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Search of human proteins with 197383077
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
(596 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens] 1225 0.0
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens] 822 0.0
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 427 e-119
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens] 325 9e-89
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 323 4e-88
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens] 322 5e-88
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens] 200 3e-51
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens] 197 3e-50
gi|109638745 transforming growth factor beta 1 induced transcrip... 169 5e-42
gi|21361591 transforming growth factor beta 1 induced transcript... 169 5e-42
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens] 162 8e-40
gi|221316659 leupaxin isoform 1 [Homo sapiens] 155 1e-37
gi|4758670 leupaxin isoform 2 [Homo sapiens] 155 1e-37
gi|170932518 paxillin isoform 3 [Homo sapiens] 147 2e-35
gi|170932516 paxillin isoform 2 [Homo sapiens] 147 2e-35
gi|170932514 paxillin isoform 1 [Homo sapiens] 147 2e-35
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens] 141 1e-33
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo... 131 2e-30
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo... 131 2e-30
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo... 131 2e-30
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor... 131 2e-30
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ... 127 3e-29
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens] 124 3e-28
gi|54112385 four and a half LIM domains 3 [Homo sapiens] 119 6e-27
gi|13994151 PDZ and LIM domain 1 [Homo sapiens] 114 3e-25
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens] 108 2e-23
gi|87159836 four and a half LIM domains 2 [Homo sapiens] 105 1e-22
gi|87159834 four and a half LIM domains 2 [Homo sapiens] 105 1e-22
gi|42403575 four and a half LIM domains 2 [Homo sapiens] 105 1e-22
gi|87159832 four and a half LIM domains 2 [Homo sapiens] 105 1e-22
>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
Length = 596
Score = 1225 bits (3169), Expect = 0.0
Identities = 596/596 (100%), Positives = 596/596 (100%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST 120
MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST 120
Query: 121 NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH 180
NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH
Sbjct: 121 NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH 180
Query: 181 ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPR 240
ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPR
Sbjct: 181 ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPR 240
Query: 241 KHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEA 300
KHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEA
Sbjct: 241 KHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEA 300
Query: 301 DNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS 360
DNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS
Sbjct: 301 DNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS 360
Query: 361 PSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC 420
PSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC
Sbjct: 361 PSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC 420
Query: 421 AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECG 480
AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECG
Sbjct: 421 AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECG 480
Query: 481 RCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHG 540
RCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHG
Sbjct: 481 RCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHG 540
Query: 541 CEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF 596
CEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Sbjct: 541 CEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF 596
>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
Length = 487
Score = 822 bits (2122), Expect = 0.0
Identities = 390/392 (99%), Positives = 392/392 (100%)
Query: 205 RQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRL 264
++PTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRL
Sbjct: 96 QKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRL 155
Query: 265 IEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTR 324
IEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTR
Sbjct: 156 IEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTR 215
Query: 325 SMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSG 384
SMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSG
Sbjct: 216 SMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSG 275
Query: 385 SVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF 444
SVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF
Sbjct: 276 SVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF 335
Query: 445 NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFV 504
NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFV
Sbjct: 336 NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFV 395
Query: 505 CVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCF 564
CVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCF
Sbjct: 396 CVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCF 455
Query: 565 VCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF 596
VCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Sbjct: 456 VCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF 487
Score = 197 bits (500), Expect = 3e-50
Identities = 97/97 (100%), Positives = 97/97 (100%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
Length = 617
Score = 427 bits (1098), Expect = e-119
Identities = 255/669 (38%), Positives = 342/669 (51%), Gaps = 130/669 (19%)
Query: 3 NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62
+YSV+L GP PWGFRLQGGKDFNMPLTIS + G KAAQ+ + GD+V++IDG+N MT
Sbjct: 2 SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
Query: 63 HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNN 122
HLEAQNKIK + +L++TLQ++ P+P+ P V P+P+ V S N
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSK-----RPIPISTTAPP-VQTPLPVIPHQKVVVNSPAN 115
Query: 123 MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHAN 182
Y + F P+ S+ ++ P+
Sbjct: 116 ADYQER---------------------FNPSALKDSALSTHKPIEV-------------- 140
Query: 183 ANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKH 242
L T ++ ++ + + GQ + +QG + P +
Sbjct: 141 ---------KGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQ-AQGSDFSGSLPIKDL 190
Query: 243 IVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGT--------EH 294
V+ + Y S + ++ ++W R+ QSRSFRILAQ+TGT E
Sbjct: 191 AVDSASPVYQAVIKSQNKPE---DEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEA 247
Query: 295 LKESE----------------ADNTKKANNSQEPSPQ-LASSVASTRS-----MPESLDS 332
L+ S A +T + P+P+ + AS R +P S S
Sbjct: 248 LRRSRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYS 307
Query: 333 PTSGR---PGVTSLTAAAAFKPVGSTGVIKSP-SWQRPNQG---VPSTGRISN---SATY 382
P+ G P + + A A+ P + SP P+ PS N S Y
Sbjct: 308 PSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAY 367
Query: 383 SGSVA------------------------------------PANSALGQTQPSDQDTLVQ 406
SG A PA + G P VQ
Sbjct: 368 SGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQ 427
Query: 407 RAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALY 466
RAE PA RTP+C HCN VIRGPFLVA+G+SWHPEEF CA+CK ++A + FVEE+ +Y
Sbjct: 428 RAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVY 487
Query: 467 CELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 526
CE CYE+FFAP C +C KI+GEV+ AL+QTWH +CFVC AC KP N++FH+EDGEPYC
Sbjct: 488 CERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 547
Query: 527 ETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPL 586
E DY LF T CHGC+FP+EAGD F+EALG+TWHDTCF+C+VC +LEGQ F+SKKD+PL
Sbjct: 548 EKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPL 607
Query: 587 CKKHAHSVN 595
CKKHAH++N
Sbjct: 608 CKKHAHTIN 616
>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
Length = 457
Score = 325 bits (832), Expect = 9e-89
Identities = 166/363 (45%), Positives = 221/363 (60%), Gaps = 40/363 (11%)
Query: 234 QQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTE 293
QQNG P + +V DASK+RL+E+TEDWRPR GT QSRSFRILA +TGTE
Sbjct: 130 QQNGQPLRPLVP------------DASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTE 177
Query: 294 HLKESEADNTKKANNSQEPSPQLASSVASTRSMP---ESLDSPTSGRPGVTSLTAAAAFK 350
