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Search of human proteins with 196115290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 827 0.0
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 746 0.0
gi|62414289 vimentin [Homo sapiens] 454 e-128
gi|55749932 desmin [Homo sapiens] 444 e-125
gi|21264345 peripherin [Homo sapiens] 409 e-114
gi|14249342 internexin neuronal intermediate filament protein, a... 335 6e-92
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 318 8e-87
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 313 1e-85
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 266 4e-71
gi|67782365 keratin 7 [Homo sapiens] 230 2e-60
gi|4504919 keratin 8 [Homo sapiens] 229 5e-60
gi|153791158 keratin 75 [Homo sapiens] 218 6e-57
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 214 9e-56
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap... 214 9e-56
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap... 214 9e-56
gi|14318422 keratin 86 [Homo sapiens] 214 9e-56
gi|119395754 keratin 5 [Homo sapiens] 214 1e-55
gi|169790841 keratin 83 [Homo sapiens] 213 3e-55
gi|169790853 keratin, hair, basic, 1 [Homo sapiens] 211 8e-55
gi|155969697 keratin 6C [Homo sapiens] 211 1e-54
gi|15431310 keratin 14 [Homo sapiens] 210 2e-54
gi|119395750 keratin 1 [Homo sapiens] 210 2e-54
gi|119703753 keratin 6B [Homo sapiens] 209 3e-54
gi|4504935 keratin 85 [Homo sapiens] 209 5e-54
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 208 7e-54
gi|4557701 keratin 17 [Homo sapiens] 207 1e-53
gi|5031839 keratin 6A [Homo sapiens] 207 2e-53
gi|109148552 keratin 3 [Homo sapiens] 207 2e-53
gi|153791670 keratin 76 [Homo sapiens] 206 4e-53
gi|109255249 keratin 4 [Homo sapiens] 204 2e-52
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 827 bits (2137), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA 60
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
Sbjct: 1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA 60
Query: 61 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL 120
GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
Sbjct: 61 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL 120
Query: 121 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT 180
RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
Sbjct: 121 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT 180
Query: 181 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT 240
LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
Sbjct: 181 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT 240
Query: 241 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR 300
QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
Sbjct: 241 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR 300
Query: 301 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD 360
GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
Sbjct: 301 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD 360
Query: 361 IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH 420
IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH
Sbjct: 361 IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH 420
Query: 421 QIVNGTPPARG 431
QIVNGTPPARG
Sbjct: 421 QIVNGTPPARG 431
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 746 bits (1925), Expect = 0.0
Identities = 391/423 (92%), Positives = 407/423 (96%), Gaps = 2/423 (0%)
Query: 1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA 60
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
Sbjct: 1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA 60
Query: 61 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL 120
GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
Sbjct: 61 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL 120
Query: 121 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT 180
RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
Sbjct: 121 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT 180
Query: 181 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT 240
LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
Sbjct: 181 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT 240
Query: 241 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR 300
QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
Sbjct: 241 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR 300
Query: 301 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD 360
GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
Sbjct: 301 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD 360
Query: 361 IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH 420
IEIATYRKLLEGEENRITIPVQTFSNLQIR +++ D ++ +++ ++ + ++
Sbjct: 361 IEIATYRKLLEGEENRITIPVQTFSNLQIR--ETSLDTKSVSEGHLKRNIVVKTVEMRDG 418
Query: 421 QIV 423
+++
Sbjct: 419 EVI 421
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 454 bits (1167), Expect = e-128
Identities = 235/422 (55%), Positives = 319/422 (75%), Gaps = 13/422 (3%)
Query: 8 SAARRSYVSSGEMMVGGLAPGRRLG---PGTRLSLARMPPPLPTRVDFSLAGALNAGFKE 64
S +R Y SS + + RL PG RL L VDFSLA A+N FK
Sbjct: 47 STSRSLYASSPGGVYATRSSAVRLRSSVPGVRL--------LQDSVDFSLADAINTEFKN 98
Query: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELR 124
