Search of human proteins with 186910311

Search of human proteins with 186910311

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|186910311 SIX homeobox 6 [Homo sapiens]
         (246 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|186910311 SIX homeobox 6 [Homo sapiens]                            501   e-142
gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens]              411   e-115
gi|219275578 SIX homeobox 2 [Homo sapiens]                            285   3e-77
gi|5174681 SIX homeobox 1 [Homo sapiens]                              280   1e-75
gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens]            229   2e-60
gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]             211   4e-55
gi|57863281 Meis1, myeloid ecotropic viral integration site 1 ho...    53   2e-07
gi|4505151 Meis homeobox 1 [Homo sapiens]                              52   6e-07
gi|57863279 Meis1, myeloid ecotropic viral integration site 1 ho...    51   1e-06
gi|27502383 Meis homeobox 2 isoform h [Homo sapiens]                   50   1e-06
gi|27502381 Meis homeobox 2 isoform g [Homo sapiens]                   50   1e-06
gi|24762244 Meis homeobox 2 isoform a [Homo sapiens]                   50   1e-06
gi|24762250 Meis homeobox 2 isoform d [Homo sapiens]                   50   1e-06
gi|24762241 Meis homeobox 2 isoform c [Homo sapiens]                   50   1e-06
gi|24762246 Meis homeobox 2 isoform b [Homo sapiens]                   50   1e-06
gi|24762225 Meis homeobox 2 isoform f [Homo sapiens]                   50   1e-06
gi|4505623 pre-B-cell leukemia homeobox 1 [Homo sapiens]               50   2e-06
gi|15149472 pre-B-cell leukemia homeobox 4 [Homo sapiens]              49   4e-06
gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens]              49   4e-06
gi|21956641 ISL LIM homeobox 2 [Homo sapiens]                          48   9e-06
gi|198041755 pre-B-cell leukemia homeobox 3 isoform 2 [Homo sapi...    47   2e-05
gi|5453852 pre-B-cell leukemia homeobox 3 isoform 1 [Homo sapiens]     47   2e-05
gi|115387114 islet-1 [Homo sapiens]                                    47   2e-05
gi|61969664 divergent-paired related homeobox [Homo sapiens]           46   3e-05
gi|116812644 PBX/knotted 1 homeobox 2 [Homo sapiens]                   45   6e-05
gi|118766339 thyroid transcription factor 1 isoform 1 [Homo sapi...    44   1e-04
gi|4507715 thyroid transcription factor 1 isoform 2 [Homo sapiens]     44   1e-04
gi|4557489 cone-rod homeobox protein [Homo sapiens]                    43   2e-04
gi|28866955 PBX/knotted 1 homeobox 1 [Homo sapiens]                    43   3e-04
gi|4826912 paired-like homeodomain 3 [Homo sapiens]                    42   4e-04

>gi|186910311 SIX homeobox 6 [Homo sapiens]
          Length = 246

 Score =  501 bits (1289), Expect = e-142
 Identities = 246/246 (100%), Positives = 246/246 (100%)

Query: 1   MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV 60
           MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV
Sbjct: 1   MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV 60

Query: 61  AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 120
           AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP
Sbjct: 61  AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 120

Query: 121 LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 180
           LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR
Sbjct: 121 LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 180

Query: 181 QRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTPEVLGVATSPAASLSSKAATSAISITSS 240
           QRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTPEVLGVATSPAASLSSKAATSAISITSS
Sbjct: 181 QRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTPEVLGVATSPAASLSSKAATSAISITSS 240

Query: 241 DSECDI 246
           DSECDI
Sbjct: 241 DSECDI 246


>gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens]
          Length = 332

 Score =  411 bits (1057), Expect = e-115
 Identities = 200/254 (78%), Positives = 217/254 (85%), Gaps = 8/254 (3%)

Query: 1   MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV 60
           MFQLP LNFSP+QVA VCETLEE+GD+ERLGRFLWSLPVAP ACEA+NK+ES+LRARA+V
Sbjct: 79  MFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVV 138

Query: 61  AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 120
           AFH GN+R+LYHILENHKFTKESH KLQA+WLEAHYQEAEKLRGRPLGPVDKYRVRKKFP
Sbjct: 139 AFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 198

Query: 121 LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 180
           LPRTIWDGEQKTHCFKERTR LLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR
Sbjct: 199 LPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 258

Query: 181 QRDRAAAAKNRLQQQVLSQGSGRALRAEG---DGTPEVLGVATSPAASLSS-----KAAT 232
           QRDRAAAAKNRLQ Q +     R+L   G    G+ E    A SP  S+SS        T
Sbjct: 259 QRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGT 318

