Search of human proteins with 105990539

Search of human proteins with 105990539

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|105990539 neurofilament, light polypeptide 68kDa [Homo
sapiens]
         (543 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]   1029   0.0  
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...   403   e-112
gi|14249342 internexin neuronal intermediate filament protein, a...   397   e-110
gi|62414289 vimentin [Homo sapiens]                                   355   6e-98
gi|55749932 desmin [Homo sapiens]                                     348   5e-96
gi|21264345 peripherin [Homo sapiens]                                 337   1e-92
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap...   318   1e-86
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]   318   1e-86
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    305   9e-83
gi|4504919 keratin 8 [Homo sapiens]                                   243   4e-64
gi|67782365 keratin 7 [Homo sapiens]                                  232   7e-61
gi|119395754 keratin 5 [Homo sapiens]                                 230   3e-60
gi|5031839 keratin 6A [Homo sapiens]                                  226   3e-59
gi|155969697 keratin 6C [Homo sapiens]                                226   5e-59
gi|119703753 keratin 6B [Homo sapiens]                                224   2e-58
gi|153791158 keratin 75 [Homo sapiens]                                223   3e-58
gi|15431316 keratin, hair, basic, 4 [Homo sapiens]                    221   1e-57
gi|153791670 keratin 76 [Homo sapiens]                                214   2e-55
gi|4504935 keratin 85 [Homo sapiens]                                  214   2e-55
gi|28173564 keratin 73 [Homo sapiens]                                 213   4e-55
gi|109148552 keratin 3 [Homo sapiens]                                 212   6e-55
gi|109255249 keratin 4 [Homo sapiens]                                 212   8e-55
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap...   211   1e-54
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap...   211   1e-54
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap...   211   1e-54
gi|14318422 keratin 86 [Homo sapiens]                                 211   1e-54
gi|169790853 keratin, hair, basic, 1 [Homo sapiens]                   208   9e-54
gi|169790841 keratin 83 [Homo sapiens]                                207   2e-53
gi|119395750 keratin 1 [Homo sapiens]                                 207   3e-53
gi|27477127 keratin 82 [Homo sapiens]                                 203   3e-52

>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
          Length = 543

 Score = 1029 bits (2661), Expect = 0.0
 Identities = 543/543 (100%), Positives = 543/543 (100%)

Query: 1   MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSS 60
           MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSS
Sbjct: 1   MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSS 60

Query: 61  SGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEA 120
           SGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEA
Sbjct: 61  SGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEA 120

Query: 121 ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEE 180
           ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEE
Sbjct: 121 ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEE 180

Query: 181 EVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQY 240
           EVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQY
Sbjct: 181 EVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQY 240

Query: 241 AQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300
           AQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA
Sbjct: 241 AQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300

Query: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360
           AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT
Sbjct: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360

Query: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFG 420
           TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFG
Sbjct: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFG 420

Query: 421 RSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEE 480
           RSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEE
Sbjct: 421 RSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEE 480

Query: 481 KDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAK 540
           KDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAK
Sbjct: 481 KDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAK 540

Query: 541 KKD 543
           KKD
Sbjct: 541 KKD 543


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score =  403 bits (1036), Expect = e-112
 Identities = 245/563 (43%), Positives = 352/563 (62%), Gaps = 24/563 (4%)

Query: 3   SFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTA-RSAYSSYSAPVSSSLSVRRSYSS-- 59
           S++ +   + S  RR  ET R   S V    S+  RS   S  +P + S S +RS  +  
Sbjct: 2   SYTLDSLGNPSAYRRVTET-RSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR 60

Query: 60  ---SSGSLMPSLENLDLSQVAAISN-------DLKSIRTQEKAQLQDLNDRFASFIERVH 109
              SS  L  +  +LD SQ +++ N       D K  R+ EK QLQ LNDRFA +IE+VH
Sbjct: 61  LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH 120

Query: 110 ELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEE 169
            LEQQNK +EAE+  LRQK +  ++    Y+QEIR+LR   E   +EK  +Q + + LEE
Sbjct: 121 YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE 180

Query: 170 TLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEE 229
            +  L+ R+EEE   R+D E  +   RK  +EA+L + EL+K++ SL DE++FL+  HEE
Sbjct: 181 DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE 240

Query: 230 EIAELQAQIQYAQISVEM-DVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLT 288
           E+A+L AQIQ + I+VE  D  K D+S ALK+IR+Q E  + +NM  AEEWFK R+  LT
Sbjct: 241 EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT 300

Query: 289 ESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQ 348
           E+A +N +A+R+AK+E++E RR L++K++E+E+ RG  E+LE+QL ++E++ N D+S+ Q
Sbjct: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ 360

Query: 349 DTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSI 408
           DTI +LENELR TK EMAR+L+EYQDLLNVKMALDIEIAAYRKLLEGEETR S T  GSI
Sbjct: 361 DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS-TFAGSI 419

Query: 409 TSG-YSQSSQVFGRSAYGGLQTSSYLMSTRS---FPSYYTSHVQEEQIEVEETIEAAKAE 464
           T   Y+    +   S     +  +  +  +          + V++E+ E+EE + A   E
Sbjct: 420 TGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEE 479

Query: 465 EAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAE 524
            A      + EA EE++++ EAEEEE A ++   K  + E KEEE   E EEG+E +E E
Sbjct: 480 LAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE 539

Query: 525 EE----EKKVEGAGEEQAAKKKD 543
           +E    ++  EG  E++ + +K+
Sbjct: 540 DEGAKSDQAEEGGSEKEGSSEKE 562



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 98/495 (19%), Positives = 193/495 (38%), Gaps = 68/495 (13%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           IS  LK IR+Q    L+  +D      + +H+ E+  K   A+L    +++ E  R    
Sbjct: 266 ISTALKEIRSQ----LESHSD------QNMHQAEEWFKCRYAKLTEAAEQNKEAIRSA-- 313

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
            ++EI + R   +  + E ++++G +E LE  L +++ R+  ++ S +D   +L    +G
Sbjct: 314 -KEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRG 372

Query: 199 AD-EAALARAELEKRIDSLMD---EISFLKKVHEEEIAELQA---------QIQYAQISV 245
              E A    E +  ++  M    EI+  +K+ E E                     I++
Sbjct: 373 TKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITI 432

Query: 246 EMDVTKPDLSAALKDIRAQY--EKLAAKNMQNAEEWFKSRFTVLTE------------SA 291
              + KP + A    ++ ++  E +    +++ +   +   T +TE            +A
Sbjct: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAA 492

Query: 292 AKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTI 351
            +  +   A ++EV+  +  +KA   E++   G  E  E Q +E E+ + A     ++  
Sbjct: 493 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 552

Query: 352 NKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTS-VGSITS 410
           ++ E      + E      E +                    EGEE        V   + 
Sbjct: 553 SEKEGSSEKEEGEQEEGETEAE-------------------AEGEEAEAKEEKKVEEKSE 593

Query: 411 GYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVE--ETIEAAKAEEAKD 468
             +   ++   +     + +   +          S V +  +E +    +  +  EE   
Sbjct: 594 EVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 653

Query: 469 EPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEK 528
            P  +   EE+ K        E   +    K   EEAK + E G+GE      + EEEEK
Sbjct: 654 SPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE------QKEEEEK 707

Query: 529 KVEGAGEEQAAKKKD 543
           +V+ A +E+  +KK+
Sbjct: 708 EVKEAPKEEKVEKKE 722



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 33/123 (26%)