TR +E+ E+ ELNDRFA+YI+KVRFLEQQNK L AEL QL+ + ++L D+Y+ E+RELR
Sbjct: 99 TRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELR 158
Query: 125 LRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARL 184
++DQLT + AR+EVERDNLA+D+ +R+KLQ+E R EAEN L ++RQ+ D A+LARL
Sbjct: 159 RQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARL 218
Query: 185 DLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEA 244
DLERK+ESL+EEI FL+K+HEEE++ELQ Q+ Q V +++DV+KPDLTAAL+++R QYE+
Sbjct: 219 DLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYES 278
Query: 245 MASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNE 304
+A+ N+ EAEEWY+SKFADL++AA RN + LRQAK E+ +YRRQ+QSLTC++++L+GTNE
Sbjct: 279 VAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNE 338
Query: 305 SLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIA 364
SLERQMRE EE EAA+YQ+ + RL++E Q++K+EMARHL+EYQDLLNVK+ALDIEIA
Sbjct: 339 SLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIA 398
Query: 365 TYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVN 424
TYRKLLEGEE+RI++P+ FS+L +R ++ D T ++L I+ + + Q++N
Sbjct: 399 TYRKLLEGEESRISLPLPNFSSLNLR--ETNLDSLPLVDTHSKRTLLIKTVETRDGQVIN 456
Query: 425 GT 426
T
Sbjct: 457 ET 458
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 444 bits (1141), Expect = e-125
Identities = 236/421 (56%), Positives = 309/421 (73%), Gaps = 10/421 (2%)
Query: 7 TSAARRSY-VSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTR--VDFSLAGALNAGFK 63
+S R Y VS GGL R +RL R P +DFSLA A+N F
Sbjct: 47 SSVTSRVYQVSRTSGGAGGLGSLR----ASRLGTTRTPSSYGAGELLDFSLADAVNQEFL 102
Query: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELREL 123
TR +E+ E+ ELNDRFA+YIEKVRFLEQQN ALAAE+N+L+ +EPT++A++Y+ ELREL
Sbjct: 103 TTRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEELREL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R +++ LT AR++VERDNL DL ++ KLQ+E L+ EAENNLAA+R + D ATLAR
Sbjct: 163 RRQVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLAR 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYE 243
+DLER+IESL EEI FL+K+HEEE+RELQ QL QQV VE+D++KPDLTAAL++IR QYE
Sbjct: 223 IDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYE 282
Query: 244 AMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTN 303
+A+ N+ EAEEWY+SK +DLT AA +N + LRQAK E +YR Q+QS TC++++L+GTN
Sbjct: 283 TIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTN 342
Query: 304 ESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEI 363
+SL RQMRE E+R EA+ YQ+ +ARLEEE + LKDEMARHL+EYQDLLNVK+ALD+EI
Sbjct: 343 DSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEI 402
Query: 364 ATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIV 423
ATYRKLLEGEE+RI +P+QT+S L R T + K++ I+ I + ++V
Sbjct: 403 ATYRKLLEGEESRINLPIQTYSALNFR---ETSPEQRGSEVHTKKTVMIKTIETRDGEVV 459
Query: 424 N 424
+
Sbjct: 460 S 460
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 409 bits (1050), Expect = e-114
Identities = 219/396 (55%), Positives = 298/396 (75%), Gaps = 10/396 (2%)
Query: 30 RLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRF 89
R G G +L R+P R+DFS+A ALN F TR++E+ E+ ELNDRFA++IEKVRF
Sbjct: 64 RAGAG---ALLRLPSE---RLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRF 117
Query: 90 LEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLA 149
LEQQN AL EL+Q R +EP + + Q ELRELR L+ L R++VERD LA+DLA
Sbjct: 118 LEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLA 177
Query: 150 TVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVR 209
++Q+L++ET R +AE+NL +R++ D+ATL+RL+LERKIESL +EI FL+K+HEEE+R
Sbjct: 178 ALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 237
Query: 210 ELQEQLARQQVH-VELDVA-KPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDA 267
+LQ + QQV VE++ KP+LTAAL++IR QYE++A+ N+ EAEEWY+SK+ADL+DA
Sbjct: 238 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDA 297
Query: 268 AARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEA 327
A RN E LRQAK E N+ RRQ+QSLTC+++ LRGTNE+L RQ+RE EE+ EA YQ
Sbjct: 298 ANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAG 357
Query: 328 LARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
ARLEEE + LK+EMARHL+EYQ+LLNVK+ALDIEIATYRKLLEGEE+RI++PV +F++L
Sbjct: 358 AARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASL 417
Query: 388 QIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIV 423
I+ + + E + + K++ I+ I + ++V
Sbjct: 418 NIK--TTVPEVEPPQDSHSRKTVLIKTIETRNGEVV 451
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 335 bits (858), Expect = 6e-92
Identities = 179/356 (50%), Positives = 253/356 (71%), Gaps = 5/356 (1%)
Query: 37 LSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKA 96
L LA PP +D S A A +K R +E+ ++ LNDRFA +IEKV LE QN+A
Sbjct: 62 LGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRA 121
Query: 97 LAAELNQLRAK--EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQK 154
L AEL LR + EP+++ +++Q ELR+LR +L++ ++ ++ +ERD LA+++ +R +
Sbjct: 122 LEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRAR 181
Query: 155 LQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQ 214
++E+ R AE L A +++ D ATLARLDLE+K+ESL +E+ F+R++H+EEV EL
Sbjct: 182 CEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLAT 241
Query: 215 L-ARQQVHVELDV--AKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARN 271
