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Search of human proteins with 187960109
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187960109 RNA binding motif protein 28 [Homo sapiens]
(759 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187960109 RNA binding motif protein 28 [Homo sapiens] 1501 0.0
gi|226497734 RNA binding motif protein 19 [Homo sapiens] 92 2e-18
gi|226497654 RNA binding motif protein 19 [Homo sapiens] 92 2e-18
gi|226497574 RNA binding motif protein 19 [Homo sapiens] 92 2e-18
gi|55956788 nucleolin [Homo sapiens] 83 1e-15
gi|208431836 poly A binding protein, cytoplasmic 4 isoform 3 [Ho... 82 2e-15
gi|4504715 poly A binding protein, cytoplasmic 4 isoform 2 [Homo... 82 2e-15
gi|208431833 poly A binding protein, cytoplasmic 4 isoform 1 [Ho... 82 2e-15
gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens] 76 1e-13
gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens] 75 2e-13
gi|185135971 poly(A)-binding protein, cytoplasmic 1-like [Homo s... 73 1e-12
gi|228008398 synaptotagmin binding, cytoplasmic RNA interacting ... 71 4e-12
gi|228008295 synaptotagmin binding, cytoplasmic RNA interacting ... 71 4e-12
gi|134152719 CUG triplet repeat, RNA binding protein 2 isoform 4... 71 4e-12
gi|68303645 CUG triplet repeat, RNA binding protein 2 isoform 1 ... 71 4e-12
gi|134152680 CUG triplet repeat, RNA binding protein 2 isoform 2... 71 4e-12
gi|68303647 CUG triplet repeat, RNA binding protein 2 isoform 3 ... 71 4e-12
gi|86991440 splicing factor, arginine/serine-rich 5 [Homo sapiens] 71 4e-12
gi|86991438 splicing factor, arginine/serine-rich 5 [Homo sapiens] 71 4e-12
gi|168229150 poly(A) binding protein, cytoplasmic 4-like [Homo s... 71 4e-12
gi|77695912 TIA-1 related protein isoform 2 [Homo sapiens] 69 2e-11
gi|4507499 TIA-1 related protein isoform 1 [Homo sapiens] 68 3e-11
gi|25470890 DAZ associated protein 1 isoform a [Homo sapiens] 68 4e-11
gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens] 68 4e-11
gi|115511032 ELAV (embryonic lethal, abnormal vision, Drosophila... 67 6e-11
gi|4505255 musashi 1 [Homo sapiens] 67 8e-11
gi|71164871 CUG triplet repeat, RNA-binding protein 1 isoform 3 ... 66 1e-10
gi|5729794 CUG triplet repeat, RNA-binding protein 1 isoform 1 [... 66 1e-10
gi|38570081 CUG triplet repeat, RNA-binding protein 1 isoform 2 ... 66 1e-10
gi|187761301 bruno-like 4, RNA binding protein isoform 3 [Homo s... 66 1e-10
>gi|187960109 RNA binding motif protein 28 [Homo sapiens]
Length = 759
Score = 1501 bits (3886), Expect = 0.0
Identities = 759/759 (100%), Positives = 759/759 (100%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR 60
MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR
Sbjct: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR 60
Query: 61 ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN 120
ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN
Sbjct: 61 ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN 120
Query: 121 LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK 180
LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK
Sbjct: 121 LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK 180
Query: 181 GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD 240
GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD
Sbjct: 181 GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD 240
Query: 241 DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE 300
DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE
Sbjct: 241 DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE 300
Query: 301 ELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGE 360
ELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGE
Sbjct: 301 ELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGE 360
Query: 361 LKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTR 420
LKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTR
Sbjct: 361 LKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTR 420
Query: 421 DEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQ 480
DEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQ
Sbjct: 421 DEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQ 480
Query: 481 NIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSL 540
NIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSL
Sbjct: 481 NIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSL 540
Query: 541 GYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMR 600
GYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMR
Sbjct: 541 GYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMR 600
Query: 601 SKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVE 660
SKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVE
Sbjct: 601 SKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVE 660
Query: 661 LPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKK 720
LPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKK
Sbjct: 661 LPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKK 720
Query: 721 AKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS 759
AKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS
Sbjct: 721 AKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS 759
>gi|226497734 RNA binding motif protein 19 [Homo sapiens]
Length = 960
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/250 (25%), Positives = 121/250 (48%), Gaps = 28/250 (11%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEK---GSKACRGFGYVTFSMLED 57
+ G TLF+ L E+L+E+FS+VG VK C + +K G GFG+V + E
Sbjct: 727 LPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQ 786
Query: 58 VQRALKEIT--TFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKAR 115
Q+ALK++ +G K+ V ++++ + K + P+K+ +K
Sbjct: 787 AQKALKQLQGHVVDGHKLEVRISERATKPAVTLARK---KQVPRKQTTSK---------- 833
Query: 116 LIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRK--PDGKMRGFGFVQFKNLLEAGKALKG 173
+++RN+ F+ +++ +F+ FG + V +P+K G RGFGFV F +A +A
Sbjct: 834 ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNA 893
Query: 174 M-NMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
+ + + GR + ++WA D++ K+ H+ KK+ +++ E+
Sbjct: 894 LCHSTHLYGRRLVLEWA-------DSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQL 946
Query: 233 NDDDDDDDDE 242
D D +++
Sbjct: 947 EGSDSDSEEQ 956
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/353 (24%), Positives = 140/353 (39%), Gaps = 77/353 (21%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKG 173
+RLI++NL E+ + +FA FG + + ++ DGK R FGF+ FK+ EA KA K
Sbjct: 2 SRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKH 61
Query: 174 MNMKEIKGRTVAVDW-----------AVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKG 222
N I + V++ A +K K +Q + + E K E KK
Sbjct: 62 FNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVA 121
Query: 223 REEEDMEEEEN----------------------------------------DDDDDDDDE 242
+ E ++E+ D D + E
Sbjct: 122 GQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESE 181
Query: 243 EDGVFDDEDEEEENIESK--VTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE 300
E+G +D EEE ++E K V K + + A SS SEE+ +E+ D+G
Sbjct: 182 EEGAGEDL-EEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGS 240
Query: 301 ELAQSDTST----EEQEDKAV-----QVSNKKK-------RKLPSDVNEG---KTVFIRN 341
E + D+S +E++ K + KK+ + P++ E TV +R
Sbjct: 241 EAEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRG 300
Query: 342 LSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSK-GCAFAQFMTQEAAQKCL 393
F+ E+ + E L LK V I + + +K G F F +E ++ L
Sbjct: 301 APFNVTEKNVMEFL---APLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQAL 350
Score = 61.6 bits (148), Expect = 3e-09
Identities = 83/366 (22%), Positives = 150/366 (40%), Gaps = 48/366 (13%)
Query: 106 KAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLL 165
+A K ++++NL L+ F FG++ V +P +G + V+F L
Sbjct: 579 QAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLP---EGGITAI--VEFLEPL 633
Query: 166 EAGKALKGMNMKEIKGRTVAVDWAVA---------KDKYKDTQSVSAIGEEKSHES---- 212
EA KA + + + + ++WA K K +DT S + E+
Sbjct: 634 EARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDG 693
Query: 213 --KHQESVKKKGREEEDMEEEENDDDDDDDDE---------EDGVFDDEDEEEENIESKV 261
E+ ++G + + EE ++++++++E ++ FD +E+ + + SKV
Sbjct: 694 ETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKV 753
Query: 262 --TKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDS--------IDDGEELAQSDTSTEE 311
K I K+ K E E++ + DG +L + E
Sbjct: 754 GTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKL---EVRISE 810
Query: 312 QEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLH-P 370
+ K V+ +K+++P K + +RN+ F + E+ EL FGELK VR+
Sbjct: 811 RATKPA-VTLARKKQVPRKQTTSK-ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMT 868
Query: 371 DTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGG--LKLDGRQLKVDL-AVTRDEAAKLQ 427
T +G F F+T++ A++ A G L L+ +V L A+ R AA
Sbjct: 869 GTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFH 928
Query: 428 TTKVKK 433
KK
Sbjct: 929 EPPKKK 934
Score = 56.6 bits (135), Expect = 8e-08
Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 18/211 (8%)
Query: 12 PPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFEGC 71
P + + + E + + PV V G+K G+ +V FS E+V++ALK + G
Sbjct: 302 PFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKT--GYIFVDFSNEEEVKQALKCNREYMGG 359
Query: 72 KI-------NVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ NV K +N TK E ++E A+ RL +RNL +
Sbjct: 360 RYIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESG-------RLFVRNLPYT 412
Query: 125 CSEDDLKTVFAQFGAVLEVNIP-RKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+E+DL+ +F+++G + E++ P K +GF F+ F A KA ++ + +GR
Sbjct: 413 STEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRM 472
Query: 184 VAV-DWAVAKDKYKDTQSVSAIGEEKSHESK 213
+ V + K+ +D ++ + +K E++
Sbjct: 473 LHVLPSTIKKEASEDASALGSSSYKKKKEAQ 503
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 4/107 (3%)
Query: 84 NKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEV 143
N T+E N +++ ++E + ++ + + L I+NL+F +E+ LK VF++ G V
Sbjct: 700 NPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSC 759
Query: 144 NIPRKPDGK----MRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAV 186
+I +K + GFGFV+++ +A KALK + + G + V
Sbjct: 760 SISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEV 806
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
LFV LP ++ E LE+LFS+ GP+ + + +K +GF ++TF E +A E+
Sbjct: 404 LFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEV 463
Query: 66 --TTFEGCKINV--TVAKKKLRNKTKEKGKNENSECPKKEPKAKKA 107
F+G ++V + KK+ G + + + + KA A
Sbjct: 464 DGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSA 509
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 330 DVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAA 389
D+ E +F+RNL + S EE+L +L ++G L + + T+ KG AF FM E A
Sbjct: 397 DLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHA 456
Query: 390 QKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
K +E G GR L V + + EA++
Sbjct: 457 VKAY------SEVDGQVFQGRMLHVLPSTIKKEASE 486
>gi|226497654 RNA binding motif protein 19 [Homo sapiens]
Length = 960
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/250 (25%), Positives = 121/250 (48%), Gaps = 28/250 (11%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEK---GSKACRGFGYVTFSMLED 57
+ G TLF+ L E+L+E+FS+VG VK C + +K G GFG+V + E
Sbjct: 727 LPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQ 786
Query: 58 VQRALKEIT--TFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKAR 115
Q+ALK++ +G K+ V ++++ + K + P+K+ +K
Sbjct: 787 AQKALKQLQGHVVDGHKLEVRISERATKPAVTLARK---KQVPRKQTTSK---------- 833
Query: 116 LIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRK--PDGKMRGFGFVQFKNLLEAGKALKG 173
+++RN+ F+ +++ +F+ FG + V +P+K G RGFGFV F +A +A
Sbjct: 834 ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNA 893
Query: 174 M-NMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
+ + + GR + ++WA D++ K+ H+ KK+ +++ E+
Sbjct: 894 LCHSTHLYGRRLVLEWA-------DSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQL 946
Query: 233 NDDDDDDDDE 242
D D +++
Sbjct: 947 EGSDSDSEEQ 956
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/353 (24%), Positives = 140/353 (39%), Gaps = 77/353 (21%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKG 173
+RLI++NL E+ + +FA FG + + ++ DGK R FGF+ FK+ EA KA K
Sbjct: 2 SRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKH 61
