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Search of human proteins with 18677767
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
(581 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 1174 0.0
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 1174 0.0
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 259 6e-69
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 216 4e-56
gi|225579152 insulin-like growth factor binding protein, acid la... 192 5e-49
gi|4826772 insulin-like growth factor binding protein, acid labi... 192 5e-49
gi|11321571 slit homolog 3 [Homo sapiens] 183 4e-46
gi|4759146 slit homolog 2 [Homo sapiens] 181 2e-45
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 179 5e-45
gi|188528675 slit homolog 1 [Homo sapiens] 178 1e-44
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 174 2e-43
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 170 3e-42
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 165 9e-41
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 165 9e-41
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 161 1e-39
gi|198041768 synleurin [Homo sapiens] 160 2e-39
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 159 7e-39
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 154 3e-37
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 152 8e-37
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 152 1e-36
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 149 9e-36
gi|45505137 podocan [Homo sapiens] 145 1e-34
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 140 2e-33
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 138 2e-32
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 138 2e-32
gi|153251229 chondroadherin precursor [Homo sapiens] 135 1e-31
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 134 2e-31
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 134 2e-31
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 133 4e-31
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 133 4e-31
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 1174 bits (3038), Expect = 0.0
Identities = 581/581 (100%), Positives = 581/581 (100%)
Query: 1 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 60
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
Sbjct: 7 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 66
Query: 61 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 120
LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
Sbjct: 67 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 126
Query: 121 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 180
FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
Sbjct: 127 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 186
Query: 181 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 240
GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
Sbjct: 187 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 246
Query: 241 FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL 300
FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL
Sbjct: 247 FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL 306
Query: 301 YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 360
YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
Sbjct: 307 YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 366
Query: 361 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 420
FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
Sbjct: 367 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 426
Query: 421 YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE 480
YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
Sbjct: 427 YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE 486
Query: 481 VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA 540
VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
Sbjct: 487 VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA 546
Query: 541 IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC 581
IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC
Sbjct: 547 IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC 587
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 1174 bits (3038), Expect = 0.0
Identities = 581/581 (100%), Positives = 581/581 (100%)
Query: 1 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 60
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
Sbjct: 1 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 60
Query: 61 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 120
LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
Sbjct: 61 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 120
Query: 121 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 180
FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
Sbjct: 121 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 180
Query: 181 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 240
GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
Sbjct: 181 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 240
Query: 241 FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL 300
FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL
Sbjct: 241 FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL 300
Query: 301 YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 360
YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
Sbjct: 301 YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 360
Query: 361 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 420
FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
Sbjct: 361 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 420
Query: 421 YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE 480
YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
Sbjct: 421 YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE 480
Query: 481 VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA 540
VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
Sbjct: 481 VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA 540
Query: 541 IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC 581
IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC
Sbjct: 541 IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC 581
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 259 bits (661), Expect = 6e-69
Identities = 176/531 (33%), Positives = 255/531 (48%), Gaps = 12/531 (2%)
Query: 25 CPSECTCSRASQVECTGARIVAVPT-PLPWNAMSLQILNTHITELNESPFLNISALIALR 83
CP C C +C+G + + LP N + + L F ++ L L
Sbjct: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
Query: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
I + +S + PG F +L L+ L L+ NK+ LP L + LE L L N L I
Sbjct: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
Query: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
F + NL+EL L+ N L+++P F +L L L+L N+LTH+ + L+ L
Sbjct: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
Query: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
L+ NRL + G + L L EL +N I ++PG F NL L LS NH++ LP +
Sbjct: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
Query: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL- 322
+F+ L LTLF N L EL +FG M L+ELWL + +LP F NL +L+ L
Sbjct: 261 LFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
Query: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382
+ ++S + GAF GL EL+ L+LH+N L L + R L L+ +SL+ NRLR LP
Sbjct: 321 VTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPR 380
Query: 383 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
+F N++ L ++QL +NQLE LP +F L +L E+ L N WRCD + P WL +
Sbjct: 381 ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHL 440
Query: 443 PRLGTDTVPVCFSPANVRGQSL-IIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTS 501
+G + P C P G L + + P P P P + P +P
Sbjct: 441 GLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGP--PPRPAADSSSEAPVHPALAP 498
Query: 502 VSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALA 552
SS P +TT + D WG LA+ A++ I+ A
Sbjct: 499 NSS-----EPWVWAQPVTTGKGQDHSPFWGFYFLL--LAVQAMITVIIVFA 542
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 216 bits (551), Expect = 4e-56
Identities = 148/444 (33%), Positives = 213/444 (47%), Gaps = 26/444 (5%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP C C +V C+ + VP +P ++ + T T L F + L +
Sbjct: 22 CPMGCDCF-VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVF 80
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
+L + P AF GL LE L ++ + L +
Sbjct: 81 LNTQLCQFRPDAFG------------------------GLPRLEDLEVTGSSFLNLSTNI 116
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
FS ++L +L L+ N LE +P+G F HL L L+L N L + R+FQ L +L+ L L
Sbjct: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNL 176
Query: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
+N L +P F L +LQ L L N + L G+F +LQ L+L +N+IS+LPP +
Sbjct: 177 AQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV 236
Query: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
F QL L RL L N++ L L IF + NL L L N + LP +F++ L L L
Sbjct: 237 FSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSL 296
Query: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
+ NQ+ ++ G F L+ LR L L NA+ L +FR L L + L +N L L +
Sbjct: 297 THNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
Query: 385 FANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPR 444
F N++ L + L NQL LP GIFD L L L+ NPW+CD + L NWL R
Sbjct: 357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDR 416
Query: 445 LGTDTVPVCFSPANVRGQSLIIIN 468
L + C PA ++GQ + +N
Sbjct: 417 L-LNIQTYCAGPAYLKGQVVPALN 439
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 192 bits (489), Expect = 5e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Query: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Query: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 341
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 342 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 429
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 580
Query: 430 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 464
+ LR++ L N PR G D P C SP V G L
Sbjct: 581 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 632
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 25 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
Query: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
Query: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
Query: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 438
Query: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 434
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 439 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 498
Query: 435 RNWLLLNQPRL 445
+LLL++ RL
Sbjct: 499 -EYLLLSRNRL 508
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 192 bits (489), Expect = 5e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Query: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Query: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 341
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 342 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 429
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 542
Query: 430 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 464
+ LR++ L N PR G D P C SP V G L
