Search of human proteins with 194328809

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194328809 latent transforming growth factor beta binding
protein 3 isoform 1 [Homo sapiens]
         (1303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194328809 latent transforming growth factor beta binding prot...  2878   0.0  
gi|18497288 latent transforming growth factor beta binding prote...  2747   0.0  
gi|46249414 latent transforming growth factor beta binding prote...   957   0.0  
gi|46249412 latent transforming growth factor beta binding prote...   957   0.0  
gi|4557733 latent transforming growth factor beta binding protei...   789   0.0  
gi|110347437 latent transforming growth factor beta binding prot...   637   0.0  
gi|110347412 latent transforming growth factor beta binding prot...   612   e-175
gi|110347431 latent transforming growth factor beta binding prot...   612   e-175
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      468   e-131
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      428   e-119
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      405   e-112
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               226   1e-58
gi|134244285 Notch homolog 3 [Homo sapiens]                           222   2e-57
gi|148833508 notch1 preproprotein [Homo sapiens]                      220   8e-57
gi|55770876 notch4 preproprotein [Homo sapiens]                       217   5e-56
gi|24041035 notch 2 preproprotein [Homo sapiens]                      217   7e-56
gi|118572606 hemicentin 1 [Homo sapiens]                              217   7e-56
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              209   1e-53
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              202   2e-51
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              202   2e-51
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        201   4e-51
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              200   6e-51
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              200   6e-51
gi|190343004 EGF-containing fibulin-like extracellular matrix pr...   190   9e-48
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     187   4e-47
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               185   2e-46
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               184   6e-46
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    183   1e-45
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             182   2e-45
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             182   2e-45

>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score = 2878 bits (7462), Expect = 0.0
 Identities = 1303/1303 (100%), Positives = 1303/1303 (100%)

Query: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60
            MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
Sbjct: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
Sbjct: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
Sbjct: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240
            SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
Sbjct: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240

Query: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300
            QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
Sbjct: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300

Query: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360
            EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
Sbjct: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420
            MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
Sbjct: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420

Query: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480
            TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
Sbjct: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480

Query: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540
            FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
Sbjct: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540

Query: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
Sbjct: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
Sbjct: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660

Query: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720
            LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
Sbjct: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720

Query: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780
            KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
Sbjct: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840
            RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840

Query: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
            CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
Sbjct: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
            TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
Sbjct: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020
            VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
Sbjct: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
            CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080

Query: 1081 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS 1140
            MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS
Sbjct: 1081 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS 1140

Query: 1141 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200
            QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
Sbjct: 1141 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200

Query: 1201 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260
            PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
Sbjct: 1201 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260

Query: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
            LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303


>gi|18497288 latent transforming growth factor beta binding protein 3
            isoform 2 [Homo sapiens]
          Length = 1256

 Score = 2747 bits (7121), Expect = 0.0
 Identities = 1256/1303 (96%), Positives = 1256/1303 (96%), Gaps = 47/1303 (3%)

Query: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60
            MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
Sbjct: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
Sbjct: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
Sbjct: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240
            SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
Sbjct: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240

Query: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300
            QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
Sbjct: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300

Query: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360
            EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
Sbjct: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420
            MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
Sbjct: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420

Query: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480
            TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
Sbjct: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480

Query: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540
            FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
Sbjct: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540

Query: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
Sbjct: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
Sbjct: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660

Query: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720
            LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
Sbjct: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720

Query: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780
            KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
Sbjct: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840
            RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840

Query: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
            CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
Sbjct: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
            TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
Sbjct: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020
            VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
Sbjct: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
            CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080

Query: 1081 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS 1140
            M                                               ERAPERRDVCWS
Sbjct: 1081 M-----------------------------------------------ERAPERRDVCWS 1093

Query: 1141 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200
            QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
Sbjct: 1094 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1153

Query: 1201 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260
            PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
Sbjct: 1154 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213

Query: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
            LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Sbjct: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  957 bits (2474), Expect = 0.0
 Identities = 545/1462 (37%), Positives = 715/1462 (48%), Gaps = 327/1462 (22%)

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            R KVVF P ICK TC KG C++SC++G+  TLI ENGH+ DTLT + FRVV+C LPCMNG
Sbjct: 351  RIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNG 410

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSR++C CPP+FTG+ CQ+P  GA                    ++P L        
Sbjct: 411  GQCSSRDKCQCPPNFTGKLCQIPVHGA--------------------SVPKLYQHSQQ-- 448

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLG-PGQISAEVQAPPPVVNVRVHHPPEAS 239
                          PG   G    H+   +PL    Q   +V+ PP +VN+ V HPPEAS
Sbjct: 449  --------------PGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEAS 494

Query: 240  VQVHRIESSNAESAAPSQHLLP-HPKPSHPRPPTQKP----------------------- 275
            VQ+H++   +  +   ++   P   + S+   P QK                        
Sbjct: 495  VQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKT 554

Query: 276  -LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
             LGRCFQ+T+  Q CG   LPGL+KQEDCCG++GT+WG +KC KCP+       KP    
Sbjct: 555  QLGRCFQETIGSQ-CGK-ALPGLSKQEDCCGTVGTSWGFNKCQKCPK-------KPSYHG 605

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 +C  GYKR+N+T CQDINEC + GVC +G+CLN  GSYRC C  G    P+ + C
Sbjct: 606  YNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665

Query: 395  IADKP---EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + D P   EEK  C+RLVS   QC HPL+  LT+QLCCCSVGKAWG  C++CP  GTAAF
Sbjct: 666  VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAF 725

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP----PKPQQLPESPSQAPPPEDTE 507
            KEICP G GY +   H+   I             GP    PK  Q P + S  PPP   +
Sbjct: 726  KEICPGGMGYTVSGVHRRRPIHHHVG-------KGPVFVKPKNTQ-PVAKSTHPPPLPAK 777

Query: 508  EER-----------------GVTTDSPVSEERSVQQSH-----------PTATTTPARP- 538
            EE                   V T  P  E  S+ Q             P  +T    P 
Sbjct: 778  EEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQ 837

Query: 539  YPEL-ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDY 597
            +P + I + SPP      P+   S ++  IAPTQVTE +EC +N +ICG G C+  P  Y
Sbjct: 838  FPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRY 897

Query: 598  SCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRS 657
            +C C  GYR   Q R CVD++EC        +G C NT GS+ C C  G+       G +
Sbjct: 898  TCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM--ASEEGTN 955

Query: 658  CVDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            C+D++EC +P +CG+G  C+N  G ++C  C  GYR+  ++   CEDIDEC +PS+CPD 
Sbjct: 956  CIDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDE 1012

Query: 717  KCENKPGSFKCIACQPGYRSQGGGA----------------------------------- 741
            +C N PGS++C+ C  G+R   G                                     
Sbjct: 1013 QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT 1072

Query: 742  -----CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
                 CRD++EC +G+ C  G C+N  GSFRCTC QGY  +     C D+DEC+   +C 
Sbjct: 1073 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 1132

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQG 855
            +G C NT GSFQC C  GY  S    HCEDI+EC +  + C  GDCINT GSY C CP G
Sbjct: 1133 HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG 1192

Query: 856  HRL------------------------------------------VGGRKCQDIDECSQD 873
             +L                                            GR C+DIDEC  +
Sbjct: 1193 FQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNN 1252

Query: 874  PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG------------------CEEVE---- 911
             ++C  HG C N  GS+ C+C +GF   QD  G                  CE VE    
Sbjct: 1253 -TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 1311

Query: 912  ------------------------------QP-HHKKECYLNFDDTVFCDSVLATNVTQQ 940
                                          QP   KKECY N +D   CD+VLA NVT+Q
Sbjct: 1312 CVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ 1371

Query: 941  ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DNNIVNYGIPAHRDIDECML 999
            ECCC+ GAGWGD+CEI+PCPV  +AEF  +CP GKG+     +    G   ++D DEC+L
Sbjct: 1372 ECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLL 1431

Query: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR 1059
            FG EICK G C+NT+PGYECYCKQG YYD   L+C D+DEC D S+C +G C NT G Y 
Sbjct: 1432 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1491

Query: 1060 CACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR 1119
            C CT P     ++++C+ P E +                                     
Sbjct: 1492 CFCTHPMVLDASEKRCIRPAESN------------------------------------- 1514

Query: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPP 1179
                     E     +D+CW    ++ +C+ PL G   T+ +CCC  G  WG QC  CP 
Sbjct: 1515 ------EQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL 1568

Query: 1180 RGA------------GSHCPTSQSESNSFW-----DTSPLLLGKPPRDEDSSEE-DSDEC 1221
            + +            G   P  +     F      +  P  +    R  +S EE  ++EC
Sbjct: 1569 KDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI--QDRFLNSFEELQAEEC 1626

Query: 1222 ----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTS 1277
                 C +GRCV    G  C+C  G+ LD ++  CVD++EC ELN R  LCK+ +C+NT 
Sbjct: 1627 GILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTD 1686

Query: 1278 GSFRCVCKAGFARSRPHGACVP 1299
            GS++C+C  G+  S     C P
Sbjct: 1687 GSYKCLCLPGYVPSDKPNYCTP 1708



 Score =  180 bits (457), Expect = 7e-45
 Identities = 152/575 (26%), Positives = 224/575 (38%), Gaps = 128/575 (22%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGIC 632
            + +EC  ++++C  G+C+     Y C C  G++    ++ C D+NECE    CGP +G C
Sbjct: 1162 DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP-QGEC 1219

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
            +NT GS++C C +G+   + A GR+C D++EC    +C   GFC N  G ++C CY G++
Sbjct: 1220 LNTEGSFHCVCQQGFS--ISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1277

Query: 693  LKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYR-SQGGGACR------- 743
                    C D++EC   S  C +  CEN  GSF C+        S   G CR       
Sbjct: 1278 APQDGQG-CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDL 1336

Query: 744  ---------DVNECA----EGSPCS-----------------PGW---CENLPGSF---- 766
                     +  EC     + S C                   GW   CE  P       
Sbjct: 1337 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTA 1396

Query: 767  ----RCTCAQGYAPAPD------GRSCLDVDECE--AGDVCDNGICSNTPGSFQCQCLSG 814
                 C   +G+ PA +      G +  D DEC     ++C NG C NT   ++C C  G
Sbjct: 1397 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1456

Query: 815  YHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-C-------QD 866
             +    +  C D+DEC  P++CI G C+NT GSY C C     L    K C       + 
Sbjct: 1457 TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQ 1516

Query: 867  IDECSQDPSLCLPHGACKNL--------QGSYV-CVCDEG--------FTPTQDQHGCEE 909
            I+E      LC  H + + +        Q +Y  C C  G          P +D     +
Sbjct: 1517 IEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1576

Query: 910  V--------EQPHHK------KECYLNFDDTVFCDSVLATNVT--QQECCCSLGAGWGDH 953
            +         QP+ +       E Y    D  F       +    Q E C  L       
Sbjct: 1577 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGR 1636

Query: 954  C----EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE--ICKE 1007
            C    E Y C  +             GY  D   +        D++EC    +   +CK 
Sbjct: 1637 CVRVQEGYTCDCFD------------GYHLDTAKMTCV-----DVNECDELNNRMSLCKN 1679

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
             KC+NT   Y+C C  G+        C  ++  L+
Sbjct: 1680 AKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALN 1714



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 80/295 (27%), Positives = 113/295 (38%), Gaps = 55/295 (18%)

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
            G C+NT   Y C+C +G   +       C D++EC  P  C DG  C+N  G Y C C  
Sbjct: 1440 GFCLNTRPGYECYCKQG--TYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYNCFCTH 1496

Query: 690  GYRLKAS-----RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRD 744
               L AS     RP   E  ++  +     D   E+    + C     G ++     C  
Sbjct: 1497 PMVLDASEKRCIRP--AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1554

Query: 745  VNECAEGSPC-------SPGWCE--NLPGSFR---------CTCAQGYAPAPDGRSCLD- 785
              E A G  C       S  + +  N+P + R            ++ Y P  D     D 
Sbjct: 1555 YGE-AWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1613

Query: 786  ---------VDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD----F 832
                      +EC   + C+NG C      + C C  GYHL   +  C D++ECD     
Sbjct: 1614 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1673

Query: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
             + C    CINT+GSY+CLC  G+              S  P+ C P     NL+
Sbjct: 1674 MSLCKNAKCINTDGSYKCLCLPGY------------VPSDKPNYCTPLNTALNLE 1716



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 31/107 (28%), Positives = 40/107 (37%), Gaps = 12/107 (11%)

Query: 113 CPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGT--GGSGPGLSRTGALSTGALP 170
           C  PC NGG C     C+C P   G+ C+  A         GG  P     GA S+   P
Sbjct: 191 CVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSP-----GAASSWGPP 245

Query: 171 PLAPEGDSVASKHAIYAVQVIAD-----PPGPGEGPPAQHAAFLVPL 212
             A +  S      +  V  +A       P P  G P Q  + + PL
Sbjct: 246 EQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPL 292



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 15/47 (31%), Positives = 22/47 (46%)

Query: 572  VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            V E DE     ++C + +C+     Y C C PGY    +  YC  +N
Sbjct: 1664 VNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 36/130 (27%), Positives = 44/130 (33%), Gaps = 30/130 (23%)

Query: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA-----------CQPGYRSQG 738
           G  L+  RPP     +  R   + P G+    PG     A            +    +Q 
Sbjct: 92  GAALQGLRPPPPPPPEPARP--AVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQS 149

Query: 739 GGACR----------DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788
           GG  R           VN C  G  C  GW +  PGS RCT      P  +G  CL    
Sbjct: 150 GGGSRLQVHQKQQLQGVNVC--GGRCCHGWSK-APGSQRCTKPSCVPPCQNGGMCLRPQL 206

Query: 789 CEAGDVCDNG 798
           C    VC  G
Sbjct: 207 C----VCKPG 212


>gi|46249412 latent transforming growth factor beta binding protein 1
            isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  957 bits (2474), Expect = 0.0
 Identities = 545/1462 (37%), Positives = 715/1462 (48%), Gaps = 327/1462 (22%)

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            R KVVF P ICK TC KG C++SC++G+  TLI ENGH+ DTLT + FRVV+C LPCMNG
Sbjct: 25   RIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNG 84

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSR++C CPP+FTG+ CQ+P  GA                    ++P L        
Sbjct: 85   GQCSSRDKCQCPPNFTGKLCQIPVHGA--------------------SVPKLYQHSQQ-- 122

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLG-PGQISAEVQAPPPVVNVRVHHPPEAS 239
                          PG   G    H+   +PL    Q   +V+ PP +VN+ V HPPEAS
Sbjct: 123  --------------PGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEAS 168

Query: 240  VQVHRIESSNAESAAPSQHLLP-HPKPSHPRPPTQKP----------------------- 275
            VQ+H++   +  +   ++   P   + S+   P QK                        
Sbjct: 169  VQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKT 228

Query: 276  -LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
             LGRCFQ+T+  Q CG   LPGL+KQEDCCG++GT+WG +KC KCP+       KP    
Sbjct: 229  QLGRCFQETIGSQ-CGK-ALPGLSKQEDCCGTVGTSWGFNKCQKCPK-------KPSYHG 279

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 +C  GYKR+N+T CQDINEC + GVC +G+CLN  GSYRC C  G    P+ + C
Sbjct: 280  YNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339

Query: 395  IADKP---EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + D P   EEK  C+RLVS   QC HPL+  LT+QLCCCSVGKAWG  C++CP  GTAAF
Sbjct: 340  VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAF 399

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP----PKPQQLPESPSQAPPPEDTE 507
            KEICP G GY +   H+   I             GP    PK  Q P + S  PPP   +
Sbjct: 400  KEICPGGMGYTVSGVHRRRPIHHHVG-------KGPVFVKPKNTQ-PVAKSTHPPPLPAK 451

Query: 508  EER-----------------GVTTDSPVSEERSVQQSH-----------PTATTTPARP- 538
            EE                   V T  P  E  S+ Q             P  +T    P 
Sbjct: 452  EEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQ 511

Query: 539  YPEL-ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDY 597
            +P + I + SPP      P+   S ++  IAPTQVTE +EC +N +ICG G C+  P  Y
Sbjct: 512  FPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRY 571

Query: 598  SCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRS 657
            +C C  GYR   Q R CVD++EC        +G C NT GS+ C C  G+       G +
Sbjct: 572  TCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM--ASEEGTN 629

Query: 658  CVDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            C+D++EC +P +CG+G  C+N  G ++C  C  GYR+  ++   CEDIDEC +PS+CPD 
Sbjct: 630  CIDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDE 686

Query: 717  KCENKPGSFKCIACQPGYRSQGGGA----------------------------------- 741
            +C N PGS++C+ C  G+R   G                                     
Sbjct: 687  QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT 746

Query: 742  -----CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
                 CRD++EC +G+ C  G C+N  GSFRCTC QGY  +     C D+DEC+   +C 
Sbjct: 747  PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 806

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQG 855
            +G C NT GSFQC C  GY  S    HCEDI+EC +  + C  GDCINT GSY C CP G
Sbjct: 807  HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG 866

Query: 856  HRL------------------------------------------VGGRKCQDIDECSQD 873
             +L                                            GR C+DIDEC  +
Sbjct: 867  FQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNN 926

Query: 874  PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG------------------CEEVE---- 911
             ++C  HG C N  GS+ C+C +GF   QD  G                  CE VE    
Sbjct: 927  -TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 985

Query: 912  ------------------------------QP-HHKKECYLNFDDTVFCDSVLATNVTQQ 940
                                          QP   KKECY N +D   CD+VLA NVT+Q
Sbjct: 986  CVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ 1045

Query: 941  ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DNNIVNYGIPAHRDIDECML 999
            ECCC+ GAGWGD+CEI+PCPV  +AEF  +CP GKG+     +    G   ++D DEC+L
Sbjct: 1046 ECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLL 1105

Query: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR 1059
            FG EICK G C+NT+PGYECYCKQG YYD   L+C D+DEC D S+C +G C NT G Y 
Sbjct: 1106 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1165

Query: 1060 CACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR 1119
            C CT P     ++++C+ P E +                                     
Sbjct: 1166 CFCTHPMVLDASEKRCIRPAESN------------------------------------- 1188

Query: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPP 1179
                     E     +D+CW    ++ +C+ PL G   T+ +CCC  G  WG QC  CP 
Sbjct: 1189 ------EQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL 1242

Query: 1180 RGA------------GSHCPTSQSESNSFW-----DTSPLLLGKPPRDEDSSEE-DSDEC 1221
            + +            G   P  +     F      +  P  +    R  +S EE  ++EC
Sbjct: 1243 KDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI--QDRFLNSFEELQAEEC 1300

Query: 1222 ----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTS 1277
                 C +GRCV    G  C+C  G+ LD ++  CVD++EC ELN R  LCK+ +C+NT 
Sbjct: 1301 GILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTD 1360

Query: 1278 GSFRCVCKAGFARSRPHGACVP 1299
            GS++C+C  G+  S     C P
Sbjct: 1361 GSYKCLCLPGYVPSDKPNYCTP 1382



 Score =  180 bits (457), Expect = 7e-45
 Identities = 152/575 (26%), Positives = 224/575 (38%), Gaps = 128/575 (22%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGIC 632
            + +EC  ++++C  G+C+     Y C C  G++    ++ C D+NECE    CGP +G C
Sbjct: 836  DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP-QGEC 893

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
            +NT GS++C C +G+   + A GR+C D++EC    +C   GFC N  G ++C CY G++
Sbjct: 894  LNTEGSFHCVCQQGFS--ISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 951

Query: 693  LKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYR-SQGGGACR------- 743
                    C D++EC   S  C +  CEN  GSF C+        S   G CR       
Sbjct: 952  APQDGQG-CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDL 1010

Query: 744  ---------DVNECA----EGSPCS-----------------PGW---CENLPGSF---- 766
                     +  EC     + S C                   GW   CE  P       
Sbjct: 1011 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTA 1070

Query: 767  ----RCTCAQGYAPAPD------GRSCLDVDECE--AGDVCDNGICSNTPGSFQCQCLSG 814
                 C   +G+ PA +      G +  D DEC     ++C NG C NT   ++C C  G
Sbjct: 1071 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1130

Query: 815  YHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-C-------QD 866
             +    +  C D+DEC  P++CI G C+NT GSY C C     L    K C       + 
Sbjct: 1131 TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQ 1190

Query: 867  IDECSQDPSLCLPHGACKNL--------QGSYV-CVCDEG--------FTPTQDQHGCEE 909
            I+E      LC  H + + +        Q +Y  C C  G          P +D     +
Sbjct: 1191 IEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1250

Query: 910  V--------EQPHHK------KECYLNFDDTVFCDSVLATNVT--QQECCCSLGAGWGDH 953
            +         QP+ +       E Y    D  F       +    Q E C  L       
Sbjct: 1251 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGR 1310

Query: 954  C----EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE--ICKE 1007
            C    E Y C  +             GY  D   +        D++EC    +   +CK 
Sbjct: 1311 CVRVQEGYTCDCFD------------GYHLDTAKMTCV-----DVNECDELNNRMSLCKN 1353

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
             KC+NT   Y+C C  G+        C  ++  L+
Sbjct: 1354 AKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALN 1388



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 80/295 (27%), Positives = 113/295 (38%), Gaps = 55/295 (18%)

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
            G C+NT   Y C+C +G   +       C D++EC  P  C DG  C+N  G Y C C  
Sbjct: 1114 GFCLNTRPGYECYCKQG--TYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYNCFCTH 1170

Query: 690  GYRLKAS-----RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRD 744
               L AS     RP   E  ++  +     D   E+    + C     G ++     C  
Sbjct: 1171 PMVLDASEKRCIRP--AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1228

Query: 745  VNECAEGSPC-------SPGWCE--NLPGSFR---------CTCAQGYAPAPDGRSCLD- 785
              E A G  C       S  + +  N+P + R            ++ Y P  D     D 
Sbjct: 1229 YGE-AWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1287

Query: 786  ---------VDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD----F 832
                      +EC   + C+NG C      + C C  GYHL   +  C D++ECD     
Sbjct: 1288 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1347

Query: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
             + C    CINT+GSY+CLC  G+              S  P+ C P     NL+
Sbjct: 1348 MSLCKNAKCINTDGSYKCLCLPGY------------VPSDKPNYCTPLNTALNLE 1390



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 15/47 (31%), Positives = 22/47 (46%)

Query: 572  VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            V E DE     ++C + +C+     Y C C PGY    +  YC  +N
Sbjct: 1338 VNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  789 bits (2037), Expect = 0.0
 Identities = 480/1323 (36%), Positives = 642/1323 (48%), Gaps = 216/1323 (16%)

Query: 60   ERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMN 119
            ++ K+VF P ICK+TC +G C +SC++G   TL  + GH  D    SGFR+  C +PC+N
Sbjct: 349  KKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK--SGFRIYFCQIPCLN 406

Query: 120  GGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSV 179
            GG+C  R++C CP + TG+FC +P                              P+ D  
Sbjct: 407  GGRCIGRDECWCPANSTGKFCHLP-----------------------------IPQPD-- 435

Query: 180  ASKHAIYAVQVIADPPGPGEGP------PAQHAAFLVPLGPGQISAEVQAPPPVVNVRVH 233
                         +PPG G  P      P + + F +PL     S      P +V V +H
Sbjct: 436  ------------REPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVN----PSLVKVHIH 479

Query: 234  HPPEASVQVHRIES----------SNAESAAPSQHLLPHP---------------KPSHP 268
            HPPEASVQ+H++             N+    P   L   P               +P  P
Sbjct: 480  HPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRP 539

Query: 269  RPP-TQKP---LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY 324
             PP   +P   LGRC+ +T+  Q C +NPL  LT QEDCCGS+G  WG + C  CP    
Sbjct: 540  LPPAAPRPRGLLGRCYLNTVNGQ-C-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPA 597

Query: 325  TGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            + V + G +      +CPQGYKRLN THCQDINEC   G+C+  +C+N  GSY C C PG
Sbjct: 598  SPVIENGQL------ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG 651

Query: 385  HSLGPSRTQCIADKPEE--KSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQ 441
              L PSR++C++DK     + LC+R + P   C  PL  R+T+Q+CCCS VGKAWG+ C+
Sbjct: 652  LMLDPSRSRCVSDKAISMLQGLCYRSLGP-GTCTLPLAQRITKQICCCSRVGKAWGSECE 710

Query: 442  RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAP 501
            +CP  GT AF+EICPAG GY   +S   L+++   +  L       P  +Q   S    P
Sbjct: 711  KCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEEL-----ARPPREQGQRSSGALP 765

Query: 502  PPEDTEEERGVT---TDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDL 558
             P + +  R VT    ++    ++   Q+    T+    P     +  +PP         
Sbjct: 766  GPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPM-------- 817

Query: 559  PPSRSAVEIAPTQVTET------------DECRLN-QNICGHGECVPGPPDYSCHCNPGY 605
             P +   EI   QVT +            D C     N+CG G CV  P  Y C C+PGY
Sbjct: 818  -PEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGY 876

Query: 606  RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
            + HP   YC D NEC  +PC  G+G C+N  GSY+C C  GY L      + C D+NEC 
Sbjct: 877  QLHPSQAYCTDDNECLRDPC-KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE 935

Query: 666  KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSF 725
            +P +C  GG C N  G Y C C  GY +   R   C+DI+ECR P +CPDG+C N PGS+
Sbjct: 936  QPGVC-SGGQCTNTEGSYHCECDQGYIM--VRKGHCQDINECRHPGTCPDGRCVNSPGSY 992

Query: 726  KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
             C+AC+ GYR Q  G+C DVNEC     C+ G C NL GSFRC+C QGY    D + C D
Sbjct: 993  TCLACEEGYRGQ-SGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD 1051

Query: 786  VDECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
            VDEC +   C  G+C NT GSF C  C +GY ++ D + CED+DEC FP  C  G C NT
Sbjct: 1052 VDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNT 1111

Query: 845  NGSYRCL-CPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF---- 898
             GS+ C  C  G+R    G  C+D+DEC    S CL  G CKN  GSY C+C +GF    
Sbjct: 1112 AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLAN 1170

Query: 899  -TPTQDQHGCEEVEQPHHKKECYLNFDDTVFC-------DSVLATNVTQQECCCSLGAGW 950
             T  +D + C   E      EC LN   + FC        +   T+    + C +     
Sbjct: 1171 GTVCEDVNECMGEEHCAPHGEC-LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCV 1229

Query: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKC 1010
            G HC      V +   F+ LC  G   + ++           DIDEC  +G  +C   KC
Sbjct: 1230 GGHC------VNTEGSFNCLCETGFQPSPESG-------ECVDIDECEDYGDPVCGTWKC 1276

Query: 1011 VNTQPGYECY--CKQGFYYDGNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAE 1067
             N+   Y C   C+ GF+   N  +C+D+DEC +++ C  +G C+NT G +RC C    E
Sbjct: 1277 ENSPGSYRCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335

Query: 1068 YSPAQRQCLSPEEMDVDECQ-DPAACRPGRCVNLPGSYRC--------------ECRPPW 1112
             SP+   C     +DV+EC+   A C    C N+ GS+ C               CRP  
Sbjct: 1336 ISPSGWDC-----VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390

Query: 1113 VPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGA 1172
              G S  +   P      AP R D C+S +     C+  L G   T  +CCC QG  WG 
Sbjct: 1391 AGGQSMSEA--PTGDHAPAPTRMD-CYSGQKGHAPCSSVL-GRNTTQAECCCTQGASWGD 1446

Query: 1173 QCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD-----EDSSEEDSDEC------ 1221
             C  CP             +S  F +  P   G  P +       +   D+DEC      
Sbjct: 1447 ACDLCP-----------SEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPG 1495

Query: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
             C +GRC+    G VC C  GF  DAS  +C D DEC++     L C++  CVNT GSF 
Sbjct: 1496 LCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQD-----LACENGECVNTEGSFH 1550

Query: 1282 CVC 1284
            C C
Sbjct: 1551 CFC 1553



 Score =  419 bits (1076), Expect = e-116
 Identities = 238/677 (35%), Positives = 324/677 (47%), Gaps = 125/677 (18%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC L   +C HG+C      + C C  GY      + C DV+EC +    P  G+C+
Sbjct: 1010 DVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP-TGLCL 1067

Query: 634  NTGGSYNCH-CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKC-NCYPGY 691
            NT GS+ C  C  GY   V   G +C DL+ECA P +C   G C N  G + C +C  GY
Sbjct: 1068 NTEGSFACSACENGY--WVNEDGTACEDLDECAFPGVC-PSGVCTNTAGSFSCKDCDGGY 1124

Query: 692  RLKASRPPVCEDIDECRDP-SSCPDGKCENKPGSFKCIA--------------------- 729
            R  +     CED+DEC DP SSC  G+C+N  GS++C+                      
Sbjct: 1125 R-PSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGE 1183

Query: 730  -------------------CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCT 769
                               C PG+ S +GG +C+DV+ECA   PC  G C N  GSF C 
Sbjct: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCL 1243

Query: 770  CAQGYAPAPDGRSCLDVDECEA-GD-VCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCE 825
            C  G+ P+P+   C+D+DECE  GD VC    C N+PGS++C   C  G+H++ +   C 
Sbjct: 1244 CETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN-GDCI 1302

Query: 826  DIDECDFPAACIG-GDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA- 882
            DIDEC     C   G C NT+GS+RCLC QG  +   G  C D++EC    ++C   GA 
Sbjct: 1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVC---GAA 1359

Query: 883  -CKNLQGSYVCVCDEGFTPTQDQHG-----------CEEVEQPHH-----KKECYLNFDD 925
             C+N++GS++C+C         Q G             E     H     + +CY     
Sbjct: 1360 LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG 1419

Query: 926  TVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVN 985
               C SVL  N TQ ECCC+ GA WGD C++  CP   SAEF  +CP GKGY        
Sbjct: 1420 HAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSEDSAEFSEICPSGKGYIPVEGAWT 1477

Query: 986  YGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN 1045
            +G   + D DEC++FG  +C  G+C+NT PGY C C  GF+YD +  +C D DEC D + 
Sbjct: 1478 FGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA- 1536

Query: 1046 CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYR 1105
            C NG C NT G + C C+PP     +Q++C++      D                     
Sbjct: 1537 CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTED--------------------- 1575

Query: 1106 CECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCR 1165
                             LP+          D+CW +   D +C+ PL G   T+ +CCC+
Sbjct: 1576 -----------------LPDHDI-----HMDICWKKVTND-VCSEPLRGHRTTYTECCCQ 1612

Query: 1166 QGRGWGAQCRPCPPRGA 1182
             G  W  QC  CPPR +
Sbjct: 1613 DGEAWSQQCALCPPRSS 1629



 Score =  279 bits (714), Expect = 1e-74
 Identities = 201/613 (32%), Positives = 260/613 (42%), Gaps = 131/613 (21%)

Query: 704  IDECRDPSS--CPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCE 760
            ID C   ++  C  G C N P  ++C+ C PGY+     A C D NEC        G C 
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCV-CSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903

Query: 761  NLPGSFRCTCAQGYAPAPDG--RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLS 818
            N  GS+ C C  GY  A  G  + C D++ECE   VC  G C+NT GS+ C+C  GY + 
Sbjct: 904  NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963

Query: 819  RDRSHCEDIDECDFPAACIGGDCINTNGSYRCL-CPQGHRLVGGRKCQDIDECSQDPSLC 877
            R + HC+DI+EC  P  C  G C+N+ GSY CL C +G+R   G  C D++EC   P +C
Sbjct: 964  R-KGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSG-SCVDVNECLT-PGVC 1020

Query: 878  LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
              HG C NL+GS+ C C++G+  T D+ GC++V+      EC         C + L  N 
Sbjct: 1021 A-HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD------ECA----SRASCPTGLCLNT 1069

Query: 938  TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
                 C                         S C +G    +D         A  D+DEC
Sbjct: 1070 EGSFAC-------------------------SACENGYWVNEDGT-------ACEDLDEC 1097

Query: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLE-CVDVDECLD-ESNCRNGVCENTR 1055
               G  +C  G C NT   + C    G Y    L + C DVDEC D +S+C  G C+NT 
Sbjct: 1098 AFPG--VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155

Query: 1056 GGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRP-GRCVNLPGSYRCECRPPWVP 1114
            G Y+C C  P  +  A          DV+EC     C P G C+N  GS+ C C P +V 
Sbjct: 1156 GSYQCLC--PQGFQLANGTVCE----DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVS 1209

Query: 1115 GPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1174
               G  CQ             DV                      D+C         A  
Sbjct: 1210 AEGGTSCQ-------------DV----------------------DEC---------ATT 1225

Query: 1175 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRC 1228
             PC     G HC  ++   N   +T     G  P  E     D DEC       C + +C
Sbjct: 1226 DPC----VGGHCVNTEGSFNCLCET-----GFQPSPESGECVDIDECEDYGDPVCGTWKC 1276

Query: 1229 VPRPGGAVCE--CPGGFQLDASRARCVDIDECRELNQRGLLCKSER-CVNTSGSFRCVCK 1285
               PG   C   C  GF + A    C+DIDEC        +C S   C NT GSFRC+C 
Sbjct: 1277 ENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN----DTMCGSHGFCDNTDGSFRCLCD 1331

Query: 1286 AGFARSRPHGACV 1298
             GF  S     CV
Sbjct: 1332 QGFEISPSGWDCV 1344



 Score =  235 bits (599), Expect = 2e-61
 Identities = 238/936 (25%), Positives = 347/936 (37%), Gaps = 194/936 (20%)

Query: 306  SIGTAWGQSKCHKCPQLQYTGVQKPGP---VRGEVGADCPQGYKRLNSTHCQDINECAMP 362
            ++ T+    +C    + +  GV   G      G    +C QGY  +   HCQDINEC  P
Sbjct: 918  TLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHP 977

Query: 363  GVCRHGDCLNNPGSYRCV-CPPGHSLGPSRT-----QCIADKPEEKSLC----------- 405
            G C  G C+N+PGSY C+ C  G+  G S +     +C+         C           
Sbjct: 978  GTCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSC 1036

Query: 406  ---FRLVSPEHQCQH----PLTTRLTRQLCCCSVGKAWGARCQR---CPTDGTA------ 449
               + + S E  CQ              LC  + G    + C+       DGTA      
Sbjct: 1037 EQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096

Query: 450  -AFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEE 508
             AF  +CP+G   +   S                  DG  +P  L +S       ED + 
Sbjct: 1097 CAFPGVCPSGVCTNTAGSFSCKDC------------DGGYRPSPLGDSCEDVDECEDPQS 1144

Query: 509  E--RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISR----PSPPTMR----WFLPDL 558
                G   ++  S +    Q    A  T      E +      P    +     +F    
Sbjct: 1145 SCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204

Query: 559  PPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            P   SA     T   + DEC       G G CV     ++C C  G++  P+   CVD++
Sbjct: 1205 PGFVSAE--GGTSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPESGECVDID 1261

Query: 619  ECE--AEP-CGPGRGICMNTGGSYNC--HCNRGYRLHVGAGGRSCVDLNECAKPHLCGDG 673
            ECE   +P CG  +  C N+ GSY C   C  G+  H+   G  C+D++ECA   +CG  
Sbjct: 1262 ECEDYGDPVCGTWK--CENSPGSYRCVLGCQPGF--HMAPNG-DCIDIDECANDTMCGSH 1316

Query: 674  GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIAC-- 730
            GFC N  G ++C C  G+ +  S    C D++EC    + C    CEN  GSF C+    
Sbjct: 1317 GFCDNTDGSFRCLCDQGFEISPSGWD-CVDVNECELMLAVCGAALCENVEGSFLCLCASD 1375

Query: 731  ------QPGYRSQGGGACRDVNECAEG------------------SPCSPGWCENLPGSF 766
                  Q G+    G   + ++E   G                  +PCS     N   + 
Sbjct: 1376 LEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA- 1434

Query: 767  RCTCAQGYA------------------PAPDGRSCL--------------DVDECE--AG 792
             C C QG +                    P G+  +              D DEC     
Sbjct: 1435 ECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGP 1494

Query: 793  DVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLC 852
             +C NG C NT   + C C  G+H       CED DEC    AC  G+C+NT GS+ C C
Sbjct: 1495 GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ-DLACENGECVNTEGSFHCFC 1553

Query: 853  PQGHRL-VGGRKCQDIDECSQD-------PSLC---LPHGACKN-LQGSYV----CVCDE 896
                 L +  ++C +    ++D         +C   + +  C   L+G       C C +
Sbjct: 1554 SPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQD 1613

Query: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD-HCE 955
            G   +Q    C     P    E Y    +    ++     V  +      G G  D H  
Sbjct: 1614 GEAWSQQCALC-----PPRSSEVYAQLCNVARIEAEREAGVHFRPGY-EYGPGPDDLHYS 1667

Query: 956  IY-----------------PCPVYSSAEFHSL--CPDGKGYTQDNNIVNYGIPAHRD--- 993
            IY                 P P + +   HS    P  +   Q + +  + + +H +   
Sbjct: 1668 IYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPA 1727

Query: 994  ------IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-- 1045
                   +EC +     C+ G+CV  + GY C C +GF  D   + CVDV+EC D +   
Sbjct: 1728 GFEGLQAEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPA 1785

Query: 1046 --CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
              C +G CENT G YRC C+P          C + E
Sbjct: 1786 VLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821



 Score =  134 bits (337), Expect = 6e-31
 Identities = 124/463 (26%), Positives = 183/463 (39%), Gaps = 104/463 (22%)

Query: 254  APSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQ 313
            A  Q +   P   H   PT+     C+       PC S+ L   T Q +CC + G +WG 
Sbjct: 1391 AGGQSMSEAPTGDHAPAPTRMD---CYSGQKGHAPC-SSVLGRNTTQAECCCTQGASWGD 1446

Query: 314  SKCHKCPQ---LQYTGVQKPG----PVRGE--------VGAD---------CPQGYKRLN 349
            + C  CP     +++ +   G    PV G           AD         CP G + LN
Sbjct: 1447 A-CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLN 1504

Query: 350  ST------------------HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            +                    C+D +EC     C +G+C+N  GS+ C C P  +L  S+
Sbjct: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDEC-QDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563

Query: 392  TQCI------ADKPEEK---SLCFRLVSPEHQCQHPLTT-RLTRQLCCCSVGKAWGARCQ 441
             +C+       D P+      +C++ V+ +  C  PL   R T   CCC  G+AW  +C 
Sbjct: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCA 1622

Query: 442  RCPTDGTAAFKEICPAGK-------GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLP 494
             CP   +  + ++C   +       G H    ++      +  +S++  PDG P    L 
Sbjct: 1623 LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIY-GPDGAPFYNYL- 1680

Query: 495  ESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELI-SRPSPPTMRW 553
                    PEDT  E      +  S +R+     P     P+   P  + S P PP    
Sbjct: 1681 -------GPEDTVPEPAFPNTAGHSADRTPILESP---LQPSELQPHYVASHPEPP---- 1726

Query: 554  FLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRY 613
                          A  +  + +EC +  N C +G CV     Y+C C  G++    H  
Sbjct: 1727 --------------AGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771

Query: 614  CVDVNECEAEPCGPG----RGICMNTGGSYNCHCNRGYRLHVG 652
            CVDVNEC+ +  GP      G C NT GSY CHC+ GY    G
Sbjct: 1772 CVDVNECD-DLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAG 1813



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 54/207 (26%), Positives = 68/207 (32%), Gaps = 68/207 (32%)

Query: 1110 PPWVPGPSG-----------RDCQLPESPAERAPERRDV---CWSQRGEDGMCAGPLAGP 1155
            PPW+P   G           R  + P      AP  R +   C+     +G CA PL   
Sbjct: 512  PPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNT-VNGQCANPLL-E 569

Query: 1156 ALTFDDCCCRQGRGWGAQ-CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1214
              T +DCC   G  WG   C PC                             PPR     
Sbjct: 570  LTTQEDCCGSVGAFWGVTLCAPC-----------------------------PPRPASPV 600

Query: 1215 EEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCV 1274
             E+                    ECP G++   +   C DI+EC  L     LCK   CV
Sbjct: 601  IENGQ-----------------LECPQGYKR-LNLTHCQDINECLTLG----LCKDAECV 638

Query: 1275 NTSGSFRCVCKAGFARSRPHGACVPQR 1301
            NT GS+ C C+ G         CV  +
Sbjct: 639  NTRGSYLCTCRPGLMLDPSRSRCVSDK 665



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 53/199 (26%), Positives = 67/199 (33%), Gaps = 45/199 (22%)

Query: 112 VCPLPCMNGGQCSSRNQCLCPPDFTGRFCQ--VP--------AGGAGGGTGGSGPGLSRT 161
           VC  PC N G CS    C+C   F G  C+  +P        +  A        P L R+
Sbjct: 190 VCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRS 249

Query: 162 GALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV 221
            A   G L    P                   PP P + PPA   + L    P Q    +
Sbjct: 250 SAAGEGTLARAQPPAPQ--------------SPPAP-QSPPAGTLSGLSQTHPSQQHVGL 294

Query: 222 QAPPPVVNVRVHHPPEASVQVHRIESSNAESAAP-------SQHLLPHPKPSHP----RP 270
                   VR+H    AS Q+    SSNA    P       +Q  +P   PS P      
Sbjct: 295 SR-----TVRLHPTATASSQL----SSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLT 345

Query: 271 PTQKPLGRCFQDTLPKQPC 289
              K +   F  T+ KQ C
Sbjct: 346 EKIKKIKIVFTPTICKQTC 364


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  637 bits (1642), Expect = 0.0
 Identities = 457/1413 (32%), Positives = 597/1413 (42%), Gaps = 278/1413 (19%)

Query: 20   AAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKG- 78
            A G+  L + LL+LL  LG +   G  GER             +V F PV+C   C+ G 
Sbjct: 2    AGGVRLLWVSLLVLLAQLGPQPGLGRLGER------------LRVRFTPVVCGLRCVHGP 49

Query: 79   ---QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDF 135
               +C  +C    N T +           G GFR  +CPL C NGG C   ++CLCPPDF
Sbjct: 50   TGSRCTPTCAP-RNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDF 108

Query: 136  TGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPP 195
             G+FCQ+ + GA                                              PP
Sbjct: 109  AGKFCQLHSSGAR---------------------------------------------PP 123

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIES-------- 247
             P   P    + + +PL   +      A   +V+V V HP EASV VH++E         
Sbjct: 124  APAV-PGLTRSVYTMPLANHRDDEHGVAS--MVSVHVEHPQEASVVVHQVERVSGPWEEA 180

Query: 248  -----SNAESAAPSQHLLPHPKPSHPRPPTQ-----KPLGRCFQDTLPKQPCGSNPLPGL 297
                 + AE+AA ++   P+   +   P           G CF++ L    C S PLPGL
Sbjct: 181  DAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRE-LRGGECAS-PLPGL 238

Query: 298  TKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDIN 357
              QE CC   G AWG   C  C +      +   P        CP G++R+N + C+D++
Sbjct: 239  RTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP-----DGPCPTGFERVNGS-CEDVD 292

Query: 358  ECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK--PEEKSLCFRLVSPEHQC 415
            ECA  G C+HG+C N  G Y CVCP G  L  SR+ CI+     E K  CFR++  +  C
Sbjct: 293  ECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR-DGGC 351

Query: 416  QHPLTTRLTRQLCCCS-VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474
              P+   +T+Q+CCCS VGKAWG  CQ CP  G+  F+EICPAG GYH            
Sbjct: 352  SLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHY----------S 401

Query: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534
             SD      P G   P+     P   P            T  P +      +  P     
Sbjct: 402  ASDLRYNTRPLGQEPPRVSLSQPRTLP-----------ATSRPSAGFLPTHRLEPRPEPR 450

Query: 535  P-ARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPG 593
            P  RP PEL   P P    W  P++P S  +          +  C+ N  +CG G C+  
Sbjct: 451  PDPRPGPEL---PLPSIPAWTGPEIPESGPS----------SGMCQRNPQVCGPGRCISR 497

Query: 594  PPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGR---------------------- 629
            P  Y+C C+ G+R  PQ   C+DV+EC     PC PGR                      
Sbjct: 498  PSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRA 557

Query: 630  ------------------GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLC 670
                              G C NT GS+ C C  GY+      G SC D++EC + P LC
Sbjct: 558  AECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ--AAPHGASCQDVDECTQSPGLC 615

Query: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIA 729
            G G  C N PG ++C C  G+R  A      ED+DEC ++P  C  G+C+N  GSF C A
Sbjct: 616  GRGA-CKNLPGSFRCVCPAGFRGSACE----EDVDECAQEPPPCGPGRCDNTAGSFHC-A 669

Query: 730  CQPGYRSQGGGA-CRDVNECAEGSP-CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVD 787
            C  G+RS+G GA C+DV+ECA   P C+ G CEN  GSF+C C  G+ P   G  C DVD
Sbjct: 670  CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVD 729

Query: 788  ECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIG--GDCINT 844
            ECE    C    C N+PGSFQC+ C SG+HL R R  C D+DEC   A   G  G C NT
Sbjct: 730  ECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNT 787

Query: 845  NGSYRCLCPQGHRLVGGRK--CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ 902
             GS+RC C  G+R   GR   C D++EC +    C PHG C N  GS+ C C  G+ P  
Sbjct: 788  EGSFRCSCAPGYRAPSGRPGPCADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGP 846

Query: 903  DQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQ-ECCCSLGAGWGDHC----EIY 957
                C +V+      EC     +   C S + TN     EC C  G   G       ++ 
Sbjct: 847  RGASCLDVD------EC----SEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVD 896

Query: 958  PC----PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--DIDECMLFGSEICKEGKCV 1011
             C    P    ++     P      +D +   +  P     D+DEC  +G EIC   +C 
Sbjct: 897  ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCE 956

Query: 1012 NTQPGYECY--CKQGFYYDGNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAEY 1068
            NT   Y C   C  G Y       C DVDEC + S C  + VC+N  G ++C C    E 
Sbjct: 957  NTPGSYRCTPACDPG-YQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1015

Query: 1069 SPAQRQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRCEC------------------- 1108
            +   R C+     DV+EC+     C    C N+ GS+ C C                   
Sbjct: 1016 ARDGRHCV-----DVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1070

Query: 1109 -------RPPWVPGPSGRDCQLPESPAERAPER---------RDVCWSQRGEDGMCAGPL 1152
                     P  P       + P  P  R P           R  C+        C   L
Sbjct: 1071 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNIL 1130

Query: 1153 AGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP-TSQSESNSFWDTSPLLLGKPPRDE 1211
            A   +T+ +CCC  G GWG+ CR          CP T  +E  S        L   P  +
Sbjct: 1131 ARN-VTWQECCCTVGEGWGSGCRI-------QQCPGTETAEYQSLCPHGRGYLA--PSGD 1180

Query: 1212 DSSEEDSDECR------CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRG 1265
             S   D DEC+      C SG CV    G  C C  G+     R  C+D DEC +     
Sbjct: 1181 LSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEP-- 1238

Query: 1266 LLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
              C+  RCVNT GS+ C C+           CV
Sbjct: 1239 -ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1270



 Score =  508 bits (1307), Expect = e-143
 Identities = 393/1255 (31%), Positives = 515/1255 (41%), Gaps = 231/1255 (18%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 381  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 437

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 438  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 489

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 490  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 535

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 536  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 586

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 587  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 636

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 637  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 695

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 696  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 754

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 755  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 810

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 811  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 869

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 870  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 928

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 929  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 986

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 987  RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1043

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1044 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1103

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1104 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1163

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1164 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1219

Query: 1027 YDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVD- 1084
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S E   +D 
Sbjct: 1220 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD 1279

Query: 1085 ---------------------------EC---------QDPAAC---------------- 1092
                                       EC          D A C                
Sbjct: 1280 NLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLR 1339

Query: 1093 -------RPGRCVNLPGSYRCECRPPWVPGPSGRDCQ----LPESPAERAPERRDVCWSQ 1141
                   RPG    LP  Y  +  PP+   P G +      LP  P    P         
Sbjct: 1340 PPAYSPPRPGG-FGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPP--------- 1389

Query: 1142 RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP-TSQSESNSFWDTS 1200
             G       P   P     D     G  +G    P PP G G+  P  S+    SF +  
Sbjct: 1390 -GPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-GPGTRWPYRSRDTRRSFPEPE 1446

Query: 1201 PLLLGKPPRD--------EDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDAS 1248
                 +PP          E   E +++EC     C +GRCV  P G  C C  G++LD +
Sbjct: 1447 -----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMT 1501

Query: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
            R  CVDI+EC E      LC + RC+NT GSFRC+C+ GFA +     C P R R
Sbjct: 1502 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPR 1556



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1146 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1195
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 229  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 286

Query: 1196 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1251
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 287  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 328

Query: 1252 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 329  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 382



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1358 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1407

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1408 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1459

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1460 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1516

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1517 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1555


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  612 bits (1577), Expect = e-175
 Identities = 431/1323 (32%), Positives = 562/1323 (42%), Gaps = 261/1323 (19%)

Query: 106  SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALS 165
            +G   V+CPL C NGG C   ++CLCPPDF G+FCQ+ + GA                  
Sbjct: 109  AGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGAR----------------- 151

Query: 166  TGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPP 225
                                        PP P   P    + + +PL   +      A  
Sbjct: 152  ----------------------------PPAPAV-PGLTRSVYTMPLANHRDDEHGVAS- 181

Query: 226  PVVNVRVHHPPEASVQVHRIES-------------SNAESAAPSQHLLPHPKPSHPRPPT 272
             +V+V V HP EASV VH++E              + AE+AA ++   P+   +   P  
Sbjct: 182  -MVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPRE 240

Query: 273  Q-----KPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV 327
                     G CF++ L    C S PLPGL  QE CC   G AWG   C  C +      
Sbjct: 241  DGYSDASGFGYCFRE-LRGGECAS-PLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSE 298

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            +   P        CP G++R+N + C+D++ECA  G C+HG+C N  G Y CVCP G  L
Sbjct: 299  RVSAP-----DGPCPTGFERVNGS-CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 352

Query: 388  GPSRTQCIADK--PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQRCP 444
              SR+ CI+     E K  CFR++  +  C  P+   +T+Q+CCCS VGKAWG  CQ CP
Sbjct: 353  DSSRSSCISQHVISEAKGPCFRVLR-DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 411

Query: 445  TDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPE 504
              G+  F+EICPAG GYH             SD      P G   P+     P   P   
Sbjct: 412  PFGSEGFREICPAGPGYHY----------SASDLRYNTRPLGQEPPRVSLSQPRTLP--- 458

Query: 505  DTEEERGVTTDSPVSEERSVQQSHPTATTTP-ARPYPELISRPSPPTMRWFLPDLPPSRS 563
                     T  P +      +  P     P  RP PEL   P P    W  P++P S  
Sbjct: 459  --------ATSRPSAGFLPTHRLEPRPEPRPDPRPGPEL---PLPSIPAWTGPEIPESGP 507

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA- 622
            +          +  C+ N  +CG G C+  P  Y+C C+ G+R  PQ   C+DV+EC   
Sbjct: 508  S----------SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 557

Query: 623  -EPCGPGR----------------------------------------GICMNTGGSYNC 641
              PC PGR                                        G C NT GS+ C
Sbjct: 558  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLC 617

Query: 642  HCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
             C  GY+      G SC D++EC + P LCG G  C N PG ++C C  G+R  A     
Sbjct: 618  VCPAGYQ--AAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE--- 671

Query: 701  CEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP-CSPG 757
             ED+DEC ++P  C  G+C+N  GSF C AC  G+RS+G GA C+DV+ECA   P C+ G
Sbjct: 672  -EDVDECAQEPPPCGPGRCDNTAGSFHC-ACPAGFRSRGPGAPCQDVDECARSPPPCTYG 729

Query: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQ-CLSGYH 816
             CEN  GSF+C C  G+ P   G  C DVDECE    C    C N+PGSFQC+ C SG+H
Sbjct: 730  RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 789

Query: 817  LSRDRSHCEDIDECDFPAACIG--GDCINTNGSYRCLCPQGHRLVGGRK--CQDIDECSQ 872
            L R R  C D+DEC   A   G  G C NT GS+RC C  G+R   GR   C D++EC +
Sbjct: 790  LHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE 847

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
                C PHG C N  GS+ C C  G+ P      C +V+      EC     +   C S 
Sbjct: 848  G-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD------EC----SEEDLCQSG 896

Query: 933  LATNVTQQ-ECCCSLGAGWGDHC----EIYPC----PVYSSAEFHSLCPDGKGYTQDNNI 983
            + TN     EC C  G   G       ++  C    P    ++     P      +D + 
Sbjct: 897  ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 956

Query: 984  VNYGIPAHR--DIDECMLFGSEICKEGKCVNTQPGYECY--CKQGFYYDGNLLECVDVDE 1039
              +  P     D+DEC  +G EIC   +C NT   Y C   C  G Y       C DVDE
Sbjct: 957  GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPG-YQPTPGGGCQDVDE 1015

Query: 1040 CLDESNC-RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRC 1097
            C + S C  + VC+N  G ++C C    E +   R C+     DV+EC+     C    C
Sbjct: 1016 CRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCV-----DVNECETLQGVCGAALC 1070

Query: 1098 VNLPGSYRCEC--------------------------RPPWVPGPSGRDCQLPESPAERA 1131
             N+ GS+ C C                            P  P       + P  P  R 
Sbjct: 1071 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1130

Query: 1132 PER---------RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA 1182
            P           R  C+        C   LA   +T+ +CCC  G GWG+ CR       
Sbjct: 1131 PSTPRQGPVGSGRRECYFDTAAPDACDNILARN-VTWQECCCTVGEGWGSGCRI------ 1183

Query: 1183 GSHCP-TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRCVPRPGGA 1235
               CP T  +E  S        L   P  + S   D DEC+      C SG CV    G 
Sbjct: 1184 -QQCPGTETAEYQSLCPHGRGYLA--PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1240

Query: 1236 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1295
             C C  G+     R  C+D DEC +       C+  RCVNT GS+ C C+          
Sbjct: 1241 SCYCSNGYYYHTQRLECIDNDECADEEP---ACEGGRCVNTVGSYHCTCEPPLVLDGSQR 1297

Query: 1296 ACV 1298
             CV
Sbjct: 1298 RCV 1300



 Score =  508 bits (1307), Expect = e-143
 Identities = 393/1255 (31%), Positives = 515/1255 (41%), Gaps = 231/1255 (18%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 411  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 467

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 468  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 519

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 520  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 565

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 566  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 616

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 617  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 666

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 667  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 725

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 726  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 784

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 785  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 840

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 841  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 899

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 900  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 958

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 959  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 1016

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 1017 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1073

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1074 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1133

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1134 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1193

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1194 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1249

Query: 1027 YDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVD- 1084
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S E   +D 
Sbjct: 1250 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD 1309

Query: 1085 ---------------------------EC---------QDPAAC---------------- 1092
                                       EC          D A C                
Sbjct: 1310 NLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLR 1369

Query: 1093 -------RPGRCVNLPGSYRCECRPPWVPGPSGRDCQ----LPESPAERAPERRDVCWSQ 1141
                   RPG    LP  Y  +  PP+   P G +      LP  P    P         
Sbjct: 1370 PPAYSPPRPGG-FGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPP--------- 1419

Query: 1142 RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP-TSQSESNSFWDTS 1200
             G       P   P     D     G  +G    P PP G G+  P  S+    SF +  
Sbjct: 1420 -GPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-GPGTRWPYRSRDTRRSFPEPE 1476

Query: 1201 PLLLGKPPRD--------EDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDAS 1248
                 +PP          E   E +++EC     C +GRCV  P G  C C  G++LD +
Sbjct: 1477 -----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMT 1531

Query: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
            R  CVDI+EC E      LC + RC+NT GSFRC+C+ GFA +     C P R R
Sbjct: 1532 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPR 1586



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1146 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1195
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 259  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 316

Query: 1196 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1251
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 317  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 358

Query: 1252 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 359  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 412



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1388 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1437

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1438 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1489

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1490 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1546

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1547 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1585


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  612 bits (1577), Expect = e-175
 Identities = 431/1323 (32%), Positives = 562/1323 (42%), Gaps = 261/1323 (19%)

Query: 106  SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALS 165
            +G   V+CPL C NGG C   ++CLCPPDF G+FCQ+ + GA                  
Sbjct: 146  AGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGAR----------------- 188

Query: 166  TGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPP 225
                                        PP P   P    + + +PL   +      A  
Sbjct: 189  ----------------------------PPAPAV-PGLTRSVYTMPLANHRDDEHGVAS- 218

Query: 226  PVVNVRVHHPPEASVQVHRIES-------------SNAESAAPSQHLLPHPKPSHPRPPT 272
             +V+V V HP EASV VH++E              + AE+AA ++   P+   +   P  
Sbjct: 219  -MVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPRE 277

Query: 273  Q-----KPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV 327
                     G CF++ L    C S PLPGL  QE CC   G AWG   C  C +      
Sbjct: 278  DGYSDASGFGYCFRE-LRGGECAS-PLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSE 335

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            +   P        CP G++R+N + C+D++ECA  G C+HG+C N  G Y CVCP G  L
Sbjct: 336  RVSAP-----DGPCPTGFERVNGS-CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 389

Query: 388  GPSRTQCIADK--PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQRCP 444
              SR+ CI+     E K  CFR++  +  C  P+   +T+Q+CCCS VGKAWG  CQ CP
Sbjct: 390  DSSRSSCISQHVISEAKGPCFRVLR-DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 448

Query: 445  TDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPE 504
              G+  F+EICPAG GYH             SD      P G   P+     P   P   
Sbjct: 449  PFGSEGFREICPAGPGYHY----------SASDLRYNTRPLGQEPPRVSLSQPRTLP--- 495

Query: 505  DTEEERGVTTDSPVSEERSVQQSHPTATTTP-ARPYPELISRPSPPTMRWFLPDLPPSRS 563
                     T  P +      +  P     P  RP PEL   P P    W  P++P S  
Sbjct: 496  --------ATSRPSAGFLPTHRLEPRPEPRPDPRPGPEL---PLPSIPAWTGPEIPESGP 544

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA- 622
            +          +  C+ N  +CG G C+  P  Y+C C+ G+R  PQ   C+DV+EC   
Sbjct: 545  S----------SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 594

Query: 623  -EPCGPGR----------------------------------------GICMNTGGSYNC 641
              PC PGR                                        G C NT GS+ C
Sbjct: 595  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLC 654

Query: 642  HCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
             C  GY+      G SC D++EC + P LCG G  C N PG ++C C  G+R  A     
Sbjct: 655  VCPAGYQ--AAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE--- 708

Query: 701  CEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP-CSPG 757
             ED+DEC ++P  C  G+C+N  GSF C AC  G+RS+G GA C+DV+ECA   P C+ G
Sbjct: 709  -EDVDECAQEPPPCGPGRCDNTAGSFHC-ACPAGFRSRGPGAPCQDVDECARSPPPCTYG 766

Query: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQ-CLSGYH 816
             CEN  GSF+C C  G+ P   G  C DVDECE    C    C N+PGSFQC+ C SG+H
Sbjct: 767  RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 826

Query: 817  LSRDRSHCEDIDECDFPAACIG--GDCINTNGSYRCLCPQGHRLVGGRK--CQDIDECSQ 872
            L R R  C D+DEC   A   G  G C NT GS+RC C  G+R   GR   C D++EC +
Sbjct: 827  LHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE 884

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
                C PHG C N  GS+ C C  G+ P      C +V+      EC     +   C S 
Sbjct: 885  G-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD------EC----SEEDLCQSG 933

Query: 933  LATNVTQQ-ECCCSLGAGWGDHC----EIYPC----PVYSSAEFHSLCPDGKGYTQDNNI 983
            + TN     EC C  G   G       ++  C    P    ++     P      +D + 
Sbjct: 934  ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 993

Query: 984  VNYGIPAHR--DIDECMLFGSEICKEGKCVNTQPGYECY--CKQGFYYDGNLLECVDVDE 1039
              +  P     D+DEC  +G EIC   +C NT   Y C   C  G Y       C DVDE
Sbjct: 994  GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPG-YQPTPGGGCQDVDE 1052

Query: 1040 CLDESNC-RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRC 1097
            C + S C  + VC+N  G ++C C    E +   R C+     DV+EC+     C    C
Sbjct: 1053 CRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCV-----DVNECETLQGVCGAALC 1107

Query: 1098 VNLPGSYRCEC--------------------------RPPWVPGPSGRDCQLPESPAERA 1131
             N+ GS+ C C                            P  P       + P  P  R 
Sbjct: 1108 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1167

Query: 1132 PER---------RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA 1182
            P           R  C+        C   LA   +T+ +CCC  G GWG+ CR       
Sbjct: 1168 PSTPRQGPVGSGRRECYFDTAAPDACDNILARN-VTWQECCCTVGEGWGSGCRI------ 1220

Query: 1183 GSHCP-TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRCVPRPGGA 1235
               CP T  +E  S        L   P  + S   D DEC+      C SG CV    G 
Sbjct: 1221 -QQCPGTETAEYQSLCPHGRGYLA--PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1277

Query: 1236 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1295
             C C  G+     R  C+D DEC +       C+  RCVNT GS+ C C+          
Sbjct: 1278 SCYCSNGYYYHTQRLECIDNDECADEEP---ACEGGRCVNTVGSYHCTCEPPLVLDGSQR 1334

Query: 1296 ACV 1298
             CV
Sbjct: 1335 RCV 1337



 Score =  508 bits (1307), Expect = e-143
 Identities = 393/1255 (31%), Positives = 515/1255 (41%), Gaps = 231/1255 (18%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 448  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 504

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 505  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 556

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 557  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 602

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 603  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 653

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 654  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 703

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 704  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 762

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 763  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 821

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 822  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 877

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 878  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 936

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 937  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 995

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 996  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 1053

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 1054 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1110

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1111 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1170

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1171 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1230

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1231 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1286

Query: 1027 YDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVD- 1084
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S E   +D 
Sbjct: 1287 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD 1346

Query: 1085 ---------------------------EC---------QDPAAC---------------- 1092
                                       EC          D A C                
Sbjct: 1347 NLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLR 1406

Query: 1093 -------RPGRCVNLPGSYRCECRPPWVPGPSGRDCQ----LPESPAERAPERRDVCWSQ 1141
                   RPG    LP  Y  +  PP+   P G +      LP  P    P         
Sbjct: 1407 PPAYSPPRPGG-FGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPP--------- 1456

Query: 1142 RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP-TSQSESNSFWDTS 1200
             G       P   P     D     G  +G    P PP G G+  P  S+    SF +  
Sbjct: 1457 -GPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-GPGTRWPYRSRDTRRSFPEPE 1513

Query: 1201 PLLLGKPPRD--------EDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDAS 1248
                 +PP          E   E +++EC     C +GRCV  P G  C C  G++LD +
Sbjct: 1514 -----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMT 1568

Query: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
            R  CVDI+EC E      LC + RC+NT GSFRC+C+ GFA +     C P R R
Sbjct: 1569 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPR 1623



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1146 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1195
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 296  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 353

Query: 1196 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1251
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 354  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 395

Query: 1252 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 396  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 449