Query: 174 MNMKEIKGRTVAVDW-----------AVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKG 222
N I + V++ A +K K +Q + + E K E KK
Sbjct: 62 FNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVA 121
Query: 223 REEEDMEEEEN----------------------------------------DDDDDDDDE 242
+ E ++E+ D D + E
Sbjct: 122 GQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESE 181
Query: 243 EDGVFDDEDEEEENIESK--VTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE 300
E+G +D EEE ++E K V K + + A SS SEE+ +E+ D+G
Sbjct: 182 EEGAGEDL-EEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGS 240
Query: 301 ELAQSDTST----EEQEDKAV-----QVSNKKK-------RKLPSDVNEG---KTVFIRN 341
E + D+S +E++ K + KK+ + P++ E TV +R
Sbjct: 241 EAEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRG 300
Query: 342 LSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSK-GCAFAQFMTQEAAQKCL 393
F+ E+ + E L LK V I + + +K G F F +E ++ L
Sbjct: 301 APFNVTEKNVMEFL---APLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQAL 350
Score = 61.6 bits (148), Expect = 3e-09
Identities = 83/366 (22%), Positives = 150/366 (40%), Gaps = 48/366 (13%)
Query: 106 KAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLL 165
+A K ++++NL L+ F FG++ V +P +G + V+F L
Sbjct: 579 QAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLP---EGGITAI--VEFLEPL 633
Query: 166 EAGKALKGMNMKEIKGRTVAVDWAVA---------KDKYKDTQSVSAIGEEKSHES---- 212
EA KA + + + + ++WA K K +DT S + E+
Sbjct: 634 EARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDG 693
Query: 213 --KHQESVKKKGREEEDMEEEENDDDDDDDDE---------EDGVFDDEDEEEENIESKV 261
E+ ++G + + EE ++++++++E ++ FD +E+ + + SKV
Sbjct: 694 ETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKV 753
Query: 262 --TKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDS--------IDDGEELAQSDTSTEE 311
K I K+ K E E++ + DG +L + E
Sbjct: 754 GTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKL---EVRISE 810
Query: 312 QEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLH-P 370
+ K V+ +K+++P K + +RN+ F + E+ EL FGELK VR+
Sbjct: 811 RATKPA-VTLARKKQVPRKQTTSK-ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMT 868
Query: 371 DTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGG--LKLDGRQLKVDL-AVTRDEAAKLQ 427
T +G F F+T++ A++ A G L L+ +V L A+ R AA
Sbjct: 869 GTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFH 928
Query: 428 TTKVKK 433
KK
Sbjct: 929 EPPKKK 934
Score = 56.6 bits (135), Expect = 8e-08
Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 18/211 (8%)
Query: 12 PPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFEGC 71
P + + + E + + PV V G+K G+ +V FS E+V++ALK + G
Sbjct: 302 PFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKT--GYIFVDFSNEEEVKQALKCNREYMGG 359
Query: 72 KI-------NVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ NV K +N TK E ++E A+ RL +RNL +
Sbjct: 360 RYIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESG-------RLFVRNLPYT 412
Query: 125 CSEDDLKTVFAQFGAVLEVNIP-RKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+E+DL+ +F+++G + E++ P K +GF F+ F A KA ++ + +GR
Sbjct: 413 STEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRM 472
Query: 184 VAV-DWAVAKDKYKDTQSVSAIGEEKSHESK 213
+ V + K+ +D ++ + +K E++
Sbjct: 473 LHVLPSTIKKEASEDASALGSSSYKKKKEAQ 503
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 4/107 (3%)
Query: 84 NKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEV 143
N T+E N +++ ++E + ++ + + L I+NL+F +E+ LK VF++ G V
Sbjct: 700 NPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSC 759
Query: 144 NIPRKPDGK----MRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAV 186
+I +K + GFGFV+++ +A KALK + + G + V
Sbjct: 760 SISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEV 806
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
LFV LP ++ E LE+LFS+ GP+ + + +K +GF ++TF E +A E+
Sbjct: 404 LFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEV 463
Query: 66 --TTFEGCKINV--TVAKKKLRNKTKEKGKNENSECPKKEPKAKKA 107
F+G ++V + KK+ G + + + + KA A
Sbjct: 464 DGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSA 509
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 330 DVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAA 389
D+ E +F+RNL + S EE+L +L ++G L + + T+ KG AF FM E A
Sbjct: 397 DLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHA 456
Query: 390 QKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
K +E G GR L V + + EA++
Sbjct: 457 VKAY------SEVDGQVFQGRMLHVLPSTIKKEASE 486
>gi|226497574 RNA binding motif protein 19 [Homo sapiens]
Length = 960
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/250 (25%), Positives = 121/250 (48%), Gaps = 28/250 (11%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEK---GSKACRGFGYVTFSMLED 57
+ G TLF+ L E+L+E+FS+VG VK C + +K G GFG+V + E
Sbjct: 727 LPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQ 786
Query: 58 VQRALKEIT--TFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKAR 115
Q+ALK++ +G K+ V ++++ + K + P+K+ +K
Sbjct: 787 AQKALKQLQGHVVDGHKLEVRISERATKPAVTLARK---KQVPRKQTTSK---------- 833
Query: 116 LIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRK--PDGKMRGFGFVQFKNLLEAGKALKG 173
+++RN+ F+ +++ +F+ FG + V +P+K G RGFGFV F +A +A
Sbjct: 834 ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNA 893
Query: 174 M-NMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
+ + + GR + ++WA D++ K+ H+ KK+ +++ E+
Sbjct: 894 LCHSTHLYGRRLVLEWA-------DSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQL 946
Query: 233 NDDDDDDDDE 242
D D +++
Sbjct: 947 EGSDSDSEEQ 956
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/353 (24%), Positives = 140/353 (39%), Gaps = 77/353 (21%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKG 173
+RLI++NL E+ + +FA FG + + ++ DGK R FGF+ FK+ EA KA K
Sbjct: 2 SRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKH 61
Query: 174 MNMKEIKGRTVAVDW-----------AVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKG 222
N I + V++ A +K K +Q + + E K E KK
Sbjct: 62 FNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVA 121
Query: 223 REEEDMEEEEN----------------------------------------DDDDDDDDE 242
+ E ++E+ D D + E
Sbjct: 122 GQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESE 181
Query: 243 EDGVFDDEDEEEENIESK--VTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE 300
E+G +D EEE ++E K V K + + A SS SEE+ +E+ D+G
Sbjct: 182 EEGAGEDL-EEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGS 240
Query: 301 ELAQSDTST----EEQEDKAV-----QVSNKKK-------RKLPSDVNEG---KTVFIRN 341
E + D+S +E++ K + KK+ + P++ E TV +R
Sbjct: 241 EAEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRG 300
Query: 342 LSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSK-GCAFAQFMTQEAAQKCL 393
F+ E+ + E L LK V I + + +K G F F +E ++ L
Sbjct: 301 APFNVTEKNVMEFL---APLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQAL 350
Score = 61.6 bits (148), Expect = 3e-09
Identities = 83/366 (22%), Positives = 150/366 (40%), Gaps = 48/366 (13%)
Query: 106 KAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLL 165
+A K ++++NL L+ F FG++ V +P +G + V+F L
Sbjct: 579 QAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLP---EGGITAI--VEFLEPL 633
Query: 166 EAGKALKGMNMKEIKGRTVAVDWAVA---------KDKYKDTQSVSAIGEEKSHES---- 212
EA KA + + + + ++WA K K +DT S + E+
Sbjct: 634 EARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDG 693
Query: 213 --KHQESVKKKGREEEDMEEEENDDDDDDDDE---------EDGVFDDEDEEEENIESKV 261
E+ ++G + + EE ++++++++E ++ FD +E+ + + SKV
Sbjct: 694 ETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKV 753
Query: 262 --TKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDS--------IDDGEELAQSDTSTEE 311
K I K+ K E E++ + DG +L + E
Sbjct: 754 GTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKL---EVRISE 810
Query: 312 QEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLH-P 370
+ K V+ +K+++P K + +RN+ F + E+ EL FGELK VR+
Sbjct: 811 RATKPA-VTLARKKQVPRKQTTSK-ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMT 868
Query: 371 DTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGG--LKLDGRQLKVDL-AVTRDEAAKLQ 427
T +G F F+T++ A++ A G L L+ +V L A+ R AA
Sbjct: 869 GTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFH 928
Query: 428 TTKVKK 433
KK
Sbjct: 929 EPPKKK 934
Score = 56.6 bits (135), Expect = 8e-08
Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 18/211 (8%)
Query: 12 PPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFEGC 71
P + + + E + + PV V G+K G+ +V FS E+V++ALK + G
Sbjct: 302 PFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKT--GYIFVDFSNEEEVKQALKCNREYMGG 359
Query: 72 KI-------NVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ NV K +N TK E ++E A+ RL +RNL +
Sbjct: 360 RYIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESG-------RLFVRNLPYT 412
Query: 125 CSEDDLKTVFAQFGAVLEVNIP-RKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+E+DL+ +F+++G + E++ P K +GF F+ F A KA ++ + +GR
Sbjct: 413 STEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRM 472
Query: 184 VAV-DWAVAKDKYKDTQSVSAIGEEKSHESK 213
+ V + K+ +D ++ + +K E++
Sbjct: 473 LHVLPSTIKKEASEDASALGSSSYKKKKEAQ 503
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 4/107 (3%)
Query: 84 NKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEV 143
N T+E N +++ ++E + ++ + + L I+NL+F +E+ LK VF++ G V
Sbjct: 700 NPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSC 759
Query: 144 NIPRKPDGK----MRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAV 186
+I +K + GFGFV+++ +A KALK + + G + V
Sbjct: 760 SISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEV 806
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
LFV LP ++ E LE+LFS+ GP+ + + +K +GF ++TF E +A E+
Sbjct: 404 LFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEV 463
Query: 66 --TTFEGCKINV--TVAKKKLRNKTKEKGKNENSECPKKEPKAKKA 107
F+G ++V + KK+ G + + + + KA A
Sbjct: 464 DGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSA 509
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 330 DVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAA 389
D+ E +F+RNL + S EE+L +L ++G L + + T+ KG AF FM E A
Sbjct: 397 DLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHA 456
Query: 390 QKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
K +E G GR L V + + EA++
Sbjct: 457 VKAY------SEVDGQVFQGRMLHVLPSTIKKEASE 486
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 82.8 bits (203), Expect = 1e-15
Identities = 103/418 (24%), Positives = 178/418 (42%), Gaps = 77/418 (18%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
LFVG L + + +L+ S V K V + R FGYV F ED+++AL E+
Sbjct: 309 LFVGNLNFNKSAPELKTGISDVF-AKNDLAVVDVRIGMTRKFGYVDFESAEDLEKAL-EL 366
Query: 66 TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKC 125
T G K+ +E ++PK K +K L+ +NL +K
Sbjct: 367 T---GLKVF-------------------GNEIKLEKPKGKDSKKERDARTLLAKNLPYKV 404
Query: 126 SEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVA 185
++D+LK VF E+ + K DGK +G +++FK +A K + EI GR+++
Sbjct: 405 TQDELKEVFED---AAEIRLVSK-DGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSIS 460
Query: 186 VDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEEDG 245
+ + K + +D + G + S S +++ EE
Sbjct: 461 LYYTGEKGQNQDYR-----GGKNSTWSGESKTLVLSNLSYSATEETLQ------------ 503
Query: 246 VFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGEELAQS 305
++ ++A P + S+ + +E + S +D +E A +
Sbjct: 504 --------------------EVFEKATFIKVPQNQNGKSKGYAFIEFA-SFEDAKE-ALN 541
Query: 306 DTSTEEQEDKAVQVSNKKKRKLPSDVNE-GKTVFIRNLSFDSEEEELGELLQQFGELKYV 364
+ E E +A+++ + R P+ ++ KT+F++ LS D+ EE L E F
Sbjct: 542 SCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKE---SFDGSVRA 598
Query: 365 RIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDE 422
RIV +T SKG F F ++E A+ AA E G ++DG ++ +D A + E
Sbjct: 599 RIVTDRETGSSKGFGFVDFNSEEDAK----AAKEAMEDG--EIDGNKVTLDWAKPKGE 650
Score = 73.6 bits (179), Expect = 7e-13
Identities = 120/518 (23%), Positives = 201/518 (38%), Gaps = 119/518 (22%)
Query: 208 KSHESKHQESVKKKGREEEDMEEEENDDD------------------DDDDDEEDGVFDD 249
K +S +E + EE+D +E+E++D+ DD+DDE+D DD
Sbjct: 141 KKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDD 200
Query: 250 EDEEEENIESKVTKPVQIQKRAVKRPAPAKS--------SDHSEEDSDLEESDSIDDGEE 301
++E++ E+ T P + +K A P AK+ D +ED D +E D DD E+
Sbjct: 201 DEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDED 260
Query: 302 LAQSDTSTEEQEDKAVQVSNKK---KRKLPSDVNEGK----------TVFIRNLSFDSEE 348
+ + EE+ K KK K+K + + K +F+ NL+F+
Sbjct: 261 DEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSA 320
