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Search of human proteins with 18874090
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18874090 WD repeat domain 48 [Homo sapiens]
(677 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18874090 WD repeat domain 48 [Homo sapiens] 1389 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 112 1e-24
gi|16554627 WD repeat domain 5 [Homo sapiens] 112 1e-24
gi|23199987 WD repeat domain 5B [Homo sapiens] 111 2e-24
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 111 2e-24
gi|26665869 WD repeat domain 51B [Homo sapiens] 100 6e-21
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 99 1e-20
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 99 1e-20
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 99 1e-20
gi|19913369 transducin beta-like 3 [Homo sapiens] 96 8e-20
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 96 1e-19
gi|157266266 WD repeat domain 86 [Homo sapiens] 96 1e-19
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 95 2e-19
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 95 2e-19
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 95 2e-19
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 93 7e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 93 7e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 93 7e-19
gi|32189425 WD repeat domain 69 [Homo sapiens] 93 9e-19
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 92 2e-18
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 91 3e-18
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 91 3e-18
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 87 5e-17
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 86 9e-17
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 86 9e-17
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 86 9e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 86 1e-16
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 85 2e-16
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 83 7e-16
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 82 1e-15
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 1389 bits (3594), Expect = 0.0
Identities = 677/677 (100%), Positives = 677/677 (100%)
Query: 1 MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN 60
MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN
Sbjct: 1 MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN 60
Query: 61 QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV 120
QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV
Sbjct: 61 QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV 120
Query: 121 KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG 180
KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG
Sbjct: 121 KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG 180
Query: 181 TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240
TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG
Sbjct: 181 TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240
Query: 241 QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM 300
QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM
Sbjct: 241 QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM 300
Query: 301 ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG 360
ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG
Sbjct: 301 ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG 360
Query: 361 ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF 420
ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF
Sbjct: 361 ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF 420
Query: 421 SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN 480
SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN
Sbjct: 421 SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN 480
Query: 481 PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM 540
PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM
Sbjct: 481 PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM 540
Query: 541 LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV 600
LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV
Sbjct: 541 LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV 600
Query: 601 YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF 660
YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF
Sbjct: 601 YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF 660
Query: 661 IWKSGGDLTLHYRQKST 677
IWKSGGDLTLHYRQKST
Sbjct: 661 IWKSGGDLTLHYRQKST 677
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 112 bits (279), Expect = 1e-24
Identities = 69/277 (24%), Positives = 133/277 (48%), Gaps = 19/277 (6%)
Query: 15 VQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHH 74
V+ +Y ++ + + + V++++ P L ++ D +I+IW K + I+ H
Sbjct: 31 VKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG---H 86
Query: 75 TDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134
++D+ + L+SAS D T+K+W+ G C+ TL+ H +YV + L+ S
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 135 AGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRV 194
D + +WDV T L +L + D + ++ N+ G++IVS S + + R+
Sbjct: 147 GSFDESVRIWDVKTGKCL---------KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 195 WDPRTCAKLMKLKGHTDN--VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHD 252
WD + + +K DN V + + +G L+ + D T++LW + +C+ TY H
Sbjct: 198 WDTAS-GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 253 EGVWALQVNDAFT---HVYSGGRDRKIYCTDLRNPDI 286
+ + N + T + SG D +Y +L+ +I
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Score = 76.3 bits (186), Expect = 9e-14
Identities = 61/249 (24%), Positives = 108/249 (43%), Gaps = 50/249 (20%)
Query: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN----G 87
G++ + N L +A D ++IW V+ K + +++ H+++V CCN
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYV----FCCNFNPQS 141
Query: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147
++S S D +V++W+ G C+ TL H D V A+ + +D L+ S+ D +WD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 148 T--------------------------LTALTASNNTVT--------TSSLSGNKDSIYS 173
+ + A T N + +G+K+ Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 174 LAMNQL---GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGS- 229
+ N G IVSGS + ++ +W+ +T + KL+GHTD V + + S +
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 230 -SDGTIRLW 237
+D TI+LW
Sbjct: 322 ENDKTIKLW 330
Score = 73.6 bits (179), Expect = 6e-13
Identities = 53/214 (24%), Positives = 98/214 (45%), Gaps = 13/214 (6%)
Query: 112 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSI 171
TL H V ++ ++ + E +AS+ D+ I +W + + ++SG+K I
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW---------GAYDGKFEKTISGHKLGI 90
Query: 172 YSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 231
+A + ++VS S +K L++WD + L LKGH++ V N +SGS D
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLI 290
++R+W + +C+ T H + V A+ N + + S D D + ++ LI
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 291 CEEKAPVLKMELDRSADPPPAIWVATTKSTVNKW 324
++ PV ++ + I AT +T+ W
Sbjct: 211 DDDNPPVSFVKFSPNG---KYILAATLDNTLKLW 241
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 112 bits (279), Expect = 1e-24
Identities = 69/277 (24%), Positives = 133/277 (48%), Gaps = 19/277 (6%)
Query: 15 VQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHH 74
V+ +Y ++ + + + V++++ P L ++ D +I+IW K + I+ H
Sbjct: 31 VKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG---H 86
Query: 75 TDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134
++D+ + L+SAS D T+K+W+ G C+ TL+ H +YV + L+ S
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 135 AGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRV 194
D + +WDV T L +L + D + ++ N+ G++IVS S + + R+
Sbjct: 147 GSFDESVRIWDVKTGKCL---------KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 195 WDPRTCAKLMKLKGHTDN--VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHD 252
WD + + +K DN V + + +G L+ + D T++LW + +C+ TY H
Sbjct: 198 WDTAS-GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 253 EGVWALQVNDAFT---HVYSGGRDRKIYCTDLRNPDI 286
+ + N + T + SG D +Y +L+ +I
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Score = 76.3 bits (186), Expect = 9e-14
Identities = 61/249 (24%), Positives = 108/249 (43%), Gaps = 50/249 (20%)
Query: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN----G 87
G++ + N L +A D ++IW V+ K + +++ H+++V CCN
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYV----FCCNFNPQS 141
Query: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147
++S S D +V++W+ G C+ TL H D V A+ + +D L+ S+ D +WD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 148 T--------------------------LTALTASNNTVT--------TSSLSGNKDSIYS 173
+ + A T N + +G+K+ Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 174 LAMNQL---GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGS- 229
+ N G IVSGS + ++ +W+ +T + KL+GHTD V + + S +
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 230 -SDGTIRLW 237
+D TI+LW
Sbjct: 322 ENDKTIKLW 330
Score = 73.6 bits (179), Expect = 6e-13
Identities = 53/214 (24%), Positives = 98/214 (45%), Gaps = 13/214 (6%)
Query: 112 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSI 171
TL H V ++ ++ + E +AS+ D+ I +W + + ++SG+K I
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW---------GAYDGKFEKTISGHKLGI 90
Query: 172 YSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 231
+A + ++VS S +K L++WD + L LKGH++ V N +SGS D
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLI 290
++R+W + +C+ T H + V A+ N + + S D D + ++ LI
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 291 CEEKAPVLKMELDRSADPPPAIWVATTKSTVNKW 324
++ PV ++ + I AT +T+ W
Sbjct: 211 DDDNPPVSFVKFSPNG---KYILAATLDNTLKLW 241
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 111 bits (278), Expect = 2e-24
Identities = 69/259 (26%), Positives = 124/259 (47%), Gaps = 18/259 (6%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
V++++ P L ++ D +I IW K Y ++ H ++D+ + L+S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGK---YEKTLYGHNLEISDVAWSSDSSRLVS 100
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAL 152
AS D T+K+W+ G C+ TL+ H +YV + L+ S D + +W+V T L
Sbjct: 101 ASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL 160
Query: 153 TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN 212
+LS + D + ++ N G++IVSGS + + R+WD + + +K DN
Sbjct: 161 ---------KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS-GQCLKTLVDDDN 210
Query: 213 --VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT---HV 267
V + + +G L+ + D T++LW + RC+ TY H + + N + T +
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 268 YSGGRDRKIYCTDLRNPDI 286
SG D +Y +L+ +I
Sbjct: 271 VSGSEDNLVYIWNLQTKEI 289
Score = 97.4 bits (241), Expect = 4e-20
Identities = 56/196 (28%), Positives = 97/196 (49%), Gaps = 15/196 (7%)
Query: 58 SVNQHKQDP------YIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMS 111
S NQ K+ P ++ HT+ V+ + NG+ L S+S+D + +W A+ G
Sbjct: 18 SANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEK 77
Query: 112 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSI 171
TL H + +A++ D + SA D+ + LWDV + L +L G+ + +