+++ + ++ KK+ SQ P + + +ST P + SPTS P A +
Sbjct: 178 FMQDPDEEHLKKS--SQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYA 235
Query: 351 PVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEH 410
P ++ V+ S +P P R S +G V S G
Sbjct: 236 PDKTSTVLTRHS--QPATPTPLQSRTSIVQAAAGGVPGGGSNNG---------------- 277
Query: 411 IPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELC 470
+TP+C C++VIRG +LVALG ++HPEEF C+ C + GF EEKGA++C C
Sbjct: 278 -----KTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPC 332
Query: 471 YEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY 530
Y+ +AP C +C++KI GE++ ALK TWHV CF C AC PIRN F++E+G PYCE DY
Sbjct: 333 YDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDY 392
Query: 531 YALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+FGT CHGC+F I+AGD FLEALG++WHDTCFVC++C +LEG+TF+SKKD+PLCK H
Sbjct: 393 EKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 452
Query: 591 AHS 593
A S
Sbjct: 453 AFS 455
Score = 124 bits (310), Expect = 3e-28
Identities = 72/146 (49%), Positives = 89/146 (60%), Gaps = 19/146 (13%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
M ++ V L GPAPWGFRLQGGKDFN+PL+IS L GGKAAQA V +GD VLSIDG NA
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVS--KVT 118
+TH+EAQNKI+ C L++ L RA PVQ KP ++PA + T
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQ--------PVQS-------KPQKASAPAADPPRYT 105
Query: 119 STNNMAYNKAPRPFGSVSSPKVTSIP 144
+++ NK RPFG + P S P
Sbjct: 106 FAPSVSLNKTARPFG--APPPADSAP 129
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 323 bits (827), Expect = 4e-88
Identities = 180/453 (39%), Positives = 240/453 (52%), Gaps = 37/453 (8%)
Query: 155 ATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCS 214
+T HA A TP L A++ A A+ SA P A +A TA+ + ++
Sbjct: 299 STPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAI-----ASASTTAP 353
Query: 215 ETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPR 274
+S + + S + + P H Y+E P +PR
Sbjct: 354 ASSPADSPRPQASSYSPAVAASSAPATHT--SYSEGPAAPAP---------------KPR 396
Query: 275 TGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRS---MPESLD 331
TT S + + + + S N + P+P S A + +P
Sbjct: 397 VVTTASIRPSVYQPVPASTY-SPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTP 455
Query: 332 SPTSG---------RPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATY 382
SP P + + +P + S+ + ST IS
Sbjct: 456 SPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLP 515
Query: 383 SGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPE 442
G PA + G P VQRAE PA RTP+C HCN VIRGPFLVA+G+SWHPE
Sbjct: 516 RGG--PAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPE 573
Query: 443 EFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSC 502
EF CA+CK ++A + FVEE+ +YCE CYE+FFAP C +C KI+GEV+ AL+QTWH +C
Sbjct: 574 EFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTC 633
Query: 503 FVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDT 562
FVC AC KP N++FH+EDGEPYCE DY LF T CHGC+FP+EAGD F+EALG+TWHDT
Sbjct: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
Query: 563 CFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVN 595
CF+C+VC +LEGQ F+SKKD+PLCKKHAH++N
Sbjct: 694 CFICAVCHVNLEGQPFYSKKDRPLCKKHAHTIN 726
Score = 180 bits (456), Expect = 4e-45
Identities = 131/412 (31%), Positives = 204/412 (49%), Gaps = 41/412 (9%)
Query: 3 NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62
+YSV+L GP PWGFRLQGGKDFNMPLTIS + G KAAQ+ + GD+V++IDG+N MT
Sbjct: 2 SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
Query: 63 HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNN 122
HLEAQNKIK + +L++TLQ++ P+P+ P V P+P+ TN
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSK-----RPIPISTTAP-PVQTPLPVIPHQKDPALDTNG 115
Query: 123 MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHAN 182
+P P + +SP P F+PA + S+ +S + + PP
Sbjct: 116 SLVAPSPSP-EARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPP---------R 165
Query: 183 ANLSADQSPSALS--AGKTAVNVPRQP-----TVTSVCSETSQELAEGQRRGSQGDSKQQ 235
A+L A SP G A+ QP + +ET +E+A+ + +G +
Sbjct: 166 ASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGV 225
Query: 236 NGP----PRKHI-VERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQIT 290
P P K + V+ + Y S + ++ ++W R+ QSRSFRILAQ+T
Sbjct: 226 GLPGGSLPIKDLAVDSASPVYQAVIKSQNKPE---DEADEWARRSSNLQSRSFRILAQMT 282
Query: 291 GTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTS--LTAAAA 348
GTE +++ + + ++++ E +P + +S A+T +P S P + P S L AAA
Sbjct: 283 GTEFMQDPDEEALRRSSTPIEHAP-VCTSQATTPLLPASAQPPAAASPSAASPPLATAAA 341
Query: 349 FKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSD 400
+ S S P+ +++YS +VA +++ T S+
Sbjct: 342 HTAIASASTTAPAS-------SPADSPRPQASSYSPAVAASSAPATHTSYSE 386
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 25/156 (16%)
Query: 84 ASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSI 143
A+ APKP V P V +PVP A +P P + S T
Sbjct: 389 AAPAPKPRVVTTASIRPS-VYQPVP---------------ASTYSPSPGANYSPTPYTPS 432
Query: 144 PSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNV 203
P+P+ +PA A T PSPV TP A + + + +PS +G A
Sbjct: 433 PAPAYTPSPAPAYT-----PSPVPTYTPS--PAPAYTPSPAPNYNPAPSVAYSGGPAEPA 485
Query: 204 PRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPP 239
R P VT SQ+ A G+ S G P
Sbjct: 486 SRPPWVTD--DSFSQKFAPGKSTTSISKQTLPRGGP 519
>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
Length = 423
Score = 322 bits (826), Expect = 5e-88
Identities = 161/343 (46%), Positives = 214/343 (62%), Gaps = 28/343 (8%)
Query: 254 PTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPS 313
P DASK+RL+E+TEDWRPR GT QSRSFRILA +TGTE +++ + ++ KK+ SQ P
Sbjct: 104 PLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKS--SQVPR 161
Query: 314 PQLASSVASTRSMP---ESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGV 370
+ + +ST P + SPTS P A + P ++ V+ S +P
Sbjct: 162 TEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHS--QPATPT 219
Query: 371 PSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGP 430
P R S +G V S G +TP+C C++VIRG
Sbjct: 220 PLQSRTSIVQAAAGGVPGGGSNNG---------------------KTPVCHQCHKVIRGR 258
Query: 431 FLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV 490
+LVALG ++HPEEF C+ C + GF EEKGA++C CY+ +AP C +C++KI GE+
Sbjct: 259 YLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI 318
Query: 491 ISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDM 550
+ ALK TWHV CF C AC PIRN F++E+G PYCE DY +FGT CHGC+F I+AGD
Sbjct: 319 MHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDR 378
Query: 551 FLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 593
FLEALG++WHDTCFVC++C +LEG+TF+SKKD+PLCK HA S
Sbjct: 379 FLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFS 421
Score = 117 bits (292), Expect = 4e-26
Identities = 60/107 (56%), Positives = 73/107 (68%), Gaps = 1/107 (0%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
M ++ V L GPAPWGFRLQGGKDFN+PL+IS L GGKAAQA V +GD VLSIDG NA
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRAS-AAPKPEPVPVQKGEPKEVVKP 106
+TH+EAQNKI+ C L++ L RA KP+ V +P + P
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVP 107
>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
Length = 234
Score = 200 bits (509), Expect = 3e-51
Identities = 100/108 (92%), Positives = 102/108 (94%), Gaps = 6/108 (5%)
Query: 205 RQPTVTSVCSETSQELAEGQRRGSQGDSKQQNG------PPRKHIVERYTEFYHVPTHSD 258
++PTVTSVCSETSQELAEGQRRGSQGDSKQQNG PPRKHIVERYTEFYHVPTHSD
Sbjct: 96 QKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSD 155
Query: 259 ASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKA 306
ASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKA
Sbjct: 156 ASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKA 203
Score = 197 bits (500), Expect = 3e-50
Identities = 97/97 (100%), Positives = 97/97 (100%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
Length = 214
Score = 197 bits (500), Expect = 3e-50
Identities = 97/97 (100%), Positives = 97/97 (100%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQK 97
Score = 145 bits (366), Expect = 1e-34
Identities = 69/69 (100%), Positives = 69/69 (100%)
Query: 238 PPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKE 297
PPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKE
Sbjct: 115 PPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKE 174
Query: 298 SEADNTKKA 306
SEADNTKKA
Sbjct: 175 SEADNTKKA 183
>gi|109638745 transforming growth factor beta 1 induced transcript 1
isoform 1 [Homo sapiens]
Length = 461
Score = 169 bits (429), Expect = 5e-42
Identities = 96/298 (32%), Positives = 144/298 (48%), Gaps = 24/298 (8%)
Query: 309 SQEPSPQLASSV-----ASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSW 363