L A Q E+DV AKPDLT+AL+EIR QYE++A+ N+ AEEWY+SKFA+L + AAR+
Sbjct: 242 LQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARS 301
Query: 272 AELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARL 331
E +R ++ E ++YRRQLQ+ T ++E LRG NESLERQ+ E EERH E A YQ+++ +L
Sbjct: 302 TEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQL 361
Query: 332 EEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
E + ++ K EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R + + S L
Sbjct: 362 ENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGL 417
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 318 bits (814), Expect = 8e-87
Identities = 171/373 (45%), Positives = 250/373 (67%), Gaps = 7/373 (1%)
Query: 8 SAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRA 67
S AR +Y S + L+ R S + P L +D S A++ K R
Sbjct: 34 STARSAYSSYSAPVSSSLSVRRSYSS----SSGSLMPSLEN-LDLSQVAAISNDLKSIRT 88
Query: 68 SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKLADVYQAELRELRL 125
E+A++ +LNDRFAS+IE+V LEQQNK L AEL LR K EP++ +Y+ E+R+LRL
Sbjct: 89 QEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRL 148
Query: 126 RLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLD 185
+ T L+ ER+ L + L ++ + ++E R +AE L R+ ADEA LAR +
Sbjct: 149 AAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAE 208
Query: 186 LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245
LE++I+SL +EI FL+K+HEEE+ ELQ Q+ Q+ VE+DV KPDL+AALK+IR QYE +
Sbjct: 209 LEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKL 268
Query: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305
A+ NM AEEW++S+F LT++AA+N + +R AK E ++ RR L++ T ++E+ RG NE+
Sbjct: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEA 328
Query: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365
LE+Q++E E++ + ++ Q+ + +LE E ++ K EMAR+L+EYQDLLNVK+ALDIEIA
Sbjct: 329 LEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAA 388
Query: 366 YRKLLEGEENRIT 378
YRKLLEGEE R++
Sbjct: 389 YRKLLEGEETRLS 401
Score = 33.9 bits (76), Expect = 0.29
Identities = 62/310 (20%), Positives = 131/310 (42%), Gaps = 52/310 (16%)
Query: 75 ELNDRFASYIEKVRFLEQQNKALAAELN-QLRAKEPTKLADVYQ----AELRELRLRLDQ 129
EL R S ++++ FL++ ++ AEL Q++ + + DV + A L+++R + ++
Sbjct: 208 ELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEK 267
Query: 130 LTANS---------ARLEVERDNLAQDLATVR---------QKLQDETNLRLEA----EN 167
L A + +R V ++ A++ VR ++L L +EA
Sbjct: 268 LAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNE 327
Query: 168 NLAAYRQEADEATLARLD-LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDV 226
L QE ++ A + ++ I LE E+R + ++E Q+ L ++ +++++
Sbjct: 328 ALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQD-LLNVKMALDIEI 386
Query: 227 AKPDLTAALKEIR---TQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEAN 283
A +E R T ++ S ++ + RS + L + + L + +
Sbjct: 387 AAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL-----QTSSYLMSTRSFPS 441
Query: 284 DYRRQLQSLTCDLESLRGTNES------------LERQMREQEERHVREAASYQEALARL 331
Y +Q ++E ++ E + +++EE EAA +EA
Sbjct: 442 YYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEA---A 498
Query: 332 EEEGQSLKDE 341
+EE + K+E
Sbjct: 499 KEESEEAKEE 508
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 313 bits (803), Expect = 1e-85
Identities = 160/339 (47%), Positives = 240/339 (70%), Gaps = 10/339 (2%)
Query: 50 VDFSLAGALNAG-------FKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELN 102
+DFS + +L G +K +R++E+ ++ LNDRFA YIEKV +LEQQNK + AE+
Sbjct: 75 LDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQ 134
Query: 103 QLRAKEPT--KLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETN 160
LR K+ + +L D Y E+RELR L+ + A+++++ D+L +D+ ++++ ++E
Sbjct: 135 ALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194
Query: 161 LRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQV 220
LR + E + A R++ +EA+L +++L++K++SL++E+ FLR HEEEV +L Q+ +
Sbjct: 195 LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHI 254
Query: 221 HVEL-DVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAK 279
VE D K D++ ALKEIR+Q E+ + NMH+AEEW++ ++A LT+AA +N E +R AK
Sbjct: 255 TVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAK 314
Query: 280 HEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLK 339
E +YRRQLQS + +LES+RGT ESLERQ+ + EERH + +SYQ+ + +LE E + K
Sbjct: 315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374
Query: 340 DEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRIT 378
EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R +
Sbjct: 375 WEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS 413
Score = 38.9 bits (89), Expect = 0.009
Identities = 59/306 (19%), Positives = 127/306 (41%), Gaps = 32/306 (10%)
Query: 66 RASERAEMMELN-DRFASYIEKVRFLEQQNKALAAELNQLRAKEPT---KLADVYQAELR 121
R ++ E E N + S E++ +Q ++ + EL +R + + +L+D+ +
Sbjct: 295 RYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNH 354
Query: 122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQ--EADEA 179
+L D + +LE E ++A ++ QD N+++ + +AAYR+ E +E
Sbjct: 355 DLSSYQDTIQ----QLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEET 410
Query: 180 TLAR---------------LDLERKIESLEEEIRFLRKIH---EEEVRELQEQLARQQVH 221
+ + + KI+ + E L+ H EE + E + + + ++
Sbjct: 411 RFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEME 470