Query: 349 EELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLD 408
EL + K V+ ++ + F + E +K L E GLK+
Sbjct: 321 PELKTGISDV-FAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKAL-------ELTGLKVF 372
Query: 409 GRQLKVD----------------------LAVTRDE-------AAKLQ-TTKVKKPTGTR 438
G ++K++ VT+DE AA+++ +K K G
Sbjct: 373 GNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIA 432
Query: 439 NLYLAREGLI------RAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLH 492
+ E + GT+ +G S + E+ + ++ K+ L L
Sbjct: 433 YIEFKTEADAEKTFEEKQGTE-IDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLS 491
Query: 493 NLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEH 552
NL + ++ L+++ EK IK V N G+S GYAF EF E
Sbjct: 492 NLSYSATEETLQEVF------EKATFIK----------VPQNQNGKSKGYAFIEFASFED 535
Query: 553 ALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMRSKPATGEPQKGQ 612
A +AL N KR I + R +++ EL+ R RS+P+ KG
Sbjct: 536 AKEALNSCN---------KREI------EGRAIRL-ELQGPRGSPNARSQPSKTLFVKGL 579
Query: 613 PEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGF 650
E D ++ + + + R+ GS+ GF
Sbjct: 580 SE---DTTEETLKESFDGSVRARIVTDRETGSSKGFGF 614
Score = 72.8 bits (177), Expect = 1e-12
Identities = 63/270 (23%), Positives = 125/270 (46%), Gaps = 34/270 (12%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
TL LP ++L+E+F ++ +V++ G +G Y+ F D ++ +E
Sbjct: 394 TLLAKNLPYKVTQDELKEVFEDAAEIR---LVSKDGKS--KGIAYIEFKTEADAEKTFEE 448
Query: 65 I--TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLS 122
T +G I++ T EKG+N++ K + ++K L++ NLS
Sbjct: 449 KQGTEIDGRSISLYY--------TGEKGQNQDYRGGKNSTWSGESKT------LVLSNLS 494
Query: 123 FKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGR 182
+ +E+ L+ VF + + +P+ +GK +G+ F++F + +A +AL N +EI+GR
Sbjct: 495 YSATEETLQEVFEK---ATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGR 551
Query: 183 TVAVDW------AVAKDKYKDTQSVSAIGEEKSHESKHQE---SVKKKGREEEDMEEEEN 233
+ ++ A+ + T V + E+ + E+ + SV+ + + + +
Sbjct: 552 AIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKG 611
Query: 234 DDDDDDDDEEDGVFDDEDEEEENIE-SKVT 262
D + EED E E+ I+ +KVT
Sbjct: 612 FGFVDFNSEEDAKAAKEAMEDGEIDGNKVT 641
Score = 62.0 bits (149), Expect = 2e-09
Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 10/114 (8%)
Query: 220 KKGREEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAK 279
K G+ + + +E +DDD ++DEED +DEDE+E+ IE K A PA
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDD--EDEDEDEDEIEPAA------MKAAAAAPASED 186
Query: 280 SSDHSEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNE 333
D +ED + ++ D DD EE A T + + KA +V K + + D +E
Sbjct: 187 EDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGK--KAAKVVPVKAKNVAEDEDE 238
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/138 (29%), Positives = 72/138 (52%), Gaps = 21/138 (15%)
Query: 213 KHQESVKKKGREEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAV 272
K ++ KG + ++E+ D+++DDD E+ DDEDE+E+ E I+ A+
Sbjct: 124 KKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDE--------IEPAAM 175
Query: 273 KRPAPAKSSDHSEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVN 332
K A A +S+ E+D D E+ + DD EE ++ E++A++ + K +K V
Sbjct: 176 KAAAAAPASE-DEDDEDDEDDEDDDDDEE--------DDSEEEAMETTPAKGKKAAKVV- 225
Query: 333 EGKTVFIRNLSFDSEEEE 350
V +N++ D +EEE
Sbjct: 226 ---PVKAKNVAEDEDEEE 240
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/190 (26%), Positives = 82/190 (43%), Gaps = 30/190 (15%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
TL + L SA E L+E+F + +K V + + +G+ ++ F+ ED + AL
Sbjct: 487 TLVLSNLSYSATEETLQEVFEKATFIK----VPQNQNGKSKGYAFIEFASFEDAKEALNS 542
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSEC--PKKEPKAKKAKVADKKARLIIRNLS 122
NK + +G+ E P+ P A+ + L ++ LS
Sbjct: 543 C------------------NKREIEGRAIRLELQGPRGSPNAR----SQPSKTLFVKGLS 580
Query: 123 FKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGR 182
+E+ LK F G+V + + G +GFGFV F + +A A + M EI G
Sbjct: 581 EDTTEETLKESFD--GSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGN 638
Query: 183 TVAVDWAVAK 192
V +DWA K
Sbjct: 639 KVTLDWAKPK 648
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/368 (24%), Positives = 154/368 (41%), Gaps = 73/368 (19%)
Query: 99 KKEPKAKKAKVADKKA----RLIIRNLSFKCSEDDLKT----VFAQFG-AVLEVNIPRKP 149
K P+AKK KV + L + NL+F S +LKT VFA+ AV++V I
Sbjct: 288 KAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRI---- 343
Query: 150 DGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKS 209
G R FG+V F++ + KAL+ +K + G + ++ KD K+ + + + +
Sbjct: 344 -GMTRKFGYVDFESAEDLEKALELTGLK-VFGNEIKLEKPKGKDSKKERDARTLLAKNLP 401
Query: 210 HESKHQESVKKKGREEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQK 269
++ DE VF ED E + SK K I
Sbjct: 402 YKVTQ--------------------------DELKEVF--EDAAEIRLVSKDGKSKGIAY 433
Query: 270 RAVKRPAPAKSSDHSEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPS 329
K A A+ + ++ +++ DG ++ T + Q + + K +
Sbjct: 434 IEFKTEADAEKTFEEKQGTEI-------DGRSISLYYTGEKGQNQ------DYRGGKNST 480
Query: 330 DVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAA 389
E KT+ + NLS+ + EE L E+ ++ +K V SKG AF +F + E A
Sbjct: 481 WSGESKTLVLSNLSYSATEETLQEVFEKATFIK----VPQNQNGKSKGYAFIEFASFEDA 536
Query: 390 QKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEA-AKLQTTK------VKKPTGTRNLYL 442
++ L N +++GR ++++L R A+ Q +K + + T L
Sbjct: 537 KEAL------NSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKE 590
Query: 443 AREGLIRA 450
+ +G +RA
Sbjct: 591 SFDGSVRA 598
Score = 41.6 bits (96), Expect = 0.003
Identities = 54/266 (20%), Positives = 106/266 (39%), Gaps = 41/266 (15%)
Query: 169 KALKGMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDM 228
K K + +K + VA D +D+ +D + +E + + E + EEE+
Sbjct: 217 KGKKAAKVVPVKAKNVAED----EDEEEDDE------DEDDDDDEDDEDDDDEDDEEEEE 266
Query: 229 EEEENDDDD------DDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSD 282
EEEE + + ++ + + ++ E E + + + AP +
Sbjct: 267 EEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTG 326
Query: 283 HSE--EDSDLEESD-SIDDGEELAQSDTSTEEQEDKAVQVS-----------NKKKRKLP 328
S+ +DL D I + D + E +KA++++ K K K
Sbjct: 327 ISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDS 386
Query: 329 SDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
+ +T+ +NL + ++EL E+ + E++ V SKG A+ +F T+
Sbjct: 387 KKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLV-----SKDGKSKGIAYIEFKTEAD 441
Query: 389 AQKCLLAASPENEAGGLKLDGRQLKV 414
A+K E G ++DGR + +
Sbjct: 442 AEKTF------EEKQGTEIDGRSISL 461
Score = 30.8 bits (68), Expect = 4.9
Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 13/99 (13%)
Query: 225 EEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHS 284
EED E+EE +D++DD + V + + ++ + K V + V PAK +
Sbjct: 25 EEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKA--- 81
Query: 285 EEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKK 323
++ G++ A + KAV KK
Sbjct: 82 ----------AVTPGKKAAATPAKKTVTPAKAVTTPGKK 110
>gi|208431836 poly A binding protein, cytoplasmic 4 isoform 3 [Homo
sapiens]
Length = 631
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 20/188 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVT-EKGSKACRGFGYVTFSMLEDVQRALKE 64
+F+ L S ++ L + FS G + C VV E GSK G+ +V F E +A+++
Sbjct: 101 VFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSK---GYAFVHFETQEAADKAIEK 157
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ V V + K R KE +A+ A + + I+N +
Sbjct: 158 MNGMLLNDRKVFVGRFKSR----------------KEREAELGAKAKEFTNVYIKNFGEE 201
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ LK +F+QFG L V + R P+GK +GFGFV ++ +A KA++ MN KEI G+ +
Sbjct: 202 VDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKII 261
Query: 185 AVDWAVAK 192
V A K
Sbjct: 262 FVGRAQKK 269
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 79/448 (17%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L L E FS GPV V + ++ G+ YV F D +RAL
Sbjct: 12 SLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK +++P +K+ V + + I+NL
Sbjct: 72 M------------------NFDVIKGKPIRIMWSQRDPSLRKSGVGN----VFIKNLDKS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + +G +G+ FV F+ A KA++ MN + R V
Sbjct: 110 IDNKALYDTFSAFGNILSCKVVCDENGS-KGYAFVHFETQEAADKAIEKMNGMLLNDRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G KS + + E + K +E ++ + ++ D
Sbjct: 169 FV------------------GRFKSRKEREAE-LGAKAKEFTNVYIKNFGEEVD------ 203
Query: 245 GVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHS----EEDSDLEESDSIDDGE 300
DE + + S+ K + ++ V R KS E+ D ++ +G+
Sbjct: 204 ------DESLKELFSQFGKTLSVK---VMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGK 254
Query: 301 ELA-------QSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGE 353
E++ ++ E Q + + K+ ++ +G ++I+NL ++E+L +
Sbjct: 255 EISGKIIFVGRAQKKVERQAELKRKFEQLKQERISR--YQGVNLYIKNLDDTIDDEKLRK 312
Query: 354 LLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLK 413
FG + +++L + SKG F F + E A K + E G + + L
Sbjct: 313 EFSPFGSITSAKVML--EDGRSKGFGFVCFSSPEEATKAV------TEMNGRIVGSKPLY 364
Query: 414 VDLAVTRDE-AAKLQTTKVKKPTGTRNL 440
V LA ++E A L +++ G R L
Sbjct: 365 VALAQRKEERKAHLTNQYMQRVAGMRAL 392
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/548 (21%), Positives = 201/548 (36%), Gaps = 121/548 (22%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G VL + + R + G+ +V F+ +A +AL
Sbjct: 11 ASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALD 70
Query: 173 GMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
MN IKG+ + + W S+ S++K G ++ +
Sbjct: 71 TMNFDVIKGKPIRIMW-----------------------SQRDPSLRKSGVGNVFIKNLD 107
Query: 233 NDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEE 292
D+ ++D + KV + K A D +E+
Sbjct: 108 KSIDN------KALYDTFSAFGNILSCKVV----CDENGSKGYAFVHFETQEAADKAIEK 157
Query: 293 SDS--IDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEE 350
+ ++D + S +E+E +L + E V+I+N + ++E
Sbjct: 158 MNGMLLNDRKVFVGRFKSRKERE-----------AELGAKAKEFTNVYIKNFGEEVDDES 206
Query: 351 LGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGR 410
L EL QFG+ V+++ P+ + SKG F + E A K + E G ++ G+
Sbjct: 207 LKELFSQFGKTLSVKVMRDPNGK-SKGFGFVSYEKHEDANKAV------EEMNGKEISGK 259
Query: 411 QLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFE 470
+ V A + E + AE + +FE
Sbjct: 260 IIFVGRAQKKVE------------------------------RQAE--------LKRKFE 281
Query: 471 LLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKG 530
LK +++ L + NL +DD++LRK S I +VM +
Sbjct: 282 QLKQERISR----YQGVNLYIKNLDDTIDDEKLRKEFSPFGS------ITSAKVMLE--- 328
Query: 531 VHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKEL 590
G+S G+ F F E A KA+ +N I G + ++ RK +
Sbjct: 329 -----DGRSKGFGFVCFSSPEEATKAVTEMNG--RIVGSKPLYVALAQRKEERKAHLTNQ 381
Query: 591 RIQRSLQKMRSKPATGEPQKGQPE------PAKDQQQKAAQHHTEEQ-SKVPPEQKRKAG 643
+QR + MR+ PA + QP PA Q Q ++T Q +++ P + + G
Sbjct: 382 YMQR-VAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQG 440
Query: 644 STSWTGFQ 651
GFQ
Sbjct: 441 GRP-QGFQ 447
>gi|4504715 poly A binding protein, cytoplasmic 4 isoform 2 [Homo
sapiens]
Length = 644
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 20/188 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVT-EKGSKACRGFGYVTFSMLEDVQRALKE 64
+F+ L S ++ L + FS G + C VV E GSK G+ +V F E +A+++
Sbjct: 101 VFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSK---GYAFVHFETQEAADKAIEK 157
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ V V + K R KE +A+ A + + I+N +
Sbjct: 158 MNGMLLNDRKVFVGRFKSR----------------KEREAELGAKAKEFTNVYIKNFGEE 201
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ LK +F+QFG L V + R P+GK +GFGFV ++ +A KA++ MN KEI G+ +
Sbjct: 202 VDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKII 261
Query: 185 AVDWAVAK 192
V A K
Sbjct: 262 FVGRAQKK 269
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 79/448 (17%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L L E FS GPV V + ++ G+ YV F D +RAL
Sbjct: 12 SLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK +++P +K+ V + + I+NL
Sbjct: 72 M------------------NFDVIKGKPIRIMWSQRDPSLRKSGVGN----VFIKNLDKS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + +G +G+ FV F+ A KA++ MN + R V
Sbjct: 110 IDNKALYDTFSAFGNILSCKVVCDENGS-KGYAFVHFETQEAADKAIEKMNGMLLNDRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G KS + + E + K +E ++ + ++ D
Sbjct: 169 FV------------------GRFKSRKEREAE-LGAKAKEFTNVYIKNFGEEVD------ 203
Query: 245 GVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHS----EEDSDLEESDSIDDGE 300
DE + + S+ K + ++ V R KS E+ D ++ +G+