Query: 233 SAISITSSDSECDI 246
           S +S+TSSDSECD+
Sbjct: 319 SILSVTSSDSECDV 332


>gi|219275578 SIX homeobox 2 [Homo sapiens]
          Length = 291

 Score =  285 bits (729), Expect = 3e-77
 Identities = 143/240 (59%), Positives = 176/240 (73%), Gaps = 19/240 (7%)

Query: 1   MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV 60
           M  LP   F+ +QVA VCE L++ G++ERLGRFLWSLP    ACE L+KNESVL+A+A+V
Sbjct: 1   MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLP----ACEHLHKNESVLKAKAVV 56

Query: 61  AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 120
           AFH GN+RELY ILE+H+F+  +HAKLQ LWL+AHY EAEKLRGRPLG V KYRVR+KFP
Sbjct: 57  AFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFP 116

Query: 121 LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 180
           LPR+IWDGE+ ++CFKE++R +LREWY  +PYP+P +KRELA+ATGLT TQV NWFKNRR
Sbjct: 117 LPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRR 176

Query: 181 QRDRAAAAKNRLQQQVLSQGSGRALRAEG-------------DGTPEVLGVATSPAASLS 227
           QRDRAA AK R   +  +  S   L   G              GTP+    ++SPA  LS
Sbjct: 177 QRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPD--HSSSSPALLLS 234


>gi|5174681 SIX homeobox 1 [Homo sapiens]
          Length = 284

 Score =  280 bits (715), Expect = 1e-75
 Identities = 131/191 (68%), Positives = 159/191 (83%), Gaps = 4/191 (2%)

Query: 1   MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIV 60
           M  LP   F+ +QVA VCE L++ G++ERLGRFLWSLP    AC+ L+KNESVL+A+A+V
Sbjct: 1   MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLP----ACDHLHKNESVLKAKAVV 56

Query: 61  AFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFP 120
           AFH GN+RELY ILE+H+F+  +H KLQ LWL+AHY EAEKLRGRPLG V KYRVR+KFP
Sbjct: 57  AFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFP 116

Query: 121 LPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 180
           LPRTIWDGE+ ++CFKE++R +LREWY  +PYP+P +KRELA+ATGLT TQV NWFKNRR
Sbjct: 117 LPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRR 176

Query: 181 QRDRAAAAKNR 191
           QRDRAA AK R
Sbjct: 177 QRDRAAEAKER 187


>gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens]
          Length = 781

 Score =  229 bits (583), Expect = 2e-60
 Identities = 109/178 (61%), Positives = 137/178 (76%), Gaps = 4/178 (2%)

Query: 7   LNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGN 66
           L FSP  VA VCE L++ G+++RL RFLWSLP +    + L  NES+L+ARA+VAFH G 
Sbjct: 106 LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQS----DLLRGNESLLKARALVAFHQGI 161

Query: 67  YRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIW 126
           Y ELY ILE+H F   +H  LQ LW +A Y EAE+ RGRPLG VDKYR+R+KFPLPRTIW
Sbjct: 162 YPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIW 221

Query: 127 DGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDR 184
           DGE+  +CFKE++R+ L+E Y Q+ YP+P++KR LA+ TGL+ TQV NWFKNRRQRDR
Sbjct: 222 DGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDR 279


>gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]
          Length = 739

 Score =  211 bits (538), Expect = 4e-55
 Identities = 112/207 (54%), Positives = 134/207 (64%), Gaps = 16/207 (7%)

Query: 7   LNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGN 66
           L FSP+QVA VCE L ++G   RL RFL +LP A    E L  ++ VLRARA+VAF  G 
Sbjct: 84  LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPA----ERLRGSDPVLRARALVAFQRGE 139

Query: 67  YRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIW 126
           Y ELY +LE+  F    HA LQ L+L A Y EAE+ RGR LG VDKYR+RKKFPLP+TIW
Sbjct: 140 YAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIW 199

Query: 127 DGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAA 186
           DGE+  +CFKER+R  L+  Y  + YP P +KR LA  TGL+ TQV NWFKNRRQRDR  
Sbjct: 200 DGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTG 259

Query: 187 AAKNRLQQQVLSQGSGRALRAEGDGTP 213
           A            G G   ++E DG P
Sbjct: 260 A------------GGGAPCKSESDGNP 274


>gi|57863281 Meis1, myeloid ecotropic viral integration site 1
           homolog 3 isoform 1 [Homo sapiens]
          Length = 421

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 29/68 (42%), Positives = 38/68 (55%), Gaps = 13/68 (19%)

Query: 146 WYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQ----GS 201
           W+LQ PYP+  +K++LAQ TGLT  QV NWF N         A+ R+ Q ++ Q    G 
Sbjct: 329 WWLQHPYPSEEQKKQLAQDTGLTILQVNNWFIN---------ARRRIVQPMIDQSNRTGQ 379