Sbjct: 543 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 25 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
Query: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
Query: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
Query: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
Query: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 434
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 460
Query: 435 RNWLLLNQPRL 445
+LLL++ RL
Sbjct: 461 -EYLLLSRNRL 470
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 183 bits (464), Expect = 4e-46
Identities = 134/423 (31%), Positives = 207/423 (48%), Gaps = 13/423 (3%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP++CTCS AS V+C G + AVP +P NA L + +IT + + F + L L +
Sbjct: 34 CPTKCTCSAAS-VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHL 92
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
E N++S I GAF++L L L L NKLQVLP LFQ L L LS NQ+ I
Sbjct: 93 EDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 152
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
F +++K LQL NH+ I DGAF L L L L N+++ I F H+ ++ LRL
Sbjct: 153 FRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRL 212
Query: 205 YENRL-TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL----QRLYLSNNHISQ 259
+ N L D + + + Q L + N+ ++ Y+ S+
Sbjct: 213 HSNHLYCDCHLAWLSDWLRQRRTV---GQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSE 269
Query: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR----ELWLYDNHISSLPDNVFSN 315
P + + T N + G+ NL E+ L N I ++P F+
Sbjct: 270 PPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329
Query: 316 LRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN 375
++L+ + +S+NQIS I+P AF GL L L L+ N + ++ +F L +LQ + L N
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
Query: 376 RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLR 435
++ L N F ++ L + L +N+L+ + G+F L + L L NP+ CD + L
Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLA 449
Query: 436 NWL 438
++L
Sbjct: 450 DYL 452
Score = 140 bits (354), Expect = 2e-33
Identities = 123/449 (27%), Positives = 192/449 (42%), Gaps = 85/449 (18%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CPS CTCS + V+C G ++ +P LP ++ +R+
Sbjct: 280 CPSPCTCSN-NIVDCRGKGLMEIPANLP------------------------EGIVEIRL 314
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
E+N + I GAF L+ + ++ N++ + FQGL S
Sbjct: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKS------------------ 356
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
L L L+GN + I G FD LV L L L N + + FQ L NL +L L
Sbjct: 357 ------LTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSL 410
Query: 205 YENRLTDIPMGTFDGLVNLQELALQQNQI-----------------------GLLSPGLF 241
Y+N+L I G F L ++Q L L QN SP
Sbjct: 411 YDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRL 470
Query: 242 HNNHNLQ------RLYLSNNHISQLPPSIFMQL--PQLNRL--TLFGNSLKELSLGIFGP 291
N Q R S ++ S+ FM L P+ R T+ S ++L + I
Sbjct: 471 ANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKL-VRIPSH 529
Query: 292 MPN-LRELWLYDNHISSLP-DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 349
+P + +L L DN +S L +F L L+ + LS N+I + GAF+G ++EL L
Sbjct: 530 LPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLT 589
Query: 350 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF 409
N L+ + G VFR L+ L+ + L++N + + + FA ++ + + L +N++ + G F
Sbjct: 590 GNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAF 649
Query: 410 DHLGKLCELRLYDNPWRCDSDILPLRNWL 438
L L + L NP+ C+ + L WL
Sbjct: 650 TTLVSLSTINLLSNPFNCNCHLAWLGKWL 678
Score = 115 bits (289), Expect = 8e-26
Identities = 104/381 (27%), Positives = 165/381 (43%), Gaps = 78/381 (20%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP +C C + V+C+ ++V +P+ LP ++T+L R+
Sbjct: 505 CPEKCRCE-GTIVDCSNQKLVRIPSHLP----------EYVTDL--------------RL 539
Query: 85 EKNELSRI-TPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
NE+S + G F+ L +LR ++L+NNK++ + G F G S++ L+L+ NQL +
Sbjct: 540 NDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGR 599
Query: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
F S LK L L N + + + F L + L+L N +T I+P F L +L +
Sbjct: 600 VFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTIN 659
Query: 204 LYEN---------------RLTDIPMGT-------FDGLVNLQELALQQ----------- 230
L N R I G F + +Q++A+Q
Sbjct: 660 LLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSC 719
Query: 231 -------NQIGLLSPGLFHNNHNLQ-----------RLYLSNNHISQLPPSIFMQLPQLN 272
Q + + +N L+ LYL NH++ +P + L L
Sbjct: 720 QLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPREL-SALRHLT 778
Query: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
+ L NS+ L+ F M +L L L N + +P + F+ LR L+VL L N IS +
Sbjct: 779 LIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSV 838
Query: 333 SPGAFNGLTELRELSLHTNAL 353
G+FN LT L L+L TN L
Sbjct: 839 PEGSFNDLTSLSHLALGTNPL 859
Score = 94.4 bits (233), Expect = 3e-19
Identities = 54/189 (28%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
RL L N++ ++ F + NLR L L DN +S + F +L+QL+ L L++N++ +
Sbjct: 65 RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
Query: 333 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 392
F +L L L N +Q + FR + +++N+ L NN + + F + L
Sbjct: 125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLE 184
Query: 393 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 452
+ L NN + + + F+H+ K+ LRL+ N CD + L +WL + R +
Sbjct: 185 ILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWL---RQRRTVGQFTL 241
Query: 453 CFSPANVRG 461
C +P ++RG
Sbjct: 242 CMAPVHLRG 250
Score = 71.6 bits (174), Expect = 2e-12
Identities = 121/555 (21%), Positives = 203/555 (36%), Gaps = 152/555 (27%)
Query: 41 GARIVAVPTPLPWNAMSLQILNTHITELN---ESPFLNISALIALRIEKNELSRITPGAF 97
G +I + L +SLQ+L + ++N + F ++ L L + N+L I+ G F
Sbjct: 364 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLF 423
Query: 98 RNLGSLRYLSLANNK-------------LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
L S++ L LA N LQ PI G L++ ++ QI+
Sbjct: 424 APLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET-SGARCSSPRRLANKRISQIKSKK 482
Query: 145 FS--------------------------------QCSNLKELQLHGNHLEYIPDGAFDHL 172
F CSN K +++ + EY+ D
Sbjct: 483 FRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD------ 536
Query: 173 VGLTKLNLGKNSLTHISPR-VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 231
L L N ++ + +F+ L NL+ + L N++ ++ G FDG ++QEL L N
Sbjct: 537 -----LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 591
Query: 232 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 291
Q+ + +F L+ L L +N I + F L + L+L+ N + ++ G F
Sbjct: 592 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 651
Query: 292 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 351
+ +L + L N P N +L L + R +S +P L+E+ +
Sbjct: 652 LVSLSTINLLSN-----PFNCNCHLAWLGKWLRKRRIVSG-NPRCQKPFF-LKEIPIQDV 704
Query: 352 ALQDL--DGN-------------------------------------------------- 359
A+QD DGN
Sbjct: 705 AIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHL 764
Query: 360 --VFRMLANLQNIS---LQNNRLRQLPGNIFANV---------------------NGLMA 393
V R L+ L++++ L NN + L F+N+ NGL +
Sbjct: 765 TAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRS 824
Query: 394 IQ---LQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 450
++ L N + ++P G F+ L L L L NP CD + L W+ G +
Sbjct: 825 LRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPG---I 881
Query: 451 PVCFSPANVRGQSLI 465
C SP + + L+
Sbjct: 882 ARCSSPEPMADRLLL 896
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 181 bits (458), Expect = 2e-45
Identities = 135/435 (31%), Positives = 215/435 (49%), Gaps = 22/435 (5%)
Query: 20 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
+A CP++C+CS S V+C G + +VP +P N L + +IT + ++ F + L
Sbjct: 23 VAPQACPAQCSCS-GSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHL 81
Query: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
L++ +N++S I GAF++L L L L N LQ+ P LF G L L LS NQ+
Sbjct: 82 RVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141
Query: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
I F ++K LQL N + I DGAF L L L L N++T +S F H+ L
Sbjct: 142 IPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
Query: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP--GLFH-NNHNL----QRLYL 252
+ RL+ N L L L + Q+ ++GL + G H HN+ +R ++
Sbjct: 202 RTFRLHSNNLY-----CDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFV 256
Query: 253 SNNHISQLPPSI-FMQLPQL-----NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 306
+ H S + PS + P N + G L E+ + + E+ L N I
Sbjct: 257 CSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL---PETITEIRLEQNTIK 313
Query: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
+P FS ++L+ + LS NQIS ++P AF GL L L L+ N + +L ++F L +
Sbjct: 314 VIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFS 373
Query: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
LQ + L N++ L + F +++ L + L +N+L+ + G F L + + L NP+
Sbjct: 374 LQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFI 433
Query: 427 CDSDILPLRNWLLLN 441
CD + L ++L N
Sbjct: 434 CDCHLKWLADYLHTN 448
Score = 140 bits (353), Expect = 3e-33
Identities = 114/421 (27%), Positives = 193/421 (45%), Gaps = 21/421 (4%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP+ CTCS + V+C G + +PT LP +++ I + F L + +
Sbjct: 273 CPAACTCSN-NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
N++S + P AF+ L SL L L NK+ LP LF+GL SL+ LLL++N++ ++
Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
F NL L L+ N L+ I G F L + ++L +N L+
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCH-----------LKW 440
Query: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL-SNNHISQLPPS 263
+ L P+ T G L +IG + F + Q + ++ S+L
Sbjct: 441 LADYLHTNPIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGD 499
Query: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPN-----LRELWLYDNHISSLP-DNVFSNLR 317
F L + G ++ + S +P EL L +N + L +F L
Sbjct: 500 CFADLACPEKCRCEGTTV-DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLP 558
Query: 318 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
QL+ + S N+I+ I GAF G + + E+ L +N L+++ +F+ L +L+ + L++NR+
Sbjct: 559 QLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRI 618
Query: 378 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW 437
+ + F ++ + + L +NQ+ + G FD L L L L NP+ C+ + L W
Sbjct: 619 TCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEW 678
Query: 438 L 438
L
Sbjct: 679 L 679
Score = 111 bits (278), Expect = 2e-24
Identities = 107/379 (28%), Positives = 174/379 (45%), Gaps = 49/379 (12%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP-FLNISALIALR 83
CP +C C + V+C+ ++ +P +P L++ N T L + F + L +
Sbjct: 506 CPEKCRCE-GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKIN 564
Query: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
N+++ I GAF + + L +N+L+ + +F+GL+SL++L+L SN++ +
Sbjct: 565 FSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624
Query: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS------LTHISPRVFQH-- 195
F S+++ L L+ N + + GAFD L L+ LNL N L + + +
Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRI 684
Query: 196 -LGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ---------NQIGLLSPGLFHNNH 245
GN + + Y L +IP +Q++A+Q N LS