Query: 448 QEEQIEVEETIEAAKAEEAKDEP---PSEGEAEEEEKDKEEAE------------EEEAA 492
           +EE+ EV+E  +  K E+ +++P   P + +AE   K++  AE            E+E  
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 762

Query: 493 EEEEAAKEESEEAKEEEEGGEGEEGE------------------ETKEAEEEEKKVEGAG 534
           EE +  ++E E+ K   EGG  EEG                   E KE  E+E K +G+G
Sbjct: 763 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 822

Query: 535 EEQ 537
            E+
Sbjct: 823 REE 825



 Score = 30.8 bits (68), Expect = 3.3
 Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 1/87 (1%)

Query: 455 EETIEAAKAEEAKDEPPSEGEAE-EEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGE 513
           EE  +       K++    GE E +EE ++E  E+    EEE+       +    +E   
Sbjct: 785 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 844

Query: 514 GEEGEETKEAEEEEKKVEGAGEEQAAK 540
           G++ EE     +  +K+   G + A K
Sbjct: 845 GDKSEEKVVVTKTVEKITSEGGDGATK 871


>gi|14249342 internexin neuronal intermediate filament protein,
           alpha [Homo sapiens]
          Length = 499

 Score =  397 bits (1021), Expect = e-110
 Identities = 237/487 (48%), Positives = 325/487 (66%), Gaps = 26/487 (5%)

Query: 3   SFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSG 62
           SF  E Y  +S   R V      +S+  SG   A   + S S   S+  S     S+SS 
Sbjct: 2   SFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGA-GGFRSQSLSRSNVASSAACSSASSL 60

Query: 63  SL------MPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNK 116
            L       P+ + LDLSQ AA +N+ K IRT EK QLQ LNDRFA FIE+VH+LE QN+
Sbjct: 61  GLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120

Query: 117 VLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQA 176
            LEAEL  LRQ+H+EPSR   L+++E+RDLR   E+A++ +     ER+GL E ++ L+A
Sbjct: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180

Query: 177 RYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQA 236
           R EEE   RE AE  L   ++  D A LAR +LEK+++SL+DE++F+++VH+EE+AEL A
Sbjct: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240

Query: 237 QIQYA-QISVEMDVT--KPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAK 293
            +Q + Q + E+DVT  KPDL++AL++IRAQYE LAAKN+Q+AEEW+KS+F  L E AA+
Sbjct: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300

Query: 294 NTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINK 353
           +T+A+RA+++E+ E RR L+A+T+EIE  RG NE+LE+Q+ ELE++ +A+++  QD+I +
Sbjct: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360

Query: 354 LENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYS 413
           LEN+LR TKSEMAR+L+EYQDLLNVKMALDIEIAAYRKLLEGEETR S       TSG S
Sbjct: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS-------TSGLS 413

Query: 414 QSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSE 473
                   S    L   SYL+  R   S  TS V    + +++  E  +A +   +  S+
Sbjct: 414 -------ISGLNPLPNPSYLLPPRIL-SATTSKVSSTGLSLKKEEEEEEASKVASKKTSQ 465

Query: 474 -GEAEEE 479
            GE+ EE
Sbjct: 466 IGESFEE 472


>gi|62414289 vimentin [Homo sapiens]
          Length = 466

 Score =  355 bits (911), Expect = 6e-98
 Identities = 190/390 (48%), Positives = 273/390 (70%), Gaps = 3/390 (0%)

Query: 13  SYKRRYVETP-RVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENL 71
           S  R YV T  R +        ST+RS Y+S    V ++ S      SS   +    +++
Sbjct: 25  SSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSV 84

Query: 72  DLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSE 131
           D S   AI+ + K+ RT EK +LQ+LNDRFA++I++V  LEQQNK+L AEL  L  K   
Sbjct: 85  DFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQL--KGQG 142

Query: 132 PSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGR 191
            SR   LYE+E+R+LR   +  TN+K  ++ ER+ L E +  L+ + +EE+L RE+AE  
Sbjct: 143 KSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENT 202

Query: 192 LMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTK 251
           L   R+  D A+LAR +LE++++SL +EI+FLKK+HEEEI ELQAQIQ   + +++DV+K
Sbjct: 203 LQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSK 262

Query: 252 PDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRL 311
           PDL+AAL+D+R QYE +AAKN+Q AEEW+KS+F  L+E+A +N DA+R AK E +E RR 
Sbjct: 263 PDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQ 322

Query: 312 LKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKE 371
           +++ T E++A +G NE+LE+Q++E+E+    + +  QDTI +L++E++  K EMAR+L+E
Sbjct: 323 VQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLRE 382

Query: 372 YQDLLNVKMALDIEIAAYRKLLEGEETRLS 401
           YQDLLNVKMALDIEIA YRKLLEGEE+R+S
Sbjct: 383 YQDLLNVKMALDIEIATYRKLLEGEESRIS 412


>gi|55749932 desmin [Homo sapiens]
          Length = 470

 Score =  348 bits (894), Expect = 5e-96
 Identities = 204/458 (44%), Positives = 283/458 (61%), Gaps = 29/458 (6%)

Query: 22  PRVHISSVRSGYSTARSAY----SSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVA 77
           PR    S  S  S     Y    +S  A    SL   R  ++ + S   + E LD S   
Sbjct: 36  PRAGFGSKGSSSSVTSRVYQVSRTSGGAGGLGSLRASRLGTTRTPSSYGAGELLDFSLAD 95

Query: 78  AISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRA 137
           A++ +  + RT EK +LQ+LNDRFA++IE+V  LEQQN  L AE  V R K  EP+R   
Sbjct: 96  AVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAE--VNRLKGREPTRVAE 153

Query: 138 LYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARK 197
           LYE+E+R+LR   E  TN++  +  ER+ L + L+ L+A+ +EE+  +E+AE  L   R 
Sbjct: 154 LYEEELRELRRQVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRA 213

Query: 198 GADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAA 257
             D A LAR +LE+RI+SL +EI+FLKKVHEEEI ELQAQ+Q  Q+ VEMD++KPDL+AA
Sbjct: 214 DVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAA 273

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           L+DIRAQYE +AAKN+  AEEW+KS+ + LT++A KN DA+R AK E+ E R  +++ T 
Sbjct: 274 LRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTC 333

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           EI+A +G N++L +Q++ELED+  ++ S  QD I +LE E+R  K EMAR+L+EYQDLLN
Sbjct: 334 EIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLN 393

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTR 437
           VKMALD+EIA YRKLLEGEE+R++                         +QT S L    
Sbjct: 394 VKMALDVEIATYRKLLEGEESRINLP-----------------------IQTYSALNFRE 430

Query: 438 SFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGE 475
           + P    S V  ++  + +TIE    E   +    + E
Sbjct: 431 TSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHE 468


>gi|21264345 peripherin [Homo sapiens]
          Length = 470

 Score =  337 bits (865), Expect = 1e-92
 Identities = 197/401 (49%), Positives = 273/401 (68%), Gaps = 12/401 (2%)

Query: 9   YYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVR----RSYSSSSGSL 64
           + STSY+R +   P +   +  S  S++R + S      S S SVR    RS  + +G+L
Sbjct: 12  FSSTSYRRTFGPPPSLSPGAF-SYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGAL 70

Query: 65  M--PSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAEL 122
           +  PS E LD S   A++ +  + R+ EK +LQ+LNDRFA+FIE+V  LEQQN  L  EL
Sbjct: 71  LRLPS-ERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGEL 129

Query: 123 LVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEV 182
              R +  EP+R   L +QE+R+LR   E    E+  +Q ER+GL E L  L+ R EEE 
Sbjct: 130 SQARGQ--EPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEET 187