Query: 222 VELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAA--ARNAELLRQAK 279
L +L ++KE + + EE +K + + A + E ++ +
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 280 HEANDYRRQLQSLTCDLESLRGTNE--SLERQMREQEERHVREAASYQEALARLEEEGQS 337
+ + + D G+ + S E++ EQEE A +EA A+ E++ +
Sbjct: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 338 LKDEMA 343
+E+A
Sbjct: 591 KSEEVA 596
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 266 bits (679), Expect = 4e-71
Identities = 151/321 (47%), Positives = 216/321 (67%), Gaps = 8/321 (2%)
Query: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLA--DVYQAELRE 122
T SE+ ++ LNDRFA YI+KVR LE N++L E LR ++ + A ++Y+ E+RE
Sbjct: 93 TSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVRE 152
Query: 123 LRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLA 182
+R + +L A +L +E+++L +D+A VRQ+L DE R EAE A + A EA A
Sbjct: 153 MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAA 212
Query: 183 RLDLERKIESLEEEIRFLRKIHEEEVRELQEQL-----ARQQVHVEL-DVAKPDLTAALK 236
R+DL++K ++L+EE +LR+ H+EEV EL Q+ A+ Q+ E D K D+T+AL+
Sbjct: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
Query: 237 EIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDL 296
EIR Q E A + ++EEW+R + L++AA N + +R A+ E +YRRQLQ+ T +L
Sbjct: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
Query: 297 ESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVK 356
E+L+ T +SLERQ E E+RH + ASYQEA+ +L+ E ++ K EMA L+EYQDLLNVK
Sbjct: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
Query: 357 LALDIEIATYRKLLEGEENRI 377
+ALDIEIA YRKLLEGEE RI
Sbjct: 393 MALDIEIAAYRKLLEGEECRI 413
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 230 bits (586), Expect = 2e-60
Identities = 135/383 (35%), Positives = 222/383 (57%), Gaps = 19/383 (4%)
Query: 26 APGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIE 85
A G +G G R P R+D + + R E ++ LN++FAS+I+
Sbjct: 54 AYGGPVGAGIREVTINQSLLAPLRLD------ADPSLQRVRQEESEQIKTLNNKFASFID 107
Query: 86 KVRFLEQQNKALAAE---LNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERD 142
KVRFLEQQNK L + L + ++ + ++L D+++A++ LR +L+ L + RLE E
Sbjct: 108 KVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELR 167
Query: 143 NLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRK 202
++ + + K +DE N R AEN +++ D A +++++LE K+++L +EI FLR
Sbjct: 168 SMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRT 227
Query: 203 IHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEAMASSNMHEAEEWYRSKF 261
++E E+ ELQ Q++ V + +D ++ DL + E++ QYE MA + EAE WY++KF
Sbjct: 228 LNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKF 287
Query: 262 ADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERH---V 318
L A ++ + LR ++E ++ R +Q L ++++++ LE + E EER +
Sbjct: 288 ETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELAL 347
Query: 319 REAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRIT 378
++A + QE L + G K +MAR L+EYQ+L++VKLALDIEIATYRKLLEGEE+R+
Sbjct: 348 KDARAKQEELEAALQRG---KQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLA 404
Query: 379 ---IPVQTFSNLQIRGGKSTKDG 398
+ S + GG S+ G
Sbjct: 405 GDGVGAVNISVMNSTGGSSSGGG 427
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 229 bits (583), Expect = 5e-60
Identities = 122/331 (36%), Positives = 204/331 (61%), Gaps = 3/331 (0%)
Query: 58 LNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTK--LADV 115
++ + R E+ ++ LN++FAS+I+KVRFLEQQNK L + + L+ ++ + + ++
Sbjct: 80 VDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNM 139
Query: 116 YQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQE 175
+++ + LR +L+ L +LE E N+ + + K +DE N R E EN +++
Sbjct: 140 FESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKD 199
Query: 176 ADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAA 234
DEA + +++LE ++E L +EI FLR+++EEE+RELQ Q++ V + +D ++ D+ +
Sbjct: 200 VDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSI 259
Query: 235 LKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTC 294
+ E++ QYE +A+ + EAE Y+ K+ +L A ++ + LR+ K E ++ R + L
Sbjct: 260 IAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQA 319
Query: 295 DLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLN 354
++E L+G SLE + + E+R L+ LE Q K +MAR L+EYQ+L+N
Sbjct: 320 EIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMN 379
Query: 355 VKLALDIEIATYRKLLEGEENRITIPVQTFS 385
VKLALDIEIATYRKLLEGEE+R+ +Q S
Sbjct: 380 VKLALDIEIATYRKLLEGEESRLESGMQNMS 410
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 218 bits (556), Expect = 6e-57
Identities = 120/321 (37%), Positives = 193/321 (60%), Gaps = 5/321 (1%)
Query: 63 KETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPT----KLADVYQA 118
+ RA ER ++ LN++FAS+I+KVRFLEQQNK L + L+ + L ++ +
Sbjct: 143 QRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDS 202
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
ELR +L+ +T RLE E N+ + + + +DE N R AEN A +++ D
Sbjct: 203 YTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDA 262
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A + +++LE K++SL EEI F+ + + E+ +LQ Q+ V + +D + DL + + E
Sbjct: 263 AYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAE 322
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
++ QYE +A+ + EAE WY++K+ +L A R+ + LR K E ++ R +Q L +++
