Guide to the Human Genome
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Search of human proteins with 105553088

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|105553088 t-complex 10 [Homo sapiens]
         (326 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|105553088 t-complex 10 [Homo sapiens]                              654   0.0  
gi|223468602 t-complex 10-like 2 [Homo sapiens]                       629   0.0  
gi|21389535 T-complex 10A-2 [Homo sapiens]                            278   5e-75
gi|130980075 centromere protein J [Homo sapiens]                       56   5e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...    44   3e-04
gi|171906567 peripheral benzodiazepine receptor-associated prote...    44   3e-04
gi|171906559 peripheral benzodiazepine receptor-associated prote...    44   3e-04
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...    43   4e-04
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    42   6e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        42   6e-04
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         42   7e-04
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        42   0.001
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...    41   0.001
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...    40   0.004
gi|23308697 signal recognition particle receptor [Homo sapiens]        40   0.004
gi|153085395 histone deacetylase 4 [Homo sapiens]                      39   0.005
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.005
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.005
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    39   0.005
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora...    39   0.006
gi|70980547 FYVE-finger-containing Rab5 effector protein rabenos...    39   0.006
gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo ...    39   0.008
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]     39   0.008
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    39   0.008
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    39   0.008
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    39   0.008
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    39   0.008
gi|29893555 angiopoietin-like 6 [Homo sapiens]                         39   0.008
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...    38   0.014
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]           38   0.014

>gi|105553088 t-complex 10 [Homo sapiens]
          Length = 326

 Score =  654 bits (1688), Expect = 0.0
 Identities = 326/326 (100%), Positives = 326/326 (100%)

Query: 1   MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR 60
           MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR
Sbjct: 1   MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR 60

Query: 61  ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKS 120
           ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKS
Sbjct: 61  ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKS 120

Query: 121 QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180
           QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP
Sbjct: 121 QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180

Query: 181 GAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSE 240
           GAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSE
Sbjct: 181 GAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSE 240

Query: 241 GGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKAD 300
           GGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKAD
Sbjct: 241 GGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKAD 300

Query: 301 DCRRSGFPSEFPGALHAAPSRQDMGP 326
           DCRRSGFPSEFPGALHAAPSRQDMGP
Sbjct: 301 DCRRSGFPSEFPGALHAAPSRQDMGP 326


>gi|223468602 t-complex 10-like 2 [Homo sapiens]
          Length = 353

 Score =  629 bits (1623), Expect = 0.0
 Identities = 316/326 (96%), Positives = 319/326 (97%)

Query: 1   MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR 60
           MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR
Sbjct: 28  MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR 87

Query: 61  ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKS 120
           ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKIS LSADE+TTPKYAGRKS
Sbjct: 88  ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISPLSADEETTPKYAGRKS 147

Query: 121 QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180
           QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP
Sbjct: 148 QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 207

Query: 181 GAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSE 240
           GAERR VSEDGKIMHPSSRS QNSGGRKSPVQASQA TLQEQTAAA  ADRSSSVLGSSE
Sbjct: 208 GAERREVSEDGKIMHPSSRSLQNSGGRKSPVQASQAATLQEQTAAAGVADRSSSVLGSSE 267

Query: 241 GGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKAD 300
           GGFLSRVQA+EFASS+PDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHP GKAD
Sbjct: 268 GGFLSRVQAEEFASSSPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPNGKAD 327

Query: 301 DCRRSGFPSEFPGALHAAPSRQDMGP 326
           DCRRSGFPSEFPGALHAAPSRQDMGP
Sbjct: 328 DCRRSGFPSEFPGALHAAPSRQDMGP 353


>gi|21389535 T-complex 10A-2 [Homo sapiens]
          Length = 215

 Score =  278 bits (711), Expect = 5e-75
 Identities = 141/186 (75%), Positives = 157/186 (84%)

Query: 1   MEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNR 60
           MEKT  AAEV  ED N GEMP LQQQI  LHQELGRQ+SLWAD+H KL+SH+DALR+QN 
Sbjct: 28  MEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNM 87

Query: 61  ELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKS 120
           ELRE+LR LQ Q+W+A KK AASPHAG+ESHTLALEPAFGKIS LSADE+T PKYAG K+
Sbjct: 88  ELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKN 147

Query: 121 QSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180
           QSATLLGQR SSN+ APPKPMSLK ERI+S KTPPQE+R+K+   RRQDR   PTGRPTP
Sbjct: 148 QSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTP 207

Query: 181 GAERRG 186
            AERRG
Sbjct: 208 CAERRG 213


>gi|130980075 centromere protein J [Homo sapiens]
          Length = 1338

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 48/201 (23%), Positives = 91/201 (45%), Gaps = 22/201 (10%)

Query: 2    EKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRE 61
            EK   AA    +     E+ +L+QQI  L ++L R+++ W+  H +L+S +  L ++N +
Sbjct: 978  EKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037

Query: 62   LREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQ 121
            LREE++ ++R + +A K+              A+E +  ++       +T+ ++   +  
Sbjct: 1038 LREEIKVMERFRLDAWKRAE------------AIESSL-EVEKKDKLANTSVRFQNSQIS 1084

Query: 122  SATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSP-APTGRPTP 180
            S T + +++  N+L    PM     R  S   PP++            R P  P   P P
Sbjct: 1085 SGTQV-EKYKKNYL----PMQGNPPR-RSKSAPPRDLGNLDKGQAASPREPLEPLNFPDP 1138

Query: 181  GAERRGVSED--GKIMHPSSR 199
              +     +D  G+I HP  +
Sbjct: 1139 EYKEEEEDQDIQGEISHPDGK 1159


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 73/326 (22%), Positives = 135/326 (41%), Gaps = 45/326 (13%)

Query: 24  QQQITSLHQELGRQQSLWADIHRKL---QSHMDALRKQNRELREELRGLQRQQWEAGKKP 80
           Q+Q+  L Q+L  +Q+L  +  RK    Q   + L++Q ++ R+ L  LQ Q+ E     
Sbjct: 455 QRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514