Sbjct: 685 VTGNPRCQKPYF--LKEIP---------IQDVAIQDFTCDDGNDDNSCSPLSRCPTECTC 733
Query: 246 NLQRLYLSNNHISQLPPSIFMQLPQL----NRLTLFGNSLKELSLGIFGPMPNLRELWLY 301
+ SN + LP I + +L N+ TL KELS N + L L
Sbjct: 734 LDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP---KELS--------NYKHLTLI 782
Query: 302 D---NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDG 358
D N IS+L + FSN+ QL LILS N++ I P F+GL LR LSLH N + +
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 359 NVFRMLANLQNISLQNNRL 377
F L+ L ++++ N L
Sbjct: 843 GAFNDLSALSHLAIGANPL 861
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 179 bits (455), Expect = 5e-45
Identities = 139/474 (29%), Positives = 236/474 (49%), Gaps = 24/474 (5%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP+ C C ++C+ R+ +P PLP L + + ++ + S ++ +L +++
Sbjct: 47 CPTTCRCL-GDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
Query: 85 EKNELSRITPGAFRNLG----SLRYLSLANNKL-QVLPIGLFQGLDSLESLLLSSNQLLQ 139
NEL I NLG ++ LSLA N++ ++LP L + SLE+L LSSN + +
Sbjct: 106 NNNELETIP-----NLGPVSANITLLSLAGNRIVEILPEHLKE-FQSLETLDLSSNNISE 159
Query: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LTKLNLGKNSLTHISPRVFQHLGN 198
+Q A LK L L+ N + + G FD+L L L L +N ++ I P++F+ L
Sbjct: 160 LQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 216
Query: 199 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 258
LQ L L N++ ++ TF GL L+ L +Q+N + L G F N++ L L +N+++
Sbjct: 217 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276
Query: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
++ L L L L N++ +S + L EL L NH+S L D+ F L
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQDLDGNVFRMLANLQNISLQN 374
L L + N++S+I+ AF GL+ L+ L L N ++D++G F L L+ + LQ
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDKLRRLILQG 395
Query: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 434
NR+R + F ++ L + L +N + +L F + KL +L L + CD + L
Sbjct: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
Query: 435 RNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAV-PSVHVPEVPSYPET 487
W+ N + + C P ++G+S+ ++ + V P++ PET
Sbjct: 456 PQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPET 507
Score = 119 bits (298), Expect = 8e-27
Identities = 100/335 (29%), Positives = 161/335 (48%), Gaps = 12/335 (3%)
Query: 91 RITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSN 150
R P R LG L L + +L LP L + L+ LS N+L I+ + S +
Sbjct: 45 RPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLD---LSHNRLSFIKASSMSHLQS 99
Query: 151 LKELQLHGNHLEYIPD-GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
L+E++L+ N LE IP+ G +T L+L N + I P + +L+ L L N +
Sbjct: 100 LREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
Query: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN-LQRLYLSNNHISQLPPSIFMQL 268
+++ T + L+ L L N++ + PG F N N L L L+ N IS +PP +F +L
Sbjct: 158 SELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KL 214
Query: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
PQL L L N +K + F + L+ L + N ++ L D F L +++L L N
Sbjct: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
Query: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
++ I+ G GL L+EL L NA+ + + + L + L N L +L + F +
Sbjct: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL 334
Query: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
+ L + + NN++ + F L L L L +N
Sbjct: 335 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 178 bits (452), Expect = 1e-44
Identities = 139/455 (30%), Positives = 221/455 (48%), Gaps = 25/455 (5%)
Query: 2 PLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQIL 61
P++ L LL+ AW G + CP+ CTC+ + V+C G + A+P +P N L++
Sbjct: 13 PVRPELWLLLWAAAWRLGAS--ACPALCTCT-GTTVDCHGTGLQAIPKNIPRNTERLELN 69
Query: 62 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLF 121
+IT ++++ F + L L++ +N++ + GAF ++ L L L N+L +LP LF
Sbjct: 70 GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLF 129
Query: 122 QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLG 181
Q +L L LS N + I F ++LK LQL N + I +GAF L GL L L
Sbjct: 130 QNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLN 189
Query: 182 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLF 241
N++T I F H+ L+ RL+ N L L L + Q+ IGL +
Sbjct: 190 NNNITTIPVSSFNHMPKLRTFRLHSNHLF-----CDCHLAWLSQWLRQRPTIGLFTQ--C 242
Query: 242 HNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL---SLGIF--------- 289
+L+ L ++ S+ S + ++ TL S + S GI
Sbjct: 243 SGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTA 302
Query: 290 --GPMP-NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 346
+P + E+ L N I S+P FS R+L+ + LS NQI+ I+P AF GL L L
Sbjct: 303 IPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSL 362
Query: 347 SLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL 406
L+ N + DL VF L LQ + L N++ + + F ++ L + L +N++++L
Sbjct: 363 VLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAK 422
Query: 407 GIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 441
G F L + L L NP+ CD ++ L ++L N
Sbjct: 423 GTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTN 457
Score = 147 bits (371), Expect = 3e-35
Identities = 125/446 (28%), Positives = 201/446 (45%), Gaps = 22/446 (4%)
Query: 20 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
L+ CP+ CTCS V+C G + A+P LP +++ I + F L
Sbjct: 277 LSSGSCPAMCTCSNGI-VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
Query: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
+ + N+++ I P AF+ L SL L L NK+ LP G+F GL +L+ LLL++N++
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
I+P F NL L L+ N ++ + G F L + L+L +N F NL
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP--------FICDCNL 447
Query: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
+ L + L P+ T G L +IG + F + ++ ++ Q
Sbjct: 448 KWLADF---LRTNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDYQ 502
Query: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL----RELWLYDNHISSLP-DNVFS 314
L + ++ N ++ SL + + EL L +N IS L +F
Sbjct: 503 LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFK 562
Query: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
L L+ + LS N++S I GAF G + EL L N L+ + +FR L L+ + L+N
Sbjct: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRN 622
Query: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 434
NR+ + + F + + + L +NQ+ + G FD L L L L NP+ C+ + L
Sbjct: 623 NRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWL 682
Query: 435 RNWLLLNQPRLGTDTVPVCFSPANVR 460
WL + G P C +P +R
Sbjct: 683 GGWLRKRKIVTGN---PRCQNPDFLR 705
Score = 129 bits (324), Expect = 7e-30
Identities = 108/363 (29%), Positives = 169/363 (46%), Gaps = 17/363 (4%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP-FLNISALIALR 83
CP +C C A+ VEC+ ++ +P +P + L++ N I+ L + F ++ L +
Sbjct: 513 CPHKCRCE-ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571
Query: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
+ N++S I GAF S+ L L N+L+ + G+F+GLD L +L+L +N++ I
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631
Query: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
F+ N++ L L+ N + + GAFD L L+ LNL N + LG R
Sbjct: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAW--LGGWLRKR 689
Query: 204 LYENRLTDIPMGTFDGLVNLQELALQ--QNQIGLLSPGLFHNNHNLQR-------LYLSN 254
F + LQ++A + + G G Q + SN
Sbjct: 690 KIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN 749
Query: 255 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 314
H+ LP I + L L GN L G L+ + L +N ISSL ++ F+
Sbjct: 750 KHLRALPKGI---PKNVTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFT 805
Query: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
N+ QL LILS N + I P AF GL LR LSLH N + L +F + +L ++++
Sbjct: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
Query: 375 NRL 377
N L
Sbjct: 866 NPL 868
Score = 99.8 bits (247), Expect = 6e-21
Identities = 59/189 (31%), Positives = 95/189 (50%), Gaps = 3/189 (1%)
Query: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
RL L GN++ + F + LR L L +N I ++ F ++++L+ L L+RNQ+ +
Sbjct: 65 RLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML 124
Query: 333 SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM 392
F L L L NA+Q + FR +L+N+ L N++ + F + GL
Sbjct: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
Query: 393 AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPV 452
+ L NN + +P+ F+H+ KL RL+ N CD + L W L +P +G T
Sbjct: 185 VLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW-LRQRPTIGLFT--Q 241
Query: 453 CFSPANVRG 461
C PA++RG
Sbjct: 242 CSGPASLRG 250
Score = 66.2 bits (160), Expect = 8e-11
Identities = 47/172 (27%), Positives = 69/172 (40%), Gaps = 26/172 (15%)
Query: 14 QAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPF 73
Q G L CP EC C + V C+ + A+P +P N L + T
Sbjct: 723 QEEGGCLPRPQCPQECACLD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFT------- 774
Query: 74 LNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS 133
+ PG L+ + L+NNK+ L F + L +L+LS
Sbjct: 775 ------------------LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILS 816
Query: 134 SNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
N L I P F +L+ L LHGN + + +G F + L+ L +G N L
Sbjct: 817 YNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 174 bits (441), Expect = 2e-43
Identities = 125/429 (29%), Positives = 202/429 (47%), Gaps = 29/429 (6%)
Query: 18 AGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 77
+G A C + C+C +V+C+G + AVP L +L I +IT+L E F N
Sbjct: 22 SGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFP 81
Query: 78 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 137
L L++ N+LS I P A L L+ L+L NN+L+ +P +GL +L+SL L +N +
Sbjct: 82 FLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
Query: 138 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLG 197
+ F L+ L L N L +P +L L L L N ++ I F +L
Sbjct: 142 TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLS 201
Query: 198 NLQVLRLYENRLTDIPMGTFDGLVNLQ-----------------------ELALQQNQIG 234
+L VL L+ N++ + FDGL NL+ EL N I
Sbjct: 202 SLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSIS 261
Query: 235 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 294
++ G F N L+ ++L +N +S + S F L L+ L + G S+ + + G + +
Sbjct: 262 VIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV-H 320
Query: 295 LRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQ 354
L L L ISS+P+N+ + L+ L LS N I + +FNG L E+SL N +
Sbjct: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIY 378
Query: 355 DLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK 414
+ F+ L +L+ + L N + ++ FA + + + + N+L + P + L
Sbjct: 379 QIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT---EGLNG 435
Query: 415 LCELRLYDN 423
L +L+L N
Sbjct: 436 LNQLKLVGN 444
Score = 112 bits (279), Expect = 1e-24
Identities = 74/225 (32%), Positives = 105/225 (46%), Gaps = 1/225 (0%)
Query: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Q L + N +T +P F L+EL L N + + P L+ L L NN +
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Query: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
+P L L L L N + + F + LR LWL DN ++ +P + SNL L
Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
Query: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Q L L+ N+IS I AF L+ L L LH N ++ L + F L NL+ + L N L +
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