Query: 183 LSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQ 242
             REDAE  L+  RK  D+A L+R ELE++I+SLMDEI FLKK+HEEE+ +LQ  ++  Q
Sbjct: 188 RKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQ 247

Query: 243 IS-VEMDVT-KPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300
           +  VE++ T KP+L+AAL+DIRAQYE +AAKN+Q AEEW+KS++  L+++A +N +A+R 
Sbjct: 248 VQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQ 307

Query: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360
           AK E++ESRR +++ T E++  RG NEAL +QL+ELE++   +    Q    +LE ELR 
Sbjct: 308 AKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQ 367

Query: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLS 401
            K EMAR+L+EYQ+LLNVKMALDIEIA YRKLLEGEE+R+S
Sbjct: 368 LKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRIS 408


>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
           sapiens]
          Length = 431

 Score =  318 bits (814), Expect = 1e-86
 Identities = 171/373 (45%), Positives = 250/373 (67%), Gaps = 7/373 (1%)

Query: 34  STARSAYSSYSAPVSSSLSVRRSYSS----SSGSLMPSLEN-LDLSQVAAISNDLKSIRT 88
           S AR +Y S    +   L+  R        S   + P L   +D S   A++   K  R 
Sbjct: 8   SAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRA 67

Query: 89  QEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRL 148
            E+A++ +LNDRFAS+IE+V  LEQQNK L AEL  LR K  EP++   +Y+ E+R+LRL
Sbjct: 68  SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKLADVYQAELRELRL 125

Query: 149 AAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAE 208
             +  T     L+ ER+ L + L  ++ + ++E   R +AE  L   R+ ADEA LAR +
Sbjct: 126 RLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLD 185

Query: 209 LEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKL 268
           LE++I+SL +EI FL+K+HEEE+ ELQ Q+   Q+ VE+DV KPDL+AALK+IR QYE +
Sbjct: 186 LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245

Query: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEA 328
           A+ NM  AEEW++S+F  LT++AA+N + +R AK E ++ RR L++ T ++E+ RG NE+
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305

Query: 329 LEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAA 388
           LE+Q++E E++   + ++ Q+ + +LE E ++ K EMAR+L+EYQDLLNVK+ALDIEIA 
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365

Query: 389 YRKLLEGEETRLS 401
           YRKLLEGEE R++
Sbjct: 366 YRKLLEGEENRIT 378



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 62/310 (20%), Positives = 131/310 (42%), Gaps = 52/310 (16%)

Query: 208 ELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEK 267
           EL  R  S ++++ FL++ ++   AEL  Q++  + +   DV +    A L+++R + ++
Sbjct: 75  ELNDRFASYIEKVRFLEQQNKALAAELN-QLRAKEPTKLADVYQ----AELRELRLRLDQ 129

Query: 268 LAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNE 327
           L A +         +R  V  ++ A++   VR         ++L     L +EA      
Sbjct: 130 LTANS---------ARLEVERDNLAQDLATVR---------QKLQDETNLRLEA----EN 167

Query: 328 ALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQD-LLNVKMALDIEI 386
            L    QE ++   A +  ++  I  LE E+R  +      ++E Q+ L   ++ +++++
Sbjct: 168 NLAAYRQEADEATLARLD-LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDV 226

Query: 387 AAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL-----QTSSYLMSTRSFPS 441
           A        +E R   T   ++ S     ++ + RS +  L     + +  L   +   +
Sbjct: 227 AKPDLTAALKEIR---TQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEAN 283

Query: 442 YYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEA---A 498
            Y   +Q    ++E      ++             E + +++EE    EAA  +EA    
Sbjct: 284 DYRRQLQSLTCDLESLRGTNES------------LERQMREQEERHVREAASYQEALARL 331

Query: 499 KEESEEAKEE 508
           +EE +  K+E
Sbjct: 332 EEEGQSLKDE 341


>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
          Length = 432

 Score =  318 bits (814), Expect = 1e-86
 Identities = 171/373 (45%), Positives = 250/373 (67%), Gaps = 7/373 (1%)

Query: 34  STARSAYSSYSAPVSSSLSVRRSYSS----SSGSLMPSLEN-LDLSQVAAISNDLKSIRT 88
           S AR +Y S    +   L+  R        S   + P L   +D S   A++   K  R 
Sbjct: 8   SAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRA 67

Query: 89  QEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRL 148
            E+A++ +LNDRFAS+IE+V  LEQQNK L AEL  LR K  EP++   +Y+ E+R+LRL
Sbjct: 68  SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKLADVYQAELRELRL 125

Query: 149 AAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAE 208
             +  T     L+ ER+ L + L  ++ + ++E   R +AE  L   R+ ADEA LAR +
Sbjct: 126 RLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLD 185

Query: 209 LEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKL 268
           LE++I+SL +EI FL+K+HEEE+ ELQ Q+   Q+ VE+DV KPDL+AALK+IR QYE +
Sbjct: 186 LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245

Query: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEA 328
           A+ NM  AEEW++S+F  LT++AA+N + +R AK E ++ RR L++ T ++E+ RG NE+
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305

Query: 329 LEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAA 388
           LE+Q++E E++   + ++ Q+ + +LE E ++ K EMAR+L+EYQDLLNVK+ALDIEIA 
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365

Query: 389 YRKLLEGEETRLS 401
           YRKLLEGEE R++
Sbjct: 366 YRKLLEGEENRIT 378



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 62/310 (20%), Positives = 131/310 (42%), Gaps = 52/310 (16%)

Query: 208 ELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEK 267
           EL  R  S ++++ FL++ ++   AEL  Q++  + +   DV +    A L+++R + ++
Sbjct: 75  ELNDRFASYIEKVRFLEQQNKALAAELN-QLRAKEPTKLADVYQ----AELRELRLRLDQ 129

Query: 268 LAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNE 327
           L A +         +R  V  ++ A++   VR         ++L     L +EA      
Sbjct: 130 LTANS---------ARLEVERDNLAQDLATVR---------QKLQDETNLRLEA----EN 167

Query: 328 ALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQD-LLNVKMALDIEI 386
            L    QE ++   A +  ++  I  LE E+R  +      ++E Q+ L   ++ +++++
Sbjct: 168 NLAAYRQEADEATLARLD-LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDV 226

Query: 387 AAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL-----QTSSYLMSTRSFPS 441
           A        +E R   T   ++ S     ++ + RS +  L     + +  L   +   +
Sbjct: 227 AKPDLTAALKEIR---TQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEAN 283

Query: 442 YYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEA---A 498
            Y   +Q    ++E      ++             E + +++EE    EAA  +EA    
Sbjct: 284 DYRRQLQSLTCDLESLRGTNES------------LERQMREQEERHVREAASYQEALARL 331

Query: 499 KEESEEAKEE 508
           +EE +  K+E
Sbjct: 332 EEEGQSLKDE 341


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  305 bits (780), Expect = 9e-83
 Identities = 201/518 (38%), Positives = 292/518 (56%), Gaps = 22/518 (4%)

Query: 33  YSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKA 92
           +S  R++ SS SA  S     R + ++SS   + +L N     + A++         EK 
Sbjct: 48  HSWTRTSVSSVSASPSR---FRGAGAASSTDSLDTLSNGPEGCMVAVATS-----RSEKE 99

Query: 93  QLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAED 152
           QLQ LNDRFA +I++V +LE  N+ LE E   LRQ+ +  S    LYE+E+R++R A   
Sbjct: 100 QLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLR 159