Sbjct: 78 TLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCL---------KTLKGHSNYV 128
Query: 172 YSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 231
+ N +I+SGS ++ +++W+ +T L L H+D V A+ N G+ +SGS D
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
Query: 232 GTIRLWSLGQQRCIAT 247
G R+W +C+ T
Sbjct: 189 GLCRIWDAASGQCLKT 204
Score = 79.3 bits (194), Expect = 1e-14
Identities = 57/217 (26%), Positives = 104/217 (47%), Gaps = 18/217 (8%)
Query: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86
K + N V +P N + + D ++IW V K + ++ H+D V+ + C+
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK---CLKTLSAHSDPVSAVHFNCS 178
Query: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY-VKALAYAKDKELVASAGLDRQIFLWD 145
G ++S S D ++W+A G C+ TL + V + ++ + + + +A LD + LWD
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQL---GTIIVSGSTEKVLRVWDPRTCAK 202
+ L + +G+K+ Y + N G IVSGS + ++ +W+ +T
Sbjct: 239 YSRGRCL---------KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 289
Query: 203 LMKLKGHTDNVKALLLNRDGTQCLSGS--SDGTIRLW 237
+ KL+GHTD V + + S + +D TI+LW
Sbjct: 290 VQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 76.3 bits (186), Expect = 9e-14
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 13/214 (6%)
Query: 112 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSI 171
TL H + V ++ ++ + E +AS+ DR I +W + + +L G+ I
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---------GAYDGKYEKTLYGHNLEI 86
Query: 172 YSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 231
+A + + +VS S +K L++WD R+ L LKGH++ V N +SGS D
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLI 290
T+++W + +C+ T H + V A+ N + + + SG D D + ++ L+
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 291 CEEKAPVLKMELDRSADPPPAIWVATTKSTVNKW 324
++ PV ++ + I AT +T+ W
Sbjct: 207 DDDNPPVSFVKFSPNG---KYILTATLDNTLKLW 237
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
V+ ++ P + TA D+ +++W ++ + ++ + GK ++S
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGL--DRQIFLWDVN 147
S D V +WN + L+ H D V + A + L+ASA L D+ I LW N
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 111 bits (277), Expect = 2e-24
Identities = 69/267 (25%), Positives = 124/267 (46%), Gaps = 14/267 (5%)
Query: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86
K + + V + D + L + D I++W + I +M H V+ + + N
Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE---CIRTMHGHDHNVSSVAIMPN 203
Query: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
G ++SAS D T+K+W G+C+ T H+++V+ + +D L+AS D+ + +W V
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263
Query: 147 NTLTALTA-SNNTVTTSSLSGNKDSIYSLAMNQLGT----------IIVSGSTEKVLRVW 195
T + +S +S YS G+ ++SGS +K +++W
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 196 DPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGV 255
D T LM L GH + V+ +L + G LS + D T+R+W +RC+ T H+ V
Sbjct: 324 DVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383
Query: 256 WALQVNDAFTHVYSGGRDRKIYCTDLR 282
+L + +V +G D+ + + R
Sbjct: 384 TSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 68.9 bits (167), Expect = 1e-11
Identities = 36/114 (31%), Positives = 60/114 (52%)
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
+LSG++ + + + + +++VS S + ++VWD T LKGHTD+V+ + + G
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 276
S S+D TI+LW CI T HD V ++ + H+ S RD+ I
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
Score = 64.7 bits (156), Expect = 3e-10
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 28/230 (12%)
Query: 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIY 172
L H+ V + + ++ SA D I +WD T +L G+ DS+
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF---------ERTLKGHTDSVQ 154
Query: 173 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDG 232
++ + G ++ S S + +++WD + + + GH NV ++ + +G +S S D
Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
Query: 233 TIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYC---------TDLRN 283
TI++W + C+ T+ H E V ++ N T + S D+ + +LR
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
Query: 284 PDIRVLICEEKAP---------VLKMELDRSADPPPAIWVATTKSTVNKW 324
+ V+ C AP E +S P P + + T+ W
Sbjct: 275 HE-HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 100 bits (248), Expect = 6e-21
Identities = 60/248 (24%), Positives = 119/248 (47%), Gaps = 12/248 (4%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+++ V ++Q P N L +A RD +R+W ++ + + + HT V + +G+
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGK---FSEFKAHTAPVRSVDFSADGQ 115
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
L +AS D ++KVW+ ++ + +L H +V+ ++ D L+ S D+ I +WD
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
+ +++V ++ + N GT I S +++ ++VWD R L +
Sbjct: 176 KQCVNNFSDSVGFANF---------VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV 226
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
H+ V + + G ++ SSDGT+++ L + R I T + H V+ + +
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286
Query: 269 SGGRDRKI 276
SGG D ++
Sbjct: 287 SGGADTQV 294
Score = 85.9 bits (211), Expect = 1e-16
Identities = 63/285 (22%), Positives = 120/285 (42%), Gaps = 20/285 (7%)
Query: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQD-PYIASMEHHTDWVNDIVLCC 85
K ++ + +L L P +L TA D+ + +W+ H + Y+ H D V +
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG----HKDVVTSVQFSP 70
Query: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
+G L SAS D TV++W K S + H V+++ ++ D + +A+A D+ I +W
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 146 V---NTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK 202
+ L +L + V + S + G +IVS S +K +++WD
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPD------------GRLIVSCSEDKTIKIWDTTNKQC 178
Query: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262
+ + N GT S SD T+++W + + + Y+VH GV + +
Sbjct: 179 VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 263 AFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSAD 307
+ ++ + D + DL + + PV + + +
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGE 283
Score = 78.2 bits (191), Expect = 2e-14
Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 12/193 (6%)
Query: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104
L TA D I++WS+ + + ++ S+ HT WV +G+ ++S S D T+K+W+
Sbjct: 117 LATASEDKSIKVWSMYRQR---FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 105 HKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSL 164
C++ + + + +ASAG D+ + +WDV L
Sbjct: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL---------QHY 224
Query: 165 SGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQ 224
+ + ++ + G +++ S++ L++ D + L+GHT V + ++ G
Sbjct: 225 QVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
Query: 225 CLSGSSDGTIRLW 237
SG +D + LW
Sbjct: 285 FASGGADTQVLLW 297
Score = 64.3 bits (155), Expect = 3e-10
Identities = 37/114 (32%), Positives = 62/114 (54%), Gaps = 3/114 (2%)
Query: 34 NALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISA 93
N + +P+ + +AG D +++W V +K + + H+ VN I +G LI+A
Sbjct: 190 NFVDFNPSGTCIASAGSDQTVKVWDVRVNK---LLQHYQVHSGGVNCISFHPSGNYLITA 246
Query: 94 SSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147
SSD T+K+ + +G + TL+ H V ++++K EL AS G D Q+ LW N
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Score = 53.1 bits (126), Expect = 8e-07
Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 14/184 (7%)
Query: 153 TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN 212
+A+ + V G+K +I SL ++ G + + S + L +W+ + A+ + GH D
Sbjct: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62
Query: 213 VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVH-----------DEGVWALQVN 261
V ++ + G S S D T+RLW ++ + ++ H D A
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 262 DAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTV 321
D V+S R R +Y +R C + +P ++ + S D IW T K V
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVR---CAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 322 NKWT 325
N ++
Sbjct: 180 NNFS 183
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 99.0 bits (245), Expect = 1e-20
Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 12/248 (4%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+++ V + P+ + L + RD +RIW N + + HT V + C +G+
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQ 78
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
+ ++AS D TVKVW H+ + +L H ++V+ ++ D L+ SA D+ + LWD
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--- 135
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
++ S + + + + GT I + + ++VWD RT L +
Sbjct: 136 ------KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 189
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
H+ V L + G ++ SSD T+++ L + R + T H + + +
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249
Query: 269 SGGRDRKI 276
SGG D ++
Sbjct: 250 SGGSDEQV 257
Score = 84.7 bits (208), Expect = 3e-16
Identities = 47/191 (24%), Positives = 93/191 (48%), Gaps = 12/191 (6%)
Query: 47 TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHK 106
TA D +++W+ ++ K ++ S+ H +WV +G+ ++SAS D TVK+W+
Sbjct: 82 TASDDKTVKVWATHRQK---FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138
Query: 107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSG 166
C+ + H +V + + +A+AG+D + +WDV T L + + +++++G
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL--QHYQLHSAAVNG 196
Query: 167 NKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL 226
L+ + G +++ S++ L++ D L L GH + +R G
Sbjct: 197 -------LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249
Query: 227 SGSSDGTIRLW 237
SG SD + +W
Sbjct: 250 SGGSDEQVMVW 260
Score = 63.9 bits (154), Expect = 5e-10
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 5/128 (3%)
Query: 22 RDEVEKYNRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
R+ V Y +G V + P+ + AG D+ +++W V H+ + + H+ VN
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---LLQHYQLHSAAVN 195
Query: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDR 139
+ +G LI+ASSD+T+K+ + +G + TL H+ +A+++ E AS G D
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 255
Query: 140 QIFLWDVN 147
Q+ +W N
Sbjct: 256 QVMVWKSN 263
Score = 56.6 bits (135), Expect = 7e-08
Identities = 35/163 (21%), Positives = 73/163 (44%), Gaps = 3/163 (1%)
Query: 165 SGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQ 224
+G+KD++ + + G ++ SGS +K +R+W P + + HT V+++ DG
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 225 CLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNP 284
++ S D T+++W+ +Q+ + + H V + + + S D+ + D +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 285 DIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLK 327
+ CE V ++ S I A +TV W ++
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSG---TCIAAAGMDNTVKVWDVR 179
Score = 36.6 bits (83), Expect = 0.078
Identities = 31/148 (20%), Positives = 63/148 (42%), Gaps = 8/148 (5%)
Query: 189 EKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATY 248
+ L VW + ++ + GH D V + + G SGS D T+R+W + +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 249 RVHDEGVWALQ-VNDAFTHV-YSGGRDRKIYCTDLR------NPDIRVLICEEKAPVLKM 300
R H V ++ +D + V S + K++ T + + I + C + +P ++
