Search of human proteins with 18497288

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18497288 latent transforming growth factor beta binding
protein 3 isoform 2 [Homo sapiens]
         (1256 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18497288 latent transforming growth factor beta binding prote...  2769   0.0  
gi|194328809 latent transforming growth factor beta binding prot...  2747   0.0  
gi|46249414 latent transforming growth factor beta binding prote...   974   0.0  
gi|46249412 latent transforming growth factor beta binding prote...   974   0.0  
gi|4557733 latent transforming growth factor beta binding protei...   753   0.0  
gi|110347437 latent transforming growth factor beta binding prot...   613   e-175
gi|110347412 latent transforming growth factor beta binding prot...   588   e-168
gi|110347431 latent transforming growth factor beta binding prot...   588   e-168
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      451   e-126
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      443   e-124
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      441   e-123
gi|118572606 hemicentin 1 [Homo sapiens]                              218   4e-56
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               210   8e-54
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              209   1e-53
gi|148833508 notch1 preproprotein [Homo sapiens]                      207   4e-53
gi|134244285 Notch homolog 3 [Homo sapiens]                           204   4e-52
gi|55770876 notch4 preproprotein [Homo sapiens]                       202   2e-51
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              202   2e-51
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              201   3e-51
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        201   4e-51
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              200   6e-51
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              200   6e-51
gi|24041035 notch 2 preproprotein [Homo sapiens]                      196   9e-50
gi|190343004 EGF-containing fibulin-like extracellular matrix pr...   190   8e-48
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     187   4e-47
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    183   1e-45
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   181   5e-45
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   181   5e-45
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   181   5e-45
gi|19743803 fibulin 5 precursor [Homo sapiens]                        176   1e-43

>gi|18497288 latent transforming growth factor beta binding protein 3
            isoform 2 [Homo sapiens]
          Length = 1256

 Score = 2769 bits (7179), Expect = 0.0
 Identities = 1256/1256 (100%), Positives = 1256/1256 (100%)

Query: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60
            MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
Sbjct: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
Sbjct: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
Sbjct: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240
            SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
Sbjct: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240

Query: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300
            QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
Sbjct: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300

Query: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360
            EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
Sbjct: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420
            MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
Sbjct: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420

Query: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480
            TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
Sbjct: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480

Query: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540
            FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
Sbjct: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540

Query: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
Sbjct: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
Sbjct: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660

Query: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720
            LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
Sbjct: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720

Query: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780
            KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
Sbjct: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840
            RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840

Query: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
            CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
Sbjct: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
            TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
Sbjct: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020
            VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
Sbjct: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
            CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080

Query: 1081 MERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP 1140
            MERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP
Sbjct: 1081 MERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP 1140

Query: 1141 TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDA 1200
            TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDA
Sbjct: 1141 TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDA 1200

Query: 1201 SRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256
            SRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Sbjct: 1201 SRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score = 2747 bits (7121), Expect = 0.0
 Identities = 1256/1303 (96%), Positives = 1256/1303 (96%), Gaps = 47/1303 (3%)

Query: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60
            MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
Sbjct: 1    MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE 60

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
Sbjct: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
Sbjct: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240
            SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
Sbjct: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV 240

Query: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300
            QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
Sbjct: 241  QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ 300

Query: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360
            EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
Sbjct: 301  EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA 360

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420
            MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
Sbjct: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT 420

Query: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480
            TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
Sbjct: 421  TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL 480

Query: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540
            FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
Sbjct: 481  FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP 540

Query: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
Sbjct: 541  ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
Sbjct: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660

Query: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720
            LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
Sbjct: 661  LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN 720

Query: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780
            KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
Sbjct: 721  KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 780

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840
            RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD 840

Query: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
            CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
Sbjct: 841  CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
            TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
Sbjct: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020
            VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
Sbjct: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY 1020

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
            CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080

Query: 1081 M-----------------------------------------------ERAPERRDVCWS 1093
            M                                               ERAPERRDVCWS
Sbjct: 1081 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS 1140

Query: 1094 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1153
            QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
Sbjct: 1141 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200

Query: 1154 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213
            PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
Sbjct: 1201 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260

Query: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256
            LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  974 bits (2519), Expect = 0.0
 Identities = 545/1419 (38%), Positives = 716/1419 (50%), Gaps = 288/1419 (20%)

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            R KVVF P ICK TC KG C++SC++G+  TLI ENGH+ DTLT + FRVV+C LPCMNG
Sbjct: 351  RIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNG 410

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSR++C CPP+FTG+ CQ+P  GA                    ++P L        
Sbjct: 411  GQCSSRDKCQCPPNFTGKLCQIPVHGA--------------------SVPKLYQHSQQ-- 448

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLG-PGQISAEVQAPPPVVNVRVHHPPEAS 239
                          PG   G    H+   +PL    Q   +V+ PP +VN+ V HPPEAS
Sbjct: 449  --------------PGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEAS 494

Query: 240  VQVHRIESSNAESAAPSQHLLP-HPKPSHPRPPTQKP----------------------- 275
            VQ+H++   +  +   ++   P   + S+   P QK                        
Sbjct: 495  VQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKT 554

Query: 276  -LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
             LGRCFQ+T+  Q CG   LPGL+KQEDCCG++GT+WG +KC KCP+       KP    
Sbjct: 555  QLGRCFQETIGSQ-CGK-ALPGLSKQEDCCGTVGTSWGFNKCQKCPK-------KPSYHG 605

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 +C  GYKR+N+T CQDINEC + GVC +G+CLN  GSYRC C  G    P+ + C
Sbjct: 606  YNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665

Query: 395  IADKP---EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + D P   EEK  C+RLVS   QC HPL+  LT+QLCCCSVGKAWG  C++CP  GTAAF
Sbjct: 666  VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAF 725

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP----PKPQQLPESPSQAPPPEDTE 507
            KEICP G GY +   H+   I             GP    PK  Q P + S  PPP   +
Sbjct: 726  KEICPGGMGYTVSGVHRRRPIHHHVG-------KGPVFVKPKNTQ-PVAKSTHPPPLPAK 777

Query: 508  EER-----------------GVTTDSPVSEERSVQQSH-----------PTATTTPARP- 538
            EE                   V T  P  E  S+ Q             P  +T    P 
Sbjct: 778  EEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQ 837

Query: 539  YPEL-ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDY 597
            +P + I + SPP      P+   S ++  IAPTQVTE +EC +N +ICG G C+  P  Y
Sbjct: 838  FPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRY 897

Query: 598  SCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRS 657
            +C C  GYR   Q R CVD++EC        +G C NT GS+ C C  G+       G +
Sbjct: 898  TCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM--ASEEGTN 955

Query: 658  CVDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            C+D++EC +P +CG+G  C+N  G ++C  C  GYR+  ++   CEDIDEC +PS+CPD 
Sbjct: 956  CIDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDE 1012

Query: 717  KCENKPGSFKCIACQPGYRSQGGGA----------------------------------- 741
            +C N PGS++C+ C  G+R   G                                     
Sbjct: 1013 QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT 1072

Query: 742  -----CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
                 CRD++EC +G+ C  G C+N  GSFRCTC QGY  +     C D+DEC+   +C 
Sbjct: 1073 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 1132

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQG 855
            +G C NT GSFQC C  GY  S    HCEDI+EC +  + C  GDCINT GSY C CP G
Sbjct: 1133 HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG 1192

Query: 856  HRL------------------------------------------VGGRKCQDIDECSQD 873
             +L                                            GR C+DIDEC  +
Sbjct: 1193 FQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNN 1252

Query: 874  PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG------------------CEEVE---- 911
             ++C  HG C N  GS+ C+C +GF   QD  G                  CE VE    
Sbjct: 1253 -TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 1311

Query: 912  ------------------------------QP-HHKKECYLNFDDTVFCDSVLATNVTQQ 940
                                          QP   KKECY N +D   CD+VLA NVT+Q
Sbjct: 1312 CVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ 1371

Query: 941  ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DNNIVNYGIPAHRDIDECML 999
            ECCC+ GAGWGD+CEI+PCPV  +AEF  +CP GKG+     +    G   ++D DEC+L
Sbjct: 1372 ECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLL 1431

Query: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR 1059
            FG EICK G C+NT+PGYECYCKQG YYD   L+C D+DEC D S+C +G C NT G Y 
Sbjct: 1432 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1491

Query: 1060 CACTPPAEYSPAQRQCLSP----EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC 1115
            C CT P     ++++C+ P    E++E     +D+CW    ++ +C+ PL G   T+ +C
Sbjct: 1492 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1551

Query: 1116 CCRQGRGWGAQCRPCPPRGA------------GSHCPTSQSESNSFWD-----TSPLLLG 1158
            CC  G  WG QC  CP + +            G   P  +     F +       P  + 
Sbjct: 1552 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI- 1610

Query: 1159 KPPRDEDSSEE-DSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213
               R  +S EE  ++EC     C +GRCV    G  C+C  G+ LD ++  CVD++EC E
Sbjct: 1611 -QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDE 1669

Query: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            LN R  LCK+ +C+NT GS++C+C  G+  S     C P
Sbjct: 1670 LNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTP 1708



 Score =  180 bits (457), Expect = 7e-45
 Identities = 152/575 (26%), Positives = 224/575 (38%), Gaps = 128/575 (22%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGIC 632
            + +EC  ++++C  G+C+     Y C C  G++    ++ C D+NECE    CGP +G C
Sbjct: 1162 DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP-QGEC 1219

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
            +NT GS++C C +G+   + A GR+C D++EC    +C   GFC N  G ++C CY G++
Sbjct: 1220 LNTEGSFHCVCQQGFS--ISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1277

Query: 693  LKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYR-SQGGGACR------- 743
                    C D++EC   S  C +  CEN  GSF C+        S   G CR       
Sbjct: 1278 APQDGQG-CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDL 1336

Query: 744  ---------DVNECA----EGSPCS-----------------PGW---CENLPGSF---- 766
                     +  EC     + S C                   GW   CE  P       
Sbjct: 1337 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTA 1396

Query: 767  ----RCTCAQGYAPAPD------GRSCLDVDECE--AGDVCDNGICSNTPGSFQCQCLSG 814
                 C   +G+ PA +      G +  D DEC     ++C NG C NT   ++C C  G
Sbjct: 1397 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1456

Query: 815  YHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-C-------QD 866
             +    +  C D+DEC  P++CI G C+NT GSY C C     L    K C       + 
Sbjct: 1457 TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQ 1516

Query: 867  IDECSQDPSLCLPHGACKNL--------QGSYV-CVCDEG--------FTPTQDQHGCEE 909
            I+E      LC  H + + +        Q +Y  C C  G          P +D     +
Sbjct: 1517 IEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1576

Query: 910  V--------EQPHHK------KECYLNFDDTVFCDSVLATNVT--QQECCCSLGAGWGDH 953
            +         QP+ +       E Y    D  F       +    Q E C  L       
Sbjct: 1577 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGR 1636

Query: 954  C----EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE--ICKE 1007
            C    E Y C  +             GY  D   +        D++EC    +   +CK 
Sbjct: 1637 CVRVQEGYTCDCFD------------GYHLDTAKMTCV-----DVNECDELNNRMSLCKN 1679

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
             KC+NT   Y+C C  G+        C  ++  L+
Sbjct: 1680 AKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALN 1714



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 31/107 (28%), Positives = 40/107 (37%), Gaps = 12/107 (11%)

Query: 113 CPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGT--GGSGPGLSRTGALSTGALP 170
           C  PC NGG C     C+C P   G+ C+  A         GG  P     GA S+   P
Sbjct: 191 CVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSP-----GAASSWGPP 245

Query: 171 PLAPEGDSVASKHAIYAVQVIAD-----PPGPGEGPPAQHAAFLVPL 212
             A +  S      +  V  +A       P P  G P Q  + + PL
Sbjct: 246 EQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPL 292



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 15/47 (31%), Positives = 22/47 (46%)

Query: 572  VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            V E DE     ++C + +C+     Y C C PGY    +  YC  +N
Sbjct: 1664 VNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 36/130 (27%), Positives = 44/130 (33%), Gaps = 30/130 (23%)

Query: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA-----------CQPGYRSQG 738
           G  L+  RPP     +  R   + P G+    PG     A            +    +Q 
Sbjct: 92  GAALQGLRPPPPPPPEPARP--AVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQS 149

Query: 739 GGACR----------DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788
           GG  R           VN C  G  C  GW +  PGS RCT      P  +G  CL    
Sbjct: 150 GGGSRLQVHQKQQLQGVNVC--GGRCCHGWSK-APGSQRCTKPSCVPPCQNGGMCLRPQL 206

Query: 789 CEAGDVCDNG 798
           C    VC  G
Sbjct: 207 C----VCKPG 212


>gi|46249412 latent transforming growth factor beta binding protein 1
            isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  974 bits (2519), Expect = 0.0
 Identities = 545/1419 (38%), Positives = 716/1419 (50%), Gaps = 288/1419 (20%)

Query: 61   RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG 120
            R KVVF P ICK TC KG C++SC++G+  TLI ENGH+ DTLT + FRVV+C LPCMNG
Sbjct: 25   RIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNG 84

Query: 121  GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA 180
            GQCSSR++C CPP+FTG+ CQ+P  GA                    ++P L        
Sbjct: 85   GQCSSRDKCQCPPNFTGKLCQIPVHGA--------------------SVPKLYQHSQQ-- 122

Query: 181  SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLG-PGQISAEVQAPPPVVNVRVHHPPEAS 239
                          PG   G    H+   +PL    Q   +V+ PP +VN+ V HPPEAS
Sbjct: 123  --------------PGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEAS 168

Query: 240  VQVHRIESSNAESAAPSQHLLP-HPKPSHPRPPTQKP----------------------- 275
            VQ+H++   +  +   ++   P   + S+   P QK                        
Sbjct: 169  VQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKT 228

Query: 276  -LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR 334
             LGRCFQ+T+  Q CG   LPGL+KQEDCCG++GT+WG +KC KCP+       KP    
Sbjct: 229  QLGRCFQETIGSQ-CGK-ALPGLSKQEDCCGTVGTSWGFNKCQKCPK-------KPSYHG 279

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 +C  GYKR+N+T CQDINEC + GVC +G+CLN  GSYRC C  G    P+ + C
Sbjct: 280  YNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339

Query: 395  IADKP---EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + D P   EEK  C+RLVS   QC HPL+  LT+QLCCCSVGKAWG  C++CP  GTAAF
Sbjct: 340  VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAF 399

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP----PKPQQLPESPSQAPPPEDTE 507
            KEICP G GY +   H+   I             GP    PK  Q P + S  PPP   +
Sbjct: 400  KEICPGGMGYTVSGVHRRRPIHHHVG-------KGPVFVKPKNTQ-PVAKSTHPPPLPAK 451

Query: 508  EER-----------------GVTTDSPVSEERSVQQSH-----------PTATTTPARP- 538
            EE                   V T  P  E  S+ Q             P  +T    P 
Sbjct: 452  EEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQ 511

Query: 539  YPEL-ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDY 597
            +P + I + SPP      P+   S ++  IAPTQVTE +EC +N +ICG G C+  P  Y
Sbjct: 512  FPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRY 571

Query: 598  SCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRS 657
            +C C  GYR   Q R CVD++EC        +G C NT GS+ C C  G+       G +
Sbjct: 572  TCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM--ASEEGTN 629

Query: 658  CVDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            C+D++EC +P +CG+G  C+N  G ++C  C  GYR+  ++   CEDIDEC +PS+CPD 
Sbjct: 630  CIDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDE 686

Query: 717  KCENKPGSFKCIACQPGYRSQGGGA----------------------------------- 741
            +C N PGS++C+ C  G+R   G                                     
Sbjct: 687  QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT 746

Query: 742  -----CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
                 CRD++EC +G+ C  G C+N  GSFRCTC QGY  +     C D+DEC+   +C 
Sbjct: 747  PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 806

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQG 855
            +G C NT GSFQC C  GY  S    HCEDI+EC +  + C  GDCINT GSY C CP G
Sbjct: 807  HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG 866

Query: 856  HRL------------------------------------------VGGRKCQDIDECSQD 873
             +L                                            GR C+DIDEC  +
Sbjct: 867  FQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNN 926

Query: 874  PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG------------------CEEVE---- 911
             ++C  HG C N  GS+ C+C +GF   QD  G                  CE VE    
Sbjct: 927  -TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 985

Query: 912  ------------------------------QP-HHKKECYLNFDDTVFCDSVLATNVTQQ 940
                                          QP   KKECY N +D   CD+VLA NVT+Q
Sbjct: 986  CVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ 1045

Query: 941  ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DNNIVNYGIPAHRDIDECML 999
            ECCC+ GAGWGD+CEI+PCPV  +AEF  +CP GKG+     +    G   ++D DEC+L
Sbjct: 1046 ECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLL 1105

Query: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR 1059
            FG EICK G C+NT+PGYECYCKQG YYD   L+C D+DEC D S+C +G C NT G Y 
Sbjct: 1106 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1165

Query: 1060 CACTPPAEYSPAQRQCLSP----EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC 1115
            C CT P     ++++C+ P    E++E     +D+CW    ++ +C+ PL G   T+ +C
Sbjct: 1166 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1225

Query: 1116 CCRQGRGWGAQCRPCPPRGA------------GSHCPTSQSESNSFWD-----TSPLLLG 1158
            CC  G  WG QC  CP + +            G   P  +     F +       P  + 
Sbjct: 1226 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI- 1284

Query: 1159 KPPRDEDSSEE-DSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213
               R  +S EE  ++EC     C +GRCV    G  C+C  G+ LD ++  CVD++EC E
Sbjct: 1285 -QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDE 1343

Query: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            LN R  LCK+ +C+NT GS++C+C  G+  S     C P
Sbjct: 1344 LNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTP 1382



 Score =  180 bits (457), Expect = 7e-45
 Identities = 152/575 (26%), Positives = 224/575 (38%), Gaps = 128/575 (22%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGIC 632
            + +EC  ++++C  G+C+     Y C C  G++    ++ C D+NECE    CGP +G C
Sbjct: 836  DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP-QGEC 893

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
            +NT GS++C C +G+   + A GR+C D++EC    +C   GFC N  G ++C CY G++
Sbjct: 894  LNTEGSFHCVCQQGFS--ISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 951

Query: 693  LKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYR-SQGGGACR------- 743
                    C D++EC   S  C +  CEN  GSF C+        S   G CR       
Sbjct: 952  APQDGQG-CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDL 1010

Query: 744  ---------DVNECA----EGSPCS-----------------PGW---CENLPGSF---- 766
                     +  EC     + S C                   GW   CE  P       
Sbjct: 1011 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTA 1070

Query: 767  ----RCTCAQGYAPAPD------GRSCLDVDECE--AGDVCDNGICSNTPGSFQCQCLSG 814
                 C   +G+ PA +      G +  D DEC     ++C NG C NT   ++C C  G
Sbjct: 1071 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1130

Query: 815  YHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-C-------QD 866
             +    +  C D+DEC  P++CI G C+NT GSY C C     L    K C       + 
Sbjct: 1131 TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQ 1190

Query: 867  IDECSQDPSLCLPHGACKNL--------QGSYV-CVCDEG--------FTPTQDQHGCEE 909
            I+E      LC  H + + +        Q +Y  C C  G          P +D     +
Sbjct: 1191 IEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1250

Query: 910  V--------EQPHHK------KECYLNFDDTVFCDSVLATNVT--QQECCCSLGAGWGDH 953
            +         QP+ +       E Y    D  F       +    Q E C  L       
Sbjct: 1251 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGR 1310

Query: 954  C----EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE--ICKE 1007
            C    E Y C  +             GY  D   +        D++EC    +   +CK 
Sbjct: 1311 CVRVQEGYTCDCFD------------GYHLDTAKMTCV-----DVNECDELNNRMSLCKN 1353

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
             KC+NT   Y+C C  G+        C  ++  L+
Sbjct: 1354 AKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALN 1388



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 15/47 (31%), Positives = 22/47 (46%)

Query: 572  VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            V E DE     ++C + +C+     Y C C PGY    +  YC  +N
Sbjct: 1338 VNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  753 bits (1945), Expect = 0.0
 Identities = 466/1314 (35%), Positives = 623/1314 (47%), Gaps = 245/1314 (18%)

Query: 60   ERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMN 119
            ++ K+VF P ICK+TC +G C +SC++G   TL  + GH  D    SGFR+  C +PC+N
Sbjct: 349  KKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK--SGFRIYFCQIPCLN 406

Query: 120  GGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSV 179
            GG+C  R++C CP + TG+FC +P                              P+ D  
Sbjct: 407  GGRCIGRDECWCPANSTGKFCHLP-----------------------------IPQPD-- 435

Query: 180  ASKHAIYAVQVIADPPGPGEGP------PAQHAAFLVPLGPGQISAEVQAPPPVVNVRVH 233
                         +PPG G  P      P + + F +PL     S      P +V V +H
Sbjct: 436  ------------REPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVN----PSLVKVHIH 479

Query: 234  HPPEASVQVHRIES----------SNAESAAPSQHLLPHP---------------KPSHP 268
            HPPEASVQ+H++             N+    P   L   P               +P  P
Sbjct: 480  HPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRP 539

Query: 269  RPP-TQKP---LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY 324
             PP   +P   LGRC+ +T+  Q C +NPL  LT QEDCCGS+G  WG + C  CP    
Sbjct: 540  LPPAAPRPRGLLGRCYLNTVNGQ-C-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPA 597

Query: 325  TGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            + V + G +      +CPQGYKRLN THCQDINEC   G+C+  +C+N  GSY C C PG
Sbjct: 598  SPVIENGQL------ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG 651

Query: 385  HSLGPSRTQCIADKPEE--KSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQ 441
              L PSR++C++DK     + LC+R + P   C  PL  R+T+Q+CCCS VGKAWG+ C+
Sbjct: 652  LMLDPSRSRCVSDKAISMLQGLCYRSLGP-GTCTLPLAQRITKQICCCSRVGKAWGSECE 710

Query: 442  RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAP 501
            +CP  GT AF+EICPAG GY   +S   L+++   +  L       P  +Q   S    P
Sbjct: 711  KCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEEL-----ARPPREQGQRSSGALP 765

Query: 502  PPEDTEEERGVT---TDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDL 558
             P + +  R VT    ++    ++   Q+    T+    P     +  +PP         
Sbjct: 766  GPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPM-------- 817

Query: 559  PPSRSAVEIAPTQVTET------------DECRLN-QNICGHGECVPGPPDYSCHCNPGY 605
             P +   EI   QVT +            D C     N+CG G CV  P  Y C C+PGY
Sbjct: 818  -PEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGY 876

Query: 606  RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
            + HP   YC D NEC  +PC  G+G C+N  GSY+C C  GY L      + C D+NEC 
Sbjct: 877  QLHPSQAYCTDDNECLRDPC-KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE 935

Query: 666  KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSF 725
            +P +C  GG C N  G Y C C  GY +   R   C+DI+ECR P +CPDG+C N PGS+
Sbjct: 936  QPGVC-SGGQCTNTEGSYHCECDQGYIM--VRKGHCQDINECRHPGTCPDGRCVNSPGSY 992

Query: 726  KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
             C+AC+ GYR Q  G+C DVNEC     C+ G C NL GSFRC+C QGY    D + C D
Sbjct: 993  TCLACEEGYRGQ-SGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD 1051

Query: 786  VDECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
            VDEC +   C  G+C NT GSF C  C +GY ++ D + CED+DEC FP  C  G C NT
Sbjct: 1052 VDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNT 1111

Query: 845  NGSYRCL-CPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF---- 898
             GS+ C  C  G+R    G  C+D+DEC    S CL  G CKN  GSY C+C +GF    
Sbjct: 1112 AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLAN 1170

Query: 899  -TPTQDQHGCEEVEQPHHKKECYLNFDDTVFC-------DSVLATNVTQQECCCSLGAGW 950
             T  +D + C   E      EC LN   + FC        +   T+    + C +     
Sbjct: 1171 GTVCEDVNECMGEEHCAPHGEC-LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCV 1229

Query: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKC 1010
            G HC      V +   F+ LC  G   + ++           DIDEC  +G  +C   KC
Sbjct: 1230 GGHC------VNTEGSFNCLCETGFQPSPESG-------ECVDIDECEDYGDPVCGTWKC 1276

Query: 1011 VNTQPGYECY--CKQGFYYDGNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAE 1067
             N+   Y C   C+ GF+   N  +C+D+DEC +++ C  +G C+NT G +RC C    E
Sbjct: 1277 ENSPGSYRCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335

Query: 1068 YSPAQRQCLSPEEME--RAPERRDVCWSQRG---------------EDGMCAGPLAG--- 1107
             SP+   C+   E E   A     +C +  G               ++G C    AG   
Sbjct: 1336 ISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQS 1395

Query: 1108 ----------PALTFDD-----------------------CCCRQGRGWGAQCRPCPPRG 1134
                      PA T  D                       CCC QG  WG  C  CP   
Sbjct: 1396 MSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCP--- 1452

Query: 1135 AGSHCPTSQSESNSFWDTSPLLLGKPPRD-----EDSSEEDSDEC------RCVSGRCVP 1183
                      +S  F +  P   G  P +       +   D+DEC       C +GRC+ 
Sbjct: 1453 --------SEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLN 1504

Query: 1184 RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVC 1237
               G VC C  GF  DAS  +C D DEC++     L C++  CVNT GSF C C
Sbjct: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDECQD-----LACENGECVNTEGSFHCFC 1553



 Score =  437 bits (1125), Expect = e-122
 Identities = 269/789 (34%), Positives = 366/789 (46%), Gaps = 136/789 (17%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC L   +C HG+C      + C C  GY      + C DV+EC +    P  G+C+
Sbjct: 1010 DVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP-TGLCL 1067

Query: 634  NTGGSYNCH-CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKC-NCYPGY 691
            NT GS+ C  C  GY   V   G +C DL+ECA P +C   G C N  G + C +C  GY
Sbjct: 1068 NTEGSFACSACENGY--WVNEDGTACEDLDECAFPGVC-PSGVCTNTAGSFSCKDCDGGY 1124

Query: 692  RLKASRPPVCEDIDECRDP-SSCPDGKCENKPGSFKCIA--------------------- 729
            R  +     CED+DEC DP SSC  G+C+N  GS++C+                      
Sbjct: 1125 R-PSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGE 1183

Query: 730  -------------------CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCT 769
                               C PG+ S +GG +C+DV+ECA   PC  G C N  GSF C 
Sbjct: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCL 1243

Query: 770  CAQGYAPAPDGRSCLDVDECEA-GD-VCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCE 825
            C  G+ P+P+   C+D+DECE  GD VC    C N+PGS++C   C  G+H++ +   C 
Sbjct: 1244 CETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN-GDCI 1302

Query: 826  DIDECDFPAACIG-GDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA- 882
            DIDEC     C   G C NT+GS+RCLC QG  +   G  C D++EC    ++C   GA 
Sbjct: 1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVC---GAA 1359

Query: 883  -CKNLQGSYVCVCDEGFTPTQDQHG-----------CEEVEQPHH-----KKECYLNFDD 925
             C+N++GS++C+C         Q G             E     H     + +CY     
Sbjct: 1360 LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG 1419

Query: 926  TVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVN 985
               C SVL  N TQ ECCC+ GA WGD C++  CP   SAEF  +CP GKGY        
Sbjct: 1420 HAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSEDSAEFSEICPSGKGYIPVEGAWT 1477

Query: 986  YGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN 1045
            +G   + D DEC++FG  +C  G+C+NT PGY C C  GF+YD +  +C D DEC D + 
Sbjct: 1478 FGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA- 1536

Query: 1046 CRNGVCENTRGGYRCACTPPAEYSPAQRQCL----SPEEMERAPERRDVCWSQRGEDGMC 1101
            C NG C NT G + C C+PP     +Q++C+    S E++       D+CW +   D +C
Sbjct: 1537 CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTND-VC 1595

Query: 1102 AGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG------------------AGSHC---- 1139
            + PL G   T+ +CCC+ G  W  QC  CPPR                   AG H     
Sbjct: 1596 SEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGY 1655

Query: 1140 -----PTSQSESNSFWDTSPLLLGKPPRDE-------DSSEEDSD-----ECRCVSGRCV 1182
                 P     S    D +P      P D        +++   +D     E         
Sbjct: 1656 EYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQ 1715

Query: 1183 PRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFA 1242
            P    +  E P GF+        +  +EC  LN     C++ RCV     + C C  GF 
Sbjct: 1716 PHYVASHPEPPAGFE-------GLQAEECGILNG----CENGRCVRVREGYTCDCFEGFQ 1764

Query: 1243 RSRPHGACV 1251
                H ACV
Sbjct: 1765 LDAAHMACV 1773



 Score =  259 bits (662), Expect = 1e-68
 Identities = 183/577 (31%), Positives = 245/577 (42%), Gaps = 106/577 (18%)

Query: 704  IDECRDPSS--CPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCE 760
            ID C   ++  C  G C N P  ++C+ C PGY+     A C D NEC        G C 
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCV-CSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903

Query: 761  NLPGSFRCTCAQGYAPAPDG--RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLS 818
            N  GS+ C C  GY  A  G  + C D++ECE   VC  G C+NT GS+ C+C  GY + 
Sbjct: 904  NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963

Query: 819  RDRSHCEDIDECDFPAACIGGDCINTNGSYRCL-CPQGHRLVGGRKCQDIDECSQDPSLC 877
            R + HC+DI+EC  P  C  G C+N+ GSY CL C +G+R   G  C D++EC   P +C
Sbjct: 964  R-KGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSG-SCVDVNECLT-PGVC 1020

Query: 878  LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
              HG C NL+GS+ C C++G+  T D+ GC++V+      EC         C + L  N 
Sbjct: 1021 A-HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD------ECA----SRASCPTGLCLNT 1069

Query: 938  TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIP-------- 989
                 C +   G+  + +   C       F  +CP G      N   ++           
Sbjct: 1070 EGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSG---VCTNTAGSFSCKDCDGGYRP 1126

Query: 990  -----AHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044
                 +  D+DEC    S  C  G+C NT   Y+C C QGF    N   C DV+EC+ E 
Sbjct: 1127 SPLGDSCEDVDECEDPQSS-CLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEE 1184

Query: 1045 NCR-NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
            +C  +G C N+ G + C C P    +     C   +E                    CA 
Sbjct: 1185 HCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE--------------------CA- 1223

Query: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
                   T D C                    G HC  ++   N   +T     G  P  
Sbjct: 1224 -------TTDPC-------------------VGGHCVNTEGSFNCLCET-----GFQPSP 1252

Query: 1164 EDSSEEDSDECR------CVSGRCVPRPGGAVCE--CPGGFQLDASRARCVDIDECRELN 1215
            E     D DEC       C + +C   PG   C   C  GF + A    C+DIDEC    
Sbjct: 1253 ESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN-- 1309

Query: 1216 QRGLLCKSER-CVNTSGSFRCVCKAGFARSRPHGACV 1251
                +C S   C NT GSFRC+C  GF  S     CV
Sbjct: 1310 --DTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCV 1344



 Score =  235 bits (599), Expect = 2e-61
 Identities = 238/936 (25%), Positives = 347/936 (37%), Gaps = 194/936 (20%)

Query: 306  SIGTAWGQSKCHKCPQLQYTGVQKPGP---VRGEVGADCPQGYKRLNSTHCQDINECAMP 362
            ++ T+    +C    + +  GV   G      G    +C QGY  +   HCQDINEC  P
Sbjct: 918  TLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHP 977

Query: 363  GVCRHGDCLNNPGSYRCV-CPPGHSLGPSRT-----QCIADKPEEKSLC----------- 405
            G C  G C+N+PGSY C+ C  G+  G S +     +C+         C           
Sbjct: 978  GTCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSC 1036

Query: 406  ---FRLVSPEHQCQH----PLTTRLTRQLCCCSVGKAWGARCQR---CPTDGTA------ 449
               + + S E  CQ              LC  + G    + C+       DGTA      
Sbjct: 1037 EQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096

Query: 450  -AFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEE 508
             AF  +CP+G   +   S                  DG  +P  L +S       ED + 
Sbjct: 1097 CAFPGVCPSGVCTNTAGSFSCKDC------------DGGYRPSPLGDSCEDVDECEDPQS 1144

Query: 509  E--RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISR----PSPPTMR----WFLPDL 558
                G   ++  S +    Q    A  T      E +      P    +     +F    
Sbjct: 1145 SCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204

Query: 559  PPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618
            P   SA     T   + DEC       G G CV     ++C C  G++  P+   CVD++
Sbjct: 1205 PGFVSAE--GGTSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPESGECVDID 1261

Query: 619  ECE--AEP-CGPGRGICMNTGGSYNC--HCNRGYRLHVGAGGRSCVDLNECAKPHLCGDG 673
            ECE   +P CG  +  C N+ GSY C   C  G+  H+   G  C+D++ECA   +CG  
Sbjct: 1262 ECEDYGDPVCGTWK--CENSPGSYRCVLGCQPGF--HMAPNG-DCIDIDECANDTMCGSH 1316

Query: 674  GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIAC-- 730
            GFC N  G ++C C  G+ +  S    C D++EC    + C    CEN  GSF C+    
Sbjct: 1317 GFCDNTDGSFRCLCDQGFEISPSGWD-CVDVNECELMLAVCGAALCENVEGSFLCLCASD 1375

Query: 731  ------QPGYRSQGGGACRDVNECAEG------------------SPCSPGWCENLPGSF 766
                  Q G+    G   + ++E   G                  +PCS     N   + 
Sbjct: 1376 LEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA- 1434

Query: 767  RCTCAQGYA------------------PAPDGRSCL--------------DVDECE--AG 792
             C C QG +                    P G+  +              D DEC     
Sbjct: 1435 ECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGP 1494

Query: 793  DVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLC 852
             +C NG C NT   + C C  G+H       CED DEC    AC  G+C+NT GS+ C C
Sbjct: 1495 GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ-DLACENGECVNTEGSFHCFC 1553

Query: 853  PQGHRL-VGGRKCQDIDECSQD-------PSLC---LPHGACKN-LQGSYV----CVCDE 896
                 L +  ++C +    ++D         +C   + +  C   L+G       C C +
Sbjct: 1554 SPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQD 1613

Query: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD-HCE 955
            G   +Q    C     P    E Y    +    ++     V  +      G G  D H  
Sbjct: 1614 GEAWSQQCALC-----PPRSSEVYAQLCNVARIEAEREAGVHFRPGY-EYGPGPDDLHYS 1667

Query: 956  IY-----------------PCPVYSSAEFHSL--CPDGKGYTQDNNIVNYGIPAHRD--- 993
            IY                 P P + +   HS    P  +   Q + +  + + +H +   
Sbjct: 1668 IYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPA 1727

Query: 994  ------IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-- 1045
                   +EC +     C+ G+CV  + GY C C +GF  D   + CVDV+EC D +   
Sbjct: 1728 GFEGLQAEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPA 1785

Query: 1046 --CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
              C +G CENT G YRC C+P          C + E
Sbjct: 1786 VLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821



 Score =  134 bits (337), Expect = 5e-31
 Identities = 124/463 (26%), Positives = 183/463 (39%), Gaps = 104/463 (22%)

Query: 254  APSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQ 313
            A  Q +   P   H   PT+     C+       PC S+ L   T Q +CC + G +WG 
Sbjct: 1391 AGGQSMSEAPTGDHAPAPTRMD---CYSGQKGHAPC-SSVLGRNTTQAECCCTQGASWGD 1446

Query: 314  SKCHKCPQ---LQYTGVQKPG----PVRGE--------VGAD---------CPQGYKRLN 349
            + C  CP     +++ +   G    PV G           AD         CP G + LN
Sbjct: 1447 A-CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLN 1504

Query: 350  ST------------------HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            +                    C+D +EC     C +G+C+N  GS+ C C P  +L  S+
Sbjct: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDEC-QDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563

Query: 392  TQCI------ADKPEEK---SLCFRLVSPEHQCQHPLTT-RLTRQLCCCSVGKAWGARCQ 441
             +C+       D P+      +C++ V+ +  C  PL   R T   CCC  G+AW  +C 
Sbjct: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCA 1622

Query: 442  RCPTDGTAAFKEICPAGK-------GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLP 494
             CP   +  + ++C   +       G H    ++      +  +S++  PDG P    L 
Sbjct: 1623 LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIY-GPDGAPFYNYLG 1681

Query: 495  ESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELI-SRPSPPTMRW 553
                    PEDT  E      +  S +R+     P     P+   P  + S P PP    
Sbjct: 1682 --------PEDTVPEPAFPNTAGHSADRTPILESPLQ---PSELQPHYVASHPEPP---- 1726

Query: 554  FLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRY 613
                          A  +  + +EC +  N C +G CV     Y+C C  G++    H  
Sbjct: 1727 --------------AGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771

Query: 614  CVDVNECEAEPCGPG----RGICMNTGGSYNCHCNRGYRLHVG 652
            CVDVNEC+ +  GP      G C NT GSY CHC+ GY    G
Sbjct: 1772 CVDVNECD-DLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAG 1813



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 43/158 (27%), Positives = 53/158 (33%), Gaps = 53/158 (33%)

Query: 1098 DGMCAGPLAGPALTFDDCCCRQGRGWGAQ-CRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1156
            +G CA PL     T +DCC   G  WG   C PC                          
Sbjct: 560  NGQCANPLL-ELTTQEDCCGSVGAFWGVTLCAPC-------------------------- 592

Query: 1157 LGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1216
               PPR      E+                    ECP G++   +   C DI+EC  L  
Sbjct: 593  ---PPRPASPVIENGQ-----------------LECPQGYKR-LNLTHCQDINECLTLG- 630

Query: 1217 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254
               LCK   CVNT GS+ C C+ G         CV  +
Sbjct: 631  ---LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 53/199 (26%), Positives = 67/199 (33%), Gaps = 45/199 (22%)

Query: 112 VCPLPCMNGGQCSSRNQCLCPPDFTGRFCQ--VP--------AGGAGGGTGGSGPGLSRT 161
           VC  PC N G CS    C+C   F G  C+  +P        +  A        P L R+
Sbjct: 190 VCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRS 249

Query: 162 GALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV 221
            A   G L    P                   PP P + PPA   + L    P Q    +
Sbjct: 250 SAAGEGTLARAQPPAPQ--------------SPPAP-QSPPAGTLSGLSQTHPSQQHVGL 294

Query: 222 QAPPPVVNVRVHHPPEASVQVHRIESSNAESAAP-------SQHLLPHPKPSHP----RP 270
                   VR+H    AS Q+    SSNA    P       +Q  +P   PS P      
Sbjct: 295 SR-----TVRLHPTATASSQL----SSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLT 345

Query: 271 PTQKPLGRCFQDTLPKQPC 289
              K +   F  T+ KQ C
Sbjct: 346 EKIKKIKIVFTPTICKQTC 364


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  613 bits (1582), Expect = e-175
 Identities = 445/1407 (31%), Positives = 584/1407 (41%), Gaps = 313/1407 (22%)

Query: 20   AAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKG- 78
            A G+  L + LL+LL  LG +   G  GER             +V F PV+C   C+ G 
Sbjct: 2    AGGVRLLWVSLLVLLAQLGPQPGLGRLGER------------LRVRFTPVVCGLRCVHGP 49

Query: 79   ---QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDF 135
               +C  +C    N T +           G GFR  +CPL C NGG C   ++CLCPPDF
Sbjct: 50   TGSRCTPTCAP-RNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDF 108

Query: 136  TGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPP 195
             G+FCQ+ + GA                                              PP
Sbjct: 109  AGKFCQLHSSGAR---------------------------------------------PP 123

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIES-------- 247
             P   P    + + +PL   +      A   +V+V V HP EASV VH++E         
Sbjct: 124  APAV-PGLTRSVYTMPLANHRDDEHGVAS--MVSVHVEHPQEASVVVHQVERVSGPWEEA 180

Query: 248  -----SNAESAAPSQHLLPHPKPSHPRPPTQ-----KPLGRCFQDTLPKQPCGSNPLPGL 297
                 + AE+AA ++   P+   +   P           G CF++ L    C S PLPGL
Sbjct: 181  DAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRE-LRGGECAS-PLPGL 238

Query: 298  TKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDIN 357
              QE CC   G AWG   C  C +      +   P        CP G++R+N + C+D++
Sbjct: 239  RTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP-----DGPCPTGFERVNGS-CEDVD 292

Query: 358  ECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK--PEEKSLCFRLVSPEHQC 415
            ECA  G C+HG+C N  G Y CVCP G  L  SR+ CI+     E K  CFR++  +  C
Sbjct: 293  ECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR-DGGC 351

Query: 416  QHPLTTRLTRQLCCCS-VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474
              P+   +T+Q+CCCS VGKAWG  CQ CP  G+  F+EICPAG GYH            
Sbjct: 352  SLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHY----------S 401

Query: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534
             SD      P G   P+     P   P            T  P +      +  P     
Sbjct: 402  ASDLRYNTRPLGQEPPRVSLSQPRTLP-----------ATSRPSAGFLPTHRLEPRPEPR 450

Query: 535  P-ARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPG 593
            P  RP PEL   P P    W  P++P S  +          +  C+ N  +CG G C+  
Sbjct: 451  PDPRPGPEL---PLPSIPAWTGPEIPESGPS----------SGMCQRNPQVCGPGRCISR 497

Query: 594  PPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGR---------------------- 629
            P  Y+C C+ G+R  PQ   C+DV+EC     PC PGR                      
Sbjct: 498  PSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRA 557

Query: 630  ------------------GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLC 670
                              G C NT GS+ C C  GY+      G SC D++EC + P LC
Sbjct: 558  AECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ--AAPHGASCQDVDECTQSPGLC 615

Query: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIA 729
            G G  C N PG ++C C  G+R  A      ED+DEC ++P  C  G+C+N  GSF C A
Sbjct: 616  GRGA-CKNLPGSFRCVCPAGFRGSACE----EDVDECAQEPPPCGPGRCDNTAGSFHC-A 669

Query: 730  CQPGYRSQGGGA-CRDVNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVD 787
            C  G+RS+G GA C+DV+ECA    PC+ G CEN  GSF+C C  G+ P   G  C DVD
Sbjct: 670  CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVD 729

Query: 788  ECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIG--GDCINT 844
            ECE    C    C N+PGSFQC+ C SG+HL R R  C D+DEC   A   G  G C NT
Sbjct: 730  ECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNT 787

Query: 845  NGSYRCLCPQGHRLVGGR--KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ 902
             GS+RC C  G+R   GR   C D++EC +    C PHG C N  GS+ C C  G+ P  
Sbjct: 788  EGSFRCSCAPGYRAPSGRPGPCADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGP 846

Query: 903  DQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQ-ECCCSLGAGWGDH----CEIY 957
                C +V+      EC     +   C S + TN     EC C  G   G       ++ 
Sbjct: 847  RGASCLDVD------EC----SEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVD 896

Query: 958  PC----PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--DIDECMLFGSEICKEGKCV 1011
             C    P    ++     P      +D +   +  P     D+DEC  +G EIC   +C 
Sbjct: 897  ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCE 956

Query: 1012 NT----------QPGY---------------------------------ECYCKQGFYYD 1028
            NT           PGY                                 +C C QG+   
Sbjct: 957  NTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016

Query: 1029 GNLLECVDVDECLD-ESNCRNGVCENTRGGYRCAC-TPPAEYSPAQRQCLSPE------- 1079
             +   CVDV+EC   +  C   +CEN  G + C C   P E+ P   +C+ P        
Sbjct: 1017 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFP 1076

Query: 1080 -------------------EMERAPER---------RDVCWSQRGEDGMCAGPLAGPALT 1111
                                + R P           R  C+        C   LA   +T
Sbjct: 1077 GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILA-RNVT 1135

Query: 1112 FDDCCCRQGRGWGAQCRPCPPRGAGSHCP-TSQSESNSFWDTSPLLLGKPPRDEDSSEED 1170
            + +CCC  G GWG+ CR          CP T  +E  S        L   P  + S   D
Sbjct: 1136 WQECCCTVGEGWGSGCRI-------QQCPGTETAEYQSLCPHGRGYLA--PSGDLSLRRD 1186

Query: 1171 SDECR------CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224
             DEC+      C SG CV    G  C C  G+     R  C+D DEC +       C+  
Sbjct: 1187 VDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEP---ACEGG 1243

Query: 1225 RCVNTSGSFRCVCKAGFARSRPHGACV 1251
            RCVNT GS+ C C+           CV
Sbjct: 1244 RCVNTVGSYHCTCEPPLVLDGSQRRCV 1270



 Score =  478 bits (1230), Expect = e-134
 Identities = 330/1006 (32%), Positives = 437/1006 (43%), Gaps = 137/1006 (13%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 381  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 437

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 438  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 489

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 490  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 535

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 536  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 586

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 587  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 636

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 637  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 695

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 696  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 754

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 755  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 810

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 811  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 869

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 870  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 928

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 929  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 986

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 987  RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1043

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1044 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1103

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1104 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1163

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1164 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1219

Query: 1027 YDGNLLECVDVDECLDES-NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAP 1085
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S  E +   
Sbjct: 1220 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLD 1278

Query: 1086 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCP 1131
            +   VCW + G D +C+ P      T+ +CCC  G  WG  C  CP
Sbjct: 1279 DNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1324



 Score =  325 bits (834), Expect = 1e-88
 Identities = 222/624 (35%), Positives = 293/624 (46%), Gaps = 76/624 (12%)

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSF 725
            P +CG G  CI+ P  Y C C  G+RL + +   C D+DECR  P  C  G+CEN PGSF
Sbjct: 486  PQVCGPGR-CISRPSGYTCACDSGFRL-SPQGTRCIDVDECRRVPPPCAPGRCENSPGSF 543

Query: 726  KCIACQPGYRSQGGGA-CRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC 783
            +C+ C PG+R+    A C DV+EC     PC  G CEN PGSF C C  GY  AP G SC
Sbjct: 544  RCV-CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC 602

Query: 784  LDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDC 841
             DVDEC ++  +C  G C N PGSF+C C +G+   R  +  ED+DEC   P  C  G C
Sbjct: 603  QDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRC 659

Query: 842  INTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
             NT GS+ C CP G R  G G  CQD+DEC++ P  C  +G C+N +GS+ CVC  GF P
Sbjct: 660  DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCT-YGRCENTEGSFQCVCPMGFQP 718

Query: 901  TQDQHGCEEVEQPHHKKEC----YLNFDDTVFCDSVLATNVTQQECC-----CSLGAGWG 951
                  CE+V++  +   C     +N   +  C +  + +   +  C     CS GA   
Sbjct: 719  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-- 776

Query: 952  DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR-----DIDECMLFGSEICK 1006
                  PC        H  C + +G  + +    Y  P+ R     D++EC L G     
Sbjct: 777  ------PCGP------HGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 823

Query: 1007 EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA 1066
             G+C+NT   + C C  G+        C+DVDEC +E  C++G+C NT G + C C P  
Sbjct: 824  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 883

Query: 1067 EYSPAQRQCLSPEE-MERAPERRDVCWSQRGEDG----MCA-----GPLAGPALTFDDCC 1116
               P    CL  +E  ER P    +C SQR E+      C      G  AGP  T DD  
Sbjct: 884  RAGPDLASCLDVDECRERGPA---LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV- 939

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
                     +C+   P   G+     ++   S+  T     G  P       +D DECR 
Sbjct: 940  --------DECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGGC-QDVDECRN 988

Query: 1177 VS-----GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1231
             S       C   PG   C C  G++       CVD++EC  L     +C +  C N  G
Sbjct: 989  RSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG---VCGAALCENVEG 1045

Query: 1232 SFRCVCKAGFARSRP-HGACVPQR 1254
            SF CVC        P  G CVP R
Sbjct: 1046 SFLCVCPNSPEEFDPMTGRCVPPR 1069



 Score =  254 bits (650), Expect = 3e-67
 Identities = 285/1095 (26%), Positives = 391/1095 (35%), Gaps = 256/1095 (23%)

Query: 315  KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLN 372
            +CH+ P     G  +  P  G     CP GY+   +   CQD++EC   PG+C  G C N
Sbjct: 565  ECHRVPPPCDLGRCENTP--GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN 622

Query: 373  NPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLC-------------------FRLVSPEH 413
             PGS+RCVCP G   G +  + + +  +E   C                   FR   P  
Sbjct: 623  LPGSFRCVCPAGFR-GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 681

Query: 414  QCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQ 473
             CQ        R    C+ G     RC+   T+G+  F+ +CP G   +   S      +
Sbjct: 682  PCQD--VDECARSPPPCTYG-----RCEN--TEGS--FQCVCPMGFQPNTAGSECEDVDE 730

Query: 474  GESDFSLFLHPDGPPKPQQLPESPSQ---APPPEDTEEERGVTTDSPVSEERSVQQSHPT 530
             E+  +           Q+   SP        P      RG  TD              +
Sbjct: 731  CENHLAC--------PGQECVNSPGSFQCRTCPSGHHLHRGRCTDV----------DECS 772

