Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 188528675
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188528675 slit homolog 1 [Homo sapiens]
(1534 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188528675 slit homolog 1 [Homo sapiens] 3236 0.0
gi|4759146 slit homolog 2 [Homo sapiens] 2183 0.0
gi|11321571 slit homolog 3 [Homo sapiens] 1949 0.0
gi|148833508 notch1 preproprotein [Homo sapiens] 227 8e-59
gi|110735443 delta-like 1 [Homo sapiens] 226 2e-58
gi|24041035 notch 2 preproprotein [Homo sapiens] 215 2e-55
gi|134244285 Notch homolog 3 [Homo sapiens] 211 6e-54
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 211 6e-54
gi|148886654 polydom [Homo sapiens] 211 6e-54
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 205 2e-52
gi|55770876 notch4 preproprotein [Homo sapiens] 204 4e-52
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 201 3e-51
gi|4557679 jagged 1 precursor [Homo sapiens] 200 8e-51
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 184 6e-46
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 184 7e-46
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 179 2e-44
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 178 3e-44
gi|112420992 crumbs homolog 2 [Homo sapiens] 174 5e-43
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 172 2e-42
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 169 2e-41
gi|122937283 6720455I24Rik homolog [Homo sapiens] 168 4e-41
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 159 3e-38
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 159 3e-38
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 157 7e-38
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 156 1e-37
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 152 2e-36
gi|40217825 slit and trk like 6 [Homo sapiens] 150 1e-35
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 148 5e-35
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 148 5e-35
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 146 2e-34
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 3236 bits (8390), Expect = 0.0
Identities = 1534/1534 (100%), Positives = 1534/1534 (100%)
Query: 1 MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP 60
MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP
Sbjct: 1 MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP 60
Query: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 240
RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT
Sbjct: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 240
Query: 241 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 300
QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL
Sbjct: 241 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 300
Query: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN
Sbjct: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
Query: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL
Sbjct: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
Query: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI
Sbjct: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
Query: 481 KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ 540
KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ
Sbjct: 481 KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ 540
Query: 541 STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ 600
STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ
Sbjct: 541 STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ 600
Query: 601 LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL 660
LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL
Sbjct: 601 LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL 660
Query: 661 QSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE 720
QSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE
Sbjct: 661 QSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE 720
Query: 721 EGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL 780
EGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL
Sbjct: 721 EGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL 780
Query: 781 STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH 840
STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH
Sbjct: 781 STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH 840
Query: 841 GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME 900
GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME
Sbjct: 841 GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME 900
Query: 901 GKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRD 960
GKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRD
Sbjct: 901 GKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRD 960
Query: 961 CEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC 1020
CEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC
Sbjct: 961 CEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC 1020
Query: 1021 VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC
Sbjct: 1021 VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
Query: 1081 SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA 1140
SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA
Sbjct: 1081 SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA 1140
Query: 1141 NCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDN 1200
NCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDN
Sbjct: 1141 NCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDN 1200
Query: 1201 GILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL 1260
GILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL
Sbjct: 1201 GILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL 1260
Query: 1261 SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN 1320
SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN
Sbjct: 1261 SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN 1320
Query: 1321 NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP 1380
NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP
Sbjct: 1321 NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP 1380
Query: 1381 CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA 1440
CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA
Sbjct: 1381 CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA 1440
Query: 1441 HCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQG 1500
HCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQG
Sbjct: 1441 HCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQG 1500
Query: 1501 LRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA 1534
LRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA
Sbjct: 1501 LRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA 1534
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 2183 bits (5656), Expect = 0.0
Identities = 1002/1516 (66%), Positives = 1227/1516 (80%), Gaps = 6/1516 (0%)
Query: 21 LLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKND 80
L+ A ++ ACPA C+C+G+TVDCHG L+++P+NIPRNTERL+LNGNNITRI K D
Sbjct: 15 LVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTD 74
Query: 81 FAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDL 140
FAGL+ LRVLQLMEN+I +ERGAF D+KELERLRLNRN L + PELLF L RLDL
Sbjct: 75 FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDL 134
Query: 141 SENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS 200
SEN IQAIPRKAFRGA D+KNLQLD NQISCIE+GAFRALR LEVLTLNNNNIT + V+S
Sbjct: 135 SENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS 194
Query: 201 FNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSE 260
FNHMPKLRTFRLHSN+L+CDCHLAWLS WLRQRP +GL+TQC GP+ LRG NVAEVQK E
Sbjct: 195 FNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKRE 254
Query: 261 FSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNG 320
F CSG ++ P+C++ CPA CTCSN IVDCRGKGLT IP NLPET+TEIRLE N
Sbjct: 255 FVCSGH-QSFMAPSCSVLH--CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT 311
Query: 321 IKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGL 380
IK IPPGAFSPY+KLRRIDLSNNQI+E+APDAFQGLRSLNSLVLYGNKIT+LP+ +F GL
Sbjct: 312 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 371
Query: 381 YTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP 440
++LQLLLLNANKINC+R DAFQDL NL+LLSLYDNK+Q++AKGTF+ LRAIQT+HLAQNP
Sbjct: 372 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP 431
Query: 441 FICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 500
FICDC+LKWLAD+L TNPIETSGARC SPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED
Sbjct: 432 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 491
Query: 501 YQ--LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEAT 558
Y+ L+ +C +D+ CP KCRCE V+CS+ KL KIPE IPQ TAELRLNNNE ++LEAT
Sbjct: 492 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT 551
Query: 559 GMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618
G+FKKL L+KIN SNNK+++IE+GAFEGA+ V+E+ LT+N+LE+++ MF+GL+ L+TL
Sbjct: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
Query: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678
MLR+NRI+C+ NDSF GL +VRLLSLYDNQITTV+PGAFDTL SLSTLNLLANPFNCNC
Sbjct: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY 671
Query: 679 LAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQEC 738
LAWLG WLRK++IVTGNPRCQ P FL++IP+QDVA DF C++G ++ C P +CP EC
Sbjct: 672 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC 731
Query: 739 ACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS 798
CLDTVVRCSNK L+ LPKGIP++VTELYLDGNQFTLVP +LS +K+L L+DLSNN+IS+
Sbjct: 732 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST 791
Query: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
LSN SF+NM+QL TLILSYN L+CIPP F GL+SLRLLSLHGNDIS + EG F D+++L
Sbjct: 792 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL 851
Query: 859 SHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPP 918
SHLAIGANPLYCDC+++WLS WVK+ YKEPGIARCAGP +M KLLLTTP+KKF CQGP
Sbjct: 852 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV 911
Query: 919 TLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGT 978
+ + AKC+ CLS+PC+N GTC++DP++ YRC CP G+KG+DC+V + +C S PC++GGT
Sbjct: 912 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT 971
Query: 979 CHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
CH +EGE+ F C C GFEG C VN DDC D+ C N CVDG+ NYTC CP +Y G+
Sbjct: 972 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE 1031
Query: 1039 ACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQC 1098
CE+ +D C+ DLNPCQH+++C+ TP G +C+C PGY G++C + DDC+D++C+NGA C
Sbjct: 1032 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
Query: 1099 MDEVNSYSCLCAEGYSGQLCEIPPHLPAPK-SPCEGTECQNGANCVDQGNRPVCQCLPGF 1157
D VN Y+C+C EGYSG CE P + P+ SPC+ +CQNGA C+ + N P+CQCLPG+
Sbjct: 1092 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1151
Query: 1158 GGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELY 1217
G +CEKL+SVNF+++++YLQ + P+ NITLQ++T ED+GILLY GD DHIAVELY
Sbjct: 1152 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY 1211
Query: 1218 QGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHY 1277
+G VR SYD GS+P+SAIYS ETINDG FH VEL+A DQ ++LS+DGG+P + N K
Sbjct: 1212 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS 1271
Query: 1278 TLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVP 1337
TLN ++PLYVGGMP N A+ R NGT FHGCIRNLYIN+ELQDF K M+ G++P
Sbjct: 1272 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP 1331
Query: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDAL 1397
GCEPC K C HG CQP++ G C C+ GW+G CDQ + PC G+KCVHG C+P++A
Sbjct: 1332 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF 1391
Query: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES 1457
SYSC+C +G+ G LC++ L PC+ ++C HG C+ SG +C C G++G+ C++E
Sbjct: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
Query: 1458 ECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTS 1517
CRG+ +RD++Q Q+GYA CQTT+ +S +ECRG C G CC LR KRRK++FEC+DG+S
Sbjct: 1452 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS 1511
Query: 1518 FAEEVEKPTKCGCALC 1533
F +EVEK KCGC C
Sbjct: 1512 FVDEVEKVVKCGCTRC 1527
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 1949 bits (5050), Expect = 0.0
Identities = 913/1538 (59%), Positives = 1141/1538 (74%), Gaps = 21/1538 (1%)
Query: 3 LTPGWGSSAGPVRPELWLLLWAAAWRLG--ASACPALCTCTGTTVDCHGTGLQAIPKNIP 60
+ PGW VR L L L A+ G A ACP CTC+ +VDCHG GL+A+P+ IP
Sbjct: 1 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Query: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
RN ERL+L+ NNITRI K DFAGLK LRVL L +NQ+ +ERGAF D+K+LERLRLN+N+
Sbjct: 61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120
Query: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
L +LPELLFQ+ L+RLDLSEN IQ IPRKAFRG TD+KNLQLD N ISCIE+GAFRAL
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
Query: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 240
R LE+LTLNNNNI+ I V+SFNHMPK+RT RLHSNHL+CDCHLAWLS WLRQR T+G FT
Sbjct: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240
Query: 241 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 300
C P LRG NVA+VQK E+ C P+C +S SCP+ CTCSN IVDCRGKGL
Sbjct: 241 LCMAPVHLRGFNVADVQKKEYVCPAPHS--EPPSCNANSISCPSPCTCSNNIVDCRGKGL 298
Query: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
IPANLPE + EIRLE N IK+IP GAF+ Y+KL+RID+S NQI++IAPDAFQGL+SL
Sbjct: 299 MEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLT 358
Query: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
SLVLYGNKIT++ +G+F GL +LQLLLLNANKINC+R + FQDLQNL+LLSLYDNK+Q++
Sbjct: 359 SLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI 418
Query: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
+KG F L++IQTLHLAQNPF+CDC+LKWLAD+L+ NPIETSGARC+SPRRLANKRI QI
Sbjct: 419 SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQI 478
Query: 481 KSKKFRCSAKEQYFIPGTEDYQ--LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI 538
KSKKFRCS G+EDY+ +SEC D+VCP KCRCE +V+CS+ KL +IP +
Sbjct: 479 KSKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHL 530
Query: 539 PQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTA 598
P+ +LRLN+NE+S+LEATG+FKKL +L+KINLSNNK+ E+ +GAF+GAASV EL LT
Sbjct: 531 PEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTG 590
Query: 599 NQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFD 658
NQLE++ +FRGL GL+TLMLR+N I C+ ND+F GL +VRLLSLYDN+ITT++PGAF
Sbjct: 591 NQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT 650
Query: 659 TLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 718
TL SLST+NLL+NPFNCNC LAWLG WLRKR+IV+GNPRCQ P FL++IP+QDVA DF
Sbjct: 651 TLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFT 710
Query: 719 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG 778
C+ G EE C P+CP++C C++TVVRCSNK LRALP+G+PK+VTELYL+GN T VP
Sbjct: 711 CD-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR 769
Query: 779 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLS 838
+LS ++L L+DLSNN IS L+N +F+NMS L+TLILSYN L+CIP AF GLRSLR+L+
Sbjct: 770 ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLT 829
Query: 839 LHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQD 898
LHGNDIS++ EG F D+TSLSHLA+G NPL+CDC LRWLS WVK GYKEPGIARC+ P+
Sbjct: 830 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEP 889
Query: 899 MEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKG 958
M +LLLTTP +F+C+GP + + AKC+ CLSSPC+N GTC DP+E+YRCACP YKG
Sbjct: 890 MADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKG 949
Query: 959 RDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGG 1018
+DC V +++C PC++GGTCH + F+CSCP GFEG C +N DDC D+ C N
Sbjct: 950 KDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNA 1009
Query: 1019 VCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGD 1078
CVDG+ NY C CP Y G+ C++++D C P+LN CQHEA+C+ G CEC+PGY+G
Sbjct: 1010 TCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGK 1069
Query: 1079 NCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP-APKSPCEGTECQ 1137
C + DDC H+C++GAQC+D +N Y+C C +G+SG CE PP + SPC+ ECQ
Sbjct: 1070 LCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQ 1129
Query: 1138 NGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTA 1197
NGA C+ P C+C PGF GP CEKL++VNFV +D+Y++ + P+ANI+LQV+T
Sbjct: 1130 NGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATD 1189
Query: 1198 EDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQM 1257
+DNGILLY GDND +A+ELYQGHVR+ YD S P + +YS ET+NDGQFH+VELV +Q
Sbjct: 1190 KDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQT 1249
Query: 1258 VNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNL 1317
+NL +D G+P ++ K + +PLY+GG+P +A R GFHGCI +
Sbjct: 1250 LNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEV 1309
Query: 1318 YINNELQDFTKTQMKP-GVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP 1376
INNELQDF + GV PGC+ C C HG+C+ +C C GW G CDQ
Sbjct: 1310 RINNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQE 1367
Query: 1377 ADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASG 1436
A PC GH+C HG+CV SY C+C +GY G LC+ A C +C HG C S
Sbjct: 1368 ARDPCLGHRCHHGKCV-ATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISD 1426
Query: 1437 TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQG 1496
+C+C PGFSGE C+QE+ C G VR+ + Q+GYA C T + +ECRG C G
Sbjct: 1427 QGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQ 1485
Query: 1497 CCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA 1534
CCQ R KRRK+ F+C+DG+SF EEVE+ +CGC C+
Sbjct: 1486 CCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS 1523
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 227 bits (578), Expect = 8e-59
Identities = 174/610 (28%), Positives = 240/610 (39%), Gaps = 105/610 (17%)
Query: 912 FECQGPPTLAVQA------KCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
+ C+ PP Q +C L + + CQN GTCHN Y C C +G+ G DC ++
Sbjct: 279 YNCRCPPEWTGQYCTEDVDECQL-MPNACQNGGTCHNTH-GGYNCVCVNGWTGEDCSENI 336
Query: 966 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV- 1024
D C+S C +G TCH + A F C CP G G C +N D C+ + C G C
Sbjct: 337 DDCASAACFHGATCHDRV---ASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPV 392
Query: 1025 -GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN 1083
G C CP Y G AC Q VD CS NPC+H +C+ T C+C+ GY G C +
Sbjct: 393 NGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEID 452
Query: 1084 QDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCV 1143
++C + CQN A C+D++ + C+C GY G CE+ C + C + C+
Sbjct: 453 VNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEV------NTDECASSPCLHNGRCL 506
Query: 1144 DQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGIL 1203
D+ N C+C GF G C+ ++ ST NG
Sbjct: 507 DKINEFQCECPTGFTGHLCQ------------------------YDVDECASTPCKNGAK 542
Query: 1204 LYNGDNDH--IAVELYQG-HVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL 1260
+G N + + E Y G H V D P Y + DG + F +
Sbjct: 543 CLDGPNTYTCVCTEGYTGTHCEVDIDECD-PDPCHYG--SCKDG------VATFTCLCRP 593
Query: 1261 SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN 1320
G T N S P GG D ++A L L GT C NL
Sbjct: 594 GYTGHHCETNIN------ECSSQPCRHGGTCQDRDNA--YLCFCLKGTTGPNCEINL--- 642
Query: 1321 NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP 1380
+ C C G C + G C CE G+ G C+ D
Sbjct: 643 -------------------DDCASSPCDSGTCL-DKIDGYECACEPGYTGSMCNINID-E 681
Query: 1381 CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA 1440
C G+ C +G ++C+C +GY C C C+HG C+ S G
Sbjct: 682 CAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSE---VNECNSNPCVHGACRDS-LNGY 737
Query: 1441 HCVCDPGFSGELCE-QESECRGDPVRD---FHQVQRGYAICQTTRPLSWVECR------- 1489
C CDPG+SG C+ +EC +P + + GY +C S C+
Sbjct: 738 KCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGY-VCTCREGFSGPNCQTNINECA 796
Query: 1490 -GSCPGQGCC 1498
C QG C
Sbjct: 797 SNPCLNQGTC 806
Score = 225 bits (574), Expect = 2e-58
Identities = 183/707 (25%), Positives = 261/707 (36%), Gaps = 131/707 (18%)
Query: 894 AGPQDMEGKLLLTTPAKKFEC-QGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCAC 952
A P + GK + T + + +C QG + + C+S+PCQN TC D + ++C C
Sbjct: 420 ANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCL-DQIGEFQCIC 478
Query: 953 PSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDH 1012
GY+G CEV+ D C+S PC + G C + E F C CPTGF G C + D+C
Sbjct: 479 MPGYEGVHCEVNTDECASSPCLHNGRCLDKINE---FQCECPTGFTGHLCQYDVDECAST 535
Query: 1013 ACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPD---------------------- 1050
C NG C+DG YTC C Y G CE +D C PD
Sbjct: 536 PCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGY 595
Query: 1051 -------------LNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQ 1097
PC+H C + C C+ G G NC N DDC C +G
Sbjct: 596 TGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT- 654
Query: 1098 CMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGF 1157
C+D+++ Y C C GY+G +C I C G C NG C D N C+C G+
Sbjct: 655 CLDKIDGYECACEPGYTGSMCNINI------DECAGNPCHNGGTCEDGINGFTCRCPEGY 708
Query: 1158 GGP-------ECEKLLSVNFVDRDTYLQFT-DLQ-NWPRANITLQVSTAEDNGILLYNGD 1208
P EC V+ RD+ + D W N + + E N +
Sbjct: 709 HDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV----- 763
Query: 1209 NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPM 1268
N ++ G+V + S P+ E ++ + + D + + P
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLN--QGTCIDDVAGYKCNCLLPY 821
Query: 1269 TMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTK 1328
T + +P GG S + + + TG+ G + IN +
Sbjct: 822 TGATCEVVLAPCAPSPCRNGGECRQ--SEDYESFSCVCPTGWQGQTCEVDINECV----- 874
Query: 1329 TQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD----GPCH-G 1383
PCR HG N G CHC+AG+ G +C+ D PCH G
Sbjct: 875 ----------LSPCR-----HGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNG 919
Query: 1384 HKCVHG------QCVP-------------------------LDAL-SYSCQCQDGYSGAL 1411
C G C+P D + SY+C C G+SG
Sbjct: 920 GSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIH 979
Query: 1412 CNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQV 1470
C C C +G G C+C PGF+G C+ + +EC P
Sbjct: 980 CENN---TPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTC 1036
Query: 1471 QRGYAICQTTRPLSWV--ECRGS---CPGQGCCQGLRLKRRKFTFEC 1512
Q G + T P + C+ C C G + + + C
Sbjct: 1037 QDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRC 1083
Score = 204 bits (518), Expect = 7e-52
Identities = 109/271 (40%), Positives = 133/271 (49%), Gaps = 29/271 (10%)
Query: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
F C PP Q + C S PC + GTC D YRC CP GY G +C+ + C
Sbjct: 1005 FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQ-DGCGSYRCTCPQGYTGPNCQNLVHWC 1063
Query: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC----------VDHACANGG 1018
S PC+NGG C + + C CP+G+ G C V + C V C +GG
Sbjct: 1064 DSSPCKNGGKCWQTHTQ---YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGG 1120
Query: 1019 VCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGD 1078
+CVD + C+C Y G CE LVD CSP +PCQ+ A C G C+C+ GY G
Sbjct: 1121 LCVDAGNTHHCRCQAGYTGSYCEDLVDECSP--SPCQNGATCTDYLGGYSCKCVAGYHGV 1178
Query: 1079 NCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI------PPHLPAPKSPCE 1132
NCSE D+C H CQNG C+D N+Y C C G G CEI PP P +SP
Sbjct: 1179 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP-- 1236
Query: 1133 GTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
+C N CVDQ C C PGF G CE
Sbjct: 1237 --KCFNNGTCVDQVGGYSCTCPPGFVGERCE 1265
Score = 196 bits (499), Expect = 1e-49
Identities = 97/258 (37%), Positives = 129/258 (50%), Gaps = 17/258 (6%)
Query: 914 CQGPPTL---AVQAKCDLCLSSP--CQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
C PP+ + + C P C++ GTCHN+ + YRC C + + G +CE C
Sbjct: 164 CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNE-VGSYRCVCRATHTGPNCERPYVPC 222
Query: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYT 1028
S PC+NGGTC D C+C GF G C N DDC + C NGG CVDGV Y
Sbjct: 223 SPSPCQNGGTCRPTG--DVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYN 280
Query: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR 1088
C+CP ++ G+ C + VD C N CQ+ C T G C C+ G+ G++CSEN DDC
Sbjct: 281 CRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCA 340
Query: 1089 DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQ--G 1146
C +GA C D V S+ C C G +G LC + C C G+NC
Sbjct: 341 SAACFHGATCHDRVASFYCECPHGRTGLLCHL-------NDACISNPCNEGSNCDTNPVN 393
Query: 1147 NRPVCQCLPGFGGPECEK 1164
+ +C C G+ GP C +
Sbjct: 394 GKAICTCPSGYTGPACSQ 411
Score = 190 bits (482), Expect = 1e-47
Identities = 91/244 (37%), Positives = 124/244 (50%), Gaps = 10/244 (4%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C +PC N G+C D + C C G++G CE ++ C+S PC NG C + D
Sbjct: 909 DDCRPNPCHNGGSC-TDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANC--TDCVD 965
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
+ +TC+CP GF G C NT DC + +C NGG CVDG+ ++TC CP + G C+ V+
Sbjct: 966 S-YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNE 1024
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYS 1106
C D PC H C RC C GY G NC C C+NG +C Y
Sbjct: 1025 C--DSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYR 1082
Query: 1107 CLCAEGYSGQLCEIPPHLPAPKSPCEGTE----CQNGANCVDQGNRPVCQCLPGFGGPEC 1162
C C G++G C++P + +G + CQ+G CVD GN C+C G+ G C
Sbjct: 1083 CECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYC 1142
Query: 1163 EKLL 1166
E L+
Sbjct: 1143 EDLV 1146
Score = 177 bits (450), Expect = 5e-44
Identities = 89/246 (36%), Positives = 120/246 (48%), Gaps = 22/246 (8%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C S PC+N C D ++ Y C CP+G+ G CE + C+ C NGGTC +G ++
Sbjct: 949 CASDPCRNGANC-TDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTC--VDGINS- 1004
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
FTC CP GF G C + ++C C +GG C DG G+Y C CP Y G C+ LV C
Sbjct: 1005 FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWC- 1063
Query: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR----------DHRCQNGAQC 1098
D +PC++ +C T RCEC G+ G C C CQ+G C
Sbjct: 1064 -DSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLC 1122
Query: 1099 MDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFG 1158
+D N++ C C GY+G CE C + CQNGA C D C+C+ G+
Sbjct: 1123 VDAGNTHHCRCQAGYTGSYCE------DLVDECSPSPCQNGATCTDYLGGYSCKCVAGYH 1176
Query: 1159 GPECEK 1164
G C +
Sbjct: 1177 GVNCSE 1182
Score = 176 bits (447), Expect = 1e-43
Identities = 98/252 (38%), Positives = 118/252 (46%), Gaps = 29/252 (11%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C SPCQN TC D L Y C C +GY G +C +D C S PC+NGGTC D
Sbjct: 1147 DECSPSPCQNGATC-TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCL-----D 1200
Query: 987 APFT--CSCPTGFEGPTCGVNTDDC---VDHA-----CANGGVCVDGVGNYTCQCPLQYE 1036
P T CSCP G +G C +N DDC VD C N G CVD VG Y+C CP +
Sbjct: 1201 LPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV 1260
Query: 1037 GKACEQLVDLCSPDLNPCQHEA--QCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQN 1094
G+ CE V+ C NPC CV + CEC G+ G C + C+ C+N
Sbjct: 1261 GERCEGDVNECLS--NPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKN 1318
Query: 1095 GAQCMDEVNS---YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVC 1151
G C N+ + C C G+ G CE C C NG C+ P C
Sbjct: 1319 GGTCAVASNTARGFICKCPAGFEGATCE------NDARTCGSLRCLNGGTCISGPRSPTC 1372
Query: 1152 QCLPGFGGPECE 1163
CL F GPEC+
Sbjct: 1373 LCLGPFTGPECQ 1384
Score = 171 bits (432), Expect = 7e-42
Identities = 93/279 (33%), Positives = 125/279 (44%), Gaps = 50/279 (17%)
Query: 929 CLSSPCQNQGTCH---NDPLEVYRCACPSGYKGRDCEVSLDS-CSSGPCENGGTCHAQEG 984
CLS+PC+N GTCH + Y C+C G+ G C LD+ C + PC NGGTC
Sbjct: 63 CLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTL 122
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
+ + C CP G+ G +C D C + CANGG C+ +Y C CP + G C Q V
Sbjct: 123 TE--YKCRCPPGWSGKSCQ-QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDV 179
Query: 1045 DLCSPDLNPCQHEAQC---VG--------TPDGPRCE----------------------- 1070
+ C C+H C VG T GP CE
Sbjct: 180 NECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDV 239
Query: 1071 -----CMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP 1125
C+PG+ G NC EN DDC + C+NG C+D VN+Y+C C ++GQ C
Sbjct: 240 THECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT----ED 295
Query: 1126 APKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
+ CQNG C + C C+ G+ G +C +
Sbjct: 296 VDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSE 334
Score = 127 bits (320), Expect = 6e-29
Identities = 74/235 (31%), Positives = 103/235 (43%), Gaps = 52/235 (22%)
Query: 973 CENGGTCHAQEGED--------------------------------------APFTCSCP 994
C NGG C A G + A + CSC
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA 90
Query: 995 TGFEGPTCGVNTDD-CVDHACANGGVC-VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
GF GP C D+ C+ + C NGG C + + Y C+CP + GK+C+Q D C+ N
Sbjct: 91 LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-ADPCAS--N 147
Query: 1053 PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDC--RDHRCQNGAQCMDEVNSYSCLCA 1110
PC + QC+ C C P + G C ++ ++C + C++G C +EV SY C+C
Sbjct: 148 PCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCR 207
Query: 1111 EGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGN-RPVCQCLPGFGGPECEK 1164
++G CE P PC + CQNG C G+ C CLPGF G CE+
Sbjct: 208 ATHTGPNCE------RPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEE 256
Score = 120 bits (302), Expect = 8e-27
Identities = 89/273 (32%), Positives = 119/273 (43%), Gaps = 50/273 (18%)
Query: 912 FECQGPPTLAVQAKCD----LCLSSPCQNQGTCHN-DPLEVYRCACPSGYKGRDCEVSLD 966
+ C PP V +C+ CLS+PC +GT + + + C C +G+ GR CE ++
Sbjct: 1251 YSCTCPPGF-VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVIN 1309
Query: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGN 1026
C PC+NGGTC F C CP GFEG TC + C C NGG C+ G +
Sbjct: 1310 GCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRS 1369
Query: 1027 YTCQCPLQYEGKACEQLVDLCSPDL--NPCQHEAQCVGTPDGP--RCECMPGYAGDNCSE 1082
TC C + G C+ SP L NPC ++ C T + P RC C +
Sbjct: 1370 PTCLCLGPFTGPECQ--FPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKF------- 1420
Query: 1083 NQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGAN- 1141
NG C + YS G +G+ +IPP P + CE ECQ A
Sbjct: 1421 -----------NGLLC--HILDYS---FGGGAGR--DIPP--PLIEEACELPECQEDAGN 1460
Query: 1142 --CVDQGNRPVCQCLPGFGGPECEKLLSVNFVD 1172
C Q N C G+ G +C S+NF D
Sbjct: 1461 KVCSLQCNNHAC----GWDGGDC----SLNFND 1485
Score = 66.2 bits (160), Expect = 2e-10
Identities = 57/215 (26%), Positives = 82/215 (38%), Gaps = 25/215 (11%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALS 1398
+ C C +G + G C C AG+ G++C + D C H C +G C+ L +
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEID-ECLSHPCQNGGTCLDLPN-T 1204
Query: 1399 YSCQCQDGYSGALC----NQAGALAEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGELC 1453
Y C C G G C + +P R +C + G C C PGF GE C
Sbjct: 1205 YKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERC 1264
Query: 1454 EQE-SECRGDP------------VRDFH-QVQRGYAICQTTRPLSWVECRGS-CPGQGCC 1498
E + +EC +P V DFH + + G+ + ++ C+G C G C
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVIN--GCKGKPCKNGGTC 1322
Query: 1499 QGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALC 1533
R F +C G A CG C
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCENDARTCGSLRC 1357
Score = 62.0 bits (149), Expect = 4e-09
Identities = 61/245 (24%), Positives = 82/245 (33%), Gaps = 62/245 (25%)
Query: 1341 PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSY 1399
PCR G C C C GW G C Q AD PC + C +G QC+P +A SY
Sbjct: 110 PCRN----GGTCDLLTLTEYKCRCPPGWSGKSCQQ-AD-PCASNPCANGGQCLPFEA-SY 162
Query: 1400 SCQCQDGYSGALCNQ---------------------------------AGALAE----PC 1422
C C + G C Q G E PC
Sbjct: 163 ICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPC 222
Query: 1423 RGLQCLHGH-CQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQVQRGYAICQTT 1480
C +G C+ +G C C PGF+G+ CE+ +C G+ ++ G
Sbjct: 223 SPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCR 282
Query: 1481 RPLSWV---------ECR---GSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKC 1528
P W EC+ +C G C + C +G + + E C
Sbjct: 283 CPPEWTGQYCTEDVDECQLMPNACQNGGTCHN---THGGYNCVCVNGWTGEDCSENIDDC 339
Query: 1529 GCALC 1533
A C
Sbjct: 340 ASAAC 344
Score = 60.8 bits (146), Expect = 1e-08
Identities = 34/115 (29%), Positives = 48/115 (41%), Gaps = 13/115 (11%)
Query: 1362 CHCEAGWVGLHCDQPA---------DGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALC 1412
C C +GW GL+CD P+ G C HG ++ C+CQ GY+G+ C
Sbjct: 1083 CECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYC 1142
Query: 1413 NQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
L + C C +G G C C G+ G C +E EC P ++
Sbjct: 1143 ED---LVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQN 1194
Score = 60.5 bits (145), Expect = 1e-08
Identities = 40/124 (32%), Positives = 50/124 (40%), Gaps = 13/124 (10%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLD---ALSYSCQ 1402
CL+G A C C +VG C P PC C + G C +D Y+C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQDP--NPCLSTPCKNAGTCHVVDRRGVADYACS 88
Query: 1403 CQDGYSGALCNQA---GALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESEC 1459
C G+SG LC L PCR G C C C PG+SG+ C+Q C
Sbjct: 89 CALGFSGPLCLTPLDNACLTNPCRN----GGTCDLLTLTEYKCRCPPGWSGKSCQQADPC 144
Query: 1460 RGDP 1463
+P
Sbjct: 145 ASNP 148
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/127 (29%), Positives = 52/127 (40%), Gaps = 16/127 (12%)
Query: 1347 CLHGICQPNATPGPM-------CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPL---DA 1396
CL C T + C C AG G C+ +G C G C +G + A
Sbjct: 1271 CLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVING-CKGKPCKNGGTCAVASNTA 1329
Query: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-- 1454
+ C+C G+ GA C A C L+CL+G SG + C+C F+G C+
Sbjct: 1330 RGFICKCPAGFEGATCEND---ARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFP 1386
Query: 1455 QESECRG 1461
S C G
Sbjct: 1387 ASSPCLG 1393
Score = 52.8 bits (125), Expect = 3e-06
Identities = 50/234 (21%), Positives = 71/234 (30%), Gaps = 64/234 (27%)
Query: 1337 PGCE----PCRKLYCLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQC 1391
P CE PC C +G C+P C C G+ G +C++ D C G+ C +G
Sbjct: 213 PNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD-CPGNNCKNGGA 271
Query: 1392 VPLDALSYSCQCQDGYSGALCNQ------------------------------------- 1414
+Y+C+C ++G C +
Sbjct: 272 CVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGED 331
Query: 1415 AGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQ--- 1471
+ C C HG +C C G +G LC C +P +
Sbjct: 332 CSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNP 391
Query: 1472 -RGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEK 1524
G AIC C G C Q + ECS G + E K
Sbjct: 392 VNGKAIC---------TCPSGYTGPACSQDVD--------ECSLGANPCEHAGK 428
Score = 49.7 bits (117), Expect = 2e-05
Identities = 52/200 (26%), Positives = 71/200 (35%), Gaps = 37/200 (18%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHC---DQPADGPCH-GHKC----VHGQC 1391
+ C C HG + C C G GL C D PC+ G C V+G+
Sbjct: 337 DDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKA 396
Query: 1392 VPLDALSYSCQCQDGYSGALCNQ----AGALAEPCRGLQCLHGHCQASGTKGA-HCVCDP 1446
+ C C GY+G C+Q A PC G C T G+ C C
Sbjct: 397 I--------CTCPSGYTGPACSQDVDECSLGANPCEHA----GKC--INTLGSFECQCLQ 442
Query: 1447 GFSGELCEQE-SECRGDPVRD----FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCC 1498
G++G CE + +EC +P ++ Q+ IC V C C C
Sbjct: 443 GYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP--GYEGVHCEVNTDECASSPCL 500
Query: 1499 QGLRLKRRKFTFECSDGTSF 1518
R + F+C T F
Sbjct: 501 HNGRCLDKINEFQCECPTGF 520
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 3/75 (4%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPC-HGHKCVH-GQCVPL-DALS 1398
C L CL+G + P C C + G C PA PC G+ C + G C P ++
Sbjct: 1352 CGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPF 1411
Query: 1399 YSCQCQDGYSGALCN 1413
Y C C ++G LC+
Sbjct: 1412 YRCLCPAKFNGLLCH 1426
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 226 bits (575), Expect = 2e-58
Identities = 101/235 (42%), Positives = 133/235 (56%), Gaps = 12/235 (5%)
Query: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
PC+N TC N Y C+C GY G CE+ +D C PC+NGG+C E ++C+
Sbjct: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS---YSCT 353
Query: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGV-GNYTCQCPLQYEGKACEQLVDLCSPDL 1051
CP GF G C ++ C D C NGG C D G Y+C+CP+ Y G CE+ +D CS
Sbjct: 354 CPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS-- 411
Query: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAE 1111
+PC + A+CV D C C G++G +C +N DDC C NG C D VN +SC C
Sbjct: 412 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP 471
Query: 1112 GYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
GY+G+ C AP S CE C NGA C ++G+R VC+C G+GGP C+ LL
Sbjct: 472 GYTGRNCS------APVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
Score = 169 bits (428), Expect = 2e-41
Identities = 88/244 (36%), Positives = 121/244 (49%), Gaps = 16/244 (6%)
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSG-PCENGGTCHAQEG 984
CD C+ P GTC + ++C C G+ G C L+ C+ PC+NG TC G
Sbjct: 254 CDECIRYPGCLHGTCQ----QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC-TNTG 308
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
+ + +TCSC G+ G TC + D+C C NGG C D +Y+C CP + GK CE
Sbjct: 309 QGS-YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA 367
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGP-RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN 1103
C+ PC + +C +PDG C C GY+G NC + D C C NGA+C+D +