Query: 81  AASPHAGRESHTLALEPAFGK-ISHLSADEDTTPKYAGRKS------------------Q 121
               +  +E  + + +PA+ K I HL A +   P     +S                   
Sbjct: 515 KKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 574

Query: 122 SATLLGQRWSSNHLAPPKPMSLKTERIN-SGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180
           S  +   R +S+  +   P+  + E+ + S     +ED     P R    SPA   + +P
Sbjct: 575 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 634

Query: 181 G-----AERRGVSEDGKIMHPSSRSPQ---NSGGRKSPVQASQATTLQEQTAAARGADRS 232
           G       R G S+  +  +P  R  +    S  +++   +S +++      +++G  + 
Sbjct: 635 GNGSALGPRLG-SQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 693

Query: 233 SSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQ--------AMDTKMK 284
            S  GSSE    +RV+A+  +  +P     +   V P  S +I +        A+  +++
Sbjct: 694 GSQAGSSE---RTRVRANSKSEGSP-VLPHEPAKVKPEESRDITRPSRPADLTALAKELR 749

Query: 285 KEEVQEEKRHPKGKADDCRRSGFPSE 310
           +  ++E  R P  K  D   S   SE
Sbjct: 750 ELRIEETNR-PMKKVTDYSSSSEESE 774


>gi|171906567 peripheral benzodiazepine receptor-associated protein
           1 isoform b [Homo sapiens]
          Length = 1797

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 71/322 (22%), Positives = 118/322 (36%), Gaps = 49/322 (15%)

Query: 14  DSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRELREELRGLQRQQ 73
           DS   +   LQ ++ SL Q L   + + A   ++L+   +  R   RE +EE+R LQ+ Q
Sbjct: 358 DSALRKSQGLQSKLESLEQVLKHMREV-AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQ 416

Query: 74  WEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSN 133
            EA ++           H  A++     +  + A      +    +++  +LL Q   + 
Sbjct: 417 AEAQRE-----------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAF 465

Query: 134 HLAPPKPMSLKTERINSGK-----------TPPQEDREKSP---------PGRRQDRSPA 173
            L P  P+ L T  ++ G            + PQ  R   P         PGR   +S  
Sbjct: 466 RLHPG-PLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSE 524

Query: 174 PTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPV----QASQATTLQEQTAAARGA 229
           P      G  RR   +   + + S     ++  +  P      AS+   L+  + +   A
Sbjct: 525 PAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPA 584

Query: 230 DRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQ 289
               S  G+    FL+R   + F    P+      LP+     + I   MD         
Sbjct: 585 APEGSRGGARIQVFLARYSYNPF--EGPNENPEAELPLTAGEYIYIYGNMD--------- 633

Query: 290 EEKRHPKGKADDCRRSGFPSEF 311
            E    +G+  D RR   PS F
Sbjct: 634 -EDGFFEGELMDGRRGLVPSNF 654


>gi|171906559 peripheral benzodiazepine receptor-associated protein
           1 isoform a [Homo sapiens]
          Length = 1857

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 71/322 (22%), Positives = 118/322 (36%), Gaps = 49/322 (15%)

Query: 14  DSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRELREELRGLQRQQ 73
           DS   +   LQ ++ SL Q L   + + A   ++L+   +  R   RE +EE+R LQ+ Q
Sbjct: 418 DSALRKSQGLQSKLESLEQVLKHMREV-AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQ 476

Query: 74  WEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSN 133
            EA ++           H  A++     +  + A      +    +++  +LL Q   + 
Sbjct: 477 AEAQRE-----------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAF 525

Query: 134 HLAPPKPMSLKTERINSGK-----------TPPQEDREKSP---------PGRRQDRSPA 173
            L P  P+ L T  ++ G            + PQ  R   P         PGR   +S  
Sbjct: 526 RLHPG-PLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSE 584

Query: 174 PTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPV----QASQATTLQEQTAAARGA 229
           P      G  RR   +   + + S     ++  +  P      AS+   L+  + +   A
Sbjct: 585 PAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPA 644

Query: 230 DRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQ 289
               S  G+    FL+R   + F    P+      LP+     + I   MD         
Sbjct: 645 APEGSRGGARIQVFLARYSYNPF--EGPNENPEAELPLTAGEYIYIYGNMD--------- 693

Query: 290 EEKRHPKGKADDCRRSGFPSEF 311
            E    +G+  D RR   PS F
Sbjct: 694 -EDGFFEGELMDGRRGLVPSNF 714


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 66/299 (22%), Positives = 124/299 (41%), Gaps = 36/299 (12%)

Query: 24  QQQITSLHQELGRQQSLWADIHRKL---QSHMDALRKQNRELREELRGLQRQQWEAGKKP 80
           Q+Q+  L Q+L  +Q+L  +  RK    Q   + L++Q ++ R+ L  LQ Q+ E     
Sbjct: 455 QRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514

Query: 81  AASPHAGRESHTLALEPAFGK-ISHLSADEDTTPKYAGRKS------------------Q 121
               +  +E  + + +PA+ K I HL A +   P     +S                   
Sbjct: 515 KKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 574

Query: 122 SATLLGQRWSSNHLAPPKPMSLKTERIN-SGKTPPQEDREKSPPGRRQDRSPAPTGRPTP 180
           S  +   R +S+  +   P+  + E+ + S     +ED     P R    SPA   + +P
Sbjct: 575 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 634

Query: 181 G-----AERRGVSEDGKIMHPSSRSPQ---NSGGRKSPVQASQATTLQEQTAAARGADRS 232
           G       R G S+  +  +P  R  +    S  +++   +S +++      +++G  + 
Sbjct: 635 GNGSALGPRLG-SQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 693

Query: 233 SSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEE 291
            S  GSSE    +RV+A+  +  +P     +   V P  S +I +       K+ + E+
Sbjct: 694 GSQAGSSE---RTRVRANSKSEGSP-VLPHEPAKVKPEESRDITRPSRPASYKKAIDED 748


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 65/303 (21%), Positives = 111/303 (36%), Gaps = 45/303 (14%)