Query: 202 GRALRAEG 209
           G A   EG
Sbjct: 380 GAAFSPEG 387


>gi|4505151 Meis homeobox 1 [Homo sapiens]
          Length = 390

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 20/94 (21%)

Query: 127 DGEQKTH----CFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNR 179
           D ++K H     F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N 
Sbjct: 267 DKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFIN- 325

Query: 180 RQRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTP 213
                   A+ R+ Q ++ Q +    RA   GTP
Sbjct: 326 --------ARRRIVQPMIDQSN----RAVSQGTP 347


>gi|57863279 Meis1, myeloid ecotropic viral integration site 1
           homolog 3 isoform 2 [Homo sapiens]
          Length = 358

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 16/87 (18%)

Query: 130 QKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAA 186
           +K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N        
Sbjct: 247 KKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFIN-------- 298

Query: 187 AAKNRLQQQVLSQ----GSGRALRAEG 209
            A+ R+ Q ++ Q    G G A   EG
Sbjct: 299 -ARRRIVQPMIDQSNRTGQGAAFSPEG 324


>gi|27502383 Meis homeobox 2 isoform h [Homo sapiens]
          Length = 306

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 189 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 245


>gi|27502381 Meis homeobox 2 isoform g [Homo sapiens]
          Length = 388

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 264 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 320


>gi|24762244 Meis homeobox 2 isoform a [Homo sapiens]
          Length = 401

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 277 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333


>gi|24762250 Meis homeobox 2 isoform d [Homo sapiens]
          Length = 470

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 277 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333


>gi|24762241 Meis homeobox 2 isoform c [Homo sapiens]
          Length = 477

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 277 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333


>gi|24762246 Meis homeobox 2 isoform b [Homo sapiens]
          Length = 394

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 277 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333


>gi|24762225 Meis homeobox 2 isoform f [Homo sapiens]
          Length = 381

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           ++K   F +   +++R W   +L  PYP+  +K++LAQ TGLT  QV NWF N R+R
Sbjct: 264 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 320


>gi|4505623 pre-B-cell leukemia homeobox 1 [Homo sapiens]
          Length = 430

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 11/106 (10%)

Query: 127 DGEQKTHCFKERTRHLLREWY---LQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRD 183
           D  +K   F ++   +L E++   L +PYP+   K ELA+  G+T +QV NWF N+R R 
Sbjct: 232 DARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRY 291

Query: 184 RAAAAKNRLQQQV--------LSQGSGRALRAEGDGTPEVLGVATS 221
           +    K + +  +         +  S    +A    TP   G ++S
Sbjct: 292 KKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSS 337


>gi|15149472 pre-B-cell leukemia homeobox 4 [Homo sapiens]
          Length = 374

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 3/59 (5%)

Query: 127 DGEQKTHCFKERTRHLLREWY---LQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           D  +K   F ++   +L E++   L +PYP+   K ELA+  GLT +QV NWF N+R R
Sbjct: 209 DARRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIR 267


>gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens]
          Length = 430

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 23/59 (38%), Positives = 35/59 (59%), Gaps = 3/59 (5%)

Query: 127 DGEQKTHCFKERTRHLLREWY---LQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           D  +K   F ++   +L E++   L +PYP+   K ELA+  G+T +QV NWF N+R R
Sbjct: 243 DARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIR 301


>gi|21956641 ISL LIM homeobox 2 [Homo sapiens]
          Length = 359

 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 4/82 (4%)

Query: 137 ERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQV 196
           E+  H LR  Y  +P P+   K +L + TGL+P  +  WF+N+R +D+    K+ L +Q+
Sbjct: 200 EKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDK---KKSILMKQL 256

Query: 197 LSQGSGRALRAEG-DGTPEVLG 217
             Q        +G  GTP V G
Sbjct: 257 QQQQHSDKTSLQGLTGTPLVAG 278


>gi|198041755 pre-B-cell leukemia homeobox 3 isoform 2 [Homo
           sapiens]
          Length = 359

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 3/59 (5%)

Query: 127 DGEQKTHCFKERTRHLLREWY---LQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           D  +K   F ++   +L E++   L +PYP+   K ELA+   +T +QV NWF N+R R
Sbjct: 159 DARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIR 217


>gi|5453852 pre-B-cell leukemia homeobox 3 isoform 1 [Homo sapiens]
          Length = 434

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 3/59 (5%)

Query: 127 DGEQKTHCFKERTRHLLREWY---LQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           D  +K   F ++   +L E++   L +PYP+   K ELA+   +T +QV NWF N+R R
Sbjct: 234 DARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIR 292