Sbjct: 204 ------DESLKELFSQFGKTLSVK---VMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGK 254
Query: 301 ELA-------QSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGE 353
E++ ++ E Q + + K+ ++ +G ++I+NL ++E+L +
Sbjct: 255 EISGKIIFVGRAQKKVERQAELKRKFEQLKQERISR--YQGVNLYIKNLDDTIDDEKLRK 312
Query: 354 LLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLK 413
FG + +++L + SKG F F + E A K + E G + + L
Sbjct: 313 EFSPFGSITSAKVML--EDGRSKGFGFVCFSSPEEATKAV------TEMNGRIVGSKPLY 364
Query: 414 VDLAVTRDE-AAKLQTTKVKKPTGTRNL 440
V LA ++E A L +++ G R L
Sbjct: 365 VALAQRKEERKAHLTNQYMQRVAGMRAL 392
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/548 (21%), Positives = 201/548 (36%), Gaps = 121/548 (22%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G VL + + R + G+ +V F+ +A +AL
Sbjct: 11 ASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALD 70
Query: 173 GMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
MN IKG+ + + W S+ S++K G ++ +
Sbjct: 71 TMNFDVIKGKPIRIMW-----------------------SQRDPSLRKSGVGNVFIKNLD 107
Query: 233 NDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEE 292
D+ ++D + KV + K A D +E+
Sbjct: 108 KSIDN------KALYDTFSAFGNILSCKVV----CDENGSKGYAFVHFETQEAADKAIEK 157
Query: 293 SDS--IDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEE 350
+ ++D + S +E+E +L + E V+I+N + ++E
Sbjct: 158 MNGMLLNDRKVFVGRFKSRKERE-----------AELGAKAKEFTNVYIKNFGEEVDDES 206
Query: 351 LGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGR 410
L EL QFG+ V+++ P+ + SKG F + E A K + E G ++ G+
Sbjct: 207 LKELFSQFGKTLSVKVMRDPNGK-SKGFGFVSYEKHEDANKAV------EEMNGKEISGK 259
Query: 411 QLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFE 470
+ V A + E + AE + +FE
Sbjct: 260 IIFVGRAQKKVE------------------------------RQAE--------LKRKFE 281
Query: 471 LLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKG 530
LK +++ L + NL +DD++LRK S I +VM +
Sbjct: 282 QLKQERISR----YQGVNLYIKNLDDTIDDEKLRKEFSPFGS------ITSAKVMLE--- 328
Query: 531 VHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKEL 590
G+S G+ F F E A KA+ +N I G + ++ RK +
Sbjct: 329 -----DGRSKGFGFVCFSSPEEATKAVTEMNG--RIVGSKPLYVALAQRKEERKAHLTNQ 381
Query: 591 RIQRSLQKMRSKPATGEPQKGQPE------PAKDQQQKAAQHHTEEQ-SKVPPEQKRKAG 643
+QR + MR+ PA + QP PA Q Q ++T Q +++ P + + G
Sbjct: 382 YMQR-VAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQG 440
Query: 644 STSWTGFQ 651
GFQ
Sbjct: 441 GRP-QGFQ 447
>gi|208431833 poly A binding protein, cytoplasmic 4 isoform 1 [Homo
sapiens]
Length = 660
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 20/188 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVT-EKGSKACRGFGYVTFSMLEDVQRALKE 64
+F+ L S ++ L + FS G + C VV E GSK G+ +V F E +A+++
Sbjct: 101 VFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSK---GYAFVHFETQEAADKAIEK 157
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ V V + K R KE +A+ A + + I+N +
Sbjct: 158 MNGMLLNDRKVFVGRFKSR----------------KEREAELGAKAKEFTNVYIKNFGEE 201
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ LK +F+QFG L V + R P+GK +GFGFV ++ +A KA++ MN KEI G+ +
Sbjct: 202 VDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKII 261
Query: 185 AVDWAVAK 192
V A K
Sbjct: 262 FVGRAQKK 269
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 79/448 (17%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L L E FS GPV V + ++ G+ YV F D +RAL
Sbjct: 12 SLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK +++P +K+ V + + I+NL
Sbjct: 72 M------------------NFDVIKGKPIRIMWSQRDPSLRKSGVGN----VFIKNLDKS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + +G +G+ FV F+ A KA++ MN + R V
Sbjct: 110 IDNKALYDTFSAFGNILSCKVVCDENGS-KGYAFVHFETQEAADKAIEKMNGMLLNDRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G KS + + E + K +E ++ + ++ D
Sbjct: 169 FV------------------GRFKSRKEREAE-LGAKAKEFTNVYIKNFGEEVD------ 203
Query: 245 GVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHS----EEDSDLEESDSIDDGE 300
DE + + S+ K + ++ V R KS E+ D ++ +G+
Sbjct: 204 ------DESLKELFSQFGKTLSVK---VMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGK 254
Query: 301 ELA-------QSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGE 353
E++ ++ E Q + + K+ ++ +G ++I+NL ++E+L +
Sbjct: 255 EISGKIIFVGRAQKKVERQAELKRKFEQLKQERISR--YQGVNLYIKNLDDTIDDEKLRK 312
Query: 354 LLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLK 413
FG + +++L + SKG F F + E A K + E G + + L
Sbjct: 313 EFSPFGSITSAKVML--EDGRSKGFGFVCFSSPEEATKAV------TEMNGRIVGSKPLY 364
Query: 414 VDLAVTRDE-AAKLQTTKVKKPTGTRNL 440
V LA ++E A L +++ G R L
Sbjct: 365 VALAQRKEERKAHLTNQYMQRVAGMRAL 392
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/548 (21%), Positives = 201/548 (36%), Gaps = 121/548 (22%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G VL + + R + G+ +V F+ +A +AL
Sbjct: 11 ASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALD 70
Query: 173 GMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEE 232
MN IKG+ + + W S+ S++K G ++ +
Sbjct: 71 TMNFDVIKGKPIRIMW-----------------------SQRDPSLRKSGVGNVFIKNLD 107
Query: 233 NDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEE 292
D+ ++D + KV + K A D +E+
Sbjct: 108 KSIDN------KALYDTFSAFGNILSCKVV----CDENGSKGYAFVHFETQEAADKAIEK 157
Query: 293 SDS--IDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEE 350
+ ++D + S +E+E +L + E V+I+N + ++E
Sbjct: 158 MNGMLLNDRKVFVGRFKSRKERE-----------AELGAKAKEFTNVYIKNFGEEVDDES 206
Query: 351 LGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGR 410
L EL QFG+ V+++ P+ + SKG F + E A K + E G ++ G+
Sbjct: 207 LKELFSQFGKTLSVKVMRDPNGK-SKGFGFVSYEKHEDANKAV------EEMNGKEISGK 259
Query: 411 QLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFE 470
+ V A + E + AE + +FE
Sbjct: 260 IIFVGRAQKKVE------------------------------RQAE--------LKRKFE 281
Query: 471 LLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKG 530
LK +++ L + NL +DD++LRK S I +VM +
Sbjct: 282 QLKQERISR----YQGVNLYIKNLDDTIDDEKLRKEFSPFGS------ITSAKVMLE--- 328
Query: 531 VHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKEL 590
G+S G+ F F E A KA+ +N I G + ++ RK +
Sbjct: 329 -----DGRSKGFGFVCFSSPEEATKAVTEMNG--RIVGSKPLYVALAQRKEERKAHLTNQ 381
Query: 591 RIQRSLQKMRSKPATGEPQKGQPE------PAKDQQQKAAQHHTEEQ-SKVPPEQKRKAG 643
+QR + MR+ PA + QP PA Q Q ++T Q +++ P + + G
Sbjct: 382 YMQR-VAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQG 440
Query: 644 STSWTGFQ 651
GFQ
Sbjct: 441 GRP-QGFQ 447
>gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens]
Length = 636
Score = 75.9 bits (185), Expect = 1e-13
Identities = 57/188 (30%), Positives = 88/188 (46%), Gaps = 20/188 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVT-EKGSKACRGFGYVTFSMLEDVQRALKE 64
+F+ L S ++ L + FS G + C VV E GSK G+G+V F E +RA+++
Sbjct: 101 IFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSK---GYGFVHFETQEAAERAIEK 157
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ V V + K R KE +A+ A + + I+N
Sbjct: 158 MNGMLLNDRKVFVGRFKSR----------------KEREAELGARAKEFTNVYIKNFGED 201
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ LK +F +FG L V + GK +GFGFV F+ +A KA+ MN KE+ G+ +
Sbjct: 202 MDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQI 261
Query: 185 AVDWAVAK 192
V A K
Sbjct: 262 YVGRAQKK 269
Score = 74.3 bits (181), Expect = 4e-13
Identities = 54/179 (30%), Positives = 97/179 (54%), Gaps = 12/179 (6%)
Query: 18 EQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFE--GCKINV 75
E+L++LF + GP V+T++ K+ +GFG+V+F ED Q+A+ E+ E G +I V
Sbjct: 205 ERLKDLFGKFGPALSVKVMTDESGKS-KGFGFVSFERHEDAQKAVDEMNGKELNGKQIYV 263
Query: 76 TVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFA 135
A+KK+ +T+ K K E K+ + + + + L ++NL ++ L+ F+
Sbjct: 264 GRAQKKVERQTELKRKFEQM----KQDRITRYQGVN----LYVKNLDDGIDDERLRKEFS 315
Query: 136 QFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDK 194
FG + + + G+ +GFGFV F + EA KA+ MN + + + + V A K++
Sbjct: 316 PFGTITSAKVMME-GGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEE 373
Score = 69.3 bits (168), Expect = 1e-11
Identities = 94/455 (20%), Positives = 180/455 (39%), Gaps = 84/455 (18%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L P L E FS GP+ V + ++ G+ YV F D +RAL
Sbjct: 12 SLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK +++P +K+ V + + I+NL
Sbjct: 72 M------------------NFDVIKGKPVRIMWSQRDPSLRKSGVGN----IFIKNLDKS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + +G +G+GFV F+ A +A++ MN + R V
Sbjct: 110 IDNKALYDTFSAFGNILSCKVVCDENGS-KGYGFVHFETQEAAERAIEKMNGMLLNDRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G KS + + E + + +E ++ + +D DD+ +D
Sbjct: 169 FV------------------GRFKSRKEREAE-LGARAKEFTNVYIKNFGEDMDDERLKD 209
Query: 245 --GVFDD----EDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSID- 297
G F + +E+ +SK V ++ H + ++E + +
Sbjct: 210 LFGKFGPALSVKVMTDESGKSKGFGFVSFER-------------HEDAQKAVDEMNGKEL 256
Query: 298 DGEEL--AQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELL 355
+G+++ ++ E Q + + K+ ++ +G ++++NL ++E L +
Sbjct: 257 NGKQIYVGRAQKKVERQTELKRKFEQMKQDRITR--YQGVNLYVKNLDDGIDDERLRKEF 314
Query: 356 QQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVD 415
FG + ++++ + SKG F F + E A K + +++GR
Sbjct: 315 SPFGTITSAKVMM--EGGRSKGFGFVCFSSPEEATKAV-----------TEMNGR----- 356
Query: 416 LAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRA 450
+ T+ L K ++ N Y+ R +RA
Sbjct: 357 IVATKPLYVALAQRKEERQAHLTNQYMQRMASVRA 391
Score = 38.5 bits (88), Expect = 0.023
Identities = 66/298 (22%), Positives = 117/298 (39%), Gaps = 58/298 (19%)
Query: 336 TVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLA 395
++++ +L D E L E G + +R+ T S G A+ F A++ L
Sbjct: 12 SLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDT 71
Query: 396 ASPENEAGGLKLDGRQLKV-----DLAVTRDEAAKLQTTKVKKPTGTRNLY--LAREGLI 448
+ + + G+ +++ D ++ + + + K + LY + G I
Sbjct: 72 MNFD------VIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNI 125
Query: 449 RA--------GTKAAEGVSAADMAKRER-FELLKHQKLKDQNIFVSR------------- 486
+ G+K V ER E + L D+ +FV R
Sbjct: 126 LSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGA 185
Query: 487 -----TRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLG 541
T + + N + +DD++L+ L G+ G + +VM D G+S G
Sbjct: 186 RAKEFTNVYIKNFGEDMDDERLKDLF-----GKFGPALS-VKVMTD-------ESGKSKG 232
Query: 542 YAFAEFQEHEHALKALRLIN----NNPEIFGPLKRPIVEFSLEDRRKL-KMKELRIQR 594
+ F F+ HE A KA+ +N N +I+ + VE E +RK +MK+ RI R
Sbjct: 233 FGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITR 290
Score = 35.0 bits (79), Expect = 0.26
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 1/77 (1%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G +L + + R + G+ +V F+ +A +AL
Sbjct: 11 ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALD 70
Query: 173 GMNMKEIKGRTVAVDWA 189
MN IKG+ V + W+
Sbjct: 71 TMNFDVIKGKPVRIMWS 87
>gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens]
Length = 631
Score = 75.5 bits (184), Expect = 2e-13
Identities = 54/179 (30%), Positives = 97/179 (54%), Gaps = 12/179 (6%)
Query: 18 EQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFE--GCKINV 75
E+L++LF + GP V+T++ K+ +GFG+V+F ED Q+A+ E+ E G +I V
Sbjct: 205 ERLKDLFGKFGPALSVKVMTDESGKS-KGFGFVSFERHEDAQKAVDEMNGKELNGKQIYV 263
Query: 76 TVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFA 135
A+KK+ +T+ K E K+ + + +V + L ++NL ++ L+ F+
Sbjct: 264 GRAQKKVERQTELKRTFEQM----KQDRITRYQVVN----LYVKNLDDGIDDERLRKAFS 315
Query: 136 QFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDK 194
FG + + + G+ +GFGFV F + EA KA+ MN + + + + V A K++
Sbjct: 316 PFGTITSAKVMME-GGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEE 373
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/188 (30%), Positives = 90/188 (47%), Gaps = 20/188 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVT-EKGSKACRGFGYVTFSMLEDVQRALKE 64
+FV L S ++ L + S G + C VV E GSK G+G+V F E +RA+K+
Sbjct: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK---GYGFVHFETHEAAERAIKK 157
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ G +N +K + K + KE +A+ A + + I+N
Sbjct: 158 MN---GMLLN---GRKVFVGQFKSR----------KEREAELGARAKEFPNVYIKNFGED 201
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ LK +F +FG L V + GK +GFGFV F+ +A KA+ MN KE+ G+ +
Sbjct: 202 MDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQI 261
Query: 185 AVDWAVAK 192
V A K
Sbjct: 262 YVGRAQKK 269
Score = 66.2 bits (160), Expect = 1e-10
Identities = 94/455 (20%), Positives = 179/455 (39%), Gaps = 84/455 (18%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L P L E FS GP+ + + + + YV F +D + AL
