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Search of human proteins with 11321571
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11321571 slit homolog 3 [Homo sapiens]
(1523 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11321571 slit homolog 3 [Homo sapiens] 3186 0.0
gi|4759146 slit homolog 2 [Homo sapiens] 2197 0.0
gi|188528675 slit homolog 1 [Homo sapiens] 1949 0.0
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 214 5e-55
gi|24041035 notch 2 preproprotein [Homo sapiens] 214 7e-55
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 209 1e-53
gi|148833508 notch1 preproprotein [Homo sapiens] 204 7e-52
gi|134244285 Notch homolog 3 [Homo sapiens] 203 1e-51
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 202 3e-51
gi|4557679 jagged 1 precursor [Homo sapiens] 196 1e-49
gi|55770876 notch4 preproprotein [Homo sapiens] 195 3e-49
gi|112420992 crumbs homolog 2 [Homo sapiens] 194 7e-49
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 191 4e-48
gi|110735443 delta-like 1 [Homo sapiens] 191 6e-48
gi|148886654 polydom [Homo sapiens] 187 7e-47
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 183 1e-45
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 183 1e-45
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 181 4e-45
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 175 3e-43
gi|122937283 6720455I24Rik homolog [Homo sapiens] 171 4e-42
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 164 6e-40
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 157 7e-38
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 157 7e-38
gi|40217825 slit and trk like 6 [Homo sapiens] 154 5e-37
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 149 3e-35
gi|109150416 peroxidasin [Homo sapiens] 142 3e-33
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 138 4e-32
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 138 4e-32
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 138 4e-32
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 137 6e-32
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 3186 bits (8261), Expect = 0.0
Identities = 1523/1523 (100%), Positives = 1523/1523 (100%)
Query: 1 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 60
MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP
Sbjct: 1 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Query: 61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120
RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK
Sbjct: 61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120
Query: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
Query: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240
RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT
Sbjct: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240
Query: 241 LCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME 300
LCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME
Sbjct: 241 LCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME 300
Query: 301 IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL 360
IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL
Sbjct: 301 IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL 360
Query: 361 VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK 420
VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK
Sbjct: 361 VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK 420
Query: 421 GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKS 480
GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKS
Sbjct: 421 GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKS 480
Query: 481 KKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLN 540
KKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLN
Sbjct: 481 KKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLN 540
Query: 541 DNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV 600
DNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV
Sbjct: 541 DNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV 600
Query: 601 FRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINL 660
FRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINL
Sbjct: 601 FRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINL 660
Query: 661 LSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQ 720
LSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQ
Sbjct: 661 LSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQ 720
Query: 721 LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLI 780
LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLI
Sbjct: 721 LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLI 780
Query: 781 DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840
DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE
Sbjct: 781 DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840
Query: 841 GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT
Sbjct: 841 GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Query: 901 HRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCI 960
HRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCI
Sbjct: 901 HRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCI 960
Query: 961 QNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVC 1020
QNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVC
Sbjct: 961 QNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVC 1020
Query: 1021 ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVA 1080
ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVA
Sbjct: 1021 ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVA 1080
Query: 1081 HKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQE 1140
HKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQE
Sbjct: 1081 HKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQE 1140
Query: 1141 PTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGD 1200
PTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGD
Sbjct: 1141 PTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGD 1200
Query: 1201 NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPK 1260
NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPK
Sbjct: 1201 NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPK 1260
Query: 1261 SLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKA 1320
SLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKA
Sbjct: 1261 SLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKA 1320
Query: 1321 LPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG 1380
LPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG
Sbjct: 1321 LPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG 1380
Query: 1381 KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG 1440
KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG
Sbjct: 1381 KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG 1440
Query: 1441 EHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQ 1500
EHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQ
Sbjct: 1441 EHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQ 1500
Query: 1501 CTDGSSFVEEVERHLECGCLACS 1523
CTDGSSFVEEVERHLECGCLACS
Sbjct: 1501 CTDGSSFVEEVERHLECGCLACS 1523
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 2197 bits (5692), Expect = 0.0
Identities = 1016/1521 (66%), Positives = 1229/1521 (80%), Gaps = 18/1521 (1%)
Query: 16 LALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75
L+L L LA +L+ ACP +C+CS ++VDCHGL LR+VPR IPRN ERLDL+ NNITR
Sbjct: 11 LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITR 69
Query: 76 ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKL 135
ITK DFAGL++LRVL L +N++S IERGAFQDLK+LERLRLN+N LQ+ PELLF T KL
Sbjct: 70 ITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKL 129
Query: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
RLDLSENQIQ IPRKAFRG D+KNLQLD N ISCIEDGAFRALRDLE+LTLNNNNI+R
Sbjct: 130 YRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITR 189
Query: 196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
+ V SFNHMPK+RT RLHSN+LYCDCHLAWLSDWLRQR VG +T CM P HLRG NVA+
Sbjct: 190 LSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAE 249
Query: 256 VQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRL 314
VQK+E+VC S PSC+ + CP+ CTCSNNIVDCRGKGL EIP NLPE I EIRL
Sbjct: 250 VQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRL 307
Query: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
EQN+IK IP GAF+ YKKL+RID+S NQIS++APDAFQGL+SL SLVLYGNKITE+ K L
Sbjct: 308 EQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSL 367
Query: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHL 434
F+GL SLQLLLLNANKINCLRV+ FQDL NLNLLSLYDNKLQTI+KG F+PL++IQT+HL
Sbjct: 368 FEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHL 427
Query: 435 AQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCS-------- 486
AQNPF+CDCHLKWLADYL NPIETSGARC+SPRRLANKRI QIKSKKFRCS
Sbjct: 428 AQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIP 487
Query: 487 GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSV 546
G+EDYRS+ S +CF DL CPEKCRCEGT VDCSNQKL +IP H+P+Y +LRLN+NE +V
Sbjct: 488 GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTV 547
Query: 547 LEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSG 606
LEATGIFKKLP LRKIN SNNKI ++ EGAF+GA+ V E++LT N+LE V ++F+GL
Sbjct: 548 LEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLES 607
Query: 607 LKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 666
LKTLMLRSN I CV ND+F GLSSVRLLSLYDN+ITT+ PGAF TL SLST+NLL+NPFN
Sbjct: 608 LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667
Query: 667 CNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCD-GNEESSCQLSPRC 725
CNC+LAWLG+WLRK+RIV+GNPRCQKP+FLKEIPIQDVAIQDFTCD GN+++SC RC
Sbjct: 668 CNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 727
Query: 726 PEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNN 785
P +CTC++TVVRCSNKGL+ LP+G+P+DVTELYL+GN T VP+ELS +HLTLIDLSNN
Sbjct: 728 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 787
Query: 786 SISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFND 845
IS L+N +FSNM+ L TLILSYNRLRCIP F+GL+SLR+L+LHGNDIS VPEG+FND
Sbjct: 788 RISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFND 847
Query: 846 LTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC 905
L++LSHLA+G NPL+CDC+++WLS+WVK+ YKEPGIARC+ P MAD+LLLTTP+ +F C
Sbjct: 848 LSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC 907
Query: 906 KGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQ 965
+GPVD+NI+AKCN CLS+PCKN+GTC DPV+ YRC CPY +KG+DC VPI+ CI NPC+
Sbjct: 908 QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCK 967
Query: 966 HGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPN 1025
HGGTCHL + +DGF C C GFEG+ CE+N DDCEDNDCENN+TCVDGINNY C+CPP
Sbjct: 968 HGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPE 1027
Query: 1026 YTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRH 1085
YTGELC+E +D C +LN CQH++KCI KGF C+C PGY G+ C+ D DDC +KC++
Sbjct: 1028 YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKN 1087
Query: 1086 GAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRC 1145
GA C D +NGYTC CP+G+SG FCE PPMVL +TSPCD ++CQNGAQCIV EP C+C
Sbjct: 1088 GAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQC 1147
Query: 1146 PPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLA 1205
PG+ G +CEKL++VNF+ K+SY+++ SAKVRPQ NI+LQ+ATD+D+GILLYKGD D +A
Sbjct: 1148 LPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIA 1207
Query: 1206 LELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1265
+ELY+G VR YD+ S P + +YSVET+NDG FH VEL+ L+Q+L+L VD G PK + L
Sbjct: 1208 VELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNL 1267
Query: 1266 QKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQS 1325
KQ + +SPLY+GG+P + +++LRQ + FHGCI + IN+ELQDF+ +P Q+
Sbjct: 1268 SKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQT 1327
Query: 1326 LGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCV 1383
G+ PGC+ C VC HG C+ + CEC+ GW GPLCDQ DPCLG++C HG C+
Sbjct: 1328 -GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
Query: 1384 ATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEH 1442
SY CKC EG+GG LCD + D N C A KC HG+C +S G+PYC C G++G+
Sbjct: 1387 PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
Query: 1443 CQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQCCQPTRSKRRKYVFQC 1501
C +E C G+ +R+ ++Q+GYA+C T KV +ECRGGC G QCC P RSKRRKY F+C
Sbjct: 1447 CDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFEC 1506
Query: 1502 TDGSSFVEEVERHLECGCLAC 1522
TDGSSFV+EVE+ ++CGC C
Sbjct: 1507 TDGSSFVDEVEKVVKCGCTRC 1527
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 1949 bits (5050), Expect = 0.0
Identities = 913/1538 (59%), Positives = 1141/1538 (74%), Gaps = 21/1538 (1%)
Query: 1 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 60
+ PGW VR L L L A+ G A ACP CTC+ +VDCHG GL+A+P+ IP
Sbjct: 3 LTPGWGSSAGPVRPELWLLLWAAAWRLG--ASACPALCTCTGTTVDCHGTGLQAIPKNIP 60
Query: 61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120
RN ERL+L+ NNITRI K DFAGLK LRVL L +NQ+ +ERGAF D+K+LERLRLN+N+
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
L +LPELLFQ+ L+RLDLSEN IQ IPRKAFRG TD+KNLQLD N ISCIE+GAFRAL
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240
R LE+LTLNNNNI+ I V+SFNHMPK+RT RLHSNHL+CDCHLAWLS WLRQR T+G FT
Sbjct: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 240
Query: 241 LCMAPVHLRGFNVADVQKKEYVCPAPHS--EPPSCNANSISCPSPCTCSNNIVDCRGKGL 298
C P LRG NVA+VQK E+ C P+C +S SCP+ CTCSN IVDCRGKGL
Sbjct: 241 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 300
Query: 299 MEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLT 358
IPANLPE + EIRLE N IK+IP GAF+ Y+KL+RID+S NQI++IAPDAFQGL+SL
Sbjct: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
Query: 359 SLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI 418
SLVLYGNKIT++ +G+F GL +LQLLLLNANKINC+R + FQDLQNL+LLSLYDNK+Q++
Sbjct: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
Query: 419 SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQI 478
+KG F L++IQTLHLAQNPF+CDC+LKWLAD+L+ NPIETSGARC+SPRRLANKRI QI
Sbjct: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
Query: 479 KSKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHL 530
KSKKFRCS G+EDY+ +SEC D+VCP KCRCE +V+CS+ KL +IP +
Sbjct: 481 KSKKFRCSAKEQYFIPGTEDYQ--LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI 538
Query: 531 PEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTG 590
P+ +LRLN+NE+S+LEATG+FKKL +L+KINLSNNK+ E+ +GAF+GAASV EL LT
Sbjct: 539 PQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTA 598
Query: 591 NQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT 650
NQLE++ +FRGL GL+TLMLR+N I C+ ND+F GL +VRLLSLYDN+ITT++PGAF
Sbjct: 599 NQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFD 658
Query: 651 TLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFT 710
TL SLST+NLL+NPFNCNC LAWLG WLRKR+IV+GNPRCQ P FL++IP+QDVA DF
Sbjct: 659 TLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 718
Query: 711 CD-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR 769
C+ G EE C P+CP++C C++TVVRCSNK LRALP+G+PK+VTELYL+GN T VP
Sbjct: 719 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG 778
Query: 770 ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLT 829
+LS ++L L+DLSNN IS L+N +F+NMS L+TLILSYN L+CIP AF GLRSLR+L+
Sbjct: 779 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLS 838
Query: 830 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEP 889
LHGNDIS++ EG F D+TSLSHLA+G NPL+CDC LRWLS WVK GYKEPGIARC+ P+
Sbjct: 839 LHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQD 898
Query: 890 MADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKG 949
M +LLLTTP +F+C+GP + + AKC+ CLSSPC+N GTC DP+E+YRCACP YKG
Sbjct: 899 MEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKG 958
Query: 950 KDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNA 1009
+DC V +++C PC++GGTCH + F+CSCP GFEG C +N DDC D+ C N
Sbjct: 959 RDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGG 1018
Query: 1010 TCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGK 1069
CVDG+ NY C CP Y G+ C++++D C P+LN CQHEA+C+ G CEC+PGY+G
Sbjct: 1019 VCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGD 1078
Query: 1070 LCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQ 1129
C + DDC H+C++GAQC+D +N Y+C C +G+SG CE PP + SPC+ ECQ
Sbjct: 1079 NCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP-APKSPCEGTECQ 1137
Query: 1130 NGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATD 1189
NGA C+ P C+C PGF GP CEKL++VNFV +D+Y++ + P+ANI+LQV+T
Sbjct: 1138 NGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTA 1197
Query: 1190 KDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQT 1249
+DNGILLY GDND +A+ELYQGHVR+ YD S P + +YS ET+NDGQFH+VELV +Q
Sbjct: 1198 EDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQM 1257
Query: 1250 LNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEV 1309
+NL +D G+P ++ K + +PLY+GG+P +A R GFHGCI +
Sbjct: 1258 VNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNL 1317
Query: 1310 RINNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQE 1367
INNELQDF + GV PGC+ C C HG+C+ +C C GW G CDQ
Sbjct: 1318 YINNELQDFTKTQMKP-GVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP 1376
Query: 1368 ARDPCLGHRCHHGKCV-ATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISD 1426
A PC GH+C HG+CV SY C+C +GY G LC+ A C +C HG C S
Sbjct: 1377 ADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASG 1436
Query: 1427 QGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQ 1485
+C+C PGFSGE C+QE+ C G VR+ + Q+GYA C T + +ECRG C G
Sbjct: 1437 TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQG 1496
Query: 1486 CCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS 1523
CCQ R KRRK+ F+C+DG+SF EEVE+ +CGC C+
Sbjct: 1497 CCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA 1534
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 214 bits (545), Expect = 5e-55
Identities = 152/539 (28%), Positives = 237/539 (43%), Gaps = 67/539 (12%)
Query: 881 IARCSSPEPMADRLLLTTPTHRFQCKGPVD---INIVAKCNACLSSPCKNNGTCTQDPVE 937
+ C+S +P + R+ C P + +N + + C S PC N TC QD +
Sbjct: 187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATC-QDALG 244
Query: 938 LYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCP-LGFEGQRCEIN 996
Y C C + G C + + C PC HGG C ++ +SC+C GF G CE
Sbjct: 245 AYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENR---YSCNCTGSGFTGTHCETL 301
Query: 997 PDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLD- 1055
C C NNATC D ++NY C C P YTG C+ ++ C N CQ +C+ L
Sbjct: 302 MPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNEC--NSNPCQSNGECVELSS 359
Query: 1056 -------------------KGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
G+ C C PG++G CE D ++C ++ C++G C + Y
Sbjct: 360 EKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNY 419
Query: 1097 TCTCP------QGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEP----TCRCP 1146
TC CP + G C +LL C +C N CI Q+ +C CP
Sbjct: 420 TCHCPFDNLSRTFYGGRDCSD----ILL---GCTHQQCLNNGTCIPHFQDGQHGFSCLCP 472
Query: 1147 PGFAGPRCEKLITVNFVGKDSYVELASAKVRPQ---ANISLQVATDKDNGILLYKGDNDP 1203
G+ G CE T++F G D ++ + S V + NI+L+ T + +LL++ + D
Sbjct: 473 SGYTGSLCEIATTLSFEG-DGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDV 531
Query: 1204 -LALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQ-TLNLVVDKGTPKS 1261
+ LEL G++ L + ++ +DG++H VE++ TL L+ D K
Sbjct: 532 FVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKC 591
Query: 1262 LGK----LQKQPAVGINSPLYLGGIP---TSTGLSALRQGTDRPLGGFHGCIHEVRIN-N 1313
+ K L+ ++ +LGG+P TS G++ L F GC+ +++I+ N
Sbjct: 592 IAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWN 651
Query: 1314 ELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKD-----SVVCECRPGWTGPLCDQE 1367
+ SL V GC C+ C+S + S C+C + GP C +E
Sbjct: 652 HITLENISSGSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLRE 710
Score = 192 bits (489), Expect = 2e-48
Identities = 117/364 (32%), Positives = 170/364 (46%), Gaps = 36/364 (9%)
Query: 797 NMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGT 856
N+++L LS++ L I ++F + R L+ + S+ + S ++ S S A
Sbjct: 5 NINYLLIFYLSFSLLIYIK-NSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTA--- 60
Query: 857 NPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHR-FQCKGPVDIN--- 912
N L DC K+P C S + TP R F CK P +
Sbjct: 61 NNLDKDCD----------NMKDP----CFSNPCQGSATCVNTPGERSFLCKCPPGYSGTI 106
Query: 913 IVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHL 972
+C + C++ G C QDP+ C CP Y G+ C + + C +PCQ+G C
Sbjct: 107 CETTIGSCGKNSCQHGGICHQDPIYPV-CICPAGYAGRFCEIDHDECASSPCQNGAVCQ- 164
Query: 973 SDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD 1032
DG+SC C G++G+ C++ D+C + C+N ATC++ I Y CICP NY+G C+
Sbjct: 165 --DGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Query: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDT 1092
ID C + C + A C + C+C PG+ G CE + D+C + C HG CVD
Sbjct: 223 LEIDECWSQ--PCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDG 280
Query: 1093 INGYTCTCP-QGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
N Y+C C GF+G CE P+ C C N A C TC C PG+ G
Sbjct: 281 ENRYSCNCTGSGFTGTHCETLMPL-------CWSKPCHNNATCEDSVDNYTCHCWPGYTG 333
Query: 1152 PRCE 1155
+CE
Sbjct: 334 AQCE 337
Score = 152 bits (383), Expect = 3e-36
Identities = 71/207 (34%), Positives = 105/207 (50%), Gaps = 13/207 (6%)
Query: 912 NIVAKC---NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGG 968
++V C N C S+PC + G C +D Y C+CP + GK C + I+ C NPC HG
Sbjct: 1132 SVVTGCLQLNVCNSNPCLHGGNC-EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN 1190
Query: 969 TCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTG 1028
+ C+C G+ G CE++ D+C+ + C N ATC+ N Y C+C N+TG
Sbjct: 1191 C----SDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTG 1246
Query: 1029 ELCDEV-IDHCV---PELNL-CQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKC 1083
+ C + + V + NL C + C C C PG++G+ CE D D+C + C
Sbjct: 1247 KFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPC 1306
Query: 1084 RHGAQCVDTINGYTCTCPQGFSGPFCE 1110
+G C D +N + C C F+G CE
Sbjct: 1307 VNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Score = 122 bits (305), Expect = 3e-27
Identities = 58/157 (36%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 1000 CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFS 1059
C N C + C D ++Y C CP ++G+ C+ ID C N C H C +
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFS--NPCIH-GNCSDRVAAYH 1199
Query: 1060 CECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQ 1119
C C PGY+G CE D D+C +H+C +GA C+ NGY+C C F+G FC +
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVC 1259
Query: 1120 TSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
+ C NG C Q E C C PGF G CEK
Sbjct: 1260 GNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEK 1296
Score = 107 bits (267), Expect = 9e-23
Identities = 105/406 (25%), Positives = 159/406 (39%), Gaps = 70/406 (17%)
Query: 1071 CETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQN 1130
C DN C ++ C +G C + ++C+CP SG CE + C C +
Sbjct: 885 CAGDNS-CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE--------EVQWCGFSPCPH 935
Query: 1131 GAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDK 1190
GAQC V Q C F G + L N R NI+ T +
Sbjct: 936 GAQCQPVLQGFECIANAVFNGQSGQILFRSN-----------GNITRELTNITFGFRT-R 983
Query: 1191 DNGILLYKGDNDPLALELYQGHVRLVYDSLSSPP---TTVYSVETVNDGQFHSVELVTLN 1247
D +++ + +P L + RL + S ++ S+++VNDG +H V TL+
Sbjct: 984 DANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEV---TLS 1040
Query: 1248 QTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLG------- 1300
T D + S +++ V +P I T + L+ L+ TD +G
Sbjct: 1041 MT-----DPLSQTSRWQME----VDNETPFVTSTIATGS-LNFLKDNTDIYVGDRAIDNI 1090
Query: 1301 -GFHGCIHEVRIN--------------NELQDFKALPPQSLGVSPGCKSCTVCKH----- 1340
G GC+ + I N+ Q+ + L + V GC VC
Sbjct: 1091 KGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLH 1150
Query: 1341 -GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGG 1399
G C + S C C GW+G C+ D C + C HG C +Y C C GY G
Sbjct: 1151 GGNCEDIYS-SYHCSCPLGWSGKHCELNI-DECFSNPCIHGNCSDRVAAYHCTCEPGYTG 1208
Query: 1400 DLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
C+ D+ C + +C +G IS CLC F+G+ C+Q
Sbjct: 1209 VNCEVDIDN---CQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ 1251
Score = 77.4 bits (189), Expect = 1e-13
Identities = 50/181 (27%), Positives = 70/181 (38%), Gaps = 17/181 (9%)
Query: 860 HCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCK-GPVDINIVAKCN 918
HC C L W + + E I C S + + C+ G +N +
Sbjct: 1162 HCSCPLGWSGK-----HCELNIDECFSNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDID 1216
Query: 919 ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDC-------TVPINTCIQNPCQHGGTCH 971
C S C N TC Y C C ++ GK C TV N C +GG C
Sbjct: 1217 NCQSHQCANGATCISH-TNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNC- 1274
Query: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
+ C C GF G+ CE + D+C + C N C D +N + C+C + GE C
Sbjct: 1275 --TEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERC 1332
Query: 1032 D 1032
+
Sbjct: 1333 E 1333
Score = 71.2 bits (173), Expect = 7e-12
Identities = 81/357 (22%), Positives = 133/357 (37%), Gaps = 67/357 (18%)
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDS----YVELASAKVRP 1178
C+ CQ+ +CI + C C + GP C + G+D +
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESYGD 735
Query: 1179 QANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQF 1238
++S+ V T + +G+LL ++ + ++ RL + +SP V V +NDG
Sbjct: 736 TISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFV--LNDGNV 793
Query: 1239 H---------SVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLS 1289
H +EL +Q L + S K++K + Y+GG+P
Sbjct: 794 HLISLKIKPYKIELYQSSQNLGFI-----SASTWKIEKGDVI------YIGGLPD----- 837
Query: 1290 ALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKD 1349
+Q T+ G F GCI +VR+NN+ +F P + ++P
Sbjct: 838 --KQETELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNP------------------- 876
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
V+ G G + C + CH+ G C + + C C G C +
Sbjct: 877 -VLVNVTQGCAGD-------NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC----EE 924
Query: 1409 ANACSAFKCHHG-QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGY 1464
C C HG QC QG C+ F+G+ Q G + RE+ G+
Sbjct: 925 VQWCGFSPCPHGAQCQPVLQGFE-CIANAVFNGQSGQILFRSNGNITRELTNITFGF 980
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/129 (31%), Positives = 54/129 (41%), Gaps = 17/129 (13%)
Query: 1329 SPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGT 1387
S C++ VC+ G+ D C C PG+ G CD E D C C + C+
Sbjct: 154 SSPCQNGAVCQDGI------DGYSCFCVPGYQGRHCDLEV-DECASDPCKNEATCLNEIG 206
Query: 1388 SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ--- 1444
Y C C Y G C+ + D C + C +G G +C C PGF G+HC+
Sbjct: 207 RYTCICPHNYSGVNCELEIDE---CWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNT 263
Query: 1445 ---QENPCL 1450
PCL
Sbjct: 264 DECASQPCL 272
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 12/119 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEA---RDPCLGHRCH-HGKCVATG- 1386
C S + + C+ KD+ +C T D++ +DPC + C CV T
Sbjct: 34 CLSNSCQNNSTCKDFSKDN---DCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPG 90
Query: 1387 -TSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
S++CKC GY G +C+ + +C C HG D P C+C G++G C+
Sbjct: 91 ERSFLCKCPPGYSGTICET---TIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Score = 59.3 bits (142), Expect = 3e-08
Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 7/99 (7%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSY-MCKCAEGYGGDLCDNKNDS 1408
S +C+C PG++G +C+ C + C HG Y +C C GY G C+ +D
Sbjct: 93 SFLCKCPPGYSGTICETTIGS-CGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDE 151
Query: 1409 ANACSAFKCHHGQ-CHISDQGEPYCLCQPGFSGEHCQQE 1446
C++ C +G C G C C PG+ G HC E
Sbjct: 152 ---CASSPCQNGAVCQDGIDGYS-CFCVPGYQGRHCDLE 186
Score = 58.2 bits (139), Expect = 6e-08
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 4/75 (5%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSC 984
C N G CT+ EL +C C + G+ C I+ C +PC +GG C + F C C
Sbjct: 1268 CYNGGNCTEFQTEL-KCMCRPGFTGEWCEKDIDECASDPCVNGGLCQ---DLLNKFQCLC 1323
Query: 985 PLGFEGQRCEINPDD 999
+ F G+RCE++ D
Sbjct: 1324 DVAFAGERCEVDLAD 1338
Score = 55.1 bits (131), Expect = 5e-07
Identities = 27/73 (36%), Positives = 36/73 (49%), Gaps = 4/73 (5%)
Query: 957 NTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
N+C NPC +GG CH S D FSCSCP G+ CE C + C + A C +
Sbjct: 889 NSCKSNPCHNGGVCH---SRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQ 944
Query: 1017 NYVCICPPNYTGE 1029
+ CI + G+
Sbjct: 945 GFECIANAVFNGQ 957
Score = 53.1 bits (126), Expect = 2e-06
Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 908 PVDINIVAKC---NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPC 964
PV +N+ C N+C S+PC N G C + + C+CP GK C + C +PC
Sbjct: 876 PVLVNVTQGCAGDNSCKSNPCHNGGVC-HSRWDDFSCSCPALTSGKACE-EVQWCGFSPC 933
Query: 965 QHGGTCHLSDSHKDGFSCSCPLGFEGQRCEI 995
HG C GF C F GQ +I
Sbjct: 934 PHGAQC---QPVLQGFECIANAVFNGQSGQI 961
Score = 52.8 bits (125), Expect = 3e-06
Identities = 35/123 (28%), Positives = 47/123 (38%), Gaps = 18/123 (14%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLC----DQEARDPCLGHRCHHGKCVATGTSYMCKC 1393
C +G + C+C PG+ G C D+ A PCL H G CV Y C C
Sbjct: 233 CLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCL----HGGLCVDGENRYSCNC 288
Query: 1394 -AEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QE 1446
G+ G C+ C + CH+ C C PG++G C+
Sbjct: 289 TGSGFTGTHCET---LMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNS 345
Query: 1447 NPC 1449
NPC
Sbjct: 346 NPC 348
Score = 52.0 bits (123), Expect = 4e-06
Identities = 41/141 (29%), Positives = 58/141 (41%), Gaps = 34/141 (24%)
Query: 1338 CKHG-LCRSVEKDSVVCECR-PGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCA 1394
C HG LC E + C C G+TG C+ C CH+ C + +Y C C
Sbjct: 271 CLHGGLCVDGE-NRYSCNCTGSGFTGTHCET-LMPLCWSKPCHNNATCEDSVDNYTCHCW 328
Query: 1395 EGYGGDLCDNKNDSANACSAFKCH-HGQCHISDQGEPY-------------------CLC 1434
GY G C+ N C++ C +G+C + Y C+C
Sbjct: 329 PGYTGAQCEI---DLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCIC 385
Query: 1435 QPGFSGEHCQQE------NPC 1449
QPGF+G HC+++ NPC
Sbjct: 386 QPGFTGIHCEEDVNECSSNPC 406
Score = 51.6 bits (122), Expect = 6e-06
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 13/101 (12%)
Query: 1071 CETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSG--PFCEHPPPMVLLQTSPCDQYEC 1128
C +N C+++ C++ + C D C+C + C++ PC C
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDN-------MKDPCFSNPC 79
Query: 1129 QNGAQCIVVQQEPT--CRCPPGFAGPRCEKLITVNFVGKDS 1167
Q A C+ E + C+CPPG++G CE T+ GK+S
Sbjct: 80 QGSATCVNTPGERSFLCKCPPGYSGTICE--TTIGSCGKNS 118
Score = 49.3 bits (116), Expect = 3e-05
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 15/109 (13%)
Query: 1347 EKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKC------AEGYGG 1399
E VC C+PG+TG C+++ + C + C + G C +Y C C YGG
Sbjct: 377 EASGYVCICQPGFTGIHCEEDVNE-CSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGG 435
Query: 1400 DLCDNKNDSANACSAFKC-HHGQC--HISDQGEPY-CLCQPGFSGEHCQ 1444
C +D C+ +C ++G C H D + CLC G++G C+
Sbjct: 436 RDC---SDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Query: 998 DDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKG 1057
+ C+ N C N C +++ C CP +G+ C+EV C + C H A+C P+ +G
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEV-QWC--GFSPCPHGAQCQPVLQG 945
Query: 1058 FSCECVPGYSGK 1069
F C ++G+
Sbjct: 946 FECIANAVFNGQ 957
Score = 40.0 bits (92), Expect = 0.017
Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 1333 KSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQE----ARDPCLGHRCHHGKCVATGTS 1388
K+ C +G + + + C CRPG+TG C+++ A DPC+ + G C
Sbjct: 1263 KTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCV----NGGLCQDLLNK 1318
Query: 1389 YMCKCAEGYGGDLCD 1403
+ C C + G+ C+
Sbjct: 1319 FQCLCDVAFAGERCE 1333
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 214 bits (544), Expect = 7e-55
Identities = 169/613 (27%), Positives = 234/613 (38%), Gaps = 125/613 (20%)
Query: 889 PMADRLLLTTPTHRFQCK---GPVDINIVAKCNAC-LSSPCKNNGTCTQDPVELYRCACP 944
P A+ TT ++F CK G N C + C++ GTC P Y+C CP
Sbjct: 152 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS-YQCQCP 210
Query: 945 YSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDND 1004
+ G+ C C +PC +GGTC + F C+C GFEG CE N DDC ++
Sbjct: 211 QGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT--FECNCLPGFEGSTCERNIDDCPNHR 268
Query: 1005 CENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVP 1064
C+N CVDG+N Y C CPP +TG+ C E +D C+ + N CQ+ C + G+ C CV
Sbjct: 269 CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVN 328
Query: 1065 GYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCD 1124
G+SG C + DDC C G+ C+D + ++C CP+G +G C C
Sbjct: 329 GWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCH--------LDDACI 380
Query: 1125 QYECQNGAQCIV--VQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANI 1182
C GA C + + C CP G+ G C + + E A A P +
Sbjct: 381 SNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVD----------ECAMANSNPCEHA 430
Query: 1183 SLQVATDKDNGILLYKG------------------DNDPLALELYQG------------H 1212
V TD KG ND L+ G H
Sbjct: 431 GKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Query: 1213 VRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVG 1272
L + S P VN+GQ VDK + + Q G
Sbjct: 491 CELEINECQSNP-------CVNNGQ---------------CVDK-----VNRFQCLCPPG 523
Query: 1273 INSPLYLGGIPTSTGLSALR--QGTDRPLG-------GFHGCIHEVRINNELQDFKALPP 1323
P+ I + L + D P G GF G + E I+N D P
Sbjct: 524 FTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPD----PC 579
Query: 1324 QSLGVSPGCKSCT-VCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKC 1382
G S T +C G ++ D + D+ PCL + G+C
Sbjct: 580 HHGQCQDGIDSYTCICNPGYMGAICSDQI-------------DECYSSPCL----NDGRC 622
Query: 1383 VATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEH 1442
+ Y C C G G C+ D C++ C HG C + C+C PGF+G+
Sbjct: 623 IDLVNGYQCNCQPGTSGVNCEINFDD---CASNPCIHGIC-MDGINRYSCVCSPGFTGQR 678
Query: 1443 CQ------QENPC 1449
C NPC
Sbjct: 679 CNIDIDECASNPC 691
Score = 198 bits (503), Expect = 4e-50
Identities = 98/267 (36%), Positives = 135/267 (50%), Gaps = 27/267 (10%)
Query: 903 FQCKGPVDIN---IVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC 959
F C PV + + N C S PC N GTC D + YRC+CP Y GK+C +N C
Sbjct: 1009 FSCLCPVGFTGSFCLHEINECSSHPCLNEGTCV-DGLGTYRCSCPLGYTGKNCQTLVNLC 1067
Query: 960 IQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCE----------DNDCENNA 1009
++PC++ GTC + C CP G+ G C++ C+ ++ C+++
Sbjct: 1068 SRSPCKNKGTCVQKKAESQ---CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSG 1124
Query: 1010 TCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGK 1069
C++ N + C CP YTG C+E +D C N CQH A C G+ CECVPGY G
Sbjct: 1125 VCINAGNTHYCQCPLGYTGSYCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGV 1182
Query: 1070 LCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQ-YEC 1128
CE + D+C C++G C+D +N + C+CP G G CE C + C
Sbjct: 1183 NCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEE-------NIDDCARGPHC 1235
Query: 1129 QNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
NG QC+ +CRC PGFAG RCE
Sbjct: 1236 LNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Score = 196 bits (498), Expect = 1e-49
Identities = 92/255 (36%), Positives = 134/255 (52%), Gaps = 12/255 (4%)
Query: 901 HRFQCK-GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC 959
+R CK G N + C S+PC N GTC D + Y C C Y GK+C + C
Sbjct: 779 YRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDD-ISGYTCHCVLPYTGKNCQTVLAPC 837
Query: 960 IQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYV 1019
NPC++ C S + + ++C C G++GQRC I+ D+C C N+ C + +Y+
Sbjct: 838 SPNPCENAAVCKESPNF-ESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYM 896
Query: 1020 CICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCV 1079
C CPP ++G C+E ID C+ N CQ+ C+ FSC C+PG++G C+TD ++C+
Sbjct: 897 CECPPGFSGMDCEEDIDDCLA--NPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECL 954
Query: 1080 AHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQ 1139
+ C++G C D +N YTC C GF G CE+ + C + C NG C+
Sbjct: 955 SEPCKNGGTCSDYVNSYTCKCQAGFDGVHCEN-------NINECTESSCFNGGTCVDGIN 1007
Query: 1140 EPTCRCPPGFAGPRC 1154
+C CP GF G C
Sbjct: 1008 SFSCLCPVGFTGSFC 1022
Score = 196 bits (498), Expect = 1e-49
Identities = 83/242 (34%), Positives = 128/242 (52%), Gaps = 13/242 (5%)
Query: 920 CLSSPCKNNGTCTQDP-VELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKD 978
C +PC+N C + P E Y C C ++G+ CT+ I+ CI PC + G CH + +
Sbjct: 837 CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCH---NTQG 893
Query: 979 GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHC 1038
+ C CP GF G CE + DDC N C+N +C+DG+N + C+C P +TG+ C ++ C
Sbjct: 894 SYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNEC 953
Query: 1039 VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
+ E C++ C ++C+C G+ G CE + ++C C +G CVD IN ++C
Sbjct: 954 LSEP--CKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC 1011
Query: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
CP GF+G FC H + + C + C N C+ C CP G+ G C+ L+
Sbjct: 1012 LCPVGFTGSFCLH-------EINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLV 1064
Query: 1159 TV 1160
+
Sbjct: 1065 NL 1066
Score = 196 bits (497), Expect = 2e-49
Identities = 101/305 (33%), Positives = 146/305 (47%), Gaps = 27/305 (8%)
Query: 861 CDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCN-- 918
C C W + + A C+ DR+ F C P + C+
Sbjct: 324 CVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVA------SFSCMCP-EGKAGLLCHLD 376
Query: 919 -ACLSSPCKNNGTCTQDPVE-LYRCACPYSYKGKDCTVPINTCIQ---NPCQHGGTCHLS 973
AC+S+PC C +P+ Y C CP YKG DCT ++ C NPC+H G C +
Sbjct: 377 DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNT 436
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDE 1033
D F C C G+ G RCE++ ++C + C+N+ATC+D I + C+C P + G C+
Sbjct: 437 DG---AFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCEL 493
Query: 1034 VIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTI 1093
I+ C + N C + +C+ F C C PG++G +C+ D DDC + C +GA+C+D
Sbjct: 494 EINEC--QSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHP 551
Query: 1094 NGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
NGY C C GF+G CE + PC +CQ+G TC C PG+ G
Sbjct: 552 NGYECQCATGFTGVLCEEN--IDNCDPDPCHHGQCQDGIDSY------TCICNPGYMGAI 603
Query: 1154 CEKLI 1158
C I
Sbjct: 604 CSDQI 608
Score = 196 bits (497), Expect = 2e-49
Identities = 106/306 (34%), Positives = 150/306 (49%), Gaps = 25/306 (8%)
Query: 855 GTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDI 911
G N C CS + + E C+S P + F+C +GP
Sbjct: 662 GINRYSCVCSPGFTGQRCNIDIDE-----CAS-NPCRKGATCINGVNGFRCICPEGPHHP 715
Query: 912 NIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH 971
+ ++ N CLS+PC + G CT + Y+C C + G +C V N C+ NPCQ+GGTC
Sbjct: 716 SCYSQVNECLSNPCIH-GNCTGG-LSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTC- 772
Query: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
D+ +G+ C+C GF+G C++N D+C N C N TC D I+ Y C C YTG+ C