Query: 153 ATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKR 212
               +  L+ E+E L E + +++ R ++E   RE+AE       + A EA  AR +L+K+
Sbjct: 160 LGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKK 219

Query: 213 IDSLMDEISFLKKVHEEEIAELQAQIQ-----YAQISVEM-DVTKPDLSAALKDIRAQYE 266
             +L +E  +L++ H+EE+ EL  QIQ      AQ+  E  D  K D+++AL++IRAQ E
Sbjct: 220 AQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLE 279

Query: 267 KLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMN 326
             A ++   +EEWF+ R   L+E+A  NTDA+R+A++E++E RR L+A+T E+EA +   
Sbjct: 280 GHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTK 339

Query: 327 EALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEI 386
           ++LE+Q  ELED+  ADI++ Q+ I +L+ ELR TK EMA  L+EYQDLLNVKMALDIEI
Sbjct: 340 DSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEI 399

Query: 387 AAYRKLLEGEETRLSFTSVG-SITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTS 445
           AAYRKLLEGEE R+ F  +  S+  G  +   V         +    +  +         
Sbjct: 400 AAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE 459

Query: 446 HVQEEQIEVEETIE---AAKAEEAKDEPPSEGEAEE--EEKDKEEAEEEEAAEEEEAAKE 500
             +E Q+  E T E    AK EE K+E   E E  E  EE+ K    EE A+ E+EA   
Sbjct: 460 QTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519

Query: 501 ESEEAKE--EEEGGEGEEGEETKEAEEEEKKVEGAGEE 536
             EEAK   E +  E EE +   E +  EK    A EE
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 97/492 (19%), Positives = 198/492 (40%), Gaps = 37/492 (7%)

Query: 73  LSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIE-RVHELEQQNKVLEAELLVLRQKHSE 131
           L ++ ++S  +K ++++EK ++ + +++    +E +  E +   +V E E    +++  +
Sbjct: 426 LPKIPSVSTHIK-VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484

Query: 132 PSRFRALYEQEIRDLRL----AAEDATNEKQALQGEREGLEETLRNLQARYEE-----EV 182
                   E E  +       A E A+ EK+A    +E  +          EE     EV
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544

Query: 183 LSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQI-QYA 241
            S E A+    E  K   EA     E  K    +           EE  +  +A+  + A
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 242 QISVEMDVTKPDLSAALKDIRAQYEKLA-AKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300
           +  V+ +   P  + A   ++ + +  A  K+ + A+   K      +   AK+ +   A
Sbjct: 605 KSPVKEEAKSP--AEAKSPVKEEAKSPAEVKSPEKAKSPTKEE--AKSPEKAKSPEKEEA 660

Query: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360
              E ++S   +KA+    E  +   +A  K  ++ +     +  + +   + ++ E ++
Sbjct: 661 KSPEKAKSP--VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718

Query: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETR-LSFTSVGSITSGYSQS---S 416
            +   +   +E +     K  +  E  +  K    E+ + L   S  + T    ++   +
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778

Query: 417 QVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKD------EP 470
             F   A   ++           P    +   E++I  +E +++   EE K       EP
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838

Query: 471 PSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKV 530
           P + E EE+     + EE++ +++EEA K+E+ + K EE+       +E    + +E KV
Sbjct: 839 PKKAE-EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK-------KEPAVEKPKESKV 890

Query: 531 EGAGEEQAAKKK 542
           E   EE   KKK
Sbjct: 891 EAKKEEAEDKKK 902



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/422 (18%), Positives = 166/422 (39%), Gaps = 38/422 (9%)

Query: 127 QKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSRE 186
           +K   P++  A    E +    A      E ++    +  ++E     +A+   EV S E
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE-----EAKSPAEVKSPE 636

Query: 187 DAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQI---QYAQI 243
            A+    E  K  ++A     E  K  +     +    K  E+  + ++A+    + A+ 
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696

Query: 244 SVEMDVTKPDLSAA-LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAK 302
            V+ +   P+ + + +K+     EK  +   + A+   K++  V  E  AK+ +  ++ +
Sbjct: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE--AKSPEKAKSPE 754

Query: 303 DEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTK 362
                     KAKTL++++      A E+     +       S +++ +   E      K
Sbjct: 755 ----------KAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804

Query: 363 SEMARYLKEYQDLLNVKMAL-------DIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS 415
            +     KE      VK  +       ++++    K  E E+   +  +     S   ++
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA 864

Query: 416 SQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGE 475
            +          +     +  +  P+       + + + EE  +  K    + E P++ E
Sbjct: 865 PKK---------EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915

Query: 476 AEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEK-KVEGAG 534
            +E+ K KE+ E  +   ++  AKE S+ A+++E   E ++ +E K  + EEK K E   
Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975

Query: 535 EE 536
           +E
Sbjct: 976 KE 977



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 5/95 (5%)

Query: 451  QIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEE 510
            ++EV+E  +  +  E   + P + +A+E  K    AE++EAA E++  KEE  +  EE+ 
Sbjct: 913  KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP---AEKKEAAPEKKDTKEEKAKKPEEKP 969

Query: 511  GGE--GEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
              E   +E ++T   E  + K E A +  +  +KD
Sbjct: 970  KTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 32/104 (30%), Positives = 58/104 (55%), Gaps = 10/104 (9%)

Query: 449  EEQIEVEETIEAAKAE--EAKDEPPSE-GEAEEEEKDKEEAEEEEAAEEEEA------AK 499
            +E  + +E  E AK E  +AK + PS+  E +E   +K++ +EE+A + EE       AK
Sbjct: 917  KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976

Query: 500  EESEEAKEEEEGGEGEEGEETKEAEEEEKKV-EGAGEEQAAKKK 542
            E+ +   +E    + E+ E++   ++++ K  E A E++AAK K
Sbjct: 977  EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 90/458 (19%), Positives = 173/458 (37%), Gaps = 37/458 (8%)

Query: 112 EQQNKVLEA---ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLE 168
           E++ KV+E    E +++ ++  E      + E+E ++ +   E+   E+   + E EG E
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAK--EEEGKEEEGGEEEEAEGGE 498

Query: 169 ETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHE 228
           E  ++  A  EE     ++A+  + E  K   EA     E  K    +           E
Sbjct: 499 EETKSPPA--EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556

Query: 229 EEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLT 288
           E  +  +A+      S E +  K        +      K  AK+   A+   K++  V  
Sbjct: 557 EAKSPPEAK------SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 289 E--SAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNA---- 342
           E  S A+    V+      +E +   KAK+   E  +   +A   + +E +  + A    
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670

Query: 343 --DISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEG--EET 398
             +  + +   + ++ E ++ +   +   +E +     K  +  E  +  K      EE 
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730

Query: 399 RLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRS----------FPSYYTSHVQ 448
           +    +   +        +         L   S    T +          FP    S V+
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790

Query: 449 EEQIEVEETIEAAKAEEAK---DEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEA 505
           EE ++  E  ++   E+AK    E P + E +   K++E+ +E +  E  + A+EE   A
Sbjct: 791 EE-VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA 849

Query: 506 KEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
             + E  +  + EE  + E  + KVE   E    K K+
Sbjct: 850 TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 30/96 (31%), Positives = 54/96 (56%), Gaps = 6/96 (6%)

Query: 453 EVEETIEAA--KAEEAKDEPPSEGEAEEEEK---DKEEAEEEEAAEEEEAAKEESEEAKE 507
           +VEE  E A  K +E+K E   E EAE+++K    ++EA  +   +E+   KE++E AK+
Sbjct: 873 KVEEKKEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931