Query: 531  ATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGEC 590
            +   P  P+    +     T   F     P   A    P    + +EC        HGEC
Sbjct: 773  SGAPPCGPHGHCTN-----TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGEC 827

Query: 591  VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLH 650
            +     ++C C PGYR  P+   C+DV+EC  E      GIC NT GS+ C C  G+R  
Sbjct: 828  LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQS-GICTNTDGSFECICPPGHR-- 884

Query: 651  VGAGGRSCVDLNECAK--PHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDE 706
             G    SC+D++EC +  P LCG    C N PG Y+C  +C PGY   A     C+D+DE
Sbjct: 885  AGPDLASCLDVDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYH--AGPEGTCDDVDE 941

Query: 707  CRD--PSSCPDGKCENKPGSFKCI-ACQPGYRSQGGGACRDVNECAEGSPCS-------- 755
            C++  P  C   +CEN PGS++C  AC PGY+   GG C+DV+EC   S C         
Sbjct: 942  CQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1001

Query: 756  PG-----------------------------------WCENLPGSFRCTC---------- 770
            PG                                    CEN+ GSF C C          
Sbjct: 1002 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1061

Query: 771  ----------------AQGYAPA-----------------------PDG---RSCLDVDE 788
                            +Q  APA                       P G   R C    +
Sbjct: 1062 TGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF--D 1119

Query: 789  CEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN-GS 847
              A D CDN +  N     +C C  G                 + + C    C  T    
Sbjct: 1120 TAAPDACDNILARNVTWQ-ECCCTVGE---------------GWGSGCRIQQCPGTETAE 1163

Query: 848  YRCLCPQGHRLVGGRKC----QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQD 903
            Y+ LCP G   +         +D+DEC          G C N    Y C C  G+     
Sbjct: 1164 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1223

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
            +  C + +      EC    D+   C+           C  ++G+    HC   P  V  
Sbjct: 1224 RLECIDND------ECA---DEEPACEG--------GRCVNTVGSY---HCTCEPPLVLD 1263

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
             ++    C   +  + D+N+         D+         +C   +        EC C  
Sbjct: 1264 GSQRR--CVSNESQSLDDNLGVCWQEVGADL---------VCSHPRLDRQATYTECCCLY 1312

Query: 1024 GFYYDGNLLECVDVDECLDESNCR----NGVCENTRGGYRCACTPPAEYSPA-----QRQ 1074
            G  +  +   C   D    E+ C             GG+      P EY P      Q  
Sbjct: 1313 GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGL----PYEYGPDLGPPYQGL 1368

Query: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134
               PE         D      G       P   P     D     G  +G    P PP G
Sbjct: 1369 PYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-G 1426

Query: 1135 AGSHCP-TSQSESNSFWDTSPLLLGKPPRD--------EDSSEEDSDECR----CVSGRC 1181
             G+  P  S+    SF +       +PP          E   E +++EC     C +GRC
Sbjct: 1427 PGTRWPYRSRDTRRSFPEPE-----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1481

Query: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            V  P G  C C  G++LD +R  CVDI+EC E      LC + RC+NT GSFRC+C+ GF
Sbjct: 1482 VRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541

Query: 1242 ARSRPHGACVPQRRR 1256
            A +     C P R R
Sbjct: 1542 APTHQPHHCAPARPR 1556



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1099 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1148
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 229  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 286

Query: 1149 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1204
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 287  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 328

Query: 1205 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 329  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 382



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1358 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1407

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1408 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1459

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1460 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1516

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1517 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1555


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  588 bits (1517), Expect = e-168
 Identities = 419/1317 (31%), Positives = 549/1317 (41%), Gaps = 296/1317 (22%)

Query: 106  SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALS 165
            +G   V+CPL C NGG C   ++CLCPPDF G+FCQ+ + GA                  
Sbjct: 109  AGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGAR----------------- 151

Query: 166  TGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPP 225
                                        PP P   P    + + +PL   +      A  
Sbjct: 152  ----------------------------PPAPAV-PGLTRSVYTMPLANHRDDEHGVAS- 181

Query: 226  PVVNVRVHHPPEASVQVHRIES-------------SNAESAAPSQHLLPHPKPSHPRPPT 272
             +V+V V HP EASV VH++E              + AE+AA ++   P+   +   P  
Sbjct: 182  -MVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPRE 240

Query: 273  Q-----KPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV 327
                     G CF++ L    C S PLPGL  QE CC   G AWG   C  C +      
Sbjct: 241  DGYSDASGFGYCFRE-LRGGECAS-PLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSE 298

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            +   P        CP G++R+N + C+D++ECA  G C+HG+C N  G Y CVCP G  L
Sbjct: 299  RVSAP-----DGPCPTGFERVNGS-CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 352

Query: 388  GPSRTQCIADK--PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQRCP 444
              SR+ CI+     E K  CFR++  +  C  P+   +T+Q+CCCS VGKAWG  CQ CP
Sbjct: 353  DSSRSSCISQHVISEAKGPCFRVLR-DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 411

Query: 445  TDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPE 504
              G+  F+EICPAG GYH             SD      P G   P+     P   P   
Sbjct: 412  PFGSEGFREICPAGPGYHY----------SASDLRYNTRPLGQEPPRVSLSQPRTLP--- 458

Query: 505  DTEEERGVTTDSPVSEERSVQQSHPTATTTP-ARPYPELISRPSPPTMRWFLPDLPPSRS 563
                     T  P +      +  P     P  RP PEL   P P    W  P++P S  
Sbjct: 459  --------ATSRPSAGFLPTHRLEPRPEPRPDPRPGPEL---PLPSIPAWTGPEIPESGP 507

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE-- 621
            +          +  C+ N  +CG G C+  P  Y+C C+ G+R  PQ   C+DV+EC   
Sbjct: 508  S----------SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 557

Query: 622  AEPCGPGR----------------------------------------GICMNTGGSYNC 641
              PC PGR                                        G C NT GS+ C
Sbjct: 558  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLC 617

Query: 642  HCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
             C  GY+      G SC D++EC + P LCG G  C N PG ++C C  G+R  A     
Sbjct: 618  VCPAGYQ--AAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE--- 671

Query: 701  CEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEG-SPCSPG 757
             ED+DEC ++P  C  G+C+N  GSF C AC  G+RS+G GA C+DV+ECA    PC+ G
Sbjct: 672  -EDVDECAQEPPPCGPGRCDNTAGSFHC-ACPAGFRSRGPGAPCQDVDECARSPPPCTYG 729

Query: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQ-CLSGYH 816
             CEN  GSF+C C  G+ P   G  C DVDECE    C    C N+PGSFQC+ C SG+H
Sbjct: 730  RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 789

Query: 817  LSRDRSHCEDIDECDFPAACIG--GDCINTNGSYRCLCPQGHRLVGGR--KCQDIDECSQ 872
            L R R  C D+DEC   A   G  G C NT GS+RC C  G+R   GR   C D++EC +
Sbjct: 790  LHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE 847

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
                C PHG C N  GS+ C C  G+ P      C +V+      EC     +   C S 
Sbjct: 848  G-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD------EC----SEEDLCQSG 896

Query: 933  LATNVTQQ-ECCCSLGAGWGDH----CEIYPC----PVYSSAEFHSLCPDGKGYTQDNNI 983
            + TN     EC C  G   G       ++  C    P    ++     P      +D + 
Sbjct: 897  ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 956

Query: 984  VNYGIPAHR--DIDECMLFGSEICKEGKCVNT----------QPGY-------------- 1017
              +  P     D+DEC  +G EIC   +C NT           PGY              
Sbjct: 957  GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDEC 1016

Query: 1018 -------------------ECYCKQGFYYDGNLLECVDVDECLD-ESNCRNGVCENTRGG 1057
                               +C C QG+    +   CVDV+EC   +  C   +CEN  G 
Sbjct: 1017 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1076

Query: 1058 YRCAC-TPPAEYSPAQRQCLSPE--------------------------EMERAPER--- 1087
            + C C   P E+ P   +C+ P                            + R P     
Sbjct: 1077 FLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQ 1136

Query: 1088 ------RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP- 1140
                  R  C+        C   LA   +T+ +CCC  G GWG+ CR          CP 
Sbjct: 1137 GPVGSGRRECYFDTAAPDACDNILA-RNVTWQECCCTVGEGWGSGCRI-------QQCPG 1188

Query: 1141 TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRCVPRPGGAVCECPG 1194
            T  +E  S        L   P  + S   D DEC+      C SG CV    G  C C  
Sbjct: 1189 TETAEYQSLCPHGRGYLA--PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1246

Query: 1195 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
            G+     R  C+D DEC +       C+  RCVNT GS+ C C+           CV
Sbjct: 1247 GYYYHTQRLECIDNDECADEEP---ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1300



 Score =  478 bits (1230), Expect = e-134
 Identities = 330/1006 (32%), Positives = 437/1006 (43%), Gaps = 137/1006 (13%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 411  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 467

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 468  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 519

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 520  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 565

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 566  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 616

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 617  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 666

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 667  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 725

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 726  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 784

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 785  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 840

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 841  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 899

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 900  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 958

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 959  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 1016

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 1017 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1073

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1074 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1133

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1134 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1193

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1194 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1249

Query: 1027 YDGNLLECVDVDECLDES-NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAP 1085
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S  E +   
Sbjct: 1250 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLD 1308

Query: 1086 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCP 1131
            +   VCW + G D +C+ P      T+ +CCC  G  WG  C  CP
Sbjct: 1309 DNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1354



 Score =  325 bits (834), Expect = 1e-88
 Identities = 222/624 (35%), Positives = 293/624 (46%), Gaps = 76/624 (12%)

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSF 725
            P +CG G  CI+ P  Y C C  G+RL + +   C D+DECR  P  C  G+CEN PGSF
Sbjct: 516  PQVCGPGR-CISRPSGYTCACDSGFRL-SPQGTRCIDVDECRRVPPPCAPGRCENSPGSF 573

Query: 726  KCIACQPGYRSQGGGA-CRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC 783
            +C+ C PG+R+    A C DV+EC     PC  G CEN PGSF C C  GY  AP G SC
Sbjct: 574  RCV-CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC 632

Query: 784  LDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDC 841
             DVDEC ++  +C  G C N PGSF+C C +G+   R  +  ED+DEC   P  C  G C
Sbjct: 633  QDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRC 689

Query: 842  INTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
             NT GS+ C CP G R  G G  CQD+DEC++ P  C  +G C+N +GS+ CVC  GF P
Sbjct: 690  DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCT-YGRCENTEGSFQCVCPMGFQP 748

Query: 901  TQDQHGCEEVEQPHHKKEC----YLNFDDTVFCDSVLATNVTQQECC-----CSLGAGWG 951
                  CE+V++  +   C     +N   +  C +  + +   +  C     CS GA   
Sbjct: 749  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-- 806

Query: 952  DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR-----DIDECMLFGSEICK 1006
                  PC        H  C + +G  + +    Y  P+ R     D++EC L G     
Sbjct: 807  ------PCGP------HGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 853

Query: 1007 EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA 1066
             G+C+NT   + C C  G+        C+DVDEC +E  C++G+C NT G + C C P  
Sbjct: 854  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 913

Query: 1067 EYSPAQRQCLSPEE-MERAPERRDVCWSQRGEDG----MCA-----GPLAGPALTFDDCC 1116
               P    CL  +E  ER P    +C SQR E+      C      G  AGP  T DD  
Sbjct: 914  RAGPDLASCLDVDECRERGPA---LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV- 969

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
                     +C+   P   G+     ++   S+  T     G  P       +D DECR 
Sbjct: 970  --------DECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGGC-QDVDECRN 1018

Query: 1177 VS-----GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1231
             S       C   PG   C C  G++       CVD++EC  L     +C +  C N  G
Sbjct: 1019 RSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG---VCGAALCENVEG 1075

Query: 1232 SFRCVCKAGFARSRP-HGACVPQR 1254
            SF CVC        P  G CVP R
Sbjct: 1076 SFLCVCPNSPEEFDPMTGRCVPPR 1099



 Score =  254 bits (650), Expect = 3e-67
 Identities = 285/1095 (26%), Positives = 391/1095 (35%), Gaps = 256/1095 (23%)

Query: 315  KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLN 372
            +CH+ P     G  +  P  G     CP GY+   +   CQD++EC   PG+C  G C N
Sbjct: 595  ECHRVPPPCDLGRCENTP--GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN 652

Query: 373  NPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLC-------------------FRLVSPEH 413
             PGS+RCVCP G   G +  + + +  +E   C                   FR   P  
Sbjct: 653  LPGSFRCVCPAGFR-GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 711

Query: 414  QCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQ 473
             CQ        R    C+ G     RC+   T+G+  F+ +CP G   +   S      +
Sbjct: 712  PCQD--VDECARSPPPCTYG-----RCEN--TEGS--FQCVCPMGFQPNTAGSECEDVDE 760

Query: 474  GESDFSLFLHPDGPPKPQQLPESPSQ---APPPEDTEEERGVTTDSPVSEERSVQQSHPT 530
             E+  +           Q+   SP        P      RG  TD              +
Sbjct: 761  CENHLAC--------PGQECVNSPGSFQCRTCPSGHHLHRGRCTDV----------DECS 802

Query: 531  ATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGEC 590
            +   P  P+    +     T   F     P   A    P    + +EC        HGEC
Sbjct: 803  SGAPPCGPHGHCTN-----TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGEC 857

Query: 591  VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLH 650
            +     ++C C PGYR  P+   C+DV+EC  E      GIC NT GS+ C C  G+R  
Sbjct: 858  LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQS-GICTNTDGSFECICPPGHR-- 914

Query: 651  VGAGGRSCVDLNECAK--PHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDE 706
             G    SC+D++EC +  P LCG    C N PG Y+C  +C PGY   A     C+D+DE
Sbjct: 915  AGPDLASCLDVDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYH--AGPEGTCDDVDE 971

Query: 707  CRD--PSSCPDGKCENKPGSFKCI-ACQPGYRSQGGGACRDVNECAEGSPCS-------- 755
            C++  P  C   +CEN PGS++C  AC PGY+   GG C+DV+EC   S C         
Sbjct: 972  CQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1031

Query: 756  PG-----------------------------------WCENLPGSFRCTC---------- 770
            PG                                    CEN+ GSF C C          
Sbjct: 1032 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1091

Query: 771  ----------------AQGYAPA-----------------------PDG---RSCLDVDE 788
                            +Q  APA                       P G   R C    +
Sbjct: 1092 TGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF--D 1149

Query: 789  CEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN-GS 847
              A D CDN +  N     +C C  G                 + + C    C  T    
Sbjct: 1150 TAAPDACDNILARNVTWQ-ECCCTVGE---------------GWGSGCRIQQCPGTETAE 1193

Query: 848  YRCLCPQGHRLVGGRKC----QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQD 903
            Y+ LCP G   +         +D+DEC          G C N    Y C C  G+     
Sbjct: 1194 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1253

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
            +  C + +      EC    D+   C+           C  ++G+    HC   P  V  
Sbjct: 1254 RLECIDND------ECA---DEEPACEG--------GRCVNTVGSY---HCTCEPPLVLD 1293

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
             ++    C   +  + D+N+         D+         +C   +        EC C  
Sbjct: 1294 GSQRR--CVSNESQSLDDNLGVCWQEVGADL---------VCSHPRLDRQATYTECCCLY 1342

Query: 1024 GFYYDGNLLECVDVDECLDESNCR----NGVCENTRGGYRCACTPPAEYSPA-----QRQ 1074
            G  +  +   C   D    E+ C             GG+      P EY P      Q  
Sbjct: 1343 GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGL----PYEYGPDLGPPYQGL 1398

Query: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134
               PE         D      G       P   P     D     G  +G    P PP G
Sbjct: 1399 PYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-G 1456

Query: 1135 AGSHCP-TSQSESNSFWDTSPLLLGKPPRD--------EDSSEEDSDECR----CVSGRC 1181
             G+  P  S+    SF +       +PP          E   E +++EC     C +GRC
Sbjct: 1457 PGTRWPYRSRDTRRSFPEPE-----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1511

Query: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            V  P G  C C  G++LD +R  CVDI+EC E      LC + RC+NT GSFRC+C+ GF
Sbjct: 1512 VRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571

Query: 1242 ARSRPHGACVPQRRR 1256
            A +     C P R R
Sbjct: 1572 APTHQPHHCAPARPR 1586



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1099 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1148
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 259  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 316

Query: 1149 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1204
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 317  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 358

Query: 1205 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 359  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 412



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1388 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1437

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1438 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1489

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1490 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1546

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1547 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1585


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  588 bits (1517), Expect = e-168
 Identities = 419/1317 (31%), Positives = 549/1317 (41%), Gaps = 296/1317 (22%)

Query: 106  SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALS 165
            +G   V+CPL C NGG C   ++CLCPPDF G+FCQ+ + GA                  
Sbjct: 146  AGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGAR----------------- 188

Query: 166  TGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPP 225
                                        PP P   P    + + +PL   +      A  
Sbjct: 189  ----------------------------PPAPAV-PGLTRSVYTMPLANHRDDEHGVAS- 218

Query: 226  PVVNVRVHHPPEASVQVHRIES-------------SNAESAAPSQHLLPHPKPSHPRPPT 272
             +V+V V HP EASV VH++E              + AE+AA ++   P+   +   P  
Sbjct: 219  -MVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPRE 277

Query: 273  Q-----KPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV 327
                     G CF++ L    C S PLPGL  QE CC   G AWG   C  C +      
Sbjct: 278  DGYSDASGFGYCFRE-LRGGECAS-PLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSE 335

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            +   P        CP G++R+N + C+D++ECA  G C+HG+C N  G Y CVCP G  L
Sbjct: 336  RVSAP-----DGPCPTGFERVNGS-CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 389

Query: 388  GPSRTQCIADK--PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQRCP 444
              SR+ CI+     E K  CFR++  +  C  P+   +T+Q+CCCS VGKAWG  CQ CP
Sbjct: 390  DSSRSSCISQHVISEAKGPCFRVLR-DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 448

Query: 445  TDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPE 504
              G+  F+EICPAG GYH             SD      P G   P+     P   P   
Sbjct: 449  PFGSEGFREICPAGPGYHY----------SASDLRYNTRPLGQEPPRVSLSQPRTLP--- 495

Query: 505  DTEEERGVTTDSPVSEERSVQQSHPTATTTP-ARPYPELISRPSPPTMRWFLPDLPPSRS 563
                     T  P +      +  P     P  RP PEL   P P    W  P++P S  
Sbjct: 496  --------ATSRPSAGFLPTHRLEPRPEPRPDPRPGPEL---PLPSIPAWTGPEIPESGP 544

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE-- 621
            +          +  C+ N  +CG G C+  P  Y+C C+ G+R  PQ   C+DV+EC   
Sbjct: 545  S----------SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 594

Query: 622  AEPCGPGR----------------------------------------GICMNTGGSYNC 641
              PC PGR                                        G C NT GS+ C
Sbjct: 595  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLC 654

Query: 642  HCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
             C  GY+      G SC D++EC + P LCG G  C N PG ++C C  G+R  A     
Sbjct: 655  VCPAGYQ--AAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE--- 708

Query: 701  CEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEG-SPCSPG 757
             ED+DEC ++P  C  G+C+N  GSF C AC  G+RS+G GA C+DV+ECA    PC+ G
Sbjct: 709  -EDVDECAQEPPPCGPGRCDNTAGSFHC-ACPAGFRSRGPGAPCQDVDECARSPPPCTYG 766

Query: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQ-CLSGYH 816
             CEN  GSF+C C  G+ P   G  C DVDECE    C    C N+PGSFQC+ C SG+H
Sbjct: 767  RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 826

Query: 817  LSRDRSHCEDIDECDFPAACIG--GDCINTNGSYRCLCPQGHRLVGGR--KCQDIDECSQ 872
            L R R  C D+DEC   A   G  G C NT GS+RC C  G+R   GR   C D++EC +
Sbjct: 827  LHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE 884

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
                C PHG C N  GS+ C C  G+ P      C +V+      EC     +   C S 
Sbjct: 885  G-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD------EC----SEEDLCQSG 933

Query: 933  LATNVTQQ-ECCCSLGAGWGDH----CEIYPC----PVYSSAEFHSLCPDGKGYTQDNNI 983
            + TN     EC C  G   G       ++  C    P    ++     P      +D + 
Sbjct: 934  ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 993

Query: 984  VNYGIPAHR--DIDECMLFGSEICKEGKCVNT----------QPGY-------------- 1017
              +  P     D+DEC  +G EIC   +C NT           PGY              
Sbjct: 994  GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDEC 1053

Query: 1018 -------------------ECYCKQGFYYDGNLLECVDVDECLD-ESNCRNGVCENTRGG 1057
                               +C C QG+    +   CVDV+EC   +  C   +CEN  G 
Sbjct: 1054 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1113

Query: 1058 YRCAC-TPPAEYSPAQRQCLSPE--------------------------EMERAPER--- 1087
            + C C   P E+ P   +C+ P                            + R P     
Sbjct: 1114 FLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQ 1173

Query: 1088 ------RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP- 1140
                  R  C+        C   LA   +T+ +CCC  G GWG+ CR          CP 
Sbjct: 1174 GPVGSGRRECYFDTAAPDACDNILA-RNVTWQECCCTVGEGWGSGCRI-------QQCPG 1225

Query: 1141 TSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRCVPRPGGAVCECPG 1194
            T  +E  S        L   P  + S   D DEC+      C SG CV    G  C C  
Sbjct: 1226 TETAEYQSLCPHGRGYLA--PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1283

Query: 1195 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
            G+     R  C+D DEC +       C+  RCVNT GS+ C C+           CV
Sbjct: 1284 GYYYHTQRLECIDNDECADEEP---ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1337



 Score =  478 bits (1230), Expect = e-134
 Identities = 330/1006 (32%), Positives = 437/1006 (43%), Gaps = 137/1006 (13%)

Query: 201  PPAQHAAF--LVPLGPGQISAEVQAPPPVVNVRV--HHPPEASVQVHRIESSNAESAA-- 254
            PP     F  + P GPG       A     N R     PP  S+   R   + +  +A  
Sbjct: 448  PPFGSEGFREICPAGPGY---HYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 504

Query: 255  -PSQHLLPHPKPS-HPRPPTQKPLGRCFQDTLPKQPCGSNP-LPGLTKQEDCCGSIGTAW 311
             P+  L P P+P   PRP  + PL        P  P  + P +P        C       
Sbjct: 505  LPTHRLEPRPEPRPDPRPGPELPL--------PSIPAWTGPEIPESGPSSGMCQRNPQVC 556

Query: 312  GQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECA-MPGVCRHGD 369
            G  +C   P   YT               C  G++     T C D++EC  +P  C  G 
Sbjct: 557  GPGRCISRPS-GYT-------------CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR 602

Query: 370  CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH--QCQHPLTTRLTRQL 427
            C N+PGS+RCVC PG   GP   +C+     +   C R+  P    +C++   + L    
Sbjct: 603  CENSPGSFRCVCGPGFRAGPRAAECL-----DVDECHRVPPPCDLGRCENTPGSFL---- 653

Query: 428  CCCSVG---KAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHP 484
            C C  G      GA CQ    D       +C  G   ++  S + +   G          
Sbjct: 654  CVCPAGYQAAPHGASCQ--DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR-------- 703

Query: 485  DGPPKPQQLPESPSQAPP--PEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             G    + + E   + PP  P   +   G    +  +  RS     P          P  
Sbjct: 704  -GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPP 762

Query: 543  ISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCN 602
             +             + P       A ++  + DEC  N   C   ECV  P  + C   
Sbjct: 763  CTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQCRTC 821

Query: 603  PGYRSHPQHR-YCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCV 659
            P    H  HR  C DV+EC   A PCGP  G C NT GS+ C C  GYR   G  G  C 
Sbjct: 822  PS--GHHLHRGRCTDVDECSSGAPPCGP-HGHCTNTEGSFRCSCAPGYRAPSGRPG-PCA 877

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
            D+NEC +   C   G C+N  G + C C PGYR    R   C D+DEC +   C  G C 
Sbjct: 878  DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLDVDECSEEDLCQSGICT 936

Query: 720  NKPGSFKCIACQPGYRSQGG-GACRDVNECAEGSP--CSPGWCENLPGSFRCT--CAQGY 774
            N  GSF+CI C PG+R+     +C DV+EC E  P  C    CEN PGS+RC   C  GY
Sbjct: 937  NTDGSFECI-CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 995

Query: 775  APAPDGRSCLDVDECE--AGDVCDNGICSNTPGSFQCQ--CLSGYHLSRDRSHCEDIDEC 830
               P+G +C DVDEC+    ++C    C NTPGS++C   C  GY  +     C+D+DEC
Sbjct: 996  HAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDVDEC 1053

Query: 831  DFPAAC-IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA--CKNL 886
               + C     C N  GS++CLC QG+     GR C D++EC     +C   GA  C+N+
Sbjct: 1054 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC---GAALCENV 1110

Query: 887  QGSYVCVCDEG----------FTPTQDQHGCEEVEQPHH--------------------- 915
            +GS++CVC               P +   G     QP                       
Sbjct: 1111 EGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1170

Query: 916  ---------KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
                     ++ECY +      CD++LA NVT QECCC++G GWG  C I  CP   +AE
Sbjct: 1171 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1230

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            + SLCP G+GY   +      +   RD+DEC LF  ++CK G CVNT PGY CYC  G+Y
Sbjct: 1231 YQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1286

Query: 1027 YDGNLLECVDVDECLDES-NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAP 1085
            Y    LEC+D DEC DE   C  G C NT G Y C C PP     +QR+C+S  E +   
Sbjct: 1287 YHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLD 1345

Query: 1086 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCP 1131
            +   VCW + G D +C+ P      T+ +CCC  G  WG  C  CP
Sbjct: 1346 DNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1391



 Score =  325 bits (834), Expect = 1e-88
 Identities = 222/624 (35%), Positives = 293/624 (46%), Gaps = 76/624 (12%)

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSF 725
            P +CG G  CI+ P  Y C C  G+RL + +   C D+DECR  P  C  G+CEN PGSF
Sbjct: 553  PQVCGPGR-CISRPSGYTCACDSGFRL-SPQGTRCIDVDECRRVPPPCAPGRCENSPGSF 610

Query: 726  KCIACQPGYRSQGGGA-CRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC 783
            +C+ C PG+R+    A C DV+EC     PC  G CEN PGSF C C  GY  AP G SC
Sbjct: 611  RCV-CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC 669

Query: 784  LDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDC 841
             DVDEC ++  +C  G C N PGSF+C C +G+   R  +  ED+DEC   P  C  G C
Sbjct: 670  QDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRC 726

Query: 842  INTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP 900
             NT GS+ C CP G R  G G  CQD+DEC++ P  C  +G C+N +GS+ CVC  GF P
Sbjct: 727  DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCT-YGRCENTEGSFQCVCPMGFQP 785

Query: 901  TQDQHGCEEVEQPHHKKEC----YLNFDDTVFCDSVLATNVTQQECC-----CSLGAGWG 951
                  CE+V++  +   C     +N   +  C +  + +   +  C     CS GA   
Sbjct: 786  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-- 843

Query: 952  DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR-----DIDECMLFGSEICK 1006
                  PC        H  C + +G  + +    Y  P+ R     D++EC L G     
Sbjct: 844  ------PCGP------HGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 890

Query: 1007 EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA 1066
             G+C+NT   + C C  G+        C+DVDEC +E  C++G+C NT G + C C P  
Sbjct: 891  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 950

Query: 1067 EYSPAQRQCLSPEE-MERAPERRDVCWSQRGEDG----MCA-----GPLAGPALTFDDCC 1116
               P    CL  +E  ER P    +C SQR E+      C      G  AGP  T DD  
Sbjct: 951  RAGPDLASCLDVDECRERGPA---LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV- 1006

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
                     +C+   P   G+     ++   S+  T     G  P       +D DECR 
Sbjct: 1007 --------DECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGGC-QDVDECRN 1055

Query: 1177 VS-----GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1231
             S       C   PG   C C  G++       CVD++EC  L     +C +  C N  G
Sbjct: 1056 RSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG---VCGAALCENVEG 1112

Query: 1232 SFRCVCKAGFARSRP-HGACVPQR 1254
            SF CVC        P  G CVP R
Sbjct: 1113 SFLCVCPNSPEEFDPMTGRCVPPR 1136



 Score =  254 bits (650), Expect = 3e-67
 Identities = 285/1095 (26%), Positives = 391/1095 (35%), Gaps = 256/1095 (23%)

Query: 315  KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLN 372
            +CH+ P     G  +  P  G     CP GY+   +   CQD++EC   PG+C  G C N
Sbjct: 632  ECHRVPPPCDLGRCENTP--GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN 689

Query: 373  NPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLC-------------------FRLVSPEH 413
             PGS+RCVCP G   G +  + + +  +E   C                   FR   P  
Sbjct: 690  LPGSFRCVCPAGFR-GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 748

Query: 414  QCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQ 473
             CQ        R    C+ G     RC+   T+G+  F+ +CP G   +   S      +
Sbjct: 749  PCQD--VDECARSPPPCTYG-----RCEN--TEGS--FQCVCPMGFQPNTAGSECEDVDE 797

Query: 474  GESDFSLFLHPDGPPKPQQLPESPSQ---APPPEDTEEERGVTTDSPVSEERSVQQSHPT 530
             E+  +           Q+   SP        P      RG  TD              +
Sbjct: 798  CENHLAC--------PGQECVNSPGSFQCRTCPSGHHLHRGRCTDV----------DECS 839

Query: 531  ATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGEC 590
            +   P  P+    +     T   F     P   A    P    + +EC        HGEC
Sbjct: 840  SGAPPCGPHGHCTN-----TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGEC 894

Query: 591  VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLH 650
            +     ++C C PGYR  P+   C+DV+EC  E      GIC NT GS+ C C  G+R  
Sbjct: 895  LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQS-GICTNTDGSFECICPPGHR-- 951

Query: 651  VGAGGRSCVDLNECAK--PHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDE 706
             G    SC+D++EC +  P LCG    C N PG Y+C  +C PGY   A     C+D+DE
Sbjct: 952  AGPDLASCLDVDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYH--AGPEGTCDDVDE 1008

Query: 707  CRD--PSSCPDGKCENKPGSFKCI-ACQPGYRSQGGGACRDVNECAEGSPCS-------- 755
            C++  P  C   +CEN PGS++C  AC PGY+   GG C+DV+EC   S C         
Sbjct: 1009 CQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1068

Query: 756  PG-----------------------------------WCENLPGSFRCTC---------- 770
            PG                                    CEN+ GSF C C          
Sbjct: 1069 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1128

Query: 771  ----------------AQGYAPA-----------------------PDG---RSCLDVDE 788
                            +Q  APA                       P G   R C    +
Sbjct: 1129 TGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF--D 1186

Query: 789  CEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN-GS 847
              A D CDN +  N     +C C  G                 + + C    C  T    
Sbjct: 1187 TAAPDACDNILARNVTWQ-ECCCTVGE---------------GWGSGCRIQQCPGTETAE 1230

Query: 848  YRCLCPQGHRLVGGRKC----QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQD 903
            Y+ LCP G   +         +D+DEC          G C N    Y C C  G+     
Sbjct: 1231 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1290

Query: 904  QHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS 963
            +  C + +      EC    D+   C+           C  ++G+    HC   P  V  
Sbjct: 1291 RLECIDND------ECA---DEEPACEG--------GRCVNTVGSY---HCTCEPPLVLD 1330

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
             ++    C   +  + D+N+         D+         +C   +        EC C  
Sbjct: 1331 GSQRR--CVSNESQSLDDNLGVCWQEVGADL---------VCSHPRLDRQATYTECCCLY 1379

Query: 1024 GFYYDGNLLECVDVDECLDESNCR----NGVCENTRGGYRCACTPPAEYSPA-----QRQ 1074
            G  +  +   C   D    E+ C             GG+      P EY P      Q  
Sbjct: 1380 GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGL----PYEYGPDLGPPYQGL 1435

Query: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134
               PE         D      G       P   P     D     G  +G    P PP G
Sbjct: 1436 PYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE-DDGGPYGESEAPAPP-G 1493

Query: 1135 AGSHCP-TSQSESNSFWDTSPLLLGKPPRD--------EDSSEEDSDECR----CVSGRC 1181
             G+  P  S+    SF +       +PP          E   E +++EC     C +GRC
Sbjct: 1494 PGTRWPYRSRDTRRSFPEPE-----EPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1548

Query: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            V  P G  C C  G++LD +R  CVDI+EC E      LC + RC+NT GSFRC+C+ GF
Sbjct: 1549 VRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608

Query: 1242 ARSRPHGACVPQRRR 1256
            A +     C P R R
Sbjct: 1609 APTHQPHHCAPARPR 1623



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 56/176 (31%), Positives = 63/176 (35%), Gaps = 44/176 (25%)

Query: 1099 GMCAGPLAGPALTFDDCCCR-QGRGWGAQ-CRPCPPRGAGSH--------CPTSQSESNS 1148
            G CA PL  P L   + CCR  G  WG   C+ C  R   S         CPT     N 
Sbjct: 296  GECASPL--PGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNG 353

Query: 1149 FWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRAR 1204
                              S ED DEC    RC  G C    GG  C CP GF LD+SR+ 
Sbjct: 354  ------------------SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSS 395

Query: 1205 CVD---IDEC-----RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            C+    I E      R L   G  C      N +    C  + G A  R    C P
Sbjct: 396  CISQHVISEAKGPCFRVLRDGG--CSLPILRNITKQICCCSRVGKAWGRGCQLCPP 449



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/219 (28%), Positives = 82/219 (37%), Gaps = 36/219 (16%)

Query: 196  GPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPP-------EASVQVHRIESS 248
            GP  GPP Q     +P GP         PPP +    + PP       EA     R +  
Sbjct: 1425 GPDLGPPYQG----LPYGPELY------PPPALPYDPYPPPPGPFARREAPYGAPRFDMP 1474

Query: 249  NAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIG 308
            + E           P P  P P T+ P     +DT    P    P  G        GS+ 
Sbjct: 1475 DFEDDGGPYGESEAPAP--PGPGTRWPYRS--RDTRRSFPEPEEPPEG----GSYAGSLA 1526

Query: 309  TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP--QGYKRLNSTH--CQDINEC----A 360
              + + +  +C  L   G      VR   G  C    GY RL+ T   C DINEC    A
Sbjct: 1527 EPYEELEAEECGILD--GCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEA 1583

Query: 361  MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
               +C +  CLN  GS+RC+C PG +       C   +P
Sbjct: 1584 ASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARP 1622


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  451 bits (1160), Expect = e-126
 Identities = 312/969 (32%), Positives = 418/969 (43%), Gaps = 111/969 (11%)

Query: 335  GEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            G     CP G+     T  C+D++EC +   C  G C N  GSY C C PG  L PS T 
Sbjct: 745  GSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803

Query: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA--- 450
            C+      K  C+  +  E +C+  L     R  CC ++G AWG+ C+RC  D   A   
Sbjct: 804  CL---DSTKGTCWLKIQ-ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF 859

Query: 451  ----------------FKEICPAGKGYHILTSHQTLTIQGES-DFSLFLHPDGPPKPQQL 493
                            F  +CP G+  +   S +    +G   D S  L  D   +P  L
Sbjct: 860  ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL 919

Query: 494  PESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPT-ATTTPARPYPELISRPS--PPT 550
                         E+E GVT       +               A P PE +   S  P  
Sbjct: 920  RWD----------EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969

Query: 551  MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQ 610
            + +   D    R   +       + +EC++   +C HG C      + C C  G+    Q
Sbjct: 970  LGFASRDFLSGRPFYK-------DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022

Query: 611  HRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLC 670
             R C D++EC   P   G+G C+NT GS+ C C  GY        ++C+D++ECA+  L 
Sbjct: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML-MKNCMDVDECARDPLL 1081

Query: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIA 729
              GG C N  G YKC C PG+ L A +   CEDIDEC      CP G+C N  G+F+C +
Sbjct: 1082 CRGGTCTNTDGSYKCQCPPGHELTA-KGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-S 1139

Query: 730  CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788
            C  G++S      C D+NEC   +      C N  GS+RC+C QGY+  PDGR+C DVDE
Sbjct: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDE 1199

Query: 789  CEAGD-VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNG 846
            CE    VCD G C+N PG  +C C  G+  + D   C D+DECD  P  C+ GDC NT G
Sbjct: 1200 CEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKG 1259

Query: 847  SYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ-DQ 904
            S+ C C  G+ +  G   C D+DEC      C  H +C N+ GS+ C C  G+     + 
Sbjct: 1260 SFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG-AGWGDHCEIYPCPVYS 963
            H  +E     H+  C    D    C +V  +      C C  G AG G  CE        
Sbjct: 1320 HDLDECVSQEHR--CSPRGD----CLNVPGS----YRCTCRQGFAGDGFFCEDRD----E 1365

Query: 964  SAEFHSLCPDGK------GYTQDNNIVNYGIPAHR---DIDECMLFGSEICKEGKCVNTQ 1014
             AE   LC +G+      GY  +  +       HR   D+DEC      +C  G C N  
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECA--QGNLCAFGSCENLP 1423

Query: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
              + C C  G+  D     C D++EC D  NC NGVC NT G Y C+C    E +P+   
Sbjct: 1424 GMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVG 1483

Query: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134
            C+         E  D     RG+ G+      G  +T   CCC  GR WG  C  CP   
Sbjct: 1484 CVDTRAGNCFLETHD-----RGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMAN 1538

Query: 1135 AGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPG 1186
               +   CP  +              G  P       ED DEC+     C  G CV   G
Sbjct: 1539 TTEYRTLCPGGE--------------GFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584

Query: 1187 GAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRP 1246
               CECP G+ L      C DIDEC   +    +C    C NT G++ CVC A + +   
Sbjct: 1585 SFQCECPPGYHLSEHTRICEDIDEC---STHSGICGPGTCYNTLGNYTCVCPAEYLQVNG 1641

Query: 1247 HGACVPQRR 1255
               C+  R+
Sbjct: 1642 GNNCMDMRK 1650



 Score =  437 bits (1123), Expect = e-122
 Identities = 266/741 (35%), Positives = 359/741 (48%), Gaps = 104/741 (14%)

Query: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
            T   + DEC L+  +C HG+CV     + C C+ G++S P  + CVD+NEC  +  G   
Sbjct: 1109 TACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDV 1168

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCY 688
              C+NT GSY C C +GY L     GR+C D++EC + P +C D G C N PG ++C CY
Sbjct: 1169 H-CINTEGSYRCSCGQGYSLM--PDGRACADVDECEENPRVC-DQGHCTNMPGGHRCLCY 1224

Query: 689  PGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVN 746
             G+ +       C D+DEC  +P  C  G CEN  GSF C  CQ GY   +G   C DV+
Sbjct: 1225 DGF-MATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVC-HCQLGYMVRKGATGCSDVD 1282

Query: 747  ECAEGSP------------------CSPGW-------------------------CENLP 763
            EC  G                    C PGW                         C N+P
Sbjct: 1283 ECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVP 1342

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
            GS+RCTC QG+A   DG  C D DEC E  D+CDNG C N PG ++C+C  G+  + D  
Sbjct: 1343 GSYRCTCRQGFAG--DGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHR 1400

Query: 823  HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHG 881
             C+D+DEC     C  G C N  G +RC+C  G+ L  GG  C DI+EC+ DP  C+ +G
Sbjct: 1401 ACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVNCI-NG 1458

Query: 882  ACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQE 941
             C N  GSY+C C + F       GC +    +   E +   D  + C + +   VT+  
Sbjct: 1459 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS 1518

Query: 942  CCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001
            CCCSLG  WG+ CE+  CP+ ++ E+ +LCP G+G+ Q N I         DIDEC    
Sbjct: 1519 CCCSLGRAWGNPCEL--CPMANTTEYRTLCPGGEGF-QPNRIT----VILEDIDECQELP 1571

Query: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRC 1060
              +C+ G CVNT   ++C C  G++   +   C D+DEC   S  C  G C NT G Y C
Sbjct: 1572 G-LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTC 1630

Query: 1061 ACTPPAEYSPAQ--RQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCR 1118
             C  PAEY        C+          R+ VC+  R  +G C   LA   +T   CCC 
Sbjct: 1631 VC--PAEYLQVNGGNNCMDM--------RKSVCF--RHYNGTCQNELAFN-VTRKMCCCS 1677

Query: 1119 Q--GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR- 1175
               G+ W   C  CP   +  +     +++  F   + +  GKP         D DEC  
Sbjct: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGF--LTDIHTGKPL--------DIDECGE 1727

Query: 1176 ----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSER-CVNTS 1230
                C +G C+ + G   CECP GF  ++    C D+DEC     R   C+    C+N  
Sbjct: 1728 IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC---GSRESPCQQNADCINIP 1784

Query: 1231 GSFRCVCKAGFARSRPHGACV 1251
            GS+RC C  G+  S P GACV
Sbjct: 1785 GSYRCKCTRGYKLS-PGGACV 1804



 Score =  409 bits (1052), Expect = e-114
 Identities = 332/1151 (28%), Positives = 447/1151 (38%), Gaps = 252/1151 (21%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQED-CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335
            G CF    P + C  + L GL   +  CC ++G AWG   C  CP        +P P   
Sbjct: 185  GPCFGQVGP-EGC-QHQLTGLVCTKALCCATVGRAWGLP-CELCPA-------QPHP--- 231

Query: 336  EVGADCPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
                 C +G+   +++  CQD++EC A+PG+C+ G C+N  GS+ C CP GH L  S   
Sbjct: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286

Query: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAAF 451
            C   +      CF ++    +C   L    TR+ CCC  G+ W A    + CP  G+  F
Sbjct: 287  C---EDYRAGACFSVLFGG-RCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEF 342

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
            +++C   +   +L  H  L   G   F    +  GPP        P++  P     + RG
Sbjct: 343  QQLC--AQRLPLLPGHPGL-FPGLLGFGS--NGMGPPL------GPARLNP--HGSDARG 389

Query: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQ 571
            + +  P +   ++  +    T    R +  L            LP     R    +  TQ
Sbjct: 390  IPSLGPGNS--NIGTATLNQTIDICRHFTNLCLNGR------CLPTPSSYRCECNVGYTQ 441

Query: 572  -----VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCG 626
                   + DEC    + C HG+CV  P  Y C C PG+++ P  + CVDV+EC      
Sbjct: 442  DVRGECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499

Query: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686
               G C+NT GS+ C CN G+ L     G++CVD NECA   +C + G C+N  G + C 
Sbjct: 500  CHLGRCVNTEGSFQCVCNAGFEL--SPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCL 556

Query: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745
            C PG+ L A     C DIDEC+ P  C +G C N  GSF+C  C  G      G  C D 
Sbjct: 557  CKPGF-LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLGGLAVGTDGRVCVDT 614

Query: 746  N------------ECAE--------------------GSPC------------------- 754
            +             CA                     G PC                   
Sbjct: 615  HVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGL 674

Query: 755  --------------SPGWCEN-----LPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-V 794
                           P  C N     L GS+RC C  GY     G+ C DVDEC     +
Sbjct: 675  GITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLL 734

Query: 795  CDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQ 854
            CDNG C N+PGS+ C C  G+H  +D   C+D+DEC   + C+ G C N  GSY C C  
Sbjct: 735  CDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGP 793

Query: 855  GHRL-VGGRKCQD---------------------------------------IDECSQDP 874
            G RL   G  C D                                        + C  DP
Sbjct: 794  GSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDP 853

Query: 875  SLCLPH------------------GACKN-----LQGSYVCVCDEGFTPTQDQHGCEEVE 911
            +                       G C N       GS+ C C EG         C +V 
Sbjct: 854  ACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV- 912

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLC 971
                 + C+L +D+   C   L        CCCS+GA WG  CE   CP   S EF SLC
Sbjct: 913  ---RLEPCFLRWDEDE-CGVTLPGKYRMDVCCCSIGAVWGVECE--ACPDPESLEFASLC 966

Query: 972  PDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNL 1031
            P G G+   + +   G P ++D++EC +F   +C  G C NT   + C C  GF  D   
Sbjct: 967  PRGLGFASRDFL--SGRPFYKDVNECKVFPG-LCTHGTCRNTVGSFHCACAGGFALDAQE 1023

Query: 1032 LECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYS-PAQRQCLSPEEMERAPE--R 1087
              C D+DEC +    C  G C NT G + C C P  E      + C+  +E  R P   R
Sbjct: 1024 RNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCR 1083

Query: 1088 RDVCWSQRG---------------------------EDGMCAGPLAGPALTFDDCCCRQG 1120
               C +  G                            DG+C        +    C C  G
Sbjct: 1084 GGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAG 1143

Query: 1121 ------RGWGAQCRPCPPRGAGS--HCPTSQSESNSFWDTSPLLL--GKPPRDEDSSEED 1170
                  R        C  +  G   HC  ++            L+  G+   D D  EE+
Sbjct: 1144 FQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203

Query: 1171 SDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTS 1230
               C    G C   PGG  C C  GF        CVD+DEC +LN    +C    C NT 
Sbjct: 1204 PRVCD--QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC-DLNPH--ICLHGDCENTK 1258

Query: 1231 GSFRCVCKAGF 1241
            GSF C C+ G+
Sbjct: 1259 GSFVCHCQLGY 1269



 Score =  369 bits (946), Expect = e-101
 Identities = 307/1075 (28%), Positives = 438/1075 (40%), Gaps = 221/1075 (20%)

Query: 277  GRCFQDTLPKQP----CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--P 330
            G CF +T  +      C +    G+T+   CC S+G AWG + C  CP    T  +   P
Sbjct: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCC-SLGRAWG-NPCELCPMANTTEYRTLCP 1547

Query: 331  G-----PVR---------------------------GEVGADCPQGYKRLNSTH-CQDIN 357
            G     P R                           G    +CP GY     T  C+DI+
Sbjct: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607

Query: 358  ECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQ 416
            EC+   G+C  G C N  G+Y CVCP  +        C+  +   KS+CFR  +    CQ
Sbjct: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR---KSVCFRHYNGT--CQ 1662

Query: 417  HPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474
            + L   +TR++CCCS  +G+AW   C+ CPT          P    Y IL  +Q      
Sbjct: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPT----------PISPDYQILCGNQA----- 1707

Query: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534
               F   +H   P    +  E P+         +      + P     +       +   
Sbjct: 1708 -PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN-------SILL 1759

Query: 535  PARPYPELISRPSPPTMRWFLPDLPPS-----RSAVEIAPTQV-TETDECRLNQNICGHG 588
                  E  SR SP        ++P S         +++P       +ECR   N+C HG
Sbjct: 1760 ACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHG 1819

Query: 589  ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYR 648
            +C+     Y C C+ G+++      C+D++EC+ +PC  G G C N  GSYNC C  G+ 
Sbjct: 1820 DCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC--GNGTCKNIIGSYNCLCFPGF- 1876

Query: 649  LHVGAGGRSCVDLNECAKPHLCGD---GGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
              V      CVD +EC    L G     G C+N  G + C C  G+ L A     C D +
Sbjct: 1877 --VVTHNGDCVDFDECTT--LVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTN 1931

Query: 706  ECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA-EGSPCSPGWCENLP 763
            EC     +C  G C+N  GSF+CI C PG++ Q    C D++EC+ E + C  G C N P
Sbjct: 1932 ECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQ-SDHCIDIDECSEEPNLCLFGTCTNSP 1989

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDEC------EAGDVC---------DNGICSNTPG--- 805
            GSF+C C  G+  + +G  C D  +       EAG                CS  PG   
Sbjct: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGW 2049

Query: 806  -------------SFQCQCLSGYHL--SRDRSHCEDIDEC-DFPAACIGGDCINTNGSYR 849
                         +FQ  C  G+      D S  ED++EC + P  C  G C+NT+GS+R
Sbjct: 2050 GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR-EDVNECAENPGVCTNGVCVNTDGSFR 2108

Query: 850  CLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE 908
            C CP G+ L   G  C D DECS         G C N+ G + C C +GF P      CE
Sbjct: 2109 CECPFGYSLDFTGINCVDTDECSVGHP--CGQGTCTNVIGGFECACADGFEPGL-MMTCE 2165

Query: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968
            +++      EC LN    + C      + T+    C+  AG            Y+  E  
Sbjct: 2166 DID------ECSLN---PLLC--AFRCHNTEGSYLCTCPAG------------YTLREDG 2202

Query: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC--KEGKCVNTQPGYECYCKQGFY 1026
            ++C                    RD+DEC   G + C  +  +C N    + C C  G  
Sbjct: 2203 AMC--------------------RDVDEC-ADGQQDCHARGMECKNLIGTFACVCPPGMR 2241

Query: 1027 -YDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERA 1084
               G+   C D +EC  + + C NG C NT G +RC C    + SP   +C    ++ + 
Sbjct: 2242 PLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC---HDIRQG 2298