Query: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424
P I A + L + +N + +P G FD L + LYDNP
Sbjct: 240 FPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283
Score = 75.1 bits (183), Expect = 2e-13
Identities = 52/179 (29%), Positives = 83/179 (46%), Gaps = 24/179 (13%)
Query: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
Q L +S N+I+QLP F P L L L GN L S
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDL------------------------SF 95
Query: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 367
+ S L++L+VL L NQ+ + A GL+ L+ L L N + + + F L L
Sbjct: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
Query: 368 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
+++ L +N L ++P + +N+ L A+ L N++ ++P F +L L L L++N R
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIR 214
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 170 bits (431), Expect = 3e-42
Identities = 129/427 (30%), Positives = 204/427 (47%), Gaps = 30/427 (7%)
Query: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ----VECTGARIVAVPTPLPWNAMSLQILN 62
L L G + +G+ GCP+ C C + V+C+ + +P+ L L +
Sbjct: 16 LQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSM 75
Query: 63 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 122
+I++L +P ++ L LR+ N L+ I GAF L SL+ L L NN+L+ +P Q
Sbjct: 76 NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
Query: 123 GLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK 182
L SL+SL L +N + + P+ FS +L+ L L N L IP AF L L + L
Sbjct: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLAL 195
Query: 183 NSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDG----------------------- 219
N + HI F +L +L VL L+ NR+ + FDG
Sbjct: 196 NKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRT 255
Query: 220 LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGN 279
L NL+EL N I + F N +L ++ +N I + S F LP+L LTL G
Sbjct: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
Query: 280 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339
S + G NL L L ISSLP V + L LQVL LS N + + +F+
Sbjct: 316 SQITEFPDLTG-TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
Query: 340 LTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 399
+L+++ L N + ++ + F+ L +L++++L N++ + N F+ + L+ + L +N
Sbjct: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
Query: 400 QLENLPL 406
L + P+
Sbjct: 433 LLSSFPI 439
Score = 131 bits (330), Expect = 1e-30
Identities = 85/243 (34%), Positives = 121/243 (49%), Gaps = 1/243 (0%)
Query: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
L+L N+++ + P L L+ LRL N LT IP G F GL +L+ L LQ NQ+ +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
N +LQ L L NHIS +PPS F L L L L N+L E+ + F + L+
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
+ L N I +PD F NL L VL L N+I + F+GL L L L+ N L +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 358 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
R L+NL+ + +N +R +P F L+ I +N ++ + F HL +L
Sbjct: 251 -TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 418 LRL 420
L L
Sbjct: 310 LTL 312
Score = 126 bits (316), Expect = 6e-29
Identities = 103/293 (35%), Positives = 145/293 (49%), Gaps = 8/293 (2%)
Query: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
+TE+ F ++SAL A+ + N++ I AF NL SL L L NN++ L F GL
Sbjct: 174 LTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGL 233
Query: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
SLE+L L+ N L + P SNLKEL H N++ IP+ AF L ++ N
Sbjct: 234 HSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292
Query: 185 LTHISPRVFQHLGNLQVLRLY-ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
+ + FQHL L+ L L +++T+ P T G NL+ L L QI L + +
Sbjct: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPDLT--GTANLESLTLTGAQISSLPQTVCNQ 350
Query: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
NLQ L LS N + LP F +L ++ L N + E+ + F + +LR L L N
Sbjct: 351 LPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
Query: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
I+ + N FS L L L LS N +S +GLT L+ H ALQ L
Sbjct: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNH--ALQSL 459
Score = 108 bits (269), Expect = 2e-23
Identities = 67/175 (38%), Positives = 96/175 (54%), Gaps = 1/175 (0%)
Query: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
L LS N+ISQL P+ L L L L GN+L + G F + +L+ L L +N + +P
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
NLR LQ L L N IS++ P F+GL LR L L NAL ++ FR L+ LQ
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL-YDN 423
++L N++ +P F N++ L+ + L NN++ +L FD L L L L Y+N
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
Score = 64.3 bits (155), Expect = 3e-10
Identities = 65/247 (26%), Positives = 95/247 (38%), Gaps = 43/247 (17%)
Query: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
N L + +I + E F+ +LI + N + + AF++L LR L+L N
Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL-NGAS 316
Query: 114 QVLPIGLFQGLDSLESLLLSS-----------NQLLQIQPAH-----------FSQCSNL 151
Q+ G +LESL L+ NQL +Q FS C L
Sbjct: 317 QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 376
Query: 152 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD 211
+++ L N + I F L+ L LNL N + I P F L +L L L N L+
Sbjct: 377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 436
Query: 212 IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL 271
P+ GL +L+ NH LQ L S N P +++P
Sbjct: 437 FPITGLHGLTHLK----------------LTGNHALQSLISSEN----FPELKVIEMPYA 476
Query: 272 NRLTLFG 278
+ FG
Sbjct: 477 YQCCAFG 483
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 165 bits (418), Expect = 9e-41
Identities = 125/373 (33%), Positives = 171/373 (45%), Gaps = 27/373 (7%)
Query: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECT--GARIVAVPTPLPWNAMSLQILNTH 64
LL++ GC A LA CP C C + CT G R+V + LP
Sbjct: 10 LLVVCGCLALPP-LAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLP------------ 56
Query: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
SP ++ + N ++ IT F LG LR L L N+++ L F+ L
Sbjct: 57 ------SPH----DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKL 106
Query: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
LE L L +N L + P + L+ L +GN + + G+F+ L L KL L N+
Sbjct: 107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNA 166
Query: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFH 242
L + VF LGNL L L NR+ + F L L+ L L N++ L F
Sbjct: 167 LGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFA 226
Query: 243 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD 302
+L L LS N++ L P IF LP+L L+L GN L L+ F + LREL L
Sbjct: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
Query: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
N +S LP + L L+ L LS N++S + P F L LRELSL NAL L G++F
Sbjct: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
Query: 363 MLANLQNISLQNN 375
L + L N
Sbjct: 347 ASPALYRLDLDGN 359
Score = 143 bits (361), Expect = 4e-34
Identities = 116/368 (31%), Positives = 172/368 (46%), Gaps = 10/368 (2%)
Query: 104 RYLSLANNKLQVLPIGLFQGLDSLESLL---LSSNQLLQIQPAHFSQCSNLKELQLHGNH 160
++L N L+V+P L S +L L N + I F + L+ L L N
Sbjct: 37 QHLLCTNRGLRVVP--KTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQ 94
Query: 161 LEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGL 220
+ + F+ L L +L LG N L ++P L L++L N ++ + G+F+GL
Sbjct: 95 IRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGL 154
Query: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280
+L +L L N +G L +F NL L+L +N I L + F QL +L L L N
Sbjct: 155 ESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANE 214
Query: 281 LKEL--SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 338
L+ F P+ +L L L N++ L +F +L +L +L L NQ++ ++P AF
Sbjct: 215 LQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFW 274
Query: 339 GLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN 398
GL LREL L N L L + L +L+ + L N L L F ++ L + L+N
Sbjct: 275 GLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334
Query: 399 NQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL--LLNQPRLGTDTVPVCFSP 456
N L L IF L L L N W CD + L+ W+ +Q RL T V C P
Sbjct: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQ-CRHP 393
Query: 457 ANVRGQSL 464
+RG+ L
Sbjct: 394 PALRGKYL 401
Score = 70.1 bits (170), Expect = 5e-12
Identities = 47/136 (34%), Positives = 68/136 (50%), Gaps = 1/136 (0%)
Query: 52 PWNAMSLQILNTH-ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110
P ++S IL+ + + L F ++ L L + N+L+ + P AF L +LR L L
Sbjct: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
Query: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170
N+L LP L + L SLE+L LS N+L + PA F L+EL L N L + F
Sbjct: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
Query: 171 HLVGLTKLNLGKNSLT 186
L +L+L N T
Sbjct: 347 ASPALYRLDLDGNGWT 362
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 165 bits (418), Expect = 9e-41
Identities = 124/403 (30%), Positives = 187/403 (46%), Gaps = 9/403 (2%)
Query: 25 CPSECTCSRAS---QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIA 81
CP+ C C +C+ + AVP L L + ++TEL F ++ L
Sbjct: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
Query: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141
LR+ N LS I AF L SL+ L L NN+L +P L SL+SL L +N + +
Sbjct: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
Query: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201
F S+L+ L L N L IP A ++L L + L N ++HI FQ+L +L V
Sbjct: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
Query: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
L L+ NR+ + +F+GL NL+ L L N++ P LQ L NN+I +P
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIP 273
Query: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDNVFSNLRQLQ 320
FM P L + + N ++ + F +P L L L I PD L+
Sbjct: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLE 331
Query: 321 VLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 380
+L L+R I + G L LR L L N +++L L+ I LQ+NR+ ++
Sbjct: 332 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEI 389
Query: 381 PGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
+ F+ ++ L A+ L N + ++ F L L +L L DN
Sbjct: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 432
Score = 119 bits (298), Expect = 8e-27
Identities = 81/247 (32%), Positives = 116/247 (46%), Gaps = 25/247 (10%)
Query: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
L+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQ-------- 122
Query: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
NN + +P +LP L L L N + + F + +LR
Sbjct: 123 ----------------NNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166
Query: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
LWL DN ++ +P +NL LQ + L+ N+IS I AF LT L L LH N +Q L
Sbjct: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
Query: 358 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
+ F L NL+ + L N+L++ P I + L + NN ++ +P F L
Sbjct: 227 THSFEGLHNLETLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 285
Query: 418 LRLYDNP 424
+ YDNP
Sbjct: 286 IHFYDNP 292
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 5/132 (3%)
Query: 102 SLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL 161
SL L+L +++LP G+ Q L L L LS NQ+ ++ H +C L+E+ L N +
Sbjct: 329 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH--RCQKLEEIGLQHNRI 386