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 301 ELDRSADPPPAIWVATTKSTVNKWTLKG 328
+ S D +W +++ V+ + G
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHG 149
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 99.0 bits (245), Expect = 1e-20
Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 12/248 (4%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+++ V + P+ + L + RD +RIW N + + HT V + C +G+
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQ 116
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
+ ++AS D TVKVW H+ + +L H ++V+ ++ D L+ SA D+ + LWD
Sbjct: 117 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--- 173
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
++ S + + + + GT I + + ++VWD RT L +
Sbjct: 174 ------KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
H+ V L + G ++ SSD T+++ L + R + T H + + +
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 269 SGGRDRKI 276
SGG D ++
Sbjct: 288 SGGSDEQV 295
Score = 84.7 bits (208), Expect = 3e-16
Identities = 47/191 (24%), Positives = 93/191 (48%), Gaps = 12/191 (6%)
Query: 47 TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHK 106
TA D +++W+ ++ K ++ S+ H +WV +G+ ++SAS D TVK+W+
Sbjct: 120 TASDDKTVKVWATHRQK---FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSG 166
C+ + H +V + + +A+AG+D + +WDV T L + + +++++G
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL--QHYQLHSAAVNG 234
Query: 167 NKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL 226
L+ + G +++ S++ L++ D L L GH + +R G
Sbjct: 235 -------LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 227 SGSSDGTIRLW 237
SG SD + +W
Sbjct: 288 SGGSDEQVMVW 298
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/281 (19%), Positives = 113/281 (40%), Gaps = 12/281 (4%)
Query: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86
K +R+ V + +L + DS + +W + K H D V + +
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHM---KPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
G L S S D TV++W + + R H V+++ + D + +A D+ + +W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW-- 130
Query: 147 NTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL 206
A++ SLS + + + + G +IVS S +K +++WD + +
Sbjct: 131 -------ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 207 KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH 266
H V + + GT + D T+++W + R + Y++H V L + + +
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 267 VYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSAD 307
+ + D + DL + + + P + R+ +
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284
Score = 63.9 bits (154), Expect = 5e-10
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 5/128 (3%)
Query: 22 RDEVEKYNRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
R+ V Y +G V + P+ + AG D+ +++W V H+ + + H+ VN
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---LLQHYQLHSAAVN 233
Query: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDR 139
+ +G LI+ASSD+T+K+ + +G + TL H+ +A+++ E AS G D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
Query: 140 QIFLWDVN 147
Q+ +W N
Sbjct: 294 QVMVWKSN 301
Score = 63.2 bits (152), Expect = 8e-10
Identities = 42/212 (19%), Positives = 92/212 (43%), Gaps = 12/212 (5%)
Query: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175
H+D V + ++ + + +AS +D + +W + + +G+KD++ +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSR---------AYRFTGHKDAVTCVN 68
Query: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
+ G ++ SGS +K +R+W P + + HT V+++ DG ++ S D T++
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKA 295
+W+ +Q+ + + H V + + + S D+ + D + + CE
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 296 PVLKMELDRSADPPPAIWVATTKSTVNKWTLK 327
V ++ S I A +TV W ++
Sbjct: 189 FVTYVDFHPSG---TCIAAAGMDNTVKVWDVR 217
Score = 43.9 bits (102), Expect = 5e-04
Identities = 36/171 (21%), Positives = 75/171 (43%), Gaps = 8/171 (4%)
Query: 166 GNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQC 225
G++D++ + + + SGS + L VW + ++ + GH D V + + G
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 226 LSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQ-VNDAFTHV-YSGGRDRKIYCTDLR- 282
SGS D T+R+W + +R H V ++ +D + V S + K++ T +
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 283 -----NPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKG 328
+ I + C + +P ++ + S D +W +++ V+ + G
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 99.0 bits (245), Expect = 1e-20
Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 12/248 (4%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+++ V + P+ + L + RD +RIW N + + HT V + C +G+
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQ 116
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
+ ++AS D TVKVW H+ + +L H ++V+ ++ D L+ SA D+ + LWD
Sbjct: 117 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--- 173
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
++ S + + + + GT I + + ++VWD RT L +
Sbjct: 174 ------KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
H+ V L + G ++ SSD T+++ L + R + T H + + +
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 269 SGGRDRKI 276
SGG D ++
Sbjct: 288 SGGSDEQV 295
Score = 84.7 bits (208), Expect = 3e-16
Identities = 47/191 (24%), Positives = 93/191 (48%), Gaps = 12/191 (6%)
Query: 47 TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHK 106
TA D +++W+ ++ K ++ S+ H +WV +G+ ++SAS D TVK+W+
Sbjct: 120 TASDDKTVKVWATHRQK---FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSG 166
C+ + H +V + + +A+AG+D + +WDV T L + + +++++G
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL--QHYQLHSAAVNG 234
Query: 167 NKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL 226
L+ + G +++ S++ L++ D L L GH + +R G
Sbjct: 235 -------LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 227 SGSSDGTIRLW 237
SG SD + +W
Sbjct: 288 SGGSDEQVMVW 298
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/281 (19%), Positives = 113/281 (40%), Gaps = 12/281 (4%)
Query: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86
K +R+ V + +L + DS + +W + K H D V + +
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHM---KPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
G L S S D TV++W + + R H V+++ + D + +A D+ + +W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW-- 130
Query: 147 NTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL 206
A++ SLS + + + + G +IVS S +K +++WD + +
Sbjct: 131 -------ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 207 KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH 266
H V + + GT + D T+++W + R + Y++H V L + + +
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 267 VYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSAD 307
+ + D + DL + + + P + R+ +
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284
Score = 63.9 bits (154), Expect = 5e-10
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 5/128 (3%)
Query: 22 RDEVEKYNRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
R+ V Y +G V + P+ + AG D+ +++W V H+ + + H+ VN
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---LLQHYQLHSAAVN 233
Query: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDR 139
+ +G LI+ASSD+T+K+ + +G + TL H+ +A+++ E AS G D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
Query: 140 QIFLWDVN 147
Q+ +W N
Sbjct: 294 QVMVWKSN 301
Score = 63.2 bits (152), Expect = 8e-10
Identities = 42/212 (19%), Positives = 92/212 (43%), Gaps = 12/212 (5%)
Query: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175
H+D V + ++ + + +AS +D + +W + + +G+KD++ +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSR---------AYRFTGHKDAVTCVN 68
Query: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
+ G ++ SGS +K +R+W P + + HT V+++ DG ++ S D T++
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKA 295
+W+ +Q+ + + H V + + + S D+ + D + + CE
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 296 PVLKMELDRSADPPPAIWVATTKSTVNKWTLK 327
V ++ S I A +TV W ++
Sbjct: 189 FVTYVDFHPSG---TCIAAAGMDNTVKVWDVR 217
Score = 43.9 bits (102), Expect = 5e-04
Identities = 36/171 (21%), Positives = 75/171 (43%), Gaps = 8/171 (4%)
Query: 166 GNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQC 225
G++D++ + + + SGS + L VW + ++ + GH D V + + G
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 226 LSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQ-VNDAFTHV-YSGGRDRKIYCTDLR- 282
SGS D T+R+W + +R H V ++ +D + V S + K++ T +
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 283 -----NPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKG 328
+ I + C + +P ++ + S D +W +++ V+ + G
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 96.3 bits (238), Expect = 8e-20
Identities = 59/248 (23%), Positives = 109/248 (43%), Gaps = 29/248 (11%)
Query: 47 TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG---KTLISASSDTTVKVWN 103
+ +D +RIW +N+ Q +A HT V + CC+ L++ S D TVK+W
Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTV--CCSRLKESFLVTGSQDCTVKLWP 450
Query: 104 AHKGF---------------CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
K +T R H + ++A A + +L+A+ DR LW +
Sbjct: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQ 510
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
L SG++ ++ + + + ++ + S + +++W + + L +G
Sbjct: 511 CQLLGV---------FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEG 561
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
H +V + GTQ LS SDG ++LW++ C+ T H++ VW L + H
Sbjct: 562 HDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHAL 621
Query: 269 SGGRDRKI 276
+G D ++
Sbjct: 622 TGASDSRV 629
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/278 (21%), Positives = 117/278 (42%), Gaps = 17/278 (6%)
Query: 28 YNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG 87
Y+ ++ L P + + A ++++ + Q + HTD V + + G
Sbjct: 333 YSEEVLDVRFLGPEDSHVVVASNSPCLKVFEL----QTSACQILHGHTDIVLALDVFRKG 388
Query: 88 KTLISASSDTTVKVWNAHKG---FCMSTLRTHKDYVKALAYAKDKE-LVASAGLDRQIFL 143
S + D +V++W +K C++ H V + ++ KE + + D + L
Sbjct: 389 WLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKL 448
Query: 144 WDVNT--LTALTASNN-----TVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
W + L+ TA +N T+ +KD I S+A+ ++ +GS ++ ++W
Sbjct: 449 WPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD-INSVAIAPNDKLLATGSQDRTAKLWA 507
Query: 197 PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256
C L GH + + + + S+DGTI+LW+L C+ T+ HD V
Sbjct: 508 LPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
Query: 257 ALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLICEE 293
+ T + S G D + ++N + +R L E
Sbjct: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHE 605
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/168 (23%), Positives = 74/168 (44%), Gaps = 8/168 (4%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT--- 89
V + DP L T G D +R+W + +H Y + V +V T
Sbjct: 112 VATMAFDPTSTLLATGGCDGAVRVWDIVRH----YGTHHFRGSPGVVHLVAFHPDPTRLL 167
Query: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149
L S+++D ++VW+ C++ L H V +LA++ D + S+G D+ +WD+ +
Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
Query: 150 TAL-TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A T +++ ++ + L + G ++ + LRVW+
Sbjct: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