>gi|115387114 islet-1 [Homo sapiens]
          Length = 349

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 35/173 (20%)

Query: 48  NKNESVLRARAIVAFHGGNYR-----------ELYHILENHKFTKESHAKLQALWLEAHY 96
           +KN+ V+RAR+ V +H   +R           + + + E+  F +  H  ++   L A  
Sbjct: 87  SKNDFVMRARSKV-YHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGA-- 143

Query: 97  QEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFK-------------ERTRHLL 143
                  G PL P+   R  +    P +      + H  K             E+  H L
Sbjct: 144 -------GDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTL 196

Query: 144 REWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRD-RAAAAKNRLQQQ 195
           R  Y  +P P+   K +L + TGL+P  +  WF+N+R +D + +    +LQQQ
Sbjct: 197 RTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQ 249


>gi|61969664 divergent-paired related homeobox [Homo sapiens]
          Length = 191

 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 6/78 (7%)

Query: 128 GEQKTHCFKERTRHLLREW------YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQ 181
           G+ + H  ++RT    ++       + ++PYPNPS ++E+A    + PT +  WFKN R 
Sbjct: 10  GKDQMHSHRKRTMFTKKQLEDLNILFNENPYPNPSLQKEMASKIDIHPTVLQVWFKNHRA 69

Query: 182 RDRAAAAKNRLQQQVLSQ 199
           + + A  K+  Q+Q   Q
Sbjct: 70  KLKKAKCKHIHQKQETPQ 87


>gi|116812644 PBX/knotted 1 homeobox 2 [Homo sapiens]
          Length = 472

 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREW---YLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           + K     +   +++R W   +L  PYP   +KR++A  T LT  QV NWF N R+R
Sbjct: 289 KNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345


>gi|118766339 thyroid transcription factor 1 isoform 1 [Homo
           sapiens]
          Length = 401

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 1/80 (1%)

Query: 135 FKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQ 194
           F +   + L   + Q  Y +  ++  LA    LTPTQV  WF+N R + +   AK++  Q
Sbjct: 198 FSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMK-RQAKDKAAQ 256

Query: 195 QVLSQGSGRALRAEGDGTPE 214
           Q L Q SG      G G P+
Sbjct: 257 QQLQQDSGGGGGGGGTGCPQ 276


>gi|4507715 thyroid transcription factor 1 isoform 2 [Homo sapiens]
          Length = 371

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 1/80 (1%)

Query: 135 FKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQ 194
           F +   + L   + Q  Y +  ++  LA    LTPTQV  WF+N R + +   AK++  Q
Sbjct: 168 FSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMK-RQAKDKAAQ 226

Query: 195 QVLSQGSGRALRAEGDGTPE 214
           Q L Q SG      G G P+
Sbjct: 227 QQLQQDSGGGGGGGGTGCPQ 246


>gi|4557489 cone-rod homeobox protein [Homo sapiens]
          Length = 299

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 14/115 (12%)

Query: 143 LREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQ------- 195
           L   + +  YP+   + E+A    L  ++V  WFKNRR + R    + + QQQ       
Sbjct: 54  LEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAK 113

Query: 196 --VLSQGSGRALRAEGDGTPEVLGVATS-----PAASLSSKAATSAISITSSDSE 243
                + +G + R   D  P+ LG++ S     P  S S   A + +SI S  SE
Sbjct: 114 ARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASE 168


>gi|28866955 PBX/knotted 1 homeobox 1 [Homo sapiens]
          Length = 436

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 3/57 (5%)

Query: 129 EQKTHCFKERTRHLLREWYLQD---PYPNPSKKRELAQATGLTPTQVGNWFKNRRQR 182
           + K     +   +++R W  Q    PYP   +K+++A  T LT  QV NWF N R+R
Sbjct: 260 KNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRR 316


>gi|4826912 paired-like homeodomain 3 [Homo sapiens]
          Length = 302

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 27/72 (37%), Positives = 39/72 (54%), Gaps = 4/72 (5%)

Query: 130 QKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAK 189
           Q+TH F  +    L   + ++ YP+ S + E+A  T LT  +V  WFKNRR + R    +
Sbjct: 65  QRTH-FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR---KR 120

Query: 190 NRLQQQVLSQGS 201
            R QQ  L +GS
Sbjct: 121 ERSQQAELCKGS 132


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,019,239
Number of Sequences: 37866
Number of extensions: 464675
Number of successful extensions: 1674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 242
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 1367
Number of HSP's gapped (non-prelim): 336
length of query: 246
length of database: 18,247,518
effective HSP length: 100
effective length of query: 146
effective length of database: 14,460,918
effective search space: 2111294028
effective search space used: 2111294028
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.