Query: 162 EYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLV 221
I F L L L+L N++ I P F L +L L L +N+LT +P+ GL+
Sbjct: 387 WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 446
Query: 222 NLQ---ELALQQ 230
+L+ LAL Q
Sbjct: 447 HLKLKGNLALSQ 458
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 161 bits (408), Expect = 1e-39
Identities = 98/331 (29%), Positives = 167/331 (50%), Gaps = 1/331 (0%)
Query: 24 GCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 82
GCP+ C CS ++ V C R++A+P +P L + + +N F++ L +
Sbjct: 27 GCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEI 86
Query: 83 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
+ N ++ + PGAF NL +LR L L N+L+++P+G+F GL +L L +S N+++ +
Sbjct: 87 DLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLD 146
Query: 143 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 202
F NLK L++ N L YI AF L+ L +L L K +LT + HL +L L
Sbjct: 147 YMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
Query: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
L + ++P+ F L +L+ L + + + P NL L ++N ++S +P
Sbjct: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPF 266
Query: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322
F L L L L N + + G+F + L+EL + + ++ + F LR L+VL
Sbjct: 267 LAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVL 326
Query: 323 ILSRNQISFISPGAFNGLTELRELSLHTNAL 353
+S+N + + F+ L LS++ N L
Sbjct: 327 NVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 83.6 bits (205), Expect = 5e-16
Identities = 61/205 (29%), Positives = 101/205 (49%)
Query: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
N SL++ + + ++ F + +L L +EK L+ + A +L SL L L + +
Sbjct: 154 NLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNI 213
Query: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
+P+ F+ L L+ L + LL + PA+ NL L + +L +P AF HLV
Sbjct: 214 NNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLV 273
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
LT LNL N ++ I +F L LQ L + +L I +F GL L+ L + QN +
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHIS 258
L +F + L+ L ++NN ++
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPLA 358
Score = 82.8 bits (203), Expect = 8e-16
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 29/245 (11%)
Query: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
+ RL IP G + + L L +N++ ++P F + L+ + LS+N I+ + P
Sbjct: 44 HRRRLIAIPEGI---PIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGA 100
Query: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
F L L L L GN LK + LG+F + NL +L + +N I L D +F +L L+ L +
Sbjct: 101 FNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV 160
Query: 325 SRNQISFISPGAFNGLTELRELSLH--------TNALQDLDGNV---------------- 360
N + +IS AF+GL L +L+L T AL L +
Sbjct: 161 GDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYA 220
Query: 361 FRMLANLQNISLQN-NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELR 419
F+ L +L+++ + L +P N +N L ++ + N L +P F HL L L
Sbjct: 221 FKRLFHLKHLEIDYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279
Query: 420 LYDNP 424
L NP
Sbjct: 280 LSYNP 284
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 160 bits (406), Expect = 2e-39
Identities = 111/366 (30%), Positives = 185/366 (50%), Gaps = 6/366 (1%)
Query: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
+S L L+ N + I + + +L L L +++ Y+ AF L L L L N
Sbjct: 60 ESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF 119
Query: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 244
+ + P +F+ L NL+ L L N+++ +P G F+ LV++Q L LQ+N++ +L G F
Sbjct: 120 IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGM 179
Query: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
L+ L LSNN+I ++ S F L L L L N+L ++ F + +LR L L N
Sbjct: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239
Query: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
I ++ F L L+ L+L ++I ++ F+G+ L+ L L N L++L+ + F +L
Sbjct: 240 IEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLL 299
Query: 365 ANLQNISLQNNRLRQLPGNIFANVN-GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
NL + L NR+ + + F N+ L + L N L L + L L L+ N
Sbjct: 300 KNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Query: 424 PWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINV-NVAVPSVHVPEVP 482
PW C+ +L LR+WL + L C +P ++RG++L IN+ N S++V
Sbjct: 360 PWECNCKLLGLRDWLASSAITLNI----YCQNPPSMRGRALRYINITNCVTSSINVSRAW 415
Query: 483 SYPETP 488
+ ++P
Sbjct: 416 AVVKSP 421
Score = 160 bits (404), Expect = 4e-39
Identities = 103/329 (31%), Positives = 164/329 (49%), Gaps = 1/329 (0%)
Query: 24 GCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83
GC S C Q+ C + ++P P + + L + +I+ +NES + +L+AL
Sbjct: 31 GCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALY 90
Query: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
++ + + + P AF L L +L L NN ++ L G+F+GL +L +L L NQ+ +
Sbjct: 91 LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRG 150
Query: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
F+ +++ L L N L + G F +V L L+L N++ IS FQHL NL L
Sbjct: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
Query: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
L N LT +P F+ L +L+ L+L N I + P F NL+ L L N+ I +
Sbjct: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD 270
Query: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL-RQLQVL 322
F + L L L N L+ L+ F + NL L L N I S+ ++ F N+ L++L
Sbjct: 271 GFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKIL 330
Query: 323 ILSRNQISFISPGAFNGLTELRELSLHTN 351
LS N ++ + P L+ L L ++N
Sbjct: 331 NLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 159 bits (402), Expect = 7e-39
Identities = 128/437 (29%), Positives = 218/437 (49%), Gaps = 23/437 (5%)
Query: 62 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLG----SLRYLSLANNKL-QVL 116
+ ++ + S ++ +L +++ NEL I NLG ++ LSLA N++ ++L
Sbjct: 23 HNRLSFIKASSMSHLQSLREVKLNNNELETIP-----NLGPVSANITLLSLAGNRIVEIL 77
Query: 117 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-L 175
P L + SLE+L LSSN + ++Q A LK L L+ N + + G FD+L L
Sbjct: 78 PEHLKE-FQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTL 134
Query: 176 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 235
L L +N ++ I P++F+ L LQ L L N++ ++ TF GL L+ L +Q+N +
Sbjct: 135 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
Query: 236 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 295
L G F N++ L L +N+++++ L L L L N++ +S + L
Sbjct: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253
Query: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---- 351
EL L NH+S L D+ F L L L + N++S+I+ AF GL+ L+ L L N
Sbjct: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313
Query: 352 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 411
++D++G F L L+ + LQ NR+R + F ++ L + L +N + +L F
Sbjct: 314 TIEDMNG-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
Query: 412 LGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNV 471
+ KL +L L + CD + L W+ N + + C P ++G+S+ ++ +
Sbjct: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDG 430
Query: 472 AV-PSVHVPEVPSYPET 487
V P++ PET
Sbjct: 431 FVCDDFPKPQITVQPET 447
Score = 143 bits (361), Expect = 4e-34
Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 9/348 (2%)
Query: 36 QVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRIT 93
+V+ + +P P+ N L + I E+ +L L + N +S +
Sbjct: 42 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101
Query: 94 PGAFRNLGSLRYLSLANNKLQVLPIGLFQGL-DSLESLLLSSNQLLQIQPAHFSQCSNLK 152
AF L L+YL L +N++ + G F L ++L L L+ N++ I P F + L+
Sbjct: 102 T-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQ 158
Query: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
L+L+ N ++ + F L L L + +N +T + F L N+++L+L N LT+I
Sbjct: 159 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218
Query: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272
G GL+ LQEL L QN I +SP + L L L+ NH+S+L S F+ L LN
Sbjct: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278
Query: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPD--NVFSNLRQLQVLILSRNQI 329
L + N + ++ F + +L+ L L +N IS ++ D FS L +L+ LIL N+I
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
Query: 330 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
I+ AF GL L L L NA+ L GN F + LQ + L + L
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
Score = 140 bits (352), Expect = 4e-33
Identities = 112/381 (29%), Positives = 183/381 (48%), Gaps = 9/381 (2%)
Query: 27 SECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLN-ISALIAL-RI 84
S C S+ + + R+ + + SL+ + + EL P L +SA I L +
Sbjct: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
N + I P + SL L L++N + L F L L+ L L+SN++ ++P +
Sbjct: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGY 126
Query: 145 FSQCSN-LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
F +N L L+L+ N + IP F L L L L +N + ++ FQ LG L+ L+
Sbjct: 127 FDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 185
Query: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
+ N +T + G F GL N++ L L N + ++ G + LQ L+LS N I+++ P
Sbjct: 186 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 245
Query: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323
+ +L+ L L N L L F + L L + +N +S + D F L L+ L
Sbjct: 246 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 305
Query: 324 LSRNQISFISP---GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 380
L N+IS+ GAF+GL +LR L L N ++ + F L L+++ L +N + L
Sbjct: 306 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 365
Query: 381 PGNIFANVNGLMAIQLQNNQL 401
GN F+ + L + L + L
Sbjct: 366 QGNAFSQMKKLQQLHLNTSSL 386
Score = 116 bits (291), Expect = 5e-26
Identities = 88/294 (29%), Positives = 145/294 (49%), Gaps = 7/294 (2%)
Query: 132 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPD-GAFDHLVGLTKLNLGKNSLTHISP 190
LS N+L I+ + S +L+E++L+ N LE IP+ G +T L+L N + I P
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILP 78
Query: 191 RVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN-LQR 249
+ +L+ L L N ++++ T + L+ L L N++ + PG F N N L
Sbjct: 79 EHLKEFQSLETLDLSSNNISELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
Query: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
L L+ N IS +PP +F +LPQL L L N +K + F + L+ L + N ++ L
Sbjct: 137 LKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
D F L +++L L N ++ I+ G GL L+EL L NA+ + + + L
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
+ L N L +L + F ++ L + + NN++ + F L L L L +N
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 29.6 bits (65), Expect = 8.0
Identities = 12/43 (27%), Positives = 25/43 (58%)
Query: 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
+L ++ L +NRL + + +++ L ++L NN+LE +P
Sbjct: 12 LLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP 54
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 154 bits (388), Expect = 3e-37
Identities = 114/361 (31%), Positives = 172/361 (47%), Gaps = 6/361 (1%)
Query: 64 HITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
++TEL F ++ L LR+ N LS I AF L SL+ L L NN+L +P
Sbjct: 25 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 84
Query: 124 LDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183
L SL+SL L +N + + F S+L+ L L N L IP A ++L L + L N