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1425 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1474

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1475 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1526

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1527 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1583

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1584 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1622


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  468 bits (1204), Expect = e-131
 Identities = 321/1010 (31%), Positives = 427/1010 (42%), Gaps = 146/1010 (14%)

Query: 335  GEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            G     CP G+     T  C+D++EC +   C  G C N  GSY C C PG  L PS T 
Sbjct: 745  GSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803

Query: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA--- 450
            C+      K  C+  +  E +C+  L     R  CC ++G AWG+ C+RC  D   A   
Sbjct: 804  CL---DSTKGTCWLKIQ-ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF 859

Query: 451  ----------------FKEICPAGKGYHILTSHQTLTIQGES-DFSLFLHPDGPPKPQQL 493
                            F  +CP G+  +   S +    +G   D S  L  D   +P  L
Sbjct: 860  ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL 919

Query: 494  PESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPT-ATTTPARPYPELISRPS--PPT 550
                         E+E GVT       +               A P PE +   S  P  
Sbjct: 920  RWD----------EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969

Query: 551  MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQ 610
            + +   D    R   +       + +EC++   +C HG C      + C C  G+    Q
Sbjct: 970  LGFASRDFLSGRPFYK-------DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022

Query: 611  HRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLC 670
             R C D++EC   P   G+G C+NT GS+ C C  GY        ++C+D++ECA+  L 
Sbjct: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML-MKNCMDVDECARDPLL 1081

Query: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIA 729
              GG C N  G YKC C PG+ L A +   CEDIDEC      CP G+C N  G+F+C +
Sbjct: 1082 CRGGTCTNTDGSYKCQCPPGHELTA-KGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-S 1139

Query: 730  CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788
            C  G++S      C D+NEC   +      C N  GS+RC+C QGY+  PDGR+C DVDE
Sbjct: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDE 1199

Query: 789  CEAGD-VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNG 846
            CE    VCD G C+N PG  +C C  G+  + D   C D+DECD  P  C+ GDC NT G
Sbjct: 1200 CEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKG 1259

Query: 847  SYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ-DQ 904
            S+ C C  G+ +  G   C D+DEC      C  H +C N+ GS+ C C  G+     + 
Sbjct: 1260 SFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG-AGWGDHCEIYPCPVYS 963
            H  +E     H+  C    D    C +V  +      C C  G AG G  CE        
Sbjct: 1320 HDLDECVSQEHR--CSPRGD----CLNVPGS----YRCTCRQGFAGDGFFCE-------- 1361

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
                                         D DEC     ++C  G+C+N   GY C C+ 
Sbjct: 1362 -----------------------------DRDEC-AENVDLCDNGQCLNAPGGYRCECEM 1391

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDV 1083
            GF    +   C DVDEC   + C  G CEN  G +RC C    E       C      D+
Sbjct: 1392 GFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-----TDI 1446

Query: 1084 DECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQ-- 1141
            +EC DP  C  G C+N PGSY C C   +   PSG  C            R   C+ +  
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGC---------VDTRAGNCFLETH 1497

Query: 1142 -RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFW 1197
             RG+ G+      G  +T   CCC  GR WG  C  CP      +   CP  +       
Sbjct: 1498 DRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE------- 1550

Query: 1198 DTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARC 1252
                   G  P       ED DEC+     C  G CV   G   CECP G+ L      C
Sbjct: 1551 -------GFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC 1603

Query: 1253 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1302
             DIDEC   +    +C    C NT G++ CVC A + +      C+  R+
Sbjct: 1604 EDIDEC---STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRK 1650



 Score =  444 bits (1143), Expect = e-124
 Identities = 350/1170 (29%), Positives = 465/1170 (39%), Gaps = 243/1170 (20%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQED-CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335
            G CF    P + C  + L GL   +  CC ++G AWG   C  CP        +P P   
Sbjct: 185  GPCFGQVGP-EGC-QHQLTGLVCTKALCCATVGRAWGLP-CELCPA-------QPHP--- 231

Query: 336  EVGADCPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
                 C +G+   +++  CQD++EC A+PG+C+ G C+N  GS+ C CP GH L  S   
Sbjct: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286

Query: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAAF 451
            C   +      CF ++    +C   L    TR+ CCC  G+ W A    + CP  G+  F
Sbjct: 287  C---EDYRAGACFSVLFGG-RCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEF 342

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
            +++C   +   +L  H  L   G   F    +  GPP        P++  P     + RG
Sbjct: 343  QQLC--AQRLPLLPGHPGL-FPGLLGFGS--NGMGPPL------GPARLNP--HGSDARG 389

Query: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQ 571
            + +  P +   ++  +    T    R +  L            LP     R    +  TQ
Sbjct: 390  IPSLGPGNS--NIGTATLNQTIDICRHFTNLCLNGR------CLPTPSSYRCECNVGYTQ 441

Query: 572  -----VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCG 626
                   + DEC    + C HG+CV  P  Y C C PG+++ P  + CVDV+EC      
Sbjct: 442  DVRGECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499

Query: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686
               G C+NT GS+ C CN G+ L     G++CVD NECA   +C + G C+N  G + C 
Sbjct: 500  CHLGRCVNTEGSFQCVCNAGFEL--SPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCL 556

Query: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745
            C PG+ L A     C DIDEC+ P  C +G C N  GSF+C  C  G      G  C D 
Sbjct: 557  CKPGF-LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLGGLAVGTDGRVCVDT 614

Query: 746  N------------ECAE--------------------GSPC------------------- 754
            +             CA                     G PC                   
Sbjct: 615  HVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGL 674

Query: 755  --------------SPGWCEN-----LPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-V 794
                           P  C N     L GS+RC C  GY     G+ C DVDEC     +
Sbjct: 675  GITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLL 734

Query: 795  CDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQ 854
            CDNG C N+PGS+ C C  G+H  +D   C+D+DEC   + C+ G C N  GSY C C  
Sbjct: 735  CDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGP 793

Query: 855  GHRL-VGGRKCQD---------------------------------------IDECSQDP 874
            G RL   G  C D                                        + C  DP
Sbjct: 794  GSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDP 853

Query: 875  SLCLPH------------------GACKN-----LQGSYVCVCDEGFTPTQDQHGCEEVE 911
            +                       G C N       GS+ C C EG         C +V 
Sbjct: 854  ACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV- 912

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLC 971
                 + C+L +D+   C   L        CCCS+GA WG  CE   CP   S EF SLC
Sbjct: 913  ---RLEPCFLRWDEDE-CGVTLPGKYRMDVCCCSIGAVWGVECE--ACPDPESLEFASLC 966

Query: 972  PDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNL 1031
            P G G+   + +   G P ++D++EC +F   +C  G C NT   + C C  GF  D   
Sbjct: 967  PRGLGFASRDFL--SGRPFYKDVNECKVFPG-LCTHGTCRNTVGSFHCACAGGFALDAQE 1023

Query: 1032 LECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYS-PAQRQCLSPEEMDVDEC-QD 1088
              C D+DEC +    C  G C NT G + C C P  E      + C     MDVDEC +D
Sbjct: 1024 RNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNC-----MDVDECARD 1078

Query: 1089 PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC 1148
            P  CR G C N  GSY+C+C P       G  C           E  D C      DG+C
Sbjct: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC-----------EDIDEC---SLSDGLC 1124

Query: 1149 AGPLAGPALTFDDCCCRQG------RGWGAQCRPCPPRGAGS--HCPTSQSESNSFWDTS 1200
                    +    C C  G      R        C  +  G   HC  ++          
Sbjct: 1125 PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQG 1184

Query: 1201 PLLL--GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDEC 1258
              L+  G+   D D  EE+   C    G C   PGG  C C  GF        CVD+DEC
Sbjct: 1185 YSLMPDGRACADVDECEENPRVCD--QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC 1242

Query: 1259 RELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288
             +LN    +C    C NT GSF C C+ G+
Sbjct: 1243 -DLNPH--ICLHGDCENTKGSFVCHCQLGY 1269



 Score =  388 bits (997), Expect = e-107
 Identities = 256/806 (31%), Positives = 349/806 (43%), Gaps = 147/806 (18%)

Query: 589  ECVPGP--PDYSCHCN---PGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHC 643
            E  P P  PDY   C    PG+ +       +D++EC   P     GIC+N  GS+ C C
Sbjct: 1689 EACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCEC 1748

Query: 644  NRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE 702
              G+  +      +C D++EC ++   C     CIN PG Y+C C  GY+L  S    C 
Sbjct: 1749 PAGFNYNSIL--LACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL--SPGGACV 1804

Query: 703  DIDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCE 760
              +ECR+ P+ C  G C +  GS+ C+ C  G+++      C D++EC +  PC  G C+
Sbjct: 1805 GRNECREIPNVCSHGDCMDTEGSYMCL-CHRGFQASADQTLCMDIDEC-DRQPCGNGTCK 1862

Query: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYHLS 818
            N+ GS+ C C  G+    +G  C+D DEC    G VC  G C NT GSF C C  G+ L+
Sbjct: 1863 NIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELT 1921

Query: 819  RDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLC 877
             D  +C D +EC      C+ G C N  GS+RC+CP G + V    C DIDECS++P+LC
Sbjct: 1922 ADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ-VQSDHCIDIDECSEEPNLC 1980

Query: 878  LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
            L  G C N  GS+ C+C  GF  + + H C +  Q      C+  F+    C    A N 
Sbjct: 1981 L-FGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSF----CFTRFEAGK-CSVPKAFNT 2034

Query: 938  TQQECCCSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
            T+  CCCS   G GWGD CE+  CP   SA F  LCP G G     +       +  D++
Sbjct: 2035 TKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPD------DSREDVN 2086

Query: 996  ECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTR 1055
            EC      +C  G CVNT   + C C  G+  D   + CVD DEC     C  G C N  
Sbjct: 2087 ECAE-NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVI 2145

Query: 1056 GGYRCA--------------------------------------CTPPAEYSPAQRQCLS 1077
            GG+ CA                                      CT PA Y+  +   + 
Sbjct: 2146 GGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205

Query: 1078 PEEMDVDEC---QDPAACRPGRCVNLPGSYRCECRPPWVPGP------------------ 1116
                DVDEC   Q     R   C NL G++ C C P   P P                  
Sbjct: 2206 ---RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDL 2262

Query: 1117 --SGR----------DCQLPESPAERAPERRDV----CWSQRGEDGMCAGPLAGPALTFD 1160
              +GR          DC     P+    E  D+    C+++  +    +   +  A+T  
Sbjct: 2263 CVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRA 2322

Query: 1161 DCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEED 1217
            +CCC  GRGWG +C  CP  G  ++   CP     +                   +   D
Sbjct: 2323 ECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT-------------------AEGRD 2363

Query: 1218 SDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR-GLLCKSE 1271
             DECR     C  G C+   G   C C  G+  DA+   C+D+DEC ++ +    LCK  
Sbjct: 2364 VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCK-- 2421

Query: 1272 RCVNTSGSFRCVCKAGFARSRPHGAC 1297
               NT GSF C C  G+        C
Sbjct: 2422 ---NTKGSFLCSCPRGYLLEEDGRTC 2444



 Score =  377 bits (967), Expect = e-104
 Identities = 264/786 (33%), Positives = 355/786 (45%), Gaps = 100/786 (12%)

Query: 570  TQVTETDECRLNQNIC-GHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CG 626
            T  ++ DEC +  + C  H  C+  P  +SC C PG+        C D++EC ++   C 
Sbjct: 1276 TGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE--CHDLDECVSQEHRCS 1333

Query: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686
            P RG C+N  GSY C C +G+       G  C D +ECA+     D G C+N PG Y+C 
Sbjct: 1334 P-RGDCLNVPGSYRCTCRQGF----AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE 1388

Query: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745
            C  G+         C+D+DEC   + C  G CEN PG F+CI C  GY   +GGG C D+
Sbjct: 1389 CEMGFDPTEDHR-ACQDVDECAQGNLCAFGSCENLPGMFRCI-CNGGYELDRGGGNCTDI 1446

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV--DEC--EAGDVCDNGI-C 800
            NECA+   C  G C N PGS+ C+C Q +   P G  C+D     C  E  D  D+GI C
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISC 1506

Query: 801  SNTPG----SFQCQCL---------------------------SGYHLSRDRSHCEDIDE 829
            S   G       C C                             G+  +R     EDIDE
Sbjct: 1507 SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566

Query: 830  C-DFPAACIGGDCINTNGSYRCLCPQGHRLVGG-RKCQDIDECSQDPSLCLPHGACKNLQ 887
            C + P  C GGDC+NT GS++C CP G+ L    R C+DIDECS    +C P G C N  
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTL 1625

Query: 888  GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS-- 945
            G+Y CVC   +      + C ++     K  C+ +++ T  C + LA NVT++ CCCS  
Sbjct: 1626 GNYTCVCPAEYLQVNGGNNCMDMR----KSVCFRHYNGT--CQNELAFNVTRKMCCCSYN 1679

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPD-GKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004
            +G  W   CE  P P+  S ++  LC +   G+  D   ++ G P   DIDEC    + I
Sbjct: 1680 IGQAWNRPCEACPTPI--SPDYQILCGNQAPGFLTD---IHTGKPL--DIDECGEIPA-I 1731

Query: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNC-RNGVCENTRGGYRCAC 1062
            C  G C+N    + C C  GF Y+  LL C DVDEC   ES C +N  C N  G YRC C
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791

Query: 1063 TPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDC 1121
            T   + SP    C+       +EC++ P  C  G C++  GSY C C   +        C
Sbjct: 1792 TRGYKLSPG-GACVGR-----NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLC 1845

Query: 1122 QLPESPAERAPERRDVCWSQRGEDGMCAGP-----LAGPALTFDDCCCRQGRGWGAQCRP 1176
             +     +R P     C +  G       P       G  + FD+C    G+     CR 
Sbjct: 1846 -MDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQ----VCR- 1899

Query: 1177 CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAV 1236
                    HC  +    +        L        D++E  S    C+ G C    G   
Sbjct: 1900 ------FGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953

Query: 1237 CECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGA 1296
            C CP GFQ+ +    C+DIDEC E      LC    C N+ GSF+C+C  GF  S     
Sbjct: 1954 CICPPGFQVQSD--HCIDIDECSE---EPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHR 2008

Query: 1297 CVPQRR 1302
            C   R+
Sbjct: 2009 CFDTRQ 2014



 Score =  375 bits (962), Expect = e-103
 Identities = 332/1199 (27%), Positives = 462/1199 (38%), Gaps = 294/1199 (24%)

Query: 277  GRCFQDTLPKQP----CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--P 330
            G CF +T  +      C +    G+T+   CC S+G AWG + C  CP    T  +   P
Sbjct: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCC-SLGRAWG-NPCELCPMANTTEYRTLCP 1547

Query: 331  G-----PVR---------------------------GEVGADCPQGYKRLNSTH-CQDIN 357
            G     P R                           G    +CP GY     T  C+DI+
Sbjct: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607

Query: 358  ECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQ 416
            EC+   G+C  G C N  G+Y CVCP  +        C+  +   KS+CFR  +    CQ
Sbjct: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR---KSVCFRHYNGT--CQ 1662

Query: 417  HPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474
            + L   +TR++CCCS  +G+AW   C+ CPT          P    Y IL  +Q      
Sbjct: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPT----------PISPDYQILCGNQA----- 1707

Query: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534
               F   +H   P    +  E P+         +      + P     +       +   
Sbjct: 1708 -PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN-------SILL 1759

Query: 535  PARPYPELISRPSPPTMRWFLPDLPPS-----RSAVEIAPTQV-TETDECRLNQNICGHG 588
                  E  SR SP        ++P S         +++P       +ECR   N+C HG
Sbjct: 1760 ACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHG 1819

Query: 589  ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR------------------- 629
            +C+     Y C C+ G+++      C+D++EC+ +PCG G                    
Sbjct: 1820 DCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVT 1879

Query: 630  ---------------------GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPH 668
                                 G C+NT GS++C C  G+ L   A G++CVD NEC    
Sbjct: 1880 HNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELT--ADGKNCVDTNECLSLA 1937

Query: 669  LCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKC 727
                 G C N  G ++C C PG+++++     C DIDEC  +P+ C  G C N PGSF+C
Sbjct: 1938 GTCLPGTCQNLEGSFRCICPPGFQVQSDH---CIDIDECSEEPNLCLFGTCTNSPGSFQC 1994

Query: 728  IACQPGY-RSQGGGACRDVNECA-----EGSPCS-------------------PGW---C 759
            + C PG+  S  G  C D  +       E   CS                    GW   C
Sbjct: 1995 L-CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC 2053

Query: 760  ENLP----GSFR--CTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCL 812
            E  P     +F+  C    G  P PD  S  DV+EC E   VC NG+C NT GSF+C+C 
Sbjct: 2054 ELCPQEGSAAFQELCPFGHGAVPGPDD-SREDVNECAENPGVCTNGVCVNTDGSFRCECP 2112

Query: 813  SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQ 872
             GY L     +C D DEC     C  G C N  G + C C  G        C+DIDECS 
Sbjct: 2113 FGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSL 2172

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ-PHHKKECYLNFDDTVFCDS 931
            +P LC     C N +GSY+C C  G+T  +D   C +V++    +++C+    +   C +
Sbjct: 2173 NPLLCAFR--CHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGME---CKN 2227

Query: 932  VLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAH 991
            ++ T      C C  G        + P P             G+G T DN         H
Sbjct: 2228 LIGTFA----CVCPPG--------MRPLP-----------GSGEGCTDDNE-------CH 2257

Query: 992  RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE-----------C 1040
               D        +C  G+CVNT   + C C +GF     L EC D+ +           C
Sbjct: 2258 AQPD--------LCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMC 2309

Query: 1041 LDESNCRNGV------CENTRG-GYRCACTPPAEYSPAQRQC-----LSPEEMDVDECQD 1088
               S+    V      C   RG G RC   P    S  ++ C      + E  DVDEC+ 
Sbjct: 2310 RSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRM 2369

Query: 1089 PA-ACRPGRCVNLPGSYRCECRPPWVPGPSGRDC-------QLPESPAERAPERRD--VC 1138
             A  C  G C+N  GS+RC C+  + P  +   C       Q+P+         +   +C
Sbjct: 2370 LAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLC 2429

Query: 1139 WSQRG----EDGMCAGPLAGPALTFDDCCCRQGRGW-------GAQCRPCPPRGAGSHCP 1187
               RG    EDG     L       D+C  RQ           GA    CPP     H  
Sbjct: 2430 SCPRGYLLEEDGRTCKDL-------DECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH-- 2480

Query: 1188 TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC------VSGRCVPRPGGAVCECPG 1241
                                      +  D+DEC          G C   PG   CEC  
Sbjct: 2481 -------------------------QACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQ 2515

Query: 1242 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300
            GF L +S   C D++EC   ++    C+   C N  G +RC C  GF +      CV +
Sbjct: 2516 GFTLVSSGHGCEDVNECDGPHR----CQ-HGCQNQLGGYRCSCPQGFTQHSQWAQCVDE 2569



 Score =  338 bits (867), Expect = 2e-92
 Identities = 240/800 (30%), Positives = 330/800 (41%), Gaps = 154/800 (19%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            +T+EC      C  G C      + C C PG++    H  C+D++EC  EP     G C 
Sbjct: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--------------------------CAKP 667
            N+ GS+ C C  G+ L     G  C D  +                          C+K 
Sbjct: 1987 NSPGSFQCLCPPGFVL--SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKR 2044

Query: 668  HLCGDGGFCINFPGH----YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722
               G G  C   P      ++  C  G+          ED++EC + P  C +G C N  
Sbjct: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTD 2104

Query: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781
            GSF+C  C  GY     G  C D +EC+ G PC  G C N+ G F C CA G+ P     
Sbjct: 2105 GSFRC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-M 2162

Query: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACI--G 838
            +C D+DEC    +     C NT GS+ C C +GY L  D + C D+DEC D    C   G
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222

Query: 839  GDCINTNGSYRCLCPQGHRLV--GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
             +C N  G++ C+CP G R +   G  C D +EC   P LC+ +G C N  GS+ C CDE
Sbjct: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDE 2281

Query: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHC 954
            GF P+     C ++ Q      C+     T+ C S+ +++  VT+ ECCC  G GWG  C
Sbjct: 2282 GFQPSPTLTECHDIRQG----PCFAEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336

Query: 955  EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014
            E+  CP+  ++ +  LCP G GYT +           RD+DEC +  + +C  G+C+N+ 
Sbjct: 2337 EL--CPLPGTSAYRKLCPHGSGYTAEG----------RDVDECRML-AHLCAHGECINSL 2383

Query: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
              + C+C+ G+  D     C+D+DEC         +C+NT+G + C+C          R 
Sbjct: 2384 GSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRT 2443

Query: 1075 CLSPEE----------------------------------MDVDECQ-DPAACRP-GRCV 1098
            C   +E                                   D DEC   P  C   G C 
Sbjct: 2444 CKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCH 2503

Query: 1099 NLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALT 1158
            N PGS+RCEC   +    SG  C+                     +   C GP       
Sbjct: 2504 NTPGSFRCECHQGFTLVSSGHGCE---------------------DVNECDGP-----HR 2537

Query: 1159 FDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1218
                C  Q  G+   C    P+G   H   +Q       D +   L  P           
Sbjct: 2538 CQHGCQNQLGGYRCSC----PQGFTQHSQWAQCV-----DENECALSPP----------- 2577

Query: 1219 DECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1278
                C S  C    GG  C CP GF  D +   C ++DEC    +RG    S  C NT G
Sbjct: 2578 ---TCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC--AGRRGPC--SYSCANTPG 2630

Query: 1279 SFRCVCKAGFARSRPHGACV 1298
             F C C  G+ R+   G CV
Sbjct: 2631 GFLCGCPQGYFRA-GQGHCV 2649



 Score =  237 bits (605), Expect = 5e-62
 Identities = 177/540 (32%), Positives = 226/540 (41%), Gaps = 91/540 (16%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGPGRGI- 631
            + DEC LN  +C    C      Y C C  GY        C DV+EC + +     RG+ 
Sbjct: 2166 DIDECSLNPLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGME 2224

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690
            C N  G++ C C  G R   G+G   C D NEC A+P LC +G  C+N  G ++C+C  G
Sbjct: 2225 CKNLIGTFACVCPPGMRPLPGSG-EGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEG 2282

Query: 691  YRLKASRPPVCEDIDE-----------CRDPSS-----------CPDGK-----CE--NK 721
            ++   +    C DI +           CR  SS           C  G+     CE    
Sbjct: 2283 FQPSPTLTE-CHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPL 2341

Query: 722  PGSFKCIACQP---GYRSQGGGACRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPA 777
            PG+       P   GY ++G    RDV+EC      C+ G C N  GSFRC C  GY P 
Sbjct: 2342 PGTSAYRKLCPHGSGYTAEG----RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPD 2397

Query: 778  PDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI 837
                +CLD+DEC         +C NT GSF C C  GY L  D   C+D+DEC       
Sbjct: 2398 ATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC 2457

Query: 838  GGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
               C+NT G++ C CP G      + C D DECS  P  C  HG C N  GS+ C C +G
Sbjct: 2458 QFLCVNTVGAFTCRCPPGFTQ-HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQG 2516

Query: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957
            FT     HGCE+V +      C                   Q  C   LG         Y
Sbjct: 2517 FTLVSSGHGCEDVNECDGPHRC-------------------QHGCQNQLGG--------Y 2549

Query: 958  PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017
             C           CP  +G+TQ +           D +EC L     C    C NT  G+
Sbjct: 2550 RCS----------CP--QGFTQHSQWAQCV-----DENECAL-SPPTCGSASCRNTLGGF 2591

Query: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
             C C  GF +D  L  C +VDEC       +  C NT GG+ C C P   +   Q  C+S
Sbjct: 2592 RCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGC-PQGYFRAGQGHCVS 2650



 Score =  188 bits (478), Expect = 3e-47
 Identities = 124/416 (29%), Positives = 178/416 (42%), Gaps = 88/416 (21%)

Query: 559  PPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            PP    +  +    T+ +EC    ++C +G CV     + C C+ G++  P    C D+ 
Sbjct: 2237 PPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296

Query: 619  E--CEAEP---------------------CGPGRG------------------------- 630
            +  C AE                      CG GRG                         
Sbjct: 2297 QGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSG 2356

Query: 631  ---------------------ICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PH 668
                                  C+N+ GS+ CHC  GY     A   +C+D++EC++ P 
Sbjct: 2357 YTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYT--PDATATTCLDMDECSQVPK 2414

Query: 669  LCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCI 728
             C     C N  G + C+C  GY L+      C+D+DEC          C N  G+F C 
Sbjct: 2415 PC--TFLCKNTKGSFLCSCPRGYLLEED-GRTCKDLDECTSRQHNCQFLCVNTVGAFTC- 2470

Query: 729  ACQPGYRSQGGGACRDVNEC-AEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV 786
             C PG+ +Q   AC D +EC A+  PC + G C N PGSFRC C QG+     G  C DV
Sbjct: 2471 RCPPGF-TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDV 2529

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTN 845
            +EC+    C +G C N  G ++C C  G+      + C D +EC   P  C    C NT 
Sbjct: 2530 NECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTL 2588

Query: 846  GSYRCLCPQG---HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
            G +RC+CP G    + +GG  CQ++DEC+     C    +C N  G ++C C +G+
Sbjct: 2589 GGFRCVCPSGFDFDQALGG--CQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGY 2640



 Score =  178 bits (451), Expect = 3e-44
 Identities = 202/802 (25%), Positives = 273/802 (34%), Gaps = 220/802 (27%)

Query: 623  EPCGPGR-------GICMNT---GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HL 669
            E  GPGR       GI       G  ++ +C  G+R   G         ++C  P     
Sbjct: 38   EAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGR--------SQCVVPICRRA 89

Query: 670  CGDGGFCINFPGHYKCNCYPGYRLKA---SRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726
            CG+G FC        C C  G    +   SR   C     C +  +C    C        
Sbjct: 90   CGEG-FCSQ---PNLCTCADGTLAPSCGVSRGSGCSV--SCMNGGTCRGASC-------- 135

Query: 727  CIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
               CQ GY     G       C  G  C  P  C  + G     C + Y   P     + 
Sbjct: 136  --LCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQ-VG 192

Query: 786  VDECE---AGDVCDNGICSNTPG---SFQCQ--------CLSGYHLSRDRSHCEDIDECD 831
             + C+    G VC   +C  T G      C+        C  G+  +     C+D+DEC 
Sbjct: 193  PEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ 252

Query: 832  -FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGS 889
              P  C GG C+N  GS+ C CP GHRL      C+D              GAC ++   
Sbjct: 253  AVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-----------GACFSVLFG 301

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949
              C  D                                     LA + T+++CCC  G  
Sbjct: 302  GRCAGD-------------------------------------LAGHYTRRQCCCDRGRC 324

Query: 950  WGDHCEIYPCPVYSSAEFHSLC---------------------------PDGKGYTQDNN 982
            W        CP   S EF  LC                           P G      + 
Sbjct: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384

Query: 983  IVNYGIPA-------------HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG 1029
                GIP+             ++ ID C  F + +C  G+C+ T   Y C C  G+  D 
Sbjct: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHF-TNLCLNGRCLPTPSSYRCECNVGYTQDV 443

Query: 1030 NLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QD 1088
               EC+DVDEC   S C +G C N  G Y C C P  + +P ++ C     +DVDEC   
Sbjct: 444  R-GECIDVDEC-TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQAC-----VDVDECIVS 496

Query: 1089 PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG----- 1143
               C  GRCVN  GS++C C   +   P G++C      A        VC ++ G     
Sbjct: 497  GGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCL 556

Query: 1144 -EDGMCAGPLAGPALTFDDC-----C---------------CRQGRGWGAQCRPCPPRGA 1182
             + G    P     +  D+C     C               C  G   G   R C     
Sbjct: 557  CKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHV 616

Query: 1183 GSHC-------------PTSQSESNSFWDTSPLLLGKPPR---DEDSSE----------- 1215
             S C             P + ++S           G+P +    +DS+E           
Sbjct: 617  RSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGI 676

Query: 1216 ----EDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGL 1266
                 D +EC      C +G C    G   C C  G++  AS   C D+DEC  LN   L
Sbjct: 677  TTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDEC-ALN--SL 733

Query: 1267 LCKSERCVNTSGSFRCVCKAGF 1288
            LC +  C N+ GS+ C C  GF
Sbjct: 734  LCDNGWCQNSPGSYSCSCPPGF 755



 Score =  171 bits (432), Expect = 5e-42
 Identities = 229/909 (25%), Positives = 293/909 (32%), Gaps = 306/909 (33%)

Query: 583  NICG---HGECVPG----PPDYSC-------HCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
            N+CG   H  C PG    P    C        C  G+ S P    C D     A  CG  
Sbjct: 58   NVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTL--APSCGVS 115

Query: 629  RGI-----CMNTGG--SYNCHCNRGYRLHVGA----------GGRSCVDLNECA------ 665
            RG      CMN G     +C C +GY   V            GGR C+  N CA      
Sbjct: 116  RGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGR-CIGPNRCACVYGFM 174

Query: 666  --------------------------------KPHLCGDGGFCINFPGHYKCNCYPGYRL 693
                                            K   C   G     P    C   P    
Sbjct: 175  GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCEL-CPAQPHPCR 233

Query: 694  KASRPPV----CEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNE 747
            +   P +    C+D+DEC+  P  C  G C N  GSF C  C  G+R S    AC D   
Sbjct: 234  RGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHC-RCPVGHRLSDSSAACEDYRA 292

Query: 748  CAEGSPCSPGWCE-NLPGSF---RCTCAQG--YAPAPDGRSCLDVDECEAGDVCDNGI-- 799
             A  S    G C  +L G +   +C C +G  +A  P    C      E   +C   +  
Sbjct: 293  GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL 352

Query: 800  CSNTPGSFQCQCLSGYH-------LSRDRSHCED----------------------IDEC 830
                PG F      G +        +R   H  D                      ID C
Sbjct: 353  LPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC 412

Query: 831  -DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGS 889
              F   C+ G C+ T  SYRC C  G+      +C D+DEC+  P     HG C N+ G+
Sbjct: 413  RHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSP---CHHGDCVNIPGT 469

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQ-ECCCSLGA 948
            Y C C  GF  T  +  C +V+      EC ++      C      N     +C C+ G 
Sbjct: 470  YHCRCYPGFQATPTRQACVDVD------ECIVSGG---LCHLGRCVNTEGSFQCVCNAG- 519

Query: 949  GWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG 1008
                                 L PDGK     N              EC    S +C  G
Sbjct: 520  -------------------FELSPDGKNCVDHN--------------ECAT--STMCVNG 544

Query: 1009 KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP---- 1064
             C+N    + C CK GF        C+D+DEC     C NG C NT G +RC C      
Sbjct: 545  VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAV 604

Query: 1065 -----------------------------PAEYSPAQRQCLSPEEMDVDECQ-------- 1087
                                         P   + ++  C +P+    + CQ        
Sbjct: 605  GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSA 664

Query: 1088 ------------------------DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQL 1123
                                    DP  C  G C NL GSYRC C   +  G SG+DC  
Sbjct: 665  EFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDC-- 722

Query: 1124 PESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAG 1183
                        D C              A  +L  D+  C+     G+    CPP   G
Sbjct: 723  ---------TDVDEC--------------ALNSLLCDNGWCQNSP--GSYSCSCPP---G 754

Query: 1184 SHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC---RCVSGRCVPRPGGAVCECP 1240
             H          FW  + +             +D DEC    CVSG C    G   C+C 
Sbjct: 755  FH----------FWQDTEIC------------KDVDECLSSPCVSGVCRNLAGSYTCKCG 792

Query: 1241 GGFQLDASRARCVD---------IDECR-ELNQRGLLCKSERCVNTSGSF-----RC--- 1282
             G +LD S   C+D         I E R E+N +G   +SE C     ++     RC   
Sbjct: 793  PGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEID 852

Query: 1283 -VCKAGFAR 1290
              C  GFAR
Sbjct: 853  PACARGFAR 861



 Score =  135 bits (341), Expect = 2e-31
 Identities = 178/677 (26%), Positives = 234/677 (34%), Gaps = 166/677 (24%)

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726
            P++CG           +   C PG+R    R      I  CR   +C +G C        
Sbjct: 57   PNVCGS---------RFHAYCCPGWRTFPGRSQCVVPI--CR--RACGEGFCSQP----N 99

Query: 727  CIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFR---CTCAQGYAPAPDGRSC 783
               C  G  +   G  R       GS CS   C N  G+ R   C C +GY     G+  
Sbjct: 100  LCTCADGTLAPSCGVSR-------GSGCSVS-CMN-GGTCRGASCLCQKGYTGTVCGQPI 150

Query: 784  LDVDECEAGDVCDNGICSNTPGSFQCQCLSGY---HLSRD--RSHC------EDIDECDF 832
                 C+ G  C NG      G  +C C+ G+      RD     C      E       
Sbjct: 151  -----CDRG--CHNG--GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLT 201

Query: 833  PAACIGGDCINTNG---SYRC-LCP-QGHRLVGG-------RKCQDIDECSQDPSLCLPH 880
               C    C  T G      C LCP Q H    G         CQD+DEC   P LC   
Sbjct: 202  GLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLC-QG 260

Query: 881  GACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF---CDSVLATNV 937
            G+C N+ GS+ C C  G   +     CE+    +    C+      +F   C   LA + 
Sbjct: 261  GSCVNMVGSFHCRCPVGHRLSDSSAACED----YRAGACF----SVLFGGRCAGDLAGHY 312

Query: 938  TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
            T+++CCC  G  W        CP   S EF  LC                +P H  +   
Sbjct: 313  TRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL----------LPGHPGLFPG 362

Query: 998  ML-FGSE----------ICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN- 1045
            +L FGS           +   G      P        G    G       +D C   +N 
Sbjct: 363  LLGFGSNGMGPPLGPARLNPHGSDARGIPSLG----PGNSNIGTATLNQTIDICRHFTNL 418

Query: 1046 CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYR 1105
            C NG C  T   YRC C      +    Q +  E +DVDEC   + C  G CVN+PG+Y 
Sbjct: 419  CLNGRCLPTPSSYRCEC------NVGYTQDVRGECIDVDECTS-SPCHHGDCVNIPGTYH 471

Query: 1106 CECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCR 1165
            C C P +   P+ + C                                   +  D+C   
Sbjct: 472  CRCYPGFQATPTRQAC-----------------------------------VDVDECIVS 496

Query: 1166 QGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--- 1222
             G     +C        GS     Q   N+ ++ SP         +  +  D +EC    
Sbjct: 497  GGLCHLGRC----VNTEGSF----QCVCNAGFELSP---------DGKNCVDHNECATST 539

Query: 1223 -CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
             CV+G C+   G   C C  GF L      C+DIDEC    Q   +C +  C NT GSFR
Sbjct: 540  MCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC----QTPGICVNGHCTNTEGSFR 595

Query: 1282 CVCKAGFARSRPHGACV 1298
            C C  G A       CV
Sbjct: 596  CQCLGGLAVGTDGRVCV 612



 Score =  117 bits (292), Expect = 9e-26
 Identities = 159/598 (26%), Positives = 201/598 (33%), Gaps = 109/598 (18%)

Query: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE--NLPGS-FRCTCAQGYAPAPDG 780
            ++  + C  G + +  GA             SPG  +  N+ GS F   C  G+   P G
Sbjct: 19   AWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFP-G 77

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GG 839
            RS   V  C     C  G CS       C C  G         C          +C+ GG
Sbjct: 78   RSQCVVPICRRA--CGEGFCSQPN---LCTCADGTLAPS----CGVSRGSGCSVSCMNGG 128

Query: 840  DCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
             C   +    CLC +G+    G  C Q I  C +    C   G C    G   C C  GF
Sbjct: 129  TCRGAS----CLCQKGYT---GTVCGQPI--CDRG---CHNGGRCI---GPNRCACVYGF 173

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
               Q        E+ +    C+           +     T+  CC ++G  WG  CE+ P
Sbjct: 174  MGPQ-------CERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
               +         P  +G+     I N    A +D+DEC      +C+ G CVN    + 
Sbjct: 227  AQPH---------PCRRGF-----IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFH 271

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
            C C  G     +   C D          R G C +   G RCA      Y+  +RQC   
Sbjct: 272  CRCPVGHRLSDSSAACEDY---------RAGACFSVLFGGRCAGDLAGHYT--RRQCCCD 320

Query: 1079 EEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQL----------PESPA 1128
                      P  C P           C  R P +PG  G    L          P  PA
Sbjct: 321  RGRCWAAGPVPELCPPRGSNEF--QQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPA 378

Query: 1129 ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC-----CCRQGRGWGAQCRPCPPRGAG 1183
               P   D         G      A    T D C      C  GR        C P  + 
Sbjct: 379  RLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR--------CLPTPSS 430

Query: 1184 SHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR---CVSGRCVPRPGGAVCECP 1240
              C  +   +               +D      D DEC    C  G CV  PG   C C 
Sbjct: 431  YRCECNVGYT---------------QDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCY 475

Query: 1241 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
             GFQ   +R  CVD+DEC      G LC   RCVNT GSF+CVC AGF  S     CV
Sbjct: 476  PGFQATPTRQACVDVDEC---IVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCV 530



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 19/104 (18%)

Query: 359 CAMPGVCRHGDCLNNPGSYRCVCPP----------GHSLGPSRTQCI-------ADKPEE 401
           C   G CR   CL   G    VC            G  +GP+R  C+        ++   
Sbjct: 124 CMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYR 183

Query: 402 KSLCFRLVSPEHQCQHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444
              CF  V PE  CQH LT  + T+ LCC +VG+AWG  C+ CP
Sbjct: 184 TGPCFGQVGPE-GCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 71/296 (23%), Positives = 84/296 (28%), Gaps = 109/296 (36%)

Query: 1021 CKQGFYYDGNLLECVDVD---------------ECLDESNCRNGVCENTRGGYRCACTPP 1065
            C +GF    NL  C D                  C++   CR   C   +G     C  P
Sbjct: 90   CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQP 149

Query: 1066 AEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPE 1125
                                C D      GRC+   G  RC C    V G  G  C+   
Sbjct: 150  I-------------------C-DRGCHNGGRCI---GPNRCAC----VYGFMGPQCE--- 179

Query: 1126 SPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH 1185
                    R   C+ Q G +G C   L G   T   CC   GR WG    PC        
Sbjct: 180  -----RDYRTGPCFGQVGPEG-CQHQLTGLVCTKALCCATVGRAWGL---PC------EL 224

Query: 1186 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1245
            CP                                          P P      C  GF  
Sbjct: 225  CPAQ----------------------------------------PHP------CRRGFIP 238

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301
            +     C D+DEC+ +     LC+   CVN  GSF C C  G   S    AC   R
Sbjct: 239  NIHTGACQDVDECQAVPG---LCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 12/93 (12%)

Query: 304  CGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-THCQDINECAM- 361
            C  +    G  +C    Q Q  G +            CPQG+ + +    C D NECA+ 
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR----------CSCPQGFTQHSQWAQCVDENECALS 2575

Query: 362  PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            P  C    C N  G +RCVCP G     +   C
Sbjct: 2576 PPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 59/201 (29%), Positives = 71/201 (35%), Gaps = 51/201 (25%)

Query: 20  AAGLLALLLLL---LLLLLGLGGRVEG-----GPAGERGAGGGGAL-----ARERFKVVF 66
           A G LA LLL    LL + G  GR +G     GP   R  G  G L        RF    
Sbjct: 9   ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC 68

Query: 67  AP-------------VICKRTCLKGQCRD-------------SC--QQGSNMTLIGENG- 97
            P              IC+R C +G C               SC   +GS  ++   NG 
Sbjct: 69  CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG 128

Query: 98  --HSTDTLTGSGFRVVVCPLP-----CMNGGQCSSRNQCLCPPDFTGRFCQ--VPAGGAG 148
                  L   G+   VC  P     C NGG+C   N+C C   F G  C+     G   
Sbjct: 129 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188

Query: 149 GGTGGSGPGLSRTGALSTGAL 169
           G  G  G     TG + T AL
Sbjct: 189 GQVGPEGCQHQLTGLVCTKAL 209



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 22/54 (40%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 334  RGEVGADCPQGYK-RLNSTHCQDINECAMPG--VCRHGDCLNNPGSYRCVCPPG 384
            +G     C  GY  R  +T C D++EC + G     H  CLN PGS+ C C PG
Sbjct: 1258 KGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG 1311



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 3/75 (4%)

Query: 333  VRGEVGADCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            V G     C QG+   +   C+D +ECA    +C +G CLN PG YRC C  G       
Sbjct: 1341 VPGSYRCTCRQGFAG-DGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDH 1399

Query: 392  TQC-IADKPEEKSLC 405
              C   D+  + +LC
Sbjct: 1400 RACQDVDECAQGNLC 1414



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 41/163 (25%), Positives = 61/163 (37%), Gaps = 35/163 (21%)

Query: 251  ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310
            E +A  Q L P    + P P   +      +D      C  NP  G+     C  + G+ 
Sbjct: 2059 EGSAAFQELCPFGHGAVPGPDDSR------EDV---NECAENP--GVCTNGVCVNTDGSF 2107

Query: 311  WGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQG----------------YKRLNST 351
                +C +CP    L +TG+         VG  C QG                ++     
Sbjct: 2108 ----RC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162

Query: 352  HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
             C+DI+EC++  +     C N  GSY C CP G++L      C
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 341  CPQGYKRLNSTH-CQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385
            CP G+    +   CQ+++ECA   G C +  C N PG + C CP G+
Sbjct: 2595 CPSGFDFDQALGGCQEVDECAGRRGPCSYS-CANTPGGFLCGCPQGY 2640


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  428 bits (1101), Expect = e-119
 Identities = 312/1045 (29%), Positives = 430/1045 (41%), Gaps = 205/1045 (19%)

Query: 292  NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST 351
            +P+PG  + + CC ++G AWG ++C +CP        KPG    E    CP+G    N  
Sbjct: 1014 HPVPGKFRMDACCCAVGAAWG-TECEECP--------KPGTKEYETL--CPRGAGFANRG 1062

Query: 352  HC-------QDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEE 401
                     +DINEC A PG+C +G C N  GS++C C  G +L      C  I +    
Sbjct: 1063 DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS 1122

Query: 402  KSLCFRLV------SPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT---DGTAAFK 452
              LC   +      S E +C     +       C  + +     C+R P     GT    
Sbjct: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDE-----CERNPLLCRGGTCVNT 1177

Query: 453  E---ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509
            E    C    G+ +  S +      E   S  L  +G           S  P  + T + 
Sbjct: 1178 EGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDR 1237

Query: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            +G T    + E   +     T  T     Y    S             +P  RS  +I  
Sbjct: 1238 QGCTD---IDECMIMNGGCDTQCTNSEGSYECSCSEGYAL--------MPDGRSCADI-- 1284

Query: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
                  DEC  N +IC  G+C   P +Y C C  G+ +    + C+DVNEC+        
Sbjct: 1285 ------DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688
            G C NT GS+ CHC  GY +  G  G  C D++EC    H C     C+N PG +KC+C 
Sbjct: 1339 GECENTKGSFICHCQLGYSVKKGTTG--CTDVDECEIGAHNCDMHASCLNIPGSFKCSCR 1396

Query: 689  PGYRLKASRPPVCEDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746
             G+     +   C D+DEC + +  C  + +C N PGS++C AC  G+   G   C DV+
Sbjct: 1397 EGWIGNGIK---CIDLDECSNGTHQCSINAQCVNTPGSYRC-ACSEGFTGDGF-TCSDVD 1451

Query: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805
            ECAE  + C  G C N+PG++RC C  G+ PA D RSC D+DEC   ++C  G C+N PG
Sbjct: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG 1511

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
             F C C  GY L R   +C DIDEC  P  C+ G C+NT G Y C CP   +L       
Sbjct: 1512 MFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQL------- 1564

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923
                         P G                        GC +    +    CYL F  
Sbjct: 1565 ------------NPTGV-----------------------GCVD----NRVGNCYLKFGP 1585

Query: 924  --DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981
              D ++ C++ +   V++  CCCSLG  WG+ CE   CP  +S E+++LCP G+G+  + 
Sbjct: 1586 RGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE--TCPPVNSTEYYTLCPGGEGFRPNP 1643

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL 1041
              +        DIDEC      +C+ G C+NT   ++C C QG+Y   +   C D+DEC 
Sbjct: 1644 ITI-----ILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECF 1697

Query: 1042 DESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNL 1100
                 C  G C NT G Y C C               PE M V+   +    R   C   
Sbjct: 1698 AHPGVCGPGTCYNTLGNYTCIC--------------PPEYMQVNGGHNCMDMRKSFCYRS 1743

Query: 1101 PGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFD 1160
                 CE              +LP +  +R                              
Sbjct: 1744 YNGTTCE-------------NELPFNVTKRM----------------------------- 1761

Query: 1161 DCCC--RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1218
             CCC    G+ W   C PCP  G         +     +D                  D 
Sbjct: 1762 -CCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDI-----------HTGKAVDI 1809

Query: 1219 DECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1273
            DEC+     C +G C+ + G   CECP GF  +     C DIDEC   N   L  ++  C
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS--NGDNLCQRNADC 1867

Query: 1274 VNTSGSFRCVCKAGFARSRPHGACV 1298
            +N+ GS+RC C AGF  S P+GACV
Sbjct: 1868 INSPGSYRCECAAGFKLS-PNGACV 1891



 Score =  407 bits (1046), Expect = e-113
 Identities = 239/742 (32%), Positives = 342/742 (46%), Gaps = 90/742 (12%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC+    +C +G+C      + C CN G+    + R C D++EC   P   G GIC+
Sbjct: 1073 DINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICV 1132

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693
            NT GS+ C C  GY        ++C+D++EC +  L   GG C+N  G ++C+C  G+ L
Sbjct: 1133 NTPGSFECECFEGYESGFMMM-KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1191

Query: 694  KASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEG 751
              SR   C DI+EC    + C +GKC N  G+++C +C PGY++      C D++EC   
Sbjct: 1192 SPSRED-CVDINECSLSDNLCRNGKCVNMIGTYQC-SCNPGYQATPDRQGCTDIDECMIM 1249

Query: 752  SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDNGICSNTPGSFQCQ 810
            +      C N  GS+ C+C++GYA  PDGRSC D+DECE   D+CD G C+N PG ++C 
Sbjct: 1250 NGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCL 1309

Query: 811  CLSGYHLSRDRSHCEDIDECDFPA-ACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDID 868
            C  G+  S D   C D++ECD  +  C+ G+C NT GS+ C C  G+ +  G   C D+D
Sbjct: 1310 CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVD 1369

Query: 869  ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            EC      C  H +C N+ GS+ C C EG+     +  C +++      EC         
Sbjct: 1370 ECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLD------EC--------- 1412

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988
                  +N T Q   CS+ A     C      V +   +   C +G  +T D    +   
Sbjct: 1413 ------SNGTHQ---CSINA----QC------VNTPGSYRCACSEG--FTGDGFTCS--- 1448

Query: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048
                D+DEC      +C+ G+C+N    Y C C+ GF    +   C D+DEC  ++ C  
Sbjct: 1449 ----DVDECAE-NINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVF 1503

Query: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCEC 1108
            G C N  G + C C    E       C      D+DEC DP  C  G CVN PG Y C C
Sbjct: 1504 GTCNNLPGMFHCICDDGYELDRTGGNC-----TDIDECADPINCVNGLCVNTPGRYECNC 1558

Query: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCW---SQRGEDGMCAGPLAGPALTFDDCCCR 1165
             P +   P+G  C            R   C+     RG+  +      G  ++   CCC 
Sbjct: 1559 PPDFQLNPTGVGC---------VDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCS 1609

Query: 1166 QGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--- 1222
             G+ WG  C  CPP             S  ++   P   G  P       ED DEC+   
Sbjct: 1610 LGKAWGNPCETCPP-----------VNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658

Query: 1223 --CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280
              C  G C+   G   CECP G+ L      C DIDEC      G +C    C NT G++
Sbjct: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC--FAHPG-VCGPGTCYNTLGNY 1715

Query: 1281 RCVCKAGFARSRPHGACVPQRR 1302
             C+C   + +      C+  R+
Sbjct: 1716 TCICPPEYMQVNGGHNCMDMRK 1737



 Score =  367 bits (942), Expect = e-101
 Identities = 259/820 (31%), Positives = 353/820 (43%), Gaps = 134/820 (16%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGP---- 627
            + +EC LN NIC  GEC      + CHC  GY        C DV+ECE  A  C      
Sbjct: 1325 DVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASC 1384

Query: 628  ----------------GRGI--------------------CMNTGGSYNCHCNRGYRLHV 651
                            G GI                    C+NT GSY C C+ G+    
Sbjct: 1385 LNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--- 1441

Query: 652  GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS 711
               G +C D++ECA+     + G C+N PG Y+C C  G+   AS    C+DIDEC   +
Sbjct: 1442 -GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT-PASDSRSCQDIDECSFQN 1499

Query: 712  SCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC 770
             C  G C N PG F CI C  GY   + GG C D++ECA+   C  G C N PG + C C
Sbjct: 1500 ICVFGTCNNLPGMFHCI-CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNC 1558

Query: 771  AQGYAPAPDGRSCLD--VDEC--EAGDVCDNGICSNTP-----GSFQCQCLSGYHLSRDR 821
               +   P G  C+D  V  C  + G   D  +  NT          C C  G       
Sbjct: 1559 PPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPC 1618

Query: 822  SHC---------------------------EDIDEC-DFPAACIGGDCINTNGSYRCLCP 853
              C                           EDIDEC + P  C GG+CINT GS++C CP
Sbjct: 1619 ETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECP 1678

Query: 854  QGHRLVGG-RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
            QG+ L    R C+DIDEC   P +C P G C N  G+Y C+C   +      H C ++  
Sbjct: 1679 QGYYLSEDTRICEDIDECFAHPGVCGP-GTCYNTLGNYTCICPPEYMQVNGGHNCMDMR- 1736

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCS--LGAGWGDHCEIYPCPVYSSAEFHSL 970
               K  CY +++ T  C++ L  NVT++ CCC+  +G  W   CE  PCP   +A+F ++
Sbjct: 1737 ---KSFCYRSYNGTT-CENELPFNVTKRMCCCTYNVGKAWNKPCE--PCPTPGTADFKTI 1790

Query: 971  CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN 1030
            C +  G+T D   ++ G     DIDEC      IC  G C+N    + C C  GF Y+  
Sbjct: 1791 CGNIPGFTFD---IHTGKAV--DIDECKEIPG-ICANGVCINQIGSFRCECPTGFSYNDL 1844

Query: 1031 LLECVDVDECLDESNC--RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD 1088
            LL C D+DEC +  N   RN  C N+ G YRC C    + SP    C     +D +EC +
Sbjct: 1845 LLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSP-NGAC-----VDRNECLE 1898

Query: 1089 -PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
             P  C  G CV+L GSY+C C   +        C +     ER P     C +  G    
Sbjct: 1899 IPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMC-MDVDECERHPCGNGTCKNTVGSYNC 1957

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKP 1207
               P  G  LT ++ C           + C      +   + +   N  ++ +P      
Sbjct: 1958 LCYP--GFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTP------ 2009

Query: 1208 PRDEDSSEEDSDECRCVSGRCVP-----RPGGAVCECPGGFQLDASRARCVDIDECRELN 1262
               +  +  D++EC  + G C P       G   C CP G+++ +    C+DI+EC E  
Sbjct: 2010 ---DGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINECDEDP 2064

Query: 1263 QRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1302
                +C    C NT G F+C+C  GF  S     C   R+
Sbjct: 2065 N---ICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQ 2101



 Score =  345 bits (886), Expect = 1e-94
 Identities = 239/765 (31%), Positives = 332/765 (43%), Gaps = 114/765 (14%)

Query: 592  PGPPDYSCHCN--PGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRL 649
            PG  D+   C   PG+         VD++EC+  P     G+C+N  GS+ C C  G+  
Sbjct: 1782 PGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSY 1841

Query: 650  HVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
            +       C D++EC+   +LC     CIN PG Y+C C  G++L  +    C D +EC 
Sbjct: 1842 NDLL--LVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG--ACVDRNECL 1897

Query: 709  D-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSF 766
            + P+ C  G C +  GS++CI C  G++ SQ    C DV+EC E  PC  G C+N  GS+
Sbjct: 1898 EIPNVCSHGLCVDLQGSYQCI-CHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSY 1955

Query: 767  RCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC 824
             C C  G+        CLD+DEC +  G VC NG C N  GSF+C C  GY L+ D  +C
Sbjct: 1956 NCLCYPGFE-LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC 2014

Query: 825  EDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGAC 883
             D +EC   P +C  G C N  GS+RC+CP G+  V    C DI+EC +DP++CL  G+C
Sbjct: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE-VKSENCIDINECDEDPNICL-FGSC 2072

Query: 884  KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECC 943
             N  G + C+C  GF  + +   C +  Q      C+ NF++   C    A N T+ +CC
Sbjct: 2073 TNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF----CFTNFENGK-CSVPKAFNTTKAKCC 2127

Query: 944  CSL--GAGWGDHCEIYP----------CP---------------VYSSAEFHSLCPDGKG 976
            CS   G GWGD CE+ P          CP               V    E   +C +G+ 
Sbjct: 2128 CSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQC 2187

Query: 977  YTQDNNI---------VNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY 1027
               D +          ++Y      D DEC +     C  G C N    +EC C +GF  
Sbjct: 2188 INTDGSFRCECPMGYNLDYTGVRCVDTDECSI--GNPCGNGTCTNVIGSFECNCNEGFE- 2244

Query: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087
             G ++ C D++EC          C NT G Y C C         Q+ C      D+DEC 
Sbjct: 2245 PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC-----KDLDECA 2299

Query: 1088 D---PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE 1144
            +       R   C NL G++ C C P     P G  C + E+     P    +C     E
Sbjct: 2300 EGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKP---GIC-----E 2350

Query: 1145 DGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL 1204
            +G C   +         C C +G    +    C     G               +S  L+
Sbjct: 2351 NGRCVNIIGSYR-----CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLV 2405

Query: 1205 GKPPRDEDSSEEDSDECRCVSGR-------CVPRPGGA----VCECPGGFQLDASRARCV 1253
             K             EC C  GR         P PG A    +C    G+  D       
Sbjct: 2406 TK------------SECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR----- 2448

Query: 1254 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
            DIDEC+ +     LC + +C+NT GSFRC CK G+       +C+
Sbjct: 2449 DIDECKVMPN---LCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490



 Score =  341 bits (874), Expect = 3e-93
 Identities = 210/602 (34%), Positives = 284/602 (47%), Gaps = 76/602 (12%)

Query: 702  EDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760
            + ID C+  ++ C +G+C     S++C  C  GY+    G C DV+EC   +PC+ G C 
Sbjct: 493  QTIDICKHHANLCLNGRCIPTVSSYRC-ECNMGYKQDANGDCIDVDECTS-NPCTNGDCV 550

Query: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819
            N PGS+ C C  G+   P  ++C+D+DEC + G +C NG C NT GSFQC C +G+ L+ 
Sbjct: 551  NTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610

Query: 820  DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCL 878
            D  +C D DEC     C+ G CIN +GS++C+C  G  L   GR C D+DEC Q P +C+
Sbjct: 611  DGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICM 669

Query: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVT 938
             +G C N +GS+ C C  G     D   C +    H +  CY      V C       VT
Sbjct: 670  -NGHCINSEGSFRCDCPPGLAVGMDGRVCVDT---HMRSTCYGGIKKGV-CVRPFPGAVT 724

Query: 939  QQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
            + ECCC+    G+G+ C+  PCP  +SAEFH LC  G G T D           RDI+EC
Sbjct: 725  KSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITVDG----------RDINEC 772

Query: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL-DESNCRNGVCENTRG 1056
             L   +IC  G C N +  Y C C  G+  D +   C+D+DECL +   C NG+C NT G
Sbjct: 773  AL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 831

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGP 1116
             Y C C P   +      C      D++EC+    C  G C N  GS+ CEC P      
Sbjct: 832  SYSCTCPPGYVFRTETETC-----EDINECESNP-CVNGACRNNLGSFNCECSPGSKLSS 885

Query: 1117 SGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP 1176
            +G  C             +  CW    +D  C   + G  L   +CC   G  WG+ C  
Sbjct: 886  TGLIC---------IDSLKGTCWLNI-QDSRCEVNINGATLK-SECCATLGAAWGSPCER 934

Query: 1177 CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPR 1231
            C    A   CP   +                 R +  + ED +EC      C +GRCV  
Sbjct: 935  CELDTA---CPRGLA-----------------RIKGVTCEDVNECEVFPGVCPNGRCVNS 974

Query: 1232 PGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN-TSGSFR---CVCKAG 1287
             G   CECP G  LD +   C+DI     + Q  L    + C++   G FR   C C  G
Sbjct: 975  KGSFHCECPEGLTLDGTGRVCLDI----RMEQCYLKWDEDECIHPVPGKFRMDACCCAVG 1030

Query: 1288 FA 1289
             A
Sbjct: 1031 AA 1032



 Score =  337 bits (863), Expect = 6e-92
 Identities = 234/773 (30%), Positives = 329/773 (42%), Gaps = 102/773 (13%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            +T+EC      C  G C      + C C PGY    ++  C+D+NEC+ +P     G C 
Sbjct: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE-----------CAKPHLCGDGGF---CINF 679
            NT G + C C  G+ L     GR C D  +           C+ P           C   
Sbjct: 2074 NTPGGFQCLCPPGFVL--SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131

Query: 680  PGH----------------YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722
            PG                 ++  C  G+    S     ED++EC + P  C +G+C N  
Sbjct: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191

Query: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781
            GSF+C  C  GY     G  C D +EC+ G+PC  G C N+ GSF C C +G+ P P   
Sbjct: 2192 GSFRC-ECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM-M 2249

Query: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838
            +C D++EC    +     C NT GS++C C  GY L  D+  C+D+DEC          G
Sbjct: 2250 NCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRG 2309

Query: 839  GDCINTNGSYRCLCPQGH-RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
              C N  G++ C+CP G  R   G  C D +EC   P +C  +G C N+ GSY C C+EG
Sbjct: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368

Query: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN-VTQQECCCSLGAGWGDHCEI 956
            F  +     C +  Q      C+     T+   +  + N VT+ ECCC  G GWG  CE+
Sbjct: 2369 FQSSSSGTECLDNRQGL----CFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424

Query: 957  YPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPG 1016
              CP+  +A++  +CP G GYT D           RDIDEC +  + +C  G+C+NT   
Sbjct: 2425 --CPLPGTAQYKKICPHGPGYTTDG----------RDIDECKVMPN-LCTNGQCINTMGS 2471

Query: 1017 YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL 1076
            + C+CK G+  D +   C+D+DEC       N +C+NT G Y+C+C          + C 
Sbjct: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC- 2530

Query: 1077 SPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRD 1136
                 D+DECQ         CVN  G + C+C P +             +    A    +
Sbjct: 2531 ----KDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF-------------TQHHTACIDNN 2573

Query: 1137 VCWSQR---GEDGMCAGPLAGPALTFDDCCCRQG---RGWGAQCRPCPPRGAGSHCPTS- 1189
             C SQ    G  G+C       +     C C++G      G  C           C    
Sbjct: 2574 ECGSQPSLCGAKGICQNTPGSFS-----CECQRGFSLDATGLNCEDVDECDGNHRCQHGC 2628

Query: 1190 QSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQL 1245
            Q+    +    P   G     + +   D +EC     C S  C    G   C CP GF  
Sbjct: 2629 QNILGGYRCGCPQ--GYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSF 2686

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
            D   + C D++EC         C +  C NT G + C C  G+ R    G CV
Sbjct: 2687 DQFSSACHDVNECSSSKNP---C-NYGCSNTEGGYLCGCPPGYYRV-GQGHCV 2734



 Score =  317 bits (812), Expect = 5e-86
 Identities = 257/874 (29%), Positives = 352/874 (40%), Gaps = 222/874 (25%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC    N+C HG CV     Y C C+ G+++      C+DV+ECE  PCG   G C 
Sbjct: 1892 DRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCG--NGTCK 1949

Query: 634  NTGGSYNCHCNRGYRL---------------------------HVGA------------- 653
            NT GSYNC C  G+ L                            +G+             
Sbjct: 1950 NTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTP 2009

Query: 654  GGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPS 711
             G++C+D NEC A P  C  G  C N  G ++C C PGY +K+     C DI+EC  DP+
Sbjct: 2010 DGKNCIDTNECVALPGSCSPGT-CQNLEGSFRCICPPGYEVKSEN---CIDINECDEDPN 2065

Query: 712  SCPDGKCENKPGSFKCIACQPGY-RSQGGGACRDVNECA-----EGSPCS---------- 755
             C  G C N PG F+C+ C PG+  S  G  C D  +       E   CS          
Sbjct: 2066 ICLFGSCTNTPGGFQCL-CPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKA 2124

Query: 756  ---------PGW---CENLPG----SFRCTCAQGYAPAP---DGRSCLDVDEC-EAGDVC 795
                      GW   CE  P     +F+  C  G+   P   D R   DV+EC E+  +C
Sbjct: 2125 KCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRE--DVNECLESPGIC 2182

Query: 796  DNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQG 855
             NG C NT GSF+C+C  GY+L      C D DEC     C  G C N  GS+ C C +G
Sbjct: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEG 2242

Query: 856  HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
                    C+DI+EC+Q+P LC     C N  GSY C C  G+   +DQ  C++++    
Sbjct: 2243 FEPGPMMNCEDINECAQNPLLCA--FRCMNTFGSYECTCPIGYALREDQKMCKDLD---- 2296

Query: 916  KKECYLNFDDT----VFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLC 971
              EC     D     + C +++ T +    C C  G                     +  
Sbjct: 2297 --ECAEGLHDCESRGMMCKNLIGTFM----CICPPGM--------------------ARR 2330

Query: 972  PDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNL 1031
            PDG+G   +N              EC      IC+ G+CVN    Y C C +GF    + 
Sbjct: 2331 PDGEGCVDEN--------------ECRT-KPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375

Query: 1032 LECVDVDE-----------CLDESNCRNGV------CENTRG-GYRCACTPPAEYSPAQR 1073
             EC+D  +           C   S+ RN V      C+  RG G++C   P    +  ++
Sbjct: 2376 TECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKK 2435

Query: 1074 QC-----LSPEEMDVDECQ-DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDC----QL 1123
             C      + +  D+DEC+  P  C  G+C+N  GS+RC C+  +    SG  C    + 
Sbjct: 2436 ICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495

Query: 1124 PESPAE-----RAPERRDVCWSQRG----EDG------------------MCAGPLAG-- 1154
             +SP       +  E    C   RG    EDG                  +C   L G  
Sbjct: 2496 SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFT 2555

Query: 1155 ----PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTS---QSESNSFWDTSPLLLGKP 1207
                P  T     C      G+Q   C  +G   + P S   + +     D + L     
Sbjct: 2556 CKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGL----- 2610

