: 37866
Number of extensions: 1084939
Number of successful extensions: 6148
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 3218
Number of HSP's gapped (non-prelim): 1269
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.