Sbjct: 85 LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 144
Query: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
++HI FQ+L +L VL L+ NR+ + +F+GL NL+ L L N++ P
Sbjct: 145 RISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRT 203
Query: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD- 302
LQ L NN+I +P FM P L + + N ++ + F +P L L L
Sbjct: 204 LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 263
Query: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
I PD L++L L+R I + G L LR L L N +++L
Sbjct: 264 MDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LH 319
Query: 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 422
L+ I LQ+NR+ ++ + F+ ++ L A+ L N + ++ F L L +L L D
Sbjct: 320 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 379
Query: 423 N 423
N
Sbjct: 380 N 380
Score = 147 bits (372), Expect = 2e-35
Identities = 111/366 (30%), Positives = 176/366 (48%), Gaps = 7/366 (1%)
Query: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
L++ H++ + F + +L L ++ N+L I A L SL+ L L N + ++P
Sbjct: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
Query: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 177
F+GL SL L L N L +I + L+ + L N + +IPD AF +L L
Sbjct: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 162
Query: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
L+L N + H+ F+ L NL+ L L N+L + P+ L LQEL N I +
Sbjct: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIP 221
Query: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
F N LQ ++ +N I + S F LP+L+ L+L G ++ +L
Sbjct: 222 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-AMDIQEFPDLKGTTSLEI 280
Query: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
L L I LP + L +L+VL LS NQI + + + +L E+ L N + ++
Sbjct: 281 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIG 338
Query: 358 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
+ F L++LQ + L N +R + F+ ++ L+ + L +NQL LPL LG L
Sbjct: 339 ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA---GLGGLMH 395
Query: 418 LRLYDN 423
L+L N
Sbjct: 396 LKLKGN 401
Score = 126 bits (317), Expect = 5e-29
Identities = 85/242 (35%), Positives = 119/242 (49%), Gaps = 1/242 (0%)
Query: 179 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP 238
+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ NQ+G +
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 239 GLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 298
+LQ L L N IS +P F L L L L N+L E+ + +P L+ +
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 299 WLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDG 358
L N IS +PD F NL L VL L N+I + +F GL L L L+ N LQ+
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
Query: 359 NVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 418
+ R L LQ + NN ++ +P F L I +N ++ + F +L KL L
Sbjct: 200 AI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
Query: 419 RL 420
L
Sbjct: 259 SL 260
Score = 107 bits (268), Expect = 2e-23
Identities = 102/332 (30%), Positives = 148/332 (44%), Gaps = 10/332 (3%)
Query: 47 VPTPLPWNAMSLQILNTH---ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSL 103
+P W SLQ L I+ + E F +S+L L ++ N L+ I A NL +L
Sbjct: 77 IPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPAL 136
Query: 104 RYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEY 163
+ ++LA N++ +P FQ L SL L L +N++ + F NL+ L L+ N L+
Sbjct: 137 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 196
Query: 164 IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNL 223
P A L L +L N++ I + F LQ + Y+N + + F L L
Sbjct: 197 FP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKL 255
Query: 224 QELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKE 283
L+L P L +L+ L L+ I LP + QLP+L L L N ++E
Sbjct: 256 HTLSLNGAMDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE 314
Query: 284 LSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTEL 343
L L E+ L N I + + FS L LQ L LS N I I P AF+ L L
Sbjct: 315 LP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 372
Query: 344 RELSLHTNALQDLDGNVFRMLANLQNISLQNN 375
+L L N L L L L ++ L+ N
Sbjct: 373 VKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 152 bits (384), Expect = 8e-37
Identities = 135/493 (27%), Positives = 223/493 (45%), Gaps = 60/493 (12%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
C + CTC+ S ++C G + A+P LP S +L +
Sbjct: 41 CAAACTCAGDS-LDCGGRGLAALPGDLP------------------------SWTRSLNL 75
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
N+LS I P F +L +L+ + L NN+L +P L + SL L N++ ++ +
Sbjct: 76 SYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVP-SLGAASSHVVSLFLQHNKIRSVEGSQ 134
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLG-NLQVLR 203
+L+ L L N++ + + F H + +LNL N + + F L +L LR
Sbjct: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
Query: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
L +NR+T +P+ F L L +L L +N+I L+ F ++L+ L L N+IS+L
Sbjct: 195 LSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253
Query: 264 IFMQLPQLNRLTLFGNSLKELSLG-IFGP-----------------------MPNLRELW 299
F L +++ L L NSL E++ G ++G L EL
Sbjct: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
Query: 300 LYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQD 355
L N+++ L + + L L VL LS N IS I+ GAF GL LR L L N ++D
Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 356 LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 415
G F L +L ++L N+++ + F+ + GL + L N + ++ F + L
Sbjct: 374 TSG-AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNL 432
Query: 416 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS 475
EL + + + CD + L WL+ L C P +++GQS+ + V
Sbjct: 433 KELHISSDSFLCDCQLKWLPPWLIGRM--LQAFVTATCAHPESLKGQSIFSVPPESFVCD 490
Query: 476 VHV-PEVPSYPET 487
+ P++ + PET
Sbjct: 491 DFLKPQIITQPET 503
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 152 bits (383), Expect = 1e-36
Identities = 116/373 (31%), Positives = 178/373 (47%), Gaps = 30/373 (8%)
Query: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHI 65
LLL++G G+ GCP C CS + V C R VAVP +P L + I
Sbjct: 27 LLLVLGSVLSGSAT---GCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83
Query: 66 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
LN+ F + L L + +N +S + PGAF NL +LR L L +N+L+++P+G+F GL
Sbjct: 84 KTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLS 143
Query: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
+L L +S N+++ + F NLK L++ N L YI AF L L +L L K +L
Sbjct: 144 NLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 203
Query: 186 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ-NQIGLLSPGLFHNN 244
T I HL L VLRL + I +F L L+ L + + ++P +
Sbjct: 204 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY-G 262
Query: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
NL L +++ +++ +P L LR L L N
Sbjct: 263 LNLTSLSITHCNLTAVPYLAVRHLVY------------------------LRFLNLSYNP 298
Query: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
IS++ ++ L +LQ + L Q++ + P AF GL LR L++ N L L+ +VF +
Sbjct: 299 ISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSV 358
Query: 365 ANLQNISLQNNRL 377
NL+ + L +N L
Sbjct: 359 GNLETLILDSNPL 371
Score = 115 bits (287), Expect = 1e-25
Identities = 93/334 (27%), Positives = 151/334 (45%), Gaps = 29/334 (8%)
Query: 154 LQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 213
L L N ++ + F L +L L +N ++ + P F +L NL+ L L NRL IP
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
Query: 214 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNR 273
+G F GL NL +L + +N+I +L +F + +NL+ L + +N + + F L L +
Sbjct: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
Query: 274 LTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR-NQISFI 332
LTL +L + + L L L +I+++ D F L +L+VL +S + +
Sbjct: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTM 255
Query: 333 SPGAFNGLT-----------------------ELRELSLHTNALQDLDGNVFRMLANLQN 369
+P GL LR L+L N + ++G++ L LQ
Sbjct: 256 TPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQE 315
Query: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 429
I L +L + F +N L + + NQL L +F +G L L L NP CD
Sbjct: 316 IQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDC 375
Query: 430 DILPLRNWLLLNQPRLGTD-TVPVCFSPANVRGQ 462
+L W+ + RL + P C +P V+G+
Sbjct: 376 RLL----WVFRRRWRLNFNRQQPTCATPEFVQGK 405
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/154 (31%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 268 LPQLNRLTLFG-NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 326
+P RL G N +K L+ F P+L EL L +N +S++ F+NL L+ L L
Sbjct: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
Query: 327 NQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFA 386
N++ I G F GL+ L +L + N + L +F+ L NL+++ + +N L + F+
Sbjct: 129 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
Query: 387 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 420
+N L + L+ L ++P HL L LRL
Sbjct: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/229 (26%), Positives = 98/229 (42%), Gaps = 21/229 (9%)
Query: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
L L N I L F P L L L N + + G F + NLR L L N + +P
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
Query: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
VF+ L L L +S N+I + F L L+ L + N L + F L +L+
Sbjct: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
Query: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 429
++L+ L +P ++++GL+ ++L++ + + F L +L
Sbjct: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL-------------- 241
Query: 430 DILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHV 478
+L + +W P L T T P C N+ S+ N+ AVP + V
Sbjct: 242 KVLEISHW-----PYLDTMT-PNCLYGLNLTSLSITHCNL-TAVPYLAV 283
Score = 53.1 bits (126), Expect = 7e-07
Identities = 29/106 (27%), Positives = 55/106 (51%)
Query: 318 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
+ ++L L +N+I ++ F L EL L+ N + ++ F L NL+ + L++NRL
Sbjct: 72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
Query: 378 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
+ +P +F ++ L + + N++ L +F L L L + DN
Sbjct: 132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDN 177
Score = 46.6 bits (109), Expect = 6e-05
Identities = 25/83 (30%), Positives = 45/83 (54%)
Query: 341 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 400
TE R L L N ++ L+ + F +L+ + L N + + F N+ L + L++N+
Sbjct: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
Query: 401 LENLPLGIFDHLGKLCELRLYDN 423
L+ +PLG+F L L +L + +N
Sbjct: 131 LKLIPLGVFTGLSNLTKLDISEN 153
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 149 bits (375), Expect = 9e-36
Identities = 150/519 (28%), Positives = 235/519 (45%), Gaps = 82/519 (15%)
Query: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMS--------- 57
LLLL A GAGL CP+ C+C R ++C+ ++ P P W A+S
Sbjct: 32 LLLL---PAAGAGL----CPAPCSC-RIPLLDCSRRKL---PAP-SWRALSGLLPPDTAI 79
Query: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
L + ++ N S L L +++ NEL+ I P ++ LSL +N + +
Sbjct: 80 LDFSHNRLSNWNIS--LESQTLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEIN 136
Query: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LT 176
Q +LESL LSSN + +I+ + F + LK L L N + + G FD+L L
Sbjct: 137 AQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLL 195
Query: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236