Query: 1208 PRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1263
                  + ED DEC    RC  G C    GG  C CP G+       +CVD +EC   N 
Sbjct: 2611 ------NCEDVDECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPN- 2662

Query: 1264 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
                C S  C NT GS++C C +GF+  +   AC
Sbjct: 2663 ---ACGSASCYNTLGSYKCACPSGFSFDQFSSAC 2693



 Score =  290 bits (743), Expect = 5e-78
 Identities = 237/808 (29%), Positives = 326/808 (40%), Gaps = 153/808 (18%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631
            + DEC+    +C  G C+     + C C  GY      R C D++EC A P  CGPG   
Sbjct: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-- 1707

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--CAKPHLCGDGGFCIN-FPGHY-KCNC 687
            C NT G+Y C C   Y + V  GG +C+D+ +  C + +   +G  C N  P +  K  C
Sbjct: 1708 CYNTLGNYTCICPPEY-MQVN-GGHNCMDMRKSFCYRSY---NGTTCENELPFNVTKRMC 1762

Query: 688  YPGYRLKASRPPVCE------------------------------DIDECRD-PSSCPDG 716
               Y +  +    CE                              DIDEC++ P  C +G
Sbjct: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANG 1822

Query: 717  KCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQG 773
             C N+ GSF+C  C  G+        C D++EC+ G         C N PGS+RC CA G
Sbjct: 1823 VCINQIGSFRC-ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881

Query: 774  YAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832
            +  +P+G +C+D +EC E  +VC +G+C +  GS+QC C +G+  S+D++ C D+DEC+ 
Sbjct: 1882 FKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE- 1939

Query: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
               C  G C NT GSY CLC  G  L     C DIDECS        +G C N  GS+ C
Sbjct: 1940 RHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKC 1999

Query: 893  VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952
            +C+EG+  T D   C                             +   EC    G+    
Sbjct: 2000 LCNEGYELTPDGKNC-----------------------------IDTNECVALPGSCSPG 2030

Query: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVN 1012
             C+           F  +CP G     +N I         DI+EC      IC  G C N
Sbjct: 2031 TCQNL------EGSFRCICPPGYEVKSENCI---------DINECDE-DPNICLFGSCTN 2074

Query: 1013 TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCE-----NTRGGYRCACTPPAE 1067
            T  G++C C  GF    N   C D  +    +N  NG C      NT     C    P E
Sbjct: 2075 TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGE 2134

Query: 1068 ----------------------YSPAQRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSY 1104
                                  Y       L     DV+EC + P  C  G+C+N  GS+
Sbjct: 2135 GWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSF 2194

Query: 1105 RCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG--EDGMCAGPLAGPALTFDDC 1162
            RCEC   +    +G  C   +  +   P     C +  G  E     G   GP +  +D 
Sbjct: 2195 RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDI 2254

Query: 1163 C-CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
              C Q            P      C    +   S+  T P+  G   R++    +D DEC
Sbjct: 2255 NECAQN-----------PLLCAFRC---MNTFGSYECTCPI--GYALREDQKMCKDLDEC 2298

Query: 1222 R-----CVSG--RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCV 1274
                  C S    C    G  +C CP G         CVD +ECR    +  +C++ RCV
Sbjct: 2299 AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRT---KPGICENGRCV 2355

Query: 1275 NTSGSFRCVCKAGFARSRPHGACVPQRR 1302
            N  GS+RC C  GF  S     C+  R+
Sbjct: 2356 NIIGSYRCECNEGFQSSSSGTECLDNRQ 2383



 Score =  278 bits (710), Expect = 3e-74
 Identities = 234/825 (28%), Positives = 320/825 (38%), Gaps = 163/825 (19%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC L+ +IC +G C      Y C+CN GY      R C+D++EC         G+C 
Sbjct: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCR 827

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693
            NT GSY+C C  GY         +C D+NEC + + C +G  C N  G + C C PG +L
Sbjct: 828  NTPGSYSCTCPPGYVFRTET--ETCEDINEC-ESNPCVNGA-CRNNLGSFNCECSPGSKL 883

Query: 694  KASRPPVCEDIDECRDPSSCPDGKCE-NKPGSF------------------KC---IACQ 731
             +S   +C D  +     +  D +CE N  G+                   +C    AC 
Sbjct: 884  -SSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACP 942

Query: 732  PGYRSQGGGACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789
             G     G  C DVNEC E  P  C  G C N  GSF C C +G      GR CLD+   
Sbjct: 943  RGLARIKGVTCEDVNEC-EVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001

Query: 790  EAGDVCDNGICSN-TPGSFQ---CQCLSGYHLSRDRSHC--------------------- 824
            +     D   C +  PG F+   C C  G     +   C                     
Sbjct: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061

Query: 825  ----------EDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQ 872
                      +DI+EC  FP  C  G C NT GS++C C  G  L +  R C DIDEC  
Sbjct: 1062 GDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRI 1121

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDS 931
             P LC   G C N  GS+ C C EG+ +       C +++      EC  N    + C  
Sbjct: 1122 SPDLC-GSGICVNTPGSFECECFEGYESGFMMMKNCMDID------ECERN---PLLCRG 1171

Query: 932  VLATNVTQQ-ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990
                N     +C C LG                    H L P  +               
Sbjct: 1172 GTCVNTEGSFQCDCPLG--------------------HELSPSREDCV------------ 1199

Query: 991  HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050
              DI+EC L    +C+ GKCVN    Y+C C  G+    +   C D+DEC+  +   +  
Sbjct: 1200 --DINECSL-SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ 1256

Query: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ-DPAACRPGRCVNLPGSYRCECR 1109
            C N+ G Y C+C+      P  R C      D+DEC+ +P  C  G+C N+PG YRC C 
Sbjct: 1257 CTNSEGSYECSCSEGYALMPDGRSC-----ADIDECENNPDICDGGQCTNIPGEYRCLCY 1311

Query: 1110 PPWVPGPSGR-----------------------------DCQLPESPAERAPERRDVCWS 1140
              ++     +                              CQL  S  +      DV   
Sbjct: 1312 DGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDEC 1371

Query: 1141 QRGEDG--MCAGPLAGPALTFDDCCCRQG-RGWGAQCRPCPPRGAGSHCPTSQSESNSFW 1197
            + G     M A  L  P      C CR+G  G G +C        G+H  +  ++  +  
Sbjct: 1372 EIGAHNCDMHASCLNIPGSF--KCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTP 1429

Query: 1198 DTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARC 1252
             +      +    +  +  D DEC      C +G+C+  PG   CEC  GF   +    C
Sbjct: 1430 GSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSC 1489

Query: 1253 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
             DIDEC   N    +C    C N  G F C+C  G+   R  G C
Sbjct: 1490 QDIDECSFQN----ICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530



 Score =  251 bits (640), Expect = 4e-66
 Identities = 189/608 (31%), Positives = 237/608 (38%), Gaps = 147/608 (24%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631
            +TDEC +  N CG+G C      + C+CN G+   P    C D+NEC   P  C      
Sbjct: 2213 DTDECSIG-NPCGNGTCTNVIGSFECNCNEGFEPGPMMN-CEDINECAQNPLLCAFR--- 2267

Query: 632  CMNTGGSYNCHCNRGYRLH-----------------------------VGA--------- 653
            CMNT GSY C C  GY L                              +G          
Sbjct: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGM 2327

Query: 654  ----GGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPP--------- 699
                 G  CVD NEC  KP +C + G C+N  G Y+C C  G++  +S            
Sbjct: 2328 ARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386

Query: 700  -------VCEDIDECRD----PSSCPDG------KCENKP----GSFKCIACQ-PGYRSQ 737
                   +C+     R+       C DG      +CE  P      +K I    PGY + 
Sbjct: 2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTD 2446

Query: 738  GGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
            G    RD++EC    + C+ G C N  GSFRC C  GY     G SC+D+DEC       
Sbjct: 2447 G----RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC 2502

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGH 856
            N IC NT GS+QC C  GY L  D   C+D+DEC          C+NT G + C CP G 
Sbjct: 2503 NYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF 2562

Query: 857  RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHK 916
                   C D +EC   PSLC   G C+N  GS+ C C  GF+       CE+V++    
Sbjct: 2563 TQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGN 2621

Query: 917  KECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKG 976
              C                   Q  C   LG         Y C           CP  +G
Sbjct: 2622 HRC-------------------QHGCQNILGG--------YRCG----------CP--QG 2642

Query: 977  YTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVD 1036
            Y Q     +Y      D +EC       C    C NT   Y+C C  GF +D     C D
Sbjct: 2643 YIQ-----HYQWNQCVDENECS--NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHD 2695

Query: 1037 VDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS------------PEEMDVD 1084
            V+EC    N  N  C NT GGY C C PP  Y   Q  C+S              E+D +
Sbjct: 2696 VNECSSSKNPCNYGCSNTEGGYLCGC-PPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEE 2754

Query: 1085 ECQDPAAC 1092
                P AC
Sbjct: 2755 NALSPEAC 2762



 Score =  242 bits (617), Expect = 2e-63
 Identities = 234/912 (25%), Positives = 327/912 (35%), Gaps = 251/912 (27%)

Query: 532  TTTPARPYPELISRPSPPTMR-----------WFLPDLPPSRSAVEIAPTQVTETDECRL 580
            T    +P P    RP PP  +           +  P+     +AV     +  + D  R 
Sbjct: 26   TAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLR- 84

Query: 581  NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640
              N+CG          +  +C PG+++ P    C+ V  C    CG G   C        
Sbjct: 85   GPNVCGSR--------FHSYCCPGWKTLPGGNQCI-VPICR-NSCGDG--FCSRPN---M 129

Query: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
            C C+ G ++    G +S   + +C+    C +GG C +      C C  GY       PV
Sbjct: 130  CTCSSG-QISSTCGSKS---IQQCSVR--CMNGGTCADD----HCQCQKGYIGTYCGQPV 179

Query: 701  CEDIDE----CRDPSSCP------DGKCENKPGSFKCIACQPGYRSQG---GGACRDVNE 747
            CE+  +    C  P+ C         +CE    +  C         QG   G  C     
Sbjct: 180  CENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLC 239

Query: 748  CAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGS 806
            CA         CE  P   +  C +G+ P     +C DVDEC+A   +C  G C NT GS
Sbjct: 240  CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS 298

Query: 807  FQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGH-RLVGGRKC 864
            F+C+C +G+  S     CEDIDEC   P  C  G+C NT GSY C+CP+G+     G +C
Sbjct: 299  FECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358

Query: 865  QDIDECSQDPSLC---LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921
             D     Q   +C   L +G C                        +E+     K +C  
Sbjct: 359  ID-----QRTGMCFSGLVNGRC-----------------------AQELPGRMTKMQC-- 388

Query: 922  NFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD-------- 973
                                 CC  G  WG       CPV  S E+  LC D        
Sbjct: 389  ---------------------CCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIP 427

Query: 974  -----------GKGYTQDNNIVNYG--------IPA------------------------ 990
                       G G+    N   YG        IP                         
Sbjct: 428  GSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITG 487

Query: 991  ----HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
                ++ ID C    + +C  G+C+ T   Y C C  G+  D N  +C+DVDEC   + C
Sbjct: 488  LTILNQTIDICK-HHANLCLNGRCIPTVSSYRCECNMGYKQDAN-GDCIDVDEC-TSNPC 544

Query: 1047 RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE-------------------------- 1080
             NG C NT G Y C C    + +P ++ C+  +E                          
Sbjct: 545  TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNA 604

Query: 1081 -----------MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR------DCQL 1123
                       +D DEC     C  G C+N  GS++C C+P +V  P+GR      +CQ 
Sbjct: 605  GFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT 664

Query: 1124 P-----------------ESPAERA----------PERRDVCWSQRGEDGMCAGPLAGPA 1156
            P                 + P   A             R  C+    + G+C  P  G  
Sbjct: 665  PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGI-KKGVCVRPFPGAV 723

Query: 1157 LTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEE 1216
               + CC     G+G  C+PCP +            S  F       +G      D +E 
Sbjct: 724  TKSECCCANPDYGFGEPCQPCPAK-----------NSAEFHGLCSSGVGITVDGRDINEC 772

Query: 1217 DSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNT 1276
              D   C +G C    G   C C  G++ DAS   C+DIDEC  +N+  LLC +  C NT
Sbjct: 773  ALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL-VNR--LLCDNGLCRNT 829

Query: 1277 SGSFRCVCKAGF 1288
             GS+ C C  G+
Sbjct: 830  PGSYSCTCPPGY 841



 Score =  236 bits (602), Expect = 1e-61
 Identities = 174/591 (29%), Positives = 245/591 (41%), Gaps = 57/591 (9%)

Query: 295  PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP----------------VRGEVG 338
            PG+     C  + G+   + +C     L YTGV+                    V G   
Sbjct: 2179 PGICSNGQCINTDGSF--RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFE 2236

Query: 339  ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
             +C +G++     +C+DINECA   +     C+N  GSY C CP G++L   +  C  D 
Sbjct: 2237 CNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC-KDL 2295

Query: 399  PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE-ICPA 457
             E         S    C++ + T +    C C  G A     + C  +     K  IC  
Sbjct: 2296 DECAEGLHDCESRGMMCKNLIGTFM----CICPPGMARRPDGEGCVDENECRTKPGICEN 2351

Query: 458  GKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSP 517
            G+  +I+ S++    +G    S     +     Q L  +       +     R + T S 
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSS--GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSE 2409

Query: 518  VSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDE 577
               +      H            EL   P     +   P  P          T   + DE
Sbjct: 2410 CCCDGGRGWGHQC----------ELCPLPGTAQYKKICPHGPGYT-------TDGRDIDE 2452

Query: 578  CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
            C++  N+C +G+C+     + C C  GY +      C+D++EC   P  P   IC NT G
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP-KPCNYICKNTEG 2511

Query: 638  SYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
            SY C C RGY L     G++C DL+EC  K H C     C+N  G + C C PG+     
Sbjct: 2512 SYQCSCPRGYVLQ--EDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGF---TQ 2564

Query: 697  RPPVCEDIDEC-RDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP 753
                C D +EC   PS C   G C+N PGSF C  CQ G+     G  C DV+EC     
Sbjct: 2565 HHTACIDNNECGSQPSLCGAKGICQNTPGSFSC-ECQRGFSLDATGLNCEDVDECDGNHR 2623

Query: 754  CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
            C  G C+N+ G +RC C QGY        C+D +EC   + C +  C NT GS++C C S
Sbjct: 2624 CQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682

Query: 814  GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC 864
            G+   +  S C D++EC          C NT G Y C CP G+  VG   C
Sbjct: 2683 GFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHC 2733



 Score =  197 bits (500), Expect = 7e-50
 Identities = 217/803 (27%), Positives = 289/803 (35%), Gaps = 178/803 (22%)

Query: 582  QNICGHGECVPGPPDYSC-------HCNPGYRSHPQHRYCVDVNECEAEPCGP--GRGIC 632
            +N C +G    GP   +C        C   YR+ P     V+   C+ +  G    + +C
Sbjct: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQ-VNNQMCQGQLTGIVCTKTLC 239

Query: 633  MNTGGSYNCH-----------CNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFP 680
              T G    H           C RG+  ++  G  +C D++EC A P +C  GG CIN  
Sbjct: 240  CATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG--ACQDVDECQAIPGIC-QGGNCINTV 296

Query: 681  GHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGY-RSQG 738
            G ++C C  G++ ++     CEDIDEC   P  C  G+C N  GS+ C+ C  GY  S  
Sbjct: 297  GSFECRCPAGHK-QSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV-CPRGYVTSTD 354

Query: 739  GGACRD----------VN-ECAEGSP---------CSPGWC------------------- 759
            G  C D          VN  CA+  P         C PG C                   
Sbjct: 355  GSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYR 414

Query: 760  ---------ENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGS 806
                       +PGS       T   G+AP+ +G                NG      G+
Sbjct: 415  RLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGA 474

Query: 807  FQCQCLSGYHLSRDRSHCEDIDECDFPA-ACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
                   G  ++      + ID C   A  C+ G CI T  SYRC C  G++      C 
Sbjct: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCI 534

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDD 925
            D+DEC+ +P     +G C N  GSY C C  GF  T  +  C +++      EC  N   
Sbjct: 535  DVDECTSNP---CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDID------ECIQN--- 582

Query: 926  TVFCDSVLATNVTQQ-ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIV 984
             V C +    N     +C C+ G                      L  DGK         
Sbjct: 583  GVLCKNGRCVNTDGSFQCICNAG--------------------FELTTDGKNCV------ 616

Query: 985  NYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044
                    D DEC    + +C  G C+N    ++C CK GF    N   C DVDEC    
Sbjct: 617  --------DHDECTT--TNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPG 666

Query: 1045 NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVN-LPGS 1103
             C NG C N+ G +RC C P        R C+         C      + G CV   PG+
Sbjct: 667  ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRST--CY--GGIKKGVCVRPFPGA 722

Query: 1104 Y---RCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFD 1160
                 C C  P      G  CQ    PA+ + E   +C S             G  +T D
Sbjct: 723  VTKSECCCANP--DYGFGEPCQ--PCPAKNSAEFHGLCSS-------------GVGITVD 765

Query: 1161 DCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
                  GR    +C   P   A   C   +       ++     G  P     +  D DE
Sbjct: 766  ------GRDIN-ECALDPDICANGICENLRGSYRCNCNS-----GYEPDASGRNCIDIDE 813

Query: 1221 C-----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1275
            C      C +G C   PG   C CP G+        C DI+EC E N     C +  C N
Sbjct: 814  CLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESNP----CVNGACRN 868

Query: 1276 TSGSFRCVCKAGFARSRPHGACV 1298
              GSF C C  G   S     C+
Sbjct: 869  NLGSFNCECSPGSKLSSTGLICI 891



 Score =  158 bits (399), Expect = 4e-38
 Identities = 161/620 (25%), Positives = 224/620 (36%), Gaps = 117/620 (18%)

Query: 732  PGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECE 790
            P YR +G      V    +      P  C +    F   C  G+   P G  C+ V  C 
Sbjct: 61   PEYREEGAAVASRVRRRGQQDVLRGPNVCGS---RFHSYCCPGWKTLPGGNQCI-VPICR 116

Query: 791  AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNGSYR 849
              + C +G CS       C C SG   S   S  + I +C     C+ GG C + +    
Sbjct: 117  --NSCGDGFCSRPN---MCTCSSGQISSTCGS--KSIQQCS--VRCMNGGTCADDH---- 163

Query: 850  CLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909
            C C +G+  +G    Q + E       C   G C    G   C C  GFT  Q       
Sbjct: 164  CQCQKGY--IGTYCGQPVCENG-----CQNGGRCI---GPNRCACVYGFTGPQ------- 206

Query: 910  VEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHS 969
             E+ +    C+   ++ +    +     T+  CC ++G  WG  CE+  CP         
Sbjct: 207  CERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEM--CPAQPQ----- 259

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG 1029
              P  +G+     I N    A +D+DEC      IC+ G C+NT   +EC C  G     
Sbjct: 260  --PCRRGF-----IPNIRTGACQDVDECQAIPG-ICQGGNCINTVGSFECRCPAGHKQSE 311

Query: 1030 NLLECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD 1088
               +C D+DEC +    C  G C NT G Y C C      S    +C+   +     C  
Sbjct: 312  TTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCI---DQRTGMCF- 367

Query: 1089 PAACRPGRCV-NLPG---SYRCECRPP--WVPGPSGRDCQLPESPAERAPERRDVCWSQR 1142
             +    GRC   LPG     +C C P   W  G     C     P   + E R +C    
Sbjct: 368  -SGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEAC-----PVRGSEEYRRLCMDGL 421

Query: 1143 GEDGMCAGPLAGPALTFDDCCCRQGRG-----WGAQCRPCPPRGAGSHCPTSQSESNSFW 1197
               G+     + P  T  +     G G      G    P P  G     P          
Sbjct: 422  PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIP--GGNGFSPGVGGAGVGAG 479

Query: 1198 DTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP--------------------------- 1230
               P++ G    ++           C++GRC+P                           
Sbjct: 480  GQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDEC 539

Query: 1231 ------------RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1278
                         PG   C+C  GFQ   ++  C+DIDEC    Q G+LCK+ RCVNT G
Sbjct: 540  TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDEC---IQNGVLCKNGRCVNTDG 596

Query: 1279 SFRCVCKAGFARSRPHGACV 1298
            SF+C+C AGF  +     CV
Sbjct: 597  SFQCICNAGFELTTDGKNCV 616



 Score =  130 bits (328), Expect = 6e-30
 Identities = 60/167 (35%), Positives = 90/167 (53%), Gaps = 22/167 (13%)

Query: 296  GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQD 355
            G T + +CC ++G AWG S C +C                E+   CP+G  R+    C+D
Sbjct: 913  GATLKSECCATLGAAWG-SPCERC----------------ELDTACPRGLARIKGVTCED 955

Query: 356  INECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414
            +NEC + PGVC +G C+N+ GS+ C CP G +L  +   C+  + E+   C+ L   E +
Sbjct: 956  VNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ---CY-LKWDEDE 1011

Query: 415  CQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461
            C HP+  +     CCC+VG AWG  C+ CP  GT  ++ +CP G G+
Sbjct: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058



 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 38/188 (20%)

Query: 303 CCGSIGTAWGQSKCHKCPQLQYT------------------------GVQKPGPVRGEVG 338
           CC +IG AWG   C  CP                             G+ + G     VG
Sbjct: 239 CCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVG 297

Query: 339 A---DCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
           +    CP G+K+  +T  C+DI+EC++ PG+C  G+C N  GSY CVCP G+      ++
Sbjct: 298 SFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSR 357

Query: 394 CIADKPEEKSLCFR-LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAA 450
           CI    +   +CF  LV+   +C   L  R+T+  CCC  G+ WG     + CP  G+  
Sbjct: 358 CI---DQRTGMCFSGLVN--GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEE 412

Query: 451 FKEICPAG 458
           ++ +C  G
Sbjct: 413 YRRLCMDG 420



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 64/212 (30%), Positives = 84/212 (39%), Gaps = 42/212 (19%)

Query: 1095 GRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAG 1154
            GRC+   G  RC C    V G +G  C+           R   C++Q     MC G L G
Sbjct: 188  GRCI---GPNRCAC----VYGFTGPQCE--------RDYRTGPCFTQVNNQ-MCQGQLTG 231

Query: 1155 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1214
               T   CC   GR WG  C  CP +                    P   G  P     +
Sbjct: 232  IVCTKTLCCATIGRAWGHPCEMCPAQ------------------PQPCRRGFIPNIRTGA 273

Query: 1215 EEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK 1269
             +D DEC+     C  G C+   G   C CP G +   +  +C DIDEC  +     +C+
Sbjct: 274  CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPG---ICE 330

Query: 1270 SERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301
            +  C NT GS+ CVC  G+  S     C+ QR
Sbjct: 331  TGECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 13/138 (9%)

Query: 349 NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRL 408
           N  +C D++EC  PG+C +G C+N+ GS+RC CPPG ++G     C+      +S C+  
Sbjct: 652 NGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--DTHMRSTCYGG 709

Query: 409 VSPEHQCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSH 467
           +  +  C  P    +T+  CCC +    +G  CQ CP   +A F  +C +G G       
Sbjct: 710 IK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG------- 761

Query: 468 QTLTIQGESDFSLFLHPD 485
             +T+ G       L PD
Sbjct: 762 --ITVDGRDINECALDPD 777



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 48/160 (30%), Positives = 70/160 (43%), Gaps = 40/160 (25%)

Query: 341  CPQGYKRL-NSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
            C +GY+   +  +C D NEC A+PG C  G C N  GS+RC+CPPG+ +       I + 
Sbjct: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINEC 2060

Query: 399  PEEKSLC-----------FRLVSP-------------------------EHQCQHPLTTR 422
             E+ ++C           F+ + P                           +C  P    
Sbjct: 2061 DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFN 2120

Query: 423  LTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKG 460
             T+  CCCS   G+ WG  C+ CP D   AF+++CP G G
Sbjct: 2121 TTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 12/125 (9%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
           G     CP GY  R  +  C+DINEC     C +G C NN GS+ C C PG  L  +   
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLI 889

Query: 394 CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE 453
           CI      K  C+ L   + +C+  +     +  CC ++G AWG+ C+RC  D       
Sbjct: 890 CI---DSLKGTCW-LNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELD------T 939

Query: 454 ICPAG 458
            CP G
Sbjct: 940 ACPRG 944



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 61/237 (25%), Positives = 84/237 (35%), Gaps = 44/237 (18%)

Query: 1083 VDECQDPA-ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQ 1141
            +D C+  A  C  GRC+    SYRCEC   +    +G    + E  +   P     C + 
Sbjct: 495  IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN--PCTNGDCVNT 552

Query: 1142 RGE------DGMCAGPLAGPALTFDDCC-----CRQGRGWGAQCRPCPPRGAGSHCPTSQ 1190
             G        G    P     +  D+C      C+ GR        C        C  + 
Sbjct: 553  PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--------CVNTDGSFQCICNA 604

Query: 1191 SESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLD 1246
                          G     +  +  D DEC     C++G C+   G   C C  GF L 
Sbjct: 605  --------------GFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLA 650

Query: 1247 ASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303
             +   C D+DEC    Q   +C +  C+N+ GSFRC C  G A       CV    R
Sbjct: 651  PNGRYCTDVDEC----QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMR 703



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGE 336
            G+C ++T+    C  N    L  +E  C  I       +C   P L  +G+    P  G 
Sbjct: 1087 GKC-RNTIGSFKCRCNSGFALDMEERNCTDI------DECRISPDLCGSGICVNTP--GS 1137

Query: 337  VGADCPQGYKR--LNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
               +C +GY+   +   +C DI+EC   P +CR G C+N  GS++C CP GH L PSR  
Sbjct: 1138 FECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRED 1197

Query: 394  CI 395
            C+
Sbjct: 1198 CV 1199



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 25/151 (16%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPV 333
            G CF + L      ++    L  + +CC   G  WG  +C  CP     QY  +   GP 
Sbjct: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH-QCELCPLPGTAQYKKICPHGP- 2441

Query: 334  RGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
                      GY    +T  +DI+EC  MP +C +G C+N  GS+RC C  G++   S T
Sbjct: 2442 ----------GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487

Query: 393  QCI-----ADKPEEKSLCFRLVSPEHQCQHP 418
             CI     +  P+  +   +     +QC  P
Sbjct: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCSCP 2518



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 25/129 (19%)

Query: 287  QPCGSNPLPGLTKQEDCCGSI---------GTAWGQSKCHKCPQLQYTGVQKPGPVRGEV 337
            +PC   P PG    +  CG+I         G A    +C + P     G+   G    ++
Sbjct: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIP-----GICANGVCINQI 1828

Query: 338  GA---DCPQGYKRLNSTH-CQDINECAM-PGVC-RHGDCLNNPGSYRCVCPPGHSLGPS- 390
            G+   +CP G+   +    C+DI+EC+    +C R+ DC+N+PGSYRC C  G  L P+ 
Sbjct: 1829 GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG 1888

Query: 391  ----RTQCI 395
                R +C+
Sbjct: 1889 ACVDRNECL 1897



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 46/238 (19%)

Query: 333  VRGEVGADCPQGY-KRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            + G     CPQGY +      C D NEC+ P  C    C N  GSY+C CP G S     
Sbjct: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFS 2690

Query: 392  TQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + C      + + C    S ++ C +  +      LC              CP       
Sbjct: 2691 SAC-----HDVNEC---SSSKNPCNYGCSNTEGGYLC-------------GCPPGYYRVG 2729

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
            +  C +G G++     Q L++  E D       +    P+   E        +D+ ++R 
Sbjct: 2730 QGHCVSGMGFN---KGQYLSLDTEVD------EENALSPEACYECKINGYSKKDSRQKRS 2780

Query: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            +    P + E+   +S               +   SP  M++ L  L      +E+ P
Sbjct: 2781 IHEPDPTAVEQISLES---------------VDMDSPVNMKFNLSHLGSKEHILELRP 2823



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
           P       +C  GYK+  +  C D++EC     C +GDC+N PGSY C C  G    P++
Sbjct: 512 PTVSSYRCECNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTK 570

Query: 392 TQCI 395
             CI
Sbjct: 571 QACI 574



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 327  VQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385
            +  PG  R E    C  G+K   +  C D NEC  +P VC HG C++  GSY+C+C  G 
Sbjct: 1868 INSPGSYRCE----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923

Query: 386  SLGPSRTQCIADKPEEKSLC 405
                 +T C+     E+  C
Sbjct: 1924 KASQDQTMCMDVDECERHPC 1943



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 45/156 (28%), Positives = 66/156 (42%), Gaps = 28/156 (17%)

Query: 293 PLPG-LTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQGYKRL 348
           P PG +TK E CC +    +G+  C  CP     ++ G+   G     VG          
Sbjct: 718 PFPGAVTKSECCCANPDYGFGEP-CQPCPAKNSAEFHGLCSSG-----VGI--------- 762

Query: 349 NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
            +   +DINECA+ P +C +G C N  GSYRC C  G+    S   CI     ++ L  R
Sbjct: 763 -TVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI---DIDECLVNR 818

Query: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443
           L+     C++   +      C C  G  +    + C
Sbjct: 819 LLCDNGLCRNTPGS----YSCTCPPGYVFRTETETC 850



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            G     C  G++  ++  C DI+EC+     VCR+G C N  GS++C+C  G+ L P   
Sbjct: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012

Query: 393  QCI 395
             CI
Sbjct: 2013 NCI 2015



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 13/90 (14%)

Query: 359 CAMPGVCRHGDCLNNP---GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQC 415
           C  P VC +G C N     G  RC C  G + GP   QC  ++      CF  V+ +  C
Sbjct: 175 CGQP-VCENG-CQNGGRCIGPNRCACVYGFT-GP---QC--ERDYRTGPCFTQVNNQ-MC 225

Query: 416 QHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444
           Q  LT  + T+ LCC ++G+AWG  C+ CP
Sbjct: 226 QGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 335 GEVGADCPQGYKRLNSTH-CQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
           G     C  G++R  +   C DI+EC   GV C++G C+N  GS++C+C  G  L     
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613

Query: 393 QCI 395
            C+
Sbjct: 614 NCV 616



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 333  VRGEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            ++G     C  G+K   + T C D++EC     C +G C N  GSY C+C PG  L
Sbjct: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHP-CGNGTCKNTVGSYNCLCYPGFEL 1965



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 45/164 (27%), Positives = 61/164 (37%), Gaps = 30/164 (18%)

Query: 6   GAAGG-LAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKV 64
           G+ GG LAPE R  GAA               +  RV     G++    G  +   RF  
Sbjct: 53  GSEGGFLAPEYREEGAA---------------VASRVRR--RGQQDVLRGPNVCGSRFHS 95

Query: 65  VFAP----VICKRTCLKGQCRDSCQQG----SNMTLIGENGHSTDTLTGSGFRVVVCPLP 116
              P    +     C+   CR+SC  G     NM        S+   T     +  C + 
Sbjct: 96  YCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS---TCGSKSIQQCSVR 152

Query: 117 CMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160
           CMNGG C+  + C C   + G +C  P    G   GG   G +R
Sbjct: 153 CMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNR 195



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 19/75 (25%)

Query: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126
           C   C+ G  C D    CQ+G   T  G+                VC   C NGG+C   
Sbjct: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQP---------------VCENGCQNGGRCIGP 193

Query: 127 NQCLCPPDFTGRFCQ 141
           N+C C   FTG  C+
Sbjct: 194 NRCACVYGFTGPQCE 208


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  405 bits (1041), Expect = e-112
 Identities = 307/1054 (29%), Positives = 440/1054 (41%), Gaps = 181/1054 (17%)

Query: 293  PLPGLTKQEDCCGSIGTAWGQSKCHKCPQL---QYTGVQKPGPVRGEVGADCPQGYKRLN 349
            P+ G  + + CC S+G AWG  +C +CP     +Y  +   GP  G    +   G     
Sbjct: 970  PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGP--GFATKEITNG----- 1022

Query: 350  STHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLCF 406
                +DINEC M P +C HG C N  GS++C C  G +L      C  I +      LC 
Sbjct: 1023 KPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCG 1082

Query: 407  R---LVSP---EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCP----------TDGTAA 450
            R   + +P   E +C     +       C  + +     CQR P          T+G+  
Sbjct: 1083 RGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDE-----CQRDPLLCRGGVCHNTEGS-- 1135

Query: 451  FKEICPAGKGYHILTSHQTLTIQ-GESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509
            ++  CP G   H L+ + +  I   E + S  L P+G      + +      P   +  +
Sbjct: 1136 YRCECPPG---HQLSPNISACIDINECELSAHLCPNGRCV-NLIGKYQCACNPGYHSTPD 1191

Query: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            R    D    +E S+         T +    E   +P    M       P  RS  +I  
Sbjct: 1192 RLFCVDI---DECSIMNGGCETFCTNSEGSYECSCQPGFALM-------PDQRSCTDI-- 1239

Query: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
                  DEC  N NIC  G+C   P +Y C C  G+ +    + CVDVNEC+  P     
Sbjct: 1240 ------DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLS 1293

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688
            G C NT GS+ CHC+ GY    G  G  C D+NEC    H CG    C N  G +KC+C 
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTG--CTDINECEIGAHNCGKHAVCTNTAGSFKCSCS 1351

Query: 689  PGYRLKASRPPVCEDIDECRDPSSC--PDGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746
            PG+     +   C D+DEC + +        C+N  GS++C+ C+ GY   G   C D++
Sbjct: 1352 PGWIGDGIK---CTDLDECSNGTHMCSQHADCKNTMGSYRCL-CKEGYTGDGF-TCTDLD 1406

Query: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805
            EC+E  + C  G C N PG +RC C  G+ P+ DG++C D+DEC   ++C  G C N PG
Sbjct: 1407 ECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPG 1466

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
             F+C+C  GY L R   +C D++EC  P  CI G+C+NT GSY C CP    L       
Sbjct: 1467 LFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL------- 1519

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923
                                              PT  + GC +    +    CYL+   
Sbjct: 1520 ---------------------------------NPT--RVGCVDTRSGN----CYLDIRP 1540

Query: 924  ---DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD 980
               +    C + +   V++  CCCSLG  WG  CE+  CP  +++E+  LCP G+G+  +
Sbjct: 1541 RGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEM--CPAVNTSEYKILCPGGEGFRPN 1598

Query: 981  NNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1040
               V        DIDEC      +C+ GKC+NT   ++C C  G+Y + +   C DV+EC
Sbjct: 1599 PITV-----ILEDIDECQELPG-LCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC 1652

Query: 1041 LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-----QDPAACRPG 1095
                 C  G C NT G Y C C P          C+   +M    C      D   C   
Sbjct: 1653 ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCM---DMRRSLCYRNYYADNQTCDGE 1709

Query: 1096 RCVNLPGSYRC---ECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPL 1152
               N+     C        W      + C+  + P     E   +C SQR   G      
Sbjct: 1710 LLFNMTKKMCCCSYNIGRAW-----NKPCE--QCPIPSTDEFATLCGSQR--PGFVIDIY 1760

Query: 1153 AGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS---HCPTSQSESNSFWDTSPLLLGKPPR 1209
             G  +  D+C    G      C        GS    CP        F+    LL+     
Sbjct: 1761 TGLPVDIDECREIPGVCENGVC----INMVGSFRCECPV------GFFYNDKLLVC---- 1806

Query: 1210 DEDSSEEDSDECR----CV-SGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
                  ED DEC+    C  +  C+   G   C+C  G++   S  +C D +EC+E+   
Sbjct: 1807 ------EDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRF-TSTGQCNDRNECQEIPN- 1858

Query: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
              +C   +C++T GSF C+C  GF  +     C+
Sbjct: 1859 --ICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCL 1890



 Score =  404 bits (1039), Expect = e-112
 Identities = 326/1156 (28%), Positives = 459/1156 (39%), Gaps = 277/1156 (23%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY-----------T 325
            G CF   +  Q C       +  +  CC ++G AWG   C  CP   +           T
Sbjct: 184  GPCFT-VISNQMCQGQLSGIVCTKTLCCATVGRAWGHP-CEMCPAQPHPCRRGFIPNIRT 241

Query: 326  GVQK--------PGPVRG-----EVGA---DCPQGYKRLN--STHCQDINECA-MPGVCR 366
            G  +        PG  +G      VG+    CP G+K LN  S  C+DI+EC+ +PG+C 
Sbjct: 242  GACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHK-LNEVSQKCEDIDECSTIPGICE 300

Query: 367  HGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQ 426
             G+C N   SY C CPPG    P  T+CI  +P     C+  ++   +C + L   +T+ 
Sbjct: 301  GGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRP---GYCYTALT-NGRCSNQLPQSITKM 356

Query: 427  LCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG 486
             CCC  G+ W        + G     E+CP               I+   DF+       
Sbjct: 357  QCCCDAGRCW--------SPGVTVAPEMCP---------------IRATEDFNKLC---- 389

Query: 487  PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRP 546
               P  +P  P   PPP             P+          P     P  P    I  P
Sbjct: 390  -SVPMVIPGRPEYPPPPL-----------GPIP---------PVLPVPPGFPPGPQIPVP 428

Query: 547  SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYR 606
             PP     +  L PSR    + P  V  TD C+L + +C +G C+P P    C CN G++
Sbjct: 429  RPP-----VEYLYPSREPPRVLPVNV--TDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQ 481

Query: 607  SHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK 666
               +   C+DV+ECE  PC  G   C+N  GSY C C  GY+  +      C D++EC +
Sbjct: 482  LDLRGE-CIDVDECEKNPCAGGE--CINNQGSYTCQCRAGYQSTLTR--TECRDIDECLQ 536

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726
                 + G CIN  G + C C  G+ +       CED+DEC   + C +G C N+ GSFK
Sbjct: 537  NGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN-CEDMDECSIRNMCLNGMCINEDGSFK 595

Query: 727  CIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
            CI C+PG++ +  G  C+D+NEC     C  G C N  GS+RC C  G A   DGR C+D
Sbjct: 596  CI-CKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVD 654

Query: 786  V-------------------------DEC-------EAGDVCD----------NGICSNT 803
                                       EC         G+ C             +CS+ 
Sbjct: 655  THMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG 714

Query: 804  PG----------------------------SFQCQCLSGYHLSRDRSHCEDIDECDFPA- 834
            PG                            +++C C SGY +     +C DI+EC   + 
Sbjct: 715  PGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSL 774

Query: 835  ACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             C  G C NT GS+ C CP+G       K C+DIDEC   P +   +G CKN  GS++C 
Sbjct: 775  LCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCI---NGVCKNSPGSFICE 831

Query: 894  CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDH 953
            C    T    +  C E      K  C+    D   C+  +     + +CC SLGA WG  
Sbjct: 832  CSSESTLDPTKTICIET----IKGTCWQTVIDG-RCEININGATLKSQCCSSLGAAWGSP 886

Query: 954  CEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNT 1013
            C +         +   +C  GKGY++             DIDEC +F   +CK G CVNT
Sbjct: 887  CTL--------CQVDPIC--GKGYSRIKG------TQCEDIDECEVFPG-VCKNGLCVNT 929

Query: 1014 QPGYECYCKQGFYYDGNLLECVDV-----------DEC---------LDESNCRNGVCEN 1053
            +  ++C C  G   D     C+D+           +EC         +D   C  G    
Sbjct: 930  RGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWG 989

Query: 1054 TRGGYRCACTPPAEYSP--------AQRQCLS--PEEMDVDECQ-DPAACRPGRCVNLPG 1102
            T     C      EY          A ++  +  P   D++EC+  P+ C  G+C N  G
Sbjct: 990  TEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIG 1049

Query: 1103 SYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC 1162
            S++C C   +      R+C    +  +      D+C                        
Sbjct: 1050 SFKCRCDSGFALDSEERNC----TDIDECRISPDLC------------------------ 1081

Query: 1163 CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR 1222
                GRG   QC   P       C   +   + F      ++ K   D D  + D   CR
Sbjct: 1082 ----GRG---QCVNTP---GDFECKCDEGYESGF------MMMKNCMDIDECQRDPLLCR 1125

Query: 1223 CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1282
               G C    G   CECP G QL  + + C+DI+EC EL+    LC + RCVN  G ++C
Sbjct: 1126 --GGVCHNTEGSYRCECPPGHQLSPNISACIDINEC-ELSAH--LCPNGRCVNLIGKYQC 1180

Query: 1283 VCKAGFARSRPHGACV 1298
             C  G+  +     CV
Sbjct: 1181 ACNPGYHSTPDRLFCV 1196



 Score =  400 bits (1028), Expect = e-111
 Identities = 235/747 (31%), Positives = 336/747 (44%), Gaps = 100/747 (13%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC++  ++C HG+C      + C C+ G+    + R C D++EC   P   GRG C+
Sbjct: 1028 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCV 1087

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693
            NT G + C C+ GY        ++C+D++EC +  L   GG C N  G Y+C C PG++L
Sbjct: 1088 NTPGDFECKCDEGYESGF-MMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQL 1146

Query: 694  KASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEG 751
             +     C DI+EC      CP+G+C N  G ++C AC PGY S      C D++EC+  
Sbjct: 1147 -SPNISACIDINECELSAHLCPNGRCVNLIGKYQC-ACNPGYHSTPDRLFCVDIDECSIM 1204

Query: 752  SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDNGICSNTPGSFQCQ 810
            +     +C N  GS+ C+C  G+A  PD RSC D+DECE   ++CD G C+N PG ++C 
Sbjct: 1205 NGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCL 1264

Query: 811  CLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDID 868
            C  G+  S D   C D++ECD  P  C+ G C NT GS+ C C  G+    G+  C DI+
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDIN 1324

Query: 869  ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            EC      C  H  C N  GS+ C C  G+    D   C ++++                
Sbjct: 1325 ECEIGAHNCGKHAVCTNTAGSFKCSCSPGW--IGDGIKCTDLDE---------------- 1366

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988
            C +   T++  Q   C    G                 +  LC +  GYT D        
Sbjct: 1367 CSN--GTHMCSQHADCKNTMG----------------SYRCLCKE--GYTGDGFTCT--- 1403

Query: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048
                D+DEC      +C  G+C+N   GY C C  GF    +   C D+DEC   + C  
Sbjct: 1404 ----DLDECS-ENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVF 1458

Query: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCEC 1108
            G C N  G +RC C    E   +   C      DV+EC DP  C  G CVN PGSY C+C
Sbjct: 1459 GTCHNLPGLFRCECEIGYELDRSGGNC-----TDVNECLDPTTCISGNCVNTPGSYICDC 1513

Query: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCW---SQRGEDG--MCAGPLAGPALTFDDCC 1163
             P +   P+   C            R   C+     RG++G   C+  + G  ++   CC
Sbjct: 1514 PPDFELNPTRVGC---------VDTRSGNCYLDIRPRGDNGDTACSNEI-GVGVSKASCC 1563

Query: 1164 CRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
            C  G+ WG  C  CP      +   CP  +              G  P       ED DE
Sbjct: 1564 CSLGKAWGTPCEMCPAVNTSEYKILCPGGE--------------GFRPNPITVILEDIDE 1609

Query: 1221 CR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1275
            C+     C  G+C+   G   C CP G+ L+     C D++EC        +C    C N
Sbjct: 1610 CQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPG----ICGPGTCYN 1665

Query: 1276 TSGSFRCVCKAGFARSRPHGACVPQRR 1302
            T G++ C+C   + +      C+  RR
Sbjct: 1666 TVGNYTCICPPDYMQVNGGNNCMDMRR 1692



 Score =  379 bits (974), Expect = e-105
 Identities = 258/813 (31%), Positives = 347/813 (42%), Gaps = 184/813 (22%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + DECR    +C +G C+     + C C  G+  + +   C D++EC+  P       C+
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI 1825

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYR 692
            NT GSY C C  GYR         C D NEC + P++C  G  CI+  G + C C+ G++
Sbjct: 1826 NTAGSYRCDCKPGYRF---TSTGQCNDRNECQEIPNICSHGQ-CIDTVGSFYCLCHTGFK 1881

Query: 693  LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752
                +  +C DI+EC +  +C +G C N  GSF C  C  G+       C DV+ECA G+
Sbjct: 1882 TNDDQ-TMCLDINEC-ERDACGNGTCRNTIGSFNC-RCNHGFILSHNNDCIDVDECASGN 1938

Query: 753  P--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNGICSNTPGSFQC 809
               C  G C N  GSF+C C +GY  APDGR+C+D++EC      C  G C N  GS++C
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC 1998

Query: 810  QCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDI 867
             C  GY L  ++  CEDIDEC + P  C  G C NT GS++CLCP+G  L   GR+CQD 
Sbjct: 1999 ICPPGYSLQNEK--CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQD- 2055

Query: 868  DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV 927
                              L+ SY                            CY  F+   
Sbjct: 2056 ------------------LRMSY----------------------------CYAKFEGGK 2069

Query: 928  FCDSVLATNVTQQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT--QDNNIV 984
             C S  + N ++QECCC+L G GWGD CE+  CP      F  +CP G G     D++ V
Sbjct: 2070 -CSSPKSRNHSKQECCCALKGEGWGDPCEL--CPTEPDEAFRQICPYGSGIIVGPDDSAV 2126

Query: 985  NYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044
                    D+DEC     ++CK G+C+NT   Y C C  G+   GN  ECVD DEC   +
Sbjct: 2127 --------DMDECK--EPDVCKHGQCINTDGSYRCECPFGYILAGN--ECVDTDECSVGN 2174

Query: 1045 NCRNGVCENTRGGYRCACTPPAEYSP-------------------------AQRQCLSPE 1079
             C NG C+N  GG+ C C    E  P                            +C  P 
Sbjct: 2175 PCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPV 2234

Query: 1080 EMDVDE----CQDPAACRPGR---------CVNLPGSYRCECRPPWVPGPSGRDCQLPES 1126
               + E    C+D   C  G+         C NL G+Y C C P +   P G  C + E+
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGC-VDEN 2293

Query: 1127 PAERAPE--RRDVCWSQRG------EDGMCAGPLAGPAL--------------------- 1157
              +  P       C + RG       DG  A P     L                     
Sbjct: 2294 ECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSS 2353

Query: 1158 -----TFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPR 1209
                 T  +CCC  GRGWG  C  CP +G  +    CP                     R
Sbjct: 2354 NRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHG-------------------R 2394

Query: 1210 DEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
               ++  D DEC+     C +G CV   G   C C  G+  D +   CVD++EC   NQ 
Sbjct: 2395 GFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNEC---NQA 2451

Query: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
               C +  C NT GS++C C  G+       +C
Sbjct: 2452 PKPC-NFICKNTEGSYQCSCPKGYILQEDGRSC 2483



 Score =  370 bits (951), Expect = e-102
 Identities = 262/821 (31%), Positives = 361/821 (43%), Gaps = 144/821 (17%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGRGI 631
            + +EC LN NIC  G C      + CHC+ GY        C D+NECE  A  CG    +
Sbjct: 1280 DVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGK-HAV 1338

Query: 632  CMNTGGSYNCHCNRG---------------------------------YRLHVGAG---- 654
            C NT GS+ C C+ G                                 YR     G    
Sbjct: 1339 CTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGD 1398

Query: 655  GRSCVDLNECAKP-HLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSC 713
            G +C DL+EC++  +LCG+G  C+N PG Y+C C  G+ + ++    CEDIDEC  P+ C
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQ-CLNAPGGYRCECDMGF-VPSADGKACEDIDECSLPNIC 1456

Query: 714  PDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQ 772
              G C N PG F+C  C+ GY   + GG C DVNEC + + C  G C N PGS+ C C  
Sbjct: 1457 VFGTCHNLPGLFRC-ECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPP 1515

Query: 773  GYAPAPDGRSCLD-------VDECEAGDVCDNGICSNTPG----------------SFQC 809
             +   P    C+D       +D    GD  D   CSN  G                   C
Sbjct: 1516 DFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTA-CSNEIGVGVSKASCCCSLGKAWGTPC 1574

Query: 810  QCLSGYHLSRDRSHC---------------EDIDEC-DFPAACIGGDCINTNGSYRCLCP 853
            +     + S  +  C               EDIDEC + P  C GG CINT GS++C CP
Sbjct: 1575 EMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCP 1634

Query: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
             G+ L    R C D++EC + P +C P G C N  G+Y C+C   +      + C ++  
Sbjct: 1635 TGYYLNEDTRVCDDVNEC-ETPGICGP-GTCYNTVGNYTCICPPDYMQVNGGNNCMDMR- 1691

Query: 913  PHHKKECYLNF-DDTVFCDSVLATNVTQQECCCS--LGAGWGDHCEIYPCPVYSSAEFHS 969
               +  CY N+  D   CD  L  N+T++ CCCS  +G  W   CE   CP+ S+ EF +
Sbjct: 1692 ---RSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCE--QCPIPSTDEFAT 1746

Query: 970  LCPDGK-GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028
            LC   + G+  D   +  G+P   DIDEC      +C+ G C+N    + C C  GF+Y+
Sbjct: 1747 LCGSQRPGFVID---IYTGLPV--DIDECREIPG-VCENGVCINMVGSFRCECPVGFFYN 1800

Query: 1029 GNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087
              LL C D+DEC +   C RN  C NT G YRC C P   ++ +  QC      D +ECQ
Sbjct: 1801 DKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFT-STGQC-----NDRNECQ 1854

Query: 1088 D-PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDG 1146
            + P  C  G+C++  GS+ C C   +        C L  +  ER       C +  G   
Sbjct: 1855 EIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMC-LDINECERDACGNGTCRNTIGSFN 1913

Query: 1147 MCAGPLAGPALTFDDCC-----CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSP 1201
                   G  L+ ++ C     C  G G   +   C        C     + N  ++ +P
Sbjct: 1914 CRCN--HGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQC-----QCNEGYEVAP 1966

Query: 1202 LLLGKPPRDEDSSEEDSDEC-----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDID 1256
                     +  +  D +EC     +C  G C    G   C CP G+ L     +C DID
Sbjct: 1967 ---------DGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSL--QNEKCEDID 2015

Query: 1257 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            EC E  +   +C    C NT GSF+C+C  GF+ S     C
Sbjct: 2016 ECVEEPE---ICALGTCSNTEGSFKCLCPEGFSLSSSGRRC 2053



 Score =  350 bits (897), Expect = 7e-96
 Identities = 244/802 (30%), Positives = 323/802 (40%), Gaps = 163/802 (20%)

Query: 574  ETDECRL-NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
            + DEC   N N+C +G+C+     + C CN GY   P  R CVD+NEC  EP     G C
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTC 1989

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691
             N  GSY C C  GY L        C D++EC  +P +C   G C N  G +KC C  G+
Sbjct: 1990 QNLDGSYRCICPPGYSLQ----NEKCEDIDECVEEPEICA-LGTCSNTEGSFKCLCPEGF 2044

Query: 692  RLKASRPPVCEDIDECRDPSSCPDGKCEN-KPGSFKCIACQPGYRSQGGG---------- 740
             L +S    C+D+      +    GKC + K  +     C    + +G G          
Sbjct: 2045 SLSSSGRR-CQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEP 2103

Query: 741  --------------------ACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780
                                +  D++EC E   C  G C N  GS+RC C  GY  A  G
Sbjct: 2104 DEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILA--G 2161

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840
              C+D DEC  G+ C NG C N  G F+C C  G+        CEDI+EC          
Sbjct: 2162 NECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFE-PGPMMTCEDINECAQNPLLCAFR 2220

Query: 841  CINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCL-PHGACKNLQGSYVCVCDEGF 898
            C+NT GSY C CP G+ L   R+ C+D DEC +    C      CKNL G+Y+C+C  G+
Sbjct: 2221 CVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGY 2280

Query: 899  TPTQDQHGCEEVEQPHHK------------------------------KECYLNFDDTVF 928
                D  GC +  +   K                               EC  N +   F
Sbjct: 2281 QRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCF 2340

Query: 929  CD---------SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ 979
             +         S     VT+ ECCC  G GWG HCEI  CP   +  F  LCP G+G+  
Sbjct: 2341 TEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEI--CPFQGTVAFKKLCPHGRGFMT 2398

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039
            +            DIDEC +   ++C+ G+CVN +  Y C CK G+  D     CVD++E
Sbjct: 2399 NG----------ADIDECKVI-HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNE 2447

Query: 1040 CLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVN 1099
            C       N +C+NT G Y+C+C          R C      D+DEC          CVN
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC-----KDLDECATKQHNCQFLCVN 2502

Query: 1100 LPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTF 1159
              G + C+C P +         Q   S  +      D+  +  G  G+C         T 
Sbjct: 2503 TIGGFTCKCPPGFT--------QHHTSCIDNNECTSDI--NLCGSKGICQN-------TP 2545

Query: 1160 DDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSD 1219
                C   RG+            GS C                             ED D
Sbjct: 2546 GSFTCECQRGFSLD-------QTGSSC-----------------------------EDVD 2569

Query: 1220 EC----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1275
            EC    RC  G C    GG  C CP G+       +CVD +EC   +    +C    C N
Sbjct: 2570 ECEGNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAH----ICGGASCHN 2624

Query: 1276 TSGSFRCVCKAGFARSRPHGAC 1297
            T GS++C+C AGF   +  G C
Sbjct: 2625 TLGSYKCMCPAGFQYEQFSGGC 2646



 Score =  332 bits (850), Expect = 2e-90
 Identities = 242/778 (31%), Positives = 324/778 (41%), Gaps = 161/778 (20%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG----- 628
            + DEC     IC  GEC      Y C C PG+ + P    C+DV         PG     
Sbjct: 288  DIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVR--------PGYCYTA 339

Query: 629  --RGICMN----TGGSYNCHCNRGYRLHVGAGG-------RSCVDLNE-CAKPHLC---- 670
               G C N    +     C C+ G     G          R+  D N+ C+ P +     
Sbjct: 340  LTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRP 399

Query: 671  -------GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS----------- 712
                   G     +  P  +     PG ++   RPPV E +   R+P             
Sbjct: 400  EYPPPPLGPIPPVLPVPPGFP----PGPQIPVPRPPV-EYLYPSREPPRVLPVNVTDYCQ 454

Query: 713  -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFR 767
                 C +G+C   PGS +C  C  G++    G C DV+EC E +PC+ G C N  GS+ 
Sbjct: 455  LVRYLCQNGRCIPTPGSCRC-ECNKGFQLDLRGECIDVDEC-EKNPCAGGECINNQGSYT 512

Query: 768  CTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCED 826
            C C  GY        C D+DEC + G +C+NG C NT GSF C C +G+H++RD  +CED
Sbjct: 513  CQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED 572

Query: 827  IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKN 885
            +DEC     C+ G CIN +GS++C+C  G +L   GR C+DI+EC + P +C+ +G C N
Sbjct: 573  MDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINEC-ETPGICM-NGRCVN 630

Query: 886  LQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCC- 944
              GSY C C  G     D   C +    H +  CY  +     C   L   VT+ ECCC 
Sbjct: 631  TDGSYRCECFPGLAVGLDGRVCVDT---HMRSTCYGGYKRGQ-CIKPLFGAVTKSECCCA 686

Query: 945  SLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004
            S    +G+ C+  PCP  +SAE+ +LC  G G T           A  DI+EC L   +I
Sbjct: 687  STEYAFGEPCQ--PCPAQNSAEYQALCSSGPGMTS----------AGSDINECAL-DPDI 733

Query: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENTRGGYRCACT 1063
            C  G C N +  Y+C C  G+  D     CVD++EC L+   C NG C NT G + C C 
Sbjct: 734  CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCP 793

Query: 1064 PPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQL 1123
                Y P  + C      D+DEC+  + C  G C N PGS+ CEC       P+   C  
Sbjct: 794  KGFIYKPDLKTC-----EDIDECES-SPCINGVCKNSPGSFICECSSESTLDPTKTIC-- 845

Query: 1124 PESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAG 1183
                       +  CW Q   DG C   + G  L    CC   G  WG            
Sbjct: 846  -------IETIKGTCW-QTVIDGRCEININGATLK-SQCCSSLGAAWG------------ 884

Query: 1184 SHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGF 1243
            S C   Q +                               + G+   R  G  CE     
Sbjct: 885  SPCTLCQVDP------------------------------ICGKGYSRIKGTQCE----- 909

Query: 1244 QLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301
                      DIDEC        +CK+  CVNT GSF+C C +G         C+  R
Sbjct: 910  ----------DIDECEVFPG---VCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954



 Score =  283 bits (723), Expect = 1e-75
 Identities = 234/825 (28%), Positives = 323/825 (39%), Gaps = 161/825 (19%)

Query: 573  TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
            ++ +EC L+ +IC +G C      Y C CN GY      + CVD+NEC         G C
Sbjct: 722  SDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQC 781

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGY 691
             NT GS+ C C +G+        ++C D++EC + P +    G C N PG + C C    
Sbjct: 782  RNTPGSFVCTCPKGFIYKPDL--KTCEDIDECESSPCI---NGVCKNSPGSFICECSSES 836

Query: 692  RLKASRPPVCEDIDECRDPSSCPDGKCE-NKPGS---------------FKCIACQ---- 731
             L  ++  +C +  +     +  DG+CE N  G+                 C  CQ    
Sbjct: 837  TLDPTK-TICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPI 895

Query: 732  --PGYRSQGGGACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV- 786
               GY    G  C D++EC E  P  C  G C N  GSF+C C  G      GR CLD+ 
Sbjct: 896  CGKGYSRIKGTQCEDIDEC-EVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954

Query: 787  ---------DE----------------CEAG-----DVCDNGICSNTPGSFQCQCLSG-- 814
                     DE                C  G     + C+     NTP  ++  C  G  
Sbjct: 955  LETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTP-EYEELCPRGPG 1013

Query: 815  ---YHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDE 869
                 ++  +   +DI+EC   P+ C  G C NT GS++C C  G  L    R C DIDE
Sbjct: 1014 FATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDE 1073

Query: 870  CSQDPSLCLPHGACKNLQGSYVCVCDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            C   P LC   G C N  G + C CDEG+ +       C +++      EC     D + 
Sbjct: 1074 CRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMMKNCMDID------ECQ---RDPLL 1123

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988
            C   +  N      C               CP       H L P+              I
Sbjct: 1124 CRGGVCHNTEGSYRC--------------ECP-----PGHQLSPN--------------I 1150

Query: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048
             A  DI+EC L  + +C  G+CVN    Y+C C  G++   + L CVD+DEC   +    
Sbjct: 1151 SACIDINECEL-SAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCE 1209

Query: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRCE 1107
              C N+ G Y C+C P     P QR C      D+DEC+D P  C  G+C N+PG YRC 
Sbjct: 1210 TFCTNSEGSYECSCQPGFALMPDQRSC-----TDIDECEDNPNICDGGQCTNIPGEYRCL 1264

Query: 1108 CRPPWVPGPSGRDC----------QLPESPAERAPERRDVCWSQRGEDGM-----C---- 1148
            C   ++     + C           +  S      +   +C    G  G      C    
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDIN 1324

Query: 1149 --------AGPLAGPALTFDDCCCRQGRGW---GAQCRPCPPRGAGSHCPTSQSESNSFW 1197
                     G  A    T     C    GW   G +C        G+H  +  ++  +  
Sbjct: 1325 ECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTM 1384

Query: 1198 DTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARC 1252
             +   L  +    +  +  D DEC      C +G+C+  PGG  CEC  GF   A    C
Sbjct: 1385 GSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKAC 1444

Query: 1253 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
             DIDEC   N    +C    C N  G FRC C+ G+   R  G C
Sbjct: 1445 EDIDECSLPN----ICVFGTCHNLPGLFRCECEIGYELDRSGGNC 1485



 Score =  283 bits (723), Expect = 1e-75
 Identities = 243/904 (26%), Positives = 348/904 (38%), Gaps = 229/904 (25%)

Query: 573  TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNE----CEAEPCGP- 627
            T+ +EC L+   C  G CV  P  Y C C P +  +P    CVD        +  P G  
Sbjct: 1486 TDVNEC-LDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDN 1544

Query: 628  GRGICMNTGG----SYNCHCNRG-----------------YRLHV--GAGGRS------C 658
            G   C N  G      +C C+ G                 Y++    G G R        
Sbjct: 1545 GDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVIL 1604

Query: 659  VDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGK 717
             D++EC + P LC  GG CIN  G ++C C  GY L      VC+D++EC  P  C  G 
Sbjct: 1605 EDIDECQELPGLC-QGGKCINTFGSFQCRCPTGYYLNEDTR-VCDDVNECETPGICGPGT 1662

Query: 718  CENKPGSFKCIACQPGYRS-QGGGACRDV-------NECAEGSPCSPGWCENLPGSFRCT 769
            C N  G++ CI C P Y    GG  C D+       N  A+   C      N+     C 
Sbjct: 1663 CYNTVGNYTCI-CPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCC 1721

Query: 770  -----------CAQGYAPAPDGRSCL------------------DVDEC-EAGDVCDNGI 799
                       C Q   P+ D  + L                  D+DEC E   VC+NG+
Sbjct: 1722 SYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGV 1781

Query: 800  CSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNGSYRCLCPQGHRL 858
            C N  GSF+C+C  G+  +     CEDIDEC     C    +CINT GSYRC C  G+R 
Sbjct: 1782 CINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRF 1841

Query: 859  VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
                +C D +EC + P++C  HG C +  GS+ C+C  GF    DQ  C ++       E
Sbjct: 1842 TSTGQCNDRNECQEIPNIC-SHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDIN------E 1894

Query: 919  CYLNFDDTVFCDSVLATNVTQQECCCSLG----------------AGWGDHCEIYPCPVY 962
            C  +      C + + +      C C+ G                +G G+ C    C + 
Sbjct: 1895 CERDACGNGTCRNTIGSF----NCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQC-IN 1949

Query: 963  SSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCK 1022
            +   F   C +G     D            DI+EC+L   + C  G C N    Y C C 
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCV-------DINECLLEPRK-CAPGTCQNLDGSYRCICP 2001

Query: 1023 QGFYYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCA-------------------- 1061
             G+       +C D+DEC++E   C  G C NT G ++C                     
Sbjct: 2002 PGYSLQNE--KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMS 2059

Query: 1062 ----------CTPPAEYSPAQRQC--------------LSPEE----------------- 1080
                      C+ P   + ++++C              L P E                 
Sbjct: 2060 YCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIV 2119

Query: 1081 ------MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPER 1134
                  +D+DEC++P  C+ G+C+N  GSYRCEC  P+    +G +C   +  +   P  
Sbjct: 2120 GPDDSAVDMDECKEPDVCKHGQCINTDGSYRCEC--PFGYILAGNECVDTDECSVGNPCG 2177

Query: 1135 RDVCWSQRG------EDGMCAGPLAGPALTFDD----------CCCRQGRGWGA-QCRPC 1177
               C +  G      E+G   GP+    +T +D          C  R    +G+ +C+  
Sbjct: 2178 NGTCKNVIGGFECTCEEGFEPGPM----MTCEDINECAQNPLLCAFRCVNTYGSYECK-- 2231

Query: 1178 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVC 1237
                    CP                  +  +DED  EE   +C      C    G  +C
Sbjct: 2232 --------CPVGYVLRED---------RRMCKDEDECEEGKHDCTEKQMECKNLIGTYMC 2274