Score = 53.9 bits (128), Expect = 5e-07
Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 3/116 (2%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R G+ +Q P L TA D I++W++ + + E H V + G
Sbjct: 520 HRRGLWCVQFSPMDQVLATASADGTIKLWALQDFS---CLKTFEGHDASVLKVAFVSRGT 576
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLW 144
L+S+ SD VK+W C+ TL H+D V L ++ + + D ++ LW
Sbjct: 577 QLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/238 (22%), Positives = 94/238 (39%), Gaps = 29/238 (12%)
Query: 25 VEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC 84
+E+ ++ + A L P L TA R ++ W+ + ++ HT V +
Sbjct: 61 LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAI--HTAPVATMAFD 118
Query: 85 CNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD--KELVASAGLDRQIF 142
L + D V+VW+ + + R V +A+ D + L+ S+ D I
Sbjct: 119 PTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIR 178
Query: 143 LW---DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 199
+W D + L LTA + VT SLA + G ++S +K+ +WD ++
Sbjct: 179 VWSLQDRSCLAVLTAHYSAVT------------SLAFSADGHTMLSSGRDKICIIWDLQS 226
Query: 200 CAKLMKLKGHTDNVKALLLNRD----------GTQCLSGSSDGTIRLWSLGQQRCIAT 247
C + A+LL + G L+ GT+R+W +C+ T
Sbjct: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284
Score = 50.8 bits (120), Expect = 4e-06
Identities = 49/228 (21%), Positives = 92/228 (40%), Gaps = 24/228 (10%)
Query: 61 QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTH-KDY 119
+ K +P+ + D + C G T V + G + +L ++
Sbjct: 18 ERKIEPFYKGGKAQLDQTGQHLFCVCG---------TRVNILEVASGAVLRSLEQEDQED 68
Query: 120 VKALAYAKDKELV--ASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMN 177
+ A + D E++ AS L + W ++T L + +T +++ A +
Sbjct: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATM----------AFD 118
Query: 178 QLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL--SGSSDGTIR 235
T++ +G + +RVWD +G V + + D T+ L S ++D IR
Sbjct: 119 PTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIR 178
Query: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRN 283
+WSL + C+A H V +L + + S GRD+ DL++
Sbjct: 179 VWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
Score = 50.1 bits (118), Expect = 7e-06
Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 25/250 (10%)
Query: 7 QNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTA--GRDSIIRIWSVNQHKQ 64
+ AG + + +Y + ++E + + G QLD LF R +I+ + S
Sbjct: 3 ETAAGVGRFKTNYAVERKIEPFYKGG--KAQLDQTGQHLFCVCGTRVNILEVAS------ 54
Query: 65 DPYIASMEHHT-DWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRT-HKDYVKA 122
+ S+E + + L + + L++AS + W +G + H V
Sbjct: 55 GAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVAT 114
Query: 123 LAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT- 181
+A+ L+A+ G D + +WD+ T G+ ++ +A + T
Sbjct: 115 MAFDPTSTLLATGGCDGAVRVWDIV---------RHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 182 -IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240
++ S +T+ +RVW + + L L H V +L + DG LS D +W L
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL- 224
Query: 241 QQRCIATYRV 250
Q C AT V
Sbjct: 225 -QSCQATRTV 233
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 95.9 bits (237), Expect = 1e-19
Identities = 66/257 (25%), Positives = 123/257 (47%), Gaps = 21/257 (8%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
V + P + L +AG D +I +W+V + A+++ H+ V ++ +G L S
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNV--YGDCDNYATLKGHSGAVMELHYNTDGSMLFS 126
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQIFLWDVNTLTA 151
AS+D TV VW++ G + L+ H +V + A+ +LV + D + LWD+ A
Sbjct: 127 ASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAA 186
Query: 152 LTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTD 211
+ NT + ++ N I+SG + ++VWD R ++GH D
Sbjct: 187 IQTFQNTY----------QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
Query: 212 NVKALLLNRDGTQCLSGSSDGTIRLWSL----GQQRCIATYR--VH--DEGVWALQVNDA 263
+V L L+ +G+ LS + D T+R+W + ++RC+ ++ VH ++ + +
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
Query: 264 FTHVYSGGRDRKIYCTD 280
+ + +G DR +Y D
Sbjct: 297 GSKIAAGSADRFVYVWD 313
Score = 89.0 bits (219), Expect = 1e-17
Identities = 56/171 (32%), Positives = 88/171 (51%), Gaps = 10/171 (5%)
Query: 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIY 172
L H+ V + + +ASAG DR I LW+V + ++L G+ ++
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV--------YGDCDNYATLKGHSGAVM 113
Query: 173 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL-SGSSD 231
L N G+++ S ST+K + VWD T ++ +LKGHT V + R G Q + +GS D
Sbjct: 114 ELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDD 173
Query: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
GT++LW + ++ I T++ + V A+ ND + SGG D I DLR
Sbjct: 174 GTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223
Score = 80.9 bits (198), Expect = 4e-15
Identities = 58/208 (27%), Positives = 94/208 (45%), Gaps = 18/208 (8%)
Query: 82 VLCC----NGKTLISASSDTTVKVWNAHKGFC--MSTLRTHKDYVKALAYAKDKELVASA 135
V CC NG TL SA D + +WN + G C +TL+ H V L Y D ++ SA
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 136 GLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRV 194
D+ + +WD S L G+ + S + G ++ +GS + +++
Sbjct: 128 STDKTVAVWD---------SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
Query: 195 WDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEG 254
WD R A + + +T V A+ N Q +SG D I++W L Q + T R H +
Sbjct: 179 WDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS 237
Query: 255 VWALQVNDAFTHVYSGGRDRKIYCTDLR 282
V L ++ +++ S D + D+R
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 79.7 bits (195), Expect = 8e-15
Identities = 56/249 (22%), Positives = 114/249 (45%), Gaps = 26/249 (10%)
Query: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLI-SASSDTTVKVWN 103
LF+A D + +W ++ + ++ HT +VN G L+ + S D TVK+W+
Sbjct: 124 LFSASTDKTVAVWDSETGER---VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 104 AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSS 163
K + T + V A+ + + + S G+D I +WD+ T +
Sbjct: 181 IRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLR---------QNKLTYT 230
Query: 164 LSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT------CAKLMKLKGHTDNVKALL 217
+ G+ DS+ L+++ G+ ++S + + +RVWD R C K+ + G+ N + L
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ--GNVHNFEKNL 288
Query: 218 L----NRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRD 273
L + DG++ +GS+D + +W +R + H + + + + S D
Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Query: 274 RKIYCTDLR 282
+++Y +++
Sbjct: 349 KRLYMGEIQ 357
Score = 57.0 bits (136), Expect = 6e-08
Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 20/172 (11%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
N V A+ + +++ + G D+ I++W + Q+K +M H D V + L G
Sbjct: 192 NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK---LTYTMRGHADSVTGLSLSSEGS 248
Query: 89 TLISASSDTTVKVWN----AHKGFCMSTLRTH-KDYVKAL---AYAKDKELVASAGLDRQ 140
L+S + D TV+VW+ A K C+ + + ++ K L +++ D +A+ DR
Sbjct: 249 YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF 308
Query: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVL 192
+++WD + L L G+ SI +A + II+S S++K L
Sbjct: 309 VYVWDTTSRRIL---------YKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 37.4 bits (85), Expect = 0.046
Identities = 26/139 (18%), Positives = 62/139 (44%), Gaps = 10/139 (7%)
Query: 13 RKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHK-QDPYIASM 71
R+ +++Y +R + V L L + L + D+ +R+W V ++ +
Sbjct: 223 RQNKLTYTMRGHADS-----VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 72 EHHTDWVNDIVLCCN----GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK 127
+ + +L C+ G + + S+D V VW+ + L H + +A+
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Query: 128 DKELVASAGLDRQIFLWDV 146
D+ ++ SA D+++++ ++
Sbjct: 338 DEPIIISASSDKRLYMGEI 356
Score = 32.3 bits (72), Expect = 1.5
Identities = 46/215 (21%), Positives = 77/215 (35%), Gaps = 33/215 (15%)
Query: 201 AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL-GQQRCIATYRVHDEGVWALQ 259
A +M L GH V + +G+ S D I LW++ G AT + H V L
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
Query: 260 VNDAFTHVYSGGRDRKIYCTD---------LRNPDIRVLICEEKAPVLKMELDRSADPPP 310
N + ++S D+ + D L+ V C ++ S D
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
Query: 311 AIWVATTKSTVNKW---------TLKGIHNFRASGDYDNDC------TNPITPLCTQPDQ 355
+W K+ + + T + SG DND N +T
Sbjct: 177 KLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT-------Y 229
Query: 356 VIKGGA-SIIQCHILNDKRHILTKDTNNNVAYWDV 389
++G A S+ + ++ ++L+ +N V WDV
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 95.5 bits (236), Expect = 1e-19
Identities = 70/255 (27%), Positives = 112/255 (43%), Gaps = 14/255 (5%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R G+N L L P RL T D R+WS + A ++ H +V L +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQ---CCALLQGHESYVTFCQL--EDE 68
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
+ S+D T++ W+ G C+ R H V + A ++ + S+ DR +W V+
Sbjct: 69 AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDK 126
Query: 149 ---LTALTASNNTVTTSSLSGNKDSIYSLAMNQL--GTIIVSGSTEKVLRVWDPRTCAKL 203
N V T + S D + + G ++V+GST+ +VW +
Sbjct: 127 GQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCH 186
Query: 204 MKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263
L+GHT V L+L+ G +GS+D TIR W + + +R H V L++ +
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
Query: 264 FTHVYSGGRDRKIYC 278
VYSG DR + C
Sbjct: 247 L--VYSGSADRTVKC 259
Score = 72.4 bits (176), Expect = 1e-12
Identities = 83/348 (23%), Positives = 132/348 (37%), Gaps = 51/348 (14%)
Query: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
H +N + L +G+ L++ S D T ++W+ G C + L+ H+ YV +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 134 SAGLDRQIFLWDVNTLTALTA--SNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKV 191
SA D I WDV T L + ++ L N NQL S S ++
Sbjct: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN---------NQL----FSSSYDRT 118
Query: 192 LRVWDPRTCAKLMKLKGHTDNVKALLLNRD----GTQC----------LSGSSDGTIRLW 237
RVW + +GH + V L + T C ++GS+DGT ++W
Sbjct: 119 ARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
Query: 238 SLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPV 297
+ C T R H V L ++ ++G D I D+ + + + E + V
Sbjct: 179 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV 238
Query: 298 LKMEL------DRSADPPPAIWVATTKSTVNKWTLKGIH----------NFRASGDYDND 341
+ +EL SAD W+A T V +T + F SGD
Sbjct: 239 ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGD---A 295
Query: 342 CTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDV 389
C + +V +G II C I + + T + + WDV
Sbjct: 296 CARAFDAQSGELRRVFRGHTFIINC-IQVHGQVLYTASHDGALRLWDV 342
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 26/272 (9%)
Query: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
GR +Q R + N GV LQ D ++ + RD+ I+IW + +
Sbjct: 226 GRHNLQ-----RIQCRSENSKGVYCLQYDD--EKIISGLRDNSIKIWDKTSLE---CLKV 275
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
+ HT V + L + + +++ SSD+TV+VW+ + G ++TL H + V L ++
Sbjct: 276 LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-- 331
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