+ L +N ++ I P++F+ L +LQ L L NR+ + TF GL +L+ L +Q+N I L
Sbjct: 196 VVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKL 254
Query: 237 SPGLF------------HNN------------HNLQRLYLSNNHISQLPPSIFMQLPQLN 272
G F HNN LQ+LY+S N I ++ P + +L+
Sbjct: 255 KDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLS 314
Query: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
L L N L L F + L L L DN ++ + D VF L LQ L L N+IS+
Sbjct: 315 ELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWA 374
Query: 333 ---SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389
+ AF GLT L +L L N ++ + F L +L+++ L NN + + N F+ +
Sbjct: 375 IEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH 434
Query: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDT 449
L EL L + CD + L WL+ N + +
Sbjct: 435 -------------------------LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNV 469
Query: 450 VPVCFSPANVRGQSLIIINVNVAVPSVHV-PEVPSYPET 487
C P + GQS++ +++ V + P++ ++PET
Sbjct: 470 --SCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPET 506
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 145 bits (366), Expect = 1e-34
Identities = 135/462 (29%), Positives = 207/462 (44%), Gaps = 45/462 (9%)
Query: 8 LLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITE 67
+L++ + G G A CP +C CS+ V+C G + P LP + L + N + +
Sbjct: 99 VLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEK 158
Query: 68 LNESPFLNISALIALRIEKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
+ + L L ++ N L+ + AF +L +L YL LANNKL + P L L
Sbjct: 159 IYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALI 218
Query: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL--EYIPDGAFD------------- 170
S++ ++N L +I F Q NL+ + LH N L +PD F+
Sbjct: 219 SVD---FAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSN 275
Query: 171 -------HL-VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD--IPMGTFDGL 220
HL L KL+L N L I P F L +L+ L L N LTD + TF L
Sbjct: 276 FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKL 335
Query: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280
+L+ L L N + + GL +L L+L N I + ++ + L L L N
Sbjct: 336 SSLEYLDLSSNNLSRVPAGL---PRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQ 392
Query: 281 LKELSLG--IFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 338
L+E + F + L + LY+N + +P + +R L +L NQI+ I F
Sbjct: 393 LREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGREDFA 449
Query: 339 GLTELRELSLHTNAL--QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQL 396
L EL+L N + + + FR L L+++ L NRL LP + NV+ +++
Sbjct: 450 TTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVH---VLKV 506
Query: 397 QNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438
+ N+L L G + +L EL L N R S L R W+
Sbjct: 507 KRNELAALARGALVGMAQLRELYLTSN--RLRSRALGPRAWV 546
Score = 73.2 bits (178), Expect = 6e-13
Identities = 83/323 (25%), Positives = 133/323 (41%), Gaps = 55/323 (17%)
Query: 32 SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSR 91
S ++ + + VP LP + + L + I ++ + I +L L + N+L
Sbjct: 336 SSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE 395
Query: 92 --ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCS 149
I P AF+ L L + L NN L+ +P GL + + +L++ NQ+ I F+
Sbjct: 396 QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTY 452
Query: 150 NLKELQLHGNHLE--YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 207
L+EL L N + + AF L L L+L N L + P + + N+ VL++ N
Sbjct: 453 FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPR---NVHVLKVKRN 509
Query: 208 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPG------LFHNN----------------- 244
L + G G+ L+EL L N++ + G L H
Sbjct: 510 ELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLP 569
Query: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
+L+ LYL NN IS +P + F P L + L N L
Sbjct: 570 ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA---------------------- 607
Query: 305 ISSLPDNVFSNLRQLQVLILSRN 327
+ S+ D+ F L+ LQVL + N
Sbjct: 608 VGSVVDSAFRRLKHLQVLDIEGN 630
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 140 bits (354), Expect = 2e-33
Identities = 124/444 (27%), Positives = 188/444 (42%), Gaps = 80/444 (18%)
Query: 24 GCPSECTCS-RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 82
GCP+ C C+ + V CT R+ AVP +P
Sbjct: 24 GCPARCECTVQTRAVACTRRRLTAVPDGIP------------------------------ 53
Query: 83 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
R L L+ N+++ L G L +LE L LS N + ++P
Sbjct: 54 ------------------AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEP 95
Query: 143 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 202
F+ L+ L+L GN L+ IP G F L LT L+L +N L + FQ L +L+ L
Sbjct: 96 GAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRL 155
Query: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
+ +N L + F GL+ L+EL L++ + LS + +L L L + I+ L
Sbjct: 156 EVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLED 215
Query: 263 SIFMQLPQLNRLTLFG-NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321
F +LP L L + L+E++ G + NL L + +I+++P + L
Sbjct: 216 QNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTC 274
Query: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381
L LS N IS + G+F L LREL L L ++ F L ++ ++L NN L L
Sbjct: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
Query: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 441
+ F +VN L LR+ NP CD +L W++
Sbjct: 335 ESTFHSVNTLET------------------------LRVDGNPLACDCRLL----WIVQR 366
Query: 442 QPRLGTD-TVPVCFSPANVRGQSL 464
+ L D +P C +PA VRG +L
Sbjct: 367 RKTLNFDGRLPACATPAEVRGDAL 390
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 138 bits (347), Expect = 2e-32
Identities = 137/462 (29%), Positives = 205/462 (44%), Gaps = 49/462 (10%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP C+C R V+C G + P + A L + N + EL + +S L L +
Sbjct: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
Query: 85 EKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
N +S + AF +L L++L +A+NKL V P L + SL L++NQ+++I P
Sbjct: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPR---SLRVADLAANQVMEIFP 160
Query: 143 AHFSQCSNLKELQLHGNHLEY--IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200
F + L+ + LH N L +P AF + L+L N L+++ P + +L+
Sbjct: 161 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217
Query: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFHNNHNLQRLYLSNNHIS 258
L L N ++ +P G L+EL LQ NQ+ L F H+L+ L LS+N ++
Sbjct: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277
Query: 259 QLPPSIFMQLPQL----NR-----------------LTLFGNSL--KELSLGIFGPMPNL 295
+P + L L NR L L N L L G P+ L
Sbjct: 278 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 337
Query: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 355
L LY N + +P + R+L+ L+L N ++ + L EL+L N L
Sbjct: 338 HTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLAS 394
Query: 356 --LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413
+ FR L L+++ L N+L +LP + GL +QLQ NQL L L
Sbjct: 395 ARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLD 451
Query: 414 KLCELRLYDNPWRCDSDILPLRNW----LLLNQPRLGTDTVP 451
+L EL L N R DI P W L + RL + TVP
Sbjct: 452 QLRELSLAHNRLRV-GDIGP-GTWHELQALQVRHRLVSHTVP 491
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 138 bits (347), Expect = 2e-32
Identities = 137/462 (29%), Positives = 205/462 (44%), Gaps = 49/462 (10%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP C+C R V+C G + P + A L + N + EL + +S L L +
Sbjct: 46 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 105
Query: 85 EKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
N +S + AF +L L++L +A+NKL V P L + SL L++NQ+++I P
Sbjct: 106 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPR---SLRVADLAANQVMEIFP 162
Query: 143 AHFSQCSNLKELQLHGNHLEY--IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200
F + L+ + LH N L +P AF + L+L N L+++ P + +L+
Sbjct: 163 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 219
Query: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFHNNHNLQRLYLSNNHIS 258
L L N ++ +P G L+EL LQ NQ+ L F H+L+ L LS+N ++
Sbjct: 220 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 279
Query: 259 QLPPSIFMQLPQL----NR-----------------LTLFGNSL--KELSLGIFGPMPNL 295
+P + L L NR L L N L L G P+ L
Sbjct: 280 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 339
Query: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 355
L LY N + +P + R+L+ L+L N ++ + L EL+L N L
Sbjct: 340 HTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLAS 396
Query: 356 --LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413
+ FR L L+++ L N+L +LP + GL +QLQ NQL L L
Sbjct: 397 ARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLD 453
Query: 414 KLCELRLYDNPWRCDSDILPLRNW----LLLNQPRLGTDTVP 451
+L EL L N R DI P W L + RL + TVP
Sbjct: 454 QLRELSLAHNRLRV-GDIGP-GTWHELQALQVRHRLVSHTVP 493
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 135 bits (339), Expect = 1e-31
Identities = 92/289 (31%), Positives = 135/289 (46%), Gaps = 9/289 (3%)
Query: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
LNL +N+ ++ F+ + NL L L ++ ++ G F GL L L L N I +L
Sbjct: 56 LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
Query: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
G F + L LYL +N +++LP + L L L L N ++EL G F +LR
Sbjct: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
Query: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
L+L +N +SSL ++ L + RNQ+S A + L + EL L N L+ +
Sbjct: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
Query: 358 GNVFRMLAN-LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI-FDHLGKL 415
N F+ L+ + L N L + F V L + L+NN+L LP FD L L
Sbjct: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETL 295
Query: 416 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 464
L +NPW+C + LR WL R C SPA +GQ +
Sbjct: 296 A---LTNNPWKCTCQLRGLRRWLEAKASRPDA----TCASPAKFKGQHI 337
Score = 102 bits (253), Expect = 1e-21
Identities = 91/338 (26%), Positives = 144/338 (42%), Gaps = 14/338 (4%)
Query: 7 LLLLVGCQAWGAGLAYHGCPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHI 65
LLL +G A G A CP C C S V C + +P + L + +
Sbjct: 6 LLLSLGLLA-GLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
Query: 66 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
L + F + L++L ++ ++ + GAFR L L YL L++N ++VL G F L
Sbjct: 64 PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
Query: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
L L L N++ ++ S NL LQL+ N + + GAF L L L +N+L
Sbjct: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
Query: 186 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-N 244
+ + P + NL + N+L+ P L ++EL L N + + F +
Sbjct: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFG 243
Query: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
L+ L+L N ++ + F+ + L + L N L +L P +L L L +N
Sbjct: 244 RYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNN- 300
Query: 305 ISSLPDNVFSNLRQLQVLI---LSRNQISFISPGAFNG 339
P LR L+ + SR + SP F G
Sbjct: 301 ----PWKCTCQLRGLRRWLEAKASRPDATCASPAKFKG 334
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 134 bits (337), Expect = 2e-31
Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)
Query: 25 CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 72
CP +C C A+ V+C + AVP LP +L + + I +++S