Sbjct: 368 MTCAD--GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
Query: 1104 SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
+Y C C G+SG+ C+ C + C NG C D N C C PG+ G C
Sbjct: 426 AYLCRCQAGFSGRHCD------DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCS 479
Query: 1164 KLLS 1167
+S
Sbjct: 480 APVS 483
Score = 140 bits (352), Expect = 1e-32
Identities = 76/198 (38%), Positives = 91/198 (45%), Gaps = 11/198 (5%)
Query: 887 EPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDL----CLSSPCQNQGTCHN 942
E GI C P + T + C PP + C+L C PC N G C +
Sbjct: 326 ELGIDEC-DPSPCKNGGSCTDLENSYSCTCPPGFYGKI-CELSAMTCADGPCFNGGRCSD 383
Query: 943 DPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
P Y C CP GY G +CE +D CSS PC NG C G+ + C C GF G C
Sbjct: 384 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC-VDLGD--AYLCRCQAGFSGRHC 440
Query: 1003 GVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVG 1062
N DDC CANGG C DGV +++C CP Y G+ C V C + PC + A C
Sbjct: 441 DDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAPCHNGATCHE 498
Query: 1063 TPDGPRCECMPGYAGDNC 1080
CEC GY G NC
Sbjct: 499 RGHRYVCECARGYGGPNC 516
Score = 124 bits (311), Expect = 7e-28
Identities = 77/250 (30%), Positives = 100/250 (40%), Gaps = 58/250 (23%)
Query: 952 CPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVD 1011
C G+KG C + C G E G C D P C C G++G C D+C+
Sbjct: 212 CNPGWKGPYCTEPI--CLPGCDEQHGFC------DKPGECKCRVGWQGRYC----DECIR 259
Query: 1012 H------------------------------------ACANGGVCVD-GVGNYTCQCPLQ 1034
+ C NG C + G G+YTC C
Sbjct: 260 YPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPG 319
Query: 1035 YEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQN 1094
Y G CE +D C P +PC++ C + C C PG+ G C + C D C N
Sbjct: 320 YTGATCELGIDECDP--SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFN 377
Query: 1095 GAQCMDEVN-SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQC 1153
G +C D + YSC C GYSG CE C + C NGA CVD G+ +C+C
Sbjct: 378 GGRCSDSPDGGYSCRCPVGYSGFNCE------KKIDYCSSSPCSNGAKCVDLGDAYLCRC 431
Query: 1154 LPGFGGPECE 1163
GF G C+
Sbjct: 432 QAGFSGRHCD 441
Score = 105 bits (261), Expect = 4e-22
Identities = 55/164 (33%), Positives = 76/164 (46%), Gaps = 11/164 (6%)
Query: 893 CAGPQDMEGKLLLTTPAKKFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYR 949
CA G +P + C+ P + + K D C SSPC N C D + Y
Sbjct: 370 CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV-DLGDAYL 428
Query: 950 CACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC 1009
C C +G+ GR C+ ++D C+S PC NGGTC + F+C+CP G+ G C C
Sbjct: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPGYTGRNCSAPVSRC 485
Query: 1010 VDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNP 1053
C NG C + Y C+C Y G C+ L+ P+L P
Sbjct: 486 EHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL----PELPP 525
Score = 75.1 bits (183), Expect = 5e-13
Identities = 41/118 (34%), Positives = 54/118 (45%), Gaps = 9/118 (7%)
Query: 1339 CEPC-RKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDA 1396
C+ C R CLHG CQ C+C+ GW GL C+Q + H C +G C
Sbjct: 254 CDECIRYPGCLHGTCQQPW----QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ 309
Query: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
SY+C C+ GY+GA C + C C +G C C PGF G++CE
Sbjct: 310 GSYTCSCRPGYTGATCELG---IDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
Score = 66.2 bits (160), Expect = 2e-10
Identities = 43/139 (30%), Positives = 59/139 (42%), Gaps = 26/139 (18%)
Query: 1332 KPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQC 1391
+P +PGC+ HG C PG C C GW G +CD+ P C+HG C
Sbjct: 223 EPICLPGCDE------QHGFCDK---PGE-CKCRVGWQGRYCDECIRYP----GCLHGTC 268
Query: 1392 VPLDALSYSCQCQDGYSGALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGF 1448
+ C CQ+G+ G CNQ +PC+ C +G C C PG+
Sbjct: 269 ----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN----GATCTNTGQGSYTCSCRPGY 320
Query: 1449 SGELCEQE-SECRGDPVRD 1466
+G CE EC P ++
Sbjct: 321 TGATCELGIDECDPSPCKN 339
Score = 52.8 bits (125), Expect = 3e-06
Identities = 43/165 (26%), Positives = 58/165 (35%), Gaps = 12/165 (7%)
Query: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA----DGPCHGHKCVHGQCVP 1393
G + C C +G + C C G+ G C+ A DGPC G+C
Sbjct: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNG----GRCSD 383
Query: 1394 LDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC 1453
YSC+C GYSG C + + C C +G C C GFSG C
Sbjct: 384 SPDGGYSCRCPVGYSGFNCEKK---IDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHC 440
Query: 1454 EQE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1497
+ +C P + + G T P + S P C
Sbjct: 441 DDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRC 485
Score = 42.0 bits (97), Expect = 0.005
Identities = 27/81 (33%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
F C PP A C +PC N TCH Y C C GY G +C+ L
Sbjct: 465 FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR-YVCECARGYGGPNCQFLLPEL 523
Query: 969 SSGPCENGGTCHAQEGEDAPF 989
GP T EG+ PF
Sbjct: 524 PPGPAVVDLT-EKLEGQGGPF 543
Score = 35.8 bits (81), Expect = 0.33
Identities = 20/77 (25%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD----GPCHGHKCVHGQCVPLD 1395
+ C C +G + C C G+ G +C P PCH H +
Sbjct: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER----- 499
Query: 1396 ALSYSCQCQDGYSGALC 1412
Y C+C GY G C
Sbjct: 500 GHRYVCECARGYGGPNC 516
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 215 bits (548), Expect = 2e-55
Identities = 103/245 (42%), Positives = 132/245 (53%), Gaps = 21/245 (8%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C S PC N+GTC D L YRC+CP GY G++C+ ++ CS PC+N GTC ++ E
Sbjct: 1029 CSSHPCLNEGTCV-DGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQ- 1086
Query: 989 FTCSCPTGFEGPTCGVNTDDC----------VDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
C CP+G+ G C V C V+H C + GVC++ + CQCPL Y G
Sbjct: 1087 --CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGS 1144
Query: 1039 ACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQC 1098
CE+ +D C+ NPCQH A C G RCEC+PGY G NC D+C++ CQNG C
Sbjct: 1145 YCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTC 1202
Query: 1099 MDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFG 1158
+D VN + C C G G LCE G C NG C+D+ C+CLPGF
Sbjct: 1203 IDLVNHFKCSCPPGTRGLLCE-----ENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFA 1257
Query: 1159 GPECE 1163
G CE
Sbjct: 1258 GERCE 1262
Score = 209 bits (531), Expect = 2e-53
Identities = 108/265 (40%), Positives = 139/265 (52%), Gaps = 20/265 (7%)
Query: 906 TTPAKKFECQ------GPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGR 959
TT A +F C+ G +CD+ CQ+ GTC N P Y+C CP G+ G+
Sbjct: 160 TTVANQFSCKCLTGFTGQKCETDVNECDI--PGHCQHGGTCLNLPGS-YQCQCPQGFTGQ 216
Query: 960 DCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGV 1019
C+ C+ PC NGGTC Q G D F C+C GFEG TC N DDC +H C NGGV
Sbjct: 217 YCDSLYVPCAPSPCVNGGTCR-QTG-DFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGV 274
Query: 1020 CVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDN 1079
CVDGV Y C+CP Q+ G+ C + VD C N CQ+ C G C C+ G++GD+
Sbjct: 275 CVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDD 334
Query: 1080 CSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNG 1139
CSEN DDC C G+ C+D V S+SC+C EG +G LC + C C G
Sbjct: 335 CSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHL-------DDACISNPCHKG 387
Query: 1140 ANCVDQ--GNRPVCQCLPGFGGPEC 1162
A C + +C C G+ G +C
Sbjct: 388 ALCDTNPLNGQYICTCPQGYKGADC 412
Score = 201 bits (510), Expect = 6e-51
Identities = 105/295 (35%), Positives = 145/295 (49%), Gaps = 56/295 (18%)
Query: 912 FEC---QGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
F C +GP + ++ + CLS+PC + G C L Y+C C +G+ G +CEV + C
Sbjct: 704 FRCICPEGPHHPSCYSQVNECLSNPCIH-GNCTGG-LSGYKCLCDAGWVGINCEVDKNEC 761
Query: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYT 1028
S PC+NGGTC + + C+C GF+G C VN D+C + C N G C D + YT
Sbjct: 762 LSNPCQNGGTC---DNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYT 818
Query: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPD-------------GPRC------ 1069
C C L Y GK C+ ++ CSP NPC++ A C +P+ G RC
Sbjct: 819 CHCVLPYTGKNCQTVLAPCSP--NPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDE 876
Query: 1070 ---------------------ECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCL 1108
EC PG++G +C E+ DDC + CQNG CMD VN++SCL
Sbjct: 877 CISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCL 936
Query: 1109 CAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
C G++G C+ + C C+NG C D N C+C GF G CE
Sbjct: 937 CLPGFTGDKCQ------TDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCE 985
Score = 195 bits (495), Expect = 3e-49
Identities = 101/288 (35%), Positives = 133/288 (46%), Gaps = 56/288 (19%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Q + CLS PC+N GTC +D + Y C C +G+ G CE +++ C+ C NGGTC
Sbjct: 947 QTDMNECLSEPCKNGGTC-SDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTC--V 1003
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
+G ++ F+C CP GF G C ++C H C N G CVDG+G Y C CPL Y GK C+
Sbjct: 1004 DGINS-FSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQT 1062
Query: 1043 LVDLCS--------------------------------PDL--------------NPCQH 1056
LV+LCS P++ + CQH
Sbjct: 1063 LVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQH 1122
Query: 1057 EAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQ 1116
C+ + C+C GY G C E D+C + CQ+GA C D + Y C C GY G
Sbjct: 1123 SGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGV 1182
Query: 1117 LCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
CE C+ CQNG C+D N C C PG G CE+
Sbjct: 1183 NCEY------EVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEE 1224
Score = 194 bits (494), Expect = 4e-49
Identities = 104/270 (38%), Positives = 129/270 (47%), Gaps = 15/270 (5%)
Query: 894 AGPQDMEGKLLLTTPAKKFEC-QGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCAC 952
+ P + GK + T A EC +G + + C S PCQN TC D + + C C
Sbjct: 424 SNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCL-DKIGGFTCLC 482
Query: 953 PSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDH 1012
G+KG CE+ ++ C S PC N G C + F C CP GF GP C ++ DDC
Sbjct: 483 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNR---FQCLCPPGFTGPVCQIDIDDCSST 539
Query: 1013 ACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECM 1072
C NG C+D Y CQC + G CE+ +D C PD PC H QC D C C
Sbjct: 540 PCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPD--PC-HHGQCQDGIDSYTCICN 596
Query: 1073 PGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE 1132
PGY G CS+ D+C C N +C+D VN Y C C G SG CEI C
Sbjct: 597 PGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI------NFDDCA 650
Query: 1133 GTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
C +G C+D NR C C PGF G C
Sbjct: 651 SNPCIHGI-CMDGINRYSCVCSPGFTGQRC 679
Score = 194 bits (493), Expect = 6e-49
Identities = 90/240 (37%), Positives = 125/240 (52%), Gaps = 10/240 (4%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Q D C S+PC NQGTC +D + Y C C Y G++C+ L CS PCEN C
Sbjct: 793 QVNIDECASNPCLNQGTCFDD-ISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKES 851
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
++ +TC C G++G C ++ D+C+ C N G+C + G+Y C+CP + G CE+
Sbjct: 852 PNFES-YTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEE 910
Query: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
+D C NPCQ+ C+ + C C+PG+ GD C + ++C C+NG C D V
Sbjct: 911 DIDDCLA--NPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYV 968
Query: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
NSY+C C G+ G CE + C + C NG CVD N C C GF G C
Sbjct: 969 NSYTCKCQAGFDGVHCE------NNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFC 1022
Score = 191 bits (486), Expect = 4e-48
Identities = 90/239 (37%), Positives = 131/239 (54%), Gaps = 16/239 (6%)
Query: 930 LSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPF 989
+S PC N GTCH + Y C C G+ G++C+ + D+C S PC NG TC + F
Sbjct: 111 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ---F 166
Query: 990 TCSCPTGFEGPTCGVNTDDC-VDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
+C C TGF G C + ++C + C +GG C++ G+Y CQCP + G+ C+ L C+
Sbjct: 167 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCA 226
Query: 1049 PDLNPCQHEAQCVGTPDGP-RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
P +PC + C T D C C+PG+ G C N DDC +HRCQNG C+D VN+Y+C
Sbjct: 227 P--SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNC 284
Query: 1108 LCAEGYSGQLC--EIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
C ++GQ C ++ L P + CQNG C ++ C C+ G+ G +C +
Sbjct: 285 RCPPQWTGQFCTEDVDECLLQPNA------CQNGGTCANRNGGYGCVCVNGWSGDDCSE 337
Score = 190 bits (483), Expect = 8e-48
Identities = 97/260 (37%), Positives = 132/260 (50%), Gaps = 19/260 (7%)
Query: 912 FECQGPPTLAVQ---AKCDLCLSSP--CQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLD 966
+ C+ PP Q D CL P CQN GTC N Y C C +G+ G DC ++D
Sbjct: 282 YNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRN-GGYGCVCVNGWSGDDCSENID 340
Query: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV-- 1024
C+ C G TC + A F+C CP G G C ++ D C+ + C G +C
Sbjct: 341 DCAFASCTPGSTCIDRV---ASFSCMCPEGKAGLLCHLD-DACISNPCHKGALCDTNPLN 396
Query: 1025 GNYTCQCPLQYEGKACEQLVDLCS-PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN 1083
G Y C CP Y+G C + VD C+ + NPC+H +CV T CEC+ GYAG C +
Sbjct: 397 GQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMD 456
Query: 1084 QDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCV 1143
++C CQN A C+D++ ++CLC G+ G CE+ + C+ C N CV
Sbjct: 457 INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCEL------EINECQSNPCVNNGQCV 510
Query: 1144 DQGNRPVCQCLPGFGGPECE 1163
D+ NR C C PGF GP C+
Sbjct: 511 DKVNRFQCLCPPGFTGPVCQ 530
Score = 185 bits (470), Expect = 3e-46
Identities = 89/262 (33%), Positives = 133/262 (50%), Gaps = 13/262 (4%)
Query: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
+ C+ PP + + D CL++PCQN G+C D + + C C G+ G C+ ++ C
Sbjct: 895 YMCECPPGFSGMDCEEDIDDCLANPCQNGGSCM-DGVNTFSCLCLPGFTGDKCQTDMNEC 953
Query: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYT 1028
S PC+NGGTC +TC C GF+G C N ++C + +C NGG CVDG+ +++
Sbjct: 954 LSEPCKNGGTCSDYVNS---YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFS 1010
Query: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR 1088
C CP+ + G C ++ CS +PC +E CV RC C GY G NC + C
Sbjct: 1011 CLCPVGFTGSFCLHEINECSS--HPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCS 1068
Query: 1089 DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTE----CQNGANCVD 1144
C+N C+ + CLC G++G C++P + G CQ+ C++
Sbjct: 1069 RSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCIN 1128
Query: 1145 QGNRPVCQCLPGFGGPECEKLL 1166
GN CQC G+ G CE+ L
Sbjct: 1129 AGNTHYCQCPLGYTGSYCEEQL 1150
Score = 184 bits (466), Expect = 7e-46
Identities = 84/243 (34%), Positives = 124/243 (51%), Gaps = 16/243 (6%)
Query: 929 CLSSPCQNQGTCHNDP-LEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDA 987
C +PC+N C P E Y C C G++G+ C + +D C S PC N G CH +G
Sbjct: 837 CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGS-- 894
Query: 988 PFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLC 1047
+ C CP GF G C + DDC+ + C NGG C+DGV ++C C + G C+ ++ C
Sbjct: 895 -YMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNEC 953
Query: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
+ PC++ C + C+C G+ G +C N ++C + C NG C+D +NS+SC
Sbjct: 954 LSE--PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC 1011
Query: 1108 LCAEGYSGQLC--EIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
LC G++G C EI + C C N CVD C C G+ G C+ L
Sbjct: 1012 LCPVGFTGSFCLHEI--------NECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTL 1063
Query: 1166 LSV 1168
+++
Sbjct: 1064 VNL 1066
Score = 164 bits (416), Expect = 5e-40
Identities = 80/241 (33%), Positives = 118/241 (48%), Gaps = 14/241 (5%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C SSPC N G C D + Y+C C G G +CE++ D C+S PC +G +G +
Sbjct: 609 DECYSSPCLNDGRCI-DLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHG---ICMDGIN 664
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
++C C GF G C ++ D+C + C G C++GV + C CP +C V+
Sbjct: 665 R-YSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNE 723
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYS 1106
C NPC H C G G +C C G+ G NC ++++C + CQNG C + VN Y
Sbjct: 724 CLS--NPCIH-GNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR 780
Query: 1107 CLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
C C +G+ G C++ C C N C D + C C+ + G C+ +L
Sbjct: 781 CTCKKGFKGYNCQV------NIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVL 834
Query: 1167 S 1167
+
Sbjct: 835 A 835
Score = 164 bits (415), Expect = 6e-40
Identities = 93/272 (34%), Positives = 124/272 (45%), Gaps = 37/272 (13%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
+ + D C S+PCQ+ TC +D + YRC C GY+G +CE +D C + PC+NGGTC
Sbjct: 1147 EEQLDECASNPCQHGATC-SDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDL 1205
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCVDGVGNYTCQCPLQYEGKACE 1041
F CSCP G G C N DDC C NGG C+D +G Y+C+C + G+ CE
Sbjct: 1206 VNH---FKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Query: 1042 QLVDLCSPDLNPCQHEA--QCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM 1099
++ C NPC E C+ + C C + G +C D C C NG C
Sbjct: 1263 GDINECLS--NPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCA 1320
Query: 1100 DEVN---SYSCLCAEGYSGQLCEIP--------------------PHLPAPK---SPCEG 1133
N + C C G+SG C+ P+P+ S C
Sbjct: 1321 VASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCAS 1380
Query: 1134 TECQNGANCVDQGNRPV--CQCLPGFGGPECE 1163
+ CQ+G +C Q P CQC P F G CE
Sbjct: 1381 SPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE 1412
Score = 159 bits (401), Expect = 3e-38
Identities = 80/240 (33%), Positives = 113/240 (47%), Gaps = 15/240 (6%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C S+PC+ TC N + +RC CP G C ++ C S PC +G G
Sbjct: 684 DECASNPCRKGATCING-VNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG-- 740
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
+ C C G+ G C V+ ++C+ + C NGG C + V Y C C ++G C+ +D
Sbjct: 741 --YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDE 798
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN--S 1104
C+ NPC ++ C G C C+ Y G NC C + C+N A C + N S
Sbjct: 799 CAS--NPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFES 856
Query: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
Y+CLCA G+ GQ C I C C N C + +C+C PGF G +CE+
Sbjct: 857 YTCLCAPGWQGQRCTIDI------DECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEE 910
Score = 112 bits (281), Expect = 2e-24
Identities = 76/254 (29%), Positives = 105/254 (41%), Gaps = 26/254 (10%)
Query: 912 FECQGPPT---LAVQAKCDLCLSSP-CQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
F+C PP L + D C P C N G C D + Y C C G+ G CE ++
Sbjct: 1209 FKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCM-DRIGGYSCRCLPGFAGERCEGDINE 1267
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCV---DGV 1024
C S PC + G+ + + + C C + F G C D C C NGG C +
Sbjct: 1268 CLSNPCSSEGSLDCIQLTN-DYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMP 1326
Query: 1025 GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQ 1084
+ C+CP + G C+ S C+ QCV T GPRC C + + +
Sbjct: 1327 DGFICRCPPGFSGARCQS-----SCGQVKCRKGEQCVHTASGPRCFC------PSPRDCE 1375
Query: 1085 DDCRDHRCQNGAQCMDEVNS--YSCLCAEGYSGQLCEIPPHLPA-PKSPCEGTECQNGAN 1141
C CQ+G C + YSC CA +SG CE+ P+ P + C C + A
Sbjct: 1376 SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKAR 1435
Query: 1142 ---CVDQGNRPVCQ 1152
C + N CQ
Sbjct: 1436 DGVCDEACNSHACQ 1449
Score = 110 bits (276), Expect = 8e-24
Identities = 75/236 (31%), Positives = 93/236 (39%), Gaps = 43/236 (18%)
Query: 968 CSSG--PCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDG-- 1023
C G PC N G C C CP GF G C + D C + C NGG CV
Sbjct: 28 CRDGYEPCVNEGMCVTYHNGTG--YCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAM 84
Query: 1024 VGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC-VGTPDGPRCECMPGYAGDNCSE 1082
+G TC+C + G+ C+ PC + C + + D C C G+ G C
Sbjct: 85 LGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW 144
Query: 1083 NQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCE-------IPPH-------LPAPK 1128
D C H C NG+ C N +SC C G++GQ CE IP H L P
Sbjct: 145 T-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG 203
Query: 1129 S-------------------PCEGTECQNGANCVDQGNRPV-CQCLPGFGGPECEK 1164
S PC + C NG C G+ C CLPGF G CE+
Sbjct: 204 SYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCER 259
Score = 102 bits (255), Expect = 2e-21
Identities = 77/264 (29%), Positives = 100/264 (37%), Gaps = 39/264 (14%)
Query: 929 CLSSPCQNQGTCHNDPL-EVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDA 987
CLS+PC ++G+ L Y C C S + GR CE +D C PC NGGTC
Sbjct: 1268 CLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD 1327
Query: 988 PFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLC 1047
F C CP GF G C C C G CV C CP + CE C
Sbjct: 1328 GFICRCPPGFSGARC---QSSCGQVKCRKGEQCVHTASGPRCFCP---SPRDCE---SGC 1378
Query: 1048 SPDLNPCQHEAQCVGTPDGP--RCECMPGYAGDNC-------SENQDDCRDHRCQNGAQ- 1097
+ +PCQH C P C+C P ++G C S C C + A+
Sbjct: 1379 AS--SPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARD 1436
Query: 1098 --CMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPC---EGTECQNGANCVD-------- 1144
C + NS++C G E P + PC +C N V+
Sbjct: 1437 GVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFEC 1496
Query: 1145 QGNRPVCQ----CLPGFGGPECEK 1164
QGN C+ C F C++
Sbjct: 1497 QGNSKTCKYDKYCADHFKDNHCDQ 1520
Score = 68.9 bits (167), Expect = 3e-11
Identities = 47/163 (28%), Positives = 64/163 (39%), Gaps = 41/163 (25%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDAL-S 1398
+ C CL+G + G C C G+ G+ C++ D C C HGQC D + S
Sbjct: 534 DDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN-CDPDPCHHGQCQ--DGIDS 590
Query: 1399 YSCQCQDGYSGALCN----------------------------QAGALA-------EPCR 1423
Y+C C GY GA+C+ Q G + C
Sbjct: 591 YTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCA 650
Query: 1424 GLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVR 1465
C+HG C G CVC PGF+G+ C + EC +P R
Sbjct: 651 SNPCIHGICM-DGINRYSCVCSPGFTGQRCNIDIDECASNPCR 692
Score = 67.0 bits (162), Expect = 1e-10
Identities = 49/171 (28%), Positives = 69/171 (40%), Gaps = 15/171 (8%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALS 1398
+ C C HG + G C C G+ G++C+ D C C +G C+ L
Sbjct: 1151 DECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVD-ECQNQPCQNGGTCIDL-VNH 1208
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-S 1457
+ C C G G LC + + + RG CL+G G C C PGF+GE CE + +
Sbjct: 1209 FKCSCPPGTRGLLCEEN--IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDIN 1266
Query: 1458 ECRGDPVR-----DFHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQG 1500
EC +P D Q+ Y +C + C CP C G
Sbjct: 1267 ECLSNPCSSEGSLDCIQLTNDY-LCVCRSAFTGRHCETFVDVCPQMPCLNG 1316
Score = 65.1 bits (157), Expect = 5e-10
Identities = 38/116 (32%), Positives = 50/116 (43%), Gaps = 15/116 (12%)
Query: 1362 CHCEAGWVGLHCDQP---------ADGPCHGHKCVH-GQCVPLDALSYSCQCQDGYSGAL 1411
C C +GW G +CD P G H C H G C+ Y CQC GY+G+
Sbjct: 1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSY 1145
Query: 1412 CNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
C + + C C HG + G C C PG+ G CE E EC+ P ++
Sbjct: 1146 CEEQ---LDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQN 1198
Score = 61.2 bits (147), Expect = 7e-09
Identities = 40/124 (32%), Positives = 55/124 (44%), Gaps = 12/124 (9%)
Query: 1347 CLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLDALSYS 1400
C CQ +AT G C C G+ G+HC+ + C + CV+ GQCV +
Sbjct: 460 CHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEIN-ECQSNPCVNNGQCVD-KVNRFQ 517
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
C C G++G +C + C CL+G G C C GF+G LCE+ C
Sbjct: 518 CLCPPGFTGPVCQID---IDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNC 574
Query: 1460 RGDP 1463
DP
Sbjct: 575 DPDP 578
Score = 60.8 bits (146), Expect = 1e-08
Identities = 39/125 (31%), Positives = 54/125 (43%), Gaps = 9/125 (7%)
Query: 1340 EPCRKLYCLHG-ICQPNATPGPM-CHCEAGWVGLHCDQPADGPCH-GHKCVH-GQCVPLD 1395
+PC K C +G C A G C C +G+ G C PC C++ G C L
Sbjct: 66 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 125
Query: 1396 ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ 1455
+Y C CQ G++G C A C C +G + C C GF+G+ CE
Sbjct: 126 RDTYECTCQVGFTGKECQWTDA----CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET 181
Query: 1456 E-SEC 1459
+ +EC
Sbjct: 182 DVNEC 186
Score = 60.8 bits (146), Expect = 1e-08
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 7/107 (6%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCV-HGQCVPLDALSYSCQCQDGYSGALCNQAGALAE 1420
C C GW G C D C C+ HG C SY C+C G+SG C + +
Sbjct: 859 CLCAPGWQGQRCTIDID-ECISKPCMNHGLCHNTQG-SYMCECPPGFSGMDCEED---ID 913
Query: 1421 PCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
C C +G G C+C PGF+G+ C+ + +EC +P ++
Sbjct: 914 DCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKN 960
Score = 60.1 bits (144), Expect = 2e-08
Identities = 49/162 (30%), Positives = 68/162 (41%), Gaps = 24/162 (14%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCD---QPADGPCHGHKCVHG-QCVPLD 1395
+ C C +G C C G+ G C+ D P H C HG C+ L
Sbjct: 146 DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGH---CQHGGTCLNLP 202
Query: 1396 ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELCE 1454
SY CQC G++G C+ +L PC C++G C+ +G C C PGF G CE
Sbjct: 203 G-SYQCQCPQGFTGQYCD---SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCE 258
Query: 1455 QE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQ 1495
+ +C H+ Q G +C ++ CR CP Q
Sbjct: 259 RNIDDCPN------HRCQNG-GVC--VDGVNTYNCR--CPPQ 289
Score = 59.3 bits (142), Expect = 3e-08
Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 6/120 (5%)
Query: 1346 YCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQ 1404
+C HG N C C G+ G +CD PC CV+G C ++ C C
Sbjct: 191 HCQHGGTCLNLPGSYQCQCPQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCL 249
Query: 1405 DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC-EQESECRGDP 1463
G+ G+ C + + C +C +G G +C C P ++G+ C E EC P
Sbjct: 250 PGFEGSTCERN---IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQP 306
Score = 58.9 bits (141), Expect = 4e-08
Identities = 36/119 (30%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 1347 CLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
C H G+C NA C C G+ G +C++ D C + C HG Y C+C
Sbjct: 1120 CQHSGVCI-NAGNTHYCQCPLGYTGSYCEEQLD-ECASNPCQHGATCSDFIGGYRCECVP 1177
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDP 1463
GY G C + C+ C +G C C PG G LCE+ +C P
Sbjct: 1178 GYQGVNCEYE---VDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGP 1233
Score = 58.5 bits (140), Expect = 5e-08
Identities = 50/207 (24%), Positives = 71/207 (34%), Gaps = 56/207 (27%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD----GPC-HGHKCVHG----Q 1390
+PC HG+C N MC C G+ G+ C++ D PC +G C+ G
Sbjct: 880 KPCMN----HGLCH-NTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFS 934
Query: 1391 CVPLDAL----------------------------SYSCQCQDGYSGALCNQAGALAEPC 1422
C+ L SY+C+CQ G+ G C C
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENN---INEC 991
Query: 1423 RGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQVQRGYAICQTTR 1481
C +G G C+C GF+G C E +EC P + G + +
Sbjct: 992 TESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSC 1051
Query: 1482 PLSWV--EC--------RGSCPGQGCC 1498
PL + C R C +G C
Sbjct: 1052 PLGYTGKNCQTLVNLCSRSPCKNKGTC 1078
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/130 (31%), Positives = 52/130 (40%), Gaps = 14/130 (10%)
Query: 1347 CLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS--Y 1399
C C P +T C C G GL C D C + C G + L+ Y
Sbjct: 342 CAFASCTPGSTCIDRVASFSCMCPEGKAGLLCH--LDDACISNPCHKGALCDTNPLNGQY 399
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQASGTKGA-HCVCDPGFSGELCEQE- 1456
C C GY GA C + C H G C T GA HC C G++G CE +
Sbjct: 400 ICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV--NTDGAFHCECLKGYAGPRCEMDI 457
Query: 1457 SECRGDPVRD 1466
+EC DP ++
Sbjct: 458 NECHSDPCQN 467
Score = 55.5 bits (132), Expect = 4e-07
Identities = 53/218 (24%), Positives = 79/218 (36%), Gaps = 53/218 (24%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCD----QPADGPC----------HGHKCV 1387
C C+HG C + G C C+AGWVG++C+ + PC +G++C
Sbjct: 724 CLSNPCIHGNCTGGLS-GYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCT 782
Query: 1388 ------------------------HGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCR 1423
G C D Y+C C Y+G C + PC
Sbjct: 783 CKKGFKGYNCQVNIDECASNPCLNQGTCFD-DISGYTCHCVLPYTGKNCQ---TVLAPCS 838
Query: 1424 GLQCLHGH-CQASGTKGAH-CVCDPGFSGELCEQE-SECRGDPVRDF---HQVQRGYAIC 1477
C + C+ S ++ C+C PG+ G+ C + EC P + H Q Y +C
Sbjct: 839 PNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSY-MC 897
Query: 1478 QTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFEC 1512
+ S ++C C C G TF C
Sbjct: 898 ECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSC 935
Score = 54.3 bits (129), Expect = 9e-07
Identities = 36/114 (31%), Positives = 51/114 (44%), Gaps = 15/114 (13%)
Query: 1347 CLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
CL+G C + C C+ G+ G C Q D C H C +G A +SC+C
Sbjct: 115 CLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDA-CLSHPCANGSTCTTVANQFSCKCLT 172
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGT----KGAH-CVCDPGFSGELCE 1454
G++G C C + GHCQ GT G++ C C GF+G+ C+
Sbjct: 173 GFTGQKCETD---VNECD----IPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD 219
Score = 52.4 bits (124), Expect = 3e-06
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 1341 PCRKLYCLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
PC C++G C+ C+C G+ G C++ D C H+C +G +Y
Sbjct: 224 PCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDD-CPNHRCQNGGVCVDGVNTY 282
Query: 1400 SCQCQDGYSGALCNQ--AGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ 1455
+C+C ++G C + L +P C +G A+ G CVC G+SG+ C +
Sbjct: 283 NCRCPPQWTGQFCTEDVDECLLQP---NACQNGGTCANRNGGYGCVCVNGWSGDDCSE 337
Score = 49.7 bits (117), Expect = 2e-05
Identities = 37/135 (27%), Positives = 55/135 (40%), Gaps = 19/135 (14%)
Query: 1361 MCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDAL--SYSCQCQDGYSGALCNQAGA 1417
+C C + + G HC+ D C C++G C + + C+C G+SGA C +
Sbjct: 1289 LCVCRSAFTGRHCETFVD-VCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCG 1347
Query: 1418 LAEPCRGLQCLHGHCQASGTKGAHCV----CDPGFSGELCEQESECRGDPVRDFHQVQRG 1473
+ +G QC+H ASG + C C+ G + C+ C Q Q
Sbjct: 1348 QVKCRKGEQCVH---TASGPR-CFCPSPRDCESGCASSPCQHGGSCH-------PQRQPP 1396
Query: 1474 YAICQTTRPLSWVEC 1488
Y CQ P S C
Sbjct: 1397 YYSCQCAPPFSGSRC 1411
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/104 (25%), Positives = 39/104 (37%), Gaps = 6/104 (5%)
Query: 1362 CHCEAGWVGLHCDQPADGPC--HGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALA 1419
C C W G C + D C + C +G Y C C +G+SG C++
Sbjct: 284 CRCPPQWTGQFCTEDVD-ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSEN---I 339
Query: 1420 EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDP 1463
+ C C G C+C G +G LC + C +P
Sbjct: 340 DDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNP 383
Score = 40.4 bits (93), Expect = 0.013
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 7/72 (9%)
Query: 1386 CVH-GQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQASGTKG-AHC 1442
CV+ G CV + C+C +G+ G C +PC +C + G C A G A C
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLGEYCQH----RDPCEKNRCQNGGTCVAQAMLGKATC 90
Query: 1443 VCDPGFSGELCE 1454
C GF+GE C+
Sbjct: 91 RCASGFTGEDCQ 102
Score = 38.5 bits (88), Expect = 0.051
Identities = 37/154 (24%), Positives = 55/154 (35%), Gaps = 35/154 (22%)
Query: 1396 ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ 1455
A +++ QC+DGY EPC G C +C C GF GE C+
Sbjct: 21 APAHALQCRDGY------------EPCVN----EGMCVTYHNGTGYCKCPEGFLGEYCQH 64
Query: 1456 ESECRGDPVRD----FHQVQRGYAICQTTRPLSWVECRGS----------CPGQGCCQGL 1501
C + ++ Q G A C+ + +C+ S C G C L
Sbjct: 65 RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHML 124
Query: 1502 RLKRRKFTFECSDGTSF-AEEVEKPTKCGCALCA 1534
+ T+EC+ F +E + C CA
Sbjct: 125 ----SRDTYECTCQVGFTGKECQWTDACLSHPCA 154
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 211 bits (536), Expect = 6e-54
Identities = 104/263 (39%), Positives = 135/263 (51%), Gaps = 16/263 (6%)
Query: 908 PAKKFECQGPPTL---AVQAKCDLC-LSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEV 963
P +F C PP + ++ D C + PC++ GTC N P +RC CP+GY G CE
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS-FRCQCPAGYTGPLCEN 196
Query: 964 SLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDG 1023
C+ PC NGGTC ++ D + C+C GFEG C VN DDC H C NGG CVDG
Sbjct: 197 PAVPCAPSPCRNGGTC--RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDG 254
Query: 1024 VGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN 1083
V Y CQCP ++ G+ C + VD C N C + C T G C C+ G+ G++CS+N
Sbjct: 255 VNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQN 314
Query: 1084 QDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCV 1143
DDC C +GA C D V S+ C C G +G LC + C C A C
Sbjct: 315 IDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHL-------DDACVSNPCHEDAICD 367
Query: 1144 DQ--GNRPVCQCLPGFGGPECEK 1164
R +C C PGF G C++
Sbjct: 368 TNPVNGRAICTCPPGFTGGACDQ 390
Score = 201 bits (511), Expect = 5e-51
Identities = 96/234 (41%), Positives = 125/234 (53%), Gaps = 14/234 (5%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
CLS PC+NQ TC D + + C C +G+ G CEV +D C S PC NGG C +
Sbjct: 435 CLSGPCRNQATCL-DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNG--- 490
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
F+C+CP+GF G TC ++ D+C C NG CVD Y C+C +EG C++ VD CS
Sbjct: 491 FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS 550
Query: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCL 1108
PD PC H +CV C C PGY G C D+CR C++G +C+D V+ Y C
Sbjct: 551 PD--PC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCR 607
Query: 1109 CAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
C G +G CE+ +PC C++G N D C C PGF GP C
Sbjct: 608 CPSGTTGVNCEVNID-DCASNPCTFGVCRDGINRYD------CVCQPGFTGPLC 654
Score = 187 bits (474), Expect = 9e-47
Identities = 94/265 (35%), Positives = 134/265 (50%), Gaps = 18/265 (6%)
Query: 908 PAKKFECQGPPTLAVQAKCDL---CLSSPCQNQGTCHNDPL---EVYRCACPSGYKGRDC 961
P+++ C PP V +C L C S PC +G C + + + C CP G++G DC
Sbjct: 59 PSREAACLCPPGW-VGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
Query: 962 EVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC-VDHACANGGVC 1020
+ D C S PC +G C G D F CSCP G++G +C + D+C V C +GG C
Sbjct: 118 SLP-DPCLSSPCAHGARCSV--GPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTC 174
Query: 1021 VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPD-GPRCECMPGYAGDN 1079
++ G++ CQCP Y G CE C+P +PC++ C + D C C+PG+ G N
Sbjct: 175 LNTPGSFRCQCPAGYTGPLCENPAVPCAP--SPCRNGGTCRQSGDLTYDCACLPGFEGQN 232
Query: 1080 CSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNG 1139
C N DDC HRC NG C+D VN+Y+C C ++GQ C + + C NG
Sbjct: 233 CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT----EDVDECQLQPNACHNG 288
Query: 1140 ANCVDQGNRPVCQCLPGFGGPECEK 1164
C + C C+ G+ G C +
Sbjct: 289 GTCFNTLGGHSCVCVNGWTGESCSQ 313
Score = 181 bits (458), Expect = 6e-45
Identities = 94/260 (36%), Positives = 131/260 (50%), Gaps = 19/260 (7%)
Query: 912 FECQGPPTLAVQAK-CDL---CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
F C PP VQ + C+L C +PC++ G C + P ++ C+CP G++G C+ +D
Sbjct: 756 FHCTCPP--GVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDE 813
Query: 968 CSS-GPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGN 1026
C+ PC G C G F+C+C G+ GP+C + +DC + C NGG C DGVG+
Sbjct: 814 CAGPAPCGPHGICTNLAGS---FSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870
Query: 1027 YTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDD 1086
++C C + G C + VD C NPC C C C PGY G +C ++ D
Sbjct: 871 FSCSCLPGFAGPRCARDVDECLS--NPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPD 927
Query: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQG 1146
C C NG C+D VNS+SCLC GY+G C+ PC C +G C
Sbjct: 928 CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ------HEADPCLSRPCLHGGVCSAAH 981
Query: 1147 NRPVCQCLPGFGGPECEKLL 1166
C CL F GP+C+ L+
Sbjct: 982 PGFRCTCLESFTGPQCQTLV 1001
Score = 179 bits (455), Expect = 1e-44
Identities = 96/252 (38%), Positives = 120/252 (47%), Gaps = 19/252 (7%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Q + D CLS PC + G C + +RC C + G C+ +D CS PC+NGG C Q
Sbjct: 960 QHEADPCLSRPCLHGGVC-SAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC-VQ 1017
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDC----------VDHACANGGVCVDGVGNYTCQCP 1032
G C CP G+ G C + + C ++ C GG CVD ++ C CP
Sbjct: 1018 TGA----YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCP 1073
Query: 1033 LQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRC 1092
G CEQ VD C PCQH C G G CEC+PGY GDNC ++ D+C C
Sbjct: 1074 EGRTGSHCEQEVDPCLAQ--PCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
Query: 1093 QNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE-GTECQNGANCVDQGNRPVC 1151
Q+G C+D V Y C C G G LCEI P P + G C + CVD C
Sbjct: 1132 QHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRC 1191
Query: 1152 QCLPGFGGPECE 1163
C PG+ G CE
Sbjct: 1192 TCPPGYTGLRCE 1203