L+ + DR I +WD+ + T +T L G++ ++ + + IVS S ++
Sbjct: 332 LMVTCSKDRSIAVWDMASATDITLRR------VLVGHRAAVNVVDFDD--KYIVSASGDR 383
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
++VW TC + L GH + A L RD +SGSSD TIRLW + C+
Sbjct: 384 TIKVWSTSTCEFVRTLNGHKRGI-ACLQYRD-RLVVSGSSDNTIRLWDIECGACLRVLEG 441
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
H+E V ++ ++ + SG D KI DL+
Sbjct: 442 HEELVRCIRFDN--KRIVSGAYDGKIKVWDLQ 471
Score = 60.1 bits (144), Expect = 7e-09
Identities = 37/168 (22%), Positives = 80/168 (47%), Gaps = 11/168 (6%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R VN + D + +A D I++WS + + ++ ++ H + L +
Sbjct: 362 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCE---FVRTLNGHKRGI--ACLQYRDR 414
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
++S SSD T+++W+ G C+ L H++ V+ + + D + + S D +I +WD+
Sbjct: 415 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA 472
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A +T+ +L + ++ L ++ I+S S + + +WD
Sbjct: 473 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 518
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 26/272 (9%)
Query: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
GR +Q R + N GV LQ D ++ + RD+ I+IW + +
Sbjct: 192 GRHNLQ-----RIQCRSENSKGVYCLQYDD--EKIISGLRDNSIKIWDKTSLE---CLKV 241
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
+ HT V + L + + +++ SSD+TV+VW+ + G ++TL H + V L ++
Sbjct: 242 LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-- 297
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
L+ + DR I +WD+ + T +T L G++ ++ + + IVS S ++
Sbjct: 298 LMVTCSKDRSIAVWDMASATDITLRR------VLVGHRAAVNVVDFDD--KYIVSASGDR 349
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
++VW TC + L GH + A L RD +SGSSD TIRLW + C+
Sbjct: 350 TIKVWSTSTCEFVRTLNGHKRGI-ACLQYRD-RLVVSGSSDNTIRLWDIECGACLRVLEG 407
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
H+E V ++ ++ + SG D KI DL+
Sbjct: 408 HEELVRCIRFDN--KRIVSGAYDGKIKVWDLQ 437
Score = 60.1 bits (144), Expect = 7e-09
Identities = 37/168 (22%), Positives = 80/168 (47%), Gaps = 11/168 (6%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R VN + D + +A D I++WS + + ++ ++ H + L +
Sbjct: 328 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCE---FVRTLNGHKRGI--ACLQYRDR 380
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
++S SSD T+++W+ G C+ L H++ V+ + + D + + S D +I +WD+
Sbjct: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA 438
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A +T+ +L + ++ L ++ I+S S + + +WD
Sbjct: 439 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 26/272 (9%)
Query: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
GR +Q R + N GV LQ D ++ + RD+ I+IW + +
Sbjct: 213 GRHNLQ-----RIQCRSENSKGVYCLQYDD--EKIISGLRDNSIKIWDKTSLE---CLKV 262
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
+ HT V + L + + +++ SSD+TV+VW+ + G ++TL H + V L ++
Sbjct: 263 LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-- 318
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
L+ + DR I +WD+ + T +T L G++ ++ + + IVS S ++
Sbjct: 319 LMVTCSKDRSIAVWDMASATDITLRR------VLVGHRAAVNVVDFDD--KYIVSASGDR 370
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
++VW TC + L GH + A L RD +SGSSD TIRLW + C+
Sbjct: 371 TIKVWSTSTCEFVRTLNGHKRGI-ACLQYRD-RLVVSGSSDNTIRLWDIECGACLRVLEG 428
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
H+E V ++ ++ + SG D KI DL+
Sbjct: 429 HEELVRCIRFDN--KRIVSGAYDGKIKVWDLQ 458
Score = 60.1 bits (144), Expect = 7e-09
Identities = 37/168 (22%), Positives = 80/168 (47%), Gaps = 11/168 (6%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R VN + D + +A D I++WS + + ++ ++ H + L +
Sbjct: 349 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCE---FVRTLNGHKRGI--ACLQYRDR 401
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
++S SSD T+++W+ G C+ L H++ V+ + + D + + S D +I +WD+
Sbjct: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA 459
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A +T+ +L + ++ L ++ I+S S + + +WD
Sbjct: 460 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 505
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 93.2 bits (230), Expect = 7e-19
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
NR+ + D+ +++WS K + ++ HT V + N +IS S+D T+KVW
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGK---CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVW 328
Query: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
NA G C+ TL H V+ + + + V S D + +WD+ T L
Sbjct: 329 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHV-------- 378
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
L G+ ++ + + G +VSG+ + +++VWDP T L L+GHT+ V +L DG
Sbjct: 379 -LMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 433
Query: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
+SGS D +IR+W + CI T H +++ D + SG D + D++
Sbjct: 434 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 491
Score = 87.0 bits (214), Expect = 5e-17
Identities = 81/319 (25%), Positives = 135/319 (42%), Gaps = 43/319 (13%)
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
++ H D V + C G ++S S D T+KVW+A G C+ TL H V + + +D
Sbjct: 258 LKGHDDHVITCLQFC-GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS-SQMRD-N 314
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
++ S DR + +W+ T + +L G+ ++ + +++ +VSGS +
Sbjct: 315 IIISGSTDRTLKVWNAETGECI---------HTLYGHTSTVRCMHLHE--KRVVSGSRDA 363
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
LRVWD T L L GH V+ + DG + +SG+ D +++W + C+ T +
Sbjct: 364 TLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 421
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPP 310
H V++LQ + HV SG D I D+ + + ++ MEL +
Sbjct: 422 HTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----- 474
Query: 311 AIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILN 370
+ STV W +K T C Q Q S + C N
Sbjct: 475 ILVSGNADSTVKIWDIK-------------------TGQCLQTLQGPNKHQSAVTCLQFN 515
Query: 371 DKRHILTKDTNNNVAYWDV 389
K ++T + V WD+
Sbjct: 516 -KNFVITSSDDGTVKLWDL 533
Score = 29.6 bits (65), Expect = 9.5
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
N L + DS ++IW + + + H V L N +I++S D TVK+W
Sbjct: 474 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT--CLQFNKNFVITSSDDGTVKLW 531
Query: 103 NAHKGFCMSTLRT 115
+ G + L T
Sbjct: 532 DLKTGEFIRNLVT 544
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 93.2 bits (230), Expect = 7e-19
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
NR+ + D+ +++WS K + ++ HT V + N +IS S+D T+KVW
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGK---CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVW 446
Query: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
NA G C+ TL H V+ + + + V S D + +WD+ T L
Sbjct: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHV-------- 496
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
L G+ ++ + + G +VSG+ + +++VWDP T L L+GHT+ V +L DG
Sbjct: 497 -LMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 551
Query: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
+SGS D +IR+W + CI T H +++ D + SG D + D++
Sbjct: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 609
Score = 87.0 bits (214), Expect = 5e-17
Identities = 81/319 (25%), Positives = 135/319 (42%), Gaps = 43/319 (13%)
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
++ H D V + C G ++S S D T+KVW+A G C+ TL H V + + +D
Sbjct: 376 LKGHDDHVITCLQFC-GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS-SQMRD-N 432
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
++ S DR + +W+ T + +L G+ ++ + +++ +VSGS +
Sbjct: 433 IIISGSTDRTLKVWNAETGECI---------HTLYGHTSTVRCMHLHE--KRVVSGSRDA 481
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
LRVWD T L L GH V+ + DG + +SG+ D +++W + C+ T +
Sbjct: 482 TLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPP 310
H V++LQ + HV SG D I D+ + + ++ MEL +
Sbjct: 540 HTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----- 592
Query: 311 AIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILN 370
+ STV W +K T C Q Q S + C N
Sbjct: 593 ILVSGNADSTVKIWDIK-------------------TGQCLQTLQGPNKHQSAVTCLQFN 633
Query: 371 DKRHILTKDTNNNVAYWDV 389
K ++T + V WD+
Sbjct: 634 -KNFVITSSDDGTVKLWDL 651
Score = 29.6 bits (65), Expect = 9.5
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
N L + DS ++IW + + + H V L N +I++S D TVK+W
Sbjct: 592 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT--CLQFNKNFVITSSDDGTVKLW 649
Query: 103 NAHKGFCMSTLRT 115
+ G + L T
Sbjct: 650 DLKTGEFIRNLVT 662
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 93.2 bits (230), Expect = 7e-19
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
NR+ + D+ +++WS K + ++ HT V + N +IS S+D T+KVW
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGK---CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVW 366
Query: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
NA G C+ TL H V+ + + + V S D + +WD+ T L
Sbjct: 367 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHV-------- 416
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
L G+ ++ + + G +VSG+ + +++VWDP T L L+GHT+ V +L DG
Sbjct: 417 -LMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 471
Query: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
+SGS D +IR+W + CI T H +++ D + SG D + D++
Sbjct: 472 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 529
Score = 87.0 bits (214), Expect = 5e-17
Identities = 81/319 (25%), Positives = 135/319 (42%), Gaps = 43/319 (13%)
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
++ H D V + C G ++S S D T+KVW+A G C+ TL H V + + +D
Sbjct: 296 LKGHDDHVITCLQFC-GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS-SQMRD-N 352
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
++ S DR + +W+ T + +L G+ ++ + +++ +VSGS +
Sbjct: 353 IIISGSTDRTLKVWNAETGECI---------HTLYGHTSTVRCMHLHE--KRVVSGSRDA 401
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
LRVWD T L L GH V+ + DG + +SG+ D +++W + C+ T +
Sbjct: 402 TLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 459
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPP 310
H V++LQ + HV SG D I D+ + + ++ MEL +
Sbjct: 460 HTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----- 512
Query: 311 AIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILN 370
+ STV W +K T C Q Q S + C N
Sbjct: 513 ILVSGNADSTVKIWDIK-------------------TGQCLQTLQGPNKHQSAVTCLQFN 553
Query: 371 DKRHILTKDTNNNVAYWDV 389
K ++T + V WD+
Sbjct: 554 -KNFVITSSDDGTVKLWDL 571
Score = 29.6 bits (65), Expect = 9.5
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
N L + DS ++IW + + + H V L N +I++S D TVK+W
Sbjct: 512 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT--CLQFNKNFVITSSDDGTVKLW 569
Query: 103 NAHKGFCMSTLRT 115
+ G + L T
Sbjct: 570 DLKTGEFIRNLVT 582
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 92.8 bits (229), Expect = 9e-19
Identities = 70/260 (26%), Positives = 111/260 (42%), Gaps = 29/260 (11%)
Query: 13 RKVQVSYVIRDEVEKYNRNGVNALQL------------DPALNR----LFTAGRDSIIRI 56
R QV +I+ EK +N + L + ALN+ T D ++
Sbjct: 59 RTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKL 118
Query: 57 WSVNQHKQDPYIASMEHHTDWVNDIVLCCN-GKTLISASSDTTVKVWNAHKGFCMSTLRT 115
W ++ + ++E H + V I G + + S D T K+W+ G C T R