Query: 1085 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPT 1141
            P     C+++  +    +   +  A+T  +CCC  GRGWG +C  CP  G  ++   CP 
Sbjct: 2299 P-----CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPH 2353

Query: 1142 SQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGF 1196
                +                   +   D DECR     C  G C+   G   C C  G+
Sbjct: 2354 GSGYT-------------------AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394

Query: 1197 QLDASRARCVDIDECRELNQR-GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
              DA+   C+D+DEC ++ +    LCK     NT GSF C C  G+        C
Sbjct: 2395 TPDATATTCLDMDECSQVPKPCTFLCK-----NTKGSFLCSCPRGYLLEEDGRTC 2444



 Score =  356 bits (913), Expect = 9e-98
 Identities = 254/779 (32%), Positives = 339/779 (43%), Gaps = 133/779 (17%)

Query: 570  TQVTETDECRLNQNIC-GHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CG 626
            T  ++ DEC +  + C  H  C+  P  +SC C PG+        C D++EC ++   C 
Sbjct: 1276 TGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE--CHDLDECVSQEHRCS 1333

Query: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686
            P RG C+N  GSY C C +G+       G  C D +ECA+     D G C+N PG Y+C 
Sbjct: 1334 P-RGDCLNVPGSYRCTCRQGF----AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE 1388

Query: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745
            C  G+         C+D+DEC   + C  G CEN PG F+CI C  GY   +GGG C D+
Sbjct: 1389 CEMGFDPTEDHR-ACQDVDECAQGNLCAFGSCENLPGMFRCI-CNGGYELDRGGGNCTDI 1446

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV--DEC--EAGDVCDNGI-C 800
            NECA+   C  G C N PGS+ C+C Q +   P G  C+D     C  E  D  D+GI C
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISC 1506

Query: 801  SNTPG----SFQCQCL---------------------------SGYHLSRDRSHCEDIDE 829
            S   G       C C                             G+  +R     EDIDE
Sbjct: 1507 SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566

Query: 830  C-DFPAACIGGDCINTNGSYRCLCPQGHRLVGG-RKCQDIDECSQDPSLCLPHGACKNLQ 887
            C + P  C GGDC+NT GS++C CP G+ L    R C+DIDECS    +C P G C N  
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTL 1625

Query: 888  GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS-- 945
            G+Y CVC   +      + C ++     K  C+ +++ T  C + LA NVT++ CCCS  
Sbjct: 1626 GNYTCVCPAEYLQVNGGNNCMDMR----KSVCFRHYNGT--CQNELAFNVTRKMCCCSYN 1679

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPD-GKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004
            +G  W   CE  P P+  S ++  LC +   G+  D   ++ G P   DIDEC    + I
Sbjct: 1680 IGQAWNRPCEACPTPI--SPDYQILCGNQAPGFLTD---IHTGKPL--DIDECGEIPA-I 1731

Query: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD-ESNCR-NGVCENTRGGYRCAC 1062
            C  G C+N    + C C  GF Y+  LL C DVDEC   ES C+ N  C N  G YRC C
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791

Query: 1063 TPPAEYSPA-----------------------------------------QRQCLSPEEM 1081
            T   + SP                                          Q  C+  +E 
Sbjct: 1792 TRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC 1851

Query: 1082 ERAPERRDVCWSQRGEDGMCAGP-----LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAG 1136
            +R P     C +  G       P       G  + FD+C    G+     CR        
Sbjct: 1852 DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQ----VCR-------F 1900

Query: 1137 SHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGF 1196
             HC  +    +        L        D++E  S    C+ G C    G   C CP GF
Sbjct: 1901 GHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGF 1960

Query: 1197 QLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255
            Q+ +    C+DIDEC E      LC    C N+ GSF+C+C  GF  S     C   R+
Sbjct: 1961 QVQSDH--CIDIDECSEEPN---LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQ 2014



 Score =  343 bits (879), Expect = 8e-94
 Identities = 230/717 (32%), Positives = 318/717 (44%), Gaps = 77/717 (10%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            +T+EC      C  G C      + C C PG++    H  C+D++EC  EP     G C 
Sbjct: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--------------------------CAKP 667
            N+ GS+ C C  G+ L     G  C D  +                          C+K 
Sbjct: 1987 NSPGSFQCLCPPGFVL--SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKR 2044

Query: 668  HLCGDGGFCINFPGH----YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722
               G G  C   P      ++  C  G+          ED++EC + P  C +G C N  
Sbjct: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTD 2104

Query: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781
            GSF+C  C  GY     G  C D +EC+ G PC  G C N+ G F C CA G+ P     
Sbjct: 2105 GSFRC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-M 2162

Query: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACI--G 838
            +C D+DEC    +     C NT GS+ C C +GY L  D + C D+DEC D    C   G
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222

Query: 839  GDCINTNGSYRCLCPQGHRLV--GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
             +C N  G++ C+CP G R +   G  C D +EC   P LC+ +G C N  GS+ C CDE
Sbjct: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDE 2281

Query: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHC 954
            GF P+     C ++ Q      C+     T+ C S+ +++  VT+ ECCC  G GWG  C
Sbjct: 2282 GFQPSPTLTECHDIRQG----PCFAEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336

Query: 955  EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014
            E+  CP+  ++ +  LCP G GYT +           RD+DEC +  + +C  G+C+N+ 
Sbjct: 2337 EL--CPLPGTSAYRKLCPHGSGYTAEG----------RDVDECRML-AHLCAHGECINSL 2383

Query: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
              + C+C+ G+  D     C+D+DEC         +C+NT+G + C+C          R 
Sbjct: 2384 GSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRT 2443

Query: 1075 CLSPEEM-ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPR 1133
            C   +E   R    + +C +  G    C  P   P  T     C       AQ  PC   
Sbjct: 2444 CKDLDECTSRQHNCQFLCVNTVGAF-TCRCP---PGFTQHHQACFDNDECSAQPGPC--- 2496

Query: 1134 GAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECP 1193
            GA  HC  +             L+      ED +E D    RC  G C  + GG  C CP
Sbjct: 2497 GAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPH-RCQHG-CQNQLGGYRCSCP 2554

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
             GF   +  A+CVD +EC         C S  C NT G FRCVC +GF   +  G C
Sbjct: 2555 QGFTQHSQWAQCVDENECA---LSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608



 Score =  320 bits (819), Expect = 7e-87
 Identities = 302/1116 (27%), Positives = 391/1116 (35%), Gaps = 295/1116 (26%)

Query: 332  PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            P       +C  GY +     C D++EC     C HGDC+N PG+Y C C PG    P+R
Sbjct: 426  PTPSSYRCECNVGYTQDVRGECIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTR 484

Query: 392  TQCIADKPE---EKSLCF--RLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTD 446
              C+ D  E      LC   R V+ E   Q           C C+ G       + C   
Sbjct: 485  QACV-DVDECIVSGGLCHLGRCVNTEGSFQ-----------CVCNAGFELSPDGKNCVDH 532

Query: 447  GTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE--SPSQAPPPE 504
               A   +C  G   +   S   L   G      FL   G      + E  +P       
Sbjct: 533  NECATSTMCVNGVCLNEDGSFSCLCKPG------FLLAPGGHYCMDIDECQTPGICVNGH 586

Query: 505  DTEEERG----------VTTDSPVSEERSVQQSHPTATT--TPARPYPELISRP----SP 548
             T  E            V TD  V  +  V+ +   A    + ARP+P  +++     + 
Sbjct: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646

Query: 549  PTMRWFLP-DLPPSRSAVEIAP---------TQVTETDECRLNQNICGHGECVPGPPDYS 598
            P   +  P  L P++ + E            T   + +EC L+  +C +G C      Y 
Sbjct: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYR 706

Query: 599  CHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC 658
            C CN GY +    + C DV+EC         G C N+ GSY+C C  G+  H       C
Sbjct: 707  CVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGF--HFWQDTEIC 764

Query: 659  VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS----------------RPPVCE 702
             D++EC         G C N  G Y C C PG RL  S                +   CE
Sbjct: 765  KDVDECLSSPCV--SGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822

Query: 703  -DIDECRDPSSC----------PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751
             ++      S C          P  +CE  P      AC  G+    G  C DVNEC E 
Sbjct: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDP------ACARGFARMTGVTCDDVNEC-ES 875

Query: 752  SP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV-----------DEC--------- 789
             P  C  G C N  GSFRC C +G      GR C+DV           DEC         
Sbjct: 876  FPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYR 935

Query: 790  -------------------------EAGDVCDNGI-------------------CSNTPG 805
                                     E   +C  G+                   C   PG
Sbjct: 936  MDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPG 995

Query: 806  ------------SFQCQCLSGYHLSRDRSHCEDIDECDF--------------------- 832
                        SF C C  G+ L     +C DIDEC                       
Sbjct: 996  LCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECEC 1055

Query: 833  -----------------------PAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDID 868
                                   P  C GG C NT+GSY+C CP GH L   G  C+DID
Sbjct: 1056 FPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDID 1115

Query: 869  ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            ECS    LC PHG C N+ G++ C C  GF  T D+ GC ++       EC +       
Sbjct: 1116 ECSLSDGLC-PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDI------NECRVQNGG--- 1165

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988
            CD           C C  G                    +SL PDG+             
Sbjct: 1166 CDVHCINTEGSYRCSCGQG--------------------YSLMPDGR------------- 1192

Query: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCR 1047
             A  D+DEC      +C +G C N   G+ C C  GF    ++  CVDVDEC L+   C 
Sbjct: 1193 -ACADVDECE-ENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICL 1250

Query: 1048 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD---VCWSQRGE-DGMCAG 1103
            +G CENT+G + C C            C   +E E      D    C +  G     C  
Sbjct: 1251 HGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLP 1310

Query: 1104 PLAGPAL---TFDDCCCRQGRGWGAQCRPCPPRG-----AGSH-CPTSQSESNSFWDTSP 1154
               G        D+C  ++ R        C PRG      GS+ C   Q  +        
Sbjct: 1311 GWVGDGFECHDLDECVSQEHR--------CSPRGDCLNVPGSYRCTCRQGFAGD------ 1356

Query: 1155 LLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL 1214
               G    D D   E+ D   C +G+C+  PGG  CEC  GF        C D+DEC + 
Sbjct: 1357 ---GFFCEDRDECAENVD--LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ- 1410

Query: 1215 NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
               G LC    C N  G FRC+C  G+   R  G C
Sbjct: 1411 ---GNLCAFGSCENLPGMFRCICNGGYELDRGGGNC 1443



 Score =  302 bits (774), Expect = 1e-81
 Identities = 234/742 (31%), Positives = 315/742 (42%), Gaps = 148/742 (19%)

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRL----------H 650
            C  G+  +     C DV+EC+A P     G C+N  GS++C C  G+RL           
Sbjct: 232  CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291

Query: 651  VGA------GGRS-------------CVDLNEC----AKPHLCGDGG------FCIN--- 678
             GA      GGR              C D   C      P LC   G       C     
Sbjct: 292  AGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLP 351

Query: 679  -FPGHYKCNCYPG---YRLKASRPPVC------------------------------EDI 704
              PGH     +PG   +      PP+                               + I
Sbjct: 352  LLPGHP--GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTI 409

Query: 705  DECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
            D CR  ++ C +G+C   P S++C  C  GY     G C DV+EC   SPC  G C N+P
Sbjct: 410  DICRHFTNLCLNGRCLPTPSSYRC-ECNVGYTQDVRGECIDVDECTS-SPCHHGDCVNIP 467

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
            G++ C C  G+   P  ++C+DVDEC  +G +C  G C NT GSFQC C +G+ LS D  
Sbjct: 468  GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGK 527

Query: 823  HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHG 881
            +C D +EC     C+ G C+N +GS+ CLC  G  L  GG  C DIDEC Q P +C+ +G
Sbjct: 528  NCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC-QTPGICV-NG 585

Query: 882  ACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQE 941
             C N +GS+ C C  G     D   C +    H +  CY   +    C       VT+ E
Sbjct: 586  HCTNTEGSFRCQCLGGLAVGTDGRVCVDT---HVRSTCYGAIEKGS-CARPFPGTVTKSE 641

Query: 942  CCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLF 1000
            CCC+    G+G+ C++  CP   SAEF +LC  G G T D           RDI+EC L 
Sbjct: 642  CCCANPDHGFGEPCQL--CPAKDSAEFQALCSSGLGITTDG----------RDINECAL- 688

Query: 1001 GSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENTRGGYR 1059
              E+C  G C N +  Y C C  G+    +  +C DVDEC L+   C NG C+N+ G Y 
Sbjct: 689  DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS 748

Query: 1060 CACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
            C+C P   +      C   +E          C S     G+C   LAG       C C  
Sbjct: 749  CSCPPGFHFWQDTEICKDVDE----------CLSSPCVSGVCRN-LAGSYT----CKC-- 791

Query: 1120 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1179
              G G++  P     +G+ C    S   + W     L  +  R E + +  S    C + 
Sbjct: 792  --GPGSRLDP-----SGTFC--LDSTKGTCW-----LKIQESRCEVNLQGASLRSECCA- 836

Query: 1180 RCVPRPGGAVCE-------CPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGS 1232
              +    G+ CE       C  GF    +   C D++EC        +C + RCVNT+GS
Sbjct: 837  -TLGAAWGSPCERCEIDPACARGFAR-MTGVTCDDVNECESFPG---VCPNGRCVNTAGS 891

Query: 1233 FRCVCKAGFARSRPHGACVPQR 1254
            FRC C  G         CV  R
Sbjct: 892  FRCECPEGLMLDASGRLCVDVR 913



 Score =  267 bits (683), Expect = 4e-71
 Identities = 257/902 (28%), Positives = 346/902 (38%), Gaps = 206/902 (22%)

Query: 322  LQYTGVQKPGP---VRGEVGADCPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSY 377
            L   G   PG    + G     CP G++ + S HC DI+EC+  P +C  G C N+PGS+
Sbjct: 1934 LSLAGTCLPGTCQNLEGSFRCICPPGFQ-VQSDHCIDIDECSEEPNLCLFGTCTNSPGSF 1992

Query: 378  RCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSV--GKA 435
            +C+CPPG  L  +  +C   +   +S CF       +C  P     T+  CCCS   G+ 
Sbjct: 1993 QCLCPPGFVLSDNGHRCFDTR---QSFCFTRFEAG-KCSVPKAFNTTKTRCCCSKRPGEG 2048

Query: 436  WGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE 495
            WG  C            E+CP                +G + F            +  P 
Sbjct: 2049 WGDPC------------ELCPQ---------------EGSAAFQ-----------ELCPF 2070

Query: 496  SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFL 555
                 P P+D+ E+     ++P      V  +     T  +                 F 
Sbjct: 2071 GHGAVPGPDDSREDVNECAENP-----GVCTNGVCVNTDGS-----------------FR 2108

Query: 556  PDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV 615
             + P   S ++       +TDEC +    CG G C      + C C  G+        C 
Sbjct: 2109 CECPFGYS-LDFTGINCVDTDECSVGHP-CGQGTCTNVIGGFECACADGFEPGLMMT-CE 2165

Query: 616  DVNECEAEP--CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHL-CGD 672
            D++EC   P  C      C NT GSY C C  GY L     G  C D++ECA     C  
Sbjct: 2166 DIDECSLNPLLCAFR---CHNTEGSYLCTCPAGYTLR--EDGAMCRDVDECADGQQDCHA 2220

Query: 673  GGF-CINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIAC 730
             G  C N  G + C C PG R        C D +EC   P  C +G+C N  GSF+C  C
Sbjct: 2221 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC-DC 2279

Query: 731  QPGYR-SQGGGACRDVNE-----------CAEGSPCSP-------------GW---CE-- 760
              G++ S     C D+ +           C   S  S              GW   CE  
Sbjct: 2280 DEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELC 2339

Query: 761  NLPGS--FRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGSFQCQCLSGYHL 817
             LPG+  +R  C  G     +GR   DVDEC     +C +G C N+ GSF+C C +GY  
Sbjct: 2340 PLPGTSAYRKLCPHGSGYTAEGR---DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTP 2396

Query: 818  SRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPS 875
                + C D+DEC   P  C    C NT GS+ C CP+G+ L   GR C+D+DEC+    
Sbjct: 2397 DATATTCLDMDECSQVPKPCTFL-CKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQH 2455

Query: 876  LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935
             C     C N  G++ C C  GFT               H + C+ N             
Sbjct: 2456 NC--QFLCVNTVGAFTCRCPPGFT--------------QHHQACFDN------------- 2486

Query: 936  NVTQQECCCSLG-AGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDI 994
                 EC    G  G   HC   P        F   C   +G+T    +V+ G     D+
Sbjct: 2487 ----DECSAQPGPCGAHGHCHNTP------GSFRCECH--QGFT----LVSSGHGCE-DV 2529

Query: 995  DECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCEN 1053
            +EC   G   C+ G C N   GY C C QGF       +CVD +EC L    C +  C N
Sbjct: 2530 NECD--GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586

Query: 1054 TRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFD 1113
            T GG+RC C    ++  A   C   +E++    RR  C         CA    G      
Sbjct: 2587 TLGGFRCVCPSGFDFDQALGGC---QEVDECAGRRGPC------SYSCANTPGGFL---- 2633

Query: 1114 DCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1173
             C C QG            R    HC +    S    DT       P ++E  S E   E
Sbjct: 2634 -CGCPQGYF----------RAGQGHCVSGLGFSPGPQDT-------PDKEELLSSEACYE 2675

Query: 1174 CR 1175
            C+
Sbjct: 2676 CK 2677



 Score =  154 bits (389), Expect = 5e-37
 Identities = 177/706 (25%), Positives = 238/706 (33%), Gaps = 208/706 (29%)

Query: 623  EPCGPGR-------GICMNT---GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HL 669
            E  GPGR       GI       G  ++ +C  G+R   G         ++C  P     
Sbjct: 38   EAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGR--------SQCVVPICRRA 89

Query: 670  CGDGGFCINFPGHYKCNCYPGYRLKA---SRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726
            CG+G FC        C C  G    +   SR   C     C +  +C    C        
Sbjct: 90   CGEG-FCSQ---PNLCTCADGTLAPSCGVSRGSGCSV--SCMNGGTCRGASC-------- 135

Query: 727  CIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
               CQ GY     G       C  G  C  P  C  + G     C + Y   P     + 
Sbjct: 136  --LCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQ-VG 192

Query: 786  VDECE---AGDVCDNGICSNTPG---SFQCQ--------CLSGYHLSRDRSHCEDIDECD 831
             + C+    G VC   +C  T G      C+        C  G+  +     C+D+DEC 
Sbjct: 193  PEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ 252

Query: 832  -FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGS 889
              P  C GG C+N  GS+ C CP GHRL      C+D              GAC ++   
Sbjct: 253  AVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-----------GACFSVLFG 301

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949
              C  D                                     LA + T+++CCC  G  
Sbjct: 302  GRCAGD-------------------------------------LAGHYTRRQCCCDRGRC 324

Query: 950  WGDHCEIYPCPVYSSAEFHSLC---------------------------PDGKGYTQDNN 982
            W        CP   S EF  LC                           P G      + 
Sbjct: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384

Query: 983  IVNYGIPA-------------HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG 1029
                GIP+             ++ ID C  F + +C  G+C+ T   Y C C  G+  D 
Sbjct: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHF-TNLCLNGRCLPTPSSYRCECNVGYTQDV 443

Query: 1030 NLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD 1089
               EC+DVDEC   S C +G C N  G Y C C P  + +P ++ C+  +E         
Sbjct: 444  R-GECIDVDEC-TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDEC-------- 493

Query: 1090 VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSF 1149
                      + +G L           C  GR    +         GS     Q   N+ 
Sbjct: 494  ----------IVSGGL-----------CHLGRCVNTE---------GSF----QCVCNAG 519

Query: 1150 WDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRARC 1205
            ++ SP         +  +  D +EC     CV+G C+   G   C C  GF L      C
Sbjct: 520  FELSP---------DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC 570

Query: 1206 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
            +DIDEC    Q   +C +  C NT GSFRC C  G A       CV
Sbjct: 571  MDIDEC----QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCV 612



 Score =  109 bits (273), Expect = 1e-23
 Identities = 152/597 (25%), Positives = 201/597 (33%), Gaps = 154/597 (25%)

Query: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE--NLPGS-FRCTCAQGYAPAPDG 780
            ++  + C  G + +  GA             SPG  +  N+ GS F   C  G+   P G
Sbjct: 19   AWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFP-G 77

Query: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GG 839
            RS   V  C     C  G CS       C C  G         C          +C+ GG
Sbjct: 78   RSQCVVPICRRA--CGEGFCSQPN---LCTCADGTLAPS----CGVSRGSGCSVSCMNGG 128

Query: 840  DCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
             C   +    CLC +G+    G  C Q I  C +    C   G C    G   C C  GF
Sbjct: 129  TCRGAS----CLCQKGYT---GTVCGQPI--CDRG---CHNGGRCI---GPNRCACVYGF 173

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
               Q        E+ +    C+           +     T+  CC ++G  WG  CE+ P
Sbjct: 174  MGPQ-------CERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
               +         P  +G+     I N    A +D+DEC      +C+ G CVN    + 
Sbjct: 227  AQPH---------PCRRGF-----IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFH 271

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
            C C  G     +   C D          R G C +   G RCA      Y+  +RQC   
Sbjct: 272  CRCPVGHRLSDSSAACEDY---------RAGACFSVLFGGRCAGDLAGHYT--RRQCCCD 320

Query: 1079 EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ------------------G 1120
                     R  CW+      +C  P  G +  F   C ++                   
Sbjct: 321  ---------RGRCWAAGPVPELC--PPRG-SNEFQQLCAQRLPLLPGHPGLFPGLLGFGS 368

Query: 1121 RGWGAQCRPC--PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--- 1175
             G G    P    P G+ +    S    NS   T+ L             +  D CR   
Sbjct: 369  NGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATL------------NQTIDICRHFT 416

Query: 1176 --CVSGRCVPRPGGAVCEC-------------------------------PG-------- 1194
              C++GRC+P P    CEC                               PG        
Sbjct: 417  NLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYP 476

Query: 1195 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
            GFQ   +R  CVD+DEC      G LC   RCVNT GSF+CVC AGF  S     CV
Sbjct: 477  GFQATPTRQACVDVDEC---IVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCV 530



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 94/335 (28%), Positives = 120/335 (35%), Gaps = 88/335 (26%)

Query: 583 NICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV--------------DVNECE------A 622
           N+CG          +  +C PG+R+ P    CV                N C       A
Sbjct: 58  NVCGSR--------FHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLA 109

Query: 623 EPCGPGRG-----ICMNTG--GSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HLCGD 672
             CG  RG      CMN G     +C C +GY   V            C +P     C +
Sbjct: 110 PSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTV------------CGQPICDRGCHN 157

Query: 673 GGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732
           GG CI   G  +C C  G+       P CE     RD  +   G C  + G   C     
Sbjct: 158 GGRCI---GPNRCACVYGF-----MGPQCE-----RDYRT---GPCFGQVGPEGCQHQLT 201

Query: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA- 791
           G        C  V   A G PC    C   P      C +G+ P     +C DVDEC+A 
Sbjct: 202 GLVCTKALCCATVGR-AWGLPCE--LCPAQPH----PCRRGFIPNIHTGACQDVDECQAV 254

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI-NTNGSY-- 848
             +C  G C N  GSF C+C  G+ LS   + CED       +   GG C  +  G Y  
Sbjct: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTR 314

Query: 849 -RCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGA 882
            +C C +G     G            P LC P G+
Sbjct: 315 RQCCCDRGRCWAAG----------PVPELCPPRGS 339



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 19/104 (18%)

Query: 359 CAMPGVCRHGDCLNNPGSYRCVCPP----------GHSLGPSRTQCI-------ADKPEE 401
           C   G CR   CL   G    VC            G  +GP+R  C+        ++   
Sbjct: 124 CMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYR 183

Query: 402 KSLCFRLVSPEHQCQHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444
              CF  V PE  CQH LT  + T+ LCC +VG+AWG  C+ CP
Sbjct: 184 TGPCFGQVGPE-GCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 64/247 (25%), Positives = 78/247 (31%), Gaps = 81/247 (32%)

Query: 1010 CVN--TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAE 1067
            C+N  T  G  C C++G  Y G +       + + +  C NG      G  RCAC     
Sbjct: 124  CMNGGTCRGASCLCQKG--YTGTVC-----GQPICDRGCHNG--GRCIGPNRCACV---- 170

Query: 1068 YSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1127
            Y     QC           R   C+ Q G +G C   L G   T   CC   GR WG   
Sbjct: 171  YGFMGPQC-------ERDYRTGPCFGQVGPEG-CQHQLTGLVCTKALCCATVGRAWGL-- 220

Query: 1128 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGG 1187
             PC        CP                                          P P  
Sbjct: 221  -PC------ELCPAQ----------------------------------------PHP-- 231

Query: 1188 AVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPH 1247
                C  GF  +     C D+DEC+ +     LC+   CVN  GSF C C  G   S   
Sbjct: 232  ----CRRGFIPNIHTGACQDVDECQAVPG---LCQGGSCVNMVGSFHCRCPVGHRLSDSS 284

Query: 1248 GACVPQR 1254
             AC   R
Sbjct: 285  AACEDYR 291



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 12/93 (12%)

Query: 304  CGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-THCQDINECAM- 361
            C  +    G  +C    Q Q  G +            CPQG+ + +    C D NECA+ 
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR----------CSCPQGFTQHSQWAQCVDENECALS 2575

Query: 362  PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            P  C    C N  G +RCVCP G     +   C
Sbjct: 2576 PPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 59/201 (29%), Positives = 71/201 (35%), Gaps = 51/201 (25%)

Query: 20  AAGLLALLLLL---LLLLLGLGGRVEG-----GPAGERGAGGGGAL-----ARERFKVVF 66
           A G LA LLL    LL + G  GR +G     GP   R  G  G L        RF    
Sbjct: 9   ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC 68

Query: 67  AP-------------VICKRTCLKGQCRD-------------SC--QQGSNMTLIGENG- 97
            P              IC+R C +G C               SC   +GS  ++   NG 
Sbjct: 69  CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG 128

Query: 98  --HSTDTLTGSGFRVVVCPLP-----CMNGGQCSSRNQCLCPPDFTGRFCQ--VPAGGAG 148
                  L   G+   VC  P     C NGG+C   N+C C   F G  C+     G   
Sbjct: 129 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188

Query: 149 GGTGGSGPGLSRTGALSTGAL 169
           G  G  G     TG + T AL
Sbjct: 189 GQVGPEGCQHQLTGLVCTKAL 209



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 47/189 (24%), Positives = 65/189 (34%), Gaps = 43/189 (22%)

Query: 277  GRCFQDTLPKQPCG-SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP--- 332
            G CF + L       S+    +T+ E CCG  G  WG  +C  CP    +  +K  P   
Sbjct: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-GRGWGP-RCELCPLPGTSAYRKLCPHGS 2355

Query: 333  --------------------------VRGEVGADCPQGYKR-LNSTHCQDINECA-MPGV 364
                                        G     C  GY     +T C D++EC+ +P  
Sbjct: 2356 GYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKP 2415

Query: 365  CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLT 424
            C    C N  GS+ C CP G+ L      C     ++   C    S +H CQ      + 
Sbjct: 2416 CTFL-CKNTKGSFLCSCPRGYLLEEDGRTC-----KDLDEC---TSRQHNCQFLCVNTVG 2466

Query: 425  RQLCCCSVG 433
               C C  G
Sbjct: 2467 AFTCRCPPG 2475



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 41/163 (25%), Positives = 61/163 (37%), Gaps = 35/163 (21%)

Query: 251  ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310
            E +A  Q L P    + P P   +      +D      C  NP  G+     C  + G+ 
Sbjct: 2059 EGSAAFQELCPFGHGAVPGPDDSR------EDV---NECAENP--GVCTNGVCVNTDGSF 2107

Query: 311  WGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQG----------------YKRLNST 351
                +C +CP    L +TG+         VG  C QG                ++     
Sbjct: 2108 ----RC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162

Query: 352  HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
             C+DI+EC++  +     C N  GSY C CP G++L      C
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  443 bits (1140), Expect = e-124
 Identities = 310/999 (31%), Positives = 431/999 (43%), Gaps = 162/999 (16%)

Query: 293  PLPGLTKQEDCCGSIGTAWGQSKCHKCPQL---QYTGVQKPGPVRGEVGADCPQGYKRLN 349
            P+ G  + + CC S+G AWG  +C +CP     +Y  +   GP  G    +   G     
Sbjct: 970  PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGP--GFATKEITNG----- 1022

Query: 350  STHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLCF 406
                +DINEC M P +C HG C N  GS++C C  G +L      C  I +      LC 
Sbjct: 1023 KPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCG 1082

Query: 407  R---LVSP---EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCP----------TDGTAA 450
            R   + +P   E +C     +       C  + +     CQR P          T+G+  
Sbjct: 1083 RGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDE-----CQRDPLLCRGGVCHNTEGS-- 1135

Query: 451  FKEICPAGKGYHILTSHQTLTIQ-GESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509
            ++  CP G   H L+ + +  I   E + S  L P+G      + +      P   +  +
Sbjct: 1136 YRCECPPG---HQLSPNISACIDINECELSAHLCPNGRCV-NLIGKYQCACNPGYHSTPD 1191

Query: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            R    D    +E S+         T +    E   +P    M       P  RS  +I  
Sbjct: 1192 RLFCVDI---DECSIMNGGCETFCTNSEGSYECSCQPGFALM-------PDQRSCTDI-- 1239

Query: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
                  DEC  N NIC  G+C   P +Y C C  G+ +    + CVDVNEC+  P     
Sbjct: 1240 ------DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLS 1293

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688
            G C NT GS+ CHC+ GY    G  G  C D+NEC    H CG    C N  G +KC+C 
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTG--CTDINECEIGAHNCGKHAVCTNTAGSFKCSCS 1351

Query: 689  PGYRLKASRPPVCEDIDECRDPSSC--PDGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746
            PG+     +   C D+DEC + +        C+N  GS++C+ C+ GY   G   C D++
Sbjct: 1352 PGWIGDGIK---CTDLDECSNGTHMCSQHADCKNTMGSYRCL-CKEGYTGDGF-TCTDLD 1406

Query: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805
            EC+E  + C  G C N PG +RC C  G+ P+ DG++C D+DEC   ++C  G C N PG
Sbjct: 1407 ECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPG 1466

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
             F+C+C  GY L R   +C D++EC  P  CI G+C+NT GSY C CP    L       
Sbjct: 1467 LFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL------- 1519

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923
                                              PT  + GC +    +    CYL+   
Sbjct: 1520 ---------------------------------NPT--RVGCVDTRSGN----CYLDIRP 1540

Query: 924  ---DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD 980
               +    C + +   V++  CCCSLG  WG  CE+  CP  +++E+  LCP G+G+  +
Sbjct: 1541 RGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEM--CPAVNTSEYKILCPGGEGFRPN 1598

Query: 981  NNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1040
               V        DIDEC      +C+ GKC+NT   ++C C  G+Y + +   C DV+EC
Sbjct: 1599 PITV-----ILEDIDECQELPG-LCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC 1652

Query: 1041 LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGM 1100
                 C  G C NT G Y C C P          C+          RR +C+     D  
Sbjct: 1653 ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMD--------MRRSLCYRNYYADNQ 1704

Query: 1101 -CAGPLAGPALTFDDCCCRQ--GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL 1157
             C G L    +T   CCC    GR W   C  CP            S+   F     +  
Sbjct: 1705 TCDGELLF-NMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGF--VIDIYT 1761

Query: 1158 GKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1212
            G P         D DECR     C +G C+   G   CECP GF  +     C DIDEC 
Sbjct: 1762 GLP--------VDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDEC- 1812

Query: 1213 ELNQRGLLC-KSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
               Q G +C ++  C+NT+GS+RC CK G+ R    G C
Sbjct: 1813 ---QNGPVCQRNAECINTAGSYRCDCKPGY-RFTSTGQC 1847



 Score =  397 bits (1020), Expect = e-110
 Identities = 313/1090 (28%), Positives = 442/1090 (40%), Gaps = 234/1090 (21%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY-----------T 325
            G CF   +  Q C       +  +  CC ++G AWG   C  CP   +           T
Sbjct: 184  GPCFT-VISNQMCQGQLSGIVCTKTLCCATVGRAWGHP-CEMCPAQPHPCRRGFIPNIRT 241

Query: 326  GVQK--------PGPVRG-----EVGA---DCPQGYKRLN--STHCQDINECA-MPGVCR 366
            G  +        PG  +G      VG+    CP G+K LN  S  C+DI+EC+ +PG+C 
Sbjct: 242  GACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHK-LNEVSQKCEDIDECSTIPGICE 300

Query: 367  HGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQ 426
             G+C N   SY C CPPG    P  T+CI  +P     C+  ++   +C + L   +T+ 
Sbjct: 301  GGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRP---GYCYTALT-NGRCSNQLPQSITKM 356

Query: 427  LCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG 486
             CCC  G+ W        + G     E+CP               I+   DF+       
Sbjct: 357  QCCCDAGRCW--------SPGVTVAPEMCP---------------IRATEDFNKLC---- 389

Query: 487  PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRP 546
               P  +P  P   PPP             P+          P     P  P    I  P
Sbjct: 390  -SVPMVIPGRPEYPPPPL-----------GPIP---------PVLPVPPGFPPGPQIPVP 428

Query: 547  SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYR 606
             PP     +  L PSR    + P  V  TD C+L + +C +G C+P P    C CN G++
Sbjct: 429  RPP-----VEYLYPSREPPRVLPVNV--TDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQ 481

Query: 607  SHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK 666
               +   C+DV+ECE  PC  G   C+N  GSY C C  GY+  +      C D++EC +
Sbjct: 482  LDLRGE-CIDVDECEKNPCAGGE--CINNQGSYTCQCRAGYQSTLTR--TECRDIDECLQ 536

Query: 667  PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726
                 + G CIN  G + C C  G+ +       CED+DEC   + C +G C N+ GSFK
Sbjct: 537  NGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN-CEDMDECSIRNMCLNGMCINEDGSFK 595

Query: 727  CIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
            CI C+PG++ +  G  C+D+NEC     C  G C N  GS+RC C  G A   DGR C+D
Sbjct: 596  CI-CKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVD 654

Query: 786  V-------------------------DEC-------EAGDVCD----------NGICSNT 803
                                       EC         G+ C             +CS+ 
Sbjct: 655  THMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG 714

Query: 804  PG----------------------------SFQCQCLSGYHLSRDRSHCEDIDECDFPA- 834
            PG                            +++C C SGY +     +C DI+EC   + 
Sbjct: 715  PGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSL 774

Query: 835  ACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             C  G C NT GS+ C CP+G       K C+DIDEC   P +   +G CKN  GS++C 
Sbjct: 775  LCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCI---NGVCKNSPGSFICE 831

Query: 894  CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDH 953
            C    T    +  C E      K  C+    D   C+  +     + +CC SLGA WG  
Sbjct: 832  CSSESTLDPTKTICIET----IKGTCWQTVIDG-RCEININGATLKSQCCSSLGAAWGSP 886

Query: 954  CEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNT 1013
            C +         +   +C  GKGY++             DIDEC +F   +CK G CVNT
Sbjct: 887  CTL--------CQVDPIC--GKGYSRIKG------TQCEDIDECEVFPG-VCKNGLCVNT 929

Query: 1014 QPGYECYCKQGFYYDGNLLECVDV--DECL---DESNCRNGVCENTRGGYRCACTPPAEY 1068
            +  ++C C  G   D     C+D+  + C    ++  C   +    R    C C+  A +
Sbjct: 930  RGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMD-ACCCSVGAAW 988

Query: 1069 SPAQ-RQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1127
               +  +C     M   PE  ++C   RG  G     +      F D           +C
Sbjct: 989  GTEECEEC----PMRNTPEYEELC--PRG-PGFATKEITNGKPFFKDI---------NEC 1032

Query: 1128 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCV 1182
            +  P       C  +        D+     G     E+ +  D DECR     C  G+CV
Sbjct: 1033 KMIPSLCTHGKCRNTIGSFKCRCDS-----GFALDSEERNCTDIDECRISPDLCGRGQCV 1087

Query: 1183 PRPGGAVCECPGGFQLDASRAR-CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
              PG   C+C  G++      + C+DIDEC+   +  LLC+   C NT GS+RC C  G 
Sbjct: 1088 NTPGDFECKCDEGYESGFMMMKNCMDIDECQ---RDPLLCRGGVCHNTEGSYRCECPPGH 1144

Query: 1242 ARSRPHGACV 1251
              S    AC+
Sbjct: 1145 QLSPNISACI 1154



 Score =  390 bits (1003), Expect = e-108
 Identities = 233/712 (32%), Positives = 335/712 (47%), Gaps = 99/712 (13%)

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRS-HPQHRYCVDVNECEA 622
            A++      T+ DECR++ ++CG G+CV  P D+ C C+ GY S     + C+D++EC+ 
Sbjct: 1060 ALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQR 1119

Query: 623  EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPG 681
            +P     G+C NT GSY C C  G++L       +C+D+NEC    HLC +G  C+N  G
Sbjct: 1120 DPLLCRGGVCHNTEGSYRCECPPGHQLSPNIS--ACIDINECELSAHLCPNGR-CVNLIG 1176

Query: 682  HYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGG 740
             Y+C C PGY     R   C DIDEC   +   +  C N  GS++C +CQPG+       
Sbjct: 1177 KYQCACNPGYHSTPDR-LFCVDIDECSIMNGGCETFCTNSEGSYEC-SCQPGFALMPDQR 1234

Query: 741  ACRDVNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDNG 798
            +C D++EC +  + C  G C N+PG +RC C  G+  + D ++C+DV+EC+   ++C +G
Sbjct: 1235 SCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSG 1294

Query: 799  ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG--GDCINTNGSYRCLCPQGH 856
             C NT GSF C C  GY   + ++ C DI+EC+  A   G    C NT GS++C C  G 
Sbjct: 1295 TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW 1354

Query: 857  RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHK 916
             +  G KC D+DECS    +C  H  CKN  GSY C+C EG+  T D   C +++     
Sbjct: 1355 -IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLD----- 1406

Query: 917  KECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKG 976
             EC  N             N+     C +   G+   C++   P            DGK 
Sbjct: 1407 -ECSENL------------NLCGNGQCLNAPGGYRCECDMGFVP----------SADGK- 1442

Query: 977  YTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVD 1036
                         A  DIDEC L    IC  G C N    + C C+ G+  D +   C D
Sbjct: 1443 -------------ACEDIDECSL--PNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487

Query: 1037 VDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW---S 1093
            V+ECLD + C +G C NT G Y C C P  E +P +  C+          R   C+    
Sbjct: 1488 VNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVD--------TRSGNCYLDIR 1539

Query: 1094 QRGEDG--MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNS 1148
             RG++G   C+  + G  ++   CCC  G+ WG  C  CP      +   CP  +     
Sbjct: 1540 PRGDNGDTACSNEI-GVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGE----- 1593

Query: 1149 FWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRA 1203
                     G  P       ED DEC+     C  G+C+   G   C CP G+ L+    
Sbjct: 1594 ---------GFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTR 1644

Query: 1204 RCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255
             C D++EC        +C    C NT G++ C+C   + +      C+  RR
Sbjct: 1645 VCDDVNECETPG----ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRR 1692



 Score =  358 bits (920), Expect = 1e-98
 Identities = 236/761 (31%), Positives = 327/761 (42%), Gaps = 128/761 (16%)

Query: 574  ETDECRL-NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGR- 629
            + DEC   N N+C +G+C+     + C CN GY   P  R CVD+NEC  EP  C PG  
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTC 1989

Query: 630  -------------------------------------GICMNTGGSYNCHCNRGYRLHVG 652
                                                 G C NT GS+ C C  G+ L   
Sbjct: 1990 QNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSL--S 2047

Query: 653  AGGRSCVDLN-----------ECAKPH------------LCGDGG-----FCINFPGH-Y 683
            + GR C DL            +C+ P             L G+G       C   P   +
Sbjct: 2048 SSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAF 2107

Query: 684  KCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR 743
            +  C  G  +         D+DEC++P  C  G+C N  GS++C  C  GY    G  C 
Sbjct: 2108 RQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRC-ECPFGY-ILAGNECV 2165

Query: 744  DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNT 803
            D +EC+ G+PC  G C+N+ G F CTC +G+ P P   +C D++EC    +     C NT
Sbjct: 2166 DTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPM-MTCEDINECAQNPLLCAFRCVNT 2224

Query: 804  PGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIGGDCINTNGSYRCLCPQGH-RLV 859
             GS++C+C  GY L  DR  C+D DEC+           +C N  G+Y C+C  G+ R  
Sbjct: 2225 YGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRP 2284

Query: 860  GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919
             G  C D +EC   P +C  +G C N +GSY C C++GFT + +Q  C +  + +   E 
Sbjct: 2285 DGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEV 2343

Query: 920  YLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ 979
              N        S     VT+ ECCC  G GWG HCEI  CP   +  F  LCP G+G+  
Sbjct: 2344 LQNMCQI---GSSNRNPVTKSECCCDGGRGWGPHCEI--CPFQGTVAFKKLCPHGRGFMT 2398

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039
            +            DIDEC +   ++C+ G+CVN +  Y C CK G+  D     CVD++E
Sbjct: 2399 NG----------ADIDECKVI-HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNE 2447

Query: 1040 CLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDG 1099
            C       N +C+NT G Y+C+C          R C   ++++    ++  C        
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC---KDLDECATKQHNC------QF 2498

Query: 1100 MCAGPLAG------PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1153
            +C   + G      P  T     C       +    C  +G   + P S         T 
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGS--------FTC 2550

Query: 1154 PLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDID 1209
                G       SS ED DEC    RC  G C    GG  C CP G+       +CVD +
Sbjct: 2551 ECQRGFSLDQTGSSCEDVDECEGNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDEN 2609

Query: 1210 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            EC   +    +C    C NT GS++C+C AGF   +  G C
Sbjct: 2610 ECLSAH----ICGGASCHNTLGSYKCMCPAGFQYEQFSGGC 2646



 Score =  350 bits (897), Expect = 6e-96
 Identities = 243/767 (31%), Positives = 332/767 (43%), Gaps = 163/767 (21%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGRGI 631
            + +EC LN NIC  G C      + CHC+ GY        C D+NECE  A  CG    +
Sbjct: 1280 DVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGK-HAV 1338

Query: 632  CMNTGGSYNCHCNRG---------------------------------YRLHVGAG---- 654
            C NT GS+ C C+ G                                 YR     G    
Sbjct: 1339 CTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGD 1398

Query: 655  GRSCVDLNECAKP-HLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSC 713
            G +C DL+EC++  +LCG+G  C+N PG Y+C C  G+ + ++    CEDIDEC  P+ C
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQ-CLNAPGGYRCECDMGF-VPSADGKACEDIDECSLPNIC 1456

Query: 714  PDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQ 772
              G C N PG F+C  C+ GY   + GG C DVNEC + + C  G C N PGS+ C C  
Sbjct: 1457 VFGTCHNLPGLFRC-ECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPP 1515

Query: 773  GYAPAPDGRSCLD-------VDECEAGDVCDNGICSNTPG----------------SFQC 809
             +   P    C+D       +D    GD  D   CSN  G                   C
Sbjct: 1516 DFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTA-CSNEIGVGVSKASCCCSLGKAWGTPC 1574

Query: 810  QCLSGYHLSRDRSHC---------------EDIDEC-DFPAACIGGDCINTNGSYRCLCP 853
            +     + S  +  C               EDIDEC + P  C GG CINT GS++C CP
Sbjct: 1575 EMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCP 1634

Query: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
             G+ L    R C D++EC + P +C P G C N  G+Y C+C   +      + C ++  
Sbjct: 1635 TGYYLNEDTRVCDDVNEC-ETPGICGP-GTCYNTVGNYTCICPPDYMQVNGGNNCMDMR- 1691

Query: 913  PHHKKECYLNF-DDTVFCDSVLATNVTQQECCCS--LGAGWGDHCEIYPCPVYSSAEFHS 969
               +  CY N+  D   CD  L  N+T++ CCCS  +G  W   CE   CP+ S+ EF +
Sbjct: 1692 ---RSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCE--QCPIPSTDEFAT 1746

Query: 970  LCPDGK-GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028
            LC   + G+  D   +  G+P   DIDEC      +C+ G C+N    + C C  GF+Y+
Sbjct: 1747 LCGSQRPGFVID---IYTGLPV--DIDECREIPG-VCENGVCINMVGSFRCECPVGFFYN 1800

Query: 1029 GNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPER 1087
              LL C D+DEC +   C RN  C NT G YRC C P   ++ +  QC    E +  P  
Sbjct: 1801 DKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFT-STGQCNDRNECQEIP-- 1857

Query: 1088 RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESN 1147
             ++C       G C   +         C C                              
Sbjct: 1858 -NIC-----SHGQCIDTVGS-----FYCLCH----------------------------- 1877

Query: 1148 SFWDTSPLLLGKPPRDEDSSEEDSDECR---CVSGRCVPRPGGAVCECPGGFQLDASRAR 1204
                      G    D+ +   D +EC    C +G C    G   C C  GF L  +   
Sbjct: 1878 ---------TGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNN-D 1927

Query: 1205 CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
            C+D+DEC   N  G LC++ +C+NT GSF+C C  G+  +     CV
Sbjct: 1928 CIDVDECASGN--GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCV 1972



 Score =  347 bits (891), Expect = 3e-95
 Identities = 225/690 (32%), Positives = 306/690 (44%), Gaps = 129/690 (18%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + DECR    +C +G C+     + C C  G+  + +   C D++EC+  P       C+
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI 1825

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYR 692
            NT GSY C C  GYR         C D NEC + P++C  G  CI+  G + C C+ G++
Sbjct: 1826 NTAGSYRCDCKPGYRF---TSTGQCNDRNECQEIPNICSHGQ-CIDTVGSFYCLCHTGFK 1881

Query: 693  LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752
                +  +C DI+EC +  +C +G C N  GSF C  C  G+       C DV+ECA G+
Sbjct: 1882 TNDDQ-TMCLDINEC-ERDACGNGTCRNTIGSFNC-RCNHGFILSHNNDCIDVDECASGN 1938

Query: 753  P--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNGICSNTPGSFQC 809
               C  G C N  GSF+C C +GY  APDGR+C+D++EC      C  G C N  GS++C
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC 1998

Query: 810  QCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDI 867
             C  GY L  ++  CEDIDEC + P  C  G C NT GS++CLCP+G  L   GR+CQD 
Sbjct: 1999 ICPPGYSLQNEK--CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQD- 2055

Query: 868  DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV 927
                              L+ SY                            CY  F+   
Sbjct: 2056 ------------------LRMSY----------------------------CYAKFEGGK 2069

Query: 928  FCDSVLATNVTQQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT--QDNNIV 984
             C S  + N ++QECCC+L G GWGD CE+  CP      F  +CP G G     D++ V
Sbjct: 2070 -CSSPKSRNHSKQECCCALKGEGWGDPCEL--CPTEPDEAFRQICPYGSGIIVGPDDSAV 2126

Query: 985  NYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044
                    D+DEC     ++CK G+C+NT   Y C C  G+   GN  ECVD DEC   +
Sbjct: 2127 --------DMDECK--EPDVCKHGQCINTDGSYRCECPFGYILAGN--ECVDTDECSVGN 2174

Query: 1045 NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGP 1104
             C NG C+N  GG+ C C    E  P    C    E  + P              +CA  
Sbjct: 2175 PCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINECAQNPL-------------LCAFR 2220

Query: 1105 LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDE 1164
                  ++ +C C  G       R C                               +DE
Sbjct: 2221 CVNTYGSY-ECKCPVGYVLREDRRMC-------------------------------KDE 2248

Query: 1165 DSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224
            D  EE   +C      C    G  +C C  G+Q       CVD +EC+    +  +C++ 
Sbjct: 2249 DECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQ---TKPGICENG 2305

Query: 1225 RCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254
            RC+NT GS+ C C  GF  S     C+  R
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQDECLDNR 2335



 Score =  338 bits (866), Expect = 2e-92
 Identities = 232/729 (31%), Positives = 323/729 (44%), Gaps = 140/729 (19%)

Query: 571  QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRG 630
            Q  + +EC+   NIC HG+C+     + C C+ G++++     C+D+NECE + C  G G
Sbjct: 1846 QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDAC--GNG 1903

Query: 631  ICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCY 688
             C NT GS+NC CN G+ L   +    C+D++ECA    +LC +G  CIN  G ++C C 
Sbjct: 1904 TCRNTIGSFNCRCNHGFIL---SHNNDCIDVDECASGNGNLCRNGQ-CINTVGSFQCQCN 1959