Query: 4   TPAAAE-----VPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQ 58
           TP+ AE      P +DS         Q ++S+ Q   +Q    +  H   Q    ++ + 
Sbjct: 376 TPSTAEPSKFPFPTKDS---------QHVSSVTQNQ-KQYDTSSKTHSNSQQGTSSMLED 425

Query: 59  NRELREELRGLQRQQWEAGKKPAASPHAGRE-SHTLALEPAFGKISHLSADEDTTPKYAG 117
           + +L +       Q  E     +A P A +     +A   +    S  ++D D++     
Sbjct: 426 DLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSES 485

Query: 118 RKSQSATLLGQRWSSNHLAPPKPMSLKTE------RINSGKTPPQEDREKSPPGRRQDR- 170
             S S +   +   +    P  P + K +      +++    PP+  R   PP R  +  
Sbjct: 486 ESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESK 545

Query: 171 --SPAPTGR-------PTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQE 221
             S + T +       P P +  +      +  HP  RS Q S  ++ P Q     T Q 
Sbjct: 546 GSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQP 605

Query: 222 Q---TAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPD---------SAERQNLPVNP 269
           +    A+AR   R +S+ G  E G L     D+ +   P          +A  +  P  P
Sbjct: 606 KKPVKASARAGSR-TSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVP 664

Query: 270 PSS 272
           PSS
Sbjct: 665 PSS 667


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 52/189 (27%), Positives = 73/189 (38%), Gaps = 19/189 (10%)

Query: 138  PKPMSLKTERINSGKTPPQEDREKSP-PGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHP 196
            P P S   +  +    PP +D+ +SP P    D+S     + TP A  + +S        
Sbjct: 2425 PSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTT 2484

Query: 197  SSRSPQNS-------GGRKSPVQASQATTLQEQTAAA---------RGADRSSSVLGSSE 240
            SS    N        G   S V    A+T  +Q +A          R +  SSS   SS 
Sbjct: 2485 SSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSS 2544

Query: 241  GGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKAD 300
                S   +    SS+ DS E  +LPV P  +L+   +  T   KE V+E +      A 
Sbjct: 2545 SSSSSSSSSSSSGSSSSDS-EGSSLPVQPEVALKRVPS-PTPAPKEAVREGRPPEPTPAK 2602

Query: 301  DCRRSGFPS 309
              RRS   S
Sbjct: 2603 RKRRSSSSS 2611



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 60/271 (22%), Positives = 104/271 (38%), Gaps = 36/271 (13%)

Query: 12   REDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRELREELRG--L 69
            R+ S + +  S ++Q +     + R++   +  H +  +  ++ R  +R  R   R    
Sbjct: 1788 RDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPT 1847

Query: 70   QRQQWEAGKKPA--------ASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQ 121
             R++  +   PA        ASP   R S +         IS   +   T+P  + R+S+
Sbjct: 1848 SRKRSRSRTSPAPWKRSRSRASPATHRRSRSRT-----PLISRRRSRSRTSP-VSRRRSR 1901

Query: 122  SATLLGQRWSSNHLAPPKPMSLKTERINSGKTPP---QEDREKSPPGRRQDRSPAPTGRP 178
            S T + +R S +  +P       + R +  +TPP   +  R ++P  RR+ RS  P    
Sbjct: 1902 SRTSVTRRRSRSRASPV------SRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTP---- 1951

Query: 179  TPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGS 238
             P   RR  S    +    SRS      R SP+   ++ +        R   R+S V   
Sbjct: 1952 -PVTRRRSRSRTPPVTRRRSRS------RTSPITRRRSRSRTSPVTRRRSRSRTSPVTRR 2004

Query: 239  SEGGFLSRVQADEFASSAPDSAERQNLPVNP 269
                  S V      S  P +  R++    P
Sbjct: 2005 RSRSRTSPVTRRRSRSRTPPAIRRRSRSRTP 2035



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 69/282 (24%), Positives = 108/282 (38%), Gaps = 37/282 (13%)

Query: 47  KLQSHMDALRKQNRELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLS 106
           K + H     K  R+ +++ R   R    A K   A  H    + + +        S  +
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRA--HRSTSADSASSSDTSRSRSRSA 282

Query: 107 ADEDTTPKYAGRKSQSATLLGQRWSSNHLAP-PKPMSLKTERINSGKTP------PQEDR 159
           A +  T   AGR    A+  G+R   +  AP  +P +  T+R +S +T       P ED+
Sbjct: 283 AAKTHTTALAGRSPSPAS--GRRGEGD--APFSEPGTTSTQRPSSPETATKQPSSPYEDK 338

Query: 160 EK----------SPPGRRQDRSPAPTGRPTP-GAERRGVSEDGKIMHPSSRSPQNSGGRK 208
           +K          SP   R    P P   PTP  AER G S       P S+ P N     
Sbjct: 339 DKDKKEKSATRPSPSPERSSTGPEPPA-PTPLLAERHGGSPQPLATTPLSQEPVNPPSEA 397

Query: 209 SPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVN 268
           SP +        E+   +  ++ S     S +   +SR      ASS+P+S +       
Sbjct: 398 SPTRDRSPPKSPEKLPQSSSSESSPP---SPQPTKVSR-----HASSSPESPKPAPA--- 446

Query: 269 PPSSLEIAQAMDTKMKKE-EVQEEKRHPKGKADDCRRSGFPS 309
           P S  EI+ +  +K +     + +K H    +    RS  P+
Sbjct: 447 PGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPA 488



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 72/339 (21%), Positives = 110/339 (32%), Gaps = 71/339 (20%)

Query: 2    EKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRE 61
            ++  + +E   +       P  Q+  +   QEL  + S       +  S  D+  K    
Sbjct: 1513 QRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTP 1572

Query: 62   LREELRGLQRQQWEAGKKPAASPHAGRESHTLALE--PAFGKISHLSADEDTTPKYAG-- 117
            LR+  R       E   K   SP   R   +  ++  P     +   +D    PK     
Sbjct: 1573 LRQRSRSGSSP--EVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPR 1630

Query: 118  ---RKSQSATLLGQRW------SSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQ 168
               R+S+S +    R       SS   +P  P   +T R  S  +P  + + ++PP RR 
Sbjct: 1631 ALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRS 1690