Sbjct: 119 WDTASGEE---LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG 175
Query: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175
H + L++ LVA+ +D LWD+ N +L G+ I SL+
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ---------NGEEVYTLRGHSAEIISLS 226
Query: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
N G I++GS + + VWD T K+ L GH + + N D + L+GS D T +
Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCK 286
Query: 236 LWSLGQQRCIATYRVHDEGV 255
LW +C+AT HD+ +
Sbjct: 287 LWDATNGKCVATLTGHDDEI 306
Score = 92.4 bits (228), Expect = 1e-18
Identities = 54/238 (22%), Positives = 107/238 (44%), Gaps = 12/238 (5%)
Query: 36 LQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASS 95
L +P + T D+ ++W + ++ + ++ H+ + + +G +I+ S
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWDIQNGEE---VYTLRGHSAEIISLSFNTSGDRIITGSF 239
Query: 96 DTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAS 155
D TV VW+A G ++ L H + + ++ D L+ + +D+ LWD +
Sbjct: 240 DHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD---------A 290
Query: 156 NNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKA 215
N ++L+G+ D I + G +I + S + R++ T + KL+GH +
Sbjct: 291 TNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK 350
Query: 216 LLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRD 273
+ N G L+GSSD T R+W +C+ H + +++ N V +G +D
Sbjct: 351 ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/221 (24%), Positives = 104/221 (47%), Gaps = 16/221 (7%)
Query: 21 IRDEVEKYNRNGVNA----LQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTD 76
I++ E Y G +A L + + +R+ T D + +W + ++ + + H
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK---VNILIGHCA 262
Query: 77 WVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAG 136
++ + +++ S D T K+W+A G C++TL H D + + +L+A+A
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 137 LDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
D ++ T + + L G++ I ++ N G +++GS++K R+WD
Sbjct: 323 ADGTARIFSAATRKCI---------AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 197 PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
+T L L+GHTD + + N G ++GS D T R+W
Sbjct: 374 AQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 87.0 bits (214), Expect = 5e-17
Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 13/247 (5%)
Query: 29 NRNGVNALQLD-PALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG 87
+RN V A+ + P +++ T D ++WSV K + HT + +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK---CYHTFRGHTAEIVCLSFNPQS 189
Query: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147
+ + S DTT K+W+ G + TLR H + +L++ + + + D + +WD +
Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249
Query: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207
T + L G+ I S + N ++I++GS +K ++WD + L
Sbjct: 250 TGRKVNI---------LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHV 267
GH D + + G + S+DGT R++S ++CIA H+ + + N H+
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
Query: 268 YSGGRDR 274
+G D+
Sbjct: 361 LTGSSDK 367
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/226 (25%), Positives = 90/226 (39%), Gaps = 18/226 (7%)
Query: 105 HKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSL 164
H + L+ H + +A K + DR LWD TAS + T L
Sbjct: 80 HTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD-------TASGEELNT--L 130
Query: 165 SGNKDSIYSLAMNQ-LGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGT 223
G+++ +Y++A N G I +GS +K ++W T +GHT + L N T
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
Query: 224 QCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL-- 281
+GS D T +LW + + T R H + +L N + + +G D + D
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 282 -RNPDIRVLICEEKAPV-----LKMELDRSADPPPAIWVATTKSTV 321
R +I + C E + + L S D +W AT V
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 92.0 bits (227), Expect = 2e-18
Identities = 57/205 (27%), Positives = 95/205 (46%), Gaps = 12/205 (5%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
V+ + + P + L + G D R+W V + + + HTDW++D +G L +
Sbjct: 355 VSCVSMQPHKDILVSCGED---RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLAT 411
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAL 152
+S DTTVK+W+ KG C+ T H V + + VAS+ LD+ +WDVN+
Sbjct: 412 SSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC- 470
Query: 153 TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN 212
+L G+ DS+ S+ +++ S +K L +WD RT L GH +
Sbjct: 471 --------RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHS 522
Query: 213 VKALLLNRDGTQCLSGSSDGTIRLW 237
+ + + G S + G +LW
Sbjct: 523 INDAIFDPRGHMIASCDACGVTKLW 547
Score = 77.4 bits (189), Expect = 4e-14
Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 13/196 (6%)
Query: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
N + ++ D +IW VN + ++ HTD VN I TL+++S+D T+ +W
Sbjct: 449 NFVASSSLDKTSKIWDVNSERCR---CTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
Query: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
+A G C +L H + + ++AS LWD L + ++
Sbjct: 506 DARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIV----SIDIG 561
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
GN+ + + G ++ S V+ + D ++ ++ KL GH + ++ + DG
Sbjct: 562 PSPGNE-----VNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHDG 615
Query: 223 TQCLSGSSDGTIRLWS 238
SG SDGT+R WS
Sbjct: 616 EILFSGGSDGTVRTWS 631
Score = 52.4 bits (124), Expect = 1e-06
Identities = 38/144 (26%), Positives = 60/144 (41%), Gaps = 8/144 (5%)
Query: 182 IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQ 241
I+VS +++ +V C L+ GHTD + + G + + S D T++LW L +
Sbjct: 366 ILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCK 425
Query: 242 QRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKME 301
CI T+ H VW+ + V S D+ D+ + R + V +E
Sbjct: 426 GDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIE 485
Query: 302 --------LDRSADPPPAIWVATT 317
L SAD +IW A T
Sbjct: 486 FFPFSNTLLTSSADKTLSIWDART 509
Score = 46.2 bits (108), Expect = 1e-04
Identities = 40/180 (22%), Positives = 75/180 (41%), Gaps = 14/180 (7%)
Query: 114 RTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYS 173
R H+ V ++ K+++ S G DR LW V L N + T G+ D +
Sbjct: 349 RLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKC----NVLLTGF--GHTDWLSD 399
Query: 174 LAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 233
+ G + + S + +++WD ++ +GH+ V + + G S S D T
Sbjct: 400 CCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKT 459
Query: 234 IRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEE 293
++W + +RC T H + V +++ + + D+ + D R ICE+
Sbjct: 460 SKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG-----ICEQ 514
Score = 39.3 bits (90), Expect = 0.012
Identities = 31/165 (18%), Positives = 66/165 (40%), Gaps = 13/165 (7%)
Query: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90
+ VN+++ P N L T+ D + IW + S+ H +ND + G +
Sbjct: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE---QSLYGHMHSINDAIFDPRGHMI 535
Query: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150
S + K+W+ K + ++ + + ++A A + I L D+
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL---- 591
Query: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW 195
+ L G+++ +++ + G I+ SG ++ +R W
Sbjct: 592 ------KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/271 (29%), Positives = 132/271 (48%), Gaps = 26/271 (9%)
Query: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
GR +Q + R E K GV LQ D ++ + RD+ I+IW N + +
Sbjct: 253 GRHSLQRIHC-RSETSK----GVYCLQYDD--QKIVSGLRDNTIKIWDKNTLECKRILTG 305
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
HT V + L + + +I+ SSD+TV+VW+ + G ++TL H + V L + +
Sbjct: 306 ---HTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNG 358
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
++ + DR I +WD+ + T +T L G++ ++ + + IVS S ++
Sbjct: 359 MMVTCSKDRSIAVWDMASPTDITLRR------VLVGHRAAVNVVDFDD--KYIVSASGDR 410
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
++VW+ TC + L GH + A L RD +SGSSD TIRLW + C+
Sbjct: 411 TIKVWNTSTCEFVRTLNGHKRGI-ACLQYRD-RLVVSGSSDNTIRLWDIECGACLRVLEG 468
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
H+E V ++ ++ + SG D KI DL
Sbjct: 469 HEELVRCIRFDN--KRIVSGAYDGKIKVWDL 497
Score = 57.8 bits (138), Expect = 3e-08
Identities = 37/168 (22%), Positives = 79/168 (47%), Gaps = 11/168 (6%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R VN + D + +A D I++W+ + + ++ ++ H + L +
Sbjct: 389 HRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCE---FVRTLNGHKRGI--ACLQYRDR 441
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
++S SSD T+++W+ G C+ L H++ V+ + + D + + S D +I +WD+
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA 499
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A T+ +L + ++ L ++ IVS S + + +WD
Sbjct: 500 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 545
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/271 (29%), Positives = 132/271 (48%), Gaps = 26/271 (9%)
Query: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
GR +Q + R E K GV LQ D ++ + RD+ I+IW N + +
Sbjct: 289 GRHSLQRIHC-RSETSK----GVYCLQYDD--QKIVSGLRDNTIKIWDKNTLECKRILTG 341
Query: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
HT V + L + + +I+ SSD+TV+VW+ + G ++TL H + V L + +
Sbjct: 342 ---HTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNG 394
Query: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
++ + DR I +WD+ + T +T L G++ ++ + + IVS S ++
Sbjct: 395 MMVTCSKDRSIAVWDMASPTDITLRR------VLVGHRAAVNVVDFDD--KYIVSASGDR 446
Query: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
++VW+ TC + L GH + A L RD +SGSSD TIRLW + C+
Sbjct: 447 TIKVWNTSTCEFVRTLNGHKRGI-ACLQYRD-RLVVSGSSDNTIRLWDIECGACLRVLEG 504
Query: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
H+E V ++ ++ + SG D KI DL
Sbjct: 505 HEELVRCIRFDN--KRIVSGAYDGKIKVWDL 533
Score = 57.8 bits (138), Expect = 3e-08
Identities = 37/168 (22%), Positives = 79/168 (47%), Gaps = 11/168 (6%)
Query: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
+R VN + D + +A D I++W+ + + ++ ++ H + L +
Sbjct: 425 HRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCE---FVRTLNGHKRGI--ACLQYRDR 477
Query: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
++S SSD T+++W+ G C+ L H++ V+ + + D + + S D +I +WD+
Sbjct: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA 535
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
A T+ +L + ++ L ++ IVS S + + +WD
Sbjct: 536 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 581
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 87.0 bits (214), Expect = 5e-17
Identities = 69/273 (25%), Positives = 117/273 (42%), Gaps = 38/273 (13%)
Query: 36 LQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASS 95
L +P + ++ +D +RIW + + + HT V + +G L SAS
Sbjct: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTG---HTQSVTCLRWGGDG-LLYSASQ 265
Query: 96 DTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD--------------------------- 128
D T+KVW AH G TL+ H +V +A + D
Sbjct: 266 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL 325
Query: 129 KE-------LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT 181
KE LV G +R + D TL + + + + ++G++ I + +
Sbjct: 326 KERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR 385