Query: 689  PGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNE 747
             GY + A     C DI+EC  +P  C  G C+N  GS++CI C PGY  Q    C D++E
Sbjct: 1960 EGYEV-APDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCI-CPPGYSLQ-NEKCEDIDE 2016

Query: 748  CAEGSP-CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV-----------DECEA---- 791
            C E    C+ G C N  GSF+C C +G++ +  GR C D+            +C +    
Sbjct: 2017 CVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSR 2076

Query: 792  ----------------GDVCDNGICSNTPG-SFQ--CQCLSGYHLSRDRSHCEDIDECDF 832
                            GD C+  +C   P  +F+  C   SG  +  D S   D+DEC  
Sbjct: 2077 NHSKQECCCALKGEGWGDPCE--LCPTEPDEAFRQICPYGSGIIVGPDDS-AVDMDECKE 2133

Query: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
            P  C  G CINT+GSYRC CP G+ ++ G +C D DECS        +G CKN+ G + C
Sbjct: 2134 PDVCKHGQCINTDGSYRCECPFGY-ILAGNECVDTDECSVGNP--CGNGTCKNVIGGFEC 2190

Query: 893  VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952
             C+EGF P      CE++       EC  N    + C           EC C +G     
Sbjct: 2191 TCEEGFEP-GPMMTCEDI------NECAQN---PLLCAFRCVNTYGSYECKCPVG----- 2235

Query: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC--KEGKC 1010
                     Y   E   +C                    +D DEC   G   C  K+ +C
Sbjct: 2236 ---------YVLREDRRMC--------------------KDEDECE-EGKHDCTEKQMEC 2265

Query: 1011 VNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYS 1069
             N    Y C C  G+    +   CVD +EC  +   C NG C NTRG Y C C      S
Sbjct: 2266 KNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTAS 2325

Query: 1070 PAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP 1129
            P Q +CL          R   C+++  ++    G      +T  +CCC  GRGWG  C  
Sbjct: 2326 PNQDECLD--------NREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEI 2377

Query: 1130 CPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRC 1181
            CP +G  +    CP                     R   ++  D DEC+     C +G C
Sbjct: 2378 CPFQGTVAFKKLCPHG-------------------RGFMTNGADIDECKVIHDVCRNGEC 2418

Query: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            V   G   C C  G+  D +   CVD++EC   NQ    C +  C NT GS++C C  G+
Sbjct: 2419 VNDRGSYHCICKTGYTPDITGTSCVDLNEC---NQAPKPC-NFICKNTEGSYQCSCPKGY 2474

Query: 1242 ARSRPHGAC 1250
                   +C
Sbjct: 2475 ILQEDGRSC 2483



 Score =  307 bits (787), Expect = 4e-83
 Identities = 228/762 (29%), Positives = 315/762 (41%), Gaps = 176/762 (23%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG----- 628
            + DEC     IC  GEC      Y C C PG+ + P    C+DV         PG     
Sbjct: 288  DIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVR--------PGYCYTA 339

Query: 629  --RGICMN----TGGSYNCHCNRGYRLHVGAGG-------RSCVDLNE-CAKPHLC---- 670
               G C N    +     C C+ G     G          R+  D N+ C+ P +     
Sbjct: 340  LTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRP 399

Query: 671  -------GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS----------- 712
                   G     +  P  +     PG ++   RPPV E +   R+P             
Sbjct: 400  EYPPPPLGPIPPVLPVPPGFP----PGPQIPVPRPPV-EYLYPSREPPRVLPVNVTDYCQ 454

Query: 713  -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFR 767
                 C +G+C   PGS +C  C  G++    G C DV+EC E +PC+ G C N  GS+ 
Sbjct: 455  LVRYLCQNGRCIPTPGSCRC-ECNKGFQLDLRGECIDVDEC-EKNPCAGGECINNQGSYT 512

Query: 768  CTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCED 826
            C C  GY        C D+DEC + G +C+NG C NT GSF C C +G+H++RD  +CED
Sbjct: 513  CQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED 572

Query: 827  IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKN 885
            +DEC     C+ G CIN +GS++C+C  G +L   GR C+DI+EC + P +C+ +G C N
Sbjct: 573  MDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINEC-ETPGICM-NGRCVN 630

Query: 886  LQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCC- 944
              GSY C C  G     D   C +    H +  CY  +     C   L   VT+ ECCC 
Sbjct: 631  TDGSYRCECFPGLAVGLDGRVCVDT---HMRSTCYGGYKRGQ-CIKPLFGAVTKSECCCA 686

Query: 945  SLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVN------------------- 985
            S    +G+ C+  PCP  +SAE+ +LC  G G T   + +N                   
Sbjct: 687  STEYAFGEPCQ--PCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRG 744

Query: 986  ---------YGIPAHR----DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL 1032
                     Y + +      DI+EC+L  S +C  G+C NT   + C C +GF Y  +L 
Sbjct: 745  TYKCICNSGYEVDSTGKNCVDINECVL-NSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLK 803

Query: 1033 ECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW 1092
             C D+DEC + S C NGVC+N+ G + C C+  +   P +  C+           +  CW
Sbjct: 804  TCEDIDEC-ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETI--------KGTCW 854

Query: 1093 SQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDT 1152
             Q   DG C   + G  L    CC   G  WG            S C   Q +       
Sbjct: 855  -QTVIDGRCEININGATLK-SQCCSSLGAAWG------------SPCTLCQVDP------ 894

Query: 1153 SPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1212
                                    + G+   R  G  CE               DIDEC 
Sbjct: 895  ------------------------ICGKGYSRIKGTQCE---------------DIDECE 915

Query: 1213 ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254
                   +CK+  CVNT GSF+C C +G         C+  R
Sbjct: 916  VFPG---VCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954



 Score =  254 bits (649), Expect = 4e-67
 Identities = 224/792 (28%), Positives = 309/792 (39%), Gaps = 142/792 (17%)

Query: 573  TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
            ++ +EC L+ +IC +G C      Y C CN GY      + CVD+NEC         G C
Sbjct: 722  SDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQC 781

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGY 691
             NT GS+ C C +G+        ++C D++EC + P +    G C N PG + C C    
Sbjct: 782  RNTPGSFVCTCPKGFIYKPDL--KTCEDIDECESSPCI---NGVCKNSPGSFICECSSES 836

Query: 692  RLKASRPPVCEDIDECRDPSSCPDGKCE-NKPGS---------------FKCIACQ---- 731
             L  ++  +C +  +     +  DG+CE N  G+                 C  CQ    
Sbjct: 837  TLDPTK-TICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPI 895

Query: 732  --PGYRSQGGGACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV- 786
               GY    G  C D++EC E  P  C  G C N  GSF+C C  G      GR CLD+ 
Sbjct: 896  CGKGYSRIKGTQCEDIDEC-EVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954

Query: 787  ---------DE----------------CEAG-----DVCDNGICSNTPGSFQCQCLSG-- 814
                     DE                C  G     + C+     NTP  ++  C  G  
Sbjct: 955  LETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTP-EYEELCPRGPG 1013

Query: 815  ---YHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDE 869
                 ++  +   +DI+EC   P+ C  G C NT GS++C C  G  L    R C DIDE
Sbjct: 1014 FATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDE 1073

Query: 870  CSQDPSLCLPHGACKNLQGSYVCVCDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            C   P LC   G C N  G + C CDEG+ +       C +++      EC     D + 
Sbjct: 1074 CRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMMKNCMDID------ECQ---RDPLL 1123

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHS-LCPDGK-----GYTQDNN 982
            C   +  N T+    C    G      I  C   +  E  + LCP+G+     G  Q   
Sbjct: 1124 CRGGVCHN-TEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCAC 1182

Query: 983  IVNYGIPAHR----DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVD 1038
               Y     R    DIDEC +       E  C N++  YEC C+ GF    +   C D+D
Sbjct: 1183 NPGYHSTPDRLFCVDIDECSIMNGGC--ETFCTNSEGSYECSCQPGFALMPDQRSCTDID 1240

Query: 1039 ECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWS---- 1093
            EC D  N C  G C N  G YRC C      S   + C+   E +  P   ++C S    
Sbjct: 1241 ECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNP---NICLSGTCE 1297

Query: 1094 ----------------QRGEDGMC-----------AGPLAGPALTFDDCCCRQGRGW--- 1123
                            ++G+ G              G  A    T     C    GW   
Sbjct: 1298 NTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGD 1357

Query: 1124 GAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVS 1178
            G +C        G+H  +  ++  +   +   L  +    +  +  D DEC      C +
Sbjct: 1358 GIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGN 1417

Query: 1179 GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCK 1238
            G+C+  PGG  CEC  GF   A    C DIDEC   N    +C    C N  G FRC C+
Sbjct: 1418 GQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPN----ICVFGTCHNLPGLFRCECE 1473

Query: 1239 AGFARSRPHGAC 1250
             G+   R  G C
Sbjct: 1474 IGYELDRSGGNC 1485



 Score =  239 bits (609), Expect = 2e-62
 Identities = 170/546 (31%), Positives = 236/546 (43%), Gaps = 57/546 (10%)

Query: 333  VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            V G     C +G++      C+DINECA   +     C+N  GSY C CP G+ L   R 
Sbjct: 2184 VIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRR 2243

Query: 393  QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFK 452
             C  D+ E +         + +C++ + T     +C C  G       + C  +     K
Sbjct: 2244 MC-KDEDECEEGKHDCTEKQMECKNLIGT----YMCICGPGYQRRPDGEGCVDENECQTK 2298

Query: 453  E-ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
              IC  G+    L +  + T +    F+                SP+Q    E  +   G
Sbjct: 2299 PGICENGR---CLNTRGSYTCECNDGFTA---------------SPNQ---DECLDNREG 2337

Query: 512  VTTDSPVSEERSVQQSHPTATTTPA---------RPYPELISRPSPPTMRWFLPDLPPSR 562
                  +     +  S+    T             P+ E+   P   T+  F    P  R
Sbjct: 2338 YCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEIC--PFQGTVA-FKKLCPHGR 2394

Query: 563  SAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA 622
              +    T   + DEC++  ++C +GECV     Y C C  GY        CVD+NEC  
Sbjct: 2395 GFM----TNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQ 2450

Query: 623  EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPG 681
             P  P   IC NT GSY C C +GY L     GRSC DL+ECA K H C     C+N  G
Sbjct: 2451 AP-KPCNFICKNTEGSYQCSCPKGYILQ--EDGRSCKDLDECATKQHNCQF--LCVNTIG 2505

Query: 682  HYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPD-GKCENKPGSFKCIACQPGYR-SQG 738
             + C C PG+         C D +EC  D + C   G C+N PGSF C  CQ G+   Q 
Sbjct: 2506 GFTCKCPPGF---TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTC-ECQRGFSLDQT 2561

Query: 739  GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG 798
            G +C DV+EC     C  G C+N+ G +RC+C QGY        C+D +EC +  +C   
Sbjct: 2562 GSSCEDVDECEGNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGA 2620

Query: 799  ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL 858
             C NT GS++C C +G+   +    C+DI+EC    A     C NT G Y C CP G+  
Sbjct: 2621 SCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFR 2680

Query: 859  VGGRKC 864
            +G   C
Sbjct: 2681 IGQGHC 2686



 Score =  234 bits (598), Expect = 3e-61
 Identities = 173/545 (31%), Positives = 227/545 (41%), Gaps = 91/545 (16%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGI 631
            + +EC  N  +C    CV     Y C C  GY      R C D +ECE     C   +  
Sbjct: 2206 DINECAQNPLLCAF-RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQME 2264

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690
            C N  G+Y C C  GY+      G  CVD NEC  KP +C + G C+N  G Y C C  G
Sbjct: 2265 CKNLIGTYMCICGPGYQRR--PDGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECNDG 2321

Query: 691  YRLKASRPP----------------VCEDIDECRDPSS----CPDG------KCENKPG- 723
            +    ++                  +C+     R+P +    C DG       CE  P  
Sbjct: 2322 FTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQ 2381

Query: 724  ---SFKCIACQPGYRSQGGGACRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPAPD 779
               +FK + C  G      GA  D++EC      C  G C N  GS+ C C  GY P   
Sbjct: 2382 GTVAFKKL-CPHGRGFMTNGA--DIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDIT 2438

Query: 780  GRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGG 839
            G SC+D++EC       N IC NT GS+QC C  GY L  D   C+D+DEC         
Sbjct: 2439 GTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQF 2498

Query: 840  DCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT 899
             C+NT G + C CP G        C D +EC+ D +LC   G C+N  GS+ C C  GF+
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQ-HHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFS 2557

Query: 900  PTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPC 959
              Q    CE+V++      C                    Q  C ++  G       Y C
Sbjct: 2558 LDQTGSSCEDVDECEGNHRC--------------------QHGCQNIIGG-------YRC 2590

Query: 960  PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
                       CP  +GY Q     +Y      D +EC+   + IC    C NT   Y+C
Sbjct: 2591 S----------CP--QGYLQ-----HYQWNQCVDENECL--SAHICGGASCHNTLGSYKC 2631

Query: 1020 YCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
             C  GF Y+     C D++EC   ++ C  G C NT GGY C C PP  +   Q  C+S 
Sbjct: 2632 MCPAGFQYEQFSGGCQDINECGSAQAPCSYG-CSNTEGGYLCGC-PPGYFRIGQGHCVSG 2689

Query: 1079 EEMER 1083
              M R
Sbjct: 2690 MGMGR 2694



 Score =  196 bits (498), Expect = 1e-49
 Identities = 196/752 (26%), Positives = 264/752 (35%), Gaps = 194/752 (25%)

Query: 572  VTETDECRLNQNICGHGECVPGP----PDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP 627
            V ET   R  +   G  + + GP      Y+ +C PG+++ P    C+ V  C    CG 
Sbjct: 34   VKETRASRAKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCI-VPICR-HSCGD 91

Query: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687
            G   C        C C  G ++    G RS    N       C +GG C +      C C
Sbjct: 92   G--FCSRPN---MCTCPSG-QIAPSCGSRSIQHCNI-----RCMNGGSCSDD----HCLC 136

Query: 688  YPGYRLKASRPPVCE----DIDECRDPSSCP------DGKCENKPGSFKCIACQPGYRSQ 737
              GY       PVCE    +   C  P+ C         +CE    +  C         Q
Sbjct: 137  QKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQ 196

Query: 738  G---GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GD 793
            G   G  C     CA         CE  P      C +G+ P     +C DVDEC+A   
Sbjct: 197  GQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPH-PCRRGFIPNIRTGACQDVDECQAIPG 255

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLC 852
            +C  G C NT GSF+C+C +G+ L+     CEDIDEC   P  C GG+C NT  SY C C
Sbjct: 256  LCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKC 315

Query: 853  PQG-HRLVGGRKCQDIDECSQDPSLC---LPHGACKNLQGSYVCVCDEGFTPTQDQHGCE 908
            P G +    G +C D+      P  C   L +G C N                       
Sbjct: 316  PPGFYTSPDGTRCIDV-----RPGYCYTALTNGRCSN----------------------- 347

Query: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP--CPVYSSAE 966
            ++ Q   K +C                       CC  G  W     + P  CP+ ++ +
Sbjct: 348  QLPQSITKMQC-----------------------CCDAGRCWSPGVTVAPEMCPIRATED 384

Query: 967  FHSLC------------------------------PDGKGYTQDNNIVNYGIPAHRD--- 993
            F+ LC                              P G         V Y  P+      
Sbjct: 385  FNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRV 444

Query: 994  -----IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048
                  D C L    +C+ G+C+ T     C C +GF  D    EC+DVDEC +++ C  
Sbjct: 445  LPVNVTDYCQLV-RYLCQNGRCIPTPGSCRCECNKGFQLDLR-GECIDVDEC-EKNPCAG 501

Query: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGP 1108
            G C N +G Y C C    + +  + +C   +E             Q G            
Sbjct: 502  GECINNQGSYTCQCRAGYQSTLTRTECRDIDEC-----------LQNGR----------- 539

Query: 1109 ALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSE 1168
                    C  GR        C       HC  +               G     +  + 
Sbjct: 540  -------ICNNGR--------CINTDGSFHCVCN--------------AGFHVTRDGKNC 570

Query: 1169 EDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224
            ED DEC     C++G C+   G   C C  GFQL +    C DI+EC        +C + 
Sbjct: 571  EDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPG----ICMNG 626

Query: 1225 RCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256
            RCVNT GS+RC C  G A       CV    R
Sbjct: 627  RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMR 658



 Score =  109 bits (272), Expect = 2e-23
 Identities = 66/189 (34%), Positives = 84/189 (44%), Gaps = 10/189 (5%)

Query: 570  TQVTETDECRLNQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGP 627
            T   + +EC  + N+CG  G C   P  ++C C  G+        C DV+ECE    C  
Sbjct: 2520 TSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQH 2579

Query: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687
            G   C N  G Y C C +GY  H       CVD NEC   H+CG G  C N  G YKC C
Sbjct: 2580 G---CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECLSAHICG-GASCHNTLGSYKCMC 2633

Query: 688  YPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNE 747
              G++ +      C+DI+EC    +     C N  G + C  C PGY   G G C     
Sbjct: 2634 PAGFQYEQFSGG-CQDINECGSAQAPCSYGCSNTEGGYLC-GCPPGYFRIGQGHCVSGMG 2691

Query: 748  CAEGSPCSP 756
               G+P  P
Sbjct: 2692 MGRGNPEPP 2700



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 53/165 (32%), Positives = 76/165 (46%), Gaps = 39/165 (23%)

Query: 335  GEVGADCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            G     C +GY+   +   C DINEC + P  C  G C N  GSYRC+CPPG+SL   + 
Sbjct: 1952 GSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKC 2011

Query: 393  QCIADKPEEKSLC-----------FRLVSPE-------------------------HQCQ 416
            + I +  EE  +C           F+ + PE                          +C 
Sbjct: 2012 EDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCS 2071

Query: 417  HPLTTRLTRQLCCCSV-GKAWGARCQRCPTDGTAAFKEICPAGKG 460
             P +   ++Q CCC++ G+ WG  C+ CPT+   AF++ICP G G
Sbjct: 2072 SPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSG 2116



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 65/228 (28%), Positives = 97/228 (42%), Gaps = 60/228 (26%)

Query: 277  GRCFQDTLPKQPCG----SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP 332
            G C+ D  P+   G    SN +     +  CC S+G AWG + C  CP +  +       
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWG-TPCEMCPAVNTS------- 1583

Query: 333  VRGEVGADCPQGYK-RLN--STHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGHSL- 387
               E    CP G   R N  +   +DI+EC  +PG+C+ G C+N  GS++C CP G+ L 
Sbjct: 1584 ---EYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLN 1640

Query: 388  ------------------GPSRTQ---------CIADKPE----------EKSLCFRLVS 410
                              GP             C  D  +           +SLC+R   
Sbjct: 1641 EDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYY 1700

Query: 411  PEHQ-CQHPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEIC 455
             ++Q C   L   +T+++CCCS  +G+AW   C++CP   T  F  +C
Sbjct: 1701 ADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLC 1748



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 51/162 (31%), Positives = 71/162 (43%), Gaps = 23/162 (14%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGE 336
            G+C ++T+    C  +    L  +E  C  I       +C   P L   G     P  G+
Sbjct: 1042 GKC-RNTIGSFKCRCDSGFALDSEERNCTDI------DECRISPDLCGRGQCVNTP--GD 1092

Query: 337  VGADCPQGYKR--LNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
                C +GY+   +   +C DI+EC   P +CR G C N  GSYRC CPPGH L P+ + 
Sbjct: 1093 FECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISA 1152

Query: 394  CIADKPEEKS--LCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
            CI     E S  LC     P  +C       + +  C C+ G
Sbjct: 1153 CIDINECELSAHLC-----PNGRC----VNLIGKYQCACNPG 1185



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 39/127 (30%), Positives = 53/127 (41%), Gaps = 17/127 (13%)

Query: 289  CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL 348
            C S      +KQE CC   G  WG   C  CP        +P     ++   CP G   +
Sbjct: 2070 CSSPKSRNHSKQECCCALKGEGWGDP-CELCPT-------EPDEAFRQI---CPYGSGII 2118

Query: 349  --NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR----TQCIADKPEEK 402
                    D++EC  P VC+HG C+N  GSYRC CP G+ L  +      +C    P   
Sbjct: 2119 VGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGN 2178

Query: 403  SLCFRLV 409
              C  ++
Sbjct: 2179 GTCKNVI 2185



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 41/121 (33%), Positives = 57/121 (47%), Gaps = 16/121 (13%)

Query: 277  GRCFQDTLPKQ-PCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335
            G CF + L      GS+    +TK E CC   G  WG   C  CP       +K      
Sbjct: 2337 GYCFTEVLQNMCQIGSSNRNPVTKSECCCDG-GRGWGPH-CEICPFQGTVAFKKL----- 2389

Query: 336  EVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
                 CP G  R   T+  DI+EC  +  VCR+G+C+N+ GSY C+C  G++   + T C
Sbjct: 2390 -----CPHG--RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSC 2442

Query: 395  I 395
            +
Sbjct: 2443 V 2443



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 1/72 (1%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            G    DC  GY+  ++  C D NEC  +P +C HG C++  GS+ C+C  G      +T 
Sbjct: 1829 GSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTM 1888

Query: 394  CIADKPEEKSLC 405
            C+     E+  C
Sbjct: 1889 CLDINECERDAC 1900



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 45/146 (30%), Positives = 60/146 (41%), Gaps = 40/146 (27%)

Query: 287  QPCGSNPLPGLTKQEDCCG-SIGTAWGQSKCHKCPQ------LQYTGVQKPG-------- 331
            Q C    L  +TK+  CC  +IG AW +  C +CP           G Q+PG        
Sbjct: 1704 QTCDGELLFNMTKKMCCCSYNIGRAWNKP-CEQCPIPSTDEFATLCGSQRPGFVIDIYTG 1762

Query: 332  -PVR--------------------GEVGADCPQGYKRLNSTH-CQDINECAMPGVC-RHG 368
             PV                     G    +CP G+   +    C+DI+EC    VC R+ 
Sbjct: 1763 LPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNA 1822

Query: 369  DCLNNPGSYRCVCPPGHSLGPSRTQC 394
            +C+N  GSYRC C PG+    S  QC
Sbjct: 1823 ECINTAGSYRCDCKPGYRF-TSTGQC 1847



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 13/83 (15%)

Query: 304  CGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGY-KRLNSTHCQDINECAM 361
            C  +    G  +C H C             + G     CPQGY +      C D NEC  
Sbjct: 2565 CEDVDECEGNHRCQHGCQN-----------IIGGYRCSCPQGYLQHYQWNQCVDENECLS 2613

Query: 362  PGVCRHGDCLNNPGSYRCVCPPG 384
              +C    C N  GSY+C+CP G
Sbjct: 2614 AHICGGASCHNTLGSYKCMCPAG 2636



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 19/75 (25%)

Query: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126
           C   C+ G  C D    CQ+G   T  G+                VC   C+NGG+C + 
Sbjct: 119 CNIRCMNGGSCSDDHCLCQKGYIGTHCGQP---------------VCESGCLNGGRCVAP 163

Query: 127 NQCLCPPDFTGRFCQ 141
           N+C C   FTG  C+
Sbjct: 164 NRCACTYGFTGPQCE 178



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 35/118 (29%), Positives = 43/118 (36%), Gaps = 11/118 (9%)

Query: 46  AGERGAGGGGAL-----ARERFKVVFAP----VICKRTCLKGQCRDSCQQGSNMTLIGEN 96
           A  RG GG  AL        R+     P    +     C+   CR SC  G         
Sbjct: 42  AKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCT 101

Query: 97  GHSTDTLTGSGFRVVV-CPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGG 153
             S       G R +  C + CMNGG CS  + CLC   + G  C  P   +G   GG
Sbjct: 102 CPSGQIAPSCGSRSIQHCNIRCMNGGSCSD-DHCLCQKGYIGTHCGQPVCESGCLNGG 158



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 2/48 (4%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            C  G+K  +  T C DINEC     C +G C N  GS+ C C  G  L
Sbjct: 1876 CHTGFKTNDDQTMCLDINECERDA-CGNGTCRNTIGSFNCRCNHGFIL 1922


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  441 bits (1135), Expect = e-123
 Identities = 308/998 (30%), Positives = 426/998 (42%), Gaps = 158/998 (15%)

Query: 292  NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST 351
            +P+PG  + + CC ++G AWG ++C +CP        KPG    E    CP+G    N  
Sbjct: 1014 HPVPGKFRMDACCCAVGAAWG-TECEECP--------KPGTKEYETL--CPRGAGFANRG 1062

Query: 352  HC-------QDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEE 401
                     +DINEC A PG+C +G C N  GS++C C  G +L      C  I +    
Sbjct: 1063 DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS 1122

Query: 402  KSLCFRLV------SPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT---DGTAAFK 452
              LC   +      S E +C     +       C  + +     C+R P     GT    
Sbjct: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDE-----CERNPLLCRGGTCVNT 1177

Query: 453  E---ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509
            E    C    G+ +  S +      E   S  L  +G           S  P  + T + 
Sbjct: 1178 EGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDR 1237

Query: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            +G T    + E   +     T  T     Y    S             +P  RS  +I  
Sbjct: 1238 QGCTD---IDECMIMNGGCDTQCTNSEGSYECSCSEGYAL--------MPDGRSCADI-- 1284

Query: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
                  DEC  N +IC  G+C   P +Y C C  G+ +    + C+DVNEC+        
Sbjct: 1285 ------DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688
            G C NT GS+ CHC  GY +  G  G  C D++EC    H C     C+N PG +KC+C 
Sbjct: 1339 GECENTKGSFICHCQLGYSVKKGTTG--CTDVDECEIGAHNCDMHASCLNIPGSFKCSCR 1396

Query: 689  PGYRLKASRPPVCEDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746
             G+     +   C D+DEC + +  C  + +C N PGS++C AC  G+   G   C DV+
Sbjct: 1397 EGWIGNGIK---CIDLDECSNGTHQCSINAQCVNTPGSYRC-ACSEGFTGDGF-TCSDVD 1451

Query: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805
            ECAE  + C  G C N+PG++RC C  G+ PA D RSC D+DEC   ++C  G C+N PG
Sbjct: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG 1511

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
             F C C  GY L R   +C DIDEC  P  C+ G C+NT G Y C CP   +L       
Sbjct: 1512 MFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQL------- 1564

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923
                         P G                        GC +    +    CYL F  
Sbjct: 1565 ------------NPTGV-----------------------GCVD----NRVGNCYLKFGP 1585

Query: 924  --DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981
              D ++ C++ +   V++  CCCSLG  WG+ CE   CP  +S E+++LCP G+G+  + 
Sbjct: 1586 RGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE--TCPPVNSTEYYTLCPGGEGFRPNP 1643

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL 1041
              +        DIDEC      +C+ G C+NT   ++C C QG+Y   +   C D+DEC 
Sbjct: 1644 ITI-----ILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECF 1697

Query: 1042 DESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGM 1100
                 C  G C NT G Y C C P          C+          R+  C+  R  +G 
Sbjct: 1698 AHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD--------MRKSFCY--RSYNGT 1747

Query: 1101 CAGPLAGPALTFDDCCC--RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLG 1158
                     +T   CCC    G+ W   C PCP  G         +     +D       
Sbjct: 1748 TCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDI------ 1801

Query: 1159 KPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213
                       D DEC+     C +G C+ + G   CECP GF  +     C DIDEC  
Sbjct: 1802 -----HTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS- 1855

Query: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
             N   L  ++  C+N+ GS+RC C AGF  S P+GACV
Sbjct: 1856 -NGDNLCQRNADCINSPGSYRCECAAGFKLS-PNGACV 1891



 Score =  410 bits (1054), Expect = e-114
 Identities = 256/783 (32%), Positives = 359/783 (45%), Gaps = 136/783 (17%)

Query: 566  EIAPTQ--VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE 623
            E++P++    + +EC L+ N+C +G+CV     Y C CNPGY++ P  + C D++EC   
Sbjct: 1190 ELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIM 1249

Query: 624  PCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGH 682
              G     C N+ GSY C C+ GY L     GRSC D++EC   P +C DGG C N PG 
Sbjct: 1250 NGGCDTQ-CTNSEGSYECSCSEGYALM--PDGRSCADIDECENNPDIC-DGGQCTNIPGE 1305

Query: 683  YKCNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYR-SQGGG 740
            Y+C CY G+ + +     C D++EC   S+ C  G+CEN  GSF C  CQ GY   +G  
Sbjct: 1306 YRCLCYDGF-MASMDMKTCIDVNECDLNSNICMFGECENTKGSFIC-HCQLGYSVKKGTT 1363

Query: 741  ACRDVNECAEGS------------------PCSPGW------------------------ 758
             C DV+EC  G+                   C  GW                        
Sbjct: 1364 GCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINA 1423

Query: 759  -CENLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYH 816
             C N PGS+RC C++G+    DG +C DVDEC E  ++C+NG C N PG+++C+C  G+ 
Sbjct: 1424 QCVNTPGSYRCACSEGFTG--DGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481

Query: 817  LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPS 875
             + D   C+DIDEC F   C+ G C N  G + C+C  G+ L   G  C DIDEC+ DP 
Sbjct: 1482 PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPI 1540

Query: 876  LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF----DDTVFCDS 931
             C+ +G C N  G Y C C   F       GC +    +    CYL F    D ++ C++
Sbjct: 1541 NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVD----NRVGNCYLKFGPRGDGSLSCNT 1595

Query: 932  VLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAH 991
             +   V++  CCCSLG  WG+ CE   CP  +S E+++LCP G+G+  +   +       
Sbjct: 1596 EIGVGVSRSSCCCSLGKAWGNPCET--CPPVNSTEYYTLCPGGEGFRPNPITIIL----- 1648

Query: 992  RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNGV 1050
             DIDEC      +C+ G C+NT   ++C C QG+Y   +   C D+DEC      C  G 
Sbjct: 1649 EDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT 1707

Query: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPAL 1110
            C NT G Y C C P          C+          R+  C+  R  +G          +
Sbjct: 1708 CYNTLGNYTCICPPEYMQVNGGHNCMDM--------RKSFCY--RSYNGTTCENELPFNV 1757

Query: 1111 TFDDCCCRQ--GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSE 1168
            T   CCC    G+ W   C PCP  G         +     +D   +  GK    ++  E
Sbjct: 1758 TKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFD---IHTGKAVDIDECKE 1814

Query: 1169 ----------------------------------EDSDECR-----CV-SGRCVPRPGGA 1188
                                              ED DEC      C  +  C+  PG  
Sbjct: 1815 IPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSY 1874

Query: 1189 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248
             CEC  GF+L  + A CVD +EC E+     +C    CV+  GS++C+C  GF  S+   
Sbjct: 1875 RCECAAGFKLSPNGA-CVDRNECLEIPN---VCSHGLCVDLQGSYQCICHNGFKASQDQT 1930

Query: 1249 ACV 1251
             C+
Sbjct: 1931 MCM 1933



 Score =  388 bits (996), Expect = e-107
 Identities = 233/709 (32%), Positives = 325/709 (45%), Gaps = 93/709 (13%)

Query: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRS-HPQHRYCVDVNECEA 622
            A+++     T+ DECR++ ++CG G CV  P  + C C  GY S     + C+D++ECE 
Sbjct: 1105 ALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECER 1164

Query: 623  EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPG 681
             P     G C+NT GS+ C C  G+ L        CVD+NEC+   +LC +G  C+N  G
Sbjct: 1165 NPLLCRGGTCVNTEGSFQCDCPLGHEL--SPSREDCVDINECSLSDNLCRNGK-CVNMIG 1221

Query: 682  HYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG- 740
             Y+C+C PGY+    R   C DIDEC   +   D +C N  GS++C +C  GY     G 
Sbjct: 1222 TYQCSCNPGYQATPDRQG-CTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGYALMPDGR 1279

Query: 741  ACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDN 797
            +C D++EC E +P  C  G C N+PG +RC C  G+  + D ++C+DV+EC+   ++C  
Sbjct: 1280 SCADIDEC-ENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338

Query: 798  GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA--ACIGGDCINTNGSYRCLCPQG 855
            G C NT GSF C C  GY + +  + C D+DEC+  A    +   C+N  GS++C C +G
Sbjct: 1339 GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398

Query: 856  HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
              +  G KC D+DECS     C  +  C N  GSY C C EGFT   D   C +V+    
Sbjct: 1399 W-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTG--DGFTCSDVD---- 1451

Query: 916  KKECYLNFDDTVFCDSVLATNVT-QQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDG 974
              EC  N +    C++    NV     C C +G              ++ A     C   
Sbjct: 1452 --ECAENIN---LCENGQCLNVPGAYRCECEMG--------------FTPASDSRSC--- 1489

Query: 975  KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC 1034
                             +DIDEC      IC  G C N    + C C  G+  D     C
Sbjct: 1490 -----------------QDIDECSF--QNICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530

Query: 1035 VDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW-- 1092
             D+DEC D  NC NG+C NT G Y C C P  + +P    C+          R   C+  
Sbjct: 1531 TDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD--------NRVGNCYLK 1582

Query: 1093 -SQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1151
               RG+  +      G  ++   CCC  G+ WG  C  CPP             S  ++ 
Sbjct: 1583 FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPP-----------VNSTEYYT 1631

Query: 1152 TSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCV 1206
              P   G  P       ED DEC+     C  G C+   G   CECP G+ L      C 
Sbjct: 1632 LCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE 1691

Query: 1207 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255
            DIDEC      G +C    C NT G++ C+C   + +      C+  R+
Sbjct: 1692 DIDEC--FAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRK 1737



 Score =  356 bits (914), Expect = 7e-98
 Identities = 221/674 (32%), Positives = 304/674 (45%), Gaps = 82/674 (12%)

Query: 592  PGPPDYSCHCN--PGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRL 649
            PG  D+   C   PG+         VD++EC+  P     G+C+N  GS+ C C  G+  
Sbjct: 1782 PGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSY 1841

Query: 650  HVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
            +       C D++EC+   +LC     CIN PG Y+C C  G++L  +    C D +EC 
Sbjct: 1842 NDLL--LVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG--ACVDRNECL 1897

Query: 709  D-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSF 766
            + P+ C  G C +  GS++CI C  G++ SQ    C DV+EC E  PC  G C+N  GS+
Sbjct: 1898 EIPNVCSHGLCVDLQGSYQCI-CHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSY 1955

Query: 767  RCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC 824
             C C  G+        CLD+DEC +  G VC NG C N  GSF+C C  GY L+ D  +C
Sbjct: 1956 NCLCYPGFE-LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC 2014

Query: 825  EDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGAC 883
             D +EC   P +C  G C N  GS+RC+CP G+  V    C DI+EC +DP++CL  G+C
Sbjct: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE-VKSENCIDINECDEDPNICL-FGSC 2072

Query: 884  KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECC 943
             N  G + C+C  GF  + +   C +  Q      C+ NF++   C    A N T+ +CC
Sbjct: 2073 TNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF----CFTNFENGK-CSVPKAFNTTKAKCC 2127

Query: 944  CSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001
            CS   G GWGD CE+  CP      F  LCP G G     +          D++EC L  
Sbjct: 2128 CSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGTVPSLH------DTREDVNEC-LES 2178

Query: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCA 1061
              IC  G+C+NT   + C C  G+  D   + CVD DEC   + C NG C N  G + C 
Sbjct: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN 2238

Query: 1062 CTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGR 1121
            C    E  P    C    E  + P              +CA        +++ C C  G 
Sbjct: 2239 CNEGFEPGPMMN-CEDINECAQNPL-------------LCAFRCMNTFGSYE-CTCPIGY 2283

Query: 1122 GWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1181
                  + C                               +D D   E   +C      C
Sbjct: 2284 ALREDQKMC-------------------------------KDLDECAEGLHDCESRGMMC 2312

Query: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
                G  +C CP G         CVD +ECR    +  +C++ RCVN  GS+RC C  GF
Sbjct: 2313 KNLIGTFMCICPPGMARRPDGEGCVDENECRT---KPGICENGRCVNIIGSYRCECNEGF 2369

Query: 1242 ARSRPHGACVPQRR 1255
              S     C+  R+
Sbjct: 2370 QSSSSGTECLDNRQ 2383



 Score =  347 bits (891), Expect = 3e-95
 Identities = 244/760 (32%), Positives = 320/760 (42%), Gaps = 129/760 (16%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGP---- 627
            + +EC LN NIC  GEC      + CHC  GY        C DV+ECE  A  C      
Sbjct: 1325 DVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASC 1384

Query: 628  ----------------GRGI--------------------CMNTGGSYNCHCNRGYRLHV 651
                            G GI                    C+NT GSY C C+ G+    
Sbjct: 1385 LNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--- 1441

Query: 652  GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS 711
               G +C D++ECA+     + G C+N PG Y+C C  G+   AS    C+DIDEC   +
Sbjct: 1442 -GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT-PASDSRSCQDIDECSFQN 1499

Query: 712  SCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC 770
             C  G C N PG F CI C  GY   + GG C D++ECA+   C  G C N PG + C C
Sbjct: 1500 ICVFGTCNNLPGMFHCI-CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNC 1558

Query: 771  AQGYAPAPDGRSCLD--VDEC--EAGDVCDNGICSNTP-----GSFQCQCLSGYHLSRDR 821
               +   P G  C+D  V  C  + G   D  +  NT          C C  G       
Sbjct: 1559 PPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPC 1618

Query: 822  SHC---------------------------EDIDEC-DFPAACIGGDCINTNGSYRCLCP 853
              C                           EDIDEC + P  C GG+CINT GS++C CP
Sbjct: 1619 ETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECP 1678

Query: 854  QGHRLVGG-RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
            QG+ L    R C+DIDEC   P +C P G C N  G+Y C+C   +      H C ++  
Sbjct: 1679 QGYYLSEDTRICEDIDECFAHPGVCGP-GTCYNTLGNYTCICPPEYMQVNGGHNCMDMR- 1736

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCS--LGAGWGDHCEIYPCPVYSSAEFHSL 970
               K  CY +++ T  C++ L  NVT++ CCC+  +G  W   CE  PCP   +A+F ++
Sbjct: 1737 ---KSFCYRSYNGTT-CENELPFNVTKRMCCCTYNVGKAWNKPCE--PCPTPGTADFKTI 1790

Query: 971  CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN 1030
            C +  G+T D   ++ G     DIDEC      IC  G C+N    + C C  GF Y+  
Sbjct: 1791 CGNIPGFTFD---IHTGKAV--DIDECKEIPG-ICANGVCINQIGSFRCECPTGFSYNDL 1844

Query: 1031 LLECVDVDECLDESNC--RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERR 1088
            LL C D+DEC +  N   RN  C N+ G YRC C    + SP    C+   E    P   
Sbjct: 1845 LLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSP-NGACVDRNECLEIP--- 1900

Query: 1089 DVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE-SN 1147
            +VC       G+C   L G       C C  G         C         P       N
Sbjct: 1901 NVC-----SHGLCV-DLQGSY----QCICHNGFKASQDQTMCMDVDECERHPCGNGTCKN 1950

Query: 1148 SFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRCVPRPGGAVCECPGGFQLDAS 1201
            +    + L         ++   D DEC       C +GRC    G   C C  G++L   
Sbjct: 1951 TVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPD 2010

Query: 1202 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
               C+D +EC  L      C    C N  GSFRC+C  G+
Sbjct: 2011 GKNCIDTNECVALPGS---CSPGTCQNLEGSFRCICPPGY 2047



 Score =  344 bits (882), Expect = 3e-94
 Identities = 228/727 (31%), Positives = 319/727 (43%), Gaps = 99/727 (13%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            +T+EC      C  G C      + C C PGY    ++  C+D+NEC+ +P     G C 
Sbjct: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE-----------CAKPHLCGDGGF---CINF 679
            NT G + C C  G+ L     GR C D  +           C+ P           C   
Sbjct: 2074 NTPGGFQCLCPPGFVL--SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131

Query: 680  PGH----------------YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722
            PG                 ++  C  G+    S     ED++EC + P  C +G+C N  
Sbjct: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191

Query: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781
            GSF+C  C  GY     G  C D +EC+ G+PC  G C N+ GSF C C +G+ P P   
Sbjct: 2192 GSFRC-ECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM-M 2249

Query: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838
            +C D++EC    +     C NT GS++C C  GY L  D+  C+D+DEC          G
Sbjct: 2250 NCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRG 2309

Query: 839  GDCINTNGSYRCLCPQGH-RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
              C N  G++ C+CP G  R   G  C D +EC   P +C  +G C N+ GSY C C+EG
Sbjct: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368

Query: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN-VTQQECCCSLGAGWGDHCEI 956
            F  +     C +  Q      C+     T+   +  + N VT+ ECCC  G GWG  CE+
Sbjct: 2369 FQSSSSGTECLDNRQGL----CFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424

Query: 957  YPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPG 1016
              CP+  +A++  +CP G GYT D           RDIDEC +  + +C  G+C+NT   
Sbjct: 2425 --CPLPGTAQYKKICPHGPGYTTDG----------RDIDECKVMPN-LCTNGQCINTMGS 2471

Query: 1017 YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL 1076
            + C+CK G+  D +   C+D+DEC       N +C+NT G Y+C+C          + C 
Sbjct: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK 2531

Query: 1077 SPEEMERAPERRDVCWSQRGEDGMCAGPLAG------PALTFDDCCCRQGRGWGAQCRPC 1130
              +E +           Q     +C   L G      P  T     C      G+Q   C
Sbjct: 2532 DLDECQT---------KQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLC 2582

Query: 1131 PPRGAGSHCPTSQS---ESNSFWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVP 1183
              +G   + P S S   +     D + L           + ED DEC    RC  G C  
Sbjct: 2583 GAKGICQNTPGSFSCECQRGFSLDATGL-----------NCEDVDECDGNHRCQHG-CQN 2630

Query: 1184 RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFAR 1243
              GG  C CP G+       +CVD +EC   N     C S  C NT GS++C C +GF+ 
Sbjct: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPN----ACGSASCYNTLGSYKCACPSGFSF 2686

Query: 1244 SRPHGAC 1250
             +   AC
Sbjct: 2687 DQFSSAC 2693



 Score =  318 bits (815), Expect = 2e-86
 Identities = 216/716 (30%), Positives = 309/716 (43%), Gaps = 108/716 (15%)

Query: 566  EIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEP 624
            +I   +  + DEC+    IC +G C+     + C C  G+  +     C D++EC   + 
Sbjct: 1800 DIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDN 1859

Query: 625  CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHY 683
                   C+N+ GSY C C  G++L   +   +CVD NEC + P++C   G C++  G Y
Sbjct: 1860 LCQRNADCINSPGSYRCECAAGFKL---SPNGACVDRNECLEIPNVCSH-GLCVDLQGSY 1915

Query: 684  KCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR 743
            +C C+ G++    +  +C D+DEC +   C +G C+N  GS+ C+ C PG+       C 
Sbjct: 1916 QCICHNGFKASQDQ-TMCMDVDEC-ERHPCGNGTCKNTVGSYNCL-CYPGFELTHNNDCL 1972

Query: 744  DVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGIC 800
            D++EC+   G  C  G C N  GSF+C C +GY   PDG++C+D +EC A    C  G C
Sbjct: 1973 DIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTC 2032

Query: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLV 859
             N  GSF+C C  GY +  +  +C DI+ECD  P  C+ G C NT G ++CLCP G  L 
Sbjct: 2033 QNLEGSFRCICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLS 2090

Query: 860  -GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
              GR+C D                                                 +  
Sbjct: 2091 DNGRRCFDT-----------------------------------------------RQSF 2103

Query: 919  CYLNFDDTVFCDSVLATNVTQQECCCSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKG 976
            C+ NF++   C    A N T+ +CCCS   G GWGD CE+  CP      F  LCP G G
Sbjct: 2104 CFTNFENGK-CSVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHG 2160

Query: 977  YTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVD 1036
                 +          D++EC L    IC  G+C+NT   + C C  G+  D   + CVD
Sbjct: 2161 TVPSLH------DTREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVD 2213

Query: 1037 VDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRG 1096
             DEC   + C NG C N  G + C C    E  P    C    E  + P           
Sbjct: 2214 TDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQNPLLCAFRCMNTF 2272

Query: 1097 EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1156
                C  P+ G AL  D   C+           C  RG        ++   +F    P  
Sbjct: 2273 GSYECTCPI-GYALREDQKMCKDLDECAEGLHDCESRGM-----MCKNLIGTFMCICPPG 2326

Query: 1157 LGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDE- 1210
            + + P  E   +E  +ECR     C +GRCV   G   CEC  GFQ  +S   C+D  + 
Sbjct: 2327 MARRPDGEGCVDE--NECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQG 2384

Query: 1211 ----------CR-ELNQRGLLCKSERCVNTSGSFRCVCK-------AGFARSRPHG 1248
                      C+   + R L+ KSE C +    +   C+       A + +  PHG
Sbjct: 2385 LCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHG 2440



 Score =  315 bits (806), Expect = 2e-85
 Identities = 231/769 (30%), Positives = 315/769 (40%), Gaps = 181/769 (23%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC    N+C HG CV     Y C C+ G+++      C+DV+ECE  PCG   G C 
Sbjct: 1892 DRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCG--NGTCK 1949

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK--PHLCGDGGFCINFPGHYKCNCYPGY 691
            NT GSYNC C  G+ L        C+D++EC+     +C +G  C N  G +KC C  GY
Sbjct: 1950 NTVGSYNCLCYPGFEL---THNNDCLDIDECSSFFGQVCRNGR-CFNEIGSFKCLCNEGY 2005

Query: 692  RLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAE 750
             L       C D +EC   P SC  G C+N  GSF+CI C PGY  +    C D+NEC E
Sbjct: 2006 ELTPDGKN-CIDTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSEN-CIDINECDE 2062

Query: 751  G-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG----------- 798
              + C  G C N PG F+C C  G+  + +GR C D  +       +NG           
Sbjct: 2063 DPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTT 2122

Query: 799  ----ICSNTPG----------------SFQCQCLSGY------HLSRDRSHCEDIDEC-D 831
                 CS  PG                +FQ  C  G+      H +R     ED++EC +
Sbjct: 2123 KAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTR-----EDVNECLE 2177

Query: 832  FPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890
             P  C  G CINT+GS+RC CP G+ L   G +C D DECS        +G C N+ GS+
Sbjct: 2178 SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC--GNGTCTNVIGSF 2235

Query: 891  VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW 950
             C C+EGF P    + CE++       EC  N    + C           EC C +G   
Sbjct: 2236 ECNCNEGFEPGPMMN-CEDIN------ECAQN---PLLCAFRCMNTFGSYECTCPIG--- 2282

Query: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-- 1008
                       Y+  E   +C                    +D+DEC   G   C+    
Sbjct: 2283 -----------YALREDQKMC--------------------KDLDECAE-GLHDCESRGM 2310

Query: 1009 KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAE 1067
             C N    + C C  G     +   CVD +EC  +   C NG C N  G YRC C    +
Sbjct: 2311 MCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQ 2370

Query: 1068 YSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1127
             S +  +CL          R+ +C+++  +        +   +T  +CCC  GRGWG QC
Sbjct: 2371 SSSSGTECLD--------NRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422

Query: 1128 RPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG 1179
              CP  G   +   CP     +                   +   D DEC+     C +G
Sbjct: 2423 ELCPLPGTAQYKKICPHGPGYT-------------------TDGRDIDECKVMPNLCTNG 2463

Query: 1180 RCVPRPGGAVCECPGGFQLDASRARCVDIDECRE-------------------------L 1214
            +C+   G   C C  G+  D S   C+D+DEC +                         L
Sbjct: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVL 2523

Query: 1215 NQRGLLCKSER------------CVNTSGSFRCVCKAGFARSRPHGACV 1251
             + G  CK               CVNT G F C C  GF  ++ H AC+
Sbjct: 2524 QEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--TQHHTACI 2570



 Score =  296 bits (759), Expect = 6e-80
 Identities = 233/759 (30%), Positives = 304/759 (40%), Gaps = 146/759 (19%)

Query: 562  RSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDV---- 617
            R    I      + +EC +   +C +G CV     + C C  G       R C+D+    
Sbjct: 943  RGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ 1002

Query: 618  -----NECEAEPCGPGR----GICMNTGGSYNCHC----------------------NRG 646
                 +E E     PG+      C   G ++   C                      NRG
Sbjct: 1003 CYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRG 1062

Query: 647  YRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
                V  G     D+NEC A P +C   G C N  G +KC C  G+ L       C DID
Sbjct: 1063 ---DVLTGRPFYKDINECKAFPGMC-TYGKCRNTIGSFKCRCNSGFALDMEERN-CTDID 1117

Query: 706  ECR-DPSSCPDGKCENKPGSFKCIACQPGYRS--QGGGACRDVNECAEGSP--CSPGWCE 760
            ECR  P  C  G C N PGSF+C  C  GY S       C D++EC E +P  C  G C 
Sbjct: 1118 ECRISPDLCGSGICVNTPGSFEC-ECFEGYESGFMMMKNCMDIDEC-ERNPLLCRGGTCV 1175