Score = 178 bits (452), Expect = 3e-44
Identities = 105/323 (32%), Positives = 141/323 (43%), Gaps = 57/323 (17%)
Query: 887 EPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQ---AKCDLCLSSP--CQNQGTCH 941
E + C G + + G + + CQ PP Q D C P C N GTC
Sbjct: 234 EVNVDDCPGHRCLNGGTCVDG-VNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCF 292
Query: 942 NDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPT 1001
N L + C C +G+ G C ++D C++ C +G TCH + A F C+CP G G
Sbjct: 293 NT-LGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV---ASFYCACPMGKTGLL 348
Query: 1002 CGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQ 1059
C ++ D CV + C +C G C CP + G AC+Q VD CS NPC+H +
Sbjct: 349 CHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGR 407
Query: 1060 CVGTPD-----------GPRCE---------------------------CMPGYAGDNCS 1081
CV T GPRCE CM G+ G C
Sbjct: 408 CVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCE 467
Query: 1082 ENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGAN 1141
+ D+C+ C NG C D VN +SC C G+SG C++ C T C+NGA
Sbjct: 468 VDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV------DECASTPCRNGAK 521
Query: 1142 CVDQGNRPVCQCLPGFGGPECEK 1164
CVDQ + C+C GF G C++
Sbjct: 522 CVDQPDGYECRCAEGFEGTLCDR 544
Score = 175 bits (444), Expect = 3e-43
Identities = 90/249 (36%), Positives = 124/249 (49%), Gaps = 26/249 (10%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
+++ D C S PC++ G C D ++ Y C CPSG G +CEV++D C+S PC G C +
Sbjct: 580 ESQVDECRSQPCRHGGKCL-DLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVC--R 635
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
+G + + C C GF GP C V ++C C GG CVDG + C CP
Sbjct: 636 DGINR-YDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCP-------PGS 687
Query: 1043 LVDLCSPDLNPCQHE----AQCVGTPDGPRCECMPGYAGDNCSEN--QDDCRDHRCQNGA 1096
L LC P +PC HE C P G RC C PG++G CS++ +D C C+ G
Sbjct: 688 LPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG 747
Query: 1097 QCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVD-QGNRPVCQCLP 1155
C + + C C G G+ CE+ SPC C++G C G PVC C
Sbjct: 748 TCSSDGMGFHCTCPPGVQGRQCEL-------LSPCTPNPCEHGGRCESAPGQLPVCSCPQ 800
Query: 1156 GFGGPECEK 1164
G+ GP C++
Sbjct: 801 GWQGPRCQQ 809
Score = 174 bits (441), Expect = 6e-43
Identities = 91/238 (38%), Positives = 112/238 (47%), Gaps = 13/238 (5%)
Query: 929 CLS-SPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ-EGED 986
CL SPC N G C P C CP G+ G C++ D C SGPC G C +
Sbjct: 43 CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGT 101
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV-GNYTCQCPLQYEGKACEQLVD 1045
A F+C CP GF GP C + D C+ CA+G C G G + C CP Y+G++C VD
Sbjct: 102 ARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
Query: 1046 LCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN-S 1104
C PC+H C+ TP RC+C GY G C C C+NG C + +
Sbjct: 161 ECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT 219
Query: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Y C C G+ GQ CE+ C G C NG CVD N CQC P + G C
Sbjct: 220 YDCACLPGFEGQNCEV------NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
Score = 168 bits (425), Expect = 4e-41
Identities = 102/303 (33%), Positives = 136/303 (44%), Gaps = 23/303 (7%)
Query: 870 CDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQ---GPPTLAVQAKC 926
C C W + E CAGP + T A F C G +
Sbjct: 796 CSCPQGWQGPRCQQDVDE-----CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
+ C +PC N G+C D + + C+C G+ G C +D C S PC GTC
Sbjct: 851 NDCDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTC---TDHV 905
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
A FTC+CP G+ G C + DC +C NGG CVDGV +++C C Y G C+ D
Sbjct: 906 ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYS 1106
C PC H C G RC C+ + G C D C CQNG +C+ + +Y
Sbjct: 966 CLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCV-QTGAY- 1021
Query: 1107 CLCAEGYSGQLCEIPPHLPAPKSPCE-GTE----CQNGANCVDQGNRPVCQCLPGFGGPE 1161
CLC G+SG+LC+I LP ++ + G CQ G CVD+ + C C G G
Sbjct: 1022 CLCPPGWSGRLCDI-RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH 1080
Query: 1162 CEK 1164
CE+
Sbjct: 1081 CEQ 1083
Score = 162 bits (411), Expect = 2e-39
Identities = 96/310 (30%), Positives = 118/310 (38%), Gaps = 79/310 (25%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C SSPC N G C D + + C CPSG+ G C++ +D C+S PC NG C Q
Sbjct: 471 DECQSSPCVNGGVC-KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG- 528
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
+ C C GFEG C N DDC C +G CVDG+ +++C C Y G CE VD
Sbjct: 529 --YECRCAEGFEGTLCDRNVDDCSPDPCHHGR-CVDGIASFSCACAPGYTGTRCESQVDE 585
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQ------------- 1093
C PC+H +C+ D C C G G NC N DDC + C
Sbjct: 586 CRSQ--PCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDC 643
Query: 1094 ------------------------NGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKS 1129
G C+D N + CLC G LC +PP P
Sbjct: 644 VCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC-LPPSHPCAHE 702
Query: 1130 PC----------------------------------EGTECQNGANCVDQGNRPVCQCLP 1155
PC E C+ G C G C C P
Sbjct: 703 PCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP 762
Query: 1156 GFGGPECEKL 1165
G G +CE L
Sbjct: 763 GVQGRQCELL 772
Score = 133 bits (335), Expect = 1e-30
Identities = 98/329 (29%), Positives = 129/329 (39%), Gaps = 44/329 (13%)
Query: 887 EPGIARCAGPQDMEGKLLLTTPAKKFECQGPP-TLAVQAKC--DLCLSSP-------CQN 936
E + CA G + A+ + C PP TL V + D C P C +
Sbjct: 1120 EDDVDECASQPCQHGGSCIDLVAR-YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLH 1178
Query: 937 QGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTG 996
GTC D + +RC CP GY G CE ++ C SG C T + F C C G
Sbjct: 1179 NGTCV-DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
Query: 997 FEGPTCGVNTDDCVDHACANGGVCVDGVG-----NYTCQCPLQYEGKACEQLVDLCSPDL 1051
F GP C C C +GG C G +TC C + G CE++ C
Sbjct: 1238 FSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRE-- 1295
Query: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNC--------SENQDDCRDHRCQNGAQCMDE-- 1101
C C TP GPRC C PG +G +C + C C +G C
Sbjct: 1296 LQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPL 1355
Query: 1102 VNSYSCLCAEGYSGQLCEIPPHLP----APKSPCEGTECQNG-ANCVDQGNRPVCQCLPG 1156
+ C CA+G++G CE P P P+ P + + G C + N P C G
Sbjct: 1356 APFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGC----G 1411
Query: 1157 FGGPECEKLLSVNFVDRDTYLQFTDLQNW 1185
+ G +C LSV D + Q LQ W
Sbjct: 1412 WDGGDCS--LSVG----DPWRQCEALQCW 1434
Score = 102 bits (253), Expect = 4e-21
Identities = 132/533 (24%), Positives = 185/533 (34%), Gaps = 120/533 (22%)
Query: 1003 GVNTDDCVDHA-CANGGVCVDGVGNYT-CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC 1060
G C+D + CANGG C C CP + G+ C QL D C PC C
Sbjct: 37 GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERC-QLEDPCHS--GPCAGRGVC 93
Query: 1061 ----VGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQC-MDEVNSYSCLCAEGYSG 1115
V C C G+ G +CS D C C +GA+C + + C C GY G
Sbjct: 94 QSSVVAGTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQG 152
Query: 1116 QLCEIPPHLPAPKSPCE-GTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRD 1174
+ C + C G C++G C++ CQC G+ GP CE
Sbjct: 153 RSCR------SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN---------- 196
Query: 1175 TYLQFTDLQNWPRANITLQVSTAEDNGILLYN--------GDNDHIAVELYQGHVRVSYD 1226
P N T +G L Y+ G N + V+ GH ++
Sbjct: 197 ---PAVPCAPSPCRN----GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLN-- 247
Query: 1227 PGSYPSSAIYSAETIN-------DGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTL 1279
+ + T N GQF T ++ N +GG+ TL
Sbjct: 248 ----GGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFN--------TL 295
Query: 1280 NSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGC-----IRNLYINNELQDFTKTQMKPG 1334
+ + V G + S + + FHG + + Y + KT +
Sbjct: 296 GGHSCVCVNGWTGE--SCSQNIDDCATAVCFHGATCHDRVASFYCACPMG---KTGLLCH 350
Query: 1335 VVPGC--EPCRKLYCLHGICQPNATPG-PMCHCEAGWVGLHCDQPADGPCHG-HKCVH-G 1389
+ C PC + IC N G +C C G+ G CDQ D G + C H G
Sbjct: 351 LDDACVSNPCHE----DAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLG 406
Query: 1390 QCVPLDALSYSCQCQDGYSGALC-------------NQAGAL------------------ 1418
+CV S+ CQC GY+G C NQA L
Sbjct: 407 RCVNTQG-SFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTY 465
Query: 1419 ----AEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
+ C+ C++G G C C GFSG C+ + EC P R+
Sbjct: 466 CEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRN 518
Score = 79.3 bits (194), Expect = 3e-14
Identities = 53/174 (30%), Positives = 66/174 (37%), Gaps = 14/174 (8%)
Query: 1331 MKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP-ADGPCHGHKCVHG 1389
+ P +P PC C HGIC +A G C CE GW G C Q A C C G
Sbjct: 688 LPPLCLPPSHPCAHEPCSHGICY-DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
Query: 1390 QCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQASGTKGAHCVCDPGF 1448
D + + C C G G C L PC C H G C+++ + C C G+
Sbjct: 747 GTCSSDGMGFHCTCPPGVQGRQCE----LLSPCTPNPCEHGGRCESAPGQLPVCSCPQGW 802
Query: 1449 SGELCEQE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGL 1501
G C+Q+ EC G H IC C G G C Q +
Sbjct: 803 QGPRCQQDVDECAGPAPCGPH------GICTNLAGSFSCTCHGGYTGPSCDQDI 850
Score = 72.4 bits (176), Expect = 3e-12
Identities = 45/126 (35%), Positives = 55/126 (43%), Gaps = 7/126 (5%)
Query: 1341 PCRKLYCLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKC-VHGQCVPLDALS 1398
PC C HG C+ P+C C GW G C Q D C HG C L A S
Sbjct: 774 PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNL-AGS 832
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-S 1457
+SC C GY+G C+Q C CL+G G C C PGF+G C ++
Sbjct: 833 FSCTCHGGYTGPSCDQD---INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVD 889
Query: 1458 ECRGDP 1463
EC +P
Sbjct: 890 ECLSNP 895
Score = 71.2 bits (173), Expect = 7e-12
Identities = 43/132 (32%), Positives = 60/132 (45%), Gaps = 16/132 (12%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHC----DQPADGPC-HGHKCVHGQCVPL 1394
+ C+ C++G + G C C +G+ G C D+ A PC +G KCV
Sbjct: 471 DECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVD------ 524
Query: 1395 DALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Y C+C +G+ G LC++ + C C HG C G C C PG++G CE
Sbjct: 525 QPDGYECRCAEGFEGTLCDRN---VDDCSPDPCHHGRC-VDGIASFSCACAPGYTGTRCE 580
Query: 1455 -QESECRGDPVR 1465
Q ECR P R
Sbjct: 581 SQVDECRSQPCR 592
Score = 68.6 bits (166), Expect = 5e-11
Identities = 54/175 (30%), Positives = 66/175 (37%), Gaps = 16/175 (9%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALS 1398
+PC C HG G MC C G+ G +C+ D C C HG C+ L A
Sbjct: 1086 DPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVD-ECASQPCQHGGSCIDLVA-R 1143
Query: 1399 YSCQCQDGYSGALC----NQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Y C C G G LC + G G +CLH G C C PG++G CE
Sbjct: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Query: 1455 QE-SECRGDP-----VRDFHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQG 1500
+ +ECR RD Q G C S C+ C Q C G
Sbjct: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHG 1258
Score = 68.2 bits (165), Expect = 6e-11
Identities = 53/165 (32%), Positives = 69/165 (41%), Gaps = 18/165 (10%)
Query: 1340 EPCRKLYCLHGICQPNATPGPM-CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDAL 1397
EPCR HG N TPG C C AG+ G C+ PA PC C +G C L
Sbjct: 166 EPCR-----HGGTCLN-TPGSFRCQCPAGYTGPLCENPAV-PCAPSPCRNGGTCRQSGDL 218
Query: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC-EQE 1456
+Y C C G+ G C + C G +CL+G G +C C P ++G+ C E
Sbjct: 219 TYDCACLPGFEGQNCE---VNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV 275
Query: 1457 SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGL 1501
EC+ P + G T S V C G+ C Q +
Sbjct: 276 DECQLQP----NACHNGGTCFNTLGGHSCV-CVNGWTGESCSQNI 315
Score = 67.0 bits (162), Expect = 1e-10
Identities = 43/138 (31%), Positives = 60/138 (43%), Gaps = 11/138 (7%)
Query: 1347 CLHGICQPNATPGPM----CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQ 1402
CL C P + C C G+ G HC+Q C C +G S+SC
Sbjct: 891 CLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPD-CSPSSCFNGGTCVDGVNSFSCL 949
Query: 1403 CQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE-CRG 1461
C+ GY+GA C A+PC CLHG ++ G C C F+G C+ + C
Sbjct: 950 CRPGYTGAHCQHE---ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSR 1006
Query: 1462 DPVRDFHQ-VQRG-YAIC 1477
P ++ + VQ G Y +C
Sbjct: 1007 QPCQNGGRCVQTGAYCLC 1024
Score = 65.1 bits (157), Expect = 5e-10
Identities = 47/155 (30%), Positives = 57/155 (36%), Gaps = 35/155 (22%)
Query: 1341 PCRKLYCLHGI------CQPNATPGPMCH----------------CEAGWVGLHC----- 1373
PC C GI CQP T GP+C+ C G G C
Sbjct: 628 PCTFGVCRDGINRYDCVCQPGFT-GPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPG 686
Query: 1374 -----DQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCL 1428
P PC C HG C + C C+ G+SG C+Q+ A + C C
Sbjct: 687 SLPPLCLPPSHPCAHEPCSHGICYDAPG-GFRCVCEPGWSGPRCSQSLA-RDACESQPCR 744
Query: 1429 HGHCQASGTKGAHCVCDPGFSGELCEQESECRGDP 1463
G +S G HC C PG G CE S C +P
Sbjct: 745 AGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
Score = 64.3 bits (155), Expect = 9e-10
Identities = 46/165 (27%), Positives = 62/165 (37%), Gaps = 43/165 (26%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS- 1398
+ CR C HG + +C C +G G++C+ D C + C G C D ++
Sbjct: 584 DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNID-DCASNPCTFGVC--RDGINR 640
Query: 1399 YSCQCQDGYSGALCN----------------------------QAGAL-------AEPCR 1423
Y C CQ G++G LCN G+L + PC
Sbjct: 641 YDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCA 700
Query: 1424 GLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ---ESECRGDPVR 1465
C HG C G CVC+PG+SG C Q C P R
Sbjct: 701 HEPCSHGICY-DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCR 744
Score = 63.2 bits (152), Expect = 2e-09
Identities = 48/174 (27%), Positives = 63/174 (36%), Gaps = 18/174 (10%)
Query: 1340 EPCRKLYCL-HGICQPNATPGPM---CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPL 1394
+PC C G+CQ + G C C G+ G C P PC C HG +C
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP--DPCLSSPCAHGARCSVG 137
Query: 1395 DALSYSCQCQDGYSGALCNQAGALAEPCR-GLQCLHGHCQASGTKGAHCVCDPGFSGELC 1453
+ C C GY G C + CR G C HG + C C G++G LC
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSD---VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC 194
Query: 1454 EQES-ECRGDPVRDFHQVQRGYAI---CQTTRPLSWVECR---GSCPGQGCCQG 1500
E + C P R+ ++ + C C CPG C G
Sbjct: 195 ENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNG 248
Score = 62.8 bits (151), Expect = 3e-09
Identities = 38/123 (30%), Positives = 51/123 (41%), Gaps = 10/123 (8%)
Query: 1347 CLHGICQPNATPGPM-----CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
CL G C+ AT C C AG+ G +C+ D C CV+G +SC
Sbjct: 435 CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDID-ECQSSPCVNGGVCKDRVNGFSC 493
Query: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECR 1460
C G+SG+ C + C C +G G C C GF G LC++ +C
Sbjct: 494 TCPSGFSGSTCQLD---VDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS 550
Query: 1461 GDP 1463
DP
Sbjct: 551 PDP 553
Score = 61.6 bits (148), Expect = 6e-09
Identities = 37/107 (34%), Positives = 46/107 (42%), Gaps = 9/107 (8%)
Query: 1352 CQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDA----LSYSCQCQDG 1406
C + G C C AG+ G C Q PC C HG QC P L+++C C
Sbjct: 1222 CLQDPGGGFRCLCHAGFSGPRC-QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQP 1280
Query: 1407 YSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC 1453
+ G C + +A CR LQC G +G C C PG SG C
Sbjct: 1281 FWGPRCER---VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324
Score = 60.1 bits (144), Expect = 2e-08
Identities = 47/171 (27%), Positives = 60/171 (35%), Gaps = 51/171 (29%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADG----PC-HGHKCVH------ 1388
+PC CLHG A PG C C + G C D PC +G +CV
Sbjct: 964 DPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCL 1023
Query: 1389 -----------------------------------GQCVPLDALSYSCQCQDGYSGALCN 1413
GQCV D+ Y C C +G +G+ C
Sbjct: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY-CVCPEGRTGSHCE 1082
Query: 1414 QAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDP 1463
Q +PC C HG G C C PG++G+ CE + EC P
Sbjct: 1083 QE---VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQP 1130
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/188 (24%), Positives = 67/188 (35%), Gaps = 25/188 (13%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADG-PCHGHKCVHGQCVPLDALS 1398
+ C CL+G + C C W G C + D + C +G
Sbjct: 238 DDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGG 297
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE 1458
+SC C +G++G C+Q + C C HG +C C G +G LC +
Sbjct: 298 HSCVCVNGWTGESCSQN---IDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDA 354
Query: 1459 CRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCP----GQGCCQGLRLKRRKFTFECSD 1514
C +P + AIC T C +CP G C Q + ECS
Sbjct: 355 CVSNPCHE-------DAICDTNPVNGRAIC--TCPPGFTGGACDQDVD--------ECSI 397
Query: 1515 GTSFAEEV 1522
G + E +
Sbjct: 398 GANPCEHL 405
Score = 51.2 bits (121), Expect = 8e-06
Identities = 48/163 (29%), Positives = 60/163 (36%), Gaps = 20/163 (12%)
Query: 1326 FTKTQMKPGVVPGCE----PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP- 1380
FT +P P CE CR+L C G+ GP C C G G C P
Sbjct: 1273 FTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPP 1332
Query: 1381 ------CHGHKCVH-GQCVPLD-ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHC 1432
C C+H G C P A + C C G++G C A E +C C
Sbjct: 1333 GASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAAC 1392
Query: 1433 QAS-GTKGAHCVCDP---GFSGELCEQESECRGDPVRDFHQVQ 1471
QA G + C+ G+ G C S GDP R +Q
Sbjct: 1393 QAKRGDQRCDRECNSPGCGWDGGDC---SLSVGDPWRQCEALQ 1432
Score = 42.0 bits (97), Expect = 0.005
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 9/80 (11%)
Query: 1416 GALAEPCR-GLQCLHG-HCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRG 1473
GA A PC G C +G C ++ A C+C PG+ GE C+ E C P G
Sbjct: 37 GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPC-------AG 89
Query: 1474 YAICQTTRPLSWVECRGSCP 1493
+CQ++ CP
Sbjct: 90 RGVCQSSVVAGTARFSCRCP 109
Score = 39.7 bits (91), Expect = 0.023
Identities = 39/134 (29%), Positives = 45/134 (33%), Gaps = 23/134 (17%)
Query: 1333 PGVVPGCE--PCRKLYCLHG-ICQPNA-TPGPMCHCEAGWVGLHCDQPADGP--CHGHKC 1386
PG PG C CLHG C+P P C C GW G C+ PA P +C
Sbjct: 1328 PGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRC 1387
Query: 1387 VHGQCVP------LDALSYSCQCQDGYSGALCN-QAGALAEPCRGLQCLHGHCQASGTKG 1439
C D S C G+ G C+ G C LQC +
Sbjct: 1388 PRAACQAKRGDQRCDRECNSPGC--GWDGGDCSLSVGDPWRQCEALQCWRLFNNSR---- 1441
Query: 1440 AHCVCDPGFSGELC 1453
CDP S C
Sbjct: 1442 ----CDPACSSPAC 1451
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 211 bits (536), Expect = 6e-54
Identities = 95/231 (41%), Positives = 128/231 (55%), Gaps = 12/231 (5%)
Query: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
PC N GTC N + YRC CP GY GR+CE + +C+S PC NGG+CH + F C
Sbjct: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHE---VPSGFECH 372
Query: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
CP+G+ GPTC ++ D+C + CA GG CVD V + C CP Q+ G C+ + C +
Sbjct: 373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANEC--EGK 430
Query: 1053 PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEG 1112
PC + C G C+C+PG+ G NC N +DCR +CQ+G C D VN Y C+C G
Sbjct: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCPRG 489
Query: 1113 YSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
+ G+ CE+ + C + C +G C D + C C GF GP CE
Sbjct: 490 FGGRHCEL------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
Score = 181 bits (460), Expect = 4e-45
Identities = 87/241 (36%), Positives = 124/241 (51%), Gaps = 13/241 (5%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D CL PC+N GTC D ++ +RC CPSG++G C+ + + C PC + G C+ +
Sbjct: 638 DDCLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND- 695
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
F C+C G++G TC C + C+NGG C D + C CP ++G C +
Sbjct: 696 --FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753
Query: 1047 -CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSY 1105
C P NPC + CVG+ C C G+ G C+ N +DC C NG C+D VN +
Sbjct: 754 SCLP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
Query: 1106 SCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
C CA G++G C I C+ + C GA CVD+ N C C PG GP C+++
Sbjct: 812 RCECAPGFAGPDCRINI------DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEV 865
Query: 1166 L 1166
+
Sbjct: 866 I 866
Score = 167 bits (424), Expect = 6e-41
Identities = 92/311 (29%), Positives = 126/311 (40%), Gaps = 60/311 (19%)
Query: 909 AKKFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
A F C P + + DLC SPC+N C+N + Y CACP + G++C V
Sbjct: 517 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVPR 575
Query: 966 DSCSSGPCENGGTCHAQEGEDAP---------------------FTCSCPTGFEGPTCGV 1004
+ C G C C + G P F+C C +GF G C
Sbjct: 576 EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 635
Query: 1005 NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTP 1064
N DDC+ C NGG C+D V + C CP +EG+ C+ + C PD PC +C
Sbjct: 636 NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLV 693
Query: 1065 DGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHL 1124
+ C C G+ G C + C + C NG C D +++ C C G+ G C + +
Sbjct: 694 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753
Query: 1125 PAPKSPC------------------EGTE---------------CQNGANCVDQGNRPVC 1151
+PC +G E C NG CVD N C
Sbjct: 754 SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
Query: 1152 QCLPGFGGPEC 1162
+C PGF GP+C
Sbjct: 814 ECAPGFAGPDC 824
Score = 166 bits (420), Expect = 2e-40
Identities = 92/268 (34%), Positives = 131/268 (48%), Gaps = 32/268 (11%)
Query: 892 RCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCA 951
RC P EG+L T P CL PC ++G C+ D + + CA
Sbjct: 659 RCFCPSGWEGELCDTNPND------------------CLPDPCHSRGRCY-DLVNDFYCA 699
Query: 952 CPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGV-NTDDCV 1010
C G+KG+ C C + C NGGTC+ G+ F C+CP G++G TC V C+
Sbjct: 700 CDDGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDT--FRCACPPGWKGSTCAVAKNSSCL 756
Query: 1011 DHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCE 1070
+ C NGG CV +++C C +EG+ C + C+P PC + CV + RCE
Sbjct: 757 PNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP--LPCYNGGICVDGVNWFRCE 814
Query: 1071 CMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
C PG+AG +C N D+C+ C GA C+DE+N Y C C G +G C+ +
Sbjct: 815 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ---EVIGFGRS 871
Query: 1131 C--EGTECQNGANCVDQGNRPVCQCLPG 1156
C GT +G++ V+ N C+CL G
Sbjct: 872 CWSRGTPFPHGSSWVEDCNS--CRCLDG 897
Score = 162 bits (411), Expect = 2e-39
Identities = 84/260 (32%), Positives = 116/260 (44%), Gaps = 36/260 (13%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C SSPC + G C D + + C CP G+ G CEV +D C PC NG C+ EG+
Sbjct: 500 DECASSPCHSGGLC-EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD- 557
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHAC-----------------ANGGVC-------VD 1022
+ C+CP F G C V + C AC A GVC
Sbjct: 558 --YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ 615
Query: 1023 GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSE 1082
GN++C C + G C + +D C PC++ C+ D RC C G+ G+ C
Sbjct: 616 PGGNFSCICDSGFTGTYCHENIDDCLG--QPCRNGGTCIDEVDAFRCFCPSGWEGELCDT 673
Query: 1083 NQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANC 1142
N +DC C + +C D VN + C C +G+ G+ C + + C+ C NG C
Sbjct: 674 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH------SREFQCDAYTCSNGGTC 727
Query: 1143 VDQGNRPVCQCLPGFGGPEC 1162
D G+ C C PG+ G C
Sbjct: 728 YDSGDTFRCACPPGWKGSTC 747
Score = 154 bits (388), Expect = 8e-37
Identities = 91/290 (31%), Positives = 119/290 (41%), Gaps = 59/290 (20%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTC--------- 979
C S+PC N G+CH P + C CPSG+ G C + +D C+S PC GGTC
Sbjct: 351 CTSNPCANGGSCHEVP-SGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFEC 409
Query: 980 -------------HAQEGEDAP-------------FTCSCPTGFEGPTCGVNTDDCVDHA 1013
A E E P + C C G++G C +N +DC
Sbjct: 410 ICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ- 468
Query: 1014 CANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMP 1073
C +GG C D V Y C CP + G+ CE D C+ +PC C DG C C
Sbjct: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS--SPCHSGGLCEDLADGFHCHCPQ 526
Query: 1074 GYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE- 1132
G++G C + D C C+NGA+C + Y C C + + G+ C +P P P C
Sbjct: 527 GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE-PCPGGACRV 585
Query: 1133 -------------GTE----CQNGANCVDQ-GNRPVCQCLPGFGGPECEK 1164
GT C CV Q G C C GF G C +
Sbjct: 586 IDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 635
Score = 70.9 bits (172), Expect = 9e-12
Identities = 51/169 (30%), Positives = 65/169 (38%), Gaps = 22/169 (13%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQD 1405
C+HG C C+CE W GL CD+ + H C +G C+ + Y C C D
Sbjct: 282 CVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPV 1464
GYSG C +A C C +G G C C G+SG C + EC +P
Sbjct: 338 GYSGRNCEKA---EHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394
Query: 1465 RD----FHQVQRGYAICQTTRPLSWV--ECR---GSCPGQGCCQGLRLK 1504
QV IC P WV C+ C G+ C K
Sbjct: 395 AAGGTCVDQVDGFECIC----PEQWVGATCQLDANECEGKPCLNAFSCK 439
Score = 64.7 bits (156), Expect = 7e-10
Identities = 47/162 (29%), Positives = 58/162 (35%), Gaps = 11/162 (6%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C CL+ N G C C GW G++C + C G +C HG Y C
Sbjct: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVND-CRG-QCQHGGTCKDLVNGYQC 484
Query: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE-CR 1460
C G+ G C + C C G G HC C GFSG LCE + + C
Sbjct: 485 VCPRGFGGRHCELE---RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 541
Query: 1461 GDPVRDFHQVQ--RGYAICQTTRPLSWVEC---RGSCPGQGC 1497
P R+ + G C C R CPG C
Sbjct: 542 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGAC 583
Score = 64.7 bits (156), Expect = 7e-10
Identities = 33/103 (32%), Positives = 42/103 (40%), Gaps = 4/103 (3%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
C C GW G C + C + CV+G S+SC C+DG+ G C
Sbjct: 736 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN---TND 792
Query: 1422 CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
C L C +G G C C PGF+G C EC+ P
Sbjct: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 835
Score = 63.9 bits (154), Expect = 1e-09
Identities = 55/188 (29%), Positives = 70/188 (37%), Gaps = 35/188 (18%)
Query: 1342 CRKLYC------LHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLD 1395
C++ C LHG C PG C C GW G CD+ P CVHG CV
Sbjct: 240 CKEAVCKQGCNLLHGGC---TVPGE-CRCSYGWQGRFCDECVPYP----GCVHGSCVE-- 289
Query: 1396 ALSYSCQCQDGYSGALC----NQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGE 1451
+ C C+ + G LC N G+ PC G C + C C G+SG
Sbjct: 290 --PWQCNCETNWGGLLCDKDLNYCGS-HHPCTN----GGTCINAEPDQYRCTCPDGYSGR 342
Query: 1452 LCEQ-ESECRGDPVRD---FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLK 1504
CE+ E C +P + H+V G+ C S C C C G
Sbjct: 343 NCEKAEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASNPCAAGGTCV 401
Query: 1505 RRKFTFEC 1512
+ FEC
Sbjct: 402 DQVDGFEC 409
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/125 (32%), Positives = 47/125 (37%), Gaps = 6/125 (4%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C C G + G C C WVG C A+ C G C++ Y
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDAN-ECEGKPCLNAFSCKNLIGGY 445
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SE 1458
C C G+ G C+ CRG QC HG G CVC GF G CE E E
Sbjct: 446 YCDCIPGWKGINCH---INVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE 501
Query: 1459 CRGDP 1463
C P
Sbjct: 502 CASSP 506
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/178 (29%), Positives = 68/178 (38%), Gaps = 30/178 (16%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHC----DQPADGPCHGHKCVHGQCVPLDAL 1397
C C +G G CHC +GW G C D+ A PC G CV
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC----AAGGTCVD-QVD 405
Query: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QE 1456
+ C C + + GA C A C G CL+ + G +C C PG+ G C
Sbjct: 406 GFECICPEQWVGATCQLD---ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINV 462
Query: 1457 SECRG---------DPVRDFHQV-QRGYA--ICQTTRPLSWVECRGS-CPGQGCCQGL 1501
++CRG D V + V RG+ C+ R EC S C G C+ L
Sbjct: 463 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD----ECASSPCHSGGLCEDL 516
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/150 (26%), Positives = 56/150 (37%), Gaps = 32/150 (21%)
Query: 1339 CEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKC------------ 1386
CEP C +G N C C + G +C P + PC G C
Sbjct: 540 CEPSP---CRNGARCYNLEGDYYCACPDDFGGKNCSVPRE-PCPGGACRVIDGCGSDAGP 595
Query: 1387 ------------VHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQA 1434
HG+CV ++SC C G++G C++ + C G C +G
Sbjct: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN---IDDCLGQPCRNGGTCI 652
Query: 1435 SGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
C C G+ GELC+ ++C DP
Sbjct: 653 DEVDAFRCFCPSGWEGELCDTNPNDCLPDP 682
Score = 52.0 bits (123), Expect = 4e-06
Identities = 36/109 (33%), Positives = 45/109 (41%), Gaps = 16/109 (14%)
Query: 1362 CHCEAGWVGLHCD-QPAD---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGA 1417
C C +GW G CD P D PCH G+C L + C C DG+ G C+
Sbjct: 660 CFCPSGWEGELCDTNPNDCLPDPCHSR----GRCYDL-VNDFYCACDDGWKGKTCHSREF 714
Query: 1418 LAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELC--EQESECRGDP 1463
C C +G C SG C C PG+ G C + S C +P
Sbjct: 715 ---QCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSCLPNP 759
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/151 (27%), Positives = 60/151 (39%), Gaps = 28/151 (18%)
Query: 1022 DGVGNYTCQ------CPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGY 1075
D G+YTC C + GK C++ V C N G C C G+
Sbjct: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCTVPG-----ECRCSYGW 268
Query: 1076 AGDNCSENQDDCRDHR-CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
G C D+C + C +G+ C V + C C + G LC+ + PC
Sbjct: 269 QGRFC----DECVPYPGCVHGS-C---VEPWQCNCETNWGGLLCDKDLNYCGSHHPCT-- 318
Query: 1135 ECQNGANCVD-QGNRPVCQCLPGFGGPECEK 1164
NG C++ + ++ C C G+ G CEK
Sbjct: 319 ---NGGTCINAEPDQYRCTCPDGYSGRNCEK 346
Score = 40.0 bits (92), Expect = 0.017
Identities = 25/104 (24%), Positives = 33/104 (31%), Gaps = 3/104 (2%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C L C +G + C C G+ G C D C C +G + Y C
Sbjct: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINID-ECQSSPCAYGATCVDEINGYRC 851
Query: 1402 QCQDGYSGALCNQAGALAEPC--RGLQCLHGHCQASGTKGAHCV 1443
C G +G C + C RG HG C+
Sbjct: 852 SCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 211 bits (536), Expect = 6e-54
Identities = 100/242 (41%), Positives = 124/242 (51%), Gaps = 12/242 (4%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C +PC N GTC Y C CP GY G CE +D CS PC N G C GE
Sbjct: 1197 CFFNPCHNSGTCQQLG-RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE--- 1252
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
F C CP+G+ G C N ++C C N G+CVDGV Y C C + G CE V+ C
Sbjct: 1253 FICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ 1312
Query: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCL 1108
NPC + A C G C+C PG+ G C +N D+C C+NGA C D NS+ CL
Sbjct: 1313 S--NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCL 1370
Query: 1109 CAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSV 1168
CA G++G CE+ + C+ C+N A CVD+ N C+C PGF G CE S
Sbjct: 1371 CAAGFTGSHCEL------NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
Query: 1169 NF 1170
F
Sbjct: 1425 GF 1426
Score = 166 bits (419), Expect = 2e-40
Identities = 79/200 (39%), Positives = 110/200 (55%), Gaps = 6/200 (3%)
Query: 920 LAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTC 979
L + D C PC N G C D + + C CPSGY G+ CE +++ CSS PC N G C
Sbjct: 1226 LKCETDIDECSPLPCLNNGVC-KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC 1284
Query: 980 HAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKA 1039
+G A + C+C GF G C ++C + C N VC D VG + C+CP + G
Sbjct: 1285 --VDGV-AGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTR 1341
Query: 1040 CEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM 1099
C + VD C PC++ A C + RC C G+ G +C N ++C+ + C+N A C+
Sbjct: 1342 CGKNVDECLS--QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCV 1399
Query: 1100 DEVNSYSCLCAEGYSGQLCE 1119
DE+NSYSC C G+SG+ CE
Sbjct: 1400 DELNSYSCKCQPGFSGKRCE 1419
Score = 114 bits (286), Expect = 6e-25
Identities = 58/157 (36%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 1008 DCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP 1067
+C + C N G C Y C CPL Y G CE +D CSP PC + C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP--LPCLNNGVCKDLVGEF 1253
Query: 1068 RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAP 1127
CEC GY G C EN ++C C N C+D V Y C C +G+ G CE
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE------TE 1307
Query: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
+ C+ C N A C DQ +C+C PGF G C K
Sbjct: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGK 1344
Score = 73.2 bits (178), Expect = 2e-12
Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 9/95 (9%)
Query: 912 FECQGPPTLAVQAKC----DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
F C+ PP + +C D CLS PC+N TC D +RC C +G+ G CE++++
Sbjct: 1329 FLCKCPPGF-LGTRCGKNVDECLSQPCKNGATC-KDGANSFRCLCAAGFTGSHCELNINE 1386
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
C S PC N TC E ++C C GF G C
Sbjct: 1387 CQSNPCRNQATC---VDELNSYSCKCQPGFSGKRC 1418
Score = 67.0 bits (162), Expect = 1e-10
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 7/127 (5%)
Query: 1342 CRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400
C CL+ GIC + G C C G+VGLHC+ + C + C++ +
Sbjct: 1273 CSSSPCLNKGICV-DGVAGYRCTCVKGFVGLHCETEVN-ECQSNPCLNNAVCEDQVGGFL 1330
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
C+C G+ G C G + C C +G G C+C GF+G CE +EC
Sbjct: 1331 CKCPPGFLGTRC---GKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINEC 1387
Query: 1460 RGDPVRD 1466
+ +P R+
Sbjct: 1388 QSNPCRN 1394
Score = 65.9 bits (159), Expect = 3e-10
Identities = 41/113 (36%), Positives = 52/113 (46%), Gaps = 20/113 (17%)
Query: 972 PCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQC 1031
PC+NGG C P CSCP G+ G C C+ C NGG CV Y C C
Sbjct: 3475 PCQNGGICQR------PNACSCPEGWMGRLC--EEPICI-LPCLNGGRCV---APYQCDC 3522
Query: 1032 PLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQ 1084
P + G C V C +PC + +CV P+ RC C+ + G NCS +
Sbjct: 3523 PPGWTGSRCHTAV--CQ---SPCLNGGKCV-RPN--RCHCLSSWTGHNCSRKR 3567
Score = 64.3 bits (155), Expect = 9e-10
Identities = 41/117 (35%), Positives = 49/117 (41%), Gaps = 19/117 (16%)
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985
C PCQN G C C+CP G+ GR CE + PC NGG C A
Sbjct: 3468 CRAVCRFPCQNGGICQRPNA----CSCPEGWMGRLCEEPICIL---PCLNGGRCVA---- 3516
Query: 986 DAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
P+ C CP G+ G C +T C C NGG C V C C + G C +
Sbjct: 3517 --PYQCDCPPGWTGSRC--HTAVC-QSPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565
Score = 62.4 bits (150), Expect = 3e-09
Identities = 50/176 (28%), Positives = 68/176 (38%), Gaps = 13/176 (7%)
Query: 1350 GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCV-HGQCVPLDALSYSCQCQDGYS 1408
G CQ G +C C G+ GL C+ D C C+ +G C L + C+C GY+
Sbjct: 1206 GTCQQLGR-GYVCLCPLGYTGLKCETDID-ECSPLPCLNNGVCKDLVG-EFICECPSGYT 1262
Query: 1409 GALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD- 1466
G C + C CL+ G G C C GF G CE E +EC+ +P +
Sbjct: 1263 GQRCEEN---INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNN 1319
Query: 1467 -FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFECSDGTSF 1518
+ Q G +C+ C C Q C G K +F C F
Sbjct: 1320 AVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
Score = 48.9 bits (115), Expect = 4e-05
Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 22/113 (19%)
Query: 1337 PGCEPCRKLYCLHG-ICQ-PNATPGPMCHCEAGWVGLHCDQP-ADGPC-HGHKCVHGQCV 1392
P C + C +G ICQ PNA C C GW+G C++P PC +G +CV
Sbjct: 3466 PICRAVCRFPCQNGGICQRPNA-----CSCPEGWMGRLCEEPICILPCLNGGRCV----- 3515
Query: 1393 PLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHG---HCQASGTKGAHC 1442
Y C C G++G+ C+ A + G +C+ HC +S T G +C
Sbjct: 3516 ----APYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWT-GHNC 3563
Score = 45.4 bits (106), Expect = 4e-04
Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 9/106 (8%)
Query: 1313 CIRNLYINNELQDFTKTQMKPGVV-----PGCEPCRKLYCLHGICQPNATPGPMCHCEAG 1367
C+ N +++ F + PG + + C C +G + C C AG
Sbjct: 1316 CLNNAVCEDQVGGFL-CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 1368 WVGLHCDQPADGPCHGHKCVHGQCVPLDAL-SYSCQCQDGYSGALC 1412
+ G HC+ + C + C Q +D L SYSC+CQ G+SG C
Sbjct: 1375 FTGSHCELNIN-ECQSNPC-RNQATCVDELNSYSCKCQPGFSGKRC 1418
Score = 42.7 bits (99), Expect = 0.003
Identities = 25/71 (35%), Positives = 30/71 (42%), Gaps = 15/71 (21%)
Query: 1092 CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVC 1151
CQNG C +C C EG+ G+LCE P + C NG CV C
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPICI---------LPCLNGGRCVAPYQ---C 3520
Query: 1152 QCLPGFGGPEC 1162
C PG+ G C
Sbjct: 3521 DCPPGWTGSRC 3531
Score = 40.4 bits (93), Expect = 0.013
Identities = 47/162 (29%), Positives = 63/162 (38%), Gaps = 34/162 (20%)