SQ PS ++AS + + P SP+ G P ++ +A + + S S
Sbjct: 113 SQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRL-----MASLSD 167
Query: 364 QRPNQGVPSTGRISN---SATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTP-- 418
R +P++G S+T GS +P T DT++ + + + P
Sbjct: 168 FRVQNHLPASGPTQPPVVSSTNEGSPSPPEP----TGKGSLDTMLGLLQSDLSRRGVPTQ 223
Query: 419 ---MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
+C CN+ I G + ALG++WHPE F C C + F E+ GA +C CY + F
Sbjct: 224 AKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERF 283
Query: 476 APECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535
+P CG C + I ++++AL WH F CV+CG+P + FH +G PYC D+ LF
Sbjct: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
Query: 536 TICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 593
C GC+ PI D ++ AL WH CFVC C G +FF + +PLC+ H H+
Sbjct: 344 PRCQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 399
Score = 141 bits (355), Expect = 2e-33
Identities = 132/499 (26%), Positives = 191/499 (38%), Gaps = 86/499 (17%)
Query: 118 TSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPA----------------HATTSSHA 161
T+T++M + AP+ P P PS P ++T
Sbjct: 13 TTTSHMPRSGAPK-----ERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPR 67
Query: 162 SPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELA 221
SP P A PP ++SG+ D+ L+A T N+ T + S ++A
Sbjct: 68 SPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNA--TQFNI----TDEIMSQFPSSKVA 121
Query: 222 EGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKK----RLIEDTEDWR----- 272
G+++ Q + K++ P + +P S S RL+ D+R
Sbjct: 122 SGEQKEDQSEDKKRPSLPS-------SPSPGLPKASATSATLELDRLMASLSDFRVQNHL 174
Query: 273 PRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDS 332
P +G TQ + N PSP + S +M L S
Sbjct: 175 PASGPTQPP---------------------VVSSTNEGSPSPPEPTGKGSLDTMLGLLQS 213
Query: 333 PTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSA 392
S R GV P + G+ S + Q V + GR + + ++A
Sbjct: 214 DLSRR-GV----------PTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFV--CGGCSTA 260
Query: 393 LGQTQPSDQDTLVQRAEHIPA---GKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHC 449
LG + ++D A P + +P C CNQ IR + ALG WHPE F C C
Sbjct: 261 LGGSSFFEKDG----APFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSC 316
Query: 450 KNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACG 509
GF E +G YC + + FAP C CQ IL ISAL WH CFVC C
Sbjct: 317 GEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECF 376
Query: 510 KPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVC 569
P F +G P CE ++A G++C C P+ + ALG +H F C+ C
Sbjct: 377 APFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTG--RCVSALGRRFHPDHFTCTFC 434
Query: 570 CESLEGQTFFSKKDKPLCK 588
L +F + KP C+
Sbjct: 435 LRPLTKGSFQERAGKPYCQ 453
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/118 (30%), Positives = 51/118 (43%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C I ++ AL WHP+ F C C + F E +G CE +
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535
C C + G +SAL + +H F C C +P+ F G+PYC+ + LFG
Sbjct: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
Score = 50.4 bits (119), Expect = 5e-06
Identities = 21/61 (34%), Positives = 31/61 (50%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +CA C + G + ALG+ +HP+ F C C + F E G YC+ C+ K
Sbjct: 400 RRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKL 459
Query: 475 F 475
F
Sbjct: 460 F 460
>gi|21361591 transforming growth factor beta 1 induced transcript 1
isoform 2 [Homo sapiens]
Length = 444
Score = 169 bits (429), Expect = 5e-42
Identities = 96/298 (32%), Positives = 144/298 (48%), Gaps = 24/298 (8%)
Query: 309 SQEPSPQLASSV-----ASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSW 363
SQ PS ++AS + + P SP+ G P ++ +A + + S S
Sbjct: 96 SQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRL-----MASLSD 150
Query: 364 QRPNQGVPSTGRISN---SATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTP-- 418
R +P++G S+T GS +P T DT++ + + + P
Sbjct: 151 FRVQNHLPASGPTQPPVVSSTNEGSPSPPEP----TGKGSLDTMLGLLQSDLSRRGVPTQ 206
Query: 419 ---MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
+C CN+ I G + ALG++WHPE F C C + F E+ GA +C CY + F
Sbjct: 207 AKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERF 266
Query: 476 APECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535
+P CG C + I ++++AL WH F CV+CG+P + FH +G PYC D+ LF
Sbjct: 267 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 326
Query: 536 TICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 593
C GC+ PI D ++ AL WH CFVC C G +FF + +PLC+ H H+
Sbjct: 327 PRCQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 382
Score = 140 bits (353), Expect = 3e-33
Identities = 122/447 (27%), Positives = 176/447 (39%), Gaps = 65/447 (14%)
Query: 154 HATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVC 213
++T SP P A PP ++SG+ D+ L+A T N+ T +
Sbjct: 43 YSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNA--TQFNI----TDEIMS 96
Query: 214 SETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKK----RLIEDTE 269
S ++A G+++ Q + K++ P + +P S S RL+
Sbjct: 97 QFPSSKVASGEQKEDQSEDKKRPSLPS-------SPSPGLPKASATSATLELDRLMASLS 149
Query: 270 DWR-----PRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTR 324
D+R P +G TQ + N PSP + S
Sbjct: 150 DFRVQNHLPASGPTQPP---------------------VVSSTNEGSPSPPEPTGKGSLD 188
Query: 325 SMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSG 384
+M L S S R GV P + G+ S + Q V + GR + +
Sbjct: 189 TMLGLLQSDLSRR-GV----------PTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFV- 236
Query: 385 SVAPANSALGQTQPSDQDTLVQRAEHIPA---GKRTPMCAHCNQVIRGPFLVALGKSWHP 441
++ALG + ++D A P + +P C CNQ IR + ALG WHP
Sbjct: 237 -CGGCSTALGGSSFFEKDG----APFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHP 291
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVS 501
E F C C GF E +G YC + + FAP C CQ IL ISAL WH
Sbjct: 292 EHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPD 351
Query: 502 CFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHD 561
CFVC C P F +G P CE ++A G++C C P+ + ALG +H
Sbjct: 352 CFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTG--RCVSALGRRFHP 409
Query: 562 TCFVCSVCCESLEGQTFFSKKDKPLCK 588
F C+ C L +F + KP C+
Sbjct: 410 DHFTCTFCLRPLTKGSFQERAGKPYCQ 436
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/118 (30%), Positives = 51/118 (43%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C I ++ AL WHP+ F C C + F E +G CE +
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535
C C + G +SAL + +H F C C +P+ F G+PYC+ + LFG
Sbjct: 387 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 444
Score = 50.4 bits (119), Expect = 5e-06
Identities = 21/61 (34%), Positives = 31/61 (50%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +CA C + G + ALG+ +HP+ F C C + F E G YC+ C+ K
Sbjct: 383 RRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKL 442
Query: 475 F 475
F
Sbjct: 443 F 443
>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
Length = 330
Score = 162 bits (410), Expect = 8e-40
Identities = 111/330 (33%), Positives = 170/330 (51%), Gaps = 34/330 (10%)
Query: 3 NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62
+YSV+L GP PWGFRLQGGKDFNMPLTIS + G KAAQ+ + GD+V++IDG+N MT
Sbjct: 2 SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
Query: 63 HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNN 122
HLEAQNKIK + +L++TLQ++ P+P+ P V P+P+ TN
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSK-----RPIPISTTAP-PVQTPLPVIPHQKDPALDTNG 115
Query: 123 MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHAN 182
+P P + +SP P F+PA + S+ +S + + PP
Sbjct: 116 SLVAPSPSP-EARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPP---------R 165
Query: 183 ANLSADQSPSALS--AGKTAVNVPRQP-----TVTSVCSETSQELAEGQRRGSQGDSKQQ 235
A+L A SP G A+ QP + +ET +E+A+ + +G +
Sbjct: 166 ASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGV 225
Query: 236 NGP----PRKHI-VERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQIT 290
P P K + V+ + Y S + ++ ++W R+ QSRSFRILAQ+T
Sbjct: 226 GLPGGSLPIKDLAVDSASPVYQAVIKSQNKPE---DEADEWARRSSNLQSRSFRILAQMT 282
Query: 291 GTEHLKESEADNTKKAN---NSQEPSPQLA 317
GTE +++ + + +++ ++ SP+ A
Sbjct: 283 GTEFMQDPDEEALRRSRERFETERNSPRFA 312
>gi|221316659 leupaxin isoform 1 [Homo sapiens]
Length = 391
Score = 155 bits (392), Expect = 1e-37
Identities = 77/206 (37%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 387 APANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNC 446
A +S LG + QD + +P G CA C + I G + ALG+SWHPE F C
Sbjct: 131 ASLDSMLGGLEQELQDLGIAT---VPKGH----CASCQKPIAGKVIHALGQSWHPEHFVC 183
Query: 447 AHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCV 506