Sbjct: 773 --DNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNC 830
Query: 1032 DEVIDHCVPELNLCQHEAKC--IPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQC 1089
V+ C P N C++ A C P + ++C C PG+ G+ C D D+C++ C + C
Sbjct: 831 QTVLAPCSP--NPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLC 888
Query: 1090 VDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGF 1149
+T Y C CP GFSG CE C CQNG C+ +C C PGF
Sbjct: 889 HNTQGSYMCECPPGFSGMDCEE-------DIDDCLANPCQNGGSCMDGVNTFSCLCLPGF 941
Query: 1150 AGPRCE 1155
G +C+
Sbjct: 942 TGDKCQ 947
Score = 194 bits (492), Expect = 7e-49
Identities = 96/254 (37%), Positives = 131/254 (51%), Gaps = 15/254 (5%)
Query: 907 GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQH 966
G V IN N CLS+PC+N GTC + V YRC C +KG +C V I+ C NPC +
Sbjct: 748 GWVGINCEVDKNECLSNPCQNGGTC-DNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLN 806
Query: 967 GGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN--NYVCICPP 1024
GTC S G++C C L + G+ C+ C N CEN A C + N +Y C+C P
Sbjct: 807 QGTCFDDIS---GYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAP 863
Query: 1025 NYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCR 1084
+ G+ C ID C+ + C + C + CEC PG+SG CE D DDC+A+ C+
Sbjct: 864 GWQGQRCTIDIDECISKP--CMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQ 921
Query: 1085 HGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCR 1144
+G C+D +N ++C C GF+G C+ + C C+NG C TC+
Sbjct: 922 NGGSCMDGVNTFSCLCLPGFTGDKCQ-------TDMNECLSEPCKNGGTCSDYVNSYTCK 974
Query: 1145 CPPGFAGPRCEKLI 1158
C GF G CE I
Sbjct: 975 CQAGFDGVHCENNI 988
Score = 186 bits (471), Expect = 2e-46
Identities = 116/342 (33%), Positives = 152/342 (44%), Gaps = 34/342 (9%)
Query: 833 NDISSVPEGS-FNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMA 891
N+I+ E S FN T + G N C C + + + E C +
Sbjct: 986 NNINECTESSCFNGGTCVD----GINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCV 1041
Query: 892 DRLLLTTPTHRFQCK-GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGK 950
D L T+R C G N N C SPCKN GTC Q E +C CP + G
Sbjct: 1042 DGL----GTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAES-QCLCPSGWAGA 1096
Query: 951 DCTVPINTC----------IQNPCQHGGTC-HLSDSHKDGFSCSCPLGFEGQRCEINPDD 999
C VP +C +++ CQH G C + ++H C CPLG+ G CE D+
Sbjct: 1097 YCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY----CQCPLGYTGSYCEEQLDE 1152
Query: 1000 CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFS 1059
C N C++ ATC D I Y C C P Y G C+ +D C + CQ+ CI L F
Sbjct: 1153 CASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDEC--QNQPCQNGGTCIDLVNHFK 1210
Query: 1060 CECVPGYSGKLCETDNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLL 1118
C C PG G LCE + DDC C +G QC+D I GY+C C GF+G CE L
Sbjct: 1211 CSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECL- 1269
Query: 1119 QTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITV 1160
++PC + CI + + C C F G CE + V
Sbjct: 1270 -SNPCSS---EGSLDCIQLTNDYLCVCRSAFTGRHCETFVDV 1307
Score = 177 bits (448), Expect = 9e-44
Identities = 80/240 (33%), Positives = 125/240 (52%), Gaps = 9/240 (3%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
CL++PC+N G+C D V + C C + G C +N C+ PC++GGTC + +
Sbjct: 915 CLANPCQNGGSC-MDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTC---SDYVNS 970
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
++C C GF+G CE N ++C ++ C N TCVDGIN++ C+CP +TG C I+ C
Sbjct: 971 YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINEC- 1029
Query: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCT 1099
+ C +E C+ + C C GY+GK C+T + C C++ CV C
Sbjct: 1030 -SSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL 1088
Query: 1100 CPQGFSGPFCEHPP---PMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
CP G++G +C+ P + + ++ CQ+ CI C+CP G+ G CE+
Sbjct: 1089 CPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEE 1148
Score = 173 bits (439), Expect = 1e-42
Identities = 85/240 (35%), Positives = 123/240 (51%), Gaps = 13/240 (5%)
Query: 921 LSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGF 980
+S PC N GTC + Y C C + GK+C + C+ +PC +G TC + + F
Sbjct: 111 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTC---TTVANQF 166
Query: 981 SCSCPLGFEGQRCEINPDDCE-DNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
SC C GF GQ+CE + ++C+ C++ TC++ +Y C CP +TG+ CD + C
Sbjct: 167 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCA 226
Query: 1040 PELNLCQHEAKCIPL-DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
P + C + C D F C C+PG+ G CE + DDC H+C++G CVD +N Y C
Sbjct: 227 P--SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNC 284
Query: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
CP ++G FC LLQ + CQNG C C C G++G C + I
Sbjct: 285 RCPPQWTGQFCTEDVDECLLQPN-----ACQNGGTCANRNGGYGCVCVNGWSGDDCSENI 339
Score = 168 bits (425), Expect = 4e-41
Identities = 93/254 (36%), Positives = 121/254 (47%), Gaps = 23/254 (9%)
Query: 900 THRFQCK-GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT 958
TH QC G + + C S+PC++ TC+ D + YRC C Y+G +C ++
Sbjct: 1132 THYCQCPLGYTGSYCEEQLDECASNPCQHGATCS-DFIGGYRCECVPGYQGVNCEYEVDE 1190
Query: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDND-CENNATCVDGINN 1017
C PCQ+GGTC +H F CSCP G G CE N DDC C N C+D I
Sbjct: 1191 CQNQPCQNGGTCIDLVNH---FKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGG 1247
Query: 1018 YVCICPPNYTGELCDEVIDHCVPELNLCQHEAK--CIPLDKGFSCECVPGYSGKLCETDN 1075
Y C C P + GE C+ I+ C+ N C E CI L + C C ++G+ CET
Sbjct: 1248 YSCRCLPGFAGERCEGDINECLS--NPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFV 1305
Query: 1076 DDCVAHKCRHGAQCVDTIN---GYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132
D C C +G C N G+ C CP GFSG C+ S C Q +C+ G
Sbjct: 1306 DVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ----------SSCGQVKCRKGE 1355
Query: 1133 QCIVVQQEPTCRCP 1146
QC+ P C CP
Sbjct: 1356 QCVHTASGPRCFCP 1369
Score = 159 bits (403), Expect = 1e-38
Identities = 84/248 (33%), Positives = 114/248 (45%), Gaps = 22/248 (8%)
Query: 916 KCNA----CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGG-TC 970
+CN C S+PC+ TC V +RC CP C +N C+ NPC HG T
Sbjct: 678 RCNIDIDECASNPCRKGATCING-VNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTG 736
Query: 971 HLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL 1030
LS G+ C C G+ G CE++ ++C N C+N TC + +N Y C C + G
Sbjct: 737 GLS-----GYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYN 791
Query: 1031 CDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCV 1090
C ID C N C ++ C G++C CV Y+GK C+T C + C + A C
Sbjct: 792 CQVNIDECAS--NPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCK 849
Query: 1091 DTIN--GYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148
++ N YTC C G+ G C + C C N C Q C CPPG
Sbjct: 850 ESPNFESYTCLCAPGWQGQRCT-------IDIDECISKPCMNHGLCHNTQGSYMCECPPG 902
Query: 1149 FAGPRCEK 1156
F+G CE+
Sbjct: 903 FSGMDCEE 910
Score = 157 bits (398), Expect = 6e-38
Identities = 94/336 (27%), Positives = 136/336 (40%), Gaps = 61/336 (18%)
Query: 860 HCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDINIVAK 916
HC+C + + E C + D++ F C G ++ +
Sbjct: 441 HCECLKGYAGPRCEMDINECHSDPCQNDATCLDKI------GGFTCLCMPGFKGVHCELE 494
Query: 917 CNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSH 976
N C S+PC NNG C D V ++C CP + G C + I+ C PC +G C H
Sbjct: 495 INECQSNPCVNNGQCV-DKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCI---DH 550
Query: 977 KDGFSCSCPLGFEGQRCEINPDDCEDNDCE------------------------------ 1006
+G+ C C GF G CE N D+C+ + C
Sbjct: 551 PNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDE 610
Query: 1007 -------NNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFS 1059
N+ C+D +N Y C C P +G C+ D C N C H C+ +S
Sbjct: 611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCAS--NPCIH-GICMDGINRYS 667
Query: 1060 CECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQ 1119
C C PG++G+ C D D+C ++ CR GA C++ +NG+ C CP+G P C L
Sbjct: 668 CVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECL-- 725
Query: 1120 TSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
++PC C G C C G+ G CE
Sbjct: 726 SNPCIHGNCTGGLSGY------KCLCDAGWVGINCE 755
Score = 117 bits (293), Expect = 8e-26
Identities = 65/199 (32%), Positives = 91/199 (45%), Gaps = 15/199 (7%)
Query: 963 PCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDG--INNYVC 1020
PC + G C H C CP GF G+ C+ + D CE N C+N TCV + C
Sbjct: 34 PCVNEGMC--VTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATC 90
Query: 1021 ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDDCV 1079
C +TGE C H C + C L + + C C G++GK C+ D C+
Sbjct: 91 RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACL 149
Query: 1080 AHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCD-QYECQNGAQCIVVQ 1138
+H C +G+ C N ++C C GF+G CE + CD CQ+G C+ +
Sbjct: 150 SHPCANGSTCTTVANQFSCKCLTGFTGQKCE-------TDVNECDIPGHCQHGGTCLNLP 202
Query: 1139 QEPTCRCPPGFAGPRCEKL 1157
C+CP GF G C+ L
Sbjct: 203 GSYQCQCPQGFTGQYCDSL 221
Score = 109 bits (273), Expect = 2e-23
Identities = 78/271 (28%), Positives = 111/271 (40%), Gaps = 48/271 (17%)
Query: 918 NACLSSPCKNNGTCTQDPVEL---YRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD 974
N CLS+PC + G+ D ++L Y C C ++ G+ C ++ C Q PC +GGTC ++
Sbjct: 1266 NECLSNPCSSEGSL--DCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVAS 1323
Query: 975 SHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICP-PNYTGELCDE 1033
+ DGF C CP GF G RC+ C C CV + C CP P C
Sbjct: 1324 NMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCAS 1380
Query: 1034 VIDHCVPELNLCQHEAKCIPLDKG--FSCECVPGYSGKLCE-------TDNDDCVAHKCR 1084
+ CQH C P + +SC+C P +SG CE T C++ C
Sbjct: 1381 ---------SPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCA 1431
Query: 1085 HGAQ---CVDTINGYTC-----TCPQGFSGPF--CEHPPPMVLLQTSPCDQYECQNGAQC 1134
A+ C + N + C C P+ C P P + CD E N +C
Sbjct: 1432 DKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCD--ELCNTVEC 1489
Query: 1135 IVVQQE-----PTCR----CPPGFAGPRCEK 1156
+ E TC+ C F C++
Sbjct: 1490 LFDNFECQGNSKTCKYDKYCADHFKDNHCDQ 1520
Score = 82.8 bits (203), Expect = 2e-15
Identities = 54/178 (30%), Positives = 77/178 (43%), Gaps = 24/178 (13%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C++ VCK S +S C C PGW G C + D C+ C +HG C T SYM
Sbjct: 842 CENAAVCKE----SPNFESYTCLCAPGWQGQRCTIDI-DECISKPCMNHGLCHNTQGSYM 896
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
C+C G+ G C+ D C A C +G + CLC PGF+G+ CQ + N C
Sbjct: 897 CECPPGFSGMDCEEDIDD---CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNEC 953
Query: 1450 LGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSF 1507
L + K +C+ +C+ G C+ + +CT+ S F
Sbjct: 954 LSEPC-------KNGGTCSDYVNSYTCKCQAGFDGVHCE-------NNINECTESSCF 997
Score = 78.6 bits (192), Expect = 4e-14
Identities = 47/128 (36%), Positives = 65/128 (50%), Gaps = 17/128 (13%)
Query: 1332 CKSCTVCKHGLCRSVEK-DSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSY 1389
C+S +G C V+K + C C PG+TGP+C + D C C +G KC+ Y
Sbjct: 498 CQSNPCVNNGQC--VDKVNRFQCLCPPGFTGPVCQIDI-DDCSSTPCLNGAKCIDHPNGY 554
Query: 1390 MCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQE-- 1446
C+CA G+ G LC+ D+ C CHHGQC D + Y C+C PG+ G C +
Sbjct: 555 ECQCATGFTGVLCEENIDN---CDPDPCHHGQC--QDGIDSYTCICNPGYMGAICSDQID 609
Query: 1447 ----NPCL 1450
+PCL
Sbjct: 610 ECYSSPCL 617
Score = 73.9 bits (180), Expect = 1e-12
Identities = 48/172 (27%), Positives = 71/172 (41%), Gaps = 14/172 (8%)
Query: 1320 ALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH 1379
A P +L G + C G+C + + C+C G+ G C RDPC +RC +
Sbjct: 20 AAPAHALQCRDGYEPCV--NEGMCVTYHNGTGYCKCPEGFLGEYCQH--RDPCEKNRCQN 75
Query: 1380 G-KCVATGT--SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQP 1436
G CVA C+CA G+ G+ C S + G CH+ + C CQ
Sbjct: 76 GGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQV 135
Query: 1437 GFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQ 1488
GF+G+ CQ + CL ++C T + +C G Q C+
Sbjct: 136 GFTGKECQWTDACLSHPC-------ANGSTCTTVANQFSCKCLTGFTGQKCE 180
Score = 72.4 bits (176), Expect = 3e-12
Identities = 41/121 (33%), Positives = 59/121 (48%), Gaps = 14/121 (11%)
Query: 1352 VCECRPGWTGPLCDQEARDPCLGHR--CHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
+C C G+ G C ++ + + + C H GKCV T ++ C+C +GY G C+
Sbjct: 400 ICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM---D 456
Query: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPCL--GQVVREVIRR 1460
N C + C + + G CLC PGF G HC+ Q NPC+ GQ V +V R
Sbjct: 457 INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516
Query: 1461 Q 1461
Q
Sbjct: 517 Q 517
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/160 (26%), Positives = 65/160 (40%), Gaps = 20/160 (12%)
Query: 1303 HGCIHEVRINNELQDFKALPPQSLGVSPGCKSCT-VCKHGLCRSV-----EKDSVVCECR 1356
H C++E + L ++ P C++ +C C++ +K C C
Sbjct: 1032 HPCLNEGTCVDGLGTYRCSCPLGY-TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCP 1090
Query: 1357 PGWTGPLCD---------QEARDPCLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKN 1406
GW G CD R + H C H G C+ G ++ C+C GY G C+ +
Sbjct: 1091 SGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQL 1150
Query: 1407 DSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
D C++ C HG G C C PG+ G +C+ E
Sbjct: 1151 DE---CASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYE 1187
Score = 65.9 bits (159), Expect = 3e-10
Identities = 46/166 (27%), Positives = 65/166 (39%), Gaps = 50/166 (30%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG----------- 1380
C S HGLC + + S +CEC PG++G C+++ D CL + C +G
Sbjct: 877 CISKPCMNHGLCHNTQ-GSYMCECPPGFSGMDCEEDI-DDCLANPCQNGGSCMDGVNTFS 934
Query: 1381 ----------------------KCVATGT------SYMCKCAEGYGGDLCDNKNDSANAC 1412
C GT SY CKC G+ G C+N + N C
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCEN---NINEC 991
Query: 1413 SAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE------NPCLGQ 1452
+ C +G + CLC GF+G C E +PCL +
Sbjct: 992 TESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNE 1037
Score = 63.5 bits (153), Expect = 1e-09
Identities = 42/134 (31%), Positives = 57/134 (42%), Gaps = 10/134 (7%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEG 1396
C+HG S CEC PG+ G C+ E D C C +G C+ + C C G
Sbjct: 1158 CQHGATCSDFIGGYRCECVPGYQGVNCEYEV-DECQNQPCQNGGTCIDLVNHFKCSCPPG 1216
Query: 1397 YGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE------NPCL 1450
G LC+ D A + GQC + G C C PGF+GE C+ + NPC
Sbjct: 1217 TRGLLCEENIDDC-ARGPHCLNGGQC-MDRIGGYSCRCLPGFAGERCEGDINECLSNPCS 1274
Query: 1451 GQVVREVIRRQKGY 1464
+ + I+ Y
Sbjct: 1275 SEGSLDCIQLTNDY 1288
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/183 (26%), Positives = 70/183 (38%), Gaps = 31/183 (16%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
C C PG G LC++ D G C + G+C+ Y C+C G+ G+ C+ N
Sbjct: 1211 CSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEG---DINE 1267
Query: 1412 CSAFKC-HHGQCHISDQGEPY-CLCQPGFSGEHCQ------QENPCLGQVVREVIRRQKG 1463
C + C G Y C+C+ F+G HC+ + PCL
Sbjct: 1268 CLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNG----------- 1316
Query: 1464 YASCATASKVP---IMECRGG-CGPQC---CQPTRSKRRKYVFQCTDGSSFVEEVERHLE 1516
+CA AS +P I C G G +C C + ++ + G R E
Sbjct: 1317 -GTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCE 1375
Query: 1517 CGC 1519
GC
Sbjct: 1376 SGC 1378
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/100 (33%), Positives = 44/100 (44%), Gaps = 5/100 (5%)
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKND 1407
+S C C G+TG C E + C H C + G CV +Y C C GY G C
Sbjct: 1007 NSFSCLCPVGFTGSFCLHEINE-CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTL-- 1063
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQEN 1447
N CS C + + + E CLC G++G +C N
Sbjct: 1064 -VNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPN 1102
Score = 57.0 bits (136), Expect = 1e-07
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 7/109 (6%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEG 1396
CK+G S +S C+C+ G+ G C+ + C C + G CV S+ C C G
Sbjct: 958 CKNGGTCSDYVNSYTCKCQAGFDGVHCENNINE-CTESSCFNGGTCVDGINSFSCLCPVG 1016
Query: 1397 YGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
+ G C ++ N CS+ C + G C + G C C G++G++CQ
Sbjct: 1017 FTGSFCLHE---INECSSHPCLNEGTC-VDGLGTYRCSCPLGYTGKNCQ 1061
Score = 56.6 bits (135), Expect = 2e-07
Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 7/118 (5%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGT-SYMCKCAE 1395
C+HG S C+C G+TG CD PC C + G C TG ++ C C
Sbjct: 192 CQHGGTCLNLPGSYQCQCPQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 250
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQ 1452
G+ G C+ D C +C +G + C C P ++G+ C ++ + CL Q
Sbjct: 251 GFEGSTCERNIDD---CPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQ 305
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 1337 VCKH-GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCA 1394
+C+H G+C + ++ C+C G+TG C+++ D C + C HG C Y C+C
Sbjct: 1119 LCQHSGVCINAG-NTHYCQCPLGYTGSYCEEQL-DECASNPCQHGATCSDFIGGYRCECV 1176
Query: 1395 EGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
GY G C+ + D C C +G I C C PG G C++
Sbjct: 1177 PGYQGVNCEYEVDE---CQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEE 1224
Score = 55.8 bits (133), Expect = 3e-07
Identities = 36/127 (28%), Positives = 51/127 (40%), Gaps = 16/127 (12%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
C+ C +G+ + C C G P C + + CL + C HG C + Y C
Sbjct: 691 CRKGATCINGV------NGFRCICPEGPHHPSCYSQVNE-CLSNPCIHGNCTGGLSGYKC 743
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------Q 1445
C G+ G C+ N C + C +G + C C+ GF G +CQ
Sbjct: 744 LCDAGWVGINCE---VDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECA 800
Query: 1446 ENPCLGQ 1452
NPCL Q
Sbjct: 801 SNPCLNQ 807
Score = 54.7 bits (130), Expect = 7e-07
Identities = 43/162 (26%), Positives = 60/162 (37%), Gaps = 30/162 (18%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEG 1396
C++G + C C GW+G C + D C C G C+ S+ C C EG
Sbjct: 309 CQNGGTCANRNGGYGCVCVNGWSGDDCSENI-DDCAFASCTPGSTCIDRVASFSCMCPEG 367
Query: 1397 YGGDLCDNKNDSANACSAFKCHHGQ-CHISD-QGEPYCLCQPGFSGEHCQQE-------- 1446
G LC +AC + CH G C + G+ C C G+ G C ++
Sbjct: 368 KAGLLC----HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMAN 423
Query: 1447 -NPCLGQVVREVIRRQKGYASCATASKVPIMEC-RGGCGPQC 1486
NPC + C EC +G GP+C
Sbjct: 424 SNPC------------EHAGKCVNTDGAFHCECLKGYAGPRC 453
Score = 53.9 bits (128), Expect = 1e-06
Identities = 31/99 (31%), Positives = 42/99 (42%), Gaps = 16/99 (16%)
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLCDNKND 1407
D +C C PG++G C C +C G+ CV T + C C + D
Sbjct: 1327 DGFICRCPPGFSGARCQSS----CGQVKCRKGEQCVHTASGPRC---------FCPSPRD 1373
Query: 1408 SANACSAFKCHH-GQCHISDQGEPY-CLCQPGFSGEHCQ 1444
+ C++ C H G CH Q Y C C P FSG C+
Sbjct: 1374 CESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE 1412
Score = 49.3 bits (116), Expect = 3e-05
Identities = 39/163 (23%), Positives = 57/163 (34%), Gaps = 24/163 (14%)
Query: 1352 VCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS----YMCKCAEGYGGDLCDNKND 1407
+C CR +TG C+ D C C +G A ++ ++C+C G+ G C +
Sbjct: 1289 LCVCRSAFTGRHCETFV-DVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQS--- 1344
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCL------CQPGFSGEHCQQENPCLGQVVREVIRRQ 1461
+C KC G+ + P C C+ G + CQ C Q RQ
Sbjct: 1345 ---SCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQ-------RQ 1394
Query: 1462 KGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDG 1504
Y SC A C P P + + DG
Sbjct: 1395 PPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDG 1437
Score = 48.9 bits (115), Expect = 4e-05
Identities = 39/145 (26%), Positives = 54/145 (37%), Gaps = 53/145 (36%)
Query: 1353 CECRPGWTGPLC----DQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCD----- 1403
C C+ G+ G C D+ A +PCL + G C + Y C C Y G C
Sbjct: 781 CTCKKGFKGYNCQVNIDECASNPCL----NQGTCFDDISGYTCHCVLPYTGKNCQTVLAP 836
Query: 1404 ---NKNDSANAC------SAFKC------------------------HHGQCHISDQGEP 1430
N ++A C ++ C +HG CH + QG
Sbjct: 837 CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCH-NTQGSY 895
Query: 1431 YCLCQPGFSGEHCQQE------NPC 1449
C C PGFSG C+++ NPC
Sbjct: 896 MCECPPGFSGMDCEEDIDDCLANPC 920
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 209 bits (533), Expect = 1e-53
Identities = 104/303 (34%), Positives = 140/303 (46%), Gaps = 30/303 (9%)
Query: 856 TNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVD---IN 912
T P C CS W + PG S EP +QC + +
Sbjct: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP-------------WQCNCETNWGGLL 303
Query: 913 IVAKCNACLSS-PCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH 971
N C S PC N GTC + YRC CP Y G++C + C NPC +GG+CH
Sbjct: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363
Query: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
S GF C CP G+ G C ++ D+C N C TCVD ++ + CICP + G C
Sbjct: 364 EVPS---GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
Query: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
++ C + CQH C L G+ C C G+ G+ CE + D+C + C G C D
Sbjct: 421 QLDVNDCRGQ---CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCED 477
Query: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
+G+ C CPQGFSGP CE + C+ C+NGA+C ++ + C CP F G
Sbjct: 478 LADGFHCHCPQGFSGPLCE-------VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530
Query: 1152 PRC 1154
C
Sbjct: 531 KNC 533
Score = 176 bits (445), Expect = 2e-43
Identities = 85/240 (35%), Positives = 119/240 (49%), Gaps = 14/240 (5%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
CL PC+N GTC D V+ +RC CP ++G+ C N C+ +PC G C+ D D
Sbjct: 602 CLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY--DLVND- 657
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH-C 1038
F C+C G++G+ C C+ C N TC D + + C CPP + G C + C
Sbjct: 658 FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC 717
Query: 1039 VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
+P N C + C+ FSC C G+ G+ C + +DC C +G CVD +N + C
Sbjct: 718 LP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 775
Query: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
C GF+GP C + C C GA C+ C CPPG AGPRC+++I
Sbjct: 776 ECAPGFAGPDCR-------INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
Score = 165 bits (418), Expect = 3e-40
Identities = 86/283 (30%), Positives = 121/283 (42%), Gaps = 57/283 (20%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSC 984
C++ GTC +D V Y+C CP + G+ C + + C +PC GG C + DGF C C
Sbjct: 431 CQHGGTC-KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC---EDLADGFHCHC 486
Query: 985 PLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD-----------E 1033
P GF G CE++ D CE + C N A C + +Y C CP ++ G+ C
Sbjct: 487 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACR 546
Query: 1034 VIDHCVPEL----------NLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDDCVAHK 1082
VID C + +C +C+ G FSC C G++G C + DDC+
Sbjct: 547 VIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP 606
Query: 1083 CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVL------------------------- 1117
CR+G C+D ++ + C CP G+ G C+ P L
Sbjct: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 666
Query: 1118 ------LQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
+ CD Y C NG C C CPPG+ G C
Sbjct: 667 KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 709
Score = 163 bits (413), Expect = 1e-39
Identities = 82/240 (34%), Positives = 117/240 (48%), Gaps = 17/240 (7%)
Query: 917 CNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC-IQNPCQHGGTCHLSDS 975
C+ C+ P +G+C VE ++C C ++ G C +N C +PC +GGTC ++
Sbjct: 273 CDECVPYPGCVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC--INA 326
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
D + C+CP G+ G+ CE C N C N +C + + + C CP ++G C I
Sbjct: 327 EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
D C N C C+ GF C C + G C+ D +DC +C+HG C D +NG
Sbjct: 387 DECAS--NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRG-QCQHGGTCKDLVNG 443
Query: 1096 YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
Y C CP+GF G CE L+ C C +G C + C CP GF+GP CE
Sbjct: 444 YQCVCPRGFGGRHCE-------LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 496
Score = 162 bits (410), Expect = 2e-39
Identities = 85/259 (32%), Positives = 117/259 (45%), Gaps = 16/259 (6%)
Query: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADR-LLLTTPTHRFQCKGPVDI---NI 913
P C+C W + + C S P + + +++C P N
Sbjct: 290 PWQCNCETNWGGLLC-----DKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
+AC S+PC N G+C + P + C CP + G C + I+ C NPC GGTC
Sbjct: 345 EKAEHACTSNPCANGGSCHEVPSG-FECHCPSGWSGPTCALDIDECASNPCAAGGTCV-- 401
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDE 1033
DGF C CP + G C+++ +DC C++ TC D +N Y C+CP + G C+
Sbjct: 402 -DQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
Query: 1034 VIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTI 1093
D C + C C L GF C C G+SG LCE D D C CR+GA+C +
Sbjct: 460 ERDECAS--SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE 517
Query: 1094 NGYTCTCPQGFSGPFCEHP 1112
Y C CP F G C P
Sbjct: 518 GDYYCACPDDFGGKNCSVP 536
Score = 153 bits (386), Expect = 1e-36
Identities = 91/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD----- 974
C SPC+N C + Y CACP + GK+C+VP + PC GG C + D
Sbjct: 502 CEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVP-----REPCP-GGACRVIDGCGSD 554
Query: 975 ---------------------SHKDG-FSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012
S G FSC C GF G C N DDC C N TC+
Sbjct: 555 AGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI 614
Query: 1013 DGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
D ++ + C CP + GELCD + C+P+ C +C L F C C G+ GK C
Sbjct: 615 DEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCH 672
Query: 1073 TDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE-------HPPPMV--------- 1116
+ C A+ C +G C D+ + + C CP G+ G C P P V
Sbjct: 673 SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG 732
Query: 1117 ----------------LLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
T+ C+ C NG C+ C C PGFAGP C
Sbjct: 733 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 786
Score = 149 bits (375), Expect = 3e-35
Identities = 74/194 (38%), Positives = 99/194 (51%), Gaps = 7/194 (3%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N CL PC + G C D V + CAC +KGK C C C +GGTC+ S
Sbjct: 638 NDCLPDPCHSRGRC-YDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG--- 693
Query: 978 DGFSCSCPLGFEGQRCEINPDD-CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
D F C+CP G++G C + + C N C N TCV ++ CIC + G C +
Sbjct: 694 DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN 753
Query: 1037 HCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
C P C + C+ F CEC PG++G C + D+C + C +GA CVD INGY
Sbjct: 754 DCNPLP--CYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811
Query: 1097 TCTCPQGFSGPFCE 1110
C+CP G +GP C+
Sbjct: 812 RCSCPPGRAGPRCQ 825
Score = 108 bits (270), Expect = 4e-23
Identities = 54/125 (43%), Positives = 65/125 (52%), Gaps = 10/125 (8%)
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
VAK ++CL +PC N GTC + C C ++G+ CT N C PC +GG C
Sbjct: 711 VAKNSSCLPNPCVNGGTCVGSGAS-FSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC--- 766
Query: 974 DSHKDG---FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL 1030
DG F C C GF G C IN D+C+ + C ATCVD IN Y C CPP G
Sbjct: 767 ---VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 823
Query: 1031 CDEVI 1035
C EVI
Sbjct: 824 CQEVI 828
Score = 73.6 bits (179), Expect = 1e-12
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C + T G C D+ C C PGW G C CL + C + G CV +G S+
Sbjct: 678 CDAYTCSNGGTCYD-SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------ 1444
C C +G+ G C + + N C+ C++G + C C PGF+G C+
Sbjct: 737 CICRDGWEGRTCTH---NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 793
Query: 1445 QENPC 1449
Q +PC
Sbjct: 794 QSSPC 798
Score = 67.8 bits (164), Expect = 8e-11
Identities = 40/123 (32%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH-HGKCVATGTSYMCKCAEG 1396
C++G E D+ C C GW G LCD D CL CH G+C + C C +G
Sbjct: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND-CLPDPCHSRGRCYDLVNDFYCACDDG 665
Query: 1397 YGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPY-CLCQPGFSGEHCQ-------QEN 1447
+ G C ++ C A+ C + G C+ D G+ + C C PG+ G C N
Sbjct: 666 WKGKTCHSREFQ---CDAYTCSNGGTCY--DSGDTFRCACPPGWKGSTCAVAKNSSCLPN 720
Query: 1448 PCL 1450
PC+
Sbjct: 721 PCV 723
Score = 63.2 bits (152), Expect = 2e-09
Identities = 60/203 (29%), Positives = 79/203 (38%), Gaps = 46/203 (22%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVV---CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS 1388
CK VCK G C + V C C GW G CD+ P C HG CV
Sbjct: 240 CKEA-VCKQG-CNLLHGGCTVPGECRCSYGWQGRFCDECVPYP----GCVHGSCV---EP 290
Query: 1389 YMCKCAEGYGGDLCDNKNDSANAC-SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQ- 1445
+ C C +GG LCD N C S C +G I+ + + Y C C G+SG +C++
Sbjct: 291 WQCNCETNWGGLLCDK---DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347
Query: 1446 -----ENPCLGQVVREVIRRQKGYASCATASKVPI-MECR---GGCGPQCCQPTRSKRRK 1496
NPC A+ + +VP EC G GP C
Sbjct: 348 EHACTSNPC---------------ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
Query: 1497 YVFQCTDGSSFVEEVERHLECGC 1519
C G + V++V+ EC C
Sbjct: 393 ---PCAAGGTCVDQVD-GFECIC 411
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/147 (27%), Positives = 57/147 (38%), Gaps = 25/147 (17%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
C S GLC + D C C G++GPLC+ + D C C +G +C Y
Sbjct: 464 CASSPCHSGGLCEDLA-DGFHCHCPQGFSGPLCEVDV-DLCEPSPCRNGARCYNLEGDYY 521
Query: 1391 CKCAEGYGGDLCDNKNDSA---------------------NACSAFKCHHGQCHISDQGE 1429
C C + +GG C + A S HG+C G
Sbjct: 522 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 581
Query: 1430 PYCLCQPGFSGEHCQQE-NPCLGQVVR 1455
C+C GF+G +C + + CLGQ R
Sbjct: 582 FSCICDSGFTGTYCHENIDDCLGQPCR 608
Score = 60.8 bits (146), Expect = 9e-09
Identities = 51/171 (29%), Positives = 71/171 (41%), Gaps = 32/171 (18%)
Query: 1332 CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCV-ATG 1386
C C C HG C + C C W G LCD++ H C + G C+ A
Sbjct: 273 CDECVPYPGCVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
Query: 1387 TSYMCKCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Y C C +GY G C+ + +AC++ C + G CH G C C G+SG C
Sbjct: 329 DQYRCTCPDGYSGRNCEK---AEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCAL 384
Query: 1446 E------NPCL--GQVVREV------IRRQKGYASCATASKVPIMECRGGC 1482
+ NPC G V +V Q A+C ++ + +CRG C
Sbjct: 385 DIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC----QLDVNDCRGQC 431
Score = 60.8 bits (146), Expect = 9e-09
Identities = 37/124 (29%), Positives = 48/124 (38%), Gaps = 11/124 (8%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
C S G C + D C C W G C + D C G H G C Y C
Sbjct: 389 CASNPCAAGGTCVD-QVDGFECICPEQWVGATCQLDVND-CRGQCQHGGTCKDLVNGYQC 446
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------Q 1445
C G+GG C+ + D C++ CH G +C C GFSG C+ +
Sbjct: 447 VCPRGFGGRHCELERDE---CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 503
Query: 1446 ENPC 1449
+PC
Sbjct: 504 PSPC 507
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 28/157 (17%)
Query: 1003 NDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCEC 1062
ND + TC D N C+ + G+ C E + C NL H +P + C C
Sbjct: 215 NDFFGHYTC-DQYGNKACM--DGWMGKECKEAV--CKQGCNLL-HGGCTVPGE----CRC 264
Query: 1063 VPGYSGKLCETDNDDCVAHK-CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTS 1121
G+ G+ C D+CV + C HG+ CV+ + C C + G C+ +
Sbjct: 265 SYGWQGRFC----DECVPYPGCVHGS-CVEP---WQCNCETNWGGLLCDK-------DLN 309
Query: 1122 PCDQYE-CQNGAQCIVVQQEP-TCRCPPGFAGPRCEK 1156
C + C NG CI + + C CP G++G CEK
Sbjct: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
Score = 48.1 bits (113), Expect = 6e-05
Identities = 38/140 (27%), Positives = 52/140 (37%), Gaps = 32/140 (22%)
Query: 1338 CKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH------------------ 1378
C++G C ++E D C C + G C R+PC G C
Sbjct: 507 CRNGARCYNLEGD-YYCACPDDFGGKNCSVP-REPCPGGACRVIDGCGSDAGPGMPGTAA 564
Query: 1379 ------HGKCVAT-GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY 1431
HG+CV+ G ++ C C G+ G C D C C +G I +
Sbjct: 565 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD---CLGQPCRNGGTCIDEVDAFR 621
Query: 1432 CLCQPGFSGEHCQ-QENPCL 1450
C C G+ GE C N CL
Sbjct: 622 CFCPSGWEGELCDTNPNDCL 641
Score = 32.7 bits (73), Expect = 2.8
Identities = 42/177 (23%), Positives = 62/177 (35%), Gaps = 27/177 (15%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C+S + C +G E + C C PG GP C + G C G G+S++
Sbjct: 793 CQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---FGRSCWSRGTPFPHGSSWV 848
Query: 1391 -----CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
C+C +G CS C C ++ G+P L G+ C +
Sbjct: 849 EDCNSCRCLDG------------RRDCSKVWCGWKPCLLA--GQPEALSAQCPLGQRCLE 894
Query: 1446 ENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCT 1502
+ P GQ +R G P + G C + T R +V Q T
Sbjct: 895 KAP--GQCLRPPCEAW-GECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGT 948
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 204 bits (518), Expect = 7e-52
Identities = 168/642 (26%), Positives = 257/642 (40%), Gaps = 87/642 (13%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C S+ C + TC D V + C CP+ G C + + CI NPC G C + +
Sbjct: 339 CASAACFHGATC-HDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGKA 396
Query: 980 FSCSCPLGFEGQRCEINPDDCE--DNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
C+CP G+ G C + D+C N CE+ C++ + ++ C C YTG C+ ++
Sbjct: 397 I-CTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNE 455
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
CV N CQ++A C+ F C C+PGY G CE + D+C + C H +C+D IN +
Sbjct: 456 CVS--NPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQ 513
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKL 1157
C CP GF+G C++ C C+NGA+C+ TC C G+ G CE
Sbjct: 514 CECPTGFTGHLCQY-------DVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD 566
Query: 1158 I------TVNFVGKDSYVELASAKVRP-------QANISL---------QVATDKDNGIL 1195
I ++ V + RP + NI+ D+DN L
Sbjct: 567 IDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYL 626
Query: 1196 LY--KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLV 1253
+ KG P + + D +S P + DG + E N+
Sbjct: 627 CFCLKGTTGP--------NCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNIN 678
Query: 1254 VDK--GTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRI 1311
+D+ G P G + G G T LS + + P C+H
Sbjct: 679 IDECAGNPCHNGGTCEDGINGFTCRC-PEGYHDPTCLSEVNECNSNP------CVHGA-C 730
Query: 1312 NNELQDFKA-LPPQSLGV-----SPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLC- 1364
+ L +K P G + C+S G C+ + VC CR G++GP C
Sbjct: 731 RDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDM-TSGYVCTCREGFSGPNCQ 789
Query: 1365 ---DQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHH-G 1420
++ A +PCL + G C+ Y C C Y G C+ C+ C + G
Sbjct: 790 TNINECASNPCL----NQGTCIDDVAGYKCNCLLPYTGATCE---VVLAPCAPSPCRNGG 842
Query: 1421 QCHISDQGEPY-CLCQPGFSGEHCQQE-NPCLGQVVREVIRRQKGYASCATASKVPIMEC 1478
+C S+ E + C+C G+ G+ C+ + N C V+ + ASC C
Sbjct: 843 ECRQSEDYESFSCVCPTGWQGQTCEVDINEC-------VLSPCRHGASCQNTHGGYRCHC 895
Query: 1479 RGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCL 1520
+ G + C+ R C +G S + + C CL
Sbjct: 896 QAGYSGRNCETDIDDCRPN--PCHNGGSCTDGINTAF-CDCL 934
Score = 194 bits (492), Expect = 7e-49
Identities = 92/243 (37%), Positives = 123/243 (50%), Gaps = 15/243 (6%)
Query: 918 NACLSSP--CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS 975
N C P C++ GTC + V YRC C ++ G +C P C +PCQ+GGTC +
Sbjct: 180 NECGQKPGLCRHGGTCHNE-VGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGD 238
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
C+C GF GQ CE N DDC N+C+N CVDG+N Y C CPP +TG+ C E +
Sbjct: 239 VTH--ECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDV 296
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
D C N CQ+ C G++C CV G++G+ C + DDC + C HGA C D +
Sbjct: 297 DECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVAS 356
Query: 1096 YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIV--VQQEPTCRCPPGFAGPR 1153
+ C CP G +G C C C G+ C V + C CP G+ GP
Sbjct: 357 FYCECPHGRTGLLCH--------LNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA 408
Query: 1154 CEK 1156
C +
Sbjct: 409 CSQ 411
Score = 188 bits (478), Expect = 3e-47
Identities = 92/248 (37%), Positives = 124/248 (50%), Gaps = 24/248 (9%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTC-HLSDSHKD 978
C SPC+N TCT D + Y C C Y G +C+ I+ C+ +PCQ+GGTC L +++K
Sbjct: 1149 CSPSPCQNGATCT-DYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYK- 1206
Query: 979 GFSCSCPLGFEGQRCEINPDDCE--------DNDCENNATCVDGINNYVCICPPNYTGEL 1030
CSCP G +G CEIN DDC C NN TCVD + Y C CPP + GE
Sbjct: 1207 ---CSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGER 1263
Query: 1031 CDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCV 1090
C+ ++ C+ + C+ F CEC G++G+ CE+ + C C++G C
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCA 1323
Query: 1091 ---DTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPP 1147
+T G+ C CP GF G CE+ C C NG CI + PTC C
Sbjct: 1324 VASNTARGFICKCPAGFEGATCEN-------DARTCGSLRCLNGGTCISGPRSPTCLCLG 1376
Query: 1148 GFAGPRCE 1155
F GP C+
Sbjct: 1377 PFTGPECQ 1384
Score = 188 bits (477), Expect = 4e-47
Identities = 92/253 (36%), Positives = 130/253 (51%), Gaps = 25/253 (9%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S PC + GTC QD YRC CP Y G +C ++ C +PC++GG C + +
Sbjct: 1023 NECDSQPCLHGGTC-QDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ- 1080
Query: 978 DGFSCSCPLGFEGQRCEINPDDCE----------DNDCENNATCVDGINNYVCICPPNYT 1027
+ C CP G+ G C++ CE C++ CVD N + C C YT
Sbjct: 1081 --YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYT 1138
Query: 1028 GELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGA 1087
G C++++D C P + CQ+ A C G+SC+CV GY G C + D+C++H C++G
Sbjct: 1139 GSYCEDLVDECSP--SPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGG 1196
Query: 1088 QCVDTINGYTCTCPQGFSGPFCE-----HPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT 1142
C+D N Y C+CP+G G CE PP+ + SP +C N C+ +
Sbjct: 1197 TCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP----KCFNNGTCVDQVGGYS 1252
Query: 1143 CRCPPGFAGPRCE 1155
C CPPGF G RCE
Sbjct: 1253 CTCPPGFVGERCE 1265
Score = 185 bits (469), Expect = 3e-46
Identities = 104/311 (33%), Positives = 145/311 (46%), Gaps = 36/311 (11%)
Query: 856 TNPLH----CDCSLRWLSEWVKAGYKEPGIAR----CS---SPEPMADRLLLTTPTHRFQ 904
TNP++ C C +GY P ++ CS +P A + + T + Q
Sbjct: 389 TNPVNGKAICTCP---------SGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQ 439
Query: 905 C-KGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP 963
C +G N C+S+PC+N+ TC D + ++C C Y+G C V + C +P
Sbjct: 440 CLQGYTGPRCEIDVNECVSNPCQNDATCL-DQIGEFQCICMPGYEGVHCEVNTDECASSP 498
Query: 964 CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICP 1023
C H G C + F C CP GF G C+ + D+C C+N A C+DG N Y C+C
Sbjct: 499 CLHNGRCL---DKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCT 555
Query: 1024 PNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKC 1083
YTG C+ ID C P+ C H C F+C C PGY+G CET+ ++C + C