Query: 1002 CGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQ 1059
C D+ D C G C G G++ C C Y GK + +
Sbjct: 277 CSYLCDEGKD-CCDRMGSCKCGTHTGHFECICEKGYYGKGLQY----------------E 319
Query: 1060 CVGTPDGP-RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGY--SGQ 1116
C P G + E PG +C D+ +H G+ ++ C+C EGY SGQ
Sbjct: 320 CTACPSGTYKPEGSPG-GISSCIPCPDE--NHTSPPGSTSPED-----CVCREGYRASGQ 371
Query: 1117 LCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV-CQCLPGF 1157
CE+ H PA K P G QN C + N +C PGF
Sbjct: 372 TCEL-VHCPALKPPENGYFIQN--TCNNHFNAACGVRCHPGF 410
Score = 34.7 bits (78), Expect = 0.73
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHG-HCQASGTKGAHCVCDPGFSGELC 1453
+C C +G+ G LC EP L CL+G C A C C PG++G C
Sbjct: 3487 ACSCPEGWMGRLCE------EPICILPCLNGGRCVAP----YQCDCPPGWTGSRC 3531
Score = 34.3 bits (77), Expect = 0.95
Identities = 40/162 (24%), Positives = 51/162 (31%), Gaps = 34/162 (20%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDG 1406
C G +P +PG + C + C P H G P D C C++G
Sbjct: 323 CPSGTYKPEGSPGGISSC------IPC------PDENHTSPPGSTSPED-----CVCREG 365
Query: 1407 Y--SGALCN--QAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGF------------SG 1450
Y SG C AL P G + C C PGF +G
Sbjct: 366 YRASGQTCELVHCPALKPPENGY-FIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG 424
Query: 1451 ELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSC 1492
ES CR Q + G+ C T L C +C
Sbjct: 425 LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVAC 466
Score = 33.1 bits (74), Expect = 2.1
Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 24/128 (18%)
Query: 1342 CRKLYCL--HGI--CQPNAT-PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDA 1396
CR+ + L HGI C P+ T CE + C PA + VH Q D
Sbjct: 3384 CREGFLLQGHGIITCNPDETWTQTSAKCEK----ISCGPPAHVENAIARGVHYQYG--DM 3437
Query: 1397 LSYSCQCQ---DGYSGALCNQAGALAEP--CRGL---QCLHGH-CQASGTKGAHCVCDPG 1447
++YSC +G+ ++C + G P CR + C +G CQ C C G
Sbjct: 3438 ITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNA----CSCPEG 3493
Query: 1448 FSGELCEQ 1455
+ G LCE+
Sbjct: 3494 WMGRLCEE 3501
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 205 bits (522), Expect = 2e-52
Identities = 92/230 (40%), Positives = 124/230 (53%), Gaps = 12/230 (5%)
Query: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
PC N GTC N + YRC CP GY GR+CE + +C+S PC NGG+CH + F C
Sbjct: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHE---VPSGFECH 372
Query: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
CP+G+ GPTC ++ D+C + CA GG CVD V + C CP Q+ G C+ V+ C
Sbjct: 373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR---G 429
Query: 1053 PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEG 1112
CQH C +G +C C G+ G +C +D+C C +G C D + + C C +G
Sbjct: 430 QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 489
Query: 1113 YSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
+SG LCE+ L CE + C+NGA C + C C FGG C
Sbjct: 490 FSGPLCEVDVDL------CEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
Score = 181 bits (460), Expect = 4e-45
Identities = 87/241 (36%), Positives = 124/241 (51%), Gaps = 13/241 (5%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D CL PC+N GTC D ++ +RC CPSG++G C+ + + C PC + G C+ +
Sbjct: 600 DDCLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND- 657
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
F C+C G++G TC C + C+NGG C D + C CP ++G C +
Sbjct: 658 --FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 715
Query: 1047 -CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSY 1105
C P NPC + CVG+ C C G+ G C+ N +DC C NG C+D VN +
Sbjct: 716 SCLP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 773
Query: 1106 SCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
C CA G++G C I C+ + C GA CVD+ N C C PG GP C+++
Sbjct: 774 RCECAPGFAGPDCRINI------DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEV 827
Query: 1166 L 1166
+
Sbjct: 828 I 828
Score = 167 bits (424), Expect = 6e-41
Identities = 92/311 (29%), Positives = 126/311 (40%), Gaps = 60/311 (19%)
Query: 909 AKKFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
A F C P + + DLC SPC+N C+N + Y CACP + G++C V
Sbjct: 479 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVPR 537
Query: 966 DSCSSGPCENGGTCHAQEGEDAP---------------------FTCSCPTGFEGPTCGV 1004
+ C G C C + G P F+C C +GF G C
Sbjct: 538 EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 597
Query: 1005 NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTP 1064
N DDC+ C NGG C+D V + C CP +EG+ C+ + C PD PC +C
Sbjct: 598 NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLV 655
Query: 1065 DGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHL 1124
+ C C G+ G C + C + C NG C D +++ C C G+ G C + +
Sbjct: 656 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 715
Query: 1125 PAPKSPC------------------EGTE---------------CQNGANCVDQGNRPVC 1151
+PC +G E C NG CVD N C
Sbjct: 716 SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 775
Query: 1152 QCLPGFGGPEC 1162
+C PGF GP+C
Sbjct: 776 ECAPGFAGPDC 786
Score = 166 bits (420), Expect = 2e-40
Identities = 92/268 (34%), Positives = 131/268 (48%), Gaps = 32/268 (11%)
Query: 892 RCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCA 951
RC P EG+L T P CL PC ++G C+ D + + CA
Sbjct: 621 RCFCPSGWEGELCDTNPND------------------CLPDPCHSRGRCY-DLVNDFYCA 661
Query: 952 CPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGV-NTDDCV 1010
C G+KG+ C C + C NGGTC+ G+ F C+CP G++G TC V C+
Sbjct: 662 CDDGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDT--FRCACPPGWKGSTCAVAKNSSCL 718
Query: 1011 DHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCE 1070
+ C NGG CV +++C C +EG+ C + C+P PC + CV + RCE
Sbjct: 719 PNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP--LPCYNGGICVDGVNWFRCE 776
Query: 1071 CMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
C PG+AG +C N D+C+ C GA C+DE+N Y C C G +G C+ +
Sbjct: 777 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ---EVIGFGRS 833
Query: 1131 C--EGTECQNGANCVDQGNRPVCQCLPG 1156
C GT +G++ V+ N C+CL G
Sbjct: 834 CWSRGTPFPHGSSWVEDCNS--CRCLDG 859
Score = 77.8 bits (190), Expect = 8e-14
Identities = 53/170 (31%), Positives = 67/170 (39%), Gaps = 26/170 (15%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQD 1405
C+HG C C+CE W GL CD+ + H C +G C+ + Y C C D
Sbjct: 282 CVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPV 1464
GYSG C +A C C +G G C C G+SG C + EC +P
Sbjct: 338 GYSGRNCEKA---EHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394
Query: 1465 RD----FHQVQRGYAICQTTRPLSWV---------ECRGSCPGQGCCQGL 1501
QV IC P WV +CRG C G C+ L
Sbjct: 395 AAGGTCVDQVDGFECIC----PEQWVGATCQLDVNDCRGQCQHGGTCKDL 440
Score = 64.7 bits (156), Expect = 7e-10
Identities = 33/103 (32%), Positives = 42/103 (40%), Gaps = 4/103 (3%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
C C GW G C + C + CV+G S+SC C+DG+ G C
Sbjct: 698 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN---TND 754
Query: 1422 CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
C L C +G G C C PGF+G C EC+ P
Sbjct: 755 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 797
Score = 63.2 bits (152), Expect = 2e-09
Identities = 43/127 (33%), Positives = 49/127 (38%), Gaps = 14/127 (11%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHC----DQPADGPCHGHKCVHGQCVPLDAL 1397
C C +G G CHC +GW G C D+ A PC G CV
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC----AAGGTCVD-QVD 405
Query: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE- 1456
+ C C + + GA C CRG QC HG G CVC GF G CE E
Sbjct: 406 GFECICPEQWVGATCQLD---VNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELER 461
Query: 1457 SECRGDP 1463
EC P
Sbjct: 462 DECASSP 468
Score = 58.5 bits (140), Expect = 5e-08
Identities = 46/164 (28%), Positives = 56/164 (34%), Gaps = 11/164 (6%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C C G + G C C WVG C + C G +C HG Y
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVND-CRG-QCQHGGTCKDLVNGY 444
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE- 1458
C C G+ G C + C C G G HC C GFSG LCE + +
Sbjct: 445 QCVCPRGFGGRHCELE---RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 501
Query: 1459 CRGDPVRDFHQVQ--RGYAICQTTRPLSWVEC---RGSCPGQGC 1497
C P R+ + G C C R CPG C
Sbjct: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGAC 545
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/150 (26%), Positives = 56/150 (37%), Gaps = 32/150 (21%)
Query: 1339 CEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKC------------ 1386
CEP C +G N C C + G +C P + PC G C
Sbjct: 502 CEPSP---CRNGARCYNLEGDYYCACPDDFGGKNCSVPRE-PCPGGACRVIDGCGSDAGP 557
Query: 1387 ------------VHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQA 1434
HG+CV ++SC C G++G C++ + C G C +G
Sbjct: 558 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN---IDDCLGQPCRNGGTCI 614
Query: 1435 SGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
C C G+ GELC+ ++C DP
Sbjct: 615 DEVDAFRCFCPSGWEGELCDTNPNDCLPDP 644
Score = 52.0 bits (123), Expect = 4e-06
Identities = 36/109 (33%), Positives = 45/109 (41%), Gaps = 16/109 (14%)
Query: 1362 CHCEAGWVGLHCD-QPAD---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGA 1417
C C +GW G CD P D PCH G+C L + C C DG+ G C+
Sbjct: 622 CFCPSGWEGELCDTNPNDCLPDPCHSR----GRCYDL-VNDFYCACDDGWKGKTCHSREF 676
Query: 1418 LAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELC--EQESECRGDP 1463
C C +G C SG C C PG+ G C + S C +P
Sbjct: 677 ---QCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSCLPNP 721
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/151 (27%), Positives = 60/151 (39%), Gaps = 28/151 (18%)
Query: 1022 DGVGNYTCQ------CPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGY 1075
D G+YTC C + GK C++ V C N G C C G+
Sbjct: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCTVPG-----ECRCSYGW 268
Query: 1076 AGDNCSENQDDCRDHR-CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
G C D+C + C +G+ C V + C C + G LC+ + PC
Sbjct: 269 QGRFC----DECVPYPGCVHGS-C---VEPWQCNCETNWGGLLCDKDLNYCGSHHPCT-- 318
Query: 1135 ECQNGANCVD-QGNRPVCQCLPGFGGPECEK 1164
NG C++ + ++ C C G+ G CEK
Sbjct: 319 ---NGGTCINAEPDQYRCTCPDGYSGRNCEK 346
Score = 40.0 bits (92), Expect = 0.017
Identities = 25/104 (24%), Positives = 33/104 (31%), Gaps = 3/104 (2%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C L C +G + C C G+ G C D C C +G + Y C
Sbjct: 755 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINID-ECQSSPCAYGATCVDEINGYRC 813
Query: 1402 QCQDGYSGALCNQAGALAEPC--RGLQCLHGHCQASGTKGAHCV 1443
C G +G C + C RG HG C+
Sbjct: 814 SCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 857
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 204 bits (520), Expect = 4e-52
Identities = 184/651 (28%), Positives = 242/651 (37%), Gaps = 129/651 (19%)
Query: 894 AGPQDMEGKLLLTTPAKKFECQGPPTL---AVQAKCDLCLSSP--CQNQGTCHNDPLEVY 948
A P G L T P + +C PP A + + C P C +CHN L +
Sbjct: 162 ANPCVNGGVCLATYP--QIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNT-LGSF 218
Query: 949 RCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPF-TCSCPTGFEGPTCGVNTD 1007
+C CP G +G CE+ C C NGGTC +D+ F C CP GF GP C VN D
Sbjct: 219 QCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPD 278
Query: 1008 DCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNP-CQHEAQCVGTPDG 1066
+CV H C NGG C DG+ YTC CP + G C + VD C P C++ C +
Sbjct: 279 NCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGS 338
Query: 1067 PRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC------------------- 1107
C C+ G+ G +C EN DDC C G+ C+D V S+SC
Sbjct: 339 FHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLS 398
Query: 1108 --------------------LCAEGYSGQLC--EIPPHLPAPK--SPCE-GTECQN---- 1138
LC GYSG C ++ L A + SPCE G C N
Sbjct: 399 QPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGS 458
Query: 1139 ----------GANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRA 1188
G+ C N C P G C LL+ F L
Sbjct: 459 FNCLCPPGYTGSRCEADHNE--CLSQPCHPGSTCLDLLAT----------FHCLCPPGLE 506
Query: 1189 NITLQVSTAEDNGILLYNGDNDHIAVELYQ-------GHVRVSYDPGSYPSSAIYSAETI 1241
+V T E N + H + +Q R D SS +
Sbjct: 507 GQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQC 566
Query: 1242 ND--GQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAF 1299
D G FH L F+ P + L+ P VG +D+ A F
Sbjct: 567 QDQPGAFHCKCLPGFE----------GPRCQTEVDE--CLSDPCP--VGASCLDLPGAFF 612
Query: 1300 RLWQILNGTGFHG-------CIRNLYINNELQDFTKTQMK---PGVVPGCEPCR-KLYCL 1348
L +GF G C NL ++ K + P PGC P C
Sbjct: 613 CLCP----SGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCH 668
Query: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGY 1407
HG CQ ++ C C+ GW G C+ G C C HG C P + Y+C C GY
Sbjct: 669 HGHCQRSS-----CVCDVGWTGPECEAELGG-CISAPCAHGGTCYPQPS-GYNCTCPTGY 721
Query: 1408 SGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE 1458
+G C++ C CL+G G +C C P +G C+ ++
Sbjct: 722 TGPTCSEE---MTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTD 769
Score = 201 bits (512), Expect = 3e-51
Identities = 92/245 (37%), Positives = 129/245 (52%), Gaps = 9/245 (3%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
+A+ C+S+PC + GTC+ P Y C CP+GY G C + +C SGPC NGG+C+
Sbjct: 689 EAELGGCISAPCAHGGTCYPQP-SGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPS 747
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
G + C+CP GP C +TD CV C NGG CV+ G ++C C + ++G CE
Sbjct: 748 PGG---YYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEG 804
Query: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
+ D +PC++ A C +P GPRC C GY G +C D C C + C+
Sbjct: 805 KLRPSCAD-SPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTG 863
Query: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTE----CQNGANCVDQGNRPVCQCLPGFG 1158
S+ CLC +G++G LC +P + +G + C NG CVD G C C PGF
Sbjct: 864 PSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQ 923
Query: 1159 GPECE 1163
G C+
Sbjct: 924 GSLCQ 928
Score = 174 bits (441), Expect = 6e-43
Identities = 89/247 (36%), Positives = 116/247 (46%), Gaps = 24/247 (9%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C SPC+N+ TC + P + RC CP+GY G C+ +D C+ PC C Q G
Sbjct: 810 CADSPCRNRATCQDSP-QGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHC-LQTGPS-- 865
Query: 989 FTCSCPTGFEGPTCGVNTDDC----------VDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
F C C G+ GP C + C V C NGG+CVD +Y C CP ++G
Sbjct: 866 FHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGS 925
Query: 1039 ACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQC 1098
C+ V+ C + PCQ+ A C+ P G C+C PGY G NCS+ D C+ C N C
Sbjct: 926 LCQDHVNPC--ESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTC 983
Query: 1099 MDEVNSYSCLCAEGYSGQLCE--IPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPG 1156
+ + C C G+ G CE + L P P C + AN CQCLPG
Sbjct: 984 TPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAF------YCQCLPG 1037
Query: 1157 FGGPECE 1163
G CE
Sbjct: 1038 HTGQWCE 1044
Score = 165 bits (418), Expect = 3e-40
Identities = 94/288 (32%), Positives = 120/288 (41%), Gaps = 19/288 (6%)
Query: 888 PGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLS-------SPCQNQGTC 940
PG C P G+L CQ Q CL +P ++ TC
Sbjct: 608 PGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTC 667
Query: 941 HNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGP 1000
H+ + C C G+ G +CE L C S PC +GGTC+ Q + + C+CPTG+ GP
Sbjct: 668 HHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQP---SGYNCTCPTGYTGP 724
Query: 1001 TCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC 1060
TC C C NGG C G Y C CP + G C+ D C PC + C
Sbjct: 725 TCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSA--PCFNGGTC 782
Query: 1061 VGTPDGPRCECMPGYAGDNCSEN-QDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCE 1119
V P C C G+ G C + C D C+N A C D CLC GY+G C+
Sbjct: 783 VNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 842
Query: 1120 IPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLS 1167
L A K C ++C+ G C CL G+ GP C LS
Sbjct: 843 TLMDLCAQKP------CPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLS 884
Score = 160 bits (406), Expect = 7e-39
Identities = 86/251 (34%), Positives = 120/251 (47%), Gaps = 16/251 (6%)
Query: 923 QAKC-DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHA 981
QAK D C S C +G CH +C+C G+ G C++ D CS+ PC NGG C A
Sbjct: 115 QAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLA 173
Query: 982 QEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA--CANGGVCVDGVGNYTCQCPLQYEGKA 1039
+ C CP GFEG C + ++C C G C + +G++ C CP+ EG
Sbjct: 174 TYPQ---IQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPR 230
Query: 1040 CEQLVDLCSPDLNPCQHEAQCVGTPDGPR----CECMPGYAGDNCSENQDDCRDHRCQNG 1095
CE C P C + C P+ C C PG+ G +C N D+C H+CQNG
Sbjct: 231 CELRAGPCPP--RGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNG 288
Query: 1096 AQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLP 1155
C D +++Y+CLC E ++G C + P C+NG C + C C+
Sbjct: 289 GTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGP---PHCRNGGTCQNSAGSFHCVCVS 345
Query: 1156 GFGGPECEKLL 1166
G+GG CE+ L
Sbjct: 346 GWGGTSCEENL 356
Score = 156 bits (394), Expect = 2e-37
Identities = 85/271 (31%), Positives = 115/271 (42%), Gaps = 35/271 (12%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS--------------- 967
Q + D CLS PC +C + P + C CPSG+ G+ CEV L +
Sbjct: 587 QTEVDECLSDPCPVGASCLDLP-GAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKD 645
Query: 968 -----CSSG-----PCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANG 1017
C G P E+ TCH G +C C G+ GP C C+ CA+G
Sbjct: 646 KANCLCPDGSPGCAPPEDNCTCH--HGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHG 703
Query: 1018 GVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAG 1077
G C Y C CP Y G C + + C PC + C +P G C C P + G
Sbjct: 704 GTCYPQPSGYNCTCPTGYTGPTCSEEMTACHS--GPCLNGGSCNPSPGGYYCTCPPSHTG 761
Query: 1078 DNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQ 1137
C + D C C NG C++ ++SCLCA G+ G CE + C + C+
Sbjct: 762 PQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE-----GKLRPSCADSPCR 816
Query: 1138 NGANCVDQGNRPVCQCLPGFGGPECEKLLSV 1168
N A C D P C C G+ G C+ L+ +
Sbjct: 817 NRATCQDSPQGPRCLCPTGYTGGSCQTLMDL 847
Score = 150 bits (378), Expect = 1e-35
Identities = 91/266 (34%), Positives = 112/266 (42%), Gaps = 24/266 (9%)
Query: 914 CQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS 970
C PP Q + C S PCQN TC P Y C C GY G++C LD+C S
Sbjct: 916 CHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQP-SGYLCQCAPGYDGQNCSKELDACQS 974
Query: 971 GPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGV--CVDGVGNYT 1028
PC N GTC + G F C+CP GF G C + D+C+D C G C +
Sbjct: 975 QPCHNHGTCTPKPGG---FHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFY 1031
Query: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC---VGTPDGPRCECMPGYAGDNCSENQD 1085
CQC + G+ CE +D C PC H C G+P G C C G+ G CS
Sbjct: 1032 CQCLPGHTGQWCEVEIDPCHSQ--PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAP 1089
Query: 1086 DCRDHRCQNGAQCMDEVN---SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANC 1142
C H C +G C+ C C GY G C P PAPK + C +C
Sbjct: 1090 SCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP---PAPKGCGPPSPCLYNGSC 1146
Query: 1143 VDQ----GNRPVCQCLPGFGGPECEK 1164
+ G C C GP C+K
Sbjct: 1147 SETTGLGGPGFRCSCPHSSPGPRCQK 1172
Score = 148 bits (373), Expect = 5e-35
Identities = 95/327 (29%), Positives = 115/327 (35%), Gaps = 77/327 (23%)
Query: 912 FECQGPPTLAVQAKCDL----CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
F C PP L Q C++ C S+PC N CH D L ++C C G+ G CE +D
Sbjct: 497 FHCLCPPGLEGQL-CEVETNECASAPCLNHADCH-DLLNGFQCICLPGFSGTRCEEDIDE 554
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDD------------------- 1008
C S PC NGG C Q G F C C GFEGP C D+
Sbjct: 555 CRSSPCANGGQCQDQPGA---FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAF 611
Query: 1009 -----------------CVDHACANGGVCVDGVGNYTCQCPLQYEGKA------------ 1039
C + C +C D C CP G A
Sbjct: 612 FCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGH 671
Query: 1040 CEQLVDLCS-----PDLN---------PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQD 1085
C++ +C P+ PC H C P G C C GY G CSE
Sbjct: 672 CQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMT 731
Query: 1086 DCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQ 1145
C C NG C Y C C ++G C+ C C NG CV++
Sbjct: 732 ACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDY------CVSAPCFNGGTCVNR 785
Query: 1146 GNRPVCQCLPGFGGPECEKLLSVNFVD 1172
C C GF GP CE L + D
Sbjct: 786 PGTFSCLCAMGFQGPRCEGKLRPSCAD 812
Score = 115 bits (289), Expect = 2e-25
Identities = 98/310 (31%), Positives = 118/310 (38%), Gaps = 67/310 (21%)
Query: 912 FECQGPPT---LAVQAKCDLCLSSPCQNQGT--CHNDPLEVYRCACPSGYKGRDCEVSLD 966
F C PP L + D CL PC GT CH+ Y C C G+ G+ CEV +D
Sbjct: 990 FHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFY-CQCLPGHTGQWCEVEID 1048
Query: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVG- 1025
C S PC +GGTC A G F C CP GFEGPTC C H C +GG+C+
Sbjct: 1049 PCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKP 1108
Query: 1026 --NYTCQCPLQYEGKAC--EQLVDLCSPDLNPCQHEAQC-----VGTP----------DG 1066
C C Y G C C P +PC + C +G P G
Sbjct: 1109 GFPPRCACLSGYGGPDCLTPPAPKGCGPP-SPCLYNGSCSETTGLGGPGFRCSCPHSSPG 1167
Query: 1067 PRCE---------------CMPG-------YAGDNCSENQDD----CRDH-RCQ---NGA 1096
PRC+ C G + G +CS D C H RC
Sbjct: 1168 PRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDG 1227
Query: 1097 QCMDEVNSYSCLCAEGYSGQLCEIPPH-LPAPKSPC----EGTECQNGANCVDQGNRPVC 1151
QC + +S CL + G CE PP PA C C+ G N + G
Sbjct: 1228 QCHPQCDSEECL----FDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECG-WDGG 1282
Query: 1152 QCLPGFGGPE 1161
C P G PE
Sbjct: 1283 DCRPEDGDPE 1292
Score = 85.9 bits (211), Expect = 3e-16
Identities = 52/176 (29%), Positives = 77/176 (43%), Gaps = 26/176 (14%)
Query: 1014 CANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC-------VGTPD 1065
CANGG C+ +G TCQC + G+ C Q D C + CQ+ C +G P
Sbjct: 35 CANGGTCLSLSLGQGTCQCAPGFLGETC-QFPDPCQ-NAQLCQNGGSCQALLPAPLGLPS 92
Query: 1066 GPR-------CECMPGYAGDNCSEN-QDDCRDHRCQNGAQCMDEVNSY-SCLCAEGYSGQ 1116
P C C+PG+ G+ C +D C C +C + + C C G++G+
Sbjct: 93 SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGE 152
Query: 1117 LCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVD 1172
C++ + C C NG C+ + C C PGF G CE+ ++ F D
Sbjct: 153 QCQL-------RDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQD 201
Score = 72.8 bits (177), Expect = 2e-12
Identities = 46/151 (30%), Positives = 59/151 (39%), Gaps = 15/151 (9%)
Query: 1350 GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSG 1409
G+C + P CHC G+ G C + PC C +G Y CQC GY G
Sbjct: 905 GLCVDSG-PSYFCHCPPGFQGSLCQDHVN-PCESRPCQNGATCMAQPSGYLCQCAPGYDG 962
Query: 1410 ALCNQA--GALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
C++ ++PC HG C G HC C PGF G CE + EC P
Sbjct: 963 QNCSKELDACQSQPCHN----HGTCTPK-PGGFHCACPPGFVGLRCEGDVDECLDQPCH- 1016
Query: 1467 FHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1497
G A C + + +C GQ C
Sbjct: 1017 ----PTGTAACHSLANAFYCQCLPGHTGQWC 1043
Score = 64.7 bits (156), Expect = 7e-10
Identities = 55/196 (28%), Positives = 77/196 (39%), Gaps = 42/196 (21%)
Query: 1340 EPCRKLYCLHGICQPNATP---GPMCHCEAGWVGLHCDQPAD---------GPC-HGHKC 1386
+PC HG Q + P +C C+ G+ G C Q D PC HG C
Sbjct: 399 QPC------HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSC 452
Query: 1387 VHGQCVPLDALSYSCQCQDGYSGALC--NQAGALAEPCR-GLQCLHGHCQASGTKGAHCV 1443
++ S++C C GY+G+ C + L++PC G CL HC+
Sbjct: 453 LNTPG------SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCL------DLLATFHCL 500
Query: 1444 CDPGFSGELCEQE-SECRGDPV---RDFHQVQRGYAICQTTRPLSWVECR---GSCPGQG 1496
C PG G+LCE E +EC P D H + G+ C S C C
Sbjct: 501 CPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQ-CICLPGFSGTRCEEDIDECRSSP 559
Query: 1497 CCQGLRLKRRKFTFEC 1512
C G + + + F C
Sbjct: 560 CANGGQCQDQPGAFHC 575
Score = 63.9 bits (154), Expect = 1e-09
Identities = 48/153 (31%), Positives = 61/153 (39%), Gaps = 29/153 (18%)
Query: 1340 EPCRKLYCLHGICQPNATPGPM-CHCEAGWVGLHC----DQPADGPCH--GHKCVHGQCV 1392
+PC HG C P PG C C G+VGL C D+ D PCH G H
Sbjct: 975 QPCHN----HGTCTPK--PGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSL-- 1026
Query: 1393 PLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGH-CQASGTK--GAHCVCDPGFS 1449
A ++ CQC G++G C +PC C HG C+A+ G C C GF
Sbjct: 1027 ---ANAFYCQCLPGHTGQWCEVE---IDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFE 1080
Query: 1450 GELCEQESECRGDPVRDFHQVQRGYAICQTTRP 1482
G C + P FH G + +P
Sbjct: 1081 GPTCSHRA-----PSCGFHHCHHGGLCLPSPKP 1108
Score = 62.0 bits (149), Expect = 4e-09
Identities = 41/135 (30%), Positives = 53/135 (39%), Gaps = 25/135 (18%)
Query: 1341 PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADG----PCHGHKCVHGQCVPLDA 1396
PC C +G G +C C G+ G +C + D PCH HG C P
Sbjct: 933 PCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHN----HGTCTPKPG 988
Query: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAH-------CVCDPGFS 1449
+ C C G+ G C G + E CL C +GT H C C PG +
Sbjct: 989 -GFHCACPPGFVGLRCE--GDVDE------CLDQPCHPTGTAACHSLANAFYCQCLPGHT 1039
Query: 1450 GELCEQESE-CRGDP 1463
G+ CE E + C P
Sbjct: 1040 GQWCEVEIDPCHSQP 1054
Score = 61.2 bits (147), Expect = 7e-09
Identities = 43/153 (28%), Positives = 61/153 (39%), Gaps = 13/153 (8%)
Query: 1357 TPGPMCHCEAGWVGLHCDQPADGPCHGHKCV-HGQCVPLDALSYSCQCQDGYSGALCNQA 1415
TP +C C G+ G C + PC C G+C + C C G++G C
Sbjct: 98 TPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQ-- 155
Query: 1416 GALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDP-----VRDFHQ 1469
L + C C++G + C C PGF G CE++ +EC DP H
Sbjct: 156 --LRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHN 213
Query: 1470 VQRGY-AICQTTRPLSWVECR-GSCPGQGCCQG 1500
+ +C + E R G CP +GC G
Sbjct: 214 TLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNG 246
Score = 58.2 bits (139), Expect = 6e-08
Identities = 52/179 (29%), Positives = 64/179 (35%), Gaps = 23/179 (12%)
Query: 1337 PGCEPCRKLYCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQC 1391
P CE + C C+ AT GP C C G+ G C D C C
Sbjct: 800 PRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMD-LCAQKPCPRNSH 858
Query: 1392 VPLDALSYSCQCQDGYSGALCN------QAGALAEPCRGLQCLH--GHCQASGTKGAHCV 1443
S+ C C G++G LCN Q AL++ H G C SG C
Sbjct: 859 CLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPS-YFCH 917
Query: 1444 CDPGFSGELCEQE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGL 1501
C PGF G LC+ + C P Q G A C +C GQ C + L
Sbjct: 918 CPPGFQGSLCQDHVNPCESRP------CQNG-ATCMAQPSGYLCQCAPGYDGQNCSKEL 969
Score = 57.0 bits (136), Expect = 1e-07
Identities = 43/129 (33%), Positives = 54/129 (41%), Gaps = 22/129 (17%)
Query: 1347 CLHGICQPNATPGPM-----CHCEAGWVGLHCD----QPADGPCHGHKCVHGQCVPLDAL 1397
CL C P +T + C C G G C+ + A PC H H D L
Sbjct: 479 CLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCH------DLL 532
Query: 1398 S-YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA-HCVCDPGFSGELCEQ 1455
+ + C C G+SG C + + CR C +G Q GA HC C PGF G C+
Sbjct: 533 NGFQCICLPGFSGTRCEED---IDECRSSPCANGG-QCQDQPGAFHCKCLPGFEGPRCQT 588
Query: 1456 E-SECRGDP 1463
E EC DP
Sbjct: 589 EVDECLSDP 597
Score = 55.8 bits (133), Expect = 3e-07
Identities = 50/182 (27%), Positives = 64/182 (35%), Gaps = 27/182 (14%)
Query: 1333 PGVV-PGCEP----CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD-----GPCH 1382
PG + P CE C C +G + C C W G C + D GP H
Sbjct: 266 PGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPH 325
Query: 1383 GHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHC 1442
C +G A S+ C C G+ G C + + C C G C
Sbjct: 326 ---CRNGGTCQNSAGSFHCVCVSGWGGTSCEEN---LDDCIAATCAPGSTCIDRVGSFSC 379
Query: 1443 VCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVE---CRGSCPGQGCCQ 1499
+C PG +G LC E C P G A C +T PL+ C+ G C Q
Sbjct: 380 LCPPGRTGLLCHLEDMCLSQPC-------HGDAQC-STNPLTGSTLCLCQPGYSGPTCHQ 431
Query: 1500 GL 1501
L
Sbjct: 432 DL 433
Score = 53.1 bits (126), Expect = 2e-06
Identities = 46/174 (26%), Positives = 60/174 (34%), Gaps = 31/174 (17%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH--GQC-----V 1392
EPC G C + C C G++G C P PC + G C
Sbjct: 33 EPCAN----GGTCLSLSLGQGTCQCAPGFLGETCQFP--DPCQNAQLCQNGGSCQALLPA 86
Query: 1393 PLD--------ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCL-HGHCQASGTKGAHCV 1443
PL S+ C C G++G C L +PC C G C + C
Sbjct: 87 PLGLPSSPSPLTPSFLCTCLPGFTGERCQ--AKLEDPCPPSFCSKRGRCHIQASGRPQCS 144
Query: 1444 CDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1497
C PG++GE C+ C +P V G +C T P C G C
Sbjct: 145 CMPGWTGEQCQLRDFCSANPC-----VNGG--VCLATYPQIQCHCPPGFEGHAC 191
Score = 50.4 bits (119), Expect = 1e-05
Identities = 63/251 (25%), Positives = 80/251 (31%), Gaps = 61/251 (24%)
Query: 1340 EPCRKLYCL-HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS 1398
+PC +C G C A+ P C C GW G C Q D C + CV+G
Sbjct: 120 DPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC-QLRDF-CSANPCVNGGVCLATYPQ 177
Query: 1399 YSCQCQDGYSGALC---------------------NQAGAL----------------AEP 1421
C C G+ G C N G+ A P
Sbjct: 178 IQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGP 237
Query: 1422 CRGLQCLHGH-CQASGTKGAH---CVCDPGFSGELCE-QESECRGDPVRDFHQVQRGYAI 1476
C C +G CQ K + C+C PGF G CE C ++ Q G
Sbjct: 238 CPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDT 297
Query: 1477 CQTTRPLSWV-----ECRGSCPGQG---CCQGLRLKRRKFTFECS-----DGTSFAEEVE 1523
P +W E C QG C G + +F C GTS E ++
Sbjct: 298 YTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLD 357
Query: 1524 KPTKCGCALCA 1534
C A CA
Sbjct: 358 ---DCIAATCA 365
Score = 50.4 bits (119), Expect = 1e-05
Identities = 39/126 (30%), Positives = 49/126 (38%), Gaps = 11/126 (8%)
Query: 1340 EPCRKLYCLHG-ICQPNATP--GPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLD 1395
+PC C HG C+ A G +CHC G+ G C A C H C H G C+P
Sbjct: 1048 DPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPS-CGFHHCHHGGLCLPSP 1106
Query: 1396 ALSY--SCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQAS---GTKGAHCVCDPGFS 1449
+ C C GY G C A CL+ G C + G G C C
Sbjct: 1107 KPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSP 1166
Query: 1450 GELCEQ 1455
G C++
Sbjct: 1167 GPRCQK 1172
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 201 bits (512), Expect = 3e-51
Identities = 148/563 (26%), Positives = 232/563 (41%), Gaps = 110/563 (19%)
Query: 926 CDL----CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHA 981
CDL C S PC+N+ TC N+ + Y C CP Y G +CE+ +D C S PC NG TC
Sbjct: 183 CDLEVDECASDPCKNEATCLNE-IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQD 241
Query: 982 QEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQ-YEGKAC 1040
G + C C GF G C +NTD+C C +GG+CVDG Y+C C + G C
Sbjct: 242 ALGA---YFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298
Query: 1041 EQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMD 1100
E L+ LC PC + A C + D C C PGY G C + ++C + CQ+ +C++
Sbjct: 299 ETLMPLCWS--KPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVE 356
Query: 1101 --------------------EVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA 1140
E + Y C+C G++G CE + C CQNG
Sbjct: 357 LSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE------EDVNECSSNPCQNGG 410
Query: 1141 NCVDQGNRPVCQC------LPGFGGPECEKLL---------------------------- 1166
C + C C +GG +C +L
Sbjct: 411 TCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCL 470
Query: 1167 -----SVNFVDRDTYLQFT-DLQNWPRA----------NITLQVSTAEDNGILLYNGDND 1210
+ + + T L F D W ++ NI L+ T + +LL+ + D
Sbjct: 471 CPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRD 530
Query: 1211 -HIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMT 1269
+ +EL G++ +S + ++ + +DG++H VE++ F + V L++ S
Sbjct: 531 VFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVI-FAEAVTLTLIDDSCKE 589
Query: 1270 MDNFGKHYTLNSEAPL------YVGGMPVDVNS---AAFRLWQILNGTGFHGCIRNLYI- 1319
L S+ + ++GG+PV + S A + + + F GC++++ I
Sbjct: 590 KCIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKID 649
Query: 1320 -NNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCD--QP 1376
N+ + + V GC RK +C CQ C W+ CD +P
Sbjct: 650 WNHITLENISSGSSLNVKAGC--VRKDWCESQPCQSRG------RCINLWLSYQCDCHRP 701
Query: 1377 ADGPCHGHKCVHGQCVPLDALSY 1399
+GP + V G+ D+ Y
Sbjct: 702 YEGPNCLREYVAGRFGQDDSTGY 724
Score = 194 bits (492), Expect = 7e-49
Identities = 95/243 (39%), Positives = 124/243 (51%), Gaps = 15/243 (6%)
Query: 927 DLCLSSPCQNQGTCHNDPLE-VYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985
D C S+PCQ TC N P E + C CP GY G CE ++ SC C++GG CH +
Sbjct: 72 DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICH----Q 127
Query: 986 DAPF-TCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
D + C CP G+ G C ++ D+C C NG VC DG+ Y+C C Y+G+ C+ V
Sbjct: 128 DPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS 1104
D C+ D PC++EA C+ C C Y+G NC D+C C NGA C D + +
Sbjct: 188 DECASD--PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGA 245
Query: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCL-PGFGGPECE 1163
Y C CA G+ G CE+ C C +G CVD NR C C GF G CE
Sbjct: 246 YFCDCAPGFLGDHCEL------NTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299
Query: 1164 KLL 1166
L+
Sbjct: 300 TLM 302
Score = 170 bits (431), Expect = 9e-42
Identities = 87/237 (36%), Positives = 113/237 (47%), Gaps = 12/237 (5%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKG--RDCEVSLDSCSSGPCENGGTCHAQEGED 986
CLS+ CQN TC D + C+C +DC+ D C S PC+ TC GE
Sbjct: 34 CLSNSCQNNSTC-KDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGER 92
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
+ F C CP G+ G C C ++C +GG+C C CP Y G+ CE D
Sbjct: 93 S-FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDE 151
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYS 1106
C+ +PCQ+ A C DG C C+PGY G +C D+C C+N A C++E+ Y+
Sbjct: 152 CAS--SPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYT 209
Query: 1107 CLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
C+C YSG CE+ C C NGA C D C C PGF G CE
Sbjct: 210 CICPHNYSGVNCEL------EIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Score = 148 bits (373), Expect = 5e-35
Identities = 66/199 (33%), Positives = 100/199 (50%), Gaps = 10/199 (5%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
++C S+PC + G C D Y C+CP G+ G+ CE+++D C S PC +G
Sbjct: 1141 NVCNSNPCLHGGNCE-DIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNC----SDRV 1195
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQL--- 1043
A + C+C G+ G C V+ D+C H CANG C+ Y+C C + GK C Q
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 1044 VDLCSPDLN--PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDE 1101
+C + C + C +C C PG+ G+ C ++ D+C C NG C D
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDL 1315
Query: 1102 VNSYSCLCAEGYSGQLCEI 1120
+N + CLC ++G+ CE+
Sbjct: 1316 LNKFQCLCDVAFAGERCEV 1334
Score = 130 bits (328), Expect = 7e-30
Identities = 68/209 (32%), Positives = 90/209 (43%), Gaps = 11/209 (5%)
Query: 957 KGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACAN 1016
K C + C S C+N TC +D +CS C D C + C
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCK-DFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQG 81
Query: 1017 GGVCVDGVG--NYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPG 1074
CV+ G ++ C+CP Y G CE + C N CQH C P P C C G
Sbjct: 82 SATCVNTPGERSFLCKCPPGYSGTICETTIGSCGK--NSCQHGGICHQDPIYPVCICPAG 139
Query: 1075 YAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
YAG C + D+C CQNGA C D ++ YSC C GY G+ C++ C
Sbjct: 140 YAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDL------EVDECASD 193
Query: 1135 ECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
C+N A C+++ R C C + G CE
Sbjct: 194 PCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Score = 129 bits (325), Expect = 2e-29
Identities = 64/158 (40%), Positives = 79/158 (50%), Gaps = 6/158 (3%)
Query: 1009 CVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPR 1068
C + C +GG C D +Y C CPL + GK CE +D C NPC H C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFS--NPCIH-GNCSDRVAAYH 1199
Query: 1069 CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPK 1128
C C PGY G NC + D+C+ H+C NGA C+ N YSCLC ++G+ C LP+
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCR-QSRLPSTV 1258
Query: 1129 SPCEGTE--CQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
E T C NG NC + C C PGF G CEK
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEK 1296
Score = 120 bits (300), Expect = 1e-26
Identities = 106/411 (25%), Positives = 156/411 (37%), Gaps = 72/411 (17%)
Query: 1074 GYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEG 1133
G AGDN C+ + C NG C + +SC C SG+ CE C
Sbjct: 884 GCAGDN------SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-------EVQWCGF 930
Query: 1134 TECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPR--ANIT 1191
+ C +GA QC P G EC + + F + + F N R NIT
Sbjct: 931 SPCPHGA-----------QCQPVLQGFEC--IANAVFNGQSGQILFRSNGNITRELTNIT 977
Query: 1192 LQVSTAEDNGILLY-NGDNDHIAVELYQGHVRVSYDPG-SYPSSAIYSAETINDGQFHTV 1249
T + N I+L+ + + + + + + G S+ ++ S +++NDG +H V
Sbjct: 978 FGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEV 1037
Query: 1250 ELVAFDQMVNLS-----IDGGSPMTMDNF--GKHYTLNSEAPLYVGGMPVDVNSAAFRLW 1302
L D + S +D +P G L +YVG +D
Sbjct: 1038 TLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRAID--------- 1088
Query: 1303 QILNGTGFHGCIRNL---------------YINNELQDFTKTQMKPGVVPGC---EPCRK 1344
N G GC+ + +IN ++ VV GC C
Sbjct: 1089 ---NIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLNVCNS 1145