Query: 169  DRSPAPTGRP-------------------TPGAERRGVSEDGKIMHPSSRSPQNSGGRKS 209
             RS     R                    TP   RR  S         SRS +      S
Sbjct: 1691 SRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASS 1750

Query: 210  P------------------VQASQATTLQEQTAAARGADRSSSVLGSSE----------- 240
            P                  +Q S++ + +E+T   R  DRS S   +S            
Sbjct: 1751 PRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRV 1810

Query: 241  -------GGFLSRVQADEFASSAPDSAERQNLPVNPPSS 272
                    G+ SR  A +  SS   S  R+     PP+S
Sbjct: 1811 TRRRRGGSGYHSRSPARQ-ESSRTSSRRRRGRSRTPPTS 1848



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 42/162 (25%), Positives = 63/162 (38%), Gaps = 13/162 (8%)

Query: 79  KPAASPHAGRESHTLALEPAFGKISHLSADED-----TTPKYAGRKSQSATLLGQRWSSN 133
           KPA +P + RE   ++  P     SH  A  D     T  +  GR    AT   +R  S 
Sbjct: 442 KPAPAPGSHRE---ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPAT--AKRGRSR 496

Query: 134 HLAPPKP--MSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTG-RPTPGAERRGVSED 190
              P K      ++ +    ++  +  R +SP  R + RSP   G   +   +RRG S  
Sbjct: 497 SRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRS 556

Query: 191 GKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRS 232
            +     SRSP   G  +S   A +  +     A  R   R+
Sbjct: 557 ARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRT 598



 Score = 37.0 bits (84), Expect = 0.024
 Identities = 44/194 (22%), Positives = 75/194 (38%), Gaps = 17/194 (8%)

Query: 70  QRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQR 129
           QR+  EA K+PA  P    + ++L  E +  +       +    K  GR+S+S++   +R
Sbjct: 154 QRRAREA-KQPAPEPP---KPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRER 209

Query: 130 WSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSE 189
             S+     +  S   +R +   TP  + + K    +++ RS + T  P      R  S 
Sbjct: 210 KKSSKKKKHRSESESKKRKHRSPTPKSKRKSKD---KKRKRSRSTTPAPKSRRAHRSTSA 266

Query: 190 DGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQA 249
           D      +SRS   S   K+   A           A R    +S   G  +  F      
Sbjct: 267 DSASSSDTSRSRSRSAAAKTHTTA----------LAGRSPSPASGRRGEGDAPFSEPGTT 316

Query: 250 DEFASSAPDSAERQ 263
                S+P++A +Q
Sbjct: 317 STQRPSSPETATKQ 330



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 33/157 (21%)

Query: 77   GKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLA 136
            G+ P  +P   +   + +   +    S  S+   ++   +   S S++      SS   A
Sbjct: 2593 GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPA 2652

Query: 137  PPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSP---------------------APT 175
             P P +L          P     +K PPG R+ RSP                      P+
Sbjct: 2653 KPGPQAL----------PKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPS 2702

Query: 176  GRPTPGAERRGVSEDG--KIMHPSSRSPQNSGGRKSP 210
             +P+P  ++   SE G  +     SRSP +   R++P
Sbjct: 2703 PQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETP 2739



 Score = 33.5 bits (75), Expect = 0.26
 Identities = 28/130 (21%), Positives = 49/130 (37%), Gaps = 1/130 (0%)

Query: 101 KISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDRE 160
           K S +S+    +      K++S   L +  S +   P +       R  SG + P+  + 
Sbjct: 750 KKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKA-KS 808

Query: 161 KSPPGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQ 220
           ++PP R +  S  P  + +    R+  S         S +P   G   SP    Q+ T Q
Sbjct: 809 RTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQ 868

Query: 221 EQTAAARGAD 230
            ++      D
Sbjct: 869 RRSCFESSPD 878



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 42/195 (21%), Positives = 71/195 (36%), Gaps = 36/195 (18%)

Query: 79   KPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPP 138
            +P AS  A + S   AL+PA  + S  S+   ++   +   S S++      SS+     
Sbjct: 2508 EPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSS 2567

Query: 139  KPMS--LKTERINSGKTPPQED-REKSPPGRRQDRSPAPTGRPTPGAERRGVSEDGKIMH 195
             P+   +  +R+ S    P+E  RE  PP             PTP   +R          
Sbjct: 2568 LPVQPEVALKRVPSPTPAPKEAVREGRPP------------EPTPAKRKR---------- 2605

Query: 196  PSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASS 255
                       R S   +S +++    ++++  +  SSS   SS     S   +   A  
Sbjct: 2606 -----------RSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654

Query: 256  APDSAERQNLPVNPP 270
             P +  +   P  PP
Sbjct: 2655 GPQALPKPASPKKPP 2669



 Score = 31.6 bits (70), Expect = 1.0
 Identities = 64/281 (22%), Positives = 100/281 (35%), Gaps = 41/281 (14%)

Query: 9   EVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADI---HRKLQSHMDALRKQNRELREE 65
           ++P+  S+    PS Q    S H     +    A     HR++ S   +  + +   + +
Sbjct: 411 KLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRD 470

Query: 66  LRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATL 125
                      G+  + SP   +   + +  P   K  H       +P++  R+S+SA  
Sbjct: 471 KSHSHTPSRRMGR--SRSPATAKRGRSRSRTPT--KRGH---SRSRSPQW--RRSRSA-- 519

Query: 126 LGQRWSSNHL--------APPKP---MSLKTER---INSGKTPPQEDREKSPPGRRQDRS 171
             QRW  +          +P +P    S  T+R     S +      R  +  GR + R+
Sbjct: 520 --QRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRT 577

Query: 172 PAPTGRP---TPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQA-------SQATTLQE 221
           PA  GR    TP A RR  S         SR+P   G  +S   A       S       
Sbjct: 578 PARRGRSRSRTP-ARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSR 636

Query: 222 QTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAER 262
             + AR + RS S   +  G   SR  A    S +   A R
Sbjct: 637 SRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARR 677