Query: 508 EEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
           E +  + +E  +  E +E   + +   EE+A K ++
Sbjct: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/100 (24%), Positives = 50/100 (50%)

Query: 444 TSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESE 503
           T   +E++   +E     +A + K E   E   E+ ++ K EA++EEA ++++    E E
Sbjct: 850 TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE 909

Query: 504 EAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
              + E   + +  E+T+ A++E    +     + A+KK+
Sbjct: 910 APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 121/600 (20%), Positives = 223/600 (37%), Gaps = 109/600 (18%)

Query: 17  RYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQV 76
           R  E  +V+  ++RS    A+   + Y   + +  +   +  S+  SL      L+    
Sbjct: 299 RLSEAAKVNTDAMRS----AQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQ 354

Query: 77  AAISN----------DLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLV-- 124
           A I++          +L++ + +  AQL++  D     +    E+    K+LE E     
Sbjct: 355 ADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIG 414

Query: 125 -----------LRQKHSEPSRFRALYEQEIRDLR------LAAEDATNEKQALQGEREGL 167
                      L +  S  +  +   E++I+ +       +  E+ T E Q  +   E  
Sbjct: 415 FGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474

Query: 168 EETLRNLQARYEEEVLSREDAEGRLMEARKG-ADEAALARAELEKRIDSLMDEISFLKKV 226
           E+  +  + + EEE    E+AEG   E +   A+EAA    E +  +       +  K  
Sbjct: 475 EKEAKEEEGK-EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533

Query: 227 HEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTV 286
            +EE          A+   E+   +   S A ++ ++  E   AK+ +  E   KS   V
Sbjct: 534 EKEE----------AKSPAEVKSPEKAKSPAKEEAKSPPE---AKSPEKEEA--KSPAEV 578

Query: 287 LTESAAKNTDAVRAAKDEV---SESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNAD 343
            +   AK+      AK+E    +E++   KAK+   E  +   EA  K   + E K  A+
Sbjct: 579 KSPEKAKSP-----AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA--KSPVKEEAKSPAE 631

Query: 344 ISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFT 403
           + + +   +  + E ++ +   +   +E +     K  +  E  +  K         + +
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK---------AKS 682

Query: 404 SVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETI----- 458
            V +      ++       A    +  S +      P    S V+EE    E+       
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742

Query: 459 EAAKAEEAKD---------------------------------EPPSEGEAEEEEKDKEE 485
           EA   E+AK                                  + P + E +  EK K  
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802

Query: 486 AEEEEAAEEEEAAKEESEEA--KEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
            +E+  A E+E  K+E  ++  KEEE+  E +  E  K+AEEE+       EE+   KK+
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862


>gi|4504919 keratin 8 [Homo sapiens]
          Length = 483

 Score =  243 bits (619), Expect = 4e-64
 Identities = 158/472 (33%), Positives = 258/472 (54%), Gaps = 28/472 (5%)

Query: 22  PRVHISSVRSGYSTARSAYSSYSAPVSSSL--SVRRSYSSSSGSLMPSLENLDLSQ---- 75
           PR   S   +    +R + SS+S   SS+    +   Y  +SG  M  +  + ++Q    
Sbjct: 17  PRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASG--MGGITAVTVNQSLLS 74

Query: 76  --VAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPS 133
             V  +  +++++RTQEK Q++ LN++FASFI++V  LEQQNK+LE +  +L+Q+ +  S
Sbjct: 75  PLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARS 134

Query: 134 RFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLM 193
               ++E  I +LR   E    EK  L+ E   ++  + + + +YE+E+  R + E   +
Sbjct: 135 NMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFV 194

Query: 194 EARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP- 252
             +K  DEA + + ELE R++ L DEI+FL++++EEEI ELQ+QI    + + MD ++  
Sbjct: 195 LIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSL 254

Query: 253 DLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLL 312
           D+ + + +++AQYE +A ++   AE  ++ ++  L   A K+ D +R  K E+SE  R +
Sbjct: 255 DMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNI 314

Query: 313 KAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEY 372
                EIE  +G   +LE  + + E +    I      +++LE  L+  K +MAR L+EY
Sbjct: 315 SRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREY 374

Query: 373 QDLLNVKMALDIEIAAYRKLLEGEETRL-----SFTSVGSITSGYSQSSQVFGRSAYGGL 427
           Q+L+NVK+ALDIEIA YRKLLEGEE+RL     + +     TSGY+        SAYGGL
Sbjct: 375 QELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLS----SAYGGL 430

Query: 428 QT--------SSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPP 471
            +        SS+     S     TS  +   ++  ET +     E+ D  P
Sbjct: 431 TSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLP 482


>gi|67782365 keratin 7 [Homo sapiens]
          Length = 469

 Score =  232 bits (591), Expect = 7e-61
 Identities = 139/411 (33%), Positives = 241/411 (58%), Gaps = 11/411 (2%)

Query: 23  RVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISND 82
           +V +SS R G   + S Y   ++     ++VR +Y    G+ +  +  ++ S +A +  D
Sbjct: 23  QVRLSSARPGGLGSSSLYGLGAS--RPRVAVRSAYGGPVGAGIREV-TINQSLLAPLRLD 79

Query: 83  ----LKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLR-QKHSEPSRFRA 137
               L+ +R +E  Q++ LN++FASFI++V  LEQQNK+LE +  +L+ QK ++ SR   
Sbjct: 80  ADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPD 139

Query: 138 LYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARK 197
           ++E +I  LR   E    +   L+ E   +++ + + + +YE+E+  R  AE   +  +K
Sbjct: 140 IFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKK 199

Query: 198 GADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSA 256
             D A +++ ELE ++D+L DEI+FL+ ++E E+ ELQ+QI    + + MD ++  DL  
Sbjct: 200 DVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDG 259

Query: 257 ALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKT 316
            + +++AQYE++A  +   AE W++++F  L   A K+ D +R  ++E+SE  R ++   
Sbjct: 260 IIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQ 319

Query: 317 LEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLL 376
            EI+  +     LE  + E E++    +   +    +LE  L+  K +MAR L+EYQ+L+
Sbjct: 320 AEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELM 379

Query: 377 NVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL 427
           +VK+ALDIEIA YRKLLEGEE+RL+   VG++      S+   G S+ GG+
Sbjct: 380 SVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTG--GSSSGGGI 428


>gi|119395754 keratin 5 [Homo sapiens]
          Length = 590

 Score =  230 bits (586), Expect = 3e-60
 Identities = 122/361 (33%), Positives = 216/361 (59%), Gaps = 13/361 (3%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR--FR 136
           I   ++ +RT+E+ Q++ LN++FASFI++V  LEQQNKVL+ +  +L+++ ++  R    
Sbjct: 157 IDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLE 216

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
            L+EQ I +LR   +    E+  L  E   +++ + + + +YE+E+  R  AE   +  +
Sbjct: 217 PLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLK 276

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A + + ELE ++D+LMDEI+F+K   + E++++Q  +    + + MD  +  DL 
Sbjct: 277 KDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLD 336

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
           + + +++AQYE++A ++   AE W+++++  L ++A ++ D +R  K E+SE  R+++  
Sbjct: 337 SIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRL 396

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
             EI+  +     L+  + + E +    +   ++ + +LE  L+  K +MAR L+EYQ+L
Sbjct: 397 RAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQEL 456

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSVG---------SITSGYSQSSQVFGRSAYGG 426
           +N K+ALD+EIA YRKLLEGEE RLS   VG         S++SGY   S  +G    GG
Sbjct: 457 MNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSG-YGGGLGGG 515