Query: 1345 LYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQ 1404
CLHG + C C GW G HC+ D C + C+HG C A +Y C C+
Sbjct: 1146 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNID-ECFSNPCIHGNCSDRVA-AYHCTCE 1203
Query: 1405 DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ 1455
GY+G C + C+ QC +G S T G C+C F+G+ C Q
Sbjct: 1204 PGYTGVNCE---VDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ 1251
Score = 68.2 bits (165), Expect = 6e-11
Identities = 52/187 (27%), Positives = 70/187 (37%), Gaps = 21/187 (11%)
Query: 1347 CLHGICQPNAT----PGP---MCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
C CQ +AT PG +C C G+ G C+ G C + C HG D +
Sbjct: 74 CFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTI-GSCGKNSCQHGGICHQDPIYP 132
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SE 1458
C C GY+G C + C C +G G G C C PG+ G C+ E E
Sbjct: 133 VCICPAGYAGRFCEIDH---DECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDE 189
Query: 1459 CRGDPVRD----FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFE 1511
C DP ++ +++ R IC S V C C Q C G + +
Sbjct: 190 CASDPCKNEATCLNEIGRYTCIC--PHNYSGVNCELEIDECWSQPCLNGATCQDALGAYF 247
Query: 1512 CSDGTSF 1518
C F
Sbjct: 248 CDCAPGF 254
Score = 59.3 bits (142), Expect = 3e-08
Identities = 76/358 (21%), Positives = 132/358 (36%), Gaps = 61/358 (17%)
Query: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC-EKLLSVNFVDRDT--YLQFT-DLQ 1183
K CE CQ+ C++ C C + GP C + ++ F D+ Y+ FT D
Sbjct: 673 KDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDES 732
Query: 1184 NWPRANITLQVSTAEDNGILLY--NGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETI 1241
++++ V T + +G+LL N +I V L +G + + + S + +
Sbjct: 733 YGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAML----TPNSPKLVVKFVL 788
Query: 1242 NDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFG----KHYTLNSEAPLYVGGMPVDVNSA 1297
NDG H + L + L + N G + + +Y+GG+P +
Sbjct: 789 NDGNVHLISLKIKPYKIELY------QSSQNLGFISASTWKIEKGDVIYIGGLPDKQETE 842
Query: 1298 AFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNAT 1357
LNG F GCI+++ +NN+ +F NA+
Sbjct: 843 -------LNGGFFKGCIQDVRLNNQNLEFFPNPTN----------------------NAS 873
Query: 1358 PGP-MCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAG 1416
P + + G G D C + C +G +SC C SG C +
Sbjct: 874 LNPVLVNVTQGCAG-------DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-- 924
Query: 1417 ALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGY 1474
+ C C HG +G C+ + F+G+ + G+ R+ + G+
Sbjct: 925 --VQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQILFRSNGNITRELTNITFGF 980
Score = 58.9 bits (141), Expect = 4e-08
Identities = 36/125 (28%), Positives = 46/125 (36%), Gaps = 5/125 (4%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C C +G + G C C G+ G HCD D C C + + Y
Sbjct: 150 DECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD-ECASDPCKNEATCLNEIGRY 208
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QESE 1458
+C C YSG C + C CL+G C C PGF G+ CE E
Sbjct: 209 TCICPHNYSGVNCELE---IDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDE 265
Query: 1459 CRGDP 1463
C P
Sbjct: 266 CASQP 270
Score = 56.2 bits (134), Expect = 2e-07
Identities = 50/188 (26%), Positives = 73/188 (38%), Gaps = 66/188 (35%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHC----DQPADGPC-HGHKCVHGQ---- 1390
+ C CL+G +A C C G++G HC D+ A PC HG CV G+
Sbjct: 226 DECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYS 285
Query: 1391 ------------CVPLDAL-----------------SYSCQCQDGYSGALC----NQAGA 1417
C L L +Y+C C GY+GA C N+ +
Sbjct: 286 CNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNS 345
Query: 1418 LAEPCR------------------GLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SE 1458
PC+ GL + +ASG C+C PGF+G CE++ +E
Sbjct: 346 --NPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYV---CICQPGFTGIHCEEDVNE 400
Query: 1459 CRGDPVRD 1466
C +P ++
Sbjct: 401 CSSNPCQN 408
Score = 52.0 bits (123), Expect = 4e-06
Identities = 25/63 (39%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 1007 DDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDG 1066
+ C + C NGGVC +++C CP GKACE+ V C +PC H AQC G
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCG--FSPCPHGAQCQPVLQG 945
Query: 1067 PRC 1069
C
Sbjct: 946 FEC 948
Score = 50.4 bits (119), Expect = 1e-05
Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 16/107 (14%)
Query: 1359 GPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQC------QDGYSGALC 1412
G +C C+ G+ G+HC++ + C + C +G +Y+C C + Y G C
Sbjct: 380 GYVCICQPGFTGIHCEEDVN-ECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDC 438
Query: 1413 NQAGALAEPCRGLQCLHG-----HCQASGTKGAHCVCDPGFSGELCE 1454
+ + C QCL+ H Q G G C+C G++G LCE
Sbjct: 439 SD---ILLGCTHQQCLNNGTCIPHFQ-DGQHGFSCLCPSGYTGSLCE 481
Score = 47.4 bits (111), Expect = 1e-04
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 4/74 (5%)
Query: 966 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVG 1025
+SC S PC NGG CH++ + F+CSCP G C C C +G C +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDD---FSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQPVLQ 944
Query: 1026 NYTCQCPLQYEGKA 1039
+ C + G++
Sbjct: 945 GFECIANAVFNGQS 958
Score = 45.1 bits (105), Expect = 5e-04
Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTC 979
C S+PC N G CH+ + + C+CP+ G+ CE + C PC +G C
Sbjct: 891 CKSNPCHNGGVCHS-RWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQC 939
Score = 37.7 bits (86), Expect = 0.086
Identities = 17/39 (43%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
D C S PC N G C D L ++C C + G CEV L
Sbjct: 1299 DECASDPCVNGGLCQ-DLLNKFQCLCDVAFAGERCEVDL 1336
Score = 34.7 bits (78), Expect = 0.73
Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 9/87 (10%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHC------EAGWVGLHCDQPADGPCHGHKCVHGQCVPL- 1394
C C +G N CHC + G C G H +G C+P
Sbjct: 401 CSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHF 460
Query: 1395 --DALSYSCQCQDGYSGALCNQAGALA 1419
+SC C GY+G+LC A L+
Sbjct: 461 QDGQHGFSCLCPSGYTGSLCEIATTLS 487
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 200 bits (509), Expect = 8e-51
Identities = 94/268 (35%), Positives = 129/268 (48%), Gaps = 44/268 (16%)
Query: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
PC N GTC N + Y+C+CP GY G +CE++ +C S PC N G+C + F C
Sbjct: 305 PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC---KETSLGFECE 361
Query: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPD-- 1050
C G+ GPTC N DDC + C++GG C D V + C CP Q+ GK C+ + C
Sbjct: 362 CSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPC 421
Query: 1051 ---------------------------------LNPCQHEAQCVGTPDGPRCECMPGYAG 1077
L CQ++A C +G RC C PGYAG
Sbjct: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAG 481
Query: 1078 DNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQ 1137
D+C + D+C + C NG C +E+N + CLC G+SG LC++ CE CQ
Sbjct: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY------CEPNPCQ 535
Query: 1138 NGANCVDQGNRPVCQCLPGFGGPECEKL 1165
NGA C ++ + C+C + G C L
Sbjct: 536 NGAQCYNRASDYFCKCPEDYEGKNCSHL 563
Score = 182 bits (463), Expect = 2e-45
Identities = 88/238 (36%), Positives = 121/238 (50%), Gaps = 13/238 (5%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C S+PC+N GTC D + Y+C C G++G CE +++ CS PC NGGTC +
Sbjct: 633 CESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVND--- 688
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL-C 1047
F C C G++G TC C + C NGG C D + C CP +EG C + C
Sbjct: 689 FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSC 748
Query: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
P NPC + CV + C C G+ G C++N +DC H C N C+D N Y C
Sbjct: 749 LP--NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRC 806
Query: 1108 LCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
CA G++G C I + C+ + C GA CVD+ N C C PG G +C+++
Sbjct: 807 ECAPGFAGPDCRININ------ECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
Score = 176 bits (447), Expect = 1e-43
Identities = 90/231 (38%), Positives = 121/231 (52%), Gaps = 16/231 (6%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C +PC N GTC D + + C C +G+KG+ C C C NGGTC+ EG+
Sbjct: 671 CSQNPCHNGGTCR-DLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY-DEGD--A 726
Query: 989 FTCSCPTGFEGPTCGV-NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLC 1047
F C CP G+EG TC + C+ + C NGG CV ++TC C +EG C Q + C
Sbjct: 727 FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDC 786
Query: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
SP +PC + CV + RCEC PG+AG +C N ++C+ C GA C+DE+N Y C
Sbjct: 787 SP--HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844
Query: 1108 LCAEGYSGQLCEIPPHLPAPKSPC--EGTECQNGANCVDQGNRPVCQCLPG 1156
+C G+SG C+ PC G+ +GA D N CQCL G
Sbjct: 845 VCPPGHSGAKCQ-----EVSGRPCITMGSVIPDGAKWDDDCN--TCQCLNG 888
Score = 176 bits (446), Expect = 2e-43
Identities = 93/280 (33%), Positives = 122/280 (43%), Gaps = 36/280 (12%)
Query: 911 KFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
+F+C P + Q D C +PCQN C+N + Y C CP Y+G++C D
Sbjct: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD-YFCKCPEDYEGKNCSHLKDH 566
Query: 968 CSSGPCENGGTCH-AQEGEDAP------------------------FTCSCPTGFEGPTC 1002
C + PCE +C A D P FTC C GF G C
Sbjct: 567 CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
Query: 1003 GVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVG 1062
N +DC + C NGG C+DGV +Y C C +EG CE ++ CS NPC + C
Sbjct: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQ--NPCHNGGTCRD 684
Query: 1063 TPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPP 1122
+ C+C G+ G C C + C NG C DE +++ C+C G+ G C I
Sbjct: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNI-- 742
Query: 1123 HLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
A S C C NG CV G C C G+ GP C
Sbjct: 743 ---ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
Score = 141 bits (355), Expect = 6e-33
Identities = 95/310 (30%), Positives = 125/310 (40%), Gaps = 77/310 (24%)
Query: 866 NPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAK 925
N YCDC K G+K G + ++
Sbjct: 687 NDFYCDC---------KNGWK-----------------------------GKTCHSRDSQ 708
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLD-SCSSGPCENGGTCHAQEG 984
CD + C N GTC+ D + ++C CP G++G C ++ + SC PC NGGTC G
Sbjct: 709 CD---EATCNNGGTCY-DEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTC-VVNG 763
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
E FTC C G+EGP C NT+DC H C N G CVDG Y C+C + G C +
Sbjct: 764 ES--FTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRINI 821
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN------------------QDD 1086
+ C +PC A CV +G RC C PG++G C E DD
Sbjct: 822 NECQS--SPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDD 879
Query: 1087 CRDHRCQNGAQCMDEV--NSYSCLCAEGY----SGQLCEIPPHLPAPKSPCEGTECQNGA 1140
C +C NG +V CL +G+ SGQ C +P C C
Sbjct: 880 CNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSC-----IPILDDQCFVHPCTGVG 934
Query: 1141 NCVDQGNRPV 1150
C +PV
Sbjct: 935 ECRSSSLQPV 944
Score = 138 bits (348), Expect = 4e-32
Identities = 73/216 (33%), Positives = 97/216 (44%), Gaps = 20/216 (9%)
Query: 950 CACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC 1009
C C G++G C D C P G C+ P+ C C T + G C + + C
Sbjct: 251 CRCQYGWQGLYC----DKCIPHPGCVHGICNE------PWQCLCETNWGGQLCDKDLNYC 300
Query: 1010 VDH-ACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP 1067
H C NGG C + G Y C CP Y G CE C D PC + C T G
Sbjct: 301 GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSD--PCHNRGSCKETSLGF 358
Query: 1068 RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAP 1127
CEC PG+ G CS N DDC + C +G C D VN + C+C ++G+ C++
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL------D 412
Query: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
+ CE C N +C + C CLPG+ G C+
Sbjct: 413 ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/148 (33%), Positives = 64/148 (43%), Gaps = 25/148 (16%)
Query: 1324 QDFTKTQMKPGVVPGCEP--CRK-LYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP 1380
Q+ KT M+ + P C CR+ HG C+ PG C C+ GW GL+CD+ P
Sbjct: 214 QNGNKTCMEGWMGPECNRAICRQGCSPKHGSCK---LPGD-CRCQYGWQGLYCDKCIPHP 269
Query: 1381 CHGHKCVHGQCVPLDALSYSCQCQDGYSGALC----NQAGALAEPCRGLQCLHGHCQASG 1436
CVHG C + C C+ + G LC N G +PC G C +G
Sbjct: 270 ----GCVHGICNE----PWQCLCETNWGGQLCDKDLNYCGT-HQPCLN----GGTCSNTG 316
Query: 1437 TKGAHCVCDPGFSGELCE-QESECRGDP 1463
C C G+SG CE E C DP
Sbjct: 317 PDKYQCSCPEGYSGPNCEIAEHACLSDP 344
Score = 60.5 bits (145), Expect = 1e-08
Identities = 39/145 (26%), Positives = 59/145 (40%), Gaps = 10/145 (6%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C C HG + G C C W G C A+ C CV+ + SY
Sbjct: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDAN-ECEAKPCVNAKSCKNLIASY 434
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SE 1458
C C G+ G C+ C G QC + G C+C PG++G+ CE++ E
Sbjct: 435 YCDCLPGWMGQNCD---ININDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490
Query: 1459 CRGDPVRD----FHQVQRGYAICQT 1479
C +P + +++ R +C T
Sbjct: 491 CASNPCLNGGHCQNEINRFQCLCPT 515
Score = 59.7 bits (143), Expect = 2e-08
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 4/103 (3%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
C C GW G C+ + C + C +G ++ S++C C++G+ G +C Q
Sbjct: 729 CMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQN---TND 785
Query: 1422 CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
C C + G C C PGF+G C +EC+ P
Sbjct: 786 CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP 828
Score = 58.9 bits (141), Expect = 4e-08
Identities = 43/135 (31%), Positives = 52/135 (38%), Gaps = 13/135 (9%)
Query: 1331 MKPGVVPG--CEPCRKLYCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHG 1383
M PG G C R CL C T C C+ GW G C Q + C
Sbjct: 730 MCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND-CSP 788
Query: 1384 HKCVH-GQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHC 1442
H C + G CV D Y C+C G++G C C+ C G G C
Sbjct: 789 HPCYNSGTCVDGDNW-YRCECAPGFAGPDCR---ININECQSSPCAFGATCVDEINGYRC 844
Query: 1443 VCDPGFSGELCEQES 1457
VC PG SG C++ S
Sbjct: 845 VCPPGHSGAKCQEVS 859
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/166 (24%), Positives = 64/166 (38%), Gaps = 15/166 (9%)
Query: 1347 CLHGICQPNATPGP-MCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
CL+G N P C C G+ G +C+ A+ C C + +L + C+C
Sbjct: 306 CLNGGTCSNTGPDKYQCSCPEGYSGPNCEI-AEHACLSDPCHNRGSCKETSLGFECECSP 364
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPV 1464
G++G C+ + C C HG G CVC P ++G+ C+ + +EC P
Sbjct: 365 GWTGPTCS---TNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPC 421
Query: 1465 RDFHQVQRGYAICQTTRPLSWV---------ECRGSCPGQGCCQGL 1501
+ + A W+ +C G C C+ L
Sbjct: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDL 467
Score = 57.0 bits (136), Expect = 1e-07
Identities = 38/127 (29%), Positives = 55/127 (43%), Gaps = 8/127 (6%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C C++ N C C GW+G +CD + C G C L Y C
Sbjct: 416 CEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD-CLGQCQNDASCRDL-VNGYRC 473
Query: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHG-HCQASGTKGAHCVCDPGFSGELCEQESE-C 1459
C GY+G C + + C CL+G HCQ + C+C GFSG LC+ + + C
Sbjct: 474 ICPPGYAGDHCERD---IDECASNPCLNGGHCQNEINR-FQCLCPTGFSGNLCQLDIDYC 529
Query: 1460 RGDPVRD 1466
+P ++
Sbjct: 530 EPNPCQN 536
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/112 (26%), Positives = 46/112 (41%), Gaps = 5/112 (4%)
Query: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYS 1408
HG C+ + C C G+ G +C + + C + C +G SY C C DG+
Sbjct: 602 HGKCKSQSGGKFTCDCNKGFTGTYCHENIND-CESNPCRNGGTCIDGVNSYKCICSDGWE 660
Query: 1409 GALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC-EQESEC 1459
GA C C C +G +C C G+ G+ C ++S+C
Sbjct: 661 GAYCE---TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQC 709
Score = 51.6 bits (122), Expect = 6e-06
Identities = 42/152 (27%), Positives = 58/152 (38%), Gaps = 32/152 (21%)
Query: 1022 DGVGNYTCQ------CPLQYEGKACEQLV--DLCSPDLNPCQHEAQCVGTPDGPRCECMP 1073
D G+Y C C + G C + + CSP C+ C C
Sbjct: 205 DFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDC---------RCQY 255
Query: 1074 GYAGDNCSENQDDCRDHR-CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE 1132
G+ G C D C H C +G C + + CLC + GQLC+ + P
Sbjct: 256 GWQGLYC----DKCIPHPGCVHGI-CNEP---WQCLCETNWGGQLCDKDLNYCGTHQP-- 305
Query: 1133 GTECQNGANCVDQG-NRPVCQCLPGFGGPECE 1163
C NG C + G ++ C C G+ GP CE
Sbjct: 306 ---CLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334
Score = 48.1 bits (113), Expect = 6e-05
Identities = 52/233 (22%), Positives = 78/233 (33%), Gaps = 46/233 (19%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C CL+G N C C G+ G C D C + C +G A Y
Sbjct: 489 DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY-CEPNPCQNGAQCYNRASDY 547
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQC----------------------------LHGH 1431
C+C + Y G C+ L + CR C HG
Sbjct: 548 FCKCPEDYEGKNCSH---LKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGK 604
Query: 1432 CQASGTKGAHCVCDPGFSGELC-EQESECRGDPVRD----FHQVQRGYAICQTTRPLSWV 1486
C++ C C+ GF+G C E ++C +P R+ V IC ++
Sbjct: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664
Query: 1487 E------CRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALC 1533
E + C G C+ L F +C +G + ++C A C
Sbjct: 665 ETNINDCSQNPCHNGGTCRDL---VNDFYCDCKNGWKGKTCHSRDSQCDEATC 714
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 184 bits (467), Expect = 6e-46
Identities = 93/242 (38%), Positives = 112/242 (46%), Gaps = 18/242 (7%)
Query: 927 DLCLSSPCQNQGTC----HNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
D C PCQN +C + C C GY G C+ +D C PC NG TC +
Sbjct: 351 DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISS 410
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC-VDGVGNYTCQCPLQYEGKACE 1041
+ FTC CP G+ G C D C C N G C VDGV ++TC C + G C
Sbjct: 411 L---SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCA 466
Query: 1042 QLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDE 1101
QL+D C+ L+PC H C +C C PGY G C E ++C C N A C D
Sbjct: 467 QLIDFCA--LSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDL 523
Query: 1102 VNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPE 1161
VN Y C+C Y G CE+ K PC C NGA C G C C PGF G E
Sbjct: 524 VNGYECVCLAEYKGTHCEL------YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEE 577
Query: 1162 CE 1163
C+
Sbjct: 578 CD 579
Score = 176 bits (447), Expect = 1e-43
Identities = 88/241 (36%), Positives = 123/241 (51%), Gaps = 13/241 (5%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
Q+K D C+ PC+N TC + L + C CP GY G CE +D C+S PC+N GTC+
Sbjct: 390 QSKIDYCILDPCRNGATCISS-LSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV- 447
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
+ FTC+C GF GPTC D C CA+G C +Y C C Y G CE+
Sbjct: 448 --DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEE 504
Query: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
+ C PC + A C +G C C+ Y G +C +D C + C NGA C +
Sbjct: 505 EYNECLSA--PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDG 562
Query: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
+ +C+CA G++G+ C+I + C+ C +G +C+DQ N C C G+ G C
Sbjct: 563 LNGTCICAPGFTGEECDIDIN------ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
Query: 1163 E 1163
E
Sbjct: 617 E 617
Score = 113 bits (283), Expect = 1e-24
Identities = 60/173 (34%), Positives = 77/173 (44%), Gaps = 16/173 (9%)
Query: 1001 TCGVNTDDCVDHACANGGVCVD--GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEA 1058
TC D C+ G C ++C C QY G CE+ D C PCQ+ A
Sbjct: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DACQR--KPCQNNA 362
Query: 1059 QCVGT---PDGPR--CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGY 1113
C+ DG C C+PGY G+ C D C C+NGA C+ ++ ++C C EGY
Sbjct: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY 422
Query: 1114 SGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
G CE PC + CQN C G C C PGF GP C +L+
Sbjct: 423 FGSACE------EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
Score = 109 bits (272), Expect = 2e-23
Identities = 61/197 (30%), Positives = 86/197 (43%), Gaps = 16/197 (8%)
Query: 973 CENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV-----GNY 1027
C G C + E A F+C+C + G C D C C N C+D N+
Sbjct: 319 CSGKGKCTTKPSE-ATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNF 376
Query: 1028 TCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDC 1087
TC C Y G+ C+ +D C L+PC++ A C+ + G C+C GY G C E D C
Sbjct: 377 TCVCLPGYTGELCQSKIDYCI--LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
Query: 1088 RDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGN 1147
CQN C + ++C C+ G++G C C + C +G C G
Sbjct: 435 ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDF------CALSPCAHGT-CRSVGT 487
Query: 1148 RPVCQCLPGFGGPECEK 1164
C C PG+ G CE+
Sbjct: 488 SYKCLCDPGYHGLYCEE 504
Score = 78.6 bits (192), Expect = 4e-14
Identities = 42/124 (33%), Positives = 61/124 (49%), Gaps = 11/124 (8%)
Query: 1346 YCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400
YC+ C+ AT G C C G+ G C++ D PC C + +D + ++
Sbjct: 395 YCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD-PCASSPCQNNGTCYVDGVHFT 453
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
C C G++G C Q L + C C HG C++ GT C+CDPG+ G CE+E +EC
Sbjct: 454 CNCSPGFTGPTCAQ---LIDFCALSPCAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYNEC 509
Query: 1460 RGDP 1463
P
Sbjct: 510 LSAP 513
Score = 67.8 bits (164), Expect = 8e-11
Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 8/124 (6%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C C HG C+ T C C+ G+ GL+C++ + C C++ Y C
Sbjct: 472 CALSPCAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYN-ECLSAPCLNAATCRDLVNGYEC 529
Query: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELCEQE-SEC 1459
C Y G C +PC + CL+G C + G G C+C PGF+GE C+ + +EC
Sbjct: 530 VCLAEYKGTHCE---LYKDPCANVSCLNGATCDSDGLNGT-CICAPGFTGEECDIDINEC 585
Query: 1460 RGDP 1463
+P
Sbjct: 586 DSNP 589
Score = 66.6 bits (161), Expect = 2e-10
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 24/120 (20%)
Query: 894 AGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEV------ 947
AGP+ L PA GP C + PC+N G C + P
Sbjct: 26 AGPRG--SSLANPVPAAPLSAPGP-----------CAAQPCRNGGVCTSRPEPDPQHPAP 72
Query: 948 -----YRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
Y C CP+G G +C++ D C+S PC +G + + C C G+EGP C
Sbjct: 73 AGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 64.3 bits (155), Expect = 9e-10
Identities = 27/79 (34%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C + C N TC +D L C C G+ G +C++ ++ C S PC +GG+C Q
Sbjct: 545 DPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG- 602
Query: 987 APFTCSCPTGFEGPTCGVN 1005
+ C CP G+ G C ++
Sbjct: 603 --YNCHCPHGWVGANCEIH 619
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/94 (34%), Positives = 41/94 (43%), Gaps = 18/94 (19%)
Query: 1377 ADGPCHGHKCVHGQC------------VPLDALSYSCQCQDGYSGALCNQAGALAEPCRG 1424
A GPC C +G P YSC C G SGA C +A+PC
Sbjct: 44 APGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQ---LVADPCAS 100
Query: 1425 LQCLHGHCQASGTK---GAHCVCDPGFSGELCEQ 1455
C HG+C +S + G C+C+ G+ G CEQ
Sbjct: 101 NPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 57.4 bits (137), Expect = 1e-07
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 968 CSSGPCENGGTCHAQEGED----AP-----FTCSCPTGFEGPTCGVNTDDCVDHACANGG 1018
C++ PC NGG C ++ D AP ++C+CP G G C + D C + C +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 1019 VCVDGVGN---YTCQCPLQYEGKACEQ 1042
+ Y C C YEG CEQ
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 55.1 bits (131), Expect = 5e-07
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 17/89 (19%)
Query: 1009 CVDHACANGGVCVD------------GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQH 1056
C C NGGVC G Y+C CP G C+ + D C+ NPC H
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS--NPCHH 105
Query: 1057 ---EAQCVGTPDGPRCECMPGYAGDNCSE 1082
+ + DG C C GY G NC +
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 55.1 bits (131), Expect = 5e-07
Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
C CL+ + G C C A + G HC+ D PC C++G D L+ +C
Sbjct: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKD-PCANVSCLNGATCDSDGLNGTC 567
Query: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
C G++G C+ C C HG G +C C G+ G CE
Sbjct: 568 ICAPGFTGEECDID---INECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 53.9 bits (128), Expect = 1e-06
Identities = 28/100 (28%), Positives = 42/100 (42%), Gaps = 14/100 (14%)
Query: 1080 CSENQDDCRDHRCQNGAQCMDEVN--SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQ 1137
C + D C +C + + ++SC C E Y G CE C+ CQ
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-------EYDACQRKPCQ 359
Query: 1138 NGANCVD-----QGNRPVCQCLPGFGGPECEKLLSVNFVD 1172
N A+C+D G+ C CLPG+ G C+ + +D
Sbjct: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD 399
Score = 52.8 bits (125), Expect = 3e-06
Identities = 32/90 (35%), Positives = 38/90 (42%), Gaps = 19/90 (21%)
Query: 1340 EPCRKLYCLHGICQ-----------PNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH 1388
+PCR G+C P PG C C AG G +C AD PC + C H
Sbjct: 51 QPCRN----GGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHH 105
Query: 1389 GQCVPLDALS---YSCQCQDGYSGALCNQA 1415
G C + S Y C C +GY G C QA
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Score = 51.6 bits (122), Expect = 6e-06
Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 15/140 (10%)
Query: 1336 VPGCEPCRKLYCL-HGICQPNATPGPM-CHCEAGWVGLHC---DQPADGPCHGHKCVHGQ 1390
VPG L C G C + C CE +VG C D PC +
Sbjct: 308 VPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA 367
Query: 1391 CVPLDALSYSCQCQDGYSGALCNQA--GALAEPCR-GLQCLHGHCQASGTKGAHCVCDPG 1447
D +++C C GY+G LC + +PCR G C+ S G C C G
Sbjct: 368 NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCI------SSLSGFTCQCPEG 421
Query: 1448 FSGELCEQESE-CRGDPVRD 1466
+ G CE++ + C P ++
Sbjct: 422 YFGSACEEKVDPCASSPCQN 441
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/92 (28%), Positives = 36/92 (39%), Gaps = 15/92 (16%)
Query: 1087 CRDHRCQNGAQCMDEVN------------SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
C C+NG C YSC C G SG C++ P +PC
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
Query: 1135 ECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
C + ++ G +C C G+ GP CE+ L
Sbjct: 107 NCSSSSSSSSDGY--LCICNEGYEGPNCEQAL 136
Score = 44.3 bits (103), Expect = 0.001
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 1340 EPCRKLYCLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS 1398
+PC + CL+G C + G C C G+ G CD + C + C HG
Sbjct: 545 DPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDIN-ECDSNPCHHGGSCLDQPNG 602
Query: 1399 YSCQCQDGYSGALCN-----QAGALAE 1420
Y+C C G+ GA C ++G +AE
Sbjct: 603 YNCHCPHGWVGANCEIHLQWKSGHMAE 629
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Query: 925 KCDL----CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
+CD+ C S+PC + G+C + P Y C CP G+ G +CE+ L
Sbjct: 577 ECDIDINECDSNPCHHGGSCLDQP-NGYNCHCPHGWVGANCEIHL 620
Score = 35.0 bits (79), Expect = 0.56
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 4/48 (8%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPL---EVYRCACPSGYKGRDCEVSLDS 967
Q D C S+PC + G C + + Y C C GY+G +CE +L S
Sbjct: 92 QLVADPCASNPCHH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 184 bits (466), Expect = 7e-46
Identities = 91/236 (38%), Positives = 114/236 (48%), Gaps = 13/236 (5%)
Query: 932 SPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTC 991
SPC+N TC N Y C C GY G DCE+ L C S PC NGG+C QE + C
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDG---YHC 348
Query: 992 SCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLVDLCSP 1049
CP G+ G C +T C D C NGG C + NY C+CP + G CE+ VD C+
Sbjct: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
Query: 1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLC 1109
NPC + QC+ C C PG+ G C + DC + C +G C D N C C
Sbjct: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
Query: 1110 AEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRP--VCQCLPGFGGPECE 1163
G+SG+ CE+ + A C + C N A C + VC C GF G CE
Sbjct: 467 PAGFSGRRCEVRTSIDA----CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 155 bits (393), Expect = 2e-37
Identities = 82/247 (33%), Positives = 116/247 (46%), Gaps = 17/247 (6%)
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS-GPCENGGTCHAQEG 984
C+ C+ GTC ++C C G+ G C+ L+ C+ PC+NG TC + G
Sbjct: 250 CNECIPHNGCRHGTCSTP----WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC-SNSG 304
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
+ + +TC+C G+ G C + +C + C NGG C D Y C CP Y G CE
Sbjct: 305 QRS-YTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST 363
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPR--CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
C+ +PC + C G CEC P + G NC + D C + C NG QC++
Sbjct: 364 LSCAD--SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRG 421
Query: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
S C C G++G CE+ H+ S C C +G C D N +C C GF G C
Sbjct: 422 PSRMCRCRPGFTGTYCEL--HV----SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRC 475
Query: 1163 EKLLSVN 1169
E S++
Sbjct: 476 EVRTSID 482
Score = 136 bits (342), Expect = 2e-31
Identities = 78/242 (32%), Positives = 110/242 (45%), Gaps = 30/242 (12%)
Query: 928 LCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL--DSCSSGPCENGGTCHAQEGE 985
+CLS + G C + P E C C G++GR C + + C G C
Sbjct: 221 ICLSGCHEQNGYC-SKPAE---CLCRPGWQGRLCNECIPHNGCRHGTCST---------- 266
Query: 986 DAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCVD-GVGNYTCQCPLQYEGKACEQL 1043
P+ C+C G+ G C + + C H+ C NG C + G +YTC C Y G CE
Sbjct: 267 --PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE-- 322
Query: 1044 VDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMD--E 1101
++L D NPC++ C DG C C PGY G +C + C D C NG C + +
Sbjct: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
Query: 1102 VNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPE 1161
+Y+C C ++G CE C C NG C+++G +C+C PGF G
Sbjct: 383 GANYACECPPNFTGSNCE------KKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTY 436
Query: 1162 CE 1163
CE
Sbjct: 437 CE 438
Score = 95.1 bits (235), Expect = 5e-19
Identities = 51/143 (35%), Positives = 65/143 (45%), Gaps = 13/143 (9%)
Query: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHN-DPLEVYRCACPSGYKGRDCEVSLDS 967
+ C+ PP + K D C S+PC N G C N P + C C G+ G CE+ +
Sbjct: 386 YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM--CRCRPGFTGTYCELHVSD 443
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNT--DDCVDHACANGGVCVDGVG 1025
C+ PC +GGTCH E C+CP GF G C V T D C C N C +
Sbjct: 444 CARNPCAHGGTCHDLEN---GLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS 500
Query: 1026 --NYTCQCPLQYEGKACEQLVDL 1046
+ C CP + G CE V L
Sbjct: 501 TDTFVCNCPYGFVGSRCEFPVGL 523
Score = 71.2 bits (173), Expect = 7e-12
Identities = 43/119 (36%), Positives = 55/119 (46%), Gaps = 9/119 (7%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQD 1405
C HG C +TP C C+ GW GL CDQ + H C +G C SY+C C+
Sbjct: 259 CRHGTC---STPW-QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRP 314
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES-ECRGDP 1463
GY+G C L+E C C +G G HC+C PG+ G CE + C P
Sbjct: 315 GYTGVDCEL--ELSE-CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP 370
Score = 58.2 bits (139), Expect = 6e-08
Identities = 57/229 (24%), Positives = 81/229 (35%), Gaps = 59/229 (25%)
Query: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQP-ADGPCHGHK---------------------- 1385
H +CQP+ C GW G +C QP CH
Sbjct: 197 HYVCQPDGN----LSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNE 252
Query: 1386 ------CVHGQCVPLDALSYSCQCQDGYSGALCNQAGALA---EPCRGLQCLHGHCQASG 1436
C HG C + + C C +G+ G C+Q PC+ C SG
Sbjct: 253 CIPHNGCRHGTC----STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKN----GATCSNSG 304
Query: 1437 TKGAHCVCDPGFSGELCEQE-SECRGDPVRD---FHQVQRGYAICQTTRPLSWVECRG-- 1490
+ C C PG++G CE E SEC +P R+ + GY C + C
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYH-CLCPPGYYGLHCEHST 363
Query: 1491 -SCPGQGCCQGLRLKRR----KFTFECS---DGTSFAEEVEKPTKCGCA 1531
SC C G + R + EC G++ ++V++ T CA
Sbjct: 364 LSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCA 412
Score = 56.6 bits (135), Expect = 2e-07
Identities = 36/128 (28%), Positives = 54/128 (42%), Gaps = 13/128 (10%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP----ADGPC-HGHKCVHGQCVPLDA 1396
C C +G + G C C G+ GLHC+ AD PC +G C
Sbjct: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERN----QG 383
Query: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-Q 1455
+Y+C+C ++G+ C + + C C +G + C C PGF+G CE
Sbjct: 384 ANYACECPPNFTGSNCEKK---VDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELH 440
Query: 1456 ESECRGDP 1463
S+C +P
Sbjct: 441 VSDCARNP 448
Score = 51.6 bits (122), Expect = 6e-06
Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 6/94 (6%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQAGALAE 1420
C C + G +C++ D C + C +G QC+ S C+C+ G++G C
Sbjct: 388 CECPPNFTGSNCEKKVDR-CTSNPCANGGQCLNRGP-SRMCRCRPGFTGTYCELH---VS 442
Query: 1421 PCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
C C HG G C C GFSG CE
Sbjct: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
Score = 48.9 bits (115), Expect = 4e-05
Identities = 45/155 (29%), Positives = 54/155 (34%), Gaps = 55/155 (35%)
Query: 1068 RCECMPGYAGDNCS----ENQDDCRDHRCQ-----------NGAQCMD--------EVNS 1104
R C Y GDNCS + D + CQ G C E N
Sbjct: 172 RVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG 231
Query: 1105 Y-----SCLCAEGYSGQLC-EIPPHLPAPKSPC---------EG---------------- 1133
Y CLC G+ G+LC E PH C EG
Sbjct: 232 YCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHH 291
Query: 1134 TECQNGANCVDQGNRP-VCQCLPGFGGPECEKLLS 1167
+ C+NGA C + G R C C PG+ G +CE LS
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS 326
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 6/116 (5%)
Query: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLDALSYS 1400
C C +G N P MC C G+ G +C+ C + C H G C L+
Sbjct: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV-SDCARNPCAHGGTCHDLEN-GLM 463
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQAS-GTKGAHCVCDPGFSGELCE 1454
C C G+SG C ++ + C C + C T C C GF G CE
Sbjct: 464 CTCPAGFSGRRCEVRTSI-DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 45.8 bits (107), Expect = 3e-04
Identities = 25/68 (36%), Positives = 34/68 (50%), Gaps = 9/68 (13%)
Query: 898 DMEGKLLLTTPA--KKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHND-PLEVYRCACPS 954
D+E L+ T PA C+ V+ D C SSPC N+ TC+ D + + C CP
Sbjct: 457 DLENGLMCTCPAGFSGRRCE------VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPY 510
Query: 955 GYKGRDCE 962
G+ G CE
Sbjct: 511 GFVGSRCE 518
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 179 bits (453), Expect = 2e-44
Identities = 140/457 (30%), Positives = 222/457 (48%), Gaps = 25/457 (5%)
Query: 11 AGPVRPELWLLLWAAAWRLGAS--ACPALCTCT-GTTVDCHGTGLQAIPKNIPRNTERLE 67
A P++ L LL+ AW G + CP+ CTC+ + V+C G + A+P +P N L+
Sbjct: 6 AMPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQ 65
Query: 68 LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPEL 127
+ +IT ++++ F + L L++ +N++ + GAF ++ L L L N+L +LP
Sbjct: 66 ILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIG 125
Query: 128 LFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLT 187
LFQ +L L LS N + I F ++LK LQL N + I +GAF L GL L
Sbjct: 126 LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLN 185
Query: 188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-----CDCHLAWLSQWLRQRPTIGLFTQ- 241
L N++T I F H+ L+ RL+ N L L L + Q+ IGL +
Sbjct: 186 LGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 245
Query: 242 -CSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 300
+L+ L ++ S+ S + ++ TL S + S GI
Sbjct: 246 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL---SLGIF------- 295
Query: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
+P + E+ L N I S+P FS R+L+ + LS NQI+ I+P AF GL L
Sbjct: 296 ----GPMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELR 350
Query: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
L L+ N + DL VF L LQ + L N++ + + F ++ L + L +N++++L
Sbjct: 351 ELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENL 410
Query: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTN 457
G F L + L L NP+ CD ++ L ++L N
Sbjct: 411 PLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 447
Score = 147 bits (371), Expect = 8e-35
Identities = 125/446 (28%), Positives = 201/446 (45%), Gaps = 22/446 (4%)
Query: 277 LSSGSCPAMCTCSNGI-VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
L+ CP+ CTCS V+C G + A+P LP +++ I + F L
Sbjct: 26 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85
Query: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
+ + N+++ I P AF+ L SL L L NK+ LP G+F GL +L+ LLL++N++
Sbjct: 86 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP--------FICDCNL 447
I+P F NL L L+ N ++ + G F L + L+L +N F NL
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205
Query: 448 KWLADF---LRTNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDYQ 502
+ L + L P+ T G L +IG + F + ++ ++ Q
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265
Query: 503 LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFK 562
L + ++ N ++ SL + + EL L +N IS L +F
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL----RELWLYDNHISSLP-DNVFS 320