Query: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNGICSNTPGSFQCQCLSGYHLSR 819
            N  GSF+C C  G+  +P    C+D++EC   D +C NG C N  G++QC C  GY  + 
Sbjct: 1176 NTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATP 1235

Query: 820  DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCL 878
            DR  C DIDEC          C N+ GSY C C +G+ L+  GR C DIDEC  +P +C 
Sbjct: 1236 DRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDIC- 1294

Query: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF--CDSVLATN 936
              G C N+ G Y C+C +GF  + D   C +V       EC LN +  +F  C++   + 
Sbjct: 1295 DGGQCTNIPGEYRCLCYDGFMASMDMKTCIDV------NECDLNSNICMFGECENTKGSF 1348

Query: 937  VTQQECCCSLGAGWG---------DHCEI--YPCPVYSS-----AEFHSLCPDGKGYTQD 980
            +    C C LG             D CEI  + C +++S       F   C +G      
Sbjct: 1349 I----CHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG------ 1398

Query: 981  NNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1040
               +  GI    D+DEC     +     +CVNT   Y C C +GF  DG    C DVDEC
Sbjct: 1399 --WIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDG--FTCSDVDEC 1453

Query: 1041 LDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDG 1099
             +  N C NG C N  G YRC C              +P    R+ +  D C  Q     
Sbjct: 1454 AENINLCENGQCLNVPGAYRCEC----------EMGFTPASDSRSCQDIDECSFQ----N 1499

Query: 1100 MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGK 1159
            +C             C C  G               G +C                    
Sbjct: 1500 ICVFGTCNNLPGMFHCICDDGYELDR---------TGGNC-------------------- 1530

Query: 1160 PPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVD--IDEC-RELNQ 1216
                    +E +D   CV+G CV  PG   C CP  FQL+ +   CVD  +  C  +   
Sbjct: 1531 -----TDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGP 1585

Query: 1217 RG---LLCKSERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            RG   L C +E  V  S S  C C  G A   P   C P
Sbjct: 1586 RGDGSLSCNTEIGVGVSRS-SCCCSLGKAWGNPCETCPP 1623



 Score =  293 bits (751), Expect = 5e-79
 Identities = 187/589 (31%), Positives = 253/589 (42%), Gaps = 118/589 (20%)

Query: 702  EDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760
            + ID C+  ++ C +G+C     S++C  C  GY+    G C DV+EC   +PC+ G C 
Sbjct: 493  QTIDICKHHANLCLNGRCIPTVSSYRC-ECNMGYKQDANGDCIDVDECTS-NPCTNGDCV 550

Query: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819
            N PGS+ C C  G+   P  ++C+D+DEC + G +C NG C NT GSFQC C +G+ L+ 
Sbjct: 551  NTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610

Query: 820  DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCL 878
            D  +C D DEC     C+ G CIN +GS++C+C  G  L   GR C D+DEC Q P +C+
Sbjct: 611  DGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICM 669

Query: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVT 938
             +G C N +GS+ C C  G     D   C +    H +  CY      V C       VT
Sbjct: 670  -NGHCINSEGSFRCDCPPGLAVGMDGRVCVDT---HMRSTCYGGIKKGV-CVRPFPGAVT 724

Query: 939  QQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
            + ECCC+    G+G+ C+  PCP  +SAEFH LC  G G T D           RDI+EC
Sbjct: 725  KSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITVDG----------RDINEC 772

Query: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL-DESNCRNGVCENTRG 1056
             L   +IC  G C N +  Y C C  G+  D +   C+D+DECL +   C NG+C NT G
Sbjct: 773  AL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 831

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRG-------------------- 1096
             Y C C P   +      C    E E  P     C +  G                    
Sbjct: 832  SYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICI 891

Query: 1097 -----------EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE 1145
                       +D  C   + G  L   +CC   G  WG+   PC      + CP     
Sbjct: 892  DSLKGTCWLNIQDSRCEVNINGATLK-SECCATLGAAWGS---PCERCELDTACP----- 942

Query: 1146 SNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARC 1205
                                              R + R  G  CE              
Sbjct: 943  ----------------------------------RGLARIKGVTCE-------------- 954

Query: 1206 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254
             D++EC        +C + RCVN+ GSF C C  G         C+  R
Sbjct: 955  -DVNECEVFPG---VCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIR 999



 Score =  255 bits (651), Expect = 2e-67
 Identities = 222/804 (27%), Positives = 309/804 (38%), Gaps = 168/804 (20%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + +EC L+ +IC +G C      Y C+CN GY      R C+D++EC         G+C 
Sbjct: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCR 827

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693
            NT GSY+C C  GY         +C D+NEC + + C +G  C N  G + C C PG +L
Sbjct: 828  NTPGSYSCTCPPGYVFRTET--ETCEDINEC-ESNPCVNGA-CRNNLGSFNCECSPGSKL 883

Query: 694  KASRPPVCEDIDECRDPSSCPDGKCE-NKPGSF------------------KC---IACQ 731
             +S   +C D  +     +  D +CE N  G+                   +C    AC 
Sbjct: 884  -SSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACP 942

Query: 732  PGYRSQGGGACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789
             G     G  C DVNEC E  P  C  G C N  GSF C C +G      GR CLD+   
Sbjct: 943  RGLARIKGVTCEDVNEC-EVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001

Query: 790  EAGDVCDNGICSN-TPGSFQ---CQCLSGYHLSRDRSHC--------------------- 824
            +     D   C +  PG F+   C C  G     +   C                     
Sbjct: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061

Query: 825  ----------EDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQ 872
                      +DI+EC  FP  C  G C NT GS++C C  G  L +  R C DIDEC  
Sbjct: 1062 GDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRI 1121

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGF-TPTQDQHGCEEVEQPHH-----KKECYLNFDDT 926
             P LC   G C N  GS+ C C EG+ +       C ++++        +    +N + +
Sbjct: 1122 SPDLC-GSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGS 1180

Query: 927  VFCDSVLATNV--TQQECC-------------------------CSLGAGWG-------- 951
              CD  L   +  ++++C                          CS   G+         
Sbjct: 1181 FQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGC 1240

Query: 952  ---DHCEI---------------YPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRD 993
               D C I               Y C   S +E ++L PDG+                 D
Sbjct: 1241 TDIDECMIMNGGCDTQCTNSEGSYEC---SCSEGYALMPDGRSCA--------------D 1283

Query: 994  IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCE 1052
            IDEC     +IC  G+C N    Y C C  GF    ++  C+DV+EC L+ + C  G CE
Sbjct: 1284 IDECE-NNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECE 1342

Query: 1053 NTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTF 1112
            NT+G + C C            C   +E E      D+  S     G             
Sbjct: 1343 NTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSF----------- 1391

Query: 1113 DDCCCRQG-RGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1171
              C CR+G  G G +C        G+H  +  ++  +   +      +    +  +  D 
Sbjct: 1392 -KCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDV 1450

Query: 1172 DECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1226
            DEC      C +G+C+  PG   CEC  GF   +    C DIDEC   N    +C    C
Sbjct: 1451 DECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQN----ICVFGTC 1506

Query: 1227 VNTSGSFRCVCKAGFARSRPHGAC 1250
             N  G F C+C  G+   R  G C
Sbjct: 1507 NNLPGMFHCICDDGYELDRTGGNC 1530



 Score =  249 bits (636), Expect = 1e-65
 Identities = 184/581 (31%), Positives = 230/581 (39%), Gaps = 135/581 (23%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631
            +TDEC +  N CG+G C      + C+CN G+   P    C D+NEC   P  C      
Sbjct: 2213 DTDECSIG-NPCGNGTCTNVIGSFECNCNEGFEPGPMMN-CEDINECAQNPLLCAFR--- 2267

Query: 632  CMNTGGSYNCHCNRGYRLH-----------------------------VGA--------- 653
            CMNT GSY C C  GY L                              +G          
Sbjct: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGM 2327

Query: 654  ----GGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPP--------- 699
                 G  CVD NEC  KP +C + G C+N  G Y+C C  G++  +S            
Sbjct: 2328 ARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386

Query: 700  -------VCEDIDECRD----PSSCPDG------KCENKP----GSFKCIACQ-PGYRSQ 737
                   +C+     R+       C DG      +CE  P      +K I    PGY + 
Sbjct: 2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTD 2446

Query: 738  GGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
            G    RD++EC    + C+ G C N  GSFRC C  GY     G SC+D+DEC       
Sbjct: 2447 G----RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC 2502

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGH 856
            N IC NT GS+QC C  GY L  D   C+D+DEC          C+NT G + C CP G 
Sbjct: 2503 NYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF 2562

Query: 857  RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHK 916
                   C D +EC   PSLC   G C+N  GS+ C C  GF+       CE+V++    
Sbjct: 2563 TQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGN 2621

Query: 917  KECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKG 976
              C                   Q  C   LG         Y C           CP  +G
Sbjct: 2622 HRC-------------------QHGCQNILGG--------YRCG----------CP--QG 2642

Query: 977  YTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVD 1036
            Y Q     +Y      D +EC       C    C NT   Y+C C  GF +D     C D
Sbjct: 2643 YIQ-----HYQWNQCVDENECS--NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHD 2695

Query: 1037 VDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
            V+EC    N  N  C NT GGY C C PP  Y   Q  C+S
Sbjct: 2696 VNECSSSKNPCNYGCSNTEGGYLCGC-PPGYYRVGQGHCVS 2735



 Score =  236 bits (602), Expect = 1e-61
 Identities = 174/591 (29%), Positives = 245/591 (41%), Gaps = 57/591 (9%)

Query: 295  PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP----------------VRGEVG 338
            PG+     C  + G+   + +C     L YTGV+                    V G   
Sbjct: 2179 PGICSNGQCINTDGSF--RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFE 2236

Query: 339  ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
             +C +G++     +C+DINECA   +     C+N  GSY C CP G++L   +  C  D 
Sbjct: 2237 CNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC-KDL 2295

Query: 399  PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE-ICPA 457
             E         S    C++ + T +    C C  G A     + C  +     K  IC  
Sbjct: 2296 DECAEGLHDCESRGMMCKNLIGTFM----CICPPGMARRPDGEGCVDENECRTKPGICEN 2351

Query: 458  GKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSP 517
            G+  +I+ S++    +G    S     +     Q L  +       +     R + T S 
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSS--GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSE 2409

Query: 518  VSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDE 577
               +      H            EL   P     +   P  P          T   + DE
Sbjct: 2410 CCCDGGRGWGHQC----------ELCPLPGTAQYKKICPHGPGYT-------TDGRDIDE 2452

Query: 578  CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
            C++  N+C +G+C+     + C C  GY +      C+D++EC   P  P   IC NT G
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP-KPCNYICKNTEG 2511

Query: 638  SYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
            SY C C RGY L     G++C DL+EC  K H C     C+N  G + C C PG+     
Sbjct: 2512 SYQCSCPRGYVLQ--EDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGF---TQ 2564

Query: 697  RPPVCEDIDEC-RDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP 753
                C D +EC   PS C   G C+N PGSF C  CQ G+     G  C DV+EC     
Sbjct: 2565 HHTACIDNNECGSQPSLCGAKGICQNTPGSFSC-ECQRGFSLDATGLNCEDVDECDGNHR 2623

Query: 754  CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
            C  G C+N+ G +RC C QGY        C+D +EC   + C +  C NT GS++C C S
Sbjct: 2624 CQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682

Query: 814  GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC 864
            G+   +  S C D++EC          C NT G Y C CP G+  VG   C
Sbjct: 2683 GFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHC 2733



 Score =  230 bits (586), Expect = 7e-60
 Identities = 206/737 (27%), Positives = 280/737 (37%), Gaps = 153/737 (20%)

Query: 582  QNICGHGECVPGPPDYSC-------HCNPGYRSHPQHRYCVDVNECEAEPCGP--GRGIC 632
            +N C +G    GP   +C        C   YR+ P     V+   C+ +  G    + +C
Sbjct: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQ-VNNQMCQGQLTGIVCTKTLC 239

Query: 633  MNTGGSYNCH-----------CNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFP 680
              T G    H           C RG+  ++  G  +C D++EC A P +C  GG CIN  
Sbjct: 240  CATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG--ACQDVDECQAIPGIC-QGGNCINTV 296

Query: 681  GHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGY-RSQG 738
            G ++C C  G++ ++     CEDIDEC   P  C  G+C N  GS+ C+ C  GY  S  
Sbjct: 297  GSFECRCPAGHK-QSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV-CPRGYVTSTD 354

Query: 739  GGACRD----------VN-ECAEGSP---------CSPGWC------------------- 759
            G  C D          VN  CA+  P         C PG C                   
Sbjct: 355  GSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYR 414

Query: 760  ---------ENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGS 806
                       +PGS       T   G+AP+ +G                NG      G+
Sbjct: 415  RLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGA 474

Query: 807  FQCQCLSGYHLSRDRSHCEDIDECDFPA-ACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865
                   G  ++      + ID C   A  C+ G CI T  SYRC C  G++      C 
Sbjct: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCI 534

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDD 925
            D+DEC+ +P     +G C N  GSY C C  GF  T  +  C +++      EC  N   
Sbjct: 535  DVDECTSNP---CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDID------ECIQN--- 582

Query: 926  TVFCDSVLATNVTQQ-ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIV 984
             V C +    N     +C C+ G                      L  DGK         
Sbjct: 583  GVLCKNGRCVNTDGSFQCICNAG--------------------FELTTDGKNCV------ 616

Query: 985  NYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044
                    D DEC    + +C  G C+N    ++C CK GF    N   C DVDEC    
Sbjct: 617  --------DHDECTT--TNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPG 666

Query: 1045 NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGP 1104
             C NG C N+ G +RC C P        R C+           R  C+    + G+C  P
Sbjct: 667  ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD-------THMRSTCYGGI-KKGVCVRP 718

Query: 1105 LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDE 1164
              G     + CC     G+G  C+PCP +            S  F       +G      
Sbjct: 719  FPGAVTKSECCCANPDYGFGEPCQPCPAK-----------NSAEFHGLCSSGVGITVDGR 767

Query: 1165 DSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224
            D +E   D   C +G C    G   C C  G++ DAS   C+DIDEC  +N+  LLC + 
Sbjct: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL-VNR--LLCDNG 824

Query: 1225 RCVNTSGSFRCVCKAGF 1241
             C NT GS+ C C  G+
Sbjct: 825  LCRNTPGSYSCTCPPGY 841



 Score =  196 bits (499), Expect = 9e-50
 Identities = 205/810 (25%), Positives = 287/810 (35%), Gaps = 217/810 (26%)

Query: 532  TTTPARPYPELISRPSPPTMR-----------WFLPDLPPSRSAVEIAPTQVTETDECRL 580
            T    +P P    RP PP  +           +  P+     +AV     +  + D  R 
Sbjct: 26   TAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLR- 84

Query: 581  NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640
              N+CG          +  +C PG+++ P    C+ V  C    CG G   C        
Sbjct: 85   GPNVCGSR--------FHSYCCPGWKTLPGGNQCI-VPICR-NSCGDG--FCSRPN---M 129

Query: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
            C C+ G ++    G +S   + +C+    C +GG C +      C C  GY       PV
Sbjct: 130  CTCSSG-QISSTCGSKS---IQQCSVR--CMNGGTCADD----HCQCQKGYIGTYCGQPV 179

Query: 701  CEDIDE----CRDPSSCP------DGKCENKPGSFKCIACQPGYRSQG---GGACRDVNE 747
            CE+  +    C  P+ C         +CE    +  C         QG   G  C     
Sbjct: 180  CENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLC 239

Query: 748  CAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGS 806
            CA         CE  P   +  C +G+ P     +C DVDEC+A   +C  G C NT GS
Sbjct: 240  CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS 298

Query: 807  FQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGH-RLVGGRKC 864
            F+C+C +G+  S     CEDIDEC   P  C  G+C NT GSY C+CP+G+     G +C
Sbjct: 299  FECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358

Query: 865  QDIDECSQDPSLC---LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921
             D     Q   +C   L +G C                        +E+     K +C  
Sbjct: 359  ID-----QRTGMCFSGLVNGRC-----------------------AQELPGRMTKMQC-- 388

Query: 922  NFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD-------- 973
                                 CC  G  WG       CPV  S E+  LC D        
Sbjct: 389  ---------------------CCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIP 427

Query: 974  -----------GKGYTQDNNIVNYG--------IPA------------------------ 990
                       G G+    N   YG        IP                         
Sbjct: 428  GSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITG 487

Query: 991  ----HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
                ++ ID C    + +C  G+C+ T   Y C C  G+  D N  +C+DVDEC   + C
Sbjct: 488  LTILNQTIDICK-HHANLCLNGRCIPTVSSYRCECNMGYKQDAN-GDCIDVDEC-TSNPC 544

Query: 1047 RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLA 1106
             NG C NT G Y C C    + +P ++ C+   +++   +   +C     ++G C     
Sbjct: 545  TNGDCVNTPGSYYCKCHAGFQRTPTKQACI---DIDECIQNGVLC-----KNGRCVNTDG 596

Query: 1107 GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDS 1166
                    C C                 AG    T                GK   D D 
Sbjct: 597  S-----FQCIC----------------NAGFELTTD---------------GKNCVDHD- 619

Query: 1167 SEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1226
              E +    C++G C+   G   C C  GF L  +   C D+DEC    Q   +C +  C
Sbjct: 620  --ECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC----QTPGICMNGHC 673

Query: 1227 VNTSGSFRCVCKAGFARSRPHGACVPQRRR 1256
            +N+ GSFRC C  G A       CV    R
Sbjct: 674  INSEGSFRCDCPPGLAVGMDGRVCVDTHMR 703



 Score =  130 bits (328), Expect = 6e-30
 Identities = 60/167 (35%), Positives = 90/167 (53%), Gaps = 22/167 (13%)

Query: 296  GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQD 355
            G T + +CC ++G AWG S C +C                E+   CP+G  R+    C+D
Sbjct: 913  GATLKSECCATLGAAWG-SPCERC----------------ELDTACPRGLARIKGVTCED 955

Query: 356  INECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414
            +NEC + PGVC +G C+N+ GS+ C CP G +L  +   C+  + E+   C+ L   E +
Sbjct: 956  VNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ---CY-LKWDEDE 1011

Query: 415  CQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461
            C HP+  +     CCC+VG AWG  C+ CP  GT  ++ +CP G G+
Sbjct: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 38/188 (20%)

Query: 303 CCGSIGTAWGQSKCHKCPQLQYT------------------------GVQKPGPVRGEVG 338
           CC +IG AWG   C  CP                             G+ + G     VG
Sbjct: 239 CCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVG 297

Query: 339 A---DCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
           +    CP G+K+  +T  C+DI+EC++ PG+C  G+C N  GSY CVCP G+      ++
Sbjct: 298 SFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSR 357

Query: 394 CIADKPEEKSLCFR-LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAA 450
           CI    +   +CF  LV+   +C   L  R+T+  CCC  G+ WG     + CP  G+  
Sbjct: 358 CI---DQRTGMCFSGLVN--GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEE 412

Query: 451 FKEICPAG 458
           ++ +C  G
Sbjct: 413 YRRLCMDG 420



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 13/138 (9%)

Query: 349 NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRL 408
           N  +C D++EC  PG+C +G C+N+ GS+RC CPPG ++G     C+      +S C+  
Sbjct: 652 NGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--DTHMRSTCYGG 709

Query: 409 VSPEHQCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSH 467
           +  +  C  P    +T+  CCC +    +G  CQ CP   +A F  +C +G G       
Sbjct: 710 IK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG------- 761

Query: 468 QTLTIQGESDFSLFLHPD 485
             +T+ G       L PD
Sbjct: 762 --ITVDGRDINECALDPD 777



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 48/160 (30%), Positives = 70/160 (43%), Gaps = 40/160 (25%)

Query: 341  CPQGYKRL-NSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
            C +GY+   +  +C D NEC A+PG C  G C N  GS+RC+CPPG+ +       I + 
Sbjct: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINEC 2060

Query: 399  PEEKSLC-----------FRLVSP-------------------------EHQCQHPLTTR 422
             E+ ++C           F+ + P                           +C  P    
Sbjct: 2061 DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFN 2120

Query: 423  LTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKG 460
             T+  CCCS   G+ WG  C+ CP D   AF+++CP G G
Sbjct: 2121 TTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 12/125 (9%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
           G     CP GY  R  +  C+DINEC     C +G C NN GS+ C C PG  L  +   
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLI 889

Query: 394 CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE 453
           CI      K  C+ L   + +C+  +     +  CC ++G AWG+ C+RC  D       
Sbjct: 890 CI---DSLKGTCW-LNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELD------T 939

Query: 454 ICPAG 458
            CP G
Sbjct: 940 ACPRG 944



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGE 336
            G+C ++T+    C  N    L  +E  C  I       +C   P L  +G+    P  G 
Sbjct: 1087 GKC-RNTIGSFKCRCNSGFALDMEERNCTDI------DECRISPDLCGSGICVNTP--GS 1137

Query: 337  VGADCPQGYKR--LNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
               +C +GY+   +   +C DI+EC   P +CR G C+N  GS++C CP GH L PSR  
Sbjct: 1138 FECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRED 1197

Query: 394  CI 395
            C+
Sbjct: 1198 CV 1199



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 25/151 (16%)

Query: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPV 333
            G CF + L      ++    L  + +CC   G  WG  +C  CP     QY  +   GP 
Sbjct: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH-QCELCPLPGTAQYKKICPHGP- 2441

Query: 334  RGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
                      GY    +T  +DI+EC  MP +C +G C+N  GS+RC C  G++   S T
Sbjct: 2442 ----------GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487

Query: 393  QCI-----ADKPEEKSLCFRLVSPEHQCQHP 418
             CI     +  P+  +   +     +QC  P
Sbjct: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCSCP 2518



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 25/129 (19%)

Query: 287  QPCGSNPLPGLTKQEDCCGSI---------GTAWGQSKCHKCPQLQYTGVQKPGPVRGEV 337
            +PC   P PG    +  CG+I         G A    +C + P     G+   G    ++
Sbjct: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIP-----GICANGVCINQI 1828

Query: 338  GA---DCPQGYKRLNSTH-CQDINECAM-PGVC-RHGDCLNNPGSYRCVCPPGHSLGPS- 390
            G+   +CP G+   +    C+DI+EC+    +C R+ DC+N+PGSYRC C  G  L P+ 
Sbjct: 1829 GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG 1888

Query: 391  ----RTQCI 395
                R +C+
Sbjct: 1889 ACVDRNECL 1897



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 46/238 (19%)

Query: 333  VRGEVGADCPQGY-KRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            + G     CPQGY +      C D NEC+ P  C    C N  GSY+C CP G S     
Sbjct: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFS 2690

Query: 392  TQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451
            + C      + + C    S ++ C +  +      LC              CP       
Sbjct: 2691 SAC-----HDVNEC---SSSKNPCNYGCSNTEGGYLC-------------GCPPGYYRVG 2729

Query: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511
            +  C +G G++     Q L++  E D       +    P+   E        +D+ ++R 
Sbjct: 2730 QGHCVSGMGFN---KGQYLSLDTEVD------EENALSPEACYECKINGYSKKDSRQKRS 2780

Query: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569
            +    P + E+   +S               +   SP  M++ L  L      +E+ P
Sbjct: 2781 IHEPDPTAVEQISLES---------------VDMDSPVNMKFNLSHLGSKEHILELRP 2823



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
           P       +C  GYK+  +  C D++EC     C +GDC+N PGSY C C  G    P++
Sbjct: 512 PTVSSYRCECNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTK 570

Query: 392 TQCI 395
             CI
Sbjct: 571 QACI 574



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 327  VQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385
            +  PG  R E    C  G+K   +  C D NEC  +P VC HG C++  GSY+C+C  G 
Sbjct: 1868 INSPGSYRCE----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923

Query: 386  SLGPSRTQCIADKPEEKSLC 405
                 +T C+     E+  C
Sbjct: 1924 KASQDQTMCMDVDECERHPC 1943



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 45/156 (28%), Positives = 66/156 (42%), Gaps = 28/156 (17%)

Query: 293 PLPG-LTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQGYKRL 348
           P PG +TK E CC +    +G+  C  CP     ++ G+   G     VG          
Sbjct: 718 PFPGAVTKSECCCANPDYGFGEP-CQPCPAKNSAEFHGLCSSG-----VGI--------- 762

Query: 349 NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
            +   +DINECA+ P +C +G C N  GSYRC C  G+    S   CI     ++ L  R
Sbjct: 763 -TVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI---DIDECLVNR 818

Query: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443
           L+     C++   +      C C  G  +    + C
Sbjct: 819 LLCDNGLCRNTPGS----YSCTCPPGYVFRTETETC 850



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
            G     C  G++  ++  C DI+EC+     VCR+G C N  GS++C+C  G+ L P   
Sbjct: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012

Query: 393  QCI 395
             CI
Sbjct: 2013 NCI 2015



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 13/90 (14%)

Query: 359 CAMPGVCRHGDCLNNP---GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQC 415
           C  P VC +G C N     G  RC C  G + GP   QC  ++      CF  V+ +  C
Sbjct: 175 CGQP-VCENG-CQNGGRCIGPNRCACVYGFT-GP---QC--ERDYRTGPCFTQVNNQ-MC 225

Query: 416 QHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444
           Q  LT  + T+ LCC ++G+AWG  C+ CP
Sbjct: 226 QGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 335 GEVGADCPQGYKRLNSTH-CQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
           G     C  G++R  +   C DI+EC   GV C++G C+N  GS++C+C  G  L     
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613

Query: 393 QCI 395
            C+
Sbjct: 614 NCV 616



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 333  VRGEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
            ++G     C  G+K   + T C D++EC     C +G C N  GSY C+C PG  L
Sbjct: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHP-CGNGTCKNTVGSYNCLCYPGFEL 1965



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 45/164 (27%), Positives = 61/164 (37%), Gaps = 30/164 (18%)

Query: 6   GAAGG-LAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKV 64
           G+ GG LAPE R  GAA               +  RV     G++    G  +   RF  
Sbjct: 53  GSEGGFLAPEYREEGAA---------------VASRVRR--RGQQDVLRGPNVCGSRFHS 95

Query: 65  VFAP----VICKRTCLKGQCRDSCQQG----SNMTLIGENGHSTDTLTGSGFRVVVCPLP 116
              P    +     C+   CR+SC  G     NM        S+   T     +  C + 
Sbjct: 96  YCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS---TCGSKSIQQCSVR 152

Query: 117 CMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160
           CMNGG C+  + C C   + G +C  P    G   GG   G +R
Sbjct: 153 CMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNR 195



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 19/75 (25%)

Query: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126
           C   C+ G  C D    CQ+G   T  G+                VC   C NGG+C   
Sbjct: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQP---------------VCENGCQNGGRCIGP 193

Query: 127 NQCLCPPDFTGRFCQ 141
           N+C C   FTG  C+
Sbjct: 194 NRCACVYGFTGPQCE 208


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  218 bits (554), Expect = 4e-56
 Identities = 167/540 (30%), Positives = 248/540 (45%), Gaps = 91/540 (16%)

Query: 563  SAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA 622
            S+VE    Q+ ET   +++ +I           D S  C  G+       +C D +EC A
Sbjct: 5062 SSVESDYNQIEETLGFKIHASI--------SKGDRSNQCPSGFTLDSVGPFCADEDECAA 5113

Query: 623  -EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFP 680
              PC      C N  G+Y C C +G  L + A GR+C D++ECA   H C  G  C N  
Sbjct: 5114 GNPCSHS---CHNAMGTYYCSCPKG--LTIAADGRTCQDIDECALGRHTCHAGQDCDNTI 5168

Query: 681  GHYKC--NCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG 738
            G Y+C   C  G+R + S    C+DI+EC++ S C   +C N  GSF C  C+PGY+ +G
Sbjct: 5169 GSYRCVVRCGSGFR-RTSDGLSCQDINECQESSPCHQ-RCFNAIGSFHC-GCEPGYQLKG 5225

Query: 739  GGACRDVNECAEGSPCSPGW-CENLPGSFRCT--CAQGYAPAPDGRSCLDVDECEAGD-V 794
               C DVNEC + + C P   C+N  G ++C   C  G   A +G +C+D+DEC+ G   
Sbjct: 5226 R-KCMDVNECRQ-NVCRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQ 5282

Query: 795  CD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
            C  N IC NT GS++C C  GY        C DI+EC+         C NT GS++C+CP
Sbjct: 5283 CRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICP 5342

Query: 854  QGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
             G  L+G G+ C  ++         LP     N    Y       F+P ++ +      Q
Sbjct: 5343 PGQHLLGDGKSCAGLER--------LP-----NYGTQYSSYNLARFSPVRNNY----QPQ 5385

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
             H+++  +L    + + +S  + + T++                              CP
Sbjct: 5386 QHYRQYSHLYSSYSEYRNSRTSLSRTRR-------------------------TIRKTCP 5420

Query: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL 1032
            +G   + D  +         DIDEC    ++ C+  +C NT   Y+C C  G+    N  
Sbjct: 5421 EGSEASHDTCV---------DIDECE--NTDACQH-ECKNTFGSYQCICPPGYQLTHNGK 5468

Query: 1033 ECVDVDECLDES-NC-RNGVCENTRGGYRC---ACTPPAEYSPAQRQCLS---PEEMERA 1084
             C D+DECL+++ +C  N +C N RG Y+C    C P  +  P    CL    P ++E A
Sbjct: 5469 TCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECA 5528



 Score =  149 bits (376), Expect = 2e-35
 Identities = 141/492 (28%), Positives = 186/492 (37%), Gaps = 97/492 (19%)

Query: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG 860
            S + G    QC SG+ L      C D DEC     C    C N  G+Y C CP+G  +  
Sbjct: 5082 SISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNPC-SHSCHNAMGTYYCSCPKGLTIAA 5140

Query: 861  -GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV--CDEGFTPTQDQHGCEEVEQPHHKK 917
             GR CQDIDEC+     C     C N  GSY CV  C  GF  T D   C+++ +     
Sbjct: 5141 DGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESS 5200

Query: 918  ECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGY 977
             C+                   Q C  ++G+                  FH  C  G   
Sbjct: 5201 PCH-------------------QRCFNAIGS------------------FHCGCEPG--- 5220

Query: 978  TQDNNIVNYGIPAHR--DIDECMLFGSEICKEGK-CVNTQPGYECY--CKQGFYYDGNLL 1032
                    Y +   +  D++EC      +C+  + C NT+ GY+C   C  G     N  
Sbjct: 5221 --------YQLKGRKCMDVNECR---QNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT 5269

Query: 1033 ECVDVDECLDESN-CR-NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDV 1090
             C+D+DEC D ++ CR N +CENTRG YRC C          R C+   E E+ P+    
Sbjct: 5270 -CIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAH 5328

Query: 1091 CWSQRGEDGMCAGPLAGPALTFDDCCCRQGR--GWGAQ------CRPCPPRG-------- 1134
              S       C  P     L     C    R   +G Q       R  P R         
Sbjct: 5329 QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHY 5388

Query: 1135 -AGSHCPTSQSE----SNSFWDTSPLLLGKPPRDEDSSEE---DSDECR---CVSGRCVP 1183
               SH  +S SE      S   T   +    P   ++S +   D DEC         C  
Sbjct: 5389 RQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKN 5448

Query: 1184 RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSER-CVNTSGSFRCV---CKA 1239
              G   C CP G+QL  +   C DIDEC E N   + C   R C N  GS++C+   C  
Sbjct: 5449 TFGSYQCICPPGYQLTHNGKTCQDIDECLEQN---VHCGPNRMCFNMRGSYQCIDTPCPP 5505

Query: 1240 GFARSRPHGACV 1251
             + R    G C+
Sbjct: 5506 NYQRDPVSGFCL 5517



 Score =  148 bits (373), Expect = 4e-35
 Identities = 118/358 (32%), Positives = 154/358 (43%), Gaps = 71/358 (19%)

Query: 587  HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCH--CN 644
            H  C      + C C PGY+   + R C+DVNEC    C P +  C NT G Y C   C 
Sbjct: 5203 HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQH-CKNTRGGYKCIDLCP 5259

Query: 645  RGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCED 703
             G      A   +C+D++EC    H C     C N  G Y+C C  GYR +    P C D
Sbjct: 5260 NGM---TKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRP-CMD 5315

Query: 704  IDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNEC------------A 749
            I+EC   P  C   +C N PGSFKCI C PG    G G +C  +               A
Sbjct: 5316 INECEQVPKPCAH-QCSNTPGSFKCI-CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLA 5373

Query: 750  EGSPCSPGW--------CENLPGSF-----------------RCTCAQGYAPAPDGRSCL 784
              SP    +          +L  S+                 R TC +G   + D  +C+
Sbjct: 5374 RFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCV 5431

Query: 785  DVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD--CI 842
            D+DECE  D C +  C NT GS+QC C  GY L+ +   C+DIDEC       G +  C 
Sbjct: 5432 DIDECENTDACQHE-CKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCF 5490

Query: 843  NTNGSYRCL---CPQGHRL--VGG---RKCQDID-ECSQDP------SLCLPHGACKN 885
            N  GSY+C+   CP  ++   V G   + C   D EC+  P       + LP G   N
Sbjct: 5491 NMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATN 5548



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 90/340 (26%), Positives = 133/340 (39%), Gaps = 57/340 (16%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
            C  G++R +    CQDINEC     C H  C N  GS+ C C PG+ L     +C+    
Sbjct: 5177 CGSGFRRTSDGLSCQDINECQESSPC-HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNE 5233

Query: 400  EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC---QRCPTDGT--AAFKEI 454
              +++C     P+  C++         LC   + KA    C     C  DGT    + +I
Sbjct: 5234 CRQNVC----RPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDEC-KDGTHQCRYNQI 5288

Query: 455  CPAGKGYHILTSHQTLTIQGESDFSLFLHP-DGPPKP--QQLPESPSQ----APPPE--- 504
            C   +G +     +    QG     + ++  +  PKP   Q   +P       PP +   
Sbjct: 5289 CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLL 5348

Query: 505  -DTEEERG---------------VTTDSPVSEERSVQQ-----SHPTATTTPARPYPELI 543
             D +   G               +   SPV      QQ     SH  ++ +  R     +
Sbjct: 5349 GDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSL 5408

Query: 544  SRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNP 603
            SR +  T+R   P+        E +     + DEC  N + C H EC      Y C C P
Sbjct: 5409 SR-TRRTIRKTCPE------GSEASHDTCVDIDECE-NTDACQH-ECKNTFGSYQCICPP 5459

Query: 604  GYRSHPQHRYCVDVNEC--EAEPCGPGRGICMNTGGSYNC 641
            GY+     + C D++EC  +   CGP R +C N  GSY C
Sbjct: 5460 GYQLTHNGKTCQDIDECLEQNVHCGPNR-MCFNMRGSYQC 5498



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 18/104 (17%)

Query: 296  GLTKQEDCCGSIGTAWGQSKC----HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-S 350
            G+TK E+     GT     +C    H+C   +Y  + +    RG     CP+GY+     
Sbjct: 5261 GMTKAEN-----GTCIDIDECKDGTHQC---RYNQICEN--TRGSYRCVCPRGYRSQGVG 5310

Query: 351  THCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPG-HSLGPSRT 392
              C DINEC  +P  C H  C N PGS++C+CPPG H LG  ++
Sbjct: 5311 RPCMDINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKS 5353



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 2/61 (3%)

Query: 334  RGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393
            R  +   CP+G +  + T C DI+EC     C+H +C N  GSY+C+CPPG+ L  +   
Sbjct: 5412 RRTIRKTCPEGSEASHDT-CVDIDECENTDACQH-ECKNTFGSYQCICPPGYQLTHNGKT 5469

Query: 394  C 394
            C
Sbjct: 5470 C 5470



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 26/71 (36%), Positives = 33/71 (46%), Gaps = 6/71 (8%)

Query: 341  CPQGYKRL-NSTHCQDINECAMPGV-CRHGD-CLNNPGSYRCV---CPPGHSLGPSRTQC 394
            CP GY+   N   CQDI+EC    V C     C N  GSY+C+   CPP +   P    C
Sbjct: 5457 CPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFC 5516

Query: 395  IADKPEEKSLC 405
            + + P     C
Sbjct: 5517 LKNCPPNDLEC 5527



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 22/63 (34%), Positives = 30/63 (47%), Gaps = 4/63 (6%)

Query: 334  RGEVGADCPQGYKRLNST--HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
            +G+    CP G+  L+S    C D +ECA    C H  C N  G+Y C CP G ++    
Sbjct: 5085 KGDRSNQCPSGFT-LDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADG 5142

Query: 392  TQC 394
              C
Sbjct: 5143 RTC 5145


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  210 bits (534), Expect = 8e-54
 Identities = 207/705 (29%), Positives = 289/705 (40%), Gaps = 149/705 (21%)

Query: 577  ECRLNQNICGHG-ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            EC  + ++C HG  CVPG     CHC PG++  P+ +Y  DV+EC     G  +  C+NT
Sbjct: 127  EC--SASLCFHGGRCVPGSAQ-PCHCPPGFQG-PRCQY--DVDECRTHN-GGCQHRCVNT 179

Query: 636  GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFP-GHYKCNCYPGY 691
             GSY C C  G+RLH  +  R+C+ +N CA     G+GG    C+      ++C C PG+
Sbjct: 180  PGSYLCECKPGFRLHTDS--RTCLAINSCA----LGNGGCQHHCVQLTITRHRCQCRPGF 233

Query: 692  RLKASRPPVCEDIDEC--RDPSSCPDGKCENK----PGSFKCIACQPGYR-SQGGGACRD 744
            +L+       ED   C  R P +  +G C ++     G  +C  C  GY+ +  G AC D
Sbjct: 234  QLQ-------EDGRHCVRRSPCANRNGSCMHRCQVVRGLARC-ECHVGYQLAADGKACED 285

Query: 745  VNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-----VDECEAGD-VCDN 797
            V+ECA G + C+ G C N  GSF+C C  GY    DGR C       V+ CEA +  C +
Sbjct: 286  VDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH 344

Query: 798  GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGH 856
            G CS+T     C C  GY L  D+  C D+D+C D P  C    C N  G Y C C  G+
Sbjct: 345  G-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGGYECGCYAGY 401

Query: 857  RL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            RL   G  C+D+DEC+     C  H  C NL GS+ C C+ G+   +D+ GC  +E+P  
Sbjct: 402  RLSADGCGCEDVDECASSRGGCEHH--CTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMV 459

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              +  L F   +   +VL   + Q      +GA   D  E      ++  E      D  
Sbjct: 460  DLDGELPFVRPLPHIAVLQDELPQLFQDDDVGA---DEEEAELRGEHTLTEKFVCLDDSF 516

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECV 1035
            G+                  +C L   +    G C+    G  C C +G+      L C 
Sbjct: 517  GH------------------DCSLTCDDCRNGGTCLLGLDG--CDCPEGW----TGLICN 552

Query: 1036 DV-------DECLDESNCRN-GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPER 1087
            +          C    +C+N G C++  G   C C P    +  +  C  P+       R
Sbjct: 553  ETCPPDTFGKNCSFSCSCQNGGTCDSVTGA--CRCPPGVSGTNCEDGC--PKGYYGKHCR 608

Query: 1088 RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCR-PCPPRGAGSHCPTSQSES 1146
            +    + RG      G           C C  G  +G  C   CPP   G  C       
Sbjct: 609  KKCNCANRGRCHRLYGA----------CLCDPGL-YGRFCHLTCPPWAFGPGC------- 650

Query: 1147 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCV---SGRCVPRPGGAVCECPGGFQLDASRA 1203
                                    S+EC+CV   +  C  R G   C C  GF+ +  +A
Sbjct: 651  ------------------------SEECQCVQPHTQSCDKRDGS--CSCKAGFRGERCQA 684

Query: 1204 RCVDIDECRELNQRGLLC-------KSERCVNTSGSFRCVCKAGF 1241
             C       EL   G  C           C + SG     C AGF
Sbjct: 685  EC-------ELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGF 722



 Score =  195 bits (496), Expect = 2e-49
 Identities = 202/724 (27%), Positives = 277/724 (38%), Gaps = 114/724 (15%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
            + DECR +   C H  CV  P  Y C C PG+R H   R C+ +N C     G       
Sbjct: 161  DVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN----FPGHYKCNCYP 689
             T   + C C  G++L     GR CV  + CA  +     G C++      G  +C C+ 
Sbjct: 220  LTITRHRCQCRPGFQLQ--EDGRHCVRRSPCANRN-----GSCMHRCQVVRGLARCECHV 272

Query: 690  GYRLKASRPPVCEDIDECRDP-SSCPDGKCENKPGSFKCIACQPGYRSQGGGA------C 742
            GY+L A     CED+DEC    + C  G C N  GSFKC+ C  GY     G        
Sbjct: 273  GYQLAADGK-ACEDVDECAAGLAQCAHG-CLNTQGSFKCV-CHAGYELGADGRQCYRIEM 329

Query: 743  RDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICS 801
              VN C A    CS G C +      CTC +GY    D R+C+DVD+C A   C   +C+
Sbjct: 330  EIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDC-ADSPCCQQVCT 387

Query: 802  NTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGG 861
            N PG ++C C +GY LS D   CED+DEC          C N  GS++C C  G+RL   
Sbjct: 388  NNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHED 447

Query: 862  RK-CQDIDECSQDPS------LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPH 914
            R+ C  ++E   D          LPH A   LQ     +  +      ++    E+   H
Sbjct: 448  RRGCSPLEEPMVDLDGELPFVRPLPHIAV--LQDELPQLFQDDDVGADEEEA--ELRGEH 503

Query: 915  HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPV-YSSAEFHSLCPD 973
               E ++  DD+   D  L  +  +    C LG    D C+   CP  ++    +  CP 
Sbjct: 504  TLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGL---DGCD---CPEGWTGLICNETCPP 557

Query: 974  ---GKGYTQDNNIVNYGIPAHRDIDEC-MLFGSEICKEG-KCVNTQPGYECYCKQGFYYD 1028
               GK  +   +  N G         C  + G+  C  G    N + G    C +G+Y  
Sbjct: 558  DTFGKNCSFSCSCQNGG--------TCDSVTGACRCPPGVSGTNCEDG----CPKGYYGK 605

Query: 1029 GNLLECVDVDECLDESNCRN--GVCENTRGGYRCAC---TPPAEYSPA---QRQCLSPEE 1080
                +C     C +   C    G C    G Y   C    PP  + P    + QC+ P  
Sbjct: 606  HCRKKC----NCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQP-H 660

Query: 1081 MERAPERRDVCWSQRGEDG-----MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA 1135
             +   +R   C  + G  G      C     GP   +  C C  G    +    C     
Sbjct: 661  TQSCDKRDGSCSCKAGFRGERCQAECELGYFGPG-CWQACTCPVGVACDSVSGEC----- 714

Query: 1136 GSHCPTS-QSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPG 1194
            G  CP   Q E            G+           S  C C    C    G   C CP 
Sbjct: 715  GKRCPAGFQGED----------CGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPP 762

Query: 1195 GFQLDASRARCVDIDECRELNQRGLLCK--------SERCVNTSGSFRCVCKAGFARSRP 1246
            G   +   A C +        + GL C+        + RC   +G+  C+C  GF  SR 
Sbjct: 763  GRTGEDCEADCPE-------GRWGLGCQEICPACQHAARCDPETGA--CLCLPGFVGSRC 813

Query: 1247 HGAC 1250
               C
Sbjct: 814  QDVC 817



 Score =  107 bits (267), Expect = 7e-23
 Identities = 146/633 (23%), Positives = 201/633 (31%), Gaps = 208/633 (32%)

Query: 770  CAQGYAPAPDGRSCL------------------------------------DVDECEAGD 793
            C +G+   PD   CL                                    DVDEC   +
Sbjct: 110  CCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHN 169

Query: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF--------------------- 832
                  C NTPGS+ C+C  G+ L  D   C  I+ C                       
Sbjct: 170  GGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQC 229

Query: 833  -----------------PAACIGGDCIN----TNGSYRCLCPQGHRLVG-GRKCQDIDEC 870
                             P A   G C++      G  RC C  G++L   G+ C+D+DEC
Sbjct: 230  RPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDEC 289

Query: 871  SQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCD 930
            +   + C  HG C N QGS+ CVC  G+    D   C  +E                  +
Sbjct: 290  AAGLAQC-AHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEME--------------IVN 333

Query: 931  SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990
            S  A N      C    AG                    LC   +GY  D +        
Sbjct: 334  SCEANNGGCSHGCSHTSAG-------------------PLCTCPRGYELDTD-----QRT 369

Query: 991  HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050
              D+D+C       C +  C N   GYEC C  G+    +   C DVDEC          
Sbjct: 370  CIDVDDC---ADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHH 426

Query: 1051 CENTRGGYRCACTPPAEYSPAQRQC------------------------LSPEEMERAPE 1086
            C N  G ++C+C         +R C                        +  +E+ +  +
Sbjct: 427  CTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQ 486

Query: 1087 RRDVCWSQ-----RGEDGM-----CAGPLAGP--ALTFDDC-----C------CRQGRGW 1123
              DV   +     RGE  +     C     G   +LT DDC     C      C    GW
Sbjct: 487  DDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGW 546

Query: 1124 -GAQC-RPCPPRGAGSHCPTSQS-ESNSFWDTSPLLLGKPPRDEDSSEEDS--------- 1171
             G  C   CPP   G +C  S S ++    D+       PP    ++ ED          
Sbjct: 547  TGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKH 606

Query: 1172 --DECRCVS-GRCVPRPGGAVCE-----------CPGGFQLDASRARCVDIDECRELNQR 1217
               +C C + GRC    G  +C+           CP      A    C +  +C + +  
Sbjct: 607  CRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPW----AFGPGCSEECQCVQPH-- 660

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
                 ++ C    GS  C CKAGF   R    C
Sbjct: 661  -----TQSCDKRDGS--CSCKAGFRGERCQAEC 686



 Score =  105 bits (261), Expect = 4e-22
 Identities = 113/449 (25%), Positives = 146/449 (32%), Gaps = 110/449 (24%)

Query: 810  QCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DID 868
            +C  G+    D   C    EC       GG C+    +  C CP G +   G +CQ D+D
Sbjct: 109  RCCRGWMQQPDEEGCLSA-ECSASLCFHGGRCV-PGSAQPCHCPPGFQ---GPRCQYDVD 163

Query: 869  ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928
            EC      C     C N  GSY+C C  GF    D   C                     
Sbjct: 164  ECRTHNGGC--QHRCVNTPGSYLCECKPGFRLHTDSRTC--------------------- 200

Query: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988
                LA N       C+LG G   H     C   +       C  G    +D        
Sbjct: 201  ----LAIN------SCALGNGGCQH----HCVQLTITRHRCQCRPGFQLQEDGRHCVRRS 246

Query: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDE-SNCR 1047
            P       CM          +C   +    C C  G+    +   C DVDEC    + C 
Sbjct: 247  PCANRNGSCM---------HRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCA 297

Query: 1048 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGM-CAGPLA 1106
            +G C NT+G ++C C    E     RQC   E      E  + C +  G     C+   A
Sbjct: 298  HG-CLNTQGSFKCVCHAGYELGADGRQCYRIEM-----EIVNSCEANNGGCSHGCSHTSA 351

Query: 1107 GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDS 1166
            GP      C C +G       R C                                    
Sbjct: 352  GPL-----CTCPRGYELDTDQRTCI----------------------------------- 371

Query: 1167 SEEDSDECR---CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKS 1223
               D D+C    C    C   PGG  C C  G++L A    C D+DEC   + RG     
Sbjct: 372  ---DVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECA--SSRGGC--E 424

Query: 1224 ERCVNTSGSFRCVCKAGFARSRPHGACVP 1252
              C N +GSF+C C+AG+        C P
Sbjct: 425  HHCTNLAGSFQCSCEAGYRLHEDRRGCSP 453



 Score =  101 bits (251), Expect = 5e-21
 Identities = 185/726 (25%), Positives = 228/726 (31%), Gaps = 204/726 (28%)

Query: 586  GHGECVPGPPDYSCH--CNPGYR----SHPQHRYCVDVNECEAEPCGPGRGICMNTGGSY 639
            GH  C PG   +SC   C+ G+     SHP +             C  G G C    G  
Sbjct: 843  GHCSCAPGWTGFSCQRACDTGHWGPDCSHPCN-------------CSAGHGSCDAISGL- 888

Query: 640  NCHCNRGY----------RLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
             C C  GY          + H G G         C +   C  G  C +  G   C C  
Sbjct: 889  -CLCEAGYVGPRCEQQCPQGHFGPG---------CEQRCQCQHGAACDHVSG--ACTCPA 936