Query: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
             C  G+Q       CVD +EC+    +  +C++ RC+NT GS+ C C  GF  S     C
Sbjct: 2275 ICGPGYQRRPDGEGCVDENECQT---KPGICENGRCLNTRGSYTCECNDGFTASPNQDEC 2331

Query: 1298 VPQR 1301
            +  R
Sbjct: 2332 LDNR 2335



 Score =  259 bits (663), Expect = 9e-69
 Identities = 238/858 (27%), Positives = 325/858 (37%), Gaps = 173/858 (20%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPG--VCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            G     C  G+   ++  C D++ECA     +CR+G C+N  GS++C C  G+ + P   
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969

Query: 393  QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT-DGTAAF 451
             C+     + + C  L+ P                C C  G  +  + ++C   D     
Sbjct: 1970 TCV-----DINEC--LLEPRKCAPGTCQNLDGSYRCICPPG--YSLQNEKCEDIDECVEE 2020

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
             EIC  G   +   S + L  +G   FSL        + Q L  S   A       +  G
Sbjct: 2021 PEICALGTCSNTEGSFKCLCPEG---FSL---SSSGRRCQDLRMSYCYA-------KFEG 2067

Query: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQ 571
                SP S   S Q+              EL         R     + P  S + + P  
Sbjct: 2068 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFR----QICPYGSGIIVGPDD 2123

Query: 572  -VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA-EPCGPGR 629
               + DEC+   ++C HG+C+     Y C C  GY        CVD +EC    PCG   
Sbjct: 2124 SAVDMDECK-EPDVCKHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCG--N 2178

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCY 688
            G C N  G + C C  G+         +C D+NECA+ P LC     C+N  G Y+C C 
Sbjct: 2179 GTCKNVIGGFECTCEEGFE---PGPMMTCEDINECAQNPLLCAFR--CVNTYGSYECKCP 2233

Query: 689  PGYRLKASRPPVCEDIDECRDPS-SCPDGK--CENKPGSFKCIACQPGY-RSQGGGACRD 744
             GY L+  R  +C+D DEC +    C + +  C+N  G++ CI C PGY R   G  C D
Sbjct: 2234 VGYVLREDRR-MCKDEDECEEGKHDCTEKQMECKNLIGTYMCI-CGPGYQRRPDGEGCVD 2291

Query: 745  VNECA-----------------------EGSPCSP----------GWC------------ 759
             NEC                        +G   SP          G+C            
Sbjct: 2292 ENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIG 2351

Query: 760  ---ENLPGSFRCTC--AQGYAP----------------APDGRSCL----DVDECEA-GD 793
                N      C C   +G+ P                 P GR  +    D+DEC+   D
Sbjct: 2352 SSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHD 2411

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
            VC NG C N  GS+ C C +GY      + C D++EC+         C NT GSY+C CP
Sbjct: 2412 VCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCP 2471

Query: 854  QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
            +G+ L   GR C+D+DEC+     C     C N  G + C C  GFT             
Sbjct: 2472 KGYILQEDGRSCKDLDECATKQHNC--QFLCVNTIGGFTCKCPPGFT------------- 2516

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
              H   C  N + T           +    C S G      C+  P        F   C 
Sbjct: 2517 -QHHTSCIDNNECT-----------SDINLCGSKGI-----CQNTP------GSFTCECQ 2553

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL 1032
             G    Q  +       +  D+DEC   G+  C+ G C N   GY C C QG+       
Sbjct: 2554 RGFSLDQTGS-------SCEDVDECE--GNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWN 2603

Query: 1033 ECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAAC 1092
            +CVD +ECL    C    C NT G Y+C C    +Y      C      D++EC    A 
Sbjct: 2604 QCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGC-----QDINECGSAQAP 2658

Query: 1093 RPGRCVNLPGSYRCECRP 1110
                C N  G Y C C P
Sbjct: 2659 CSYGCSNTEGGYLCGCPP 2676



 Score =  239 bits (609), Expect = 2e-62
 Identities = 170/546 (31%), Positives = 236/546 (43%), Gaps = 57/546 (10%)

Query: 333  VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            V G     C +G++      C+DINECA   +     C+N  GSY C CP G+ L   R 
Sbjct: 2184 VIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRR 2243

Query: 393  QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFK 452
             C  D+ E +         + +C++ + T     +C C  G       + C  +     K
Sbjct: 2244 MC-KDEDECEEGKHDCTEKQMECKNLIGT----YMCICGPGYQRRPDGEGCVDENECQTK 2298

Query: 453  E-ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
              IC  G+    L +  + T +    F+                SP+Q    E  +   G
Sbjct: 2299 PGICENGR---CLNTRGSYTCECNDGFTA---------------SPNQ---DECLDNREG 2337

Query: 512  VTTDSPVSEERSVQQSHPTATTTPA---------RPYPELISRPSPPTMRWFLPDLPPSR 562
                  +     +  S+    T             P+ E+   P   T+  F    P  R
Sbjct: 2338 YCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEIC--PFQGTVA-FKKLCPHGR 2394

Query: 563  SAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA 622
              +    T   + DEC++  ++C +GECV     Y C C  GY        CVD+NEC  
Sbjct: 2395 GFM----TNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQ 2450

Query: 623  EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPG 681
             P  P   IC NT GSY C C +GY L     GRSC DL+ECA K H C     C+N  G
Sbjct: 2451 AP-KPCNFICKNTEGSYQCSCPKGYILQ--EDGRSCKDLDECATKQHNCQF--LCVNTIG 2505

Query: 682  HYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPD-GKCENKPGSFKCIACQPGYR-SQG 738
             + C C PG+         C D +EC  D + C   G C+N PGSF C  CQ G+   Q 
Sbjct: 2506 GFTCKCPPGF---TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTC-ECQRGFSLDQT 2561

Query: 739  GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG 798
            G +C DV+EC     C  G C+N+ G +RC+C QGY        C+D +EC +  +C   
Sbjct: 2562 GSSCEDVDECEGNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGA 2620

Query: 799  ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL 858
             C NT GS++C C +G+   +    C+DI+EC    A     C NT G Y C CP G+  
Sbjct: 2621 SCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFR 2680

Query: 859  VGGRKC 864
            +G   C
Sbjct: 2681 IGQGHC 2686



 Score =  214 bits (545), Expect = 4e-55
 Identities = 221/843 (26%), Positives = 309/843 (36%), Gaps = 206/843 (24%)

Query: 572  VTETDECRLNQNICGHGECVPGP----PDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP 627
            V ET   R  +   G  + + GP      Y+ +C PG+++ P    C+ V  C    CG 
Sbjct: 34   VKETRASRAKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCI-VPICR-HSCGD 91

Query: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687
            G   C        C C  G ++    G RS    N       C +GG C +      C C
Sbjct: 92   G--FCSRPN---MCTCPSG-QIAPSCGSRSIQHCNI-----RCMNGGSCSDD----HCLC 136

Query: 688  YPGYRLKASRPPVCE----DIDECRDPSSCP------DGKCENKPGSFKCIACQPGYRSQ 737
              GY       PVCE    +   C  P+ C         +CE    +  C         Q
Sbjct: 137  QKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQ 196

Query: 738  G---GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GD 793
            G   G  C     CA         CE  P      C +G+ P     +C DVDEC+A   
Sbjct: 197  GQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPH-PCRRGFIPNIRTGACQDVDECQAIPG 255

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLC 852
            +C  G C NT GSF+C+C +G+ L+     CEDIDEC   P  C GG+C NT  SY C C
Sbjct: 256  LCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKC 315

Query: 853  PQG-HRLVGGRKCQDIDECSQDPSLC---LPHGACKNLQGSYVCVCDEGFTPTQDQHGCE 908
            P G +    G +C D+      P  C   L +G C N                       
Sbjct: 316  PPGFYTSPDGTRCIDV-----RPGYCYTALTNGRCSN----------------------- 347

Query: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP--CPVYSSAE 966
            ++ Q   K +C                       CC  G  W     + P  CP+ ++ +
Sbjct: 348  QLPQSITKMQC-----------------------CCDAGRCWSPGVTVAPEMCPIRATED 384

Query: 967  FHSLC------------------------------PDGKGYTQDNNIVNYGIPAHRD--- 993
            F+ LC                              P G         V Y  P+      
Sbjct: 385  FNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRV 444

Query: 994  -----IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048
                  D C L    +C+ G+C+ T     C C +GF  D    EC+DVDEC +++ C  
Sbjct: 445  LPVNVTDYCQLV-RYLCQNGRCIPTPGSCRCECNKGFQLDLR-GECIDVDEC-EKNPCAG 501

Query: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSYRCE 1107
            G C N +G Y C C    + +  + +C      D+DEC Q+   C  GRC+N  GS+ C 
Sbjct: 502  GECINNQGSYTCQCRAGYQSTLTRTEC-----RDIDECLQNGRICNNGRCINTDGSFHCV 556

Query: 1108 CRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG-------------EDGM------- 1147
            C   +     G++C+  +  + R      +C ++ G              DG        
Sbjct: 557  CNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE 616

Query: 1148 CAGP---LAGPALTFDD---CCCRQGRGWGAQCRPCPPRGAGSHCP-------------T 1188
            C  P   + G  +  D    C C  G   G   R C      S C               
Sbjct: 617  CETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676

Query: 1189 SQSESNSFWDTSPLLLGKP--PRDEDSSEE----------------DSDECR-----CVS 1225
            + ++S     ++    G+P  P    +S E                D +EC      C +
Sbjct: 677  AVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPN 736

Query: 1226 GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCK 1285
            G C    G   C C  G+++D++   CVDI+EC  LN   LLC + +C NT GSF C C 
Sbjct: 737  GICENLRGTYKCICNSGYEVDSTGKNCVDINEC-VLN--SLLCDNGQCRNTPGSFVCTCP 793

Query: 1286 AGF 1288
             GF
Sbjct: 794  KGF 796



 Score =  208 bits (530), Expect = 2e-53
 Identities = 156/504 (30%), Positives = 208/504 (41%), Gaps = 75/504 (14%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGI 631
            + +EC  N  +C    CV     Y C C  GY      R C D +ECE     C   +  
Sbjct: 2206 DINECAQNPLLCAF-RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQME 2264

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690
            C N  G+Y C C  GY+      G  CVD NEC  KP +C + G C+N  G Y C C  G
Sbjct: 2265 CKNLIGTYMCICGPGYQRR--PDGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECNDG 2321

Query: 691  YRLKASRPP----------------VCEDIDECRDPSS----CPDG------KCENKPG- 723
            +    ++                  +C+     R+P +    C DG       CE  P  
Sbjct: 2322 FTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQ 2381

Query: 724  ---SFKCIACQPGYRSQGGGACRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPAPD 779
               +FK + C  G      GA  D++EC      C  G C N  GS+ C C  GY P   
Sbjct: 2382 GTVAFKKL-CPHGRGFMTNGA--DIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDIT 2438

Query: 780  GRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGG 839
            G SC+D++EC       N IC NT GS+QC C  GY L  D   C+D+DEC         
Sbjct: 2439 GTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQF 2498

Query: 840  DCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT 899
             C+NT G + C CP G        C D +EC+ D +LC   G C+N  GS+ C C  GF+
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQ-HHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFS 2557

Query: 900  PTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGA----GWG---D 952
              Q    CE+V++      C         C +++        C C  G      W    D
Sbjct: 2558 LDQTGSSCEDVDECEGNHRCQHG------CQNIIGG----YRCSCPQGYLQHYQWNQCVD 2607

Query: 953  HCEIYPCPVYSSAEFHS-------LCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC 1005
              E     +   A  H+       +CP G  Y Q +          +DI+EC    +  C
Sbjct: 2608 ENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSG-------GCQDINECGSAQAP-C 2659

Query: 1006 KEGKCVNTQPGYECYCKQGFYYDG 1029
              G C NT+ GY C C  G++  G
Sbjct: 2660 SYG-CSNTEGGYLCGCPPGYFRIG 2682



 Score =  109 bits (272), Expect = 2e-23
 Identities = 66/189 (34%), Positives = 84/189 (44%), Gaps = 10/189 (5%)

Query: 570  TQVTETDECRLNQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGP 627
            T   + +EC  + N+CG  G C   P  ++C C  G+        C DV+ECE    C  
Sbjct: 2520 TSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQH 2579

Query: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687
            G   C N  G Y C C +GY  H       CVD NEC   H+CG G  C N  G YKC C
Sbjct: 2580 G---CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECLSAHICG-GASCHNTLGSYKCMC 2633

Query: 688  YPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNE 747
              G++ +      C+DI+EC    +     C N  G + C  C PGY   G G C     
Sbjct: 2634 PAGFQYEQFSGG-CQDINECGSAQAPCSYGCSNTEGGYLC-GCPPGYFRIGQGHCVSGMG 2691

Query: 748  CAEGSPCSP 756
               G+P  P
Sbjct: 2692 MGRGNPEPP 2700



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 74/267 (27%), Positives = 96/267 (35%), Gaps = 77/267 (28%)

Query: 1046 CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYR 1105
            C+NG C  T G  RC C    +        L  E +DVDEC+    C  G C+N  GSY 
Sbjct: 460  CQNGRCIPTPGSCRCECNKGFQLD------LRGECIDVDECEKNP-CAGGECINNQGSYT 512

Query: 1106 CECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC-- 1163
            C+CR  +    +  +C             RD+                      D+C   
Sbjct: 513  CQCRAGYQSTLTRTEC-------------RDI----------------------DECLQN 537

Query: 1164 ---CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
               C  GR        C       HC  +               G     +  + ED DE
Sbjct: 538  GRICNNGR--------CINTDGSFHCVCNA--------------GFHVTRDGKNCEDMDE 575

Query: 1221 CR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNT 1276
            C     C++G C+   G   C C  GFQL +    C DI+EC        +C + RCVNT
Sbjct: 576  CSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPG----ICMNGRCVNT 631

Query: 1277 SGSFRCVCKAGFARSRPHGACVPQRRR 1303
             GS+RC C  G A       CV    R
Sbjct: 632  DGSYRCECFPGLAVGLDGRVCVDTHMR 658



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 77/302 (25%), Positives = 107/302 (35%), Gaps = 49/302 (16%)

Query: 1017 YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL 1076
            Y  YC  G+       +C+ V  C    +C +G C        C C P  + +P+   C 
Sbjct: 63   YNAYCCPGWKTLPGGNQCI-VPIC--RHSCGDGFCSRPN---MCTC-PSGQIAPS---CG 112

Query: 1077 SPEEMDVD-ECQDPAACRPGRCVNLPGSYRCECRPPWVPGP--SGRDCQLPE-------- 1125
            S      +  C +  +C    C+   G     C  P       +G  C  P         
Sbjct: 113  SRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGF 172

Query: 1126 -SPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS 1184
              P      R   C++      MC G L+G   T   CC   GR WG  C  CP +    
Sbjct: 173  TGPQCERDYRTGPCFTVISNQ-MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ---- 227

Query: 1185 HCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCEC 1239
                            P   G  P     + +D DEC+     C  G C+   G   C+C
Sbjct: 228  --------------PHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKC 273

Query: 1240 PGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
            P G +L+    +C DIDEC  +     +C+   C NT  S+ C C  GF  S     C+ 
Sbjct: 274  PAGHKLNEVSQKCEDIDECSTIPG---ICEGGECTNTVSSYFCKCPPGFYTSPDGTRCID 330

Query: 1300 QR 1301
             R
Sbjct: 331  VR 332



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 65/228 (28%), Positives = 97/228 (42%), Gaps = 60/228 (26%)

Query: 277  GRCFQDTLPKQPCG----SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP 332
            G C+ D  P+   G    SN +     +  CC S+G AWG + C  CP +  +       
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWG-TPCEMCPAVNTS------- 1583

Query: 333  VRGEVGADCPQGYK-RLN--STHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGHSL- 387
               E    CP G   R N  +   +DI+EC  +PG+C+ G C+N  GS++C CP G+ L 
Sbjct: 1584 ---EYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLN 1640

Query: 388  ------------------GPSRTQ---------CIADKPE----------EKSLCFRLVS 410
                              GP             C  D  +           +SLC+R   
Sbjct: 1641 EDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYY 1700

Query: 411  PEHQ-CQHPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEIC 455
             ++Q C   L   +T+++CCCS  +G+AW   C++CP   T  F  +C
Sbjct: 1701 ADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLC 1748



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 39/127 (30%), Positives = 53/127 (41%), Gaps = 17/127 (13%)

Query: 289  CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL 348
            C S      +KQE CC   G  WG   C  CP        +P     ++   CP G   +
Sbjct: 2070 CSSPKSRNHSKQECCCALKGEGWGDP-CELCPT-------EPDEAFRQI---CPYGSGII 2118

Query: 349  --NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR----TQCIADKPEEK 402
                    D++EC  P VC+HG C+N  GSYRC CP G+ L  +      +C    P   
Sbjct: 2119 VGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGN 2178

Query: 403  SLCFRLV 409
              C  ++
Sbjct: 2179 GTCKNVI 2185



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 41/121 (33%), Positives = 57/121 (47%), Gaps = 16/121 (13%)

Query: 277  GRCFQDTLPKQ-PCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335
            G CF + L      GS+    +TK E CC   G  WG   C  CP       +K      
Sbjct: 2337 GYCFTEVLQNMCQIGSSNRNPVTKSECCCDG-GRGWGPH-CEICPFQGTVAFKKL----- 2389

Query: 336  EVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 CP G  R   T+  DI+EC  +  VCR+G+C+N+ GSY C+C  G++   + T C
Sbjct: 2390 -----CPHG--RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSC 2442

Query: 395  I 395
            +
Sbjct: 2443 V 2443



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 1/72 (1%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            G    DC  GY+  ++  C D NEC  +P +C HG C++  GS+ C+C  G      +T 
Sbjct: 1829 GSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTM 1888

Query: 394  CIADKPEEKSLC 405
            C+     E+  C
Sbjct: 1889 CLDINECERDAC 1900



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 45/146 (30%), Positives = 60/146 (41%), Gaps = 40/146 (27%)

Query: 287  QPCGSNPLPGLTKQEDCCG-SIGTAWGQSKCHKCPQ------LQYTGVQKPG-------- 331
            Q C    L  +TK+  CC  +IG AW +  C +CP           G Q+PG        
Sbjct: 1704 QTCDGELLFNMTKKMCCCSYNIGRAWNKP-CEQCPIPSTDEFATLCGSQRPGFVIDIYTG 1762

Query: 332  -PVR--------------------GEVGADCPQGYKRLNSTH-CQDINECAMPGVC-RHG 368
             PV                     G    +CP G+   +    C+DI+EC    VC R+ 
Sbjct: 1763 LPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNA 1822

Query: 369  DCLNNPGSYRCVCPPGHSLGPSRTQC 394
            +C+N  GSYRC C PG+    S  QC
Sbjct: 1823 ECINTAGSYRCDCKPGYRF-TSTGQC 1847



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 13/83 (15%)

Query: 304  CGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGY-KRLNSTHCQDINECAM 361
            C  +    G  +C H C             + G     CPQGY +      C D NEC  
Sbjct: 2565 CEDVDECEGNHRCQHGCQN-----------IIGGYRCSCPQGYLQHYQWNQCVDENECLS 2613

Query: 362  PGVCRHGDCLNNPGSYRCVCPPG 384
              +C    C N  GSY+C+CP G
Sbjct: 2614 AHICGGASCHNTLGSYKCMCPAG 2636



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 19/75 (25%)

Query: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126
           C   C+ G  C D    CQ+G   T  G+                VC   C+NGG+C + 
Sbjct: 119 CNIRCMNGGSCSDDHCLCQKGYIGTHCGQP---------------VCESGCLNGGRCVAP 163

Query: 127 NQCLCPPDFTGRFCQ 141
           N+C C   FTG  C+
Sbjct: 164 NRCACTYGFTGPQCE 178



 Score = 38.9 bits (89), Expect = 0.032
 Identities = 35/118 (29%), Positives = 43/118 (36%), Gaps = 11/118 (9%)

Query: 46  AGERGAGGGGAL-----ARERFKVVFAP----VICKRTCLKGQCRDSCQQGSNMTLIGEN 96
           A  RG GG  AL        R+     P    +     C+   CR SC  G         
Sbjct: 42  AKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCT 101

Query: 97  GHSTDTLTGSGFRVVV-CPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGG 153
             S       G R +  C + CMNGG CS  + CLC   + G  C  P   +G   GG
Sbjct: 102 CPSGQIAPSCGSRSIQHCNIRCMNGGSCSD-DHCLCQKGYIGTHCGQPVCESGCLNGG 158



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 2/48 (4%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            C  G+K  +  T C DINEC     C +G C N  GS+ C C  G  L
Sbjct: 1876 CHTGFKTNDDQTMCLDINECERDA-CGNGTCRNTIGSFNCRCNHGFIL 1922


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  226 bits (576), Expect = 1e-58
 Identities = 225/776 (28%), Positives = 316/776 (40%), Gaps = 140/776 (18%)

Query: 577  ECRLNQNICGHG-ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            EC  + ++C HG  CVPG     CHC PG++  P+ +Y  DV+EC     G  +  C+NT
Sbjct: 127  EC--SASLCFHGGRCVPGSAQ-PCHCPPGFQG-PRCQY--DVDECRTHN-GGCQHRCVNT 179

Query: 636  GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFP-GHYKCNCYPGY 691
             GSY C C  G+RLH  +  R+C+ +N CA     G+GG    C+      ++C C PG+
Sbjct: 180  PGSYLCECKPGFRLHTDS--RTCLAINSCA----LGNGGCQHHCVQLTITRHRCQCRPGF 233

Query: 692  RLKASRPPVCEDIDEC--RDPSSCPDGKCENK----PGSFKCIACQPGYR-SQGGGACRD 744
            +L+       ED   C  R P +  +G C ++     G  +C  C  GY+ +  G AC D
Sbjct: 234  QLQ-------EDGRHCVRRSPCANRNGSCMHRCQVVRGLARC-ECHVGYQLAADGKACED 285

Query: 745  VNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-----VDECEAGD-VCDN 797
            V+ECA G + C+ G C N  GSF+C C  GY    DGR C       V+ CEA +  C +
Sbjct: 286  VDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH 344

Query: 798  GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGH 856
            G CS+T     C C  GY L  D+  C D+D+C D P  C    C N  G Y C C  G+
Sbjct: 345  G-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGGYECGCYAGY 401

Query: 857  RL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            RL   G  C+D+DEC+     C  H  C NL GS+ C C+ G+   +D+ GC  +E+P  
Sbjct: 402  RLSADGCGCEDVDECASSRGGCEHH--CTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMV 459

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              +  L F   +   +VL   + Q      +GA   D  E      ++  E      D  
Sbjct: 460  DLDGELPFVRPLPHIAVLQDELPQLFQDDDVGA---DEEEAELRGEHTLTEKFVCLDDSF 516

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECV 1035
            G+                  +C L   +    G C+    G  C C +G+      L C 
Sbjct: 517  GH------------------DCSLTCDDCRNGGTCLLGLDG--CDCPEGW----TGLICN 552

Query: 1036 DV-------DECLDESNCRN-GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087
            +          C    +C+N G C++  G   C C P    +  +  C  P+      C+
Sbjct: 553  ETCPPDTFGKNCSFSCSCQNGGTCDSVTGA--CRCPPGVSGTNCEDGC--PKGYYGKHCR 608

Query: 1088 DPAAC-RPGRCVNLPGSYRCE-------CR---PPWVPGPS-GRDCQLPESPAERAPERR 1135
                C   GRC  L G+  C+       C    PPW  GP    +CQ  +   +   +R 
Sbjct: 609  KKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRD 668

Query: 1136 DVCWSQRGEDG-----MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTS- 1189
              C  + G  G      C     GP   +  C C  G    +    C     G  CP   
Sbjct: 669  GSCSCKAGFRGERCQAECELGYFGPG-CWQACTCPVGVACDSVSGEC-----GKRCPAGF 722

Query: 1190 QSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASR 1249
            Q E            G+           S  C C    C    G   C CP G   +   
Sbjct: 723  QGED----------CGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCE 770

Query: 1250 ARCVDIDECRELNQRGLLCK--------SERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            A C +        + GL C+        + RC   +G+  C+C  GF  SR    C
Sbjct: 771  ADCPE-------GRWGLGCQEICPACQHAARCDPETGA--CLCLPGFVGSRCQDVC 817



 Score =  205 bits (522), Expect = 2e-52
 Identities = 208/735 (28%), Positives = 287/735 (39%), Gaps = 121/735 (16%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + DECR +   C H  CV  P  Y C C PG+R H   R C+ +N C     G       
Sbjct: 161  DVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN----FPGHYKCNCYP 689
             T   + C C  G++L     GR CV  + CA  +     G C++      G  +C C+ 
Sbjct: 220  LTITRHRCQCRPGFQLQ--EDGRHCVRRSPCANRN-----GSCMHRCQVVRGLARCECHV 272

Query: 690  GYRLKASRPPVCEDIDECRDP-SSCPDGKCENKPGSFKCIACQPGYRSQGGGA------C 742
            GY+L A     CED+DEC    + C  G C N  GSFKC+ C  GY     G        
Sbjct: 273  GYQLAADGK-ACEDVDECAAGLAQCAHG-CLNTQGSFKCV-CHAGYELGADGRQCYRIEM 329

Query: 743  RDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICS 801
              VN C A    CS G C +      CTC +GY    D R+C+DVD+C A   C   +C+
Sbjct: 330  EIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDC-ADSPCCQQVCT 387

Query: 802  NTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGG 861
            N PG ++C C +GY LS D   CED+DEC          C N  GS++C C  G+RL   
Sbjct: 388  NNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHED 447

Query: 862  RK-CQDIDECSQDPS------LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPH 914
            R+ C  ++E   D          LPH A   LQ     +  +      ++    E+   H
Sbjct: 448  RRGCSPLEEPMVDLDGELPFVRPLPHIAV--LQDELPQLFQDDDVGADEEEA--ELRGEH 503

Query: 915  HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPV-YSSAEFHSLCPD 973
               E ++  DD+   D  L  +  +    C LG    D C+   CP  ++    +  CP 
Sbjct: 504  TLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGL---DGCD---CPEGWTGLICNETCPP 557

Query: 974  ---GKGYTQDNNIVNYGIPAHRDIDEC-MLFGSEICKEG-KCVNTQPGYECYCKQGFYYD 1028
               GK  +   +  N G         C  + G+  C  G    N + G    C +G+Y  
Sbjct: 558  DTFGKNCSFSCSCQNGG--------TCDSVTGACRCPPGVSGTNCEDG----CPKGYYGK 605

Query: 1029 GNLLECVDVDECLDESNCRN--GVCENTRGGYRCAC---TPPAEYSPA---QRQCLSPEE 1080
                +C     C +   C    G C    G Y   C    PP  + P    + QC+ P  
Sbjct: 606  HCRKKC----NCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHT 661

Query: 1081 MDVDECQDPAACRPG----RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRD 1136
               D+     +C+ G    RC       + EC   +      + C  P   A        
Sbjct: 662  QSCDKRDGSCSCKAGFRGERC-------QAECELGYFGPGCWQACTCPVGVA-------- 706

Query: 1137 VCWSQRGEDG-MCAGPLAG-------PALTFDDCC---CRQG----RGWGAQCRPCPPRG 1181
             C S  GE G  C     G       P  TF   C   C  G     G   QCR CPP  
Sbjct: 707  -CDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCR-CPPGR 764

Query: 1182 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPG--GAVCE- 1238
             G  C     E    W       G   ++   + + +  C   +G C+  PG  G+ C+ 
Sbjct: 765  TGEDCEADCPEGR--W-------GLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQD 815

Query: 1239 -CPGGFQLDASRARC 1252
             CP G+   + + RC
Sbjct: 816  VCPAGWYGPSCQTRC 830



 Score =  120 bits (302), Expect = 7e-27
 Identities = 166/619 (26%), Positives = 216/619 (34%), Gaps = 133/619 (21%)

Query: 770  CAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQ-CQCLSGYHLSRDRSHCE-DI 827
            C +G+   PD   CL   EC A      G C   PGS Q C C  G+   R    C+ D+
Sbjct: 110  CCRGWMQQPDEEGCLSA-ECSASLCFHGGRC--VPGSAQPCHCPPGFQGPR----CQYDV 162

Query: 828  DECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNL 886
            DEC          C+NT GSY C C  G RL    R C  I+ C+     C  H  C  L
Sbjct: 163  DECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHH--CVQL 220

Query: 887  Q-GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
                + C C  GF   +D   C       ++    ++      C  V         C C 
Sbjct: 221  TITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMH-----RCQVVRGL----ARCECH 271

Query: 946  LG---AGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN--NIVNYGIPAHRDIDECMLF 1000
            +G   A  G  CE     V   A   + C  G   TQ +   + + G     D  +C   
Sbjct: 272  VGYQLAADGKACE----DVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRI 327

Query: 1001 GSEI----------CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050
              EI          C  G C +T  G  C C +G+  D +   C+DVD+C D S C   V
Sbjct: 328  EMEIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD-SPCCQQV 385

Query: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRP 1110
            C N  GGY C C      S     C      DVDEC          C NL GS++C C  
Sbjct: 386  CTNNPGGYECGCYAGYRLSADGCGC-----EDVDECASSRGGCEHHCTNLAGSFQCSCEA 440

Query: 1111 PWVPGPSGRDCQLPESP--------------------AERAP---ERRDVCWSQ-----R 1142
             +      R C   E P                     +  P   +  DV   +     R
Sbjct: 441  GYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELR 500

Query: 1143 GEDGM-----CAGPLAGP--ALTFDDC-----C------CRQGRGW-GAQC-RPCPPRGA 1182
            GE  +     C     G   +LT DDC     C      C    GW G  C   CPP   
Sbjct: 501  GEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTF 560

Query: 1183 GSHCPTSQS-ESNSFWDTSPLLLGKPPRDEDSSEEDS-----------DECRCVS-GRCV 1229
            G +C  S S ++    D+       PP    ++ ED             +C C + GRC 
Sbjct: 561  GKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCH 620

Query: 1230 PRPGGAVCE-----------CPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1278
               G  +C+           CP      A    C +  +C + +       ++ C    G
Sbjct: 621  RLYGACLCDPGLYGRFCHLTCPPW----AFGPGCSEECQCVQPH-------TQSCDKRDG 669

Query: 1279 SFRCVCKAGFARSRPHGAC 1297
            S  C CKAGF   R    C
Sbjct: 670  S--CSCKAGFRGERCQAEC 686



 Score =  110 bits (276), Expect = 7e-24
 Identities = 179/703 (25%), Positives = 230/703 (32%), Gaps = 187/703 (26%)

Query: 586  GHGECVPGPPDYSCH--CNPGYR----SHPQHRYCVDVNECEAEPCGPGRGICMNTGGSY 639
            GH  C PG   +SC   C+ G+     SHP +             C  G G C    G  
Sbjct: 843  GHCSCAPGWTGFSCQRACDTGHWGPDCSHPCN-------------CSAGHGSCDAISGL- 888

Query: 640  NCHCNRGY----------RLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
             C C  GY          + H G G         C +   C  G  C +  G   C C  
Sbjct: 889  -CLCEAGYVGPRCEQQCPQGHFGPG---------CEQRCQCQHGAACDHVSG--ACTCPA 936

Query: 690  GYR---LKASRPPVCEDIDECRDPSSCPDGK-CENKPGSFKCIACQPGYRSQG------- 738
            G+R    + + P     +D CR   +C  G  C+   GS  C A + G R          
Sbjct: 937  GWRGTFCEHACPAGFFGLD-CRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTY 995

Query: 739  GGACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
            G  C     C  G+ C P  G C   PG    +C Q       G +C     C+ G  CD
Sbjct: 996  GHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCD 1055

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDE---CDFPAACI-GGDCINTNGSYRCLC 852
                   P S  C C  G+        C   D    C     C+ GG C    G  RCLC
Sbjct: 1056 -------PVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLC 1106

Query: 853  PQGHRLVGGRKCQDI-------DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQH 905
            P G     G KCQ         + C+Q  S C P  AC ++ G+  C C  GFT +  + 
Sbjct: 1107 PAGWT---GDKCQSPCLRGWFGEACAQRCS-CPPGAACHHVTGA--CRCPPGFTGSGCEQ 1160

Query: 906  GC------EEVEQ----PHHKKECYLNFDDTVFCDSVLATNVTQQEC------------C 943
             C      E+  Q    P     C+     T  C +       QQ C            C
Sbjct: 1161 ACPPGSFGEDCAQMCQCPGENPACH-PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLC 1219

Query: 944  CSLGAGWGDHCE-IYPCPV-YSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001
              L  G  D       CP  +   + +  CP G+      ++   G  A  D     + G
Sbjct: 1220 GCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACD----PVTG 1275

Query: 1002 SEICKEGKCVNTQPGYECY--CKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGY 1058
            + +C  G+      G  C   C Q  +  G          C    +CRNG +C  + G  
Sbjct: 1276 TCLCPPGRA-----GVRCERGCPQNRFGVG----------CEHTCSCRNGGLCHASNGSC 1320

Query: 1059 RC-----------ACTPPAEYSPA-QRQCLSPEEMDVDECQDPAACRP--GRCVNLPGSY 1104
             C           AC PP  Y  A   +C          C + + C P  G C   PG Y
Sbjct: 1321 SCGLGWTGRHCELAC-PPGRYGAACHLEC---------SCHNNSTCEPATGTCRCGPGFY 1370

Query: 1105 RCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE-----DGMCAGPL------- 1152
               C  P  PG  G  CQ              +CW Q G       G C  P        
Sbjct: 1371 GQACEHPCPPGFHGAGCQ-------------GLCWCQHGAPCDPISGRCLCPAGFHGHFC 1417

Query: 1153 ---AGPALTFDDCCCRQGRGWGAQCRP------CPPRGAGSHC 1186
                 P    + C  R     GA C P      CPP  +G+ C
Sbjct: 1418 ERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATC 1460



 Score =  103 bits (257), Expect = 1e-21
 Identities = 84/323 (26%), Positives = 122/323 (37%), Gaps = 46/323 (14%)

Query: 993  DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVC 1051
            D+DEC         + +CVNT   Y C CK GF    +   C+ ++ C L    C++   
Sbjct: 161  DVDECRTHNGGC--QHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCV 218

Query: 1052 ENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVN----LPGSYRCE 1107
            + T   +RC C P  +     R C+          + P A R G C++    + G  RCE
Sbjct: 219  QLTITRHRCQCRPGFQLQEDGRHCVR---------RSPCANRNGSCMHRCQVVRGLARCE 269

Query: 1108 CRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG 1167
            C   +     G+ C+  +  A    +    C + +G                  C C  G
Sbjct: 270  CHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSF---------------KCVCHAG 314

Query: 1168 RGWGAQCRPCP--PRGAGSHCPTSQ---SESNSFWDTSPLLLGKPPRDEDSSEE---DSD 1219
               GA  R C        + C  +    S   S     PL       + D+ +    D D
Sbjct: 315  YELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVD 374

Query: 1220 ECR---CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNT 1276
            +C    C    C   PGG  C C  G++L A    C D+DEC   + RG       C N 
Sbjct: 375  DCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDEC--ASSRGGC--EHHCTNL 430

Query: 1277 SGSFRCVCKAGFARSRPHGACVP 1299
            +GSF+C C+AG+        C P
Sbjct: 431  AGSFQCSCEAGYRLHEDRRGCSP 453



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 191/819 (23%), Positives = 265/819 (32%), Gaps = 157/819 (19%)

Query: 583  NICGHGECVPGPPDYSCH--CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640
            ++ G   C PG    +C   C  GY      + C   N      C    G C+   G Y 
Sbjct: 578  SVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGR---CHRLYGACLCDPGLYG 634

Query: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
              C+        A G  C +  +C +PH       C    G   C+C  G+R +  +   
Sbjct: 635  RFCH--LTCPPWAFGPGCSEECQCVQPHTQS----CDKRDG--SCSCKAGFRGERCQAE- 685

Query: 701  CE---DIDECRDPSSCPDG-KCENKPGSFKC-IACQPGYRSQGGGACRDVN----ECAEG 751
            CE       C    +CP G  C++  G  +C   C  G++ +  G    V      C+  
Sbjct: 686  CELGYFGPGCWQACTCPVGVACDSVSG--ECGKRCPAGFQGEDCGQECPVGTFGVNCSSS 743

Query: 752  SPCSPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDE----CEAGDVCDNGICSNT 803
              C    C  + G  RC    T     A  P+GR  L   E    C+    CD       
Sbjct: 744  CSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCD------- 796

Query: 804  PGSFQCQCLSGYHLSRDRSHCEDI-------DECDFPAACIG-GDCINTNGSYRCLCPQG 855
            P +  C CL G+  SR    C+D+         C    +C   G C    G   C C  G
Sbjct: 797  PETGACLCLPGFVGSR----CQDVCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCAPG 850

Query: 856  HRLVGGRKCQDID----ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
                  ++  D      +CS   +    HG+C  + G  +C+C+ G+   + +  C    
Sbjct: 851  WTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQQCP--- 905

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW-GDHCEIYPCPV-YSSAEFHS 969
            Q H    C    +    C    A +     C C   AGW G  CE + CP  +   +  S
Sbjct: 906  QGHFGPGC----EQRCQCQHGAACDHVSGACTCP--AGWRGTFCE-HACPAGFFGLDCRS 958

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECM------LFGSEICKEGKCVN---TQPGY-EC 1019
             C    G   D    +   PA R    C        +G    +   C N     P + +C
Sbjct: 959  ACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQC 1018

Query: 1020 YCKQGFYYDGNLLEC---VDVDECLDESNCRNG-VCENTRGGYRC--------------- 1060
            +C  G+     L  C   +  D C     C+NG  C+   G   C               
Sbjct: 1019 HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLP 1078

Query: 1061 -----------ACTPPAEYSPAQRQCLSPEEMDVDECQDPA-------------ACRPGR 1096
                        C       P   +CL P     D+CQ P              +C PG 
Sbjct: 1079 RDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGA 1138

Query: 1097 -CVNLPGSYRCE-------CRPPWVPGPSGRDC-QLPESPAERAPERRDVCWSQRGEDGM 1147
             C ++ G+ RC        C     PG  G DC Q+ + P E        C    G    
Sbjct: 1139 ACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENP-----ACHPATGTCS- 1192

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCR-----PCPPRGAGSHCPTSQSESNSFWDTSPL 1202
            CA    GP+        R G G    C       C        CPT    ++    T P 
Sbjct: 1193 CAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL-TCPQ 1251

Query: 1203 LLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELN 1262
                P             C  V+G C+  PG A   C  G   +     C     CR   
Sbjct: 1252 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCR--- 1308

Query: 1263 QRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301
              G LC +     ++GS  C C  G+       AC P R
Sbjct: 1309 -NGGLCHA-----SNGS--CSCGLGWTGRHCELACPPGR 1339



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 92/339 (27%), Positives = 112/339 (33%), Gaps = 60/339 (17%)

Query: 594  PPDYSCHCNPGYRSH------PQHRY---CVDVNEC-EAEPCGPGRGICMNTGGSYNCHC 643
            P   +C C  GY         P  RY   C  +  C     C    G C    G     C
Sbjct: 1186 PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC 1245

Query: 644  NRGYRLHVGAGGRSCVDLNECAKPHLCGD-GGFCINFPGHYKCNCYPGYRLKASRPPV-C 701
            N       G  G +C  +  C +   C    G C+  PG     C  G     +R  V C
Sbjct: 1246 N--LTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG--CPQNRFGVGC 1301

Query: 702  EDIDECRDPSSCPDGKCENKPGSFKC----------IACQPGYRSQGGGACRDVNECAEG 751
            E    CR+      G C    GS  C          +AC PG   + G AC     C   
Sbjct: 1302 EHTCSCRN-----GGLCHASNGSCSCGLGWTGRHCELACPPG---RYGAACHLECSCHNN 1353

Query: 752  SPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQC 809
            S C P  G C   PG +   C     P   G  C  +  C+ G  CD       P S +C
Sbjct: 1354 STCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCD-------PISGRC 1406

Query: 810  QCLSGYHLSRDRSHCED---IDECDFPAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQ 865
             C +G+H       CE     + C     C GG  C    G   CLCP G     G  C 
Sbjct: 1407 LCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTG--LCLCPPGR---SGATCN 1461

Query: 866  DIDECSQDPSLCLPH-----GA-CKNLQGSYVCVCDEGF 898
                  Q    C  H     GA C  + G   C C +G+
Sbjct: 1462 LDCRRGQFGPSCTLHCDCGGGADCDPVSGQ--CHCVDGY 1498



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 49/161 (30%), Positives = 65/161 (40%), Gaps = 23/161 (14%)

Query: 279 CFQDTLPKQPCGSNPLPGLTKQED---CCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVR 334
           C Q T+ +  C   P  G   QED   C      A     C H+C             VR
Sbjct: 217 CVQLTITRHRCQCRP--GFQLQEDGRHCVRRSPCANRNGSCMHRCQV-----------VR 263

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
           G    +C  GY+   +   C+D++ECA     C HG CLN  GS++CVC  G+ LG    
Sbjct: 264 GLARCECHVGYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGR 322

Query: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           QC   + E  + C    +    C H  +      LC C  G
Sbjct: 323 QCYRIEMEIVNSC---EANNGGCSHGCSHTSAGPLCTCPRG 360



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 33/74 (44%), Positives = 37/74 (50%), Gaps = 10/74 (13%)

Query: 1226 GRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCKSERCVNTSGSFRCVC 1284
            GRCVP      C CP GFQ      RC  D+DECR  N     C+  RCVNT GS+ C C
Sbjct: 137  GRCVPG-SAQPCHCPPGFQ----GPRCQYDVDECRTHNGG---CQ-HRCVNTPGSYLCEC 187

Query: 1285 KAGFARSRPHGACV 1298
            K GF        C+
Sbjct: 188  KPGFRLHTDSRTCL 201



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 29/94 (30%), Positives = 39/94 (41%), Gaps = 10/94 (10%)

Query: 341 CPQGYKR-LNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
           CP+GY+   +   C D+++CA    C+   C NNPG Y C C  G+ L      C     
Sbjct: 357 CPRGYELDTDQRTCIDVDDCADSPCCQQV-CTNNPGGYECGCYAGYRLSADGCGC----- 410

Query: 400 EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           E+   C    S    C+H  T       C C  G
Sbjct: 411 EDVDEC---ASSRGGCEHHCTNLAGSFQCSCEAG 441



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 32/95 (33%), Positives = 42/95 (44%), Gaps = 13/95 (13%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           CP G++      CQ D++EC    G C+H  C+N PGSY C C PG  L      C+A  
Sbjct: 149 CPPGFQ---GPRCQYDVDECRTHNGGCQHR-CVNTPGSYLCECKPGFRLHTDSRTCLA-- 202

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
               S        +H C   +   +TR  C C  G
Sbjct: 203 --INSCALGNGGCQHHC---VQLTITRHRCQCRPG 232



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 7/81 (8%)

Query: 316 CHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQDINECAMP-GVCRHGDCLNN 373
           C   P  Q      PG         C  GY+   +   C+D++ECA   G C H  C N 
Sbjct: 376 CADSPCCQQVCTNNPGGYE----CGCYAGYRLSADGCGCEDVDECASSRGGCEH-HCTNL 430

Query: 374 PGSYRCVCPPGHSLGPSRTQC 394
            GS++C C  G+ L   R  C
Sbjct: 431 AGSFQCSCEAGYRLHEDRRGC 451



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 25/94 (26%)

Query: 71   CKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG-----SGFRVVVCP---LP------ 116
            C + C  G   D+C+     + + +NG + D ++G      G+  + C    LP      
Sbjct: 1029 CLQACPAGLYGDNCRH----SCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAG 1084

Query: 117  ------CMNGGQCSSRN-QCLCPPDFTGRFCQVP 143
                  C+NGG C     +CLCP  +TG  CQ P
Sbjct: 1085 CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSP 1118



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 29/106 (27%), Positives = 39/106 (36%), Gaps = 27/106 (25%)

Query: 66   FAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG-----SGFRVVVCPLPCMNG 120
            +A + C++ CL    R  C+          NG   D  TG     +G+    C  PC+ G
Sbjct: 1067 WAGLACEKECLPRDVRAGCRHSGGCL----NGGLCDPHTGRCLCPAGWTGDKCQSPCLRG 1122

Query: 121  G---QCSSR-------------NQCLCPPDFTGRFCQ--VPAGGAG 148
                 C+ R               C CPP FTG  C+   P G  G
Sbjct: 1123 WFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFG 1168



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 42/151 (27%), Positives = 59/151 (39%), Gaps = 28/151 (18%)

Query: 332  PVRGEVGADCPQGYKRLNSTHCQDINECAMPGV---CRH-GDCLN----NPGSYRCVCPP 383
            PV G     CP+G+  L    C+   EC    V   CRH G CLN    +P + RC+CP 
Sbjct: 1056 PVSGHCA--CPEGWAGLA---CE--KECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPA 1108

Query: 384  GHSLGPSRTQCI----ADKPEEKSLCFRLVSPEH-----QCQHPLTTRLTRQLC-CCSVG 433
            G +    ++ C+     +   ++  C    +  H     +C    T     Q C   S G
Sbjct: 1109 GWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFG 1168

Query: 434  KAWGARCQRCPTDGTAAFKE--ICPAGKGYH 462
            +     CQ CP +  A       C    GYH
Sbjct: 1169 EDCAQMCQ-CPGENPACHPATGTCSCAAGYH 1198



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 15/39 (38%), Positives = 17/39 (43%), Gaps = 2/39 (5%)

Query: 117 CMNGGQC--SSRNQCLCPPDFTGRFCQVPAGGAGGGTGG 153
           C +GG+C   S   C CPP F G  CQ          GG
Sbjct: 133 CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGG 171



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 29/105 (27%), Positives = 37/105 (35%), Gaps = 26/105 (24%)

Query: 71   CKRTCLKGQ----CRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG------ 120
            C+  C  G+    C   C   +N T     G       G GF    C  PC  G      
Sbjct: 1331 CELACPPGRYGAACHLECSCHNNSTCEPATGTCR---CGPGFYGQACEHPCPPGFHGAGC 1387

Query: 121  -GQCSSRN---------QCLCPPDFTGRFCQVPAGGAGGGTGGSG 155
             G C  ++         +CLCP  F G FC+    G   G+ G G
Sbjct: 1388 QGLCWCQHGAPCDPISGRCLCPAGFHGHFCE---RGCEPGSFGEG 1429


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  222 bits (566), Expect = 2e-57
 Identities = 230/795 (28%), Positives = 299/795 (37%), Gaps = 177/795 (22%)

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            D+C  + + C HG CV G   +SC C PGY      R    V+EC ++PC  G G C++ 
Sbjct: 547  DDC--SPDPCHHGRCVDGIASFSCACAPGYTGT---RCESQVDECRSQPCRHG-GKCLDL 600

Query: 636  GGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
               Y C C  G        G +C V++++CA  + C   G C +    Y C C PG+   
Sbjct: 601  VDKYLCRCPSG------TTGVNCEVNIDDCAS-NPC-TFGVCRDGINRYDCVCQPGFT-- 650

Query: 695  ASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSP 753
                P+C  +I+EC        G C +    F+C+ C PG        C   +      P
Sbjct: 651  ---GPLCNVEINECASSPCGEGGSCVDGENGFRCL-CPPGSLPP---LCLPPSHPCAHEP 703

Query: 754  CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
            CS G C + PG FRC C  G++  P     L  D CE+      G CS+    F C C  
Sbjct: 704  CSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP 762

Query: 814  GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYR-CLCPQGHRLVGGRKCQDIDECSQ 872
            G         CE +  C       GG C +  G    C CPQG +  G R  QD+DEC+ 
Sbjct: 763  GVQ----GRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ--GPRCQQDVDECA- 815

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFT-PTQDQHGCEEVEQPHHKKECYLNFDDTVFC-- 929
             P+ C PHG C NL GS+ C C  G+T P+ DQ                +N  D   C  
Sbjct: 816  GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQD---------------INDCDPNPCLN 860

Query: 930  DSVLATNVTQQECCCSLG------AGWGDHCEIYPCPVYSS----AEFHSLCPDGKGYTQ 979
                   V    C C  G      A   D C   PC   +     A F   CP G G   
Sbjct: 861  GGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYG--- 917

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039
                   G    +D+ +C    S     G CV+    + C C+ G  Y G   +  + D 
Sbjct: 918  -------GFHCEQDLPDCS--PSSCFNGGTCVDGVNSFSCLCRPG--YTGAHCQH-EADP 965

Query: 1040 CLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVN 1099
            CL       GVC     G+RC C     ++  Q Q L      VD C        GRCV 
Sbjct: 966  CLSRPCLHGGVCSAAHPGFRCTCLE--SFTGPQCQTL------VDWCSRQPCQNGGRCVQ 1017

Query: 1100 LPGSYRCECRPPWVPGPSGRDCQLPESPAERA---------------------------- 1131
              G+Y C C P W    SGR C +   P   A                            
Sbjct: 1018 T-GAY-CLCPPGW----SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV 1071

Query: 1132 -PERR---------DVCWSQRGEDG-MCAGPLAG------PALTFDDC------CCRQGR 1168
             PE R         D C +Q  + G  C G + G      P    D+C      C  Q  
Sbjct: 1072 CPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131

Query: 1169 GWGAQCRP--------CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
              G  C          CPP   G  C  ++       D  P     PP D          
Sbjct: 1132 QHGGSCIDLVARYLCSCPPGTLGVLCEINED------DCGP----GPPLDSGP------- 1174

Query: 1221 CRCV-SGRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCKSERCV-NTS 1277
             RC+ +G CV   GG  C CP G+    +  RC  DI+ECR          +  C+ +  
Sbjct: 1175 -RCLHNGTCVDLVGGFRCTCPPGY----TGLRCEADINECRSGACHA--AHTRDCLQDPG 1227

Query: 1278 GSFRCVCKAGFARSR 1292
            G FRC+C AGF+  R
Sbjct: 1228 GGFRCLCHAGFSGPR 1242



 Score =  220 bits (561), Expect = 6e-57
 Identities = 264/1015 (26%), Positives = 371/1015 (36%), Gaps = 222/1015 (21%)

Query: 338  GADC---PQGYK-----RLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388
            GA C   P GY+         T C +++++C+ P  C HG C++   S+ C C PG+   
Sbjct: 519  GAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS-PDPCHHGRCVDGIASFSCACAPGY--- 574

Query: 389  PSRTQCIADKPEEKSLCFRLVSPEHQCQH--PLTTRLTRQLCCCSVGKAWGARCQ----R 442
             + T+C +   E +S           C+H       + + LC C  G   G  C+     
Sbjct: 575  -TGTRCESQVDECRS---------QPCRHGGKCLDLVDKYLCRCPSGTT-GVNCEVNIDD 623

Query: 443  CPT---------DGTAAFKEICPAGKGYHILT-----------SHQTLTIQGESDFSLFL 482
            C +         DG   +  +C  G    +                   + GE+ F   L
Sbjct: 624  CASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC-L 682

Query: 483  HPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             P G   P  LP S   A  P       G+  D+P                         
Sbjct: 683  CPPGSLPPLCLPPSHPCAHEP----CSHGICYDAPGGF--------------------RC 718

Query: 543  ISRPSPPTMRWFLPDLPPS--RSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            +  P      W  P    S  R A E  P        CR        G C      + C 
Sbjct: 719  VCEPG-----WSGPRCSQSLARDACESQP--------CRAG------GTCSSDGMGFHCT 759

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN-CHCNRGYRLHVGAGGRSCV 659
            C PG     Q R C  ++ C   PC  G G C +  G    C C +G++     G R   
Sbjct: 760  CPPGV----QGRQCELLSPCTPNPCEHG-GRCESAPGQLPVCSCPQGWQ-----GPRCQQ 809

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPD-GKC 718
            D++ECA P  CG  G C N  G + C C+ GY    + P   +DI++C DP+ C + G C
Sbjct: 810  DVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDC-DPNPCLNGGSC 864

Query: 719  ENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778
            ++  GSF C +C PG+   G    RDV+EC   +PC PG C +   SF CTC  GY    
Sbjct: 865  QDGVGSFSC-SCLPGF--AGPRCARDVDECL-SNPCGPGTCTDHVASFTCTCPPGYG--- 917

Query: 779  DGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFPAAC 836
             G  C  D+ +C      + G C +   SF C C  GY      +HC+ + D C      
Sbjct: 918  -GFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHCQHEADPCLSRPCL 972

Query: 837  IGGDCINTNGSYRCLCPQGHRLVGGRKCQD-IDECSQDPSLCLPHGACKNLQGSYVCVCD 895
             GG C   +  +RC C +      G +CQ  +D CS+ P  C   G C  +Q    C+C 
Sbjct: 973  HGGVCSAAHPGFRCTCLESFT---GPQCQTLVDWCSRQP--CQNGGRC--VQTGAYCLCP 1025

Query: 896  EGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
             G++                             CD     ++  +E    +G      C+
Sbjct: 1026 PGWSGR--------------------------LCD---IRSLPCREAAAQIGVRLEQLCQ 1056

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQ 1014
                 V   +  + +CP+G+           G    +++D C+   ++ C+  G C    
Sbjct: 1057 AGGQCVDEDSSHYCVCPEGR----------TGSHCEQEVDPCL---AQPCQHGGTCRGYM 1103

Query: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
             GY C C  G  Y+G+  E  DVDEC  +     G C +    Y C+C PP         
Sbjct: 1104 GGYMCECLPG--YNGDNCE-DDVDECASQPCQHGGSCIDLVARYLCSC-PPGTLGVL--- 1156

Query: 1075 CLSPEEMDVDEC-------QDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESP 1127
            C    E++ D+C         P     G CV+L G +RC C P +       D     S 
Sbjct: 1157 C----EINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSG 1212

Query: 1128 AERAPERRDVCWSQRGE-DGMCAGPLAGP-ALTFDDCCCRQGRGWGAQCRPCPPRGAG-- 1183
            A  A   RD      G    +C    +GP   T    C  Q    G QCRP P  G G  
Sbjct: 1213 ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLT 1272

Query: 1184 --SHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG-RCVPRPGGAVCECP 1240
               HC      +  FW          PR E  +     E +C  G  C   P G  C CP
Sbjct: 1273 FTCHC------AQPFWG---------PRCERVA-RSCRELQCPVGVPCQQTPRGPRCACP 1316

Query: 1241 GGFQLDASRARCVDIDECRELNQRGLLC---KSERCVNTSGSFRCVCKAGFARSR 1292
             G    + R+           +     C    S R    +  FRC C  G+   R
Sbjct: 1317 PGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371



 Score =  216 bits (549), Expect = 1e-55
 Identities = 229/860 (26%), Positives = 320/860 (37%), Gaps = 208/860 (24%)

Query: 560  PSRSAVEIAPTQVTETDECRLNQNICGHGEC----------VPGPPDYSCHCNPGYRSHP 609
            PSR A  + P      + C+L ++ C  G C          V G   +SC C  G+R   
Sbjct: 59   PSREAACLCPPGWVG-ERCQL-EDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPD 116

Query: 610  QHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPH 668
                C   + C + PC  G    +   G + C C  GY+      GRSC  D++EC    
Sbjct: 117  ----CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ------GRSCRSDVDECRVGE 166

Query: 669  LCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG--SFK 726
             C  GG C+N PG ++C C  GY       P+CE+      PS C +G    + G  ++ 
Sbjct: 167  PCRHGGTCLNTPGSFRCQCPAGYT-----GPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221

Query: 727  CIACQPGYRSQGGGACR-DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL- 784
            C AC PG+  Q    C  +V++C      + G C +   ++ C C     P   G+ C  
Sbjct: 222  C-ACLPGFEGQN---CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP----PEWTGQFCTE 273

Query: 785  DVDECEAG-DVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI 842
            DVDEC+   + C NG  C NT G   C C++G+      S  ++ID+C       G  C 
Sbjct: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW---TGESCSQNIDDCATAVCFHGATCH 330

Query: 843  NTNGSYRCLCPQGHR-------------------------------------LVGGRKCQ 865
            +   S+ C CP G                                         GG   Q
Sbjct: 331  DRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT-PTQDQHGCEEVEQPHHKKECYLNFD 924
            D+DECS   + C   G C N QGS++C C  G+T P  +    E +  P   +   L+  
Sbjct: 391  DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450

Query: 925  DTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE-----FHSLCPDGKGYTQ 979
                C  +     T   C   +     D C+  PC      +     F   CP G     
Sbjct: 451  GQFTC--ICMAGFTGTYCEVDI-----DECQSSPCVNGGVCKDRVNGFSCTCPSGFS--- 500

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVD 1038
                   G     D+DEC    S  C+ G KCV+   GYEC C +GF  +G L +  +VD
Sbjct: 501  -------GSTCQLDVDEC---ASTPCRNGAKCVDQPDGYECRCAEGF--EGTLCD-RNVD 547

Query: 1039 ECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCV 1098
            +C  +  C +G C +    + CAC P         +C    E  VDEC+       G+C+
Sbjct: 548  DCSPDP-CHHGRCVDGIASFSCACAP----GYTGTRC----ESQVDECRSQPCRHGGKCL 598

Query: 1099 NLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE-DGMCAGPLAGPA- 1156
            +L   Y C C      G +G +C++        P    VC       D +C     GP  
Sbjct: 599  DLVDKYLCRC----PSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLC 654

Query: 1157 -LTFDDCC---CRQG-------RGWGAQCRP----------------------------- 1176
             +  ++C    C +G        G+   C P                             
Sbjct: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPG 714

Query: 1177 -----CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC---VSGR- 1227
                 C P  +G  C  SQS +    ++ P   G       SS+     C C   V GR 
Sbjct: 715  GFRCVCEPGWSGPRC--SQSLARDACESQPCRAG----GTCSSDGMGFHCTCPPGVQGRQ 768

Query: 1228 ------CVPRP---GG---------AVCECPGGFQLDASRARC-VDIDECRELNQRGLLC 1268
                  C P P   GG          VC CP G+Q      RC  D+DEC      G   
Sbjct: 769  CELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECAGPAPCG--- 821

Query: 1269 KSERCVNTSGSFRCVCKAGF 1288
                C N +GSF C C  G+
Sbjct: 822  PHGICTNLAGSFSCTCHGGY 841



 Score =  176 bits (447), Expect = 1e-43
 Identities = 237/958 (24%), Positives = 323/958 (33%), Gaps = 214/958 (22%)

Query: 355  DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414
            +INECA       G C++    +RC+CPPG SL P              LC   + P H 
Sbjct: 657  EINECASSPCGEGGSCVDGENGFRCLCPPG-SLPP--------------LC---LPPSHP 698

Query: 415  CQH-PLTTRLTRQL-----CCCSVGKAWGARCQR------CPTDGTAAFKEICPAGKGYH 462
            C H P +  +         C C  G + G RC +      C +    A       G G+H
Sbjct: 699  CAHEPCSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARDACESQPCRAGGTCSSDGMGFH 757

Query: 463  ILTSHQTLTIQGESDFSLFLHPDGPPKPQ---QLPESPSQAPPPEDTEEERGVTTDSPVS 519
                      Q E      L P  P   +   +   +P Q P     +  +G      V 
Sbjct: 758  CTCPPGVQGRQCE-----LLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD 812

Query: 520  EERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAV----EIAPTQVTET 575
            E                       + P+P        +L  S S         P+   + 
Sbjct: 813  E----------------------CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            ++C  N  + G G C  G   +SC C PG+      R   DV+EC + PCGP  G C + 
Sbjct: 851  NDCDPNPCLNG-GSCQDGVGSFSCSCLPGFAG---PRCARDVDECLSNPCGP--GTCTDH 904

Query: 636  GGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
              S+ C C  GY      GG  C  DL +C+ P  C +GG C++    + C C PGY   
Sbjct: 905  VASFTCTCPPGY------GGFHCEQDLPDCS-PSSCFNGGTCVDGVNSFSCLCRPGY--- 954

Query: 695  ASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA--------CQPGYRSQGGGACRDVN 746
             +      + D C        G C      F+C          CQ          C++  
Sbjct: 955  -TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGG 1013

Query: 747  ECAEGSP---CSPGWCENLPGSFRCTCAQG-------------------------YAPAP 778
             C +      C PGW   L       C +                          Y   P
Sbjct: 1014 RCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCP 1073

Query: 779  DGRS---C-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFP 833
            +GR+   C  +VD C A      G C    G + C+CL GY    +  +CE D+DEC   
Sbjct: 1074 EGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQ 1129

Query: 834  AACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSL-----CLPHGACKNLQ 887
                GG CI+    Y C CP G     G  C+ + D+C   P L     CL +G C +L 
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPG---TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV 1186

Query: 888  GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG 947
            G + C C  G+T  +    CE                D   C S        ++C    G
Sbjct: 1187 GGFRCTCPPGYTGLR----CEA---------------DINECRSGACHAAHTRDCLQDPG 1227

Query: 948  AGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE 1007
             G                 F  LC  G    +   +++   P            S+ C+ 
Sbjct: 1228 GG-----------------FRCLCHAGFSGPRCQTVLS---PCE----------SQPCQH 1257

Query: 1008 GKCVNTQPG------YECYCKQGFYYDGNLLECVDVDECLDESNCRNGV-CENTRGGYRC 1060
            G      PG      + C+C Q F+       C  V     E  C  GV C+ T  G RC
Sbjct: 1258 GGQCRPSPGPGGGLTFTCHCAQPFWGP----RCERVARSCRELQCPVGVPCQQTPRGPRC 1313

Query: 1061 ACTPPAEYSPAQRQCL-SPEEMDVDECQDPAACRPGRCVNLPGS--YRCECRPPWVPGPS 1117
            AC PP    P+ R    SP       C        G C   P +  +RC C   W    +
Sbjct: 1314 AC-PPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGW----T 1368

Query: 1118 GRDCQLPESPAERAPE---RRDVCWSQRGEDGMCAGPLAGPALTFD--DCCCRQGRGWGA 1172
            G  C+ P +  E + E    R  C ++RG D  C      P   +D  DC    G  W  
Sbjct: 1369 GPRCEAPAAAPEVSEEPRCPRAACQAKRG-DQRCDRECNSPGCGWDGGDCSLSVGDPW-R 1426

Query: 1173 QCR--PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1228
            QC    C      S C  + S     +D      G   R  +   E         GRC
Sbjct: 1427 QCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRC 1484



 Score =  135 bits (341), Expect = 2e-31
 Identities = 149/608 (24%), Positives = 210/608 (34%), Gaps = 135/608 (22%)

Query: 748  CAEGSPCSPGW-CENLPG-SFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNT-- 803
            C +GSPC+ G  C  LP     C C  G+     G  C   D C +G     G+C ++  
Sbjct: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWV----GERCQLEDPCHSGPCAGRGVCQSSVV 98

Query: 804  --PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDC-------INTNGSYRCLCPQ 854
                 F C+C  G+             +C  P  C+   C       +  +G + C CP 
Sbjct: 99   AGTARFSCRCPRGFRGP----------DCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPP 148