HCK + F E G YC Y + F+P C C IL +V++A+ QTWH F C
Sbjct: 184 THCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCS 243
Query: 507 ACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVC 566
CG+ FH +D +PYC D+ A+F C GC P+ + +L A+ WH CFVC
Sbjct: 244 HCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVL--ENYLSAMDTVWHPECFVC 301
Query: 567 SVCCESLEGQTFFSKKDKPLCKKHAH 592
C S +FF +P C+ H H
Sbjct: 302 GDCFTSFSTGSFFELDGRPFCELHYH 327
Score = 137 bits (346), Expect = 2e-32
Identities = 64/172 (37%), Positives = 86/172 (50%), Gaps = 2/172 (1%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P CA+C I L A+ ++WHPE F C+HC GF E+ YC + F+
Sbjct: 213 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 272
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
P+CG C R +L +SA+ WH CFVC C F DG P+CE Y+ GT
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 332
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
+CHGC PI + A+GY +H FVC+ C L F + DK C+
Sbjct: 333 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 382
Score = 74.3 bits (181), Expect = 3e-13
Identities = 37/118 (31%), Positives = 55/118 (46%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P C CN+ + +L A+ WHPE F C C + + F E G +CEL Y
Sbjct: 272 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 331
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF 534
C C + I G ISA+ +H FVC C + +F ++ + YC+ + LF
Sbjct: 332 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389
Score = 50.1 bits (118), Expect = 6e-06
Identities = 22/61 (36%), Positives = 32/61 (52%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +C C Q I G + A+G +HPE F CA C ++ F E+ YC+ C+ K
Sbjct: 329 RRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKL 388
Query: 475 F 475
F
Sbjct: 389 F 389
Score = 40.0 bits (92), Expect = 0.006
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 538 CHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV 594
C C+ PI AG + + ALG +WH FVC+ C E + FF + C H +
Sbjct: 157 CASCQKPI-AGKV-IHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQL 211
>gi|4758670 leupaxin isoform 2 [Homo sapiens]
Length = 386
Score = 155 bits (392), Expect = 1e-37
Identities = 77/206 (37%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 387 APANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNC 446
A +S LG + QD + +P G CA C + I G + ALG+SWHPE F C
Sbjct: 126 ASLDSMLGGLEQELQDLGIAT---VPKGH----CASCQKPIAGKVIHALGQSWHPEHFVC 178
Query: 447 AHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCV 506
HCK + F E G YC Y + F+P C C IL +V++A+ QTWH F C
Sbjct: 179 THCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCS 238
Query: 507 ACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVC 566
CG+ FH +D +PYC D+ A+F C GC P+ + +L A+ WH CFVC
Sbjct: 239 HCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVL--ENYLSAMDTVWHPECFVC 296
Query: 567 SVCCESLEGQTFFSKKDKPLCKKHAH 592
C S +FF +P C+ H H
Sbjct: 297 GDCFTSFSTGSFFELDGRPFCELHYH 322
Score = 137 bits (346), Expect = 2e-32
Identities = 64/172 (37%), Positives = 86/172 (50%), Gaps = 2/172 (1%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P CA+C I L A+ ++WHPE F C+HC GF E+ YC + F+
Sbjct: 208 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 267
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
P+CG C R +L +SA+ WH CFVC C F DG P+CE Y+ GT
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 327
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
+CHGC PI + A+GY +H FVC+ C L F + DK C+
Sbjct: 328 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 377
Score = 74.3 bits (181), Expect = 3e-13
Identities = 37/118 (31%), Positives = 55/118 (46%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P C CN+ + +L A+ WHPE F C C + + F E G +CEL Y
Sbjct: 267 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 326
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF 534
C C + I G ISA+ +H FVC C + +F ++ + YC+ + LF
Sbjct: 327 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384
Score = 50.1 bits (118), Expect = 6e-06
Identities = 22/61 (36%), Positives = 32/61 (52%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +C C Q I G + A+G +HPE F CA C ++ F E+ YC+ C+ K
Sbjct: 324 RRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKL 383
Query: 475 F 475
F
Sbjct: 384 F 384
Score = 40.0 bits (92), Expect = 0.006
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 538 CHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV 594
C C+ PI AG + + ALG +WH FVC+ C E + FF + C H +
Sbjct: 152 CASCQKPI-AGKV-IHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQL 206
>gi|170932518 paxillin isoform 3 [Homo sapiens]
Length = 424
Score = 147 bits (372), Expect = 2e-35
Identities = 71/172 (41%), Positives = 90/172 (52%), Gaps = 2/172 (1%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P C +CN I + AL ++WHPE F CA C GF E+ G YC Y FA
Sbjct: 247 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 306
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
P+CG C R IL ISAL WH CFVC C P N F DG+PYCE Y+ G+
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
+C GC+ PI + A+ +H FVC+ C + L TF + DKP C+
Sbjct: 367 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 416
Score = 146 bits (369), Expect = 5e-35
Identities = 66/174 (37%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C + I G + A+GK+WHPE F C HC+ + F E G YCE Y F+P
Sbjct: 190 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 249
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
C C IL +V++AL +TWH F C CG FH +DG+ YC DY+ +F C
Sbjct: 250 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 309
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAH 592
GC I + ++ AL WH CFVC C +FF +P C+ H H
Sbjct: 310 GGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYH 361
Score = 82.4 bits (202), Expect = 1e-15
Identities = 39/117 (33%), Positives = 55/117 (47%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I ++ AL WHPE F C C F E G YCE+ Y +
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF 534
C CQ+ I G I+A+ + +H FVC C K + F ++ +PYC+ + LF
Sbjct: 367 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 423
Score = 48.9 bits (115), Expect = 1e-05
Identities = 21/61 (34%), Positives = 32/61 (52%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +C+ C + I G + A+ K +HPE F CA C + F E+ YC+ C+ K
Sbjct: 363 RRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKL 422
Query: 475 F 475
F
Sbjct: 423 F 423
Score = 48.5 bits (114), Expect = 2e-05
Identities = 22/58 (37%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV 594
+C C+ PI AG + + A+G TWH FVC+ C E + + FF + +P C+K H++
Sbjct: 190 VCGACKKPI-AGQV-VTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 245
>gi|170932516 paxillin isoform 2 [Homo sapiens]
Length = 557
Score = 147 bits (372), Expect = 2e-35
Identities = 71/172 (41%), Positives = 90/172 (52%), Gaps = 2/172 (1%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P C +CN I + AL ++WHPE F CA C GF E+ G YC Y FA
Sbjct: 380 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 439
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
P+CG C R IL ISAL WH CFVC C P N F DG+PYCE Y+ G+
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
+C GC+ PI + A+ +H FVC+ C + L TF + DKP C+
Sbjct: 500 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 549
Score = 146 bits (369), Expect = 5e-35
Identities = 66/174 (37%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C + I G + A+GK+WHPE F C HC+ + F E G YCE Y F+P
Sbjct: 323 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 382
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
C C IL +V++AL +TWH F C CG FH +DG+ YC DY+ +F C
Sbjct: 383 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 442
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAH 592
GC I + ++ AL WH CFVC C +FF +P C+ H H
Sbjct: 443 GGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYH 494
Score = 82.4 bits (202), Expect = 1e-15
Identities = 39/117 (33%), Positives = 55/117 (47%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I ++ AL WHPE F C C F E G YCE+ Y +
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF 534
C CQ+ I G I+A+ + +H FVC C K + F ++ +PYC+ + LF
Sbjct: 500 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 556
Score = 48.9 bits (115), Expect = 1e-05
Identities = 21/61 (34%), Positives = 32/61 (52%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +C+ C + I G + A+ K +HPE F CA C + F E+ YC+ C+ K
Sbjct: 496 RRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKL 555
Query: 475 F 475
F
Sbjct: 556 F 556
Score = 48.5 bits (114), Expect = 2e-05
Identities = 22/58 (37%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV 594