Query: 690  GYR---LKASRPPVCEDIDECRDPSSCPDGK-CENKPGSFKCIACQPGYRSQG------- 738
            G+R    + + P     +D CR   +C  G  C+   GS  C A + G R          
Sbjct: 937  GWRGTFCEHACPAGFFGLD-CRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTY 995

Query: 739  GGACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCD 796
            G  C     C  G+ C P  G C   PG    +C Q       G +C     C+ G  CD
Sbjct: 996  GHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCD 1055

Query: 797  NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDE---CDFPAACI-GGDCINTNGSYRCLC 852
                   P S  C C  G+        C   D    C     C+ GG C    G  RCLC
Sbjct: 1056 -------PVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLC 1106

Query: 853  PQGHRLVGGRKCQDI-------DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQH 905
            P G     G KCQ         + C+Q  S C P  AC ++ G+  C C  GFT +    
Sbjct: 1107 PAGWT---GDKCQSPCLRGWFGEACAQRCS-CPPGAACHHVTGA--CRCPPGFTGS---- 1156

Query: 906  GCEEVEQPHHKKECYLNFDDTVFCDSV---LATNVTQQECCCSLGAGWGDHCEIYPCPVY 962
            GCE+   P    E     D    C       A +     C C+ G              Y
Sbjct: 1157 GCEQACPPGSFGE-----DCAQMCQCPGENPACHPATGTCSCAAG--------------Y 1197

Query: 963  SSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCK 1022
                    CP G+          YG P    +  C+  GS     G C          C 
Sbjct: 1198 HGPSCQQRCPPGR----------YG-PGCEQLCGCLNGGSCDAATGAC---------RCP 1237

Query: 1023 QGFYYDGNLLECVDV---DECLDESNCRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSP 1078
             GF      L C        C     C  G  C+   G   C C P       +R C   
Sbjct: 1238 TGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTG--TCLCPPGRAGVRCERGC--- 1292

Query: 1079 EEMERAPERR------DVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGW-GAQCR-PC 1130
                  P+ R        C  + G  G+C         +   C C  G GW G  C   C
Sbjct: 1293 ------PQNRFGVGCEHTCSCRNG--GLCHA-------SNGSCSC--GLGWTGRHCELAC 1335

Query: 1131 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPG--GA 1188
            PP   G+ C    S  N+                         C   +G C   PG  G 
Sbjct: 1336 PPGRYGAACHLECSCHNN-----------------------STCEPATGTCRCGPGFYGQ 1372

Query: 1189 VCE--CPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRP 1246
             CE  CP GF      A C  +  C    Q G  C          S RC+C AGF     
Sbjct: 1373 ACEHPCPPGFH----GAGCQGLCWC----QHGAPCDPI-------SGRCLCPAGFHGHFC 1417

Query: 1247 HGACVP 1252
               C P
Sbjct: 1418 ERGCEP 1423



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 163/679 (24%), Positives = 233/679 (34%), Gaps = 106/679 (15%)

Query: 583  NICGHGECVPGPPDYSCH--CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640
            ++ G   C PG    +C   C  GY      + C   N      C    G C+   G Y 
Sbjct: 578  SVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGR---CHRLYGACLCDPGLYG 634

Query: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700
              C+        A G  C +  +C +PH       C    G   C+C  G+R +  +   
Sbjct: 635  RFCH--LTCPPWAFGPGCSEECQCVQPHTQS----CDKRDG--SCSCKAGFRGERCQAE- 685

Query: 701  CE---DIDECRDPSSCPDG-KCENKPGSFKC-IACQPGYRSQGGGACRDVN----ECAEG 751
            CE       C    +CP G  C++  G  +C   C  G++ +  G    V      C+  
Sbjct: 686  CELGYFGPGCWQACTCPVGVACDSVSG--ECGKRCPAGFQGEDCGQECPVGTFGVNCSSS 743

Query: 752  SPCSPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDE----CEAGDVCDNGICSNT 803
              C    C  + G  RC    T     A  P+GR  L   E    C+    CD       
Sbjct: 744  CSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCD------- 796

Query: 804  PGSFQCQCLSGYHLSRDRSHCEDI-------DECDFPAACIG-GDCINTNGSYRCLCPQG 855
            P +  C CL G+  SR    C+D+         C    +C   G C    G   C C  G
Sbjct: 797  PETGACLCLPGFVGSR----CQDVCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCAPG 850

Query: 856  HRLVGGRKCQDID----ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
                  ++  D      +CS   +    HG+C  + G  +C+C+ G+   + +  C    
Sbjct: 851  WTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQQCP--- 905

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW-GDHCEIYPCPV-YSSAEFHS 969
            Q H    C    +    C    A +     C C   AGW G  CE + CP  +   +  S
Sbjct: 906  QGHFGPGC----EQRCQCQHGAACDHVSGACTCP--AGWRGTFCE-HACPAGFFGLDCRS 958

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECM------LFGSEICKEGKCVN---TQPGY-EC 1019
             C    G   D    +   PA R    C        +G    +   C N     P + +C
Sbjct: 959  ACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQC 1018

Query: 1020 YCKQGFYYDGNLLEC---VDVDECLDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQC 1075
            +C  G+     L  C   +  D C     C+NG  C+   G   CAC         +++C
Sbjct: 1019 HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSG--HCACPEGWAGLACEKEC 1076

Query: 1076 LSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPAL-----TFDDCCCRQGRGW-GAQCRP 1129
            L P ++         C +     G+C  P  G  L     T D C     RGW G  C  
Sbjct: 1077 L-PRDVRAGCRHSGGCLN----GGLC-DPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQ 1130

Query: 1130 ---CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPG 1186
               CPP GA  H  T        +  S      PP      E+ +  C+C        P 
Sbjct: 1131 RCSCPP-GAACHHVTGACRCPPGFTGSGCEQACPPGS--FGEDCAQMCQCPGENPACHPA 1187

Query: 1187 GAVCECPGGFQLDASRARC 1205
               C C  G+   + + RC
Sbjct: 1188 TGTCSCAAGYHGPSCQQRC 1206



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 168/731 (22%), Positives = 224/731 (30%), Gaps = 131/731 (17%)

Query: 596  DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR--------GI-CMNTGGSYNCHCNRG 646
            D SC C  G+R            ECE    GPG         G+ C +  G     C  G
Sbjct: 668  DGSCSCKAGFRGERCQA------ECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAG 721

Query: 647  YR-------LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY---PGYRLKAS 696
            ++         VG  G +C     C      G  G C   PG    +C    P  R    
Sbjct: 722  FQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLG 781

Query: 697  RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG-------GGACRDVNECA 749
               +C        P+     +C+ + G+  C+    G R Q        G +C+    CA
Sbjct: 782  CQEIC--------PACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCA 833

Query: 750  EGSPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCD--NGICSNTP 804
                C P  G C   PG    +C +       G  C     C AG   CD  +G+C    
Sbjct: 834  NDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEA 893

Query: 805  GSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC 864
            G    +C            CE   +C   AAC        + S  C CP G R   G  C
Sbjct: 894  GYVGPRCEQQCPQGHFGPGCEQRCQCQHGAAC-------DHVSGACTCPAGWR---GTFC 943

Query: 865  QDIDECS------QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
            +            +    C    AC  + GS  C+C  G    +    C      H+  +
Sbjct: 944  EHACPAGFFGLDCRSACNCTAGAACDAVNGS--CLCPAGRRGPRCAETCPAHTYGHNCSQ 1001

Query: 919  CYLNFDDTVFCDSV-----LATNVTQQECCCSLGAG-WGDHCEIYPCPVYSSAEF----- 967
                F+    CD V      A       C  +  AG +GD+C  + C   +         
Sbjct: 1002 ACACFNGAS-CDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCR-HSCLCQNGGTCDPVSG 1059

Query: 968  HSLCPDG-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026
            H  CP+G  G   +   +   + A      C   G   C  G   +   G  C C  G+ 
Sbjct: 1060 HCACPEGWAGLACEKECLPRDVRAG-----CRHSGG--CLNGGLCDPHTG-RCLCPAGWT 1111

Query: 1027 YDGNLLECVDV---DECLDESNCRNGV-CENTRGGYRC-----------ACTPPAEYSPA 1071
             D     C+     + C    +C  G  C +  G  RC           AC P +     
Sbjct: 1112 GDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDC 1171

Query: 1072 QRQCLSPEEMERAPERRDVCWSQRGEDG-----MCAGPLAGPALTFDDCCCRQGRGWGAQ 1126
             + C  P E          C    G  G      C     GP      C C  G    A 
Sbjct: 1172 AQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCE-QLCGCLNGGSCDAA 1230

Query: 1127 ---CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP 1183
               CR CP    G+ C            T P     P             C  V+G C+ 
Sbjct: 1231 TGACR-CPTGFLGTDCNL----------TCPQGRFGPNCTHVCGCGQGAACDPVTGTCLC 1279

Query: 1184 RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFAR 1243
             PG A   C  G   +     C     CR     G LC +     ++GS  C C  G+  
Sbjct: 1280 PPGRAGVRCERGCPQNRFGVGCEHTCSCR----NGGLCHA-----SNGS--CSCGLGWTG 1328

Query: 1244 SRPHGACVPQR 1254
                 AC P R
Sbjct: 1329 RHCELACPPGR 1339



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 92/339 (27%), Positives = 112/339 (33%), Gaps = 60/339 (17%)

Query: 594  PPDYSCHCNPGYRSH------PQHRY---CVDVNEC-EAEPCGPGRGICMNTGGSYNCHC 643
            P   +C C  GY         P  RY   C  +  C     C    G C    G     C
Sbjct: 1186 PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC 1245

Query: 644  NRGYRLHVGAGGRSCVDLNECAKPHLCGD-GGFCINFPGHYKCNCYPGYRLKASRPPV-C 701
            N       G  G +C  +  C +   C    G C+  PG     C  G     +R  V C
Sbjct: 1246 N--LTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG--CPQNRFGVGC 1301

Query: 702  EDIDECRDPSSCPDGKCENKPGSFKC----------IACQPGYRSQGGGACRDVNECAEG 751
            E    CR+      G C    GS  C          +AC PG   + G AC     C   
Sbjct: 1302 EHTCSCRN-----GGLCHASNGSCSCGLGWTGRHCELACPPG---RYGAACHLECSCHNN 1353

Query: 752  SPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQC 809
            S C P  G C   PG +   C     P   G  C  +  C+ G  CD       P S +C
Sbjct: 1354 STCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCD-------PISGRC 1406

Query: 810  QCLSGYHLSRDRSHCED---IDECDFPAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQ 865
             C +G+H       CE     + C     C GG  C    G   CLCP G     G  C 
Sbjct: 1407 LCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTG--LCLCPPGR---SGATCN 1461

Query: 866  DIDECSQDPSLCLPH-----GA-CKNLQGSYVCVCDEGF 898
                  Q    C  H     GA C  + G   C C +G+
Sbjct: 1462 LDCRRGQFGPSCTLHCDCGGGADCDPVSGQ--CHCVDGY 1498



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 99/390 (25%), Positives = 129/390 (33%), Gaps = 71/390 (18%)

Query: 585  CGH-GECVPG----PPDYSCHCNPGYRSHPQHRYCVD--VNECEAEPCG-PGRGICMNTG 636
            C H G C+ G    P    C C  G+        C+     E  A+ C  P    C +  
Sbjct: 1085 CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVT 1144

Query: 637  GSYNCHCNRGYR-------LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
            G+  C C  G+           G+ G  C  + +C      G+   C   P    C+C  
Sbjct: 1145 GA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCP-----GENPAC--HPATGTCSCAA 1195

Query: 690  GYRLKASRP--------PVCEDIDECRDPSSCP--DGKCENKPGSFKC---IACQPGYRS 736
            GY   + +         P CE +  C +  SC    G C    G       + C  G   
Sbjct: 1196 GYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQG--- 1252

Query: 737  QGGGACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDV 794
            + G  C  V  C +G+ C P  G C   PG     C +G      G  C     C  G +
Sbjct: 1253 RFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGL 1312

Query: 795  C--DNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAAC--IGGDCINTNGSYRC 850
            C   NG CS   G     C       R  + C     C   + C    G C    G Y  
Sbjct: 1313 CHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQ 1372

Query: 851  LC----PQGHRLVGGRKCQDIDECSQDPSLCLPHGA-CKNLQGSYVCVCDEGFTPTQDQH 905
             C    P G     G  CQ +  C         HGA C  + G   C+C  GF     + 
Sbjct: 1373 ACEHPCPPGFH---GAGCQGLCWCQ--------HGAPCDPISGR--CLCPAGFHGHFCER 1419

Query: 906  GCEE---VEQPHHKKECYLNFDDTVFCDSV 932
            GCE     E  H + +C    D    CD V
Sbjct: 1420 GCEPGSFGEGCHQRCDC----DGGAPCDPV 1445



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 49/161 (30%), Positives = 65/161 (40%), Gaps = 23/161 (14%)

Query: 279 CFQDTLPKQPCGSNPLPGLTKQED---CCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVR 334
           C Q T+ +  C   P  G   QED   C      A     C H+C             VR
Sbjct: 217 CVQLTITRHRCQCRP--GFQLQEDGRHCVRRSPCANRNGSCMHRCQV-----------VR 263

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
           G    +C  GY+   +   C+D++ECA     C HG CLN  GS++CVC  G+ LG    
Sbjct: 264 GLARCECHVGYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGR 322

Query: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           QC   + E  + C    +    C H  +      LC C  G
Sbjct: 323 QCYRIEMEIVNSC---EANNGGCSHGCSHTSAGPLCTCPRG 360



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 29/94 (30%), Positives = 39/94 (41%), Gaps = 10/94 (10%)

Query: 341 CPQGYKR-LNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
           CP+GY+   +   C D+++CA    C+   C NNPG Y C C  G+ L      C     
Sbjct: 357 CPRGYELDTDQRTCIDVDDCADSPCCQQV-CTNNPGGYECGCYAGYRLSADGCGC----- 410

Query: 400 EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
           E+   C    S    C+H  T       C C  G
Sbjct: 411 EDVDEC---ASSRGGCEHHCTNLAGSFQCSCEAG 441



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 32/95 (33%), Positives = 42/95 (44%), Gaps = 13/95 (13%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
           CP G++      CQ D++EC    G C+H  C+N PGSY C C PG  L      C+A  
Sbjct: 149 CPPGFQ---GPRCQYDVDECRTHNGGCQHR-CVNTPGSYLCECKPGFRLHTDSRTCLA-- 202

Query: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
               S        +H C   +   +TR  C C  G
Sbjct: 203 --INSCALGNGGCQHHC---VQLTITRHRCQCRPG 232



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 7/81 (8%)

Query: 316 CHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQDINECAMP-GVCRHGDCLNN 373
           C   P  Q      PG         C  GY+   +   C+D++ECA   G C H  C N 
Sbjct: 376 CADSPCCQQVCTNNPGGYE----CGCYAGYRLSADGCGCEDVDECASSRGGCEH-HCTNL 430

Query: 374 PGSYRCVCPPGHSLGPSRTQC 394
            GS++C C  G+ L   R  C
Sbjct: 431 AGSFQCSCEAGYRLHEDRRGC 451



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 25/94 (26%)

Query: 71   CKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG-----SGFRVVVCP---LP------ 116
            C + C  G   D+C+     + + +NG + D ++G      G+  + C    LP      
Sbjct: 1029 CLQACPAGLYGDNCRH----SCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAG 1084

Query: 117  ------CMNGGQCSSRN-QCLCPPDFTGRFCQVP 143
                  C+NGG C     +CLCP  +TG  CQ P
Sbjct: 1085 CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSP 1118



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 29/106 (27%), Positives = 39/106 (36%), Gaps = 27/106 (25%)

Query: 66   FAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG-----SGFRVVVCPLPCMNG 120
            +A + C++ CL    R  C+          NG   D  TG     +G+    C  PC+ G
Sbjct: 1067 WAGLACEKECLPRDVRAGCRHSGGCL----NGGLCDPHTGRCLCPAGWTGDKCQSPCLRG 1122

Query: 121  G---QCSSR-------------NQCLCPPDFTGRFCQ--VPAGGAG 148
                 C+ R               C CPP FTG  C+   P G  G
Sbjct: 1123 WFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFG 1168



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 42/151 (27%), Positives = 59/151 (39%), Gaps = 28/151 (18%)

Query: 332  PVRGEVGADCPQGYKRLNSTHCQDINECAMPGV---CRH-GDCLN----NPGSYRCVCPP 383
            PV G     CP+G+  L    C+   EC    V   CRH G CLN    +P + RC+CP 
Sbjct: 1056 PVSGHCA--CPEGWAGLA---CE--KECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPA 1108

Query: 384  GHSLGPSRTQCI----ADKPEEKSLCFRLVSPEH-----QCQHPLTTRLTRQLC-CCSVG 433
            G +    ++ C+     +   ++  C    +  H     +C    T     Q C   S G
Sbjct: 1109 GWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFG 1168

Query: 434  KAWGARCQRCPTDGTAAFKE--ICPAGKGYH 462
            +     CQ CP +  A       C    GYH
Sbjct: 1169 EDCAQMCQ-CPGENPACHPATGTCSCAAGYH 1198



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 15/39 (38%), Positives = 17/39 (43%), Gaps = 2/39 (5%)

Query: 117 CMNGGQC--SSRNQCLCPPDFTGRFCQVPAGGAGGGTGG 153
           C +GG+C   S   C CPP F G  CQ          GG
Sbjct: 133 CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGG 171



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 29/105 (27%), Positives = 37/105 (35%), Gaps = 26/105 (24%)

Query: 71   CKRTCLKGQ----CRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG------ 120
            C+  C  G+    C   C   +N T     G       G GF    C  PC  G      
Sbjct: 1331 CELACPPGRYGAACHLECSCHNNSTCEPATGTCR---CGPGFYGQACEHPCPPGFHGAGC 1387

Query: 121  -GQCSSRN---------QCLCPPDFTGRFCQVPAGGAGGGTGGSG 155
             G C  ++         +CLCP  F G FC+    G   G+ G G
Sbjct: 1388 QGLCWCQHGAPCDPISGRCLCPAGFHGHFCE---RGCEPGSFGEG 1429


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  209 bits (533), Expect = 1e-53
 Identities = 132/338 (39%), Positives = 173/338 (51%), Gaps = 35/338 (10%)

Query: 599  CHCNPGYRSHPQHRYCVDVNEC--EAEPCGPGRGICMNTGGSYNCH----CNRGYRLHVG 652
            C C PGY        C D+NEC  +   C  G   C+NT GS++C+    C  GY L  G
Sbjct: 702  CSCFPGYAIMADGVSCEDINECVTDLHTCSRGEH-CVNTLGSFHCYKALTCEPGYALKDG 760

Query: 653  AGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKC----NCYPGYRLKASRPPVCEDIDEC 707
                 C D++ECA   H C  G  C N  G + C     C  G+         C DI+EC
Sbjct: 761  ----ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN--CVDINEC 814

Query: 708  RDPSS-C-PDGKCENKPGSFKC----IACQPGYR-SQGGGACRDVNECAEG-SPCSPGW- 758
               S  C P   C N  GS+ C    + C  GY  S  G  C DVNEC  G   C  G  
Sbjct: 815  TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 874

Query: 759  CENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYH 816
            C NLPGS+RC C  G+     GR C+DV+EC A  G +C +  C NT GS++C C SG+ 
Sbjct: 875  CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFL 933

Query: 817  LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPS 875
            L+ D   CED++EC+  A     +C N  GSY+C C QG++L   G  C DIDEC+Q   
Sbjct: 934  LAADGKRCEDVNECE--AQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAG 991

Query: 876  LCLPHGACKNLQGSYVCVC-DEGFTPTQDQHGCEEVEQ 912
            + L    C N+ GSY C C ++G+T T +   C++V++
Sbjct: 992  I-LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1028



 Score =  201 bits (511), Expect = 4e-51
 Identities = 133/345 (38%), Positives = 173/345 (50%), Gaps = 36/345 (10%)

Query: 574  ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECE--AEPCG 626
            + +EC  + + C  GE CV     + C+    C PGY        C DV+EC      C 
Sbjct: 719  DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQ 776

Query: 627  PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPG 681
            PG  +C NT GS+ C     C  G+ L    G  +CVD+NEC      C  G  CIN  G
Sbjct: 777  PGF-LCQNTKGSFYCQARQRCMDGF-LQDPEG--NCVDINECTSLSEPCRPGFSCINTVG 832

Query: 682  HYKCN-----CYPGYRLKASRPPVCEDIDECRDP-SSCPDGK-CENKPGSFKCIACQPGY 734
             Y C      C  GY         C D++EC      C +G+ C N PGS++C  C+ G+
Sbjct: 833  SYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRCGEGQVCHNLPGSYRC-DCKAGF 890

Query: 735  -RSQGGGACRDVNEC--AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
             R   G  C DVNEC  + G  C    CEN  GS+RC+CA G+  A DG+ C DV+ECEA
Sbjct: 891  QRDAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRCEDVNECEA 949

Query: 792  GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNGSYRC 850
                    C+N  GS+QC C  GY L+ D   C DIDEC   A  +    C+N  GSY+C
Sbjct: 950  QRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQC 1007

Query: 851  LCP-QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             CP QG+ +   GR C+D+DEC+     C     C N+QGS+ C+
Sbjct: 1008 ACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1052



 Score =  185 bits (469), Expect = 3e-46
 Identities = 157/481 (32%), Positives = 200/481 (41%), Gaps = 69/481 (14%)

Query: 616  DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGF 675
            D +EC   P    + +C+NT GSY+C C  G+ L     GR+C       +P    +   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ--DDGRTCRPEGHPPQPEAPQEPAL 661

Query: 676  CINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR 735
               F      N  P   L   +P  C+D   C+         C    GS  C +C PGY 
Sbjct: 662  KSEF-SQVASNTIP---LPLPQPNTCKDNGPCKQV-------CSTVGGSAIC-SCFPGYA 709

Query: 736  SQGGG-ACRDVNECAEG-SPCSPG-WCENLPGSFRC----TCAQGYAPAPDGRSCLDVDE 788
                G +C D+NEC      CS G  C N  GSF C    TC  GYA   DG  C DVDE
Sbjct: 710  IMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA-LKDGE-CEDVDE 767

Query: 789  CEAGD-VCDNG-ICSNTPGSFQCQ----CLSGYHLSRDRSHCEDIDEC-DFPAACIGG-D 840
            C  G   C  G +C NT GSF CQ    C+ G+ L     +C DI+EC      C  G  
Sbjct: 768  CAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFS 826

Query: 841  CINTNGSYRC-----LCPQG-HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC 894
            CINT GSY C     +C +G H    G KC D++EC      C     C NL GSY C C
Sbjct: 827  CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 886

Query: 895  DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG---AGWG 951
              GF       GC +V       EC+ +      C       +    C C+ G   A  G
Sbjct: 887  KAGFQRDAFGRGCIDV------NECWAS--PGRLCQHTCENTLGSYRCSCASGFLLAADG 938

Query: 952  DHCE-IYPCPVYSSAE--------FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGS 1002
              CE +  C     ++        +   C  G    +D +          DIDEC   G+
Sbjct: 939  KRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCT-------DIDECAQ-GA 990

Query: 1003 EICKEGKCVNTQPGYECYC-KQGFYYDGNLLECVDVDEC-LDESNCRNG-VCENTRGGYR 1059
             I    +C+N    Y+C C +QG+    N   C DVDEC L   NC     C N +G +R
Sbjct: 991  GILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFR 1050

Query: 1060 C 1060
            C
Sbjct: 1051 C 1051



 Score =  138 bits (348), Expect = 3e-32
 Identities = 143/496 (28%), Positives = 198/496 (39%), Gaps = 67/496 (13%)

Query: 349  NSTHCQDINECAM-PG-VCRHGDCLNNPGSYRCVC--------------PPGHSLGPSRT 392
            NS    D +EC + PG +C+H  C+N  GSY C C              P GH   P   
Sbjct: 598  NSLPGDDQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP 656

Query: 393  QCIADKPEEKSLCFRLV----------SPEHQCQHPLTTRLTRQLCCCSVGKAW---GAR 439
            Q  A K E   +    +               C+   +T     +C C  G A    G  
Sbjct: 657  QEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 440  CQ---RCPTD-GTAAFKEICPAGKG----YHILTSHQTLTIQ-GE----SDFSLFLHPDG 486
            C+    C TD  T +  E C    G    Y  LT      ++ GE     + ++  H   
Sbjct: 717  CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQ 776

Query: 487  PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRP 546
            P    Q  +        +   +  G   D    E   V  +  T+ + P RP    I+  
Sbjct: 777  PGFLCQNTKGSFYCQARQRCMD--GFLQDP---EGNCVDINECTSLSEPCRPGFSCINTV 831

Query: 547  SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGY 605
               T +   P +           T+  + +EC    + CG G+ C   P  Y C C  G+
Sbjct: 832  GSYTCQRN-PLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 890

Query: 606  RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
            +     R C+DVNEC A P    +  C NT GSY C C  G+ L   A G+ C D+NEC 
Sbjct: 891  QRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL--AADGKRCEDVNECE 948

Query: 666  KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGS 724
                  +   C N  G Y+C C  GY+L A     C DIDEC   +      +C N PGS
Sbjct: 949  AQRCSQE---CANIYGSYQCYCRQGYQL-AEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1004

Query: 725  FKCIACQPGY-RSQGGGACRDVNECAEGS-PCSPG-WCENLPGSFRC---TCAQGYAPAP 778
            ++C   + GY  +  G +C+DV+ECA G+  CS    C N+ GSFRC    C   Y    
Sbjct: 1005 YQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVS 1064

Query: 779  ----DGRSCLDVDECE 790
                +  +C D  EC+
Sbjct: 1065 KTKCERTTCHDFLECQ 1080



 Score =  125 bits (313), Expect = 3e-28
 Identities = 191/812 (23%), Positives = 273/812 (33%), Gaps = 195/812 (24%)

Query: 484  PDGPPKPQ-------QLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPA 536
            P  P KP         LP++ +  PP  +   +  V   S V E+      H    ++P 
Sbjct: 377  PRDPVKPSPHNILSTSLPDA-AWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPE 435

Query: 537  RPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPD 596
                +LI        +W + +       +EI P   TE + CR  Q  C    CV    +
Sbjct: 436  GSTKDLIETCCAAGQQWAIDN----DECLEI-PESGTEDNVCRTAQRHC----CVSYLQE 486

Query: 597  YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
             SC                 +   E E CG              C    G  L V A G+
Sbjct: 487  KSCMAGV-------------LGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 657  SCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            SC      + P+L    G+  N   H   +C  G       P +  ++    +P++ P  
Sbjct: 534  SCE-----SNPNL----GYPCN---HVMLSCCEG-----EEPLIVPEVRRPPEPAAAPRR 576

Query: 717  KCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAP 776
              E                           E A     S G    LP S          P
Sbjct: 577  VSEA--------------------------EMAGREALSLGTEAELPNSL---------P 601

Query: 777  APDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC------------ 824
              D   CL +     G++C + +C NT GS+ C C  G+ L  D   C            
Sbjct: 602  GDDQDECLLLP----GELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP 656

Query: 825  -EDIDECDF--------------PAACIGGD-----CINTNGSYRCLCPQGHRLVG-GRK 863
             E   + +F              P  C         C    GS  C C  G+ ++  G  
Sbjct: 657  QEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 864  CQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDEGFTPTQDQHGCEEVEQPHHKKEC 919
            C+DI+EC  D   C     C N  GS+ C     C+ G+     +  CE+V+      EC
Sbjct: 717  CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVD------EC 768

Query: 920  YLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ 979
                         + T+  Q    C    G   +C+               C DG     
Sbjct: 769  ------------AMGTHTCQPGFLCQNTKG-SFYCQA-----------RQRCMDGFLQDP 804

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECY-----CKQGFYYDGNLLE 1033
            + N V        DI+EC    SE C+ G  C+NT   Y C      C +G++   +  +
Sbjct: 805  EGNCV--------DINECTSL-SEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK 855

Query: 1034 CVDVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVC 1091
            CVDV+EC      C  G VC N  G YRC C    +     R C+   E          C
Sbjct: 856  CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE----------C 905

Query: 1092 WSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1151
            W+  G   +C         ++  C C  G    A  + C           SQ  +N +  
Sbjct: 906  WASPGR--LCQHTCENTLGSYR-CSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGS 962

Query: 1152 TSPLLL-GKPPRDEDSSEEDSDECRCVSG-----RCVPRPGGAVCECPG-GFQLDASRAR 1204
                   G    ++  +  D DEC   +G     RC+  PG   C CP  G+ + A+   
Sbjct: 963  YQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRS 1022

Query: 1205 CVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
            C D+DEC          ++E C N  GSFRC+
Sbjct: 1023 CKDVDECALGTHN--CSEAETCHNIQGSFRCL 1052



 Score =  106 bits (264), Expect = 2e-22
 Identities = 112/396 (28%), Positives = 158/396 (39%), Gaps = 87/396 (21%)

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE---EVEQPHHKKECYLN 922
            D DEC   P     H  C N  GSY C C  GF+   D   C       QP   +E  L 
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 923  FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP-VYSSAEFHSLCPDGKGYTQDN 981
             + +    + +   + Q   C   G          PC  V S+    ++C    GY    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNG----------PCKQVCSTVGGSAICSCFPGYA--- 709

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYY-DGNLLECV 1035
             I+  G+    DI+EC+      C  G+ CVNT   + CY    C+ G+   DG   EC 
Sbjct: 710  -IMADGVSCE-DINECVT-DLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG---ECE 763

Query: 1036 DVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWS 1093
            DVDEC +    C+ G +C+NT+G + C          A+++C+                 
Sbjct: 764  DVDECAMGTHTCQPGFLCQNTKGSFYCQ---------ARQRCM----------------- 797

Query: 1094 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1153
                DG    P  G  +  ++C         +   PC P   G  C  +          +
Sbjct: 798  ----DGFLQDP-EGNCVDINECT--------SLSEPCRP---GFSCINTVGSYTC--QRN 839

Query: 1154 PLLL--GKPPRDEDSSEEDSDEC-----RCVSGR-CVPRPGGAVCECPGGFQLDASRARC 1205
            PL+   G    D+ +   D +EC     RC  G+ C   PG   C+C  GFQ DA    C
Sbjct: 840  PLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGC 899

Query: 1206 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            +D++EC      G LC+   C NT GS+RC C +GF
Sbjct: 900  IDVNEC--WASPGRLCQ-HTCENTLGSYRCSCASGF 932



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/310 (23%), Positives = 104/310 (33%), Gaps = 64/310 (20%)

Query: 993  DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC------------------ 1034
            D DEC+L   E+C+   C+NT   Y C C  GF    +   C                  
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 1035 ---------------VDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
                              + C D   C+  VC    G   C+C P          C   E
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIMADGVSC---E 718

Query: 1080 EMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGW-GAQCRPCPPRGAGSH 1138
            ++         C   RGE   C   L G    +    C  G      +C        G+H
Sbjct: 719  DINECVTDLHTC--SRGEH--CVNTL-GSFHCYKALTCEPGYALKDGECEDVDECAMGTH 773

Query: 1139 -CPTS---QSESNSFW-DTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP------RPGG 1187
             C      Q+   SF+       +    +D + +  D +EC  +S  C P        G 
Sbjct: 774  TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGS 833

Query: 1188 AVCE-----CPGGFQLDASRARCVDIDECRELNQRGLLC-KSERCVNTSGSFRCVCKAGF 1241
              C+     C  G+       +CVD++EC     R   C + + C N  GS+RC CKAGF
Sbjct: 834  YTCQRNPLICARGYHASDDGTKCVDVNECETGVHR---CGEGQVCHNLPGSYRCDCKAGF 890

Query: 1242 ARSRPHGACV 1251
             R      C+
Sbjct: 891  QRDAFGRGCI 900



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 47/147 (31%), Positives = 59/147 (40%), Gaps = 24/147 (16%)

Query: 341 CPQGYKRLNS-THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIA 396
           C +GY   +  T C D+NEC   GV R G+   C N PGSYRC C  G         CI 
Sbjct: 843 CARGYHASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI- 900

Query: 397 DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARC--------QRCPT 445
               + + C+   SP   CQH     L    C C+ G    A G RC        QRC  
Sbjct: 901 ----DVNECW--ASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ 954

Query: 446 DGTAAFKEI-CPAGKGYHILTSHQTLT 471
           +    +    C   +GY +     T T
Sbjct: 955 ECANIYGSYQCYCRQGYQLAEDGHTCT 981



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 12/119 (10%)

Query: 282 DTLPKQPCGSNPL---PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
           +T+    C  NPL    G    +D    +     ++  H+C + Q      PG  R    
Sbjct: 829 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCH-NLPGSYR---- 883

Query: 339 ADCPQGYKR-LNSTHCQDINEC-AMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            DC  G++R      C D+NEC A PG +C+H  C N  GSYRC C  G  L     +C
Sbjct: 884 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRC 941



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCP-PG 384
            Q+   + G     C QGY+     H C DI+ECA   G+     CLN PGSY+C CP  G
Sbjct: 954  QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQG 1013

Query: 385  HSLGPSRTQC 394
            +++  +   C
Sbjct: 1014 YTMTANGRSC 1023



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 8/69 (11%)

Query: 333  VRGEVGADCP-QGYKRL-NSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCV---CPPGH 385
            V G     CP QGY    N   C+D++ECA+    C   + C N  GS+RC+   CPP +
Sbjct: 1001 VPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1060

Query: 386  SLGPSRTQC 394
             +  S+T+C
Sbjct: 1061 -VQVSKTKC 1068



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 58/227 (25%), Positives = 75/227 (33%), Gaps = 41/227 (18%)

Query: 1035 VDVDECLD--ESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERA-PERRDVC 1091
            +D DECL+  ES   + VC   R   R  C    +        L  +E E    E  D C
Sbjct: 454  IDNDECLEIPESGTEDNVC---RTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSC 510

Query: 1092 WSQRGEDGMCAGPLAGPALTFDDC-CCRQG---RGWGAQCRPCPPRGAG-SHCPTSQSES 1146
                           G +L    C CC  G   R  G  C   P  G   +H   S  E 
Sbjct: 511  ---------------GISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEG 555

Query: 1147 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCV 1206
                   PL++ +  R  + +                   G   E P     D       
Sbjct: 556  EE-----PLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGD------- 603

Query: 1207 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1253
            D DEC  L   G LC+   C+NT GS+ C C  GF+       C P+
Sbjct: 604  DQDECLLLP--GELCQ-HLCINTVGSYHCACFPGFSLQDDGRTCRPE 647



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 42/157 (26%), Positives = 57/157 (36%), Gaps = 26/157 (16%)

Query: 234 HPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS-- 291
           HPP+          S     A +   LP P+P+     T K  G C      KQ C +  
Sbjct: 649 HPPQPEAPQEPALKSEFSQVASNTIPLPLPQPN-----TCKDNGPC------KQVCSTVG 697

Query: 292 -----NPLPGLTKQED--CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQG 344
                +  PG     D   C  I      +  H C + ++  V   G         C  G
Sbjct: 698 GSAICSCFPGYAIMADGVSCEDINEC--VTDLHTCSRGEHC-VNTLGSFHCYKALTCEPG 754

Query: 345 YKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRC 379
           Y  L    C+D++ECAM    C+ G  C N  GS+ C
Sbjct: 755 YA-LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC 790


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  207 bits (528), Expect = 4e-53
 Identities = 210/710 (29%), Positives = 289/710 (40%), Gaps = 150/710 (21%)

Query: 569  PTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
            PT ++E +EC  N N C HG C      Y C C+PG+         ++ NECE+ PC  G
Sbjct: 711  PTCLSEVNEC--NSNPCVHGACRDSLNGYKCDCDPGWSGT---NCDINNNECESNPCVNG 765

Query: 629  RGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNC 687
             G C +    Y C C  G+       G +C  ++NECA  + C + G CI+    YKCNC
Sbjct: 766  -GTCKDMTSGYVCTCREGF------SGPNCQTNINECAS-NPCLNQGTCIDDVAGYKCNC 817

Query: 688  YPGYRLKASRPPVCEDIDECRDPSSCPDG-KCENKPG--SFKCIACQPGYRSQGGGACR- 743
               Y         CE +     PS C +G +C       SF C+ C  G++ Q    C  
Sbjct: 818  LLPYT-----GATCEVVLAPCAPSPCRNGGECRQSEDYESFSCV-CPTGWQGQ---TCEV 868

Query: 744  DVNECAEGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICS 801
            D+NEC   SPC  G  C+N  G +RC C  GY+    GR+C  D+D+C      + G C+
Sbjct: 869  DINECVL-SPCRHGASCQNTHGGYRCHCQAGYS----GRNCETDIDDCRPNPCHNGGSCT 923

Query: 802  NTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG 860
            +   +  C CL G+      + CE DI+EC       G +C +   SY C CP G     
Sbjct: 924  DGINTAFCDCLPGFR----GTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGF---S 976

Query: 861  GRKCQD-IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919
            G  C++   +C++  S C   G C +   S+ C+C  GFT +  QH   E +     + C
Sbjct: 977  GIHCENNTPDCTE--SSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDS----QPC 1030

Query: 920  YLNFDDTVFCDSVLAT---NVTQQEC-----------CCSLGAGWGDHCEIYPCPVYSSA 965
                     C S   T     T   C           C + G  W  H + Y C      
Sbjct: 1031 LHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ-YRCE----- 1084

Query: 966  EFHSLCPDG-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQ 1023
                 CP G  G   D   V+  + A R   +     + +C+ G  CV+    + C C+ 
Sbjct: 1085 -----CPSGWTGLYCDVPSVSCEVAAQRQGVDV----ARLCQHGGLCVDAGNTHHCRCQA 1135

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEEME 1082
            G  Y G+  E + VDEC   S C+NG  C +  GGY C C   A Y              
Sbjct: 1136 G--YTGSYCEDL-VDEC-SPSPCQNGATCTDYLGGYSCKCV--AGYHGVN---------- 1179

Query: 1083 RAPERRDVCWSQRGEDGMCAGPLAGPALTFDD---CCCRQGRGWGAQCRPCPPRGA-GSH 1138
               E  D C S   ++G       G  L   +   C C              PRG  G H
Sbjct: 1180 -CSEEIDECLSHPCQNG-------GTCLDLPNTYKCSC--------------PRGTQGVH 1217

Query: 1139 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1198
            C  +  + N            PP D  S    S +C   +G CV + GG  C CP GF  
Sbjct: 1218 CEINVDDCN------------PPVDPVSR---SPKC-FNNGTCVDQVGGYSCTCPPGFVG 1261

Query: 1199 DASRARCV-DIDEC--RELNQRGLLCKSERCVNTSGSFRCVCKAGFARSR 1245
            +    RC  D++EC     + RG    ++ CV     F C C+AG    R
Sbjct: 1262 E----RCEGDVNECLSNPCDARG----TQNCVQRVNDFHCECRAGHTGRR 1303



 Score =  202 bits (514), Expect = 2e-51
 Identities = 211/798 (26%), Positives = 296/798 (37%), Gaps = 186/798 (23%)

Query: 569  PTQVTETDECRLNQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP 627
            P    + DEC L  N C H G+C+     + C C  GY      R  +DVNEC + PC  
Sbjct: 407  PACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTG---PRCEIDVNECVSNPC-Q 462

Query: 628  GRGICMNTGGSYNCHCNRGYR----------------LH----------------VGAGG 655
                C++  G + C C  GY                 LH                 G  G
Sbjct: 463  NDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTG 522

Query: 656  RSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE-DIDECRDPSSC 713
              C  D++ECA    C +G  C++ P  Y C C  GY         CE DIDEC DP  C
Sbjct: 523  HLCQYDVDECASTP-CKNGAKCLDGPNTYTCVCTEGY-----TGTHCEVDIDEC-DPDPC 575

Query: 714  PDGKCENKPGSFKCIACQPGYRS---------------QGGGACRD-------------- 744
              G C++   +F C+ C+PGY                 + GG C+D              
Sbjct: 576  HYGSCKDGVATFTCL-CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTT 634

Query: 745  -------VNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCD 796
                   +++CA  SPC  G C +    + C C  GY     G  C +++DEC AG+ C 
Sbjct: 635  GPNCEINLDDCA-SSPCDSGTCLDKIDGYECACEPGYT----GSMCNINIDEC-AGNPCH 688

Query: 797  N-GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQG 855
            N G C +    F C+C  GYH   D +   +++EC+    C+ G C ++   Y+C C  G
Sbjct: 689  NGGTCEDGINGFTCRCPEGYH---DPTCLSEVNECN-SNPCVHGACRDSLNGYKCDCDPG 744

Query: 856  HRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT--------------P 900
                 G  C  + +EC  +P  C+  G CK++   YVC C EGF+              P
Sbjct: 745  W---SGTNCDINNNECESNP--CVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNP 799

Query: 901  TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
              +Q  C + +   +K  C L +     C+ VLA        C       G  C      
Sbjct: 800  CLNQGTCID-DVAGYKCNCLLPYTGAT-CEVVLAP-------CAPSPCRNGGECR--QSE 848

Query: 961  VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYEC 1019
             Y S  F  +CP G            G     DI+EC+L     C+ G  C NT  GY C
Sbjct: 849  DYES--FSCVCPTGW----------QGQTCEVDINECVL---SPCRHGASCQNTHGGYRC 893

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
            +C+ G  Y G   E  D+D+C        G C +      C C P    +  +       
Sbjct: 894  HCQAG--YSGRNCE-TDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDI---N 947

Query: 1080 EMERAPERRDVCWSQRGEDGMCAGPLAGPALTFD----DC----CCRQGR---GWGAQCR 1128
            E    P R     +   +   C  P     +  +    DC    C   G    G  +   
Sbjct: 948  ECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTC 1007

Query: 1129 PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEE------------------- 1169
             CPP   GS+C    +E     D+ P L G   +D   S                     
Sbjct: 1008 LCPPGFTGSYCQHDVNEC----DSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWC 1063

Query: 1170 DSDECRCVSGRCVPRPGGAVCECPGGF---QLDASRARCVDIDECRELNQRGLLCKSERC 1226
            DS  C+   G+C        CECP G+     D     C    + + ++   L      C
Sbjct: 1064 DSSPCK-NGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLC 1122

Query: 1227 VNTSGSFRCVCKAGFARS 1244
            V+   +  C C+AG+  S
Sbjct: 1123 VDAGNTHHCRCQAGYTGS 1140



 Score =  191 bits (486), Expect = 3e-48
 Identities = 196/768 (25%), Positives = 295/768 (38%), Gaps = 160/768 (20%)

Query: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYC-VDVNECEAEPCGPGRGIC 632
            + DEC  + + C +G C  G   ++C C PGY  H    +C  ++NEC ++PC  G G C
Sbjct: 566  DIDEC--DPDPCHYGSCKDGVATFTCLCRPGYTGH----HCETNINECSSQPCRHG-GTC 618

Query: 633  MNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY 691
             +   +Y C C +      G  G +C ++L++CA      D G C++    Y+C C PGY
Sbjct: 619  QDRDNAYLCFCLK------GTTGPNCEINLDDCASSPC--DSGTCLDKIDGYECACEPGY 670

Query: 692  RLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG------------ 738
                    +C  +IDEC        G CE+    F C  C  GY                
Sbjct: 671  -----TGSMCNINIDECAGNPCHNGGTCEDGINGFTC-RCPEGYHDPTCLSEVNECNSNP 724

Query: 739  --GGACRDV---------------------NECAEGSPC-SPGWCENLPGSFRCTCAQGY 774
               GACRD                      NEC E +PC + G C+++   + CTC +G+
Sbjct: 725  CVHGACRDSLNGYKCDCDPGWSGTNCDINNNEC-ESNPCVNGGTCKDMTSGYVCTCREGF 783

Query: 775  APAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFP 833
            +    G +C  +++EC +    + G C +    ++C CL  Y      + CE +     P
Sbjct: 784  S----GPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPY----TGATCEVVLAPCAP 835

Query: 834  AAC-IGGDCINTNG--SYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGS 889
            + C  GG+C  +    S+ C+CP G +   G+ C+ DI+EC   P  C    +C+N  G 
Sbjct: 836  SPCRNGGECRQSEDYESFSCVCPTGWQ---GQTCEVDINECVLSP--CRHGASCQNTHGG 890

Query: 890  YVCVCDEGFTPTQDQHGCEEVE-QPHHKKECYLNFDDTVFCDSVLATNVT-----QQECC 943
            Y C C  G++    +   ++    P H      +  +T FCD +     T       EC 
Sbjct: 891  YRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECA 950

Query: 944  ---CSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLF 1000
               C  GA   D  + Y C           CP G            GI    +  +C   
Sbjct: 951  SDPCRNGANCTDCVDSYTC----------TCPAGFS----------GIHCENNTPDCT-- 988

Query: 1001 GSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRC 1060
             S     G CV+    + C C  GF   G+  +  DV+EC  +     G C++  G YRC
Sbjct: 989  ESSCFNGGTCVDGINSFTCLCPPGF--TGSYCQ-HDVNECDSQPCLHGGTCQDGCGSYRC 1045

Query: 1061 ACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAG-------PALTFD 1113
             C  P  Y+    Q L         +    CW Q      C  P          P+++ +
Sbjct: 1046 TC--PQGYTGPNCQNLVHWCDSSPCKNGGKCW-QTHTQYRCECPSGWTGLYCDVPSVSCE 1102

Query: 1114 DCCCRQGRGWGAQCRP---CPPRGAGSHCPTSQSESNSFWD-------TSPLLLGKPPRD 1163
                RQG      C+    C   G   HC      + S+ +        SP   G    D
Sbjct: 1103 VAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTD 1162

Query: 1164 --------------EDSSEEDSDEC---RCVS-GRCVPRPGGAVCECPGGFQLDASRARC 1205
                            +  E+ DEC    C + G C+  P    C CP G Q       C
Sbjct: 1163 YLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQ----GVHC 1218

Query: 1206 -VDIDECR----ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248
             +++D+C      +++      +  CV+  G + C C  GF   R  G
Sbjct: 1219 EINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEG 1266



 Score =  186 bits (471), Expect = 2e-46
 Identities = 213/780 (27%), Positives = 287/780 (36%), Gaps = 206/780 (26%)

Query: 593  GPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVG 652
            G  DY+C C  G+ S P     +D N C   PC  G    + T   Y C C  G+     
Sbjct: 81   GVADYACSCALGF-SGPLCLTPLD-NACLTNPCRNGGTCDLLTLTEYKCRCPPGW----- 133

Query: 653  AGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVC-EDIDEC-RDP 710
              G+SC   + CA  + C +GG C+ F   Y C+C P +       P C +D++EC + P
Sbjct: 134  -SGKSCQQADPCAS-NPCANGGQCLPFEASYICHCPPSF-----HGPTCRQDVNECGQKP 186

Query: 711  SSC-PDGKCENKPGSFKCIA---------------CQPGYRSQGGGACRDVNECAEGSPC 754
              C   G C N+ GS++C+                C P    Q GG CR   +      C
Sbjct: 187  GLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPS-PCQNGGTCRPTGDVTHECAC 245

Query: 755  SPGW----CE----NLPG--------------SFRCTCAQGYAPAPDGRSCL-DVDECE- 790
             PG+    CE    + PG              ++ C C     P   G+ C  DVDEC+ 
Sbjct: 246  LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRC----PPEWTGQYCTEDVDECQL 301

Query: 791  AGDVCDN-GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA--------------- 834
              + C N G C NT G + C C++G+    D S  E+ID+C   A               
Sbjct: 302  MPNACQNGGTCHNTHGGYNCVCVNGW-TGEDCS--ENIDDCASAACFHGATCHDRVASFY 358

Query: 835  ----------------ACIGGDCIN--------TNGSYRCLCPQGHRLVGGRKCQDIDEC 870
                            ACI   C           NG   C CP G+   G    QD+DEC
Sbjct: 359  CECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGY--TGPACSQDVDEC 416

Query: 871  SQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCD 930
            S   + C   G C N  GS+ C C +G+T  +    CE         EC  N       D
Sbjct: 417  SLGANPCEHAGKCINTLGSFECQCLQGYTGPR----CE-----IDVNECVSNPCQN---D 464

Query: 931  SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSA------------EFHSLCPDGKGYT 978
            +     + + +C C  G   G HCE+      SS             EF   CP   G+T
Sbjct: 465  ATCLDQIGEFQCICMPGYE-GVHCEVNTDECASSPCLHNGRCLDKINEFQCECP--TGFT 521

Query: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDV 1037
                    G     D+DEC    S  CK G KC++    Y C C +G  Y G   E VD+
Sbjct: 522  --------GHLCQYDVDEC---ASTPCKNGAKCLDGPNTYTCVCTEG--YTGTHCE-VDI 567

Query: 1038 DECLDESNCRNGVCENTRGGYRCACTP-----------------PAEYSPAQRQ------ 1074
            DEC D   C  G C++    + C C P                 P  +    +       
Sbjct: 568  DEC-DPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYL 626