Query: 182 IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQ 241
I+ S S +K +++WD RT L L+GH V + + D +SGSSD T+++W +
Sbjct: 386 IVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA 445
Query: 242 QRCIATYRVHDEGVWALQVNDAFTHVYSGGRDR 274
Q+ H + V+A+ + V SGG+D+
Sbjct: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
Score = 81.6 bits (200), Expect = 2e-15
Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 10/149 (6%)
Query: 90 LISASSDTTVKVWN-AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
L+S S D T+ +W+ A ++ + H+ + + ++ D +VASA D+ I LWD T
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
L +SL G+ ++Y +A + ++VSGS++ L+VWD + M L G
Sbjct: 404 GKYL---------ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
Query: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
H D V A+ + DG + SG D +R+W
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/174 (28%), Positives = 79/174 (45%), Gaps = 14/174 (8%)
Query: 69 ASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD 128
+S+E H++ V + GK L S S DTTV+ W+ T + H+ +V +++++ D
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Query: 129 KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-----II 183
+AS + QI LWD +T +L+G+ I L+ L +
Sbjct: 168 GRKLASGCKNGQILLWDPST--------GKQVGRTLAGHSKWITGLSWEPLHANPECRYV 219
Query: 184 VSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
S S + +R+WD L GHT +V L DG S S D TI++W
Sbjct: 220 ASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW 272
Score = 57.8 bits (138), Expect = 3e-08
Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 3/112 (2%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
+N + P + +A D I++W K Y+AS+ H V I + + L+S
Sbjct: 375 INQVLFSPDSRIVASASFDKSIKLWDGRTGK---YLASLRGHVAAVYQIAWSADSRLLVS 431
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLW 144
SSD+T+KVW+ L H D V A+ ++ D + VAS G D+ + +W
Sbjct: 432 GSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 56.6 bits (135), Expect = 7e-08
Identities = 55/210 (26%), Positives = 90/210 (42%), Gaps = 18/210 (8%)
Query: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAG--LDRQI--- 141
G L+ + D V + + L +D + + D E+V+S G L+ Q
Sbjct: 25 GGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQAVET 84
Query: 142 -----FLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
++ + + A T TSSL G+ +++ S+A + G + SGS + +R WD
Sbjct: 85 EKVLDIIYQPQAIFRVRAV--TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Query: 197 PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW--SLGQQ--RCIATYRVHD 252
T KGH V ++ + DG + SG +G I LW S G+Q R +A +
Sbjct: 143 LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202
Query: 253 EGV-W-ALQVNDAFTHVYSGGRDRKIYCTD 280
G+ W L N +V S +D + D
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWD 232
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 86.3 bits (212), Expect = 9e-17
Identities = 58/224 (25%), Positives = 104/224 (46%), Gaps = 12/224 (5%)
Query: 74 HTDWVNDIVLC-CNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELV 132
H V+ +VL +G+ L + D V +W+ +K C+ +L H V+++ +EL+
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 133 ASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVL 192
+ I +WD+ L +L G+K +I SL + G + SGS + +
Sbjct: 79 VAGSQSGSIRVWDLEAAKILR---------TLMGHKANICSLDFHPYGEFVASGSQDTNI 129
Query: 193 RVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHD 252
++WD R + + +GH+ V+ L + DG S + D T++LW L + ++ + H
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 253 EGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAP 296
V ++ + + SG DR I DL +V+ C E P
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEK--FQVVSCIEGEP 231
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/244 (25%), Positives = 107/244 (43%), Gaps = 13/244 (5%)
Query: 31 NGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89
+ V++L L A RL T G D + +WS+N+ I S+ HT V + L +
Sbjct: 21 SNVSSLVLGKASGRLLATGGDDCRVNLWSINKPN---CIMSLTGHTSPVESVRLNTPEEL 77
Query: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149
+++ S +++VW+ + TL HK + +L + E VAS D I LWD+
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209
+ G+ ++ L + G + S + + +++WD + + GH
Sbjct: 138 GCV---------FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGH 188
Query: 210 TDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYS 269
T V + + + SGSSD TIR W L + + ++ V ++ N +YS
Sbjct: 189 TGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS 248
Query: 270 GGRD 273
G +D
Sbjct: 249 GCQD 252
Score = 44.7 bits (104), Expect = 3e-04
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 1/105 (0%)
Query: 198 RTCAKLMKLKGHTDNVKALLLNR-DGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256
+T KL ++ H NV +L+L + G +G D + LWS+ + CI + H V
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
Query: 257 ALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKME 301
++++N + +G + I DL I + KA + ++
Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 86.3 bits (212), Expect = 9e-17
Identities = 58/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 45 LFTAGRDSI-IRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
LF +G D I++W+ +K + ++ H D++ ++SAS D T++VWN
Sbjct: 65 LFVSGGDDYKIKVWN---YKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
Query: 104 AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL-------------- 149
C+ L H YV + ++LV SA LD+ + +WD++ L
Sbjct: 122 WQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Query: 150 -----TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW--DPRTCAK 202
L + + V L G+ + A + +IVSG+ ++ +++W + +
Sbjct: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWE 241
Query: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262
+ +GH +NV + + LS S D +IR+W + ++ + T+R + W L +
Sbjct: 242 VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHP 301
Query: 263 AFTHVYSGGRD 273
++++ G D
Sbjct: 302 NL-NLFAAGHD 311
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/172 (20%), Positives = 69/172 (40%), Gaps = 9/172 (5%)
Query: 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKD 169
++ T VK L++ + + ++ + I LWD T + +
Sbjct: 2 LTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLI---------DKFDEHDG 52
Query: 170 SIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGS 229
+ + ++ + VSG + ++VW+ + L L GH D ++ + + LS S
Sbjct: 53 PVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS 112
Query: 230 SDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
D TIR+W+ + C+ H+ V Q + V S D+ + D+
Sbjct: 113 DDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
Score = 38.5 bits (88), Expect = 0.021
Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 2/115 (1%)
Query: 20 VIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
V++ +E ++R GVN P + + + D ++IW +N+ K H+ + V+
Sbjct: 196 VVKHVLEGHDR-GVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN-VS 253
Query: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134
V + ++S S D +++VW+ K + T R D LA + L A+
Sbjct: 254 CAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
Score = 38.1 bits (87), Expect = 0.027
Identities = 31/147 (21%), Positives = 57/147 (38%), Gaps = 27/147 (18%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQ------------------------DPYI 68
V Q P + + +A D +R+W ++ ++ D +
Sbjct: 138 VMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197
Query: 69 AS-MEHHTDWVNDIVLCCNGKTLISASSDTTVKVW--NAHKGFCMSTLRTHKDYVKALAY 125
+E H VN ++S + D VK+W N K + + T R H + V +
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257
Query: 126 AKDKELVASAGLDRQIFLWDVNTLTAL 152
+EL+ S D+ I +WD++ T +
Sbjct: 258 HPRQELILSNSEDKSIRVWDMSKRTGV 284
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 86.3 bits (212), Expect = 9e-17
Identities = 58/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 45 LFTAGRDSI-IRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
LF +G D I++W+ +K + ++ H D++ ++SAS D T++VWN
Sbjct: 65 LFVSGGDDYKIKVWN---YKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
Query: 104 AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL-------------- 149
C+ L H YV + ++LV SA LD+ + +WD++ L
Sbjct: 122 WQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Query: 150 -----TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW--DPRTCAK 202
L + + V L G+ + A + +IVSG+ ++ +++W + +
Sbjct: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWE 241
Query: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262
+ +GH +NV + + LS S D +IR+W + ++ + T+R + W L +
Sbjct: 242 VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHP 301
Query: 263 AFTHVYSGGRD 273
++++ G D
Sbjct: 302 NL-NLFAAGHD 311
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/172 (20%), Positives = 69/172 (40%), Gaps = 9/172 (5%)
Query: 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKD 169
++ T VK L++ + + ++ + I LWD T + +
Sbjct: 2 LTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLI---------DKFDEHDG 52
Query: 170 SIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGS 229
+ + ++ + VSG + ++VW+ + L L GH D ++ + + LS S
Sbjct: 53 PVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS 112
Query: 230 SDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
D TIR+W+ + C+ H+ V Q + V S D+ + D+
Sbjct: 113 DDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
Score = 38.5 bits (88), Expect = 0.021
Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 2/115 (1%)
Query: 20 VIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
V++ +E ++R GVN P + + + D ++IW +N+ K H+ + V+
Sbjct: 196 VVKHVLEGHDR-GVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN-VS 253
Query: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134
V + ++S S D +++VW+ K + T R D LA + L A+
Sbjct: 254 CAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
Score = 38.1 bits (87), Expect = 0.027
Identities = 31/147 (21%), Positives = 57/147 (38%), Gaps = 27/147 (18%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQ------------------------DPYI 68
V Q P + + +A D +R+W ++ ++ D +
Sbjct: 138 VMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197
Query: 69 AS-MEHHTDWVNDIVLCCNGKTLISASSDTTVKVW--NAHKGFCMSTLRTHKDYVKALAY 125
+E H VN ++S + D VK+W N K + + T R H + V +
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257
Query: 126 AKDKELVASAGLDRQIFLWDVNTLTAL 152
+EL+ S D+ I +WD++ T +
Sbjct: 258 HPRQELILSNSEDKSIRVWDMSKRTGV 284
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 85.5 bits (210), Expect = 1e-16
Identities = 58/253 (22%), Positives = 106/253 (41%), Gaps = 40/253 (15%)
Query: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
VN+ P L T D + W + + + HT V +G S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWET---RSGQLLWRLGGHTGPVKFCRFSPDGHLFAS 80
Query: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---L 149
AS D TV++W+ + C+ L+ H+ V+ ++++ D +AS G D+++ LWDV + L
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 150 TALTASNNTVTTS---------------------------------SLSGNKDSIYSLAM 176
L +++ +S +L G+ +I L
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
Query: 177 NQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRL 236
+ G ++ SGS +K + +W P T + L++LKGH VK++ + D S +++
Sbjct: 201 SASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 237 WSLGQQRCIATYR 249