Query: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRN 622
L L+ + LS N++S I GAF G + EL L N L+ + +FR L L+ + L+N
Sbjct: 321 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 380
Query: 623 NRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWL 682
NR+ + + F + + + L +NQ+ + G FD L L L L NP+ C+ + L
Sbjct: 381 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 440
Query: 683 GGWLRKRKIVTGN---PRCQNPDFLR 705
WL + G P C +P +R
Sbjct: 441 RNWLLLNQPRLGTDTVPVCFSPANVR 466
Score = 129 bits (324), Expect = 2e-29
Identities = 108/363 (29%), Positives = 169/363 (46%), Gaps = 17/363 (4%)
Query: 513 CPHKCRCE-ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571
CP +C C A+ VEC+ ++ +P +P + L++ N I+ L + F ++ L +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP-FLNISALIALR 89
Query: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631
+ N++S I GAF S+ L L N+L+ + G+F+GLD L +L+L +N++ I
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAW--LGGWLRKR 689
F+ N++ L L+ N + + GAFD L L+ LNL N + LG R
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209
Query: 690 KIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN 749
F + LQ++A + + G G Q + SN
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQ--QNQIGLLSPGLFHNNHNLQR-------LYLSN 260
Query: 750 KHLRALPKGI---PKNVTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFT 805
H+ LP I + L L GN L G L+ + L +N ISSL ++ F+
Sbjct: 261 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 320
Query: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
N+ QL LILS N + I P AF GL LR LSLH N + L +F + +L ++++
Sbjct: 321 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 380
Query: 866 NPL 868
N L
Sbjct: 381 NRL 383
Score = 99.8 bits (247), Expect = 2e-20
Identities = 59/189 (31%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 65 RLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML 124
RL L GN++ + F + LR L L +N I ++ F ++++L+ L L+RNQ+ +
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 338
Query: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
F L L L NA+Q + FR +L+N+ L N++ + F + GL
Sbjct: 339 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 398
Query: 185 VLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW-LRQRPTIGLFT--Q 241
+ L NN + +P+ F+H+ KL RL+ N CD + L W L +P +G T
Sbjct: 399 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 458
Query: 242 CSGPASLRG 250
C PA++RG
Sbjct: 459 CFSPANVRG 467
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/172 (27%), Positives = 69/172 (40%), Gaps = 26/172 (15%)
Query: 723 QEEGGCLPRPQCPQECACLD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFT------- 774
Q G L CP EC C + V C+ + A+P +P N L + T
Sbjct: 20 QAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPF 79
Query: 775 ------------------LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILS 816
+ PG L+ + L+NNK+ L F + L +L+LS
Sbjct: 80 LNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS 139
Query: 817 YNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
N L I P F +L+ L LHGN + + +G F + L+ L +G N L
Sbjct: 140 SNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 191
Score = 55.1 bits (131), Expect = 5e-07
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 52 LQAIPKNIPRNTERLE---LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDM 108
+ ++P N+ N +L+ L+ N I+ I F GL +LR L L N + ++ F +
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 370
Query: 109 KELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQ 168
L+ + L N+L LP +F N L + L N ++ +P F L L+L N
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430
Query: 169 ISCIEEGAFRALRGLEVLTLNNNNITTIPV 198
C + LR +L T+PV
Sbjct: 431 WRC--DSDILPLRNWLLLNQPRLGTDTVPV 458
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 178 bits (452), Expect = 3e-44
Identities = 139/455 (30%), Positives = 221/455 (48%), Gaps = 25/455 (5%)
Query: 13 PVRPELWLLLWAAAWRLGAS--ACPALCTCT-GTTVDCHGTGLQAIPKNIPRNTERLELN 69
P++ L LL+ AW G + CP+ CTC+ + V+C G + A+P +P N L++
Sbjct: 2 PLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQIL 61
Query: 70 GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLF 129
+IT ++++ F + L L++ +N++ + GAF ++ L L L N+L +LP LF
Sbjct: 62 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLF 121
Query: 130 QNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLN 189
Q +L L LS N + I F ++LK LQL N + I +GAF L GL L L
Sbjct: 122 QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLG 181
Query: 190 NNNITTIPVSSFNHMPKLRTFRLHSNHLF-----CDCHLAWLSQWLRQRPTIGLFTQ--C 242
N++T I F H+ L+ RL+ N L L L + Q+ IGL +
Sbjct: 182 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLF 241
Query: 243 SGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTA 302
+L+ L ++ S+ S + ++ TL S + S GI
Sbjct: 242 HNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL---SLGIF--------- 289
Query: 303 IPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSL 362
+P + E+ L N I S+P FS R+L+ + LS NQI+ I+P AF GL L L
Sbjct: 290 --GPMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 346
Query: 363 VLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAK 422
L+ N + DL VF L LQ + L N++ + + F ++ L + L +N++++L
Sbjct: 347 SLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL 406
Query: 423 GTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTN 457
G F L + L L NP+ CD ++ L ++L N
Sbjct: 407 GIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 441
Score = 147 bits (371), Expect = 8e-35
Identities = 125/446 (28%), Positives = 201/446 (45%), Gaps = 22/446 (4%)
Query: 277 LSSGSCPAMCTCSNGI-VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
L+ CP+ CTCS V+C G + A+P LP +++ I + F L
Sbjct: 20 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
Query: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
+ + N+++ I P AF+ L SL L L NK+ LP G+F GL +L+ LLL++N++
Sbjct: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP--------FICDCNL 447
I+P F NL L L+ N ++ + G F L + L+L +N F NL
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
Query: 448 KWLADF---LRTNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDYQ 502
+ L + L P+ T G L +IG + F + ++ ++ Q
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Query: 503 LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFK 562
L + ++ N ++ SL + + EL L +N IS L +F
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL----RELWLYDNHISSLP-DNVFS 314
Query: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRN 622
L L+ + LS N++S I GAF G + EL L N L+ + +FR L L+ + L+N
Sbjct: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
Query: 623 NRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWL 682
NR+ + + F + + + L +NQ+ + G FD L L L L NP+ C+ + L
Sbjct: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 434
Query: 683 GGWLRKRKIVTGN---PRCQNPDFLR 705
WL + G P C +P +R
Sbjct: 435 RNWLLLNQPRLGTDTVPVCFSPANVR 460
Score = 129 bits (324), Expect = 2e-29
Identities = 108/363 (29%), Positives = 169/363 (46%), Gaps = 17/363 (4%)
Query: 513 CPHKCRCE-ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571
CP +C C A+ VEC+ ++ +P +P + L++ N I+ L + F ++ L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP-FLNISALIALR 83
Query: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631
+ N++S I GAF S+ L L N+L+ + G+F+GLD L +L+L +N++ I
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAW--LGGWLRKR 689
F+ N++ L L+ N + + GAFD L L+ LNL N + LG R
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
Query: 690 KIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN 749
F + LQ++A + + G G Q + SN
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQ--QNQIGLLSPGLFHNNHNLQR-------LYLSN 254
Query: 750 KHLRALPKGI---PKNVTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFT 805
H+ LP I + L L GN L G L+ + L +N ISSL ++ F+
Sbjct: 255 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 314
Query: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
N+ QL LILS N + I P AF GL LR LSLH N + L +F + +L ++++
Sbjct: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
Query: 866 NPL 868
N L
Sbjct: 375 NRL 377
Score = 99.8 bits (247), Expect = 2e-20
Identities = 59/189 (31%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 65 RLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML 124
RL L GN++ + F + LR L L +N I ++ F ++++L+ L L+RNQ+ +
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
Query: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
F L L L NA+Q + FR +L+N+ L N++ + F + GL
Sbjct: 333 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 392
Query: 185 VLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW-LRQRPTIGLFT--Q 241
+ L NN + +P+ F+H+ KL RL+ N CD + L W L +P +G T
Sbjct: 393 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 452
Query: 242 CSGPASLRG 250
C PA++RG
Sbjct: 453 CFSPANVRG 461
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/172 (27%), Positives = 69/172 (40%), Gaps = 26/172 (15%)
Query: 723 QEEGGCLPRPQCPQECACLD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFT------- 774
Q G L CP EC C + V C+ + A+P +P N L + T
Sbjct: 14 QAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPF 73
Query: 775 ------------------LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILS 816
+ PG L+ + L+NNK+ L F + L +L+LS
Sbjct: 74 LNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS 133
Query: 817 YNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
N L I P F +L+ L LHGN + + +G F + L+ L +G N L
Sbjct: 134 SNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
Score = 55.1 bits (131), Expect = 5e-07
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 52 LQAIPKNIPRNTERLE---LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDM 108
+ ++P N+ N +L+ L+ N I+ I F GL +LR L L N + ++ F +
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
Query: 109 KELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQ 168
L+ + L N+L LP +F N L + L N ++ +P F L L+L N
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424
Query: 169 ISCIEEGAFRALRGLEVLTLNNNNITTIPV 198
C + LR +L T+PV
Sbjct: 425 WRC--DSDILPLRNWLLLNQPRLGTDTVPV 452
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 174 bits (442), Expect = 5e-43
Identities = 140/493 (28%), Positives = 204/493 (41%), Gaps = 71/493 (14%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACP-SGYKGRDCEVSLDSCSSGPCENGGTCHA 981
Q D C S PC + GTCH D + +RC C +GY+G CE + C+S PCE+ +C
Sbjct: 182 QLDLDECQSQPCAHGGTCH-DLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLE 240
Query: 982 QEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVD--------GV--------- 1024
G F C C G+ G C V+ D+C C +GG C+ GV
Sbjct: 241 GLGS---FRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFS 297
Query: 1025 ----GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
+ C CP +EG C VD C+ PC + C P+G +C C GYAG C
Sbjct: 298 FRHAAGFLCHCPPGFEGADCGVEVDECAS--RPCLNGGHCQDLPNGFQCHCPDGYAGPTC 355
Query: 1081 SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA 1140
E+ D+C C +G C D V Y C C E + G+ C + + C+G C A
Sbjct: 356 EEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSV------QLTGCQGHTCPLAA 409
Query: 1141 NCV---DQG-NRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVST 1196
C+ + G + VC C PG GP C + + + V + +Q + P + L+ T
Sbjct: 410 TCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFS-VMAGSPIQASVPAGGP-LGLALRFRT 467
Query: 1197 AEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAI---YSAETINDGQFHTVELVA 1253
G L D ++EL + SY ++ + +NDG +H VE+V
Sbjct: 468 TLPAGTLATRNDTKE-SLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVL 526
Query: 1254 FDQMVNLSI-DGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHG 1312
+ L + G P + L S A +P ++SA L F G
Sbjct: 527 HLATLELRLWHEGCPARLCVASGPVALASTAS--ATPLPAGISSAQ------LGDATFAG 578
Query: 1313 CIRNLYINNELQDFTKTQMKPGVVPGC---EPCRKLYCLHGICQPNATPGPMCHCEAGWV 1369
C++++ ++ L + V+ GC E CR L C+HG C W
Sbjct: 579 CLQDVRVDGHL--LLPEDLGENVLLGCERREQCRPLPCVHG-----------GSCVDLWT 625
Query: 1370 GLHCD--QPADGP 1380
CD +P GP
Sbjct: 626 HFRCDCARPHRGP 638
Score = 153 bits (386), Expect = 1e-36
Identities = 86/262 (32%), Positives = 111/262 (42%), Gaps = 23/262 (8%)
Query: 903 LLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCE 962
LLL PA P+ A C S PC C Y C P +G
Sbjct: 20 LLLWAPALSLLAGTVPSEPPSA----CASDPCAPGTECQATESGGYTCG-PMEPRG---- 70
Query: 963 VSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVD 1022
C++ PC +G C Q + F C C GF+GP C ++ D+C C +G C +
Sbjct: 71 -----CATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRN 125
Query: 1023 GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSE 1082
Y C CPL Y G CE VD C+ PC H C+ RC C PGY G C
Sbjct: 126 LADRYECHCPLGYAGVTCEMEVDECAS--APCLHGGSCLDGVGSFRCVCAPGYGGTRCQL 183
Query: 1083 NQDDCRDHRCQNGAQCMDEVNSYSCLCA-EGYSGQLCEIPPHLPAPKSPCEGTECQNGAN 1141
+ D+C+ C +G C D VN + C CA GY G CE C C++ A+
Sbjct: 184 DLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE------REVLECASAPCEHNAS 237
Query: 1142 CVDQGNRPVCQCLPGFGGPECE 1163
C++ C C PG+ G CE
Sbjct: 238 CLEGLGSFRCLCWPGYSGELCE 259
Score = 99.8 bits (247), Expect = 2e-20
Identities = 53/161 (32%), Positives = 69/161 (42%), Gaps = 4/161 (2%)
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNY 1027
C+ PC + G C ++ DA F C+C G+EGP C + D C CA G G +
Sbjct: 1060 CAPSPCLHDGAC--RDLFDA-FACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF 1116
Query: 1028 TCQCPLQYEGKACEQLVDLCSPDLN-PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDD 1086
C+CP + G C V LN C + C G C C+ G AG C
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176
Query: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAP 1127
C + C NG C C+C +SGQ CE+ LP P
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLP 1217
Score = 96.7 bits (239), Expect = 2e-19
Identities = 57/177 (32%), Positives = 76/177 (42%), Gaps = 18/177 (10%)
Query: 907 TPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLD 966
TPA C+G P +C SPC + G C D + + CAC G++G CE +D
Sbjct: 1047 TPAPILGCRGAP---------VCAPSPCLHDGACR-DLFDAFACACGPGWEGPRCEAHVD 1096
Query: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC--GVNTDDC-VDHACANGGVCVDG 1023
C S PC G CH D F C CP GF GP C V + +C ++ C +G C G
Sbjct: 1097 PCHSAPCAR-GRCHTH--PDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGG 1153
Query: 1024 VGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
C C G+ C+ V + NPC + C C C ++G C
Sbjct: 1154 SPAANCSCLEGLAGQRCQ--VPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 87.8 bits (216), Expect = 7e-17
Identities = 51/159 (32%), Positives = 67/159 (42%), Gaps = 13/159 (8%)
Query: 1009 CVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP- 1067
C C + G C D + C C +EG CE VD C PC +C PDG
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSA--PCAR-GRCHTHPDGRF 1116
Query: 1068 RCECMPGYAGDNCS---ENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHL 1124
C C PG+ G C +++ + C +G+ C + +C C EG +GQ C++P
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPT-- 1174
Query: 1125 PAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
PCE C NG C G C C F G CE
Sbjct: 1175 ----LPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 74.3 bits (181), Expect = 8e-13
Identities = 112/497 (22%), Positives = 163/497 (32%), Gaps = 115/497 (23%)
Query: 1083 NQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANC 1142
++D C C NG C+ N + C C ++G C A + C G C A C
Sbjct: 807 SEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC-------AQQLWCPGQPCLPPATC 859
Query: 1143 VDQGNRPVCQCLPGF-GGPECEKL------------LSVNFVDRDTYLQFTDLQNWPRAN 1189
+ + VC F GP LS+ F RD+ + W
Sbjct: 860 EEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDS-------EAW---- 908
Query: 1190 ITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAI-YSAETINDGQFHT 1248
L+ + G+ L N +A + GH P + + + DG +H
Sbjct: 909 -LLRAAAGALEGVWL-AVRNGSLAGGVRGGH--------GLPGAVLPIPGPRVADGAWHR 958
Query: 1249 VEL-----VAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDV----NSAAF 1299
V L A L +DG + P+ + G+ D+ A
Sbjct: 959 VRLAMERPAATTSRWLLWLDGAA----------------TPVALRGLASDLGFLQGPGAV 1002
Query: 1300 RLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEP------------------ 1341
R IL F GC+ + + + +PG PG
Sbjct: 1003 R---ILLAENFTGCLGRVALGG--LPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGA 1057
Query: 1342 --CRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS 1398
C CLH G C+ + C C GW G C+ D PCH C G+C
Sbjct: 1058 PVCAPSPCLHDGACR-DLFDAFACACGPGWEGPRCEAHVD-PCHSAPCARGRCHTHPDGR 1115
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES- 1457
+ C+C G+ G C E + CL G G+ A+C C G +G+ C+ +
Sbjct: 1116 FECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTL 1175
Query: 1458 ECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC--CQGLRLKRRKFTFECSDG 1515
C +P + C+ +S C GQ C +GL L F
Sbjct: 1176 PCEANPCLN-------GGTCRAAGGVSECICNARFSGQFCEVAKGLPL---PLPFPLL-- 1223
Query: 1516 TSFAEEVEKPTKCGCAL 1532
EV P C C L
Sbjct: 1224 -----EVAVPAACACLL 1235
Score = 70.5 bits (171), Expect = 1e-11
Identities = 54/202 (26%), Positives = 69/202 (34%), Gaps = 54/202 (26%)
Query: 1337 PGCE----PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCV 1392
P CE C C HG N CHC G+ G+ C+ D C C+HG
Sbjct: 103 PRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVD-ECASAPCLHGGSC 161
Query: 1393 PLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHG------------HCQASGTKGA 1440
S+ C C GY G C + C+ C HG C +G +G
Sbjct: 162 LDGVGSFRCVCAPGYGGTRCQLD---LDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGT 218
Query: 1441 HC---------------------------VCDPGFSGELCE-QESECRGDPVRDFHQVQR 1472
HC +C PG+SGELCE E EC P Q
Sbjct: 219 HCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSP------CQH 272
Query: 1473 GYAICQTTRPLSWVECRGSCPG 1494
G Q + P + + + PG
Sbjct: 273 GGRCLQRSDPALYGGVQAAFPG 294
Score = 57.0 bits (136), Expect = 1e-07
Identities = 40/111 (36%), Positives = 48/111 (43%), Gaps = 22/111 (19%)
Query: 906 TTPAKKFECQGPP-------TLAVQAK-CDL---CLS-SPCQNQGTCHNDPLEVYRCACP 953
T P +FEC+ PP L V +K C L CL SPC+ N C+C
Sbjct: 1110 THPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAAN-------CSCL 1162
Query: 954 SGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGV 1004
G G+ C+V C + PC NGGTC A G C C F G C V
Sbjct: 1163 EGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVS---ECICNARFSGQFCEV 1210
Score = 56.2 bits (134), Expect = 2e-07
Identities = 44/146 (30%), Positives = 58/146 (39%), Gaps = 31/146 (21%)
Query: 1345 LYCLHGICQPNAT-----PGPMCHCEAGWVGLHC----DQPADGPC-HGHKCVHGQCVPL 1394
L C C+ NA+ C C G+ G C D+ A PC HG +C+ L
Sbjct: 225 LECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPAL 284
Query: 1395 ---------------DALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHG-HCQASGTK 1438
A + C C G+ GA C G + C CL+G HCQ
Sbjct: 285 YGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADC---GVEVDECASRPCLNGGHCQDL-PN 340
Query: 1439 GAHCVCDPGFSGELCEQE-SECRGDP 1463
G C C G++G CE++ EC DP
Sbjct: 341 GFQCHCPDGYAGPTCEEDVDECLSDP 366
Score = 56.2 bits (134), Expect = 2e-07
Identities = 38/133 (28%), Positives = 52/133 (39%), Gaps = 11/133 (8%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C CL+G + G CHC G+ G C++ D C C+HG Y
Sbjct: 322 DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVD-ECLSDPCLHGGTCSDTVAGY 380
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQC-LHGHCQASGTKGAH---CVCDPGFSGELCEQ 1455
C+C + + G C+ C+G C L C G H C C PG G C Q
Sbjct: 381 ICRCPETWGGRDCS---VQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQ 437
Query: 1456 E---SECRGDPVR 1465
S G P++
Sbjct: 438 NTTFSVMAGSPIQ 450
Score = 48.9 bits (115), Expect = 4e-05
Identities = 31/92 (33%), Positives = 37/92 (40%), Gaps = 10/92 (10%)
Query: 944 PLEVYRCACPSGYKGRDCE------VSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGF 997
PL + + PS GR VS D CS PC NGGTC + F C+CP F
Sbjct: 781 PLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWND---FHCTCPANF 837
Query: 998 EGPTCGVNTDDCVDHACANGGVCVDGVGNYTC 1029
GPTC C C C + + C
Sbjct: 838 TGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868
Score = 45.1 bits (105), Expect = 5e-04
Identities = 24/66 (36%), Positives = 29/66 (43%), Gaps = 3/66 (4%)
Query: 1004 VNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGT 1063
V+ D C C NGG C+ ++ C CP + G C Q L P PC A C
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQ--QLWCPG-QPCLPPATCEEV 862
Query: 1064 PDGPRC 1069
PDG C
Sbjct: 863 PDGFVC 868
Score = 43.5 bits (101), Expect = 0.002
Identities = 70/304 (23%), Positives = 113/304 (37%), Gaps = 60/304 (19%)
Query: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC-EKLLSVNF-----VDRDTYLQFTD 1181
+ C C +G +CVD C C GP C +++ + F ++L
Sbjct: 606 REQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFL---- 661
Query: 1182 LQNWPRANITLQ--VSTAEDNGILLY--NGDNDHIAVELYQGHVRVSYDPGSYPSSAIYS 1237
LQ P N+T+ + T E G+LL N + V L +G +R PG S A+
Sbjct: 662 LQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV-PG---SPAVVL 717
Query: 1238 AETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSA 1297
+DG H V L P + + G+H ++VGG + +S
Sbjct: 718 PGRWDDGLRHLVML------------SFGPDQLQDLGQH--------VHVGGRLLAADSQ 757
Query: 1298 AFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGIC--QPN 1355
+ G F GC+++L ++ F + P R+ + L C +
Sbjct: 758 PW-------GGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDM 810
Query: 1356 ATPGPMCH---CEAGWVGLHCDQPAD--GPCHGHK--CVHGQCVPLDALSYSCQCQDGYS 1408
+P P + C W HC PA+ GP + C C+P C++
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLP------PATCEEVPD 864
Query: 1409 GALC 1412
G +C
Sbjct: 865 GFVC 868
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/107 (32%), Positives = 44/107 (41%), Gaps = 19/107 (17%)
Query: 903 LLLTTPAKKFECQGPPTLAVQAKC---DLCLSSPCQNQGTC---HNDPLEVYRCACPSGY 956
L L ++ E G + + A C D+C PC N GTC ND + C CP+ +
Sbjct: 782 LPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWND----FHCTCPANF 837
Query: 957 KGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP--FTCSCPTGF-EGP 1000
G C L C PC TC E+ P F C F EGP
Sbjct: 838 TGPTCAQQL-WCPGQPCLPPATC-----EEVPDGFVCVAEATFREGP 878
Score = 36.2 bits (82), Expect = 0.25
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS 1104
D+CSPD PC + C+ T + C C + G C++ Q C C A C + +
Sbjct: 809 DMCSPD--PCFNGGTCLVTWNDFHCTCPANFTGPTCAQ-QLWCPGQPCLPPATCEEVPDG 865
Query: 1105 YSCL 1108
+ C+
Sbjct: 866 FVCV 869
Score = 35.8 bits (81), Expect = 0.33
Identities = 25/82 (30%), Positives = 30/82 (36%), Gaps = 11/82 (13%)
Query: 1386 CVHGQCVPLDALSYSCQCQD--GYSGALCNQAGALAEPCR-GLQCLHGHCQASGTKGAHC 1442
C C P CQ + GY+ G +PC G C+ Q G C
Sbjct: 42 CASDPCAP----GTECQATESGGYTCGPMEPRGCATQPCHHGALCVP---QGPDPTGFRC 94
Query: 1443 VCDPGFSGELCEQE-SECRGDP 1463
C PGF G CE + EC P
Sbjct: 95 YCVPGFQGPRCELDIDECASRP 116
Score = 31.6 bits (70), Expect = 6.2
Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Query: 1415 AGALAEP-CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDP 1463
AG ++E C C +G HC C F+G C Q+ C G P
Sbjct: 803 AGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQP 852
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 172 bits (436), Expect = 2e-42
Identities = 149/502 (29%), Positives = 225/502 (44%), Gaps = 35/502 (6%)
Query: 5 PGWGSSAGPVRPELWLLLWAAAWRLGA--------SACPALCTCTGTTVDCHGTGLQAIP 56
P G P R LLLW RL + C A CTC G ++DC G GL A+P
Sbjct: 4 PVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALP 63
Query: 57 KNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAV-ERGAFDDMKELERLR 115
++P T L L+ N ++ I F L L+ + L N++ AV GA + L
Sbjct: 64 GDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS--SHVVSLF 121
Query: 116 LNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEG 175
L N++ + + +L LDLS N I + F +K L L N+I +E G
Sbjct: 122 LQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181
Query: 176 AFRAL-RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAW-----LSQW 229
AF L R L L L+ N IT +PV +F +P+L L+ N + L + L
Sbjct: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
Query: 230 LRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCS 289
QR I T + GL+ V E++ + +G + T + + +
Sbjct: 241 KLQRNNISKLTD----GAFWGLSKMHVLHLEYNSLVEVNSGSLYGLT----ALHQLHLSN 292
Query: 290 NGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349
N I KG + + + E+ L N + + + + L + LS+N I+ IA
Sbjct: 293 NSIARIHRKGW-----SFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
Query: 350 PDAFQGLRSLNSLVLYGNKIT---DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQN 406
AF+GLRSL L L N+I+ + G F GL +L L L NKI + AF L+
Sbjct: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
Query: 407 LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET-SGAR 465
L L+L N I+S+ F ++ ++ LH++ + F+CDC LKWL +L ++ A
Sbjct: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT 467
Query: 466 CASPRRLANKRIGQIKSKKFRC 487
CA P L + I + + F C
Sbjct: 468 CAHPESLKGQSIFSVPPESFVC 489
Score = 127 bits (319), Expect = 8e-29
Identities = 138/497 (27%), Positives = 205/497 (41%), Gaps = 92/497 (18%)
Query: 245 PASLRGLNVAEVQKSEFSCSG-------------QGEAGRVPTCTLSSGSCPAMCTCSNG 291
P+ R LN++ + SE +G E VP+ +S ++ N
Sbjct: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNK 126
Query: 292 IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPD 351
I G L A + + + L LN I + F ++ ++L+ N+I +
Sbjct: 127 IRSVEGSQLKAYLS-----LEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181
Query: 352 AFQGL-RSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLL 410
AF GL RSL +L L N+IT LP F L L L LN N+I I FQ L +L +L
Sbjct: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
Query: 411 SLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPR 470
L N I L G F L + LHL N + N G
Sbjct: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLV------------EVNSGSLYGLTALHQL 288
Query: 471 RLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLK 530
L+N I +I K + K + N+ D E ++ E SSL
Sbjct: 289 HLSNNSIARIHRKGWSFCQKLHELV-----LSFNNLTRLD---------EESLAELSSLS 334
Query: 531 LTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVS-EIED--GAFEG 587
+ LRL++N IS + A G FK L L+ ++L +N++S IED GAF G
Sbjct: 335 V-------------LRLSHNSISHI-AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSG 380
Query: 588 AASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDN 647
S+S+L L N+++S+ F GL+GL L L N I + D+F ++N
Sbjct: 381 LDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN--------- 431
Query: 648 QITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKI---VTGNPRCQNPDFL 704
L L++ ++ F C+CQL WL WL R + VT C +P+ L
Sbjct: 432 ---------------LKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT--CAHPESL 474
Query: 705 RQIPLQDVAFPDFRCEE 721
+ + V F C++
Sbjct: 475 KGQSIFSVPPESFVCDD 491
Score = 107 bits (268), Expect = 7e-23
Identities = 91/354 (25%), Positives = 165/354 (46%), Gaps = 35/354 (9%)
Query: 567 LKKINLSNNKVSEIEDGAFEGAA-SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRI 625
+K++NL+ N++ +E GAF+G + S+ L L+ N++ + F+ L L L L NRI
Sbjct: 165 IKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRI 223
Query: 626 SCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGW 685
I +F GL ++ +L L N I+ ++ GAF L + L+L N L G
Sbjct: 224 RLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL-VEVNSGSLYGL 282
Query: 686 LRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVV 745
++ N + + +I + +F C++ E + +
Sbjct: 283 TALHQLHLSN------NSIARIHRKGWSF----CQKLHEL------------VLSFNNLT 320
Query: 746 RCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSL---SN 801
R + L L +++ L L N + + G + L+++DL +N+IS ++
Sbjct: 321 RLDEESLAEL-----SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
Query: 802 SSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL 861
+F+ + L+ L L N ++ + AF GL L L+L GN I ++Q F + +L L
Sbjct: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
Query: 862 AIGANPLYCDCHLRWLSSWVKTGYKEPGI-ARCAGPQDMEGKLLLTTPAKKFEC 914
I ++ CDC L+WL W+ + + A CA P+ ++G+ + + P + F C
Sbjct: 436 HISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/162 (27%), Positives = 66/162 (40%), Gaps = 25/162 (15%)
Query: 730 PRPQCPQECACLDTVVRCSNKHLRALPKGIPK------------------------NVTE 765
PR C C C + C + L ALP +P N+ E
Sbjct: 37 PRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQE 96
Query: 766 LYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPP 825
+YL+ N+ T VP + ++ + L +NKI S+ S L L LS N + +
Sbjct: 97 VYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRN 156
Query: 826 LAFQGLRSLRLLSLHGNDISTLQEGIFADVT-SLSHLAIGAN 866
F ++ L+L GN I TL+ G F ++ SL L + N
Sbjct: 157 TCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 169 bits (428), Expect = 2e-41
Identities = 85/246 (34%), Positives = 120/246 (48%), Gaps = 15/246 (6%)
Query: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
D C+ + C++ TC + L Y+C C S ++G CE + C PC+N TC
Sbjct: 735 DDCILNACEHNSTCKDLHLS-YQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKS- 792
Query: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLV 1044
+ C C +G+ G C ++C C NGG+C + G + C CP Y G+ C Q
Sbjct: 793 --YRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRY 850
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPR-CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN 1103
+LC NPC++ + C+ D + C C + G NC + DC CQ+ C D VN
Sbjct: 851 NLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVN 910
Query: 1104 SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
++ C+C G+SG LCEI + C C+N CVD NR C C P + GP CE
Sbjct: 911 NFRCICRPGFSGSLCEIEIN------ECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Query: 1164 KLLSVN 1169
L VN
Sbjct: 965 --LDVN 968
Score = 155 bits (393), Expect = 2e-37
Identities = 92/314 (29%), Positives = 131/314 (41%), Gaps = 83/314 (26%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTC--------- 979
CL CQ+ G C D + +RC C G+ G CE+ ++ CSS PC+N GTC
Sbjct: 894 CLFLSCQDYGDCE-DMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFC 952
Query: 980 HAQEGEDAPF--------------------------TCSCPTGFEGPTCGVNTDDCVDHA 1013
+ + PF C C G+ G C +N D+C+
Sbjct: 953 NCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEP 1012
Query: 1014 CANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLC--SPDLN------------------- 1052
C + GVC+DG+ +YTC C + G CE + C +P L+
Sbjct: 1013 CLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGT 1072
Query: 1053 --------------PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHR-----CQ 1093
PC +E C + G C C GY G C ++ D+C + C
Sbjct: 1073 STQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICL 1132
Query: 1094 NGAQCMDEV-NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQ 1152
NG C+D +++ C C G+SGQ CEI + C + C +GA+C D N VC+
Sbjct: 1133 NGGICVDGPGHTFDCRCLPGFSGQFCEININ------ECSSSPCLHGADCEDHINGYVCK 1186
Query: 1153 CLPGFGGPECEKLL 1166
C PG+ G CE L
Sbjct: 1187 CQPGWSGHHCENEL 1200
Score = 155 bits (391), Expect = 4e-37
Identities = 92/291 (31%), Positives = 122/291 (41%), Gaps = 25/291 (8%)
Query: 870 CDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLL-TTPAKKFECQGPPTLAVQA---- 924
C+C S W E I C M G L +T +F C PP Q
Sbjct: 795 CEC----TSGWTGQNCSEE-INECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQR 849
Query: 925 --KCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
CDL L +PC+N TC C C ++G++CE+ + C C++ G C
Sbjct: 850 YNLCDL-LHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDM 908
Query: 983 EGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042
F C C GF G C + ++C C N G CVD + C C +Y G CE
Sbjct: 909 VNN---FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCEL 965
Query: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
V+ C ++PC E CV DG C C PGY G NC N D+C C + C+D +
Sbjct: 966 DVNKCK--ISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGI 1023
Query: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQC 1153
N Y+C C G+ G CE + C C +G C + N C C
Sbjct: 1024 NHYTCDCKSGFFGTHCE------TNANDCLSNPCLHG-RCTELINEYPCSC 1067
Score = 152 bits (383), Expect = 3e-36
Identities = 92/299 (30%), Positives = 129/299 (43%), Gaps = 26/299 (8%)
Query: 866 NPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAK 925
N +C+C + + + + I+ C D E + T G + +
Sbjct: 948 NRFFCNCEPEYHGPFCELDVNKCKISPCL---DEENCVYRTDGYNCLCAPGYTGINCEIN 1004
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985
D CLS PC + G C D + Y C C SG+ G CE + + C S PC +G C E
Sbjct: 1005 LDECLSEPCLHDGVCI-DGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINE 1062
Query: 986 DAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVD 1045
+ CSC C + +DC C N G C +TC CP Y G CE+ +D
Sbjct: 1063 ---YPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSID 1119
Query: 1046 LCS-PDLNP--CQHEAQCVGTPDGPR----CECMPGYAGDNCSENQDDCRDHRCQNGAQC 1098
C+ P+LN C + CV DGP C C+PG++G C N ++C C +GA C
Sbjct: 1120 NCAEPELNSVICLNGGICV---DGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADC 1176
Query: 1099 MDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGF 1157
D +N Y C C G+SG CE + C C + C++ C C PGF
Sbjct: 1177 EDHINGYVCKCQPGWSGHHCE-------NELECIPNSCVHEL-CMENEPGSTCLCTPGF 1227
Score = 137 bits (345), Expect = 8e-32
Identities = 80/267 (29%), Positives = 116/267 (43%), Gaps = 42/267 (15%)
Query: 914 CQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPC 973
C G +++V C L LS C C+ Y+ CE+ + C S C
Sbjct: 608 CLGNHSISVHGLC-LALSHNCN--------------CSGLQRYERNICEIDTEDCKSASC 652
Query: 974 ENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQC-- 1031
+NG T G F C GF+G C ++ D+C H C NG C+D GNY CQC
Sbjct: 653 KNGTTSTHLRGY---FFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVP 709
Query: 1032 PLQ------------YEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDN 1079
P + Y G CEQ +D C LN C+H + C +C C+ + G+
Sbjct: 710 PFKVVDGFSCLCNPGYVGIRCEQDIDDCI--LNACEHNSTCKDLHLSYQCVCLSDWEGNF 767
Query: 1080 CSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNG 1139
C + ++C+ + C+N + C D SY C C G++GQ C + C+ C NG
Sbjct: 768 CEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCS------EEINECDSDPCMNG 821
Query: 1140 ANCVDQ--GNRPVCQCLPGFGGPECEK 1164
C + + VC C P + G C +
Sbjct: 822 GLCHESTIPGQFVCLCPPLYTGQFCHQ 848
Score = 117 bits (294), Expect = 7e-26
Identities = 71/228 (31%), Positives = 107/228 (46%), Gaps = 42/228 (18%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
CLS+PC + G C + + Y C+C + C++ ++ C+S PC N G C
Sbjct: 1046 CLSNPCLH-GRC-TELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG--- 1100
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHA-----CANGGVCVDGVGN-YTCQCPLQYEGKACEQ 1042
FTC CP G+ G C + D+C + C NGG+CVDG G+ + C+C + G+ CE
Sbjct: 1101 FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEI 1160
Query: 1043 LVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQN-------- 1094
++ CS +PC H A C +G C+C PG++G +C EN+ +C + C +
Sbjct: 1161 NINECSS--SPCLHGADCEDHINGYVCKCQPGWSGHHC-ENELECIPNSCVHELCMENEP 1217
Query: 1095 ---------------GAQCMDEVNSYSCLC-----AEGYSGQLCEIPP 1122
G C DE+ +CL + S Q IPP
Sbjct: 1218 GSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPP 1265
Score = 108 bits (270), Expect = 4e-23
Identities = 101/376 (26%), Positives = 149/376 (39%), Gaps = 58/376 (15%)
Query: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQ- 1145
C H C+N C+ + + C C YSG+LC+ + CE C NGA CV +
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--------ASCENNPCGNGATCVPKS 2390
Query: 1146 GNRPVCQCLPGFGGPECEKLLSV---NFVDRD--------TYLQFTDLQNWPRANITLQV 1194
G VC C G GP C +++ F D Y + +D+ ++ Q+
Sbjct: 2391 GTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQL 2450
Query: 1195 S---TAEDNGILLYNGDNDH-------IAVELYQGHVRVSYDPGSYPSSAIYSAETINDG 1244
+ +A N ++ + G H +AV L G V SY+ GS +S ++ G
Sbjct: 2451 ANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLG 2510
Query: 1245 QFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGM-----PVDVNSAAF 1299
HTV L F Q L +D ++ G+ LN + YVGG + N A F
Sbjct: 2511 -VHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADF 2569
Query: 1300 RLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPG---------CEPCRKLYCLHG 1350
+ GF GCI L + E + P P PC + C +G
Sbjct: 2570 K-------NGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNG 2622
Query: 1351 ICQPNATPGPMCHCEAGWVGLHCDQPAD--GPCHG--HKCVHG-QCVPLDALSYSCQCQD 1405
+ C+C GW G C + P H H C G C+ L Y+C C
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH-GYTCFCPL 2681
Query: 1406 GYSGALCNQAGALAEP 1421
G +G C QA ++++P
Sbjct: 2682 GTTGIYCEQALSISDP 2697
Score = 108 bits (269), Expect = 5e-23
Identities = 146/666 (21%), Positives = 223/666 (33%), Gaps = 176/666 (26%)
Query: 930 LSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPF 989
L++ C T NDP E +C ++G + C NG +C ++E + +
Sbjct: 503 LAANCTEDATYVNDP-EDNNSSCWFPHEG----------TKEICANGCSCLSEE-DSQEY 550
Query: 990 TCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSP 1049
C + G NT D ++ C + VC D + C C L Y G+ C VD C
Sbjct: 551 RYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLG 610
Query: 1050 DLN--------PCQHEAQCVGTPDGPR--CE---------------------------CM 1072
+ + H C G R CE C+
Sbjct: 611 NHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCV 670
Query: 1073 PGYAGDNCSENQDDCRDHRCQNGAQCMDE--------------VNSYSCLCAEGYSGQLC 1118
PG+ G C + D+C H C+NGA C+D+ V+ +SCLC GY G C
Sbjct: 671 PGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRC 730
Query: 1119 EIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGP-------ECE-KLLSVNF 1170
E C C++ + C D C CL + G EC+ N
Sbjct: 731 E------QDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNS 784
Query: 1171 VDRDTYLQFTD--LQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPG 1228
D Y + W N + +++ + + + NG H
Sbjct: 785 TCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCM--NGGLCH---------------ES 827