Query: 1075 --CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPP 1132
              CL            D C S   + G C   + G      +C C  G   G+ C     
Sbjct: 627  CFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDG-----YECACEPGY-TGSMCNINID 680

Query: 1133 RGAGSHC---PTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAV 1189
              AG+ C    T +   N F    P     P    + +E +S+   CV G C     G  
Sbjct: 681  ECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNP--CVHGACRDSLNGYK 738

Query: 1190 CECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN-------TSGSFRCVCKAGFA 1242
            C+C  G+    S   C DI+           C+S  CVN       TSG + C C+ GF+
Sbjct: 739  CDCDPGW----SGTNC-DINNNE--------CESNPCVNGGTCKDMTSG-YVCTCREGFS 784



 Score =  137 bits (345), Expect = 6e-32
 Identities = 156/593 (26%), Positives = 220/593 (37%), Gaps = 98/593 (16%)

Query: 695  ASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPC 754
            A+R P C    E    +    GKCE   G+  C+ C   +    G  C+D N C   +PC
Sbjct: 18   AARGPRCSQPGE----TCLNGGKCEAANGTEACV-CGGAFV---GPRCQDPNPCLS-TPC 68

Query: 755  -SPGWCENLP----GSFRCTCAQGYAP----APDGRSCLDVDECEAGDVCDNGICSNTPG 805
             + G C  +       + C+CA G++      P   +CL  + C  G  CD      T  
Sbjct: 69   KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACL-TNPCRNGGTCD----LLTLT 123

Query: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC- 864
             ++C+C  G+        C+  D C       GG C+    SY C CP       G  C 
Sbjct: 124  EYKCRCPPGW----SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH---GPTCR 176

Query: 865  QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFD 924
            QD++EC Q P LC   G C N  GSY CVC      T     CE    P     C     
Sbjct: 177  QDVNECGQKPGLCRHGGTCHNEVGSYRCVC----RATHTGPNCERPYVPCSPSPCQNG-- 230

Query: 925  DTVFCDSVLATNVTQQECCCSLGAGWGDHCE--IYPCPVYSSAEFHSLCPDGKGYTQDNN 982
                  +   T     EC C L    G +CE  I  CP        + C +G       N
Sbjct: 231  -----GTCRPTGDVTHECAC-LPGFTGQNCEENIDDCP-------GNNCKNGGACVDGVN 277

Query: 983  IVNYGIPAH-------RDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG---NLL 1032
              N   P          D+DEC L  +     G C NT  GY C C  G+  +    N+ 
Sbjct: 278  TYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENID 337

Query: 1033 ECVDVDECLDESNCRNGV------CENTRGGYRC----AC--TPPAEYSPAQRQCLSPEE 1080
            +C     C   + C + V      C + R G  C    AC   P  E S      ++ + 
Sbjct: 338  DCASA-ACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKA 396

Query: 1081 MERAPE--RRDVCWSQRGEDGMCAGPL--AGP---ALTFDDCCCRQGRGWGAQCRPCPPR 1133
            +   P       C     E  + A P   AG     L   +C C QG   G +C      
Sbjct: 397  ICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY-TGPRCEIDVNE 455

Query: 1134 GAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR---CV-SGRCVPRPGGAV 1189
               + C    +  +   +   + +  P  +    E ++DEC    C+ +GRC+ +     
Sbjct: 456  CVSNPCQNDATCLDQIGEFQCICM--PGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQ 513

Query: 1190 CECPGGFQLDASRARCVDIDECRELNQRGLLCKS-ERCVNTSGSFRCVCKAGF 1241
            CECP GF          D+DEC         CK+  +C++   ++ CVC  G+
Sbjct: 514  CECPTGF---TGHLCQYDVDECASTP-----CKNGAKCLDGPNTYTCVCTEGY 558



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 70/277 (25%), Positives = 101/277 (36%), Gaps = 35/277 (12%)

Query: 574  ETDECRLNQ-NICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDV-NECEAEPCGPGR-- 629
            + +EC  N  +  G   CV    D+ C C  G+      R C  V N C+ +PC  G   
Sbjct: 1267 DVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTG----RRCESVINGCKGKPCKNGGTC 1322

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY- 688
             +  NT   + C C  G+       G +C +         C +GG CI+ P    C C  
Sbjct: 1323 AVASNTARGFICKCPAGFE------GATCENDARTCGSLRCLNGGTCISGPRSPTCLCLG 1376

Query: 689  ----PGYRLKASRPPV----CEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG 740
                P  +  AS P +    C +   C   S  P  +C   P  F  + C     S GGG
Sbjct: 1377 PFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLC-PAKFNGLLCHILDYSFGGG 1435

Query: 741  ACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSC-LDVDE----CEAGDV 794
            A RD+        C    C+   G+  C+     +A   DG  C L+ ++    C     
Sbjct: 1436 AGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQ 1495

Query: 795  C----DNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
            C     +G C +   S  C    G+   R    C  +
Sbjct: 1496 CWKYFSDGHCDSQCNSAGC-LFDGFDCQRAEGQCNPL 1531



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 50/124 (40%), Gaps = 13/124 (10%)

Query: 341 CPQGYKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCVCPPGHSLGPS----RTQC 394
           CP  +     T  QD+NEC   PG+CRHG  C N  GSYRCVC   H+ GP+       C
Sbjct: 166 CPPSFH--GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHT-GPNCERPYVPC 222

Query: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQR--CPTDGTAAFK 452
                +    C       H+C        T Q C  ++    G  C+      DG   + 
Sbjct: 223 SPSPCQNGGTCRPTGDVTHEC--ACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYN 280

Query: 453 EICP 456
             CP
Sbjct: 281 CRCP 284



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 10/90 (11%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAM-PGVCRH-GDCLNNPGSYRCVCPPGHSLGP 389
           PV G+    CP GY        QD++EC++    C H G C+N  GS+ C C  G++ GP
Sbjct: 391 PVNGKAICTCPSGYT--GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT-GP 447

Query: 390 ----SRTQCIADKPEEKSLCFRLVSPEHQC 415
                  +C+++  +  + C   +  E QC
Sbjct: 448 RCEIDVNECVSNPCQNDATCLDQIG-EFQC 476



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 36/134 (26%), Positives = 52/134 (38%), Gaps = 20/134 (14%)

Query: 335 GEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHS---LGPS 390
           G     C QGY       C+ D+NEC          CL+  G ++C+C PG+       +
Sbjct: 434 GSFECQCLQGY---TGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVN 490

Query: 391 RTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC------CCSVGKAWGARCQRCP 444
             +C +        C   ++ E QC+ P  T  T  LC      C S     GA+C    
Sbjct: 491 TDECASSPCLHNGRCLDKIN-EFQCECP--TGFTGHLCQYDVDECASTPCKNGAKC---- 543

Query: 445 TDGTAAFKEICPAG 458
            DG   +  +C  G
Sbjct: 544 LDGPNTYTCVCTEG 557



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 34/118 (28%)

Query: 341  CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
            CP G+     ++CQ D+NEC        G C +  GSYRC CP G++ GP+         
Sbjct: 1009 CPPGF---TGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYT-GPN--------- 1055

Query: 400  EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQ---RCPTDGTAAFKEI 454
                 C  LV   H C             C + GK W    Q    CP+  T  + ++
Sbjct: 1056 -----CQNLV---HWCD---------SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDV 1096



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 38/119 (31%), Positives = 44/119 (36%), Gaps = 34/119 (28%)

Query: 289 CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP-QLQYTGVQ--------KPGPVRG---- 335
           C SNP          C + GT       +KC   L YTG           P P R     
Sbjct: 795 CASNP----------CLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGEC 844

Query: 336 -------EVGADCPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHS 386
                       CP G++    T   DINEC +   CRHG  C N  G YRC C  G+S
Sbjct: 845 RQSEDYESFSCVCPTGWQ--GQTCEVDINECVL-SPCRHGASCQNTHGGYRCHCQAGYS 900



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 18/47 (38%), Positives = 28/47 (59%), Gaps = 5/47 (10%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
           C +GY     THC+ DI+EC  P  C +G C +   ++ C+C PG++
Sbjct: 554 CTEGY---TGTHCEVDIDECD-PDPCHYGSCKDGVATFTCLCRPGYT 596



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 37/118 (31%), Positives = 50/118 (42%), Gaps = 17/118 (14%)

Query: 354 QDINECA-MPGVCRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCF----- 406
           +D++EC  MP  C++G  C N  G Y CVC  G + G   ++ I D     + CF     
Sbjct: 294 EDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWT-GEDCSENIDDC--ASAACFHGATC 350

Query: 407 --RLVSPEHQCQHPLTTRLTR-QLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461
             R+ S   +C H  T  L      C S     G+ C   P +G    K IC    GY
Sbjct: 351 HDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNG----KAICTCPSGY 404



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 42/138 (30%), Positives = 55/138 (39%), Gaps = 38/138 (27%)

Query: 340  DCPQGYKRLNSTHCQ-DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIAD 397
            DC  G++    T C+ DINECA    CR+G +C +   SY C CP G     S   C  +
Sbjct: 932  DCLPGFR---GTFCEEDINECASDP-CRNGANCTDCVDSYTCTCPAGF----SGIHCENN 983

Query: 398  KPE-EKSLCFR-------------LVSP---EHQCQHPLTTRLTRQLCCCSVGKAWGARC 440
             P+  +S CF              L  P      CQH +         C S     G  C
Sbjct: 984  TPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNE-------CDSQPCLHGGTC 1036

Query: 441  QRCPTDGTAAFKEICPAG 458
            Q    DG  +++  CP G
Sbjct: 1037 Q----DGCGSYRCTCPQG 1050



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 3/46 (6%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
           CP+GY   + T   ++NEC     C HG C ++   Y+C C PG S
Sbjct: 704 CPEGYH--DPTCLSEVNECNS-NPCVHGACRDSLNGYKCDCDPGWS 746



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
           CP G+   +   CQ  + CA       G CL    SY C CPP    GP+  Q + +  +
Sbjct: 129 CPPGW---SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH-GPTCRQDVNECGQ 184

Query: 401 EKSLC 405
           +  LC
Sbjct: 185 KPGLC 189



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 38/130 (29%), Positives = 54/130 (41%), Gaps = 19/130 (14%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGD-CLNNPGSYRCVCPPGHSLGPS---RTQCI 395
           C  GY      HC+ +INEC+    CRHG  C +   +Y C C  G + GP+        
Sbjct: 591 CRPGY---TGHHCETNINECSSQP-CRHGGTCQDRDNAYLCFCLKG-TTGPNCEINLDDC 645

Query: 396 ADKPEEKSLCF-RLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT--DGTAAFK 452
           A  P +   C  ++   E  C+       T  +C  ++ +  G  C    T  DG   F 
Sbjct: 646 ASSPCDSGTCLDKIDGYECACE----PGYTGSMCNINIDECAGNPCHNGGTCEDGINGFT 701

Query: 453 EICPAGKGYH 462
             CP  +GYH
Sbjct: 702 CRCP--EGYH 709



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 24/71 (33%), Positives = 32/71 (45%), Gaps = 14/71 (19%)

Query: 82   DSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCP--------LPCMNGGQCS---SRNQCL 130
            D C+ G+N T   ++   T     +GF  + C           C NGG C    +   CL
Sbjct: 952  DPCRNGANCTDCVDSYTCT---CPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCL 1008

Query: 131  CPPDFTGRFCQ 141
            CPP FTG +CQ
Sbjct: 1009 CPPGFTGSYCQ 1019



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 22/66 (33%), Positives = 30/66 (45%), Gaps = 8/66 (12%)

Query: 336 EVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           E   +CP G+       CQ D++ECA         CL+ P +Y CVC  G+    + T C
Sbjct: 511 EFQCECPTGF---TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY----TGTHC 563

Query: 395 IADKPE 400
             D  E
Sbjct: 564 EVDIDE 569



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 14/32 (43%), Positives = 21/32 (65%), Gaps = 3/32 (9%)

Query: 116  PCMNGGQC---SSRNQCLCPPDFTGRFCQVPA 144
            PC NGG+C    ++ +C CP  +TG +C VP+
Sbjct: 1067 PCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS 1098



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            G     C  GY  +N +  ++I+EC        G CL+ P +Y+C CP G
Sbjct: 1165 GGYSCKCVAGYHGVNCS--EEIDECLSHPCQNGGTCLDLPNTYKCSCPRG 1212



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 5/46 (10%)

Query: 116  PCMNGGQCSSRNQ-----CLCPPDFTGRFCQVPAGGAGGGTGGSGP 156
            PC N G C   ++     CLCP  F G  C +     GGG G   P
Sbjct: 1396 PCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIP 1441



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 20/50 (40%), Positives = 22/50 (44%), Gaps = 8/50 (16%)

Query: 116 PCMNGGQC---SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTG 162
           PC NGGQC    +   C CPP F G  C+           G  PGL R G
Sbjct: 148 PCANGGQCLPFEASYICHCPPSFHGPTCRQDVNEC-----GQKPGLCRHG 192



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 21/66 (31%), Positives = 28/66 (42%), Gaps = 9/66 (13%)

Query: 84  CQQGSNMTLIGENGHSTDTL---TGSGFRVVVCPLP---CMNGGQCS---SRNQCLCPPD 134
           CQ G      G+  H    L   TG      +   P   C NGG C    +   C CPP+
Sbjct: 227 CQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPE 286

Query: 135 FTGRFC 140
           +TG++C
Sbjct: 287 WTGQYC 292



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 8/47 (17%)

Query: 104 TGSGFRVVVCPL---PCMNGGQCSSRN-----QCLCPPDFTGRFCQV 142
           TG+   VV+ P    PC NGG+C          C+CP  + G+ C+V
Sbjct: 822 TGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 11/72 (15%)

Query: 84   CQQGSNMTLIGENGHSTDTLTGSGFRVVVCP--------LPCMNGGQCSSRNQ---CLCP 132
            C+ G    +             +GF    C         L C+NGG C S  +   CLC 
Sbjct: 1316 CKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCL 1375

Query: 133  PDFTGRFCQVPA 144
              FTG  CQ PA
Sbjct: 1376 GPFTGPECQFPA 1387



 Score = 34.7 bits (78), Expect = 0.59
 Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 4/32 (12%)

Query: 114 PLPCMNGGQCSSR----NQCLCPPDFTGRFCQ 141
           P PC NGG C       ++C C P FTG+ C+
Sbjct: 224 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCE 255



 Score = 34.7 bits (78), Expect = 0.59
 Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 33/141 (23%)

Query: 341  CPQGYKRLNSTHCQ-DINEC--------AMPGVCRHGDCLNNPGSYRCVCPP---GHSLG 388
            CP+G +     HC+ ++++C          P    +G C++  G Y C CPP   G    
Sbjct: 1209 CPRGTQ---GVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1265

Query: 389  PSRTQCIADKPEEKSL--CFRLVSPEH-QCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT 445
                +C+++  + +    C + V+  H +C+   T R      C SV    G + + C  
Sbjct: 1266 GDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRR-----CESVIN--GCKGKPCKN 1318

Query: 446  DGTAA--------FKEICPAG 458
             GT A        F   CPAG
Sbjct: 1319 GGTCAVASNTARGFICKCPAG 1339



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 13/30 (43%), Positives = 18/30 (60%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCS----SRNQCLCPPDFTGRFCQ 141
           PC NGG C     +  +C CPP ++G+ CQ
Sbjct: 110 PCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ 139



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 20/53 (37%), Positives = 23/53 (43%), Gaps = 12/53 (22%)

Query: 116  PCMNGGQCSSRNQ------CLCPPDFTGRFCQVPAGGAG------GGTGGSGP 156
            PC NGG C+  +       C CP  F G  C+  A   G      GGT  SGP
Sbjct: 1315 PCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGP 1367



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PC++ G+C  +    QC CP  FTG  CQ
Sbjct: 498 PCLHNGRCLDKINEFQCECPTGFTGHLCQ 526



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 22/89 (24%), Positives = 31/89 (34%), Gaps = 8/89 (8%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQ---CLC 131
           C  G C+D     + +   G  GH  +T             PC +GG C  R+    C C
Sbjct: 575 CHYGSCKDGVATFTCLCRPGYTGHHCETNINE-----CSSQPCRHGGTCQDRDNAYLCFC 629

Query: 132 PPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160
               TG  C++           SG  L +
Sbjct: 630 LKGTTGPNCEINLDDCASSPCDSGTCLDK 658



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 22/86 (25%), Positives = 39/86 (45%), Gaps = 8/86 (9%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPG-HSLGPSR--TQCIA 396
            C  GY     ++C+D+ +   P  C++G  C +  G Y C C  G H +  S    +C++
Sbjct: 1133 CQAGY---TGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLS 1189

Query: 397  DKPEEKSLCFRLVSPEHQCQHPLTTR 422
               +    C  L +  ++C  P  T+
Sbjct: 1190 HPCQNGGTCLDLPN-TYKCSCPRGTQ 1214



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/78 (30%), Positives = 31/78 (39%), Gaps = 24/78 (30%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQC--- 123
           C+ G CRDS            NG+  D     G+    C +        PC+NGG C   
Sbjct: 725 CVHGACRDSL-----------NGYKCDC--DPGWSGTNCDINNNECESNPCVNGGTCKDM 771

Query: 124 SSRNQCLCPPDFTGRFCQ 141
           +S   C C   F+G  CQ
Sbjct: 772 TSGYVCTCREGFSGPNCQ 789



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 14/31 (45%), Positives = 17/31 (54%), Gaps = 3/31 (9%)

Query: 114 PLPCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           P PC NGG C+   +   C C P F G FC+
Sbjct: 913 PNPCHNGGSCTDGINTAFCDCLPGFRGTFCE 943



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVC 381
           C +G+   N   CQ +INECA       G C+++   Y+C C
Sbjct: 779 CREGFSGPN---CQTNINECASNPCLNQGTCIDDVAGYKCNC 817



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 117 CMNGGQCSSRN---QCLCPPDFTGRFCQVP 143
           C+NGG+C + N    C+C   F G  CQ P
Sbjct: 31  CLNGGKCEAANGTEACVCGGAFVGPRCQDP 60



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 12/29 (41%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116  PCMNGGQCSS---RNQCLCPPDFTGRFCQ 141
            PC++GG C       +C CP  +TG  CQ
Sbjct: 1029 PCLHGGTCQDGCGSYRCTCPQGYTGPNCQ 1057


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  204 bits (519), Expect = 4e-52
 Identities = 260/983 (26%), Positives = 358/983 (36%), Gaps = 205/983 (20%)

Query: 338  GADC---PQGYK-----RLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388
            GA C   P GY+         T C +++++C+ P  C HG C++   S+ C C PG+   
Sbjct: 519  GAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS-PDPCHHGRCVDGIASFSCACAPGY--- 574

Query: 389  PSRTQCIADKPEEKSLCFRLVSPEHQCQH--PLTTRLTRQLCCCSVGKAWGARCQ----R 442
             + T+C +   E +S           C+H       + + LC C  G   G  C+     
Sbjct: 575  -TGTRCESQVDECRS---------QPCRHGGKCLDLVDKYLCRCPSGTT-GVNCEVNIDD 623

Query: 443  CPT---------DGTAAFKEICPAGKGYHILT-----------SHQTLTIQGESDFSLFL 482
            C +         DG   +  +C  G    +                   + GE+ F   L
Sbjct: 624  CASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC-L 682

Query: 483  HPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPEL 542
             P G   P  LP S   A  P       G+  D+P                         
Sbjct: 683  CPPGSLPPLCLPPSHPCAHEP----CSHGICYDAPGGF--------------------RC 718

Query: 543  ISRPSPPTMRWFLPDLPPS--RSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH 600
            +  P      W  P    S  R A E  P        CR        G C      + C 
Sbjct: 719  VCEPG-----WSGPRCSQSLARDACESQP--------CRAG------GTCSSDGMGFHCT 759

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN-CHCNRGYRLHVGAGGRSCV 659
            C PG     Q R C  ++ C   PC  G G C +  G    C C +G++     G R   
Sbjct: 760  CPPGV----QGRQCELLSPCTPNPCEHG-GRCESAPGQLPVCSCPQGWQ-----GPRCQQ 809

Query: 660  DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPD-GKC 718
            D++ECA P  CG  G C N  G + C C+ GY    + P   +DI++C DP+ C + G C
Sbjct: 810  DVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDC-DPNPCLNGGSC 864

Query: 719  ENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778
            ++  GSF C +C PG+   G    RDV+EC   +PC PG C +   SF CTC  GY    
Sbjct: 865  QDGVGSFSC-SCLPGF--AGPRCARDVDECL-SNPCGPGTCTDHVASFTCTCPPGYG--- 917

Query: 779  DGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFPAAC 836
             G  C  D+ +C      + G C +   SF C C  GY      +HC+ + D C      
Sbjct: 918  -GFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHCQHEADPCLSRPCL 972

Query: 837  IGGDCINTNGSYRCLCPQGHRLVGGRKCQD-IDECSQDPSLCLPHGACKNLQGSYVCVCD 895
             GG C   +  +RC C +      G +CQ  +D CS+ P  C   G C  +Q    C+C 
Sbjct: 973  HGGVCSAAHPGFRCTCLESFT---GPQCQTLVDWCSRQP--CQNGGRC--VQTGAYCLCP 1025

Query: 896  EGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDS--VLATNVTQQECCCSLGAGWGDH 953
             G++       C+    P  +    +       C +        +   C C  G   G H
Sbjct: 1026 PGWSGRL----CDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGR-TGSH 1080

Query: 954  CEIYPCPVYSSAEFHS----------LCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE 1003
            CE    P  +    H           +C    GY  DN           D+DEC    S+
Sbjct: 1081 CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDN--------CEDDVDEC---ASQ 1129

Query: 1004 ICKE-GKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-----LDES-NC-RNGVCENTR 1055
             C+  G C++    Y C C  G    G L E ++ D+C     LD    C  NG C +  
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPGTL--GVLCE-INEDDCGPGPPLDSGPRCLHNGTCVDLV 1186

Query: 1056 GGYRCACTPPAEYSPAQ---RQCLSPEEMERAPERRDVCWSQRGE-DGMCAGPLAGP-AL 1110
            GG+RC C P       +    +C S      A   RD      G    +C    +GP   
Sbjct: 1187 GGFRCTCPPGYTGLRCEADINECRS--GACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244

Query: 1111 TFDDCCCRQGRGWGAQCRPCPPRGAG----SHCPTSQSESNSFWDTSPLLLGKPPRDEDS 1166
            T    C  Q    G QCRP P  G G     HC      +  FW          PR E  
Sbjct: 1245 TVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHC------AQPFWG---------PRCERV 1289

Query: 1167 SEEDSDECRCVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLC---K 1222
            +     E +C  G  C   P G  C CP G    + R+           +     C    
Sbjct: 1290 A-RSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG 1348

Query: 1223 SERCVNTSGSFRCVCKAGFARSR 1245
            S R    +  FRC C  G+   R
Sbjct: 1349 SCRPAPLAPFFRCACAQGWTGPR 1371



 Score =  189 bits (480), Expect = 1e-47
 Identities = 201/771 (26%), Positives = 283/771 (36%), Gaps = 156/771 (20%)

Query: 560  PSRSAVEIAPTQVTETDECRLNQNICGHGEC----------VPGPPDYSCHCNPGYRSHP 609
            PSR A  + P      + C+L ++ C  G C          V G   +SC C  G+R   
Sbjct: 59   PSREAACLCPPGWVG-ERCQL-EDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPD 116

Query: 610  QHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPH 668
                C   + C + PC  G    +   G + C C  GY+      GRSC  D++EC    
Sbjct: 117  ----CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ------GRSCRSDVDECRVGE 166

Query: 669  LCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG--SFK 726
             C  GG C+N PG ++C C  GY       P+CE+      PS C +G    + G  ++ 
Sbjct: 167  PCRHGGTCLNTPGSFRCQCPAGYT-----GPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221

Query: 727  CIACQPGYRSQGGGACR-DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL- 784
            C AC PG+  Q    C  +V++C      + G C +   ++ C C     P   G+ C  
Sbjct: 222  C-ACLPGFEGQN---CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP----PEWTGQFCTE 273

Query: 785  DVDECEAG-DVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI 842
            DVDEC+   + C NG  C NT G   C C++G+      S  ++ID+C       G  C 
Sbjct: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW---TGESCSQNIDDCATAVCFHGATCH 330

Query: 843  NTNGSYRCLCPQGHR-------------------------------------LVGGRKCQ 865
            +   S+ C CP G                                         GG   Q
Sbjct: 331  DRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT-PTQDQHGCEEVEQPHHKKECYLNFD 924
            D+DECS   + C   G C N QGS++C C  G+T P  +    E +  P   +   L+  
Sbjct: 391  DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450

Query: 925  DTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE-----FHSLCPDGKGYTQ 979
                C  +     T   C   +     D C+  PC      +     F   CP G     
Sbjct: 451  GQFTC--ICMAGFTGTYCEVDI-----DECQSSPCVNGGVCKDRVNGFSCTCPSGFS--- 500

Query: 980  DNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVD 1038
                   G     D+DEC    S  C+ G KCV+   GYEC C +GF  +G L +  +VD
Sbjct: 501  -------GSTCQLDVDEC---ASTPCRNGAKCVDQPDGYECRCAEGF--EGTLCD-RNVD 547

Query: 1039 ECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGED 1098
            +C  +  C +G C +    + CAC P    +  + Q    +E    P R         + 
Sbjct: 548  DCSPDP-CHHGRCVDGIASFSCACAPGYTGTRCESQV---DECRSQPCRHGGKCLDLVDK 603

Query: 1099 GMCAGPLAGPA----LTFDDCC--------CRQG-RGWGAQCRP---------------C 1130
             +C  P         +  DDC         CR G   +   C+P                
Sbjct: 604  YLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECAS 663

Query: 1131 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVC 1190
             P G G  C   ++          L    PP     S   + E  C  G C   PGG  C
Sbjct: 664  SPCGEGGSCVDGENGFRCLCPPGSL----PPLCLPPSHPCAHE-PCSHGICYDAPGGFRC 718

Query: 1191 EC-PGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1240
             C PG      S++   D  E +     G       C +    F C C  G
Sbjct: 719  VCEPGWSGPRCSQSLARDACESQPCRAGG------TCSSDGMGFHCTCPPG 763



 Score =  161 bits (408), Expect = 3e-39
 Identities = 222/921 (24%), Positives = 305/921 (33%), Gaps = 205/921 (22%)

Query: 355  DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414
            +INECA       G C++    +RC+CPPG SL P              LC   + P H 
Sbjct: 657  EINECASSPCGEGGSCVDGENGFRCLCPPG-SLPP--------------LC---LPPSHP 698

Query: 415  CQH-PLTTRLTRQL-----CCCSVGKAWGARCQR------CPTDGTAAFKEICPAGKGYH 462
            C H P +  +         C C  G + G RC +      C +    A       G G+H
Sbjct: 699  CAHEPCSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARDACESQPCRAGGTCSSDGMGFH 757

Query: 463  ILTSHQTLTIQGESDFSLFLHPDGPPKPQ---QLPESPSQAPPPEDTEEERGVTTDSPVS 519
                      Q E      L P  P   +   +   +P Q P     +  +G      V 
Sbjct: 758  CTCPPGVQGRQCE-----LLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD 812

Query: 520  EERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAV----EIAPTQVTET 575
            E                       + P+P        +L  S S         P+   + 
Sbjct: 813  E----------------------CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            ++C  N  + G G C  G   +SC C PG+      R   DV+EC + PCGP  G C + 
Sbjct: 851  NDCDPNPCLNG-GSCQDGVGSFSCSCLPGFAG---PRCARDVDECLSNPCGP--GTCTDH 904

Query: 636  GGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
              S+ C C  GY      GG  C  DL +C+ P  C +GG C++    + C C PGY   
Sbjct: 905  VASFTCTCPPGY------GGFHCEQDLPDCS-PSSCFNGGTCVDGVNSFSCLCRPGY--- 954

Query: 695  ASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA--------CQPGYRSQGGGACRDVN 746
             +      + D C        G C      F+C          CQ          C++  
Sbjct: 955  -TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGG 1013

Query: 747  ECAEGSP---CSPGWCENLPGSFRCTCAQG-------------------------YAPAP 778
             C +      C PGW   L       C +                          Y   P
Sbjct: 1014 RCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCP 1073

Query: 779  DGRS---C-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFP 833
            +GR+   C  +VD C A      G C    G + C+CL GY    +  +CE D+DEC   
Sbjct: 1074 EGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQ 1129

Query: 834  AACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSL-----CLPHGACKNLQ 887
                GG CI+    Y C CP G     G  C+ + D+C   P L     CL +G C +L 
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPG---TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV 1186

Query: 888  GSYVCVCDEGFTPTQDQHGCEEVE----QPHHKKE------------CYLNFDDTVFCDS 931
            G + C C  G+T  + +    E         H ++            C+  F     C +
Sbjct: 1187 GGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGP-RCQT 1245

Query: 932  VLATNVTQQ-----ECCCSLGAG-------------WGDHCEIYPCPVYSSAEFHSLCPD 973
            VL+   +Q      +C  S G G             WG  CE       S  E    CP 
Sbjct: 1246 VLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV---ARSCRELQ--CPV 1300

Query: 974  GKGYTQDNNIVNYGIPAHRDIDECMLF-------GSEICKEGKCVN--------TQPGYE 1018
            G    Q         P       C  F        +  C    C++          P + 
Sbjct: 1301 GVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR 1360

Query: 1019 CYCKQGFYYDGNLLEC-VDVDECLDESNCRNGVCENTRGGYRC--ACTPPAEYSPAQRQC 1075
            C C QG  + G   E      E  +E  C    C+  RG  RC   C  P          
Sbjct: 1361 CACAQG--WTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCS 1418

Query: 1076 LSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP-----C 1130
            LS  +  R  E    CW +   +  C    + PA  +D+  C  G G    C P     C
Sbjct: 1419 LSVGDPWRQCEALQ-CW-RLFNNSRCDPACSSPACLYDNFDCHAG-GRERTCNPVYEKYC 1475

Query: 1131 PPRGAGSHCPTSQSESNSFWD 1151
                A   C    +     WD
Sbjct: 1476 ADHFADGRCDQGCNTEECGWD 1496



 Score =  159 bits (401), Expect = 2e-38
 Identities = 178/655 (27%), Positives = 244/655 (37%), Gaps = 174/655 (26%)

Query: 652  GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYK-CNCYPGYRLKASRPPVCEDIDECRDP 710
            GA    C+D + CA      +GG C   P     C C PG+  +      C+  D C   
Sbjct: 37   GAAAPPCLDGSPCA------NGGRCTQLPSREAACLCPPGWVGER-----CQLEDPCHSG 85

Query: 711  SSCPDGKCENK----PGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGW-CENLP-G 764
                 G C++        F C  C  G+R   G  C   + C   SPC+ G  C   P G
Sbjct: 86   PCAGRGVCQSSVVAGTARFSC-RCPRGFR---GPDCSLPDPCLS-SPCAHGARCSVGPDG 140

Query: 765  SFRCTCAQGYAPAPDGRSCL-DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGY------- 815
             F C+C  GY     GRSC  DVDEC  G+ C +G  C NTPGSF+CQC +GY       
Sbjct: 141  RFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN 196

Query: 816  --------------------HLSRDRS--------HCE-DIDECDFPAACIGGDCINTNG 846
                                 L+ D +        +CE ++D+C       GG C++   
Sbjct: 197  PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 256

Query: 847  SYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQH 905
            +Y C CP       G+ C +D+DEC   P+ C   G C N  G + CVC  G+T      
Sbjct: 257  TYNCQCPPEWT---GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTG----- 308

Query: 906  GCEEVEQPHHKKECYLNFDDTV----FCDSVLATNVTQQECCCSLG-----AGWGDHCEI 956
                       + C  N DD      F  +     V    C C +G         D C  
Sbjct: 309  -----------ESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS 357

Query: 957  YPCPVYSSAEFH-----SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE-GKC 1010
             PC   +  + +     ++C    G+T        G    +D+DEC + G+  C+  G+C
Sbjct: 358  NPCHEDAICDTNPVNGRAICTCPPGFT--------GGACDQDVDECSI-GANPCEHLGRC 408

Query: 1011 VNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSP 1070
            VNTQ  + C C +G  Y G   E  DV+ECL      +G C N                 
Sbjct: 409  VNTQGSFLCQCGRG--YTGPRCE-TDVNECL------SGPCRN----------------- 442

Query: 1071 AQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC 1130
             Q  CL     +R  +   +C +  G  G          +  D+C          Q  PC
Sbjct: 443  -QATCL-----DRIGQFTCICMA--GFTGTYC------EVDIDEC----------QSSPC 478

Query: 1131 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVC 1190
               G        +   N F  T P          D  E  S  CR    +CV +P G  C
Sbjct: 479  VNGGV------CKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRN-GAKCVDQPDGYEC 531

Query: 1191 ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSR 1245
             C  GF+         ++D+C         C   RCV+   SF C C  G+  +R
Sbjct: 532  RCAEGFEGTLCDR---NVDDCSPDP-----CHHGRCVDGIASFSCACAPGYTGTR 578



 Score =  136 bits (343), Expect = 1e-31
 Identities = 161/674 (23%), Positives = 222/674 (32%), Gaps = 229/674 (33%)

Query: 730  CQPGYRSQGGGACRDVNECAEGSPCSPGW----------CENLP---------------G 764
            C  G     GG C  +        C PGW          C + P                
Sbjct: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTA 102

Query: 765  SFRCTCAQGY----------------------------------APAPDGRSC-LDVDEC 789
             F C C +G+                                   P   GRSC  DVDEC
Sbjct: 103  RFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDEC 162

Query: 790  EAGDVC-DNGICSNTPGSFQCQCLSGY---------------------------HLSRD- 820
              G+ C   G C NTPGSF+CQC +GY                            L+ D 
Sbjct: 163  RVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDC 222

Query: 821  -------RSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQ 872
                     +CE ++D+C       GG C++   +Y C CP      G    +D+DEC  
Sbjct: 223  ACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP--EWTGQFCTEDVDECQL 280

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDD----TVF 928
             P+ C   G C N  G + CVC  G+T                 + C  N DD      F
Sbjct: 281  QPNACHNGGTCFNTLGGHSCVCVNGWT----------------GESCSQNIDDCATAVCF 324

Query: 929  CDSVLATNVTQQECCCSLG-----AGWGDHCEIYPCPVYSSAEFH-----SLCPDGKGYT 978
              +     V    C C +G         D C   PC   +  + +     ++C    G+T
Sbjct: 325  HGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFT 384

Query: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQPGYECYCKQGF---YYDGNLLEC 1034
                    G    +D+DEC + G+  C+  G+CVNTQ  + C C +G+     + ++ EC
Sbjct: 385  --------GGACDQDVDECSI-GANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNEC 435

Query: 1035 --------------------------------VDVDECLDESNCRNGVCENTRGGYRCAC 1062
                                            VD+DEC        GVC++   G+ C C
Sbjct: 436  LSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTC 495

Query: 1063 TPPAEYSPAQRQCLSPEEMERAPERRDV-CWSQ-RGEDGMCAGPLAGPAL--TFDDCC-- 1116
              P+ +S +  Q L  +E    P R    C  Q  G +  CA    G       DDC   
Sbjct: 496  --PSGFSGSTCQ-LDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPD 552

Query: 1117 -CRQGR---GWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSD 1172
             C  GR   G  +    C P   G+ C                            E   D
Sbjct: 553  PCHHGRCVDGIASFSCACAPGYTGTRC----------------------------ESQVD 584

Query: 1173 ECRCV----SGRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCKSERCV 1227
            ECR       G+C+      +C CP G     +   C V+ID+C         C    C 
Sbjct: 585  ECRSQPCRHGGKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCASNP-----CTFGVCR 635

Query: 1228 NTSGSFRCVCKAGF 1241
            +    + CVC+ GF
Sbjct: 636  DGINRYDCVCQPGF 649



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 40/121 (33%), Positives = 55/121 (45%), Gaps = 24/121 (19%)

Query: 286 KQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQ-LQYTGVQKPGP---------VRG 335
           + PC S P  G   +  C  S+     +  C +CP+  +      P P          R 
Sbjct: 79  EDPCHSGPCAG---RGVCQSSVVAGTARFSC-RCPRGFRGPDCSLPDPCLSSPCAHGARC 134

Query: 336 EVGAD------CPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCPPGHSLG 388
            VG D      CP GY+  +     D++EC +   CRHG  CLN PGS+RC CP G++ G
Sbjct: 135 SVGPDGRFLCSCPPGYQGRSCR--SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT-G 191

Query: 389 P 389
           P
Sbjct: 192 P 192



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 32/80 (40%), Positives = 40/80 (50%), Gaps = 10/80 (12%)

Query: 1176 CVSG-RCVPRPGGA-VCECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGS 1232
            C  G RC   P G  +C CP G+Q  + R+   D+DECR     G  C+    C+NT GS
Sbjct: 128  CAHGARCSVGPDGRFLCSCPPGYQGRSCRS---DVDECRV----GEPCRHGGTCLNTPGS 180

Query: 1233 FRCVCKAGFARSRPHGACVP 1252
            FRC C AG+         VP
Sbjct: 181  FRCQCPAGYTGPLCENPAVP 200



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/354 (24%), Positives = 111/354 (31%), Gaps = 92/354 (25%)

Query: 116 PCMNGGQC----SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPP 171
           PC NGG+C    S    CLCPP + G  CQ+      G   G G   S   A  T     
Sbjct: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVA-GTARFSC 106

Query: 172 LAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGP-GQISAEVQAPPPVVNV 230
             P G                  P P    P  H A    +GP G+              
Sbjct: 107 RCPRGFRGPD----------CSLPDPCLSSPCAHGA-RCSVGPDGRFLCSC--------- 146

Query: 231 RVHHPPEASVQVHRIESSNAESAAPSQH---LLPHPKPSHPRPPTQKPLGRCFQDTLPKQ 287
               PP    +  R +        P +H    L  P     + P       C     P  
Sbjct: 147 ----PPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN---PAV 199

Query: 288 PCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPG--PVRGEVGADCPQGY 345
           PC  +P          C + GT      C +   L Y     PG      EV  D   G+
Sbjct: 200 PCAPSP----------CRNGGT------CRQSGDLTYDCACLPGFEGQNCEVNVDDCPGH 243

Query: 346 KRLNSTHC---------------------QDINECAM-PGVCRH-GDCLNNPGSYRCVCP 382
           + LN   C                     +D++EC + P  C + G C N  G + CVC 
Sbjct: 244 RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCV 303

Query: 383 PGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT--TRLTRQLCCCSVGK 434
            G + G S +Q I D       C   V     C H  T   R+    C C +GK
Sbjct: 304 NGWT-GESCSQNIDD-------CATAV-----CFHGATCHDRVASFYCACPMGK 344



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/148 (26%), Positives = 53/148 (35%), Gaps = 21/148 (14%)

Query: 328  QKPGPVRGEVGA---DCPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPP 383
            Q  G  RG +G    +C  GY   N  +C+D ++ECA       G C++    Y C CPP
Sbjct: 1094 QHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPP 1150

Query: 384  G----------HSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHP---LTTRLTRQLCCC 430
            G             GP        +      C  LV    +C  P      R    +  C
Sbjct: 1151 GTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRCEADINEC 1209

Query: 431  SVGKAWGARCQRCPTDGTAAFKEICPAG 458
              G    A  + C  D    F+ +C AG
Sbjct: 1210 RSGACHAAHTRDCLQDPGGGFRCLCHAG 1237



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 11/74 (14%)

Query: 73   RTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVV---CPLPCMNGGQCSSRNQ- 128
            R CL G    +   G   T +       ++ TG   + +V      PC NGG+C      
Sbjct: 969  RPCLHGGVCSAAHPGFRCTCL-------ESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021

Query: 129  CLCPPDFTGRFCQV 142
            CLCPP ++GR C +
Sbjct: 1022 CLCPPGWSGRLCDI 1035



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 17/77 (22%)

Query: 75  CLKGQCRD--SCQQGSNMT-----LIGENGHSTDTLTGSGFRVVVCP-LPCMNGGQCS-- 124
           C    CR+  +C+Q  ++T     L G  G + +        V  CP   C+NGG C   
Sbjct: 201 CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV------NVDDCPGHRCLNGGTCVDG 254

Query: 125 -SRNQCLCPPDFTGRFC 140
            +   C CPP++TG+FC
Sbjct: 255 VNTYNCQCPPEWTGQFC 271



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 18/79 (22%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQCSSR 126
           CL G CR+        T +   G  T  +  +GF    C +        PC+NGG C  R
Sbjct: 435 CLSGPCRNQA------TCLDRIGQFT-CICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR 487

Query: 127 ---NQCLCPPDFTGRFCQV 142
                C CP  F+G  CQ+
Sbjct: 488 VNGFSCTCPSGFSGSTCQL 506



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 53/186 (28%), Positives = 66/186 (35%), Gaps = 48/186 (25%)

Query: 28  LLLLLLLLGLGGRVEGGPAGERGAGGGGAL---ARERFKVVFAPVICKRTCLKGQCR--D 82
           L LLLLL G G        G   A GG      +RE      A  +C    +  +C+  D
Sbjct: 27  LPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSRE------AACLCPPGWVGERCQLED 80

Query: 83  SCQQGSNMTLIGENGHSTDTLTGS---------GFRVVVCPLP-------CMNGGQCS-- 124
            C  G      G     +  + G+         GFR   C LP       C +G +CS  
Sbjct: 81  PCHSGP---CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVG 137

Query: 125 --SRNQCLCPPDFTGRF-------CQVPAGGAGGGTGGSGPGLSR-------TGALSTGA 168
              R  C CPP + GR        C+V      GGT  + PG  R       TG L    
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197

Query: 169 LPPLAP 174
             P AP
Sbjct: 198 AVPCAP 203



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 33/106 (31%), Positives = 44/106 (41%), Gaps = 25/106 (23%)

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
           CP G+    ST   D++ECA    CR+G  C++ P  Y C C  G               
Sbjct: 495 CPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGF-------------- 537

Query: 400 EEKSLCFRLV---SPEHQCQH-PLTTRLTRQLCCCSVGKAWGARCQ 441
            E +LC R V   SP+  C H      +    C C+ G   G RC+
Sbjct: 538 -EGTLCDRNVDDCSPD-PCHHGRCVDGIASFSCACAPGYT-GTRCE 580



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 75/299 (25%), Positives = 90/299 (30%), Gaps = 70/299 (23%)

Query: 125 SRNQCLCPPDFTGRFCQV--------PAGGAGGGTGGSGPG--LSRTGALSTGALPPLAP 174
           +R  C+C P FTG  C V        P G  G    G      L   G+L    LPP  P
Sbjct: 639 NRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHP 698

Query: 175 EGDSVASKHAIYAVQVIADPPG-------PG-EGPPAQHAAFLVPLGPGQISAEVQAPPP 226
                 S    Y      D PG       PG  GP    +            A       
Sbjct: 699 CAHEPCSHGICY------DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD 752

Query: 227 VVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLG----RCFQD 282
            +      PP   VQ  + E  +  +  P +H           P    P G    RC QD
Sbjct: 753 GMGFHCTCPP--GVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD 810

Query: 283 TLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP 342
                 C + P P        CG  G          C  L            G     C 
Sbjct: 811 V---DEC-AGPAP--------CGPHGI---------CTNLA-----------GSFSCTCH 838

Query: 343 QGYKRLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
            GY       C QDIN+C        G C +  GS+ C C PG + GP   +C  D  E
Sbjct: 839 GGY---TGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA-GP---RCARDVDE 890



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 29/91 (31%), Positives = 34/91 (37%), Gaps = 11/91 (12%)

Query: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQ---CLC 131
           C  G C D+         + E G S    + S  R      PC  GG CSS      C C
Sbjct: 704 CSHGICYDA---PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC 760

Query: 132 PPDFTGRFCQV-----PAGGAGGGTGGSGPG 157
           PP   GR C++     P     GG   S PG
Sbjct: 761 PPGVQGRQCELLSPCTPNPCEHGGRCESAPG 791



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 37/130 (28%), Positives = 48/130 (36%), Gaps = 28/130 (21%)

Query: 149  GGTGGSGPGLSRTGA--LSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHA 206
            GG G +G G    G   LS G L P+A   D        +A      PPGP         
Sbjct: 2141 GGPGRAGLGRQPPGGCVLSLGLLNPVAVPLD--------WARLPPPAPPGP--------- 2183

Query: 207  AFLVPLGPGQ--------ISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQH 258
            +FL+PL PG         +S + + PPP + V  H     +   H           PS+H
Sbjct: 2184 SFLLPLAPGPQLLNPGTPVSPQ-ERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEH 2242

Query: 259  LLPHPKPSHP 268
                P P  P
Sbjct: 2243 PYLTPSPESP 2252



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 10/72 (13%)

Query: 334 RGEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRH-GDCLNNPGSYRCVCPPGHSLGPSR 391
           +G     C +GY       C+ D+NEC + G CR+   CL+  G + C+C  G     + 
Sbjct: 412 QGSFLCQCGRGY---TGPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGF----TG 463

Query: 392 TQCIADKPEEKS 403
           T C  D  E +S
Sbjct: 464 TYCEVDIDECQS 475



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 15/37 (40%), Positives = 17/37 (45%), Gaps = 4/37 (10%)

Query: 110 VVVCPLPCMNGGQCSSRN----QCLCPPDFTGRFCQV 142
           V   P PC NGG C         C C P F G+ C+V
Sbjct: 199 VPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV 235



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 4/51 (7%)

Query: 116  PCMNGGQCS---SRNQCLCPPDFTGRFCQVPAGGAGGGTG-GSGPGLSRTG 162
            PC +GG C    +R  C CPP   G  C++     G G    SGP     G
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNG 1180



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 482  LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
            L+P  P  PQ+ P      P   +     G  +  P +    V   HP  T +P    PE
Sbjct: 2196 LNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPES--PE 2253

Query: 542  LISRPSPPTMRWFLPDLPPSRSA 564
              + PSPP++  +    P   +A
Sbjct: 2254 HWASPSPPSLSDWSESTPSPATA 2276



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 49/199 (24%), Positives = 74/199 (37%), Gaps = 28/199 (14%)

Query: 277 GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--PGPVR 334
           G C QD + +   G+NP   L +  +  GS     G+   +  P+ + T V +   GP R
Sbjct: 386 GACDQD-VDECSIGANPCEHLGRCVNTQGSFLCQCGRG--YTGPRCE-TDVNECLSGPCR 441

Query: 335 ---------GEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
                    G+    C  G+     T+C+ DI+EC        G C +    + C CP G
Sbjct: 442 NQATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498

Query: 385 HSLGPSR---TQCIADKPEEKSLCF-RLVSPEHQCQHPLT-TRLTRQLCCCSVGKAWGAR 439
            S    +    +C +      + C  +    E +C      T   R +  CS       R
Sbjct: 499 FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558

Query: 440 CQRCPTDGTAAFKEICPAG 458
           C     DG A+F   C  G
Sbjct: 559 C----VDGIASFSCACAPG 573



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 114 PLPCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           P  C NGG C    +   CLC P +TG  CQ
Sbjct: 930 PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  202 bits (514), Expect = 2e-51
 Identities = 213/733 (29%), Positives = 281/733 (38%), Gaps = 138/733 (18%)

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC--EAEPCGPGRGICM 633
            D C  N  + G G C+   P   CHC PG+  H   R   DVNEC  +  PC  G   C 
Sbjct: 158  DFCSANPCVNG-GVCLATYPQIQCHCPPGFEGHACER---DVNECFQDPGPCPKGTS-CH 212

Query: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFP----GHYKCNCYP 689
            NT GS+ C C       VG  G  C        P  C +GG C   P      + C C P
Sbjct: 213  NTLGSFQCLC------PVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266

Query: 690  GYRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNEC 748
            G+       P CE + D C        G C++   ++ C+  +      G     DV+EC
Sbjct: 267  GF-----IGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETW---TGWDCSEDVDEC 318

Query: 749  AEGSP--C-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGICSNTP 804
                P  C + G C+N  GSF C C  G+     G SC + +D+C A        C +  
Sbjct: 319  ETQGPPHCRNGGTCQNSAGSFHCVCVSGWG----GTSCEENLDDCIAATCAPGSTCIDRV 374

Query: 805  GSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN---GSYRCLCPQGHRLVGG 861
            GSF C C  G    R    C   D C     C G    +TN   GS  CLC  G+    G
Sbjct: 375  GSFSCLCPPG----RTGLLCHLEDMC-LSQPCHGDAQCSTNPLTGSTLCLCQPGY---SG 426

Query: 862  RKC-QDIDEC---SQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ---DQHGCEEVEQPH 914
              C QD+DEC    Q PS C   G+C N  GS+ C+C  G+T ++   D + C  + QP 
Sbjct: 427  PTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC--LSQPC 484