+C C+ PI AG + + A+G TWH FVC+ C E + + FF + +P C+K H++
Sbjct: 323 VCGACKKPI-AGQV-VTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 378
>gi|170932514 paxillin isoform 1 [Homo sapiens]
Length = 591
Score = 147 bits (372), Expect = 2e-35
Identities = 71/172 (41%), Positives = 90/172 (52%), Gaps = 2/172 (1%)
Query: 417 TPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFA 476
+P C +CN I + AL ++WHPE F CA C GF E+ G YC Y FA
Sbjct: 414 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 473
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
P+CG C R IL ISAL WH CFVC C P N F DG+PYCE Y+ G+
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
+C GC+ PI + A+ +H FVC+ C + L TF + DKP C+
Sbjct: 534 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 583
Score = 146 bits (369), Expect = 5e-35
Identities = 66/174 (37%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C + I G + A+GK+WHPE F C HC+ + F E G YCE Y F+P
Sbjct: 357 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 416
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
C C IL +V++AL +TWH F C CG FH +DG+ YC DY+ +F C
Sbjct: 417 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 476
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAH 592
GC I + ++ AL WH CFVC C +FF +P C+ H H
Sbjct: 477 GGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYH 528
Score = 82.4 bits (202), Expect = 1e-15
Identities = 39/117 (33%), Positives = 55/117 (47%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I ++ AL WHPE F C C F E G YCE+ Y +
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF 534
C CQ+ I G I+A+ + +H FVC C K + F ++ +PYC+ + LF
Sbjct: 534 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 590
Score = 48.9 bits (115), Expect = 1e-05
Identities = 21/61 (34%), Positives = 32/61 (52%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
+R +C+ C + I G + A+ K +HPE F CA C + F E+ YC+ C+ K
Sbjct: 530 RRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKL 589
Query: 475 F 475
F
Sbjct: 590 F 590
Score = 48.5 bits (114), Expect = 2e-05
Identities = 22/58 (37%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV 594
+C C+ PI AG + + A+G TWH FVC+ C E + + FF + +P C+K H++
Sbjct: 357 VCGACKKPI-AGQV-VTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 412
>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
Length = 283
Score = 141 bits (356), Expect = 1e-33
Identities = 95/318 (29%), Positives = 150/318 (47%), Gaps = 57/318 (17%)
Query: 3 NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62
+YSV+L GP PWGFRLQGGKDFNMPLTIS + G KAAQ+ + GD+V++IDG+N MT
Sbjct: 2 SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
Query: 63 HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNN 122
HLEAQNKIK + +L++TLQ++ P+P+ P V P+P+ V S N
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSK-----RPIPISTTAP-PVQTPLPVIPHQKVVVNSPAN 115
Query: 123 MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHAN 182
Y + F P+ S+ ++ P+
Sbjct: 116 ADYQE---------------------RFNPSALKDSALSTHKPIEV-------------- 140
Query: 183 ANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKH 242
L T ++ ++ + + GQ + +QG + P +
Sbjct: 141 ---------KGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQ-AQGSDFSGSLPIKDL 190
Query: 243 IVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADN 302
V+ + Y S + ++ ++W R+ QSRSFRILAQ+TGTE +++ + +
Sbjct: 191 AVDSASPVYQAVIKSQNKPE---DEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEA 247
Query: 303 TKKAN---NSQEPSPQLA 317
+++ ++ SP+ A
Sbjct: 248 LRRSRERFETERNSPRFA 265
>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
1 [Homo sapiens]
Length = 363
Score = 131 bits (329), Expect = 2e-30
Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C+ VI L+ ++HP+ FNC HC + E KG LYC C++K P
Sbjct: 161 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 219
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
CG C+R I G V++AL + WHV FVC C KP + + + G YCET Y LFG +C
Sbjct: 220 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 279
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589
+ C IE GD+ + AL W +CF CS C L + F + D KP+CK+
Sbjct: 280 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 329
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I G + A+ +WHP F C C +A +GFV+ G C C+ + A
Sbjct: 96 PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 155
Query: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532
C RC I + + +H F C CGK + L+ GE YC +
Sbjct: 156 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 214
Query: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+ IC C PIE + ALG WH FVC+ C + G + KK C+ H
Sbjct: 215 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 270
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P+C C + I G + ALGK WH E F CA C+ E+KG YCE Y + F
Sbjct: 218 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 277
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 530
C C I G+V+SAL + W VSCF C C + N F D +P C+ Y
Sbjct: 278 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 331
Score = 70.1 bits (170), Expect = 5e-12
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)
Query: 479 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C RCQ + ++++ + +H CFVC C +P +F+ +G YCE D+ LF
Sbjct: 37 CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 96
Query: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
C C EF I ++A+ WH CF C +C L F + LC+
Sbjct: 97 CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 146
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G+ +H F CA C F E +G YCE ++ FAP CG C I+G VI A+
Sbjct: 55 GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 114
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550
WH CF C C + + F G C + L IC C I+ +
Sbjct: 115 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 174
Query: 551 FLEALGYTWHDTCFVCSVCCESLEGQ 576
+ Y H F C+ C + L +
Sbjct: 175 MFRSDAY--HPDHFNCTHCGKELTAE 198
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474
+C +C+ VI G + AL K+W F+C+ C + + FVE C+ CYEKF
Sbjct: 278 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 334
Score = 34.7 bits (78), Expect = 0.26
Identities = 13/57 (22%), Positives = 25/57 (43%)
Query: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
AL +C C+ + + + G +H+ CFVC+ C F+ + + C+
Sbjct: 31 ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 87
>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
5 [Homo sapiens]
Length = 336
Score = 131 bits (329), Expect = 2e-30
Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C+ VI L+ ++HP+ FNC HC + E KG LYC C++K P
Sbjct: 134 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 192
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
CG C+R I G V++AL + WHV FVC C KP + + + G YCET Y LFG +C
Sbjct: 193 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 252
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589
+ C IE GD+ + AL W +CF CS C L + F + D KP+CK+
Sbjct: 253 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 302
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I G + A+ +WHP F C C +A +GFV+ G C C+ + A
Sbjct: 69 PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 128
Query: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532
C RC I + + +H F C CGK + L+ GE YC +
Sbjct: 129 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 187
Query: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+ IC C PIE + ALG WH FVC+ C + G + KK C+ H
Sbjct: 188 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 243
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P+C C + I G + ALGK WH E F CA C+ E+KG YCE Y + F
Sbjct: 191 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 250
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 530
C C I G+V+SAL + W VSCF C C + N F D +P C+ Y
Sbjct: 251 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 304
Score = 70.1 bits (170), Expect = 5e-12
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)
Query: 479 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C RCQ + ++++ + +H CFVC C +P +F+ +G YCE D+ LF
Sbjct: 10 CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 69
Query: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
C C EF I ++A+ WH CF C +C L F + LC+
Sbjct: 70 CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 119
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G+ +H F CA C F E +G YCE ++ FAP CG C I+G VI A+
Sbjct: 28 GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 87
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550
WH CF C C + + F G C + L IC C I+ +
Sbjct: 88 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 147
Query: 551 FLEALGYTWHDTCFVCSVCCESLEGQ 576