Query: 427 L 427
           L
Sbjct: 516 L 516


>gi|5031839 keratin 6A [Homo sapiens]
          Length = 564

 Score =  226 bits (577), Expect = 3e-59
 Identities = 121/366 (33%), Positives = 218/366 (59%), Gaps = 12/366 (3%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR--FR 136
           I   ++ +R +E+ Q++ LN++FASFI++V  LEQQNKVLE +  +L+++ ++  R    
Sbjct: 152 IDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLE 211

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
            L+EQ I +LR   +    E+  L  E  G+++ + + + +YE+E+  R  AE   +  +
Sbjct: 212 PLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLK 271

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A + + EL+ + D+L DEI+FL+ +++ E++++Q  I    + + MD  +  DL 
Sbjct: 272 KDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLD 331

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
           + + +++AQYE++A ++   AE W+++++  L  +A ++ D +R  K E++E  R+++  
Sbjct: 332 SIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRL 391

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
             EI+  +     L+  + + E +    +   ++ +  LE+ L+  K ++AR LKEYQ+L
Sbjct: 392 RSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQEL 451

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSVG---------SITSGYSQSSQVFGRSAYGG 426
           +NVK+ALD+EIA YRKLLEGEE RL+   VG         +++SGY  +S V      GG
Sbjct: 452 MNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGG 511

Query: 427 LQTSSY 432
             + SY
Sbjct: 512 GSSYSY 517


>gi|155969697 keratin 6C [Homo sapiens]
          Length = 564

 Score =  226 bits (575), Expect = 5e-59
 Identities = 120/362 (33%), Positives = 218/362 (60%), Gaps = 12/362 (3%)

Query: 83  LKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR--FRALYE 140
           ++ +R +E+ Q++ LN++FASFI++V  LEQQNKVL+ +  +L+++ ++  R     L+E
Sbjct: 156 IQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFE 215

Query: 141 QEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGAD 200
           Q I +LR   +    E+  L  E   +++ + +L+ +YE+E+  R  AE   +  +K  D
Sbjct: 216 QYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVD 275

Query: 201 EAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAALK 259
            A + + EL+ + D+L DEI+FL+ +++ E++++Q  I    + + MD  +  DL + + 
Sbjct: 276 AAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA 335

Query: 260 DIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEI 319
           +++AQYE++A ++   AE W+++++  L  +A ++ D +R  K E++E  R+++    EI
Sbjct: 336 EVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEI 395

Query: 320 EACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVK 379
           +  +    +L+  + + E +    +   ++ +  LE+ L+  K ++AR LKEYQ+L+NVK
Sbjct: 396 DHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVK 455

Query: 380 MALDIEIAAYRKLLEGEETRLSFTSVG---------SITSGYSQSSQVFGRSAYGGLQTS 430
           +ALD+EIA YRKLLEGEE RL+   VG         +I+SGY  +S V      GG  + 
Sbjct: 456 LALDVEIATYRKLLEGEECRLNGEGVGQVNVSVVQSTISSGYGGASGVGSGLGLGGGSSY 515

Query: 431 SY 432
           SY
Sbjct: 516 SY 517


>gi|119703753 keratin 6B [Homo sapiens]
          Length = 564

 Score =  224 bits (571), Expect = 2e-58
 Identities = 119/362 (32%), Positives = 218/362 (60%), Gaps = 12/362 (3%)

Query: 83  LKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR--FRALYE 140
           ++ +R +E+ Q++ LN++FASFI++V  LEQQNKVL+ +  +L+++ ++  R     L+E
Sbjct: 156 IQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFE 215

Query: 141 QEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGAD 200
           Q I +LR   ++   E+  L  E   +++ + +L+ +YE+E+  R  AE   +  +K  D
Sbjct: 216 QYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVD 275

Query: 201 EAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAALK 259
            A + + EL+ + D+L DEI+FL+ +++ E++++Q  I    + + MD  +  DL + + 
Sbjct: 276 AAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA 335

Query: 260 DIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEI 319
           +++AQYE++A ++   AE W+++++  L  +A ++ D +R  K E++E  R+++    EI
Sbjct: 336 EVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEI 395

Query: 320 EACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVK 379
           +  +     L+  + + E +    +   ++ +  LE+ L+  K ++AR LKEYQ+L+NVK
Sbjct: 396 DHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVK 455

Query: 380 MALDIEIAAYRKLLEGEETRLSFTSVG---------SITSGYSQSSQVFGRSAYGGLQTS 430
           +ALD+EIA YRKLLEGEE RL+   VG         +++SGY  +S V      GG  + 
Sbjct: 456 LALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSY 515

Query: 431 SY 432
           SY
Sbjct: 516 SY 517


>gi|153791158 keratin 75 [Homo sapiens]
          Length = 551

 Score =  223 bits (568), Expect = 3e-58
 Identities = 129/414 (31%), Positives = 229/414 (55%), Gaps = 20/414 (4%)

Query: 27  SSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMP--SLENLDLSQVAA------ 78
           SS RSG+    S     ++       V   +S  S  + P   ++ + ++Q         
Sbjct: 78  SSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQ 137

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR--FR 136
           I   ++ +R +E+ Q++ LN++FASFI++V  LEQQNKVLE +  +L+++ S   R    
Sbjct: 138 IDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLE 197

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
            L++    +LR   E  T E+  L+ E   +++ + + + RYE+E+  R  AE   +  +
Sbjct: 198 PLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALK 257

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A + + ELE ++ SL +EI+F+  V + E+++LQ Q+    + + MD  +  DL 
Sbjct: 258 KDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLD 317

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
           + + +++AQYE +A ++   AE W+++++  L  +A ++ D +R  K E+SE  R+++  
Sbjct: 318 SIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRL 377

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
             EI++ +    +L+  + + E +    +   +  +  LE  L+  K +MAR L+EYQ+L
Sbjct: 378 RAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQEL 437

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSV---------GSITSGYSQSSQVFG 420
           +N+K+ALD+EIA YRKLLEGEE RLS   V          +++SGY   S + G
Sbjct: 438 MNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGG 491


>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
          Length = 600

 Score =  221 bits (564), Expect = 1e-57
 Identities = 122/338 (36%), Positives = 203/338 (60%), Gaps = 2/338 (0%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++  EK Q++ LN++FASFI++V  LEQQNK+LE +   L+++    S    L
Sbjct: 154 IDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPL 213

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I +LR   E   +++  LQ ER  L++ L   + +YEEEV+ R +AE   +  +K 
Sbjct: 214 FESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKD 273

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A + +++LE  +D+L  EI FLK ++ EEI  LQ+ I    + V+MD ++  +L   
Sbjct: 274 VDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGI 333

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +++AQYE++A ++  +AE W+++++  +  +A ++ D +R  ++E++E  RL++    
Sbjct: 334 IAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKA 393

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           EIE  +     LE  + E E +  A +S  +  +  LE  L+  K +MAR L EYQ+L+N
Sbjct: 394 EIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMN 453

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS 415
            K+ LDIEIA YR+LLEGEE+RL    VG +    S S
Sbjct: 454 AKLGLDIEIATYRRLLEGEESRLC-EGVGPVNISVSSS 490


>gi|153791670 keratin 76 [Homo sapiens]
          Length = 638

 Score =  214 bits (544), Expect = 2e-55
 Identities = 123/382 (32%), Positives = 216/382 (56%), Gaps = 15/382 (3%)