Sbjct: 556 EGYTGTHCEVDIDECDPD--PC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPC 612
Query: 1084 RHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTC 1143
RHG C D N Y C C +G +GP CE + C C +G C+ C
Sbjct: 613 RHGGTCQDRDNAYLCFCLKGTTGPNCE-------INLDDCASSPCDSGT-CLDKIDGYEC 664
Query: 1144 RCPPGFAGPRC 1154
C PG+ G C
Sbjct: 665 ACEPGYTGSMC 675
Score = 182 bits (463), Expect = 2e-45
Identities = 94/259 (36%), Positives = 129/259 (49%), Gaps = 19/259 (7%)
Query: 903 FQCKGPV---DINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC 959
F C+ P D +++ N C S+PC + G C +D + Y+C C + G +C + N C
Sbjct: 700 FTCRCPEGYHDPTCLSEVNECNSNPCVH-GAC-RDSLNGYKCDCDPGWSGTNCDINNNEC 757
Query: 960 IQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYV 1019
NPC +GGTC S G+ C+C GF G C+ N ++C N C N TC+D + Y
Sbjct: 758 ESNPCVNGGTCKDMTS---GYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYK 814
Query: 1020 CICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLD--KGFSCECVPGYSGKLCETDNDD 1077
C C YTG C+ V+ C P + C++ +C + + FSC C G+ G+ CE D ++
Sbjct: 815 CNCLLPYTGATCEVVLAPCAP--SPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINE 872
Query: 1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVV 1137
CV CRHGA C +T GY C C G+SG CE C C NG C
Sbjct: 873 CVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCE-------TDIDDCRPNPCHNGGSCTDG 925
Query: 1138 QQEPTCRCPPGFAGPRCEK 1156
C C PGF G CE+
Sbjct: 926 INTAFCDCLPGFRGTFCEE 944
Score = 182 bits (461), Expect = 3e-45
Identities = 95/302 (31%), Positives = 138/302 (45%), Gaps = 14/302 (4%)
Query: 861 CDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCK-GPVDINIVAKCNA 919
C C W + + E ++ C + T +R C+ G N +
Sbjct: 855 CVCPTGWQGQTCEVDINECVLSPCRHGASCQN----THGGYRCHCQAGYSGRNCETDIDD 910
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C +PC N G+CT D + C C ++G C IN C +PC++G C D
Sbjct: 911 CRPNPCHNGGSCT-DGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANC---TDCVDS 966
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
++C+CP GF G CE N DC ++ C N TCVDGIN++ C+CPP +TG C ++ C
Sbjct: 967 YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNEC- 1025
Query: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCT 1099
+ C H C + C C GY+G C+ C + C++G +C T Y C
Sbjct: 1026 -DSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCE 1084
Query: 1100 CPQGFSGPFCEHPPPM--VLLQTSPCDQYE-CQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
CP G++G +C+ P V Q D CQ+G C+ CRC G+ G CE
Sbjct: 1085 CPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCED 1144
Query: 1157 LI 1158
L+
Sbjct: 1145 LV 1146
Score = 177 bits (449), Expect = 7e-44
Identities = 94/298 (31%), Positives = 133/298 (44%), Gaps = 53/298 (17%)
Query: 900 THRFQC-KGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT 958
TH C G N + C + CKN G C D V Y C CP + G+ CT ++
Sbjct: 240 THECACLPGFTGQNCEENIDDCPGNNCKNGGACV-DGVNTYNCRCPPEWTGQYCTEDVDE 298
Query: 959 C--IQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
C + N CQ+GGTCH ++H G++C C G+ G+ C N DDC C + ATC D +
Sbjct: 299 CQLMPNACQNGGTCH--NTH-GGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVA 355
Query: 1017 NY---------------------------------------VCICPPNYTGELCDEVIDH 1037
++ +C CP YTG C + +D
Sbjct: 356 SFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDE 415
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C N C+H KCI F C+C+ GY+G CE D ++CV++ C++ A C+D I +
Sbjct: 416 CSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQ 475
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
C C G+ G CE + T C C + +C+ E C CP GF G C+
Sbjct: 476 CICMPGYEGVHCE-------VNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQ 526
Score = 177 bits (448), Expect = 9e-44
Identities = 87/241 (36%), Positives = 118/241 (48%), Gaps = 15/241 (6%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S PC++ GTC QD Y C C G +C + ++ C +PC GTC
Sbjct: 605 NECSSQPCRHGGTC-QDRDNAYLCFCLKGTTGPNCEINLDDCASSPCD-SGTCL---DKI 659
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
DG+ C+C G+ G C IN D+C N C N TC DGIN + C CP Y C ++
Sbjct: 660 DGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNE 719
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C N C H A C G+ C+C PG+SG C+ +N++C ++ C +G C D +GY
Sbjct: 720 C--NSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYV 776
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKL 1157
CTC +GFSGP C+ + C C N CI C C + G CE +
Sbjct: 777 CTCREGFSGPNCQ-------TNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVV 829
Query: 1158 I 1158
+
Sbjct: 830 L 830
Score = 172 bits (436), Expect = 2e-42
Identities = 89/261 (34%), Positives = 123/261 (47%), Gaps = 25/261 (9%)
Query: 901 HRFQCKGPVDIN---IVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPIN 957
+ FQC+ P + C S+PCKN C P Y C C Y G C V I+
Sbjct: 510 NEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGP-NTYTCVCTEGYTGTHCEVDID 568
Query: 958 TCIQNPCQHGGTCHLSDSHKDG---FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDG 1014
C +PC H G+C KDG F+C C G+ G CE N ++C C + TC D
Sbjct: 569 ECDPDPC-HYGSC------KDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDR 621
Query: 1015 INNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETD 1074
N Y+C C TG C+ +D C + C C+ G+ C C PGY+G +C +
Sbjct: 622 DNAYLCFCLKGTTGPNCEINLDDCAS--SPCD-SGTCLDKIDGYECACEPGYTGSMCNIN 678
Query: 1075 NDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQC 1134
D+C + C +G C D ING+TC CP+G+ P C L + + C+ C +GA C
Sbjct: 679 IDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTC-------LSEVNECNSNPCVHGA-C 730
Query: 1135 IVVQQEPTCRCPPGFAGPRCE 1155
C C PG++G C+
Sbjct: 731 RDSLNGYKCDCDPGWSGTNCD 751
Score = 171 bits (434), Expect = 4e-42
Identities = 99/271 (36%), Positives = 127/271 (46%), Gaps = 34/271 (12%)
Query: 907 GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC------- 959
GP N+V C+ SSPCKN G C Q + YRC CP + G C VP +C
Sbjct: 1053 GPNCQNLVHWCD---SSPCKNGGKCWQTHTQ-YRCECPSGWTGLYCDVPSVSCEVAAQRQ 1108
Query: 960 ---IQNPCQHGGTC-HLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGI 1015
+ CQHGG C ++H C C G+ G CE D+C + C+N ATC D +
Sbjct: 1109 GVDVARLCQHGGLCVDAGNTHH----CRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYL 1164
Query: 1016 NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN 1075
Y C C Y G C E ID C+ + CQ+ C+ L + C C G G CE +
Sbjct: 1165 GGYSCKCVAGYHGVNCSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINV 1222
Query: 1076 DDCV--------AHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYE 1127
DDC + KC + CVD + GY+CTCP GF G CE L ++PCD
Sbjct: 1223 DDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECL--SNPCDARG 1280
Query: 1128 CQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
QN C+ + C C G G RCE +I
Sbjct: 1281 TQN---CVQRVNDFHCECRAGHTGRRCESVI 1308
Score = 167 bits (422), Expect = 9e-41
Identities = 88/284 (30%), Positives = 127/284 (44%), Gaps = 51/284 (17%)
Query: 918 NACLSSPCKNNGTC---TQDPVELYRCACPYSYKGKDCTVPI-NTCIQNPCQHGGTCHLS 973
N CLS+PCKN GTC + V Y C+C + G C P+ N C+ NPC++GGTC L
Sbjct: 61 NPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLL 120
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDE 1033
+ + C CP G+ G+ C+ D C N C N C+ +Y+C CPP++ G C +
Sbjct: 121 TLTE--YKCRCPPGWSGKSCQ-QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQ 177
Query: 1034 VIDHCVPELNLCQHEAKC------------------------IPL--------------- 1054
++ C + LC+H C +P
Sbjct: 178 DVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG 237
Query: 1055 DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPP 1114
D C C+PG++G+ CE + DDC + C++G CVD +N Y C CP ++G +C
Sbjct: 238 DVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVD 297
Query: 1115 MVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
L + C QNG C C C G+ G C + I
Sbjct: 298 ECQLMPNAC-----QNGGTCHNTHGGYNCVCVNGWTGEDCSENI 336
Score = 162 bits (409), Expect = 3e-39
Identities = 100/319 (31%), Positives = 143/319 (44%), Gaps = 35/319 (10%)
Query: 857 NPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCK---GPVDINI 913
N HC C + Y E + CS P P + T + CK G +N
Sbjct: 1127 NTHHCRCQAGYTGS-----YCEDLVDECS-PSPCQNGATCTDYLGGYSCKCVAGYHGVNC 1180
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKG-------KDCTVPINTCIQNP-CQ 965
+ + CLS PC+N GTC P Y+C+CP +G DC P++ ++P C
Sbjct: 1181 SEEIDECLSHPCQNGGTCLDLP-NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCF 1239
Query: 966 HGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNAT--CVDGINNYVCICP 1023
+ GTC G+SC+CP GF G+RCE + ++C N C+ T CV +N++ C C
Sbjct: 1240 NNGTCV---DQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECR 1296
Query: 1024 PNYTGELCDEVIDHCVPELNLCQHEAKCIPLD---KGFSCECVPGYSGKLCETDNDDCVA 1080
+TG C+ VI+ C + C++ C +GF C+C G+ G CE D C +
Sbjct: 1297 AGHTGRRCESVINGCKGKP--CKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGS 1354
Query: 1081 HKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQE 1140
+C +G C+ TC C F+GP C+ P L +P C N C +
Sbjct: 1355 LRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNP-----CYNQGTCEPTSES 1409
Query: 1141 P--TCRCPPGFAGPRCEKL 1157
P C CP F G C L
Sbjct: 1410 PFYRCLCPAKFNGLLCHIL 1428
Score = 151 bits (382), Expect = 4e-36
Identities = 84/245 (34%), Positives = 112/245 (45%), Gaps = 28/245 (11%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG-FSCS 983
C N G C + C C ++ G C P N C+ PC++ GTCH+ D ++CS
Sbjct: 31 CLNGGKC-EAANGTEACVCGGAFVGPRCQDP-NPCLSTPCKNAGTCHVVDRRGVADYACS 88
Query: 984 CPLGFEGQRCEINPDD-CEDNDCENNATC-VDGINNYVCICPPNYTGELCDEVIDHCVPE 1041
C LGF G C D+ C N C N TC + + Y C CPP ++G+ C + D C
Sbjct: 89 CALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQA-DPCAS- 146
Query: 1042 LNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHK--CRHGAQCVDTINGYTCT 1099
N C + +C+P + + C C P + G C D ++C CRHG C + + Y C
Sbjct: 147 -NPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCV 205
Query: 1100 CPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT------CRCPPGFAGPR 1153
C +GP CE P PC CQNG C PT C C PGF G
Sbjct: 206 CRATHTGPNCERP-------YVPCSPSPCQNGGTC-----RPTGDVTHECACLPGFTGQN 253
Query: 1154 CEKLI 1158
CE+ I
Sbjct: 254 CEENI 258
Score = 96.7 bits (239), Expect = 2e-19
Identities = 55/177 (31%), Positives = 79/177 (44%), Gaps = 22/177 (12%)
Query: 986 LGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLC 1045
L G RC P + C N C C+C + G C + + C+ C
Sbjct: 17 LAARGPRCS-QPGET----CLNGGKCEAANGTEACVCGGAFVGPRCQDP-NPCLS--TPC 68
Query: 1046 QHEAKCIPLDK----GFSCECVPGYSGKLCETDNDD-CVAHKCRHGAQC-VDTINGYTCT 1099
++ C +D+ ++C C G+SG LC T D+ C+ + CR+G C + T+ Y C
Sbjct: 69 KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCR 128
Query: 1100 CPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
CP G+SG C+ Q PC C NG QC+ + C CPP F GP C +
Sbjct: 129 CPPGWSGKSCQ--------QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQ 177
Score = 70.9 bits (172), Expect = 9e-12
Identities = 39/105 (37%), Positives = 50/105 (47%), Gaps = 10/105 (9%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVA----TGTSYMCKCAEGYGGDLCDNKNDS 1408
CECR G TG C+ C G C +G A T ++CKC G+ G C+N
Sbjct: 1293 CECRAGHTGRRCESVING-CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCEN---D 1348
Query: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ--QENPCLG 1451
A C + +C +G IS P CLC F+G CQ +PCLG
Sbjct: 1349 ARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLG 1393
Score = 68.6 bits (166), Expect = 5e-11
Identities = 39/118 (33%), Positives = 50/118 (42%), Gaps = 7/118 (5%)
Query: 1341 GLCRSVEK-DSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEGYG 1398
G CR E +S C C GW G C+ + + C+ C HG C T Y C C GY
Sbjct: 842 GECRQSEDYESFSCVCPTGWQGQTCEVDINE-CVLSPCRHGASCQNTHGGYRCHCQAGYS 900
Query: 1399 GDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQVVR 1455
G C+ D C CH+G +C C PGF G C+++ N C R
Sbjct: 901 GRNCETDIDD---CRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCR 955
Score = 68.2 bits (165), Expect = 6e-11
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 11/109 (10%)
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEGYGGDLCDNKND 1407
++ C+C PG+ G C+++ + C C +G C SY C C G+ G C+N
Sbjct: 927 NTAFCDCLPGFRGTFCEEDINE-CASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTP 985
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE------NPCL 1450
C+ C +G + CLC PGF+G +CQ + PCL
Sbjct: 986 D---CTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCL 1031
Score = 67.0 bits (162), Expect = 1e-10
Identities = 46/138 (33%), Positives = 57/138 (41%), Gaps = 13/138 (9%)
Query: 1320 ALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC 1377
AL P P C T G C + + C C + GP C +PCL C
Sbjct: 12 ALLPALAARGPRCSQPGETCLNGGKCEAAN-GTEACVCGGAFVGPRCQDP--NPCLSTPC 68
Query: 1378 HH-GKCVATG----TSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPY 1431
+ G C Y C CA G+ G LC D NAC C +G C + E
Sbjct: 69 KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLD--NACLTNPCRNGGTCDLLTLTEYK 126
Query: 1432 CLCQPGFSGEHCQQENPC 1449
C C PG+SG+ CQQ +PC
Sbjct: 127 CRCPPGWSGKSCQQADPC 144
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/134 (31%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 1328 VSPGCKS-----CTVCKH-GLCRSVEKDSVV---CECRPGWTGPLCDQEARDPCLGHRCH 1378
V P C+ T CK+ G C V++ V C C G++GPLC + CL + C
Sbjct: 53 VGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCR 112
Query: 1379 HGKC--VATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQP 1436
+G + T T Y C+C G+ G C A+ C++ C +G + + C C P
Sbjct: 113 NGGTCDLLTLTEYKCRCPPGWSGKSCQQ----ADPCASNPCANGGQCLPFEASYICHCPP 168
Query: 1437 GFSGEHCQQE-NPC 1449
F G C+Q+ N C
Sbjct: 169 SFHGPTCRQDVNEC 182
Score = 66.6 bits (161), Expect = 2e-10
Identities = 52/206 (25%), Positives = 77/206 (37%), Gaps = 23/206 (11%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEG 1396
C++G + C+C G+ G C +E D CL H C +G C+ +Y C C G
Sbjct: 1154 CQNGATCTDYLGGYSCKCVAGYHGVNCSEEI-DECLSHPCQNGGTCLDLPNTYKCSCPRG 1212
Query: 1397 YGGDLCDNKNDSAN-----ACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE----- 1446
G C+ D N + KC + + G C C PGF GE C+ +
Sbjct: 1213 TQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECL 1272
Query: 1447 -NPCLGQVVREVIRRQKGYASCATASKVPIMECR---GGC-GPQC-----CQPTRSKRRK 1496
NPC + + ++R + C + C GC G C C + R
Sbjct: 1273 SNPCDARGTQNCVQRVNDF-HCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARG 1331
Query: 1497 YVFQCTDGSSFVEEVERHLECGCLAC 1522
++ +C G CG L C
Sbjct: 1332 FICKCPAGFEGATCENDARTCGSLRC 1357
Score = 65.1 bits (157), Expect = 5e-10
Identities = 44/163 (26%), Positives = 65/163 (39%), Gaps = 21/163 (12%)
Query: 1305 CIHEVRINNELQDFKALPPQSLGVSPGCKSC------TVCKHGLCRSVEKDSVVCECRPG 1358
C+H + ++ PQ P C++ + CK+G CEC G
Sbjct: 1030 CLHGGTCQDGCGSYRCTCPQGY-TGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSG 1088
Query: 1359 WTGPLCD---------QEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLCDNKNDS 1408
WTG CD + + + C HG CV G ++ C+C GY G C+ D
Sbjct: 1089 WTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCE---DL 1145
Query: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCL 1450
+ CS C +G G C C G+ G +C +E + CL
Sbjct: 1146 VDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECL 1188
Score = 64.3 bits (155), Expect = 9e-10
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 19/153 (12%)
Query: 1305 CIHEVRINNELQDFKALPPQSLGVSPGCK------SCTVCKHG-LCRSVEKDSVVCECRP 1357
C H +NE+ ++ + ++ P C+ S + C++G CR + C C P
Sbjct: 189 CRHGGTCHNEVGSYRCVC-RATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLP 247
Query: 1358 GWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDSA----NAC 1412
G+TG C++ D C G+ C + G CV +Y C+C + G C D NAC
Sbjct: 248 GFTGQNCEENI-DDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNAC 306
Query: 1413 SAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
+ G CH + G C+C G++GE C +
Sbjct: 307 Q----NGGTCH-NTHGGYNCVCVNGWTGEDCSE 334
Score = 61.2 bits (147), Expect = 7e-09
Identities = 53/201 (26%), Positives = 77/201 (38%), Gaps = 37/201 (18%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPC--LGHRCHHG-KCVATGTS 1388
CK+ C G+ ++ C C P WTG C ++ D C + + C +G C T
Sbjct: 266 CKNGGACVDGV------NTYNCRCPPEWTGQYCTEDV-DECQLMPNACQNGGTCHNTHGG 318
Query: 1389 YMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENP 1448
Y C C G+ G+ C D C++ C HG YC C G +G C +
Sbjct: 319 YNCVCVNGWTGEDCSENIDD---CASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDA 375
Query: 1449 CLGQVVREVIRRQKGYASCAT--ASKVPIMECRGG-CGPQCCQPTRSKRRKYVFQCTDGS 1505
C+ E ++C T + I C G GP C Q V +C+ G+
Sbjct: 376 CISNPCNE-------GSNCDTNPVNGKAICTCPSGYTGPACSQD--------VDECSLGA 420
Query: 1506 SFVEEVER------HLECGCL 1520
+ E + EC CL
Sbjct: 421 NPCEHAGKCINTLGSFECQCL 441
Score = 58.5 bits (140), Expect = 5e-08
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEG 1396
C++G + DS C C G++G C+ D C C + G CV S+ C C G
Sbjct: 954 CRNGANCTDCVDSYTCTCPAGFSGIHCENNTPD-CTESSCFNGGTCVDGINSFTCLCPPG 1012
Query: 1397 YGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
+ G C + N C + C HG G C C G++G +CQ
Sbjct: 1013 FTGSYCQH---DVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQ 1057
Score = 57.8 bits (138), Expect = 8e-08
Identities = 82/312 (26%), Positives = 108/312 (34%), Gaps = 82/312 (26%)
Query: 840 EGSFNDLTSLSHLALGT-------NPLHCDCSLRWLSEWVKAGYK----EPGIARCSS-P 887
EG N+ S A GT N HC+C +AG+ E I C P
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVNDFHCEC---------RAGHTGRRCESVINGCKGKP 1315
Query: 888 EPMADRLLLTTPTHR-FQCKGPVDINIVAKCN----ACLSSPCKNNGTCTQDPVELYRCA 942
+ + T R F CK P A C C S C N GTC P C
Sbjct: 1316 CKNGGTCAVASNTARGFICKCPAGFE-GATCENDARTCGSLRCLNGGTCISGP-RSPTCL 1373
Query: 943 CPYSYKGKDCTVPINT-CIQ-NPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINP--- 997
C + G +C P ++ C+ NPC + GTC + S + C CP F G C I
Sbjct: 1374 CLGPFTGPECQFPASSPCLGGNPCYNQGTCEPT-SESPFYRCLCPAKFNGLLCHILDYSF 1432
Query: 998 --------------DDCEDNDCENNA---TCVDGINNYVC-----ICPPNYTG--ELCDE 1033
+ CE +C+ +A C NN+ C C N+ + C +
Sbjct: 1433 GGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQ 1492
Query: 1034 VID--------HCVPELNL---------CQH-EAKCIPL------DKGFSCECVPGYSGK 1069
+ HC + N CQ E +C PL D C G +
Sbjct: 1493 SLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSA 1552
Query: 1070 LCETDNDDCVAH 1081
CE D DC H
Sbjct: 1553 ECEWDGLDCAEH 1564
Score = 57.4 bits (137), Expect = 1e-07
Identities = 36/122 (29%), Positives = 53/122 (43%), Gaps = 11/122 (9%)
Query: 1327 GVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVAT 1385
G PG +C+HG E S C CR TGP C++ PC C + G C T
Sbjct: 183 GQKPG-----LCRHGGTCHNEVGSYRCVCRATHTGPNCER-PYVPCSPSPCQNGGTCRPT 236
Query: 1386 G-TSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
G ++ C C G+ G C+ D C C +G + C C P ++G++C
Sbjct: 237 GDVTHECACLPGFTGQNCEENIDD---CPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 293
Query: 1445 QE 1446
++
Sbjct: 294 ED 295
Score = 41.6 bits (96), Expect = 0.006
Identities = 28/75 (37%), Positives = 34/75 (45%), Gaps = 5/75 (6%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL-GHRCHH-GKCVATGTS- 1388
C S G C S + S C C +TGP C A PCL G+ C++ G C T S
Sbjct: 1352 CGSLRCLNGGTCISGPR-SPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESP 1410
Query: 1389 -YMCKCAEGYGGDLC 1402
Y C C + G LC
Sbjct: 1411 FYRCLCPAKFNGLLC 1425
Score = 33.1 bits (74), Expect = 2.1
Identities = 21/74 (28%), Positives = 31/74 (41%), Gaps = 11/74 (14%)
Query: 1420 GQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREV----IRRQKGYASCATASKVPI 1475
G+C ++ G C+C F G CQ NPCL + + ++G A A + +
Sbjct: 35 GKCEAAN-GTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCAL-- 91
Query: 1476 MECRGGCGPQCCQP 1489
G GP C P
Sbjct: 92 ----GFSGPLCLTP 101
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 203 bits (516), Expect = 1e-51
Identities = 112/324 (34%), Positives = 146/324 (45%), Gaps = 45/324 (13%)
Query: 850 SHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTP-THRFQCKGP 908
S + GT C C G++ P CS P+P L++P H +C
Sbjct: 95 SSVVAGTARFSCRCP---------RGFRGPD---CSLPDPC-----LSSPCAHGARCSVG 137
Query: 909 VDINIVAKC------NACLSS--------PCKNNGTCTQDPVELYRCACPYSYKGKDCTV 954
D + C +C S PC++ GTC P +RC CP Y G C
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS-FRCQCPAGYTGPLCEN 196
Query: 955 PINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDG 1014
P C +PC++GGTC S + C+C GFEGQ CE+N DDC + C N TCVDG
Sbjct: 197 PAVPCAPSPCRNGGTCRQSGDLT--YDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDG 254
Query: 1015 INNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETD 1074
+N Y C CPP +TG+ C E +D C + N C + C G SC CV G++G+ C +
Sbjct: 255 VNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQN 314
Query: 1075 NDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQC 1134
DDC C HGA C D + + C CP G +G C C C A C
Sbjct: 315 IDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCH--------LDDACVSNPCHEDAIC 366
Query: 1135 IV--VQQEPTCRCPPGFAGPRCEK 1156
V C CPPGF G C++
Sbjct: 367 DTNPVNGRAICTCPPGFTGGACDQ 390
Score = 194 bits (492), Expect = 7e-49
Identities = 91/237 (38%), Positives = 124/237 (52%), Gaps = 15/237 (6%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N CLS PC+N TC D + + C C + G C V I+ C +PC +GG C
Sbjct: 433 NECLSGPCRNQATCL-DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK---DRV 488
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
+GFSC+CP GF G C+++ D+C C N A CVD + Y C C + G LCD +D
Sbjct: 489 NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDD 548
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C P+ C H +C+ FSC C PGY+G CE+ D+C + CRHG +C+D ++ Y
Sbjct: 549 CSPDP--CHH-GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
C CP G +G CE + ++PC C++G C C PGF GP C
Sbjct: 606 CRCPSGTTGVNCE--VNIDDCASNPCTFGVCRDGI------NRYDCVCQPGFTGPLC 654
Score = 180 bits (456), Expect = 1e-44
Identities = 97/303 (32%), Positives = 138/303 (45%), Gaps = 24/303 (7%)
Query: 861 CDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDIN--IVAKCN 918
C C W E + A C DR+ F C P+ + +
Sbjct: 300 CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVA------SFYCACPMGKTGLLCHLDD 353
Query: 919 ACLSSPCKNNGTCTQDPVELYR-CACPYSYKGKDCTVPINTCI--QNPCQHGGTCHLSDS 975
AC+S+PC + C +PV C CP + G C ++ C NPC+H G C +
Sbjct: 354 ACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV---N 410
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
+ F C C G+ G RCE + ++C C N ATC+D I + CIC +TG C+ I
Sbjct: 411 TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDI 470
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
D C + + C + C GFSC C G+SG C+ D D+C + CR+GA+CVD +G
Sbjct: 471 DEC--QSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG 528
Query: 1096 YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
Y C C +GF G C+ C C +G +C+ +C C PG+ G RCE
Sbjct: 529 YECRCAEGFEGTLCDR-------NVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCE 580
Query: 1156 KLI 1158
+
Sbjct: 581 SQV 583
Score = 178 bits (452), Expect = 3e-44
Identities = 99/309 (32%), Positives = 136/309 (44%), Gaps = 34/309 (11%)
Query: 861 CDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCK---GPVDINIVAKC 917
C C W + E C+ P P + T F C G +
Sbjct: 796 CSCPQGWQGPRCQQDVDE-----CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C +PC N G+C QD V + C+C + G C ++ C+ NPC G TC H
Sbjct: 851 NDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TC---TDHV 905
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
F+C+CP G+ G CE + DC + C N TCVDG+N++ C+C P YTG C D
Sbjct: 906 ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C+ C H C GF C C+ ++G C+T D C C++G +CV T G
Sbjct: 966 CLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAY 1021
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYE----------CQNGAQCIVVQQEPTCRCPP 1147
C CP G+SG C+ +++ PC + CQ G QC+ C CP
Sbjct: 1022 CLCPPGWSGRLCD-------IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPE 1074
Query: 1148 GFAGPRCEK 1156
G G CE+
Sbjct: 1075 GRTGSHCEQ 1083
Score = 178 bits (451), Expect = 4e-44
Identities = 91/259 (35%), Positives = 122/259 (47%), Gaps = 30/259 (11%)
Query: 915 AKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD 974
A+ L C+ G C + Y C CP G C ++ C+ PCQHGGTC
Sbjct: 1045 AQIGVRLEQLCQAGGQCVDEDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCR--- 1100
Query: 975 SHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEV 1034
+ G+ C C G+ G CE + D+C C++ +C+D + Y+C CPP G LC+
Sbjct: 1101 GYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEIN 1160
Query: 1035 IDHCVPELNL-----CQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCR--HGA 1087
D C P L C H C+ L GF C C PGY+G CE D ++C + C H
Sbjct: 1161 EDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTR 1220
Query: 1088 QCV-DTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEP----- 1141
C+ D G+ C C GFSGP C+ SPC+ CQ+G QC + P
Sbjct: 1221 DCLQDPGGGFRCLCHAGFSGPRCQ-------TVLSPCESQPCQHGGQC---RPSPGPGGG 1270
Query: 1142 ---TCRCPPGFAGPRCEKL 1157
TC C F GPRCE++
Sbjct: 1271 LTFTCHCAQPFWGPRCERV 1289
Score = 174 bits (441), Expect = 6e-43
Identities = 92/274 (33%), Positives = 125/274 (45%), Gaps = 52/274 (18%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C SSPC N G C +D V + C CP + G C + ++ C PC++G C DG
Sbjct: 473 CQSSPCVNGGVC-KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCV---DQPDG 528
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
+ C C GFEG C+ N DDC + C ++ CVDGI ++ C C P YTG C+ +D C
Sbjct: 529 YECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECR 587
Query: 1040 PELNLCQHEAKCIPL-DK----------GFSCE--------------------------C 1062
+ C+H KC+ L DK G +CE C
Sbjct: 588 SQP--CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVC 645
Query: 1063 VPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSP 1122
PG++G LC + ++C + C G CVD NG+ C CP G P C P + P
Sbjct: 646 QPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPP-------SHP 698
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
C C +G C C C PG++GPRC +
Sbjct: 699 CAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRCSQ 731
Score = 172 bits (436), Expect = 2e-42
Identities = 85/254 (33%), Positives = 124/254 (48%), Gaps = 26/254 (10%)
Query: 916 KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS 975
+ + CLS PC + G C+ +RC C S+ G C ++ C + PCQ+GG C
Sbjct: 962 EADPCLSRPCLHGGVCSAAHPG-FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCV---- 1016
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDND----------CENNATCVDGINNYVCICPPN 1025
+ G C CP G+ G+ C+I C + C+ CVD +++ C+CP
Sbjct: 1017 -QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG 1075
Query: 1026 YTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRH 1085
TG C++ +D C+ + CQH C G+ CEC+PGY+G CE D D+C + C+H
Sbjct: 1076 RTGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQH 1133
Query: 1086 GAQCVDTINGYTCTCPQGFSGPFCE----HPPPMVLLQTSPCDQYECQNGAQCIVVQQEP 1141
G C+D + Y C+CP G G CE P L + P C + C+ +
Sbjct: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGP----RCLHNGTCVDLVGGF 1189
Query: 1142 TCRCPPGFAGPRCE 1155
C CPPG+ G RCE
Sbjct: 1190 RCTCPPGYTGLRCE 1203
Score = 172 bits (435), Expect = 3e-42
Identities = 82/233 (35%), Positives = 118/233 (50%), Gaps = 14/233 (6%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSC 984
C N GTC + + + C C + G+ C+ I+ C C HG TCH F C+C
Sbjct: 285 CHNGGTCF-NTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCH---DRVASFYCAC 340
Query: 985 PLGFEGQRCEINPDDCEDNDCENNATC-VDGINNY-VCICPPNYTGELCDEVIDHCVPEL 1042
P+G G C ++ D C N C +A C + +N +C CPP +TG CD+ +D C
Sbjct: 341 PMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGA 399
Query: 1043 NLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQ 1102
N C+H +C+ F C+C GY+G CETD ++C++ CR+ A C+D I +TC C
Sbjct: 400 NPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459
Query: 1103 GFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
GF+G +CE + C C NG C +C CP GF+G C+
Sbjct: 460 GFTGTYCE-------VDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
Score = 171 bits (434), Expect = 4e-42
Identities = 82/244 (33%), Positives = 121/244 (49%), Gaps = 15/244 (6%)
Query: 920 CLSSPCKNNGTCTQDPVE---LYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSH 976
C S PC G C V + C CP ++G DC++P + C+ +PC HG C +
Sbjct: 82 CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDG 140
Query: 977 KDGFSCSCPLGFEGQRCEINPDDCEDND-CENNATCVDGINNYVCICPPNYTGELCDEVI 1035
+ F CSCP G++G+ C + D+C + C + TC++ ++ C CP YTG LC+
Sbjct: 141 R--FLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPA 198
Query: 1036 DHCVPELNLCQHEAKCIPL-DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN 1094
C P + C++ C D + C C+PG+ G+ CE + DDC H+C +G CVD +N
Sbjct: 199 VPCAP--SPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 256
Query: 1095 GYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
Y C CP ++G FC LQ + C NG C +C C G+ G C
Sbjct: 257 TYNCQCPPEWTGQFCTEDVDECQLQPNAC-----HNGGTCFNTLGGHSCVCVNGWTGESC 311
Query: 1155 EKLI 1158
+ I
Sbjct: 312 SQNI 315
Score = 167 bits (424), Expect = 5e-41
Identities = 83/278 (29%), Positives = 121/278 (43%), Gaps = 49/278 (17%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSH- 976
+AC S PC+ GTC+ D + + C CP +G+ C + ++ C NPC+HGG C +
Sbjct: 736 DACESQPCRAGGTCSSDGMG-FHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQL 793
Query: 977 ------------------------------------KDGFSCSCPLGFEGQRCEINPDDC 1000
FSC+C G+ G C+ + +DC
Sbjct: 794 PVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC 853
Query: 1001 EDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSC 1060
+ N C N +C DG+ ++ C C P + G C +D C+ N C C F+C
Sbjct: 854 DPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLS--NPCG-PGTCTDHVASFTC 910
Query: 1061 ECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQT 1120
C PGY G CE D DC C +G CVD +N ++C C G++G C+H +
Sbjct: 911 TCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQH-------EA 963
Query: 1121 SPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
PC C +G C C C F GP+C+ L+
Sbjct: 964 DPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLV 1001
Score = 167 bits (422), Expect = 9e-41
Identities = 86/238 (36%), Positives = 108/238 (45%), Gaps = 14/238 (5%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C PC ++G C D + + CAC Y G C ++ C PC+HGG C D
Sbjct: 549 CSPDPC-HHGRCV-DGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCL---DLVDK 603
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
+ C CP G G CE+N DDC N C C DGIN Y C+C P +TG LC+ I+ C
Sbjct: 604 YLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECA 662
Query: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCT 1099
+ C C+ + GF C C PG LC + C C HG C D G+ C
Sbjct: 663 S--SPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCV 719
Query: 1100 CPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKL 1157
C G+SGP C L C+ C+ G C C CPPG G +CE L
Sbjct: 720 CEPGWSGPRCSQS-----LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL 772
Score = 150 bits (379), Expect = 9e-36
Identities = 92/292 (31%), Positives = 116/292 (39%), Gaps = 62/292 (21%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
CL+ PC++ GTC + + Y C C Y G +C ++ C PCQHGG+C +
Sbjct: 1088 CLAQPCQHGGTC-RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR--- 1143
Query: 980 FSCSCPLGFEGQRCEINPDDCEDND-------CENNATCVDGINNYVCICPPNYTGELCD 1032
+ CSCP G G CEIN DDC C +N TCVD + + C CPP YTG C+
Sbjct: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Query: 1033 EVIDHCVPELNLCQHEAKCIP-LDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQC-- 1089
I+ C H C+ GF C C G+SG C+T C + C+HG QC
Sbjct: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRP 1263
Query: 1090 -----------------------------------------VDTINGYTCTCPQGFSGPF 1108
T G C CP G SGP
Sbjct: 1264 SPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPS 1323
Query: 1109 CEH---PPPMVLLQTSPCDQYECQNGAQCIVVQQEP--TCRCPPGFAGPRCE 1155
C PP + C C +G C P C C G+ GPRCE
Sbjct: 1324 CRSFPGSPPGA--SNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
Score = 138 bits (347), Expect = 5e-32
Identities = 85/301 (28%), Positives = 119/301 (39%), Gaps = 48/301 (15%)
Query: 890 MADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKG 949
+ D+ L P+ G +N + C S+PC G C +D + Y C C + G
Sbjct: 600 LVDKYLCRCPS------GTTGVNCEVNIDDCASNPC-TFGVC-RDGINRYDCVCQPGFTG 651
Query: 950 KDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNA 1009
C V IN C +PC GG+C ++GF C CP G C C C ++
Sbjct: 652 PLCNVEINECASSPCGEGGSCV---DGENGFRCLCPPGSLPPLCLPPSHPCAHEPC-SHG 707
Query: 1010 TCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGK 1069
C D + C+C P ++G C + + E C+ C GF C C PG G+
Sbjct: 708 ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGR 767
Query: 1070 LCETDNDDCVAHKCRHGAQCVDTINGY--TCTCPQGFSGPFCE----------------- 1110
CE C + C HG +C ++ G C+CPQG+ GP C+
Sbjct: 768 QCEL-LSPCTPNPCEHGGRC-ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI 825
Query: 1111 ---------------HPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
+ P + CD C NG C +C C PGFAGPRC
Sbjct: 826 CTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCA 885
Query: 1156 K 1156
+
Sbjct: 886 R 886
Score = 128 bits (322), Expect = 4e-29
Identities = 137/557 (24%), Positives = 211/557 (37%), Gaps = 98/557 (17%)
Query: 997 PDDCEDNDCENNATCVD-GINNYVCICPPNYTGELCD-EVIDHCVPELNLCQHEAKCIPL 1054
P + + C N C C+CPP + GE C E H P ++ +
Sbjct: 41 PPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG 100
Query: 1055 DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING-YTCTCPQGFSGPFCEHPP 1113
FSC C G+ G C D C++ C HGA+C +G + C+CP G+ G C
Sbjct: 101 TARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS-- 157
Query: 1114 PMVLLQTSPCDQYE-CQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELA 1172
C E C++G C+ C+CP G+ GP CE + V A
Sbjct: 158 -----DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE----------NPAVPCA 202
Query: 1173 SAKVRPQANISLQVATDKDNGILLY--------KGDNDPLALELYQGHVRLVYDSLSSPP 1224
+ R T + +G L Y +G N + ++ GH L +
Sbjct: 203 PSPCR-------NGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCL------NGG 249
Query: 1225 TTVYSVETVN-------DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPL 1277
T V V T N GQF + ++ N + GT L V +N
Sbjct: 250 TCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGT--CFNTLGGHSCVCVNG-- 305
Query: 1278 YLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQS-----LGVSPGC 1332
TG S + D C H ++ + F P + C
Sbjct: 306 -------WTGESCSQNIDDCATAV---CFHGATCHDRVASFYCACPMGKTGLLCHLDDAC 355
Query: 1333 KSCTVCKHGLCRSVEKDS-VVCECRPGWTGPLCDQEARDPCLG-HRCHH-GKCVATGTSY 1389
S + +C + + +C C PG+TG CDQ+ + +G + C H G+CV T S+
Sbjct: 356 VSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSF 415
Query: 1390 MCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ----- 1444
+C+C GY G C+ N C + C + + G+ C+C GF+G +C+
Sbjct: 416 LCQCGRGYTGPRCET---DVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDE 472
Query: 1445 -QENPCL-GQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCT 1502
Q +PC+ G V ++ R G+ SC C G CQ + C
Sbjct: 473 CQSSPCVNGGVCKD---RVNGF-SCT---------CPSGFSGSTCQLDVDECAS--TPCR 517
Query: 1503 DGSSFVEEVERHLECGC 1519
+G+ V++ + + EC C
Sbjct: 518 NGAKCVDQPDGY-ECRC 533
Score = 115 bits (287), Expect = 4e-25
Identities = 71/221 (32%), Positives = 86/221 (38%), Gaps = 19/221 (8%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSC 984
C +NGTC D V +RC CP Y G C IN C C T GF C C
Sbjct: 1176 CLHNGTCV-DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLC 1234
Query: 985 PLGFEGQRCEINPDDCEDNDCENNATC-----VDGINNYVCICPPNYTGELCDEVIDHCV 1039
GF G RC+ CE C++ C G + C C + G C+ V C
Sbjct: 1235 HAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSC- 1293
Query: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCET--------DNDDCVAHKCRHGAQC-- 1089
EL C C +G C C PG SG C + N C A C HG C
Sbjct: 1294 RELQ-CPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
Query: 1090 VDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSP-CDQYECQ 1129
+ C C QG++GP CE P + P C + CQ
Sbjct: 1353 APLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQ 1393
Score = 80.9 bits (198), Expect = 9e-15
Identities = 52/160 (32%), Positives = 70/160 (43%), Gaps = 18/160 (11%)
Query: 1336 TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAE 1395
T C++G + D C C G+ G LCD+ D C CHHG+CV S+ C CA
Sbjct: 514 TPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNV-DDCSPDPCHHGRCVDGIASFSCACAP 572
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPC 1449
GY G C+++ D C + C HG + + C C G +G +C+ NPC
Sbjct: 573 GYTGTRCESQVDE---CRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC 629
Query: 1450 LGQVVREVIRR-----QKGYASCATASKVPIMECRGG-CG 1483
V R+ I R Q G+ V I EC CG
Sbjct: 630 TFGVCRDGINRYDCVCQPGFT--GPLCNVEINECASSPCG 667
Score = 80.1 bits (196), Expect = 2e-14
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 5/104 (4%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSA 1409
S C C PG+ GP C ++ D CL + C G C S+ C C GYGG C+
Sbjct: 870 SFSCSCLPGFAGPRCARDV-DECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPD- 927
Query: 1410 NACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQ 1452
CS C +G + CLC+PG++G HCQ E +PCL +
Sbjct: 928 --CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSR 969
Score = 79.7 bits (195), Expect = 2e-14
Identities = 48/140 (34%), Positives = 63/140 (45%), Gaps = 6/140 (4%)
Query: 1312 NNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDP 1371
+ L D ++LP + G + +C+ G E S C C G TG C+QE DP
Sbjct: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV-DP 1087
Query: 1372 CLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEP 1430
CL C H G C YMC+C GY GD C+ D + C++ C HG I
Sbjct: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE---DDVDECASQPCQHGGSCIDLVARY 1144
Query: 1431 YCLCQPGFSGEHCQ-QENPC 1449
C C PG G C+ E+ C
Sbjct: 1145 LCSCPPGTLGVLCEINEDDC 1164
Score = 72.8 bits (177), Expect = 2e-12
Identities = 44/121 (36%), Positives = 51/121 (42%), Gaps = 13/121 (10%)
Query: 1338 CKHG-LCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-C-HHGKCVATGTSYMCKCA 1394
C+HG C S VC C GW GP C Q+ D C G C HG C S+ C C
Sbjct: 780 CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDV-DECAGPAPCGPHGICTNLAGSFSCTCH 838
Query: 1395 EGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE------NP 1448
GY G CD N C C +G G C C PGF+G C ++ NP
Sbjct: 839 GGYTGPSCD---QDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895
Query: 1449 C 1449
C
Sbjct: 896 C 896
Score = 71.2 bits (173), Expect = 7e-12
Identities = 64/237 (27%), Positives = 85/237 (35%), Gaps = 61/237 (25%)
Query: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG--------- 1380
P C + G C +S C CRPG+TG C EA DPCL C HG
Sbjct: 926 PDCSPSSCFNGGTCVD-GVNSFSCLCRPGYTGAHCQHEA-DPCLSRPCLHGGVCSAAHPG 983
Query: 1381 ------------------------------KCVATGTSYMCKCAEGYGGDLCDNKNDSAN 1410
+CV TG C C G+ G LCD ++
Sbjct: 984 FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA--YCLCPPGWSGRLCDIRSLPCR 1041
Query: 1411 ACSAF-------KCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQVVREVIRRQK 1462
+A C G + + YC+C G +G HC+QE +PCL Q Q
Sbjct: 1042 EAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPC------QH 1095
Query: 1463 GYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
G +C + EC G C+ + C G S ++ V R+L C C
Sbjct: 1096 G-GTCRGYMGGYMCECLPGYNGDNCEDDVDECASQ--PCQHGGSCIDLVARYL-CSC 1148
Score = 68.2 bits (165), Expect = 6e-11