Sbjct: 12 SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK +++P +K+ V + + ++NL
Sbjct: 72 M------------------NFDVIKGKPVRIMWSQRDPSLRKSGVGN----IFVKNLDKS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
+ L + FG +L N+ +G +G+GFV F+ A +A+K MN + GR V
Sbjct: 110 INNKALYDTVSAFGNILSCNVVCDENGS-KGYGFVHFETHEAAERAIKKMNGMLLNGRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G+ KS + + E + + +E ++ + +D DD+ +D
Sbjct: 169 FV------------------GQFKSRKEREAE-LGARAKEFPNVYIKNFGEDMDDERLKD 209
Query: 245 --GVFDD----EDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSID- 297
G F + +E+ +SK V ++ H + ++E + +
Sbjct: 210 LFGKFGPALSVKVMTDESGKSKGFGFVSFER-------------HEDAQKAVDEMNGKEL 256
Query: 298 DGEEL--AQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELL 355
+G+++ ++ E Q + K+ ++ + ++++NL ++E L +
Sbjct: 257 NGKQIYVGRAQKKVERQTELKRTFEQMKQDRITR--YQVVNLYVKNLDDGIDDERLRKAF 314
Query: 356 QQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVD 415
FG + ++++ + SKG F F + E A K + E G + + L V
Sbjct: 315 SPFGTITSAKVMM--EGGRSKGFGFVCFSSPEEATKAV------TEMNGRIVATKPLYVA 366
Query: 416 LAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRA 450
LA ++E T N Y+ R +RA
Sbjct: 367 LAQRKEERQAYLT----------NEYMQRMASVRA 391
Score = 41.6 bits (96), Expect = 0.003
Identities = 61/263 (23%), Positives = 102/263 (38%), Gaps = 78/263 (29%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAA 396
+F++NL + L + + FG + +V D SKG F F T EAA++ +
Sbjct: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVC--DENGSKGYGFVHFETHEAAERAI--- 155
Query: 397 SPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAE 456
+ G+ L+GR++ V +R E RE + A K
Sbjct: 156 ---KKMNGMLLNGRKVFVGQFKSRKE---------------------REAELGARAK--- 188
Query: 457 GVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKG 516
+ N+++ N + +DD++L+ L G+ G
Sbjct: 189 ---------------------EFPNVYIK-------NFGEDMDDERLKDLF-----GKFG 215
Query: 517 VRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLIN----NNPEIFGPLKR 572
+ +VM D G+S G+ F F+ HE A KA+ +N N +I+ +
Sbjct: 216 PALS-VKVMTD-------ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQ 267
Query: 573 PIVEFSLEDRRKL-KMKELRIQR 594
VE E +R +MK+ RI R
Sbjct: 268 KKVERQTELKRTFEQMKQDRITR 290
Score = 32.0 bits (71), Expect = 2.2
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G +L + I R + +V F++ +A AL
Sbjct: 11 ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALD 70
Query: 173 GMNMKEIKGRTVAVDWA 189
MN IKG+ V + W+
Sbjct: 71 TMNFDVIKGKPVRIMWS 87
>gi|185135971 poly(A)-binding protein, cytoplasmic 1-like [Homo
sapiens]
Length = 614
Score = 72.8 bits (177), Expect = 1e-12
Identities = 55/177 (31%), Positives = 83/177 (46%), Gaps = 18/177 (10%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
+F+ L S ++ L + FS G + C V ++ RGFG+V F E Q+A I
Sbjct: 101 IFIKNLEDSIDNKALYDTFSTFGNILSCKVACDEHGS--RGFGFVHFETHEAAQQA---I 155
Query: 66 TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKC 125
T G +N +K K + +E +A+ A + + ++NL
Sbjct: 156 NTMNGMLLN---DRKVFVGHFKSR----------REREAELGARALEFTNIYVKNLPVDV 202
Query: 126 SEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGR 182
E L+ +F+QFG +L V + R G R FGFV F+ EA KA+ MN KE+ GR
Sbjct: 203 DEQGLQDLFSQFGKMLSVKVMRDNSGHSRCFGFVNFEKHEEAQKAVVHMNGKEVSGR 259
Score = 64.7 bits (156), Expect = 3e-10
Identities = 91/436 (20%), Positives = 162/436 (37%), Gaps = 62/436 (14%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L P L E FS GP+ V + ++ G+ Y+ F D +RAL
Sbjct: 12 SLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQQPADAERALDT 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KG+ +++P +K+ V + + I+NL
Sbjct: 72 M------------------NFEMLKGQPIRIMWSQRDPGLRKSGVGN----IFIKNLEDS 109
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + G RGFGFV F+ A +A+ MN + R V
Sbjct: 110 IDNKALYDTFSTFGNILSCKVACDEHGS-RGFGFVHFETHEAAQQAINTMNGMLLNDRKV 168
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G KS + E + + E ++ + D D E
Sbjct: 169 FV------------------GHFKSRREREAE-LGARALEFTNIYVKNLPVDVD----EQ 205
Query: 245 GVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGEEL-- 302
G+ D + + + KV + R H E + + + L
Sbjct: 206 GLQDLFSQFGKMLSVKVMRDNSGHSRCF---GFVNFEKHEEAQKAVVHMNGKEVSGRLLY 262
Query: 303 -AQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGEL 361
++ E Q + + K+ +L +G ++++NL ++++L + +G +
Sbjct: 263 AGRAQKRVERQNELKRRFEQMKQDRLRR--YQGVNLYVKNLDDSIDDDKLRKEFSPYGVI 320
Query: 362 KYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRD 421
+++ + HSKG F F + E A K + E G + + L V LA ++
Sbjct: 321 TSAKVM--TEGGHSKGFGFVCFSSPEEATKAV------TEMNGRIVGTKPLYVALAQRKE 372
Query: 422 EAAKLQTTKVKKPTGT 437
E + T + + T
Sbjct: 373 ERKAILTNQYMQRLST 388
Score = 52.0 bits (123), Expect = 2e-06
Identities = 71/302 (23%), Positives = 115/302 (38%), Gaps = 69/302 (22%)
Query: 314 DKAVQVSNKKKRK-----LPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVL 368
D+ V V + K R+ L + E ++++NL D +E+ L +L QFG++ V+ V+
Sbjct: 165 DRKVFVGHFKSRREREAELGARALEFTNIYVKNLPVDVDEQGLQDLFSQFGKMLSVK-VM 223
Query: 369 HPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQT 428
++ HS+ F F E AQK ++ + + +G L GR K V R K
Sbjct: 224 RDNSGHSRCFGFVNFEKHEEAQKAVVHMNGKEVSGRLLYAGRAQK---RVERQNELK--- 277
Query: 429 TKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTR 488
RFE +K +L+
Sbjct: 278 --------------------------------------RRFEQMKQDRLRR----YQGVN 295
Query: 489 LCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQ 548
L + NL ++DD +LRK GV I +VM + G S G+ F F
Sbjct: 296 LYVKNLDDSIDDDKLRK-----EFSPYGV-ITSAKVMTE--------GGHSKGFGFVCFS 341
Query: 549 EHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMRSKPATGEP 608
E A KA+ +N PL + + E+R+ + + + S + S P G
Sbjct: 342 SPEEATKAVTEMNGRIVGTKPLYVALAQ-RKEERKAILTNQYMQRLSTMRTLSNPLLGSF 400
Query: 609 QK 610
Q+
Sbjct: 401 QQ 402
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 4/85 (4%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G+ L+V L S ++L + FS G + V+TE G +GFG+V FS E+ +A+
Sbjct: 293 GVNLYVKNLDDSIDDDKLRKEFSPYGVITSAKVMTEGGHS--KGFGFVCFSSPEEATKAV 350
Query: 63 KEIT-TFEGCK-INVTVAKKKLRNK 85
E+ G K + V +A++K K
Sbjct: 351 TEMNGRIVGTKPLYVALAQRKEERK 375
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/77 (24%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 114 ARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRK-PDGKMRGFGFVQFKNLLEAGKALK 172
A L + +L +E L F+ G +L + + R + G+ ++ F+ +A +AL
Sbjct: 11 ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQQPADAERALD 70
Query: 173 GMNMKEIKGRTVAVDWA 189
MN + +KG+ + + W+
Sbjct: 71 TMNFEMLKGQPIRIMWS 87
>gi|228008398 synaptotagmin binding, cytoplasmic RNA interacting
protein isoform 3 [Homo sapiens]
Length = 527
Score = 70.9 bits (172), Expect = 4e-12
Identities = 58/223 (26%), Positives = 105/223 (47%), Gaps = 38/223 (17%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G +FVG++P ++L LF + GP+ ++ + + RG+ +VTF E Q A+
Sbjct: 161 GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAV 220
Query: 63 K-----EITTFEGCKINVTVAKKKL------RNKTKEKGKNENSECPK--------KEPK 103
K EI + + + ++VA +L ++KTKE+ E S+ + +P
Sbjct: 221 KLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPD 280
Query: 104 AKKA------------KVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDG 151
KK K A + L +RNL+ +E+ L+ F+QFG + V
Sbjct: 281 DKKKNRGFCFLEYEDHKTAAQVKVLFVRNLANTVTEEILEKAFSQFGKLERVK------- 333
Query: 152 KMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDK 194
K++ + F+ F A KA++ MN K+++G + + +A D+
Sbjct: 334 KLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQ 376
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/272 (21%), Positives = 104/272 (38%), Gaps = 50/272 (18%)
Query: 334 GKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCL 393
G +F+ + D E+EL L ++ G + +R+++ P T ++G AF F T+EAAQ+ +
Sbjct: 161 GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAV 220
Query: 394 LAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTK 453
+ G+ + V ++V + K K +E ++ +K
Sbjct: 221 KLYNNHEIR-----SGKHIGVCISVANNRLFVGSIPKSK----------TKEQILEEFSK 265
Query: 454 AAEGVSAA-------DMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKL 506
EG++ D K F L+++ D L + NL V ++ L K
Sbjct: 266 VTEGLTDVILYHQPDDKKKNRGFCFLEYE---DHKTAAQVKVLFVRNLANTVTEEILEKA 322
Query: 507 LLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEI 566
E+ ++K+ YAF F E + A+KA+ +N
Sbjct: 323 FSQFGKLERVKKLKD--------------------YAFIHFDERDGAVKAMEEMNGK--- 359
Query: 567 FGPLKRPIVEFSLEDRRKLKMKELRIQRSLQK 598
L+ +E K KE + QR K
Sbjct: 360 --DLEGENIEIVFAKPPDQKRKERKAQRQAAK 389
>gi|228008295 synaptotagmin binding, cytoplasmic RNA interacting
protein isoform 4 [Homo sapiens]
Length = 588
Score = 70.9 bits (172), Expect = 4e-12
Identities = 58/223 (26%), Positives = 105/223 (47%), Gaps = 38/223 (17%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G +FVG++P ++L LF + GP+ ++ + + RG+ +VTF E Q A+
Sbjct: 161 GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAV 220
Query: 63 K-----EITTFEGCKINVTVAKKKL------RNKTKEKGKNENSECPK--------KEPK 103
K EI + + + ++VA +L ++KTKE+ E S+ + +P
Sbjct: 221 KLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPD 280
Query: 104 AKKA------------KVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDG 151
KK K A + L +RNL+ +E+ L+ F+QFG + V
Sbjct: 281 DKKKNRGFCFLEYEDHKTAAQVKVLFVRNLANTVTEEILEKAFSQFGKLERVK------- 333
Query: 152 KMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDK 194
K++ + F+ F A KA++ MN K+++G + + +A D+
Sbjct: 334 KLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQ 376
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/272 (21%), Positives = 104/272 (38%), Gaps = 50/272 (18%)
Query: 334 GKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCL 393
G +F+ + D E+EL L ++ G + +R+++ P T ++G AF F T+EAAQ+ +
Sbjct: 161 GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAV 220
Query: 394 LAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTK 453
+ G+ + V ++V + K K +E ++ +K
Sbjct: 221 KLYNNHEIR-----SGKHIGVCISVANNRLFVGSIPKSK----------TKEQILEEFSK 265
Query: 454 AAEGVSAA-------DMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKL 506
EG++ D K F L+++ D L + NL V ++ L K
Sbjct: 266 VTEGLTDVILYHQPDDKKKNRGFCFLEYE---DHKTAAQVKVLFVRNLANTVTEEILEKA 322
Query: 507 LLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEI 566
E+ ++K+ YAF F E + A+KA+ +N
Sbjct: 323 FSQFGKLERVKKLKD--------------------YAFIHFDERDGAVKAMEEMNGK--- 359
Query: 567 FGPLKRPIVEFSLEDRRKLKMKELRIQRSLQK 598
L+ +E K KE + QR K
Sbjct: 360 --DLEGENIEIVFAKPPDQKRKERKAQRQAAK 389
>gi|134152719 CUG triplet repeat, RNA binding protein 2 isoform 4
[Homo sapiens]
Length = 488
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P S ++L+ELF G V Q V+ ++ SK C + T +
Sbjct: 16 IKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 75
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL I T G + + K K V D+K L I
Sbjct: 76 QNALHNIKTLPGMHHPIQM---------------------KPADSEKSNAVEDRK--LFI 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 113 GMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQ 172
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 329 SDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
S+ E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+
Sbjct: 102 SNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPD-GLSRGCAFVTFSTRAM 160
Query: 389 AQKCLLA 395
AQ + A
Sbjct: 161 AQNAIKA 167
Score = 37.7 bits (86), Expect = 0.040
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTFS M ++ +A+
Sbjct: 110 LFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLS-RGCAFVTFSTRAMAQNAIKAM 168
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 169 HQSQTMEGCSSPIVV---KFADTQKDK 192
Score = 34.3 bits (77), Expect = 0.44
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 99 KKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFG 157
+++ A K + A L I +L + + D+ +F FG V+ + K + FG
Sbjct: 388 QQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFG 447
Query: 158 FVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
FV + N + A A++ MN +I + + V +K+ K
Sbjct: 448 FVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSK 486
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/85 (23%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + + ++F G V V +K + + FG+V++ Q A+
Sbjct: 402 GANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 461
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 462 QAMNGFQIGMKRLKVQLKRSKNDSK 486
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E+EL EL + +G + + ++ + SKGC F F T++AA