Sbjct: 323 VKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEID 382
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
S++ SL+ + + E+R + L LEE Q K +MAR L+EYQ+L+N+KL
Sbjct: 383 SVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKL 442
Query: 358 ALDIEIATYRKLLEGEENRIT 378
ALD+EIATYRKLLEGEE R++
Sbjct: 443 ALDVEIATYRKLLEGEECRLS 463
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 214 bits (546), Expect = 9e-56
Identities = 118/315 (37%), Positives = 193/315 (61%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L +++ + L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E +LR AEN A +++ D A L +
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+R LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ + + + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 403 IATYRRLLEGEEQRL 417
>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 486
Score = 214 bits (546), Expect = 9e-56
Identities = 118/315 (37%), Positives = 193/315 (61%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L +++ + L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E +LR AEN A +++ D A L +
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+R LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ + + + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 403 IATYRRLLEGEEQRL 417
>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
sapiens]
Length = 486
Score = 214 bits (546), Expect = 9e-56
Identities = 118/315 (37%), Positives = 193/315 (61%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L +++ + L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E +LR AEN A +++ D A L +
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+R LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ + + + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 403 IATYRRLLEGEEQRL 417
>gi|14318422 keratin 86 [Homo sapiens]
Length = 486
Score = 214 bits (546), Expect = 9e-56
Identities = 118/315 (37%), Positives = 193/315 (61%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L +++ + L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E +LR AEN A +++ D A L +
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+R LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ + + + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 403 IATYRRLLEGEEQRL 417
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 214 bits (545), Expect = 1e-55
Identities = 115/327 (35%), Positives = 196/327 (59%), Gaps = 7/327 (2%)
Query: 58 LNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTK-----L 112
++ + R ER ++ LN++FAS+I+KVRFLEQQNK L + L+ ++ TK L
Sbjct: 157 IDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQ-EQGTKTVRQNL 215
Query: 113 ADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAY 172
+++ + LR +LD + RL+ E N+ + + K +DE N R AEN
Sbjct: 216 EPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVML 275
Query: 173 RQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DL 231
+++ D A + +++LE K+++L +EI F++ + E+ ++Q ++ V + +D + DL
Sbjct: 276 KKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDL 335
Query: 232 TAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQS 291
+ + E++ QYE +A+ + EAE WY++K+ +L A R+ + LR KHE ++ R +Q
Sbjct: 336 DSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQR 395
Query: 292 LTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQD 351
L ++++++ +L+ + + E+R + LA LEE Q K +MAR L+EYQ+
Sbjct: 396 LRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQE 455
Query: 352 LLNVKLALDIEIATYRKLLEGEENRIT 378
L+N KLALD+EIATYRKLLEGEE R++
Sbjct: 456 LMNTKLALDVEIATYRKLLEGEECRLS 482
>gi|169790841 keratin 83 [Homo sapiens]
Length = 493
Score = 213 bits (542), Expect = 3e-55
Identities = 119/315 (37%), Positives = 192/315 (60%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L ++ + L
Sbjct: 108 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGYIETL 167
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E LR AEN A +++ D A L +
Sbjct: 168 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRK 227
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+R LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 228 SDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIVAEIKAQY 287
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ +A+ + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 288 DDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 347
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 348 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 407
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 408 IATYRRLLEGEEQRL 422
>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
Length = 505
Score = 211 bits (538), Expect = 8e-55
Identities = 117/315 (37%), Positives = 192/315 (60%), Gaps = 3/315 (0%)
Query: 66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELREL 123
+ E+ ++ LN RFA++I+KVRFLEQQNK L +L + +E + L +++ + L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLAR 183
R + + A+S RL E +++ + L ++K ++E +LR AEN A +++ D A L +
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 184 LDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQY 242
DLE +E+L +EI FLR+++EEE+ LQ ++ V V+LD ++ ++ + EI+ QY
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGT 302