Identities = 60/223 (26%), Positives = 86/223 (38%), Gaps = 43/223 (19%)
Query: 1319 KALPPQSLGVSPG-----CKSCTVCKHG-LCRSVEKDSVVCECRPGWTGPLCDQEARDPC 1372
+ALP L PG C + C +G C + C C PGW G C E DPC
Sbjct: 25 RALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE--DPC 82
Query: 1373 LGHRCH-HGKC---VATGTS-YMCKCAEGYGGDLCDNKNDSANACSAFKCHHG-QCHISD 1426
C G C V GT+ + C+C G+ G C + C + C HG +C +
Sbjct: 83 HSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS----LPDPCLSSPCAHGARCSVGP 138
Query: 1427 QGEPYCLCQPGFSGEHCQQE-NPC-LGQVVREVIRRQKGYASCATASKVPIMECRGG-CG 1483
G C C PG+ G C+ + + C +G+ R +C +C G G
Sbjct: 139 DGRFLCSCPPGYQGRSCRSDVDECRVGEPCRH-------GGTCLNTPGSFRCQCPAGYTG 191
Query: 1484 PQC------CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCL 1520
P C C P+ C +G + + + +C CL
Sbjct: 192 PLCENPAVPCAPS---------PCRNGGTCRQSGDLTYDCACL 225
Score = 68.2 bits (165), Expect = 6e-11
Identities = 47/189 (24%), Positives = 71/189 (37%), Gaps = 46/189 (24%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARD--------------------------- 1370
C G+CR + C C+PG+TGPLC+ E +
Sbjct: 629 CTFGVCRD-GINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGS 687
Query: 1371 ----------PCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHG 1420
PC C HG C + C C G+ G C +++ + +AC + C G
Sbjct: 688 LPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRC-SQSLARDACESQPCRAG 746
Query: 1421 QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMEC-R 1479
SD +C C PG G C+ +PC + G + ++P+ C +
Sbjct: 747 GTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPC------EHGGRCESAPGQLPVCSCPQ 800
Query: 1480 GGCGPQCCQ 1488
G GP+C Q
Sbjct: 801 GWQGPRCQQ 809
Score = 65.9 bits (159), Expect = 3e-10
Identities = 49/180 (27%), Positives = 70/180 (38%), Gaps = 27/180 (15%)
Query: 1338 CKHG-LCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAE 1395
C+HG CR +CEC PG+ G C+ + D C C H G C+ Y+C C
Sbjct: 1093 CQHGGTCRGY-MGGYMCECLPGYNGDNCEDDV-DECASQPCQHGGSCIDLVARYLCSCPP 1150
Query: 1396 GYGGDLCDNKNDSAN----ACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------Q 1445
G G LC+ D S +C H + G C C PG++G C+ +
Sbjct: 1151 GTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECR 1210
Query: 1446 ENPCLGQVVREVIRRQKGYASCATASKVPIMECRGG-CGPQC---CQPTRSKRRKYVFQC 1501
C R+ ++ G C C G GP+C P S+ ++ QC
Sbjct: 1211 SGACHAAHTRDCLQDPGGGFRCL---------CHAGFSGPRCQTVLSPCESQPCQHGGQC 1261
Score = 63.5 bits (153), Expect = 1e-09
Identities = 58/219 (26%), Positives = 84/219 (38%), Gaps = 31/219 (14%)
Query: 1294 GTDRPLGGFHGCIHEVRINNELQDFKAL-PPQSLGVSPGCKS-CTVCKHGLCRSVEKDSV 1351
G PL C+H + + F+ PP G+ C++ C+ G C +
Sbjct: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR--CEADINECRSGACHAAHTRDC 1222
Query: 1352 V--------CECRPGWTGPLCDQEARDPCLGHRCHHG-KCVAT-----GTSYMCKCAEGY 1397
+ C C G++GP C Q PC C HG +C + G ++ C CA+ +
Sbjct: 1223 LQDPGGGFRCLCHAGFSGPRC-QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF 1281
Query: 1398 GGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPYCLCQPGFSGEHCQQ---ENPCLGQV 1453
G C+ A +C +C G C + +G P C C PG SG C+ P
Sbjct: 1282 WGPRCERV---ARSCRELQCPVGVPCQQTPRG-PRCACPPGLSGPSCRSFPGSPPGASNA 1337
Query: 1454 VREVIRRQKGYASCATASKVPIMEC---RGGCGPQCCQP 1489
G SC A P C +G GP+C P
Sbjct: 1338 SCAAAPCLHG-GSCRPAPLAPFFRCACAQGWTGPRCEAP 1375
Score = 55.1 bits (131), Expect = 5e-07
Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 8/109 (7%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEG 1396
C G C S C C PG+ G C+Q+ D C C + G CV S+ C C G
Sbjct: 896 CGPGTCTD-HVASFTCTCPPGYGGFHCEQDLPD-CSPSSCFNGGTCVDGVNSFSCLCRPG 953
Query: 1397 YGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
Y G C ++ A+ C + C H G C + G C C F+G CQ
Sbjct: 954 YTGAHCQHE---ADPCLSRPCLHGGVCSAAHPGF-RCTCLESFTGPQCQ 998
Score = 52.8 bits (125), Expect = 3e-06
Identities = 66/262 (25%), Positives = 93/262 (35%), Gaps = 33/262 (12%)
Query: 1283 PTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKS-CTVCKHG 1341
P TG A Q D G + C H R N F + P C++ C G
Sbjct: 381 PGFTG-GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY-TGPRCETDVNECLSG 438
Query: 1342 LCRSVEK-----DSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAE 1395
CR+ C C G+TG C+ + D C C + G C + C C
Sbjct: 439 PCRNQATCLDRIGQFTCICMAGFTGTYCEVDI-DECQSSPCVNGGVCKDRVNGFSCTCPS 497
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQE------NP 1448
G+ G C D C++ C +G + DQ + Y C C GF G C + +P
Sbjct: 498 GFSGSTCQLDVDE---CASTPCRNGAKCV-DQPDGYECRCAEGFEGTLCDRNVDDCSPDP 553
Query: 1449 C-LGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRR------KYVFQC 1501
C G+ V + SCA A C QP R + KY+ +C
Sbjct: 554 CHHGRCVDGI-----ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC 608
Query: 1502 TDGSSFVEEVERHLECGCLACS 1523
G++ V +C C+
Sbjct: 609 PSGTTGVNCEVNIDDCASNPCT 630
Score = 49.7 bits (117), Expect = 2e-05
Identities = 62/272 (22%), Positives = 77/272 (28%), Gaps = 94/272 (34%)
Query: 903 FQCKGP---VDINIVAKCNACLSSPCKNNGT--CTQDPVELYRCACPYSYKGKDCTVPIN 957
F+C P + A N C S C T C QDP +RC C + G C ++
Sbjct: 1189 FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLS 1248
Query: 958 TCIQNPCQHGGTCHLSDSHKDGFS------------------------------------ 981
C PCQHGG C S G +
Sbjct: 1249 PCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTP 1308
Query: 982 ----CSCPLGFEGQRCEINPDD--------CEDNDCENNATCVDG--INNYVCICPPNYT 1027
C+CP G G C P C C + +C + C C +T
Sbjct: 1309 RGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWT 1368
Query: 1028 GELCD------EVIDH----------------CVPELNL--CQHEAKCIPLDKGF---SC 1060
G C+ EV + C E N C + L G C
Sbjct: 1369 GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQC 1428
Query: 1061 E------------CVPGYSGKLCETDNDDCVA 1080
E C P S C DN DC A
Sbjct: 1429 EALQCWRLFNNSRCDPACSSPACLYDNFDCHA 1460
Score = 41.2 bits (95), Expect = 0.008
Identities = 49/188 (26%), Positives = 68/188 (36%), Gaps = 27/188 (14%)
Query: 1319 KALPPQSLGVSPGCKSCTVCKHG-LCRSVEKDSVV-CECRPGWTGPLCDQEARDPCLGH- 1375
++ P G S + C HG CR C C GWTGP C+ A P +
Sbjct: 1325 RSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEE 1384
Query: 1376 -RCHHGKCVATGTSYMC--KCAE---GY-GGDLCDNKNDSANACSAFKC----HHGQCHI 1424
RC C A C +C G+ GGD + D C A +C ++ +C
Sbjct: 1385 PRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDP 1444
Query: 1425 SDQGEPYCL-----CQPGFSGEHCQ--QENPCL-----GQVVREVIRRQKGYASCATASK 1472
+ P CL C G C E C G+ + + G+ AS+
Sbjct: 1445 A-CSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASE 1503
Query: 1473 VPIMECRG 1480
VP + RG
Sbjct: 1504 VPALLARG 1511
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 202 bits (513), Expect = 3e-51
Identities = 105/304 (34%), Positives = 139/304 (45%), Gaps = 30/304 (9%)
Query: 856 TNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVD---IN 912
T P C CS W + PG S EP +QC + +
Sbjct: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP-------------WQCNCETNWGGLL 303
Query: 913 IVAKCNACLSS-PCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH 971
N C S PC N GTC + YRC CP Y G++C + C NPC +GG+CH
Sbjct: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363
Query: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
S GF C CP G+ G C ++ D+C N C TCVD ++ + CICP + G C
Sbjct: 364 EVPS---GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
Query: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
+ C E C + C L G+ C+C+PG+ G C + +DC +C+HG C D
Sbjct: 421 QLDANEC--EGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRG-QCQHGGTCKD 477
Query: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
+NGY C CP+GF G CE L+ C C +G C + C CP GF+G
Sbjct: 478 LVNGYQCVCPRGFGGRHCE-------LERDECASSPCHSGGLCEDLADGFHCHCPQGFSG 530
Query: 1152 PRCE 1155
P CE
Sbjct: 531 PLCE 534
Score = 176 bits (445), Expect = 2e-43
Identities = 85/240 (35%), Positives = 119/240 (49%), Gaps = 14/240 (5%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
CL PC+N GTC D V+ +RC CP ++G+ C N C+ +PC G C+ D D
Sbjct: 640 CLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY--DLVND- 695
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH-C 1038
F C+C G++G+ C C+ C N TC D + + C CPP + G C + C
Sbjct: 696 FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC 755
Query: 1039 VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
+P N C + C+ FSC C G+ G+ C + +DC C +G CVD +N + C
Sbjct: 756 LP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
Query: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
C GF+GP C + C C GA C+ C CPPG AGPRC+++I
Sbjct: 814 ECAPGFAGPDCR-------INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
Score = 166 bits (421), Expect = 1e-40
Identities = 90/297 (30%), Positives = 125/297 (42%), Gaps = 58/297 (19%)
Query: 911 INIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTC 970
IN N C C++ GTC +D V Y+C CP + G+ C + + C +PC GG C
Sbjct: 456 INCHINVNDCRGQ-CQHGGTC-KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC 513
Query: 971 HLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL 1030
+ DGF C CP GF G CE++ D CE + C N A C + +Y C CP ++ G+
Sbjct: 514 ---EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKN 570
Query: 1031 CD-----------EVIDHCVPEL----------NLCQHEAKCIPLDKG-FSCECVPGYSG 1068
C VID C + +C +C+ G FSC C G++G
Sbjct: 571 CSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG 630
Query: 1069 KLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVL----------- 1117
C + DDC+ CR+G C+D ++ + C CP G+ G C+ P L
Sbjct: 631 TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY 690
Query: 1118 --------------------LQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
+ CD Y C NG C C CPPG+ G C
Sbjct: 691 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
Score = 153 bits (386), Expect = 1e-36
Identities = 91/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD----- 974
C SPC+N C + Y CACP + GK+C+VP + PC GG C + D
Sbjct: 540 CEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVP-----REPCP-GGACRVIDGCGSD 592
Query: 975 ---------------------SHKDG-FSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012
S G FSC C GF G C N DDC C N TC+
Sbjct: 593 AGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI 652
Query: 1013 DGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
D ++ + C CP + GELCD + C+P+ C +C L F C C G+ GK C
Sbjct: 653 DEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCH 710
Query: 1073 TDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE-------HPPPMV--------- 1116
+ C A+ C +G C D+ + + C CP G+ G C P P V
Sbjct: 711 SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG 770
Query: 1117 ----------------LLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
T+ C+ C NG C+ C C PGFAGP C
Sbjct: 771 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 824
Score = 149 bits (376), Expect = 2e-35
Identities = 87/296 (29%), Positives = 120/296 (40%), Gaps = 52/296 (17%)
Query: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADR-LLLTTPTHRFQCKGPVDI---NI 913
P C+C W + + C S P + + +++C P N
Sbjct: 290 PWQCNCETNWGGLLC-----DKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
+AC S+PC N G+C + P + C CP + G C + I+ C NPC GGTC
Sbjct: 345 EKAEHACTSNPCANGGSCHEVPSG-FECHCPSGWSGPTCALDIDECASNPCAAGGTCV-- 401
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCED------------------------------- 1002
DGF C CP + G C+++ ++CE
Sbjct: 402 -DQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
Query: 1003 --NDC----ENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDK 1056
NDC ++ TC D +N Y C+CP + G C+ D C + C C L
Sbjct: 461 NVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS--SPCHSGGLCEDLAD 518
Query: 1057 GFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHP 1112
GF C C G+SG LCE D D C CR+GA+C + Y C CP F G C P
Sbjct: 519 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP 574
Score = 149 bits (375), Expect = 3e-35
Identities = 74/194 (38%), Positives = 99/194 (51%), Gaps = 7/194 (3%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N CL PC + G C D V + CAC +KGK C C C +GGTC+ S
Sbjct: 676 NDCLPDPCHSRGRC-YDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG--- 731
Query: 978 DGFSCSCPLGFEGQRCEINPDD-CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
D F C+CP G++G C + + C N C N TCV ++ CIC + G C +
Sbjct: 732 DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN 791
Query: 1037 HCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
C P C + C+ F CEC PG++G C + D+C + C +GA CVD INGY
Sbjct: 792 DCNPLP--CYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849
Query: 1097 TCTCPQGFSGPFCE 1110
C+CP G +GP C+
Sbjct: 850 RCSCPPGRAGPRCQ 863
Score = 108 bits (270), Expect = 4e-23
Identities = 54/125 (43%), Positives = 65/125 (52%), Gaps = 10/125 (8%)
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
VAK ++CL +PC N GTC + C C ++G+ CT N C PC +GG C
Sbjct: 749 VAKNSSCLPNPCVNGGTCVGSGAS-FSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC--- 804
Query: 974 DSHKDG---FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL 1030
DG F C C GF G C IN D+C+ + C ATCVD IN Y C CPP G
Sbjct: 805 ---VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 861
Query: 1031 CDEVI 1035
C EVI
Sbjct: 862 CQEVI 866
Score = 73.6 bits (179), Expect = 1e-12
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C + T G C D+ C C PGW G C CL + C + G CV +G S+
Sbjct: 716 CDAYTCSNGGTCYD-SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 774
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------ 1444
C C +G+ G C + + N C+ C++G + C C PGF+G C+
Sbjct: 775 CICRDGWEGRTCTH---NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 831
Query: 1445 QENPC 1449
Q +PC
Sbjct: 832 QSSPC 836
Score = 67.8 bits (164), Expect = 8e-11
Identities = 40/123 (32%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH-HGKCVATGTSYMCKCAEG 1396
C++G E D+ C C GW G LCD D CL CH G+C + C C +G
Sbjct: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND-CLPDPCHSRGRCYDLVNDFYCACDDG 703
Query: 1397 YGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPY-CLCQPGFSGEHCQ-------QEN 1447
+ G C ++ C A+ C + G C+ D G+ + C C PG+ G C N
Sbjct: 704 WKGKTCHSREFQ---CDAYTCSNGGTCY--DSGDTFRCACPPGWKGSTCAVAKNSSCLPN 758
Query: 1448 PCL 1450
PC+
Sbjct: 759 PCV 761
Score = 63.2 bits (152), Expect = 2e-09
Identities = 60/203 (29%), Positives = 79/203 (38%), Gaps = 46/203 (22%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVV---CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS 1388
CK VCK G C + V C C GW G CD+ P C HG CV
Sbjct: 240 CKEA-VCKQG-CNLLHGGCTVPGECRCSYGWQGRFCDECVPYP----GCVHGSCV---EP 290
Query: 1389 YMCKCAEGYGGDLCDNKNDSANAC-SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQ- 1445
+ C C +GG LCD N C S C +G I+ + + Y C C G+SG +C++
Sbjct: 291 WQCNCETNWGGLLCDK---DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347
Query: 1446 -----ENPCLGQVVREVIRRQKGYASCATASKVPI-MECR---GGCGPQCCQPTRSKRRK 1496
NPC A+ + +VP EC G GP C
Sbjct: 348 EHACTSNPC---------------ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
Query: 1497 YVFQCTDGSSFVEEVERHLECGC 1519
C G + V++V+ EC C
Sbjct: 393 ---PCAAGGTCVDQVD-GFECIC 411
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 10/103 (9%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANAC 1412
C+C PGW G C D C G H G C Y C C G+GG C+ + D C
Sbjct: 447 CDCIPGWKGINCHINVND-CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE---C 502
Query: 1413 SAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPC 1449
++ CH G +C C GFSG C+ + +PC
Sbjct: 503 ASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 545
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/147 (27%), Positives = 57/147 (38%), Gaps = 25/147 (17%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
C S GLC + D C C G++GPLC+ + D C C +G +C Y
Sbjct: 502 CASSPCHSGGLCEDLA-DGFHCHCPQGFSGPLCEVDV-DLCEPSPCRNGARCYNLEGDYY 559
Query: 1391 CKCAEGYGGDLCDNKNDSA---------------------NACSAFKCHHGQCHISDQGE 1429
C C + +GG C + A S HG+C G
Sbjct: 560 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 619
Query: 1430 PYCLCQPGFSGEHCQQE-NPCLGQVVR 1455
C+C GF+G +C + + CLGQ R
Sbjct: 620 FSCICDSGFTGTYCHENIDDCLGQPCR 646
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 28/157 (17%)
Query: 1003 NDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCEC 1062
ND + TC D N C+ + G+ C E + C NL H +P + C C
Sbjct: 215 NDFFGHYTC-DQYGNKACM--DGWMGKECKEAV--CKQGCNLL-HGGCTVPGE----CRC 264
Query: 1063 VPGYSGKLCETDNDDCVAHK-CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTS 1121
G+ G+ C D+CV + C HG+ CV+ + C C + G C+ +
Sbjct: 265 SYGWQGRFC----DECVPYPGCVHGS-CVEP---WQCNCETNWGGLLCDK-------DLN 309
Query: 1122 PCDQYE-CQNGAQCIVVQQEP-TCRCPPGFAGPRCEK 1156
C + C NG CI + + C CP G++G CEK
Sbjct: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
Score = 56.6 bits (135), Expect = 2e-07
Identities = 47/165 (28%), Positives = 59/165 (35%), Gaps = 20/165 (12%)
Query: 1300 GGFHGCIHE-VRINNELQDFKALPPQSLG------VSPGCKSCTVCKHGLCRSVEKDSVV 1352
G H C + IN E ++ P C S G C V
Sbjct: 312 GSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPS-GFE 370
Query: 1353 CECRPGWTGPLC----DQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
C C GW+GP C D+ A +PC G CV + C C E + G C
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAG----GTCVDQVDGFECICPEQWVGATCQL---D 423
Query: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLGQ 1452
AN C C + + G YC C PG+ G +C N C GQ
Sbjct: 424 ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ 468
Score = 48.1 bits (113), Expect = 6e-05
Identities = 38/140 (27%), Positives = 52/140 (37%), Gaps = 32/140 (22%)
Query: 1338 CKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH------------------ 1378
C++G C ++E D C C + G C R+PC G C
Sbjct: 545 CRNGARCYNLEGD-YYCACPDDFGGKNCSVP-REPCPGGACRVIDGCGSDAGPGMPGTAA 602
Query: 1379 ------HGKCVAT-GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY 1431
HG+CV+ G ++ C C G+ G C D C C +G I +
Sbjct: 603 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD---CLGQPCRNGGTCIDEVDAFR 659
Query: 1432 CLCQPGFSGEHCQ-QENPCL 1450
C C G+ GE C N CL
Sbjct: 660 CFCPSGWEGELCDTNPNDCL 679
Score = 32.7 bits (73), Expect = 2.8
Identities = 42/177 (23%), Positives = 62/177 (35%), Gaps = 27/177 (15%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C+S + C +G E + C C PG GP C + G C G G+S++
Sbjct: 831 CQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---FGRSCWSRGTPFPHGSSWV 886
Query: 1391 -----CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
C+C +G CS C C ++ G+P L G+ C +
Sbjct: 887 EDCNSCRCLDG------------RRDCSKVWCGWKPCLLA--GQPEALSAQCPLGQRCLE 932
Query: 1446 ENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCT 1502
+ P GQ +R G P + G C + T R +V Q T
Sbjct: 933 KAP--GQCLRPPCEAW-GECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGT 986
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 196 bits (498), Expect = 1e-49
Identities = 101/304 (33%), Positives = 146/304 (48%), Gaps = 23/304 (7%)
Query: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADR-LLLTTPTHRFQCKGPVDI---NI 913
P C C W + + + C + +P + T ++QC P N
Sbjct: 279 PWQCLCETNWGGQLC-----DKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNC 333
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
+ACLS PC N G+C + + + C C + G C+ I+ C N C HGGTC
Sbjct: 334 EIAEHACLSDPCHNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ-- 390
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDE 1033
+GF C CP + G+ C+++ ++CE C N +C + I +Y C C P + G+ CD
Sbjct: 391 -DLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449
Query: 1034 VIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTI 1093
I+ C L CQ++A C L G+ C C PGY+G CE D D+C ++ C +G C + I
Sbjct: 450 NINDC---LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEI 506
Query: 1094 NGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
N + C CP GFSG C+ L C+ CQNGAQC + C+CP + G
Sbjct: 507 NRFQCLCPTGFSGNLCQ-------LDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKN 559
Query: 1154 CEKL 1157
C L
Sbjct: 560 CSHL 563
Score = 178 bits (452), Expect = 3e-44
Identities = 85/241 (35%), Positives = 121/241 (50%), Gaps = 14/241 (5%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S+PC+N GTC D V Y+C C ++G C IN C QNPC +GGTC D
Sbjct: 631 NDCESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCR--DLVN 687
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
D F C C G++G+ C C++ C N TC D + + C+CP + G C+ +
Sbjct: 688 D-FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNS 746
Query: 1038 -CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
C+P N C + C+ + F+C C G+ G +C + +DC H C + CVD N Y
Sbjct: 747 SCLP--NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
Query: 1097 TCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
C C GF+GP C + + C C GA C+ C CPPG +G +C++
Sbjct: 805 RCECAPGFAGPDCR-------ININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQE 857
Query: 1157 L 1157
+
Sbjct: 858 V 858
Score = 164 bits (415), Expect = 6e-40
Identities = 86/282 (30%), Positives = 123/282 (43%), Gaps = 37/282 (13%)
Query: 901 HRFQCKGPVDIN---IVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPIN 957
+RFQC P + + C +PC+N C + Y C CP Y+GK+C+ +
Sbjct: 507 NRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD-YFCKCPEDYEGKNCSHLKD 565
Query: 958 TCIQNPCQHGGTCHLSDSHKDG-------------------------FSCSCPLGFEGQR 992
C PC+ +C ++ + D F+C C GF G
Sbjct: 566 HCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTY 625
Query: 993 CEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCI 1052
C N +DCE N C N TC+DG+N+Y CIC + G C+ I+ C N C + C
Sbjct: 626 CHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDC--SQNPCHNGGTCR 683
Query: 1053 PLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHP 1112
L F C+C G+ GK C + + C C +G C D + + C CP G+ G C
Sbjct: 684 DLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCN-- 741
Query: 1113 PPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
+ + S C C NG C+V + TC C G+ GP C
Sbjct: 742 ----IARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
Score = 159 bits (402), Expect = 2e-38
Identities = 99/324 (30%), Positives = 140/324 (43%), Gaps = 54/324 (16%)
Query: 879 PGIARCSSPE-------PMADRLLLTTPTH-RFQCKGPVDINIVAKCNA----------- 919
P +CS PE +A+ L+ P H R CK + +C+
Sbjct: 317 PDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK-ETSLGFECECSPGWTGPTCSTNI 375
Query: 920 --CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
C + C + GTC QD V ++C CP + GK C + N C PC + +C +
Sbjct: 376 DDCSPNNCSHGGTC-QDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIA-- 432
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
+ C C G+ GQ C+IN +DC C+N+A+C D +N Y CICPP Y G+ C+ ID
Sbjct: 433 -SYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C N C + C F C C G+SG LC+ D D C + C++GAQC + + Y
Sbjct: 491 CAS--NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEP---------------- 1141
C CP+ + G C H +T+PC+ + A E
Sbjct: 549 CKCPEDYEGKNCSHLKDHC--RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCK 606
Query: 1142 -------TCRCPPGFAGPRCEKLI 1158
TC C GF G C + I
Sbjct: 607 SQSGGKFTCDCNKGFTGTYCHENI 630
Score = 80.5 bits (197), Expect = 1e-14
Identities = 51/176 (28%), Positives = 74/176 (42%), Gaps = 15/176 (8%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEG 1396
C +G V +S C C+ GW GP+C Q D C H C++ G CV Y C+CA G
Sbjct: 753 CHNGGTCVVNGESFTCVCKEGWEGPICAQNTND-CSPHPCYNSGTCVDGDNWYRCECAPG 811
Query: 1397 YGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQEN--PC--LGQ 1452
+ G C + N C + C G + + C+C PG SG CQ+ + PC +G
Sbjct: 812 FAGPDC---RININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGS 868
Query: 1453 VVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFV 1508
V+ + + +C + R C C P K +C G S +
Sbjct: 869 VIPDGAKWDDDCNTC------QCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCI 918
Score = 74.3 bits (181), Expect = 8e-13
Identities = 49/175 (28%), Positives = 72/175 (41%), Gaps = 25/175 (14%)
Query: 983 SCPLGFEGQRCEINPDDCEDNDCENNATC-VDGINNYVCICPPNYTGELCDEVIDHCVPE 1041
+C G+ G C N C + +C + G C C + G CD+ I H
Sbjct: 219 TCMEGWMGPEC--NRAICRQGCSPKHGSCKLPGD----CRCQYGWQGLYCDKCIPHPGCV 272
Query: 1042 LNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHK-CRHGAQCVDT-INGYTCT 1099
+C +C+ C + G+LC+ D + C H+ C +G C +T + Y C+
Sbjct: 273 HGICNEPWQCL---------CETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323
Query: 1100 CPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRC 1154
CP+G+SGP CE + C C N C C C PG+ GP C
Sbjct: 324 CPEGYSGPNCE-------IAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
Score = 70.5 bits (171), Expect = 1e-11
Identities = 50/163 (30%), Positives = 68/163 (41%), Gaps = 25/163 (15%)
Query: 1303 HGCIHEVRINNELQDFKAL-PPQSLGVSPGCKSCTV----CKHGLCRSVEK-----DSVV 1352
+ C H + + FK + PPQ G K+C + C+ C + + S
Sbjct: 381 NNCSHGGTCQDLVNGFKCVCPPQWTG-----KTCQLDANECEAKPCVNAKSCKNLIASYY 435
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANAC 1412
C+C PGW G CD D CLG + C Y C C GY GD C+ D C
Sbjct: 436 CDCLPGWMGQNCDININD-CLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE---C 491
Query: 1413 SAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPC 1449
++ C +G ++ CLC GFSG CQ + NPC
Sbjct: 492 ASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPC 534
Score = 70.1 bits (170), Expect = 2e-11
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 6/116 (5%)
Query: 1334 SCTVC-KHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMC 1391
S VC HG C+S C+C G+TG C + D C + C + G C+ SY C
Sbjct: 595 SSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND-CESNPCRNGGTCIDGVNSYKC 653
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQEN 1447
C++G+ G C+ + N CS CH+G + YC C+ G+ G+ C +
Sbjct: 654 ICSDGWEGAYCET---NINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRD 706
Score = 67.8 bits (164), Expect = 8e-11
Identities = 41/123 (33%), Positives = 51/123 (41%), Gaps = 7/123 (5%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYM 1390
C S G C+ CEC PGWTGP C D C + C H G C +
Sbjct: 340 CLSDPCHNRGSCKETSL-GFECECSPGWTGPTCSTNI-DDCSPNNCSHGGTCQDLVNGFK 397
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPC 1449
C C + G C AN C A C + + + YC C PG+ G++C N C
Sbjct: 398 CVCPPQWTGKTCQL---DANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC 454
Query: 1450 LGQ 1452
LGQ
Sbjct: 455 LGQ 457
Score = 66.6 bits (161), Expect = 2e-10
Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 8/112 (7%)
Query: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGYGG 1399
G C + D C C G++GP C + A CL CH+ G C T + C+C+ G+ G
Sbjct: 310 GTCSNTGPDKYQCSCPEGYSGPNC-EIAEHACLSDPCHNRGSCKETSLGFECECSPGWTG 368
Query: 1400 DLCDNKNDSANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
C D CS C H G C G C+C P ++G+ CQ + N C
Sbjct: 369 PTCSTNIDD---CSPNNCSHGGTCQDLVNGFK-CVCPPQWTGKTCQLDANEC 416
Score = 60.5 bits (145), Expect = 1e-08
Identities = 47/160 (29%), Positives = 62/160 (38%), Gaps = 27/160 (16%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGH-RCHHGKCVATGTSYM 1390
C+ KHG C+ C C+ GW G CD+ C+ H C HG C +
Sbjct: 234 CRQGCSPKHGSCKLPGD----CRCQYGWQGLYCDK-----CIPHPGCVHGIC---NEPWQ 281
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFK--CHHGQCHISDQGEPYCLCQPGFSGEHCQ-QEN 1447
C C +GG LCD N C + + G C + + C C G+SG +C+ E+
Sbjct: 282 CLCETNWGGQLCDK---DLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEH 338
Query: 1448 PCLGQVVREVIRRQKGYASCATASKVPIMECR-GGCGPQC 1486
CL SC S EC G GP C
Sbjct: 339 ACLSDPCH-------NRGSCKETSLGFECECSPGWTGPTC 371
Score = 55.8 bits (133), Expect = 3e-07
Identities = 41/154 (26%), Positives = 58/154 (37%), Gaps = 42/154 (27%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
C S G C++ E + C C G++G LC + D C + C +G +C + Y
Sbjct: 491 CASNPCLNGGHCQN-EINRFQCLCPTGFSGNLCQLDI-DYCEPNPCQNGAQCYNRASDYF 548
Query: 1391 CKCAEGYGGDLCDNKND-----------------------------SANACSAFKCHHGQ 1421
CKC E Y G C + D S+N C HG+
Sbjct: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGP----HGK 604
Query: 1422 CHISDQGEPYCLCQPGFSGEHCQ------QENPC 1449
C G+ C C GF+G +C + NPC
Sbjct: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPC 638
Score = 55.8 bits (133), Expect = 3e-07
Identities = 45/185 (24%), Positives = 74/185 (40%), Gaps = 28/185 (15%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYM 1390
C++ C G+ +S C C GW G C+ D C + CH+ G C +
Sbjct: 638 CRNGGTCIDGV------NSYKCICSDGWEGAYCETNIND-CSQNPCHNGGTCRDLVNDFY 690
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPY-CLCQPGFSGEHCQ--QE 1446
C C G+ G C +++ + C C++ G C+ D+G+ + C+C G+ G C +
Sbjct: 691 CDCKNGWKGKTCHSRD---SQCDEATCNNGGTCY--DEGDAFKCMCPGGWEGTTCNIARN 745
Query: 1447 NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQCCQPTRSKRRKYVFQ---CT 1502
+ CL +C + C+ G GP C Q T + C
Sbjct: 746 SSCLPNPCH-------NGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCV 798
Query: 1503 DGSSF 1507
DG ++
Sbjct: 799 DGDNW 803
Score = 49.7 bits (117), Expect = 2e-05
Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 5/92 (5%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
C C PG+ G C+++ D C + C + G C + C C G+ G+LC D
Sbjct: 473 CICPPGYAGDHCERDI-DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDID---Y 528
Query: 1412 CSAFKCHHGQCHISDQGEPYCLCQPGFSGEHC 1443
C C +G + + +C C + G++C
Sbjct: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 195 bits (495), Expect = 3e-49
Identities = 159/602 (26%), Positives = 225/602 (37%), Gaps = 130/602 (21%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S+PC N+ C D + ++C C + G C I+ C +PC +GG C
Sbjct: 515 NECASAPCLNHADC-HDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQ---DQP 570
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
F C C GFEG RC+ D+C + C A+C+D + C+CP +TG+LC+ +
Sbjct: 571 GAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE--VPL 628
Query: 1038 CVPELNLCQ---------HEAKCIPLD-------------------KGFSCECVPGYSGK 1069
C P NLCQ +A C+ D + SC C G++G
Sbjct: 629 CAP--NLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGP 686
Query: 1070 LCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE------------------- 1110
CE + C++ C HG C +GY CTCP G++GP C
Sbjct: 687 ECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNP 746
Query: 1111 ------------HPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
H P T C C NG C+ +C C GF GPRCE
Sbjct: 747 SPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE--- 803
Query: 1159 TVNFVGKDSYVELASAKVRPQANIS--LQVATDKDNGILLYKGDNDPLALELYQGHVRLV 1216
K+RP S AT +D+ +G G + +
Sbjct: 804 ---------------GKLRPSCADSPCRNRATCQDSP----QGPRCLCPTGYTGGSCQTL 844
Query: 1217 YDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTL-NLVVDKGTPKSLGKLQKQPAVGINS 1275
D + P S FH + L L NL + S K + ++S
Sbjct: 845 MDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLS-----SCQKAALSQGIDVSS 899
Query: 1276 PLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSC 1335
+ GG+ +G S GF G + + +N C+S
Sbjct: 900 LCHNGGLCVDSGPSYFCHCPP----GFQGSLCQDHVNP------------------CES- 936
Query: 1336 TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH-HGKCVATGTSYMCKCA 1394
C++G + +C+C PG+ G C +E D C CH HG C + C C
Sbjct: 937 RPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL-DACQSQPCHNHGTCTPKPGGFHCACP 995
Query: 1395 EGYGGDLCDNKNDSANACSAFKCH---HGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCL 1450
G+ G C+ D C CH CH S YC C PG +G+ C+ E +PC
Sbjct: 996 PGFVGLRCEGDVDE---CLDQPCHPTGTAACH-SLANAFYCQCLPGHTGQWCEVEIDPCH 1051
Query: 1451 GQ 1452
Q
Sbjct: 1052 SQ 1053
Score = 173 bits (439), Expect = 1e-42
Identities = 86/245 (35%), Positives = 118/245 (48%), Gaps = 15/245 (6%)
Query: 918 NACLSSP--CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS 975
N C P C GT + + ++C CP +G C + C C +GGTC L
Sbjct: 196 NECFQDPGPCPK-GTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPE 254
Query: 976 HKDGFS-CSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEV 1034
F C CP GF G CE+NPD+C + C+N TC DG++ Y C+CP +TG C E
Sbjct: 255 KDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSED 314
Query: 1035 IDHCVPE-LNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTI 1093
+D C + C++ C F C CV G+ G CE + DDC+A C G+ C+D +
Sbjct: 315 VDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRV 374
Query: 1094 NGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIV--VQQEPTCRCPPGFAG 1151
++C CP G +G C H M L Q C AQC + C C PG++G
Sbjct: 375 GSFSCLCPPGRTGLLC-HLEDMCLSQ-------PCHGDAQCSTNPLTGSTLCLCQPGYSG 426
Query: 1152 PRCEK 1156
P C +
Sbjct: 427 PTCHQ 431
Score = 173 bits (439), Expect = 1e-42
Identities = 94/304 (30%), Positives = 135/304 (44%), Gaps = 26/304 (8%)
Query: 860 HCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDIN--IVAKC 917
HC C W + + A C+ DR+ F C P +
Sbjct: 340 HCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRV------GSFSCLCPPGRTGLLCHLE 393
Query: 918 NACLSSPCKNNGTCTQDPVE-LYRCACPYSYKGKDCTVPINTCIQ-----NPCQHGGTCH 971
+ CLS PC + C+ +P+ C C Y G C ++ C+ +PC+HGG+C
Sbjct: 394 DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCL 453
Query: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
+ F+C CP G+ G RCE + ++C C +TC+D + + C+CPP G+LC
Sbjct: 454 NTPG---SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLC 510
Query: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
+ + C C + A C L GF C C+PG+SG CE D D+C + C +G QC D
Sbjct: 511 EVETNECASAP--CLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQD 568
Query: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
+ C C GF GP C+ + C C GA C+ + C CP GF G
Sbjct: 569 QPGAFHCKCLPGFEGPRCQ-------TEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTG 621
Query: 1152 PRCE 1155
CE
Sbjct: 622 QLCE 625
Score = 173 bits (438), Expect = 1e-42
Identities = 92/285 (32%), Positives = 126/285 (44%), Gaps = 28/285 (9%)
Query: 887 PEPMADRLLLTTPTHRFQC----KGPVDINIVAKCNAC-------LSSPCKNNGTCTQDP 935
P P L T P+ C GP+ ++ C +SS C N G C D
Sbjct: 852 PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCV-DS 910
Query: 936 VELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEI 995
Y C CP ++G C +N C PCQ+G TC S G+ C C G++GQ C
Sbjct: 911 GPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPS---GYLCQCAPGYDGQNCSK 967
Query: 996 NPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLD 1055
D C+ C N+ TC + C CPP + G C+ +D C+ + A C L
Sbjct: 968 ELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLA 1027
Query: 1056 KGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN---GYTCTCPQGFSGPFCEHP 1112
F C+C+PG++G+ CE + D C + C HG C T G+ C CP+GF GP C H
Sbjct: 1028 NAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHR 1087
Query: 1113 PPMVLLQTSPCDQYECQNGAQCIVVQQ---EPTCRCPPGFAGPRC 1154
P C + C +G C+ + P C C G+ GP C
Sbjct: 1088 AP-------SCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDC 1125
Score = 172 bits (436), Expect = 2e-42
Identities = 89/282 (31%), Positives = 131/282 (46%), Gaps = 56/282 (19%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC-IQNP--CQHGGTCHLSDSH 976
C+S C+N GTC QD ++ Y C CP ++ G DC+ ++ C Q P C++GGTC S
Sbjct: 280 CVSHQCQNGGTC-QDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAG- 337
Query: 977 KDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPN----------- 1025
F C C G+ G CE N DDC C +TC+D + ++ C+CPP
Sbjct: 338 --SFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM 395
Query: 1026 ----------------------------YTGELCDEVIDHCVPEL---NLCQHEAKCIPL 1054
Y+G C + +D C+ + C+H C+
Sbjct: 396 CLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNT 455
Query: 1055 DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPP 1114
F+C C PGY+G CE D+++C++ C G+ C+D + + C CP G G CE
Sbjct: 456 PGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCE---- 511
Query: 1115 MVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
++T+ C C N A C + C C PGF+G RCE+
Sbjct: 512 ---VETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEE 550
Score = 171 bits (433), Expect = 5e-42
Identities = 91/273 (33%), Positives = 128/273 (46%), Gaps = 19/273 (6%)
Query: 880 GIARCSSPEPMADRLLLTTPTHRFQ-CKGPVDINIVAKCNACLSSPCKNNGTCTQDPVEL 938
G A+CS+ L L P + C +D ++A+ SPC++ G+C P
Sbjct: 403 GDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGP---SPCEHGGSCLNTPGS- 458
Query: 939 YRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPD 998
+ C CP Y G C N C+ PC G TC F C CP G EGQ CE+ +
Sbjct: 459 FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCL---DLLATFHCLCPPGLEGQLCEVETN 515
Query: 999 DCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGF 1058
+C C N+A C D +N + CIC P ++G C+E ID C + C + +C F
Sbjct: 516 ECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDEC--RSSPCANGGQCQDQPGAF 573
Query: 1059 SCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLL 1118
C+C+PG+ G C+T+ D+C++ C GA C+D + C CP GF+G CE P
Sbjct: 574 HCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVP------ 627
Query: 1119 QTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
C CQ C + + C CP G G
Sbjct: 628 ---LCAPNLCQPKQICKDQKDKANCLCPDGSPG 657
Score = 163 bits (412), Expect = 1e-39
Identities = 149/574 (25%), Positives = 207/574 (36%), Gaps = 116/574 (20%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQ-------------- 965
CLS PC +C P + C CP + G+ C VP+ C N CQ
Sbjct: 593 CLSDPCPVGASCLDLPGAFF-CLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQKDKANC 649
Query: 966 -------------HGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012
TCH H SC C +G+ G CE C C + TC
Sbjct: 650 LCPDGSPGCAPPEDNCTCH--HGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCY 707
Query: 1013 DGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
+ Y C CP YTG C E + C C + C P G+ C C P ++G C+
Sbjct: 708 PQPSGYNCTCPTGYTGPTCSEEMTAC--HSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 765
Query: 1073 TDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132
T D CV+ C +G CV+ ++C C GF GP CE L+ S C C+N A
Sbjct: 766 TSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGK-----LRPS-CADSPCRNRA 819
Query: 1133 QCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKD--SYVELASAKVRPQANISLQVATDK 1190
C Q P GPRC L + G + ++L + K P+ + LQ T
Sbjct: 820 TC---QDSPQ--------GPRC--LCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQ--TGP 864
Query: 1191 DNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTL 1250
L +G PL + P + ++ G +++ +L
Sbjct: 865 SFHCLCLQGWTGPLC----------------NLPLSSCQKAALSQG----IDVSSLCHNG 904
Query: 1251 NLVVDKGT-------PKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFH 1303
L VD G P G L + S P G + + Q P G
Sbjct: 905 GLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESR------PCQNGATCMAQ----PSGYLC 954
Query: 1304 GCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPL 1363
C N ++ A C+S HG C + + C C PG+ G
Sbjct: 955 QCAPGYDGQNCSKELDA-----------CQSQPCHNHGTC-TPKPGGFHCACPPGFVGLR 1002
Query: 1364 CDQEARDPCLGHRCHH---GKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHG 1420
C+ + D CL CH C + ++ C+C G+ G C+ + D C + C HG
Sbjct: 1003 CEGDV-DECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDP---CHSQPCFHG 1058
Query: 1421 QCHISDQGEPY---CLCQPGFSGEHCQQENPCLG 1451
+ G P C C GF G C P G
Sbjct: 1059 GTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCG 1092
Score = 154 bits (389), Expect = 6e-37
Identities = 83/282 (29%), Positives = 110/282 (39%), Gaps = 52/282 (18%)
Query: 919 ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKD 978
+C SPC+N TC QD + RC CP Y G C ++ C Q PC C +
Sbjct: 809 SCADSPCRNRATC-QDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGP--- 864