Sbjct: 18 MFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAA 72
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + ++++ ++ FG + ++ + T SK F + +AQ
Sbjct: 401 EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 460
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ A + G ++ ++LKV L +++++
Sbjct: 461 IQAMN------GFQIGMKRLKVQLKRSKNDS 485
>gi|68303645 CUG triplet repeat, RNA binding protein 2 isoform 1
[Homo sapiens]
Length = 490
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P S ++L+ELF G V Q V+ ++ SK C + T +
Sbjct: 16 IKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 75
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL I T G + + K K V D+K L I
Sbjct: 76 QNALHNIKTLPGMHHPIQM---------------------KPADSEKSNAVEDRK--LFI 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 113 GMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQ 172
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 329 SDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
S+ E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+
Sbjct: 102 SNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPD-GLSRGCAFVTFSTRAM 160
Query: 389 AQKCLLA 395
AQ + A
Sbjct: 161 AQNAIKA 167
Score = 37.7 bits (86), Expect = 0.040
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTFS M ++ +A+
Sbjct: 110 LFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLS-RGCAFVTFSTRAMAQNAIKAM 168
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 169 HQSQTMEGCSSPIVV---KFADTQKDK 192
Score = 34.3 bits (77), Expect = 0.44
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 99 KKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFG 157
+++ A K + A L I +L + + D+ +F FG V+ + K + FG
Sbjct: 390 QQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFG 449
Query: 158 FVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
FV + N + A A++ MN +I + + V +K+ K
Sbjct: 450 FVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSK 488
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/85 (23%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + + ++F G V V +K + + FG+V++ Q A+
Sbjct: 404 GANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 463
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 464 QAMNGFQIGMKRLKVQLKRSKNDSK 488
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E+EL EL + +G + + ++ + SKGC F F T++AA
Sbjct: 18 MFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAA 72
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + ++++ ++ FG + ++ + T SK F + +AQ
Sbjct: 403 EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 462
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ A + G ++ ++LKV L +++++
Sbjct: 463 IQAMN------GFQIGMKRLKVQLKRSKNDS 487
>gi|134152680 CUG triplet repeat, RNA binding protein 2 isoform 2
[Homo sapiens]
Length = 521
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P S ++L+ELF G V Q V+ ++ SK C + T +
Sbjct: 47 IKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 106
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL I T G + + K K V D+K L I
Sbjct: 107 QNALHNIKTLPGMHHPIQM---------------------KPADSEKSNAVEDRK--LFI 143
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 144 GMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQ 203
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 329 SDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
S+ E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+
Sbjct: 133 SNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPD-GLSRGCAFVTFSTRAM 191
Query: 389 AQKCLLA 395
AQ + A
Sbjct: 192 AQNAIKA 198
Score = 37.7 bits (86), Expect = 0.040
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTFS M ++ +A+
Sbjct: 141 LFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLS-RGCAFVTFSTRAMAQNAIKAM 199
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 200 HQSQTMEGCSSPIVV---KFADTQKDK 223
Score = 34.3 bits (77), Expect = 0.44
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 99 KKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFG 157
+++ A K + A L I +L + + D+ +F FG V+ + K + FG
Sbjct: 421 QQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFG 480
Query: 158 FVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
FV + N + A A++ MN +I + + V +K+ K
Sbjct: 481 FVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSK 519
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/85 (23%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + + ++F G V V +K + + FG+V++ Q A+
Sbjct: 435 GANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 494
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 495 QAMNGFQIGMKRLKVQLKRSKNDSK 519
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E+EL EL + +G + + ++ + SKGC F F T++AA
Sbjct: 49 MFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAA 103
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + ++++ ++ FG + ++ + T SK F + +AQ
Sbjct: 434 EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 493
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ A + G ++ ++LKV L +++++
Sbjct: 494 IQAMN------GFQIGMKRLKVQLKRSKNDS 518
>gi|68303647 CUG triplet repeat, RNA binding protein 2 isoform 3
[Homo sapiens]
Length = 508
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P S ++L+ELF G V Q V+ ++ SK C + T +
Sbjct: 40 IKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 99
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL I T G + + K K V D+K L I
Sbjct: 100 QNALHNIKTLPGMHHPIQM---------------------KPADSEKSNAVEDRK--LFI 136
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 137 GMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQ 196
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 329 SDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
S+ E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+
Sbjct: 126 SNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPD-GLSRGCAFVTFSTRAM 184
Query: 389 AQKCLLA 395
AQ + A
Sbjct: 185 AQNAIKA 191
Score = 37.7 bits (86), Expect = 0.040
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTFS M ++ +A+
Sbjct: 134 LFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLS-RGCAFVTFSTRAMAQNAIKAM 192
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 193 HQSQTMEGCSSPIVV---KFADTQKDK 216
Score = 34.3 bits (77), Expect = 0.44
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 99 KKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFG 157
+++ A K + A L I +L + + D+ +F FG V+ + K + FG
Sbjct: 408 QQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFG 467
Query: 158 FVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
FV + N + A A++ MN +I + + V +K+ K
Sbjct: 468 FVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSK 506
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/85 (23%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + + ++F G V V +K + + FG+V++ Q A+
Sbjct: 422 GANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 481
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 482 QAMNGFQIGMKRLKVQLKRSKNDSK 506
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E+EL EL + +G + + ++ + SKGC F F T++AA
Sbjct: 42 MFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAA 96
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + ++++ ++ FG + ++ + T SK F + +AQ
Sbjct: 421 EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 480
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ A + G ++ ++LKV L +++++
Sbjct: 481 IQAMN------GFQIGMKRLKVQLKRSKNDS 505
>gi|86991440 splicing factor, arginine/serine-rich 5 [Homo sapiens]
Length = 272
Score = 70.9 bits (172), Expect = 4e-12
Identities = 52/187 (27%), Positives = 86/187 (45%), Gaps = 14/187 (7%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR 60
M+G +F+GRL P+AR + +E F G ++ + RGFG+V F D
Sbjct: 1 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--------RGFGFVEFEDPRDADD 52
Query: 61 ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPK--AKKAKVADKKARLII 118
A+ E+ E C VT+ + R++ + + P+ + A + RLI+
Sbjct: 53 AVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIV 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAV--LEVNIPRKPDGKMRGFGFVQFKNLLE--AGKALKGM 174
NLS + S DLK Q G V + + P+ +G + + KN +E +GK + G
Sbjct: 113 ENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGR 172
Query: 175 NMKEIKG 181
+K I+G
Sbjct: 173 KIKLIEG 179
Score = 37.4 bits (85), Expect = 0.052
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 7/80 (8%)
Query: 115 RLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGM 174
R+ I L+ E D++ F +G + ++++ R GFGFV+F++ +A A+ +
Sbjct: 5 RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKR-------GFGFVEFEDPRDADDAVYEL 57
Query: 175 NMKEIKGRTVAVDWAVAKDK 194
+ KE+ V ++ A A+ +
Sbjct: 58 DGKELCSERVTIEHARARSR 77
>gi|86991438 splicing factor, arginine/serine-rich 5 [Homo sapiens]
Length = 272
Score = 70.9 bits (172), Expect = 4e-12
Identities = 52/187 (27%), Positives = 86/187 (45%), Gaps = 14/187 (7%)
Query: 1 MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR 60
M+G +F+GRL P+AR + +E F G ++ + RGFG+V F D
Sbjct: 1 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--------RGFGFVEFEDPRDADD 52
Query: 61 ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPK--AKKAKVADKKARLII 118
A+ E+ E C VT+ + R++ + + P+ + A + RLI+
Sbjct: 53 AVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIV 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAV--LEVNIPRKPDGKMRGFGFVQFKNLLE--AGKALKGM 174
NLS + S DLK Q G V + + P+ +G + + KN +E +GK + G
Sbjct: 113 ENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGR 172
Query: 175 NMKEIKG 181
+K I+G
Sbjct: 173 KIKLIEG 179
Score = 37.4 bits (85), Expect = 0.052
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 7/80 (8%)
Query: 115 RLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGM 174
R+ I L+ E D++ F +G + ++++ R GFGFV+F++ +A A+ +
Sbjct: 5 RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKR-------GFGFVEFEDPRDADDAVYEL 57
Query: 175 NMKEIKGRTVAVDWAVAKDK 194
+ KE+ V ++ A A+ +
Sbjct: 58 DGKELCSERVTIEHARARSR 77
>gi|168229150 poly(A) binding protein, cytoplasmic 4-like [Homo
sapiens]
Length = 370
Score = 70.9 bits (172), Expect = 4e-12
Identities = 92/424 (21%), Positives = 164/424 (38%), Gaps = 78/424 (18%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
+L+VG L + L FS VGPV + ++ ++ G+ YV F L D Q+AL
Sbjct: 11 SLYVGDLHADVTEDLLFRKFSTVGPVLSIRICRDQVTRRSLGYAYVNFLQLADAQKALDT 70
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ N KGK+ +++ +++ + + + I+NL
Sbjct: 71 M------------------NFDIIKGKSIRLMWSQRDAYLRRSGIGN----VFIKNLDKS 108
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
L F+ FG +L + G +G+ FV F+N A +A++ MN K +KG V
Sbjct: 109 IDNKTLYEHFSAFGKILSSKVMSDDQGS-KGYAFVHFQNQSAADRAIEEMNGKLLKGCKV 167
Query: 185 AVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEED 244
V G K+ + + E ++ K E ++ + D D
Sbjct: 168 FV------------------GRFKNRKDREAE-LRSKASEFTNVYIKNFGGDMD------ 202
Query: 245 GVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKS--------SDHSEEDSDLEESDSI 296
DE +++ SK K + ++ V + KS H +EE +
Sbjct: 203 ------DERLKDVFSKYGKTLSVK---VMTDSSGKSKGFGFVSFDSHEAAKKAVEEMNGR 253
Query: 297 DDGEEL---AQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGE 353
D +L ++ E Q + K+ ++ +G ++I+NL ++E+L
Sbjct: 254 DINGQLIFVGRAQKKVERQAELKQMFEQLKRERIRG--CQGVKLYIKNLDDTIDDEKLRN 311
Query: 354 LLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLK 413
FG + V+++ + SKG F + E A K + E G L + L
Sbjct: 312 EFSSFGSISRVKVM--QEEGQSKGFGLICFSSPEDATKAM------TEMNGRILGSKPLS 363
Query: 414 VDLA 417
+ LA
Sbjct: 364 IALA 367
Score = 48.9 bits (115), Expect = 2e-05
Identities = 62/267 (23%), Positives = 108/267 (40%), Gaps = 73/267 (27%)
Query: 305 SDTSTEEQEDKAVQ--------VSNKKKRK--LPSDVNEGKTVFIRNLSFDSEEEELGEL 354
+D + EE K ++ N+K R+ L S +E V+I+N D ++E L ++
Sbjct: 150 ADRAIEEMNGKLLKGCKVFVGRFKNRKDREAELRSKASEFTNVYIKNFGGDMDDERLKDV 209
Query: 355 LQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKV 414
++G+ V+ V+ + SKG F F + EAA+K + E G ++G+ + V
Sbjct: 210 FSKYGKTLSVK-VMTDSSGKSKGFGFVSFDSHEAAKKAV------EEMNGRDINGQLIFV 262
Query: 415 DLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKH 474
A + E + AE ++ FE LK
Sbjct: 263 GRAQKKVE------------------------------RQAE--------LKQMFEQLKR 284
Query: 475 QKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGN 534
++++ +L + NL +DD++LR S S I +VM++
Sbjct: 285 ERIRG----CQGVKLYIKNLDDTIDDEKLRNEFSSFGS------ISRVKVMQE------- 327
Query: 535 MKGQSLGYAFAEFQEHEHALKALRLIN 561
+GQS G+ F E A KA+ +N
Sbjct: 328 -EGQSKGFGLICFSSPEDATKAMTEMN 353