Query: 1229 SYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVG 1288
+ P + + GQF D + N + + + + + +H E + G
Sbjct: 828 TIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREE---FEG 884
Query: 1289 -GMPVDVNSAAFRLWQ-------ILNG------TGFHGCIRNLYINNELQDFTKTQ---- 1330
+DV F Q ++N GF G + + IN + K
Sbjct: 885 KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCV 944
Query: 1331 -MKPGVVPGCEP-------------CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP 1376
+ CEP C+ CL T G C C G+ G++C+
Sbjct: 945 DLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEIN 1004
Query: 1377 ADGPCHGHKCVH-GQCVPLDALS-YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGH--- 1431
D C C+H G C+ D ++ Y+C C+ G+ G C A C CLHG
Sbjct: 1005 LD-ECLSEPCLHDGVCI--DGINHYTCDCKSGFFGTHCE---TNANDCLSNPCLHGRCTE 1058
Query: 1432 --------CQASGT-----------------------KGAH---CVCDPGFSGELCEQES 1457
C A GT K AH C+C G++G CE+
Sbjct: 1059 LINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSI 1118
Query: 1458 ECRGDP 1463
+ +P
Sbjct: 1119 DNCAEP 1124
Score = 107 bits (268), Expect = 7e-23
Identities = 87/351 (24%), Positives = 131/351 (37%), Gaps = 27/351 (7%)
Query: 829 QGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEP 888
Q L RL +H + L G +T ++ + P C LR L+ VK + +
Sbjct: 123 QLLFGCRLKGMHTVNSKWLSVGTHYFITVMA-----SGPSPCPLGLR-LNVTVKQQFCQE 176
Query: 889 GIAR--CAGPQDMEGKLLLTTPAKKFECQGPPTLAVQ--AKCDLCLSSPCQNQGTCHND- 943
++ C+G GK L +K + C P + + + D C PC+N G+C N
Sbjct: 177 SLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
Query: 944 ---PLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGP 1000
+ Y C C + G++C + C C +G + F C C F GP
Sbjct: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS---FICECDEQFSGP 289
Query: 1001 TCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC 1060
C V+ CV G+C + YT +CP + E D+ L PCQ+ C
Sbjct: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGE--TDVSEFSLVPCQNGTDC 347
Query: 1061 VGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
+ + C C P + C Q C +N A C Y C C G++ + CE
Sbjct: 348 IKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE- 406
Query: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFV 1171
C N C + R C+PG C L +V +
Sbjct: 407 ---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLI 454
Score = 103 bits (256), Expect = 2e-21
Identities = 95/354 (26%), Positives = 140/354 (39%), Gaps = 47/354 (13%)
Query: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLC----------EIPPHLPAPKSPCEGTEC 1136
C +C NG C++ S C C G+ G C PPH C
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH-----------HC 2662
Query: 1137 QNGANCVDQGNRPVCQCLPGFGGPECEKLLSVN---FVDRD-TYLQFTDLQNWPRANITL 1192
GA C+ + C C G G CE+ LS++ F + +++ F + +I L
Sbjct: 2663 SRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQL 2722
Query: 1193 QVSTAEDNGILLYNGDN------DHIAVELYQGHVRVSYDPGSYPSSA-IYSAETINDGQ 1245
Q +GIL Y + D + + L V++ Y+ G TIN
Sbjct: 2723 QFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGST 2782
Query: 1246 FHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVD--VNSAAFRLWQ 1303
+H ++ L +DG + +T K +L++ Y+GG+ VN A
Sbjct: 2783 WHIIKAGRVGAEGYLDLDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEP 2841
Query: 1304 ILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPG-CE--PCRKLYCLHG-ICQPNATPG 1359
+ GF GCIR + INN+ T+ K G G C+ C C +G C N T
Sbjct: 2842 V----GFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTF 2897
Query: 1360 PMCHCEAGWVGLHCDQPADGPCHGHKCVHGQ-CVPLDALSYSCQCQDGYSGALC 1412
C C W G C+Q C + C+H C+P + SYSC C G+ G C
Sbjct: 2898 S-CRCLPDWAGNTCNQSVS--CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 75.5 bits (184), Expect = 4e-13
Identities = 88/346 (25%), Positives = 139/346 (40%), Gaps = 48/346 (13%)
Query: 1111 EGYSGQLCEIPPHLPAPKSPCEGTECQNGANC----VDQGNRPV-CQCLPGFGGPECEKL 1165
+G + P + AP S C+ C NG C + G C C F G CEK
Sbjct: 2084 QGVDTMWTSVSPSVAAP-SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
Query: 1166 LSVNF--VDRDTYLQFTDL------QNWPRANITLQVSTAEDNGILLY-NGDN---DHIA 1213
+ F + ++YL+ L ++ I L + T NG +LY NG+N +
Sbjct: 2143 AGLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLH 2202
Query: 1214 VELYQGHVRVSYDPGSYPSSAIYSAE-TINDGQFHTVELVAFDQ--------MVNLSIDG 1264
+ L +G V Y G+ + SA +IN F + + M+ ++ DG
Sbjct: 2203 LFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIEMTADG 2262
Query: 1265 GSPMTM-DNFGKHYTLNSEAPLYVGGMP--VDVNSAAFRLWQILNGTGFHGCIRNLYINN 1321
P+ D H + +++G +P V ++ A ++ GF GCI +L +NN
Sbjct: 2263 KPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVY------GFRGCILDLQVNN 2316
Query: 1322 ELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQP 1376
+ + F + + G E C +C H +C+ N T C C + G C
Sbjct: 2317 K-EFFIIDEARHG--KNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA 2373
Query: 1377 ADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
+ C + C +G CVP C C G SG LC A + +P
Sbjct: 2374 S---CENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 73.2 bits (178), Expect = 2e-12
Identities = 77/315 (24%), Positives = 108/315 (34%), Gaps = 89/315 (28%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLD---------------------- 966
C S P +N TC + Y C+C SG+ ++CE ++D
Sbjct: 374 CESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRF 432
Query: 967 ------SCSSGPC---EN-----------GGTCHA--QEGEDAPFTCSCPTGF---EGPT 1001
C+ PC +N G T H Q+ A F GF EG
Sbjct: 433 KYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEK 492
Query: 1002 CGVNTD-------DCVDHA-----------------------CANGGVCV--DGVGNYTC 1029
C D +C + A CANG C+ + Y
Sbjct: 493 CQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRY 552
Query: 1030 QCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDC-R 1088
C L++ G L + N CQHEA C + PRC C Y G C N D C
Sbjct: 553 LCFLRWAGNM--YLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLG 610
Query: 1089 DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNR 1148
+H C+ ++ +C + Y +CEI C+ C+NG
Sbjct: 611 NHSISVHGLCLALSHNCNCSGLQRYERNICEI------DTEDCKSASCKNGTTSTHLRGY 664
Query: 1149 PVCQCLPGFGGPECE 1163
+C+PGF G +CE
Sbjct: 665 FFRKCVPGFKGTQCE 679
Score = 68.9 bits (167), Expect = 3e-11
Identities = 45/141 (31%), Positives = 61/141 (43%), Gaps = 14/141 (9%)
Query: 1325 DFTKTQMKPGVVPGCEPCRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHG 1383
D T TQ K + C + C++ G CQ +A G C C G+ G +C++ D
Sbjct: 1070 DGTSTQCKIKI----NDCTSIPCMNEGFCQKSAH-GFTCICPRGYTGAYCEKSIDNCAEP 1124
Query: 1384 HK----CVHGQ-CVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTK 1438
C++G CV ++ C+C G+SG C C CLHG
Sbjct: 1125 ELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE---ININECSSSPCLHGADCEDHIN 1181
Query: 1439 GAHCVCDPGFSGELCEQESEC 1459
G C C PG+SG CE E EC
Sbjct: 1182 GYVCKCQPGWSGHHCENELEC 1202
Score = 63.2 bits (152), Expect = 2e-09
Identities = 30/74 (40%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C C+N GTC +D ++ C CP Y G+ C+ + SC + PC NG TC + G D
Sbjct: 2339 CAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTD-- 2393
Query: 989 FTCSCPTGFEGPTC 1002
C CP G GP C
Sbjct: 2394 IVCLCPYGRSGPLC 2407
Score = 62.4 bits (150), Expect = 3e-09
Identities = 58/249 (23%), Positives = 106/249 (42%), Gaps = 52/249 (20%)
Query: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM-DEVNSYSCLCA 1110
N C++ +C C C+P +AG+ C+++ C ++ C + + C+ D+ SYSCLC
Sbjct: 2882 NTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLCT 2940
Query: 1111 EGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNF 1170
G+ G+ CE K F G K + N+
Sbjct: 2941 LGWVGRYCENKTSFSTAK----------------------------FMGNSYIKYIDPNY 2972
Query: 1171 VDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLY-----NGDNDHIAVELYQGHVRVSY 1225
R+ LQFT I+L ST + G++++ N +ND +A+ L+ ++++
Sbjct: 2973 RMRN--LQFT--------TISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAV 3022
Query: 1226 DPG---SYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMT--MDNFGKHYTLN 1280
+ G S P S Y+ T ++H V ++ ++ I+ ++ +D LN
Sbjct: 3023 NLGERISVPMS--YNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALN 3080
Query: 1281 SEAPLYVGG 1289
+ Y+GG
Sbjct: 3081 YDGICYLGG 3089
Score = 58.5 bits (140), Expect = 5e-08
Identities = 31/87 (35%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC-----VDHACANGGVCVD 1022
CS C NGGTC + G C+C TG++G C C H C+ G C+
Sbjct: 2614 CSLMKCGNGGTC-IESGTSV--YCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670
Query: 1023 GVGNYTCQCPLQYEGKACEQLVDLCSP 1049
YTC CPL G CEQ + + P
Sbjct: 2671 LPHGYTCFCPLGTTGIYCEQALSISDP 2697
Score = 55.1 bits (131), Expect = 5e-07
Identities = 42/166 (25%), Positives = 61/166 (36%), Gaps = 47/166 (28%)
Query: 1347 CLHGICQPNATPGPM-----CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDAL--SY 1399
C C+ N+T + C C +GW G +C + + C C++G + +
Sbjct: 775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEIN-ECDSDPCMNGGLCHESTIPGQF 833
Query: 1400 SCQCQDGYSGALCNQAGALAE----PCRG-----------------------------LQ 1426
C C Y+G C+Q L + PCR
Sbjct: 834 VCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD 893
Query: 1427 CLHGHCQASG-----TKGAHCVCDPGFSGELCEQE-SECRGDPVRD 1466
CL CQ G C+C PGFSG LCE E +EC +P ++
Sbjct: 894 CLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKN 939
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 1014 CANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNP---CQHEAQCVGTPDGPRCE 1070
C NGG C++ + C C ++G C + V C P+ +P C A C+ P G C
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678
Query: 1071 CMPGYAGDNCSE 1082
C G G C +
Sbjct: 2679 CPLGTTGIYCEQ 2690
Score = 53.5 bits (127), Expect = 2e-06
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1349 HGICQPNA-TPGPMCHCEAGWVGLHC---DQPADGPCHGHKCVHGQCVPLDALSYSCQCQ 1404
HG C A + CHC+ + G +C D + PC + + D +Y C C
Sbjct: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
Query: 1405 DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
++G C++ + C+ C HG+C + C CD FSG CE
Sbjct: 246 PPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 934 CQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSC 993
C Q +N L++ G DC+ + +C C NGG C F+C C
Sbjct: 2847 CIRQVIINNQELQLTEFGAKGGSNVGDCDGT--ACGYNTCRNGGECTVN---GTTFSCRC 2901
Query: 994 PTGFEGPTCGVNTDDCVDHACANGGVCV-DGVGNYTCQCPLQYEGKACE 1041
+ G TC + C+++ C + +C+ D +Y+C C L + G+ CE
Sbjct: 2902 LPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 50.1 bits (118), Expect = 2e-05
Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 43/144 (29%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
C C + G +C + G C H C HG C + + S+ C+C + +SG C + A+P
Sbjct: 242 CVCHPPFTGKNCSEII-GQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS---AKP 297
Query: 1422 C-------RGL----------QCLHGHCQASG---------------------TKGAHCV 1443
C RG+ +C G +G + C+
Sbjct: 298 CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCI 357
Query: 1444 CDPGFSGELCEQ-ESECRGDPVRD 1466
C P F+ LC+ ++ C P+R+
Sbjct: 358 CSPIFTDLLCKSIQTSCESFPLRN 381
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 11/115 (9%)
Query: 1347 CLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
CL+G IC C C G+ G C+ + C C+HG Y C+CQ
Sbjct: 1131 CLNGGICVDGPGHTFDCRCLPGFSGQFCEININ-ECSSSPCLHGADCEDHINGYVCKCQP 1189
Query: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFS----GELCEQE 1456
G+SG C C C+H C + G+ C+C PGF G LC E
Sbjct: 1190 GWSGHHCENE----LECIPNSCVHELCMEN-EPGSTCLCTPGFMTCSIGLLCGDE 1239
Score = 47.4 bits (111), Expect = 1e-04
Identities = 40/147 (27%), Positives = 53/147 (36%), Gaps = 12/147 (8%)
Query: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKC-VHGQCVPLDALSYSCQCQ- 1404
C H + P C C ++G C D H VHG C+ ALS++C C
Sbjct: 575 CQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCL---ALSHNCNCSG 631
Query: 1405 -DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGD 1462
Y +C E C+ C +G C PGF G CE + EC
Sbjct: 632 LQRYERNICEID---TEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH 688
Query: 1463 PVRDFHQV--QRGYAICQTTRPLSWVE 1487
P ++ Q G CQ P V+
Sbjct: 689 PCKNGATCIDQPGNYFCQCVPPFKVVD 715
Score = 45.8 bits (107), Expect = 3e-04
Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 18/144 (12%)
Query: 1388 HGQCVPLD-ALSYSCQCQDGYSGALCNQAGALA-EPCRGLQCLHGHCQASGTKGAHCVCD 1445
HG+C+ + +YSC CQ +SG C + A + +PC+ + + CVC
Sbjct: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
Query: 1446 PGFSGELC-EQESECRGDPVRDFH----QVQRGYAICQTTRPLSWVECRGSCPGQGCCQG 1500
P F+G+ C E +C+ P FH + IC+ S C S + C
Sbjct: 246 PPFTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVS--AKPCVSL 301
Query: 1501 LRLKR-------RKFTFECSDGTS 1517
L KR +T+EC G+S
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSS 325
Score = 45.1 bits (105), Expect = 5e-04
Identities = 28/84 (33%), Positives = 36/84 (42%), Gaps = 14/84 (16%)
Query: 929 CLSSPCQ-----NQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCS-----SGPCENGGT 978
C +SPC N GTC VY C C +G+KG C ++ +C C G T
Sbjct: 2609 CHASPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 979 CHAQEGEDAPFTCSCPTGFEGPTC 1002
C + +TC CP G G C
Sbjct: 2668 CISL---PHGYTCFCPLGTTGIYC 2688
Score = 40.0 bits (92), Expect = 0.017
Identities = 55/268 (20%), Positives = 104/268 (38%), Gaps = 30/268 (11%)
Query: 1174 DTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIA----VELYQGHVRVSYD--- 1226
D+YL+F ++ P+ NI+L+ T G+LLY + ++ ++L+ + + Y
Sbjct: 1891 DSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYC 1950
Query: 1227 PGSYPSSAIYSAETINDGQFHTVELVAFDQMVN--LSIDGGSPMTMDNFGKHYTLNSEAP 1284
PG +I + +++GQ +T+ + N L+I G + ++ ++ L P
Sbjct: 1951 PGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESI--NHVLGKPLP 2008
Query: 1285 ----LYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGC- 1339
+++GG P D++ ++ + F GCI + INN +K + C
Sbjct: 2009 KSGSVFIGGFP-DLHG---KIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCR 2064
Query: 1340 ------EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVP 1393
P + Q T + C Q CH H +
Sbjct: 2065 SQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSV-CQQDV---CHNGGTCHAIFLS 2120
Query: 1394 LDALSYSCQCQDGYSGALCNQAGALAEP 1421
+S+ C C ++G C + L P
Sbjct: 2121 SGIVSFQCDCPLHFTGRFCEKDAGLFFP 2148
Score = 39.7 bits (91), Expect = 0.023
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 5/49 (10%)
Query: 1009 CVDHACANGGVC-----VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
C C NGG C G+ ++ C CPL + G+ CE+ L P N
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFN 2151
Score = 35.8 bits (81), Expect = 0.33
Identities = 16/37 (43%), Positives = 16/37 (43%), Gaps = 2/37 (5%)
Query: 968 CSSGPCENGGTCHA--QEGEDAPFTCSCPTGFEGPTC 1002
C C NGGTCHA F C CP F G C
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139
Score = 33.9 bits (76), Expect = 1.2
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 928 LCLSSPCQNQGTCH----NDPLEVYRCACPSGYKGRDCE 962
+C C N GTCH + + ++C CP + GR CE
Sbjct: 2102 VCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 33.1 bits (74), Expect = 2.1
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCE 962
CL++ C +Q C D Y C C G+ GR CE
Sbjct: 2916 CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 32.7 bits (73), Expect = 2.8
Identities = 33/128 (25%), Positives = 46/128 (35%), Gaps = 21/128 (16%)
Query: 1414 QAGALAEPCRGLQCLHGHCQASG-TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQV-- 1470
Q +E C G HG C + +K C C P FSG+ C++ C P ++
Sbjct: 175 QESLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
Query: 1471 ------QRGYAICQTTRPLSWVECR---GSCPGQGCCQG--LRLKRRKFTFECSDGTS-- 1517
++ Y C P + C G C C G + F EC + S
Sbjct: 231 KRENWDEQAYE-CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
Query: 1518 FAEEVEKP 1525
F E KP
Sbjct: 290 FCEVSAKP 297
Score = 32.0 bits (71), Expect = 4.7
Identities = 37/112 (33%), Positives = 44/112 (39%), Gaps = 8/112 (7%)
Query: 1419 AEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELC-EQESECRGDPVRD-FHQVQRGYA 1475
A PC ++C +G C SGT +C C G+ G C E S C DP D H RG A
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTS-VYCNCTTGWKGSFCTETVSTC--DPEHDPPHHCSRG-A 2666
Query: 1476 ICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAE-EVEKPT 1526
C + C G C Q L + F SFA V K T
Sbjct: 2667 TCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKT 2718
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 168 bits (425), Expect = 4e-41
Identities = 93/274 (33%), Positives = 124/274 (45%), Gaps = 48/274 (17%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C S PCQN GTC + + +RC CP+G+ G CE + C + C++GG C + G
Sbjct: 315 CASQPCQNGGTCTHG-INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAV- 372
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ----LV 1044
C C G+ G C ++ DDC C NGG CVD VGNYTC C ++G CE +
Sbjct: 373 --CVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVP 430
Query: 1045 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN-QDDCRDHRCQNGAQCMDEVN 1103
D C PC + CV G CEC G+ G +C E DDC C+NG +C+ N
Sbjct: 431 DACLSA--PCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLG-AN 484
Query: 1104 SYSCLCAEGYSGQLCE-----IPPHLPAP----------------------------KSP 1130
+ C C G+ G LCE +P ++ SP
Sbjct: 485 TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP 544
Query: 1131 CEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
C+ C NG +C + C+C GF G CEK
Sbjct: 545 CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEK 578
Score = 166 bits (419), Expect = 2e-40
Identities = 93/298 (31%), Positives = 119/298 (39%), Gaps = 67/298 (22%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL-DSCSSGPCENGGTCHA 981
+A+ LC S PC+N GTC E Y C+CP + GR CE+ DSC+SGPC NGGTC
Sbjct: 578 KARPHLCSSGPCRNGGTCKEAGGE-YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFH 636
Query: 982 QEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACE 1041
G+ + C CP GF G C + C C NGG C D ++ C C Y G+ C+
Sbjct: 637 YIGK---YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 693
Query: 1042 QLVD----------------------------------------LCSPD----------- 1050
VD +C P
Sbjct: 694 AEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLE 753
Query: 1051 -----LNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSY 1105
PC H C G C C GY G +C +D+CR H C+NG C + +Y
Sbjct: 754 IDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAY 813
Query: 1106 SCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
C C G+ G CE C+ + CQ+G C G +C C F G CE
Sbjct: 814 VCRCPAGFVGVHCE------TEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCE 865
Score = 162 bits (409), Expect = 3e-39
Identities = 92/244 (37%), Positives = 116/244 (47%), Gaps = 22/244 (9%)
Query: 928 LCLS-SPCQNQGTCHNDPLE---VYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQE 983
+CL+ PC N G C +D + Y C+C SG+ GR C + ++ C+S PC+NGGTC
Sbjct: 271 VCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTC--TH 328
Query: 984 GEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQL 1043
G ++ F C CP GF GPTC C C +GG C G+ C C Y G ACE
Sbjct: 329 GINS-FRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMD 387
Query: 1044 VDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQ----DDCRDHRCQNGAQCM 1099
VD CSPD PC + CV C C + G C D C C NG C+
Sbjct: 388 VDDCSPD--PCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCV 445
Query: 1100 DEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGG 1159
D Y C C EG+ G C +P + EC+NG C+ N +CQC GF G
Sbjct: 446 DADQGYVCECPEGFMGLDCR--ERVP------DDCECRNGGRCLG-ANTTLCQCPLGFFG 496
Query: 1160 PECE 1163
CE
Sbjct: 497 LLCE 500
Score = 161 bits (408), Expect = 4e-39
Identities = 77/194 (39%), Positives = 96/194 (49%), Gaps = 5/194 (2%)
Query: 972 PCENGGTCHAQEGEDAP-FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQ 1030
PC NGG C P +TCSC +GF G C ++ ++C C NGG C G+ ++ CQ
Sbjct: 277 PCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQ 336
Query: 1031 CPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDH 1090
CP + G CE C D CQH QC C C GY G C + DDC
Sbjct: 337 CPAGFGGPTCETAQSPC--DTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPD 394
Query: 1091 RCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV 1150
C NG C+D V +Y+CLCAE + G CE H P P + C C NG CVD V
Sbjct: 395 PCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDH-PVPDA-CLSAPCHNGGTCVDADQGYV 452
Query: 1151 CQCLPGFGGPECEK 1164
C+C GF G +C +
Sbjct: 453 CECPEGFMGLDCRE 466
Score = 145 bits (365), Expect = 4e-34
Identities = 87/301 (28%), Positives = 112/301 (37%), Gaps = 72/301 (23%)
Query: 925 KCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEG 984
K D C S PC N GTC + + Y+C CP G+ GR CE++ C PC NGGTC E
Sbjct: 619 KPDSCASGPCHNGGTCFHY-IGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTC---ED 674
Query: 985 EDAPFTC-----------------------------------------SCPTGF------ 997
D F C +C G+
Sbjct: 675 RDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPS 734
Query: 998 ------------EGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVD 1045
E P C + D+C C +GG C D V Y C C YEG CE D
Sbjct: 735 RIRVCQPHGVWSEPPQC-LEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERD 793
Query: 1046 LCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSY 1105
C +PC++ C P C C G+ G +C D C CQ+G +C +Y
Sbjct: 794 ECRA--HPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAY 851
Query: 1106 SCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
C+C E + G CE PC + C C+ C C G+ G +C K
Sbjct: 852 LCVCPESFFGYHCE------TVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKE 905
Query: 1166 L 1166
L
Sbjct: 906 L 906
Score = 135 bits (341), Expect = 2e-31
Identities = 101/318 (31%), Positives = 123/318 (38%), Gaps = 48/318 (15%)
Query: 864 GANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME-----GKLLLTTPAKKFECQGPP 918
G N C C G+ P P D + G+ + + CQ
Sbjct: 329 GINSFRCQC---------PAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGY 379
Query: 919 T-LAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVS----LDSCSSGPC 973
T A + D C PC N G+C D + Y C C +KG CE D+C S PC
Sbjct: 380 TGAACEMDVDDCSPDPCLNGGSCV-DLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPC 438
Query: 974 ENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPL 1033
NGGTC D + C CP GF G C D D C NGG C+ G CQCPL
Sbjct: 439 HNGGTC---VDADQGYVCECPEGFMGLDCRERVPD--DCECRNGGRCL-GANTTLCQCPL 492
Query: 1034 QYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPG------YAGDNCSEN-QDD 1086
+ G CE + PC QC PDG C G + N S +
Sbjct: 493 GFFGLLCEFEITAM-----PCNMNTQC---PDGGYCMEHGGSYLCVCHTDHNASHSLPSP 544
Query: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCE-IPPHLPAPKSPCEGTECQNGANCVDQ 1145
C C NG C +SY+C C G+ G+ CE PHL C C+NG C +
Sbjct: 545 CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHL------CSSGPCRNGGTCKEA 598
Query: 1146 GNRPVCQCLPGFGGPECE 1163
G C C F G CE
Sbjct: 599 GGEYHCSCPYRFTGRHCE 616
Score = 118 bits (296), Expect = 4e-26
Identities = 80/289 (27%), Positives = 107/289 (37%), Gaps = 64/289 (22%)
Query: 930 LSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS-CSSGPCENGGTCHAQEGEDAP 988
+++ C + G C Y C C + + SL S C S PC NGG+C A D
Sbjct: 510 MNTQCPDGGYCMEHGGS-YLCVCHTDHNASH---SLPSPCDSDPCFNGGSCDAH---DDS 562
Query: 989 FTCSCPTGFEGPTCG-VNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACE-QLVDL 1046
+TC CP GF G C C C NGG C + G Y C CP ++ G+ CE D
Sbjct: 563 YTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDS 622
Query: 1047 CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYS 1106
C+ PC + C +C+C PG++G +C C C NG C D +
Sbjct: 623 CAS--GPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFF 680
Query: 1107 CLCAEGYSGQLCEI-----PPH---------------------------LPAPK------ 1128
C C GY G+ C+ PP L AP
Sbjct: 681 CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQ 740
Query: 1129 --------------SPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
C C +G +C D+ +C C G+ G CE
Sbjct: 741 PHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCE 789
Score = 70.9 bits (172), Expect = 9e-12
Identities = 52/166 (31%), Positives = 70/166 (42%), Gaps = 18/166 (10%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLDALS 1398
+ CR CLHG + G +C C G+ G HC+ D C H C + G C L +
Sbjct: 755 DECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERD-ECRAHPCRNGGSCRNLPG-A 812
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQASGTKGAH-CVCDPGFSGELCEQE 1456
Y C+C G+ G C + C C H G C++ G GA+ CVC F G CE
Sbjct: 813 YVCRCPAGFVGVHCETE---VDACDSSPCQHGGRCESGG--GAYLCVCPESFFGYHCETV 867
Query: 1457 SE-CRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGL 1501
S+ C P RGY C + C+ G+ C + L
Sbjct: 868 SDPCFSSPCGG-----RGY--CLASNGSHSCTCKVGYTGEDCAKEL 906
Score = 63.9 bits (154), Expect = 1e-09
Identities = 30/80 (37%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQ 982
+ + D C SSPCQ+ G C + Y C CP + G CE D C S PC G C A
Sbjct: 827 ETEVDACDSSPCQHGGRCESGG-GAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLAS 885
Query: 983 EGEDAPFTCSCPTGFEGPTC 1002
G +C+C G+ G C
Sbjct: 886 NGS---HSCTCKVGYTGEDC 902
Score = 57.4 bits (137), Expect = 1e-07
Identities = 58/246 (23%), Positives = 74/246 (30%), Gaps = 67/246 (27%)
Query: 1339 CEPCRKLYCLHGICQPNAT-----PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVP 1393
CE + C G C T C C G+ G HC+ A PC CV+G
Sbjct: 615 CEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEI-APSPCFRSPCVNGGTCE 673
Query: 1394 LDALSYSCQCQDGYSG-------------------------------------------- 1409
+ C CQ GY G
Sbjct: 674 DRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAP 733
Query: 1410 ---ALCNQAGALAEP--------CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-S 1457
+C G +EP CR CLHG G C+C G+ G CE E
Sbjct: 734 SRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERD 793
Query: 1458 ECRGDPVRDFHQVQR--GYAICQTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFEC 1512
ECR P R+ + G +C+ V C +C C G R + + C
Sbjct: 794 ECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLC 853
Query: 1513 SDGTSF 1518
SF
Sbjct: 854 VCPESF 859
Score = 57.0 bits (136), Expect = 1e-07
Identities = 46/169 (27%), Positives = 64/169 (37%), Gaps = 20/169 (11%)
Query: 1340 EPCRKL-YCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS 1398
+PC+ C HGI C C AG+ G C+ A PC +C HG ++ S
Sbjct: 318 QPCQNGGTCTHGINSFR------CQCPAGFGGPTCET-AQSPCDTKECQHGGQCQVENGS 370
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ--- 1455
C CQ GY+GA C + C CL+G C+C F G CE
Sbjct: 371 AVCVCQAGYTGAACEMD---VDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDH 427
Query: 1456 --ESECRGDPVRD---FHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQ 1499
C P + +GY +C+ ++CR P C+
Sbjct: 428 PVPDACLSAPCHNGGTCVDADQGY-VCECPEGFMGLDCRERVPDDCECR 475
Score = 53.1 bits (126), Expect = 2e-06
Identities = 63/236 (26%), Positives = 88/236 (37%), Gaps = 48/236 (20%)
Query: 1324 QDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQ--PADGPC 1381
+ F + + G P + C C +G +A G +C C G++GL C + P D C
Sbjct: 415 EPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCEC 474
Query: 1382 -HGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCR-GLQCLH-GHCQASGTK 1438
+G +C L A + CQC G+ G LC + A PC QC G+C G
Sbjct: 475 RNGGRC-------LGANTTLCQCPLGFFGLLC-EFEITAMPCNMNTQCPDGGYCMEHG-- 524
Query: 1439 GAH-CVC----------------DPGFSGELCE-QESECRGDPVRDFHQVQRGYAICQTT 1480
G++ CVC DP F+G C+ + + R FH C+
Sbjct: 525 GSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKH-----CEKA 579
Query: 1481 RPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAE---EVEKPTKCGCALC 1533
RP C C G K + CS F E+ KP C C
Sbjct: 580 RP-------HLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPC 628
Score = 49.3 bits (116), Expect = 3e-05
Identities = 33/119 (27%), Positives = 43/119 (36%), Gaps = 12/119 (10%)
Query: 1341 PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400
PC C +G C C G+ G HC++ C C +G Y
Sbjct: 544 PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYH 603
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAH-----CVCDPGFSGELCE 1454
C C ++G C + +P C G C GT + C C PGFSG CE
Sbjct: 604 CSCPYRFTGRHCE----IGKPD---SCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCE 655
Score = 47.4 bits (111), Expect = 1e-04
Identities = 38/130 (29%), Positives = 50/130 (38%), Gaps = 16/130 (12%)
Query: 1380 PC-HGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTK 1438
PC +G KC+ CV + SY+C C G++G C+ C C +G G
Sbjct: 277 PCLNGGKCID-DCVTGNP-SYTCSCLSGFTGRRCHLD---VNECASQPCQNGGTCTHGIN 331
Query: 1439 GAHCVCDPGFSGELCE-QESECRGDPVRDFH----QVQRGYAICQTTRPLSWVECR---G 1490
C C GF G CE +S C D H QV+ G A+C + C
Sbjct: 332 SFRCQCPAGFGGPTCETAQSPC--DTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVD 389
Query: 1491 SCPGQGCCQG 1500
C C G
Sbjct: 390 DCSPDPCLNG 399
Score = 41.6 bits (96), Expect = 0.006
Identities = 14/49 (28%), Positives = 27/49 (55%)
Query: 1072 MPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
+P + + +C ++ CQNG C+ +++SC C G+ G+ CE+
Sbjct: 1296 LPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 12/63 (19%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVS-----------LDSCSSGPCENGG 977
C +PCQN GTC + + C C G+KGR CE++ + P GG
Sbjct: 1311 CSENPCQNGGTCVPGA-DAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 978 TCH 980
CH
Sbjct: 1370 VCH 1372
Score = 39.7 bits (91), Expect = 0.023
Identities = 18/36 (50%), Positives = 22/36 (61%), Gaps = 3/36 (8%)
Query: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
+CS PC+NGGTC G DA +C C GF+G C
Sbjct: 1310 NCSENPCQNGGTC--VPGADA-HSCDCGPGFKGRRC 1342
Score = 39.3 bits (90), Expect = 0.030
Identities = 13/34 (38%), Positives = 21/34 (61%)
Query: 1008 DCVDHACANGGVCVDGVGNYTCQCPLQYEGKACE 1041
+C ++ C NGG CV G ++C C ++G+ CE
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 38.5 bits (88), Expect = 0.051
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 1131 CEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWP 1186
C CQNG CV + C C PGF G CE L+ V R F++ + +P
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE--LACIKVSRPCTRLFSETKAFP 1364
Score = 35.8 bits (81), Expect = 0.33
Identities = 13/29 (44%), Positives = 16/29 (55%)
Query: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
NPCQ+ CV D C+C PG+ G C
Sbjct: 1314 NPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 159 bits (401), Expect = 3e-38
Identities = 86/247 (34%), Positives = 112/247 (45%), Gaps = 18/247 (7%)
Query: 886 KEPGIARCAGPQDMEGKL--LLTTPAKKFECQGP--PTLAVQAKCDL-----CLSSPCQN 936
++PG RC +EG L T P C P P+ A C + C +PC N
Sbjct: 232 EQPGECRC-----LEGWTGPLCTVPVSTSSCLSPRGPSSATTG-CLVPGPGPCDGNPCAN 285
Query: 937 QGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTG 996
G+C P + C CP G+ G CEVS +C+ GPC NGG C D+ + C CP G
Sbjct: 286 GGSCSETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPG 344
Query: 997 FEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQH 1056
F+G C D C C NGG+C+D C+C + G CE +D C+ C +
Sbjct: 345 FQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACAN 402
Query: 1057 EAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQ 1116
CV RC C G+ G +C E D C C +G +C + C CA GY G
Sbjct: 403 GGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGA 462
Query: 1117 LCEIPPH 1123
CE P H
Sbjct: 463 RCEFPVH 469
Score = 155 bits (392), Expect = 3e-37
Identities = 93/296 (31%), Positives = 121/296 (40%), Gaps = 52/296 (17%)
Query: 888 PGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSP----CQNQGTCH-- 941
PG+ CA +D EC+ P L +A C SP C+ G C
Sbjct: 202 PGLRPCAPLED--------------ECEAP--LVCRAGC-----SPEHGFCEQPGECRCL 240
Query: 942 --------NDPLEVYRCACPSGYKGRDCEVSLDS---CSSGPCENGGTCHAQEGEDAPFT 990
P+ C P G + C PC NGG+C F
Sbjct: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS---FE 297
Query: 991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV---GNYTCQCPLQYEGKACEQLVDLC 1047
C+CP GF G C V+ C D C NGG+CV G Y C CP ++G CE+ VD C
Sbjct: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357
Query: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
S L PC++ C+ RC C G+AG C + DDC C NG C++ ++ C
Sbjct: 358 S--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
Query: 1108 LCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
CA G+ G+ C PC C +G C + VC C PG+ G CE
Sbjct: 416 SCALGFGGRDCR------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 122 bits (305), Expect = 3e-27
Identities = 73/224 (32%), Positives = 93/224 (41%), Gaps = 27/224 (12%)
Query: 960 DCEVSL---DSCSS--GPCENGGTCHAQEGEDAPF--------TCSCPTGFEGPTCGV-- 1004
+CE L CS G CE G C EG P +C P G T G
Sbjct: 213 ECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
Query: 1005 -NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGT 1063
C + CANGG C + ++ C CP + G CE C+ PC + CVG
Sbjct: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFNGGLCVGG 330
Query: 1064 PDGPR---CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
D C C PG+ G NC + D C C+NG C+D ++ C C G++G CE
Sbjct: 331 ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE- 389
Query: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
C G C NG CV+ G C C GFGG +C +
Sbjct: 390 -----HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 62.4 bits (150), Expect = 3e-09
Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 46/230 (20%)
Query: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD------------------- 1378
GC P HG C+ PG C C GW G C P
Sbjct: 223 GCSP------EHGFCEQ---PGE-CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
Query: 1379 ---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAE--PC-RGLQCLHGHC 1432
GPC G+ C +G S+ C C G+ G C +G PC G C+ G
Sbjct: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG-- 330
Query: 1433 QASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQ-VQRGYAI-CQTTRPLSWVECR 1489
A C C PGF G CE+ C P R+ + G+A+ C+ + C
Sbjct: 331 -ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
Query: 1490 ---GSCPGQGCCQGLRLKRRKFTFECSDGTSFA--EEVEKPTKCGCALCA 1534
C G+ C G CS F + E+ C CA
Sbjct: 390 HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
Score = 61.2 bits (147), Expect = 7e-09
Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 9/115 (7%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+PCR G+C + C C AG+ G C+ D C G C +G ++
Sbjct: 360 QPCRN----GGLCL-DLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAH 413
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
C C G+ G C + A+PC C HG + G C C PG+ G CE
Sbjct: 414 RCSCALGFGGRDCRER---ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 159 bits (401), Expect = 3e-38
Identities = 86/247 (34%), Positives = 112/247 (45%), Gaps = 18/247 (7%)
Query: 886 KEPGIARCAGPQDMEGKL--LLTTPAKKFECQGP--PTLAVQAKCDL-----CLSSPCQN 936
++PG RC +EG L T P C P P+ A C + C +PC N
Sbjct: 232 EQPGECRC-----LEGWTGPLCTVPVSTSSCLSPRGPSSATTG-CLVPGPGPCDGNPCAN 285
Query: 937 QGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTG 996
G+C P + C CP G+ G CEVS +C+ GPC NGG C D+ + C CP G
Sbjct: 286 GGSCSETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPG 344
Query: 997 FEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQH 1056
F+G C D C C NGG+C+D C+C + G CE +D C+ C +
Sbjct: 345 FQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACAN 402
Query: 1057 EAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQ 1116
CV RC C G+ G +C E D C C +G +C + C CA GY G
Sbjct: 403 GGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGA 462
Query: 1117 LCEIPPH 1123
CE P H
Sbjct: 463 RCEFPVH 469
Score = 155 bits (392), Expect = 3e-37
Identities = 93/296 (31%), Positives = 121/296 (40%), Gaps = 52/296 (17%)
Query: 888 PGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSP----CQNQGTCH-- 941
PG+ CA +D EC+ P L +A C SP C+ G C
Sbjct: 202 PGLRPCAPLED--------------ECEAP--LVCRAGC-----SPEHGFCEQPGECRCL 240
Query: 942 --------NDPLEVYRCACPSGYKGRDCEVSLDS---CSSGPCENGGTCHAQEGEDAPFT 990
P+ C P G + C PC NGG+C F
Sbjct: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS---FE 297
Query: 991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV---GNYTCQCPLQYEGKACEQLVDLC 1047
C+CP GF G C V+ C D C NGG+CV G Y C CP ++G CE+ VD C
Sbjct: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357
Query: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
S L PC++ C+ RC C G+AG C + DDC C NG C++ ++ C
Sbjct: 358 S--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
Query: 1108 LCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
CA G+ G+ C PC C +G C + VC C PG+ G CE
Sbjct: 416 SCALGFGGRDCR------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 122 bits (305), Expect = 3e-27
Identities = 73/224 (32%), Positives = 93/224 (41%), Gaps = 27/224 (12%)
Query: 960 DCEVSL---DSCSS--GPCENGGTCHAQEGEDAPF--------TCSCPTGFEGPTCGV-- 1004
+CE L CS G CE G C EG P +C P G T G
Sbjct: 213 ECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
Query: 1005 -NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGT 1063
C + CANGG C + ++ C CP + G CE C+ PC + CVG
Sbjct: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFNGGLCVGG 330
Query: 1064 PDGPR---CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
D C C PG+ G NC + D C C+NG C+D ++ C C G++G CE
Sbjct: 331 ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE- 389
Query: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
C G C NG CV+ G C C GFGG +C +
Sbjct: 390 -----HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 62.4 bits (150), Expect = 3e-09
Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 46/230 (20%)
Query: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD------------------- 1378
GC P HG C+ PG C C GW G C P
Sbjct: 223 GCSP------EHGFCEQ---PGE-CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
Query: 1379 ---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAE--PC-RGLQCLHGHC 1432
GPC G+ C +G S+ C C G+ G C +G PC G C+ G
Sbjct: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG-- 330
Query: 1433 QASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQ-VQRGYAI-CQTTRPLSWVECR 1489