Query: 62  GSLMPSLENLDLSQVAAISND--LKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLE 119
           G +   + N  L Q   +  D  +  ++ QE+ Q++ LN++FASFI++V  LEQQNKVLE
Sbjct: 153 GGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLE 212

Query: 120 AELLVLRQKH--SEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQAR 177
            +  +L+Q+   S PS     +E  I  L    +    E+  L+GE + +++ + + + +
Sbjct: 213 TKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKK 272

Query: 178 YEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQ 237
           YE+E+  R  AE   +  +K  D A + + EL+ ++DSL DE+SFL+ ++E E++++Q+ 
Sbjct: 273 YEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSH 332

Query: 238 IQYAQISVEMDVTKP-DLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTD 296
                + + MD  +  DL + + ++RAQYE++A ++   AE  ++++   L  +A ++ D
Sbjct: 333 ASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGD 392

Query: 297 AVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLEN 356
            +R  K E+ E  R+++    EIE  +  N  L+  + E E +    +      +  L+ 
Sbjct: 393 DLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQT 452

Query: 357 ELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLS--------FTSVGSI 408
            L+  K ++AR L++YQ+L+NVK+ALD+EIA YRKLLEGEE R+S         + V ++
Sbjct: 453 ALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNV 512

Query: 409 TSGYSQSSQVFGRSAYGGLQTS 430
           TS  +  S    R  +GG+  S
Sbjct: 513 TS--TSGSSGSSRGVFGGVSGS 532


>gi|4504935 keratin 85 [Homo sapiens]
          Length = 507

 Score =  214 bits (544), Expect = 2e-55
 Identities = 138/416 (33%), Positives = 225/416 (54%), Gaps = 24/416 (5%)

Query: 22  PRVHISSVRSGYSTARSAYSSY-----SAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQV 76
           PR+ +   R+G       Y S      S P  +++SV  S           L  L+L   
Sbjct: 64  PRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESL----------LTPLNLE-- 111

Query: 77  AAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFR 136
             I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +    + +    S   
Sbjct: 112 --IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLE 169

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
            L+   I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +
Sbjct: 170 PLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLK 229

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A L +++LE  +++L++E SFL++++EEEI  LQA I    + V+MD ++  ++ 
Sbjct: 230 KDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMD 289

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
             + +I+AQY+ +A+++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  
Sbjct: 290 CIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRL 349

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
           T EIE  +     LE  + E E +  A +S  +  + +LE  L+  K +MA  LKEYQ++
Sbjct: 350 TAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEV 409

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSS 431
           +N K+ LDIEIA YR+LLEGEE RL    VGS+    S S    G  + GGL  S+
Sbjct: 410 MNSKLGLDIEIATYRRLLEGEEHRLC-EGVGSVNVCVSSSR---GGVSCGGLSYST 461


>gi|28173564 keratin 73 [Homo sapiens]
          Length = 540

 Score =  213 bits (542), Expect = 4e-55
 Identities = 132/400 (33%), Positives = 227/400 (56%), Gaps = 23/400 (5%)

Query: 32  GYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSL--------ENLDLSQVAAISNDL 83
           GY   R   S ++  +  S+++        GS+ PSL          ++ S +A ++ +L
Sbjct: 70  GYGFGRGRASGFAGSMFGSVAL--------GSVCPSLCPPGGIHQVTINKSLLAPLNVEL 121

Query: 84  ----KSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQK--HSEPSRFRA 137
               + +R QE+ Q++ LN++FASFI++V  LEQQN+VLE +  +L+Q   ++  +    
Sbjct: 122 DPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEP 181

Query: 138 LYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARK 197
           + E  I +LR   E  + ++  L  E   + E + + + RYEEE+  R  AE   +  +K
Sbjct: 182 ILEGYISNLRKQLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKK 241

Query: 198 GADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSA 256
             D A  ++ EL+ ++D+L  EI F K ++E E A++Q+ I    I + MD  +  DL +
Sbjct: 242 DVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDS 301

Query: 257 ALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKT 316
            + ++RAQYE++A K+   AE  ++++F  L  +A ++ D ++  K+E+SE  RL++   
Sbjct: 302 IIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLR 361

Query: 317 LEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLL 376
            EIE+ +     LE  + + E + +  +   +  +++LE  L+  K E+AR L+EYQ+LL
Sbjct: 362 SEIESVKKQCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQELL 421

Query: 377 NVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSS 416
           +VK++LDIEIA YRKLLEGEE R+S     S++     SS
Sbjct: 422 SVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSISVINSS 461


>gi|109148552 keratin 3 [Homo sapiens]
          Length = 628

 Score =  212 bits (540), Expect = 6e-55
 Identities = 116/354 (32%), Positives = 205/354 (57%), Gaps = 6/354 (1%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKH----SEPSR 134
           I   +  ++ QE+ Q++ LN++FASFI++V  LEQQNKVLE +  +L+Q+     S  + 
Sbjct: 187 IDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNN 246

Query: 135 FRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLME 194
              L+E  I  LR   ++   E+  L  E + +E+ + + + +YE+E+  R  AE   + 
Sbjct: 247 LEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVT 306

Query: 195 ARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-D 253
            +K  D A + + EL+ ++D+L+DEI FL+ +++ E++++Q+ I    + + MD  +  D
Sbjct: 307 LKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLD 366

Query: 254 LSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLK 313
           L + + ++RAQYE +A ++   AE  ++++   L  +A ++ D +R  K E+ E  R+++
Sbjct: 367 LDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQ 426

Query: 314 AKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQ 373
               EIE  +  N  L+  + E E      +      + +L+  L+  K ++AR L++YQ
Sbjct: 427 RLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQ 486

Query: 374 DLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSIT-SGYSQSSQVFGRSAYGG 426
           +L+NVK+ALD+EIA YRKLLEGEE R+S     +++ S  S S+       YGG
Sbjct: 487 ELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGG 540


>gi|109255249 keratin 4 [Homo sapiens]
          Length = 594

 Score =  212 bits (539), Expect = 8e-55
 Identities = 123/352 (34%), Positives = 211/352 (59%), Gaps = 8/352 (2%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPS--RFR 136
           I  +++ +RT+E+ Q++ LN++FASFI++V  LEQQNKVLE +  +L+Q+ +  S     
Sbjct: 200 IDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLE 259

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
            L+E  +  LR   +   N+K  LQ E + +++++ + + +YEEE+  R  AE   +  +
Sbjct: 260 PLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLK 319

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A L + ELE ++DSL DEI+FLK +++ E++++Q  +    + + MD  +  DL 
Sbjct: 320 KDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLD 379

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
           + + ++RAQYE++A ++   AE  ++++   L  S  ++ D ++  K E++E  R+++  
Sbjct: 380 SIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRL 439

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
             EIE  +   + L+  + + E +    +        +LE  L+  K E+AR L+EYQ+L
Sbjct: 440 RAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQEL 499

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL 427
           ++VK+ALDIEIA YRKLLEGEE R+S    G   S  S  S V G ++ GG+
Sbjct: 500 MSVKLALDIEIATYRKLLEGEEYRMS----GECQSAVS-ISVVSGSTSTGGI 546


>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
           sapiens]
          Length = 486

 Score =  211 bits (537), Expect = 1e-54
 Identities = 125/368 (33%), Positives = 211/368 (57%), Gaps = 9/368 (2%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 95  IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 154

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 155 FEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKD 214

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 215 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCI 274

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +  ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 275 IAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 334

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 335 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 394