W +C+ T +
Sbjct: 260 WDCNTGKCLETLK 272
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/166 (26%), Positives = 73/166 (43%), Gaps = 9/166 (5%)
Query: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
H VN +G+ L++ S D V W G + L H VK ++ D L A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193
SA D + LWDV L L G++ S+ +++ + + SG +K +
Sbjct: 80 SASCDCTVRLWDVARAKCLRV---------LKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
+WD ++ L L GH D++++ + +GS D T+ +W L
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 63.5 bits (153), Expect = 6e-10
Identities = 41/160 (25%), Positives = 77/160 (48%), Gaps = 9/160 (5%)
Query: 171 IYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSS 230
+ S A + G ++++GS + + W+ R+ L +L GHT VK + DG S S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 231 DGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLI 290
D T+RLW + + +C+ + H V + + + SGG D+++ D+++ + L+
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
Query: 291 CEEKAPVLKMELDRSADPPPAIWVATT---KSTVNKWTLK 327
+ + +S+D P + T STV+ W L+
Sbjct: 144 VGHRDSI------QSSDFSPTVNCLATGSWDSTVHIWDLR 177
Score = 56.6 bits (135), Expect = 7e-08
Identities = 50/214 (23%), Positives = 83/214 (38%), Gaps = 16/214 (7%)
Query: 25 VEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC 84
V K ++ V + P +L + G D + +W V + + + H D +
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM---LRLLVGHRDSIQSSDFS 156
Query: 85 CNGKTLISASSDTTVKVWNAHK---GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQI 141
L + S D+TV +W+ L H + L Y+ L+AS D+ I
Sbjct: 157 PTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTI 215
Query: 142 FLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCA 201
+W T + L L G+ + S+A + + S ++++VWD T
Sbjct: 216 HIWKPTTSSLLI---------QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Query: 202 KLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
L LKG D DG +SG++D T R
Sbjct: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 49.7 bits (117), Expect = 9e-06
Identities = 34/167 (20%), Positives = 68/167 (40%), Gaps = 9/167 (5%)
Query: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175
H V + A++ D +++ + D ++ W+ + L L G+ +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR---------LGGHTGPVKFCR 70
Query: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
+ G + S S + +R+WD L LKGH +V+ + + D Q SG D +
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
LW + + + H + + + + + +G D ++ DLR
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 85.1 bits (209), Expect = 2e-16
Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 8/205 (3%)
Query: 45 LFTAGRDSIIRIWSVNQHKQDPYIA--SMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
+ +A RD I +W + + + + I ++ H+ +V+D+V+ +G+ +S S D T+++W
Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Query: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
+ G H V ++A++ D + S D+ I LW+ L TV
Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-----LGVCKYTVQDE 145
Query: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
S S S + N IIVS +K+++VW+ C GHT + + ++ DG
Sbjct: 146 SHS-EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204
Query: 223 TQCLSGSSDGTIRLWSLGQQRCIAT 247
+ C SG DG LW L + + + T
Sbjct: 205 SLCASGGKDGQAMLWDLNEGKHLYT 229
Score = 66.2 bits (160), Expect = 9e-11
Identities = 42/144 (29%), Positives = 71/144 (49%), Gaps = 10/144 (6%)
Query: 112 TLRTHKDYVKALAYAKD-KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDS 170
TL+ H +V +A +++ SA D+ I +W + +N + +L G+
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR----DETNYGIPQRALRGHSHF 65
Query: 171 IYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSS 230
+ + ++ G +SGS + LR+WD T + GHT +V ++ + D Q +SGS
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
Query: 231 DGTIRLW-SLGQQRCIATYRVHDE 253
D TI+LW +LG + Y V DE
Sbjct: 126 DKTIKLWNTLG----VCKYTVQDE 145
Score = 61.2 bits (147), Expect = 3e-09
Identities = 54/212 (25%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 43 NRLFTAG-RDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT--LISASSDTTV 99
NR +G RD I++W N Y E H++WV+ + N ++S D V
Sbjct: 117 NRQIVSGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 100 KVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT----------- 148
KVWN + H Y+ + + D L AS G D Q LWD+N
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234
Query: 149 -LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207
+ AL S N + +G I+ L G IIV ++V+ K
Sbjct: 235 IINALCFSPNRYWLCAATGPSIKIWDLE----GKIIVDELKQEVIST----------SSK 280
Query: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
+L + DG +G +D +R+W +
Sbjct: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
Score = 49.7 bits (117), Expect = 9e-06
Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 163 SLSGNKDSIYSLAMN-QLGTIIVSGSTEKVLRVW-----DPRTCAKLMKLKGHTDNVKAL 216
+L G+ + +A Q +I+S S +K + +W + L+GH+ V +
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
Query: 217 LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 276
+++ DG LSGS DGT+RLW L + H + V ++ + + SG RD+ I
Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 83.2 bits (204), Expect = 7e-16
Identities = 52/200 (26%), Positives = 90/200 (45%), Gaps = 9/200 (4%)
Query: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
H WV I + + ++ S+D T+K+W+ G +L H V+ + + +
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
Query: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193
S G D+Q+ WD+ + + G+ ++Y L ++ ++V+ S + R
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYH---------GHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE 253
+WD RT A + L GHT+ V + Q ++GS D TIRLW L + T H +
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373
Query: 254 GVWALQVNDAFTHVYSGGRD 273
V A+ ++ SG D
Sbjct: 374 SVRAVVLHPRHYTFASGSPD 393
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/193 (24%), Positives = 84/193 (43%), Gaps = 14/193 (7%)
Query: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104
LF+ G D ++ W + +K I H V + L L++ S D+T ++W+
Sbjct: 261 LFSCGEDKQVKCWDLEYNK---VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 105 HKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSL 164
+ TL H + V + + + + D I LWD L A VT L
Sbjct: 318 RTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD------LVAGKTRVT---L 368
Query: 165 SGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQ 224
+ +K S+ ++ ++ SGS + + + W + + L GH + L +N DG
Sbjct: 369 TNHKKSVRAVVLHPRHYTFASGSPDNI-KQWKFPDGSFIQNLSGHNAIINTLTVNSDGV- 426
Query: 225 CLSGSSDGTIRLW 237
+SG+ +GT+ LW
Sbjct: 427 LVSGADNGTMHLW 439
Score = 62.4 bits (150), Expect = 1e-09
Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 22/215 (10%)
Query: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90
+ V L L P ++ L T RDS RIW V + ++ HT+ V + +
Sbjct: 289 SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS---VHTLSGHTNAVATVRCQAAEPQI 345
Query: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150
I+ S DTT+++W+ G TL HK V+A+ AS D I W +
Sbjct: 346 ITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGS 404
Query: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL---- 206
+ +LSG+ I +L +N G ++VSG+ + +WD RT ++
Sbjct: 405 FI---------QNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAV 454
Query: 207 -KGHTDN---VKALLLNRDGTQCLSGSSDGTIRLW 237
G D+ + A ++ ++ L+ +D TI+++
Sbjct: 455 QPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/182 (21%), Positives = 71/182 (39%), Gaps = 9/182 (4%)
Query: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175
H +V+ +A + + DR I +WD+ AS SL+G+ ++ +
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDL-------ASGKLKL--SLTGHISTVRGVI 253
Query: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
++ + S +K ++ WD + GH V L L+ ++ S D T R
Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKA 295
+W + + + T H V ++ A + +G D I DL RV + K
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373
Query: 296 PV 297
V
Sbjct: 374 SV 375
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/119 (21%), Positives = 52/119 (43%)
Query: 164 LSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGT 223
+SG+ + +A+ V+GS ++ +++WD + + L GH V+ ++++
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
Query: 224 QCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
S D ++ W L + I Y H V+ L ++ + + RD D+R
Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 82.4 bits (202), Expect = 1e-15
Identities = 54/248 (21%), Positives = 117/248 (47%), Gaps = 12/248 (4%)
Query: 32 GVNALQLDPA-LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90
G+ AL L P+ N++ T G D + ++ + + +A+++ HT V +V + +
Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQ---ILATLKGHTKKVTSVVFHPSQDLV 279
Query: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150
SAS D T+++W+ C+ +R H+ V L+ + + S+ D+ D+ T
Sbjct: 280 FSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGR 339
Query: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHT 210
LT + + SL+ + G I +G+ + +++WD + + GH+
Sbjct: 340 VLTKVTDETSGCSLT-------CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS 392
Query: 211 DNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE-GVWALQVNDAFTHVYS 269
+ ++ + +G + + D +++LW L + + T ++ + V +L + + T++
Sbjct: 393 GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLAL 452
Query: 270 GGRDRKIY 277
GG D +IY
Sbjct: 453 GGTDVQIY 460
Score = 53.9 bits (128), Expect = 5e-07
Identities = 29/111 (26%), Positives = 54/111 (48%)
Query: 183 IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ 242
I++G +K + V+D + L LKGHT V +++ + S S D TIR+WS+
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 243 RCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEE 293
C+ R H+ V L ++ ++ S D+ +D++ + + +E
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE 347
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/219 (19%), Positives = 96/219 (43%), Gaps = 12/219 (5%)
Query: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149
+++ +D V V++ ++TL+ H V ++ + ++LV SA D I +W V
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP-- 294
Query: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209
N + ++ ++ L+++ G ++S S ++ D +T L K+
Sbjct: 295 -------NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE 347
Query: 210 TD--NVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHV 267
T ++ + DG +G+ D I++W L ++ +A + H + ++ ++ ++
Sbjct: 348 TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYL 407
Query: 268 YSGGRDRKIYCTDLRN-PDIRVLICEEKAPVLKMELDRS 305
+ D + DLR + + L + V + D+S
Sbjct: 408 ATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,598,358
Number of Sequences: 37866
Number of extensions: 1201599
Number of successful extensions: 6211
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 213
Number of HSP's successfully gapped in prelim test: 101
Number of HSP's that attempted gapping in prelim test: 3667
Number of HSP's gapped (non-prelim): 1435
length of query: 677
length of database: 18,247,518
effective HSP length: 109
effective length of query: 568
effective length of database: 14,120,124
effective search space: 8020230432
effective search space used: 8020230432
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.