Query: 855  GHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQP 913
            G++   GR C+ D+DEC      C   G C N  GS+ C C  G+T       CE    P
Sbjct: 149  GYQ---GRSCRSDVDECRVGEP-CRHGGTCLNTPGSFRCQCPAGYTGPL----CENPAVP 200

Query: 914  HHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY--PCPVYSSAEFHSLC 971
                 C           +   +     +C C  G   G +CE+    CP +        C
Sbjct: 201  CAPSPCRNG-------GTCRQSGDLTYDCACLPGFE-GQNCEVNVDDCPGHR-------C 245

Query: 972  PDGKGYTQDNNIVNYGIPAH-------RDIDECMLFGSEICKEGKCVNTQPGYECYCKQG 1024
             +G       N  N   P          D+DEC L  +     G C NT  G+ C C  G
Sbjct: 246  LNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305

Query: 1025 FYYDG---NLLECVDV-------------------------------DECLDESNCRNGV 1050
            +  +    N+ +C                                  D C+      + +
Sbjct: 306  WTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAI 365

Query: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA-ACRP-GRCVNLPGSYRCEC 1108
            C+      R  CT P  ++     C    + DVDEC   A  C   GRCVN  GS+ C+C
Sbjct: 366  CDTNPVNGRAICTCPPGFTGGA--C----DQDVDECSIGANPCEHLGRCVNTQGSFLCQC 419

Query: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDV-CWSQRGE-DGMCAGPLAGP--ALTFDDCCC 1164
                  G +G  C+   +     P R    C  + G+   +C     G    +  D+C  
Sbjct: 420  GR----GYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC-- 473

Query: 1165 RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCV 1224
                    Q  PC   G        +   N F  T P          D  E  S  CR  
Sbjct: 474  --------QSSPCVNGGV------CKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRN- 518

Query: 1225 SGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVC 1284
              +CV +P G  C C  GF+         ++D+C         C   RCV+   SF C C
Sbjct: 519  GAKCVDQPDGYECRCAEGFEGTLCDR---NVDDCSPDP-----CHHGRCVDGIASFSCAC 570

Query: 1285 KAGFARSR 1292
              G+  +R
Sbjct: 571  APGYTGTR 578



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 64/219 (29%), Positives = 75/219 (34%), Gaps = 66/219 (30%)

Query: 1086 CQDPAAC-RPGRCVNLPG-SYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG 1143
            C D + C   GRC  LP     C C P WV    G  CQL                    
Sbjct: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWV----GERCQL-------------------- 78

Query: 1144 EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1203
            ED   +GP AG  +          R     CR CP    G  C                 
Sbjct: 79   EDPCHSGPCAGRGVCQSSVVAGTAR---FSCR-CPRGFRGPDCSLPDP-----------C 123

Query: 1204 LGKPPRDEDSSEEDSDECRCVSG-RCVPRPGGA-VCECPGGFQLDASRARCVDIDECREL 1261
            L  P               C  G RC   P G  +C CP G+Q  + R+   D+DECR  
Sbjct: 124  LSSP---------------CAHGARCSVGPDGRFLCSCPPGYQGRSCRS---DVDECRV- 164

Query: 1262 NQRGLLCK-SERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
               G  C+    C+NT GSFRC C AG+         VP
Sbjct: 165  ---GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 40/121 (33%), Positives = 55/121 (45%), Gaps = 24/121 (19%)

Query: 286 KQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQ-LQYTGVQKPGP---------VRG 335
           + PC S P  G   +  C  S+     +  C +CP+  +      P P          R 
Sbjct: 79  EDPCHSGPCAG---RGVCQSSVVAGTARFSC-RCPRGFRGPDCSLPDPCLSSPCAHGARC 134

Query: 336 EVGAD------CPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCPPGHSLG 388
            VG D      CP GY+  +     D++EC +   CRHG  CLN PGS+RC CP G++ G
Sbjct: 135 SVGPDGRFLCSCPPGYQGRSCR--SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT-G 191

Query: 389 P 389
           P
Sbjct: 192 P 192



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/354 (24%), Positives = 111/354 (31%), Gaps = 92/354 (25%)

Query: 116 PCMNGGQC----SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPP 171
           PC NGG+C    S    CLCPP + G  CQ+      G   G G   S   A  T     
Sbjct: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVA-GTARFSC 106

Query: 172 LAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGP-GQISAEVQAPPPVVNV 230
             P G                  P P    P  H A    +GP G+              
Sbjct: 107 RCPRGFRGPD----------CSLPDPCLSSPCAHGA-RCSVGPDGRFLCSC--------- 146

Query: 231 RVHHPPEASVQVHRIESSNAESAAPSQH---LLPHPKPSHPRPPTQKPLGRCFQDTLPKQ 287
               PP    +  R +        P +H    L  P     + P       C     P  
Sbjct: 147 ----PPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN---PAV 199

Query: 288 PCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPG--PVRGEVGADCPQGY 345
           PC  +P          C + GT      C +   L Y     PG      EV  D   G+
Sbjct: 200 PCAPSP----------CRNGGT------CRQSGDLTYDCACLPGFEGQNCEVNVDDCPGH 243

Query: 346 KRLNSTHC---------------------QDINECAM-PGVCRH-GDCLNNPGSYRCVCP 382
           + LN   C                     +D++EC + P  C + G C N  G + CVC 
Sbjct: 244 RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCV 303

Query: 383 PGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT--TRLTRQLCCCSVGK 434
            G + G S +Q I D       C   V     C H  T   R+    C C +GK
Sbjct: 304 NGWT-GESCSQNIDD-------CATAV-----CFHGATCHDRVASFYCACPMGK 344



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/148 (26%), Positives = 53/148 (35%), Gaps = 21/148 (14%)

Query: 328  QKPGPVRGEVGA---DCPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPP 383
            Q  G  RG +G    +C  GY   N  +C+D ++ECA       G C++    Y C CPP
Sbjct: 1094 QHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPP 1150

Query: 384  G----------HSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHP---LTTRLTRQLCCC 430
            G             GP        +      C  LV    +C  P      R    +  C
Sbjct: 1151 GTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRCEADINEC 1209

Query: 431  SVGKAWGARCQRCPTDGTAAFKEICPAG 458
              G    A  + C  D    F+ +C AG
Sbjct: 1210 RSGACHAAHTRDCLQDPGGGFRCLCHAG 1237



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 11/74 (14%)

Query: 73   RTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVV---CPLPCMNGGQCSSRNQ- 128
            R CL G    +   G   T +       ++ TG   + +V      PC NGG+C      
Sbjct: 969  RPCLHGGVCSAAHPGFRCTCL-------ESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021

Query: 129  CLCPPDFTGRFCQV 142
            CLCPP ++GR C +
Sbjct: 1022 CLCPPGWSGRLCDI 1035



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 17/77 (22%)

Query: 75  CLKGQCRD--SCQQGSNMT-----LIGENGHSTDTLTGSGFRVVVCP-LPCMNGGQCS-- 124
           C    CR+  +C+Q  ++T     L G  G + +        V  CP   C+NGG C   
Sbjct: 201 CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV------NVDDCPGHRCLNGGTCVDG 254

Query: 125 -SRNQCLCPPDFTGRFC 140
            +   C CPP++TG+FC
Sbjct: 255 VNTYNCQCPPEWTGQFC 271



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 18/79 (22%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQCSSR 126
           CL G CR+        T +   G  T  +  +GF    C +        PC+NGG C  R
Sbjct: 435 CLSGPCRNQA------TCLDRIGQFT-CICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR 487

Query: 127 ---NQCLCPPDFTGRFCQV 142
                C CP  F+G  CQ+
Sbjct: 488 VNGFSCTCPSGFSGSTCQL 506



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 53/186 (28%), Positives = 66/186 (35%), Gaps = 48/186 (25%)

Query: 28  LLLLLLLLGLGGRVEGGPAGERGAGGGGAL---ARERFKVVFAPVICKRTCLKGQCR--D 82
           L LLLLL G G        G   A GG      +RE      A  +C    +  +C+  D
Sbjct: 27  LPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSRE------AACLCPPGWVGERCQLED 80

Query: 83  SCQQGSNMTLIGENGHSTDTLTGS---------GFRVVVCPLP-------CMNGGQCS-- 124
            C  G      G     +  + G+         GFR   C LP       C +G +CS  
Sbjct: 81  PCHSGP---CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVG 137

Query: 125 --SRNQCLCPPDFTGRF-------CQVPAGGAGGGTGGSGPGLSR-------TGALSTGA 168
              R  C CPP + GR        C+V      GGT  + PG  R       TG L    
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197

Query: 169 LPPLAP 174
             P AP
Sbjct: 198 AVPCAP 203



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 33/106 (31%), Positives = 44/106 (41%), Gaps = 25/106 (23%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
           CP G+    ST   D++ECA    CR+G  C++ P  Y C C  G               
Sbjct: 495 CPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGF-------------- 537

Query: 400 EEKSLCFRLV---SPEHQCQH-PLTTRLTRQLCCCSVGKAWGARCQ 441
            E +LC R V   SP+  C H      +    C C+ G   G RC+
Sbjct: 538 -EGTLCDRNVDDCSPD-PCHHGRCVDGIASFSCACAPGYT-GTRCE 580



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 75/299 (25%), Positives = 90/299 (30%), Gaps = 70/299 (23%)

Query: 125 SRNQCLCPPDFTGRFCQV--------PAGGAGGGTGGSGPG--LSRTGALSTGALPPLAP 174
           +R  C+C P FTG  C V        P G  G    G      L   G+L    LPP  P
Sbjct: 639 NRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHP 698

Query: 175 EGDSVASKHAIYAVQVIADPPG-------PG-EGPPAQHAAFLVPLGPGQISAEVQAPPP 226
                 S    Y      D PG       PG  GP    +            A       
Sbjct: 699 CAHEPCSHGICY------DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD 752

Query: 227 VVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLG----RCFQD 282
            +      PP   VQ  + E  +  +  P +H           P    P G    RC QD
Sbjct: 753 GMGFHCTCPP--GVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD 810

Query: 283 TLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP 342
                 C + P P        CG  G          C  L            G     C 
Sbjct: 811 V---DEC-AGPAP--------CGPHGI---------CTNLA-----------GSFSCTCH 838

Query: 343 QGYKRLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
            GY       C QDIN+C        G C +  GS+ C C PG + GP   +C  D  E
Sbjct: 839 GGY---TGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA-GP---RCARDVDE 890



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 29/91 (31%), Positives = 34/91 (37%), Gaps = 11/91 (12%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQ---CLC 131
           C  G C D+         + E G S    + S  R      PC  GG CSS      C C
Sbjct: 704 CSHGICYDA---PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC 760

Query: 132 PPDFTGRFCQV-----PAGGAGGGTGGSGPG 157
           PP   GR C++     P     GG   S PG
Sbjct: 761 PPGVQGRQCELLSPCTPNPCEHGGRCESAPG 791



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 37/130 (28%), Positives = 48/130 (36%), Gaps = 28/130 (21%)

Query: 149  GGTGGSGPGLSRTGA--LSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHA 206
            GG G +G G    G   LS G L P+A   D        +A      PPGP         
Sbjct: 2141 GGPGRAGLGRQPPGGCVLSLGLLNPVAVPLD--------WARLPPPAPPGP--------- 2183

Query: 207  AFLVPLGPGQ--------ISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQH 258
            +FL+PL PG         +S + + PPP + V  H     +   H           PS+H
Sbjct: 2184 SFLLPLAPGPQLLNPGTPVSPQ-ERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEH 2242

Query: 259  LLPHPKPSHP 268
                P P  P
Sbjct: 2243 PYLTPSPESP 2252



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 10/72 (13%)

Query: 334 RGEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRH-GDCLNNPGSYRCVCPPGHSLGPSR 391
           +G     C +GY       C+ D+NEC + G CR+   CL+  G + C+C  G     + 
Sbjct: 412 QGSFLCQCGRGY---TGPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGF----TG 463

Query: 392 TQCIADKPEEKS 403
           T C  D  E +S
Sbjct: 464 TYCEVDIDECQS 475



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 15/37 (40%), Positives = 17/37 (45%), Gaps = 4/37 (10%)

Query: 110 VVVCPLPCMNGGQCSSRN----QCLCPPDFTGRFCQV 142
           V   P PC NGG C         C C P F G+ C+V
Sbjct: 199 VPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV 235



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 4/51 (7%)

Query: 116  PCMNGGQCS---SRNQCLCPPDFTGRFCQVPAGGAGGGTG-GSGPGLSRTG 162
            PC +GG C    +R  C CPP   G  C++     G G    SGP     G
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNG 1180



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 482  LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
            L+P  P  PQ+ P      P   +     G  +  P +    V   HP  T +P    PE
Sbjct: 2196 LNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPES--PE 2253

Query: 542  LISRPSPPTMRWFLPDLPPSRSA 564
              + PSPP++  +    P   +A
Sbjct: 2254 HWASPSPPSLSDWSESTPSPATA 2276



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 49/199 (24%), Positives = 74/199 (37%), Gaps = 28/199 (14%)

Query: 277 GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--PGPVR 334
           G C QD + +   G+NP   L +  +  GS     G+   +  P+ + T V +   GP R
Sbjct: 386 GACDQD-VDECSIGANPCEHLGRCVNTQGSFLCQCGRG--YTGPRCE-TDVNECLSGPCR 441

Query: 335 ---------GEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
                    G+    C  G+     T+C+ DI+EC        G C +    + C CP G
Sbjct: 442 NQATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498

Query: 385 HSLGPSR---TQCIADKPEEKSLCF-RLVSPEHQCQHPLT-TRLTRQLCCCSVGKAWGAR 439
            S    +    +C +      + C  +    E +C      T   R +  CS       R
Sbjct: 499 FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558

Query: 440 CQRCPTDGTAAFKEICPAG 458
           C     DG A+F   C  G
Sbjct: 559 C----VDGIASFSCACAPG 573



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 114 PLPCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           P  C NGG C    +   CLC P +TG  CQ
Sbjct: 930 PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  220 bits (560), Expect = 8e-57
 Identities = 233/860 (27%), Positives = 324/860 (37%), Gaps = 243/860 (28%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631
            + D C  N    G G+C+P    Y CHC P +   P  R   DVNEC  +P  C  G G 
Sbjct: 140  QADPCASNPCANG-GQCLPFEASYICHCPPSFHG-PTCRQ--DVNECGQKPGLCRHG-GT 194

Query: 632  CMNTGGSYNC---------HCNRGY------------------------RLHVGAGGRSC 658
            C N  GSY C         +C R Y                            G  G++C
Sbjct: 195  CHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNC 254

Query: 659  VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPD-G 716
             +  +    + C +GG C++    Y C C P +    +     ED+DEC+  P++C + G
Sbjct: 255  EENIDDCPGNNCKNGGACVDGVNTYNCRCPPEW----TGQYCTEDVDECQLMPNACQNGG 310

Query: 717  KCENKPGSFKCIACQPGYRSQG---------------GGACRD----------------- 744
             C N  G + C+ C  G+  +                G  C D                 
Sbjct: 311  TCHNTHGGYNCV-CVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLL 369

Query: 745  --VNECAEGSPCSPGW-CENLP--GSFRCTCAQGYAPAPDGRSC-LDVDECEAG-DVCDN 797
              +N+    +PC+ G  C+  P  G   CTC  GY     G +C  DVDEC  G + C++
Sbjct: 370  CHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYT----GPACSQDVDECSLGANPCEH 425

Query: 798  -GICSNTPGSFQCQCLSGYHLSR----------------------------------DRS 822
             G C NT GSF+CQCL GY   R                                  +  
Sbjct: 426  AGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV 485

Query: 823  HCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPH 880
            HCE + DEC        G C++    ++C CP G     G  CQ D+DEC+  P  C   
Sbjct: 486  HCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFT---GHLCQYDVDECASTP--CKNG 540

Query: 881  GACKNLQGSYVCVCDEGFTPTQDQHGCEEVE-QPHHKKECYLNFDDTVFCDSVLATNVTQ 939
              C +   +Y CVC EG+T T  +   +E +  P H   C                 V  
Sbjct: 541  AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSC--------------KDGVAT 586

Query: 940  QECCCSLGAGWGDHCEI-------YPCPVYSSAEFHS---LCPDGKGYTQDNNIVNYGIP 989
              C C  G   G HCE         PC    + +      LC   KG T  N  +N    
Sbjct: 587  FTCLCRPGY-TGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEIN---- 641

Query: 990  AHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049
                +D+C    S  C  G C++   GYEC C+ G  Y G++   +++DEC        G
Sbjct: 642  ----LDDC---ASSPCDSGTCLDKIDGYECACEPG--YTGSMCN-INIDECAGNPCHNGG 691

Query: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECR 1109
             CE+   G+ C C P   + P    CLS    +V+EC +   C  G C +    Y+C+C 
Sbjct: 692  TCEDGINGFTCRC-PEGYHDPT---CLS----EVNEC-NSNPCVHGACRDSLNGYKCDCD 742

Query: 1110 PPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRG 1169
            P W    SG +C +  +  E  P     C +     G C    +G       C CR+G  
Sbjct: 743  PGW----SGTNCDINNNECESNP-----CVN----GGTCKDMTSGYV-----CTCREG-- 782

Query: 1170 WGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEE-------DSDECR 1222
                        +G +C T+ +E  S    +P L      D+ +  +           C 
Sbjct: 783  -----------FSGPNCQTNINECAS----NPCLNQGTCIDDVAGYKCNCLLPYTGATCE 827

Query: 1223 CVSGRCVPRP---GGAV----------CECPGGFQLDASRARCVDIDECRELNQRGLLCK 1269
             V   C P P   GG            C CP G+Q        VDI+EC     R     
Sbjct: 828  VVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCE---VDINECVLSPCR----H 880

Query: 1270 SERCVNTSGSFRCVCKAGFA 1289
               C NT G +RC C+AG++
Sbjct: 881  GASCQNTHGGYRCHCQAGYS 900



 Score =  217 bits (553), Expect = 5e-56
 Identities = 219/755 (29%), Positives = 304/755 (40%), Gaps = 160/755 (21%)

Query: 569  PTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
            PT ++E +EC  N N C HG C      Y C C+PG+         ++ NECE+ PC  G
Sbjct: 711  PTCLSEVNEC--NSNPCVHGACRDSLNGYKCDCDPGWSGT---NCDINNNECESNPCVNG 765

Query: 629  RGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNC 687
             G C +    Y C C  G+       G +C  ++NECA  + C + G CI+    YKCNC
Sbjct: 766  -GTCKDMTSGYVCTCREGF------SGPNCQTNINECAS-NPCLNQGTCIDDVAGYKCNC 817

Query: 688  YPGYRLKASRPPVCEDIDECRDPSSCPDG-KCENKPG--SFKCIACQPGYRSQGGGACR- 743
               Y         CE +     PS C +G +C       SF C+ C  G++ Q    C  
Sbjct: 818  LLPYT-----GATCEVVLAPCAPSPCRNGGECRQSEDYESFSCV-CPTGWQGQ---TCEV 868

Query: 744  DVNECAEGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICS 801
            D+NEC   SPC  G  C+N  G +RC C  GY+    GR+C  D+D+C      + G C+
Sbjct: 869  DINECVL-SPCRHGASCQNTHGGYRCHCQAGYS----GRNCETDIDDCRPNPCHNGGSCT 923

Query: 802  NTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG 860
            +   +  C CL G+      + CE DI+EC       G +C +   SY C CP G     
Sbjct: 924  DGINTAFCDCLPGFR----GTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGF---S 976

Query: 861  GRKCQD-IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919
            G  C++   +C++  S C   G C +   S+ C+C  GFT +  QH   E +     + C
Sbjct: 977  GIHCENNTPDCTE--SSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDS----QPC 1030

Query: 920  YLNFDDTVFCDSVLAT---NVTQQEC-----------CCSLGAGWGDHCEIYPCPVYSSA 965
                     C S   T     T   C           C + G  W  H + Y C      
Sbjct: 1031 LHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ-YRCE----- 1084

Query: 966  EFHSLCPDG-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQ 1023
                 CP G  G   D   V+  + A R   +     + +C+ G  CV+    + C C+ 
Sbjct: 1085 -----CPSGWTGLYCDVPSVSCEVAAQRQGVDV----ARLCQHGGLCVDAGNTHHCRCQA 1135

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEEMD 1082
            G  Y G+  E + VDEC   S C+NG  C +  GGY C C   A Y      C      +
Sbjct: 1136 G--YTGSYCEDL-VDEC-SPSPCQNGATCTDYLGGYSCKCV--AGYHGVN--CSE----E 1183

Query: 1083 VDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR----DCQLPESPAERAPERRDVC 1138
            +DEC        G C++LP +Y+C C P    G        DC  P  P  R+P+    C
Sbjct: 1184 IDECLSHPCQNGGTCLDLPNTYKCSC-PRGTQGVHCEINVDDCNPPVDPVSRSPK----C 1238

Query: 1139 WSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1198
            ++    +G C   + G + T                  CPP   G  C    +E  S   
Sbjct: 1239 FN----NGTCVDQVGGYSCT------------------CPPGFVGERCEGDVNECLS--- 1273

Query: 1199 TSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVD-IDE 1257
                     P D   ++            CV R     CEC  G     +  RC   I+ 
Sbjct: 1274 --------NPCDARGTQN-----------CVQRVNDFHCECRAGH----TGRRCESVING 1310

Query: 1258 CRELNQRGLLCKSE-RCV---NTSGSFRCVCKAGF 1288
            C+     G  CK+   C    NT+  F C C AGF
Sbjct: 1311 CK-----GKPCKNGGTCAVASNTARGFICKCPAGF 1340



 Score =  213 bits (543), Expect = 7e-55
 Identities = 237/925 (25%), Positives = 338/925 (36%), Gaps = 263/925 (28%)

Query: 569  PTQVTETDECRLNQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP 627
            P    + DEC L  N C H G+C+     + C C  GY      R  +DVNEC + PC  
Sbjct: 407  PACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTG---PRCEIDVNECVSNPC-Q 462

Query: 628  GRGICMNTGGSYNCHCNRGYR----------------LH----------------VGAGG 655
                C++  G + C C  GY                 LH                 G  G
Sbjct: 463  NDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTG 522

Query: 656  RSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE-DIDECRDPSSC 713
              C  D++ECA    C +G  C++ P  Y C C  GY         CE DIDEC DP  C
Sbjct: 523  HLCQYDVDECASTP-CKNGAKCLDGPNTYTCVCTEGY-----TGTHCEVDIDEC-DPDPC 575

Query: 714  PDGKCENKPGSFKCIACQPGYRS---------------QGGGACRD-------------- 744
              G C++   +F C+ C+PGY                 + GG C+D              
Sbjct: 576  HYGSCKDGVATFTCL-CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTT 634

Query: 745  -------VNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCD 796
                   +++CA  SPC  G C +    + C C  GY     G  C +++DEC AG+ C 
Sbjct: 635  GPNCEINLDDCA-SSPCDSGTCLDKIDGYECACEPGYT----GSMCNINIDEC-AGNPCH 688

Query: 797  N-GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQG 855
            N G C +    F C+C  GYH   D +   +++EC+    C+ G C ++   Y+C C  G
Sbjct: 689  NGGTCEDGINGFTCRCPEGYH---DPTCLSEVNECN-SNPCVHGACRDSLNGYKCDCDPG 744

Query: 856  HRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT--------------P 900
                 G  C  + +EC  +P  C+  G CK++   YVC C EGF+              P
Sbjct: 745  W---SGTNCDINNNECESNP--CVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNP 799

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
              +Q  C + +   +K  C L +     C+ VLA        C       G  C      
Sbjct: 800  CLNQGTCID-DVAGYKCNCLLPYTGAT-CEVVLAP-------CAPSPCRNGGECR--QSE 848

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYEC 1019
             Y S  F  +CP G            G     DI+EC+L     C+ G  C NT  GY C
Sbjct: 849  DYES--FSCVCPTGW----------QGQTCEVDINECVL---SPCRHGASCQNTHGGYRC 893

Query: 1020 YCKQGF----------------YYDGN---------LLECV----------DVDECLDES 1044
            +C+ G+                 ++G            +C+          D++EC  + 
Sbjct: 894  HCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDP 953

Query: 1045 NCRNGV-CENTRGGYRCACTPPAEYSPAQRQ-------------------------CLSP 1078
             CRNG  C +    Y C C  PA +S    +                         CL P
Sbjct: 954  -CRNGANCTDCVDSYTCTC--PAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCP 1010

Query: 1079 E-------EMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
                    + DV+EC        G C +  GSYRC C      G +G +CQ      + +
Sbjct: 1011 PGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTC----PQGYTGPNCQNLVHWCDSS 1066

Query: 1132 P-ERRDVCWSQRGEDGMCAGPLAG-------PALTFDDCCCRQGRGWGAQCRP---CPPR 1180
            P +    CW Q      C  P          P+++ +    RQG      C+    C   
Sbjct: 1067 PCKNGGKCW-QTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDA 1125

Query: 1181 GAGSHCPTSQSESNSFWD-------TSPLLLGKPPRD--------------EDSSEEDSD 1219
            G   HC      + S+ +        SP   G    D                +  E+ D
Sbjct: 1126 GNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEID 1185

Query: 1220 EC---RCVS-GRCVPRPGGAVCECPGGFQLDASRARC-VDIDECR----ELNQRGLLCKS 1270
            EC    C + G C+  P    C CP G Q       C +++D+C      +++      +
Sbjct: 1186 ECLSHPCQNGGTCLDLPNTYKCSCPRGTQ----GVHCEINVDDCNPPVDPVSRSPKCFNN 1241

Query: 1271 ERCVNTSGSFRCVCKAGFARSRPHG 1295
              CV+  G + C C  GF   R  G
Sbjct: 1242 GTCVDQVGGYSCTCPPGFVGERCEG 1266



 Score =  151 bits (382), Expect = 3e-36
 Identities = 172/653 (26%), Positives = 232/653 (35%), Gaps = 171/653 (26%)

Query: 695  ASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPC 754
            A+R P C    E    +    GKCE   G+  C+ C   +    G  C+D N C   +PC
Sbjct: 18   AARGPRCSQPGE----TCLNGGKCEAANGTEACV-CGGAFV---GPRCQDPNPCLS-TPC 68

Query: 755  -SPGWCENLP----GSFRCTCAQGYAP----APDGRSCLDVDECEAGDVCDNGICSNTPG 805
             + G C  +       + C+CA G++      P   +CL  + C  G  CD      T  
Sbjct: 69   KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACL-TNPCRNGGTCD----LLTLT 123

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC- 864
             ++C+C  G+        C+  D C       GG C+    SY C CP       G  C 
Sbjct: 124  EYKCRCPPGW----SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH---GPTCR 176

Query: 865  QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFD 924
            QD++EC Q P LC   G C N  GSY CVC      T     CE    P     C     
Sbjct: 177  QDVNECGQKPGLCRHGGTCHNEVGSYRCVC----RATHTGPNCERPYVPCSPSPCQNG-- 230

Query: 925  DTVFCDSVLATNVTQQECCCSLGAGWGDHCE--IYPCPVYSSAEFHSLCPDGKGYTQDNN 982
                  +   T     EC C L    G +CE  I  CP        + C +G       N
Sbjct: 231  -----GTCRPTGDVTHECAC-LPGFTGQNCEENIDDCP-------GNNCKNGGACVDGVN 277

Query: 983  IVNYGIPAH-------RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG---NLL 1032
              N   P          D+DEC L  +     G C NT  GY C C  G+  +    N+ 
Sbjct: 278  TYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENID 337

Query: 1033 ECVDVDECLDESNCRNGV------CENTRGGYRC-------------------------- 1060
            +C     C   + C + V      C + R G  C                          
Sbjct: 338  DCASA-ACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKA 396

Query: 1061 ACTPPAEYS-PAQRQCLSPEEMDVDECQDPA-AC-RPGRCVNLPGSYRCECRPPWVPGPS 1117
             CT P+ Y+ PA  Q       DVDEC   A  C   G+C+N  GS+ C+C    + G +
Sbjct: 397  ICTCPSGYTGPACSQ-------DVDECSLGANPCEHAGKCINTLGSFECQC----LQGYT 445

Query: 1118 GRDCQLPESPAERAPERRD-VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP 1176
            G  C++  +     P + D  C  Q GE                            QC  
Sbjct: 446  GPRCEIDVNECVSNPCQNDATCLDQIGE---------------------------FQC-I 477

Query: 1177 CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAV 1236
            C P   G HC  +  E  S    SP L                     +GRC+ +     
Sbjct: 478  CMPGYEGVHCEVNTDECAS----SPCL--------------------HNGRCLDKINEFQ 513

Query: 1237 CECPGGFQLDASRARCVDIDECRELNQRGLLCKS-ERCVNTSGSFRCVCKAGF 1288
            CECP GF          D+DEC         CK+  +C++   ++ CVC  G+
Sbjct: 514  CECPTGF---TGHLCQYDVDECASTP-----CKNGAKCLDGPNTYTCVCTEGY 558



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 109/479 (22%), Positives = 161/479 (33%), Gaps = 110/479 (22%)

Query: 870  CSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFC 929
            CSQ    CL  G C+   G+  CVC   F   +    C++   P     C     +   C
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAFVGPR----CQD-PNPCLSTPC----KNAGTC 74

Query: 930  DSVLATNVTQQECCCSLGAGW-------GDHCEIYPC------PVYSSAEFHSLCPDGKG 976
              V    V    C C+LG           + C   PC       + +  E+   CP G  
Sbjct: 75   HVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG-- 132

Query: 977  YTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC-V 1035
                     +   + +  D C    +     G+C+  +  Y C+C   F+       C  
Sbjct: 133  ---------WSGKSCQQADPCA--SNPCANGGQCLPFEASYICHCPPSFHGP----TCRQ 177

Query: 1036 DVDECLDESN-CRNG-VCENTRGGYRCACTP------------PAEYSPAQR-------- 1073
            DV+EC  +   CR+G  C N  G YRC C              P   SP Q         
Sbjct: 178  DVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG 237

Query: 1074 ------QCLSPE-----EMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRD-- 1120
                   CL        E ++D+C        G CV+   +Y C C P W       D  
Sbjct: 238  DVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVD 297

Query: 1121 -CQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALT--FDDCCCRQGRGWGAQC--- 1174
             CQL  +  +      +   +  G + +C     G   +   DDC         A C   
Sbjct: 298  ECQLMPNACQNGGTCHN---THGGYNCVCVNGWTGEDCSENIDDCA-------SAACFHG 347

Query: 1175 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGG 1234
              C  R A  +C      +      +   +  P  +  + + +            P  G 
Sbjct: 348  ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTN------------PVNGK 395

Query: 1235 AVCECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGSFRCVCKAGFARSR 1292
            A+C CP G+      A   D+DEC   +     C+ + +C+NT GSF C C  G+   R
Sbjct: 396  AICTCPSGY---TGPACSQDVDEC---SLGANPCEHAGKCINTLGSFECQCLQGYTGPR 448



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 70/277 (25%), Positives = 101/277 (36%), Gaps = 35/277 (12%)

Query: 574  ETDECRLNQ-NICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDV-NECEAEPCGPGR-- 629
            + +EC  N  +  G   CV    D+ C C  G+      R C  V N C+ +PC  G   
Sbjct: 1267 DVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTG----RRCESVINGCKGKPCKNGGTC 1322

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY- 688
             +  NT   + C C  G+       G +C +         C +GG CI+ P    C C  
Sbjct: 1323 AVASNTARGFICKCPAGFE------GATCENDARTCGSLRCLNGGTCISGPRSPTCLCLG 1376

Query: 689  ----PGYRLKASRPPV----CEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG 740
                P  +  AS P +    C +   C   S  P  +C   P  F  + C     S GGG
Sbjct: 1377 PFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLC-PAKFNGLLCHILDYSFGGG 1435

Query: 741  ACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSC-LDVDE----CEAGDV 794
            A RD+        C    C+   G+  C+     +A   DG  C L+ ++    C     
Sbjct: 1436 AGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQ 1495

Query: 795  C----DNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
            C     +G C +   S  C    G+   R    C  +
Sbjct: 1496 CWKYFSDGHCDSQCNSAGC-LFDGFDCQRAEGQCNPL 1531



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 50/124 (40%), Gaps = 13/124 (10%)

Query: 341 CPQGYKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCVCPPGHSLGPS----RTQC 394
           CP  +     T  QD+NEC   PG+CRHG  C N  GSYRCVC   H+ GP+       C
Sbjct: 166 CPPSFH--GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHT-GPNCERPYVPC 222

Query: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQR--CPTDGTAAFK 452
                +    C       H+C        T Q C  ++    G  C+      DG   + 
Sbjct: 223 SPSPCQNGGTCRPTGDVTHEC--ACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYN 280

Query: 453 EICP 456
             CP
Sbjct: 281 CRCP 284



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 10/90 (11%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAM-PGVCRH-GDCLNNPGSYRCVCPPGHSLGP 389
           PV G+    CP GY        QD++EC++    C H G C+N  GS+ C C  G++ GP
Sbjct: 391 PVNGKAICTCPSGYT--GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT-GP 447

Query: 390 ----SRTQCIADKPEEKSLCFRLVSPEHQC 415
                  +C+++  +  + C   +  E QC
Sbjct: 448 RCEIDVNECVSNPCQNDATCLDQIG-EFQC 476



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 36/134 (26%), Positives = 52/134 (38%), Gaps = 20/134 (14%)

Query: 335 GEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHS---LGPS 390
           G     C QGY       C+ D+NEC          CL+  G ++C+C PG+       +
Sbjct: 434 GSFECQCLQGY---TGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVN 490

Query: 391 RTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC------CCSVGKAWGARCQRCP 444
             +C +        C   ++ E QC+ P  T  T  LC      C S     GA+C    
Sbjct: 491 TDECASSPCLHNGRCLDKIN-EFQCECP--TGFTGHLCQYDVDECASTPCKNGAKC---- 543

Query: 445 TDGTAAFKEICPAG 458
            DG   +  +C  G
Sbjct: 544 LDGPNTYTCVCTEG 557



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 34/118 (28%)

Query: 341  CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
            CP G+     ++CQ D+NEC        G C +  GSYRC CP G++ GP+         
Sbjct: 1009 CPPGF---TGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYT-GPN--------- 1055

Query: 400  EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQ---RCPTDGTAAFKEI 454
                 C  LV   H C             C + GK W    Q    CP+  T  + ++
Sbjct: 1056 -----CQNLV---HWCD---------SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDV 1096



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 38/119 (31%), Positives = 44/119 (36%), Gaps = 34/119 (28%)

Query: 289 CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP-QLQYTGVQ--------KPGPVRG---- 335
           C SNP          C + GT       +KC   L YTG           P P R     
Sbjct: 795 CASNP----------CLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGEC 844

Query: 336 -------EVGADCPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHS 386
                       CP G++    T   DINEC +   CRHG  C N  G YRC C  G+S
Sbjct: 845 RQSEDYESFSCVCPTGWQ--GQTCEVDINECVL-SPCRHGASCQNTHGGYRCHCQAGYS 900



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 18/47 (38%), Positives = 28/47 (59%), Gaps = 5/47 (10%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
           C +GY     THC+ DI+EC  P  C +G C +   ++ C+C PG++
Sbjct: 554 CTEGY---TGTHCEVDIDECD-PDPCHYGSCKDGVATFTCLCRPGYT 596



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 37/118 (31%), Positives = 50/118 (42%), Gaps = 17/118 (14%)

Query: 354 QDINECA-MPGVCRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCF----- 406
           +D++EC  MP  C++G  C N  G Y CVC  G + G   ++ I D     + CF     
Sbjct: 294 EDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWT-GEDCSENIDDC--ASAACFHGATC 350

Query: 407 --RLVSPEHQCQHPLTTRLTR-QLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461
             R+ S   +C H  T  L      C S     G+ C   P +G    K IC    GY
Sbjct: 351 HDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNG----KAICTCPSGY 404



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 42/138 (30%), Positives = 55/138 (39%), Gaps = 38/138 (27%)

Query: 340  DCPQGYKRLNSTHCQ-DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIAD 397
            DC  G++    T C+ DINECA    CR+G +C +   SY C CP G     S   C  +
Sbjct: 932  DCLPGFR---GTFCEEDINECASDP-CRNGANCTDCVDSYTCTCPAGF----SGIHCENN 983

Query: 398  KPE-EKSLCFR-------------LVSP---EHQCQHPLTTRLTRQLCCCSVGKAWGARC 440
             P+  +S CF              L  P      CQH +         C S     G  C
Sbjct: 984  TPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNE-------CDSQPCLHGGTC 1036

Query: 441  QRCPTDGTAAFKEICPAG 458
            Q    DG  +++  CP G
Sbjct: 1037 Q----DGCGSYRCTCPQG 1050



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 3/46 (6%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
           CP+GY   + T   ++NEC     C HG C ++   Y+C C PG S
Sbjct: 704 CPEGYH--DPTCLSEVNECNS-NPCVHGACRDSLNGYKCDCDPGWS 746



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
           CP G+   +   CQ  + CA       G CL    SY C CPP    GP+  Q + +  +
Sbjct: 129 CPPGW---SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH-GPTCRQDVNECGQ 184

Query: 401 EKSLC 405
           +  LC
Sbjct: 185 KPGLC 189



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 38/130 (29%), Positives = 54/130 (41%), Gaps = 19/130 (14%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGD-CLNNPGSYRCVCPPGHSLGPS---RTQCI 395
           C  GY      HC+ +INEC+    CRHG  C +   +Y C C  G + GP+        
Sbjct: 591 CRPGY---TGHHCETNINECSSQP-CRHGGTCQDRDNAYLCFCLKG-TTGPNCEINLDDC 645

Query: 396 ADKPEEKSLCF-RLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT--DGTAAFK 452
           A  P +   C  ++   E  C+       T  +C  ++ +  G  C    T  DG   F 
Sbjct: 646 ASSPCDSGTCLDKIDGYECACE----PGYTGSMCNINIDECAGNPCHNGGTCEDGINGFT 701

Query: 453 EICPAGKGYH 462
             CP  +GYH
Sbjct: 702 CRCP--EGYH 709



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 24/71 (33%), Positives = 32/71 (45%), Gaps = 14/71 (19%)

Query: 82   DSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCP--------LPCMNGGQCS---SRNQCL 130
            D C+ G+N T   ++   T     +GF  + C           C NGG C    +   CL
Sbjct: 952  DPCRNGANCTDCVDSYTCT---CPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCL 1008

Query: 131  CPPDFTGRFCQ 141
            CPP FTG +CQ
Sbjct: 1009 CPPGFTGSYCQ 1019



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 22/66 (33%), Positives = 30/66 (45%), Gaps = 8/66 (12%)

Query: 336 EVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           E   +CP G+       CQ D++ECA         CL+ P +Y CVC  G+    + T C
Sbjct: 511 EFQCECPTGF---TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY----TGTHC 563

Query: 395 IADKPE 400
             D  E
Sbjct: 564 EVDIDE 569



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 14/32 (43%), Positives = 21/32 (65%), Gaps = 3/32 (9%)

Query: 116  PCMNGGQC---SSRNQCLCPPDFTGRFCQVPA 144
            PC NGG+C    ++ +C CP  +TG +C VP+
Sbjct: 1067 PCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS 1098



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            G     C  GY  +N +  ++I+EC        G CL+ P +Y+C CP G
Sbjct: 1165 GGYSCKCVAGYHGVNCS--EEIDECLSHPCQNGGTCLDLPNTYKCSCPRG 1212



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 5/46 (10%)

Query: 116  PCMNGGQCSSRNQ-----CLCPPDFTGRFCQVPAGGAGGGTGGSGP 156
            PC N G C   ++     CLCP  F G  C +     GGG G   P
Sbjct: 1396 PCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIP 1441



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 20/50 (40%), Positives = 22/50 (44%), Gaps = 8/50 (16%)

Query: 116 PCMNGGQC---SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTG 162
           PC NGGQC    +   C CPP F G  C+           G  PGL R G
Sbjct: 148 PCANGGQCLPFEASYICHCPPSFHGPTCRQDVNEC-----GQKPGLCRHG 192



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 21/66 (31%), Positives = 28/66 (42%), Gaps = 9/66 (13%)

Query: 84  CQQGSNMTLIGENGHSTDTL---TGSGFRVVVCPLP---CMNGGQCS---SRNQCLCPPD 134
           CQ G      G+  H    L   TG      +   P   C NGG C    +   C CPP+
Sbjct: 227 CQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPE 286

Query: 135 FTGRFC 140
           +TG++C
Sbjct: 287 WTGQYC 292



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 8/47 (17%)

Query: 104 TGSGFRVVVCPL---PCMNGGQCSSRN-----QCLCPPDFTGRFCQV 142
           TG+   VV+ P    PC NGG+C          C+CP  + G+ C+V
Sbjct: 822 TGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 11/72 (15%)

Query: 84   CQQGSNMTLIGENGHSTDTLTGSGFRVVVCP--------LPCMNGGQCSSRNQ---CLCP 132
            C+ G    +             +GF    C         L C+NGG C S  +   CLC 
Sbjct: 1316 CKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCL 1375

Query: 133  PDFTGRFCQVPA 144
              FTG  CQ PA
Sbjct: 1376 GPFTGPECQFPA 1387



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 4/32 (12%)

Query: 114 PLPCMNGGQCSSR----NQCLCPPDFTGRFCQ 141
           P PC NGG C       ++C C P FTG+ C+
Sbjct: 224 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCE 255



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 33/141 (23%)

Query: 341  CPQGYKRLNSTHCQ-DINEC--------AMPGVCRHGDCLNNPGSYRCVCPP---GHSLG 388
            CP+G +     HC+ ++++C          P    +G C++  G Y C CPP   G    
Sbjct: 1209 CPRGTQ---GVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1265

Query: 389  PSRTQCIADKPEEKSL--CFRLVSPEH-QCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT 445
                +C+++  + +    C + V+  H +C+   T R      C SV    G + + C  
Sbjct: 1266 GDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRR-----CESVIN--GCKGKPCKN 1318

Query: 446  DGTAA--------FKEICPAG 458
             GT A        F   CPAG
Sbjct: 1319 GGTCAVASNTARGFICKCPAG 1339



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 13/30 (43%), Positives = 18/30 (60%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCS----SRNQCLCPPDFTGRFCQ 141
           PC NGG C     +  +C CPP ++G+ CQ
Sbjct: 110 PCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ 139



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 20/53 (37%), Positives = 23/53 (43%), Gaps = 12/53 (22%)

Query: 116  PCMNGGQCSSRNQ------CLCPPDFTGRFCQVPAGGAG------GGTGGSGP 156
            PC NGG C+  +       C CP  F G  C+  A   G      GGT  SGP
Sbjct: 1315 PCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGP 1367



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PC++ G+C  +    QC CP  FTG  CQ
Sbjct: 498 PCLHNGRCLDKINEFQCECPTGFTGHLCQ 526



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 22/89 (24%), Positives = 31/89 (34%), Gaps = 8/89 (8%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQ---CLC 131
           C  G C+D     + +   G  GH  +T             PC +GG C  R+    C C
Sbjct: 575 CHYGSCKDGVATFTCLCRPGYTGHHCETNINE-----CSSQPCRHGGTCQDRDNAYLCFC 629

Query: 132 PPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160
               TG  C++           SG  L +
Sbjct: 630 LKGTTGPNCEINLDDCASSPCDSGTCLDK 658



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 22/86 (25%), Positives = 39/86 (45%), Gaps = 8/86 (9%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPG-HSLGPSR--TQCIA 396
            C  GY     ++C+D+ +   P  C++G  C +  G Y C C  G H +  S    +C++
Sbjct: 1133 CQAGY---TGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLS 1189

Query: 397  DKPEEKSLCFRLVSPEHQCQHPLTTR 422
               +    C  L +  ++C  P  T+
Sbjct: 1190 HPCQNGGTCLDLPN-TYKCSCPRGTQ 1214



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 24/78 (30%), Positives = 31/78 (39%), Gaps = 24/78 (30%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQC--- 123
           C+ G CRDS            NG+  D     G+    C +        PC+NGG C   
Sbjct: 725 CVHGACRDSL-----------NGYKCDC--DPGWSGTNCDINNNECESNPCVNGGTCKDM 771

Query: 124 SSRNQCLCPPDFTGRFCQ 141
           +S   C C   F+G  CQ
Sbjct: 772 TSGYVCTCREGFSGPNCQ 789



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 14/31 (45%), Positives = 17/31 (54%), Gaps = 3/31 (9%)

Query: 114 PLPCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           P PC NGG C+   +   C C P F G FC+
Sbjct: 913 PNPCHNGGSCTDGINTAFCDCLPGFRGTFCE 943



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVC 381
           C +G+   N   CQ +INECA       G C+++   Y+C C
Sbjct: 779 CREGFSGPN---CQTNINECASNPCLNQGTCIDDVAGYKCNC 817



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 117 CMNGGQCSSRN---QCLCPPDFTGRFCQVP 143
           C+NGG+C + N    C+C   F G  CQ P
Sbjct: 31  CLNGGKCEAANGTEACVCGGAFVGPRCQDP 60



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 12/29 (41%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116  PCMNGGQCSS---RNQCLCPPDFTGRFCQ 141
            PC++GG C       +C CP  +TG  CQ
Sbjct: 1029 PCLHGGTCQDGCGSYRCTCPQGYTGPNCQ 1057


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  217 bits (553), Expect = 5e-56
 Identities = 219/771 (28%), Positives = 286/771 (37%), Gaps = 167/771 (21%)

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC--EAEPCGPGRGICM 633
            D C  N  + G G C+   P   CHC PG+  H   R   DVNEC  +  PC  G   C 
Sbjct: 158  DFCSANPCVNG-GVCLATYPQIQCHCPPGFEGHACER---DVNECFQDPGPCPKGTS-CH 212

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFP----GHYKCNCYP 689
            NT GS+ C C       VG  G  C        P  C +GG C   P      + C C P
Sbjct: 213  NTLGSFQCLC------PVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266

Query: 690  GYRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNEC 748
            G+       P CE + D C        G C++   ++ C+  +      G     DV+EC
Sbjct: 267  GF-----IGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETW---TGWDCSEDVDEC 318

Query: 749  AEGSP--C-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGICSNTP 804
                P  C + G C+N  GSF C C  G+     G SC + +D+C A        C +  
Sbjct: 319  ETQGPPHCRNGGTCQNSAGSFHCVCVSGWG----GTSCEENLDDCIAATCAPGSTCIDRV 374

Query: 805  GSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN---GSYRCLCPQGHRLVGG 861
            GSF C C  G    R    C   D C     C G    +TN   GS  CLC  G+    G
Sbjct: 375  GSFSCLCPPG----RTGLLCHLEDMC-LSQPCHGDAQCSTNPLTGSTLCLCQPGY---SG 426

Query: 862  RKC-QDIDEC---SQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ---DQHGCEEVEQPH 914
              C QD+DEC    Q PS C   G+C N  GS+ C+C  G+T ++   D + C  + QP 
Sbjct: 427  PTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC--LSQPC 484

Query: 915  HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDG 974
            H             C  +LAT                               FH LCP G
Sbjct: 485  HPGST---------CLDLLAT-------------------------------FHCLCPPG 504

Query: 975  KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC 1034
                        G     + +EC    +       C +   G++C C  GF   G   E 
Sbjct: 505  L----------EGQLCEVETNECA--SAPCLNHADCHDLLNGFQCICLPGF--SGTRCE- 549

Query: 1035 VDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRP 1094
             D+DEC        G C++  G + C C P  E    Q         +VDEC        
Sbjct: 550  EDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQ--------TEVDECLSDPCPVG 601

Query: 1095 GRCVNLPGSYRCECRPPWVPGPSGRDCQLPESP--AERAPERRDVCWSQRGE-DGMCAGP 1151
              C++LPG++ C C       PSG   QL E P  A    + + +C  Q+ + + +C   
Sbjct: 602  ASCLDLPGAFFCLC-------PSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDG 654

Query: 1152 LAGPALTFDDCCCRQGR----------GW-GAQCR---------PCPPRGAGSHCPTSQS 1191
              G A   D+C C  G           GW G +C          PC      +H  T   
Sbjct: 655  SPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPC------AHGGTCYP 708

Query: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECP---GGFQLDAS 1248
            + + +  T P     P   E+ +   S  C    G C P PGG  C CP    G Q   S
Sbjct: 709  QPSGYNCTCPTGYTGPTCSEEMTACHSGPC-LNGGSCNPSPGGYYCTCPPSHTGPQCQTS 767

Query: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1299
               CV                   CVN  G+F C+C  GF   R  G   P
Sbjct: 768  TDYCVSAP----------CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRP 808



 Score =  209 bits (531), Expect = 2e-53
 Identities = 208/755 (27%), Positives = 296/755 (39%), Gaps = 114/755 (15%)

Query: 578  CRLNQNICGHGECVPGPP------DYSCHCNPGYRSHPQHRYCVDVNECEAEPC-GPGRG 630
            C  N + C    C PG         +SC C PG         C   + C ++PC G  + 
Sbjct: 352  CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTG----LLCHLEDMCLSQPCHGDAQC 407

Query: 631  ICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAK----PHLCGDGGFCINFPGHYKC 685
                  GS  C C  GY       G +C  DL+EC      P  C  GG C+N PG + C
Sbjct: 408  STNPLTGSTLCLCQPGY------SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461

Query: 686  NCYPGYRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR- 743
             C PGY    SR   CE D +EC      P   C +   +F C+ C PG   Q    C  
Sbjct: 462  LCPPGYT--GSR---CEADHNECLSQPCHPGSTCLDLLATFHCL-CPPGLEGQ---LCEV 512

Query: 744  DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL-DVDECEAGDVCDNGICSN 802
            + NECA     +   C +L   F+C C  G++    G  C  D+DEC +    + G C +
Sbjct: 513  ETNECASAPCLNHADCHDLLNGFQCICLPGFS----GTRCEEDIDECRSSPCANGGQCQD 568

Query: 803  TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGR 862
             PG+F C+CL G+   R ++   ++DEC      +G  C++  G++ CLCP G     G+
Sbjct: 569  QPGAFHCKCLPGFEGPRCQT---EVDECLSDPCPVGASCLDLPGAFFCLCPSGFT---GQ 622

Query: 863  KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE---GFTPTQDQHGCEEVEQPHHKKEC 919
             C ++  C+  P+LC P   CK+ +    C+C +   G  P +D   C           C
Sbjct: 623  LC-EVPLCA--PNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVC 679

Query: 920  YLNFDDTVFCDSVLATNVTQ--------------QECCCSLGAGWGDHC--EIYPCPVYS 963
             + +     C++ L   ++                 C C  G   G  C  E+  C    
Sbjct: 680  DVGWTGPE-CEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY-TGPTCSEEMTACHSGP 737

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
                 S  P   GY       + G       D C+   +     G CVN    + C C  
Sbjct: 738  CLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCV--SAPCFNGGTCVNRPGTFSCLCAM 795

Query: 1024 GFYYDGNLLECVDVDECLDESNCRN-GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMD 1082
            GF   G   E      C D S CRN   C+++  G RC C  P  Y+    Q L      
Sbjct: 796  GF--QGPRCEGKLRPSCAD-SPCRNRATCQDSPQGPRCLC--PTGYTGGSCQTL------ 844

Query: 1083 VDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQR 1142
            +D C      R   C+    S+ C C   W    +G  C LP S  ++A   + +  S  
Sbjct: 845  MDLCAQKPCPRNSHCLQTGPSFHCLCLQGW----TGPLCNLPLSSCQKAALSQGIDVSSL 900

Query: 1143 GED-GMCAGPLAGPALTFDDCCCRQGRGWGAQCR----PCPPRGAGSHCPTSQSESNSFW 1197
              + G+C    +GP+     C C  G   G+ C+    PC  R      P     +    
Sbjct: 901  CHNGGLCVD--SGPSYF---CHCPPG-FQGSLCQDHVNPCESR------PCQNGATCMAQ 948

Query: 1198 DTSPLLLGKPPRDEDSSEEDSDECRCV----SGRCVPRPGGAVCECPGGFQLDASRARCV 1253
             +  L    P  D  +  ++ D C+       G C P+PGG  C CP GF       RC 
Sbjct: 949  PSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGF----VGLRCE 1004

Query: 1254 -DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
             D+DEC  L+Q      +  C + + +F C C  G
Sbjct: 1005 GDVDEC--LDQPCHPTGTAACHSLANAFYCQCLPG 1037



 Score =  189 bits (479), Expect = 2e-47
 Identities = 319/1259 (25%), Positives = 421/1259 (33%), Gaps = 333/1259 (26%)

Query: 214  PGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPK--PSHPRPP 271
            PG +    Q P P  N ++                  ++    Q LLP P   PS P P 
Sbjct: 55   PGFLGETCQFPDPCQNAQL-----------------CQNGGSCQALLPAPLGLPSSPSPL 97

Query: 272  TQKPLGRCFQDTLPKQPCGSNPLPGLT------KQED-----CCGSIGT----AWGQSKC 316
            T   L  C              LPG T      K ED      C   G     A G+ +C
Sbjct: 98   TPSFLCTC--------------LPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQC 143

Query: 317  HKCP-----QLQYTGVQKPGP-VRG--------EVGADCPQGYKRLNSTHCQ-DINECAM 361
               P     Q Q        P V G        ++   CP G++      C+ D+NEC  
Sbjct: 144  SCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFE---GHACERDVNECFQ 200

Query: 362  -PGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPL 419
             PG C  G  C N  GS++C+CP G   GP         P       R  S    CQ   
Sbjct: 201  DPGPCPKGTSCHNTLGSFQCLCPVGQE-GPRCELRAGPCPP------RGCSNGGTCQLMP 253

Query: 420  TTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTL---TIQGES 476
                T  LC C  G   G  C+  P +                   SHQ     T Q   
Sbjct: 254  EKDSTFHLCLCPPGFI-GPDCEVNPDN-----------------CVSHQCQNGGTCQDGL 295

Query: 477  DFSLFLHPD---GPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATT 533
            D    L P+   G    + + E  +Q PP        G T  +       V  S    T+
Sbjct: 296  DTYTCLCPETWTGWDCSEDVDECETQGPP----HCRNGGTCQNSAGSFHCVCVSGWGGTS 351

Query: 534  TPARPYPELISRPSPPT-----MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHG 588
                    + +  +P +     +  F    PP R+ +      +   ++  L+Q   G  
Sbjct: 352  CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGL------LCHLEDMCLSQPCHGDA 405

Query: 589  ECVPGPPDYS--CHCNPGYRSHPQHRYCVDVNECEAEPCGPG----RGICMNTGGSYNCH 642
            +C   P   S  C C PGY     H+   D++EC     GP      G C+NT GS+NC 
Sbjct: 406  QCSTNPLTGSTLCLCQPGYSGPTCHQ---DLDECLMAQQGPSPCEHGGSCLNTPGSFNCL 462

Query: 643  CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK-------- 694
            C  GY      G R   D NEC     C  G  C++    + C C PG   +        
Sbjct: 463  CPPGY-----TGSRCEADHNECLS-QPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516

Query: 695  -ASRP---------------PVC----------EDIDECRDPSSCPDGKCENKPGSFKCI 728
             AS P                +C          EDIDECR       G+C+++PG+F C 
Sbjct: 517  CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHC- 575

Query: 729  ACQPGYRSQGGGACRDVNECAEGSPCSPG-WCENLPGSFRCTCAQGY------APAPDGR 781
             C PG+  +G     +V+EC    PC  G  C +LPG+F C C  G+       P     
Sbjct: 576  KCLPGF--EGPRCQTEVDECL-SDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN 632

Query: 782  SCLDVDEC-----EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE----------D 826
             C     C     +A  +C +G     P    C C  G H  R    C+          +
Sbjct: 633  LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHG-HCQRSSCVCDVGWTGPECEAE 691

Query: 827  IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNL 886
            +  C       GG C      Y C CP G+   G    +++  C   P  CL  G+C   
Sbjct: 692  LGGCISAPCAHGGTCYPQPSGYNCTCPTGY--TGPTCSEEMTACHSGP--CLNGGSCNPS 747

Query: 887  QGSYVCVCDEGFTPTQDQHGCEE-VEQPHHKKECYLNFDDTVFC---------------- 929
             G Y C C    T  Q Q   +  V  P       +N   T  C                
Sbjct: 748  PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLR 807

Query: 930  ----DSVLATNVTQQE------CCCSLGAGWG------DHCEIYPCP-----VYSSAEFH 968
                DS      T Q+      C C  G   G      D C   PCP     + +   FH
Sbjct: 808  PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFH 867

Query: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECM-------LFGSEICKE-GKCVNTQPGYECY 1020
             LC   +G+T        G   +  +  C        +  S +C   G CV++ P Y C+
Sbjct: 868  CLCL--QGWT--------GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCH 917

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTP-------PAEYSPAQ 1072
            C  GF   G+L  C D     +   C+NG  C     GY C C P         E    Q
Sbjct: 918  CPPGF--QGSL--CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQ 973

Query: 1073 RQ----------------CLSPE-------EMDVDECQDPAACRP---GRCVNLPGSYRC 1106
             Q                C  P        E DVDEC D   C P     C +L  ++ C
Sbjct: 974  SQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLD-QPCHPTGTAACHSLANAFYC 1032

Query: 1107 ECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1166
            +C    +PG +G+ C++   P          C SQ    G      AG  L F  C C +
Sbjct: 1033 QC----LPGHTGQWCEVEIDP----------CHSQPCFHGGTCEATAGSPLGF-ICHCPK 1077

Query: 1167 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1226
            G   G  C    P     HC             SP   G PPR           C C+SG
Sbjct: 1078 GFE-GPTCSHRAPSCGFHHC-----HHGGLCLPSP-KPGFPPR-----------CACLSG 1119

Query: 1227 RCVPRPGGAVCECPGGFQLDASRARCVDIDECRE---LNQRGLLCKSERCVNTSGSFRC 1282
                  GG  C  P   +     + C+    C E   L   G  C    C ++S   RC
Sbjct: 1120 Y-----GGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCS---CPHSSPGPRC 1170



 Score =  184 bits (466), Expect = 6e-46
 Identities = 216/820 (26%), Positives = 294/820 (35%), Gaps = 196/820 (23%)

Query: 569  PTQVTETDECRLNQ---NICGHG-ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP 624
            PT   + DEC + Q   + C HG  C+  P  ++C C PGY      R   D NEC ++P
Sbjct: 427  PTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGS---RCEADHNECLSQP 483

Query: 625  CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHY 683
            C PG   C++   +++C C  G        G+ C V+ NECA    C +   C +    +
Sbjct: 484  CHPG-STCLDLLATFHCLCPPGLE------GQLCEVETNECASAP-CLNHADCHDLLNGF 535

Query: 684  KCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR 743
            +C C PG+    S     EDIDECR       G+C+++PG+F C  C PG+    G  C+
Sbjct: 536  QCICLPGF----SGTRCEEDIDECRSSPCANGGQCQDQPGAFHC-KCLPGFE---GPRCQ 587

Query: 744  -DVNECAEGSPCSPGW-CENLPGSFRCTCAQGYA------PAPDGRSCLDVDECE----- 790
             +V+EC    PC  G  C +LPG+F C C  G+       P      C     C+     
Sbjct: 588  TEVDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDK 646

Query: 791  AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE----------DIDECDFPAACIGGD 840
            A  +C +G     P    C C  G H  R    C+          ++  C       GG 
Sbjct: 647  ANCLCPDGSPGCAPPEDNCTCHHG-HCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGT 705

Query: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
            C      Y C CP G+   G    +++  C   P  CL  G+C    G Y C C    T 
Sbjct: 706  CYPQPSGYNCTCPTGY--TGPTCSEEMTACHSGP--CLNGGSCNPSPGGYYCTCPPSHTG 761

Query: 901  TQDQHGCEE-VEQPHHKKECYLNFDDTVFC--------------------DSVLATNVTQ 939
             Q Q   +  V  P       +N   T  C                    DS      T 
Sbjct: 762  PQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC 821

Query: 940  QE------CCCSLGAGWG------DHCEIYPCP-----VYSSAEFHSLCPDGKGYTQDNN 982
            Q+      C C  G   G      D C   PCP     + +   FH LC   +G+T    
Sbjct: 822  QDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCL--QGWT---- 875

Query: 983  IVNYGIPAHRDIDECMLFG-------SEICKEGK-CVNTQPGYECYCKQGFYYDGNLLEC 1034
                G   +  +  C           S +C  G  CV++ P Y C+C  GF   G+L  C
Sbjct: 876  ----GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGF--QGSL--C 927

Query: 1035 VDVDECLDESNCRNGV-CENTRGGYRCACTP-------PAEYSPAQRQ------------ 1074
             D     +   C+NG  C     GY C C P         E    Q Q            
Sbjct: 928  QDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKP 987

Query: 1075 ----CLSPE-------EMDVDECQDPAACRP---GRCVNLPGSYRCECRPPWVPGPSGRD 1120
                C  P        E DVDEC D   C P     C +L  ++ C+C    +PG +G+ 
Sbjct: 988  GGFHCACPPGFVGLRCEGDVDECLDQP-CHPTGTAACHSLANAFYCQC----LPGHTGQW 1042

Query: 1121 CQLPESPAERAPERRD-------------VCWSQRGEDGMCAGPLAGPALTFDDC----- 1162
            C++   P    P                 +C   +G +G      A P+  F  C     
Sbjct: 1043 CEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA-PSCGFHHCHHGGL 1101

Query: 1163 -------------CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPR 1209
                          C  G G      P  P+G G   P   + S S  +T+ L     P 
Sbjct: 1102 CLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCS--ETTGL---GGPG 1156

Query: 1210 DEDSSEEDSDECRCV---SGRCVPRPGGAVCEC----PGG 1242
               S    S   RC    +  C  R G   C+     PGG
Sbjct: 1157 FRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGG 1196



 Score =  164 bits (414), Expect = 7e-40
 Identities = 234/996 (23%), Positives = 323/996 (32%), Gaps = 231/996 (23%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGV--CRHGD-CLNNPGSYRCVCPPGH---SLGPSRTQC 394
            CP+ +   + +  +D++EC   G   CR+G  C N+ GS+ CVC  G    S   +   C
Sbjct: 302  CPETWTGWDCS--EDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC 359

Query: 395  IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQL--CCCSVGKAWGARCQRCPTDGTAAFK 452
            IA      S C   V        P  T L   L   C S      A+C   P  G+    
Sbjct: 360  IAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGST--- 416

Query: 453  EICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGV 512
             +C    GY   T HQ        D    L     P P +   S    P   +     G 
Sbjct: 417  -LCLCQPGYSGPTCHQ--------DLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY 467

Query: 513  TTDSPVSEERSV--QQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
            T     ++      Q  HP +T          +    PP +   L ++            
Sbjct: 468  TGSRCEADHNECLSQPCHPGSTCLDLLATFHCLC---PPGLEGQLCEV------------ 512

Query: 571  QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRG 630
               ET+EC  +     H +C      + C C PG+      R   D++EC + PC  G G
Sbjct: 513  ---ETNECA-SAPCLNHADCHDLLNGFQCICLPGFSGT---RCEEDIDECRSSPCANG-G 564