+ + + + EAE WYRSK ++ R+ E LR+ K E N+ R +Q LT ++E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 303 NESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIE 362
N LE + + E++ + + LA LE Q K +MA ++EYQ+++N KL LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 363 IATYRKLLEGEENRI 377
IATYR+LLEGEE R+
Sbjct: 403 IATYRRLLEGEEQRL 417
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 211 bits (536), Expect = 1e-54
Identities = 131/380 (34%), Positives = 210/380 (55%), Gaps = 20/380 (5%)
Query: 17 SGEMMVGGLAPGRRLGPGTRLSLARMPPPLPT---------RVDFSLAGALNA----GFK 63
SG GG G LG G L+ P P V+ SL LN +
Sbjct: 98 SGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQ 157
Query: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTK-----LADVYQA 118
RA ER ++ LN++FAS+I+KVRFLEQQNK L + L+ ++ TK L +++
Sbjct: 158 RVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQ-EQGTKTVRQNLEPLFEQ 216
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
+ LR +LD + RL+ E N+ + ++ K +DE N R AEN +++ D
Sbjct: 217 YINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A + +++L+ K ++L +EI FLR +++ E+ ++Q ++ V + +D + DL + + E
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAE 336
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
++ QYE +A + EAE WY++K+ +L A R+ + LR K E + R +Q L +++
Sbjct: 337 VKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEID 396
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
++ SL+ + + E+R + L LE+ Q K ++AR L+EYQ+L+NVKL
Sbjct: 397 HVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKL 456
Query: 358 ALDIEIATYRKLLEGEENRI 377
ALD+EIATYRKLLEGEE R+
Sbjct: 457 ALDVEIATYRKLLEGEECRL 476
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 210 bits (535), Expect = 2e-54
Identities = 131/361 (36%), Positives = 208/361 (57%), Gaps = 16/361 (4%)
Query: 68 SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQ-LRAKEPTKLADV--YQAELRELR 124
SE+ M LNDR ASY++KVR LE+ N L ++ + + P ++ D Y + +LR
Sbjct: 114 SEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLR 173
Query: 125 LRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARL 184
++ T ++A + ++ DN R K + E NLR+ E ++ R+ DE TLAR
Sbjct: 174 NKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARA 233
Query: 185 DLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYE 243
DLE +IESL+EE+ +L+K HEEE+ L+ Q+ V+VE+D A DL+ L E+R QYE
Sbjct: 234 DLEMQIESLKEELAYLKKNHEEEMNALRGQVGGD-VNVEMDAAPGVDLSRILNEMRDQYE 292
Query: 244 AMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTN 303
MA N +AEEW+ +K +L A N+EL++ K E ++ RR +Q+L +L+S
Sbjct: 293 KMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMK 352
Query: 304 ESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEI 363
SLE + E + R+ + A QE + +EE+ L+ EM + QEY+ LL+VK L+ EI
Sbjct: 353 ASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEI 412
Query: 364 ATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIV 423
ATYR+LLEGE+ ++ S+ G +S++D VT + + +V+ + ++V
Sbjct: 413 ATYRRLLEGEDAHLS------SSQFSSGSQSSRD-----VTSSSRQIRTKVMDVHDGKVV 461
Query: 424 N 424
+
Sbjct: 462 S 462
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 210 bits (534), Expect = 2e-54
Identities = 117/349 (33%), Positives = 210/349 (60%), Gaps = 14/349 (4%)
Query: 63 KETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPT----KLADVYQA 118
++ ++ ER ++ LN++FAS+I+KVRFLEQQN+ L + L+ + + L +++
Sbjct: 174 QKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFES 233
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
+ LR R+DQL ++ +RL+ E N+ + R K +DE N R AEN +++ D
Sbjct: 234 FINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDG 293
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A + ++DL+ K+++L++EI FL +++ E+ ++Q Q++ V + +D + DL + + E
Sbjct: 294 AYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAE 353
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
++ QYE +A + EAE Y+SK+ +L A R+ + +R +K E ++ R +Q L +++
Sbjct: 354 VKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEID 413
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
+++ +L++ + + E+R + L LE+ Q K+++AR L++YQ+L+N KL
Sbjct: 414 NVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKL 473
Query: 358 ALDIEIATYRKLLEGEENR--------ITIPVQTFSNLQIRGGKSTKDG 398
ALD+EIATYR LLEGEE+R +++ V T S+ I GG S G
Sbjct: 474 ALDLEIATYRTLLEGEESRMSGECAPNVSVSVST-SHTTISGGGSRGGG 521
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 209 bits (533), Expect = 3e-54
Identities = 130/380 (34%), Positives = 210/380 (55%), Gaps = 20/380 (5%)
Query: 17 SGEMMVGGLAPGRRLGPGTRLSLARMPPPLPT---------RVDFSLAGALNA----GFK 63
SG GG G LG G L+ P P V+ SL LN +
Sbjct: 98 SGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQ 157
Query: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTK-----LADVYQA 118
RA ER ++ LN++FAS+I+KVRFLEQQNK L + L+ ++ TK L +++
Sbjct: 158 RVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQ-EQGTKTVRQNLEPLFEQ 216
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
+ LR +LD + RL+ E N+ + ++ K +DE N R AEN +++ D
Sbjct: 217 YINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A + +++L+ K ++L +EI FLR +++ E+ ++Q ++ V + +D + DL + + E
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAE 336
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
++ QYE +A + EAE WY++K+ +L A R+ + LR K E + R +Q L +++