+ Y H F C+ C + L +
Sbjct: 148 MFRSDAY--HPDHFNCTHCGKELTAE 171
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474
+C +C+ VI G + AL K+W F+C+ C + + FVE C+ CYEKF
Sbjct: 251 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 307
Score = 34.7 bits (78), Expect = 0.26
Identities = 13/57 (22%), Positives = 25/57 (43%)
Query: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
AL +C C+ + + + G +H+ CFVC+ C F+ + + C+
Sbjct: 4 ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 60
>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
3 [Homo sapiens]
Length = 341
Score = 131 bits (329), Expect = 2e-30
Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C+ VI L+ ++HP+ FNC HC + E KG LYC C++K P
Sbjct: 139 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 197
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
CG C+R I G V++AL + WHV FVC C KP + + + G YCET Y LFG +C
Sbjct: 198 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 257
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589
+ C IE GD+ + AL W +CF CS C L + F + D KP+CK+
Sbjct: 258 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 307
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I G + A+ +WHP F C C +A +GFV+ G C C+ + A
Sbjct: 74 PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 133
Query: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532
C RC I + + +H F C CGK + L+ GE YC +
Sbjct: 134 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 192
Query: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+ IC C PIE + ALG WH FVC+ C + G + KK C+ H
Sbjct: 193 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 248
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P+C C + I G + ALGK WH E F CA C+ E+KG YCE Y + F
Sbjct: 196 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 255
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 530
C C I G+V+SAL + W VSCF C C + N F D +P C+ Y
Sbjct: 256 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 309
Score = 70.1 bits (170), Expect = 5e-12
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)
Query: 479 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C RCQ + ++++ + +H CFVC C +P +F+ +G YCE D+ LF
Sbjct: 15 CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 74
Query: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
C C EF I ++A+ WH CF C +C L F + LC+
Sbjct: 75 CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 124
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G+ +H F CA C F E +G YCE ++ FAP CG C I+G VI A+
Sbjct: 33 GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 92
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550
WH CF C C + + F G C + L IC C I+ +
Sbjct: 93 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 152
Query: 551 FLEALGYTWHDTCFVCSVCCESLEGQ 576
+ Y H F C+ C + L +
Sbjct: 153 MFRSDAY--HPDHFNCTHCGKELTAE 176
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474
+C +C+ VI G + AL K+W F+C+ C + + FVE C+ CYEKF
Sbjct: 256 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 312
Score = 34.7 bits (78), Expect = 0.26
Identities = 13/57 (22%), Positives = 25/57 (43%)
Query: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
AL +C C+ + + + G +H+ CFVC+ C F+ + + C+
Sbjct: 9 ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 65
>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
[Homo sapiens]
Length = 365
Score = 131 bits (329), Expect = 2e-30
Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C+ VI L+ ++HP+ FNC HC + E KG LYC C++K P
Sbjct: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
CG C+R I G V++AL + WHV FVC C KP + + + G YCET Y LFG +C
Sbjct: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589
+ C IE GD+ + AL W +CF CS C L + F + D KP+CK+
Sbjct: 282 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 331
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I G + A+ +WHP F C C +A +GFV+ G C C+ + A
Sbjct: 98 PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
Query: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532
C RC I + + +H F C CGK + L+ GE YC +
Sbjct: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 216
Query: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+ IC C PIE + ALG WH FVC+ C + G + KK C+ H
Sbjct: 217 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P+C C + I G + ALGK WH E F CA C+ E+KG YCE Y + F
Sbjct: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 530
C C I G+V+SAL + W VSCF C C + N F D +P C+ Y
Sbjct: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 333
Score = 70.1 bits (170), Expect = 5e-12
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)
Query: 479 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C RCQ + ++++ + +H CFVC C +P +F+ +G YCE D+ LF
Sbjct: 39 CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
Query: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
C C EF I ++A+ WH CF C +C L F + LC+
Sbjct: 99 CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G+ +H F CA C F E +G YCE ++ FAP CG C I+G VI A+
Sbjct: 57 GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 116
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550
WH CF C C + + F G C + L IC C I+ +
Sbjct: 117 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 176
Query: 551 FLEALGYTWHDTCFVCSVCCESLEGQ 576
+ Y H F C+ C + L +
Sbjct: 177 MFRSDAY--HPDHFNCTHCGKELTAE 200
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474
+C +C+ VI G + AL K+W F+C+ C + + FVE C+ CYEKF
Sbjct: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 336
Score = 34.7 bits (78), Expect = 0.26
Identities = 13/57 (22%), Positives = 25/57 (43%)
Query: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
AL +C C+ + + + G +H+ CFVC+ C F+ + + C+
Sbjct: 33 ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
sapiens]
Length = 325
Score = 127 bits (319), Expect = 3e-29
Identities = 68/172 (39%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478
+C C+ +I L+ +HP+ FNCA+C + E KG LYC C++K P
Sbjct: 134 ICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELT-ADARELKGELYCLPCHDKMGVPI 192
Query: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538
CG C+R I G V++A+ + WHV FVC C KP + + G YCET Y LFG +C
Sbjct: 193 CGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVC 252
Query: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589
C IE GD+ + AL W CF CS C L + F + D KP+CKK
Sbjct: 253 FHCNRVIE-GDV-VSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKK 302
Score = 94.0 bits (232), Expect = 4e-19
Identities = 55/178 (30%), Positives = 79/178 (44%), Gaps = 8/178 (4%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P C C + I G + A+ SWHPE F C C+ +A IGFV+ G C C+ + A
Sbjct: 69 PCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKAR 128
Query: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532
C +C I + + +H F C CGK + + L+ GE YC +
Sbjct: 129 GLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELK-GELYCLPCHDK 187
Query: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
+ IC C PIE + A+G WH FVC+ C + G + +K C+ H
Sbjct: 188 MGVPICGACRRPIEG--RVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETH 243
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
P+C C + I G + A+GK WH E F CA C+ E KG YCE Y + F
Sbjct: 191 PICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGD 250
Query: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACG-KPIRNNVFHLEDGEPYCETDY 530
C C R I G+V+SAL + W V+CF C C K N F D +P C+ Y
Sbjct: 251 VCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCY 304
Score = 69.3 bits (168), Expect = 9e-12
Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 6/113 (5%)
Query: 479 CGRCQRKILG--EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C RC+ +++++ + +H CFVC C + +F+ +G YCE D+ LF
Sbjct: 10 CERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAP 69
Query: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
CH C EF I ++A+ +WH CF C +C E L F + LC+
Sbjct: 70 CCHQCGEFII---GRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCR 119
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/143 (29%), Positives = 61/143 (42%), Gaps = 7/143 (4%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G+ +H + F CA C F E +G YCE ++ FAP C +C I+G VI A+
Sbjct: 28 GELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMN 87
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550
+WH CF C C + + + F G C + L IC C I+ +
Sbjct: 88 NSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPL 147
Query: 551 FLEALGYTWHDTCFVCSVCCESL 573
+ Y H F C+ C + L
Sbjct: 148 IFKNDPY--HPDHFNCANCGKEL 168
Score = 46.2 bits (108), Expect = 8e-05
Identities = 23/57 (40%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474