Query: 631  ICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPG 690
             C +  G+++C C  G+      G R   +++EC     C  G  C++ PG + C C  G
Sbjct: 565  QCQDQPGAFHCKCLPGFE-----GPRCQTEVDECLSDP-CPVGASCLDLPGAFFCLCPSG 618

Query: 691  Y-----RLKASRPPVCEDIDECRDPSS-----CPDGKCENKPGSFKCIACQPGYRSQGGG 740
            +      +    P +C+    C+D        CPDG     P    C  C  G+  +   
Sbjct: 619  FTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNC-TCHHGHCQRSSC 677

Query: 741  ACRDVN----ECAE------GSPCSPGW-CENLPGSFRCTCAQGYA-------------- 775
             C DV     EC         +PC+ G  C   P  + CTC  GY               
Sbjct: 678  VC-DVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSG 736

Query: 776  ---------PAPDGRSCL------------DVDECEAGDVCDNGICSNTPGSFQCQCLSG 814
                     P+P G  C               D C +    + G C N PG+F C C  G
Sbjct: 737  PCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMG 796

Query: 815  YH---------------LSRDRSHCEDIDE---CDFPAACIGGDC--------------- 841
            +                  R+R+ C+D  +   C  P    GG C               
Sbjct: 797  FQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRN 856

Query: 842  ---INTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDP--------SLCLPHGACKNLQGS 889
               + T  S+ CLC QG     G  C   +  C +          SLC   G C +   S
Sbjct: 857  SHCLQTGPSFHCLCLQGWT---GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPS 913

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVL---ATNVTQQECCCSL 946
            Y C C  GF  +     C++   P   + C             L   A     Q C   L
Sbjct: 914  YFCHCPPGFQGSL----CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL 969

Query: 947  GAGWGDHCEIYPCPVYSSAE-----FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001
                 D C+  PC  + +       FH  CP G            G+    D+DEC+   
Sbjct: 970  -----DACQSQPCHNHGTCTPKPGGFHCACPPGF----------VGLRCEGDVDECLDQP 1014

Query: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRG---GY 1058
                    C +    + C C  G  + G   E V++D C  +     G CE T G   G+
Sbjct: 1015 CHPTGTAACHSLANAFYCQCLPG--HTGQWCE-VEIDPCHSQPCFHGGTCEATAGSPLGF 1071

Query: 1059 RCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPG-------RCVNLPGSYRCECRPP 1111
             C C    E      +  S        C     C P        RC  L G    +C  P
Sbjct: 1072 ICHCPKGFEGPTCSHRAPS---CGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP 1128

Query: 1112 WVP---------------------GPSGRDCQLPES-PAERAPERRDVCWSQRGEDGMCA 1149
              P                     G  G  C  P S P  R  +        R  DG C 
Sbjct: 1129 PAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACD 1188

Query: 1150 GPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH 1185
               +GP   +D   C  G        P P +G  SH
Sbjct: 1189 AGCSGPGGNWDGGDCSLG-------VPDPWKGCPSH 1217



 Score =  159 bits (403), Expect = 1e-38
 Identities = 184/687 (26%), Positives = 251/687 (36%), Gaps = 164/687 (23%)

Query: 667  PHLCGDGGFCINFP-GHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSF 725
            P  C +GG C++   G   C C PG+  +      C+  D C++   C            
Sbjct: 32   PEPCANGGTCLSLSLGQGTCQCAPGFLGET-----CQFPDPCQNAQLC------------ 74

Query: 726  KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
                       Q GG+C+ +     G P SP     L  SF CTC  G+     G  C  
Sbjct: 75   -----------QNGGSCQALLPAPLGLPSSPS---PLTPSFLCTCLPGFT----GERC-- 114

Query: 786  VDECEAGDVCDNGICSN-------TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG 838
              + +  D C    CS          G  QC C+ G+        C+  D C       G
Sbjct: 115  --QAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGW----TGEQCQLRDFCSANPCVNG 168

Query: 839  GDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
            G C+ T    +C CP G     G  C+ D++EC QDP  C    +C N  GS+ C+C  G
Sbjct: 169  GVCLATYPQIQCHCPPGFE---GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 225

Query: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957
                Q+   CE    P   + C     +   C  +   + T   C C  G   G  CE+ 
Sbjct: 226  ----QEGPRCELRAGPCPPRGC----SNGGTCQLMPEKDSTFHLCLCPPGF-IGPDCEVN 276

Query: 958  P--CPVYSSAEFHSLCPDG-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNT 1013
            P  C V    +    C DG   YT        G     D+DEC   G   C+  G C N+
Sbjct: 277  PDNC-VSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNS 335

Query: 1014 QPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP--PAEYSPA 1071
               + C C  G  + G   E  ++D+C+  +      C +  G + C C P         
Sbjct: 336  AGSFHCVCVSG--WGGTSCE-ENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHL 392

Query: 1072 QRQCLSPE-----------------------------EMDVDEC----QDPAAC-RPGRC 1097
            +  CLS                                 D+DEC    Q P+ C   G C
Sbjct: 393  EDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSC 452

Query: 1098 VNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDG-MCAGPLAGPA 1156
            +N PGS+ C C     PG +G  C+   +           C SQ    G  C   LA   
Sbjct: 453  LNTPGSFNCLC----PPGYTGSRCEADHNE----------CLSQPCHPGSTCLDLLA--- 495

Query: 1157 LTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNS-----FWDTSPLLLG-----K 1206
             TF  C              CPP   G  C    +E  S       D   LL G      
Sbjct: 496  -TF-HCL-------------CPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICL 540

Query: 1207 PPRDEDSSEEDSDECR---CVS-GRCVPRPGGAVCECPGGFQLDASRARC-VDIDECREL 1261
            P       EED DECR   C + G+C  +PG   C+C  GF+      RC  ++DEC  L
Sbjct: 541  PGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFE----GPRCQTEVDEC--L 594

Query: 1262 NQRGLLCKSERCVNTSGSFRCVCKAGF 1288
            +    +  S  C++  G+F C+C +GF
Sbjct: 595  SDPCPVGAS--CLDLPGAFFCLCPSGF 619



 Score =  107 bits (266), Expect = 1e-22
 Identities = 113/397 (28%), Positives = 146/397 (36%), Gaps = 94/397 (23%)

Query: 588  GECVPGPPDYSCHCNPGYRSHPQHRYCVD-VNECEAEPCGPGRGICMNTGGSYNCHCNRG 646
            G CV   P Y CHC PG+    Q   C D VN CE+ PC  G   CM     Y C C  G
Sbjct: 905  GLCVDSGPSYFCHCPPGF----QGSLCQDHVNPCESRPCQNG-ATCMAQPSGYLCQCAPG 959

Query: 647  YRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY-RLKASRPPVCE-DI 704
            Y       G++C    +  +   C + G C   PG + C C PG+  L+      CE D+
Sbjct: 960  Y------DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLR------CEGDV 1007

Query: 705  DECRDPSSCPDGK--CENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCEN 761
            DEC D    P G   C +   +F C  C PG+  Q    C    +     PC   G CE 
Sbjct: 1008 DECLDQPCHPTGTAACHSLANAFYC-QCLPGHTGQW---CEVEIDPCHSQPCFHGGTCEA 1063

Query: 762  LPGS---FRCTCAQGYAPAPDGRSC------LDVDECEAGDVCDNGICSNTPG-SFQCQC 811
              GS   F C C +G+    +G +C           C  G +C   + S  PG   +C C
Sbjct: 1064 TAGSPLGFICHCPKGF----EGPTCSHRAPSCGFHHCHHGGLC---LPSPKPGFPPRCAC 1116

Query: 812  LSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNG----SYRCLCPQGH-----RLVGG 861
            LSGY    D         C  P+ C+  G C  T G     +RC CP        +  G 
Sbjct: 1117 LSGYG-GPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGA 1175

Query: 862  RKCQ-------------------DIDECS---QDP-SLCLPHGAC--------------- 883
            + C+                   D  +CS    DP   C  H  C               
Sbjct: 1176 KGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDS 1235

Query: 884  -KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919
             + L   Y C      TP  DQ+  +     H +K C
Sbjct: 1236 EECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGC 1272



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 126/515 (24%), Positives = 176/515 (34%), Gaps = 109/515 (21%)

Query: 832  FPAACI-GGDCINTN-GSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNL--- 886
            FP  C  GG C++ + G   C C  G     G  CQ  D C Q+  LC   G+C+ L   
Sbjct: 31   FPEPCANGGTCLSLSLGQGTCQCAPGFL---GETCQFPDPC-QNAQLCQNGGSCQALLPA 86

Query: 887  -----------QGSYVCVCDEGFTPTQDQHGCEEVEQPHH---KKECYLNFDDTVFCDSV 932
                         S++C C  GFT  + Q   E+   P     +  C++       C  +
Sbjct: 87   PLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCM 146

Query: 933  LATNVTQQECCCSLGAGWGDHCEIYPC-------PVYSSAEFHSLCPDGKGYTQDNNIVN 985
                  Q    C L     D C   PC         Y   + H  CP G           
Sbjct: 147  PGWTGEQ----CQLR----DFCSANPCVNGGVCLATYPQIQCH--CPPGFE--------- 187

Query: 986  YGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN 1045
             G    RD++EC        K   C NT   ++C C  G   +G   E +    C     
Sbjct: 188  -GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG--QEGPRCE-LRAGPCPPRGC 243

Query: 1046 CRNGVC----ENTRGGYRCACTPPAEYSPAQRQC-LSPEEMDVDECQDPAACRPGRCVNL 1100
               G C    E     + C C PP    P    C ++P+     +CQ+   C+ G     
Sbjct: 244  SNGGTCQLMPEKDSTFHLCLC-PPGFIGP---DCEVNPDNCVSHQCQNGGTCQDGL---- 295

Query: 1101 PGSYRCECRPPWVPGPSGRDCQ--LPESPAERAPERRD--VCWSQRGE-DGMCAGPLAGP 1155
              +Y C C   W    +G DC   + E   +  P  R+   C +  G    +C     G 
Sbjct: 296  -DTYTCLCPETW----TGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGT 350

Query: 1156 AL--TFDDCCCRQGRGWGAQCRP---CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1210
            +     DDC         A C P   C  R     C      +        + L +P   
Sbjct: 351  SCEENLDDCIA-------ATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHG 403

Query: 1211 EDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCK 1269
            +          +C +    P  G  +C C  G+    S   C  D+DEC    Q    C+
Sbjct: 404  D---------AQCSTN---PLTGSTLCLCQPGY----SGPTCHQDLDECLMAQQGPSPCE 447

Query: 1270 -SERCVNTSGSFRCVCKAGFARSR---PHGACVPQ 1300
                C+NT GSF C+C  G+  SR    H  C+ Q
Sbjct: 448  HGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQ 482



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 93/378 (24%), Positives = 119/378 (31%), Gaps = 72/378 (19%)

Query: 116 PCMNGGQCSS---RNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGAL-STGALPP 171
           PC+NGG C +   + QC CPP F G  C+          G    G S    L S   L P
Sbjct: 164 PCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCP 223

Query: 172 LAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVR 231
           +  EG     +            P P  G        L+P            PP  +   
Sbjct: 224 VGQEGPRCELRAG----------PCPPRGCSNGGTCQLMPEKDSTFHL-CLCPPGFIG-- 270

Query: 232 VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS 291
               P+  V      S   ++    Q  L       P   T      C +D      C +
Sbjct: 271 ----PDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTG---WDCSEDV---DECET 320

Query: 292 NPLPGLTKQEDCCGSIG-------TAWGQSKCHKCPQLQYTGVQKPGPV----RGEVGAD 340
              P       C  S G       + WG + C +           PG       G     
Sbjct: 321 QGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCL 380

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGD--CLNNP--GSYRCVCPPGHSLGPSRTQCIA 396
           CP G   L   H +D+    +   C HGD  C  NP  GS  C+C PG+S GP+   C  
Sbjct: 381 CPPGRTGL-LCHLEDM---CLSQPC-HGDAQCSTNPLTGSTLCLCQPGYS-GPT---CHQ 431

Query: 397 DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQL--CCCSVGKAWGARC---------QRCPT 445
           D  E    C         C+H  +   T     C C  G   G+RC         Q C  
Sbjct: 432 DLDE----CLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCEADHNECLSQPCHP 486

Query: 446 DGT-----AAFKEICPAG 458
             T     A F  +CP G
Sbjct: 487 GSTCLDLLATFHCLCPPG 504



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 79/333 (23%), Positives = 109/333 (32%), Gaps = 56/333 (16%)

Query: 75  CLKG-QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCP-LPCMNGGQC-------SS 125
           C KG  C ++      +  +G+ G   +   G       CP   C NGG C       S+
Sbjct: 205 CPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGP------CPPRGCSNGGTCQLMPEKDST 258

Query: 126 RNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAI 185
            + CLCPP F G  C+V           +G G  + G  +   L P    G   +     
Sbjct: 259 FHLCLCPPGFIGPDCEVNPDNCVSHQCQNG-GTCQDGLDTYTCLCPETWTGWDCSEDVDE 317

Query: 186 YAVQVIADPPGPGEGPPAQHAA----FLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQ 241
              Q    PP    G   Q++A     +   G G  S E      +           S  
Sbjct: 318 CETQ---GPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCA----PGSTC 370

Query: 242 VHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQE 301
           + R+ S +         LL H +      P       C  D      C +NPL G T   
Sbjct: 371 IDRVGSFSCLCPPGRTGLLCHLEDMCLSQP-------CHGDA----QCSTNPLTGSTL-- 417

Query: 302 DCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR---------GEVGADCPQGYKRLNSTH 352
            C    G  +    CH+         Q P P           G     CP GY     + 
Sbjct: 418 -CLCQPG--YSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY---TGSR 471

Query: 353 CQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           C+ D NEC          CL+   ++ C+CPPG
Sbjct: 472 CEADHNECLSQPCHPGSTCLDLLATFHCLCPPG 504



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 73/298 (24%), Positives = 96/298 (32%), Gaps = 66/298 (22%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ------VPAGGAGGGTGGSGPG-------LS 159
           PC+NGG C+       C CPP  TG  CQ      V A    GGT  + PG       + 
Sbjct: 737 PCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMG 796

Query: 160 RTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISA 219
             G    G L P      S A             P GP    P  +       G  Q   
Sbjct: 797 FQGPRCEGKLRP------SCADSPCRNRATCQDSPQGPRCLCPTGYTG-----GSCQTLM 845

Query: 220 EVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRC 279
           ++ A  P                    +S+     PS H L         P    PL  C
Sbjct: 846 DLCAQKPCP-----------------RNSHCLQTGPSFHCL--CLQGWTGPLCNLPLSSC 886

Query: 280 FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQ---KPGPVRG- 335
            +  L +       +  L      C   G ++    CH  P  Q +  Q    P   R  
Sbjct: 887 QKAALSQ----GIDVSSLCHNGGLCVDSGPSY---FCHCPPGFQGSLCQDHVNPCESRPC 939

Query: 336 EVGADC---PQGY-----KRLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           + GA C   P GY        +  +C ++++ C       HG C   PG + C CPPG
Sbjct: 940 QNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPG 997



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 92/412 (22%), Positives = 128/412 (31%), Gaps = 80/412 (19%)

Query: 24  LALLLLLLLLLLGLGGRVEG---GPAGERGAGGGGALARE--RFKVVFAPVICKRTCLKG 78
           L LLLLLLLLL     R  G   G   E  A GG  L+    +     AP     TC   
Sbjct: 6   LLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETC--- 62

Query: 79  QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLP---------------------- 116
           Q  D CQ       + +NG S   L  +   +   P P                      
Sbjct: 63  QFPDPCQNAQ----LCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKL 118

Query: 117 --------CMNGGQC----SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGAL 164
                   C   G+C    S R QC C P +TG  CQ+    +       G  L+    +
Sbjct: 119 EDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQI 178

Query: 165 STGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAF-----LVPLGPGQISA 219
                P    EG +         V      PGP     + H        L P+G      
Sbjct: 179 QCHCPPGF--EGHACERD-----VNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRC 231

Query: 220 EVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRC 279
           E++A P         PP         +    + +     L P   P    P  +     C
Sbjct: 232 ELRAGP--------CPPRGCSNGGTCQLMPEKDSTFHLCLCP---PGFIGPDCEVNPDNC 280

Query: 280 FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSK-CHKCPQLQYTGVQKPGPVRGEVG 338
                     G     GL      C    T W  S+   +C        +  G  +   G
Sbjct: 281 VSHQCQN---GGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAG 337

Query: 339 A---DCPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCPPGHS 386
           +    C  G+     T C++  +  +   C  G  C++  GS+ C+CPPG +
Sbjct: 338 SFHCVCVSGW---GGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRT 386



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 22/61 (36%), Positives = 24/61 (39%), Gaps = 9/61 (14%)

Query: 114  PLPCMNGGQCSSRN-------QCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALST 166
            P PC+  G CS          +C CP    G  CQ P  GA G  G SG G    G    
Sbjct: 1137 PSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKP--GAKGCEGRSGDGACDAGCSGP 1194

Query: 167  G 167
            G
Sbjct: 1195 G 1195



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 14/29 (48%), Positives = 15/29 (51%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PC NGGQC  +     C C P F G  CQ
Sbjct: 559 PCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 116 PCMNGGQCSSRNQ---CLCPPDFTGRFCQVP 143
           PC  G  C        CLCP  FTG+ C+VP
Sbjct: 597 PCPVGASCLDLPGAFFCLCPSGFTGQLCEVP 627



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 27/93 (29%), Positives = 37/93 (39%), Gaps = 18/93 (19%)

Query: 74  TCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQC---SSRNQCL 130
           TC  G C    Q+ S +  +G  G   +   G          PC +GG C    S   C 
Sbjct: 666 TCHHGHC----QRSSCVCDVGWTGPECEAELGGCISA-----PCAHGGTCYPQPSGYNCT 716

Query: 131 CPPDFTGRFC--QVPAGGAG----GGTGGSGPG 157
           CP  +TG  C  ++ A  +G    GG+    PG
Sbjct: 717 CPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPG 749


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  217 bits (552), Expect = 7e-56
 Identities = 224/826 (27%), Positives = 315/826 (38%), Gaps = 177/826 (21%)

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            D+C  N   C HG C+ G   YSC C+PG+      R  +D++EC + PC  G   C+N 
Sbjct: 647  DDCASNP--CIHGICMDGINRYSCVCSPGFTGQ---RCNIDIDECASNPCRKG-ATCING 700

Query: 636  GGSYNCHCNRG-----------------------------YRLHVGAG--GRSC-VDLNE 663
               + C C  G                             Y+    AG  G +C VD NE
Sbjct: 701  VNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNE 760

Query: 664  CAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG 723
            C   + C +GG C N    Y+C C  G++    +     +IDEC        G C +   
Sbjct: 761  CLS-NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQV----NIDECASNPCLNQGTCFDDIS 815

Query: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP--------GSFRCTCAQGYA 775
             + C    P      G  C+ V      +PCSP  CEN           S+ C CA G+ 
Sbjct: 816  GYTCHCVLP----YTGKNCQTVL-----APCSPNPCENAAVCKESPNFESYTCLCAPGW- 865

Query: 776  PAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFP 833
                G+ C +D+DEC +    ++G+C NT GS+ C+C  G+        CE DID+C   
Sbjct: 866  ---QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGF----SGMDCEEDIDDCLAN 918

Query: 834  AACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVC 892
                GG C++   ++ CLC  G     G KCQ D++EC  +P  C   G C +   SY C
Sbjct: 919  PCQNGGSCMDGVNTFSCLCLPGFT---GDKCQTDMNECLSEP--CKNGGTCSDYVNSYTC 973

Query: 893  VCDEGFTPTQDQHGCEEVEQPH-------------HKKECYLNFDDTVFC---------- 929
             C  GF     ++   E  +                   C + F  + FC          
Sbjct: 974  KCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGS-FCLHEINECSSH 1032

Query: 930  ----DSVLATNVTQQECCCSLGAGWGDHCEIY-------PCP-----VYSSAEFHSLCPD 973
                +      +    C C LG   G +C+         PC      V   AE   LCP 
Sbjct: 1033 PCLNEGTCVDGLGTYRCSCPLGYT-GKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPS 1091

Query: 974  G-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQPGYECYCKQGFYYDGNL 1031
            G  G   D   V+  I A R      +    +C+  G C+N    + C C  G  Y G+ 
Sbjct: 1092 GWAGAYCDVPNVSCDIAASRR----GVLVEHLCQHSGVCINAGNTHYCQCPLG--YTGSY 1145

Query: 1032 LECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA 1091
             E   +DEC          C +  GGYRC C P  +            E +VDECQ+   
Sbjct: 1146 CE-EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNC--------EYEVDECQNQPC 1196

Query: 1092 CRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGP 1151
               G C++L   ++C C     PG  G  C+       R P     C +     G C   
Sbjct: 1197 QNGGTCIDLVNHFKCSC----PPGTRGLLCEENIDDCARGPH----CLN----GGQCMDR 1244

Query: 1152 LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDE 1211
            + G +     C C  G   G +C         + C +  S          L + +     
Sbjct: 1245 IGGYS-----CRCLPGFA-GERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTG 1298

Query: 1212 DSSEEDSDEC---RCVS-GRCV---PRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
               E   D C    C++ G C      P G +C CP GF    S ARC     C ++  R
Sbjct: 1299 RHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGF----SGARCQ--SSCGQVKCR 1352

Query: 1265 GLLCKSERCVNTSGSFRCV------CKAGFARS--RPHGACVPQRR 1302
                K E+CV+T+   RC       C++G A S  +  G+C PQR+
Sbjct: 1353 ----KGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQ 1394



 Score =  212 bits (539), Expect = 2e-54
 Identities = 209/782 (26%), Positives = 297/782 (37%), Gaps = 160/782 (20%)

Query: 571  QVTETDECRLNQNICGHGECVPGPPD-YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
            Q + +  C +++     G C     D Y C C  G+      + C   + C + PC  G 
Sbjct: 102  QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTG----KECQWTDACLSHPCANG- 156

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCY 688
              C      ++C C  G+       G+ C  D+NEC  P  C  GG C+N PG Y+C C 
Sbjct: 157  STCTTVANQFSCKCLTGFT------GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCP 210

Query: 689  PGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG--SFKCIACQPGYRSQGGGACRDVN 746
             G+         C+ +     PS C +G    + G  +F+C  C PG+  +G    R+++
Sbjct: 211  QGF-----TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFEC-NCLPGF--EGSTCERNID 262

Query: 747  ECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL-DVDEC-EAGDVCDN-GICSNT 803
            +C      + G C +   ++ C C     P   G+ C  DVDEC    + C N G C+N 
Sbjct: 263  DCPNHRCQNGGVCVDGVNTYNCRC----PPQWTGQFCTEDVDECLLQPNACQNGGTCANR 318

Query: 804  PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK 863
             G + C C++G+  S D    E+ID+C F +   G  CI+   S+ C+CP+G     G  
Sbjct: 319  NGGYGCVCVNGW--SGD-DCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGK---AGLL 372

Query: 864  CQDIDECSQDPSLCLPHGACKN--LQGSYVCVCDEGF-----TPTQDQHGCEEVEQPHHK 916
            C   D C  +P  C     C    L G Y+C C +G+     T   D+          H 
Sbjct: 373  CHLDDACISNP--CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHA 430

Query: 917  KECYLNFDDTVFC-------------------------DSVLATNVTQQECCCSLGAGWG 951
             +C +N D    C                         D+     +    C C  G   G
Sbjct: 431  GKC-VNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFK-G 488

Query: 952  DHCEI-------YPCP-----VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999
             HCE+        PC      V     F  LCP   G+T        G     DID+C  
Sbjct: 489  VHCELEINECQSNPCVNNGQCVDKVNRFQCLCP--PGFT--------GPVCQIDIDDC-- 536

Query: 1000 FGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGY 1058
              S  C  G KC++   GYEC C  GF   G L E  ++D C D   C +G C++    Y
Sbjct: 537  -SSTPCLNGAKCIDHPNGYECQCATGF--TGVLCE-ENIDNC-DPDPCHHGQCQDGIDSY 591

Query: 1059 RCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSG 1118
             C C P    +    Q        +DEC        GRC++L   Y+C C+    PG SG
Sbjct: 592  TCICNPGYMGAICSDQ--------IDECYSSPCLNDGRCIDLVNGYQCNCQ----PGTSG 639

Query: 1119 RDCQLPESPAERAPERRDVCWSQRGE-DGMCAGPLAGPA--LTFDDCC---CRQGRGW-- 1170
             +C++        P    +C         +C+    G    +  D+C    CR+G     
Sbjct: 640  VNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCIN 699

Query: 1171 ---GAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR 1227
               G +C  CP    G H P+  S+ N         L  P               C+ G 
Sbjct: 700  GVNGFRC-ICP---EGPHHPSCYSQVNE-------CLSNP---------------CIHGN 733

Query: 1228 CVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKA 1286
            C     G  C C  G+        C VD +EC              C N    +RC CK 
Sbjct: 734  CTGGLSGYKCLCDAGW----VGINCEVDKNECLS----NPCQNGGTCDNLVNGYRCTCKK 785

Query: 1287 GF 1288
            GF
Sbjct: 786  GF 787



 Score =  204 bits (519), Expect = 4e-52
 Identities = 201/815 (24%), Positives = 308/815 (37%), Gaps = 182/815 (22%)

Query: 574  ETDECRL-NQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGI 631
            + DEC + N N C H G+CV     + C C  GY      R  +D+NEC ++PC      
Sbjct: 415  DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGP---RCEMDINECHSDPC-QNDAT 470

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPG 690
            C++  G + C C  G++      G  C +++NEC + + C + G C++    ++C C PG
Sbjct: 471  CLDKIGGFTCLCMPGFK------GVHCELEINEC-QSNPCVNNGQCVDKVNRFQCLCPPG 523

Query: 691  YRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
            +       PVC+ DID+C         KC + P  ++C  C  G+    G  C +  +  
Sbjct: 524  FT-----GPVCQIDIDDCSSTPCLNGAKCIDHPNGYEC-QCATGFT---GVLCEENIDNC 574

Query: 750  EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGICSNTPGSFQ 808
            +  PC  G C++   S+ C C  GY     G  C D +DEC +    ++G C +    +Q
Sbjct: 575  DPDPCHHGQCQDGIDSYTCICNPGYM----GAICSDQIDECYSSPCLNDGRCIDLVNGYQ 630

Query: 809  CQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-D 866
            C C  G        +CE + D+C     CI G C++    Y C+C  G     G++C  D
Sbjct: 631  CNCQPG----TSGVNCEINFDDCA-SNPCIHGICMDGINRYSCVCSPGFT---GQRCNID 682

Query: 867  IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT 926
            IDEC+ +P  C     C N    + C+C EG               PHH   CY   ++ 
Sbjct: 683  IDECASNP--CRKGATCINGVNGFRCICPEG---------------PHHPS-CYSQVNEC 724

Query: 927  VFCDSVLAT---NVTQQECCCSLGAGW-GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNN 982
            +    +       ++  +C C   AGW G +CE+      S+       P   G T DN 
Sbjct: 725  LSNPCIHGNCTGGLSGYKCLCD--AGWVGINCEVDKNECLSN-------PCQNGGTCDNL 775

Query: 983  IVNY---------GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC------------ 1021
            +  Y         G     +IDEC    +    +G C +   GY C+C            
Sbjct: 776  VNGYRCTCKKGFKGYNCQVNIDECA--SNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTV 833

Query: 1022 ---------------KQGFYYDGNLLEC----------VDVDECLDESNCRNGVCENTRG 1056
                           K+   ++     C          +D+DEC+ +    +G+C NT+G
Sbjct: 834  LAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQG 893

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGP 1116
             Y C C P      +   C    E D+D+C        G C++   ++ C C    +PG 
Sbjct: 894  SYMCECPP----GFSGMDC----EEDIDDCLANPCQNGGSCMDGVNTFSCLC----LPGF 941

Query: 1117 SGRDCQLPESPAERAPERRD----------VCWSQRGEDGM-CAGPL--AGPALTFDDCC 1163
            +G  CQ   +     P +             C  Q G DG+ C   +     +  F+   
Sbjct: 942  TGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGT 1001

Query: 1164 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1223
            C  G      C  CP    GS C    +E +S           P  +E +  +     RC
Sbjct: 1002 CVDGIN-SFSCL-CPVGFTGSFCLHEINECSS----------HPCLNEGTCVDGLGTYRC 1049

Query: 1224 V------------------------SGRCVPRPGGAVCECPGGF---QLDASRARCVDID 1256
                                      G CV +   + C CP G+     D     C    
Sbjct: 1050 SCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAA 1109

Query: 1257 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARS 1291
              R +    L   S  C+N   +  C C  G+  S
Sbjct: 1110 SRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGS 1144



 Score =  194 bits (492), Expect = 6e-49
 Identities = 198/746 (26%), Positives = 270/746 (36%), Gaps = 137/746 (18%)

Query: 586  GHGECVPGPPDYSCHCNPGYRSHPQH---RYCVDVNECEAEPCGPGRGICMNTG--GSYN 640
            G+  CV      + H   GY   P+     YC   + CE   C  G G C+     G   
Sbjct: 31   GYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNG-GTCVAQAMLGKAT 89

Query: 641  CHCNRGYRLHVGAGGRSCV--DLNECAKPHLCGDGGFCINFPGH-YKCNCYPGYRLKASR 697
            C C  G+       G  C     + C     C +GG C       Y+C C  G+  K   
Sbjct: 90   CRCASGFT------GEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE-- 141

Query: 698  PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVNECAEGSPCSP 756
               C+  D C          C      F C  C  G+  Q    C  DVNEC     C  
Sbjct: 142  ---CQWTDACLSHPCANGSTCTTVANQFSC-KCLTGFTGQ---KCETDVNECDIPGHCQH 194

Query: 757  GW-CENLPGSFRCTCAQGYAPAPDGRSCLDVD-ECEAGDVCDNGICSNTPG-SFQCQCLS 813
            G  C NLPGS++C C QG+     G+ C  +   C      + G C  T   +F+C CL 
Sbjct: 195  GGTCLNLPGSYQCQCPQGFT----GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 250

Query: 814  GYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQ 872
            G+    + S CE +ID+C       GG C++   +Y C CP   +  G    +D+DEC  
Sbjct: 251  GF----EGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPP--QWTGQFCTEDVDECLL 304

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCD-- 930
             P+ C   G C N  G Y CVC  G++                  +C  N DD  F    
Sbjct: 305  QPNACQNGGTCANRNGGYGCVCVNGWSGD----------------DCSENIDDCAFASCT 348

Query: 931  --SVLATNVTQQECCCSLGAGW-----GDHCEIYPCPVYSSAEFHSL-----CPDGKGYT 978
              S     V    C C  G         D C   PC   +  + + L     C   +GY 
Sbjct: 349  PGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK 408

Query: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQPGYECYCKQGFYYDGNLLECVDV 1037
                    G     D+DEC +  S  C+  GKCVNT   + C C +G  Y G   E +D+
Sbjct: 409  --------GADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKG--YAGPRCE-MDI 457

Query: 1038 DECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRC 1097
            +EC  +    +  C +  GG+ C C P  +            E++++ECQ       G+C
Sbjct: 458  NECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHC--------ELEINECQSNPCVNNGQC 509

Query: 1098 VNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDV-CWSQ-RGEDGMCAGPLAGP 1155
            V+    ++C C PP   GP    CQ+        P      C     G +  CA    G 
Sbjct: 510  VDKVNRFQCLC-PPGFTGPV---CQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGV 565

Query: 1156 AL--TFDDCC---CRQGR---GWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKP 1207
                  D+C    C  G+   G  +    C P   G+ C     E  S    SP L    
Sbjct: 566  LCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYS----SPCLN--- 618

Query: 1208 PRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGL 1266
                              GRC+    G  C C  G     S   C ++ D+C        
Sbjct: 619  -----------------DGRCIDLVNGYQCNCQPG----TSGVNCEINFDDCASNP---- 653

Query: 1267 LCKSERCVNTSGSFRCVCKAGFARSR 1292
             C    C++    + CVC  GF   R
Sbjct: 654  -CIHGICMDGINRYSCVCSPGFTGQR 678



 Score =  176 bits (447), Expect = 1e-43
 Identities = 234/956 (24%), Positives = 343/956 (35%), Gaps = 233/956 (24%)

Query: 340  DCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHS---LGPSRTQCI 395
            +C  G   +N   C+ + ++CA    C HG C++    Y CVC PG +         +C 
Sbjct: 632  NCQPGTSGVN---CEINFDDCAS-NPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECA 687

Query: 396  ADKPEEKSLC------FRLVSPE----------------HQCQH-PLTTRLTRQLCCCSV 432
            ++   + + C      FR + PE                + C H   T  L+   C C  
Sbjct: 688  SNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDA 747

Query: 433  GKAW-GARCQ---------RCPTDGTA-----AFKEICPAG-KGYHILTS---------- 466
            G  W G  C+          C   GT       ++  C  G KGY+   +          
Sbjct: 748  G--WVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCL 805

Query: 467  HQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQ 526
            +Q       S ++         K  Q   +P    P E+      V  +SP  E  +   
Sbjct: 806  NQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENA----AVCKESPNFESYTCLC 861

Query: 527  SHPTATTTPARPYPELISRP------SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRL 580
            +             E IS+P         T   ++ + PP  S ++       + D+C  
Sbjct: 862  APGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCE----EDIDDCLA 917

Query: 581  NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640
            N    G G C+ G   +SC C PG+      +   D+NEC +EPC  G G C +   SY 
Sbjct: 918  NPCQNG-GSCMDGVNTFSCLCLPGFTG---DKCQTDMNECLSEPCKNG-GTCSDYVNSYT 972

Query: 641  CHCNRGYRLHVGAGGRSCV-DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPP 699
            C C  G+       G  C  ++NEC +   C +GG C++    + C C  G+    +   
Sbjct: 973  CKCQAGF------DGVHCENNINECTESS-CFNGGTCVDGINSFSCLCPVGF----TGSF 1021

Query: 700  VCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQ---------GGGACRDVNECAE 750
               +I+EC       +G C +  G+++C +C  GY  +             C++   C +
Sbjct: 1022 CLHEINECSSHPCLNEGTCVDGLGTYRC-SCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQ 1080

Query: 751  GSP-----CSPGW--------------------------------CENLPGSFRCTCAQG 773
                    C  GW                                C N   +  C C  G
Sbjct: 1081 KKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLG 1140

Query: 774  YAPAPDGRSCLD-VDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDEC 830
            Y     G  C + +DEC A + C +G  CS+  G ++C+C+ GY       +CE ++DEC
Sbjct: 1141 YT----GSYCEEQLDEC-ASNPCQHGATCSDFIGGYRCECVPGY----QGVNCEYEVDEC 1191

Query: 831  DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQD-IDECSQDPSLCLPHGACKNLQGS 889
                   GG CI+    ++C CP G R   G  C++ ID+C++ P  CL  G C +  G 
Sbjct: 1192 QNQPCQNGGTCIDLVNHFKCSCPPGTR---GLLCEENIDDCARGPH-CLNGGQCMDRIGG 1247

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949
            Y C C  GF   +    CE         EC  N   +    S+    +T    C    A 
Sbjct: 1248 YSCRCLPGFAGER----CE-----GDINECLSNPCSSE--GSLDCIQLTNDYLCVCRSAF 1296

Query: 950  WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK 1009
             G HCE           F  +CP               +P       C+  G+  C    
Sbjct: 1297 TGRHCE----------TFVDVCPQ--------------MP-------CLNGGT--CAVAS 1323

Query: 1010 CVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPAEY 1068
              N   G+ C C  GF        C  V        CR G  C +T  G RC C  P + 
Sbjct: 1324 --NMPDGFICRCPPGFSGARCQSSCGQV-------KCRKGEQCVHTASGPRCFCPSPRD- 1373

Query: 1069 SPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPA 1128
               +  C S        CQ   +C P R    P  Y C+C PP+    SG  C+L  +P 
Sbjct: 1374 --CESGCAS------SPCQHGGSCHPQR---QPPYYSCQCAPPF----SGSRCELYTAPP 1418

Query: 1129 ERAPERRDVCWSQ----RGEDGMCAGPLAGPALTFD--DCCCRQGRGWGAQCRPCP 1178
               P     C SQ    +  DG+C       A  +D  DC       W     P P
Sbjct: 1419 STPPA---TCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLP 1471



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 20/31 (64%), Positives = 24/31 (77%), Gaps = 1/31 (3%)

Query: 355 DINECAMPGVCRHGD-CLNNPGSYRCVCPPG 384
           D+NEC +PG C+HG  CLN PGSY+C CP G
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQG 212



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 10/81 (12%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAM--PGVCRH-GDCLNNPGSYRCVCPPGHSLG 388
           P+ G+    CPQGYK  + T  +D++ECAM     C H G C+N  G++ C C  G++ G
Sbjct: 394 PLNGQYICTCPQGYKGADCT--EDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA-G 450

Query: 389 P----SRTQCIADKPEEKSLC 405
           P       +C +D  +  + C
Sbjct: 451 PRCEMDINECHSDPCQNDATC 471



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 33/89 (37%), Positives = 40/89 (44%), Gaps = 22/89 (24%)

Query: 75  CLKGQCRDSCQQGSN----------MTLIGENGHSTDTLTGSGFRVVVCPL--------P 116
           CLKG     C+   N           T + + G  T  L   GF+ V C L        P
Sbjct: 444 CLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFT-CLCMPGFKGVHCELEINECQSNP 502

Query: 117 CMNGGQCS---SRNQCLCPPDFTGRFCQV 142
           C+N GQC    +R QCLCPP FTG  CQ+
Sbjct: 503 CVNNGQCVDKVNRFQCLCPPGFTGPVCQI 531



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 7/43 (16%)

Query: 110  VVVCP-LPCMNGGQCSSRNQ------CLCPPDFTGRFCQVPAG 145
            V VCP +PC+NGG C+  +       C CPP F+G  CQ   G
Sbjct: 1305 VDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCG 1347



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 5/50 (10%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGP 389
           C  G+K     HC+ +INEC       +G C++    ++C+CPPG + GP
Sbjct: 482 CMPGFK---GVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFT-GP 527



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 36/126 (28%), Positives = 49/126 (38%), Gaps = 33/126 (26%)

Query: 354 QDINECAM-PGVCRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP 411
           +D++EC + P  C++G  C N  G Y CVC  G S G   ++ I D        F   +P
Sbjct: 297 EDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWS-GDDCSENIDD------CAFASCTP 349

Query: 412 EHQCQHPLTTRLTRQLCCCSVGKAW----------------GARCQRCPTDGTAAFKEIC 455
              C      R+    C C  GKA                 GA C   P +G    + IC
Sbjct: 350 GSTC----IDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNG----QYIC 401

Query: 456 PAGKGY 461
              +GY
Sbjct: 402 TCPQGY 407



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 29/131 (22%), Positives = 55/131 (41%), Gaps = 12/131 (9%)

Query: 334  RGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT- 392
            +G    +CP G+  ++    +DI++C        G C++   ++ C+C PG +    +T 
Sbjct: 892  QGSYMCECPPGFSGMDCE--EDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTD 949

Query: 393  --QCIADKPEEKSLCFRLV-SPEHQCQHPLT-TRLTRQLCCCSVGKAW-GARCQRCPTDG 447
              +C+++  +    C   V S   +CQ           +  C+    + G  C     DG
Sbjct: 950  MNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTC----VDG 1005

Query: 448  TAAFKEICPAG 458
              +F  +CP G
Sbjct: 1006 INSFSCLCPVG 1016



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 17/81 (20%)

Query: 68   PVICKRTCLKG--QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQC-- 123
            P + + TC+ G    R SC        +G  G +  TL     R      PC N G C  
Sbjct: 1033 PCLNEGTCVDGLGTYRCSCP-------LGYTGKNCQTLVNLCSRS-----PCKNKGTCVQ 1080

Query: 124  -SSRNQCLCPPDFTGRFCQVP 143
              + +QCLCP  + G +C VP
Sbjct: 1081 KKAESQCLCPSGWAGAYCDVP 1101



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 29/84 (34%), Positives = 38/84 (45%), Gaps = 17/84 (20%)

Query: 84  CQQGSNMTLIGENGHSTDTLTG-SGFR----VVVCPLP--CMNGGQCSS---RNQCLCPP 133
           C  GS  T +  N  S   LTG +G +    V  C +P  C +GG C +     QC CP 
Sbjct: 153 CANGSTCTTVA-NQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQ 211

Query: 134 DFTGRFCQ------VPAGGAGGGT 151
            FTG++C        P+    GGT
Sbjct: 212 GFTGQYCDSLYVPCAPSPCVNGGT 235



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 8/56 (14%)

Query: 338 GADC---PQGYKRLNSTH-----CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGH 385
           GA C   P GY+   +T      C++  +   P  C HG C +   SY C+C PG+
Sbjct: 544 GAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGY 599



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 29/86 (33%), Positives = 32/86 (37%), Gaps = 20/86 (23%)

Query: 75   CLKGQCRDSCQQGSNMTLIG--ENGHSTDTLTGS-------GFRVVVCP--------LPC 117
            CL G   D CQ   N  L    +NG +      S       GF  V C           C
Sbjct: 937  CLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSC 996

Query: 118  MNGGQCS---SRNQCLCPPDFTGRFC 140
             NGG C    +   CLCP  FTG FC
Sbjct: 997  FNGGTCVDGINSFSCLCPVGFTGSFC 1022



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 5/65 (7%)

Query: 116  PCMNGGQC---SSRNQCLCPPDFTGRFCQVPAGGAGGGTG--GSGPGLSRTGALSTGALP 170
            PC NGG C    +  +C CPP   G  C+        G      G  + R G  S   LP
Sbjct: 1195 PCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLP 1254

Query: 171  PLAPE 175
              A E
Sbjct: 1255 GFAGE 1259



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 15/29 (51%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           PC NGG C    +   CLC P FTG  CQ
Sbjct: 919 PCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 14/50 (28%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            G    +C  GY+ +N  +  +++EC        G C++    ++C CPPG
Sbjct: 1169 GGYRCECVPGYQGVNCEY--EVDECQNQPCQNGGTCIDLVNHFKCSCPPG 1216



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 3/27 (11%)

Query: 117 CMNGGQCS---SRNQCLCPPDFTGRFC 140
           C NGG C    +   C CPP +TG+FC
Sbjct: 269 CQNGGVCVDGVNTYNCRCPPQWTGQFC 295



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 18/74 (24%)

Query: 74  TCLK--GQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRN---- 127
           TCL   G  +  C QG         G   D+L      V   P PC+NGG C        
Sbjct: 197 TCLNLPGSYQCQCPQGFT-------GQYCDSLY-----VPCAPSPCVNGGTCRQTGDFTF 244

Query: 128 QCLCPPDFTGRFCQ 141
           +C C P F G  C+
Sbjct: 245 ECNCLPGFEGSTCE 258



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 15/30 (50%), Positives = 19/30 (63%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCS--SRN--QCLCPPDFTGRFCQ 141
           PC+NGG C   SR+  +C C   FTG+ CQ
Sbjct: 114 PCLNGGTCHMLSRDTYECTCQVGFTGKECQ 143



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 32/127 (25%), Positives = 47/127 (37%), Gaps = 19/127 (14%)

Query: 341 CPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC----- 394
           C  GY       C D I+EC        G C++    Y+C C P    G S   C     
Sbjct: 595 CNPGYM---GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP----GTSGVNCEINFD 647

Query: 395 -IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT--DGTAAF 451
             A  P    +C   ++  + C    +   T Q C   + +     C++  T  +G   F
Sbjct: 648 DCASNPCIHGICMDGIN-RYSC--VCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGF 704

Query: 452 KEICPAG 458
           + ICP G
Sbjct: 705 RCICPEG 711



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 13/29 (44%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PCMN G C +      C CPP F+G  C+
Sbjct: 881 PCMNHGLCHNTQGSYMCECPPGFSGMDCE 909



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 13/28 (46%), Positives = 15/28 (53%), Gaps = 3/28 (10%)

Query: 117  CMNGGQCSSR---NQCLCPPDFTGRFCQ 141
            C+NGGQC  R     C C P F G  C+
Sbjct: 1235 CLNGGQCMDRIGGYSCRCLPGFAGERCE 1262



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 12/30 (40%), Positives = 15/30 (50%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQC----SSRNQCLCPPDFTGRFCQ 141
           PC+N G C    +    C CP  F G +CQ
Sbjct: 34  PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ 63



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 18/73 (24%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS--LGPSRT 392
           G  G  C  G+   + +  ++I++CA         C++   S+ C+CP G +  L     
Sbjct: 320 GGYGCVCVNGWSGDDCS--ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDD 377

Query: 393 QCIADKPEEKSLC 405
            CI++   + +LC
Sbjct: 378 ACISNPCHKGALC 390



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 14/45 (31%), Positives = 21/45 (46%), Gaps = 4/45 (8%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           CP G+       CQ DI++C+         C+++P  Y C C  G
Sbjct: 520 CPPGF---TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATG 561



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 5/32 (15%)

Query: 116  PCMNGGQCSSRNQ-----CLCPPDFTGRFCQV 142
            PC +GG C  + Q     C C P F+G  C++
Sbjct: 1382 PCQHGGSCHPQRQPPYYSCQCAPPFSGSRCEL 1413


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  217 bits (552), Expect = 7e-56
 Identities = 169/554 (30%), Positives = 251/554 (45%), Gaps = 88/554 (15%)

Query: 563  SAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA 622
            S+VE    Q+ ET   +++ +I           D S  C  G+       +C D +EC A
Sbjct: 5062 SSVESDYNQIEETLGFKIHASI--------SKGDRSNQCPSGFTLDSVGPFCADEDECAA 5113

Query: 623  -EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFP 680
              PC      C N  G+Y C C +G  L + A GR+C D++ECA   H C  G  C N  
Sbjct: 5114 GNPCSHS---CHNAMGTYYCSCPKG--LTIAADGRTCQDIDECALGRHTCHAGQDCDNTI 5168

Query: 681  GHYKC--NCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG 738
            G Y+C   C  G+R + S    C+DI+EC++ S C   +C N  GSF C  C+PGY+ +G
Sbjct: 5169 GSYRCVVRCGSGFR-RTSDGLSCQDINECQESSPCHQ-RCFNAIGSFHC-GCEPGYQLKG 5225

Query: 739  GGACRDVNECAEGSPCSPGW-CENLPGSFRCT--CAQGYAPAPDGRSCLDVDECEAGD-V 794
               C DVNEC + + C P   C+N  G ++C   C  G   A +G +C+D+DEC+ G   
Sbjct: 5226 R-KCMDVNECRQ-NVCRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQ 5282

Query: 795  CD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
            C  N IC NT GS++C C  GY        C DI+EC+         C NT GS++C+CP
Sbjct: 5283 CRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICP 5342

Query: 854  QGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
             G  L+G G+ C  ++         LP     N    Y       F+P ++ +      Q
Sbjct: 5343 PGQHLLGDGKSCAGLER--------LP-----NYGTQYSSYNLARFSPVRNNY----QPQ 5385

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
             H+++  +L    + + +S  + + T++                              CP
Sbjct: 5386 QHYRQYSHLYSSYSEYRNSRTSLSRTRR-------------------------TIRKTCP 5420

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL 1032
            +G   + D  +         DIDEC    ++ C+  +C NT   Y+C C  G+    N  
Sbjct: 5421 EGSEASHDTCV---------DIDECE--NTDACQH-ECKNTFGSYQCICPPGYQLTHNGK 5468

Query: 1033 ECVDVDECLDES-NC-RNGVCENTRGGYRC---ACTPPAEYSPAQRQCLSPEEMDVDECQ 1087
             C D+DECL+++ +C  N +C N RG Y+C    C P  +  P    CL     +  EC 
Sbjct: 5469 TCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECA 5528

Query: 1088 DPAACRPGRCVNLP 1101
                    + V+LP
Sbjct: 5529 LSPYALEYKLVSLP 5542



 Score =  158 bits (400), Expect = 3e-38
 Identities = 147/523 (28%), Positives = 200/523 (38%), Gaps = 112/523 (21%)

Query: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG 860
            S + G    QC SG+ L      C D DEC     C    C N  G+Y C CP+G  +  
Sbjct: 5082 SISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNPC-SHSCHNAMGTYYCSCPKGLTIAA 5140

Query: 861  -GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV--CDEGFTPTQDQHGCEEVEQPHHKK 917
             GR CQDIDEC+     C     C N  GSY CV  C  GF  T D   C+++ +     
Sbjct: 5141 DGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESS 5200

Query: 918  ECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGY 977
             C+                   Q C  ++G+                  FH  C  G   
Sbjct: 5201 PCH-------------------QRCFNAIGS------------------FHCGCEPG--- 5220

Query: 978  TQDNNIVNYGIPAHR--DIDECMLFGSEICKEGK-CVNTQPGYECY--CKQGFYYDGNLL 1032
                    Y +   +  D++EC      +C+  + C NT+ GY+C   C  G     N  
Sbjct: 5221 --------YQLKGRKCMDVNECR---QNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT 5269

Query: 1033 ECVDVDECLDESN-CR-NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA 1090
             C+D+DEC D ++ CR N +CENTRG YRC C          R C     MD++EC+   
Sbjct: 5270 -CIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPC-----MDINECEQVP 5323

Query: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCA- 1149
                 +C N PGS++C C P       G+ C    +  ER P       +Q     +   
Sbjct: 5324 KPCAHQCSNTPGSFKCICPPGQHLLGDGKSC----AGLERLPN----YGTQYSSYNLARF 5375

Query: 1150 GPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE----SNSFWDTSPLLLG 1205
             P+                      +P       SH  +S SE      S   T   +  
Sbjct: 5376 SPVRN------------------NYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRK 5417

Query: 1206 KPPRDEDSSEE---DSDECR---CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1259
              P   ++S +   D DEC         C    G   C CP G+QL  +   C DIDEC 
Sbjct: 5418 TCPEGSEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECL 5477

Query: 1260 ELNQRGLLCKSER-CVNTSGSFRCV---CKAGFARSRPHGACV 1298
            E N   + C   R C N  GS++C+   C   + R    G C+
Sbjct: 5478 EQN---VHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL 5517



 Score =  148 bits (373), Expect = 4e-35
 Identities = 118/358 (32%), Positives = 154/358 (43%), Gaps = 71/358 (19%)

Query: 587  HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCH--CN 644
            H  C      + C C PGY+   + R C+DVNEC    C P +  C NT G Y C   C 
Sbjct: 5203 HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQH-CKNTRGGYKCIDLCP 5259

Query: 645  RGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCED 703
             G      A   +C+D++EC    H C     C N  G Y+C C  GYR +    P C D
Sbjct: 5260 NGM---TKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRP-CMD 5315

Query: 704  IDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNEC------------A 749
            I+EC   P  C   +C N PGSFKCI C PG    G G +C  +               A
Sbjct: 5316 INECEQVPKPCAH-QCSNTPGSFKCI-CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLA 5373

Query: 750  EGSPCSPGW--------CENLPGSF-----------------RCTCAQGYAPAPDGRSCL 784
              SP    +          +L  S+                 R TC +G   + D  +C+
Sbjct: 5374 RFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCV 5431

Query: 785  DVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD--CI 842
            D+DECE  D C +  C NT GS+QC C  GY L+ +   C+DIDEC       G +  C 
Sbjct: 5432 DIDECENTDACQHE-CKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCF 5490

Query: 843  NTNGSYRCL---CPQGHRL--VGG---RKCQDID-ECSQDP------SLCLPHGACKN 885
            N  GSY+C+   CP  ++   V G   + C   D EC+  P       + LP G   N
Sbjct: 5491 NMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATN 5548



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 90/340 (26%), Positives = 133/340 (39%), Gaps = 57/340 (16%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
            C  G++R +    CQDINEC     C H  C N  GS+ C C PG+ L     +C+    
Sbjct: 5177 CGSGFRRTSDGLSCQDINECQESSPC-HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNE 5233

Query: 400  EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC---QRCPTDGT--AAFKEI 454
              +++C     P+  C++         LC   + KA    C     C  DGT    + +I
Sbjct: 5234 CRQNVC----RPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDEC-KDGTHQCRYNQI 5288

Query: 455  CPAGKGYHILTSHQTLTIQGESDFSLFLHP-DGPPKP--QQLPESPSQ----APPPE--- 504
            C   +G +     +    QG     + ++  +  PKP   Q   +P       PP +   
Sbjct: 5289 CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLL 5348

Query: 505  -DTEEERG---------------VTTDSPVSEERSVQQ-----SHPTATTTPARPYPELI 543
             D +   G               +   SPV      QQ     SH  ++ +  R     +
Sbjct: 5349 GDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSL 5408

Query: 544  SRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNP 603
            SR +  T+R   P+        E +     + DEC  N + C H EC      Y C C P
Sbjct: 5409 SR-TRRTIRKTCPE------GSEASHDTCVDIDECE-NTDACQH-ECKNTFGSYQCICPP 5459

Query: 604  GYRSHPQHRYCVDVNEC--EAEPCGPGRGICMNTGGSYNC 641
            GY+     + C D++EC  +   CGP R +C N  GSY C
Sbjct: 5460 GYQLTHNGKTCQDIDECLEQNVHCGPNR-MCFNMRGSYQC 5498



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 18/104 (17%)

Query: 296  GLTKQEDCCGSIGTAWGQSKC----HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-S 350
            G+TK E+     GT     +C    H+C   +Y  + +    RG     CP+GY+     
Sbjct: 5261 GMTKAEN-----GTCIDIDECKDGTHQC---RYNQICEN--TRGSYRCVCPRGYRSQGVG 5310

Query: 351  THCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPG-HSLGPSRT 392
              C DINEC  +P  C H  C N PGS++C+CPPG H LG  ++
Sbjct: 5311 RPCMDINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKS 5353



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 2/61 (3%)

Query: 334  RGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            R  +   CP+G +  + T C DI+EC     C+H +C N  GSY+C+CPPG+ L  +   
Sbjct: 5412 RRTIRKTCPEGSEASHDT-CVDIDECENTDACQH-ECKNTFGSYQCICPPGYQLTHNGKT 5469

Query: 394  C 394
            C
Sbjct: 5470 C 5470



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 26/71 (36%), Positives = 33/71 (46%), Gaps = 6/71 (8%)

Query: 341  CPQGYKRL-NSTHCQDINECAMPGV-CRHGD-CLNNPGSYRCV---CPPGHSLGPSRTQC 394
            CP GY+   N   CQDI+EC    V C     C N  GSY+C+   CPP +   P    C
Sbjct: 5457 CPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFC 5516

Query: 395  IADKPEEKSLC 405
            + + P     C
Sbjct: 5517 LKNCPPNDLEC 5527



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 22/63 (34%), Positives = 30/63 (47%), Gaps = 4/63 (6%)

Query: 334  RGEVGADCPQGYKRLNST--HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            +G+    CP G+  L+S    C D +ECA    C H  C N  G+Y C CP G ++    
Sbjct: 5085 KGDRSNQCPSGFT-LDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADG 5142

Query: 392  TQC 394
              C
Sbjct: 5143 RTC 5145


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  209 bits (533), Expect = 1e-53
 Identities = 132/338 (39%), Positives = 173/338 (51%), Gaps = 35/338 (10%)

Query: 599  CHCNPGYRSHPQHRYCVDVNEC--EAEPCGPGRGICMNTGGSYNCH----CNRGYRLHVG 652
            C C PGY        C D+NEC  +   C  G   C+NT GS++C+    C  GY L  G
Sbjct: 702  CSCFPGYAIMADGVSCEDINECVTDLHTCSRGEH-CVNTLGSFHCYKALTCEPGYALKDG 760

Query: 653  AGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKC----NCYPGYRLKASRPPVCEDIDEC 707
                 C D++ECA   H C  G  C N  G + C     C  G+         C DI+EC
Sbjct: 761  ----ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN--CVDINEC 814

Query: 708  RDPSS-C-PDGKCENKPGSFKC----IACQPGYR-SQGGGACRDVNECAEG-SPCSPGW- 758
               S  C P   C N  GS+ C    + C  GY  S  G  C DVNEC  G   C  G  
Sbjct: 815  TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 874

Query: 759  CENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYH 816
            C NLPGS+RC C  G+     GR C+DV+EC A  G +C +  C NT GS++C C SG+ 
Sbjct: 875  CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFL 933

Query: 817  LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPS 875
            L+ D   CED++EC+  A     +C N  GSY+C C QG++L   G  C DIDEC+Q   
Sbjct: 934  LAADGKRCEDVNECE--AQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAG 991

Query: 876  LCLPHGACKNLQGSYVCVC-DEGFTPTQDQHGCEEVEQ 912
            + L    C N+ GSY C C ++G+T T +   C++V++
Sbjct: 992  I-LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1028



 Score =  201 bits (511), Expect = 4e-51
 Identities = 133/345 (38%), Positives = 173/345 (50%), Gaps = 36/345 (10%)

Query: 574  ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECE--AEPCG 626
            + +EC  + + C  GE CV     + C+    C PGY        C DV+EC      C 
Sbjct: 719  DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQ 776

Query: 627  PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPG 681
            PG  +C NT GS+ C     C  G+ L    G  +CVD+NEC      C  G  CIN  G
Sbjct: 777  PGF-LCQNTKGSFYCQARQRCMDGF-LQDPEG--NCVDINECTSLSEPCRPGFSCINTVG 832

Query: 682  HYKCN-----CYPGYRLKASRPPVCEDIDECRDP-SSCPDGK-CENKPGSFKCIACQPGY 734
             Y C      C  GY         C D++EC      C +G+ C N PGS++C  C+ G+
Sbjct: 833  SYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRCGEGQVCHNLPGSYRC-DCKAGF 890

Query: 735  -RSQGGGACRDVNEC--AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
             R   G  C DVNEC  + G  C    CEN  GS+RC+CA G+  A DG+ C DV+ECEA
Sbjct: 891  QRDAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRCEDVNECEA 949

Query: 792  GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNGSYRC 850
                    C+N  GS+QC C  GY L+ D   C DIDEC   A  +    C+N  GSY+C
Sbjct: 950  QRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQC 1007

Query: 851  LCP-QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             CP QG+ +   GR C+D+DEC+     C     C N+QGS+ C+
Sbjct: 1008 ACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1052



 Score =  189 bits (480), Expect = 1e-47
 Identities = 165/514 (32%), Positives = 212/514 (41%), Gaps = 71/514 (13%)

Query: 616  DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGF 675
            D +EC   P    + +C+NT GSY+C C  G+ L     GR+C       +P    +   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ--DDGRTCRPEGHPPQPEAPQEPAL 661

Query: 676  CINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR 735
               F      N  P   L   +P  C+D   C+         C    GS  C +C PGY 
Sbjct: 662  KSEF-SQVASNTIP---LPLPQPNTCKDNGPCKQV-------CSTVGGSAIC-SCFPGYA 709

Query: 736  SQGGG-ACRDVNECAEG-SPCSPG-WCENLPGSFRC----TCAQGYAPAPDGRSCLDVDE 788
                G +C D+NEC      CS G  C N  GSF C    TC  GYA   DG  C DVDE
Sbjct: 710  IMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA-LKDGE-CEDVDE 767

Query: 789  CEAGD-VCDNG-ICSNTPGSFQCQ----CLSGYHLSRDRSHCEDIDEC-DFPAACIGG-D 840
            C  G   C  G +C NT GSF CQ    C+ G+ L     +C DI+EC      C  G  
Sbjct: 768  CAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFS 826

Query: 841  CINTNGSYRC-----LCPQG-HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC 894
            CINT GSY C     +C +G H    G KC D++EC      C     C NL GSY C C
Sbjct: 827  CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 886

Query: 895  DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG---AGWG 951
              GF       GC +V       EC+ +      C       +    C C+ G   A  G
Sbjct: 887  KAGFQRDAFGRGCIDV------NECWAS--PGRLCQHTCENTLGSYRCSCASGFLLAADG 938

Query: 952  DHCE-IYPCPVYSSAE--------FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGS 1002
              CE +  C     ++        +   C  G    +D +          DIDEC   G+
Sbjct: 939  KRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCT-------DIDECAQ-GA 990

Query: 1003 EICKEGKCVNTQPGYECYC-KQGFYYDGNLLECVDVDEC-LDESNCRNG-VCENTRGGYR 1059
             I    +C+N    Y+C C +QG+    N   C DVDEC L   NC     C N +G +R
Sbjct: 991  GILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFR 1050

Query: 1060 CAC--TPPAEYSPAQRQCLSPEEMDVDECQDPAA 1091
            C     PP     ++ +C      D  ECQ+  A
Sbjct: 1051 CLRFECPPNYVQVSKTKCERTTCHDFLECQNSPA 1084



 Score =  138 bits (348), Expect = 3e-32
 Identities = 143/496 (28%), Positives = 198/496 (39%), Gaps = 67/496 (13%)

Query: 349  NSTHCQDINECAM-PG-VCRHGDCLNNPGSYRCVC--------------PPGHSLGPSRT 392
            NS    D +EC + PG +C+H  C+N  GSY C C              P GH   P   
Sbjct: 598  NSLPGDDQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP 656

Query: 393  QCIADKPEEKSLCFRLV----------SPEHQCQHPLTTRLTRQLCCCSVGKAW---GAR 439
            Q  A K E   +    +               C+   +T     +C C  G A    G  
Sbjct: 657  QEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 440  CQ---RCPTD-GTAAFKEICPAGKG----YHILTSHQTLTIQ-GE----SDFSLFLHPDG 486
            C+    C TD  T +  E C    G    Y  LT      ++ GE     + ++  H   
Sbjct: 717  CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQ 776

Query: 487  PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRP 546
            P    Q  +        +   +  G   D    E   V  +  T+ + P RP    I+  
Sbjct: 777  PGFLCQNTKGSFYCQARQRCMD--GFLQDP---EGNCVDINECTSLSEPCRPGFSCINTV 831

Query: 547  SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGY 605
               T +   P +           T+  + +EC    + CG G+ C   P  Y C C  G+
Sbjct: 832  GSYTCQRN-PLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 890

Query: 606  RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
            +     R C+DVNEC A P    +  C NT GSY C C  G+ L   A G+ C D+NEC 
Sbjct: 891  QRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL--AADGKRCEDVNECE 948

Query: 666  KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGS 724
                  +   C N  G Y+C C  GY+L A     C DIDEC   +      +C N PGS
Sbjct: 949  AQRCSQE---CANIYGSYQCYCRQGYQL-AEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1004

Query: 725  FKCIACQPGY-RSQGGGACRDVNECAEGS-PCSPG-WCENLPGSFRC---TCAQGYAPAP 778
            ++C   + GY  +  G +C+DV+ECA G+  CS    C N+ GSFRC    C   Y    
Sbjct: 1005 YQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVS 1064

Query: 779  ----DGRSCLDVDECE 790
                +  +C D  EC+
Sbjct: 1065 KTKCERTTCHDFLECQ 1080



 Score =  135 bits (340), Expect = 3e-31
 Identities = 204/859 (23%), Positives = 285/859 (33%), Gaps = 242/859 (28%)