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 73 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 132
++ L L + +N S F L L L L N+L L F GL SL+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 133 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 192
+ NQL +I P FS SNL L L+ N L I F+ L L L +G N + I
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 193 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 252
F+ L NL+ L L L +I +GL +L+ L+ NQ
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
Query: 253 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 311
++++P Q+P L L L N L+ + G F M +L+EL L + + S+
Sbjct: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
Query: 312 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 370
NL +L L ++ N ++SFI P AF+ L ++ L L+ NAL L L NLQ +
Sbjct: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 371 SLQNNRLR 378
L N +R
Sbjct: 365 GLHGNPIR 372
Score = 125 bits (315), Expect = 8e-29
Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)
Query: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187
++LLL SN ++++ + +NL EL L N D F L L L+L +N LT
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 188 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 247
+ F L +LQ L L N+L I F GL NL L L N + + F NL
Sbjct: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
Query: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
+ L + N + + F L L L L G +L+E+S + +L L YDN ++
Sbjct: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 366
+P + L+ L L++N + + PG F + L+EL L+ L +D L
Sbjct: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
Query: 367 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425
L + + NN RL + F ++ + + L NN L L + L L E+ L+ NP
Sbjct: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
Query: 426 RCD 428
RCD
Sbjct: 372 RCD 374
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
G L L NS+ + +L NL L L +N +D F L L L L++NQ+
Sbjct: 70 GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
L F +LQ LYL++N + ++ P F L L RL L N L+ + F +P
Sbjct: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
Query: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
NL L + N + ++ D F L L+ L+L+ + IS A GL L LS + N L
Sbjct: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
Query: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 412
+ + L+ + L N L+++ FAN+ L + L N +L ++ +L
Sbjct: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
Query: 413 GKLCELRLYDNP 424
+L +L + +NP
Sbjct: 310 PELTKLDITNNP 321
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 134 bits (337), Expect = 2e-31
Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)
Query: 25 CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 72
CP +C C A+ V+C + AVP LP +L + + I +++S
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 73 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 132
++ L L + +N S F L L L L N+L L F GL SL+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 133 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 192
+ NQL +I P FS SNL L L+ N L I F+ L L L +G N + I
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 193 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 252
F+ L NL+ L L L +I +GL +L+ L+ NQ
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
Query: 253 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 311
++++P Q+P L L L N L+ + G F M +L+EL L + + S+
Sbjct: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
Query: 312 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 370
NL +L L ++ N ++SFI P AF+ L ++ L L+ NAL L L NLQ +
Sbjct: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 371 SLQNNRLR 378
L N +R
Sbjct: 365 GLHGNPIR 372
Score = 125 bits (315), Expect = 8e-29
Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)
Query: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187
++LLL SN ++++ + +NL EL L N D F L L L+L +N LT
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 188 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 247
+ F L +LQ L L N+L I F GL NL L L N + + F NL
Sbjct: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
Query: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
+ L + N + + F L L L L G +L+E+S + +L L YDN ++
Sbjct: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 366
+P + L+ L L++N + + PG F + L+EL L+ L +D L
Sbjct: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
Query: 367 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425
L + + NN RL + F ++ + + L NN L L + L L E+ L+ NP
Sbjct: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
Query: 426 RCD 428
RCD
Sbjct: 372 RCD 374
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
G L L NS+ + +L NL L L +N +D F L L L L++NQ+
Sbjct: 70 GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
L F +LQ LYL++N + ++ P F L L RL L N L+ + F +P
Sbjct: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
Query: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
NL L + N + ++ D F L L+ L+L+ + IS A GL L LS + N L
Sbjct: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
Query: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 412
+ + L+ + L N L+++ FAN+ L + L N +L ++ +L
Sbjct: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
Query: 413 GKLCELRLYDNP 424
+L +L + +NP
Sbjct: 310 PELTKLDITNNP 321
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 133 bits (335), Expect = 4e-31
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
CP +C C + C +VP ++ L + + HITEL F + S L L +
Sbjct: 34 CPPKCRCEKLL-FYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHL 92
Query: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
+ N++S + AF QGL L+ L+LSSN++ +
Sbjct: 93 DHNQISTVKEDAF------------------------QGLYKLKELILSSNKIFYLPNTT 128
Query: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
F+Q NL+ L L N L + F L L L+L NSL I R+F +L+ L L
Sbjct: 129 FTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDL 188
Query: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
NRL + F GL+ L+EL L+ NQ+ ++ F +L L+L N IS L +
Sbjct: 189 STNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGM 248
Query: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
L +L L GN +K + L +F MPNL+ L + +N ++SL + ++LR L + L
Sbjct: 249 EWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGL 308
Query: 325 SRN 327
S N
Sbjct: 309 SGN 311
Score = 122 bits (305), Expect = 1e-27
Identities = 88/292 (30%), Positives = 138/292 (47%), Gaps = 2/292 (0%)
Query: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
G L+L N +T + F L L L N+++ + F GL L+EL L N+I
Sbjct: 62 GSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKI 121
Query: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
L F NLQ L LS N +S L P +F L +L L L NSL+ + + +F
Sbjct: 122 FYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCR 181
Query: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
+L L L N + SL N F+ L +L+ L L NQ++ I+ F L+ L L L N +
Sbjct: 182 SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI 241
Query: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413
+L + L+ + L N ++ + +F + L + + NN+L +L I + L
Sbjct: 242 SNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLR 301
Query: 414 KLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 465
L + L N W C + I L +WL Q R + +C SP + +G+ ++
Sbjct: 302 SLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 133 bits (335), Expect = 4e-31
Identities = 117/374 (31%), Positives = 173/374 (46%), Gaps = 34/374 (9%)
Query: 6 YLLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTH 64
+LLLL G G+G CP+ C C+ Q V C ++ AVP LP + L +
Sbjct: 19 FLLLLPG----GSG---GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNR 71
Query: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
+ L + +S L L + N+LS + PGAF L SL L L N+L+++ G+F GL
Sbjct: 72 LWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGL 131
Query: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
+L L L NQ++ F + +L++L++ NHL ++ GAF L L+ L L + +
Sbjct: 132 SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCN 191
Query: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ-QNQIGLLSPGLFHN 243
L+ + L L LRL E + +P G GL L+EL + + L PG
Sbjct: 192 LSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSL-V 250
Query: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
NL L ++ ++S +P F L L+ LR L L N
Sbjct: 251 GLNLSSLAITRCNLSSVP---FQALYHLS---------------------FLRVLDLSQN 286
Query: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 363
IS++P S L +LQ L LS ++ I+ AF+GLT L + NALQ L+ F
Sbjct: 287 PISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPS 346
Query: 364 LANLQNISLQNNRL 377
L + L N L
Sbjct: 347 PDKLVTLRLSGNPL 360
Score = 116 bits (290), Expect = 6e-26
Identities = 111/362 (30%), Positives = 157/362 (43%), Gaps = 33/362 (9%)
Query: 106 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165
L L+ N+L L G+ L L+ L LS NQL ++P F +L L+L GN L +
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 166 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 225
G F L LT L+L N + F LG+LQ L + +N L + G F GL L
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 226 LALQQNQIGLLSPGL-FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTL-FGNSLKE 283
L L++ + + PGL L L L I +LP L QL L + SL+
Sbjct: 185 LTLERCNLSTV-PGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEA 243
Query: 284 LSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTEL 343
L G + NL L + ++SS+P +L L+VL LS+N IS I + L L
Sbjct: 244 LDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRL 302
Query: 344 RELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLEN 403
+EL L L + + F L + + +N L+ L F + +
Sbjct: 303 QELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPD-------------- 348
Query: 404 LPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTD-TVPVCFSPANVRGQ 462
KL LRL NP CD +L WLL + L + P C P +V+G+
Sbjct: 349 ----------KLVTLRLSGNPLTCDCRLL----WLLRLRRHLDFGMSPPACAGPHHVQGK 394
Query: 463 SL 464
SL
Sbjct: 395 SL 396
Score = 57.0 bits (136), Expect = 5e-08
Identities = 35/104 (33%), Positives = 56/104 (53%)
Query: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
++L LS N++ + G + L+ L+EL L N L L+ F L +L + LQ NRLR
Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
Query: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
+ +F+ ++ L + L+ NQ+ G F LG L +L + DN
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDN 166
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/159 (27%), Positives = 62/159 (38%), Gaps = 24/159 (15%)
Query: 76 ISALIALRIEKNELSRITPGAFRNLGSLRYL------------------------SLANN 111
+ AL+ALR+ + ++ R+ GA R LG L+ L ++
Sbjct: 203 LPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRC 262
Query: 112 KLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDH 171
L +P L L L LS N + I S L+EL+L G L I AF
Sbjct: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322
Query: 172 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT 210
L L++ N+L + F L LRL N LT
Sbjct: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,898,852
Number of Sequences: 37866
Number of extensions: 975428
Number of successful extensions: 7923
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 3151
Number of HSP's gapped (non-prelim): 1794
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.