Sbjct: 337 VKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEID 396
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
++ +L+ + + E+R + L LE+ Q K ++AR L+EYQ+L+NVKL
Sbjct: 397 HVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKL 456
Query: 358 ALDIEIATYRKLLEGEENRI 377
ALD+EIATYRKLLEGEE R+
Sbjct: 457 ALDVEIATYRKLLEGEECRL 476
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 209 bits (531), Expect = 5e-54
Identities = 136/389 (34%), Positives = 213/389 (54%), Gaps = 15/389 (3%)
Query: 4 RRITSAARRSYVSSGE----MMVGGLAPG---RRLGPGTRLSLARMPPPLPT-RVDFSLA 55
R +T RS + G + VGG G R G + PP + T V+ SL
Sbjct: 46 RGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLL 105
Query: 56 GALNAGFKET----RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE--P 109
LN + E+ ++ LN RFA++I+KVRFLEQQNK L + + +
Sbjct: 106 TPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCE 165
Query: 110 TKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNL 169
+ L ++ + LR + + A+S RL E +++ + L ++K ++E LR AEN
Sbjct: 166 SNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEF 225
Query: 170 AAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP 229
+++ D A L + DLE +E+L EE FLR+++EEE+R LQ ++ V V++D ++
Sbjct: 226 VVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRD 285
Query: 230 -DLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQ 288
++ + EI+ QY+ +AS + EAE WYRSK ++ R+ E LR+ K E N+ R
Sbjct: 286 LNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRM 345
Query: 289 LQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQE 348
+Q LT ++E+ + LE + E E++ + + LA LE Q K +MA L+E
Sbjct: 346 IQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKE 405
Query: 349 YQDLLNVKLALDIEIATYRKLLEGEENRI 377
YQ+++N KL LDIEIATYR+LLEGEE+R+
Sbjct: 406 YQEVMNSKLGLDIEIATYRRLLEGEEHRL 434
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 208 bits (530), Expect = 7e-54
Identities = 123/362 (33%), Positives = 211/362 (58%), Gaps = 10/362 (2%)
Query: 23 GGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGF----KETRASERAEMMELND 78
GG G R+G + + P V+ SL LN + + E+ ++ LN+
Sbjct: 118 GGPGFGYRVGG---VGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNN 174
Query: 79 RFASYIEKVRFLEQQNKALAAELNQLRAKE--PTKLADVYQAELRELRLRLDQLTANSAR 136
+FAS+I+KVRFLEQQNK L + + L+ ++ + L ++++ + LR +L+ L ++ AR
Sbjct: 175 KFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVSDQAR 234
Query: 137 LEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEE 196
L+ ER++L L ++K ++E R AEN A +++ D A + + DLE +++L +E
Sbjct: 235 LQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNKSDLEANVDTLTQE 294
Query: 197 IRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEAMASSNMHEAEE 255
I FL+ ++ EE++ LQ ++ V V++D ++ +L + E++ QYE +A + +AE
Sbjct: 295 IDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADAEA 354
Query: 256 WYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEE 315
WY++K+ ++ A ++ + LR ++E N+ R +Q L ++E + LE + E E+
Sbjct: 355 WYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAVAEAEQ 414
Query: 316 RHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEEN 375
+ + + LA LE Q K +MAR L EYQ+L+N KL LDIEIATYR+LLEGEE+
Sbjct: 415 QGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLLEGEES 474
Query: 376 RI 377
R+
Sbjct: 475 RL 476
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 207 bits (527), Expect = 1e-53
Identities = 133/365 (36%), Positives = 199/365 (54%), Gaps = 10/365 (2%)
Query: 23 GGLAPGR-RLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKET----RASERAEMMELN 77
GGL G RLG L + F G + F E+A M LN
Sbjct: 33 GGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLN 92
Query: 78 DRFASYIEKVRFLEQQNKALAAELN---QLRAKEPTKLADVYQAELRELRLRLDQLTANS 134
DR ASY++KVR LE+ N L ++ Q +A P + Y + EL+ ++ T ++
Sbjct: 93 DRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDN 152
Query: 135 ARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194
A + ++ DN R K + E LRL E ++ R+ DE TLAR DLE +IE+L+
Sbjct: 153 ANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLK 212
Query: 195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEAMASSNMHEA 253
EE+ +L+K HEEE+ L+ Q+ + ++VE+D A DL+ L E+R QYE MA N +A
Sbjct: 213 EELAYLKKNHEEEMNALRGQVGGE-INVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDA 271
Query: 254 EEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQ 313
E+W+ SK +L A N+EL++ K E ++ RR +Q+L +L+S SLE + E
Sbjct: 272 EDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAET 331
Query: 314 EERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGE 373
E R+ + + Q + +EE+ L+ EM + QEY+ LL+VK L+ EIATYR+LLEGE
Sbjct: 332 ENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGE 391
Query: 374 ENRIT 378
+ +T
Sbjct: 392 DAHLT 396
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 207 bits (526), Expect = 2e-53
Identities = 130/380 (34%), Positives = 208/380 (54%), Gaps = 20/380 (5%)
Query: 17 SGEMMVGGLAPGRRLGPGTRLSLARMPPPLPT---------RVDFSLAGALNAGFKET-- 65
SG GG G LG G L+ P P V+ SL LN T
Sbjct: 98 SGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQ 157
Query: 66 --RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTK-----LADVYQA 118
RA ER ++ LN++FAS+I+KVRFLEQQNK L + L+ ++ TK L +++
Sbjct: 158 RVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQ-EQGTKTVRQNLEPLFEQ 216