Query: 979 GFSCSCPLGFEGQRCEINPDDCE----------DNDCENNATCVDGINNYVCICPPNYTG 1028
F C C G+ G C + C+ + C N CVD +Y C CPP + G
Sbjct: 865 SFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQG 924
Query: 1029 ELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQ 1088
LC + ++ C E CQ+ A C+ G+ C+C PGY G+ C + D C + C +
Sbjct: 925 SLCQDHVNPC--ESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGT 982
Query: 1089 CVDTINGYTCTCPQGFSGPFCE---------------------------------HPPPM 1115
C G+ C CP GF G CE H
Sbjct: 983 CTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQW 1042
Query: 1116 VLLQTSPCDQYECQNGAQCIVVQQEP---TCRCPPGFAGPRC 1154
++ PC C +G C P C CP GF GP C
Sbjct: 1043 CEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTC 1084
Score = 139 bits (350), Expect = 2e-32
Identities = 80/251 (31%), Positives = 108/251 (43%), Gaps = 29/251 (11%)
Query: 924 PCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH--------LSDS 975
PC N GTC + C C + G+ C P CQ+GG+C L S
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 976 HK---DGFSCSCPLGFEGQRCEINPDD-CEDNDCENNATC-VDGINNYVCICPPNYTGEL 1030
F C+C GF G+RC+ +D C + C C + C C P +TGE
Sbjct: 94 PSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQ 153
Query: 1031 CDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAH--KCRHGAQ 1088
C ++ D C N C + C+ C C PG+ G CE D ++C C G
Sbjct: 154 C-QLRDFC--SANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT----CR 1144
C +T+ + C CP G GP CE L+ PC C NG C ++ ++ + C
Sbjct: 211 CHNTLGSFQCLCPVGQEGPRCE-------LRAGPCPPRGCSNGGTCQLMPEKDSTFHLCL 263
Query: 1145 CPPGFAGPRCE 1155
CPPGF GP CE
Sbjct: 264 CPPGFIGPDCE 274
Score = 131 bits (330), Expect = 4e-30
Identities = 94/350 (26%), Positives = 141/350 (40%), Gaps = 55/350 (15%)
Query: 837 SVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMAD---- 892
S PE N T LS L+LG C C+ +L E C P+P +
Sbjct: 30 SFPEPCANGGTCLS-LSLGQGT--CQCAPGFLGE------------TCQFPDPCQNAQLC 74
Query: 893 ------RLLLTTPTHRFQCKGPVDINIVAKC--------------NACLSSPCKNNGTCT 932
+ LL P P+ + + C + C S C G C
Sbjct: 75 QNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCH 134
Query: 933 QDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQR 992
+C+C + G+ C + + C NPC +GG C + C CP GFEG
Sbjct: 135 IQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATYPQ---IQCHCPPGFEGHA 190
Query: 993 CEINPDDC--EDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAK 1050
CE + ++C + C +C + + ++ C+CP G C+ C P C +
Sbjct: 191 CERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPP--RGCSNGGT 248
Query: 1051 CIPLDKGFS----CECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSG 1106
C + + S C C PG+ G CE + D+CV+H+C++G C D ++ YTC CP+ ++G
Sbjct: 249 CQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTG 308
Query: 1107 PFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
C Q P C+NG C C C G+ G CE+
Sbjct: 309 WDCSEDVDECETQGPP----HCRNGGTCQNSAGSFHCVCVSGWGGTSCEE 354
Score = 123 bits (308), Expect = 2e-27
Identities = 74/250 (29%), Positives = 95/250 (38%), Gaps = 63/250 (25%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S PC+N TC P Y C C Y G++C+ ++ C PC + GTC
Sbjct: 932 NPCESRPCQNGATCMAQPSG-YLCQCAPGYDGQNCSKELDACQSQPCHNHGTC---TPKP 987
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCE--NNATCVDGINNYVCICPPNYTGELCDEVI 1035
GF C+CP GF G RCE + D+C D C A C N + C C P +TG+ C+ I
Sbjct: 988 GGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEI 1047
Query: 1036 DHCVPELNLCQHEAKC-----IPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCV 1090
D C + C H C PL GF C C G+ G C C H C HG C+
Sbjct: 1048 DPCHSQP--CFHGGTCEATAGSPL--GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCL 1103
Query: 1091 DTIN------------------------------------------------GYTCTCPQ 1102
+ G+ C+CP
Sbjct: 1104 PSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPH 1163
Query: 1103 GFSGPFCEHP 1112
GP C+ P
Sbjct: 1164 SSPGPRCQKP 1173
Score = 84.3 bits (207), Expect = 8e-16
Identities = 54/168 (32%), Positives = 77/168 (45%), Gaps = 13/168 (7%)
Query: 1324 QSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KC 1382
Q +S G ++C +G S C C PG+ G LC Q+ +PC C +G C
Sbjct: 887 QKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLC-QDHVNPCESRPCQNGATC 945
Query: 1383 VATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCH-HGQCHISDQGEPYCLCQPGFSGE 1441
+A + Y+C+CA GY G C + D AC + CH HG C G +C C PGF G
Sbjct: 946 MAQPSGYLCQCAPGYDGQNCSKELD---ACQSQPCHNHGTC-TPKPGGFHCACPPGFVGL 1001
Query: 1442 HCQQE-NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQ 1488
C+ + + CL Q G A+C + + +C G Q C+
Sbjct: 1002 RCEGDVDECLDQPCHPT-----GTAACHSLANAFYCQCLPGHTGQWCE 1044
Score = 78.2 bits (191), Expect = 6e-14
Identities = 57/182 (31%), Positives = 71/182 (39%), Gaps = 25/182 (13%)
Query: 1322 PPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHG 1380
P S G +P +CT C HG C+ C C GWTGP C+ E C+ C H G
Sbjct: 652 PDGSPGCAPPEDNCT-CHHGHCQRSS-----CVCDVGWTGPECEAEL-GGCISAPCAHGG 704
Query: 1381 KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG 1440
C + Y C C GY G C ++ AC + C +G G YC C P +G
Sbjct: 705 TCYPQPSGYNCTCPTGYTGPTC---SEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTG 761
Query: 1441 EHCQQEN------PCL--GQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCC-QPTR 1491
CQ PC G V + G SC A C G P C P R
Sbjct: 762 PQCQTSTDYCVSAPCFNGGTCV-----NRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCR 816
Query: 1492 SK 1493
++
Sbjct: 817 NR 818
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/173 (30%), Positives = 72/173 (41%), Gaps = 24/173 (13%)
Query: 1353 CECRPGWTGPLCD------QEA---RDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLC 1402
C C GWTGPLC+ Q+A + + CH+G CV +G SY C C G+ G LC
Sbjct: 868 CLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLC 927
Query: 1403 DNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQVVRE--VIR 1459
D N C + C +G ++ C C PG+ G++C +E + C Q
Sbjct: 928 Q---DHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCT 984
Query: 1460 RQKGYASCATASKVPIMECRGG---CGPQCCQPT-----RSKRRKYVFQCTDG 1504
+ G CA + C G C Q C PT S + QC G
Sbjct: 985 PKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPG 1037
Score = 71.2 bits (173), Expect = 7e-12
Identities = 40/113 (35%), Positives = 55/113 (48%), Gaps = 16/113 (14%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHR-----CHHG-KCVATGTSYMCKCAEGYGGDLCD 1403
S +C C+PG++GP C Q+ D CL + C HG C+ T S+ C C GY G C+
Sbjct: 415 STLCLCQPGYSGPTCHQDL-DECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Query: 1404 NKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQEN------PCL 1450
+ N C + CH G + +CLC PG G+ C+ E PCL
Sbjct: 474 ADH---NECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCL 523
Score = 68.9 bits (167), Expect = 3e-11
Identities = 42/131 (32%), Positives = 57/131 (43%), Gaps = 24/131 (18%)
Query: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHG-KCVAT------------- 1385
G C S+ C+C PG+ G C + DPC + C +G C A
Sbjct: 39 GTCLSLSLGQGTCQCAPGFLGETC--QFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSP 96
Query: 1386 -GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
S++C C G+ G+ C K + S F G+CHI G P C C PG++GE CQ
Sbjct: 97 LTPSFLCTCLPGFTGERCQAKLEDPCPPS-FCSKRGRCHIQASGRPQCSCMPGWTGEQCQ 155
Query: 1445 -----QENPCL 1450
NPC+
Sbjct: 156 LRDFCSANPCV 166
Score = 68.9 bits (167), Expect = 3e-11
Identities = 53/168 (31%), Positives = 66/168 (39%), Gaps = 24/168 (14%)
Query: 1328 VSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH----GKCV 1383
VS C++ C+ GL D+ C C WTG C ++ D C H G C
Sbjct: 281 VSHQCQNGGTCQDGL------DTYTCLCPETWTGWDCSEDV-DECETQGPPHCRNGGTCQ 333
Query: 1384 ATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHC 1443
+ S+ C C G+GG C+ D C A C G I G CLC PG +G C
Sbjct: 334 NSAGSFHCVCVSGWGGTSCEENLDD---CIAATCAPGSTCIDRVGSFSCLCPPGRTGLLC 390
Query: 1444 QQENPCLGQVVREVIRRQKGYASCATASKVPIMEC---RGGCGPQCCQ 1488
E+ CL Q G A C+T C G GP C Q
Sbjct: 391 HLEDMCLSQPCH-------GDAQCSTNPLTGSTLCLCQPGYSGPTCHQ 431
Score = 65.5 bits (158), Expect = 4e-10
Identities = 39/109 (35%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGT---SYMCKCAEGYGGDLCDNKN 1406
S C C PG TG LC E D CL CH +T S +C C GY G C
Sbjct: 376 SFSCLCPPGRTGLLCHLE--DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDL 433
Query: 1407 DSANACSA--FKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQ 1452
D C HG ++ G CLC PG++G C+ + N CL Q
Sbjct: 434 DECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQ 482
Score = 63.9 bits (154), Expect = 1e-09
Identities = 53/184 (28%), Positives = 67/184 (36%), Gaps = 34/184 (18%)
Query: 1353 CECRPGWTGPLCDQEARD----PCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
C C PG G LC+ E + PCL +H C + C C G+ G C+ D
Sbjct: 499 CLCPPGLEGQLCEVETNECASAPCL----NHADCHDLLNGFQCICLPGFSGTRCEEDIDE 554
Query: 1409 ANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQVVREVIRRQKGYAS 1466
C + C + GQC G +C C PGF G CQ E + CL AS
Sbjct: 555 ---CRSSPCANGGQCQ-DQPGAFHCKCLPGFEGPRCQTEVDECLSDPC-------PVGAS 603
Query: 1467 CATASKVPIMECRGG----------CGPQCCQP---TRSKRRKYVFQCTDGSSFVEEVER 1513
C C G C P CQP + ++ K C DGS E
Sbjct: 604 CLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPED 663
Query: 1514 HLEC 1517
+ C
Sbjct: 664 NCTC 667
Score = 63.9 bits (154), Expect = 1e-09
Identities = 54/191 (28%), Positives = 75/191 (39%), Gaps = 29/191 (15%)
Query: 1330 PGC-KSCTVCKHGLCRS-----VEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KC 1382
P C + T C G C + C C P TGP C Q + D C+ C +G C
Sbjct: 724 PTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQC-QTSTDYCVSAPCFNGGTC 782
Query: 1383 VATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGE 1441
V ++ C CA G+ G C+ K +C+ C + C S QG P CLC G++G
Sbjct: 783 VNRPGTFSCLCAMGFQGPRCEGK--LRPSCADSPCRNRATCQDSPQG-PRCLCPTGYTGG 839
Query: 1442 HCQ------QENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRR 1495
CQ + PC + T + +G GP C P S ++
Sbjct: 840 SCQTLMDLCAQKPC-----------PRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQK 888
Query: 1496 KYVFQCTDGSS 1506
+ Q D SS
Sbjct: 889 AALSQGIDVSS 899
Score = 63.2 bits (152), Expect = 2e-09
Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 17/144 (11%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
C C G+TG C Q D C C + C+ TG S+ C C +G+ G LC+ S
Sbjct: 830 CLCPTGYTGGSC-QTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQK 888
Query: 1412 CSAFK-------CHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPCLGQVVREVIRRQKG 1463
+ + CH+G + +C C PGF G CQ NPC R +
Sbjct: 889 AALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCES-------RPCQN 941
Query: 1464 YASCATASKVPIMECRGGCGPQCC 1487
A+C + +C G Q C
Sbjct: 942 GATCMAQPSGYLCQCAPGYDGQNC 965
Score = 62.4 bits (150), Expect = 3e-09
Identities = 42/133 (31%), Positives = 58/133 (43%), Gaps = 15/133 (11%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEG 1396
C++G S C C GW G C +E D C+ C G C+ S+ C C G
Sbjct: 326 CRNGGTCQNSAGSFHCVCVSGWGGTSC-EENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384
Query: 1397 YGGDLCDNKNDSANACSAFKCH-HGQCHISD-QGEPYCLCQPGFSGEHCQQENPCLGQVV 1454
G LC + + C + CH QC + G CLCQPG+SG C Q+ +
Sbjct: 385 RTGLLCHLE----DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQD-------L 433
Query: 1455 REVIRRQKGYASC 1467
E + Q+G + C
Sbjct: 434 DECLMAQQGPSPC 446
Score = 62.0 bits (149), Expect = 4e-09
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 7/103 (6%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCH-HGKC-VATGTSYMCKCAEGYGGDLCDNKND 1407
S +C C PG+TG C + DPC C G+C + C C G+ G+ C ++
Sbjct: 100 SFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRD- 158
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
CSA C +G ++ + C C PGF G C+++ N C
Sbjct: 159 ---FCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNEC 198
Score = 61.2 bits (147), Expect = 7e-09
Identities = 40/123 (32%), Positives = 49/123 (39%), Gaps = 11/123 (8%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C K G C C C PGWTG C + RD C + C + G C+AT
Sbjct: 122 CPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC--QLRDFCSANPCVNGGVCLATYPQIQ 179
Query: 1391 CKCAEGYGGDLCDNKNDSANAC--SAFKCHHG-QCHISDQGEPYCLCQPGFSGEHCQ-QE 1446
C C G+ G C+ N C C G CH + G CLC G G C+ +
Sbjct: 180 CHCPPGFEGHACER---DVNECFQDPGPCPKGTSCH-NTLGSFQCLCPVGQEGPRCELRA 235
Query: 1447 NPC 1449
PC
Sbjct: 236 GPC 238
Score = 60.1 bits (144), Expect = 2e-08
Identities = 44/151 (29%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 1299 LGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSV-EKDSV--VCEC 1355
LG F C+ V + +A P G S G G C+ + EKDS +C C
Sbjct: 215 LGSFQ-CLCPVGQEGPRCELRAGPCPPRGCSNG---------GTCQLMPEKDSTFHLCLC 264
Query: 1356 RPGWTGPLCDQEARDPCLGHRCHHGKCVATGT-SYMCKCAEGYGGDLCDNKNDSANACSA 1414
PG+ GP C+ D C+ H+C +G G +Y C C E + G C D
Sbjct: 265 PPGFIGPDCEVNP-DNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGP 323
Query: 1415 FKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
C +G + G +C+C G+ G C++
Sbjct: 324 PHCRNGGTCQNSAGSFHCVCVSGWGGTSCEE 354
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/119 (30%), Positives = 46/119 (38%), Gaps = 12/119 (10%)
Query: 1338 CKHG-LCRSVEKDSV--VCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVAT---GTSYM 1390
C HG C + + +C C G+ GP C A C H CHH G C+ + G
Sbjct: 1055 CFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA-PSCGFHHCHHGGLCLPSPKPGFPPR 1113
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKC-HHGQC-HISDQGEP--YCLCQPGFSGEHCQQ 1445
C C GYGG C C ++G C + G P C C G CQ+
Sbjct: 1114 CACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQK 1172
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 194 bits (492), Expect = 7e-49
Identities = 152/580 (26%), Positives = 229/580 (39%), Gaps = 133/580 (22%)
Query: 902 RFQCKGPVD---INIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT 958
R++C P+ + + + C S+PC + G+C D V +RC C Y G C + ++
Sbjct: 129 RYECHCPLGYAGVTCEMEVDECASAPCLHGGSCL-DGVGSFRCVCAPGYGGTRCQLDLDE 187
Query: 959 CIQNPCQHGGTCH--------------LSDSHKD----------------------GFSC 982
C PC HGGTCH +H + F C
Sbjct: 188 CQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRC 247
Query: 983 SCPLGFEGQRCEINPDDCEDNDCENNATCVD--------GIN-------------NYVCI 1021
C G+ G+ CE++ D+C + C++ C+ G+ ++C
Sbjct: 248 LCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCH 307
Query: 1022 CPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAH 1081
CPP + G C +D C C + C L GF C C GY+G CE D D+C++
Sbjct: 308 CPPGFEGADCGVEVDECASRP--CLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSD 365
Query: 1082 KCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEP 1141
C HG C DT+ GY C CP+ + G C +Q + C + C A CI + +
Sbjct: 366 PCLHGGTCSDTVAGYICRCPETWGGRDCS-------VQLTGCQGHTCPLAATCIPIFESG 418
Query: 1142 ----TCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLY 1197
C CPPG GP C + T + + AS ++L+ T G L
Sbjct: 419 VHSYVCHCPPGTHGPFCGQNTTFSVMAGSPI--QASVPAGGPLGLALRFRTTLPAGTLAT 476
Query: 1198 KGD-NDPLALELYQGHVRLVYDSLSSPPTTVYSVE----TVNDGQFHSVELVTLNQTLNL 1252
+ D + L L L ++ +L S TTV + +NDG +H VE+V TL L
Sbjct: 477 RNDTKESLELALVAATLQA---TLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLEL 533
Query: 1253 -VVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRI 1311
+ +G P L A+ + P G+S+ + G F GC+ +VR+
Sbjct: 534 RLWHEGCPARLCVASGPVALASTA----SATPLPAGISSAQLGD----ATFAGCLQDVRV 585
Query: 1312 NNELQDFKALPPQSLG--VSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEAR 1369
+ L L P+ LG V GC+ C+ PL
Sbjct: 586 DGHL-----LLPEDLGENVLLGCERREQCR----------------------PL------ 612
Query: 1370 DPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSA 1409
PC+ H G CV T + C CA + G C ++ +A
Sbjct: 613 -PCV----HGGSCVDLWTHFRCDCARPHRGPTCADEIPAA 647
Score = 158 bits (399), Expect = 4e-38
Identities = 79/239 (33%), Positives = 103/239 (43%), Gaps = 20/239 (8%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
+AC S PC C Y C P +G C PC HG C
Sbjct: 40 SACASDPCAPGTECQATESGGYTCG-PMEPRG---------CATQPCHHGALCVPQGPDP 89
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
GF C C GF+G RCE++ D+C C + ATC + + Y C CP Y G C+ +D
Sbjct: 90 TGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDE 149
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C C H C+ F C C PGY G C+ D D+C + C HG C D +NG+
Sbjct: 150 CASA--PCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFR 207
Query: 1098 CTCP-QGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
C C G+ G CE + C C++ A C+ C C PG++G CE
Sbjct: 208 CDCAGTGYEGTHCER-------EVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Score = 91.3 bits (225), Expect = 7e-18
Identities = 55/192 (28%), Positives = 76/192 (39%), Gaps = 43/192 (22%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C SPC ++G C +D + + CAC ++G C ++ C PC G CH +H DG
Sbjct: 1060 CAPSPCLHDGAC-RDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCH---THPDG 1114
Query: 980 -FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHC 1038
F C CP GF G RC + +C N TC+DG
Sbjct: 1115 RFECRCPPGFGGPRCRL---PVPSKECSLNVTCLDG------------------------ 1147
Query: 1039 VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
+ C +C C+ G +G+ C+ C A+ C +G C C
Sbjct: 1148 ----------SPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSEC 1197
Query: 1099 TCPQGFSGPFCE 1110
C FSG FCE
Sbjct: 1198 ICNARFSGQFCE 1209
Score = 89.7 bits (221), Expect = 2e-17
Identities = 106/409 (25%), Positives = 137/409 (33%), Gaps = 68/409 (16%)
Query: 1076 DDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHP---PPMVLLQTSPCDQYECQNGA 1132
D C C +G C+ T N + CTCP F+GP C P L + C+ E +G
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCE--EVPDGF 866
Query: 1133 QCIVVQQEPTCR--CPPGFAGPRCEKL-----ITVNFVGKDSYVELASAKVRPQANISLQ 1185
C+ E T R P F+G +++ F +DS L A + L
Sbjct: 867 VCVA---EATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLA 923
Query: 1186 VATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVE--TVNDGQFHSVEL 1243
V N LA + GH P V + V DG +H V L
Sbjct: 924 VR-------------NGSLAGGVRGGH---------GLPGAVLPIPGPRVADGAWHRVRL 961
Query: 1244 VT-------------LNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSA 1290
L+ V +G LG LQ AV I G L
Sbjct: 962 AMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGG 1021
Query: 1291 LRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGV--SPGCKSCTVCKHGLCRSVEK 1348
L RP G E + P LG +P C G CR +
Sbjct: 1022 LPLPLARPRPGAAPGARE-----HFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLF- 1075
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKC-VATGTSYMCKCAEGYGGDLCDNKND 1407
D+ C C PGW GP C+ DPC C G+C + C+C G+GG C
Sbjct: 1076 DAFACACGPGWEGPRCEAHV-DPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVP 1134
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPCL 1450
S C G C C G +G+ CQ + NPCL
Sbjct: 1135 SKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCL 1183
Score = 76.3 bits (186), Expect = 2e-13
Identities = 45/165 (27%), Positives = 64/165 (38%), Gaps = 24/165 (14%)
Query: 1000 CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIP------ 1053
C + C ++ C D + + C C P + G C+ +D C H A C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPC--------HSAPCARGRCHTH 1111
Query: 1054 LDKGFSCECVPGYSGKLCE--TDNDDCVAH-KCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
D F C C PG+ G C + +C + C G+ C C+C +G +G C+
Sbjct: 1112 PDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQ 1171
Query: 1111 HPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
P T PC+ C NG C C C F+G CE
Sbjct: 1172 VP-------TLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 73.9 bits (180), Expect = 1e-12
Identities = 42/122 (34%), Positives = 54/122 (44%), Gaps = 14/122 (11%)
Query: 1338 CKHG-LC--RSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKC 1393
C HG LC + + C C PG+ GP C+ + D C CHHG C Y C C
Sbjct: 76 CHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDI-DECASRPCHHGATCRNLADRYECHC 134
Query: 1394 AEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QEN 1447
GY G C+ + D C++ C HG + G C+C PG+ G CQ Q
Sbjct: 135 PLGYAGVTCEMEVDE---CASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQ 191
Query: 1448 PC 1449
PC
Sbjct: 192 PC 193
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/112 (35%), Positives = 50/112 (44%), Gaps = 8/112 (7%)
Query: 1338 CKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAE 1395
C HG CR++ D C C G+ G C+ E D C C H G C+ S+ C CA
Sbjct: 117 CHHGATCRNLA-DRYECHCPLGYAGVTCEMEV-DECASAPCLHGGSCLDGVGSFRCVCAP 174
Query: 1396 GYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
GYGG C D C + C H G CH G G+ G HC++E
Sbjct: 175 GYGGTRCQLDLDE---CQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCERE 223
Score = 55.8 bits (133), Expect = 3e-07
Identities = 89/423 (21%), Positives = 131/423 (30%), Gaps = 96/423 (22%)
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANI 1182
C C NG C+V + C CP F GP C + + + + A+ + P +
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL---WCPGQPCLPPATCEEVPDGFV 867
Query: 1183 SLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVE 1242
+ AT ++ + G N L G + L + + S + + +G + +V
Sbjct: 868 CVAEATFREGPPAAFSGHNASSGRLL--GGLSLAFRTRDSEAWLLRAAAGALEGVWLAVR 925
Query: 1243 LVTLNQTLN---------------LVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTG 1287
+L + V D + +++ A L+L G T
Sbjct: 926 NGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVA 985
Query: 1288 LSALRQ--------GTDRPL--GGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTV 1337
L L G R L F GC+ V + P G +PG +
Sbjct: 986 LRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRP---GAAPGAREHFA 1042
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGY 1397
G + + CR P+C A PCL H G C ++ C C G+
Sbjct: 1043 SWPGT------PAPILGCRGA---PVC---APSPCL----HDGACRDLFDAFACACGPGW 1086
Query: 1398 GGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREV 1457
G C+ D C + C G+CH G C C PGF
Sbjct: 1087 EGPRCEAHVDP---CHSAPCARGRCHTHPDGRFECRCPPGFG------------------ 1125
Query: 1458 IRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLEC 1517
GP+C P SK C DGS E C
Sbjct: 1126 -------------------------GPRCRLPVPSKECSLNVTCLDGSP-CEGGSPAANC 1159
Query: 1518 GCL 1520
CL
Sbjct: 1160 SCL 1162
Score = 55.1 bits (131), Expect = 5e-07
Identities = 36/119 (30%), Positives = 47/119 (39%), Gaps = 10/119 (8%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
C S G C+ + + C C G+ GP C+++ D CL C H G C T Y+
Sbjct: 324 CASRPCLNGGHCQDLP-NGFQCHCPDGYAGPTCEEDV-DECLSDPCLHGGTCSDTVAGYI 381
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHI----SDQGEPYCLCQPGFSGEHCQQ 1445
C+C E +GG C + C C I S C C PG G C Q
Sbjct: 382 CRCPETWGGRDC---SVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQ 437
Score = 53.5 bits (127), Expect = 2e-06
Identities = 35/105 (33%), Positives = 45/105 (42%), Gaps = 10/105 (9%)
Query: 897 TTPTHRFQCKGPVDINIVAKCNACL-SSPCKNNGTCTQ-DPVE----LYRCACPYSYKGK 950
T P RF+C+ P +C + S C N TC P E C+C G+
Sbjct: 1110 THPDGRFECRCPPGFG-GPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168
Query: 951 DCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEI 995
C VP C NPC +GGTC + + C C F GQ CE+
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVSE---CICNARFSGQFCEV 1210
Score = 50.4 bits (119), Expect = 1e-05
Identities = 40/148 (27%), Positives = 56/148 (37%), Gaps = 34/148 (22%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECR-PGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSY 1389
C+S G C + + C+C G+ G C++E + C C H+ C+ S+
Sbjct: 188 CQSQPCAHGGTCHDLV-NGFRCDCAGTGYEGTHCEREVLE-CASAPCEHNASCLEGLGSF 245
Query: 1390 MCKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPY----------------- 1431
C C GY G+LC+ D C++ C H G+C Y
Sbjct: 246 RCLCWPGYSGELCEVDEDE---CASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAA 302
Query: 1432 ---CLCQPGFSGEHCQQE------NPCL 1450
C C PGF G C E PCL
Sbjct: 303 GFLCHCPPGFEGADCGVEVDECASRPCL 330
Score = 49.3 bits (116), Expect = 3e-05
Identities = 29/102 (28%), Positives = 39/102 (38%), Gaps = 6/102 (5%)
Query: 1352 VCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSAN 1410
+C C PG+ G C E D C C + G C + C C +GY G C+ + +
Sbjct: 305 LCHCPPGFEGADCGVEV-DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCE---EDVD 360
Query: 1411 ACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLG 1451
C + C HG C C + G C Q C G
Sbjct: 361 ECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQG 402
Score = 48.5 bits (114), Expect = 5e-05
Identities = 64/276 (23%), Positives = 98/276 (35%), Gaps = 55/276 (19%)
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVR----P 1178
C C +G C+ + C C GP C I G AS ++ P
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGP 668
Query: 1179 QANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQF 1238
+S + T + G+LL ++ L ++ R+ + SP + +DG
Sbjct: 669 NLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPG--RWDDGLR 726
Query: 1239 HSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRP 1298
H V L S G Q Q + +++GG L +P
Sbjct: 727 HLVML-----------------SFGPDQLQD---LGQHVHVGG--------RLLAADSQP 758
Query: 1299 LGG-FHGCIHEVRINNELQDFKALP------PQSLG------VSPGCKSCTVCKHGLCRS 1345
GG F GC+ ++R++ F LP P LG ++ GC S +C C +
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFN 818
Query: 1346 -----VEKDSVVCECRPGWTGPLCDQE---ARDPCL 1373
V + C C +TGP C Q+ PCL
Sbjct: 819 GGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCL 854
Score = 47.0 bits (110), Expect = 1e-04
Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 34/142 (23%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVAT----------- 1385
C+H S C C PG++G LC+ + D C C H G+C+
Sbjct: 232 CEHNASCLEGLGSFRCLCWPGYSGELCEVD-EDECASSPCQHGGRCLQRSDPALYGGVQA 290
Query: 1386 ----------GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLC 1434
++C C G+ G C + D C++ C +G H D + C C
Sbjct: 291 AFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE---CASRPCLNGG-HCQDLPNGFQCHC 346
Query: 1435 QPGFSGEHCQQE------NPCL 1450
G++G C+++ +PCL
Sbjct: 347 PDGYAGPTCEEDVDECLSDPCL 368
Score = 42.0 bits (97), Expect = 0.005
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 995 INPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPL 1054
++ D C + C N TC+ N++ C CP N+TG C + + C + C A C +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQ--PCLPPATCEEV 862
Query: 1055 DKGFSC 1060
GF C
Sbjct: 863 PDGFVC 868
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNY 1018
C +PC +GGTC ++ + F C+CP F G C C C ATC + + +
Sbjct: 811 CSPDPCFNGGTCLVT---WNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGF 866
Query: 1019 VCICPPNY 1026
VC+ +
Sbjct: 867 VCVAEATF 874
Score = 40.4 bits (93), Expect = 0.013
Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 8/74 (10%)
Query: 912 NIVAKC---NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGG 968
N+ A C + C PC N GTC + + C CP ++ G C + C PC
Sbjct: 800 NLTAGCVSEDMCSPDPCFNGGTCLVTWND-FHCTCPANFTGPTCAQQL-WCPGQPCLPPA 857
Query: 969 TCHLSDSHKDGFSC 982
TC + DGF C
Sbjct: 858 TC---EEVPDGFVC 868
Score = 35.8 bits (81), Expect = 0.32
Identities = 40/144 (27%), Positives = 50/144 (34%), Gaps = 40/144 (27%)
Query: 1368 ARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQ 1427
A DPC A GT C+ E GG C C+ CHHG +
Sbjct: 43 ASDPC-----------APGTE--CQATES-GGYTCGPMEP--RGCATQPCHHGALCVPQG 86
Query: 1428 GEPY---CLCQPGFSGEHCQQE------NPC-LGQVVREVIRRQK-----GYA------- 1465
+P C C PGF G C+ + PC G R + R + GYA
Sbjct: 87 PDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146
Query: 1466 --SCATASKVPIMECRGGCGPQCC 1487
CA+A + C G G C
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRC 170
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 191 bits (486), Expect = 4e-48
Identities = 92/237 (38%), Positives = 116/237 (48%), Gaps = 14/237 (5%)
Query: 923 SPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSC 982
SPCKN TC+ Y C C Y G DC + ++ C NPC++GG+C +DG+ C
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCK---DQEDGYHC 348
Query: 983 SCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN--NYVCICPPNYTGELCDEVIDHCVP 1040
CP G+ G CE + C D+ C N +C + NY C CPPN+TG C++ +D C
Sbjct: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
Query: 1041 ELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTC 1100
N C + +C+ C C PG++G CE DC + C HG C D NG CTC
Sbjct: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
Query: 1101 PQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT--CRCPPGFAGPRCE 1155
P GFSG CE V C C N A C T C CP GF G RCE
Sbjct: 467 PAGFSGRRCE-----VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 112 bits (280), Expect = 3e-24
Identities = 65/220 (29%), Positives = 99/220 (45%), Gaps = 26/220 (11%)
Query: 942 ACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCE 1001
+C + G+ C PI C+ + G C C C G++G+ C ++C
Sbjct: 207 SCLPGWTGEYCQQPI--CLSGCHEQNGYC------SKPAECLCRPGWQGRLC----NECI 254
Query: 1002 DNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPL-DKGFSC 1060
++ + TC + C C + G CD+ +++C + C++ A C + ++C
Sbjct: 255 PHNGCRHGTCS---TPWQCTCDEGWGGLFCDQDLNYCTHH-SPCKNGATCSNSGQRSYTC 310
Query: 1061 ECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQT 1120
C PGY+G CE + +C ++ CR+G C D +GY C CP G+ G CEH T
Sbjct: 311 TCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEH-------ST 363
Query: 1121 SPCDQYECQNGAQCIVVQQEPT--CRCPPGFAGPRCEKLI 1158
C C NG C Q C CPP F G CEK +
Sbjct: 364 LSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV 403
Score = 75.1 bits (183), Expect = 5e-13
Identities = 58/198 (29%), Positives = 77/198 (38%), Gaps = 66/198 (33%)
Query: 1017 NYVCICPPNYTGE----LCDEVIDH-----CVPELNL----------CQ--------HEA 1049
+Y IC NY G+ LC + DH C P+ NL CQ HE
Sbjct: 170 SYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQ 229
Query: 1050 ----------------------KCIP--------LDKGFSCECVPGYSGKLCETDNDDCV 1079
+CIP + C C G+ G C+ D + C
Sbjct: 230 NGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCT 289
Query: 1080 AHK-CRHGAQCVDT-INGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVV 1137
H C++GA C ++ YTCTC G++G CE L+ S CD C+NG C
Sbjct: 290 HHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE-------LELSECDSNPCRNGGSCKDQ 342
Query: 1138 QQEPTCRCPPGFAGPRCE 1155
+ C CPPG+ G CE
Sbjct: 343 EDGYHCLCPPGYYGLHCE 360
Score = 72.4 bits (176), Expect = 3e-12
Identities = 46/129 (35%), Positives = 60/129 (46%), Gaps = 24/129 (18%)
Query: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHGKCVATGTS 1388
P C S ++G C + C CRPGW G LC++ C+ H C HG C T
Sbjct: 220 PICLSGCHEQNGYCSKPAE----CLCRPGWQGRLCNE-----CIPHNGCRHGTC---STP 267
Query: 1389 YMCKCAEGYGGDLCDNKNDSANACSAFK-CHHG-QCHISDQGEPYCLCQPGFSGEHCQQE 1446
+ C C EG+GG CD N C+ C +G C S Q C C+PG++G C+ E
Sbjct: 268 WQCTCDEGWGGLFCD---QDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324
Query: 1447 ------NPC 1449
NPC
Sbjct: 325 LSECDSNPC 333
Score = 65.9 bits (159), Expect = 3e-10
Identities = 40/134 (29%), Positives = 56/134 (41%), Gaps = 28/134 (20%)
Query: 1332 CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGT- 1387
C C C+HG C + + C C GW G CDQ+ L + HH C T
Sbjct: 250 CNECIPHNGCRHGTCSTPWQ----CTCDEGWGGLFCDQD-----LNYCTHHSPCKNGATC 300
Query: 1388 ------SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGE 1441
SY C C GY G C+ + + C + C +G + +CLC PG+ G
Sbjct: 301 SNSGQRSYTCTCRPGYTGVDCELE---LSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGL 357
Query: 1442 HCQQ------ENPC 1449
HC+ ++PC
Sbjct: 358 HCEHSTLSCADSPC 371
Score = 59.3 bits (142), Expect = 3e-08
Identities = 37/119 (31%), Positives = 53/119 (44%), Gaps = 12/119 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQE----ARDPCLGHRCHHGKCVATGT 1387
C S G C + S +C CRPG+TG C+ AR+PC H G C
Sbjct: 406 CTSNPCANGGQCLN-RGPSRMCRCRPGFTGTYCELHVSDCARNPC----AHGGTCHDLEN 460
Query: 1388 SYMCKCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444
MC C G+ G C+ + S +AC++ C + C+ + + C C GF G C+
Sbjct: 461 GLMCTCPAGFSGRRCEVRT-SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 58.2 bits (139), Expect = 6e-08
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 17/123 (13%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQE----ARDPCL-GHRCHHGKCVATGTSYMCK 1392
C++G ++D C C PG+ G C+ A PC G C G +Y C+
Sbjct: 333 CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERN---QGANYACE 389
Query: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QE 1446
C + G C+ K D C++ C +G ++ C C+PGF+G +C+
Sbjct: 390 CPPNFTGSNCEKKVDR---CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCAR 446
Query: 1447 NPC 1449
NPC
Sbjct: 447 NPC 449
Score = 42.0 bits (97), Expect = 0.005
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 918 NACLSSPCKNNGTCTQD-PVELYRCACPYSYKGKDCTVPI 956
+AC SSPC N TC D + + C CPY + G C P+
Sbjct: 482 DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 191 bits (484), Expect = 6e-48
Identities = 98/306 (32%), Positives = 144/306 (47%), Gaps = 30/306 (9%)
Query: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDINIV 914
P C C + W + + PG + +P +QC +G +
Sbjct: 240 PGECKCRVGWQGRYCDECIRYPGCLHGTCQQP-------------WQCNCQEGWGGLFCN 286
Query: 915 AKCNACLS-SPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
N C PCKN TCT Y C+C Y G C + I+ C +PC++GG+C
Sbjct: 287 QDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC--- 343
Query: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN-YVCICPPNYTGELCD 1032
++ +SC+CP GF G+ CE++ C D C N C D + Y C CP Y+G C+
Sbjct: 344 TDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
Query: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDT 1092
+ ID+C + C + AKC+ L + C C G+SG+ C+ + DDC + C +G C D
Sbjct: 404 KKIDYC--SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
Query: 1093 INGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGP 1152
+N ++CTCP G++G C P S C+ C NGA C C C G+ GP
Sbjct: 462 VNDFSCTCPPGYTGRNCSAP-------VSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514
Query: 1153 RCEKLI 1158
C+ L+
Sbjct: 515 NCQFLL 520
Score = 100 bits (248), Expect = 1e-20
Identities = 51/146 (34%), Positives = 69/146 (47%), Gaps = 7/146 (4%)
Query: 898 TPTHRFQCKGPVD---INIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTV 954
+P + C+ PV N K + C SSPC N C D + Y C C + G+ C
Sbjct: 384 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV-DLGDAYLCRCQAGFSGRHCDD 442
Query: 955 PINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDG 1014
++ C +PC +GGTC D D FSC+CP G+ G+ C CE C N ATC +
Sbjct: 443 NVDDCASSPCANGGTCR--DGVND-FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499
Query: 1015 INNYVCICPPNYTGELCDEVIDHCVP 1040
+ YVC C Y G C ++ P
Sbjct: 500 GHRYVCECARGYGGPNCQFLLPELPP 525
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/117 (35%), Positives = 55/117 (47%), Gaps = 20/117 (17%)
Query: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSY 1389
PGC +HG C + C+CR GW G CD+ R P C HG C +
Sbjct: 228 PGCDE----QHGFCDKPGE----CKCRVGWQGRYCDECIRYP----GCLHGTC---QQPW 272
Query: 1390 MCKCAEGYGGDLCDNKNDSANACSAFK-CHHG-QCHISDQGEPYCLCQPGFSGEHCQ 1444
C C EG+GG C N N C+ K C +G C + QG C C+PG++G C+
Sbjct: 273 QCNCQEGWGGLFC---NQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE 326
Score = 69.7 bits (169), Expect = 2e-11
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 25/165 (15%)
Query: 1332 CKSCTVCKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSY 1389
C CK+G C + + S C CRPG+TG C+ D C C + G C SY
Sbjct: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCEL-GIDECDPSPCKNGGSCTDLENSY 350
Query: 1390 MCKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGEHCQQE-- 1446
C C G+ G +C+ SA C+ C + G+C S G C C G+SG +C+++
Sbjct: 351 SCTCPPGFYGKICEL---SAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID 407
Query: 1447 ----NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCC 1487
+PC A C + C+ G + C
Sbjct: 408 YCSSSPC------------SNGAKCVDLGDAYLCRCQAGFSGRHC 440
Score = 56.6 bits (135), Expect = 2e-07
Identities = 35/114 (30%), Positives = 52/114 (45%), Gaps = 9/114 (7%)
Query: 1334 SCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCK 1392
S + C +G D+ +C C+ G++G CD D C C +G G + + C
Sbjct: 410 SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV-DDCASSPCANGGTCRDGVNDFSCT 468
Query: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPY-CLCQPGFSGEHCQ 1444
C GY G C + + C CH+G CH ++G Y C C G+ G +CQ
Sbjct: 469 CPPGYTGRNC---SAPVSRCEHAPCHNGATCH--ERGHRYVCECARGYGGPNCQ 517
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 187 bits (475), Expect = 7e-47
Identities = 132/441 (29%), Positives = 187/441 (42%), Gaps = 69/441 (15%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKD- 978
C +PC N+GTC Q Y C CP Y G C I+ C PC + G C KD
Sbjct: 1197 CFFNPCHNSGTC-QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC------KDL 1249
Query: 979 --GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
F C CP G+ GQRCE N ++C + C N CVDG+ Y C C + G C+ ++
Sbjct: 1250 VGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVN 1309
Query: 1037 HCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
C + N C + A C GF C+C PG+ G C + D+C++ C++GA C D N +
Sbjct: 1310 EC--QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
Query: 1097 TCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
C C GF+G CE L + C C+N A C+ +C+C PGF+G RCE
Sbjct: 1368 RCLCAAGFTGSHCE-------LNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
Query: 1157 LITVNF------VGKDSYVELAS-------------AKVRPQANISLQVATDKDNGILLY 1197
+ F G YV L K N ++ DN
Sbjct: 1421 EQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDN----- 1475
Query: 1198 KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVEL--VTLNQTLNLVVD 1255
G ++ L L Y G V V + + + +VNDG++H + + + N + +D
Sbjct: 1476 -GSDNTLLLTDYNGWVLYV-----NGREKITNCPSVNDGRWHHIAITWTSANGIWKVYID 1529
Query: 1256 KGTPKSLGKLQKQPA---VGINSPLYLGGIPTSTGLSALRQGTD-RPLGGFHGCIHEVRI 1311
GKL A VG+ P GG G ++G P F G I ++
Sbjct: 1530 -------GKLSDGGAGLSVGLPIP---GGGALVLGQEQDKKGEGFSPAESFVGSISQL-- 1577
Query: 1312 NNELQDFKALPPQSLGVSPGC 1332
L D+ P Q ++ C
Sbjct: 1578 --NLWDYVLSPQQVKSLATSC 1596
Score = 145 bits (365), Expect = 4e-34
Identities = 66/157 (42%), Positives = 87/157 (55%), Gaps = 6/157 (3%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C SSPC N G C D V YRC C + G C +N C NPC + C +
Sbjct: 1271 NECSSSPCLNKGICV-DGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVC---EDQV 1326
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
GF C CP GF G RC N D+C C+N ATC DG N++ C+C +TG C+ I+
Sbjct: 1327 GGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETD 1074
C + N C+++A C+ +SC+C PG+SGK CET+
Sbjct: 1387 C--QSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 124 bits (311), Expect = 7e-28
Identities = 84/270 (31%), Positives = 114/270 (42%), Gaps = 42/270 (15%)
Query: 919 ACLSSPCKNNGTCTQDPVELYRCA--CPYSYKGKDCTVPINTCIQN------------PC 964
+CLS P +N T + V + C CP + +P + C ++ C
Sbjct: 1085 SCLSCP-ENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLAC 1143
Query: 965 QHGGTCHLSDSHK----DGFSCS-----------CPLGFEGQRCEINPD---DCEDNDCE 1006
GT + S FS + LG +R EI+ +C N C
Sbjct: 1144 PFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCH 1203
Query: 1007 NNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGY 1066
N+ TC YVC+CP YTG C+ ID C P C + C L F CEC GY
Sbjct: 1204 NSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP--LPCLNNGVCKDLVGEFICECPSGY 1261
Query: 1067 SGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQY 1126
+G+ CE + ++C + C + CVD + GY CTC +GF G CE + + C
Sbjct: 1262 TGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE-------TEVNECQSN 1314