+C HCN+VI G + AL K+W F C+ C + FVE C+ CYEKF
Sbjct: 251 VCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKF 307
Score = 33.5 bits (75), Expect = 0.57
Identities = 13/57 (22%), Positives = 25/57 (43%)
Query: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
AL C C+ + + + G +H+ CFVC+ C + F+ + + C+
Sbjct: 4 ALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCE 60
>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
Length = 222
Score = 124 bits (310), Expect = 3e-28
Identities = 72/146 (49%), Positives = 89/146 (60%), Gaps = 19/146 (13%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
M ++ V L GPAPWGFRLQGGKDFN+PL+IS L GGKAAQA V +GD VLSIDG NA
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVS--KVT 118
+TH+EAQNKI+ C L++ L RA PVQ KP ++PA + T
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQ--------PVQS-------KPQKASAPAADPPRYT 105
Query: 119 STNNMAYNKAPRPFGSVSSPKVTSIP 144
+++ NK RPFG + P S P
Sbjct: 106 FAPSVSLNKTARPFG--APPPADSAP 129
Score = 72.8 bits (177), Expect = 8e-13
Identities = 37/73 (50%), Positives = 50/73 (68%), Gaps = 12/73 (16%)
Query: 234 QQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTE 293
QQNG P + +V DASK+RL+E+TEDWRPR GT QSRSFRILA +TGTE
Sbjct: 130 QQNGQPLRPLVP------------DASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTE 177
Query: 294 HLKESEADNTKKA 306
+++ + ++ KK+
Sbjct: 178 FMQDPDEEHLKKS 190
>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
Length = 280
Score = 119 bits (299), Expect = 6e-27
Identities = 56/155 (36%), Positives = 75/155 (48%), Gaps = 2/155 (1%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G++WH F C+ C+ + FV +KGA YC CYE FAP C RC + + ++
Sbjct: 119 GQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRD 178
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIE--AGDMFLE 553
Q WH C VC C P+ F D +PYC + LF C C+ PI G ++
Sbjct: 179 QPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVS 238
Query: 554 ALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
WH CF C+ C SL GQ F D+ LC+
Sbjct: 239 FEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273
Score = 89.0 bits (219), Expect = 1e-17
Identities = 45/149 (30%), Positives = 69/149 (46%), Gaps = 4/149 (2%)
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISAL---KQTW 498
E F+CA C ++ +++ YC CY+ FA C CQ+ ++G L + +
Sbjct: 3 ESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQ-LIGHDSRELFYEDRHF 61
Query: 499 HVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYT 558
H CF C C + + + F +D E C Y + F + C C + G LE G T
Sbjct: 62 HEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQT 121
Query: 559 WHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH+ CF+CS C + L ++F K C
Sbjct: 122 WHEHCFLCSGCEQPLGSRSFVPDKGAHYC 150
Score = 88.2 bits (217), Expect = 2e-17
Identities = 50/172 (29%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Query: 420 CAHCNQVIRGPF--LVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477
CA C Q+I L + +H F C C+ ++A F + L C CY F+
Sbjct: 40 CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSS 99
Query: 478 ECGRCQRKIL--GEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535
+C C ++ + QTWH CF+C C +P+ + F + G YC Y F
Sbjct: 100 QCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFA 159
Query: 536 TICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
C C + G + WH C VC+ C L GQ F S+ + P C
Sbjct: 160 PRCARCSKTLTQGGVTYR--DQPWHRECLVCTGCQTPLAGQQFTSRDEDPYC 209
Score = 66.6 bits (161), Expect = 6e-11
Identities = 36/131 (27%), Positives = 56/131 (42%), Gaps = 16/131 (12%)
Query: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474
K P CA C++ + + + WH E C C+ +A F YC C+ +
Sbjct: 157 KFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGEL 216
Query: 475 FAPECGRCQRKIL----GEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY 530
FAP+C C+R I+ G+ +S + WH +CF C C + F + DG+
Sbjct: 217 FAPKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGF-VPDGDQ------ 269
Query: 531 YALFGTICHGC 541
+C GC
Sbjct: 270 -----VLCQGC 275
>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
Length = 329
Score = 114 bits (284), Expect = 3e-25
Identities = 82/236 (34%), Positives = 116/236 (49%), Gaps = 16/236 (6%)
Query: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
M+ + L GP PWGFRL GGKDF PL IS + G KAA AN+ IGDV+ +IDG N
Sbjct: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
Query: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST 120
MTHLEAQN+IKGCT +L +T+ R S P+ ++G+ + V + S
Sbjct: 61 MTHLEAQNRIKGCTDNLTLTVAR-SEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGS- 118
Query: 121 NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH 180
A+N++ PF + + T+ + PA +S + S A + AASG+
Sbjct: 119 ---AHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKT--AASGVE 173
Query: 181 ANAN-LSADQSPSALSAGKTA--------VNVPRQPTVTSVCSETSQELAEGQRRG 227
AN+ L Q PS+L K + +P S QE+ E + +G
Sbjct: 174 ANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKG 229
Score = 35.8 bits (81), Expect = 0.11
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCE 527
P C +C I+G + + H C+VC CG ++ + + YCE
Sbjct: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
Score = 35.4 bits (80), Expect = 0.15
Identities = 18/61 (29%), Positives = 26/61 (42%)
Query: 408 AEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYC 467
A I ++ PMC C I G F+ + HPE + C C + G + +YC
Sbjct: 248 AASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYC 307
Query: 468 E 468
E
Sbjct: 308 E 308
Score = 31.2 bits (69), Expect = 2.8
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLCKKHA 591
H C+VC+ C +L+ + F +D+ C+KHA
Sbjct: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311
>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
Length = 373
Score = 108 bits (269), Expect = 2e-23
Identities = 58/183 (31%), Positives = 91/183 (49%), Gaps = 8/183 (4%)
Query: 394 GQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVI--RGPFLVALGKSWHPEEFNCAHCKN 451
G +P +++ AE + G T +CA C++ + R + A+ + +H + F C C+
Sbjct: 157 GPLRPMEEELPPPPAEPVEKGASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRR 216
Query: 452 TMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKP 511
+A F ++ G CE CY+ CG+C + +I AL Q +H SCF CV C +
Sbjct: 217 QLAGQSFYQKDGRPLCEPCYQDTLE-RCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARC 275
Query: 512 IRNNVFHL-EDGEPYCETDYYALFGTICHGCEFPI---EAGDMF-LEALGYTWHDTCFVC 566
I + F L E YC D+Y F +C CE PI + D F +E +G +H+ C+ C
Sbjct: 276 IGDESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRC 335
Query: 567 SVC 569
C
Sbjct: 336 EDC 338
Score = 58.5 bits (140), Expect = 2e-08
Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 5/102 (4%)
Query: 479 CGRCQRKILGE--VISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536
C C + + + A+K+ +H CF C C + + F+ +DG P CE Y
Sbjct: 183 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLER 242
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTF 578
C C + D + ALG +H +CF C C + ++F
Sbjct: 243 -CGKCGEVVR--DHIIRALGQAFHPSCFTCVTCARCIGDESF 281
Score = 46.2 bits (108), Expect = 8e-05
Identities = 18/52 (34%), Positives = 28/52 (53%)
Query: 537 ICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588
IC C + ++ +EA+ +H CF C C L GQ+F+ K +PLC+
Sbjct: 182 ICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCE 233
>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 105 bits (262), Expect = 1e-22
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G SWH F C C+ + F+ + +C CYEK A +C +C++ I ++ +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIE--AGDMFLE 553
Q WH CFVC AC K + F D YC + L+ C GC PI G ++
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238
Query: 554 ALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH+ CF C C SL G+ F +++D LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 94.0 bits (232), Expect = 4e-19
Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 437 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL--GEVISAL 494
+ WH F+C+ C+N++ F ++ L C CY ++ +C C++ I+ +
Sbjct: 59 RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118
Query: 495 KQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEA 554
+WH +CF+C C +PI F +D + +C Y C C+ PI G +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 555 LGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH CFVC+ C + L GQ F ++ D C
Sbjct: 179 --QPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Score = 87.0 bits (214), Expect = 4e-17
Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 7/157 (4%)
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV--ISALKQTWH 499
E F+C HC ++ ++ + + YC +C+E FA C C + I + +S + WH
Sbjct: 3 ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62