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
+ LR +LD + RL+ E + + + K +DE N R AEN +++ D
Sbjct: 217 YINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A + +++L+ K ++L +EI FLR +++ E+ ++Q ++ V + +D + DL + + E
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAE 336
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
++ QYE +A + EAE WY++K+ +L A R+ + LR K E + R +Q L +++
Sbjct: 337 VKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEID 396
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
++ +L+ + + E+R + L LE+ Q K ++AR L+EYQ+L+NVKL
Sbjct: 397 HVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKL 456
Query: 358 ALDIEIATYRKLLEGEENRI 377
ALD+EIATYRKLLEGEE R+
Sbjct: 457 ALDVEIATYRKLLEGEECRL 476
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 207 bits (526), Expect = 2e-53
Identities = 120/364 (32%), Positives = 205/364 (56%), Gaps = 16/364 (4%)
Query: 23 GGLAPGRRLGPGTRLSLAR-MPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFA 81
GG PG G +++ + + PL +D + + +A ER ++ LN++FA
Sbjct: 159 GGFGPGGFPGGIQEVTINQSLLQPLNVEIDPQIG--------QVKAQEREQIKTLNNKFA 210
Query: 82 SYIEKVRFLEQQNKALAAELNQLRAKEPTKLAD------VYQAELRELRLRLDQLTANSA 135
S+I+KVRFLEQQNK L + N L+ + + ++ +++ + LR LD +
Sbjct: 211 SFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERG 270
Query: 136 RLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEE 195
RL+ E N+ + ++K +DE N R AEN +++ D A + +++L+ K+++L +
Sbjct: 271 RLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALID 330
Query: 196 EIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEAMASSNMHEAE 254
EI FLR +++ E+ ++Q ++ V + +D + DL + + E+R QYE +A + EAE
Sbjct: 331 EIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAE 390
Query: 255 EWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQE 314
Y++K +L A R+ + LR K E + R +Q L ++E ++ N +L+ + E E
Sbjct: 391 ALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAE 450
Query: 315 ERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEE 374
+ L L+ Q KD++AR L++YQ+L+NVKLALD+EIATYRKLLEGEE
Sbjct: 451 QHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEE 510
Query: 375 NRIT 378
R++
Sbjct: 511 YRMS 514
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 206 bits (523), Expect = 4e-53
Identities = 118/342 (34%), Positives = 196/342 (57%), Gaps = 11/342 (3%)
Query: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKE----PTKLADVYQAE 119
+ +A ER ++ LN++FAS+I+KVRFLEQQNK L + L+ + P+ L +++
Sbjct: 178 QVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESY 237
Query: 120 LRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEA 179
+ L +LD L LE E ++ + ++K +DE N R AEN +++ D A
Sbjct: 238 ISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAA 297
Query: 180 TLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEI 238
+ +++L+ K++SL +E+ FLR ++E E+ ++Q + V + +D + DL + + E+
Sbjct: 298 FMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEV 357
Query: 239 RTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLES 298
R QYE +A + EAE Y++K +L A R+ + LR K E + R +Q L ++E+
Sbjct: 358 RAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIEN 417
Query: 299 LRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLA 358
++ N +L+ + E E+R L L+ Q KD++AR L++YQ+L+NVKLA
Sbjct: 418 VKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLA 477
Query: 359 LDIEIATYRKLLEGEENRIT------IPVQTFSNLQIRGGKS 394
LD+EIATYRKLLEGEE R++ + + SN+ G S
Sbjct: 478 LDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSS 519
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 204 bits (518), Expect = 2e-52
Identities = 115/341 (33%), Positives = 199/341 (58%), Gaps = 5/341 (1%)
Query: 63 KETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPT----KLADVYQA 118
++ R ER ++ LN++FAS+I+KV+FLEQQNK L + N L+ + T L +++
Sbjct: 205 QKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFET 264
Query: 119 ELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADE 178
L LR +LD L + RL+ E + + + K ++E N R AEN+ +++ D
Sbjct: 265 YLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDA 324
Query: 179 ATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKE 237
A L +++LE K++SL +EI FL+ +++ E+ ++Q ++ V + +D + DL + + E
Sbjct: 325 AYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAE 384
Query: 238 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE 297
+R QYE +A + EAE Y++K L + ++ + L+ K E + R +Q L ++E
Sbjct: 385 VRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIE 444
Query: 298 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL 357
+++ ++L+ + + E+R LE Q K+E+AR L+EYQ+L++VKL
Sbjct: 445 NIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKL 504
Query: 358 ALDIEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDG 398
ALDIEIATYRKLLEGEE R++ Q+ ++ + G ++ G
Sbjct: 505 ALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGG 545
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,172,799
Number of Sequences: 37866
Number of extensions: 619329
Number of successful extensions: 8510
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 353
Number of HSP's successfully gapped in prelim test: 780
Number of HSP's that attempted gapping in prelim test: 3608
Number of HSP's gapped (non-prelim): 3087
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.