Query: 484  PDGPPKPQ-------QLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPA 536
            P  P KP         LP++ +  PP  +   +  V   S V E+      H    ++P 
Sbjct: 377  PRDPVKPSPHNILSTSLPDA-AWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPE 435

Query: 537  RPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPD 596
                +LI        +W + +       +EI P   TE + CR  Q  C    CV    +
Sbjct: 436  GSTKDLIETCCAAGQQWAIDN----DECLEI-PESGTEDNVCRTAQRHC----CVSYLQE 486

Query: 597  YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
             SC                 +   E E CG              C    G  L V A G+
Sbjct: 487  KSCMAGV-------------LGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 657  SCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            SC      + P+L    G+  N   H   +C  G       P +  ++    +P++ P  
Sbjct: 534  SCE-----SNPNL----GYPCN---HVMLSCCEG-----EEPLIVPEVRRPPEPAAAPRR 576

Query: 717  KCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAP 776
              E                           E A     S G    LP S          P
Sbjct: 577  VSEA--------------------------EMAGREALSLGTEAELPNSL---------P 601

Query: 777  APDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC------------ 824
              D   CL +     G++C + +C NT GS+ C C  G+ L  D   C            
Sbjct: 602  GDDQDECLLLP----GELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP 656

Query: 825  -EDIDECDF--------------PAACIGGD-----CINTNGSYRCLCPQGHRLVG-GRK 863
             E   + +F              P  C         C    GS  C C  G+ ++  G  
Sbjct: 657  QEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 864  CQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDEGFTPTQDQHGCEEVEQPHHKKEC 919
            C+DI+EC  D   C     C N  GS+ C     C+ G+     +  CE+V+      EC
Sbjct: 717  CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVD------EC 768

Query: 920  YLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ 979
                         + T+  Q    C    G   +C+               C DG     
Sbjct: 769  ------------AMGTHTCQPGFLCQNTKG-SFYCQA-----------RQRCMDGFLQDP 804

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECY-----CKQGFYYDGNLLE 1033
            + N V        DI+EC    SE C+ G  C+NT   Y C      C +G++   +  +
Sbjct: 805  EGNCV--------DINECTSL-SEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK 855

Query: 1034 CVDVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPA 1090
            CVDV+EC      C  G VC N  G YRC C    +     R C+     DV+EC   P 
Sbjct: 856  CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-----DVNECWASPG 910

Query: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAG 1150
                  C N  GSYRC C   ++    G+ C           E  + C +QR     C+ 
Sbjct: 911  RLCQHTCENTLGSYRCSCASGFLLAADGKRC-----------EDVNECEAQR-----CSQ 954

Query: 1151 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1210
              A    ++  C CRQG         C                                 
Sbjct: 955  ECANIYGSYQ-CYCRQGYQLAEDGHTCT-------------------------------- 981

Query: 1211 EDSSEEDSDECRCVSG-----RCVPRPGGAVCECPG-GFQLDASRARCVDIDECRELNQR 1264
                  D DEC   +G     RC+  PG   C CP  G+ + A+   C D+DEC      
Sbjct: 982  ------DIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHN 1035

Query: 1265 GLLCKSERCVNTSGSFRCV 1283
                ++E C N  GSFRC+
Sbjct: 1036 --CSEAETCHNIQGSFRCL 1052



 Score =  119 bits (298), Expect = 2e-26
 Identities = 137/505 (27%), Positives = 185/505 (36%), Gaps = 143/505 (28%)

Query: 825  EDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDID-----ECSQDPSL- 876
            +D DEC   P       CINT GSY C C  G  L   GR C+        E  Q+P+L 
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 877  --------------------CLPHGACKNL----QGSYVCVCDEGFTPTQDQHGCEEVEQ 912
                                C  +G CK +     GS +C C  G+    D   CE++ +
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINE 722

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
                            C + L T    + C  +LG+        + C    + E      
Sbjct: 723  ----------------CVTDLHTCSRGEHCVNTLGS--------FHCYKALTCEPGYALK 758

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECY----CKQGFYY 1027
            DG+                 D+DEC + G+  C+ G  C NT+  + C     C  GF  
Sbjct: 759  DGEC---------------EDVDECAM-GTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQ 802

Query: 1028 D--GNLLECVDVDECLDESN-CRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDV 1083
            D  GN   CVD++EC   S  CR G  C NT G Y C   P              + +DV
Sbjct: 803  DPEGN---CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDV 859

Query: 1084 DECQDPA-ACRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDV--CW 1139
            +EC+     C  G+ C NLPGSYRC+C+  +     GR C              DV  CW
Sbjct: 860  NECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-------------DVNECW 906

Query: 1140 SQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDT 1199
            +  G   +C         ++  C C  G                                
Sbjct: 907  ASPGR--LCQHTCENTLGSYR-CSCASGF------------------------------- 932

Query: 1200 SPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1259
              LL     R ED +E ++  C   S  C    G   C C  G+QL      C DIDEC 
Sbjct: 933  --LLAADGKRCEDVNECEAQRC---SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECA 987

Query: 1260 ELNQRGLLCKSERCVNTSGSFRCVC 1284
            +    G+LC + RC+N  GS++C C
Sbjct: 988  Q--GAGILC-TFRCLNVPGSYQCAC 1009



 Score =  103 bits (257), Expect = 1e-21
 Identities = 123/458 (26%), Positives = 173/458 (37%), Gaps = 107/458 (23%)

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE---EVEQPHHKKECYLN 922
            D DEC   P     H  C N  GSY C C  GF+   D   C       QP   +E  L 
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 923  FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP-VYSSAEFHSLCPDGKGYTQDN 981
             + +    + +   + Q   C   G          PC  V S+    ++C    GY    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNG----------PCKQVCSTVGGSAICSCFPGYA--- 709

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYY-DGNLLECV 1035
             I+  G+    DI+EC+      C  G+ CVNT   + CY    C+ G+   DG   EC 
Sbjct: 710  -IMADGVSCE-DINECVT-DLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG---ECE 763

Query: 1036 DVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLS-----PEE--MDVDEC 1086
            DVDEC +    C+ G +C+NT+G + C          A+++C+      PE   +D++EC
Sbjct: 764  DVDECAMGTHTCQPGFLCQNTKGSFYCQ---------ARQRCMDGFLQDPEGNCVDINEC 814

Query: 1087 QDPAA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE 1144
               +  CRPG  C+N  GSY C+ R P +       C      ++   +  DV   + G 
Sbjct: 815  TSLSEPCRPGFSCINTVGSYTCQ-RNPLI-------CARGYHASDDGTKCVDVNECETGV 866

Query: 1145 DGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL 1204
                 G +         C C+ G    A  R C                           
Sbjct: 867  HRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-------------------------- 900

Query: 1205 GKPPRDEDSSEEDSDECRCVSGR-----CVPRPGGAVCECPGGFQLDASRARCVDIDECR 1259
                        D +EC    GR     C    G   C C  GF L A   RC D++EC 
Sbjct: 901  ------------DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECE 948

Query: 1260 ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
               QR   C S+ C N  GS++C C+ G+  +     C
Sbjct: 949  A--QR---C-SQECANIYGSYQCYCRQGYQLAEDGHTC 980



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 78/314 (24%), Positives = 109/314 (34%), Gaps = 56/314 (17%)

Query: 1030 NLLECVDVDECL--DESNCRNGVCENTRGGYRCACTP----------------PAEYSPA 1071
            N L   D DECL      C++ +C NT G Y CAC P                P +    
Sbjct: 598  NSLPGDDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP 656

Query: 1072 QRQCLSPEEMDV------------DECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR 1119
            Q   L  E   V            + C+D   C+   C  + GS  C C P +     G 
Sbjct: 657  QEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQV-CSTVGGSAICSCFPGYAIMADGV 715

Query: 1120 DCQ-LPESPAE-RAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC 1177
             C+ + E   +     R + C +  G           P     D  C            C
Sbjct: 716  SCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTC 775

Query: 1178 PPRGAGSHCPTSQSESNSFW-DTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP------ 1230
             P   G  C   Q+   SF+       +    +D + +  D +EC  +S  C P      
Sbjct: 776  QP---GFLC---QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 829

Query: 1231 RPGGAVCE-----CPGGFQLDASRARCVDIDECRELNQRGLLC-KSERCVNTSGSFRCVC 1284
              G   C+     C  G+       +CVD++EC     R   C + + C N  GS+RC C
Sbjct: 830  TVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHR---CGEGQVCHNLPGSYRCDC 886

Query: 1285 KAGFARSRPHGACV 1298
            KAGF R      C+
Sbjct: 887  KAGFQRDAFGRGCI 900



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 47/147 (31%), Positives = 59/147 (40%), Gaps = 24/147 (16%)

Query: 341 CPQGYKRLNS-THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIA 396
           C +GY   +  T C D+NEC   GV R G+   C N PGSYRC C  G         CI 
Sbjct: 843 CARGYHASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI- 900

Query: 397 DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARC--------QRCPT 445
               + + C+   SP   CQH     L    C C+ G    A G RC        QRC  
Sbjct: 901 ----DVNECW--ASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ 954

Query: 446 DGTAAFKEI-CPAGKGYHILTSHQTLT 471
           +    +    C   +GY +     T T
Sbjct: 955 ECANIYGSYQCYCRQGYQLAEDGHTCT 981



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 12/119 (10%)

Query: 282 DTLPKQPCGSNPL---PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
           +T+    C  NPL    G    +D    +     ++  H+C + Q      PG  R    
Sbjct: 829 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCH-NLPGSYR---- 883

Query: 339 ADCPQGYKR-LNSTHCQDINEC-AMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            DC  G++R      C D+NEC A PG +C+H  C N  GSYRC C  G  L     +C
Sbjct: 884 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRC 941



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCP-PG 384
            Q+   + G     C QGY+     H C DI+ECA   G+     CLN PGSY+C CP  G
Sbjct: 954  QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQG 1013

Query: 385  HSLGPSRTQC 394
            +++  +   C
Sbjct: 1014 YTMTANGRSC 1023



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 8/69 (11%)

Query: 333  VRGEVGADCP-QGYKRL-NSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCV---CPPGH 385
            V G     CP QGY    N   C+D++ECA+    C   + C N  GS+RC+   CPP +
Sbjct: 1001 VPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1060

Query: 386  SLGPSRTQC 394
             +  S+T+C
Sbjct: 1061 -VQVSKTKC 1068



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 42/157 (26%), Positives = 57/157 (36%), Gaps = 26/157 (16%)

Query: 234 HPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS-- 291
           HPP+          S     A +   LP P+P+     T K  G C      KQ C +  
Sbjct: 649 HPPQPEAPQEPALKSEFSQVASNTIPLPLPQPN-----TCKDNGPC------KQVCSTVG 697

Query: 292 -----NPLPGLTKQED--CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQG 344
                +  PG     D   C  I      +  H C + ++  V   G         C  G
Sbjct: 698 GSAICSCFPGYAIMADGVSCEDINEC--VTDLHTCSRGEHC-VNTLGSFHCYKALTCEPG 754

Query: 345 YKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRC 379
           Y  L    C+D++ECAM    C+ G  C N  GS+ C
Sbjct: 755 YA-LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC 790



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 1254 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300
            D DEC  L   G LC+   C+NT GS+ C C  GF+       C P+
Sbjct: 604  DQDECLLLP--GELCQ-HLCINTVGSYHCACFPGFSLQDDGRTCRPE 647


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  202 bits (513), Expect = 2e-51
 Identities = 142/379 (37%), Positives = 183/379 (48%), Gaps = 48/379 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562

Query: 901 TQDQHGCEEVEQPHHKKEC 919
           +     CE +   H  +EC
Sbjct: 563 SAATR-CERL-PCHENREC 579



 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  147 bits (372), Expect = 5e-35
 Identities = 116/394 (29%), Positives = 150/394 (38%), Gaps = 105/394 (26%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMDVDECQDPAA---------CRPG---------------------- 1095
              S   R C    E     C    A         CR G                      
Sbjct: 431  RLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 490

Query: 1096 ------RCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122
                  RC+N+PGS++C C    +   P+GR+CQ
Sbjct: 491  GHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524



 Score =  117 bits (293), Expect = 7e-26
 Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)

Query: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303

Query: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089
              C+D++ECL  S  C  G  C NT G Y C    P               +DVDEC  P
Sbjct: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
            A  C  G RCVN PGS+RCEC+  +      R C              DV   QR    +
Sbjct: 364  AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206
            C G      L    C C  G       R C      S  P SQ  +N +         G 
Sbjct: 411  C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469

Query: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258
               D D    ED DEC   +G      RC+  PG   C CP  G++L  +   C DIDEC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291
              +        +E C N  G FRC+   C   + RS
Sbjct: 530  --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)

Query: 852  CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
            C  GHR+   +K   +   ++     +    C + Q   +  C  G +   +Q  C    
Sbjct: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968
             PH                S+ AT V +   CC LG      G  CE      Y   +  
Sbjct: 94   -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140

Query: 969  SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              C          D  G  + + I+                G   CK+ +C +T     C
Sbjct: 141  RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073
             C  G+    + + C DV+EC+  S+ CR G  C NT G +RC    +C    E +    
Sbjct: 200  SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258

Query: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
             C      D+DEC+     C P   C N  GS+RC  RP                     
Sbjct: 259  SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290

Query: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
               +  C S   +D +      G  +  ++C             PCP    G  C  ++ 
Sbjct: 291  ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330

Query: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245
                  +      G    +E +   D DEC      C  G RCV  PG   CEC  G+  
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            D     CVD++EC+     G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 391  DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101
            N     +C+NT G +RC   P  +      Q      +D++EC   +A C  G  C+N  
Sbjct: 272  NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329

Query: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
            GSY C+   P      GR   L E                  E   C        +  D+
Sbjct: 330  GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359

Query: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
            C             P  P G G  C  S         T     G      D +E      
Sbjct: 360  CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
            R    +C    G  +C C  GF+L      C DI+EC         C S+ C N  GS++
Sbjct: 409  RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462

Query: 1282 CVCKAGFARSRPHG 1295
            C C+ G+  S   G
Sbjct: 463  CYCRRGYQLSDVDG 476



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 8/83 (9%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 386 SLGPSRTQCIADKPEEKSLCFRL 408
               + T+C      E   C +L
Sbjct: 561 RRS-AATRCERLPCHENRECSKL 582



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  202 bits (513), Expect = 2e-51
 Identities = 176/550 (32%), Positives = 226/550 (41%), Gaps = 96/550 (17%)

Query: 616  DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC----------------- 658
            D +EC   P    + +C+NT GSY+C C  G+ L     GR+C                 
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ--DDGRTCRPEGHPPQPEAPQEPAL 661

Query: 659  -VDLNECA---------KPHLCGDGG----FCINFPGHYKCNCYPGYRLKASRPPVCEDI 704
              + ++ A         +P+ C D G     C    G   C+C+PGY + A     CED 
Sbjct: 662  KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS-CEDQ 720

Query: 705  DEC-RDPSSCPDGK-CENKPGSFKCI----ACQPGYRSQGGGACRDVNECAEG-SPCSPG 757
            DEC      C   + C N  GSF C+     C  GY       C D+NEC      CS G
Sbjct: 721  DECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRG 780

Query: 758  -WCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNTPGSFQCQ 810
              C N  GSF C    TC  GYA   DG  C DVDEC  G   C  G +C NT GSF CQ
Sbjct: 781  EHCVNTLGSFHCYKALTCEPGYA-LKDGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYCQ 838

Query: 811  ----CLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRC-----LCPQG-HRL 858
                C+ G+ L     +C DI+EC      C  G  CINT GSY C     +C +G H  
Sbjct: 839  ARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHAS 897

Query: 859  VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
              G KC D++EC      C     C NL GSY C C  GF       GC +V       E
Sbjct: 898  DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDV------NE 951

Query: 919  CYLNFDDTVFCDSVLATNVTQQECCCSLG---AGWGDHCE-IYPCPVYSSAE-------- 966
            C+ +      C       +    C C+ G   A  G  CE +  C     ++        
Sbjct: 952  CWAS--PGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGS 1009

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC-KQGF 1025
            +   C  G    +D +          DIDEC   G+ I    +C+N    Y+C C +QG+
Sbjct: 1010 YQCYCRQGYQLAEDGHTCT-------DIDECAQ-GAGILCTFRCLNVPGSYQCACPEQGY 1061

Query: 1026 YYDGNLLECVDVDEC-LDESNCRNG-VCENTRGGYRCAC--TPPAEYSPAQRQCLSPEEM 1081
                N   C DVDEC L   NC     C N +G +RC     PP     ++ +C      
Sbjct: 1062 TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCH 1121

Query: 1082 DVDECQDPAA 1091
            D  ECQ+  A
Sbjct: 1122 DFLECQNSPA 1131



 Score =  201 bits (512), Expect = 3e-51
 Identities = 134/351 (38%), Positives = 175/351 (49%), Gaps = 36/351 (10%)

Query: 568  APTQVTETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECE- 621
            A  +  + +EC  + + C  GE CV     + C+    C PGY        C DV+EC  
Sbjct: 760  AHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAM 817

Query: 622  -AEPCGPGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGF 675
                C PG  +C NT GS+ C     C  G+ L    G  +CVD+NEC      C  G  
Sbjct: 818  GTHTCQPGF-LCQNTKGSFYCQARQRCMDGF-LQDPEG--NCVDINECTSLSEPCRPGFS 873

Query: 676  CINFPGHYKCN-----CYPGYRLKASRPPVCEDIDECRDP-SSCPDGK-CENKPGSFKCI 728
            CIN  G Y C      C  GY         C D++EC      C +G+ C N PGS++C 
Sbjct: 874  CINTVGSYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRCGEGQVCHNLPGSYRC- 931

Query: 729  ACQPGY-RSQGGGACRDVNEC--AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
             C+ G+ R   G  C DVNEC  + G  C    CEN  GS+RC+CA G+  A DG+ C D
Sbjct: 932  DCKAGFQRDAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRCED 990

Query: 786  VDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINT 844
            V+ECEA        C+N  GS+QC C  GY L+ D   C DIDEC   A  +    C+N 
Sbjct: 991  VNECEAQRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNV 1048

Query: 845  NGSYRCLCP-QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             GSY+C CP QG+ +   GR C+D+DEC+     C     C N+QGS+ C+
Sbjct: 1049 PGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1099



 Score =  139 bits (350), Expect = 2e-32
 Identities = 201/842 (23%), Positives = 289/842 (34%), Gaps = 203/842 (24%)

Query: 484  PDGPPKPQ-------QLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPA 536
            P  P KP         LP++ +  PP  +   +  V   S V E+      H    ++P 
Sbjct: 377  PRDPVKPSPHNILSTSLPDA-AWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPE 435

Query: 537  RPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPD 596
                +LI        +W + +       +EI P   TE + CR  Q  C    CV    +
Sbjct: 436  GSTKDLIETCCAAGQQWAIDN----DECLEI-PESGTEDNVCRTAQRHC----CVSYLQE 486

Query: 597  YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
             SC                 +   E E CG              C    G  L V A G+
Sbjct: 487  KSCMAGV-------------LGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 657  SCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            SC      + P+L    G+  N   H   +C  G       P +  ++    +P++ P  
Sbjct: 534  SCE-----SNPNL----GYPCN---HVMLSCCEG-----EEPLIVPEVRRPPEPAAAPRR 576

Query: 717  KCENKPGSFKCIACQPGYRSQGGGACRDVNECA--EGSPCSPGWCENLPGSFRCTCAQGY 774
              E +    + ++              D +EC    G  C    C N  GS+ C C  G+
Sbjct: 577  VSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQH-LCINTVGSYHCACFPGF 635

Query: 775  APAPDGRSCLDVD-------------ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDR 821
            +   DGR+C                 + E   V  N I    P    C         +D 
Sbjct: 636  SLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTC---------KDN 686

Query: 822  SHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPH 880
              C+ +             C    GS  C C  G+ ++  G  C+D DEC      C   
Sbjct: 687  GPCKQV-------------CSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRR 733

Query: 881  GACKNLQGSYVCV-----CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935
              C N  GS+ CV     C +G+     +  C ++ +                C + L T
Sbjct: 734  QFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINE----------------CVTDLHT 776

Query: 936  NVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
                + C  +LG+        + C    + E      DG+                 D+D
Sbjct: 777  CSRGEHCVNTLGS--------FHCYKALTCEPGYALKDGEC---------------EDVD 813

Query: 996  ECMLFGSEICKEG-KCVNTQPGYECY----CKQGFYYD--GNLLECVDVDECLDESN-CR 1047
            EC + G+  C+ G  C NT+  + C     C  GF  D  GN   CVD++EC   S  CR
Sbjct: 814  ECAM-GTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN---CVDINECTSLSEPCR 869

Query: 1048 NGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA-ACRPGR-CVNLPGSY 1104
             G  C NT G Y C   P              + +DV+EC+     C  G+ C NLPGSY
Sbjct: 870  PGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSY 929

Query: 1105 RCECRPPWVPGPSGRDCQLPESPAERAPERRDV--CWSQRGEDGMCAGPLAGPALTFDDC 1162
            RC+C+  +     GR C              DV  CW+  G   +C         ++  C
Sbjct: 930  RCDCKAGFQRDAFGRGCI-------------DVNECWASPGR--LCQHTCENTLGSYR-C 973

Query: 1163 CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR 1222
             C  G                                  LL     R ED +E ++  C 
Sbjct: 974  SCASGF---------------------------------LLAADGKRCEDVNECEAQRC- 999

Query: 1223 CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1282
              S  C    G   C C  G+QL      C DIDEC +    G+LC + RC+N  GS++C
Sbjct: 1000 --SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQ--GAGILC-TFRCLNVPGSYQC 1054

Query: 1283 VC 1284
             C
Sbjct: 1055 AC 1056



 Score =  137 bits (344), Expect = 9e-32
 Identities = 85/233 (36%), Positives = 114/233 (48%), Gaps = 18/233 (7%)

Query: 570  TQVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
            T+  + +EC    + CG G+ C   P  Y C C  G++     R C+DVNEC A P    
Sbjct: 901  TKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC 960

Query: 629  RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY 688
            +  C NT GSY C C  G+ L   A G+ C D+NEC       +   C N  G Y+C C 
Sbjct: 961  QHTCENTLGSYRCSCASGFLL--AADGKRCEDVNECEAQRCSQE---CANIYGSYQCYCR 1015

Query: 689  PGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGY-RSQGGGACRDVN 746
             GY+L A     C DIDEC   +      +C N PGS++C   + GY  +  G +C+DV+
Sbjct: 1016 QGYQL-AEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1074

Query: 747  ECAEGS-PCSPG-WCENLPGSFRC---TCAQGYAPAP----DGRSCLDVDECE 790
            ECA G+  CS    C N+ GSFRC    C   Y        +  +C D  EC+
Sbjct: 1075 ECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1127



 Score =  119 bits (297), Expect = 2e-26
 Identities = 125/445 (28%), Positives = 171/445 (38%), Gaps = 91/445 (20%)

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE---EVEQPHHKKECYLN 922
            D DEC   P     H  C N  GSY C C  GF+   D   C       QP   +E  L 
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 923  FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP-VYSSAEFHSLCPDGKGYTQDN 981
             + +    + +   + Q   C   G          PC  V S+    ++C    GY    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNG----------PCKQVCSTVGGSAICSCFPGYA--- 709

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL----ECVDV 1037
             I+  G+    D DEC++   +  +   CVNT   + C        DG +L    +CVD+
Sbjct: 710  -IMADGVSCE-DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDI 767

Query: 1038 DECL-DESNCRNGV-CENTRGGYRC--ACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAAC 1092
            +EC+ D   C  G  C NT G + C  A T    Y+    +C      DVDEC      C
Sbjct: 768  NECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGEC-----EDVDECAMGTHTC 822

Query: 1093 RPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGP 1151
            +PG  C N  GS+ C+ R                               QR  DG    P
Sbjct: 823  QPGFLCQNTKGSFYCQAR-------------------------------QRCMDGFLQDP 851

Query: 1152 LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL--GKPPR 1209
              G  +  ++C         +   PC P   G  C  +          +PL+   G    
Sbjct: 852  -EGNCVDINECT--------SLSEPCRP---GFSCINTVGSYTC--QRNPLICARGYHAS 897

Query: 1210 DEDSSEEDSDEC-----RCVSGR-CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1263
            D+ +   D +EC     RC  G+ C   PG   C+C  GFQ DA    C+D++EC     
Sbjct: 898  DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC--WAS 955

Query: 1264 RGLLCKSERCVNTSGSFRCVCKAGF 1288
             G LC+   C NT GS+RC C +GF
Sbjct: 956  PGRLCQ-HTCENTLGSYRCSCASGF 979



 Score =  109 bits (273), Expect = 1e-23
 Identities = 141/530 (26%), Positives = 195/530 (36%), Gaps = 162/530 (30%)

Query: 825  EDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDID-----ECSQDPSL- 876
            +D DEC   P       CINT GSY C C  G  L   GR C+        E  Q+P+L 
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 877  --------------------CLPHGACKNL----QGSYVCVCDEGFTPTQDQHGCEEVEQ 912
                                C  +G CK +     GS +C C  G+    D   CE+ + 
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQD- 721

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
                 EC +   D   C         +Q C  +LG+             +       LC 
Sbjct: 722  -----ECLMGAHD---CSR-------RQFCVNTLGS-------------FYCVNHTVLCA 753

Query: 973  DGKGYTQDNNIVNYGIPAHR---DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQG 1024
            DG           Y + AHR   DI+EC+      C  G+ CVNT   + CY    C+ G
Sbjct: 754  DG-----------YILNAHRKCVDINECVT-DLHTCSRGEHCVNTLGSFHCYKALTCEPG 801

Query: 1025 FYY-DGNLLECVDVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLS---- 1077
            +   DG   EC DVDEC +    C+ G +C+NT+G + C          A+++C+     
Sbjct: 802  YALKDG---ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQ---------ARQRCMDGFLQ 849

Query: 1078 -PEE--MDVDECQDPAA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAP 1132
             PE   +D++EC   +  CRPG  C+N  GSY C+ R P +       C      ++   
Sbjct: 850  DPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQ-RNPLI-------CARGYHASDDGT 901

Query: 1133 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE 1192
            +  DV   + G      G +         C C+ G    A  R C               
Sbjct: 902  KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-------------- 947

Query: 1193 SNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR-----CVPRPGGAVCECPGGFQLDA 1247
                                    D +EC    GR     C    G   C C  GF L A
Sbjct: 948  ------------------------DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAA 983

Query: 1248 SRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
               RC D++EC    QR   C S+ C N  GS++C C+ G+  +     C
Sbjct: 984  DGKRCEDVNECEA--QR---C-SQECANIYGSYQCYCRQGYQLAEDGHTC 1027



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 84/360 (23%), Positives = 117/360 (32%), Gaps = 70/360 (19%)

Query: 993  DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC------------------ 1034
            D DEC+L   E+C+   C+NT   Y C C  GF    +   C                  
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 1035 ---------------VDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
                              + C D   C+  VC    G   C+C P          C    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIMADGVSC---- 717

Query: 1080 EMDVDECQDPA--ACRPGRCVNLPGSYRCE-----CRPPWVPGPSGRDCQLPESPAE-RA 1131
              D DEC   A    R   CVN  GS+ C      C   ++     +   + E   +   
Sbjct: 718  -EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHT 776

Query: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
              R + C +  G           P     D  C            C P   G  C   Q+
Sbjct: 777  CSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQP---GFLC---QN 830

Query: 1192 ESNSFW-DTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP------RPGGAVCE-----C 1239
               SF+       +    +D + +  D +EC  +S  C P        G   C+     C
Sbjct: 831  TKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLIC 890

Query: 1240 PGGFQLDASRARCVDIDECRELNQRGLLC-KSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
              G+       +CVD++EC     R   C + + C N  GS+RC CKAGF R      C+
Sbjct: 891  ARGYHASDDGTKCVDVNECETGVHR---CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 947



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 47/147 (31%), Positives = 59/147 (40%), Gaps = 24/147 (16%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIA 396
            C +GY   +  T C D+NEC   GV R G+   C N PGSYRC C  G         CI 
Sbjct: 890  CARGYHASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI- 947

Query: 397  DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARC--------QRCPT 445
                + + C+   SP   CQH     L    C C+ G    A G RC        QRC  
Sbjct: 948  ----DVNECW--ASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ 1001

Query: 446  DGTAAFKEI-CPAGKGYHILTSHQTLT 471
            +    +    C   +GY +     T T
Sbjct: 1002 ECANIYGSYQCYCRQGYQLAEDGHTCT 1028



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 12/119 (10%)

Query: 282 DTLPKQPCGSNPL---PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
           +T+    C  NPL    G    +D    +     ++  H+C + Q      PG  R    
Sbjct: 876 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCH-NLPGSYR---- 930

Query: 339 ADCPQGYKR-LNSTHCQDINEC-AMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            DC  G++R      C D+NEC A PG +C+H  C N  GSYRC C  G  L     +C
Sbjct: 931 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRC 988



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCP-PG 384
            Q+   + G     C QGY+     H C DI+ECA   G+     CLN PGSY+C CP  G
Sbjct: 1001 QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQG 1060

Query: 385  HSLGPSRTQC 394
            +++  +   C
Sbjct: 1061 YTMTANGRSC 1070



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 8/69 (11%)

Query: 333  VRGEVGADCP-QGYKRL-NSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCV---CPPGH 385
            V G     CP QGY    N   C+D++ECA+    C   + C N  GS+RC+   CPP +
Sbjct: 1048 VPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1107

Query: 386  SLGPSRTQC 394
             +  S+T+C
Sbjct: 1108 -VQVSKTKC 1115



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 3/48 (6%)

Query: 349 NSTHCQDINECAM-PG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           NS    D +EC + PG +C+H  C+N  GSY C C PG SL      C
Sbjct: 598 NSLPGDDQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTC 644



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 6/53 (11%)

Query: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGD-CLNNPGSYRC----VCPPGHSL 387
           C  GY       C DINEC      C  G+ C+N  GS+ C     C PG++L
Sbjct: 752 CADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYAL 804



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 1254 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300
            D DEC  L   G LC+   C+NT GS+ C C  GF+       C P+
Sbjct: 604  DQDECLLLP--GELCQ-HLCINTVGSYHCACFPGFSLQDDGRTCRPE 647



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 3/41 (7%)

Query: 341 CPQGYKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRC 379
           C  GY  L    C+D++ECAM    C+ G  C N  GS+ C
Sbjct: 798 CEPGYA-LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC 837


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  201 bits (511), Expect = 4e-51
 Identities = 148/446 (33%), Positives = 193/446 (43%), Gaps = 71/446 (15%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY---C 1021
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C    C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRCLAFEC 556

Query: 1022 KQGFYYDGNLLECVDVDECLDESNCR 1047
             + +      L+    D      +CR
Sbjct: 557  PENYRRSAATLQQEKTDTVRCIKSCR 582



 Score =  201 bits (510), Expect = 5e-51
 Identities = 143/388 (36%), Positives = 184/388 (47%), Gaps = 46/388 (11%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562

Query: 901 TQDQHGCEEVEQPHHKKECYLNFDDTVF 928
           +      E+ +     K C  N    VF
Sbjct: 563 SAATLQQEKTDTVRCIKSCRPNDVTCVF 590



 Score =  186 bits (473), Expect = 1e-46
 Identities = 142/435 (32%), Positives = 196/435 (45%), Gaps = 75/435 (17%)

Query: 685  CNCYPGYRLKASRPPVCEDIDECRDPS-SCPDGK-CENKPGSFKC---IACQPGYRSQGG 739
            C+C+ GY+L  S    CED++EC   S SC  G+ C N  GSF+C    +C  GY     
Sbjct: 199  CSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED 257

Query: 740  GACRDVNECAEG-SPCSPGW-CENLPGSFRCT----CAQGYAPAPDGRSCLDVDEC-EAG 792
             +C+D++EC  G   C P + C+N  GSFRC     C  G+     G +C+D++EC    
Sbjct: 258  NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSIS 316

Query: 793  DVCDNG-ICSNTPGSFQCQ-----CLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINT 844
              C  G  C NT GS+ CQ     C  GYHL+ + + C D+DEC  PA   G    C+N+
Sbjct: 317  APCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNS 376

Query: 845  NGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQD 903
             GS+RC C  G+   G  R C D++EC + P     H  C+N  GSY+C C  GF  + D
Sbjct: 377  PGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVD 435

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
               CE++       EC              +++   QEC    G+        Y C    
Sbjct: 436  GRSCEDIN------EC--------------SSSPCSQECANVYGS--------YQC---- 463

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML-FGSEICKEGKCVNTQPGYECYC- 1021
                   C  G   +  + +         DIDEC L  G  IC   +C+N    ++C C 
Sbjct: 464  ------YCRRGYQLSDVDGVTC------EDIDECALPTGGHICSY-RCINIPGSFQCSCP 510

Query: 1022 KQGFYYDGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
              G+    N   C D+DEC+    NC  N  C N +GG+RC      E        L  E
Sbjct: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQE 570

Query: 1080 EMDVDECQDPAACRP 1094
            + D   C    +CRP
Sbjct: 571  KTDTVRC--IKSCRP 583



 Score =  147 bits (372), Expect = 5e-35
 Identities = 116/394 (29%), Positives = 150/394 (38%), Gaps = 105/394 (26%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMDVDECQDPAA---------CRPG---------------------- 1095
              S   R C    E     C    A         CR G                      
Sbjct: 431  RLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 490

Query: 1096 ------RCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122
                  RC+N+PGS++C C    +   P+GR+CQ
Sbjct: 491  GHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524



 Score =  117 bits (293), Expect = 7e-26
 Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)

Query: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303

Query: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089
              C+D++ECL  S  C  G  C NT G Y C    P               +DVDEC  P
Sbjct: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
            A  C  G RCVN PGS+RCEC+  +      R C              DV   QR    +
Sbjct: 364  AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206
            C G      L    C C  G       R C      S  P SQ  +N +         G 
Sbjct: 411  C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469

Query: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258
               D D    ED DEC   +G      RC+  PG   C CP  G++L  +   C DIDEC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291
              +        +E C N  G FRC+   C   + RS
Sbjct: 530  --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)

Query: 852  CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
            C  GHR+   +K   +   ++     +    C + Q   +  C  G +   +Q  C    
Sbjct: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968
             PH                S+ AT V +   CC LG      G  CE      Y   +  
Sbjct: 94   -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140

Query: 969  SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              C          D  G  + + I+                G   CK+ +C +T     C
Sbjct: 141  RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073
             C  G+    + + C DV+EC+  S+ CR G  C NT G +RC    +C    E +    
Sbjct: 200  SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258

Query: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
             C      D+DEC+     C P   C N  GS+RC  RP                     
Sbjct: 259  SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290

Query: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
               +  C S   +D +      G  +  ++C             PCP    G  C  ++ 
Sbjct: 291  ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330

Query: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245
                  +      G    +E +   D DEC      C  G RCV  PG   CEC  G+  
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            D     CVD++EC+     G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 391  DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101
            N     +C+NT G +RC   P  +      Q      +D++EC   +A C  G  C+N  
Sbjct: 272  NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329

Query: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
            GSY C+   P      GR   L E                  E   C        +  D+
Sbjct: 330  GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359

Query: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
            C             P  P G G  C  S         T     G      D +E      
Sbjct: 360  CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
            R    +C    G  +C C  GF+L      C DI+EC         C S+ C N  GS++
Sbjct: 409  RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462

Query: 1282 CVCKAGFARSRPHG 1295
            C C+ G+  S   G
Sbjct: 463  CYCRRGYQLSDVDG 476



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  200 bits (508), Expect = 8e-51
 Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+  E
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555



 Score =  147 bits (372), Expect = 5e-35
 Identities = 116/394 (29%), Positives = 150/394 (38%), Gaps = 105/394 (26%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMDVDECQDPAA---------CRPG---------------------- 1095
              S   R C    E     C    A         CR G                      
Sbjct: 431  RLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 490

Query: 1096 ------RCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122
                  RC+N+PGS++C C    +   P+GR+CQ
Sbjct: 491  GHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524



 Score =  117 bits (293), Expect = 7e-26
 Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)

Query: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303

Query: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089
              C+D++ECL  S  C  G  C NT G Y C    P               +DVDEC  P
Sbjct: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
            A  C  G RCVN PGS+RCEC+  +      R C              DV   QR    +
Sbjct: 364  AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206
            C G      L    C C  G       R C      S  P SQ  +N +         G 
Sbjct: 411  C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469

Query: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258
               D D    ED DEC   +G      RC+  PG   C CP  G++L  +   C DIDEC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291
              +        +E C N  G FRC+   C   + RS
Sbjct: 530  --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)

Query: 852  CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
            C  GHR+   +K   +   ++     +    C + Q   +  C  G +   +Q  C    
Sbjct: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968
             PH                S+ AT V +   CC LG      G  CE      Y   +  
Sbjct: 94   -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140

Query: 969  SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              C          D  G  + + I+                G   CK+ +C +T     C
Sbjct: 141  RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073
             C  G+    + + C DV+EC+  S+ CR G  C NT G +RC    +C    E +    
Sbjct: 200  SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258

Query: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
             C      D+DEC+     C P   C N  GS+RC  RP                     
Sbjct: 259  SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290

Query: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
               +  C S   +D +      G  +  ++C             PCP    G  C  ++ 
Sbjct: 291  ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330

Query: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245
                  +      G    +E +   D DEC      C  G RCV  PG   CEC  G+  
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            D     CVD++EC+     G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 391  DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101
            N     +C+NT G +RC   P  +      Q      +D++EC   +A C  G  C+N  
Sbjct: 272  NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329

Query: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
            GSY C+   P      GR   L E                  E   C        +  D+
Sbjct: 330  GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359

Query: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
            C             P  P G G  C  S         T     G      D +E      
Sbjct: 360  CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
            R    +C    G  +C C  GF+L      C DI+EC         C S+ C N  GS++
Sbjct: 409  RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462

Query: 1282 CVCKAGFARSRPHG 1295
            C C+ G+  S   G
Sbjct: 463  CYCRRGYQLSDVDG 476



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  200 bits (508), Expect = 8e-51
 Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+  E
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555



 Score =  147 bits (372), Expect = 5e-35
 Identities = 116/394 (29%), Positives = 150/394 (38%), Gaps = 105/394 (26%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMDVDECQDPAA---------CRPG---------------------- 1095
              S   R C    E     C    A         CR G                      
Sbjct: 431  RLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 490

Query: 1096 ------RCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122
                  RC+N+PGS++C C    +   P+GR+CQ
Sbjct: 491  GHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524



 Score =  117 bits (293), Expect = 7e-26
 Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)

Query: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303

Query: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089
              C+D++ECL  S  C  G  C NT G Y C    P               +DVDEC  P
Sbjct: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
            A  C  G RCVN PGS+RCEC+  +      R C              DV   QR    +
Sbjct: 364  AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410

Query: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206
            C G      L    C C  G       R C      S  P SQ  +N +         G 
Sbjct: 411  C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469

Query: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258
               D D    ED DEC   +G      RC+  PG   C CP  G++L  +   C DIDEC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291
              +        +E C N  G FRC+   C   + RS
Sbjct: 530  --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)

Query: 852  CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
            C  GHR+   +K   +   ++     +    C + Q   +  C  G +   +Q  C    
Sbjct: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968
             PH                S+ AT V +   CC LG      G  CE      Y   +  
Sbjct: 94   -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140

Query: 969  SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              C          D  G  + + I+                G   CK+ +C +T     C
Sbjct: 141  RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073
             C  G+    + + C DV+EC+  S+ CR G  C NT G +RC    +C    E +    
Sbjct: 200  SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258

Query: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
             C      D+DEC+     C P   C N  GS+RC  RP                     
Sbjct: 259  SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290

Query: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
               +  C S   +D +      G  +  ++C             PCP    G  C  ++ 
Sbjct: 291  ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330

Query: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245
                  +      G    +E +   D DEC      C  G RCV  PG   CEC  G+  
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
            D     CVD++EC+     G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 391  DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101
            N     +C+NT G +RC   P  +      Q      +D++EC   +A C  G  C+N  
Sbjct: 272  NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329

Query: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
            GSY C+   P      GR   L E                  E   C        +  D+
Sbjct: 330  GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359

Query: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
            C             P  P G G  C  S         T     G      D +E      
Sbjct: 360  CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
            R    +C    G  +C C  GF+L      C DI+EC         C S+ C N  GS++
Sbjct: 409  RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462

Query: 1282 CVCKAGFARSRPHG 1295
            C C+ G+  S   G
Sbjct: 463  CYCRRGYQLSDVDG 476



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|190343004 EGF-containing fibulin-like extracellular matrix
           protein 2 [Homo sapiens]
          Length = 443

 Score =  190 bits (482), Expect = 9e-48
 Identities = 115/302 (38%), Positives = 144/302 (47%), Gaps = 27/302 (8%)

Query: 595 PDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNCHCNRGYRLHVGA 653
           PD    C  GY   P  ++C DVNEC   P    G   C+N  G Y C            
Sbjct: 33  PDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------- 81

Query: 654 GGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDP-SS 712
             RS   +N+     L G+G      P  +   C PGY  +      C D+DEC      
Sbjct: 82  -PRSAAVIND-----LHGEGPPPPVPPAQHPNPCPPGY--EPDDQDSCVDVDECAQALHD 133

Query: 713 C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA 771
           C P   C N PGS++C  C  GYR  G   C D++EC     C    C NLPGSFRC C 
Sbjct: 134 CRPSQDCHNLPGSYQC-TCPDGYRKIGP-ECVDIDECRYRY-CQHR-CVNLPGSFRCQCE 189

Query: 772 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD 831
            G+   P+ RSC+DV+EC+ G  C+   C N+ G+F C+C  GY L RD   C DIDEC 
Sbjct: 190 PGFQLGPNNRSCVDVNECDMGAPCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECS 248

Query: 832 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
           + +      C+N  G + C CPQG++L+  R CQDIDEC      C     C N  G Y 
Sbjct: 249 YSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308

Query: 892 CV 893
           CV
Sbjct: 309 CV 310



 Score =  132 bits (331), Expect = 3e-30
 Identities = 87/271 (32%), Positives = 123/271 (45%), Gaps = 46/271 (16%)

Query: 482 LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
           LH +GPP P    + P+  PP  + +++     DS V  +   Q  H    +      P 
Sbjct: 91  LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-----DSCVDVDECAQALHDCRPSQDCHNLPG 145

Query: 542 LISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHC 601
                 P   R             +I P +  + DECR     C H  CV  P  + C C
Sbjct: 146 SYQCTCPDGYR-------------KIGP-ECVDIDECRYRY--CQH-RCVNLPGSFRCQC 188

Query: 602 NPGYRSHPQHRYCVDVNECE-AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            PG++  P +R CVDVNEC+   PC      C N+ G++ C C++GY LH    G SC D
Sbjct: 189 EPGFQLGPNNRSCVDVNECDMGAPC---EQRCFNSYGTFLCRCHQGYELH--RDGFSCSD 243

Query: 661 LNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
           ++EC+   +LC     C+N PG + C+C  GY+L A+R  +C+DIDEC            
Sbjct: 244 IDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQLLATR--LCQDIDEC------------ 287

Query: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAE 750
            + G+ +C   Q      GG  C D N C E
Sbjct: 288 -ESGAHQCSEAQTCVNFHGGYRCVDTNRCVE 317



 Score =  109 bits (272), Expect = 2e-23
 Identities = 97/361 (26%), Positives = 131/361 (36%), Gaps = 93/361 (25%)

Query: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRCL------- 851
            S  P S+  +C  GY    D  HC D++EC   P AC G   CIN  G Y CL       
Sbjct: 30   SEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVI 88

Query: 852  --------------------CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
                                CP G+       C D+DEC+Q    C P   C NL GSY 
Sbjct: 89   NDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148

Query: 892  CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG 951
            C C +G+     +  C ++++  ++           +C          Q  C +L   + 
Sbjct: 149  CTCPDGYRKIGPE--CVDIDECRYR-----------YC----------QHRCVNLPGSFR 185

Query: 952  DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV 1011
              CE    P +     +  C        D N  + G P                 E +C 
Sbjct: 186  CQCE----PGFQLGPNNRSC-------VDVNECDMGAPC----------------EQRCF 218

Query: 1012 NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA 1071
            N+   + C C QG+    +   C D+DEC   S      C N  G + C C P      A
Sbjct: 219  NSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHC-PQGYQLLA 277

Query: 1072 QRQCLSPEEMDVDECQDPA-ACRPGR-CVNLPGSYRC----ECRPPWVPGPSGRDCQLPE 1125
             R C      D+DEC+  A  C   + CVN  G YRC     C  P++     R C  P 
Sbjct: 278  TRLC-----QDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR-CLCPA 331

Query: 1126 S 1126
            S
Sbjct: 332  S 332



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 101/351 (28%), Positives = 130/351 (37%), Gaps = 117/351 (33%)

Query: 971  CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK-EGKCVNTQPGYECY--------- 1020
            C DG  +  D+          RD++EC+    E CK E KC+N   GY C          
Sbjct: 39   CTDGYEWDPDSQHC-------RDVNECLTI-PEACKGEMKCINHYGGYLCLPRSAAVIND 90

Query: 1021 ------------------CKQGFYYDGNLLECVDVDECLDE-SNCRNGV-CENTRGGYRC 1060
                              C  G+  D     CVDVDEC     +CR    C N  G Y+C
Sbjct: 91   LHGEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQC 149

Query: 1061 ACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRD 1120
             C       P   + + PE +D+DEC+    C+  RCVNLPGS+RC+C P          
Sbjct: 150  TC-------PDGYRKIGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEP---------- 190

Query: 1121 CQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPR 1180
                                     G   GP     +  ++C        GA   PC  R
Sbjct: 191  -------------------------GFQLGPNNRSCVDVNEC------DMGA---PCEQR 216

Query: 1181 GAGSH----CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG----RCVPRP 1232
               S+    C   Q              G     +  S  D DEC   S     RCV  P
Sbjct: 217  CFNSYGTFLCRCHQ--------------GYELHRDGFSCSDIDECSYSSYLCQYRCVNEP 262

Query: 1233 GGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1283
            G   C CP G+QL A+R  C DIDEC     +    +++ CVN  G +RCV
Sbjct: 263  GRFSCHCPQGYQLLATRL-CQDIDECESGAHQ--CSEAQTCVNFHGGYRCV 310



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 79/308 (25%), Positives = 102/308 (33%), Gaps = 99/308 (32%)

Query: 1014 QPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV--CENTRGGYRCACT-------- 1063
            +P     C  G+ +D +   C DV+ECL       G   C N  GGY C           
Sbjct: 32   EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91

Query: 1064 ----PPAEYSPAQRQCLSPEE---------MDVDEC-QDPAACRPGR-CVNLPGSYRCEC 1108
                PP    PAQ     P           +DVDEC Q    CRP + C NLPGSY+C C
Sbjct: 92   HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151

Query: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC------ 1162
                           P+   +  PE  D+                      D+C      
Sbjct: 152  ---------------PDGYRKIGPECVDI----------------------DECRYRYCQ 174

Query: 1163 --CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
              C      +  QC P    G  +      +E +         +G P             
Sbjct: 175  HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD---------MGAPCEQ---------- 215

Query: 1221 CRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280
                  RC    G  +C C  G++L      C DIDEC   +    LC+  RCVN  G F
Sbjct: 216  ------RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLCQ-YRCVNEPGRF 265

Query: 1281 RCVCKAGF 1288
             C C  G+
Sbjct: 266  SCHCPQGY 273



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 67/248 (27%), Positives = 94/248 (37%), Gaps = 57/248 (22%)

Query: 1062 CTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPG-RCVNLPGSYRCECRPPWVPGPSGR 1119
            CT   E+ P  + C      DV+EC   P AC+   +C+N  G Y C  R   V      
Sbjct: 39   CTDGYEWDPDSQHC-----RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93

Query: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC-----CRQGRGWGAQC 1174
            +   P  P  + P      +    +D           +  D+C      CR  +     C
Sbjct: 94   EGPPPPVPPAQHPNPCPPGYEPDDQDS---------CVDVDECAQALHDCRPSQ----DC 140

Query: 1175 RPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC--VSGRCV 1229
               P    GS+   CP      + +    P  +            D DECR      RCV
Sbjct: 141  HNLP----GSYQCTCP------DGYRKIGPECV------------DIDECRYRYCQHRCV 178

Query: 1230 PRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFA 1289
              PG   C+C  GFQL  +   CVD++EC      G  C+ +RC N+ G+F C C  G+ 
Sbjct: 179  NLPGSFRCQCEPGFQLGPNNRSCVDVNEC----DMGAPCE-QRCFNSYGTFLCRCHQGYE 233

Query: 1290 RSRPHGAC 1297
              R   +C
Sbjct: 234  LHRDGFSC 241



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 39/135 (28%), Positives = 52/135 (38%), Gaps = 32/135 (23%)

Query: 265 PSHPRPPTQKPLGRCFQDTLPKQPCGSNPLP----GLTKQEDCCGSIGTAWGQSKCHKCP 320
           P  P PP Q P            PC     P         ++C  ++        CH  P
Sbjct: 96  PPPPVPPAQHP-----------NPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLP 144

Query: 321 QLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCV 380
                         G     CP GY+++    C DI+EC     C+H  C+N PGS+RC 
Sbjct: 145 --------------GSYQCTCPDGYRKIGP-ECVDIDECRYR-YCQHR-CVNLPGSFRCQ 187

Query: 381 CPPGHSLGPSRTQCI 395
           C PG  LGP+   C+
Sbjct: 188 CEPGFQLGPNNRSCV 202



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 56/206 (27%), Positives = 76/206 (36%), Gaps = 24/206 (11%)

Query: 255 PSQHLLPHPKPSHPRPPTQKP---LGRCFQ---DTLPKQPCGSNPLPGLTKQEDCCGSIG 308
           P+QH  P+P P    P  Q     +  C Q   D  P Q C + P        D    IG
Sbjct: 102 PAQH--PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIG 159

Query: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKR-LNSTHCQDINECAMPGVCRH 367
                    +    Q+  V  PG  R      C  G++   N+  C D+NEC M   C  
Sbjct: 160 PECVDIDECRYRYCQHRCVNLPGSFR----CQCEPGFQLGPNNRSCVDVNECDMGAPCEQ 215

Query: 368 GDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLC-FRLVSP--EHQCQHP---- 418
             C N+ G++ C C  G+ L      C  I +      LC +R V+      C  P    
Sbjct: 216 -RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274

Query: 419 -LTTRLTRQLCCCSVGKAWGARCQRC 443
            L TRL + +  C  G    +  Q C
Sbjct: 275 LLATRLCQDIDECESGAHQCSEAQTC 300



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 30/84 (35%), Positives = 37/84 (44%), Gaps = 11/84 (13%)

Query: 323 QYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV 380
           QY  V +PG         CPQGY+ L +  CQDI+EC      C     C+N  G YRCV
Sbjct: 255 QYRCVNEPG----RFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310

Query: 381 -----CPPGHSLGPSRTQCIADKP 399
                  P   +  +R  C A  P
Sbjct: 311 DTNRCVEPYIQVSENRCLCPASNP 334



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 22/115 (19%)

Query: 1186 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1245
            C +    S   W    LLLG     +DS E DS                   EC  G++ 
Sbjct: 4    CASCLPGSLLLWALLLLLLGSAS-PQDSEEPDS-----------------YTECTDGYEW 45

Query: 1246 DASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKAGFARSRPHGACVP 1299
            D     C D++EC  + +    CK E +C+N  G + C+ ++    +  HG   P
Sbjct: 46   DPDSQHCRDVNECLTIPE---ACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 3/44 (6%)

Query: 340 DCPQGYK-RLNSTHCQDINEC-AMPGVCR-HGDCLNNPGSYRCV 380
           +C  GY+   +S HC+D+NEC  +P  C+    C+N+ G Y C+
Sbjct: 38  ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL 81


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  187 bits (476), Expect = 4e-47
 Identities = 116/369 (31%), Positives = 164/369 (44%), Gaps = 56/369 (15%)

Query: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
           + DEC    + C     C   P  Y C C  GY    +H  C DV+ECE E        C
Sbjct: 29  DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVHDC 86

Query: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGF---CINFPGHYKCNCYP 689
           +N  G+Y C C  G+  H+   G +C+D++ECA+    G+GG    C+N  G Y+C+C  
Sbjct: 87  VNIPGNYRCTCYDGF--HLAHDGHNCLDVDECAE----GNGGCQQSCVNMMGSYECHCRE 140

Query: 690 GYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR----------- 735
           G+ L  ++    +  +E   C + +      C   P       C+PG+            
Sbjct: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 200

Query: 736 -SQGGGACR----------------------DVNECAEGSPCSPGWCEN----LPGSFRC 768
            + G G C+                      D   C E    + G C++          C
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHC 260

Query: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828
           TC  G+   PD ++C D+DEC   +   + IC NT GSF+C C  GY L  +  +C+DID
Sbjct: 261 TCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDID 320

Query: 829 ECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQG 888
           EC F   C    C+NT GS++CLC +G+ L G   C D+DECS +   C     C N  G
Sbjct: 321 ECSFDRTC-DHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPG 377

Query: 889 SYVCVCDEG 897
           SY C C  G
Sbjct: 378 SYQCTCPAG 386



 Score =  161 bits (408), Expect = 3e-39
 Identities = 154/539 (28%), Positives = 222/539 (41%), Gaps = 101/539 (18%)

Query: 781  RSCLDVDECEAG-DVCD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFP--AAC 836
            ++  DVDEC  G D C  + IC NTP S++C C SGY  + D  HC+D+DEC+    A C
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82

Query: 837  IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCD 895
            +  DC+N  G+YRC C  G  L   G  C D+DEC++    C    +C N+ GSY C C 
Sbjct: 83   VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC--QQSCVNMMGSYECHCR 139

Query: 896  EGFTPTQDQHGCEEVEQPHHKKECYLNFDDT-----------VFCDSVLATNVTQQECCC 944
            EGF  + +QH C  +++P     C                  + C+      +T+ +  C
Sbjct: 140  EGFFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197

Query: 945  SLGAGWG--------DHCEIYP-CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAH---- 991
             L   +G        D  E  P C  +     H+   DGK   +   + N G  +     
Sbjct: 198  KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHT---DGKTCIETCAVNNGGCDSKCHDA 254

Query: 992  ---------------------RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN 1030
                                 +DIDEC L       +  C NT   +EC CK+G+    N
Sbjct: 255  ATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLIN 312

Query: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ-DP 1089
               C D+DEC  +  C + +C NT G ++C C            C      DVDEC  + 
Sbjct: 313  ERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHR-GYLLYGITHC-----GDVDECSINR 365

Query: 1090 AACRPGRCVNLPGSYRCEC-----RPPWVPGPSGRDCQLP-ESPAERAPERRDVCWSQRG 1143
              CR G C+N PGSY+C C     R  W    +G+DC  P +        +  +  ++ G
Sbjct: 366  GGCRFG-CINTPGSYQCTCPAGQGRLHW----NGKDCTEPLKCQGSPGASKAMLSCNRSG 420

Query: 1144 EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1203
            +   CA      A    +       G+   C    PR A +    + + +NS       +
Sbjct: 421  KKDTCALTCPSRARFLPE----SENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAV 476

Query: 1204 LGKPPRDEDSSEEDSDECRC---------VSGRCVPRPGGAVC-ECPGGF---QLDASR 1249
            L    R   S +    +CR           +GR +  PGGA C EC   F   + D+SR
Sbjct: 477  LSIKQR--ASFKIKDAKCRLHLRNKGKTEEAGR-ITGPGGAPCSECQVTFIHLKCDSSR 532



 Score =  140 bits (354), Expect = 6e-33
 Identities = 122/464 (26%), Positives = 185/464 (39%), Gaps = 110/464 (23%)

Query: 656  RSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR--DPSS 712
            ++  D++EC +    C     C N P  YKC C  GY         C+D+DEC   D + 
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH---CKDVDECEREDNAG 81

Query: 713  CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQ 772
            C    C N PG+++C      + +  G  C DV+ECAEG+      C N+ GS+ C C +
Sbjct: 82   CVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCRE 140

Query: 773  GYAPAPDGRSCLDVDECEAGDVCDNG------ICSNTP-GSFQCQCLSGYHLSRDRSHCE 825
            G+  + +  +C  +   E G  C N       IC  TP G   C+C  G+ L++++  C+
Sbjct: 141  GFFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK 198

Query: 826  ------------DIDECDFPAAC----------IGGDCINT----NGS-----------Y 848
                          D+ +    C           G  CI T    NG             
Sbjct: 199  LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGV 258

Query: 849  RCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGC 907
             C CP G  L   RK C+DIDEC  +   C     C+N  GS+ C C +G+    ++  C
Sbjct: 259  HCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERNC 316

Query: 908  EEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967
            ++++      EC  +FD T  CD +        +C C                       
Sbjct: 317  QDID------EC--SFDRT--CDHICVNTPGSFQCLCH---------------------- 344

Query: 968  HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQG--- 1024
                   +GY      + YGI    D+DEC +     C+ G C+NT   Y+C C  G   
Sbjct: 345  -------RGY------LLYGITHCGDVDECSI-NRGGCRFG-CINTPGSYQCTCPAGQGR 389

Query: 1025 FYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR--CACTPPA 1066
             +++G   +C +  +C         +    R G +  CA T P+
Sbjct: 390  LHWNGK--DCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431



 Score =  100 bits (248), Expect = 1e-20
 Identities = 94/351 (26%), Positives = 130/351 (37%), Gaps = 55/351 (15%)

Query: 952  DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV 1011
            D+C I      +   +  +C  G  YT D           +D+DEC    +  C    CV
Sbjct: 38   DNCHIDAICQNTPRSYKCICKSG--YTGDGKHC-------KDVDECEREDNAGCVHD-CV 87

Query: 1012 NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA 1071
            N    Y C C  GF+   +   C+DVDEC + +      C N  G Y C C      S  
Sbjct: 88   NIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDN 147

Query: 1072 QRQCLSPEEMDVDECQDPAACRPGRCVNLP-GSYRCECRPPWVPGPSGRDCQLPESPAER 1130
            Q  C+   E  ++ C +        C   P G   CECRP +    + RDC+L  +    
Sbjct: 148  QHTCIQRPEEGMN-CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNG 206

Query: 1131 APERRDVCWSQRGEDGMCAGPLAGPALTF---------DDCCCRQGRGWGAQCRPCPPRG 1181
                      Q   D    GP  G  + F          + C     G  ++C       
Sbjct: 207  G--------CQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDA---A 255

Query: 1182 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR----CVPRPGGAVC 1237
             G HC            T P  +G   + +  + +D DECR  +G     C    G   C
Sbjct: 256  TGVHC------------TCP--VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFEC 301

Query: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288
             C  G++L  +   C DIDEC         C    CVNT GSF+C+C  G+
Sbjct: 302  SCKKGYKLLINERNCQDIDEC----SFDRTC-DHICVNTPGSFQCLCHRGY 347



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 36/94 (38%), Positives = 45/94 (47%), Gaps = 6/94 (6%)

Query: 1205 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
            GK  +D D  E + D   CV   CV  PG   C C  GF L      C+D+DEC E N  
Sbjct: 65   GKHCKDVDECERE-DNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG 122

Query: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
               C+ + CVN  GS+ C C+ GF  S     C+
Sbjct: 123  ---CQ-QSCVNMMGSYECHCREGFFLSDNQHTCI 152



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 23/45 (51%), Positives = 30/45 (66%), Gaps = 2/45 (4%)

Query: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPG 384
           C +GY     THC D++EC++  G CR G C+N PGSY+C CP G
Sbjct: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 2/54 (3%)

Query: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C +GYK L N  +CQDI+EC+    C H  C+N PGS++C+C  G+ L
Sbjct: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 5/86 (5%)

Query: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
           + G     C  G+   +  H C D++ECA         C+N  GSY C C  G  L  ++
Sbjct: 89  IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148

Query: 392 TQCIADKPEEKSLCFRLVSPEHQCQH 417
             CI  +PEE   C   ++  H C H
Sbjct: 149 HTCI-QRPEEGMNC---MNKNHGCAH 170



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 341 CPQGYKRLNSTHCQDINECAMP--GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
           C  GY   +  HC+D++EC       C H DC+N PG+YRC C  G  L      C+
Sbjct: 57  CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL 111



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 10/119 (8%)

Query: 698 PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPG 757
           PP    +D  +    CP G  + + G   C  C  G  ++  GA     +C     CSPG
Sbjct: 694 PPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAI-SFQDCDTKVQCSPG 752

Query: 758 WCENLP---------GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
              N           GS++    Q +     G +  D D   +   C N  C    G F
Sbjct: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811



 Score = 37.7 bits (86), Expect = 0.072
 Identities = 32/101 (31%), Positives = 42/101 (41%), Gaps = 19/101 (18%)

Query: 296 GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQ 354
           G T  E C  + G     SKCH       TGV             CP G+  + +   C+
Sbjct: 233 GKTCIETCAVNNGGC--DSKCHDAA----TGVH----------CTCPVGFMLQPDRKTCK 276

Query: 355 DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           DI+EC +  G C H  C N  GS+ C C  G+ L  +   C
Sbjct: 277 DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 2/39 (5%)

Query: 350 STHCQDINECAMPGVCRHGD--CLNNPGSYRCVCPPGHS 386
           S   QD++EC       H D  C N P SY+C+C  G++
Sbjct: 24  SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT 62



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

Query: 1254 DIDECRELNQRGLLCKSER-CVNTSGSFRCVCKAGFARSRPH 1294
            D+DEC E       C  +  C NT  S++C+CK+G+     H
Sbjct: 29   DVDECVEGTDN---CHIDAICQNTPRSYKCICKSGYTGDGKH 67


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  185 bits (470), Expect = 2e-46
 Identities = 180/687 (26%), Positives = 253/687 (36%), Gaps = 152/687 (22%)

Query: 585  CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGRGICMNTG-GSYNCH 642
            C HG CV     + C+C   +      +   D+N C +  PC  G G C+N     Y C 
Sbjct: 282  CVHGSCVE---PWQCNCETNWGGLLCDK---DLNYCGSHHPCTNG-GTCINAEPDQYRCT 334

Query: 643  CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE 702
            C  GY       GR+C         + C +GG C   P  ++C+C  G+    S P    
Sbjct: 335  CPDGY------SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCAL 384

Query: 703  DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVNECAEGSPCSPGWCEN 761
            DIDEC        G C ++   F+CI  +       G  C+ DVN+C  G     G C++
Sbjct: 385  DIDECASNPCAAGGTCVDQVDGFECICPEQWV----GATCQLDVNDC-RGQCQHGGTCKD 439

Query: 762  LPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 820
            L   ++C C +G+     GR C L+ DEC +      G+C +    F C C  G+     
Sbjct: 440  LVNGYQCVCPRGFG----GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF----S 491

Query: 821  RSHCE-DIDECDFPAAC-IGGDCINTNGSYRCLCPQG---------HRLVGGRKCQDIDE 869
               CE D+D C+ P+ C  G  C N  G Y C CP                G  C+ ID 
Sbjct: 492  GPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG 550