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 29/110 (26%), Positives = 41/110 (37%), Gaps = 16/110 (14%)

Query: 154  PPQEDREKSPPGRRQDRSPAPT-GRP-----------TPGAERRGVSEDGKIMHPSSRSP 201
            PPQED   SPP ++   SP P   RP           TP  ER G     +    +S  P
Sbjct: 1171 PPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALP 1230

Query: 202  QNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADE 251
             +S       +  +     E+ A    +  SS +   S   F S  + +E
Sbjct: 1231 TSS----QDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEE 1276



 Score = 30.4 bits (67), Expect = 2.2
 Identities = 57/269 (21%), Positives = 96/269 (35%), Gaps = 34/269 (12%)

Query: 56  RKQNRELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKI-----SHLSADED 110
           R+++R      RG  R +  A ++        R S + +     G+      +       
Sbjct: 601 RRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRS 660

Query: 111 TTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPP----GR 166
            TP   GR S+S T   +   S    P +       R  S    P+  R +S      GR
Sbjct: 661 RTPARRGR-SRSRTPARRSGRSRSRTPAR-------RGRSRSRTPRRGRSRSRSLVRRGR 712

Query: 167 RQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAA 226
              R+P   GR    +ER+  S   +    S+ SP+    +KS + + ++ +L    + A
Sbjct: 713 SHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEM---KKSRISSRRSRSLSSPRSKA 769

Query: 227 RG-ADRSSSVLGSS---EGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTK 282
           +       S+ GSS   +    +  +     SS P +  R      PP     + +   K
Sbjct: 770 KSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSR-----TPPRRSRSSSSPPPK 824

Query: 283 MKKEEVQEEKR-----HPKGKADDCRRSG 306
            K +    +       HPK K+    R G
Sbjct: 825 QKSKTPSRQSHSSSSPHPKVKSGTPPRQG 853


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 9/117 (7%)

Query: 19   EMPSLQQQITSLHQELGRQQSLWADIHRKLQ-----SHMDALRKQNRELREELRGLQRQQ 73
            E   LQ Q+  L  +L +++   A  H KLQ     +H DA ++QN+EL+E+LR L++ Q
Sbjct: 1585 EAQRLQAQLNELQAQLSQKEQ--AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642

Query: 74   WEAGKKPAASPHAGRESHTLAL--EPAFGKISHLSADEDTTPKYAGRKSQSATLLGQ 128
             E  +  A +   G E     L  + A     HL+A   +         Q    LG+
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 77/316 (24%), Positives = 110/316 (34%), Gaps = 68/316 (21%)

Query: 25  QQITSLHQELGRQQSLWADIHRK---LQSHMDALRKQNRELREELRGLQRQQWEAGKKP- 80
           + +  L+  +  QQ L     R+   L+  +D L ++NR+LREE    Q  + E  + P 
Sbjct: 21  EYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREES---QLHRGELHRDPH 77

Query: 81  AASPHAGRESHTLAL---------------------------EPAFGKISHLSADEDTTP 113
            A    GRES    L                           E A+     +  D++   
Sbjct: 78  GARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNREGAYQNREAVYRDKERDA 137

Query: 114 KYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPA 173
            Y  + +   T   +  +  HL    P +L  ER      P    REK         S A
Sbjct: 138 SYPLQDTTGYTARERDVAQCHLHHENP-ALGRERGGREAGPAHPGREKEA-----GYSAA 191

Query: 174 PTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSS 233
               P P  ER  +S         S SP   GG  +    S ATTLQ ++       R+ 
Sbjct: 192 VGVGPRPPRERGQLSRGAS----RSSSPGAGGGHSTSTSTSPATTLQRKSDGEN--SRTV 245

Query: 234 SVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIA----------------Q 277
           SV G + G  LS       A  +P S     L   PPSS  +                 Q
Sbjct: 246 SVEGDAPGSDLST------AVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQ 299

Query: 278 AMDTKMKKEEVQEEKR 293
                ++K+E +E KR
Sbjct: 300 PASVALRKQEEEEIKR 315


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 52/215 (24%), Positives = 82/215 (38%), Gaps = 30/215 (13%)

Query: 89  ESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMS----LK 144
           E  T+ L+P     + L+     +P +  ++S SA    +R+S     P  P S     K
Sbjct: 369 EGDTITLKPR--PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKK 426

Query: 145 TERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVS---EDGKIMHPSSRSP 201
           T+  N+    P+EDRE    GR+   +      P PG ER+  +       ++  S+   
Sbjct: 427 TQSNNAENKRPEEDRES---GRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRS 483

Query: 202 QNS---------------GGRKSPVQASQATTLQEQTA--AARGADRSSSVLGSSEGGFL 244
           +NS               G     +  S+A+T     A  AAR      S+  S      
Sbjct: 484 RNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKA 543

Query: 245 SRVQADEFASSAP-DSAERQNLPVNPPSSLEIAQA 278
           S +   E     P  S   Q +PV  PS+  I+ +
Sbjct: 544 SGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSS 578


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 50/202 (24%), Positives = 80/202 (39%), Gaps = 24/202 (11%)

Query: 89  ESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMS----LK 144
           E  T+ L+P     + L+     +P +  ++S SA    +R+S     P  P S     K
Sbjct: 369 EGDTITLKPR--PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKK 426

Query: 145 TERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVS---EDGKIMHPSSRSP 201
           T+  N+    P+EDRE    GR+   +      P PG ER+  +       ++  S+   
Sbjct: 427 TQSNNAENKRPEEDRES---GRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRS 483

Query: 202 QNSG-------GRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSR---VQADE 251
           +NS        G+ S      +T  Q    A+  A   SS  G+ +     R    ++  
Sbjct: 484 RNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTF 543

Query: 252 FASSAPDSAERQNLP--VNPPS 271
            A       ++QNLP  V P S
Sbjct: 544 HAGQLRQVRDQQNLPYGVTPAS 565


>gi|23308697 signal recognition particle receptor [Homo sapiens]
          Length = 638

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 10/127 (7%)

Query: 185 RGVSEDGKIMHPSSRSP-QNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGF 243
           R   E  KI  P++    ++S   K PV++   T  ++    A+ + +  +    S+G  
Sbjct: 122 REAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDG-- 179