Query: 1127 ECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
C N A C C+CPPGF G RC K
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGK 1344
Score = 120 bits (300), Expect = 1e-26
Identities = 59/161 (36%), Positives = 86/161 (53%), Gaps = 14/161 (8%)
Query: 878 EPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDINIVAKCNACLSSPCKNNGTCTQD 934
E I CSS P ++ + ++C KG V ++ + N C S+PC NN C +D
Sbjct: 1267 EENINECSS-SPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVC-ED 1324
Query: 935 PVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG---FSCSCPLGFEGQ 991
V + C CP + G C ++ C+ PC++G TC KDG F C C GF G
Sbjct: 1325 QVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC------KDGANSFRCLCAAGFTGS 1378
Query: 992 RCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD 1032
CE+N ++C+ N C N ATCVD +N+Y C C P ++G+ C+
Sbjct: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 67.8 bits (164), Expect = 8e-11
Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYM 1390
C+S + +C + +C+C PG+ G C + D CL C +G C S+
Sbjct: 1311 CQSNPCLNNAVCED-QVGGFLCKCPPGFLGTRCGKNV-DECLSQPCKNGATCKDGANSFR 1368
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
C CA G+ G C+ + N C + C + + + C CQPGFSG+ C+ E
Sbjct: 1369 CLCAAGFTGSHCEL---NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 60.8 bits (146), Expect = 9e-09
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 13/126 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARD----PCLGHRCHHGKCVATGT 1387
C +G+C+ + + +CEC G+TG C++ + PCL + G CV
Sbjct: 1235 CSPLPCLNNGVCKDLVGE-FICECPSGYTGQRCEENINECSSSPCL----NKGICVDGVA 1289
Query: 1388 SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHC-QQE 1446
Y C C +G+ G C+ + N C + C + G C C PGF G C +
Sbjct: 1290 GYRCTCVKGFVGLHCETE---VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV 1346
Query: 1447 NPCLGQ 1452
+ CL Q
Sbjct: 1347 DECLSQ 1352
Score = 59.3 bits (142), Expect = 3e-08
Identities = 44/151 (29%), Positives = 61/151 (40%), Gaps = 39/151 (25%)
Query: 921 LSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGF 980
L S C NGT T P+ R C + PCQ+GG C ++
Sbjct: 3452 LRSVCLENGTWTSPPI--CRAVCRF-----------------PCQNGGICQRPNA----- 3487
Query: 981 SCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVP 1040
CSCP G+ G+ CE + C N CV Y C CPP +TG C H
Sbjct: 3488 -CSCPEGWMGRLCE---EPICILPCLNGGRCVAP---YQCDCPPGWTGSRC-----HTAV 3535
Query: 1041 ELNLCQHEAKCIPLDKGFSCECVPGYSGKLC 1071
+ C + KC+ ++ C C+ ++G C
Sbjct: 3536 CQSPCLNGGKCVRPNR---CHCLSSWTGHNC 3563
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/115 (33%), Positives = 51/115 (44%), Gaps = 19/115 (16%)
Query: 917 CNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSH 976
C A PC+N G C + C+CP + G+ C PI CI PC +GG C
Sbjct: 3468 CRAVCRFPCQNGGICQRPNA----CSCPEGWMGRLCEEPI--CIL-PCLNGGRCVAP--- 3517
Query: 977 KDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
+ C CP G+ G RC + C+ + C N CV C C ++TG C
Sbjct: 3518 ---YQCDCPPGWTGSRC--HTAVCQ-SPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
Score = 48.9 bits (115), Expect = 4e-05
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 12/89 (13%)
Query: 1372 CLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGE 1429
C + CH+ G C G Y+C C GY G C+ D CS C ++G C GE
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDE---CSPLPCLNNGVCK-DLVGE 1252
Query: 1430 PYCLCQPGFSGEHCQQ------ENPCLGQ 1452
C C G++G+ C++ +PCL +
Sbjct: 1253 FICECPSGYTGQRCEENINECSSSPCLNK 1281
Score = 48.1 bits (113), Expect = 6e-05
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 16/76 (21%)
Query: 1083 CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT 1142
C++G C C+CP+G+ G CE P ++ C NG +C+ Q
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPICIL----------PCLNGGRCVAPYQ--- 3519
Query: 1143 CRCPPGFAGPRCEKLI 1158
C CPPG+ G RC +
Sbjct: 3520 CDCPPGWTGSRCHTAV 3535
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 17/105 (16%)
Query: 1005 CENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVP 1064
C+N C C CP + G LC+E I C+ C + +C+ + C+C P
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPI--CILP---CLNGGRCVA---PYQCDCPP 3524
Query: 1065 GYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFC 1109
G++G C T C +G +CV C C ++G C
Sbjct: 3525 GWTGSRCHT---AVCQSPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
Score = 45.4 bits (106), Expect = 4e-04
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 8/82 (9%)
Query: 1328 VSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATG 1386
+S CK+ CK G +S C C G+TG C+ + C + C + CV
Sbjct: 1350 LSQPCKNGATCKDGA------NSFRCLCAAGFTGSHCELNINE-CQSNPCRNQATCVDEL 1402
Query: 1387 TSYMCKCAEGYGGDLCDNKNDS 1408
SY CKC G+ G C+ + +
Sbjct: 1403 NSYSCKCQPGFSGKRCETEQST 1424
Score = 42.4 bits (98), Expect = 0.003
Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 15/94 (15%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANAC 1412
C C GW G LC++ C+ + G+CVA Y C C G+ G C C
Sbjct: 3488 CSCPEGWMGRLCEEPI---CILPCLNGGRCVA---PYQCDCPPGWTGSRCHTA-----VC 3536
Query: 1413 SAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
+ + G+C ++ C C ++G +C ++
Sbjct: 3537 QSPCLNGGKCVRPNR----CHCLSSWTGHNCSRK 3566
Score = 35.8 bits (81), Expect = 0.32
Identities = 13/36 (36%), Positives = 24/36 (66%), Gaps = 1/36 (2%)
Query: 995 INPDDCE-DNDCENNATCVDGINNYVCICPPNYTGE 1029
++ D+C +DC +A+C++ +Y+C C P YTG+
Sbjct: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGD 1779
Score = 32.7 bits (73), Expect = 2.8
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 3/36 (8%)
Query: 1125 QYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITV 1160
++ CQNG C Q+ C CP G+ G CE+ I +
Sbjct: 3473 RFPCQNGGIC---QRPNACSCPEGWMGRLCEEPICI 3505
Score = 32.3 bits (72), Expect = 3.6
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 16/80 (20%)
Query: 1035 IDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAH-KCR--------H 1085
+D C + C A C+ +D + C CVP Y+G D +C KC+ H
Sbjct: 1746 VDECAVGSD-CSEHASCLNVDGSYICSCVPPYTG-----DGKNCAEPIKCKAPGNPENGH 1799
Query: 1086 GAQCVDTING-YTCTCPQGF 1104
+ + T+ T +C +G+
Sbjct: 1800 SSGEIYTVGAEVTFSCQEGY 1819
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 183 bits (464), Expect = 1e-45
Identities = 134/423 (31%), Positives = 207/423 (48%), Gaps = 13/423 (3%)
Query: 34 CPTKCTCSAAS-VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHL 92
CP++CTCS AS V+C G + AVP +P NA L + +IT + + F + L L +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 93 EDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 152
E N++S I GAF++L L L L NKLQVLP LFQ L L LS NQ+ I
Sbjct: 91 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150
Query: 153 FRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRL 212
F +++K LQL NH+ I DGAF L L L L N+++ I F H+ ++ LRL
Sbjct: 151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210
Query: 213 HSNHLYCDCHLAWLSDWLRQRRTV---GQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSE 269
+ N L D + + + Q L + N+ ++ Y+ S+
Sbjct: 211 YENRL-TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL----QRLYLSNNHISQ 265
Query: 270 PPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329
P + + T N + G+ NL E+ L N I ++P F+
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR----ELWLYDNHISSLPDNVFSN 321
Query: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
++L+ + +S+NQIS I+P AF GL L L L+ N + ++ +F L +LQ + L N
Sbjct: 322 LRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN 381
Query: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLA 449
++ L N F ++ L + L +N+L+ + G+F L + L L NP+ CD + L
Sbjct: 382 RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLR 441
Query: 450 DYL 452
++L
Sbjct: 442 NWL 444
Score = 120 bits (300), Expect = 1e-26
Identities = 119/469 (25%), Positives = 192/469 (40%), Gaps = 105/469 (22%)
Query: 505 CPEKCRCE-GTIVDCSNQKLVRIPSHLP----------EYVTDL--------------RL 539
CP +C C + V+C+ ++V +P+ LP ++T+L R+
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 540 NDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGR 599
NE+S + G F+ L +LR ++L+NNK++ + G F G S++ L+L+ NQL +
Sbjct: 91 EKNELSRI-TPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 600 VFRGLSGLKTLMLRSN------------LIGC------------VSNDTFAGLSSVRLLS 635
F S LK L L N L+G +S F L ++++L
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209
Query: 636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFF 695
LY+NR+T I G F LV+L + L N + +R +S N Q P
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP-- 267
Query: 696 LKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVT 755
I +Q + T GN L P MP ++
Sbjct: 268 -PSIFMQLPQLNRLTLFGNSLKELSLGIFGP-----------------------MP-NLR 302
Query: 756 ELYLEGNHLTAVPREL-SALRHLTLIDLSNNSISMLTNYTFSN----------------- 797
EL+L NH++++P + S LR L ++ LS N IS ++ F+
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 798 -------MSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLS 850
+++L + L NRLR +P + F + L + L N + ++P G F+ L L
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 422
Query: 851 HLALGTNPLHCDCSLRWLSEWVKAGYKEPG---IARCSSPEPMADRLLL 896
L L NP CD + L W+ G + C SP + + L+
Sbjct: 423 ELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 471
Score = 94.4 bits (233), Expect = 8e-19
Identities = 54/189 (28%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 65 RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
RL L N++ ++ F + NLR L L DN +S + F +L+QL+ L L++N++ +
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 338
Query: 125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLE 184
F +L L L N +Q + FR + +++N+ L NN + + F + L
Sbjct: 339 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 398
Query: 185 ILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWL---RQRRTVGQFTL 241
+ L NN + + + F+H+ K+ LRL+ N CD + L +WL + R +
Sbjct: 399 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 458
Query: 242 CMAPVHLRG 250
C +P ++RG
Sbjct: 459 CFSPANVRG 467
Score = 88.6 bits (218), Expect = 4e-17
Identities = 84/306 (27%), Positives = 133/306 (43%), Gaps = 60/306 (19%)
Query: 311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
E++L N ++ IP GAF L ++++ KN ++ I+P FQ L +L L LY N++T+I
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
Query: 371 AKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNL------------------------N 406
G FDGLV+LQ L L N+I L F + NL N
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278
Query: 407 LLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSS 466
L+L+ N L+ +S G+F P+ +++ L L N H+ L D + N R
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDN------HISSLPDNVFSN------LRQLQ 326
Query: 467 PRRLANKRISQIKSKKFRCSGSEDYRS-RFSSECFMDLVCPEKCRCEGTIVDCSNQKLVR 525
L+ +IS I F +G + R + DL + + R
Sbjct: 327 VLILSRNQISFISPGAF--NGLTELRELSLHTNALQDL----------------DGNVFR 368
Query: 526 IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQE 585
+ ++L ++ L +N + L IF + L I L NN+++ + G FD + E
Sbjct: 369 MLANL----QNISLQNNRLRQLPG-NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 423
Query: 586 LMLTGN 591
L L N
Sbjct: 424 LRLYDN 429
Score = 70.1 bits (170), Expect = 2e-11
Identities = 109/470 (23%), Positives = 180/470 (38%), Gaps = 103/470 (21%)
Query: 364 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLF 423
G +I + L +SLQ+L + ++N + F ++ L L + N+L I+ G F
Sbjct: 47 GARIVAVPTPLPWNAMSLQILNTHITELN---ESPFLNISALIALRIEKNELSRITPGAF 103
Query: 424 APLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET-SGARCSSPRRLANKRISQIKSKK 482
L S++ L LA N LQ PI G L++ ++ QI+
Sbjct: 104 RNLGSLRYLSLANNK-------------LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150
Query: 483 FRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD------ 536
F CSN K +++ + EY+ D
Sbjct: 151 FS--------------------------------QCSNLKELQLHGNHLEYIPDGAFDHL 178
Query: 537 -----LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 591
L L N ++ + +F+ L NL+ + L N++ ++ G FDG ++QEL L N
Sbjct: 179 VGLTKLNLGKNSLTHISPR-VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 237
Query: 592 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 651
Q+ + +F L+ L L +N I + F L + L+L+ N + ++ G F
Sbjct: 238 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 297
Query: 652 LVSLSTINLLSN-----PFNCNCHLAWLGKWLRKRRIVSG-NPRCQKPFF-LKEIPIQDV 704
+ +L + L N P N +L L + R +S +P L+E+ +
Sbjct: 298 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 357
Query: 705 AIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHL 764
A+QD DGN V R M ++ + L+ N L
Sbjct: 358 ALQDL--DGN--------------------VFR------------MLANLQNISLQNNRL 383
Query: 765 TAVPRELSA-LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRC 813
+P + A + L I L NN + L F ++ L L L N RC
Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 433
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 183 bits (464), Expect = 1e-45
Identities = 134/423 (31%), Positives = 207/423 (48%), Gaps = 13/423 (3%)
Query: 34 CPTKCTCSAAS-VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHL 92
CP++CTCS AS V+C G + AVP +P NA L + +IT + + F + L L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 93 EDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 152
E N++S I GAF++L L L L NKLQVLP LFQ L L LS NQ+ I
Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 153 FRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRL 212
F +++K LQL NH+ I DGAF L L L L N+++ I F H+ ++ LRL
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 213 HSNHLYCDCHLAWLSDWLRQRRTV---GQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSE 269
+ N L D + + + Q L + N+ ++ Y+ S+
Sbjct: 205 YENRL-TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL----QRLYLSNNHISQ 259
Query: 270 PPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329
P + + T N + G+ NL E+ L N I ++P F+
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR----ELWLYDNHISSLPDNVFSN 315
Query: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
++L+ + +S+NQIS I+P AF GL L L L+ N + ++ +F L +LQ + L N
Sbjct: 316 LRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN 375
Query: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLA 449
++ L N F ++ L + L +N+L+ + G+F L + L L NP+ CD + L
Sbjct: 376 RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLR 435
Query: 450 DYL 452
++L
Sbjct: 436 NWL 438
Score = 120 bits (300), Expect = 1e-26
Identities = 119/469 (25%), Positives = 192/469 (40%), Gaps = 105/469 (22%)
Query: 505 CPEKCRCE-GTIVDCSNQKLVRIPSHLP----------EYVTDL--------------RL 539
CP +C C + V+C+ ++V +P+ LP ++T+L R+
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 540 NDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGR 599
NE+S + G F+ L +LR ++L+NNK++ + G F G S++ L+L+ NQL +
Sbjct: 85 EKNELSRI-TPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 600 VFRGLSGLKTLMLRSN------------LIGC------------VSNDTFAGLSSVRLLS 635
F S LK L L N L+G +S F L ++++L
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
Query: 636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFF 695
LY+NR+T I G F LV+L + L N + +R +S N Q P
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP-- 261
Query: 696 LKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVT 755
I +Q + T GN L P MP ++
Sbjct: 262 -PSIFMQLPQLNRLTLFGNSLKELSLGIFGP-----------------------MP-NLR 296
Query: 756 ELYLEGNHLTAVPREL-SALRHLTLIDLSNNSISMLTNYTFSN----------------- 797
EL+L NH++++P + S LR L ++ LS N IS ++ F+
Sbjct: 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Query: 798 -------MSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLS 850
+++L + L NRLR +P + F + L + L N + ++P G F+ L L
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 416
Query: 851 HLALGTNPLHCDCSLRWLSEWVKAGYKEPG---IARCSSPEPMADRLLL 896
L L NP CD + L W+ G + C SP + + L+
Sbjct: 417 ELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 465
Score = 94.4 bits (233), Expect = 8e-19
Identities = 54/189 (28%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 65 RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
RL L N++ ++ F + NLR L L DN +S + F +L+QL+ L L++N++ +
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
Query: 125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLE 184
F +L L L N +Q + FR + +++N+ L NN + + F + L
Sbjct: 333 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 392
Query: 185 ILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWL---RQRRTVGQFTL 241
+ L NN + + + F+H+ K+ LRL+ N CD + L +WL + R +
Sbjct: 393 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 452
Query: 242 CMAPVHLRG 250
C +P ++RG
Sbjct: 453 CFSPANVRG 461
Score = 88.6 bits (218), Expect = 4e-17
Identities = 84/306 (27%), Positives = 133/306 (43%), Gaps = 60/306 (19%)
Query: 311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
E++L N ++ IP GAF L ++++ KN ++ I+P FQ L +L L LY N++T+I
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
Query: 371 AKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNL------------------------N 406
G FDGLV+LQ L L N+I L F + NL N
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272
Query: 407 LLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSS 466
L+L+ N L+ +S G+F P+ +++ L L N H+ L D + N R
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDN------HISSLPDNVFSN------LRQLQ 320
Query: 467 PRRLANKRISQIKSKKFRCSGSEDYRS-RFSSECFMDLVCPEKCRCEGTIVDCSNQKLVR 525
L+ +IS I F +G + R + DL + + R
Sbjct: 321 VLILSRNQISFISPGAF--NGLTELRELSLHTNALQDL----------------DGNVFR 362
Query: 526 IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQE 585
+ ++L ++ L +N + L IF + L I L NN+++ + G FD + E
Sbjct: 363 MLANL----QNISLQNNRLRQLPG-NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
Query: 586 LMLTGN 591
L L N
Sbjct: 418 LRLYDN 423
Score = 70.1 bits (170), Expect = 2e-11
Identities = 109/470 (23%), Positives = 180/470 (38%), Gaps = 103/470 (21%)
Query: 364 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLF 423
G +I + L +SLQ+L + ++N + F ++ L L + N+L I+ G F
Sbjct: 41 GARIVAVPTPLPWNAMSLQILNTHITELN---ESPFLNISALIALRIEKNELSRITPGAF 97
Query: 424 APLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET-SGARCSSPRRLANKRISQIKSKK 482
L S++ L LA N LQ PI G L++ ++ QI+
Sbjct: 98 RNLGSLRYLSLANNK-------------LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 483 FRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD------ 536
F CSN K +++ + EY+ D
Sbjct: 145 FS--------------------------------QCSNLKELQLHGNHLEYIPDGAFDHL 172
Query: 537 -----LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 591
L L N ++ + +F+ L NL+ + L N++ ++ G FDG ++QEL L N
Sbjct: 173 VGLTKLNLGKNSLTHISPR-VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 231
Query: 592 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 651
Q+ + +F L+ L L +N I + F L + L+L+ N + ++ G F
Sbjct: 232 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 291
Query: 652 LVSLSTINLLSN-----PFNCNCHLAWLGKWLRKRRIVSG-NPRCQKPFF-LKEIPIQDV 704
+ +L + L N P N +L L + R +S +P L+E+ +
Sbjct: 292 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 351
Query: 705 AIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHL 764
A+QD DGN V R M ++ + L+ N L
Sbjct: 352 ALQDL--DGN--------------------VFR------------MLANLQNISLQNNRL 377
Query: 765 TAVPRELSA-LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRC 813
+P + A + L I L NN + L F ++ L L L N RC
Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 427
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 181 bits (460), Expect = 4e-45
Identities = 93/244 (38%), Positives = 124/244 (50%), Gaps = 21/244 (8%)
Query: 918 NACLSSPCKNNGTCT-----QDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHL 972
+AC PC+NN +C QD + C C Y G+ C I+ CI +PC++G TC
Sbjct: 351 DACQRKPCQNNASCIDANEKQDGSN-FTCVCLPGYTGELCQSKIDYCILDPCRNGATCIS 409
Query: 973 SDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATC-VDGINNYVCICPPNYTGELC 1031
S S GF+C CP G+ G CE D C + C+NN TC VDG+ ++ C C P +TG C
Sbjct: 410 SLS---GFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTC 465
Query: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
++ID C L+ C H C + + C C PGY G CE + ++C++ C + A C D
Sbjct: 466 AQLIDFCA--LSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRD 522
Query: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
+NGY C C + G CE L PC C NGA C TC C PGF G
Sbjct: 523 LVNGYECVCLAEYKGTHCE-------LYKDPCANVSCLNGATCDSDGLNGTCICAPGFTG 575
Query: 1152 PRCE 1155
C+
Sbjct: 576 EECD 579
Score = 149 bits (376), Expect = 2e-35
Identities = 73/195 (37%), Positives = 99/195 (50%), Gaps = 7/195 (3%)
Query: 916 KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS 975
K + C SSPC+NNGTC D V + C C + G C I+ C +PC HG + S
Sbjct: 430 KVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTS 488
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
+K C C G+ G CE ++C C N ATC D +N Y C+C Y G C+
Sbjct: 489 YK----CLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK 544
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
D C C + A C +C C PG++G+ C+ D ++C ++ C HG C+D NG
Sbjct: 545 DPCANVS--CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
Query: 1096 YTCTCPQGFSGPFCE 1110
Y C CP G+ G CE
Sbjct: 603 YNCHCPHGWVGANCE 617
Score = 134 bits (336), Expect = 9e-31
Identities = 76/216 (35%), Positives = 106/216 (49%), Gaps = 26/216 (12%)
Query: 954 VPINTCIQNP-------CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCE 1006
V ++TC+ C G C S FSC+C + G CE D C+ C+
Sbjct: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEAT-FSCTCEEQYVGTFCE-EYDACQRKPCQ 359
Query: 1007 NNATCVDGI-----NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCE 1061
NNA+C+D +N+ C+C P YTGELC ID+C+ L+ C++ A CI GF+C+
Sbjct: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCI--LDPCRNGATCISSLSGFTCQ 417
Query: 1062 CVPGYSGKLCETDNDDCVAHKCRHGAQC-VDTINGYTCTCPQGFSGPFCEHPPPMVLLQT 1120
C GY G CE D C + C++ C VD ++ +TC C GF+GP C L
Sbjct: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCAL-- 474
Query: 1121 SPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
SPC C++ V C C PG+ G CE+
Sbjct: 475 SPCAHGTCRS------VGTSYKCLCDPGYHGLYCEE 504
Score = 125 bits (314), Expect = 3e-28
Identities = 60/173 (34%), Positives = 85/173 (49%), Gaps = 17/173 (9%)
Query: 993 CEINPDDCEDNDCENNATCVDGINN--YVCICPPNYTGELCDEVIDHCVPELNLCQHEAK 1050
C D +C C + + C C Y G C+E D C + CQ+ A
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DAC--QRKPCQNNAS 363
Query: 1051 CIPLDK-----GFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFS 1105
CI ++ F+C C+PGY+G+LC++ D C+ CR+GA C+ +++G+TC CP+G+
Sbjct: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
Query: 1106 GPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
G CE + PC CQN C V TC C PGF GP C +LI
Sbjct: 424 GSACEE-------KVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
Score = 78.6 bits (192), Expect = 4e-14
Identities = 89/417 (21%), Positives = 144/417 (34%), Gaps = 79/417 (18%)
Query: 1055 DKGFSCECVPGYSGKLCETDNDDCVAHKCRHG---AQCVDTINGYTCTCPQGFSGPFCEH 1111
+ G+SC C G SG C+ D C ++ C HG + + +GY C C +G+ GP CE
Sbjct: 75 EPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Query: 1112 PPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVEL 1171
P L + + Q + QEP P
Sbjct: 135 ALPS--LPATGWTESMAPRQLQPVPATQEPDKILP------------------------- 167
Query: 1172 ASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVE 1231
R QA ++L K Q V + +D + P
Sbjct: 168 -----RSQATVTLPTWQPKTG-----------------QKVVEMKWDQVEVIPDIACGNA 205
Query: 1232 TVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGG-----IPTST 1286
+ N + + Q ++ + + SL L K A G + G + S
Sbjct: 206 SSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASG 265
Query: 1287 GLSALRQGTDRPLGGFHGCIHE--------VRINNELQDFKALPPQSLGVSPGCKSCTVC 1338
GL L + F G +++ +R+ ++ +P +S C
Sbjct: 266 GLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSG---- 321
Query: 1339 KHGLCRSVEKDSVV-CECRPGWTGPLCDQE---ARDPCLGH-RCHHGKCVATGTSYMCKC 1393
G C + ++ C C + G C++ R PC + C G+++ C C
Sbjct: 322 -KGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVC 380
Query: 1394 AEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
GY G+LC +K D C C +G IS C C G+ G C+++ +PC
Sbjct: 381 LPGYTGELCQSKID---YCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
Score = 72.8 bits (177), Expect = 2e-12
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEG 1396
C++G C+C G+ G C+++ DPC C ++G C G + C C+ G
Sbjct: 401 CRNGATCISSLSGFTCQCPEGYFGSACEEKV-DPCASSPCQNNGTCYVDGVHFTCNCSPG 459
Query: 1397 YGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQE-NPCL 1450
+ G C D C+ C HG C G Y CLC PG+ G +C++E N CL
Sbjct: 460 FTGPTCAQLID---FCALSPCAHGTCR--SVGTSYKCLCDPGYHGLYCEEEYNECL 510
Score = 71.6 bits (174), Expect = 5e-12
Identities = 36/112 (32%), Positives = 45/112 (40%), Gaps = 11/112 (9%)
Query: 894 LLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDP-----------VELYRCA 942
LLL PV ++ C + PC+N G CT P Y C
Sbjct: 22 LLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT 81
Query: 943 CPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCE 994
CP G +C + + C NPC HG S S DG+ C C G+EG CE
Sbjct: 82 CPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 69.3 bits (168), Expect = 3e-11
Identities = 48/159 (30%), Positives = 60/159 (37%), Gaps = 43/159 (27%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
C S +G C V+ C C PG+TGP C Q D C C HG C + GTSY C
Sbjct: 434 CASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQLI-DFCALSPCAHGTCRSVGTSYKC 491
Query: 1392 KCAEGYGGDLCDNK-NDSANA----------------------------------CSAFK 1416
C GY G C+ + N+ +A C+
Sbjct: 492 LCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVS 551
Query: 1417 CHHGQCHISDQGEPYCLCQPGFSGEHCQ------QENPC 1449
C +G SD C+C PGF+GE C NPC
Sbjct: 552 CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC 590
Score = 68.6 bits (166), Expect = 5e-11
Identities = 36/95 (37%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
C C PG+TG LC Q D C+ C +G C+++ + + C+C EGY G C+ K D
Sbjct: 378 CVCLPGYTGELC-QSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD---P 433
Query: 1412 CSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
C++ C ++G C++ D C C PGF+G C Q
Sbjct: 434 CASSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQ 467
Score = 68.2 bits (165), Expect = 6e-11
Identities = 29/77 (37%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C + C N TC D + C C + G++C + IN C NPC HGG+C +G
Sbjct: 547 CANVSCLNGATCDSDGLN-GTCICAPGFTGEECDIDINECDSNPCHHGGSCL---DQPNG 602
Query: 980 FSCSCPLGFEGQRCEIN 996
++C CP G+ G CEI+
Sbjct: 603 YNCHCPHGWVGANCEIH 619
Score = 62.8 bits (151), Expect = 2e-09
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 12/89 (13%)
Query: 959 CIQNPCQHGGTC---------HLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCEN-- 1007
C PC++GG C H + + + G+SC+CP G G C++ D C N C +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 1008 -NATCVDGINNYVCICPPNYTGELCDEVI 1035
+++ + Y+CIC Y G C++ +
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 60.1 bits (144), Expect = 2e-08
Identities = 46/169 (27%), Positives = 61/169 (36%), Gaps = 56/169 (33%)
Query: 1314 ELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEA----- 1368
+L DF AL P C HG CRSV S C C PG+ G C++E
Sbjct: 467 QLIDFCALSP--------------CAHGTCRSVGT-SYKCLCDPGYHGLYCEEEYNECLS 511
Query: 1369 --------------------------------RDPCLGHRCHHGK-CVATGTSYMCKCAE 1395
+DPC C +G C + G + C CA
Sbjct: 512 APCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAP 571
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
G+ G+ CD N C + CHHG + C C G+ G +C+
Sbjct: 572 GFTGEECDI---DINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 48.5 bits (114), Expect = 5e-05
Identities = 29/105 (27%), Positives = 37/105 (35%), Gaps = 19/105 (18%)
Query: 1362 PLCDQEARDPCLGHRCHHG-------------KCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
P A PC C +G A Y C C G G C
Sbjct: 38 PAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLV--- 94
Query: 1409 ANACSAFKCHHGQCHISDQGEP---YCLCQPGFSGEHCQQENPCL 1450
A+ C++ CHHG C S C+C G+ G +C+Q P L
Sbjct: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSL 139
Score = 42.0 bits (97), Expect = 0.005
Identities = 26/91 (28%), Positives = 29/91 (31%), Gaps = 17/91 (18%)
Query: 997 PDDCEDNDCENNATCVD------------GINNYVCICPPNYTGELCDEVIDHCVPELNL 1044
P C C N C G Y C CP +G C V D C N
Sbjct: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS--NP 102
Query: 1045 CQH---EAKCIPLDKGFSCECVPGYSGKLCE 1072
C H + G+ C C GY G CE
Sbjct: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 40.0 bits (92), Expect = 0.017
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 32/153 (20%)
Query: 1380 GKCVA--TGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHI-----SDQGEPYC 1432
GKC + ++ C C E Y G C + +AC C + I D C
Sbjct: 323 GKCTTKPSEATFSCTCEEQYVGTFC----EEYDACQRKPCQNNASCIDANEKQDGSNFTC 378
Query: 1433 LCQPGFSGEHCQQE------NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQC 1486
+C PG++GE CQ + +PC + A+C ++ +C G
Sbjct: 379 VCLPGYTGELCQSKIDYCILDPC------------RNGATCISSLSGFTCQCPEGYFGSA 426
Query: 1487 CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
C+ Q +G+ +V+ V H C C
Sbjct: 427 CEEKVDPCASSPCQ-NNGTCYVDGV--HFTCNC 456
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 175 bits (443), Expect = 3e-43
Identities = 110/351 (31%), Positives = 153/351 (43%), Gaps = 43/351 (12%)
Query: 809 NRLRCIPVHAFNGLRSLRVLTLHGNDISSVP---EGSFNDLTSLSHLALGTNPLHCDCSL 865
N RCI F+G + + N+ SS P G+ DLT N C+C
Sbjct: 910 NNFRCICRPGFSG----SLCEIEINECSSEPCKNNGTCVDLT---------NRFFCNCEP 956
Query: 866 RWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDINIVAKCNACLS 922
+ + + + I+ C E R T + C G IN + CLS
Sbjct: 957 EYHGPFCELDVNKCKISPCLDEENCVYR------TDGYNCLCAPGYTGINCEINLDECLS 1010
Query: 923 SPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSC 982
PC ++G C D + Y C C + G C N C+ NPC HG L + + C
Sbjct: 1011 EPCLHDGVCI-DGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINE----YPC 1065
Query: 983 SCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV-PE 1041
SC +C+I +DC C N C + + CICP YTG C++ ID+C PE
Sbjct: 1066 SCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPE 1125
Query: 1042 LN--LCQHEAKCIP-LDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
LN +C + C+ F C C+PG+SG+ CE + ++C + C HGA C D INGY C
Sbjct: 1126 LNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVC 1185
Query: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGF 1149
C G+SG CE+ C C + C+ + TC C PGF
Sbjct: 1186 KCQPGWSGHHCEN--------ELECIPNSCVH-ELCMENEPGSTCLCTPGF 1227
Score = 173 bits (438), Expect = 1e-42
Identities = 90/273 (32%), Positives = 121/273 (44%), Gaps = 37/273 (13%)
Query: 918 NAC--LSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS 975
N C L +PC+NN TC C C ++GK+C + + C+ CQ G C +
Sbjct: 851 NLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDC---ED 907
Query: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
+ F C C GF G CEI ++C C+NN TCVD N + C C P Y G C+ +
Sbjct: 908 MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDV 967
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
+ C +++ C E C+ G++C C PGY+G CE + D+C++ C H C+D IN
Sbjct: 968 NKC--KISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH 1025
Query: 1096 YTCTCPQGFSGPFCE------------HPPPMVLLQTSPCD------------------Q 1125
YTC C GF G CE H L+ PC
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTS 1085
Query: 1126 YECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
C N C TC CP G+ G CEK I
Sbjct: 1086 IPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSI 1118
Score = 157 bits (396), Expect = 1e-37
Identities = 82/244 (33%), Positives = 115/244 (47%), Gaps = 20/244 (8%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S PCKNNGTC D + C C Y G C + +N C +PC C
Sbjct: 930 NECSSEPCKNNGTCV-DLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVY---RT 985
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
DG++C C G+ G CEIN D+C C ++ C+DGIN+Y C C + G C+ +
Sbjct: 986 DGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNAND 1045
Query: 1038 CVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYT 1097
C+ N C H +C L + C C + C+ +DC + C + C + +G+T
Sbjct: 1046 CLS--NPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFT 1102
Query: 1098 CTCPQGFSGPFCEHPPPMVLLQTSPCDQYE-----CQNGAQCIVVQQEP-TCRCPPGFAG 1151
C CP+G++G +CE C + E C NG C+ CRC PGF+G
Sbjct: 1103 CICPRGYTGAYCEK-------SIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSG 1155
Query: 1152 PRCE 1155
CE
Sbjct: 1156 QFCE 1159
Score = 152 bits (384), Expect = 2e-36
Identities = 94/316 (29%), Positives = 145/316 (45%), Gaps = 30/316 (9%)
Query: 857 NPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKG--PVDINIV 914
N C CSL ++ + C ++ L +H C G + NI
Sbjct: 586 NRPRCSCSLSYIGRLCVVN-----VDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNIC 640
Query: 915 A-KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
C S+ CKN T T +R P +KG C + I+ C +PC++G TC
Sbjct: 641 EIDTEDCKSASCKNGTTSTHLRGYFFRKCVP-GFKGTQCEIDIDECASHPCKNGATCIDQ 699
Query: 974 DSHK-----------DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCIC 1022
+ DGFSC C G+ G RCE + DDC N CE+N+TC D +Y C+C
Sbjct: 700 PGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVC 759
Query: 1023 PPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHK 1082
++ G C++ + C ++N C++ + C L K + CEC G++G+ C + ++C +
Sbjct: 760 LSDWEGNFCEQESNEC--KMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP 817
Query: 1083 CRHGAQCVD-TING-YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCI-VVQQ 1139
C +G C + TI G + C CP ++G FC + L +P C+N + C+ +V
Sbjct: 818 CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNP-----CRNNSTCLALVDA 872
Query: 1140 EPTCRCPPGFAGPRCE 1155
C C F G CE
Sbjct: 873 NQHCICREEFEGKNCE 888
Score = 130 bits (327), Expect = 1e-29
Identities = 76/251 (30%), Positives = 113/251 (45%), Gaps = 32/251 (12%)
Query: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH---LSDSHKDGFS 981
C++ C +D + RC+C SY G+ C V ++ C+ N H + H L+ SH +
Sbjct: 575 CQHEAVC-KDEINRPRCSCSLSYIGRLCVVNVDYCLGN---HSISVHGLCLALSHN--CN 628
Query: 982 CSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPE 1041
CS +E CEI+ +DC+ C+N T + C P + G C+ ID C
Sbjct: 629 CSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECAS- 687
Query: 1042 LNLCQHEAKCIP--------------LDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGA 1087
+ C++ A CI + GFSC C PGY G CE D DDC+ + C H +
Sbjct: 688 -HPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNS 746
Query: 1088 QCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPP 1147
C D Y C C + G FCE +++ C C+N + C + + C C
Sbjct: 747 TCKDLHLSYQCVCLSDWEGNFCEQ-------ESNECKMNPCKNNSTCTDLYKSYRCECTS 799
Query: 1148 GFAGPRCEKLI 1158
G+ G C + I
Sbjct: 800 GWTGQNCSEEI 810
Score = 124 bits (311), Expect = 7e-28
Identities = 103/365 (28%), Positives = 159/365 (43%), Gaps = 52/365 (14%)
Query: 1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFC---------EHPPPMVLLQTSPCDQYEC 1128
C KC +G C+++ C C G+ G FC EH PP + C
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP-----------HHC 2662
Query: 1129 QNGAQCIVVQQEPTCRCPPGFAGPRCEKLITV---NFVGKD-SYVELASAKVRPQANISL 1184
GA CI + TC CP G G CE+ +++ +F + S++ AS VR + +I L
Sbjct: 2663 SRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQL 2722
Query: 1185 QVATDKDNGILLYKGDN------DPLALELYQGHVRLVYDSLSSPPTTVYSVE--TVNDG 1236
Q +GIL Y + D L + L V+L Y +L + +++ T+N
Sbjct: 2723 QFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRY-NLGDRTIILETLQKVTINGS 2781
Query: 1237 QFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTD 1296
+H ++ + L +D G + K ++ N+ Y+GG+ +S L +
Sbjct: 2782 TWHIIKAGRVGAEGYLDLD-GINVTEKASTKMSSLDTNTDFYIGGV-SSLNLVNPMAIEN 2839
Query: 1297 RPLGGFHGCIHEVRINN---ELQDFKALPPQSLGVSPGCKSCTVCKHGLCR-----SVEK 1348
P+ GF GCI +V INN +L +F A ++G G T C + CR +V
Sbjct: 2840 EPV-GFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDG----TACGYNTCRNGGECTVNG 2894
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGT-SYMCKCAEGYGGDLCDNKN 1406
+ C C P W G C+Q CL + C H C+ + SY C C G+ G C+NK
Sbjct: 2895 TTFSCRCLPDWAGNTCNQSV--SCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKT 2952
Query: 1407 DSANA 1411
+ A
Sbjct: 2953 SFSTA 2957
Score = 107 bits (266), Expect = 1e-22
Identities = 70/267 (26%), Positives = 110/267 (41%), Gaps = 40/267 (14%)
Query: 904 QCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP 963
+C+G +D N C + T DP E +C + ++G +
Sbjct: 492 KCQGVIDAYFFLAAN------CTEDATYVNDP-EDNNSSCWFPHEGT----------KEI 534
Query: 964 CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICP 1023
C +G +C LS+ + C L + G N D ++N+C++ A C D IN C C
Sbjct: 535 CANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCS 593
Query: 1024 PNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKC 1083
+Y G LC +D+C+ ++ H C+ L +C + Y +CE D +DC + C
Sbjct: 594 LSYIGRLCVVNVDYCLGNHSISVH-GLCLALSHNCNCSGLQRYERNICEIDTEDCKSASC 652
Query: 1084 RHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCI-------- 1135
++G + C GF G CE + C + C+NGA CI
Sbjct: 653 KNGTTSTHLRGYFFRKCVPGFKGTQCE-------IDIDECASHPCKNGATCIDQPGNYFC 705
Query: 1136 ------VVQQEPTCRCPPGFAGPRCEK 1156
V +C C PG+ G RCE+
Sbjct: 706 QCVPPFKVVDGFSCLCNPGYVGIRCEQ 732
Score = 100 bits (248), Expect = 1e-20
Identities = 56/215 (26%), Positives = 88/215 (40%), Gaps = 9/215 (4%)
Query: 900 THRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQD----PVELYRCACPYSYKGKDCTVP 955
T+ C+ P + +AC PCKNNG+C + Y C C + GK+C+
Sbjct: 197 TYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Query: 956 INTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGI 1015
I C + C HG +++ + F C C F G CE++ C C +
Sbjct: 257 IGQCQPHVCFHGNCSNITSN---SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS 313
Query: 1016 NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN 1075
+ Y CP + + + + L CQ+ CI + C C P ++ LC++
Sbjct: 314 SAYTYECPKGSSSQNGETDVSEF--SLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
Query: 1076 DDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
C + R+ A C Y C+C GF+ CE
Sbjct: 372 TSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
Score = 98.2 bits (243), Expect = 5e-20
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 54/238 (22%)
Query: 964 CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN-----Y 1018
C G C LS++ +SC C F G+ C+ D C C+NN +C++ N Y
Sbjct: 183 CSGHGKC-LSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAY 240
Query: 1019 VCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDC 1078
C+C P +TG+ C E+I C P ++C H F CEC +SG CE C
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQP--HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
Query: 1079 VAH--------------------------------------KCRHGAQCVDTINGYTCTC 1100
V+ C++G C+ N C C
Sbjct: 299 VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
Query: 1101 PQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
F+ C+ +QTS C+ + +N A C +++ C C GF CEK I
Sbjct: 359 SPIFTDLLCKS------IQTS-CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/365 (26%), Positives = 141/365 (38%), Gaps = 53/365 (14%)
Query: 1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVV 1137
C H CR+ C+ C CP+ +SG C Q + C+ C NGA C+
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC---------QFASCENNPCGNGATCVPK 2389
Query: 1138 Q-QEPTCRCPPGFAGPRCEKLITV---NFVGKD--------SYVELASAKVRPQANISLQ 1185
+ C CP G +GP C I + F G D +Y ++ + ++ Q