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL--QTSSYLMS 435
            K+ LDIEIA YR+LLEGEE RL    VGS+    S S    G    G L   T++ ++S
Sbjct: 395 SKLGLDIEIATYRRLLEGEEQRLC-EGVGSVNVCVSSSR---GGVVCGDLCASTTAPVVS 450

Query: 436 TR--SFPS 441
           TR  S PS
Sbjct: 451 TRVSSVPS 458


>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
           sapiens]
          Length = 486

 Score =  211 bits (537), Expect = 1e-54
 Identities = 125/368 (33%), Positives = 211/368 (57%), Gaps = 9/368 (2%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 95  IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 154

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 155 FEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKD 214

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 215 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCI 274

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +  ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 275 IAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 334

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 335 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 394

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL--QTSSYLMS 435
            K+ LDIEIA YR+LLEGEE RL    VGS+    S S    G    G L   T++ ++S
Sbjct: 395 SKLGLDIEIATYRRLLEGEEQRLC-EGVGSVNVCVSSSR---GGVVCGDLCASTTAPVVS 450

Query: 436 TR--SFPS 441
           TR  S PS
Sbjct: 451 TRVSSVPS 458


>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
           sapiens]
          Length = 486

 Score =  211 bits (537), Expect = 1e-54
 Identities = 125/368 (33%), Positives = 211/368 (57%), Gaps = 9/368 (2%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 95  IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 154

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 155 FEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKD 214

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 215 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCI 274

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +  ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 275 IAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 334

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 335 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 394

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL--QTSSYLMS 435
            K+ LDIEIA YR+LLEGEE RL    VGS+    S S    G    G L   T++ ++S
Sbjct: 395 SKLGLDIEIATYRRLLEGEEQRLC-EGVGSVNVCVSSSR---GGVVCGDLCASTTAPVVS 450

Query: 436 TR--SFPS 441
           TR  S PS
Sbjct: 451 TRVSSVPS 458


>gi|14318422 keratin 86 [Homo sapiens]
          Length = 486

 Score =  211 bits (537), Expect = 1e-54
 Identities = 125/368 (33%), Positives = 211/368 (57%), Gaps = 9/368 (2%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 95  IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 154

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 155 FEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKD 214

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 215 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCI 274

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +  ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 275 IAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 334

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 335 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 394

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGL--QTSSYLMS 435
            K+ LDIEIA YR+LLEGEE RL    VGS+    S S    G    G L   T++ ++S
Sbjct: 395 SKLGLDIEIATYRRLLEGEEQRLC-EGVGSVNVCVSSSR---GGVVCGDLCASTTAPVVS 450

Query: 436 TR--SFPS 441
           TR  S PS
Sbjct: 451 TRVSSVPS 458


>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
          Length = 505

 Score =  208 bits (530), Expect = 9e-54
 Identities = 113/338 (33%), Positives = 197/338 (58%), Gaps = 2/338 (0%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 95  IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 154

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +E  I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 155 FEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKD 214

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 215 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCI 274

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +  ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 275 IAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 334

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 335 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 394

Query: 378 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS 415
            K+ LDIEIA YR+LLEGEE RL    +G++    S S
Sbjct: 395 SKLGLDIEIATYRRLLEGEEQRLC-EGIGAVNVCVSSS 431


>gi|169790841 keratin 83 [Homo sapiens]
          Length = 493

 Score =  207 bits (527), Expect = 2e-53
 Identities = 110/323 (34%), Positives = 191/323 (59%), Gaps = 1/323 (0%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
           I  + + ++ +EK Q++ LN RFA+FI++V  LEQQNK+LE +L   + +    S    L
Sbjct: 100 IDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPL 159

Query: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
           +   I  LR  AE    +   L  E   ++E L   + +YEEEV  R  AE   +  +K 
Sbjct: 160 FAGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKD 219

Query: 199 ADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAA 257
            D A L +++LE  +++L+ EI FL++++EEEI  LQ+ I    + V++D ++  ++   
Sbjct: 220 VDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCI 279

Query: 258 LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
           + +I+AQY+ +A ++   AE W++S+   +  +  ++ + +R  K+E++E  R+++  T 
Sbjct: 280 VAEIKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTA 339

Query: 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLN 377
           E+E  +  N  LE  + + E +  A +S  +  + +LE  L+  K +MA  ++EYQ+++N
Sbjct: 340 EVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMN 399

Query: 378 VKMALDIEIAAYRKLLEGEETRL 400
            K+ LDIEIA YR+LLEGEE RL
Sbjct: 400 SKLGLDIEIATYRRLLEGEEQRL 422


>gi|119395750 keratin 1 [Homo sapiens]
          Length = 644

 Score =  207 bits (526), Expect = 3e-53
 Identities = 107/352 (30%), Positives = 212/352 (60%), Gaps = 4/352 (1%)

Query: 79  ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQ--KHSEPSRFR 136
           I  +++ ++++E+ Q++ LN++FASFI++V  LEQQN+VL+ +  +L+Q    +      
Sbjct: 169 IDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLE 228

Query: 137 ALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
             +E  I +LR   +   +++  L  E + +++ + + + +YE+E+  R +AE   +  +
Sbjct: 229 PYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIK 288

Query: 197 KGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLS 255
           K  D A + + +L+ ++D+L  EI FL  +++ E++++Q QI    + + MD  +  DL 
Sbjct: 289 KDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLD 348

Query: 256 AALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAK 315
           + + +++AQYE +A K+   AE  ++S++  L  +A ++ D+VR +K E+SE  R+++  
Sbjct: 349 SIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRL 408

Query: 316 TLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDL 375
             EI+  +     L++ + + E +    +   ++ +N LE+ L+  K ++AR L++YQ+L
Sbjct: 409 RSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQEL 468

Query: 376 LNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS-SQVFGRSAYGG 426
           +N K+ALD+EIA YR LLEGEE+R+S     +++   S S + + G  + GG
Sbjct: 469 MNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGG 520


>gi|27477127 keratin 82 [Homo sapiens]
          Length = 513

 Score =  203 bits (517), Expect = 3e-52
 Identities = 119/352 (33%), Positives = 197/352 (55%), Gaps = 2/352 (0%)

Query: 69  ENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQK 128
           E+L +     I   ++ ++  EK Q++ LN+RFASFI +V  LEQ+NK+LE +   ++Q+
Sbjct: 99  ESLLVPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQ 158

Query: 129 HSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDA 188
               +    ++E  I  LR   +  + ++  L+ E   L+  L   + +YEEE+  R   
Sbjct: 159 RCCQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCV 218

Query: 189 EGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMD 248
           E   +  +K  D A L +A+LE   ++L+ EI FLK ++EEEI  LQ+QI    + V+MD
Sbjct: 219 ENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMD 278

Query: 249 VTKP-DLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSE 307
            ++  D+   + +I+AQY+ +A+++   AE W++ R+  L  +A  + D +R  K+E+ E
Sbjct: 279 NSRELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILE 338

Query: 308 SRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMAR 367
             +L++    E E  +     LE  + E E +  A ++  +  +  LE  L+  K +MA 
Sbjct: 339 MNKLIQRLQQETENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMAC 398

Query: 368 YLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVF 419
            LKEYQ+++N K+ LDIEIA YR+LLEGEE RL    +G +    S S   F
Sbjct: 399 LLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLC-EGIGPVNISVSSSKGAF 449


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.303    0.121    0.303 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,827,531
Number of Sequences: 37866
Number of extensions: 873772
Number of successful extensions: 59573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1487
Number of HSP's successfully gapped in prelim test: 1081
Number of HSP's that attempted gapping in prelim test: 10403
Number of HSP's gapped (non-prelim): 21440
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.