Query: 244 LSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKADDCR 303
                    A+S P  AE+  LPV P + +E+++    + K+EE  ++      K++   
Sbjct: 180 -------PLATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKST 232

Query: 304 RSGFPSE 310
           +S  P E
Sbjct: 233 KSDAPKE 239


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 54/217 (24%), Positives = 86/217 (39%), Gaps = 38/217 (17%)

Query: 24  QQQITSLHQELGRQQSLWADIH--------RKLQSHMDA--LRKQNRE-----LREELRG 68
           +Q    LH+ + +QQ + A  H        RKL+ H     L KQ+RE     L+ + +G
Sbjct: 102 RQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG 161

Query: 69  -----------LQRQQWEAGKKPAASPHAGRESHTLALEPAF--GKISHLSADEDTTPKY 115
                      ++ Q++   KK A +      +H ++ +P +  GK  H S D+ + P+ 
Sbjct: 162 KESAVASTEVKMKLQEFVLNKKKALAHR--NLNHCISSDPRYWYGKTQHSSLDQSSPPQS 219

Query: 116 AGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPT 175
               S +  +LG   + +     K  S    ++ S       +R  SP  RR+D  P  T
Sbjct: 220 GVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKD-GPVVT 278

Query: 176 G---RPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKS 209
               RP    +    S  G        SP NS G  S
Sbjct: 279 ALKKRPLDVTDSACSSAPGS----GPSSPNNSSGSVS 311


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 39/130 (30%), Positives = 53/130 (40%), Gaps = 20/130 (15%)

Query: 138 PKPMSLKTERINS------GKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDG 191
           P P+  K  RI++      GK      R     G R+D S    G P+P   RR  +   
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 192 KI----MHPSSR-SPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSR 246
           ++      PS+R  P   G RKS   AS+ +T +   AA R           S GG L R
Sbjct: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR---------RPSAGGGLQR 236

Query: 247 VQADEFASSA 256
             +   +SSA
Sbjct: 237 PASRSLSSSA 246


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 39/130 (30%), Positives = 53/130 (40%), Gaps = 20/130 (15%)

Query: 138 PKPMSLKTERINS------GKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDG 191
           P P+  K  RI++      GK      R     G R+D S    G P+P   RR  +   
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 192 KI----MHPSSR-SPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSR 246
           ++      PS+R  P   G RKS   AS+ +T +   AA R           S GG L R
Sbjct: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR---------RPSAGGGLQR 236

Query: 247 VQADEFASSA 256
             +   +SSA
Sbjct: 237 PASRSLSSSA 246


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 39/130 (30%), Positives = 53/130 (40%), Gaps = 20/130 (15%)

Query: 138 PKPMSLKTERINS------GKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDG 191
           P P+  K  RI++      GK      R     G R+D S    G P+P   RR  +   
Sbjct: 117 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 176

Query: 192 KI----MHPSSR-SPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSR 246
           ++      PS+R  P   G RKS   AS+ +T +   AA R           S GG L R
Sbjct: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR---------RPSAGGGLQR 227

Query: 247 VQADEFASSA 256
             +   +SSA
Sbjct: 228 PASRSLSSSA 237


>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 1 [Homo sapiens]
          Length = 559

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 63/302 (20%), Positives = 106/302 (35%), Gaps = 30/302 (9%)

Query: 32  QELGRQQSLWADIHRKLQSHMDALRKQNRELREELRGLQRQQWEAGKKPAASPHAGRESH 91
           ++  ++ S  +  H+  + H +  RK + E +   + L+R+Q ++ K  +     GR   
Sbjct: 182 KDANKESSKTSKPHKVTKEHRERPRKDS-ESKSSSKELEREQAKSSKDTSRKLGEGR--- 237

Query: 92  TLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSG 151
                        L  +E   P  A  K     L   +  S       P         S 
Sbjct: 238 -------------LPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASS 284

Query: 152 KTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRK--- 208
           K P   D  K P  ++Q +S +   R  PG   R  S         ++   ++ G K   
Sbjct: 285 KRPATADSPK-PSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKA 343

Query: 209 --SPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQNLP 266
              P +A +A  ++E  +    + +S S   S      S   +   +SS  D    QN  
Sbjct: 344 ESEPREAKKALEVEESNSEDEASFKSESAQSSP-----SNSSSSSDSSSDSDFEPSQNHS 398

Query: 267 VNP-PSSLEIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSEFPGALHAA-PSRQDM 324
             P  S +E  Q+ ++        EE         D R S   SE   +  ++ PSR+  
Sbjct: 399 QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPP 458

Query: 325 GP 326
            P
Sbjct: 459 PP 460


>gi|70980547 FYVE-finger-containing Rab5 effector protein
           rabenosyn-5 [Homo sapiens]
          Length = 784

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 50/192 (26%), Positives = 77/192 (40%), Gaps = 27/192 (14%)

Query: 19  EMPSLQQQITSLHQELGRQQSLWA-DIHRKLQSHMDALRKQNRELREELRGLQRQQWEAG 77
           E+ +LQ+ +  L  E  +QQ+  A ++ R+     D  R+Q + LRE     +R+Q+   
Sbjct: 481 EVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVA 540

Query: 78  KKPAASPHAG-RESHTLALEPAFGKISHLS---------ADEDTTPKYAGRKSQSATLLG 127
                +     RE     LEP+    +HL+             T PK     S S+T   
Sbjct: 541 SLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPK---TPSLSSTQPT 597

Query: 128 QRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGV 187
           + WS        P ++  ER+     P Q +     P   +D S +P    T G    GV
Sbjct: 598 RVWSG-------PPAVGQERLPQSSMPQQHEGPSLNPFDEEDLS-SPMEEATTGPPAAGV 649

Query: 188 SEDGKIMHPSSR 199
           S D     PS+R
Sbjct: 650 SLD-----PSAR 656


>gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo
           sapiens]
          Length = 559

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 53/185 (28%), Positives = 78/185 (42%), Gaps = 23/185 (12%)

Query: 46  RKLQSHMDALRKQNRELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKI-SH 104
           R  + H  AL ++ R  REEL G Q  +    +K AASP   + +       A G++ SH
Sbjct: 103 RAKEKHRAALSEE-RSCREEL-GQQHPRHSRPRKTAASPEKPQTTK------ATGRMNSH 154

Query: 105 LSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINS-----GKTPPQEDR 159
           L+  E    K  GR   S    G R +   + P +      ER N      G+    E++
Sbjct: 155 LAPPE----KRKGRPEPSTKSGGGRCA---IHPRRSKGADLERSNPLVAAVGEIGLVEEK 207

Query: 160 EKSP--PGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQAT 217
           EK     GRRQ    A    P   +  +G S +GK+       P +S  R+  V  +   
Sbjct: 208 EKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCRREAVSPASQC 267

Query: 218 TLQEQ 222
           TL+E+
Sbjct: 268 TLREK 272


>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 37/133 (27%), Positives = 54/133 (40%), Gaps = 4/133 (3%)

Query: 183 ERRGVSEDGKIMHPSSRSPQNSGGRKSPVQ--ASQATTLQEQTAAARGADRSSSVLGSSE 240
           E RG   +    H  SRSP +S  R    Q  ASQA+      + +    RSSS    S 
Sbjct: 227 EVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISS 286

Query: 241 GGFLSRVQADEFASSAPDSAER--QNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGK 298
               S   +D  +SS+ DS  R  Q+  V  P+S  ++     + +K    + +  P   
Sbjct: 287 SSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRS 346

Query: 299 ADDCRRSGFPSEF 311
            D   + G   EF
Sbjct: 347 TDTSLKDGLFHEF 359


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 54/250 (21%), Positives = 94/250 (37%), Gaps = 35/250 (14%)

Query: 94  ALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKT 153
           +++PA  K S +S  E    K A    +   +  Q        PP   + K E  +    
Sbjct: 217 SVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSE 274

Query: 154 PPQEDREKSPPGRR----------QDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQN 203
              E  E++P G R          Q R+ +   + TPG +    +  GK    +S++   
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-KGATPAPPGKAGAVASQTKAG 333

Query: 204 SGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQ 263
                S   + +++  +E+T AA+      ++L +   G  S+V A   AS+    + R+
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAK------ALLQAKASGKTSQVGA---ASAPAKESPRK 384

Query: 264 NLPVNPPSSL-------------EIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSE 310
                PP                E +Q+   +   EE    +  P GKA   R +  P++
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444

Query: 311 FPGALHAAPS 320
                 AAP+
Sbjct: 445 ESPRKGAAPA 454



 Score = 32.7 bits (73), Expect = 0.45
 Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 38/164 (23%)

Query: 97  PAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQ 156
           P+ GK    +A   T P+     S+  +       +  LA  KP S KT +I +   P +
Sbjct: 848 PSVGKAVATAAQAQTGPEEDSGSSEEES--DSEEEAETLAQVKP-SGKTHQIRAALAPAK 904

Query: 157 EDREKSPPGRRQDRSPAPTGRPTPGAERRGVSED--------------------GKIMHP 196
           E    SP   R+  +P P G+  P A + G  +D                     +++ P
Sbjct: 905 E----SP---RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957

Query: 197 ------SSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSS 234
                  +RSP  +G   +P QA  A+T ++  A+   A  SSS
Sbjct: 958 PLIFVDPNRSP--AGPAATPAQAQAASTPRKARASESTARSSSS 999


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 54/250 (21%), Positives = 94/250 (37%), Gaps = 35/250 (14%)

Query: 94  ALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKT 153
           +++PA  K S +S  E    K A    +   +  Q        PP   + K E  +    
Sbjct: 217 SVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSE 274

Query: 154 PPQEDREKSPPGRR----------QDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQN 203
              E  E++P G R          Q R+ +   + TPG +    +  GK    +S++   
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-KGATPAPPGKAGAVASQTKAG 333

Query: 204 SGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQ 263
                S   + +++  +E+T AA+      ++L +   G  S+V A   AS+    + R+
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAK------ALLQAKASGKTSQVGA---ASAPAKESPRK 384

Query: 264 NLPVNPPSSL-------------EIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSE 310
                PP                E +Q+   +   EE    +  P GKA   R +  P++
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444

Query: 311 FPGALHAAPS 320
                 AAP+
Sbjct: 445 ESPRKGAAPA 454



 Score = 32.7 bits (73), Expect = 0.45
 Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 38/164 (23%)

Query: 97  PAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQ 156
           P+ GK    +A   T P+     S+  +       +  LA  KP S KT +I +   P +
Sbjct: 848 PSVGKAVATAAQAQTGPEEDSGSSEEES--DSEEEAETLAQVKP-SGKTHQIRAALAPAK 904

Query: 157 EDREKSPPGRRQDRSPAPTGRPTPGAERRGVSED--------------------GKIMHP 196
           E    SP   R+  +P P G+  P A + G  +D                     +++ P
Sbjct: 905 E----SP---RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957

Query: 197 ------SSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSS 234
                  +RSP  +G   +P QA  A+T ++  A+   A  SSS
Sbjct: 958 PLIFVDPNRSP--AGPAATPAQAQAASTPRKARASESTARSSSS 999


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 54/250 (21%), Positives = 94/250 (37%), Gaps = 35/250 (14%)

Query: 94  ALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKT 153
           +++PA  K S +S  E    K A    +   +  Q        PP   + K E  +    
Sbjct: 217 SVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSE 274

Query: 154 PPQEDREKSPPGRR----------QDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQN 203
              E  E++P G R          Q R+ +   + TPG +    +  GK    +S++   
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-KGATPAPPGKAGAVASQTKAG 333

Query: 204 SGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQ 263
                S   + +++  +E+T AA+      ++L +   G  S+V A   AS+    + R+
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAK------ALLQAKASGKTSQVGA---ASAPAKESPRK 384

Query: 264 NLPVNPPSSL-------------EIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSE 310
                PP                E +Q+   +   EE    +  P GKA   R +  P++
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444