Sbjct: 2390 SGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQ 2449
Query: 1186 VATDK---DNGILLYKGD-------NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVND 1235
+A + N ++ + G +D LA+ L G V Y +L S ++ S
Sbjct: 2450 LANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSY-NLGSGIASIRSEPLNLS 2508
Query: 1236 GQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGT 1295
H+V L Q L VD KS+ + + + S Y+GG T L G
Sbjct: 2509 LGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTP-DLLPNGA 2567
Query: 1296 DRPLGGFHGCIHEVRINNELQ-DFKAL-PPQ---SLGVSPG---CKSCTV--CKHGLCRS 1345
D GF GCI +++ E F+ L P+ + G S G C++ C +G
Sbjct: 2568 DFK-NGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCI 2626
Query: 1346 VEKDSVVCECRPGWTGPLCDQEA------RDPCLGHRCHHG-KCVATGTSYMCKCAEGYG 1398
SV C C GW G C + DP H C G C++ Y C C G
Sbjct: 2627 ESGTSVYCNCTTGWKGSFCTETVSTCDPEHDP--PHHCSRGATCISLPHGYTCFCPLGTT 2684
Query: 1399 GDLCD 1403
G C+
Sbjct: 2685 GIYCE 2689
Score = 82.0 bits (201), Expect = 4e-15
Identities = 59/218 (27%), Positives = 83/218 (38%), Gaps = 46/218 (21%)
Query: 984 CPLGFEGQRCEINPDDCEDN----DCENNATCVDGI--NNYVCICPPNYTGELCDEVIDH 1037
CPLG + C+++ C + C+ Y C C P ++G+ C E +D
Sbjct: 159 CPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDA 216
Query: 1038 CVPELNLCQHEAKCIPL-----DKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDT 1092
C C++ CI ++ + C C P ++GK C C H C HG T
Sbjct: 217 C--SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
Query: 1093 INGYTCTCPQGFSGPFCE-HPPPMVLL---------QTSPCDQYE--------------- 1127
N + C C + FSGPFCE P V L +S YE
Sbjct: 275 SNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS 334
Query: 1128 ------CQNGAQCIVVQQEPTCRCPPGFAGPRCEKLIT 1159
CQNG CI + + C C P F C+ + T
Sbjct: 335 EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQT 372
Score = 71.6 bits (174), Expect = 5e-12
Identities = 87/326 (26%), Positives = 135/326 (41%), Gaps = 63/326 (19%)
Query: 1121 SPCDQYECQNGAQCIVVQQEP-----TCRCPPGFAGPRCEK---LITVNFVGKDSYVELA 1172
S C Q C NG C + C CP F G CEK L +F G +SY+EL
Sbjct: 2101 SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNG-NSYLELP 2159
Query: 1173 SAKV------RPQANISLQVATDKDNGILLYKGDNDP----LALELYQGHVRLVYDSLSS 1222
K I L + T+ NG +LY N+ L L L +G + Y +S
Sbjct: 2160 FLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNS 2219
Query: 1223 PPT-TVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQK----QPAV------ 1271
TV + ++N F + T+ G+P + ++ +P V
Sbjct: 2220 QNILTVSANYSINTNAFTPI-------TIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTE 2272
Query: 1272 ------GINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQS 1325
++LG IP + + + G P+ GF GCI ++++NN ++F +
Sbjct: 2273 ISHASQAYFESMFLGHIPANVQIHK-KAG---PVYGFRGCILDLQVNN--KEFFIIDEAR 2326
Query: 1326 LGVSPGCKSCTV--CKHGLCRS-----VEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH 1378
G ++C V C H LCR+ + +++ CEC ++G LC + C + C
Sbjct: 2327 HG--KNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS---CENNPCG 2381
Query: 1379 HG-KCV-ATGTSYMCKCAEGYGGDLC 1402
+G CV +GT +C C G G LC
Sbjct: 2382 NGATCVPKSGTDIVCLCPYGRSGPLC 2407
Score = 64.7 bits (156), Expect = 7e-10
Identities = 43/145 (29%), Positives = 62/145 (42%), Gaps = 15/145 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH------GKCV-A 1384
C S G C+ C C G+TG C++ D C + G CV
Sbjct: 1083 CTSIPCMNEGFCQK-SAHGFTCICPRGYTGAYCEKSI-DNCAEPELNSVICLNGGICVDG 1140
Query: 1385 TGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHC 1443
G ++ C+C G+ G C+ + N CS+ C HG D Y C CQPG+SG HC
Sbjct: 1141 PGHTFDCRCLPGFSGQFCEI---NINECSSSPCLHG-ADCEDHINGYVCKCQPGWSGHHC 1196
Query: 1444 QQENPCL-GQVVREVIRRQKGYASC 1467
+ E C+ V E+ + ++C
Sbjct: 1197 ENELECIPNSCVHELCMENEPGSTC 1221
Score = 62.4 bits (150), Expect = 3e-09
Identities = 53/193 (27%), Positives = 69/193 (35%), Gaps = 43/193 (22%)
Query: 1301 GFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWT 1360
GF G + E+ IN C S +G C + + C C P +
Sbjct: 919 GFSGSLCEIEINE------------------CSSEPCKNNGTCVDLT-NRFFCNCEPEYH 959
Query: 1361 GPLCDQEAR----DPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFK 1416
GP C+ + PCL CV Y C CA GY G C+ D C +
Sbjct: 960 GPFCELDVNKCKISPCLDEE----NCVYRTDGYNCLCAPGYTGINCEINLDE---CLSEP 1012
Query: 1417 CHHGQCHISDQGEPYCLCQPGFSGEHCQQ------ENPCLGQVVREVIRRQKGYASC--- 1467
C H I C C+ GF G HC+ NPCL E+I SC
Sbjct: 1013 CLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYP--CSCDAD 1070
Query: 1468 --ATASKVPIMEC 1478
+T K+ I +C
Sbjct: 1071 GTSTQCKIKINDC 1083
Score = 62.0 bits (149), Expect = 4e-09
Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 6/176 (3%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C+S G C Y CP ++ ++ PCQ+G C +
Sbjct: 298 CVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI---KISND 353
Query: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
C C F C+ CE NNATC +Y C C +T + C++ IDHC
Sbjct: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
Query: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
C +E C + F C+PG + C + + H +H C T +G
Sbjct: 414 LLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIH--QHLCYCGVTFHG 467
Score = 60.1 bits (144), Expect = 2e-08
Identities = 33/95 (34%), Positives = 51/95 (53%), Gaps = 8/95 (8%)
Query: 950 KDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNA 1009
++C VP C + C++ GTC +SD+ + C CP + G+ C+ CE+N C N A
Sbjct: 2332 ENCHVP--WCAHHLCRNNGTC-ISDN--ENLFCECPRLYSGKLCQFA--SCENNPCGNGA 2384
Query: 1010 TCVDGIN-NYVCICPPNYTGELCDEVIDHCVPELN 1043
TCV + VC+CP +G LC + I+ P +
Sbjct: 2385 TCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFS 2419
Score = 59.3 bits (142), Expect = 3e-08
Identities = 34/110 (30%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTS 1388
P S G+C + C C PG++G C+ + C C HG C
Sbjct: 1124 PELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININE-CSSSPCLHGADCEDHING 1182
Query: 1389 YMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGF 1438
Y+CKC G+ G C+N+ + C C H C ++ G CLC PGF
Sbjct: 1183 YVCKCQPGWSGHHCENELE----CIPNSCVHELCMENEPGST-CLCTPGF 1227
Score = 57.4 bits (137), Expect = 1e-07
Identities = 30/103 (29%), Positives = 47/103 (45%), Gaps = 6/103 (5%)
Query: 1349 DSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKND 1407
D C C PG+ G C+Q+ D C+ + C H+ C SY C C + G+ C+ +
Sbjct: 715 DGFSCLCNPGYVGIRCEQDI-DDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQE-- 771
Query: 1408 SANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
+N C C + C C G++G++C +E N C
Sbjct: 772 -SNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINEC 813
Score = 57.0 bits (136), Expect = 1e-07
Identities = 33/88 (37%), Positives = 44/88 (50%), Gaps = 11/88 (12%)
Query: 914 VAKCNA--CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC-----IQNPCQH 966
V +C+A C C N GTC + +Y C C +KG CT ++TC + C
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSR 2664
Query: 967 GGTCHLSDSHKDGFSCSCPLGFEGQRCE 994
G TC +S H G++C CPLG G CE
Sbjct: 2665 GATC-ISLPH--GYTCFCPLGTTGIYCE 2689
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/74 (41%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
C C+NNGTC D L+ C CP Y GK C +C NPC +G TC + S D
Sbjct: 2339 CAHHLCRNNGTCISDNENLF-CECPRLYSGKLC--QFASCENNPCGNGATC-VPKSGTD- 2393
Query: 980 FSCSCPLGFEGQRC 993
C CP G G C
Sbjct: 2394 IVCLCPYGRSGPLC 2407
Score = 55.1 bits (131), Expect = 5e-07
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 5/109 (4%)
Query: 1337 VCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHGKCVATGTSYMCKCAE 1395
VC HG C ++ +S +CEC ++GP C+ A+ PC+ G C + ++Y +C +
Sbjct: 264 VCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTYECPK 322
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
G N + S C +G I + C+C P F+ C+
Sbjct: 323 GSSS---QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
Score = 55.1 bits (131), Expect = 5e-07
Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 5/84 (5%)
Query: 992 RCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPE---LNLCQHE 1048
+C +P C C N TC++ + C C + G C E + C PE + C
Sbjct: 2608 QCHASP--CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665
Query: 1049 AKCIPLDKGFSCECVPGYSGKLCE 1072
A CI L G++C C G +G CE
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 55.1 bits (131), Expect = 5e-07
Identities = 54/197 (27%), Positives = 91/197 (46%), Gaps = 32/197 (16%)
Query: 1072 ETDNDDCVAHKCRHGAQCVDTING--YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQ 1129
+ D C + CR+G +C T+NG ++C C ++G C Q+ C C
Sbjct: 2873 DCDGTACGYNTCRNGGEC--TVNGTTFSCRCLPDWAGNTCN--------QSVSCLNNLCL 2922
Query: 1130 NGAQCIVVQQ-EPTCRCPPGFAGPRCE---KLITVNFVGKDSYVELASAKVRPQ----AN 1181
+ + CI Q +C C G+ G CE T F+G +SY++ R +
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMG-NSYIKYIDPNYRMRNLQFTT 2981
Query: 1182 ISLQVATDKDNGILLYKG-----DNDPLALELYQGHVRLVY---DSLSSPPTTVYSVETV 1233
ISL +T K G++++ G +ND LA+ L+ +++ + +S P + Y+ T
Sbjct: 2982 ISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMS--YNNGTF 3039
Query: 1234 NDGQFHSVELVTLNQTL 1250
++H V +V NQTL
Sbjct: 3040 CCNKWHHV-VVIQNQTL 3055
Score = 53.1 bits (126), Expect = 2e-06
Identities = 31/118 (26%), Positives = 48/118 (40%), Gaps = 9/118 (7%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEAR----DPCL-GHRCHHGKCVATG 1386
CK + C + K S CEC GWTG C +E DPC+ G CH
Sbjct: 775 CKMNPCKNNSTCTDLYK-SYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPG-- 831
Query: 1387 TSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
++C C Y G C + + + ++ C +C+C+ F G++C+
Sbjct: 832 -QFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCE 888
Score = 53.1 bits (126), Expect = 2e-06
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 6/75 (8%)
Query: 1000 CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGF- 1058
C N C N C + C C P++ G C++ + C+ NLC H++ CIP D+ F
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLN--NLCLHQSLCIP-DQSFS 2934
Query: 1059 -SCECVPGYSGKLCE 1072
SC C G+ G+ CE
Sbjct: 2935 YSCLCTLGWVGRYCE 2949
Score = 50.8 bits (120), Expect = 1e-05
Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 48/268 (17%)
Query: 1166 DSYVELASAKVRPQANISLQVATDKDNGILLY-KGDN---DPLALELYQGHVRLVYDSLS 1221
DSY+E + + PQ NISL+ T G+LLY K D+ D ++L+ + L Y
Sbjct: 1891 DSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYC 1950
Query: 1222 SPPTTVYSVET---VNDGQFHSV-----------ELVTLN------QTLNLVVDKGTPKS 1261
S+ T V++GQ +++ EL L +++N V+ K PKS
Sbjct: 1951 PGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKS 2010
Query: 1262 LGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKAL 1321
+++GG P G + P+ F GCI + INN +
Sbjct: 2011 -------------GSVFIGGFPDLHGKIQM----PVPVKNFTGCIEVIEINNWRSFIPSK 2053
Query: 1322 PPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK 1381
++ ++ C+S V+ V WT A C CH+G
Sbjct: 2054 AVKNYHIN-NCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGG 2112
Query: 1382 C-----VATG-TSYMCKCAEGYGGDLCD 1403
+++G S+ C C + G C+
Sbjct: 2113 TCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 50.1 bits (118), Expect = 2e-05
Identities = 28/73 (38%), Positives = 34/73 (46%), Gaps = 5/73 (6%)
Query: 1000 CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLD-KGF 1058
C + C NN TC+ N C CP Y+G+LC C E N C + A C+P
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASC--ENNPCGNGATCVPKSGTDI 2394
Query: 1059 SCECVPGYSGKLC 1071
C C G SG LC
Sbjct: 2395 VCLCPYGRSGPLC 2407
Score = 48.5 bits (114), Expect = 5e-05
Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 20/154 (12%)
Query: 1340 HGLCRSVE-KDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTS-----YMCK 1392
HG C S + C C+P ++G C + D C C ++G C+ + Y C
Sbjct: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQE--LDACSFKPCKNNGSCINKRENWDEQAYECV 243
Query: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLG 1451
C + G C ++ C C HG C C C FSG C+ PC+
Sbjct: 244 CHPPFTGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV- 299
Query: 1452 QVVREVIRRQKGYASCATASKVPIMECRGGCGPQ 1485
++ ++G C +S EC G Q
Sbjct: 300 ----SLLFWKRGI--CPNSSSAYTYECPKGSSSQ 327
Score = 48.5 bits (114), Expect = 5e-05
Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 8/82 (9%)
Query: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCED-----NDCENNATCVD 1013
C C +GGTC S + C+C G++G C C+ + C ATC+
Sbjct: 2614 CSLMKCGNGGTCIESGT---SVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670
Query: 1014 GINNYVCICPPNYTGELCDEVI 1035
+ Y C CP TG C++ +
Sbjct: 2671 LPHGYTCFCPLGTTGIYCEQAL 2692
Score = 48.5 bits (114), Expect = 5e-05
Identities = 32/108 (29%), Positives = 46/108 (42%), Gaps = 13/108 (12%)
Query: 919 ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKD 978
AC + C+N G CT + + C C + G C ++ C+ N C H C S
Sbjct: 2878 ACGYNTCRNGGECTVNGTT-FSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFS- 2934
Query: 979 GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNY 1026
+SC C LG+ G+ CE N + G N+Y+ PNY
Sbjct: 2935 -YSCLCTLGWVGRYCE--------NKTSFSTAKFMG-NSYIKYIDPNY 2972
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/129 (30%), Positives = 52/129 (40%), Gaps = 20/129 (15%)
Query: 1332 CKSCTVCKHGLCR-SVEKDSVVCECRPGWTGPLCDQE------ARDPCLGHRCHHGKCVA 1384
C S GLC S VC C P +TG C Q +PC ++ C+A
Sbjct: 813 CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCR----NNSTCLA 868
Query: 1385 -TGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCH-HGQCHISDQGEPY-CLCQPGFSGE 1441
+ C C E + G C+ C C +G C D + C+C+PGFSG
Sbjct: 869 LVDANQHCICREEFEGKNCEI---DVKDCLFLSCQDYGDCE--DMVNNFRCICRPGFSGS 923
Query: 1442 HCQQE-NPC 1449
C+ E N C
Sbjct: 924 LCEIEINEC 932
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/109 (26%), Positives = 45/109 (41%), Gaps = 6/109 (5%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH--HGKCVATGTSYMCKCAE 1395
C+H E + C C + G LC D CLG+ HG C+A + C +
Sbjct: 575 CQHEAVCKDEINRPRCSCSLSYIGRLCVVNV-DYCLGNHSISVHGLCLALSHNCNCSGLQ 633
Query: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
Y ++C+ + C + C +G +G + C PGF G C+
Sbjct: 634 RYERNICEIDTED---CKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCE 679
Score = 40.0 bits (92), Expect = 0.017
Identities = 30/128 (23%), Positives = 49/128 (38%), Gaps = 24/128 (18%)
Query: 1336 TVCKHGLCRSVEKDSVVCECR--PGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC-K 1392
++ HGLC ++ + C C + +C+ + D C C +G Y K
Sbjct: 613 SISVHGLCLALSHN---CNCSGLQRYERNICEIDTED-CKSASCKNGTTSTHLRGYFFRK 668
Query: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCL--------------CQPGF 1438
C G+ G C+ D C++ C +G I G +C C PG+
Sbjct: 669 CVPGFKGTQCEIDIDE---CASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGY 725
Query: 1439 SGEHCQQE 1446
G C+Q+
Sbjct: 726 VGIRCEQD 733
Score = 40.0 bits (92), Expect = 0.017
Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 957 NTCIQNPCQHGGTCH--LSDSHKDGFSCSCPLGFEGQRCE 994
+ C Q+ C +GGTCH S F C CPL F G+ CE
Sbjct: 2101 SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 35.8 bits (81), Expect = 0.32
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 5/52 (9%)
Query: 997 PDDCEDNDCENNATC-----VDGINNYVCICPPNYTGELCDEVIDHCVPELN 1043
P C+ + C N TC GI ++ C CP ++TG C++ P N
Sbjct: 2100 PSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFN 2151
Score = 35.0 bits (79), Expect = 0.55
Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 1413 SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQENPC 1449
S F HG+C + Y C CQP FSG++CQ+ + C
Sbjct: 180 SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
Score = 34.7 bits (78), Expect = 0.72
Identities = 15/39 (38%), Positives = 18/39 (46%)
Query: 919 ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPIN 957
+C ++PC N TC C CPY G CT IN
Sbjct: 2374 SCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN 2412
Score = 31.6 bits (70), Expect = 6.1
Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 11/118 (9%)
Query: 1334 SCTVCKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMC 1391
S C++G C + D V+C C P +T LC + + C ++ C Y C
Sbjct: 337 SLVPCQNGTDCIKISND-VMCICSPIFTDLLC-KSIQTSCESFPLRNNATCKKCEKDYPC 394
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPC 1449
C G+ C+ D S C + + + G +C PG + +NPC
Sbjct: 395 SCISGFTEKNCEKAIDHCKLLS-INCLNEEWCFNIIGRFKYVCIPGCT------KNPC 445
Score = 31.2 bits (69), Expect = 8.0
Identities = 13/37 (35%), Positives = 17/37 (45%)
Query: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
A+ CS KC +G I YC C G+ G C +
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTE 2647
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 171 bits (434), Expect = 4e-42
Identities = 96/275 (34%), Positives = 122/275 (44%), Gaps = 45/275 (16%)
Query: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
N C S PC+N GTCT + +RC CP + G C + C CQHGG C + +
Sbjct: 313 NECASQPCQNGGTCTHG-INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSA 371
Query: 978 DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH 1037
C C G+ G CE++ DDC + C N +CVD + NY C+C + G C E DH
Sbjct: 372 ---VCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRC-ETGDH 427
Query: 1038 CVPELNL---CQHEAKCIPLDKGFSCECVPGYSGKLC-ETDNDDCVAHKCRHGAQCVDTI 1093
VP+ L C + C+ D+G+ CEC G+ G C E DDC +CR+G +C+
Sbjct: 428 PVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDC---ECRNGGRCLGA- 483
Query: 1094 NGYTCTCPQGFSGPFCEHP----PPMVLLQT----------------------------S 1121
N C CP GF G CE P + Q S
Sbjct: 484 NTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPS 543
Query: 1122 PCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
PCD C NG C TC CP GF G CEK
Sbjct: 544 PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEK 578
Score = 171 bits (433), Expect = 5e-42
Identities = 88/251 (35%), Positives = 121/251 (48%), Gaps = 25/251 (9%)
Query: 918 NACLS-SPCKNNGTCTQDPVE---LYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
+ CL+ PC N G C D V Y C+C + G+ C + +N C PCQ+GGTC
Sbjct: 270 SVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTC--- 326
Query: 974 DSHK-DGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD 1032
+H + F C CP GF G CE C+ +C++ C + VC+C YTG C+
Sbjct: 327 -THGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACE 385
Query: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN----DDCVAHKCRHGAQ 1088
+D C P+ C + C+ L ++C C + G CET + D C++ C +G
Sbjct: 386 MDVDDCSPDP--CLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGT 443
Query: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148
CVD GY C CP+GF G C P D EC+NG +C+ C+CP G
Sbjct: 444 CVDADQGYVCECPEGFMGLDCRERVP---------DDCECRNGGRCLGA-NTTLCQCPLG 493
Query: 1149 FAGPRCEKLIT 1159
F G CE IT
Sbjct: 494 FFGLLCEFEIT 504
Score = 164 bits (414), Expect = 8e-40
Identities = 92/299 (30%), Positives = 123/299 (41%), Gaps = 70/299 (23%)
Query: 915 AKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTV-PINTCIQNPCQHGGTCHLS 973
A+ + C S PC+N GTC + E Y C+CPY + G+ C + ++C PC +GGTC
Sbjct: 579 ARPHLCSSGPCRNGGTCKEAGGE-YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCF-- 635
Query: 974 DSHKDG-FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD 1032
H G + C CP GF G+ CEI P C + C N TC D ++ C C Y G C
Sbjct: 636 --HYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 693
Query: 1033 EVIDHCVPE---------------------------------LNLCQ------HEAKCIP 1053
+D PE + +CQ +C+
Sbjct: 694 AEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLE 753
Query: 1054 LDK-----------------GFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
+D+ G+ C C GY G CE + D+C AH CR+G C + Y
Sbjct: 754 IDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAY 813
Query: 1097 TCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
C CP GF G CE + CD CQ+G +C C CP F G CE
Sbjct: 814 VCRCPAGFVGVHCE-------TEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCE 865
Score = 151 bits (382), Expect = 4e-36
Identities = 74/213 (34%), Positives = 101/213 (47%), Gaps = 15/213 (7%)
Query: 952 CTVPINTCIQ-NPCQHGGTCHLSD--SHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENN 1008
C + C+ PC +GG C + D + ++CSC GF G+RC ++ ++C C+N
Sbjct: 265 CGHTTSVCLALRPCLNGGKC-IDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNG 323
Query: 1009 ATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSG 1068
TC GIN++ C CP + G C+ C + CQH +C + C C GY+G
Sbjct: 324 GTCTHGINSFRCQCPAGFGGPTCETAQSPC--DTKECQHGGQCQVENGSAVCVCQAGYTG 381
Query: 1069 KLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE---HPPPMVLLQTSPCDQ 1125
CE D DDC C +G CVD + YTC C + F G CE HP P C
Sbjct: 382 AACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVP------DACLS 435
Query: 1126 YECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
C NG C+ Q C CP GF G C + +
Sbjct: 436 APCHNGGTCVDADQGYVCECPEGFMGLDCRERV 468
Score = 140 bits (354), Expect = 7e-33
Identities = 90/279 (32%), Positives = 115/279 (41%), Gaps = 57/279 (20%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTV---PI-NTCIQNPCQHGGTCHLSDS 975
C PC N G+C D V Y C C +KG C P+ + C+ PC +GGTC +D
Sbjct: 391 CSPDPCLNGGSCV-DLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQ 449
Query: 976 HKDGFSCSCPLGFEGQRC-EINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC--- 1031
G+ C CP GF G C E PDDCE C N C+ G N +C CP + G LC
Sbjct: 450 ---GYVCECPEGFMGLDCRERVPDDCE---CRNGGRCL-GANTTLCQCPLGFFGLLCEFE 502
Query: 1032 -------------------------------DEVIDHCVP---ELNLCQHEAKCIPLDKG 1057
D H +P + + C + C D
Sbjct: 503 ITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDS 562
Query: 1058 FSCECVPGYSGKLCETDNDD-CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMV 1116
++CEC G+ GK CE C + CR+G C + Y C+CP F+G CE P
Sbjct: 563 YTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKP-- 620
Query: 1117 LLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
C C NG C + C CPPGF+G CE
Sbjct: 621 ----DSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCE 655
Score = 135 bits (339), Expect = 4e-31
Identities = 78/301 (25%), Positives = 114/301 (37%), Gaps = 71/301 (23%)
Query: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
+ K ++C S PC N GTC + Y+C CP + G+ C + + C ++PC +GGTC
Sbjct: 617 IGKPDSCASGPCHNGGTCFHY-IGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDR 675
Query: 974 DSHKDGFSCSCP------------------------LGFEGQR----------------- 992
D+ F C C L F G R
Sbjct: 676 DTD---FFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSA 732
Query: 993 ------CE-----------INPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVI 1035
C+ + D+C C + +C D + Y+C+C Y G C+
Sbjct: 733 PSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELER 792
Query: 1036 DHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
D C + C++ C L + C C G+ G CET+ D C + C+HG +C
Sbjct: 793 DEC--RAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGA 850
Query: 1096 YTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
Y C CP+ F G CE + PC C C+ +C C G+ G C
Sbjct: 851 YLCVCPESFFGYHCE-------TVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCA 903
Query: 1156 K 1156
K
Sbjct: 904 K 904
Score = 115 bits (289), Expect = 2e-25
Identities = 69/258 (26%), Positives = 97/258 (37%), Gaps = 66/258 (25%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGK------DCTVP------------------ 955
C SPC N GTC + + C C Y G+ DC P
Sbjct: 661 CFRSPCVNGGTCEDRDTDFF-CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAV 719
Query: 956 ----------------------------------INTCIQNPCQHGGTCHLSDSHKDGFS 981
I+ C PC HGG+C G+
Sbjct: 720 ALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQ---DRVAGYL 776
Query: 982 CSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPE 1041
C C G+EG CE+ D+C + C N +C + YVC CP + G C+ +D C +
Sbjct: 777 CLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDAC--D 834
Query: 1042 LNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCP 1101
+ CQH +C + C C + G CET +D C + C C+ + ++CTC
Sbjct: 835 SSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCK 894
Query: 1102 QGFSGPFC--EHPPPMVL 1117
G++G C E PP L
Sbjct: 895 VGYTGEDCAKELFPPTAL 912
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/146 (32%), Positives = 69/146 (47%), Gaps = 18/146 (12%)
Query: 1315 LQDFKALPPQSLGVSPGCKSCTV------CKHGLCRSVEKDSVVCECRPGWTGPLCDQE- 1367
+ F+ P G P C++ C+HG VE S VC C+ G+TG C+ +
Sbjct: 330 INSFRCQCPAGFG-GPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDV 388
Query: 1368 ---ARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSA-NACSAFKCHH-GQC 1422
+ DPCL + G CV +Y C CAE + G C+ + +AC + CH+ G C
Sbjct: 389 DDCSPDPCL----NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444
Query: 1423 HISDQGEPYCLCQPGFSGEHCQQENP 1448
+DQG C C GF G C++ P
Sbjct: 445 VDADQGY-VCECPEGFMGLDCRERVP 469
Score = 71.2 bits (173), Expect = 7e-12
Identities = 44/130 (33%), Positives = 60/130 (46%), Gaps = 8/130 (6%)
Query: 1322 PPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG- 1380
PPQ L + C+S C HG +C C G+ G C+ E RD C H C +G
Sbjct: 748 PPQCLEIDE-CRS-QPCLHGGSCQDRVAGYLCLCSTGYEGAHCELE-RDECRAHPCRNGG 804
Query: 1381 KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG 1440
C +Y+C+C G+ G C+ + D AC + C HG S G C+C F G
Sbjct: 805 SCRNLPGAYVCRCPAGFVGVHCETEVD---ACDSSPCQHGGRCESGGGAYLCVCPESFFG 861
Query: 1441 EHCQQ-ENPC 1449
HC+ +PC
Sbjct: 862 YHCETVSDPC 871
Score = 67.8 bits (164), Expect = 8e-11
Identities = 43/145 (29%), Positives = 64/145 (44%), Gaps = 20/145 (13%)
Query: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGYGGDLCDNKNDS 1408
S C C G+TG C + + C C + G C S+ C+C G+GG C+ +
Sbjct: 294 SYTCSCLSGFTGRRCHLDVNE-CASQPCQNGGTCTHGINSFRCQCPAGFGGPTCET---A 349
Query: 1409 ANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGEHCQQE------NPCL--GQVVREVIR 1459
+ C +C H GQC + + G C+CQ G++G C+ + +PCL G V V
Sbjct: 350 QSPCDTKECQHGGQCQV-ENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLV-- 406
Query: 1460 RQKGYASCATASKVPIMECRGGCGP 1484
G +C A + C G P
Sbjct: 407 ---GNYTCLCAEPFKGLRCETGDHP 428
Score = 66.6 bits (161), Expect = 2e-10
Identities = 39/115 (33%), Positives = 52/115 (45%), Gaps = 6/115 (5%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEG 1396
C +G DS CEC G+ G C++ C C +G C G Y C C
Sbjct: 550 CFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYR 609
Query: 1397 YGGDLCD-NKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPC 1449
+ G C+ K DS C++ CH+G G+ C C PGFSG HC+ +PC
Sbjct: 610 FTGRHCEIGKPDS---CASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPC 661
Score = 64.7 bits (156), Expect = 7e-10
Identities = 38/117 (32%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 1329 SPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGT 1387
S C++ C HG+ +S C+C G+ GP C + A+ PC C H G+C
Sbjct: 317 SQPCQNGGTCTHGI------NSFRCQCPAGFGGPTC-ETAQSPCDTKECQHGGQCQVENG 369
Query: 1388 SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
S +C C GY G C+ D CS C +G + G CLC F G C+
Sbjct: 370 SAVCVCQAGYTGAACEMDVDD---CSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 423
Score = 64.7 bits (156), Expect = 7e-10
Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 8/117 (6%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
C++ G CR++ + VC C G+ G C+ E D C C HG +C + G +Y+
Sbjct: 795 CRAHPCRNGGSCRNLP-GAYVCRCPAGFVGVHCETEV-DACDSSPCQHGGRCESGGGAYL 852
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCH-HGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
C C E + G C+ +D C + C G C ++ G C C+ G++GE C +E
Sbjct: 853 CVCPESFFGYHCETVSDP---CFSSPCGGRGYC-LASNGSHSCTCKVGYTGEDCAKE 905
Score = 59.3 bits (142), Expect = 3e-08
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 907 GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQH 966
G V ++ + +AC SSPC++ G C + Y C CP S+ G C + C +PC
Sbjct: 820 GFVGVHCETEVDACDSSPCQHGGRC-ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGG 878
Query: 967 GGTCHLSDSHKDGFSCSCPLGFEGQRC 993
G C S+ SC+C +G+ G+ C
Sbjct: 879 RGYCLASNG---SHSCTCKVGYTGEDC 902
Score = 52.8 bits (125), Expect = 3e-06
Identities = 33/119 (27%), Positives = 46/119 (38%), Gaps = 9/119 (7%)
Query: 1337 VCKHGLCRS-----VEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
+C G CR+ C C +TG C+ D C CH+G C Y
Sbjct: 583 LCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYK 642
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPC 1449
C C G+ G C+ + + C C +G + +C CQ G+ G CQ E C
Sbjct: 643 CDCPPGFSGRHCEI---APSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDC 698
Score = 50.1 bits (118), Expect = 2e-05
Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 9/116 (7%)
Query: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARD-PC-LGHRCHHGK-CVATGTSYMCKCA 1394
C++G R + ++ +C+C G+ G LC+ E PC + +C G C+ G SY+C C
Sbjct: 474 CRNG-GRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCH 532
Query: 1395 EGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCL 1450
+ + + C + C +G + C C GF G+HC++ P L
Sbjct: 533 TDHNAS-----HSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHL 583
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/123 (26%), Positives = 51/123 (41%), Gaps = 7/123 (5%)
Query: 1328 VSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATG 1386
V C S G C ++ VCEC G+ G C + D C C + G+C+
Sbjct: 429 VPDACLSAPCHNGGTCVDADQ-GYVCECPEGFMGLDCRERVPDDC---ECRNGGRCLGAN 484
Query: 1387 TSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE 1446
T+ +C+C G+ G LC+ + + +C G + G C+C + H
Sbjct: 485 TT-LCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASH-SLP 542
Query: 1447 NPC 1449
+PC
Sbjct: 543 SPC 545
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/42 (52%), Positives = 27/42 (64%), Gaps = 4/42 (9%)
Query: 954 VPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEI 995
VP N C +NPCQ+GGTC D SC C GF+G+RCE+
Sbjct: 1307 VPGN-CSENPCQNGGTC---VPGADAHSCDCGPGFKGRRCEL 1344
Score = 45.4 bits (106), Expect = 4e-04
Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 9/90 (10%)
Query: 997 PDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQH---EAKCIP 1053
P +C +N C+N TCV G + + C C P + G C+ C+ C E K P
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA---CIKVSRPCTRLFSETKAFP 1364
Query: 1054 LDKGFSCECVPGYSGKLCETDNDDCVAHKC 1083
+ +G C V ++ D C C
Sbjct: 1365 VWEGGVCHHV---YKRVYRVHQDICFKESC 1391
Score = 40.0 bits (92), Expect = 0.017
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCE 1155
C + CQNG C+ +C C PGF G RCE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 36.6 bits (83), Expect = 0.19
Identities = 28/97 (28%), Positives = 37/97 (38%), Gaps = 25/97 (25%)
Query: 889 PMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYK 948
P L L P H + G V N C +PC+N GTC + + C C +K
Sbjct: 1287 PKRVSLALQLPEHGSKDIGNVPGN-------CSENPCQNGGTCVPG-ADAHSCDCGPGFK 1338
Query: 949 GKDCTVPINTCIQ--NPCQ------------HGGTCH 971
G+ C + CI+ PC GG CH
Sbjct: 1339 GRRCEL---ACIKVSRPCTRLFSETKAFPVWEGGVCH 1372
Score = 34.3 bits (77), Expect = 0.95
Identities = 12/34 (35%), Positives = 19/34 (55%)
Query: 1077 DCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
+C + C++G CV + ++C C GF G CE
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 164 bits (415), Expect = 6e-40
Identities = 129/435 (29%), Positives = 195/435 (44%), Gaps = 42/435 (9%)
Query: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339
CP C C V C + L +P ++P I + S + AF L ++
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
Query: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399
Q+ PDAF GL L L + G+ ++ +F L SL L LN N + L F
Sbjct: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 400 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET 459
Q L L L L N+LQ + + LF PL ++TL+LAQN L P E
Sbjct: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN-------------LLAQLPEEL 188
Query: 460 SGARCS-SPRRLANKRISQIKSKKFRCSGS-------EDYRSRFSSECFMDLVCPEKCRC 511
S +L+N +S + F GS + S + F L C E+
Sbjct: 189 FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWL 248
Query: 512 EGTIVDCSNQKLVRIPSHLPEYV-------TDLRLNDNEVSVLEATGIFKKLPNLRKINL 564
+ + +HLP + T L L N + VL A G+F P L ++L
Sbjct: 249 QRNAI-----------THLPLSIFASLGNLTFLSLQWNMLRVLPA-GLFAHTPCLVGLSL 296
Query: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624
++N+++ V EG F ++++ LML+ N + + +FR L L L L SN + +
Sbjct: 297 THNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
Query: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK--RR 682
F LS + LLSL N++TT+ G F T +L + L NP+ C+CHLA+L WL++ R
Sbjct: 357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDR 416
Query: 683 IVSGNPRCQKPFFLK 697
+++ C P +LK
Sbjct: 417 LLNIQTYCAGPAYLK 431
Score = 145 bits (365), Expect = 4e-34
Identities = 113/469 (24%), Positives = 197/469 (42%), Gaps = 32/469 (6%)
Query: 25 VLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGL 84
+L PA CP C C V C L VP IP + + + T + F
Sbjct: 13 LLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSN 72
Query: 85 KNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQ 144
NL + + Q+ AF L +LE L + + L +F + L +L L+ N
Sbjct: 73 PNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
Query: 145 IQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHM 204
++ +P F+ + +++L L N + + F+ L L+ L L N ++++ F+ +
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 205 PKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCP 264
++TL+L +N ++ + F ++ ++
Sbjct: 193 TSLQTLKLSNN--------------------------ALSGLPQGVFGKLGSLQELFLDS 226
Query: 265 APHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPA 324
SE P + + C N + + NL + L+ N ++ +PA
Sbjct: 227 NNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL----TFLSLQWNMLRVLPA 282
Query: 325 GAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLL 384
G F L + ++ NQ+ +A F L +L SL+L N IT + G+F L L L
Sbjct: 283 GLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKL 342
Query: 385 LLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCH 444
L +N + L FQ+L L LLSL N+L T+ +G+F ++ L L NP+ CDCH
Sbjct: 343 YLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCH 402
Query: 445 LKWLADYLQD--NPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDY 491
L +L ++LQ + + C+ P L + + + K+ C + D+
Sbjct: 403 LAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCPVTRDH 451
Score = 124 bits (312), Expect = 5e-28
Identities = 108/402 (26%), Positives = 180/402 (44%), Gaps = 45/402 (11%)
Query: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564
CP C C V CS+++L +P +P Y ++ + + LE T F PNL K+
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE-TRAFGSNPNLTKVVF 80
Query: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624
N ++ + R AF G +++L +TG+ + +F L+ L L L N++ +
Sbjct: 81 LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN-----PFNCNCHLAWLGKWLR 679
F L+++ L L N++ + F L L T+NL N P L L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKL 200
Query: 680 KRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCS 739
+SG P+ F K +Q++ + D N S +L P+ Q C+E +
Sbjct: 201 SNNALSGLPQ---GVFGKLGSLQELFL-----DSNNIS--ELPPQVFSQLFCLERLWLQR 250
Query: 740 NKGLRALPRGMPK---DVTELYLEGNHLTAVPRELSALRH-LTLIDLSNNSISMLTNYTF 795
N + LP + ++T L L+ N L +P L A L + L++N + + TF
Sbjct: 251 N-AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTF 309
Query: 796 SNMSHLSTLILSYNRLRCIPVHAFNGLRSL------------------------RVLTLH 831
+++S+L +L+LSYN + +P F L L +L+L
Sbjct: 310 AHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369
Query: 832 GNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873
N ++++PEG F+ +L +LAL NP CDC L +L W++
Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQ 411
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 157 bits (397), Expect = 7e-38
Identities = 85/262 (32%), Positives = 117/262 (44%), Gaps = 42/262 (16%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT--------------------- 958
C + +G C Q P E C C + G CTVP++T
Sbjct: 220 CRAGCSPEHGFCEQ-PGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
Query: 959 --CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
C NPC +GG+C S++ + F C+CP GF G RCE++ C D C N CV G +
Sbjct: 276 GPCDGNPCANGGSC--SETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD 332
Query: 1017 N---YVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCET 1073
Y+C CPP + G C++ +D C L C++ C+ L C C G++G CE
Sbjct: 333 PDSAYICHCPPGFQGSNCEKRVDRC--SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEH 390
Query: 1074 DNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQ 1133
D DDC C +G CV+ + C+C GF G C + PC C +G +
Sbjct: 391 DLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE-------RADPCAARPCAHGGR 443
Query: 1134 CIVVQQEPTCRCPPGFAGPRCE 1155
C C C PG+ G RCE
Sbjct: 444 CYAHFSGLVCACAPGYMGARCE 465
Score = 139 bits (349), Expect = 3e-32
Identities = 74/246 (30%), Positives = 100/246 (40%), Gaps = 20/246 (8%)
Query: 877 KEPGIARC----SSPEPMADRLLLTTPTHRFQC---KGPVDIN---IVAKCNACLSSPCK 926
++PG RC + P L T P C +GP +V C +PC
Sbjct: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
Query: 927 NNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPL 986
N G+C++ P + C CP + G C V TC PC +GG C + C CP
Sbjct: 285 NGGSCSETP-RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Query: 987 GFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQ 1046
GF+G CE D C C N C+D + C C + G C+ +D C C
Sbjct: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
Query: 1047 HEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSG 1106
+ C+ C C G+ G+ C D C A C HG +C +G C C G+ G
Sbjct: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
Query: 1107 PFCEHP 1112
CE P
Sbjct: 462 ARCEFP 467
Score = 71.6 bits (174), Expect = 5e-12
Identities = 39/106 (36%), Positives = 56/106 (52%), Gaps = 8/106 (7%)
Query: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGG 1399
GLC + ++ C CR G+ GP C+ + D C G C + G CV G ++ C CA G+GG
Sbjct: 366 GLCLDLGH-ALRCRCRAGFAGPRCEHDL-DDCAGRACANGGTCVEGGGAHRCSCALGFGG 423
Query: 1400 DLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
C + A+ C+A C H G+C+ G C C PG+ G C+
Sbjct: 424 RDC---RERADPCAARPCAHGGRCYAHFSG-LVCACAPGYMGARCE 465
Score = 67.8 bits (164), Expect = 8e-11
Identities = 46/173 (26%), Positives = 63/173 (36%), Gaps = 43/173 (24%)
Query: 1021 ICPPNYTGELCDEVIDHCVPELNLCQH----EAKCIPLDKGF-----SCECVPGYSGKLC 1071
+C P C + C P + C+ A C P + GF C C+ G++G LC
Sbjct: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSP-EHGFCEQPGECRCLEGWTGPLC 248
Query: 1072 ETDNDD-----------------------CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1108
C + C +G C +T + CTCP+GF G
Sbjct: 249 TVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLR 308
Query: 1109 CEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT---CRCPPGFAGPRCEKLI 1158
CE + C C NG C+ + C CPPGF G CEK +
Sbjct: 309 CE-------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Score = 61.6 bits (148), Expect = 6e-09
Identities = 57/221 (25%), Positives = 81/221 (36%), Gaps = 50/221 (22%)
Query: 1332 CKSCTVCK------HGLCRSVEKDSVVCECRPGWTGPLCDQEAR---------------- 1369
C++ VC+ HG C + C C GWTGPLC
Sbjct: 214 CEAPLVCRAGCSPEHGFCEQPGE----CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG 269
Query: 1370 ------DPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQC 1422
PC G+ C + G C T S+ C C G+ G C+ S C+ C +G
Sbjct: 270 CLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCE---VSGVTCADGPCFNGGL 326
Query: 1423 HI--SDQGEPY-CLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECR 1479
+ +D Y C C PGF G +C++ +V R ++ + C CR
Sbjct: 327 CVGGADPDSAYICHCPPGFQGSNCEK------RVDRCSLQPCRNGGLCLDLGHALRCRCR 380
Query: 1480 GG-CGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
G GP+C + C +G + VE H C C
Sbjct: 381 AGFAGPRCEHDLDDCAGR---ACANGGTCVEGGGAH-RCSC 417