Query: 870  CSQD----------PSLCLPHGACKNLQ-GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
            C  D            +C PHG C +   G++ C+CD GFT T                 
Sbjct: 551  CGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTY---------------- 594

Query: 919  CYLNFDDTVF--C--DSVLATNVTQQECCCSLGAGW-GDHC-----EIYPCPVYSSA--- 965
            C+ N DD +   C         V    C C   +GW G+ C     +  P P +S     
Sbjct: 595  CHENIDDCLGQPCRNGGTCIDEVDAFRCFCP--SGWEGELCDTNPNDCLPDPCHSRGRCY 652

Query: 966  ----EFHSLCPDG-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020
                +F+  C DG KG T            H    +C  +       G C ++   + C 
Sbjct: 653  DLVNDFYCACDDGWKGKT-----------CHSREFQCDAY--TCSNGGTCYDSGDTFRCA 699

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
            C  G  + G+         CL       G C  +   + C C    E     R C     
Sbjct: 700  CPPG--WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTH--- 750

Query: 1081 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS 1140
             + ++C        G CV+    +RCEC     PG +G DC++     + +P        
Sbjct: 751  -NTNDCNPLPCYNGGICVDGVNWFRCEC----APGFAGPDCRINIDECQSSP-------- 797

Query: 1141 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200
                   CA         +   C  +  G+  +C  CPP  AG  C        S W   
Sbjct: 798  -------CA---------YGATCVDEINGY--RC-SCPPGRAGPRCQEVIGFGRSCWSR- 837

Query: 1201 PLLLGKPPRDEDSSEEDSDECRCVSGR 1227
                G P     S  ED + CRC+ GR
Sbjct: 838  ----GTPFPHGSSWVEDCNSCRCLDGR 860



 Score =  174 bits (440), Expect = 6e-43
 Identities = 187/721 (25%), Positives = 265/721 (36%), Gaps = 148/721 (20%)

Query: 578  CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
            C+   N+   G  VPG     C C+ G+    Q R+C   +EC   P G   G C+    
Sbjct: 245  CKQGCNLLHGGCTVPG----ECRCSYGW----QGRFC---DECVPYP-GCVHGSCVEP-- 290

Query: 638  SYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINF-PGHYKCNCYPGYRLKA 695
             + C+C   +      GG  C  DLN C   H C +GG CIN  P  Y+C C  GY  + 
Sbjct: 291  -WQCNCETNW------GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343

Query: 696  SRPPVCEDIDECRDPSSCPDG-KCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPC 754
                 CE  +     + C +G  C   P  F+C  C  G+   G     D++ECA     
Sbjct: 344  -----CEKAEHACTSNPCANGGSCHEVPSGFEC-HCPSGW--SGPTCALDIDECASNPCA 395

Query: 755  SPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
            + G C +    F C C + +     G +C LDV++C  G     G C +    +QC C  
Sbjct: 396  AGGTCVDQVDGFECICPEQWV----GATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPR 450

Query: 814  GYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECS 871
            G+       HCE + DEC       GG C +    + C CPQG     G  C+ D+D C 
Sbjct: 451  GF----GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF---SGPLCEVDVDLC- 502

Query: 872  QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDS 931
             +PS C     C NL+G Y C C + F        C    +P     C +   D    D+
Sbjct: 503  -EPSPCRNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGACRVI--DGCGSDA 555

Query: 932  VLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAH 991
                  T     C      G H     C       F  +C  G  +T        G   H
Sbjct: 556  GPGMPGTAASGVC------GPHGR---CVSQPGGNFSCICDSG--FT--------GTYCH 596

Query: 992  RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVC 1051
             +ID+C+  G      G C++    + C+C  G  ++G L +  + ++CL +     G C
Sbjct: 597  ENIDDCL--GQPCRNGGTCIDEVDAFRCFCPSG--WEGELCD-TNPNDCLPDPCHSRGRC 651

Query: 1052 ENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPP 1111
             +    + CAC    +     + C S E     +C        G C +   ++RC C P 
Sbjct: 652  YDLVNDFYCACDDGWK----GKTCHSREF----QCDAYTCSNGGTCYDSGDTFRCACPPG 703

Query: 1112 WVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWG 1171
            W     G  C + ++ +         C      +G   G   G   +F  C CR G  W 
Sbjct: 704  W----KGSTCAVAKNSS---------CLPNPCVNG---GTCVGSGASFS-CICRDG--W- 743

Query: 1172 AQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPR 1231
                       G  C  + ++ N      P   G                    G CV  
Sbjct: 744  ----------EGRTCTHNTNDCNPL----PCYNG--------------------GICVDG 769

Query: 1232 PGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARS 1291
                 CEC  GF     R   ++IDEC    Q         CV+    +RC C  G A  
Sbjct: 770  VNWFRCECAPGFAGPDCR---INIDEC----QSSPCAYGATCVDEINGYRCSCPPGRAGP 822

Query: 1292 R 1292
            R
Sbjct: 823  R 823



 Score =  125 bits (315), Expect = 2e-28
 Identities = 155/606 (25%), Positives = 229/606 (37%), Gaps = 151/606 (24%)

Query: 729  ACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788
            AC  G+    G  C++   C +G     G C  +PG   C C+ G+     GR C   DE
Sbjct: 230  ACMDGWM---GKECKEA-VCKQGCNLLHGGC-TVPGE--CRCSYGW----QGRFC---DE 275

Query: 789  CEAGDVCDNGICSNTPGSFQCQCLS---GYHLSRDRSHCEDIDECDFPAACIGGDCINTN 845
            C     C +G C      +QC C +   G    +D ++C     C       GG CIN  
Sbjct: 276  CVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTN-----GGTCINAE 327

Query: 846  -GSYRCLCPQGHRLVGGRKCQDIDE-CSQDPSLCLPHGACKNLQGSYVCVCDEGFT-PTQ 902
               YRC CP G+    GR C+  +  C+ +P  C   G+C  +   + C C  G++ PT 
Sbjct: 328  PDQYRCTCPDGY---SGRNCEKAEHACTSNP--CANGGSCHEVPSGFECHCPSGWSGPT- 381

Query: 903  DQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVY 962
                            C L+ D+        A+N       C+ G    D  + + C   
Sbjct: 382  ----------------CALDIDEC-------ASNP------CAAGGTCVDQVDGFEC--- 409

Query: 963  SSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCK 1022
                   +CP+             G     D+++C     +    G C +   GY+C C 
Sbjct: 410  -------ICPEQW----------VGATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCP 449

Query: 1023 QGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMD 1082
            +GF   G   E ++ DEC        G+CE+   G+ C C P     P    C    E+D
Sbjct: 450  RGF--GGRHCE-LERDECASSPCHSGGLCEDLADGFHCHC-PQGFSGPL---C----EVD 498

Query: 1083 VDECQDPAACRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERR-DVCWS 1140
            VD C+ P+ CR G RC NL G Y C C   +     G++C +P  P      R  D C S
Sbjct: 499  VDLCE-PSPCRNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGACRVIDGCGS 553

Query: 1141 QRGED--GMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1198
              G    G  A  + GP      C  + G  +   C        G++C  +  +      
Sbjct: 554  DAGPGMPGTAASGVCGP---HGRCVSQPGGNFSCIC---DSGFTGTYCHENIDDC----- 602

Query: 1199 TSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCEC-PGGFQLDA--SRARCVDI 1255
                 LG+P R+  +  ++ D  RC    C     G +C+  P     D   SR RC D+
Sbjct: 603  -----LGQPCRNGGTCIDEVDAFRCF---CPSGWEGELCDTNPNDCLPDPCHSRGRCYDL 654

Query: 1256 DE-----CRELNQRGLLCKSER-------------CVNTSGSFRCVCKAGFARS----RP 1293
                   C +   +G  C S               C ++  +FRC C  G+  S      
Sbjct: 655  VNDFYCACDD-GWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAK 713

Query: 1294 HGACVP 1299
            + +C+P
Sbjct: 714  NSSCLP 719



 Score =  111 bits (278), Expect = 4e-24
 Identities = 166/673 (24%), Positives = 229/673 (34%), Gaps = 167/673 (24%)

Query: 678  NFPGHYKCN------CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQ 731
            +F GHY C+      C  G+  K  +  VC      +   +   G C   PG  +C    
Sbjct: 216  DFFGHYTCDQYGNKACMDGWMGKECKEAVC------KQGCNLLHGGC-TVPGECRC---- 264

Query: 732  PGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECE 790
              Y  QG    R  +EC     C  G C      ++C C   +     G  C  D++ C 
Sbjct: 265  -SYGWQG----RFCDECVPYPGCVHGSCVE---PWQCNCETNWG----GLLCDKDLNYCG 312

Query: 791  AGDVCDNG-ICSNT-PGSFQCQCLSGYHLSRDRSHCEDIDE-CDFPAACIGGDCINTNGS 847
            +   C NG  C N  P  ++C C  GY       +CE  +  C       GG C      
Sbjct: 313  SHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSG 368

Query: 848  YRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDE---GFTPTQD 903
            + C CP G     G  C  DIDEC+ +P  C   G C +    + C+C E   G T   D
Sbjct: 369  FECHCPSGW---SGPTCALDIDECASNP--CAAGGTCVDQVDGFECICPEQWVGATCQLD 423

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
             + C    Q  H   C                 V   +C C  G G G HCE+       
Sbjct: 424  VNDCRG--QCQHGGTC--------------KDLVNGYQCVCPRGFG-GRHCEL------- 459

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
                                         + DEC    S     G C +   G+ C+C Q
Sbjct: 460  -----------------------------ERDECA--SSPCHSGGLCEDLADGFHCHCPQ 488

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEE-- 1080
            GF   G L E VDVD C + S CRNG  C N  G Y CAC  P ++    + C  P E  
Sbjct: 489  GF--SGPLCE-VDVDLC-EPSPCRNGARCYNLEGDYYCAC--PDDFGG--KNCSVPREPC 540

Query: 1081 -----MDVDECQDPAA-----------CRP-GRCVNLPG-SYRCECRPPW--------VP 1114
                   +D C   A            C P GRCV+ PG ++ C C   +        + 
Sbjct: 541  PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 600

Query: 1115 GPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGW---- 1170
               G+ C+   +  +     R  C+   G +G        P     D C  +GR +    
Sbjct: 601  DCLGQPCRNGGTCIDEVDAFR--CFCPSGWEGELCD--TNPNDCLPDPCHSRGRCYDLVN 656

Query: 1171 --------GAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR 1222
                    G + + C  R       T  +    +          PP  + S+   +    
Sbjct: 657  DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 716

Query: 1223 CV------SGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNT 1276
            C+       G CV       C C  G++    R    + ++C  L           CV+ 
Sbjct: 717  CLPNPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLP----CYNGGICVDG 769

Query: 1277 SGSFRCVCKAGFA 1289
               FRC C  GFA
Sbjct: 770  VNWFRCECAPGFA 782



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 11/61 (18%)

Query: 114 PLPCMNGGQCSSRN---QCLCPPDFTGRFCQVPAGGAGGGT--------GGSGPGLSRTG 162
           P PC NG +C +      C CP DF G+ C VP     GG           +GPG+  T 
Sbjct: 504 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTA 563

Query: 163 A 163
           A
Sbjct: 564 A 564



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 43/179 (24%), Positives = 68/179 (37%), Gaps = 35/179 (19%)

Query: 289 CGSNPLPGL--TKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK 346
           CGS+  PG+  T     CG  G         +C       V +PG   G     C  G+ 
Sbjct: 551 CGSDAGPGMPGTAASGVCGPHG---------RC-------VSQPG---GNFSCICDSGF- 590

Query: 347 RLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCP---PGHSLGPSRTQCIADKPEEK 402
               T+C +  +  +   CR+G  C++   ++RC CP    G     +   C+ D    +
Sbjct: 591 --TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSR 648

Query: 403 SLCFRLVSPEH-QCQHPL--TTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
             C+ LV+  +  C       T  +R+  C +   + G  C     D    F+  CP G
Sbjct: 649 GRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY----DSGDTFRCACPPG 703



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 39/138 (28%), Positives = 54/138 (39%), Gaps = 25/138 (18%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCP---PGHSLGPSRTQCIA 396
           CP+ +  + +T   D+N+C   G C+HG  C +    Y+CVCP    G      R +C +
Sbjct: 411 CPEQW--VGATCQLDVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466

Query: 397 DKPEEKSLCFRLVSPEH-QCQHPLTTRLTR---QLCCCSVGKAWGARCQR--------CP 444
                  LC  L    H  C    +  L      LC  S  +  GARC          CP
Sbjct: 467 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRN-GARCYNLEGDYYCACP 525

Query: 445 TD----GTAAFKEICPAG 458
            D      +  +E CP G
Sbjct: 526 DDFGGKNCSVPREPCPGG 543



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 36/118 (30%), Positives = 50/118 (42%), Gaps = 20/118 (16%)

Query: 276 LGRCFQDTLPKQPCGSNPLPG-LTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
           +G+  ++ + KQ C  N L G  T   +C  S G  W    C +C       V  PG V 
Sbjct: 236 MGKECKEAVCKQGC--NLLHGGCTVPGECRCSYG--WQGRFCDEC-------VPYPGCVH 284

Query: 335 GEV----GADCPQGYKRLNSTHCQDINECAMPGVCRHGD-CLN-NPGSYRCVCPPGHS 386
           G        +C   +  L     +D+N C     C +G  C+N  P  YRC CP G+S
Sbjct: 285 GSCVEPWQCNCETNWGGLLCD--KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS 340



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 27/91 (29%), Positives = 32/91 (35%), Gaps = 15/91 (16%)

Query: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRG--------EVGADCPQGYKRLNSTHCQDINECA 360
           T WG   C K   L Y G   P    G        +    CP GY   N   C+      
Sbjct: 297 TNWGGLLCDK--DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN---CEKAEHAC 351

Query: 361 MPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 390
               C +G  C   P  + C CP G S GP+
Sbjct: 352 TSNPCANGGSCHEVPSGFECHCPSGWS-GPT 381



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 25/84 (29%), Positives = 34/84 (40%), Gaps = 17/84 (20%)

Query: 299 KQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINE 358
           K E  C S   A G S CH+ P    +G +            CP G+     T   DI+E
Sbjct: 346 KAEHACTSNPCANGGS-CHEVP----SGFE----------CHCPSGWS--GPTCALDIDE 388

Query: 359 CAMPGVCRHGDCLNNPGSYRCVCP 382
           CA       G C++    + C+CP
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICP 412



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 14/56 (25%)

Query: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGP 389
           G  G DC     R+N   CQ          C +G  C++    YRC CPPG + GP
Sbjct: 780 GFAGPDC-----RINIDECQS-------SPCAYGATCVDEINGYRCSCPPGRA-GP 822



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 14/74 (18%)

Query: 80  CRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQCSSRNQ--- 128
           CR  CQ G     +  NG+      G G R   C L        PC +GG C        
Sbjct: 427 CRGQCQHGGTCKDL-VNGYQCVCPRGFGGRH--CELERDECASSPCHSGGLCEDLADGFH 483

Query: 129 CLCPPDFTGRFCQV 142
           C CP  F+G  C+V
Sbjct: 484 CHCPQGFSGPLCEV 497



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 12/30 (40%), Positives = 17/30 (56%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCSSRN----QCLCPPDFTGRFCQ 141
           PC NGG C +      +C CP  ++GR C+
Sbjct: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCE 345



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 114 PLPCMNGGQC---SSRNQCLCPPDFTGRFCQV 142
           PLPC NGG C    +  +C C P F G  C++
Sbjct: 757 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRI 788



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 18/54 (33%), Positives = 21/54 (38%), Gaps = 11/54 (20%)

Query: 117 CMNGGQCSSRN---QCLCPPDFTGRFCQVPAGGA--------GGGTGGSGPGLS 159
           C NGG C       +C CPP + G  C V    +        GG   GSG   S
Sbjct: 683 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 18/122 (14%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
           C  G++    TH  + N+C        G C++    +RC C PG + GP    C  +  E
Sbjct: 739 CRDGWEGRTCTH--NTNDCNPLPCYNGGICVDGVNWFRCECAPGFA-GP---DCRINIDE 792

Query: 401 EKSLCFRLVSPEHQCQHPLT--TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
            +S      SP   C +  T    +    C C  G+A G RCQ     G + +    P  
Sbjct: 793 CQS------SP---CAYGATCVDEINGYRCSCPPGRA-GPRCQEVIGFGRSCWSRGTPFP 842

Query: 459 KG 460
            G
Sbjct: 843 HG 844


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  184 bits (466), Expect = 6e-46
 Identities = 186/697 (26%), Positives = 259/697 (37%), Gaps = 134/697 (19%)

Query: 585  CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGRGICMNTG-GSYNCH 642
            C HG CV     + C+C   +      +   D+N C +  PC  G G C+N     Y C 
Sbjct: 282  CVHGSCVE---PWQCNCETNWGGLLCDK---DLNYCGSHHPCTNG-GTCINAEPDQYRCT 334

Query: 643  CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE 702
            C  GY       GR+C         + C +GG C   P  ++C+C  G+    S P    
Sbjct: 335  CPDGY------SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCAL 384

Query: 703  DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVNECAEGSPCSPGW-CE 760
            DIDEC        G C ++   F+CI  +       G  C+ D NEC EG PC   + C+
Sbjct: 385  DIDECASNPCAAGGTCVDQVDGFECICPEQWV----GATCQLDANEC-EGKPCLNAFSCK 439

Query: 761  NLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819
            NL G + C C  G+     G +C ++V++C  G     G C +    +QC C  G+    
Sbjct: 440  NLIGGYYCDCIPGWK----GINCHINVNDCR-GQCQHGGTCKDLVNGYQCVCPRGF---- 490

Query: 820  DRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLC 877
               HCE + DEC       GG C +    + C CPQG     G  C+ D+D C  +PS C
Sbjct: 491  GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF---SGPLCEVDVDLC--EPSPC 545

Query: 878  LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
                 C NL+G Y C C + F        C    +P     C +   D    D+      
Sbjct: 546  RNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGACRVI--DGCGSDAGPGMPG 599

Query: 938  TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
            T     C      G H     C       F  +C  G  +T        G   H +ID+C
Sbjct: 600  TAASGVC------GPHGR---CVSQPGGNFSCICDSG--FT--------GTYCHENIDDC 640

Query: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGG 1057
            +  G      G C++    + C+C  G  ++G L +  + ++CL +     G C +    
Sbjct: 641  L--GQPCRNGGTCIDEVDAFRCFCPSG--WEGELCD-TNPNDCLPDPCHSRGRCYDLVND 695

Query: 1058 YRCACTP--------PAEYSPAQRQCLSP----EEMDVDECQDP-------------AAC 1092
            + CAC            E+      C +     +  D   C  P             ++C
Sbjct: 696  FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC 755

Query: 1093 RP------GRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAP-ERRDVCWSQRGED 1145
             P      G CV    S+ C CR  W     GR C    +     P     +C      D
Sbjct: 756  LPNPCVNGGTCVGSGASFSCICRDGW----EGRTCTHNTNDCNPLPCYNGGIC-----VD 806

Query: 1146 GM------CAGPLAGPALTFD-DCCCRQGRGWGAQCRP--------CPPRGAGSHCPTSQ 1190
            G+      CA   AGP    + D C      +GA C          CPP  AG  C    
Sbjct: 807  GVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866

Query: 1191 SESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR 1227
                S W       G P     S  ED + CRC+ GR
Sbjct: 867  GFGRSCWSR-----GTPFPHGSSWVEDCNSCRCLDGR 898



 Score =  155 bits (391), Expect = 3e-37
 Identities = 182/722 (25%), Positives = 259/722 (35%), Gaps = 187/722 (25%)

Query: 578  CRLNQNICGH-------GECVPGPPD-YSCHCNPGYRSHPQHRYCVDVNE-CEAEPCGPG 628
            C  + N CG        G C+   PD Y C C  GY      R C      C + PC  G
Sbjct: 304  CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG----RNCEKAEHACTSNPCANG 359

Query: 629  RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY 688
             G C      + CHC  G+     +G    +D++ECA  + C  GG C++    ++C C 
Sbjct: 360  -GSCHEVPSGFECHCPSGW-----SGPTCALDIDECAS-NPCAAGGTCVDQVDGFECIC- 411

Query: 689  PGYRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVN 746
            P   + A+    C+ D +EC          C+N  G + C  C PG++   G  C  +VN
Sbjct: 412  PEQWVGAT----CQLDANECEGKPCLNAFSCKNLIGGYYC-DCIPGWK---GINCHINVN 463

Query: 747  ECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICSNTPG 805
            +C  G     G C++L   ++C C +G+     GR C L+ DEC +      G+C +   
Sbjct: 464  DC-RGQCQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASSPCHSGGLCEDLAD 518

Query: 806  SFQCQCLSGYHLSRDRSHCE-DIDECDFPAACIGGD-CINTNGSYRCLCPQG-------- 855
             F C C  G+        CE D+D C+ P+ C  G  C N  G Y C CP          
Sbjct: 519  GFHCHCPQGF----SGPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573

Query: 856  -HRLVGGRKCQDIDECSQDPS----------LCLPHGACKNLQG-SYVCVCDEGFTPTQD 903
                  G  C+ ID C  D            +C PHG C +  G ++ C+CD GFT T  
Sbjct: 574  PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTY- 632

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVF--CDS--VLATNVTQQECCCSLGAGW-GDHCEIYP 958
                           C+ N DD +   C +       V    C C   +GW G+ C+  P
Sbjct: 633  ---------------CHENIDDCLGQPCRNGGTCIDEVDAFRCFCP--SGWEGELCDTNP 675

Query: 959  --C---PVYSSA-------EFHSLCPDG-KG------------YTQDNNIVNY------- 986
              C   P +S         +F+  C DG KG            YT  N    Y       
Sbjct: 676  NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 735

Query: 987  -GIPAHRDIDECMLFGSEIC------KEGKCVNTQPGYECYCKQGFY------------- 1026
               P       C +  +  C        G CV +   + C C+ G+              
Sbjct: 736  CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 795

Query: 1027 ---YDGNLL---------EC----------VDVDECLDESNCRNGVCENTRGGYRCACTP 1064
               Y+G +          EC          +++DEC          C +   GYRC+C P
Sbjct: 796  LPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSC-P 854

Query: 1065 PAEYSPA-------QRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWV---- 1113
            P    P         R C S              C   RC++     R +C   W     
Sbjct: 855  PGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD----GRRDCSKVWCGWKP 910

Query: 1114 ------PGPSGRDCQLPESPAERAPER--RDVC--WSQRGEDGMCAGPLAGPALTFDDCC 1163
                  P      C L +   E+AP +  R  C  W + G +   + P    +   D+ C
Sbjct: 911  CLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970

Query: 1164 CR 1165
             R
Sbjct: 971  AR 972



 Score =  144 bits (364), Expect = 4e-34
 Identities = 180/694 (25%), Positives = 254/694 (36%), Gaps = 158/694 (22%)

Query: 654  GGRSCVD--LNECAKPHLCGDG-----GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDE 706
            G ++C+D  + +  K  +C  G     G C   PG  +C C  G++ +          DE
Sbjct: 227  GNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPG--ECRCSYGWQGRFC--------DE 275

Query: 707  CRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGAC-RDVNECAEGSPCSPGW-CENL-P 763
            C     C  G C      ++C  C+  +   GG  C +D+N C    PC+ G  C N  P
Sbjct: 276  CVPYPGCVHGSCVEP---WQC-NCETNW---GGLLCDKDLNYCGSHHPCTNGGTCINAEP 328

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRS 822
              +RCTC  GY+    GR+C   +     + C NG  C   P  F+C C SG+      +
Sbjct: 329  DQYRCTCPDGYS----GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS---GPT 381

Query: 823  HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGA 882
               DIDEC       GG C++    + C+CP+  + VG     D +EC   P  CL   +
Sbjct: 382  CALDIDECASNPCAAGGTCVDQVDGFECICPE--QWVGATCQLDANECEGKP--CLNAFS 437

Query: 883  CKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQEC 942
            CKNL G Y C C  G+                    C++N +D   C             
Sbjct: 438  CKNLIGGYYCDCIPGWKGIN----------------CHINVND---CRGQ---------- 468

Query: 943  CCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGS 1002
             C  G    D    Y C          +CP G G          G     + DEC    S
Sbjct: 469  -CQHGGTCKDLVNGYQC----------VCPRGFG----------GRHCELERDECA--SS 505

Query: 1003 EICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV-CENTRGGYRCA 1061
                 G C +   G+ C+C QGF   G L E VDVD C + S CRNG  C N  G Y CA
Sbjct: 506  PCHSGGLCEDLADGFHCHCPQGF--SGPLCE-VDVDLC-EPSPCRNGARCYNLEGDYYCA 561

Query: 1062 CTPPAEYSPAQRQCLSPEE-------MDVDECQDPAA-----------CRP-GRCVNLPG 1102
            C  P ++    + C  P E         +D C   A            C P GRCV+ PG
Sbjct: 562  C--PDDFGG--KNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 617

Query: 1103 -SYRCECRPPW--------VPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLA 1153
             ++ C C   +        +    G+ C+   +  +     R  C+   G +G       
Sbjct: 618  GNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFR--CFCPSGWEGELCD--T 673

Query: 1154 GPALTFDDCCCRQGRGW------------GAQCRPCPPRGAGSHCPTSQSESNSFWDTSP 1201
             P     D C  +GR +            G + + C  R       T  +    +     
Sbjct: 674  NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT 733

Query: 1202 LLLGKPPRDEDSSEEDSDECRCV------SGRCVPRPGGAVCECPGGFQLDASRARCVDI 1255
                 PP  + S+   +    C+       G CV       C C  G++    R    + 
Sbjct: 734  FRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNT 790

Query: 1256 DECRELNQRGLLCKSERCVNTSGSFRCVCKAGFA 1289
            ++C  L           CV+    FRC C  GFA
Sbjct: 791  NDCNPLP----CYNGGICVDGVNWFRCECAPGFA 820



 Score =  129 bits (325), Expect = 1e-29
 Identities = 169/665 (25%), Positives = 243/665 (36%), Gaps = 166/665 (24%)

Query: 678  NFPGHYKCN------CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQ 731
            +F GHY C+      C  G+  K  +  VC      +   +   G C   PG  +C    
Sbjct: 216  DFFGHYTCDQYGNKACMDGWMGKECKEAVC------KQGCNLLHGGC-TVPGECRC---- 264

Query: 732  PGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECE 790
              Y  QG    R  +EC     C  G C      ++C C   +     G  C  D++ C 
Sbjct: 265  -SYGWQG----RFCDECVPYPGCVHGSCVE---PWQCNCETNWG----GLLCDKDLNYCG 312

Query: 791  AGDVCDNG-ICSNT-PGSFQCQCLSGYHLSRDRSHCEDIDE-CDFPAACIGGDCINTNGS 847
            +   C NG  C N  P  ++C C  GY       +CE  +  C       GG C      
Sbjct: 313  SHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSG 368

Query: 848  YRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDE---GFTPTQD 903
            + C CP G     G  C  DIDEC+ +P  C   G C +    + C+C E   G T   D
Sbjct: 369  FECHCPSGW---SGPTCALDIDECASNP--CAAGGTCVDQVDGFECICPEQWVGATCQLD 423

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
             + CE        K C   F                   C +L  G+  +C+  P     
Sbjct: 424  ANECEG-------KPCLNAFS------------------CKNLIGGY--YCDCIP----- 451

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
                        G+         GI  H ++++C     +    G C +   GY+C C +
Sbjct: 452  ------------GWK--------GINCHINVNDCR---GQCQHGGTCKDLVNGYQCVCPR 488

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDV 1083
            GF   G   E ++ DEC        G+CE+   G+ C C P     P    C    E+DV
Sbjct: 489  GF--GGRHCE-LERDECASSPCHSGGLCEDLADGFHCHC-PQGFSGPL---C----EVDV 537

Query: 1084 DECQDPAACRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERR-DVCWSQ 1141
            D C+ P+ CR G RC NL G Y C C   +     G++C +P  P      R  D C S 
Sbjct: 538  DLCE-PSPCRNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGACRVIDGCGSD 592

Query: 1142 RGED--GMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDT 1199
             G    G  A  + GP      C  + G  +   C        G++C  +  +       
Sbjct: 593  AGPGMPGTAASGVCGP---HGRCVSQPGGNFSCIC---DSGFTGTYCHENIDDC------ 640

Query: 1200 SPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCEC-PGGFQLDA--SRARCVDID 1256
                LG+P R+  +  ++ D  RC    C     G +C+  P     D   SR RC D+ 
Sbjct: 641  ----LGQPCRNGGTCIDEVDAFRCF---CPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693

Query: 1257 E-----CRELNQRGLLCKSER-------------CVNTSGSFRCVCKAGFARS----RPH 1294
                  C +   +G  C S               C ++  +FRC C  G+  S      +
Sbjct: 694  NDFYCACDD-GWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKN 752

Query: 1295 GACVP 1299
             +C+P
Sbjct: 753  SSCLP 757



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 11/61 (18%)

Query: 114 PLPCMNGGQCSSRN---QCLCPPDFTGRFCQVPAGGAGGGT--------GGSGPGLSRTG 162
           P PC NG +C +      C CP DF G+ C VP     GG           +GPG+  T 
Sbjct: 542 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTA 601

Query: 163 A 163
           A
Sbjct: 602 A 602



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 43/179 (24%), Positives = 68/179 (37%), Gaps = 35/179 (19%)

Query: 289 CGSNPLPGL--TKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK 346
           CGS+  PG+  T     CG  G         +C       V +PG   G     C  G+ 
Sbjct: 589 CGSDAGPGMPGTAASGVCGPHG---------RC-------VSQPG---GNFSCICDSGF- 628

Query: 347 RLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCP---PGHSLGPSRTQCIADKPEEK 402
               T+C +  +  +   CR+G  C++   ++RC CP    G     +   C+ D    +
Sbjct: 629 --TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSR 686

Query: 403 SLCFRLVSPEH-QCQHPL--TTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
             C+ LV+  +  C       T  +R+  C +   + G  C     D    F+  CP G
Sbjct: 687 GRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY----DSGDTFRCACPPG 741



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 41/140 (29%), Positives = 55/140 (39%), Gaps = 27/140 (19%)

Query: 340 DCPQGYKRLNSTHCQ-DINECAMPGVCRHGD-CLNNPGSYRCVCP---PGHSLGPSRTQC 394
           DC  G+K +N   C  ++N+C   G C+HG  C +    Y+CVCP    G      R +C
Sbjct: 448 DCIPGWKGIN---CHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDEC 502

Query: 395 IADKPEEKSLCFRLVSPEH-QCQHPLTTRLTR---QLCCCSVGKAWGARCQR-------- 442
            +       LC  L    H  C    +  L      LC  S  +  GARC          
Sbjct: 503 ASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRN-GARCYNLEGDYYCA 561

Query: 443 CPTD----GTAAFKEICPAG 458
           CP D      +  +E CP G
Sbjct: 562 CPDDFGGKNCSVPREPCPGG 581



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 36/118 (30%), Positives = 50/118 (42%), Gaps = 20/118 (16%)

Query: 276 LGRCFQDTLPKQPCGSNPLPG-LTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
           +G+  ++ + KQ C  N L G  T   +C  S G  W    C +C       V  PG V 
Sbjct: 236 MGKECKEAVCKQGC--NLLHGGCTVPGECRCSYG--WQGRFCDEC-------VPYPGCVH 284

Query: 335 GEV----GADCPQGYKRLNSTHCQDINECAMPGVCRHGD-CLN-NPGSYRCVCPPGHS 386
           G        +C   +  L     +D+N C     C +G  C+N  P  YRC CP G+S
Sbjct: 285 GSCVEPWQCNCETNWGGLLCD--KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS 340



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 27/91 (29%), Positives = 32/91 (35%), Gaps = 15/91 (16%)

Query: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRG--------EVGADCPQGYKRLNSTHCQDINECA 360
           T WG   C K   L Y G   P    G        +    CP GY   N   C+      
Sbjct: 297 TNWGGLLCDK--DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN---CEKAEHAC 351

Query: 361 MPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 390
               C +G  C   P  + C CP G S GP+
Sbjct: 352 TSNPCANGGSCHEVPSGFECHCPSGWS-GPT 381



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 25/84 (29%), Positives = 34/84 (40%), Gaps = 17/84 (20%)

Query: 299 KQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINE 358
           K E  C S   A G S CH+ P    +G +            CP G+     T   DI+E
Sbjct: 346 KAEHACTSNPCANGGS-CHEVP----SGFE----------CHCPSGWS--GPTCALDIDE 388

Query: 359 CAMPGVCRHGDCLNNPGSYRCVCP 382
           CA       G C++    + C+CP
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICP 412



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 14/56 (25%)

Query: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGP 389
           G  G DC     R+N   CQ          C +G  C++    YRC CPPG + GP
Sbjct: 818 GFAGPDC-----RINIDECQS-------SPCAYGATCVDEINGYRCSCPPGRA-GP 860



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 14/74 (18%)

Query: 80  CRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQCSSRNQ--- 128
           CR  CQ G     +  NG+      G G R   C L        PC +GG C        
Sbjct: 465 CRGQCQHGGTCKDL-VNGYQCVCPRGFGGRH--CELERDECASSPCHSGGLCEDLADGFH 521

Query: 129 CLCPPDFTGRFCQV 142
           C CP  F+G  C+V
Sbjct: 522 CHCPQGFSGPLCEV 535



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 12/30 (40%), Positives = 17/30 (56%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCSSRN----QCLCPPDFTGRFCQ 141
           PC NGG C +      +C CP  ++GR C+
Sbjct: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCE 345



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 114 PLPCMNGGQC---SSRNQCLCPPDFTGRFCQV 142
           PLPC NGG C    +  +C C P F G  C++
Sbjct: 795 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRI 826



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 18/54 (33%), Positives = 21/54 (38%), Gaps = 11/54 (20%)

Query: 117 CMNGGQCSSRN---QCLCPPDFTGRFCQVPAGGA--------GGGTGGSGPGLS 159
           C NGG C       +C CPP + G  C V    +        GG   GSG   S
Sbjct: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 774



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 18/122 (14%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
           C  G++    TH  + N+C        G C++    +RC C PG + GP    C  +  E
Sbjct: 777 CRDGWEGRTCTH--NTNDCNPLPCYNGGICVDGVNWFRCECAPGFA-GP---DCRINIDE 830

Query: 401 EKSLCFRLVSPEHQCQHPLT--TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
            +S      SP   C +  T    +    C C  G+A G RCQ     G + +    P  
Sbjct: 831 CQS------SP---CAYGATCVDEINGYRCSCPPGRA-GPRCQEVIGFGRSCWSRGTPFP 880

Query: 459 KG 460
            G
Sbjct: 881 HG 882


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  183 bits (464), Expect = 1e-45
 Identities = 113/367 (30%), Positives = 162/367 (44%), Gaps = 51/367 (13%)

Query: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG-RGI 631
           + DEC    + C     C   P  Y C C PGY+   + + C D++ECE +    G    
Sbjct: 33  DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHE 90

Query: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY 691
           C+N  G+Y C C  G+ L     G +C+D++EC + +  G    C+N  G Y+C C+ G+
Sbjct: 91  CINIPGNYRCTCFDGFML--AHDGHNCLDVDEC-QDNNGGCQQICVNAMGSYECQCHSGF 147

Query: 692 RLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR------------S 736
            L  ++       +E   C +        C   P       C+PG+             +
Sbjct: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCN 207

Query: 737 QGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFRCTC 770
            G G C+                      D   C E    + G C+    +     RC+C
Sbjct: 208 YGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSC 267

Query: 771 AQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC 830
             G+   PDG++C D++EC   +   +  C NT GSF+C C  GY L  D   C+DIDEC
Sbjct: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327

Query: 831 DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890
            F   C    CIN+ GS++CLC +G+ L G   C D+DECS     C     C N +GSY
Sbjct: 328 SFERTC-DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSY 384

Query: 891 VCVCDEG 897
            CVC  G
Sbjct: 385 ECVCPPG 391



 Score =  170 bits (431), Expect = 7e-42
 Identities = 112/349 (32%), Positives = 155/349 (44%), Gaps = 61/349 (17%)

Query: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
           Q  + DEC  +     C H EC+  P +Y C C  G+        C+DV+EC+ +  G  
Sbjct: 71  QCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGC 128

Query: 629 RGICMNTGGSYNCHCNRGYRL--------HVGAGGRSCVDLNECAKPHLCGDGGFCINFP 680
           + IC+N  GSY C C+ G+ L        H    G +C++     K H C     C   P
Sbjct: 129 QQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMN-----KDHGCAH--ICRETP 181

Query: 681 -GHYKCNCYPGYRLKASRPPV--------------CED---------------------- 703
            G   C+C PG+ L  ++                 CED                      
Sbjct: 182 KGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241

Query: 704 IDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSPGWCENL 762
           I+ C   +   D  C++     +C +C  G+  Q  G  C+D+NEC   +     +C N 
Sbjct: 242 IETCAVNNGGCDRTCKDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300

Query: 763 PGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
            GSF C C +GY    D R+C D+DEC     CD+ IC N+PGSFQC C  GY L    +
Sbjct: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILY-GTT 358

Query: 823 HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDEC 870
           HC D+DEC          C+NT GSY C+CP G RL   G+ C +  +C
Sbjct: 359 HCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407



 Score =  150 bits (378), Expect = 1e-35
 Identities = 135/503 (26%), Positives = 196/503 (38%), Gaps = 88/503 (17%)

Query: 648  RLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDE 706
            RL  G+G    VD++EC++    C     C N P  YKC C PGY+ +  +   CEDIDE
Sbjct: 21   RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ---CEDIDE 77

Query: 707  CRDP---SSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
            C +      C   +C N PG+++C        +  G  C DV+EC + +      C N  
Sbjct: 78   CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAM 136

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVC---DNG---ICSNTP-GSFQCQCLSGYH 816
            GS+ C C  G+  + +  +C  +     G  C   D+G   IC  TP G   C C  G+ 
Sbjct: 137  GSYECQCHSGFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD 194

Query: 817  LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875
            L++++  C     C++        C +T+    C C Q + L   GR C  I+ C+ +  
Sbjct: 195  LAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNG 250

Query: 876  LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935
             C     CK+      C C  GFT   D   C+++       EC +N      CD     
Sbjct: 251  GC--DRTCKDTATGVRCSCPVGFTLQPDGKTCKDI------NECLVNNGG---CDHFCRN 299

Query: 936  NVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
             V   EC C  G              Y        C D                    ID
Sbjct: 300  TVGSFECGCRKG--------------YKLLTDERTCQD--------------------ID 325

Query: 996  ECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENT 1054
            EC     E   +  C+N+   ++C C +G+   G    C DVDEC +   +C  G C NT
Sbjct: 326  ECSF---ERTCDHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQG-CVNT 380

Query: 1055 RGGYRCACTPPAEYSPAQRQCL-----------SPE-EMDVDECQDPAAC---RPGRCVN 1099
            +G Y C C P        + C+           SP  ++   +     +C    P   + 
Sbjct: 381  KGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLF 440

Query: 1100 LPGSYRCECRPPWVPGPSGRDCQ 1122
            +P S         VPGP G+  Q
Sbjct: 441  VPDSENSYVLSCGVPGPQGKALQ 463



 Score =  104 bits (260), Expect = 5e-22
 Identities = 60/182 (32%), Positives = 84/182 (46%), Gaps = 10/182 (5%)

Query: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
           + C +N   C    C        C C  G+   P  + C D+NEC     G     C NT
Sbjct: 243 ETCAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNT 300

Query: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKA 695
            GS+ C C +GY+L      R+C D++EC+    C     CIN PG ++C C+ GY L  
Sbjct: 301 VGSFECGCRKGYKLLTDE--RTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYG 356

Query: 696 SRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPC 754
           +    C D+DEC   +   D  C N  GS++C+ C PG R    G  C +  +C   +  
Sbjct: 357 TTH--CGDVDECSMSNGSCDQGCVNTKGSYECV-CPPGRRLHWNGKDCVETGKCLSRAKT 413

Query: 755 SP 756
           SP
Sbjct: 414 SP 415



 Score =  103 bits (257), Expect = 1e-21
 Identities = 95/315 (30%), Positives = 119/315 (37%), Gaps = 42/315 (13%)

Query: 987  GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
            G+P   D+DEC     +   +  C NT   Y+C CK G  Y G   +C D+DEC  E++ 
Sbjct: 27   GLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDEC--ENDY 82

Query: 1047 RNG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPG 1102
             NG     C N  G YRC C      +     CL     DVDECQD        CVN  G
Sbjct: 83   YNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL-----DVDECQDNNGGCQQICVNAMG 137

Query: 1103 SYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC-AGPLAGPALTFDD 1161
            SY C+C   +    +   C        R+ E  +      G   +C   P  G A     
Sbjct: 138  SYECQCHSGFFLSDNQHTC------IHRSNEGMNCMNKDHGCAHICRETPKGGVA----- 186

Query: 1162 CCCRQGRGWGAQCRPCP---PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1218
            C CR G       + C      G G  C  S  ++    DT P           S     
Sbjct: 187  CDCRPGFDLAQNQKDCTLTCNYGNGG-CQHSCEDT----DTGPTCGCHQKYALHSDGRTC 241

Query: 1219 DECRCVSG-----RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1273
             E   V+       C     G  C CP GF L      C DI+EC  +N  G       C
Sbjct: 242  IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECL-VNNGGC---DHFC 297

Query: 1274 VNTSGSFRCVCKAGF 1288
             NT GSF C C+ G+
Sbjct: 298  RNTVGSFECGCRKGY 312



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 116/513 (22%), Positives = 180/513 (35%), Gaps = 95/513 (18%)

Query: 290 GSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN 349
           G + LPG    ++C          + C   P+  Y  + KPG  +GE             
Sbjct: 24  GGSGLPGSVDVDECSEGTDDCHIDAICQNTPK-SYKCLCKPG-YKGE------------- 68

Query: 350 STHCQDINECAMP---GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKPEE---- 401
              C+DI+EC      G C H +C+N PG+YRC C  G  L      C+  D+ ++    
Sbjct: 69  GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127

Query: 402 -KSLCFRLV-SPEHQC---------QHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450
            + +C   + S E QC         QH    R    + C +        C+  P  G A 
Sbjct: 128 CQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA- 186

Query: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEER 510
               C    G+ +  + +  T+          H              +   P     ++ 
Sbjct: 187 ----CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC----------EDTDTGPTCGCHQKY 232

Query: 511 GVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
            + +D     E     +     T          S P   T++      P  ++  +I   
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ------PDGKTCKDINEC 286

Query: 571 QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGR 629
            V         +N  G  EC          C  GY+     R C D++EC  E  C    
Sbjct: 287 LVNNGGCDHFCRNTVGSFEC---------GCRKGYKLLTDERTCQDIDECSFERTCD--- 334

Query: 630 GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
            IC+N+ GS+ C C+RGY L+   G   C D++EC+  +   D G C+N  G Y+C C P
Sbjct: 335 HICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPP 390

Query: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
           G RL  +         +C +   C      +      C        S+ GG    V  C 
Sbjct: 391 GRRLHWNG-------KDCVETGKCLSRAKTSPRAQLSC--------SKAGG----VESCF 431

Query: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
              P    +  +   S+  +C     P P G++
Sbjct: 432 LSCPAHTLFVPDSENSYVLSCG---VPGPQGKA 461



 Score = 87.4 bits (215), Expect = 8e-17
 Identities = 88/344 (25%), Positives = 119/344 (34%), Gaps = 75/344 (21%)

Query: 993  DIDECMLFGSEICKEG---KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049
            DIDEC    ++    G   +C+N    Y C C  GF    +   C+DVDEC D +     
Sbjct: 74   DIDECE---NDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130

Query: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP-GSYRCEC 1108
            +C N  G Y C C      S  Q  C+      ++       C    C   P G   C+C
Sbjct: 131  ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGC-AHICRETPKGGVACDC 189

Query: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ-- 1166
            RP +    + +DC L  +            +   G    C     GP      C C Q  
Sbjct: 190  RPGFDLAQNQKDCTLTCN------------YGNGGCQHSCEDTDTGPT-----CGCHQKY 232

Query: 1167 -----GRGWGAQC--------RPCPPRGAGSHCP-----TSQSESNSFWDTSPLLLGKPP 1208
                 GR     C        R C     G  C      T Q +  +  D +  L+    
Sbjct: 233  ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG 292

Query: 1209 RD----------------------EDSSEEDSDEC---RCVSGRCVPRPGGAVCECPGGF 1243
             D                      ++ + +D DEC   R     C+  PG   C C  G+
Sbjct: 293  CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGY 352

Query: 1244 QLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
             L  +   C D+DEC   N     C  + CVNT GS+ CVC  G
Sbjct: 353  ILYGT-THCGDVDECSMSNGS---C-DQGCVNTKGSYECVCPPG 391



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 38/117 (32%), Positives = 52/117 (44%), Gaps = 14/117 (11%)

Query: 281 QDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGA 339
           ++T+    CG      L   E  C  I     +  C H C       +  PG  +     
Sbjct: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHIC-------INSPGSFQ----C 346

Query: 340 DCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
            C +GY    +THC D++EC+M  G C  G C+N  GSY CVCPPG  L  +   C+
Sbjct: 347 LCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 5/94 (5%)

Query: 1205 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
            GK   D D  E D     CV   C+  PG   C C  GF L      C+D+DEC++ N  
Sbjct: 69   GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127

Query: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
               C+ + CVN  GS+ C C +GF  S     C+
Sbjct: 128  ---CQ-QICVNAMGSYECQCHSGFFLSDNQHTCI 157



 Score = 38.1 bits (87), Expect = 0.055
 Identities = 40/150 (26%), Positives = 56/150 (37%), Gaps = 36/150 (24%)

Query: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG---RS 782
           KC+AC PG    G     ++ +C     C PG  +++ G   CT      P+ DG     
Sbjct: 629 KCVACGPGTHFGG-----ELGQCVS---CMPGTYQDMEGQLSCT----PCPSSDGLGLPG 676

Query: 783 CLDVDECEAGDVCDNGICSNTPGSFQCQC--LSGYHLSRDRSHC--------------ED 826
             +V EC  G  C  G  S   G   CQ   +  Y     R+ C                
Sbjct: 677 ARNVSEC--GGQCSPGFFS-ADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTS 733

Query: 827 IDECDFPAACIGGDCINTNGSYRCL-CPQG 855
             +C+    C  G   NT  ++RC+ CP G
Sbjct: 734 FQDCEAKVHCSPGHHYNTT-THRCIRCPVG 762



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 38/169 (22%), Positives = 56/169 (33%), Gaps = 30/169 (17%)

Query: 668 HLCGDGGFCIN-FPGHYK-----CNCYPGYRLKASRPPVCEDIDECRDPSS--------- 712
           H  G+ G C++  PG Y+      +C P         P   ++ EC    S         
Sbjct: 638 HFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697

Query: 713 -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGW--------C 759
                CP G  + +PG   C  C  G  ++  G      +C     CSPG         C
Sbjct: 698 KPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT-TSFQDCEAKVHCSPGHHYNTTTHRC 756

Query: 760 ENLP-GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
              P G+++    Q +     G +  D D       C N  C    G +
Sbjct: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY 805


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  182 bits (461), Expect = 2e-45
 Identities = 130/452 (28%), Positives = 182/452 (40%), Gaps = 60/452 (13%)

Query: 675  FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
            FCIN PG Y C C  GY L + +   C   D C       +  C N PGSF C  C  GY
Sbjct: 252  FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309

Query: 735  R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
              ++ G  C  V+ CA  +      C N  GS+ C C +G+A  PD ++C  +D C + +
Sbjct: 310  ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
                  C NT  S+ C CL G+ L+ D+  C  I+ C         +C+N   SY C C 
Sbjct: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429

Query: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
            +G+ L   G+ C  +D C+Q    C     C N + S+VC C EGF   +D   C  V+ 
Sbjct: 430  RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
                  C L+                             DH   Y C V     F   CP
Sbjct: 488  ------CLLS-----------------------------DHGCEYSC-VNMDRSFACQCP 511

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY--DGN 1030
            +G     D             +D C L G   C E  CV+++  + C C +G+    DG 
Sbjct: 512  EGHVLRSDGKTC-------AKLDSCAL-GDHGC-EHSCVSSEDSFVCQCFEGYILREDGK 562

Query: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA 1090
                 DV + +D   C + +C N+   Y C C      +   ++C        D C+   
Sbjct: 563  TCRRKDVCQAIDH-GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-----DVCKSTH 615

Query: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ 1122
                  CVN   SY C+C   +V    GR C+
Sbjct: 616  HGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647



 Score =  176 bits (446), Expect = 1e-43
 Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)

Query: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
           C   ++ C H  C+  P  Y C C  GY  +     C   + C  E     + +C+N  G
Sbjct: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299

Query: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
           S+ C C  GY L     G+ CV ++ CA + H C     C+N  G Y C C+ G+ L   
Sbjct: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355

Query: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756
           +   C  ID C   +     +C N   S+ C   +    +     CR +N CA   P   
Sbjct: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414

Query: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816
             C N+  S+ C C +GY   P+G++C  VD C   D     +C NT  SF CQC  G+ 
Sbjct: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474

Query: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875
           ++ D   C  +D C          C+N + S+ C CP+GH L   G+ C  +D C+    
Sbjct: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534

Query: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930
            C    +C + + S+VC C EG+   +D   C   +      H  +   +N DD+  C+
Sbjct: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591



 Score =  171 bits (434), Expect = 3e-42
 Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)

Query: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
           D C    + C H ECV     Y C C+ G+  +P  + C  ++ C +   G  +  C+NT
Sbjct: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379

Query: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693
             SY+CHC +G+ L+     ++C  +N CA  KP   G    C+N    Y C C+ GY L
Sbjct: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434

Query: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752
             +    C  +D C       +  C N   SF C  C  G+  ++    C  V+ C    
Sbjct: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492

Query: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812
                 C N+  SF C C +G+    DG++C  +D C  GD      C ++  SF CQC 
Sbjct: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552

Query: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871
            GY L  D   C   D C          C+N++ SY C C +G RL   G++C+  D C 
Sbjct: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612

Query: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909
                C     C N   SY+C C EGF   +D   C++
Sbjct: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648



 Score =  152 bits (384), Expect = 2e-36
 Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)

Query: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
           T+ D C  + + C H ECV     YSCHC  G+  +P  + C  +N C     G     C
Sbjct: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417

Query: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691
           +N   SY C C+RGY L     G++C  ++ CA + H C     C+N    + C C  G+
Sbjct: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473

Query: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751
            +       C  +D C       +  C N   SF C   +       G  C  ++ CA G
Sbjct: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532

Query: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811
                  C +   SF C C +GY    DG++C   D C+A D     IC N+  S+ C+C
Sbjct: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592

Query: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870
           L G+ L+ D   C   D C          C+N   SY C C +G  L   GR+C+   +C
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649

Query: 871 SQDP 874
           ++ P
Sbjct: 650 TEGP 653



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 104/454 (22%), Positives = 150/454 (33%), Gaps = 99/454 (21%)

Query: 883  CKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQEC 942
            C N+ GSYVC C +G+    DQ  C   +                 C   +  +  +Q C
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQD----------------LC--AMEDHNCEQLC 294

Query: 943  CCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGS 1002
                G+        + C  YS    ++L  DGK                  +D C     
Sbjct: 295  VNVPGS--------FVCQCYSG---YALAEDGKRCVA--------------VDYCASENH 329

Query: 1003 EICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062
                E +CVN    Y C C +GF  + +   C  +D C   ++     C NT   Y C C
Sbjct: 330  GC--EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHC 387

Query: 1063 TPPAEYSPAQRQCLSPEEMDVDECQDPAACRPG---RCVNLPGSYRCECRPPWVPGPSGR 1119
                  +P ++ C       ++ C   A  +PG    CVN+  SY C C   +   P+G+
Sbjct: 388  LKGFTLNPDKKTCRR-----INYC---ALNKPGCEHECVNMEESYYCRCHRGYTLDPNGK 439

Query: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFD-------DCCCRQGRGWGA 1172
             C   +  A++      +C +   ED        G  +  D       D C     G   
Sbjct: 440  TCSRVDHCAQQDHGCEQLCLNT--EDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY 497

Query: 1173 QCRPCPPRGAGSHCPTS---QSESNSFWDTSPLLLGKPPRDEDS-SEEDSDECRCVSGR- 1227
             C     R     CP     +S+  +        LG    +    S EDS  C+C  G  
Sbjct: 498  SCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556

Query: 1228 ------------------------CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1263
                                    CV       CEC  GF+L     RC   D C+  + 
Sbjct: 557  LREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHH 616

Query: 1264 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
                C+   CVN   S+ C C  GF  +     C
Sbjct: 617  G---CE-HICVNNGNSYICKCSEGFVLAEDGRRC 646



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374
           H C  L++        + G     C QGY  LNS  T C+  + CAM        C+N P
Sbjct: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298

Query: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434
           GS+ C C  G++L     +C+A        C    S  H C+H         LC C  G 
Sbjct: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350

Query: 435 AWGARCQRC 443
           A     + C
Sbjct: 351 ALNPDKKTC 359



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)

Query: 1228 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
            C+  PG  VC C  G+ L++ +  C   D C   +     C+ + CVN  GSF C C +G
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308

Query: 1288 FARSRPHGACV 1298
            +A +     CV
Sbjct: 309  YALAEDGKRCV 319



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374
           H C QL          V G     C  GY    +   C  ++ CA     C H +C+N  
Sbjct: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339

Query: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           GSY C C  G +L P +  C      +   C    S  H CQH          C C  G
Sbjct: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           C +GY  R +   C+  + C A+   C H  C+N+  SY C C  G  L     +C    
Sbjct: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447
              K +C    S  H C+H         +C CS G      G RC++C T+G
Sbjct: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)

Query: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
           C+ IN CA+  PG C H +C+N   SY C C  G++L P+   C        S       
Sbjct: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449

Query: 411 PEHQCQHPLTTRLTRQLCCCSVG 433
            +H C+          +C CS G
Sbjct: 450 QDHGCEQLCLNTEDSFVCQCSEG 472



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)

Query: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369
           +C  + Y   +  G     V AD      C +G+    +   C  I+ CA     C+H +
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375

Query: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394
           C+N   SY C C  G +L P +  C
Sbjct: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)

Query: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           CP+G+  R +   C  ++ CA+    C H  C+++  S+ C C  G+ L      C    
Sbjct: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442
              K +C  +   +H C+H          C C  G      G RC+R
Sbjct: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)

Query: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
           +D+  C+    C   D      C+N   S+ C CP GH L      C   K +  +L   
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531

Query: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457
               +H C+H   +     +C C  G   +  G  C+R         K++C A
Sbjct: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)

Query: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371
           C ++ Y  + KPG     V  +      C +GY    N   C  ++ CA         CL
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459

Query: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431
           N   S+ C C  G  +      C         + + L+S +H C++          C C 
Sbjct: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511

Query: 432 VG 433
            G
Sbjct: 512 EG 513


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  182 bits (461), Expect = 2e-45
 Identities = 130/452 (28%), Positives = 182/452 (40%), Gaps = 60/452 (13%)

Query: 675  FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
            FCIN PG Y C C  GY L + +   C   D C       +  C N PGSF C  C  GY
Sbjct: 252  FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309

Query: 735  R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
              ++ G  C  V+ CA  +      C N  GS+ C C +G+A  PD ++C  +D C + +
Sbjct: 310  ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
                  C NT  S+ C CL G+ L+ D+  C  I+ C         +C+N   SY C C 
Sbjct: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429

Query: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
            +G+ L   G+ C  +D C+Q    C     C N + S+VC C EGF   +D   C  V+ 
Sbjct: 430  RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
                  C L+                             DH   Y C V     F   CP
Sbjct: 488  ------CLLS-----------------------------DHGCEYSC-VNMDRSFACQCP 511

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY--DGN 1030
            +G     D             +D C L G   C E  CV+++  + C C +G+    DG 
Sbjct: 512  EGHVLRSDGKTC-------AKLDSCAL-GDHGC-EHSCVSSEDSFVCQCFEGYILREDGK 562

Query: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA 1090
                 DV + +D   C + +C N+   Y C C      +   ++C        D C+   
Sbjct: 563  TCRRKDVCQAIDH-GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-----DVCKSTH 615

Query: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ 1122
                  CVN   SY C+C   +V    GR C+
Sbjct: 616  HGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647



 Score =  176 bits (446), Expect = 1e-43
 Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)

Query: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
           C   ++ C H  C+  P  Y C C  GY  +     C   + C  E     + +C+N  G
Sbjct: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299

Query: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
           S+ C C  GY L     G+ CV ++ CA + H C     C+N  G Y C C+ G+ L   
Sbjct: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355

Query: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756
           +   C  ID C   +     +C N   S+ C   +    +     CR +N CA   P   
Sbjct: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414

Query: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816
             C N+  S+ C C +GY   P+G++C  VD C   D     +C NT  SF CQC  G+ 
Sbjct: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474

Query: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875
           ++ D   C  +D C          C+N + S+ C CP+GH L   G+ C  +D C+    
Sbjct: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534

Query: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930
            C    +C + + S+VC C EG+   +D   C   +      H  +   +N DD+  C+
Sbjct: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591



 Score =  171 bits (434), Expect = 3e-42
 Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)

Query: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
           D C    + C H ECV     Y C C+ G+  +P  + C  ++ C +   G  +  C+NT
Sbjct: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379

Query: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693
             SY+CHC +G+ L+     ++C  +N CA  KP   G    C+N    Y C C+ GY L
Sbjct: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434

Query: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752
             +    C  +D C       +  C N   SF C  C  G+  ++    C  V+ C    
Sbjct: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492

Query: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812
                 C N+  SF C C +G+    DG++C  +D C  GD      C ++  SF CQC 
Sbjct: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552

Query: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871
            GY L  D   C   D C          C+N++ SY C C +G RL   G++C+  D C 
Sbjct: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612

Query: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909
                C     C N   SY+C C EGF   +D   C++
Sbjct: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648



 Score =  152 bits (384), Expect = 2e-36
 Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)

Query: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
           T+ D C  + + C H ECV     YSCHC  G+  +P  + C  +N C     G     C
Sbjct: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417

Query: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691
           +N   SY C C+RGY L     G++C  ++ CA + H C     C+N    + C C  G+
Sbjct: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473

Query: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751
            +       C  +D C       +  C N   SF C   +       G  C  ++ CA G
Sbjct: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532

Query: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811
                  C +   SF C C +GY    DG++C   D C+A D     IC N+  S+ C+C
Sbjct: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592

Query: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870
           L G+ L+ D   C   D C          C+N   SY C C +G  L   GR+C+   +C
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649

Query: 871 SQDP 874
           ++ P
Sbjct: 650 TEGP 653



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 104/454 (22%), Positives = 150/454 (33%), Gaps = 99/454 (21%)

Query: 883  CKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQEC 942
            C N+ GSYVC C +G+    DQ  C   +                 C   +  +  +Q C
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQD----------------LC--AMEDHNCEQLC 294

Query: 943  CCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGS 1002
                G+        + C  YS    ++L  DGK                  +D C     
Sbjct: 295  VNVPGS--------FVCQCYSG---YALAEDGKRCVA--------------VDYCASENH 329

Query: 1003 EICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062
                E +CVN    Y C C +GF  + +   C  +D C   ++     C NT   Y C C
Sbjct: 330  GC--EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHC 387

Query: 1063 TPPAEYSPAQRQCLSPEEMDVDECQDPAACRPG---RCVNLPGSYRCECRPPWVPGPSGR 1119
                  +P ++ C       ++ C   A  +PG    CVN+  SY C C   +   P+G+
Sbjct: 388  LKGFTLNPDKKTCRR-----INYC---ALNKPGCEHECVNMEESYYCRCHRGYTLDPNGK 439

Query: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFD-------DCCCRQGRGWGA 1172
             C   +  A++      +C +   ED        G  +  D       D C     G   
Sbjct: 440  TCSRVDHCAQQDHGCEQLCLNT--EDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY 497

Query: 1173 QCRPCPPRGAGSHCPTS---QSESNSFWDTSPLLLGKPPRDEDS-SEEDSDECRCVSGR- 1227
             C     R     CP     +S+  +        LG    +    S EDS  C+C  G  
Sbjct: 498  SCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556

Query: 1228 ------------------------CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1263
                                    CV       CEC  GF+L     RC   D C+  + 
Sbjct: 557  LREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHH 616

Query: 1264 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
                C+   CVN   S+ C C  GF  +     C
Sbjct: 617  G---CE-HICVNNGNSYICKCSEGFVLAEDGRRC 646



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374
           H C  L++        + G     C QGY  LNS  T C+  + CAM        C+N P
Sbjct: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298

Query: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434
           GS+ C C  G++L     +C+A        C    S  H C+H         LC C  G 
Sbjct: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350

Query: 435 AWGARCQRC 443
           A     + C
Sbjct: 351 ALNPDKKTC 359



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)

Query: 1228 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
            C+  PG  VC C  G+ L++ +  C   D C   +     C+ + CVN  GSF C C +G
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308

Query: 1288 FARSRPHGACV 1298
            +A +     CV
Sbjct: 309  YALAEDGKRCV 319



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374
           H C QL          V G     C  GY    +   C  ++ CA     C H +C+N  
Sbjct: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339

Query: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           GSY C C  G +L P +  C      +   C    S  H CQH          C C  G
Sbjct: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           C +GY  R +   C+  + C A+   C H  C+N+  SY C C  G  L     +C    
Sbjct: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447
              K +C    S  H C+H         +C CS G      G RC++C T+G
Sbjct: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)

Query: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
           C+ IN CA+  PG C H +C+N   SY C C  G++L P+   C        S       
Sbjct: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449

Query: 411 PEHQCQHPLTTRLTRQLCCCSVG 433
            +H C+          +C CS G
Sbjct: 450 QDHGCEQLCLNTEDSFVCQCSEG 472



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)

Query: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369
           +C  + Y   +  G     V AD      C +G+    +   C  I+ CA     C+H +
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375

Query: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394
           C+N   SY C C  G +L P +  C
Sbjct: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)

Query: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           CP+G+  R +   C  ++ CA+    C H  C+++  S+ C C  G+ L      C    
Sbjct: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442
              K +C  +   +H C+H          C C  G      G RC+R
Sbjct: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)

Query: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
           +D+  C+    C   D      C+N   S+ C CP GH L      C   K +  +L   
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531

Query: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457
               +H C+H   +     +C C  G   +  G  C+R         K++C A
Sbjct: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)

Query: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371
           C ++ Y  + KPG     V  +      C +GY    N   C  ++ CA         CL
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459

Query: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431
           N   S+ C C  G  +      C         + + L+S +H C++          C C 
Sbjct: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511

Query: 432 VG 433
            G
Sbjct: 512 EG 513


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.139    0.476 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,223,040
Number of Sequences: 37866
Number of extensions: 5012599
Number of successful extensions: 40783
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 673
Number of HSP's that attempted gapping in prelim test: 21952
Number of HSP's gapped (non-prelim): 8734
length of query: 1303
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1189
effective length of database: 13,930,794
effective search space: 16563714066
effective search space used: 16563714066
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.