Query: 311 FPGALHAAPS 320
                 AAP+
Sbjct: 445 ESPRKGAAPA 454



 Score = 32.7 bits (73), Expect = 0.45
 Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 38/164 (23%)

Query: 97  PAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQ 156
           P+ GK    +A   T P+     S+  +       +  LA  KP S KT +I +   P +
Sbjct: 848 PSVGKAVATAAQAQTGPEEDSGSSEEES--DSEEEAETLAQVKP-SGKTHQIRAALAPAK 904

Query: 157 EDREKSPPGRRQDRSPAPTGRPTPGAERRGVSED--------------------GKIMHP 196
           E    SP   R+  +P P G+  P A + G  +D                     +++ P
Sbjct: 905 E----SP---RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957

Query: 197 ------SSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSS 234
                  +RSP  +G   +P QA  A+T ++  A+   A  SSS
Sbjct: 958 PLIFVDPNRSP--AGPAATPAQAQAASTPRKARASESTARSSSS 999


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 54/250 (21%), Positives = 94/250 (37%), Gaps = 35/250 (14%)

Query: 94  ALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKT 153
           +++PA  K S +S  E    K A    +   +  Q        PP   + K E  +    
Sbjct: 217 SVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSE 274

Query: 154 PPQEDREKSPPGRR----------QDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQN 203
              E  E++P G R          Q R+ +   + TPG +    +  GK    +S++   
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-KGATPAPPGKAGAVASQTKAG 333

Query: 204 SGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQ 263
                S   + +++  +E+T AA+      ++L +   G  S+V A   AS+    + R+
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAK------ALLQAKASGKTSQVGA---ASAPAKESPRK 384

Query: 264 NLPVNPPSSL-------------EIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSE 310
                PP                E +Q+   +   EE    +  P GKA   R +  P++
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444

Query: 311 FPGALHAAPS 320
                 AAP+
Sbjct: 445 ESPRKGAAPA 454



 Score = 31.6 bits (70), Expect = 1.0
 Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 13/119 (10%)

Query: 97  PAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQ 156
           P+ GK    +A   T P+     S+  +       +  LA  KP S KT +I +   P +
Sbjct: 848 PSVGKAVATAAQAQTGPEEDSGSSEEES--DSEEEAETLAQVKP-SGKTHQIRAALAPAK 904

Query: 157 EDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQ 215
           E    SP   R+  +P P G+  P A + G  +D      SS    + G   + V ++Q
Sbjct: 905 E----SP---RKGAAPTPPGKTGPSAAQAGKQDDS---GSSSEESDSDGEAPAAVTSAQ 953


>gi|29893555 angiopoietin-like 6 [Homo sapiens]
          Length = 470

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 54/220 (24%), Positives = 88/220 (40%), Gaps = 41/220 (18%)

Query: 5   PAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRELRE 64
           PA+     E +NA E+ +L+ ++   H+EL R+    A     +   + ALRK++R L  
Sbjct: 47  PASTRATPEAANASELAALRMRV-GRHEELLRELQRLAAADGAVAGEVRALRKESRGLSA 105

Query: 65  ELRGLQRQ-QWEAGKKPAASPHAGRESHTLALEPAFG-KISHLSADEDTTP--------- 113
            L  L+ Q Q EAG  P A P A   +   A     G ++ + SA+              
Sbjct: 106 RLGQLRAQLQHEAG--PGAGPGADLGAEPAAALALLGERVLNASAEAQRAAARFHQLDVK 163

Query: 114 --KYAGRKSQSATLL--------GQRWSSNHLAPPKPM-----------SLKTERINSGK 152
             + A   +Q ++L+        G       + PP P+           +  T R+    
Sbjct: 164 FRELAQLVTQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLVGSTSDTSRMLDPA 223

Query: 153 TPPQEDREKSPPGRRQD--RSPAPTGRPTPGAERRGVSED 190
             PQ D+ +    R+Q+   SP P G P    +  G  +D
Sbjct: 224 PEPQRDQTQ----RQQEPMASPMPAGHPAVPTKPVGPWQD 259


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score = 37.7 bits (86), Expect = 0.014
 Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 31/215 (14%)

Query: 89  ESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMS----LK 144
           E  T+ L+P     + L+     +P +  ++S SA    +R+S +   P  P S     K
Sbjct: 336 EGDTITLKPR--PSADLTNSSAPSPSHKVQRSVSANPKQRRFS-DQAGPAIPTSNSYSKK 392

Query: 145 TERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVS---EDGKIMHPSSRSP 201
           T+  N+    P+EDRE    GR+   +      P PG ER+  +       ++  S+   
Sbjct: 393 TQSNNAENKRPEEDRES---GRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRS 449

Query: 202 QNS---------------GGRKSPVQASQATTLQEQTA--AARGADRSSSVLGSSEGGFL 244
           +NS               G     +  S+A+T     A  AAR      S+  S      
Sbjct: 450 RNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKA 509

Query: 245 SRVQADEFASSAP-DSAERQNLPVNPPSSLEIAQA 278
           S +   E     P  S   Q +PV  PS+  I+ +
Sbjct: 510 SGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSS 544


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score = 37.7 bits (86), Expect = 0.014
 Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 2/137 (1%)

Query: 106 SADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPG 165
           S +ED+  K + R+S+S +      SS+  + P   S    R  S  +   + R +S   
Sbjct: 188 SEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSS-SRSRSRSRSRSSSSSQSRSRSS-S 245

Query: 166 RRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAA 225
           R + RS     R +  + R   S   +    SS SP+ +  R     +S     + +T +
Sbjct: 246 RERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRS 305

Query: 226 ARGADRSSSVLGSSEGG 242
                R  S  GSS  G
Sbjct: 306 RSPERRHRSSSGSSHSG 322


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.123    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,284,833
Number of Sequences: 37866
Number of extensions: 846933
Number of successful extensions: 5874
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 543
Number of HSP's that attempted gapping in prelim test: 5033
Number of HSP's gapped (non-prelim): 1343
length of query: 326
length of database: 18,247,518
effective HSP length: 103
effective length of query: 223
effective length of database: 14,347,320
effective search space: 3199452360
effective search space used: 3199452360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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