Query: 500 VSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 559
+CF C C + + F ++ + C Y + + C C+ I G +E G +W
Sbjct: 63 EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122
Query: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLC-----KKHA 591
H+TCF+C C + + ++F K ++ C K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/111 (26%), Positives = 43/111 (38%), Gaps = 4/111 (3%)
Query: 420 CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPEC 479
C C + I + + WH E F C C+ ++ F YC C+ +A +C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221
Query: 480 GRCQRKILG----EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 526
C I G + IS ++ WH CF C C + F E + C
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 13/66 (19%)
Query: 420 CAHCNQVIRG----PFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
CA C I G ++ + WH + FNC C ++ GF+ E+ + C
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC-------- 272
Query: 476 APECGR 481
P+CG+
Sbjct: 273 -PDCGK 277
>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 105 bits (262), Expect = 1e-22
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G SWH F C C+ + F+ + +C CYEK A +C +C++ I ++ +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIE--AGDMFLE 553
Q WH CFVC AC K + F D YC + L+ C GC PI G ++
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238
Query: 554 ALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH+ CF C C SL G+ F +++D LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 94.0 bits (232), Expect = 4e-19
Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 437 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL--GEVISAL 494
+ WH F+C+ C+N++ F ++ L C CY ++ +C C++ I+ +
Sbjct: 59 RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118
Query: 495 KQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEA 554
+WH +CF+C C +PI F +D + +C Y C C+ PI G +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 555 LGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH CFVC+ C + L GQ F ++ D C
Sbjct: 179 --QPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Score = 87.0 bits (214), Expect = 4e-17
Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 7/157 (4%)
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV--ISALKQTWH 499
E F+C HC ++ ++ + + YC +C+E FA C C + I + +S + WH
Sbjct: 3 ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62
Query: 500 VSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 559
+CF C C + + F ++ + C Y + + C C+ I G +E G +W
Sbjct: 63 EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122
Query: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLC-----KKHA 591
H+TCF+C C + + ++F K ++ C K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/111 (26%), Positives = 43/111 (38%), Gaps = 4/111 (3%)
Query: 420 CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPEC 479
C C + I + + WH E F C C+ ++ F YC C+ +A +C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221
Query: 480 GRCQRKILG----EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 526
C I G + IS ++ WH CF C C + F E + C
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 13/66 (19%)
Query: 420 CAHCNQVIRG----PFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
CA C I G ++ + WH + FNC C ++ GF+ E+ + C
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC-------- 272
Query: 476 APECGR 481
P+CG+
Sbjct: 273 -PDCGK 277
>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 105 bits (262), Expect = 1e-22
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G SWH F C C+ + F+ + +C CYEK A +C +C++ I ++ +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIE--AGDMFLE 553
Q WH CFVC AC K + F D YC + L+ C GC PI G ++
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238
Query: 554 ALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH+ CF C C SL G+ F +++D LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 94.0 bits (232), Expect = 4e-19
Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 437 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL--GEVISAL 494
+ WH F+C+ C+N++ F ++ L C CY ++ +C C++ I+ +
Sbjct: 59 RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118
Query: 495 KQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEA 554
+WH +CF+C C +PI F +D + +C Y C C+ PI G +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 555 LGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH CFVC+ C + L GQ F ++ D C
Sbjct: 179 --QPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Score = 87.0 bits (214), Expect = 4e-17
Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 7/157 (4%)
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV--ISALKQTWH 499
E F+C HC ++ ++ + + YC +C+E FA C C + I + +S + WH
Sbjct: 3 ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62
Query: 500 VSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 559
+CF C C + + F ++ + C Y + + C C+ I G +E G +W
Sbjct: 63 EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122
Query: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLC-----KKHA 591
H+TCF+C C + + ++F K ++ C K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/111 (26%), Positives = 43/111 (38%), Gaps = 4/111 (3%)
Query: 420 CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPEC 479
C C + I + + WH E F C C+ ++ F YC C+ +A +C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221
Query: 480 GRCQRKILG----EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 526
C I G + IS ++ WH CF C C + F E + C
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 13/66 (19%)
Query: 420 CAHCNQVIRG----PFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
CA C I G ++ + WH + FNC C ++ GF+ E+ + C
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC-------- 272
Query: 476 APECGR 481
P+CG+
Sbjct: 273 -PDCGK 277
>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 105 bits (262), Expect = 1e-22
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495
G SWH F C C+ + F+ + +C CYEK A +C +C++ I ++ +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIE--AGDMFLE 553
Q WH CFVC AC K + F D YC + L+ C GC PI G ++
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238
Query: 554 ALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH+ CF C C SL G+ F +++D LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 94.0 bits (232), Expect = 4e-19
Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 437 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL--GEVISAL 494
+ WH F+C+ C+N++ F ++ L C CY ++ +C C++ I+ +
Sbjct: 59 RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118
Query: 495 KQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEA 554
+WH +CF+C C +PI F +D + +C Y C C+ PI G +
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178
Query: 555 LGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 587
WH CFVC+ C + L GQ F ++ D C
Sbjct: 179 --QPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Score = 87.0 bits (214), Expect = 4e-17
Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 7/157 (4%)
Query: 442 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV--ISALKQTWH 499
E F+C HC ++ ++ + + YC +C+E FA C C + I + +S + WH
Sbjct: 3 ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62
Query: 500 VSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 559
+CF C C + + F ++ + C Y + + C C+ I G +E G +W
Sbjct: 63 EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122
Query: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLC-----KKHA 591
H+TCF+C C + + ++F K ++ C K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/111 (26%), Positives = 43/111 (38%), Gaps = 4/111 (3%)
Query: 420 CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPEC 479
C C + I + + WH E F C C+ ++ F YC C+ +A +C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221
Query: 480 GRCQRKILG----EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 526
C I G + IS ++ WH CF C C + F E + C
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 13/66 (19%)
Query: 420 CAHCNQVIRG----PFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475
CA C I G ++ + WH + FNC C ++ GF+ E+ + C
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC-------- 272
Query: 476 APECGR 481
P+CG+
Sbjct: 273 -PDCGK 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,904,636
Number of Sequences: 37866
Number of extensions: 1392876
Number of successful extensions: 9003
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 242
Number of HSP's successfully gapped in prelim test: 493
Number of HSP's that attempted gapping in prelim test: 5676
Number of HSP's gapped (non-prelim): 2333
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.