>gi|77695912 TIA-1 related protein isoform 2 [Homo sapiens]
Length = 392
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/189 (28%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
TL+VG L + +LFSQ+GP K C ++TE+ R V FS+L+
Sbjct: 10 TLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSR-RVNSSVGFSVLQHTSN--DP 66
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
E + A N K GK KK + + +LS +
Sbjct: 67 YCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKD--TSNHFHVFVGDLSPE 124
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRK-PDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+ +D+K+ FA FG + + + + GK +G+GFV F N L+A A+ M + + GR
Sbjct: 125 ITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQ 184
Query: 184 VAVDWAVAK 192
+ +WA K
Sbjct: 185 IRTNWATRK 193
Score = 51.6 bits (122), Expect = 3e-06
Identities = 48/207 (23%), Positives = 87/207 (42%), Gaps = 28/207 (13%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
+FVG L P +E ++ F+ G + VV + + +G+G+V+F D + A+ +
Sbjct: 116 VFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHM 175
Query: 66 --TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSF 123
G +I A +K K EN+ K+ + D + +N +
Sbjct: 176 GGQWLGGRQIRTNWATRK---PPAPKSTQENN--------TKQLRFEDVVNQSSPKNCTV 224
Query: 124 KC-------SEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFGFVQFKNLLEAGKALKGMN 175
C ++ ++ F+ FG ++E+ + P K G+ FV+F A A+ +N
Sbjct: 225 YCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK------GYSFVRFSTHESAAHAIVSVN 278
Query: 176 MKEIKGRTVAVDWA-VAKDKYKDTQSV 201
I+G V W + D K+ Q V
Sbjct: 279 GTTIEGHVVKCYWGKESPDMTKNFQQV 305
Score = 38.9 bits (89), Expect = 0.018
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 11/110 (10%)
Query: 316 AVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHS 375
A S++KK D + VF+ +LS + E++ FG++ R+V T S
Sbjct: 100 ATTPSSQKK-----DTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKS 154
Query: 376 KGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
KG F F + A+ ++ GG L GRQ++ + A + A K
Sbjct: 155 KGYGFVSFYNKLDAENAIV------HMGGQWLGGRQIRTNWATRKPPAPK 198
Score = 35.4 bits (80), Expect = 0.20
Identities = 64/327 (19%), Positives = 115/327 (35%), Gaps = 78/327 (23%)
Query: 116 LIIRNLSFKCSEDDLKTVFAQFGAVLEVN-IPRKPDGKMR----GFG-----------FV 159
L + NLS +E + +F+Q G I +PD + GF FV
Sbjct: 11 LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFV 70
Query: 160 QFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVK 219
+F +A AL MN ++I G+ V V+WA +K S H
Sbjct: 71 EFYEHRDAAAALAAMNGRKILGKEVKVNWATTP------------SSQKKDTSNHFHVF- 117
Query: 220 KKGREEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAK 279
D+ E +D G D R VK A K
Sbjct: 118 -----VGDLSPEITTEDIKSAFAPFGKISD-------------------ARVVKDMATGK 153
Query: 280 SSDH---------SEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSD 330
S + E++ + G ++ + + + K+ Q +N K+ +
Sbjct: 154 SKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDV 213
Query: 331 VNEGK----TVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQ 386
VN+ TV+ ++ ++ + + FG++ +R+ KG +F +F T
Sbjct: 214 VNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVF------PEKGYSFVRFSTH 267
Query: 387 EAAQKCLLAASPENEAGGLKLDGRQLK 413
E+A +++ + G ++G +K
Sbjct: 268 ESAAHAIVSVN------GTTIEGHVVK 288
>gi|4507499 TIA-1 related protein isoform 1 [Homo sapiens]
Length = 375
Score = 68.2 bits (165), Expect = 3e-11
Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 23/189 (12%)
Query: 5 TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64
TL+VG L + +LFSQ+GP K C ++TE S + +V F D AL
Sbjct: 10 TLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSND--PYCFVEFYEHRDAAAALAA 67
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
+ +K L + K P ++K K + + +LS +
Sbjct: 68 MN-----------GRKILGKEVKVNWATT--------PSSQK-KDTSNHFHVFVGDLSPE 107
Query: 125 CSEDDLKTVFAQFGAVLEVNIPRK-PDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+ +D+K+ FA FG + + + + GK +G+GFV F N L+A A+ M + + GR
Sbjct: 108 ITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQ 167
Query: 184 VAVDWAVAK 192
+ +WA K
Sbjct: 168 IRTNWATRK 176
Score = 51.6 bits (122), Expect = 3e-06
Identities = 48/207 (23%), Positives = 87/207 (42%), Gaps = 28/207 (13%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
+FVG L P +E ++ F+ G + VV + + +G+G+V+F D + A+ +
Sbjct: 99 VFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHM 158
Query: 66 --TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSF 123
G +I A +K K EN+ K+ + D + +N +
Sbjct: 159 GGQWLGGRQIRTNWATRK---PPAPKSTQENN--------TKQLRFEDVVNQSSPKNCTV 207
Query: 124 KC-------SEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFGFVQFKNLLEAGKALKGMN 175
C ++ ++ F+ FG ++E+ + P K G+ FV+F A A+ +N
Sbjct: 208 YCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK------GYSFVRFSTHESAAHAIVSVN 261
Query: 176 MKEIKGRTVAVDWA-VAKDKYKDTQSV 201
I+G V W + D K+ Q V
Sbjct: 262 GTTIEGHVVKCYWGKESPDMTKNFQQV 288
Score = 38.9 bits (89), Expect = 0.018
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 11/110 (10%)
Query: 316 AVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHS 375
A S++KK D + VF+ +LS + E++ FG++ R+V T S
Sbjct: 83 ATTPSSQKK-----DTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKS 137
Query: 376 KGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
KG F F + A+ ++ GG L GRQ++ + A + A K
Sbjct: 138 KGYGFVSFYNKLDAENAIV------HMGGQWLGGRQIRTNWATRKPPAPK 181
Score = 35.8 bits (81), Expect = 0.15
Identities = 59/311 (18%), Positives = 111/311 (35%), Gaps = 63/311 (20%)
Query: 116 LIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMN 175
L + NLS +E + +F+Q G + + + FV+F +A AL MN
Sbjct: 11 LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSN-DPYCFVEFYEHRDAAAALAAMN 69
Query: 176 MKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDD 235
++I G+ V V+WA +K S H D+ E +
Sbjct: 70 GRKILGKEVKVNWATTP------------SSQKKDTSNHFHVF------VGDLSPEITTE 111
Query: 236 DDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDH---------SEE 286
D G D R VK A KS + E
Sbjct: 112 DIKSAFAPFGKISD-------------------ARVVKDMATGKSKGYGFVSFYNKLDAE 152
Query: 287 DSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGK----TVFIRNL 342
++ + G ++ + + + K+ Q +N K+ + VN+ TV+ +
Sbjct: 153 NAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGI 212
Query: 343 SFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEA 402
+ ++ + + FG++ +R+ KG +F +F T E+A +++ +
Sbjct: 213 ASGLTDQLMRQTFSPFGQIMEIRVF------PEKGYSFVRFSTHESAAHAIVSVN----- 261
Query: 403 GGLKLDGRQLK 413
G ++G +K
Sbjct: 262 -GTTIEGHVVK 271
Score = 34.3 bits (77), Expect = 0.44
Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 12/98 (12%)
Query: 330 DVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKG--CAFAQFMTQE 387
D + +T+++ NLS D E + +L Q G K +++ TEH+ F +F
Sbjct: 4 DDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMI----TEHTSNDPYCFVEFYEHR 59
Query: 388 AAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAK 425
A L A + G K+ G+++KV+ A T K
Sbjct: 60 DAAAALAAMN------GRKILGKEVKVNWATTPSSQKK 91
>gi|25470890 DAZ associated protein 1 isoform a [Homo sapiens]
Length = 378
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/190 (28%), Positives = 86/190 (45%), Gaps = 11/190 (5%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL-KE 64
LFVG L S E L FSQ G V C ++ +K + RGFG+V F V L
Sbjct: 12 LFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASR 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
T +G I+ K + + + E +K P++ + K ++ + +
Sbjct: 72 PHTLDGRNID----PKPCTPRGMQPERTRPKEGWQKGPRSDNS----KSNKIFVGGIPHN 123
Query: 125 CSEDDLKTVFAQFGAVLE-VNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
C E +L+ F +FG V E V I + RGFGF+ F++ +A+ M+ +I G+
Sbjct: 124 CGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAV-NMHFHDIMGKK 182
Query: 184 VAVDWAVAKD 193
V V A +D
Sbjct: 183 VEVKRAEPRD 192
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/55 (34%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 110 ADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPR-KPDGKMRGFGFVQFKN 163
AD+ +L + L + +++ L++ F+Q+G V++ I + K + RGFGFV+FK+
Sbjct: 6 ADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKD 60
>gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens]
Length = 407
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/190 (28%), Positives = 86/190 (45%), Gaps = 11/190 (5%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL-KE 64
LFVG L S E L FSQ G V C ++ +K + RGFG+V F V L
Sbjct: 12 LFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASR 71
Query: 65 ITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFK 124
T +G I+ K + + + E +K P++ + K ++ + +
Sbjct: 72 PHTLDGRNID----PKPCTPRGMQPERTRPKEGWQKGPRSDNS----KSNKIFVGGIPHN 123
Query: 125 CSEDDLKTVFAQFGAVLE-VNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
C E +L+ F +FG V E V I + RGFGF+ F++ +A+ M+ +I G+
Sbjct: 124 CGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAV-NMHFHDIMGKK 182
Query: 184 VAVDWAVAKD 193
V V A +D
Sbjct: 183 VEVKRAEPRD 192
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/55 (34%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 110 ADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPR-KPDGKMRGFGFVQFKN 163
AD+ +L + L + +++ L++ F+Q+G V++ I + K + RGFGFV+FK+
Sbjct: 6 ADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKD 60
>gi|115511032 ELAV (embryonic lethal, abnormal vision,
Drosophila)-like 2 (Hu antigen B) [Homo sapiens]
Length = 359
Score = 67.0 bits (162), Expect = 6e-11
Identities = 46/194 (23%), Positives = 89/194 (45%), Gaps = 25/194 (12%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
L V LP + E+L+ LF +G ++ C +V +K + G+G+V + +D ++A I
Sbjct: 41 LIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKA---I 97
Query: 66 TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKC 125
T G ++ K A+ + + + A L + L
Sbjct: 98 NTLNGLRLQTKTIKVSY---------------------ARPSSASIRDANLYVSGLPKTM 136
Query: 126 SEDDLKTVFAQFGAVLEVNI-PRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTV 184
++ +L+ +F+Q+G ++ I + G RG GF++F +EA +A+KG+N ++ G T
Sbjct: 137 TQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATE 196
Query: 185 AVDWAVAKDKYKDT 198
+ A + + T
Sbjct: 197 PITVKFANNPSQKT 210
Score = 51.2 bits (121), Expect = 3e-06
Identities = 70/340 (20%), Positives = 134/340 (39%), Gaps = 42/340 (12%)
Query: 111 DKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPR-KPDGKMRGFGFVQFKNLLEAGK 169
D K LI+ L ++++LK++F G + + R K G+ G+GFV + + +A K
Sbjct: 36 DSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEK 95
Query: 170 ALKGMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDME 229
A+ +N ++ +T+ V +A S ++I + + S +++ +K E+ +
Sbjct: 96 AINTLNGLRLQTKTIKVSYA--------RPSSASIRDANLYVSGLPKTMTQKELEQLFSQ 147
Query: 230 EEENDDDDDDDDEEDGV--------FDDEDEEEENIE--SKVTKPVQIQKRAVKRPAPAK 279
D+ G+ FD E EE I+ + P + VK
Sbjct: 148 YGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPS 207
Query: 280 SSDHSEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKR-------------- 325
+ S L +S + LAQ + + D + ++ KR
Sbjct: 208 QKTNQAILSQLYQSPNRRYPGPLAQQ--AQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAG 265
Query: 326 -KLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFM 384
+P G +F+ NL+ D++E L ++ FG + V+++ +T KG F
Sbjct: 266 INIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMT 325
Query: 385 TQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAA 424
+ A + + + G +L R L+V + A
Sbjct: 326 NYDEAAMAIASLN------GYRLGDRVLQVSFKTNKTHKA 359
Score = 38.5 bits (88), Expect = 0.023
Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 12/77 (15%)
Query: 485 SRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAF 544
S+T L ++ LP+ + ++L+ L S GE I+ C+++RD + GQSLGY F
Sbjct: 37 SKTNLIVNYLPQNMTQEELKSLFGSI--GE----IESCKLVRD------KITGQSLGYGF 84
Query: 545 AEFQEHEHALKALRLIN 561
+ + + A KA+ +N
Sbjct: 85 VNYIDPKDAEKAINTLN 101
Score = 38.5 bits (88), Expect = 0.023
Identities = 18/66 (27%), Positives = 32/66 (48%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G +FV L P A L ++F G V V+ + + C+GFG+VT + ++ A+
Sbjct: 275 GWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAI 334
Query: 63 KEITTF 68
+ +
Sbjct: 335 ASLNGY 340
Score = 34.3 bits (77), Expect = 0.44
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 7/89 (7%)
Query: 330 DVNEGKTVFIRN-LSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEA 388
+ + KT I N L + +EEL L GE++ ++V T S G F ++ +
Sbjct: 33 NTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKD 92