A C C PGF G CE+ C P R+ + G+A+ C+ + C
Sbjct: 331 -ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
Query: 1490 ---GSCPGQGCCQGLRLKRRKFTFECSDGTSFA--EEVEKPTKCGCALCA 1534
C G+ C G CS F + E+ C CA
Sbjct: 390 HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
Score = 61.2 bits (147), Expect = 7e-09
Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 9/115 (7%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+PCR G+C + C C AG+ G C+ D C G C +G ++
Sbjct: 360 QPCRN----GGLCL-DLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAH 413
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
C C G+ G C + A+PC C HG + G C C PG+ G CE
Sbjct: 414 RCSCALGFGGRDCRER---ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 157 bits (397), Expect = 7e-38
Identities = 118/430 (27%), Positives = 200/430 (46%), Gaps = 26/430 (6%)
Query: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
CP C C V C + L +P ++P I ++ AF L ++
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
Query: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
N Q+ + PDAF GL L L + G+ +L +F L +L L LN N + + F
Sbjct: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461
Q L L L L N++Q+L + F L ++TL+LAQN L L + L +P+ +
Sbjct: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL------LAQLPEEL-FHPLTS 194
Query: 462 SGARCASPRRLANKRIGQIKSKKF-RCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCE 520
+L+N + + F + + ++ F+ +L + S + C + +
Sbjct: 195 -----LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQ 249
Query: 521 ANVVECSSLKLTKIPERIPQSTAELR---LNNNEISILEATGMFKKLTHLKKINLSNNKV 577
N + T +P I S L L N + +L A G+F L ++L++N++
Sbjct: 250 RNAI-------THLPLSIFASLGNLTFLSLQWNMLRVLPA-GLFAHTPCLVGLSLTHNQL 301
Query: 578 SEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLR 637
+ +G F +++ L L+ N + + +G+FR L+ L L L +N ++ +H F L
Sbjct: 302 ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLS 361
Query: 638 NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK--RKIVTGN 695
+ LLSL NQ+TT+ G FDT +L L L NP+ C+C LA+L WL++ +++
Sbjct: 362 KLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ 421
Query: 696 PRCQNPDFLR 705
C P +L+
Sbjct: 422 TYCAGPAYLK 431
Score = 152 bits (385), Expect = 2e-36
Identities = 129/476 (27%), Positives = 207/476 (43%), Gaps = 37/476 (7%)
Query: 16 PELWLLLWAAAWRLG--ASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNI 73
P WLL W + L A CP C C V C L +P +IP T+ + +
Sbjct: 3 PGAWLL-WTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSF 61
Query: 74 TRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQ 133
T + F L + + Q+ AF + LE L + + L +F N
Sbjct: 62 TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLT 121
Query: 134 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
+L +L L+ N ++A+P F+ L++L L NQ+ + F+ L L+ L L N +
Sbjct: 122 SLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
Query: 194 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNV 253
+P F+ + L+T +L +N L + L Q G+F + SL+ L +
Sbjct: 182 AQLPEELFHPLTSLQTLKLSNNAL------SGLPQ--------GVFGKLG---SLQELFL 224
Query: 254 AEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
SE +P S C + + A NL T
Sbjct: 225 DSNNISE-----------LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL----TF 269
Query: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
+ L+ N ++ +P G F+ L + L++NQ+ +A F L +L SL+L N IT LP
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Query: 374 RGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQT 433
G+F L L L L +N + + P FQ+L L LLSL N++ +L +G F + +
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
Query: 434 LHLAQNPFICDCNLKWLADFLR--TNPIETSGARCASPRRLANKRIGQIKSKKFRC 487
L L NP+ CDC+L +L ++L+ T+ + CA P L + + + K+ C
Sbjct: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
Score = 126 bits (317), Expect = 1e-28
Identities = 118/437 (27%), Positives = 186/437 (42%), Gaps = 48/437 (10%)
Query: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572
CP C C V CS +L +P IP T + + LE T F +L K+
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE-TRAFGSNPNLTKVVF 80
Query: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDS 632
N ++ + AF G + +L +T + ++ + +F L L L L N + +
Sbjct: 81 LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 633 FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN-----PFNCNCQLAWLGGWLR 687
F L + L L NQ+ + F L L TLNL N P L L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKL 200
Query: 688 KRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTV--V 745
++G P+ F + LQ++ E LP PQ + CL+ +
Sbjct: 201 SNNALSGLPQGV---FGKLGSLQELFLDSNNISE-------LP-PQVFSQLFCLERLWLQ 249
Query: 746 RCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSF 804
R + HL N+T L L N ++P G + L + L++N++ +++ +F
Sbjct: 250 RNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTF 309
Query: 805 TNMSQLTTLILSYNALQCIP------------------------PLAFQGLRSLRLLSLH 840
++S L +L+LSYNA+ +P P FQ L L LLSL
Sbjct: 310 AHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369
Query: 841 GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGI---ARCAGPQ 897
N ++TL EGIF +L +LA+ NP CDCHL +L +W++ Y + + CAGP
Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQ-YTDRLLNIQTYCAGPA 428
Query: 898 DMEGKLLLTTPAKKFEC 914
++G+++ K+ C
Sbjct: 429 YLKGQVVPALNEKQLVC 445
Score = 60.8 bits (146), Expect = 1e-08
Identities = 41/164 (25%), Positives = 66/164 (40%), Gaps = 25/164 (15%)
Query: 730 PRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV------------- 776
P CP C C V CS++ L +P IP + FT +
Sbjct: 18 PAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
Query: 777 ------------PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
P L+ ++++ + +LS + F+N++ L L L++N L+ +P
Sbjct: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALP 137
Query: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
FQ L +L L L GN + L +F +T L L + N L
Sbjct: 138 EGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 156 bits (395), Expect = 1e-37
Identities = 131/412 (31%), Positives = 190/412 (46%), Gaps = 36/412 (8%)
Query: 513 CPHKCRC--EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570
CP +C C + V C+ +LT +P+ IP T L L+ N I L G L L+++
Sbjct: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP-GDLAALPALEEL 83
Query: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
+LS N ++ +E GAF + L L NQL+ I G+F LD L L L N++ + +
Sbjct: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
Query: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRK 690
+F L ++R L + DN + VS AF L +L L L C L L G
Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE------RCNLTALSGES---- 193
Query: 691 IVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNK 750
G+ R LR + + + +FR G L P L+ V S
Sbjct: 194 --LGHLRSLGALRLRHLAIASLEDQNFRRLPGLLH---LEIDNWP----LLEEVAAGS-- 242
Query: 751 HLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLSNSSFTNMSQ 809
LR L N+T L + T VP L +L ++LS+N IS++ SF ++ +
Sbjct: 243 -LRGL------NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR 295
Query: 810 LTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLY 869
L L L+ L + P AF GLR +RLL+L N +STL+E F V +L L + NPL
Sbjct: 296 LRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
Query: 870 CDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTP----AKKFECQGP 917
CDC L W+ KT + + CA P ++ G L P + F C+ P
Sbjct: 356 CDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKP 407
Score = 143 bits (360), Expect = 1e-33
Identities = 128/461 (27%), Positives = 197/461 (42%), Gaps = 80/461 (17%)
Query: 272 VPTCTLSSGSCPAMCTCS--NGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAF 329
+P +G CPA C C+ V C + LTA+P +P + L N I+ + PG
Sbjct: 15 LPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDL 74
Query: 330 SPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389
+ L +DLS N IA + P AF L L L L GN++ +P GVF L L LL L+
Sbjct: 75 AALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLS 134
Query: 390 ANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKW 449
NK+ + FQDL +L L + DN + +++ F L A++ L L + CNL
Sbjct: 135 ENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLER------CNLTA 188
Query: 450 LADFLRTNPIETSG-ARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECN 508
L+ E+ G R RL + I ++ + FR +PG ++++
Sbjct: 189 LSG-------ESLGHLRSLGALRLRHLAIASLEDQNFR-------RLPGLLHLEIDNWPL 234
Query: 509 SDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
+ V R L LT L + + I+ + A + + HL
Sbjct: 235 LEEVAAGSLR---------GLNLT-----------SLSVTHTNITAVPAAAL-RHQAHLT 273
Query: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
+NLS+N +S + G+F + ELHL L + F GL +R L L NN +S
Sbjct: 274 CLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLS-- 331
Query: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688
T+ F ++ +L TL + NP C+C+L W+ +++
Sbjct: 332 ----------------------TLEESTFHSVNTLETLRVDGNPLACDCRLLWI---VQR 366
Query: 689 RKIVTGN---PRCQNP-----DFLRQIPLQDVAFPDFRCEE 721
RK + + P C P D LR +P V F F C +
Sbjct: 367 RKTLNFDGRLPACATPAEVRGDALRNLP-DSVLFEYFVCRK 406
Score = 142 bits (359), Expect = 2e-33
Identities = 117/377 (31%), Positives = 162/377 (42%), Gaps = 54/377 (14%)
Query: 31 ASACPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLR 88
A CPA C CT T V C L A+P IP T LEL+ N I ++ D A L L
Sbjct: 22 AGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALE 81
Query: 89 VLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAI 148
L L EN I VE GAF ++ L LRL NQL ++P +F L+ LDLSEN + +
Sbjct: 82 ELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVIL 141
Query: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLR 208
F+ L+ L++ N + + AF L LE LTL N+T + S H+ L
Sbjct: 142 LDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLG 201
Query: 209 TFRLHSNHLFCDCHLAWLS---QWLRQRPTIGLFTQCSGP-------ASLRGLNVAEVQK 258
RL HLA S Q R+ P + + P SLRGLN+ +
Sbjct: 202 ALRLR--------HLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSV 253
Query: 259 SEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLEL 318
+ + + VP L A TC N L
Sbjct: 254 THTNITA------VPAAALRH---QAHLTCLN-------------------------LSH 279
Query: 319 NGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFG 378
N I ++P G+F +LR + L+ +A + P AF GLR + L L N ++ L F
Sbjct: 280 NPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFH 339
Query: 379 GLYTLQLLLLNANKINC 395
+ TL+ L ++ N + C
Sbjct: 340 SVNTLETLRVDGNPLAC 356
Score = 83.2 bits (204), Expect = 2e-15
Identities = 59/211 (27%), Positives = 93/211 (44%), Gaps = 24/211 (11%)
Query: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAF-----------DDMKELE 112
E L L N+T + L+ L L+L I ++E F D+ LE
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 113 R-------------LRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDL 159
L + + +P ++ L+ L+LS N I +PR +FR L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
Query: 160 KNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFC 219
+ L L ++ +E AF LR + +L L+NN ++T+ S+F+ + L T R+ N L C
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLAC 356
Query: 220 DCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250
DC L W+ Q + G C+ PA +RG
Sbjct: 357 DCRLLWIVQRRKTLNFDGRLPACATPAEVRG 387
Score = 81.3 bits (199), Expect = 7e-15
Identities = 52/142 (36%), Positives = 70/142 (49%), Gaps = 3/142 (2%)
Query: 730 PRPQCPQECACL--DTVVRCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYL 786
P CP C C V C+ + L A+P GIP L L N+ L PG L+ L
Sbjct: 21 PAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPAL 80
Query: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
+ +DLS N I+ + +F N+ +L L L N L+ IPP F L +L LL L N +
Sbjct: 81 EELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVI 140
Query: 847 LQEGIFADVTSLSHLAIGANPL 868
L + F D+ SL L +G N L
Sbjct: 141 LLDYTFQDLHSLRRLEVGDNDL 162
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 152 bits (385), Expect = 2e-36
Identities = 116/450 (25%), Positives = 185/450 (41%), Gaps = 88/450 (19%)
Query: 963 VSLDSCSSGPCENGGTCHAQEGEDA-------------------PFTCSCPTGFEGPTCG 1003
V DSC GPC+NGG+C + + PF C C G+ G C
Sbjct: 3801 VDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCE 3860
Query: 1004 VNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGT 1063
++ D+C+ C +GG C + VG ++C CP + G+ACE+ ++ C +PC++ A C
Sbjct: 3861 IDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQ--SPCKNGAICQNF 3918
Query: 1064 PDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPH 1123
P C C GY G C + + C + C NG C V+SY C C G G+ CE+ +
Sbjct: 3919 PGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNSY 3978
Query: 1124 LPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQ 1183
GF E+L +Y++F L
Sbjct: 3979 --------------------------------GF-----EEL---------SYMEFPSLD 3992
Query: 1184 NWPRAN-ITLQVSTAEDNGILLYNGDN------DHIAVELYQGHVRVSYDPGSYPSSAIY 1236
P N I ++ +T + + +LLYN DN + +A+E+ + +R SY+ GS + +
Sbjct: 3993 --PNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGS-GTYKLT 4049
Query: 1237 SAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNS 1296
+ + ++DG FHTV +L++D S + + + P V
Sbjct: 4050 TMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTV 4109
Query: 1297 AAFR-LWQILNGTG------FHGCIRNLYINNELQDFTKTQMKPGVVPGCE----PCRKL 1345
R L IL G F GCI +N + ++ G++ C C +
Sbjct: 4110 GGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRS 4169
Query: 1346 YCLHGICQPNATPGPMCHCEAGWVGLHCDQ 1375
C HG + CHC+ G G +C++
Sbjct: 4170 PCQHGGTCMDYWSWQQCHCKEGLTGKYCEK 4199
Score = 131 bits (329), Expect = 6e-30
Identities = 63/178 (35%), Positives = 84/178 (47%), Gaps = 26/178 (14%)
Query: 927 DLCLSSPCQNQGTC---------------------HNDPLEVYRCACPSGYKGRDCEVSL 965
D C+ PCQN G+C N+PL+ + C C GY G CE+ +
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 966 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVG 1025
D C PC +GGTCH G F+CSCP GF G C + ++C+ C NG +C + G
Sbjct: 3864 DECLPSPCHSGGTCHNLVGG---FSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPG 3920
Query: 1026 NYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN 1083
++ C C Y GK CE V+ C + NPC + C D C C G G +C N
Sbjct: 3921 SFNCVCKTGYTGKMCESSVNYC--ECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELN 3976
Score = 74.3 bits (181), Expect = 8e-13
Identities = 46/143 (32%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 867 PLYCDCHLRWLSSWVKTGYKE--PGIARCAGP-QDMEGKLLLTTPAKKFECQGPPTLAVQ 923
P C C + SW + E P G ++ G + P G A +
Sbjct: 3845 PFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCP------DGFTGRACE 3898
Query: 924 AKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQE 983
+ CL SPC+N C N P + C C +GY G+ CE S++ C PC NGG+C Q
Sbjct: 3899 RDINECLQSPCKNGAICQNFPGS-FNCVCKTGYTGKMCESSVNYCECNPCFNGGSC--QS 3955
Query: 984 GEDAPFTCSCPTGFEGPTCGVNT 1006
G D+ + C CP G G C +N+
Sbjct: 3956 GVDS-YYCHCPFGVFGKHCELNS 3977
Score = 64.3 bits (155), Expect = 9e-10
Identities = 40/118 (33%), Positives = 52/118 (44%), Gaps = 25/118 (21%)
Query: 906 TTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
T P+ K C+GP ++C S+PC C N YRC P
Sbjct: 4390 TDPSVKIGCRGP---------NICASNPCWGDLLCINQ-WYAYRCVPPG----------- 4428
Query: 966 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDG 1023
C+S PC+NGG+C + G + FTCSCP G TC + C+ C G VC G
Sbjct: 4429 -DCASHPCQNGGSC--EPGLHSGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAG 4482
Score = 53.5 bits (127), Expect = 2e-06
Identities = 73/361 (20%), Positives = 121/361 (33%), Gaps = 74/361 (20%)
Query: 1125 PAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK------LLSVNFVDRDTY-- 1176
P + C + CQ+G C+D + C C G G CEK LS+ R Y
Sbjct: 4160 PRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHM 4219
Query: 1177 -------------LQFTDLQNWPRANITLQVSTAEDNGILLY-NGDNDHIAVELYQGHVR 1222
L+ L+ + ++ ++ T +NG+L++ +++ V++ G V
Sbjct: 4220 SQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVY 4279
Query: 1223 VSYDPGSYPSSAIYSAET-INDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNS 1281
+ D G E + DG +HT + LS+D + + + +
Sbjct: 4280 FTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLD 4339
Query: 1282 EAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEP 1341
+ +GG+P + + + GF GCI +++ E F+ + +P
Sbjct: 4340 VLTISLGGIPPN------QAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISK-TDP 4392
Query: 1342 CRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400
K+ C IC N G + C W C P D C H C +G
Sbjct: 4393 SVKIGCRGPNICASNPCWGDLL-CINQWYAYRCVPPGD--CASHPCQNG----------- 4438
Query: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECR 1460
G C+ G C C +G CE C
Sbjct: 4439 -----------------------------GSCEPGLHSGFTCSCPDSHTGRTCEMVVACL 4469
Query: 1461 G 1461
G
Sbjct: 4470 G 4470
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 4/118 (3%)
Query: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
+ C C G N G C C G+ G C++ + C C +G S+
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDIN-ECLQSPCKNGAICQNFPGSF 3922
Query: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES 1457
+C C+ GY+G +C + C C +G SG +C C G G+ CE S
Sbjct: 3923 NCVCKTGYTGKMCESS---VNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNS 3977
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/68 (38%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 1008 DCVDHACANGGVCVDGV-GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDG 1066
DC H C NGG C G+ +TC CP + G+ CE +V C L P Q + G+P G
Sbjct: 4429 DCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVV-ACLGVLCP-QGKVCKAGSPAG 4486
Query: 1067 PRCECMPG 1074
C G
Sbjct: 4487 HVCVLSQG 4494
Score = 43.9 bits (102), Expect = 0.001
Identities = 27/92 (29%), Positives = 38/92 (41%), Gaps = 20/92 (21%)
Query: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS-YSCLCA 1110
NPC + C+ RC PG DC H CQNG C ++S ++C C
Sbjct: 4407 NPCWGDLLCINQWYAYRC-VPPG-----------DCASHPCQNGGSCEPGLHSGFTCSCP 4454
Query: 1111 EGYSGQLCEIPPHLPAPKSPCEGTECQNGANC 1142
+ ++G+ CE+ C G C G C
Sbjct: 4455 DSHTGRTCEM-------VVACLGVLCPQGKVC 4479
Score = 40.4 bits (93), Expect = 0.013
Identities = 31/120 (25%), Positives = 49/120 (40%), Gaps = 25/120 (20%)
Query: 1399 YSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGT-----KGAHCVCDPGFSGELC 1453
+ C+C GY+G+ C +CL C + GT G C C GF+G C
Sbjct: 3846 FLCKCLPGYAGSWCE--------IDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRAC 3897
Query: 1454 EQE-SECRGDPVRD----------FHQV-QRGYAICQTTRPLSWVECRGSCPGQGCCQGL 1501
E++ +EC P ++ F+ V + GY +++ EC G C G+
Sbjct: 3898 ERDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGV 3957
Score = 33.9 bits (76), Expect = 1.2
Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
C SPCQ+ GTC D +C C G G+ CE S+
Sbjct: 4166 CTRSPCQHGGTC-MDYWSWQQCHCKEGLTGKYCEKSV 4201
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 150 bits (378), Expect = 1e-35
Identities = 138/535 (25%), Positives = 214/535 (40%), Gaps = 85/535 (15%)
Query: 33 ACPALCTCT---GTT-VDCHGTGLQAIPKNI--PRNTERLELNGNNITRIHKNDFAGLKQ 86
+C +LC C GT ++C G++ + + P +L L N +T +H NDF+GL
Sbjct: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89
Query: 87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146
+ L N I +E GAF+ + L++L +N N L +L E F + L L N I
Sbjct: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
Query: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF-NHMP 205
I AF LK L L+ N I + FR + L L L N + T+P F H+
Sbjct: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIG 208
Query: 206 KLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLNVAEVQKSEF-- 261
++ +L N C+C L L WL P + C+ P +G ++ ++K
Sbjct: 209 RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICP 268
Query: 262 ------------------SCSGQGEA-----------------GRVPTCT-----LSSGS 281
+ S ++ G +P T L
Sbjct: 269 TPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPY 328
Query: 282 CPAMCTC-----SNGIVDCRGKGLTAIPANLPETMTEIRLELNG--IKSIPPGAFSPYRK 334
CP C C S ++ C+ + + ++ P +L L G I S+ Y
Sbjct: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
Query: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
L + L NN+I + +F L L L L GN +T L +G+F GL+ L+ L L N I
Sbjct: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
Query: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFT-------SLRAIQTLH------------ 435
I P F + L +L L +N +Q L F+ +L+ Q H
Sbjct: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDL 508
Query: 436 -----LAQNPFICDCNLKWLADFLR--TNPIETSGARCASPRRLANKRIGQIKSK 483
L NP+ C C+L L +++ + T C SP L K + + S+
Sbjct: 509 LTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSE 563
Score = 132 bits (333), Expect = 2e-30
Identities = 143/596 (23%), Positives = 229/596 (38%), Gaps = 113/596 (18%)
Query: 278 SSGSCPAMCTCSNG----IVDCRGKGLTAIP--ANLPETMTEIRLELNGIKSIPPGAFSP 331
S GSC ++C C +++C KG+ + + P ++ L NG+ + FS
Sbjct: 27 SRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSG 86
Query: 332 YRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNAN 391
I L N IA+I AF GL L L + N + L F GL L+ L + N
Sbjct: 87 LTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Query: 392 KINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSL---------RAIQTL-------- 434
I I P AF L L +L L DN I+SL F + +QTL
Sbjct: 147 FITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEH 206
Query: 435 -------HLAQNPFICDCNLKWLADFLRTNPIET--SGARCASPRRLANKRIGQIKSKKF 485
L N + C+C+L L +L P ++ C SP + ++K +
Sbjct: 207 IGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESI 266
Query: 486 ----------------------------RCSAKEQYFI------PGTEDYQLNSECN-SD 510
R S K + PG Y
Sbjct: 267 CPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPG 326
Query: 511 VVCPHKCRCEAN-----VVECSSLKLTKIPERIP--QSTAELRLNNNEISILEATGMFKK 563
CP C C+ ++ C + + + P Q+ +L L N I L + + +
Sbjct: 327 PYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEY 386
Query: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
T L+ ++L NN++ +E+G+F + +L+L N L + GMF GL L L L N
Sbjct: 387 FT-LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYN 445
Query: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------------------DT 659
I I +F + +++L L +N + + P F D
Sbjct: 446 AIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDD 505
Query: 660 LQSLSTLNLLANPFNCNCQLAWLGGWLRK--RKIVTGNPRCQNPDFLRQIPLQDVAFPDF 717
L L+ ++L NP++C+C L L W++K + VT + C +P L + L+ + +
Sbjct: 506 LDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN-SEI 564
Query: 718 RCEEGQEEGGCLPRPQCPQECACL-----DTVVRCSNKHLRALPKGIPKNVTELYL 768
C G + P P + + L T ++ LR+L +P +V L L
Sbjct: 565 LCP------GLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGL 614
Score = 122 bits (307), Expect = 2e-27
Identities = 115/442 (26%), Positives = 182/442 (41%), Gaps = 87/442 (19%)
Query: 513 CPHKCRCEAN----VVECSSLKLTKIPE-RIPQSTA-ELRLNNNEISILEATGMFKKLTH 566
C C CE ++ C + + + E +P S +L L NN +++L T F LT+
Sbjct: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH-TNDFSGLTN 89
Query: 567 LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRIS 626
I+L N +++IE GAF G + +LH+ N LE ++ F GL+ L L NN I+
Sbjct: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
Query: 627 CIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------DTLQSLS---------- 664
I +F+ L +++L L DN I ++ P F + LQ+L
Sbjct: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR 209
Query: 665 --TLNLLANPFNCNCQLAWLGGWLRKR--KIVTGNPRCQNPDF-----LRQIPLQDVAFP 715
L L N + CNC L L WL + + G+ C +P F L ++ + +
Sbjct: 210 ILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPT 269
Query: 716 DFRCEEGQEEGGC-----------------------------------------LPRPQC 734
EE ++ G LP P C
Sbjct: 270 PPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYC 329
Query: 735 PQECAC-----LDTVVRCSNKHLRALP--KGIPKNVTELYLDGNQF-TLVPGQLSTFKYL 786
P C C ++ C +++ +L + P+N +L L GN +L+ L + L
Sbjct: 330 PIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTL 389
Query: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
+++ L NN+I L SF N+++L L L+ N L + F GL +L L L N I
Sbjct: 390 EMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
Query: 847 LQEGIFADVTSLSHLAIGANPL 868
+ G F + L L + N L
Sbjct: 450 ILPGTFNPMPKLKVLYLNNNLL 471
Score = 87.4 bits (215), Expect = 9e-17
Identities = 72/253 (28%), Positives = 112/253 (44%), Gaps = 12/253 (4%)
Query: 34 CPALCTC-----TGTTVDCHGTGLQAIP--KNIPRNTERLELNGNNITRIHKNDFAGLKQ 86
CP C C +G + C ++++ + P+N +L L GN I + K+D
Sbjct: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
Query: 87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146
L +L L N+I +E G+F ++ L++L LN N L L + +F L L L NAI+
Sbjct: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
Query: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS-FNHMP 205
I F LK L L+ N + + F + L + L N T +PVS+ + +
Sbjct: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLD 507
Query: 206 KLRTFRLHSNHLFCDCHLAWLSQWLRQ--RPTIGLFTQCSGPASLRGLNVAEVQKSEFSC 263
L L N C C L L QW+++ + T+ C+ P L + + SE C
Sbjct: 508 LLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKEL-KALNSEILC 566
Query: 264 SGQGEAGRVPTCT 276
G +PT T
Sbjct: 567 PGLVNNPSMPTQT 579
Score = 54.7 bits (130), Expect = 7e-07
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
L+ + NN I+ + S+F+ +++L LIL+ NA++ +PP F+ + L L L GN +
Sbjct: 138 LEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQ 196
Query: 846 TL-QEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEP--GIARCAGPQDMEGK 902
TL G + + L + N C+C L L +W++ + G C P +G
Sbjct: 197 TLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGS 256
Query: 903 LLLTTPAKKFECQGPP 918
+L+ K+ C PP
Sbjct: 257 -ILSRLKKESICPTPP 271
Score = 39.7 bits (91), Expect = 0.023
Identities = 31/145 (21%), Positives = 60/145 (41%), Gaps = 7/145 (4%)
Query: 731 RPQCPQECACLDT----VVRCSNKHLRALPKGI--PKNVTELYLDGNQFTLV-PGQLSTF 783
R C C C + ++ C K ++ + + P +L L N T++ S
Sbjct: 28 RGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGL 87
Query: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843
+ L N I+ + +F + L L +++N+L+ + F GL +L L N
Sbjct: 88 TNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNF 147
Query: 844 ISTLQEGIFADVTSLSHLAIGANPL 868
I+ ++ F+ + L L + N +
Sbjct: 148 ITVIEPSAFSKLNRLKVLILNDNAI 172
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 148 bits (373), Expect = 5e-35
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 27/258 (10%)
Query: 916 GPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCEN 975
G P V+A D C S G C D C C G++G CE C P
Sbjct: 18 GAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMPGCQ 67
Query: 976 GGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCV-DGVGNYTCQCPL 1033
GTCH P+ C C +G+ G C + C + C NGG C+ DG G Y C C
Sbjct: 68 HGTCHQ------PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
Query: 1034 QYEGKACEQLVDLCSPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDH 1090
+ G+ CE+ C +PC++ QC G C C+ G+ G C N DDC
Sbjct: 122 GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMR 181
Query: 1091 RCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV 1150
C NGA C+D +N +SCLC EG++G+ C I C CQ GA C D+ +
Sbjct: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTI------NLDDCASRPCQRGARCRDRVHDFD 235
Query: 1151 CQCLPGFGGPECEKLLSV 1168
C C G+GG CE +L V
Sbjct: 236 CLCPSGYGGKTCELVLPV 253
Score = 148 bits (373), Expect = 5e-35
Identities = 78/211 (36%), Positives = 106/211 (50%), Gaps = 16/211 (7%)
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS-GPCENGGTCHAQEG 984
C+ C+ P GTCH + ++C C SG+ G+ C+ C++ PC+NGG C G
Sbjct: 57 CERCVRMPGCQHGTCH----QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDC--VDHACANGGVCVDGVG---NYTCQCPLQYEGKA 1039
+ + C C GF G C C C NGG C D G N+TC+C + + G
Sbjct: 113 GE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
Query: 1040 CEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM 1099
CE VD C + PC + A C+ + C C G+AG C+ N DDC CQ GA+C
Sbjct: 171 CEVNVDDCL--MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 1100 DEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
D V+ + CLC GY G+ CE+ LP P P
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV--LPVPDPP 257
Score = 75.5 bits (184), Expect = 4e-13
Identities = 48/143 (33%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYS 1408
HG C P+ + C C+ GW GLHC++ P C HG C + C C G++
Sbjct: 37 HGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGWA 84
Query: 1409 GALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES---ECRGD 1462
G C++ + PC+ G C G HCVC PGF G CE+++ E G
Sbjct: 85 GKFCDKDEHICTTQSPCQN----GGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
Query: 1463 PVRDFHQVQ--RGYAICQTTRPL 1483
P R+ Q Q +G+A+ T R L
Sbjct: 141 PCRNGGQCQDDQGFALNFTCRCL 163
Score = 52.0 bits (123), Expect = 4e-06
Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 28/126 (22%)
Query: 1362 CHCEAGWVGLHCDQPADGPCH--GHKCVHG-QCVPLD--ALSYSCQCQDGYSGALC--NQ 1414
C C G+ G C++ A GPC G C +G QC AL+++C+C G+ GA C N
Sbjct: 117 CVCLPGFHGRDCERKA-GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
Query: 1415 AGALAEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGEL------------CEQESECRG 1461
L PC G CL G + S C+C GF+G C++ + CR
Sbjct: 176 DDCLMRPCANGATCLDGINRFS------CLCPEGFAGRFCTINLDDCASRPCQRGARCR- 228
Query: 1462 DPVRDF 1467
D V DF
Sbjct: 229 DRVHDF 234
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 12/97 (12%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS-YSCQCQDGYSGALC--NQAGAL 1418
C C G+VG C+ D C C +G LD ++ +SC C +G++G C N
Sbjct: 160 CRCLVGFVGARCEVNVDD-CLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCA 217
Query: 1419 AEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
+ PC RG +C C+C G+ G+ CE
Sbjct: 218 SRPCQRGARC------RDRVHDFDCLCPSGYGGKTCE 248
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 148 bits (373), Expect = 5e-35
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 27/258 (10%)
Query: 916 GPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCEN 975
G P V+A D C S G C D C C G++G CE C P
Sbjct: 18 GAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMPGCQ 67
Query: 976 GGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCV-DGVGNYTCQCPL 1033
GTCH P+ C C +G+ G C + C + C NGG C+ DG G Y C C
Sbjct: 68 HGTCHQ------PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
Query: 1034 QYEGKACEQLVDLCSPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDH 1090
+ G+ CE+ C +PC++ QC G C C+ G+ G C N DDC
Sbjct: 122 GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMR 181
Query: 1091 RCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV 1150
C NGA C+D +N +SCLC EG++G+ C I C CQ GA C D+ +
Sbjct: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTI------NLDDCASRPCQRGARCRDRVHDFD 235
Query: 1151 CQCLPGFGGPECEKLLSV 1168
C C G+GG CE +L V
Sbjct: 236 CLCPSGYGGKTCELVLPV 253
Score = 148 bits (373), Expect = 5e-35
Identities = 78/211 (36%), Positives = 106/211 (50%), Gaps = 16/211 (7%)
Query: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS-GPCENGGTCHAQEG 984
C+ C+ P GTCH + ++C C SG+ G+ C+ C++ PC+NGG C G
Sbjct: 57 CERCVRMPGCQHGTCH----QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 985 EDAPFTCSCPTGFEGPTCGVNTDDC--VDHACANGGVCVDGVG---NYTCQCPLQYEGKA 1039
+ + C C GF G C C C NGG C D G N+TC+C + + G
Sbjct: 113 GE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
Query: 1040 CEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM 1099
CE VD C + PC + A C+ + C C G+AG C+ N DDC CQ GA+C
Sbjct: 171 CEVNVDDCL--MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 1100 DEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
D V+ + CLC GY G+ CE+ LP P P
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV--LPVPDPP 257
Score = 75.5 bits (184), Expect = 4e-13
Identities = 48/143 (33%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYS 1408
HG C P+ + C C+ GW GLHC++ P C HG C + C C G++
Sbjct: 37 HGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGWA 84
Query: 1409 GALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES---ECRGD 1462
G C++ + PC+ G C G HCVC PGF G CE+++ E G
Sbjct: 85 GKFCDKDEHICTTQSPCQN----GGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
Query: 1463 PVRDFHQVQ--RGYAICQTTRPL 1483
P R+ Q Q +G+A+ T R L
Sbjct: 141 PCRNGGQCQDDQGFALNFTCRCL 163
Score = 52.0 bits (123), Expect = 4e-06
Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 28/126 (22%)
Query: 1362 CHCEAGWVGLHCDQPADGPCH--GHKCVHG-QCVPLD--ALSYSCQCQDGYSGALC--NQ 1414
C C G+ G C++ A GPC G C +G QC AL+++C+C G+ GA C N
Sbjct: 117 CVCLPGFHGRDCERKA-GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
Query: 1415 AGALAEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGEL------------CEQESECRG 1461
L PC G CL G + S C+C GF+G C++ + CR
Sbjct: 176 DDCLMRPCANGATCLDGINRFS------CLCPEGFAGRFCTINLDDCASRPCQRGARCR- 228
Query: 1462 DPVRDF 1467
D V DF
Sbjct: 229 DRVHDF 234
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 12/97 (12%)
Query: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS-YSCQCQDGYSGALC--NQAGAL 1418
C C G+VG C+ D C C +G LD ++ +SC C +G++G C N
Sbjct: 160 CRCLVGFVGARCEVNVDD-CLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCA 217
Query: 1419 AEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
+ PC RG +C C+C G+ G+ CE
Sbjct: 218 SRPCQRGARC------RDRVHDFDCLCPSGYGGKTCE 248
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 146 bits (368), Expect = 2e-34
Identities = 108/409 (26%), Positives = 175/409 (42%), Gaps = 44/409 (10%)
Query: 1107 CLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQG--NRPVCQCLPGFGGPECEK 1164
CLC EG P CE C G+ CV + C C G G +C
Sbjct: 3780 CLCKEG----------RCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG-QCPG 3828
Query: 1165 LLSVNFVDRDTYLQF--TDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVR 1222
S+ ++Y+++ T+ +N +T+++ T + +++Y D+ +E++ G ++
Sbjct: 3829 SSSMTLTG-NSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQ 3887
Query: 1223 VSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSE 1282
+D GS P + +NDGQ+H V L L +D + G TLN +
Sbjct: 3888 YKFDCGSGPGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLD 3947
Query: 1283 APLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLY-------INNELQDFTKTQMKPGV 1335
++ GG + R Q+ G GF GC+ ++Y +N++ + + + V
Sbjct: 3948 NYVFFGGHIRQQGTRHGRSPQV--GNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDV 4005
Query: 1336 VPGC-----EPCRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG 1389
PGC E C C + G+C P+ G C C A ++G HC+ + PC C++G
Sbjct: 4006 SPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVN-PCSSKPCLYG 4064
Query: 1390 QCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFS 1449
+D + CQC+ Y+G C L+ C+ C +G GA C CD GF
Sbjct: 4065 GTCVVDNGGFVCQCRGLYTGQRCQ----LSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFR 4120
Query: 1450 GELCEQE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1497
GE C+ + EC G+P H A+C+ T C G+ C
Sbjct: 4121 GERCQSDIDECSGNPC--LHG-----ALCENTHGSYHCNCSHEYRGRHC 4162
Score = 124 bits (312), Expect = 5e-28
Identities = 60/154 (38%), Positives = 76/154 (49%), Gaps = 6/154 (3%)
Query: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
C S+PCQN G C+ P Y C C + Y G CE+S++ CSS PC GGTC G
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNG---G 4073
Query: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
F C C + G C + + C D C NGG C D + CQC + G+ C+ +D CS
Sbjct: 4074 FVCQCRGLYTGQRCQL-SPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECS 4132
Query: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSE 1082
NPC H A C T C C Y G +C +
Sbjct: 4133 G--NPCLHGALCENTHGSYHCNCSHEYRGRHCED 4164
Score = 114 bits (286), Expect = 6e-25
Identities = 52/154 (33%), Positives = 77/154 (50%), Gaps = 5/154 (3%)
Query: 966 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVG 1025
+ C+S PC+NGG C+ + C C + G C ++ + C C GG CV G
Sbjct: 4015 EDCASNPCQNGGVCNPSPA--GGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNG 4072
Query: 1026 NYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQD 1085
+ CQC Y G+ C QL C + PC++ C + DG C+C G+ G+ C + D
Sbjct: 4073 GFVCQCRGLYTGQRC-QLSPYCKDE--PCKNGGTCFDSLDGAVCQCDSGFRGERCQSDID 4129
Query: 1086 DCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCE 1119
+C + C +GA C + SY C C+ Y G+ CE
Sbjct: 4130 ECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
Score = 100 bits (249), Expect = 1e-20
Identities = 53/159 (33%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 1006 TDDCVDHACANGGVC-VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTP 1064
T+DC + C NGGVC G Y C+C Y G CE V+ CS PC + CV
Sbjct: 4014 TEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSS--KPCLYGGTCVVDN 4071
Query: 1065 DGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHL 1124
G C+C Y G C + C+D C+NG C D ++ C C G+ G+ C+
Sbjct: 4072 GGFVCQCRGLYTGQRC-QLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQ----- 4125
Query: 1125 PAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
+ C G C +GA C + C C + G CE
Sbjct: 4126 -SDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/40 (37%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 923 QAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCE 962
Q+ D C +PC + C N Y C C Y+GR CE
Sbjct: 4125 QSDIDECSGNPCLHGALCENTH-GSYHCNCSHEYRGRHCE 4163
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,261,224
Number of Sequences: 37866
Number of extensions: 3475196
Number of successful extensions: 24935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 363
Number of HSP's successfully gapped in prelim test: 332
Number of HSP's that attempted gapping in prelim test: 7654
Number of HSP's gapped (non-prelim): 7012
length of query: 1534
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1419
effective length of database: 13,892,928
effective search space: 19714064832
effective search space used: 19714064832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.