Score = 60.8 bits (146), Expect = 9e-09
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 1341 GLC-RSVEKDSV-VCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGY 1397
GLC + DS +C C PG+ G C++ D C C + G C+ G + C+C G+
Sbjct: 325 GLCVGGADPDSAYICHCPPGFQGSNCEKRV-DRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
Query: 1398 GGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
G C++ D C+ C +G + G C C GF G C++ +PC
Sbjct: 384 AGPRCEHDLDD---CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC 433
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 157 bits (397), Expect = 7e-38
Identities = 85/262 (32%), Positives = 117/262 (44%), Gaps = 42/262 (16%)
Query: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT--------------------- 958
C + +G C Q P E C C + G CTVP++T
Sbjct: 220 CRAGCSPEHGFCEQ-PGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
Query: 959 --CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
C NPC +GG+C S++ + F C+CP GF G RCE++ C D C N CV G +
Sbjct: 276 GPCDGNPCANGGSC--SETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD 332
Query: 1017 N---YVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCET 1073
Y+C CPP + G C++ +D C L C++ C+ L C C G++G CE
Sbjct: 333 PDSAYICHCPPGFQGSNCEKRVDRC--SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEH 390
Query: 1074 DNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQ 1133
D DDC C +G CV+ + C+C GF G C + PC C +G +
Sbjct: 391 DLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE-------RADPCAARPCAHGGR 443
Query: 1134 CIVVQQEPTCRCPPGFAGPRCE 1155
C C C PG+ G RCE
Sbjct: 444 CYAHFSGLVCACAPGYMGARCE 465
Score = 139 bits (349), Expect = 3e-32
Identities = 74/246 (30%), Positives = 100/246 (40%), Gaps = 20/246 (8%)
Query: 877 KEPGIARC----SSPEPMADRLLLTTPTHRFQC---KGPVDIN---IVAKCNACLSSPCK 926
++PG RC + P L T P C +GP +V C +PC
Sbjct: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
Query: 927 NNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPL 986
N G+C++ P + C CP + G C V TC PC +GG C + C CP
Sbjct: 285 NGGSCSETP-RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Query: 987 GFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQ 1046
GF+G CE D C C N C+D + C C + G C+ +D C C
Sbjct: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
Query: 1047 HEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSG 1106
+ C+ C C G+ G+ C D C A C HG +C +G C C G+ G
Sbjct: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
Query: 1107 PFCEHP 1112
CE P
Sbjct: 462 ARCEFP 467
Score = 71.6 bits (174), Expect = 5e-12
Identities = 39/106 (36%), Positives = 56/106 (52%), Gaps = 8/106 (7%)
Query: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGG 1399
GLC + ++ C CR G+ GP C+ + D C G C + G CV G ++ C CA G+GG
Sbjct: 366 GLCLDLGH-ALRCRCRAGFAGPRCEHDL-DDCAGRACANGGTCVEGGGAHRCSCALGFGG 423
Query: 1400 DLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
C + A+ C+A C H G+C+ G C C PG+ G C+
Sbjct: 424 RDC---RERADPCAARPCAHGGRCYAHFSG-LVCACAPGYMGARCE 465
Score = 67.8 bits (164), Expect = 8e-11
Identities = 46/173 (26%), Positives = 63/173 (36%), Gaps = 43/173 (24%)
Query: 1021 ICPPNYTGELCDEVIDHCVPELNLCQH----EAKCIPLDKGF-----SCECVPGYSGKLC 1071
+C P C + C P + C+ A C P + GF C C+ G++G LC
Sbjct: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSP-EHGFCEQPGECRCLEGWTGPLC 248
Query: 1072 ETDNDD-----------------------CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1108
C + C +G C +T + CTCP+GF G
Sbjct: 249 TVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLR 308
Query: 1109 CEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT---CRCPPGFAGPRCEKLI 1158
CE + C C NG C+ + C CPPGF G CEK +
Sbjct: 309 CE-------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Score = 61.6 bits (148), Expect = 6e-09
Identities = 57/221 (25%), Positives = 81/221 (36%), Gaps = 50/221 (22%)
Query: 1332 CKSCTVCK------HGLCRSVEKDSVVCECRPGWTGPLCDQEAR---------------- 1369
C++ VC+ HG C + C C GWTGPLC
Sbjct: 214 CEAPLVCRAGCSPEHGFCEQPGE----CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG 269
Query: 1370 ------DPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQC 1422
PC G+ C + G C T S+ C C G+ G C+ S C+ C +G
Sbjct: 270 CLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCE---VSGVTCADGPCFNGGL 326
Query: 1423 HI--SDQGEPY-CLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECR 1479
+ +D Y C C PGF G +C++ +V R ++ + C CR
Sbjct: 327 CVGGADPDSAYICHCPPGFQGSNCEK------RVDRCSLQPCRNGGLCLDLGHALRCRCR 380
Query: 1480 GG-CGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
G GP+C + C +G + VE H C C
Sbjct: 381 AGFAGPRCEHDLDDCAGR---ACANGGTCVEGGGAH-RCSC 417
Score = 60.8 bits (146), Expect = 9e-09
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 1341 GLC-RSVEKDSV-VCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGY 1397
GLC + DS +C C PG+ G C++ D C C + G C+ G + C+C G+
Sbjct: 325 GLCVGGADPDSAYICHCPPGFQGSNCEKRV-DRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
Query: 1398 GGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
G C++ D C+ C +G + G C C GF G C++ +PC
Sbjct: 384 AGPRCEHDLDD---CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC 433
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 154 bits (390), Expect = 5e-37
Identities = 139/553 (25%), Positives = 222/553 (40%), Gaps = 93/553 (16%)
Query: 20 LALASVLSGPPAVA----CPTKCTCSAAS----VDCHGLGLRAVPRGI--PRNAERLDLD 69
LA S+ S P ++ C + C C ++C G++ V P +L L
Sbjct: 13 LACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLL 72
Query: 70 RNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLF 129
N +T + DF+GL N +HL N ++ IE GAF L L++L +N N L++L E F
Sbjct: 73 NNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTF 132
Query: 130 QSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLN 189
L L N I I AF + +K L L++N I + FR + L L L
Sbjct: 133 HGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLR 191
Query: 190 NNNISRILVTSF-NHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGQFTLCMAPV 246
N + + F H+ +I L+L N C+C L L WL +++ +C +P
Sbjct: 192 GNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPP 251
Query: 247 HLRGFNVADVQKKEYVCPAP-----HSEP------------------------------- 270
+G ++ KKE +CP P H +P
Sbjct: 252 FFKG-SILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKA 310
Query: 271 ---------PSCNANSISCPSPCTC-----SNNIVDCRGKGLMEIP--ANLPEGIVEIRL 314
PS CP PC C S ++ C+ + + + P+ ++ L
Sbjct: 311 PGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLIL 370
Query: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
N I ++ +Y L+ + + N+I + +F L L L L GN +T+++KG+
Sbjct: 371 AGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM 430
Query: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFA---------- 424
F GL +L+ L L N I + TF + L +L L +N LQ + +F+
Sbjct: 431 FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK 490
Query: 425 --------------PLQSIQTLHLAQNPFVCDCHLKWLADYLQ--DNPIETSGARCSSPR 468
L + + L NP+ C C L L ++Q T C+SP
Sbjct: 491 TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG 550
Query: 469 RLANKRISQIKSK 481
L K + + S+
Sbjct: 551 HLDKKELKALNSE 563
Score = 129 bits (325), Expect = 2e-29
Identities = 143/604 (23%), Positives = 238/604 (39%), Gaps = 111/604 (18%)
Query: 263 CPAPHSEPPSCNANSISCPSPCTCSNN----IVDCRGKGL-----MEIPANLP------- 306
C + HS+ P ++ SC S C C +++C KG+ + +P + P
Sbjct: 15 CISLHSQTPVLSSRG-SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLN 73
Query: 307 --------------EGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQ 352
+ I L N+I I GAF LK++ I+ N + + D F
Sbjct: 74 NGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFH 133
Query: 353 GLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYD 412
GL++L L N IT I F L L++L+LN N I L N F+ + L L L
Sbjct: 134 GLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRG 192
Query: 413 NKLQTISK-GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET--SGARCSSPRR 469
N+LQT+ G + I L L N + C+C L L +L++ P ++ C+SP
Sbjct: 193 NQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPF 252
Query: 470 LANKRISQIKSKKF--------------------RCSGSEDYRSRFSSECFMDL------ 503
+S++K + S D R + + L
Sbjct: 253 FKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPG 312
Query: 504 ---------------VCPEKCRCE-----GTIVDCSNQKLVRIPSHLP--EYVTDLRLND 541
CP C C+ G ++ C + + + P + L L
Sbjct: 313 LIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAG 372
Query: 542 NEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVF 601
N + L + + + L ++L NN+I+ + EG+F +Q+L L GN L + +F
Sbjct: 373 NIIHSLMKSDLVEYF-TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMF 431
Query: 602 RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT----TLVSLST 657
GL L+ L L N I + TF + +++L L +N + + P F+ T V+L T
Sbjct: 432 LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT 491
Query: 658 --------------------INLLSNPFNCNCHLAWLGKWLRK--RRIVSGNPRCQKPFF 695
I+L NP++C+C L L +W++K + V+ + C P
Sbjct: 492 NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH 551
Query: 696 LKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVT 755
L + ++ + + C G + + T T ++ LR+L +P V
Sbjct: 552 LDKKELKALN-SEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL 610
Query: 756 ELYL 759
L L
Sbjct: 611 ILGL 614
Score = 99.0 bits (245), Expect = 3e-20
Identities = 108/442 (24%), Positives = 172/442 (38%), Gaps = 88/442 (19%)
Query: 505 CPEKCRCE---GTIVDCSNQKLVRIPSHL---PEYVTDLRLNDNEVSVLEATGIFKKLPN 558
C C CE GT++ K +++ S + P L L +N +++L T F L N
Sbjct: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH-TNDFSGLTN 89
Query: 559 LRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIG 618
I+L N I ++ GAF+G +++L + N LE + F GL L+ L +N I
Sbjct: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
Query: 619 CVSNDTFAGLSSVRLLSLYDNRITTITPGAF------------TTLVSLSTINLL----- 661
+ F+ L+ +++L L DN I ++ P F L +L + L
Sbjct: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR 209
Query: 662 -------SNPFNCNCHLAWLGKWLRKR--RIVSGNPRCQKPFFLK--------------- 697
N + CNC L L WL + + G+ C P F K
Sbjct: 210 ILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPT 269
Query: 698 -------EIPIQDV------AIQDFTCDGNEESSCQLSPRCPE----------------- 727
E P + +I D S +L + P
Sbjct: 270 PPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYC 329
Query: 728 --QCTC-----METVVRCSNKGLRALP--RGMPKDVTELYLEGNHLTAVPR-ELSALRHL 777
C C ++ C + + +L R P++ +L L GN + ++ + +L L
Sbjct: 330 PIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTL 389
Query: 778 TLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISS 837
++ L NN I +L +F N++ L L L+ N L + F GL +L L L N I
Sbjct: 390 EMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
Query: 838 VPEGSFNDLTSLSHLALGTNPL 859
+ G+FN + L L L N L
Sbjct: 450 ILPGTFNPMPKLKVLYLNNNLL 471
Score = 91.7 bits (226), Expect = 5e-18
Identities = 73/270 (27%), Positives = 120/270 (44%), Gaps = 13/270 (4%)
Query: 30 PAVACPTKCTCSAAS-----VDCHGLGLRAVP--RGIPRNAERLDLDRNNITRITKMDFA 82
P CP C C S + C + ++ R P+N +L L N I + K D
Sbjct: 325 PGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLV 384
Query: 83 GLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSE 142
L +LHL +N++ V+E G+F +L +L++L LN N L L + +F L L L
Sbjct: 385 EYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEY 444
Query: 143 NQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS-F 201
N I+ I F + +K L L+NN + + F + L + L N + + V++
Sbjct: 445 NAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNIL 503
Query: 202 NHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQ--RRTVGQFTLCMAPVHLRGFNVADVQKK 259
+ + + + L N C C L L W+++ + TV LC +P HL + +
Sbjct: 504 DDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKAL-NS 562
Query: 260 EYVCPAPHSEPPSCNANS-ISCPSPCTCSN 288
E +CP + P S + +P T +N
Sbjct: 563 EILCPGLVNNPSMPTQTSYLMVTTPATTTN 592
Score = 48.5 bits (114), Expect = 5e-05
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 3/120 (2%)
Query: 756 ELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI 814
+L++ N L + + L +L + NN I+++ FS ++ L LIL+ N + +
Sbjct: 116 QLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESL 175
Query: 815 PVHAFNGLRSLRVLTLHGNDISSVPE-GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873
P + F + L L L GN + ++P G + + L L N C+C L L W++
Sbjct: 176 PPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLE 234
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 149 bits (375), Expect = 3e-35
Identities = 117/385 (30%), Positives = 186/385 (48%), Gaps = 47/385 (12%)
Query: 18 LALALASVLSGPPAVACPTKCTCSAA--SVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75
L L L SVLSG A CP +C CSA +V CH AVP GIP LDL +N I
Sbjct: 27 LLLVLGSVLSGS-ATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
Query: 76 ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKL 135
+ + +FA +L L L +N VS +E GAF +L L L L N+L+++P +F L
Sbjct: 86 LNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145
Query: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
T+LD+SEN+I + F+ + ++K+L++ +N + I AF L LE LTL N++
Sbjct: 146 TKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTS 205
Query: 196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
I + +H+ + LRL HL ++ + D+ +R L V +
Sbjct: 206 IPTEALSHLHGLIVLRL--RHL----NINAIRDYSFKR--------------LYRLKVLE 245
Query: 256 VQKKEYVCPAPHSEPPSC----NANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 311
+ Y+ + P+C N S+S I C L +P +V
Sbjct: 246 ISHWPYL----DTMTPNCLYGLNLTSLS----------ITHC---NLTAVPYLAVRHLVY 288
Query: 312 IR---LEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT 368
+R L N I I + +L+ I + Q++ + P AF+GL L L + GN++T
Sbjct: 289 LRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLT 348
Query: 369 EIAKGLFDGLVSLQLLLLNANKINC 393
+ + +F + +L+ L+L++N + C
Sbjct: 349 TLEESVFHSVGNLETLILDSNPLAC 373
Score = 120 bits (302), Expect = 8e-27
Identities = 118/451 (26%), Positives = 187/451 (41%), Gaps = 78/451 (17%)
Query: 274 NANSISCPSPCTCS--NNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYK 331
+ ++ CP C CS + V C K + +P +P + L +N IK + F +
Sbjct: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
Query: 332 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKI 391
L+ +++++N +S + P AF L +L +L L N++ I G+F GL +L L ++ NKI
Sbjct: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
Query: 392 NCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTL-----HLAQNPFVCDCHLK 446
L FQDL NL L + DN L IS F+ L S++ L +L P HL
Sbjct: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLH 215
Query: 447 WLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCP 506
L L+ + + R S +RL ++ +I Y + C L
Sbjct: 216 GLI-VLRLRHLNINAIRDYSFKRLYRLKVLEISHWP--------YLDTMTPNCLYGLNL- 265
Query: 507 EKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSN 566
T + ++ L +P Y+ + L LR +NLS
Sbjct: 266 -------TSLSITHCNLTAVP-----YLA-----------------VRHLVYLRFLNLSY 296
Query: 567 NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFA 626
N I + +QE+ L G QL V FRGL+ L
Sbjct: 297 NPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL------------------- 337
Query: 627 GLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSG 686
R+L++ N++TT+ F ++ +L T+ L SNP C+C L W+ + +
Sbjct: 338 -----RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ 392
Query: 687 NPRCQKPFFL-----KEIPIQDVAIQD-FTC 711
P C P F+ K+ P DV + + FTC
Sbjct: 393 QPTCATPEFVQGKEFKDFP--DVLLPNYFTC 421
Score = 111 bits (277), Expect = 6e-24
Identities = 101/393 (25%), Positives = 172/393 (43%), Gaps = 83/393 (21%)
Query: 505 CPEKCRC--EGTIVDCSNQKLVRIPSHLPE------------------------YVTDLR 538
CP +C C + V C ++ V +P +P ++ +L
Sbjct: 42 CPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELE 101
Query: 539 LNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHG 598
LN+N VS +E G F L NLR + L +N++K + G F G +++ +L ++ N++ +
Sbjct: 102 LNENIVSAVEP-GAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLD 160
Query: 599 RVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTI 658
+F+ L LK+L + N + +S+ F+GL+S+ L+L +T+I A + L L +
Sbjct: 161 YMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVL 220
Query: 659 NLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESS 718
L N N + K L + +++ + P D
Sbjct: 221 RL--RHLNINAIRDYSFKRLYRLKVLE----------ISHWPYLDT-------------- 254
Query: 719 CQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLT 778
++P C L L ++T L + +LTAVP A+RHL
Sbjct: 255 --MTPNC-----------------LYGL------NLTSLSITHCNLTAVP--YLAVRHLV 287
Query: 779 ---LIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
++LS N IS + + L + L +L + +AF GL LRVL + GN +
Sbjct: 288 YLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQL 347
Query: 836 SSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWL 868
+++ E F+ + +L L L +NPL CDC L W+
Sbjct: 348 TTLEESVFHSVGNLETLILDSNPLACDCRLLWV 380
Score = 64.7 bits (156), Expect = 7e-10
Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 48/298 (16%)
Query: 64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLR-------- 115
E+L L++ N+T I + L L VL L ++ I +F+ L +L+ L
Sbjct: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD 253
Query: 116 ---------LNKNKLQV-------LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDV 159
LN L + +P L + L L+LS N I I + +
Sbjct: 254 TMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRL 313
Query: 160 KNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYC 219
+ +QL ++ +E AFR L L +L ++ N ++ + + F+ + + TL L SN L C
Sbjct: 314 QEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLAC 373
Query: 220 DCHLAWLSDWLRQRRTVGQFTLCMAPVHLRG-------------------FNVADVQKKE 260
DC L W+ + Q C P ++G + D + ++
Sbjct: 374 DCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQ 433
Query: 261 YVCPAPHSEPPSCNANSISCPSPCTCS--NNIVDCRGKGLMEIPANLPEGIVEIRLEQ 316
H+ C A+ P+ S ++V + G + + P+G +E+R Q
Sbjct: 434 VFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTV---FPDGTLEVRYAQ 488
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 142 bits (357), Expect = 3e-33
Identities = 95/278 (34%), Positives = 138/278 (49%), Gaps = 34/278 (12%)
Query: 9 GAAVRARLALALALA----SVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
G R LAL L A +V++ P CP++C C +V C L L AVP P+ +
Sbjct: 7 GPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSI 66
Query: 65 RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
LDL N I I F L+NL L L +NQ+ I GAF+DL+ L+ L L KN
Sbjct: 67 -LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN----- 120
Query: 125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLE 184
+IQ I R+AF+G+ ++ L L N I ++ +F+ L LE
Sbjct: 121 -------------------EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLE 161
Query: 185 ILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQ---FTL 241
L L+NN I+ ++ +FNH+ ++ LRL SN L+CDC + WL+D L+ G +
Sbjct: 162 RLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAI 221
Query: 242 CMAPVHLRGFNVADVQKKEYVCPAPH--SEPPSCNANS 277
C P ++G +VA + +E C P SEP + S
Sbjct: 222 CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTS 259
Score = 124 bits (310), Expect = 9e-28
Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 11/223 (4%)
Query: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPE-GIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI 338
CPS C C V C L +PA P+ I+++R N I+ I GAF + + L + +
Sbjct: 36 CPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRF--NRIREIQPGAFRRLRNLNTLLL 93
Query: 339 SKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNT 398
+ NQI I AF+ L++L L LY N+I I + F GL SL+ L L+ N+I L ++
Sbjct: 94 NNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDS 153
Query: 399 FQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQ---DN 455
FQ L L L L++N++ + G F L+S++ L L N CDC + WLAD L+ ++
Sbjct: 154 FQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAES 213
Query: 456 PIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSE 498
+ A C PRR+ + ++ I ++ C R R +SE
Sbjct: 214 GNAQAAAICEYPRRIQGRSVATITPEELNCE-----RPRITSE 251
Score = 114 bits (286), Expect = 6e-25
Identities = 68/214 (31%), Positives = 114/214 (53%), Gaps = 11/214 (5%)
Query: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEY-VTDLRLND-NEVSVLEATGIFKKLPNLRKI 562
CP +C C T V C + L +P+ P+ + DLR N E+ G F++L NL +
Sbjct: 36 CPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQ----PGAFRRLRNLNTL 91
Query: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622
L+NN+IK + GAF+ +++ L L N+++++ + F+GL+ L+ L L N I +
Sbjct: 92 LLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDP 151
Query: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRR 682
D+F L + L L++NRIT + PG F L S+ + L SN +C+C + WL L K
Sbjct: 152 DSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLAD-LLKTY 210
Query: 683 IVSGNPR----CQKPFFLKEIPIQDVAIQDFTCD 712
SGN + C+ P ++ + + ++ C+
Sbjct: 211 AESGNAQAAAICEYPRRIQGRSVATITPEELNCE 244
Score = 97.1 bits (240), Expect = 1e-19
Identities = 66/213 (30%), Positives = 96/213 (45%), Gaps = 31/213 (14%)
Query: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLS 783
CP +C C T VRC + L A+P P+ + L L N + + P LR+L + L+
Sbjct: 36 CPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLRFNRIREIQPGAFRRLRNLNTLLLN 94
Query: 784 NNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE--- 840
NN I + + F ++ +L L L N ++ I AF GL SL L LH N I ++
Sbjct: 95 NNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSF 154
Query: 841 ---------------------GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEP 879
G+FN L S+ L L +N LHCDC + WL++ +K Y E
Sbjct: 155 QHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKT-YAES 213
Query: 880 GIAR----CSSPEPMADRLLLTTPTHRFQCKGP 908
G A+ C P + R + T C+ P
Sbjct: 214 GNAQAAAICEYPRRIQGRSVATITPEELNCERP 246
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 138 bits (348), Expect = 4e-32
Identities = 79/252 (31%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 916 KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSD 974
+ + C S +G C D C C ++G C C++ P CQHG TCH
Sbjct: 25 RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMPGCQHG-TCH--- 72
Query: 975 SHKDGFSCSCPLGFEGQRCEINPDDCE-DNDCENNATCV-DGINNYVCICPPNYTGELCD 1032
+ C C G+ G+ C+ + C + C+N C+ DG Y C+C P + G C+
Sbjct: 73 ---QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
Query: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFS----CECVPGYSGKLCETDNDDCVAHKCRHGAQ 1088
C + C++ +C D+GF+ C C+ G+ G CE + DDC+ C +GA
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
Query: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148
C+D IN ++C CP+GF+G FC + C CQ GA+C + C CP G
Sbjct: 189 CLDGINRFSCLCPEGFAGRFC-------TINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
Query: 1149 FAGPRCEKLITV 1160
+ G CE ++ V
Sbjct: 242 YGGKTCELVLPV 253
Score = 67.0 bits (162), Expect = 1e-10
Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 13/119 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
C S HG C C C PGW G C++ R P C HG C + C
Sbjct: 29 CSSHCDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTC---HQPWQC 77
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
C G+ G CD S + + GQC GE +C+C PGF G C+++ PC
Sbjct: 78 ICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
Score = 54.7 bits (130), Expect = 7e-07
Identities = 40/136 (29%), Positives = 53/136 (38%), Gaps = 18/136 (13%)
Query: 1322 PPQSLGVSPG-----CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL 1373
P S PG C+ C C+HG C + C C GW G CD++
Sbjct: 42 PDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTT 97
Query: 1374 GHRCHHG-KCVATGTS-YMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY 1431
C +G +C+ G Y C C G+ G C+ K + + GQC DQG
Sbjct: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ-DDQGFAL 156
Query: 1432 ---CLCQPGFSGEHCQ 1444
C C GF G C+
Sbjct: 157 NFTCRCLVGFVGARCE 172
Score = 48.1 bits (113), Expect = 6e-05
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCKCAEGYGGDLCDNKNDSANA 1411
C C G+ G C+ D CL C +G G + + C C EG+ G C D
Sbjct: 160 CRCLVGFVGARCEVNV-DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD--- 215
Query: 1412 CSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444
C++ C G D+ + CLC G+ G+ C+
Sbjct: 216 CASRPCQRG-ARCRDRVHDFDCLCPSGYGGKTCE 248
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 138 bits (348), Expect = 4e-32
Identities = 79/252 (31%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 916 KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSD 974
+ + C S +G C D C C ++G C C++ P CQHG TCH
Sbjct: 25 RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMPGCQHG-TCH--- 72
Query: 975 SHKDGFSCSCPLGFEGQRCEINPDDCE-DNDCENNATCV-DGINNYVCICPPNYTGELCD 1032
+ C C G+ G+ C+ + C + C+N C+ DG Y C+C P + G C+
Sbjct: 73 ---QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
Query: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFS----CECVPGYSGKLCETDNDDCVAHKCRHGAQ 1088
C + C++ +C D+GF+ C C+ G+ G CE + DDC+ C +GA
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
Query: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148
C+D IN ++C CP+GF+G FC + C CQ GA+C + C CP G
Sbjct: 189 CLDGINRFSCLCPEGFAGRFC-------TINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
Query: 1149 FAGPRCEKLITV 1160
+ G CE ++ V
Sbjct: 242 YGGKTCELVLPV 253
Score = 67.0 bits (162), Expect = 1e-10
Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 13/119 (10%)
Query: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
C S HG C C C PGW G C++ R P C HG C + C
Sbjct: 29 CSSHCDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTC---HQPWQC 77
Query: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
C G+ G CD S + + GQC GE +C+C PGF G C+++ PC
Sbjct: 78 ICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
Score = 54.7 bits (130), Expect = 7e-07
Identities = 40/136 (29%), Positives = 53/136 (38%), Gaps = 18/136 (13%)
Query: 1322 PPQSLGVSPG-----CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL 1373
P S PG C+ C C+HG C + C C GW G CD++
Sbjct: 42 PDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTT 97
Query: 1374 GHRCHHG-KCVATGTS-YMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY 1431
C +G +C+ G Y C C G+ G C+ K + + GQC DQG
Sbjct: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ-DDQGFAL 156
Query: 1432 ---CLCQPGFSGEHCQ 1444
C C GF G C+
Sbjct: 157 NFTCRCLVGFVGARCE 172
Score = 48.1 bits (113), Expect = 6e-05
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCKCAEGYGGDLCDNKNDSANA 1411
C C G+ G C+ D CL C +G G + + C C EG+ G C D
Sbjct: 160 CRCLVGFVGARCEVNV-DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD--- 215
Query: 1412 CSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444
C++ C G D+ + CLC G+ G+ C+
Sbjct: 216 CASRPCQRG-ARCRDRVHDFDCLCPSGYGGKTCE 248
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 138 bits (348), Expect = 4e-32
Identities = 119/437 (27%), Positives = 182/437 (41%), Gaps = 60/437 (13%)
Query: 953 TVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012
+V ++C+ PCQ+GG+C +R ++
Sbjct: 3800 SVDHDSCVHGPCQNGGSCL-------------------RRLAVSSVLKSRESLPVIIVAN 3840
Query: 1013 DGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
+ + ++C C P Y G C+ ID C+P + C C L GFSC C G++G+ CE
Sbjct: 3841 EPLQPFLCKCLPGYAGSWCEIDIDECLP--SPCHSGGTCHNLVGGFSCSCPDGFTGRACE 3898
Query: 1073 TDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132
D ++C+ C++GA C + + C C G++G CE + C+ C NG
Sbjct: 3899 RDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCES-------SVNYCECNPCFNGG 3951
Query: 1133 QCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKD--SYVELASAKVRPQAN-ISLQVATD 1189
C C CP G G CE +N G + SY+E S + P N I ++ AT
Sbjct: 3952 SCQSGVDSYYCHCPFGVFGKHCE----LNSYGFEELSYMEFPS--LDPNNNYIYVKFATI 4005
Query: 1190 KDNGILLYKGDNDP------LALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVEL 1243
K + +LLY DN LALE+ + +R Y +L S + +++ V+DG FH+V
Sbjct: 4006 KSHALLLYNYDNQTGDRAEFLALEIAEERLRFSY-NLGSGTYKLTTMKKVSDGHFHTVIA 4064
Query: 1244 VTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIP---TSTGLSALRQGTDR--- 1297
+L VD + V ++ L P T G+ +L R
Sbjct: 4065 RRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGH 4124
Query: 1298 -PLGGFHGCIHEVRINNE-LQDFKALPPQSLGVSPGCK----SCT--VCKHGLCRSVEKD 1349
F GCI E +N L+ +AL Q G+ C +CT C+HG
Sbjct: 4125 VESHDFVGCIMEFAVNGRPLEPSQALAAQ--GILDQCPRLEGACTRSPCQHGGTCMDYWS 4182
Query: 1350 SVVCECRPGWTGPLCDQ 1366
C C+ G TG C++
Sbjct: 4183 WQQCHCKEGLTGKYCEK 4199
Score = 119 bits (299), Expect = 2e-26
Identities = 56/179 (31%), Positives = 91/179 (50%), Gaps = 26/179 (14%)
Query: 918 NACLSSPCKNNGTCTQ---------------------DPVELYRCACPYSYKGKDCTVPI 956
++C+ PC+N G+C + +P++ + C C Y G C + I
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 957 NTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
+ C+ +PC GGTCH + GFSCSCP GF G+ CE + ++C + C+N A C +
Sbjct: 3864 DECLPSPCHSGGTCH---NLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPG 3920
Query: 1017 NYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN 1075
++ C+C YTG++C+ +++C E N C + C + C C G GK CE ++
Sbjct: 3921 SFNCVCKTGYTGKMCESSVNYC--ECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNS 3977
Score = 59.3 bits (142), Expect = 3e-08
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 11/105 (10%)
Query: 1352 VCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEGYGGDLCDNKNDSAN 1410
+C+C PG+ G C+ + D CL CH G C + C C +G+ G C+ N
Sbjct: 3847 LCKCLPGYAGSWCEIDI-DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACER---DIN 3902
Query: 1411 ACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE------NPC 1449
C C +G + G C+C+ G++G+ C+ NPC
Sbjct: 3903 ECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPC 3947
Score = 58.2 bits (139), Expect = 6e-08
Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 5/93 (5%)
Query: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGGDLCDNKNDSANA 1411
C C G+TG C+++ + CL C +G C S+ C C GY G +C++ S N
Sbjct: 3886 CSCPDGFTGRACERDINE-CLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCES---SVNY 3941
Query: 1412 CSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
C C +G S YC C G G+HC+
Sbjct: 3942 CECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 53.5 bits (127), Expect = 2e-06
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 24/99 (24%)
Query: 897 TTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPI 956
T P+ + C+GP N C S+PC + C YRC VP
Sbjct: 4390 TDPSVKIGCRGP---------NICASNPCWGDLLCINQWYA-YRC------------VPP 4427
Query: 957 NTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEI 995
C +PCQ+GG+C GF+CSCP G+ CE+
Sbjct: 4428 GDCASHPCQNGGSCE--PGLHSGFTCSCPDSHTGRTCEM 4464
Score = 52.0 bits (123), Expect = 4e-06
Identities = 76/348 (21%), Positives = 124/348 (35%), Gaps = 52/348 (14%)
Query: 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLIT----VNFVGK---DSYV------ 1169
C + CQ+G C+ C C G G CEK +T ++ GK D ++
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKR 4225
Query: 1170 ------ELASAKVRPQANISLQV--ATDKDNGILLY-KGDNDPLALELYQGHVRLVYDS- 1219
L A + P SL+V T +NG+L++ + ++ +++ G V D+
Sbjct: 4226 EYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVYFTSDAG 4285
Query: 1220 LSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGIN-SPLY 1278
++ V DG +H+ + L VD+ + + Q G++ +
Sbjct: 4286 IAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIH-PTQDFGGLDVLTIS 4344
Query: 1279 LGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFK------ALPPQSLGVSPGC 1332
LGGIP + + D GF GCI + E F ++ V GC
Sbjct: 4345 LGGIPPN------QAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGC 4398
Query: 1333 KSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATG--TSYM 1390
+ +C C D + C W C C H C +G G + +
Sbjct: 4399 RGPNICASNPCWG---DLL---CINQWYAYRCVPPG--DCASHPCQNGGSCEPGLHSGFT 4450
Query: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQ-CHISDQGEPYCLCQPG 1437
C C + + G C + AC C G+ C C+ G
Sbjct: 4451 CSCPDSHTGRTC----EMVVACLGVLCPQGKVCKAGSPAGHVCVLSQG 4494
Score = 47.4 bits (111), Expect = 1e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 13/99 (13%)
Query: 872 VKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTC 931
VK G + P I C+S P LL + ++C P D C S PC+N G+C
Sbjct: 4394 VKIGCRGPNI--CAS-NPCWGDLLCINQWYAYRCVPPGD---------CASHPCQNGGSC 4441
Query: 932 TQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTC 970
+ C+CP S+ G+ C + + C+ C G C
Sbjct: 4442 EPGLHSGFTCSCPDSHTGRTCEMVV-ACLGVLCPQGKVC 4479
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/110 (23%), Positives = 42/110 (38%), Gaps = 29/110 (26%)
Query: 1069 KLCETDNDDCVAHKCRHGAQCV----------------------DTINGYTCTCPQGFSG 1106
K+ D+D CV C++G C+ + + + C C G++G
Sbjct: 3797 KVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAG 3856
Query: 1107 PFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEK 1156
+CE + C C +G C + +C CP GF G CE+
Sbjct: 3857 SWCE-------IDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACER 3899
Score = 43.5 bits (101), Expect = 0.002
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 16/80 (20%)
Query: 957 NTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
N C NPC C + RC + P DC + C+N +C G++
Sbjct: 4402 NICASNPCWG--------------DLLCINQWYAYRC-VPPGDCASHPCQNGGSCEPGLH 4446
Query: 1017 N-YVCICPPNYTGELCDEVI 1035
+ + C CP ++TG C+ V+
Sbjct: 4447 SGFTCSCPDSHTGRTCEMVV 4466
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 6/64 (9%)
Query: 1389 YMCKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGEHCQQE- 1446
++CKC GY G C+ D C CH G CH + G C C GF+G C+++
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDE---CLPSPCHSGGTCH-NLVGGFSCSCPDGFTGRACERDI 3901
Query: 1447 NPCL 1450
N CL
Sbjct: 3902 NECL 3905
Score = 42.4 bits (98), Expect = 0.003
Identities = 28/109 (25%), Positives = 43/109 (39%), Gaps = 17/109 (15%)
Query: 997 PDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIP-LD 1055
P+ C N C + C++ Y C+ P + + CQ+ C P L
Sbjct: 4401 PNICASNPCWGDLLCINQWYAYRCVPPGDCAS--------------HPCQNGGSCEPGLH 4446
Query: 1056 KGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQC-VDTINGYTCTCPQG 1103
GF+C C ++G+ CE C+ C G C + G+ C QG
Sbjct: 4447 SGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAGSPAGHVCVLSQG 4494
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 13/69 (18%)
Query: 1043 NLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN-GYTCTCP 1101
N C + CI ++ ++ CVP DC +H C++G C ++ G+TC+CP
Sbjct: 4407 NPCWGDLLCI--NQWYAYRCVPP----------GDCASHPCQNGGSCEPGLHSGFTCSCP 4454
Query: 1102 QGFSGPFCE 1110
+G CE
Sbjct: 4455 DSHTGRTCE 4463
Score = 36.6 bits (83), Expect = 0.19
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
Query: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCE--INPD 998
C ++PCQHGGTC + C C G G+ CE + PD
Sbjct: 4166 CTRSPCQHGGTCM---DYWSWQQCHCKEGLTGKYCEKSVTPD 4204
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 137 bits (346), Expect = 6e-32
Identities = 83/272 (30%), Positives = 138/272 (50%), Gaps = 21/272 (7%)
Query: 16 LALALALASVLSGPPAVACPTKCTC-SAASVDCHGLGLRAVPRGIPRNAERLDLDRNNIT 74
L ++ A+ +++ P ACP +C C V C L ++P IP N ER++L N++
Sbjct: 11 LLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLV 70
Query: 75 RITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPK 134
R+ + DF+GL L +L L N + I F DL+ L+ L+++ NK++ L + F
Sbjct: 71 RLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRS 130
Query: 135 LTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEI--------L 186
LTRL + N I+ I + F G+ ++ + L+ N ++ + F +L L+I L
Sbjct: 131 LTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFL 190
Query: 187 TLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTV---------- 236
L++N ++ + ++MP + +L LH N CDCHL WLSDW++++ V
Sbjct: 191 YLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPS 250
Query: 237 --GQFTLCMAPVHLRGFNVADVQKKEYVCPAP 266
Q LCM P +G +A V + C P
Sbjct: 251 SAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKP 282
Score = 101 bits (252), Expect = 5e-21
Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 45/253 (17%)
Query: 279 SCPSPCTC-SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNS------------------- 318
+CP C C V C + L IP ++P + I L NS
Sbjct: 28 ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLM 87
Query: 319 -----IKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKG 373
I IP F+ + L+ + +S N++ + D F GL+SLT L + N I I
Sbjct: 88 LHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPE 147
Query: 374 LFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNL--------LSLYDNKLQTISKGLFAP 425
+F GL L+L+ L N++ L +TF L L + L L DN L ++ + + +
Sbjct: 148 VFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSY 207
Query: 426 LQSIQTLHLAQNPFVCDCHLKWLADYLQDNP--IETSGAR----------CSSPRRLANK 473
+ + +L+L NP+ CDCHLKWL+D++Q+ P I+ R C +PR K
Sbjct: 208 MPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGK 267
Query: 474 RISQIKSKKFRCS 486
++ + + F+C+
Sbjct: 268 PLAMVSAAAFQCA 280
Score = 92.0 bits (227), Expect = 4e-18
Identities = 67/251 (26%), Positives = 111/251 (44%), Gaps = 44/251 (17%)
Query: 505 CPEKCRCE-GTIVDCSNQKLVRIPSHLPEYVTDLRLNDN----------------EVSVL 547
CP +C C T V C+ + L IP +P V + L N E+ +L
Sbjct: 29 CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLML 88
Query: 548 EATGI-------FKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV 600
+ GI F L L+ + +S NK++++++ F G S+ L + N +E ++ V
Sbjct: 89 HSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEV 148
Query: 601 FRGLSGLKTLMLRSNLIGCVSNDTFAGL--------SSVRLLSLYDNRITTITPGAFTTL 652
F GL+ L+ + L N + + DTF L S ++ L L DN +T++ + +
Sbjct: 149 FYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYM 208
Query: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRKRRIV------------SGNPRCQKPFFLKEIP 700
L ++ L NP+ C+CHL WL W++++ V P C P K P
Sbjct: 209 PDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKP 268
Query: 701 IQDVAIQDFTC 711
+ V+ F C
Sbjct: 269 LAMVSAAAFQC 279
Score = 79.3 bits (194), Expect = 3e-14
Identities = 66/266 (24%), Positives = 108/266 (40%), Gaps = 77/266 (28%)
Query: 725 CPEQCTC-METVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDL 782
CP +C C M T V C+ + L ++P +P +V + L N L + + S L L L+ L
Sbjct: 29 CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLML 88
Query: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRS------------------ 824
+N I + + TFS++ L L +SYN++R + F GLRS
Sbjct: 89 HSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEV 148
Query: 825 ------LRVLTLHGND--------------------------------ISSVPEGSFNDL 846
LR++ L GN ++S+P+ + +
Sbjct: 149 FYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYM 208
Query: 847 TSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCS---------------SPEPMA 891
L L L NP CDC L+WLS+W++ ++P + +C +P
Sbjct: 209 PDLDSLYLHGNPWTCDCHLKWLSDWIQ---EKPDVIKCKKDRSPSSAQQCPLCMNPRTSK 265
Query: 892 DRLLLTTPTHRFQCKGP-VDINIVAK 916
+ L FQC P +D ++ +K
Sbjct: 266 GKPLAMVSAAAFQCAKPTIDSSLKSK 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,470,855
Number of Sequences: 37866
Number of extensions: 3322552
Number of successful extensions: 24796
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 375
Number of HSP's successfully gapped in prelim test: 337
Number of HSP's that attempted gapping in prelim test: 7447
Number of HSP's gapped (non-prelim): 7319
length of query: 1523
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1408
effective length of database: 13,892,928
effective search space: 19561242624
effective search space used: 19561242624
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.