Query: 389 AQKCLLAASPENEAGGLKLDGRQLKVDLA 417
A+K + N GL+L + +KV A
Sbjct: 93 AEKAI------NTLNGLRLQTKTIKVSYA 115
>gi|4505255 musashi 1 [Homo sapiens]
Length = 362
Score = 66.6 bits (161), Expect = 8e-11
Identities = 55/197 (27%), Positives = 89/197 (45%), Gaps = 25/197 (12%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEI 65
+F+G L E L E F Q G VK+C V+ + +K RGFG+VTF V + L +
Sbjct: 22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQ- 80
Query: 66 TTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKE-PKAKKAKVADKKARLIIRNLSFK 124
++ +L +KT + PK P+ + K+ + ++ + LS
Sbjct: 81 ------------SRHELDSKTID---------PKVAFPRRAQPKMVTRTKKIFVGGLSVN 119
Query: 125 CSEDDLKTVFAQFGAVLEVNIP-RKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRT 183
+ +D+K F QFG V + + K + RGFGFV F++ K + ++ EI +
Sbjct: 120 TTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCE-IHFHEINNKM 178
Query: 184 VAVDWAVAKDKYKDTQS 200
V A K+ T S
Sbjct: 179 VECKKAQPKEVMSPTGS 195
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 8/106 (7%)
Query: 328 PSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQE 387
P ++ +FI LS+ + +E L E QFGE+K ++ P T+ S+G F FM Q
Sbjct: 13 PDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQA 72
Query: 388 AAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKK 433
K L + E LD + + +A R K+ T+ KK
Sbjct: 73 GVDKVLAQSRHE-------LDSKTIDPKVAFPRRAQPKM-VTRTKK 110
Score = 39.3 bits (90), Expect = 0.014
Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 2/71 (2%)
Query: 115 RLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKP-DGKMRGFGFVQFKNLLEAGKALKG 173
++ I LS++ +++ L+ F QFG V E + R P + RGFGFV F + K L
Sbjct: 21 KMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVL-A 79
Query: 174 MNMKEIKGRTV 184
+ E+ +T+
Sbjct: 80 QSRHELDSKTI 90
Score = 36.6 bits (83), Expect = 0.089
Identities = 16/68 (23%), Positives = 34/68 (50%)
Query: 324 KRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQF 383
+R P V K +F+ LS ++ E++ + +QFG++ ++ T +G F F
Sbjct: 98 RRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTF 157
Query: 384 MTQEAAQK 391
+++ +K
Sbjct: 158 ESEDIVEK 165
>gi|71164871 CUG triplet repeat, RNA-binding protein 1 isoform 3
[Homo sapiens]
Length = 486
Score = 65.9 bits (159), Expect = 1e-10
Identities = 50/180 (27%), Positives = 77/180 (42%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P + + L ELF Q G V + V+ ++ SK C + T +
Sbjct: 16 IKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 75
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL + G + + K K V D+K L I
Sbjct: 76 QNALHNMKVLPGMHHPIQM---------------------KPADSEKNNAVEDRK--LFI 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 113 GMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQ 172
Score = 37.7 bits (86), Expect = 0.040
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+ AQ
Sbjct: 106 EDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD-GLSRGCAFVTFTTRAMAQTA 164
Query: 393 LLA 395
+ A
Sbjct: 165 IKA 167
Score = 35.8 bits (81), Expect = 0.15
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTF+ M + +A+
Sbjct: 110 LFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLS-RGCAFVTFTTRAMAQTAIKAM 168
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 169 HQAQTMEGCSSPMVV---KFADTQKDK 192
Score = 35.8 bits (81), Expect = 0.15
Identities = 21/85 (24%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + L ++F G V V +K + + FG+V++ Q A+
Sbjct: 400 GANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 459
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 460 QSMNGFQIGMKRLKVQLKRSKNDSK 484
Score = 34.7 bits (78), Expect = 0.34
Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 92 NENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPD 150
N+N + A K + A L I +L + + DL +F FG V+ + K
Sbjct: 379 NQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQT 438
Query: 151 GKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
+ FGFV + N + A A++ MN +I + + V +K+ K
Sbjct: 439 NLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSK 484
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E++L EL +Q+G + + ++ + SKGC F F T++AA
Sbjct: 18 MFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAA 72
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 43/91 (47%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + +++L ++ FG + ++ + T SK F + +AQ
Sbjct: 399 EGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 458
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ G ++ ++LKV L +++++
Sbjct: 459 I------QSMNGFQIGMKRLKVQLKRSKNDS 483
>gi|5729794 CUG triplet repeat, RNA-binding protein 1 isoform 1
[Homo sapiens]
Length = 482
Score = 65.9 bits (159), Expect = 1e-10
Identities = 50/180 (27%), Positives = 77/180 (42%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P + + L ELF Q G V + V+ ++ SK C + T +
Sbjct: 16 IKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 75
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL + G + + K K V D+K L I
Sbjct: 76 QNALHNMKVLPGMHHPIQM---------------------KPADSEKNNAVEDRK--LFI 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 113 GMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQ 172
Score = 37.7 bits (86), Expect = 0.040
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+ AQ
Sbjct: 106 EDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD-GLSRGCAFVTFTTRAMAQTA 164
Query: 393 LLA 395
+ A
Sbjct: 165 IKA 167
Score = 35.8 bits (81), Expect = 0.15
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTF+ M + +A+
Sbjct: 110 LFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLS-RGCAFVTFTTRAMAQTAIKAM 168
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 169 HQAQTMEGCSSPMVV---KFADTQKDK 192
Score = 35.8 bits (81), Expect = 0.15
Identities = 21/85 (24%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + L ++F G V V +K + + FG+V++ Q A+
Sbjct: 396 GANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 455
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 456 QSMNGFQIGMKRLKVQLKRSKNDSK 480
Score = 34.7 bits (78), Expect = 0.34
Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 92 NENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPD 150
N+N + A K + A L I +L + + DL +F FG V+ + K
Sbjct: 375 NQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQT 434
Query: 151 GKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
+ FGFV + N + A A++ MN +I + + V +K+ K
Sbjct: 435 NLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSK 480
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E++L EL +Q+G + + ++ + SKGC F F T++AA
Sbjct: 18 MFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAA 72
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 43/91 (47%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + +++L ++ FG + ++ + T SK F + +AQ
Sbjct: 395 EGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 454
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ G ++ ++LKV L +++++
Sbjct: 455 I------QSMNGFQIGMKRLKVQLKRSKNDS 479
>gi|38570081 CUG triplet repeat, RNA-binding protein 1 isoform 2
[Homo sapiens]
Length = 483
Score = 65.9 bits (159), Expect = 1e-10
Identities = 50/180 (27%), Positives = 77/180 (42%), Gaps = 28/180 (15%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKG-----SKACRGFGYVTFSMLEDV 58
+ +FVG++P + + L ELF Q G V + V+ ++ SK C + T +
Sbjct: 16 IKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEA 75
Query: 59 QRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLII 118
Q AL + G + + K K V D+K L I
Sbjct: 76 QNALHNMKVLPGMHHPIQM---------------------KPADSEKNNAVEDRK--LFI 112
Query: 119 RNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKE 178
+S KC+E+D++ +F+ FG + E I R PDG RG FV F A A+K M+ +
Sbjct: 113 GMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQ 172
Score = 37.7 bits (86), Expect = 0.040
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
E + +FI +S E ++ + FG+++ RI+ PD S+GCAF F T+ AQ
Sbjct: 106 EDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD-GLSRGCAFVTFTTRAMAQTA 164
Query: 393 LLA 395
+ A
Sbjct: 165 IKA 167
Score = 35.8 bits (81), Expect = 0.15
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 7/87 (8%)
Query: 6 LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFS---MLEDVQRAL 62
LF+G + + +FS G +++C ++ + RG +VTF+ M + +A+
Sbjct: 110 LFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLS-RGCAFVTFTTRAMAQTAIKAM 168
Query: 63 KEITTFEGCKINVTVAKKKLRNKTKEK 89
+ T EGC + V K + K+K
Sbjct: 169 HQAQTMEGCSSPMVV---KFADTQKDK 192
Score = 35.8 bits (81), Expect = 0.15
Identities = 21/85 (24%), Positives = 39/85 (45%)
Query: 3 GLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRAL 62
G LF+ LP + L ++F G V V +K + + FG+V++ Q A+
Sbjct: 397 GANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAI 456
Query: 63 KEITTFEGCKINVTVAKKKLRNKTK 87
+ + F+ + V K+ +N +K
Sbjct: 457 QSMNGFQIGMKRLKVQLKRSKNDSK 481
Score = 34.7 bits (78), Expect = 0.34
Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 92 NENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNI-PRKPD 150
N+N + A K + A L I +L + + DL +F FG V+ + K
Sbjct: 376 NQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQT 435
Query: 151 GKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK 196
+ FGFV + N + A A++ MN +I + + V +K+ K
Sbjct: 436 NLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSK 481
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Query: 337 VFIRNLSFDSEEEELGELLQQFGELKYVRIVLH--PDTEHSKGCAFAQFMTQEAA 389
+F+ + E++L EL +Q+G + + ++ + SKGC F F T++AA
Sbjct: 18 MFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAA 72
Score = 31.6 bits (70), Expect = 2.9
Identities = 19/91 (20%), Positives = 43/91 (47%), Gaps = 6/91 (6%)
Query: 333 EGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKC 392
EG +FI +L + +++L ++ FG + ++ + T SK F + +AQ
Sbjct: 396 EGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 455
Query: 393 LLAASPENEAGGLKLDGRQLKVDLAVTRDEA 423
+ G ++ ++LKV L +++++
Sbjct: 456 I------QSMNGFQIGMKRLKVQLKRSKNDS 480
>gi|187761301 bruno-like 4, RNA binding protein isoform 3 [Homo
sapiens]
Length = 484
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/175 (25%), Positives = 82/175 (46%), Gaps = 19/175 (10%)
Query: 4 LTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDV---QR 60
+ LF+G++P + + L+ LF + G + + V+ ++ + +G ++T+ E Q
Sbjct: 54 IKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQS 113
Query: 61 ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN 120
AL E T G + V K + S C ++ P +K L +
Sbjct: 114 ALHEQKTLPGMNRPIQV-------KPADSESRGGSSCLRQPPSHRK---------LFVGM 157
Query: 121 LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMN 175
L+ + SEDD++ +F FG + E I R PDG +G FV++ + EA A+ ++
Sbjct: 158 LNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALH 212
Score = 40.4 bits (93), Expect = 0.006
Identities = 55/282 (19%), Positives = 109/282 (38%), Gaps = 75/282 (26%)
Query: 327 LPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQ 386
+P ++ +FI + + +E++L L ++FG++ + ++ T KGCAF + +
Sbjct: 46 IPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCER 105
Query: 387 EAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREG 446
E+A K A + G+ R ++V A D ++ ++ +++P R L++
Sbjct: 106 ESALKAQSALHEQKTLPGM---NRPIQVKPA---DSESRGGSSCLRQPPSHRKLFVG--- 156
Query: 447 LIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKL 506
+L Q+ +D +R+L
Sbjct: 157 ------------------------MLNKQQSED----------------------DVRRL 170
Query: 507 LLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEI 566
E I+EC ++R G GN K G AF ++ H A A+ ++ + +
Sbjct: 171 F------EAFGNIEECTILR---GPDGNSK----GCAFVKYSSHAEAQAAINALHGSQTM 217
Query: 567 FGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMRSKPATGEP 608
G +V+F+ D+ R R +Q+M + P
Sbjct: 218 PGASSSLVVKFADTDKE-------RTMRRMQQMAGQMGMFNP 252
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,463,920
Number of Sequences: 37866
Number of extensions: 1475800
Number of successful extensions: 33769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 790
Number of HSP's successfully gapped in prelim test: 723
Number of HSP's that attempted gapping in prelim test: 11652
Number of HSP's gapped (non-prelim): 10064
length of query: 759
length of database: 18,247,518
effective HSP length: 110
effective length of query: 649
effective length of database: 14,082,258
effective search space: 9139385442
effective search space used: 9139385442
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.