Query: 915  HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEI-----YPCPVYSSAEFHS 969
            H             C  +LAT      C C  G   G  CE+        P  + A+ H 
Sbjct: 485  HPGST---------CLDLLAT----FHCLCPPGLE-GQLCEVETNECASAPCLNHADCHD 530

Query: 970  L-----CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPG-YECYCKQ 1023
            L     C    G++        G     DIDEC    S  C  G     QPG + C C  
Sbjct: 531  LLNGFQCICLPGFS--------GTRCEEDIDECR---SSPCANGGQCQDQPGAFHCKCLP 579

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMER 1083
            GF  +G   +  +VDECL +       C +  G + C C  P+ ++   + C  P     
Sbjct: 580  GF--EGPRCQ-TEVDECLSDPCPVGASCLDLPGAFFCLC--PSGFT--GQLCEVPLCAPN 632

Query: 1084 APERRDVCWSQRGE-DGMCAGPLAGPALTFDDCCCRQGR----------GW-GAQCR--- 1128
              + + +C  Q+ + + +C     G A   D+C C  G           GW G +C    
Sbjct: 633  LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAEL 692

Query: 1129 ------PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCV 1182
                  PC      +H  T   + + +  T P     P   E+ +   S  C    G C 
Sbjct: 693  GGCISAPC------AHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPC-LNGGSCN 745

Query: 1183 PRPGGAVCECP---GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKA 1239
            P PGG  C CP    G Q   S   CV                   CVN  G+F C+C  
Sbjct: 746  PSPGGYYCTCPPSHTGPQCQTSTDYCVSAP----------CFNGGTCVNRPGTFSCLCAM 795

Query: 1240 GFARSRPHGACVP 1252
            GF   R  G   P
Sbjct: 796  GFQGPRCEGKLRP 808



 Score =  193 bits (491), Expect = 8e-49
 Identities = 199/734 (27%), Positives = 277/734 (37%), Gaps = 119/734 (16%)

Query: 578  CRLNQNICGHGECVPGPP------DYSCHCNPGYRSHPQHRYCVDVNECEAEPC-GPGRG 630
            C  N + C    C PG         +SC C PG         C   + C ++PC G  + 
Sbjct: 352  CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTG----LLCHLEDMCLSQPCHGDAQC 407

Query: 631  ICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAK----PHLCGDGGFCINFPGHYKC 685
                  GS  C C  GY       G +C  DL+EC      P  C  GG C+N PG + C
Sbjct: 408  STNPLTGSTLCLCQPGY------SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461

Query: 686  NCYPGYRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR- 743
             C PGY    SR   CE D +EC      P   C +   +F C+ C PG   Q    C  
Sbjct: 462  LCPPGYT--GSR---CEADHNECLSQPCHPGSTCLDLLATFHCL-CPPGLEGQ---LCEV 512

Query: 744  DVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL-DVDECEAGDVCDNGICSN 802
            + NECA     +   C +L   F+C C  G++    G  C  D+DEC +    + G C +
Sbjct: 513  ETNECASAPCLNHADCHDLLNGFQCICLPGFS----GTRCEEDIDECRSSPCANGGQCQD 568

Query: 803  TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGR 862
             PG+F C+CL G+   R ++   ++DEC      +G  C++  G++ CLCP G     G+
Sbjct: 569  QPGAFHCKCLPGFEGPRCQT---EVDECLSDPCPVGASCLDLPGAFFCLCPSGFT---GQ 622

Query: 863  KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE---GFTPTQDQHGCEEVEQPHHKKEC 919
             C ++  C+  P+LC P   CK+ +    C+C +   G  P +D   C           C
Sbjct: 623  LC-EVPLCA--PNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVC 679

Query: 920  YLNFDDTVFCDSVLATNVTQ--------------QECCCSLGAGWGDHC--EIYPCPVYS 963
             + +     C++ L   ++                 C C  G   G  C  E+  C    
Sbjct: 680  DVGWTGPE-CEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY-TGPTCSEEMTACHSGP 737

Query: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023
                 S  P   GY       + G       D C+   +     G CVN    + C C  
Sbjct: 738  CLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCV--SAPCFNGGTCVNRPGTFSCLCAM 795

Query: 1024 GFYYDGNLLECVDVDECLDESNCRN-GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEME 1082
            GF   G   E      C D S CRN   C+++  G RC C  P  Y+    Q L     +
Sbjct: 796  GF--QGPRCEGKLRPSCAD-SPCRNRATCQDSPQGPRCLC--PTGYTGGSCQTLMDLCAQ 850

Query: 1083 RAPERRDVCWSQRGEDGMC------AGPLAG-PALTFDDCCCRQGRGWGAQCR------- 1128
            +   R   C  Q G    C       GPL   P  +       QG    + C        
Sbjct: 851  KPCPRNSHC-LQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVD 909

Query: 1129 -------PCPPRGAGSHC----------PTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1171
                    CPP   GS C          P     +     +  L    P  D  +  ++ 
Sbjct: 910  SGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL 969

Query: 1172 DECRCV----SGRCVPRPGGAVCECPGGFQLDASRARCV-DIDECRELNQRGLLCKSERC 1226
            D C+       G C P+PGG  C CP GF       RC  D+DEC  L+Q      +  C
Sbjct: 970  DACQSQPCHNHGTCTPKPGGFHCACPPGF----VGLRCEGDVDEC--LDQPCHPTGTAAC 1023

Query: 1227 VNTSGSFRCVCKAG 1240
             + + +F C C  G
Sbjct: 1024 HSLANAFYCQCLPG 1037



 Score =  178 bits (451), Expect = 3e-44
 Identities = 288/1154 (24%), Positives = 387/1154 (33%), Gaps = 298/1154 (25%)

Query: 214  PGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPK--PSHPRPP 271
            PG +    Q P P  N ++                  ++    Q LLP P   PS P P 
Sbjct: 55   PGFLGETCQFPDPCQNAQL-----------------CQNGGSCQALLPAPLGLPSSPSPL 97

Query: 272  TQKPLGRCFQDTLPKQPCGSNPLPGLT------KQED-----CCGSIGT----AWGQSKC 316
            T   L  C              LPG T      K ED      C   G     A G+ +C
Sbjct: 98   TPSFLCTC--------------LPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQC 143

Query: 317  HKCP-----QLQYTGVQKPGP-VRG--------EVGADCPQGYKRLNSTHCQ-DINECAM 361
               P     Q Q        P V G        ++   CP G++      C+ D+NEC  
Sbjct: 144  SCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFE---GHACERDVNECFQ 200

Query: 362  -PGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPL 419
             PG C  G  C N  GS++C+CP G   GP         P       R  S    CQ   
Sbjct: 201  DPGPCPKGTSCHNTLGSFQCLCPVGQE-GPRCELRAGPCPP------RGCSNGGTCQLMP 253

Query: 420  TTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTL---TIQGES 476
                T  LC C  G   G  C+  P +                   SHQ     T Q   
Sbjct: 254  EKDSTFHLCLCPPGFI-GPDCEVNPDN-----------------CVSHQCQNGGTCQDGL 295

Query: 477  DFSLFLHPD---GPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATT 533
            D    L P+   G    + + E  +Q PP        G T  +       V  S    T+
Sbjct: 296  DTYTCLCPETWTGWDCSEDVDECETQGPP----HCRNGGTCQNSAGSFHCVCVSGWGGTS 351

Query: 534  TPARPYPELISRPSPPT-----MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHG 588
                    + +  +P +     +  F    PP R+ +      +   ++  L+Q   G  
Sbjct: 352  CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGL------LCHLEDMCLSQPCHGDA 405

Query: 589  ECVPGPPDYS--CHCNPGYRSHPQHRYCVDVNECEAEPCGPG----RGICMNTGGSYNCH 642
            +C   P   S  C C PGY     H+   D++EC     GP      G C+NT GS+NC 
Sbjct: 406  QCSTNPLTGSTLCLCQPGYSGPTCHQ---DLDECLMAQQGPSPCEHGGSCLNTPGSFNCL 462

Query: 643  CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK-------- 694
            C  GY      G R   D NEC     C  G  C++    + C C PG   +        
Sbjct: 463  CPPGY-----TGSRCEADHNECLS-QPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516

Query: 695  -ASRP---------------PVC----------EDIDECRDPSSCPDGKCENKPGSFKCI 728
             AS P                +C          EDIDECR       G+C+++PG+F C 
Sbjct: 517  CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHC- 575

Query: 729  ACQPGYRSQGGGACRDVNECAEGSPCSPG-WCENLPGSFRCTCAQGY------APAPDGR 781
             C PG+  +G     +V+EC    PC  G  C +LPG+F C C  G+       P     
Sbjct: 576  KCLPGF--EGPRCQTEVDECL-SDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN 632

Query: 782  SCLDVDEC-----EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE----------D 826
             C     C     +A  +C +G     P    C C  G H  R    C+          +
Sbjct: 633  LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHG-HCQRSSCVCDVGWTGPECEAE 691

Query: 827  IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNL 886
            +  C       GG C      Y C CP G+   G    +++  C   P  CL  G+C   
Sbjct: 692  LGGCISAPCAHGGTCYPQPSGYNCTCPTGY--TGPTCSEEMTACHSGP--CLNGGSCNPS 747

Query: 887  QGSYVCVCDEGFTPTQDQHGCEE-VEQPHHKKECYLNFDDTVFC---------------- 929
             G Y C C    T  Q Q   +  V  P       +N   T  C                
Sbjct: 748  PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLR 807

Query: 930  ----DSVLATNVTQQE------CCCSLGAGWG------DHCEIYPCP-----VYSSAEFH 968
                DS      T Q+      C C  G   G      D C   PCP     + +   FH
Sbjct: 808  PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFH 867

Query: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECM-------LFGSEICKE-GKCVNTQPGYECY 1020
             LC   +G+T        G   +  +  C        +  S +C   G CV++ P Y C+
Sbjct: 868  CLCL--QGWT--------GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCH 917

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPE 1079
            C  GF   G+L  C D     +   C+NG  C     GY C C P  +     ++     
Sbjct: 918  CPPGF--QGSL--CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL---- 969

Query: 1080 EMERAPERRDVCWSQRGED-GMCAGPLAGPALTFDDCCCRQG------RGWGAQC--RPC 1130
                     D C SQ   + G C     G       C C  G       G   +C  +PC
Sbjct: 970  ---------DACQSQPCHNHGTCTPKPGG-----FHCACPPGFVGLRCEGDVDECLDQPC 1015

Query: 1131 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCV----SGRCVPRPG 1186
             P G  +      S +N+F+         P       E + D C        G C    G
Sbjct: 1016 HPTGTAA----CHSLANAFYCQC-----LPGHTGQWCEVEIDPCHSQPCFHGGTCEATAG 1066

Query: 1187 ---GAVCECPGGFQ 1197
               G +C CP GF+
Sbjct: 1067 SPLGFICHCPKGFE 1080



 Score =  160 bits (405), Expect = 7e-39
 Identities = 235/984 (23%), Positives = 324/984 (32%), Gaps = 218/984 (22%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGV--CRHGD-CLNNPGSYRCVCPPGH---SLGPSRTQC 394
            CP+ +   + +  +D++EC   G   CR+G  C N+ GS+ CVC  G    S   +   C
Sbjct: 302  CPETWTGWDCS--EDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC 359

Query: 395  IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQL--CCCSVGKAWGARCQRCPTDGTAAFK 452
            IA      S C   V        P  T L   L   C S      A+C   P  G+    
Sbjct: 360  IAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGST--- 416

Query: 453  EICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGV 512
             +C    GY   T HQ        D    L     P P +   S    P   +     G 
Sbjct: 417  -LCLCQPGYSGPTCHQ--------DLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY 467

Query: 513  TTDSPVSEERSV--QQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
            T     ++      Q  HP +T          +    PP +   L ++            
Sbjct: 468  TGSRCEADHNECLSQPCHPGSTCLDLLATFHCLC---PPGLEGQLCEV------------ 512

Query: 571  QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRG 630
               ET+EC  +     H +C      + C C PG+      R   D++EC + PC  G G
Sbjct: 513  ---ETNECA-SAPCLNHADCHDLLNGFQCICLPGFSGT---RCEEDIDECRSSPCANG-G 564

Query: 631  ICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPG 690
             C +  G+++C C  G+      G R   +++EC     C  G  C++ PG + C C  G
Sbjct: 565  QCQDQPGAFHCKCLPGFE-----GPRCQTEVDECLSDP-CPVGASCLDLPGAFFCLCPSG 618

Query: 691  Y-----RLKASRPPVCEDIDECRDPSS-----CPDGKCENKPGSFKCIACQPGYRSQGGG 740
            +      +    P +C+    C+D        CPDG     P    C  C  G+  +   
Sbjct: 619  FTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNC-TCHHGHCQRSSC 677

Query: 741  ACRDVN----ECAE------GSPCSPGW-CENLPGSFRCTCAQGYA-------------- 775
             C DV     EC         +PC+ G  C   P  + CTC  GY               
Sbjct: 678  VC-DVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSG 736

Query: 776  ---------PAPDGRSCL------------DVDECEAGDVCDNGICSNTPGSFQCQCLSG 814
                     P+P G  C               D C +    + G C N PG+F C C  G
Sbjct: 737  PCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMG 796

Query: 815  YH---------------LSRDRSHCEDIDE---CDFPAACIGGDC--------------- 841
            +                  R+R+ C+D  +   C  P    GG C               
Sbjct: 797  FQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRN 856

Query: 842  ---INTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDP--------SLCLPHGACKNLQGS 889
               + T  S+ CLC QG     G  C   +  C +          SLC   G C +   S
Sbjct: 857  SHCLQTGPSFHCLCLQGWT---GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPS 913

Query: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVL---ATNVTQQECCCSL 946
            Y C C  GF  +     C++   P   + C             L   A     Q C   L
Sbjct: 914  YFCHCPPGFQGSL----CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL 969

Query: 947  GAGWGDHCEIYPCPVYSSAE-----FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001
                 D C+  PC  + +       FH  CP G            G+    D+DEC+   
Sbjct: 970  -----DACQSQPCHNHGTCTPKPGGFHCACPPGF----------VGLRCEGDVDECLDQP 1014

Query: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRG---GY 1058
                    C +    + C C  G  + G   E V++D C  +     G CE T G   G+
Sbjct: 1015 CHPTGTAACHSLANAFYCQCLPG--HTGQWCE-VEIDPCHSQPCFHGGTCEATAGSPLGF 1071

Query: 1059 RCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCR 1118
             C C    E          P    RAP     C       G    P   P      C C 
Sbjct: 1072 ICHCPKGFE---------GPTCSHRAPS----CGFHHCHHGGLCLPSPKPGFP-PRCACL 1117

Query: 1119 QGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCV- 1177
             G G      P  P+G G   P   + S S  +T+ L     P    S    S   RC  
Sbjct: 1118 SGYGGPDCLTPPAPKGCGPPSPCLYNGSCS--ETTGL---GGPGFRCSCPHSSPGPRCQK 1172

Query: 1178 --SGRCVPRPGGAVCEC----PGG 1195
              +  C  R G   C+     PGG
Sbjct: 1173 PGAKGCEGRSGDGACDAGCSGPGG 1196



 Score =  154 bits (389), Expect = 5e-37
 Identities = 189/703 (26%), Positives = 259/703 (36%), Gaps = 200/703 (28%)

Query: 623  EPCGPGRGICMNTG-GSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFC----- 676
            EPC  G G C++   G   C C  G+       G +C   + C    LC +GG C     
Sbjct: 33   EPCANG-GTCLSLSLGQGTCQCAPGFL------GETCQFPDPCQNAQLCQNGGSCQALLP 85

Query: 677  --INFPG-------HYKCNCYPGY------------------------RLKASRPPVCED 703
              +  P         + C C PG+                         ++AS  P C  
Sbjct: 86   APLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSC 145

Query: 704  I-----DECRDPSSCPDGKCENKPGSFKCIA--------CQPGYRSQGGGAC-RDVNEC- 748
            +     ++C+    C    C N      C+A        C PG+    G AC RDVNEC 
Sbjct: 146  MPGWTGEQCQLRDFCSANPCVN---GGVCLATYPQIQCHCPPGFE---GHACERDVNECF 199

Query: 749  AEGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSC-LDVDECEAGDVCDNGICSNTP-- 804
             +  PC  G  C N  GSF+C C  G     +G  C L    C      + G C   P  
Sbjct: 200  QDPGPCPKGTSCHNTLGSFQCLCPVG----QEGPRCELRAGPCPPRGCSNGGTCQLMPEK 255

Query: 805  -GSFQ-CQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGG 861
              +F  C C  G+ +  D   CE + D C       GG C +   +Y CLCP+     G 
Sbjct: 256  DSTFHLCLCPPGF-IGPD---CEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPE--TWTGW 309

Query: 862  RKCQDIDEC-SQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECY 920
               +D+DEC +Q P  C   G C+N  GS+ CVC  G+  T     CEE           
Sbjct: 310  DCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGT----SCEE----------- 354

Query: 921  LNFDDTVFC----DSVLATNVTQQECCCSLG-----AGWGDHCEIYPCPVYSSAEFH--- 968
             N DD +       S     V    C C  G         D C   PC   +    +   
Sbjct: 355  -NLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLT 413

Query: 969  --SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLF--GSEICKE-GKCVNTQPGYECYCKQ 1023
              +LC    GY+        G   H+D+DEC++   G   C+  G C+NT   + C C  
Sbjct: 414  GSTLCLCQPGYS--------GPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPP 465

Query: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMER 1083
            G  Y G+  E  D +ECL +       C +    + C C P  E                
Sbjct: 466  G--YTGSRCE-ADHNECLSQPCHPGSTCLDLLATFHCLCPPGLE---------------- 506

Query: 1084 APERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQ 1143
                  +C  +  E   CA   + P L   DC        G QC  C P  +G+ C    
Sbjct: 507  ----GQLCEVETNE---CA---SAPCLNHADCHDLLN---GFQC-ICLPGFSGTRC---- 548

Query: 1144 SESNSFWDTSPLLLGKPPRDEDSSEEDSDECR---CVS-GRCVPRPGGAVCECPGGFQLD 1199
                                    EED DECR   C + G+C  +PG   C+C  GF+  
Sbjct: 549  ------------------------EEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFE-- 582

Query: 1200 ASRARC-VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
                RC  ++DEC  L+    +  S  C++  G+F C+C +GF
Sbjct: 583  --GPRCQTEVDEC--LSDPCPVGAS--CLDLPGAFFCLCPSGF 619



 Score =  107 bits (266), Expect = 9e-23
 Identities = 113/397 (28%), Positives = 146/397 (36%), Gaps = 94/397 (23%)

Query: 588  GECVPGPPDYSCHCNPGYRSHPQHRYCVD-VNECEAEPCGPGRGICMNTGGSYNCHCNRG 646
            G CV   P Y CHC PG+    Q   C D VN CE+ PC  G   CM     Y C C  G
Sbjct: 905  GLCVDSGPSYFCHCPPGF----QGSLCQDHVNPCESRPCQNG-ATCMAQPSGYLCQCAPG 959

Query: 647  YRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY-RLKASRPPVCE-DI 704
            Y       G++C    +  +   C + G C   PG + C C PG+  L+      CE D+
Sbjct: 960  Y------DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLR------CEGDV 1007

Query: 705  DECRDPSSCPDGK--CENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCEN 761
            DEC D    P G   C +   +F C  C PG+  Q    C    +     PC   G CE 
Sbjct: 1008 DECLDQPCHPTGTAACHSLANAFYC-QCLPGHTGQW---CEVEIDPCHSQPCFHGGTCEA 1063

Query: 762  LPGS---FRCTCAQGYAPAPDGRSC------LDVDECEAGDVCDNGICSNTPG-SFQCQC 811
              GS   F C C +G+    +G +C           C  G +C   + S  PG   +C C
Sbjct: 1064 TAGSPLGFICHCPKGF----EGPTCSHRAPSCGFHHCHHGGLC---LPSPKPGFPPRCAC 1116

Query: 812  LSGYHLSRDRSHCEDIDECDFPAACI-GGDCINTNG----SYRCLCPQGH-----RLVGG 861
            LSGY    D         C  P+ C+  G C  T G     +RC CP        +  G 
Sbjct: 1117 LSGYG-GPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGA 1175

Query: 862  RKCQ-------------------DIDECS---QDP-SLCLPHGAC--------------- 883
            + C+                   D  +CS    DP   C  H  C               
Sbjct: 1176 KGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDS 1235

Query: 884  -KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919
             + L   Y C      TP  DQ+  +     H +K C
Sbjct: 1236 EECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGC 1272



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 93/378 (24%), Positives = 119/378 (31%), Gaps = 72/378 (19%)

Query: 116 PCMNGGQCSS---RNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGAL-STGALPP 171
           PC+NGG C +   + QC CPP F G  C+          G    G S    L S   L P
Sbjct: 164 PCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCP 223

Query: 172 LAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVR 231
           +  EG     +            P P  G        L+P            PP  +   
Sbjct: 224 VGQEGPRCELRAG----------PCPPRGCSNGGTCQLMPEKDSTFHL-CLCPPGFIG-- 270

Query: 232 VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS 291
               P+  V      S   ++    Q  L       P   T      C +D      C +
Sbjct: 271 ----PDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTG---WDCSEDV---DECET 320

Query: 292 NPLPGLTKQEDCCGSIG-------TAWGQSKCHKCPQLQYTGVQKPGPV----RGEVGAD 340
              P       C  S G       + WG + C +           PG       G     
Sbjct: 321 QGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCL 380

Query: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGD--CLNNP--GSYRCVCPPGHSLGPSRTQCIA 396
           CP G   L   H +D+    +   C HGD  C  NP  GS  C+C PG+S GP+   C  
Sbjct: 381 CPPGRTGL-LCHLEDM---CLSQPC-HGDAQCSTNPLTGSTLCLCQPGYS-GPT---CHQ 431

Query: 397 DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQL--CCCSVGKAWGARC---------QRCPT 445
           D  E    C         C+H  +   T     C C  G   G+RC         Q C  
Sbjct: 432 DLDE----CLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCEADHNECLSQPCHP 486

Query: 446 DGT-----AAFKEICPAG 458
             T     A F  +CP G
Sbjct: 487 GSTCLDLLATFHCLCPPG 504



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 79/333 (23%), Positives = 109/333 (32%), Gaps = 56/333 (16%)

Query: 75  CLKG-QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCP-LPCMNGGQC-------SS 125
           C KG  C ++      +  +G+ G   +   G       CP   C NGG C       S+
Sbjct: 205 CPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGP------CPPRGCSNGGTCQLMPEKDST 258

Query: 126 RNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAI 185
            + CLCPP F G  C+V           +G G  + G  +   L P    G   +     
Sbjct: 259 FHLCLCPPGFIGPDCEVNPDNCVSHQCQNG-GTCQDGLDTYTCLCPETWTGWDCSEDVDE 317

Query: 186 YAVQVIADPPGPGEGPPAQHAA----FLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQ 241
              Q    PP    G   Q++A     +   G G  S E      +           S  
Sbjct: 318 CETQ---GPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCA----PGSTC 370

Query: 242 VHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQE 301
           + R+ S +         LL H +      P       C  D      C +NPL G T   
Sbjct: 371 IDRVGSFSCLCPPGRTGLLCHLEDMCLSQP-------CHGDA----QCSTNPLTGSTL-- 417

Query: 302 DCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR---------GEVGADCPQGYKRLNSTH 352
            C    G  +    CH+         Q P P           G     CP GY     + 
Sbjct: 418 -CLCQPG--YSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY---TGSR 471

Query: 353 CQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           C+ D NEC          CL+   ++ C+CPPG
Sbjct: 472 CEADHNECLSQPCHPGSTCLDLLATFHCLCPPG 504



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 73/298 (24%), Positives = 96/298 (32%), Gaps = 66/298 (22%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ------VPAGGAGGGTGGSGPG-------LS 159
           PC+NGG C+       C CPP  TG  CQ      V A    GGT  + PG       + 
Sbjct: 737 PCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMG 796

Query: 160 RTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISA 219
             G    G L P      S A             P GP    P  +       G  Q   
Sbjct: 797 FQGPRCEGKLRP------SCADSPCRNRATCQDSPQGPRCLCPTGYTG-----GSCQTLM 845

Query: 220 EVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRC 279
           ++ A  P                    +S+     PS H L         P    PL  C
Sbjct: 846 DLCAQKPCP-----------------RNSHCLQTGPSFHCL--CLQGWTGPLCNLPLSSC 886

Query: 280 FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQ---KPGPVRG- 335
            +  L +       +  L      C   G ++    CH  P  Q +  Q    P   R  
Sbjct: 887 QKAALSQ----GIDVSSLCHNGGLCVDSGPSY---FCHCPPGFQGSLCQDHVNPCESRPC 939

Query: 336 EVGADC---PQGY-----KRLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           + GA C   P GY        +  +C ++++ C       HG C   PG + C CPPG
Sbjct: 940 QNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPG 997



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 92/412 (22%), Positives = 128/412 (31%), Gaps = 80/412 (19%)

Query: 24  LALLLLLLLLLLGLGGRVEG---GPAGERGAGGGGALARE--RFKVVFAPVICKRTCLKG 78
           L LLLLLLLLL     R  G   G   E  A GG  L+    +     AP     TC   
Sbjct: 6   LLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETC--- 62

Query: 79  QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLP---------------------- 116
           Q  D CQ       + +NG S   L  +   +   P P                      
Sbjct: 63  QFPDPCQNAQ----LCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKL 118

Query: 117 --------CMNGGQC----SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGAL 164
                   C   G+C    S R QC C P +TG  CQ+    +       G  L+    +
Sbjct: 119 EDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQI 178

Query: 165 STGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAF-----LVPLGPGQISA 219
                P    EG +         V      PGP     + H        L P+G      
Sbjct: 179 QCHCPPGF--EGHACERD-----VNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRC 231

Query: 220 EVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRC 279
           E++A P         PP         +    + +     L P   P    P  +     C
Sbjct: 232 ELRAGP--------CPPRGCSNGGTCQLMPEKDSTFHLCLCP---PGFIGPDCEVNPDNC 280

Query: 280 FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSK-CHKCPQLQYTGVQKPGPVRGEVG 338
                     G     GL      C    T W  S+   +C        +  G  +   G
Sbjct: 281 VSHQCQN---GGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAG 337

Query: 339 A---DCPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCPPGHS 386
           +    C  G+     T C++  +  +   C  G  C++  GS+ C+CPPG +
Sbjct: 338 SFHCVCVSGW---GGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRT 386



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 22/61 (36%), Positives = 24/61 (39%), Gaps = 9/61 (14%)

Query: 114  PLPCMNGGQCSSRN-------QCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALST 166
            P PC+  G CS          +C CP    G  CQ P  GA G  G SG G    G    
Sbjct: 1137 PSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKP--GAKGCEGRSGDGACDAGCSGP 1194

Query: 167  G 167
            G
Sbjct: 1195 G 1195



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 14/29 (48%), Positives = 15/29 (51%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PC NGGQC  +     C C P F G  CQ
Sbjct: 559 PCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 116 PCMNGGQCSSRNQ---CLCPPDFTGRFCQVP 143
           PC  G  C        CLCP  FTG+ C+VP
Sbjct: 597 PCPVGASCLDLPGAFFCLCPSGFTGQLCEVP 627



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 27/93 (29%), Positives = 37/93 (39%), Gaps = 18/93 (19%)

Query: 74  TCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQC---SSRNQCL 130
           TC  G C    Q+ S +  +G  G   +   G          PC +GG C    S   C 
Sbjct: 666 TCHHGHC----QRSSCVCDVGWTGPECEAELGGCISA-----PCAHGGTCYPQPSGYNCT 716

Query: 131 CPPDFTGRFC--QVPAGGAG----GGTGGSGPG 157
           CP  +TG  C  ++ A  +G    GG+    PG
Sbjct: 717 CPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPG 749


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  202 bits (513), Expect = 2e-51
 Identities = 142/379 (37%), Positives = 183/379 (48%), Gaps = 48/379 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562

Query: 901 TQDQHGCEEVEQPHHKKEC 919
           +     CE +   H  +EC
Sbjct: 563 SAATR-CERL-PCHENREC 579



 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  154 bits (388), Expect = 7e-37
 Identities = 137/488 (28%), Positives = 182/488 (37%), Gaps = 132/488 (27%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126
              S   R C    E   +P               C+   A    ++  C CR+G      
Sbjct: 431  RLSVDGRSCEDINECSSSP---------------CSQECANVYGSY-QCYCRRG------ 468

Query: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG------R 1180
                                   +  S +        +  + ED DEC   +G      R
Sbjct: 469  -----------------------YQLSDV--------DGVTCEDIDECALPTGGHICSYR 497

Query: 1181 CVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236
            C+  PG   C CP  G++L  +   C DIDEC  +        +E C N  G FRC+   
Sbjct: 498  CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFE 555

Query: 1237 CKAGFARS 1244
            C   + RS
Sbjct: 556  CPENYRRS 563



 Score =  125 bits (315), Expect = 2e-28
 Identities = 117/395 (29%), Positives = 155/395 (39%), Gaps = 101/395 (25%)

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECD---------------------------- 831
             GSF+CQ    C +GY L+ D S C+DIDEC+                            
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 832  -------------------FPAAC-IGGDCINTNGSYRCL-----CPQGHRL-VGGRKCQ 865
                                 A C IG  CINT GSY C      C +G+ L   G +C 
Sbjct: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE--QPHHKKECYLNF 923
            D+DEC+     C     C N  GS+ C C  G+        C +V   Q +  + C    
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK- 414

Query: 924  DDTVFCDSVLATNVTQQECCCSLGAGWG---------DHCEIYPCP-----VYSSAEFHS 969
                 C++ L + +    C CS+G             + C   PC      VY S +   
Sbjct: 415  -----CENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ--- 462

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECML-FGSEICKEGKCVNTQPGYECYC-KQGFYY 1027
             C   +GY     + +       DIDEC L  G  IC   +C+N    ++C C   G+  
Sbjct: 463  -CYCRRGY----QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRL 516

Query: 1028 DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
              N   C D+DEC+    NC  N  C N +GG+RC
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  105 bits (262), Expect = 3e-22
 Identities = 110/433 (25%), Positives = 160/433 (36%), Gaps = 112/433 (25%)

Query: 836  CIGG-----DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGS 889
            C GG      C +T     C C  G++L+  G  C+D++EC      C    +C N  GS
Sbjct: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 890  YVCV----CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
            + C     C  G+  T+D + C+++++                C+S +   +    C  +
Sbjct: 240  FRCQRDSSCGTGYELTED-NSCKDIDE----------------CESGIHNCLPDFICQNT 282

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD--NNIVNYGIPAHRDIDECMLFGSE 1003
            LG+        + C      +         G+ QD   N +        DI+EC+   + 
Sbjct: 283  LGS--------FRCRPKLQCK--------SGFIQDALGNCI--------DINECLSISAP 318

Query: 1004 ICKEGKCVNTQPGYECY-----CKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRG 1056
                  C+NT+  Y C      C +G++ +     CVDVDEC   +  C  G  C N+ G
Sbjct: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC 1116
             +RC C     +    R C+   E +R P R  +C  +      C   L         C 
Sbjct: 379  SFRCECKTGYYFDGISRMCVDVNECQRYPGR--LCGHK------CENTLGSYL-----CS 425

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
            C  G       R C                                 ED +E  S  C  
Sbjct: 426  CSVGFRLSVDGRSC---------------------------------EDINECSSSPC-- 450

Query: 1177 VSGRCVPRPGGAVCECPGGFQL-DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1235
             S  C    G   C C  G+QL D     C DIDEC  L   G +C S RC+N  GSF+C
Sbjct: 451  -SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA-LPTGGHIC-SYRCINIPGSFQC 507

Query: 1236 VCKAGFARSRPHG 1248
             C +   R  P+G
Sbjct: 508  SCPSSGYRLAPNG 520



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
            N     +C+NT G +RC           + QC S                     G    
Sbjct: 272  NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301

Query: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
             L G  +  ++C             PCP    G  C  ++       +      G    +
Sbjct: 302  AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            E +   D DEC      C  G RCV  PG   CEC  G+  D     CVD++EC+     
Sbjct: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 408  GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 7/77 (9%)

Query: 1164 EDSSEEDSDECRCVSG-----RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRG 1218
            E+  E+     RC  G     +C       VC C  G+QL +    C D++EC   +   
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1219 LLCKSERCVNTSGSFRC 1235
             L   E C+NT GSFRC
Sbjct: 228  RL--GESCINTVGSFRC 242



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 8/83 (9%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 386 SLGPSRTQCIADKPEEKSLCFRL 408
               + T+C      E   C +L
Sbjct: 561 RRS-AATRCERLPCHENRECSKL 582



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  201 bits (512), Expect = 3e-51
 Identities = 134/351 (38%), Positives = 175/351 (49%), Gaps = 36/351 (10%)

Query: 568  APTQVTETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECE- 621
            A  +  + +EC  + + C  GE CV     + C+    C PGY        C DV+EC  
Sbjct: 760  AHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAM 817

Query: 622  -AEPCGPGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGF 675
                C PG  +C NT GS+ C     C  G+ L    G  +CVD+NEC      C  G  
Sbjct: 818  GTHTCQPGF-LCQNTKGSFYCQARQRCMDGF-LQDPEG--NCVDINECTSLSEPCRPGFS 873

Query: 676  CINFPGHYKCN-----CYPGYRLKASRPPVCEDIDECRDP-SSCPDGK-CENKPGSFKCI 728
            CIN  G Y C      C  GY         C D++EC      C +G+ C N PGS++C 
Sbjct: 874  CINTVGSYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRCGEGQVCHNLPGSYRC- 931

Query: 729  ACQPGY-RSQGGGACRDVNEC--AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
             C+ G+ R   G  C DVNEC  + G  C    CEN  GS+RC+CA G+  A DG+ C D
Sbjct: 932  DCKAGFQRDAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRCED 990

Query: 786  VDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDCINT 844
            V+ECEA        C+N  GS+QC C  GY L+ D   C DIDEC   A  +    C+N 
Sbjct: 991  VNECEAQRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNV 1048

Query: 845  NGSYRCLCP-QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893
             GSY+C CP QG+ +   GR C+D+DEC+     C     C N+QGS+ C+
Sbjct: 1049 PGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1099



 Score =  197 bits (502), Expect = 4e-50
 Identities = 168/517 (32%), Positives = 214/517 (41%), Gaps = 94/517 (18%)

Query: 616  DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC----------------- 658
            D +EC   P    + +C+NT GSY+C C  G+ L     GR+C                 
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ--DDGRTCRPEGHPPQPEAPQEPAL 661

Query: 659  -VDLNECA---------KPHLCGDGG----FCINFPGHYKCNCYPGYRLKASRPPVCEDI 704
              + ++ A         +P+ C D G     C    G   C+C+PGY + A     CED 
Sbjct: 662  KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS-CEDQ 720

Query: 705  DEC-RDPSSCPDGK-CENKPGSFKCI----ACQPGYRSQGGGACRDVNECAEG-SPCSPG 757
            DEC      C   + C N  GSF C+     C  GY       C D+NEC      CS G
Sbjct: 721  DECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRG 780

Query: 758  -WCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNTPGSFQCQ 810
              C N  GSF C    TC  GYA   DG  C DVDEC  G   C  G +C NT GSF CQ
Sbjct: 781  EHCVNTLGSFHCYKALTCEPGYA-LKDGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYCQ 838

Query: 811  ----CLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRC-----LCPQG-HRL 858
                C+ G+ L     +C DI+EC      C  G  CINT GSY C     +C +G H  
Sbjct: 839  ARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHAS 897

Query: 859  VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE 918
              G KC D++EC      C     C NL GSY C C  GF       GC +V       E
Sbjct: 898  DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDV------NE 951

Query: 919  CYLNFDDTVFCDSVLATNVTQQECCCSLG---AGWGDHCE-IYPCPVYSSAE-------- 966
            C+ +      C       +    C C+ G   A  G  CE +  C     ++        
Sbjct: 952  CWAS--PGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGS 1009

Query: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC-KQGF 1025
            +   C  G    +D +          DIDEC   G+ I    +C+N    Y+C C +QG+
Sbjct: 1010 YQCYCRQGYQLAEDGHTCT-------DIDECAQ-GAGILCTFRCLNVPGSYQCACPEQGY 1061

Query: 1026 YYDGNLLECVDVDEC-LDESNCRNG-VCENTRGGYRC 1060
                N   C DVDEC L   NC     C N +G +RC
Sbjct: 1062 TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC 1098



 Score =  162 bits (411), Expect = 1e-39
 Identities = 203/820 (24%), Positives = 289/820 (35%), Gaps = 164/820 (20%)

Query: 484  PDGPPKPQ-------QLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPA 536
            P  P KP         LP++ +  PP  +   +  V   S V E+      H    ++P 
Sbjct: 377  PRDPVKPSPHNILSTSLPDA-AWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPE 435

Query: 537  RPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPD 596
                +LI        +W + +       +EI P   TE + CR  Q  C    CV    +
Sbjct: 436  GSTKDLIETCCAAGQQWAIDN----DECLEI-PESGTEDNVCRTAQRHC----CVSYLQE 486

Query: 597  YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
             SC                 +   E E CG              C    G  L V A G+
Sbjct: 487  KSCMAGV-------------LGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 657  SCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDG 716
            SC      + P+L    G+  N   H   +C  G       P +  ++    +P++ P  
Sbjct: 534  SCE-----SNPNL----GYPCN---HVMLSCCEG-----EEPLIVPEVRRPPEPAAAPRR 576

Query: 717  KCENKPGSFKCIACQPGYRSQGGGACRDVNECA--EGSPCSPGWCENLPGSFRCTCAQGY 774
              E +    + ++              D +EC    G  C    C N  GS+ C C  G+
Sbjct: 577  VSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQH-LCINTVGSYHCACFPGF 635

Query: 775  APAPDGRSC----------------------------LDVDECEAGDVCDNG----ICSN 802
            +   DGR+C                            + +   +     DNG    +CS 
Sbjct: 636  SLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCST 695

Query: 803  TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINTNGSYRC-----LCPQG 855
              GS  C C  GY +  D   CED DEC   A        C+NT GS+ C     LC  G
Sbjct: 696  VGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADG 755

Query: 856  HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDEGFTPTQDQHGCEEVE 911
            + L   RKC DI+EC  D   C     C N  GS+ C     C+ G+     +  CE+V+
Sbjct: 756  YILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVD 813

Query: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLC 971
                  EC             + T+  Q    C    G   +C+               C
Sbjct: 814  ------EC------------AMGTHTCQPGFLCQNTKG-SFYCQA-----------RQRC 843

Query: 972  PDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECY-----CKQGF 1025
             DG     + N V        DI+EC    SE C+ G  C+NT   Y C      C +G+
Sbjct: 844  MDGFLQDPEGNCV--------DINECTSL-SEPCRPGFSCINTVGSYTCQRNPLICARGY 894

Query: 1026 YYDGNLLECVDVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMER 1083
            +   +  +CVDV+EC      C  G VC N  G YRC C    +     R C+   E   
Sbjct: 895  HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE--- 951

Query: 1084 APERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQ 1143
                   CW+  G   +C         ++  C C  G    A  + C           SQ
Sbjct: 952  -------CWASPGR--LCQHTCENTLGSYR-CSCASGFLLAADGKRCEDVNECEAQRCSQ 1001

Query: 1144 SESNSFWDTSPLLL-GKPPRDEDSSEEDSDECRCVSG-----RCVPRPGGAVCECPG-GF 1196
              +N +         G    ++  +  D DEC   +G     RC+  PG   C CP  G+
Sbjct: 1002 ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGY 1061

Query: 1197 QLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
             + A+   C D+DEC          ++E C N  GSFRC+
Sbjct: 1062 TMTANGRSCKDVDECALGTHN--CSEAETCHNIQGSFRCL 1099



 Score =  137 bits (344), Expect = 8e-32
 Identities = 85/233 (36%), Positives = 114/233 (48%), Gaps = 18/233 (7%)

Query: 570  TQVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
            T+  + +EC    + CG G+ C   P  Y C C  G++     R C+DVNEC A P    
Sbjct: 901  TKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC 960

Query: 629  RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCY 688
            +  C NT GSY C C  G+ L   A G+ C D+NEC       +   C N  G Y+C C 
Sbjct: 961  QHTCENTLGSYRCSCASGFLL--AADGKRCEDVNECEAQRCSQE---CANIYGSYQCYCR 1015

Query: 689  PGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIACQPGY-RSQGGGACRDVN 746
             GY+L A     C DIDEC   +      +C N PGS++C   + GY  +  G +C+DV+
Sbjct: 1016 QGYQL-AEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1074

Query: 747  ECAEGS-PCSPG-WCENLPGSFRC---TCAQGYAPAP----DGRSCLDVDECE 790
            ECA G+  CS    C N+ GSFRC    C   Y        +  +C D  EC+
Sbjct: 1075 ECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1127



 Score =  112 bits (280), Expect = 2e-24
 Identities = 130/468 (27%), Positives = 180/468 (38%), Gaps = 142/468 (30%)

Query: 825  EDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDID-----ECSQDPSL- 876
            +D DEC   P       CINT GSY C C  G  L   GR C+        E  Q+P+L 
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 877  --------------------CLPHGACKNL----QGSYVCVCDEGFTPTQDQHGCEEVEQ 912
                                C  +G CK +     GS +C C  G+    D   CE+ + 
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQD- 721

Query: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
                 EC +   D   C         +Q C  +LG+             +       LC 
Sbjct: 722  -----ECLMGAHD---CSR-------RQFCVNTLGS-------------FYCVNHTVLCA 753

Query: 973  DGKGYTQDNNIVNYGIPAHR---DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQG 1024
            DG           Y + AHR   DI+EC+      C  G+ CVNT   + CY    C+ G
Sbjct: 754  DG-----------YILNAHRKCVDINECVT-DLHTCSRGEHCVNTLGSFHCYKALTCEPG 801

Query: 1025 FYY-DGNLLECVDVDEC-LDESNCRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEM 1081
            +   DG   EC DVDEC +    C+ G +C+NT+G + C          A+++C+     
Sbjct: 802  YALKDG---ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQ---------ARQRCM----- 844

Query: 1082 ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPT 1141
                            DG    P  G  +  ++C         +   PC P   G  C  
Sbjct: 845  ----------------DGFLQDP-EGNCVDINECT--------SLSEPCRP---GFSCIN 876

Query: 1142 SQSESNSFWDTSPLLL--GKPPRDEDSSEEDSDEC-----RCVSGR-CVPRPGGAVCECP 1193
            +          +PL+   G    D+ +   D +EC     RC  G+ C   PG   C+C 
Sbjct: 877  TVGSYTC--QRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCK 934

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
             GFQ DA    C+D++EC      G LC+   C NT GS+RC C +GF
Sbjct: 935  AGFQRDAFGRGCIDVNEC--WASPGRLCQ-HTCENTLGSYRCSCASGF 979



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 102/413 (24%), Positives = 145/413 (35%), Gaps = 96/413 (23%)

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE---EVEQPHHKKECYLN 922
            D DEC   P     H  C N  GSY C C  GF+   D   C       QP   +E  L 
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 923  FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP-VYSSAEFHSLCPDGKGYTQDN 981
             + +    + +   + Q   C   G          PC  V S+    ++C    GY    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNG----------PCKQVCSTVGGSAICSCFPGYA--- 709

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL----ECVDV 1037
             I+  G+    D DEC++   +  +   CVNT   + C        DG +L    +CVD+
Sbjct: 710  -IMADGVSCE-DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDI 767

Query: 1038 DECL-DESNCRNGV-CENTRGGYRC--ACTPPAEYSPAQRQCLSPEEMERAPERRDVCWS 1093
            +EC+ D   C  G  C NT G + C  A T    Y+    +C   +E             
Sbjct: 768  NECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDE------------- 814

Query: 1094 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP---CPPRGAGSHCPTSQSESNSFW 1150
                                   C  G      C+P   C       +C   Q   + F 
Sbjct: 815  -----------------------CAMGTH---TCQPGFLCQNTKGSFYCQARQRCMDGFL 848

Query: 1151 DTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP------RPGGAVCE-----CPGGFQLD 1199
                       +D + +  D +EC  +S  C P        G   C+     C  G+   
Sbjct: 849  -----------QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHAS 897

Query: 1200 ASRARCVDIDECRELNQRGLLC-KSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
                +CVD++EC     R   C + + C N  GS+RC CKAGF R      C+
Sbjct: 898  DDGTKCVDVNECETGVHR---CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 947



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 47/147 (31%), Positives = 59/147 (40%), Gaps = 24/147 (16%)

Query: 341  CPQGYKRLNS-THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIA 396
            C +GY   +  T C D+NEC   GV R G+   C N PGSYRC C  G         CI 
Sbjct: 890  CARGYHASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI- 947

Query: 397  DKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARC--------QRCPT 445
                + + C+   SP   CQH     L    C C+ G    A G RC        QRC  
Sbjct: 948  ----DVNECW--ASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ 1001

Query: 446  DGTAAFKEI-CPAGKGYHILTSHQTLT 471
            +    +    C   +GY +     T T
Sbjct: 1002 ECANIYGSYQCYCRQGYQLAEDGHTCT 1028



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 12/119 (10%)

Query: 282 DTLPKQPCGSNPL---PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
           +T+    C  NPL    G    +D    +     ++  H+C + Q      PG  R    
Sbjct: 876 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCH-NLPGSYR---- 930

Query: 339 ADCPQGYKR-LNSTHCQDINEC-AMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
            DC  G++R      C D+NEC A PG +C+H  C N  GSYRC C  G  L     +C
Sbjct: 931 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRC 988



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 328  QKPGPVRGEVGADCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCP-PG 384
            Q+   + G     C QGY+     H C DI+ECA   G+     CLN PGSY+C CP  G
Sbjct: 1001 QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQG 1060

Query: 385  HSLGPSRTQC 394
            +++  +   C
Sbjct: 1061 YTMTANGRSC 1070



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 8/69 (11%)

Query: 333  VRGEVGADCP-QGYKRL-NSTHCQDINECAM-PGVCRHGD-CLNNPGSYRCV---CPPGH 385
            V G     CP QGY    N   C+D++ECA+    C   + C N  GS+RC+   CPP +
Sbjct: 1048 VPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1107

Query: 386  SLGPSRTQC 394
             +  S+T+C
Sbjct: 1108 -VQVSKTKC 1115



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 3/48 (6%)

Query: 349 NSTHCQDINECAM-PG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           NS    D +EC + PG +C+H  C+N  GSY C C PG SL      C
Sbjct: 598 NSLPGDDQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTC 644



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 58/227 (25%), Positives = 75/227 (33%), Gaps = 41/227 (18%)

Query: 1035 VDVDECLD--ESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERA-PERRDVC 1091
            +D DECL+  ES   + VC   R   R  C    +        L  +E E    E  D C
Sbjct: 454  IDNDECLEIPESGTEDNVC---RTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSC 510

Query: 1092 WSQRGEDGMCAGPLAGPALTFDDC-CCRQG---RGWGAQCRPCPPRGAG-SHCPTSQSES 1146
                           G +L    C CC  G   R  G  C   P  G   +H   S  E 
Sbjct: 511  ---------------GISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEG 555

Query: 1147 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCV 1206
                   PL++ +  R  + +                   G   E P     D       
Sbjct: 556  EE-----PLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGD------- 603

Query: 1207 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1253
            D DEC  L   G LC+   C+NT GS+ C C  GF+       C P+
Sbjct: 604  DQDECLLLP--GELCQ-HLCINTVGSYHCACFPGFSLQDDGRTCRPE 647



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 6/53 (11%)

Query: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGD-CLNNPGSYRC----VCPPGHSL 387
           C  GY       C DINEC      C  G+ C+N  GS+ C     C PG++L
Sbjct: 752 CADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYAL 804



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 3/41 (7%)

Query: 341 CPQGYKRLNSTHCQDINECAM-PGVCRHGD-CLNNPGSYRC 379
           C  GY  L    C+D++ECAM    C+ G  C N  GS+ C
Sbjct: 798 CEPGYA-LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC 837


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  201 bits (511), Expect = 4e-51
 Identities = 148/446 (33%), Positives = 193/446 (43%), Gaps = 71/446 (15%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY---C 1021
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C    C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRCLAFEC 556

Query: 1022 KQGFYYDGNLLECVDVDECLDESNCR 1047
             + +      L+    D      +CR
Sbjct: 557  PENYRRSAATLQQEKTDTVRCIKSCR 582



 Score =  201 bits (510), Expect = 5e-51
 Identities = 143/388 (36%), Positives = 184/388 (47%), Gaps = 46/388 (11%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562

Query: 901 TQDQHGCEEVEQPHHKKECYLNFDDTVF 928
           +      E+ +     K C  N    VF
Sbjct: 563 SAATLQQEKTDTVRCIKSCRPNDVTCVF 590



 Score =  154 bits (388), Expect = 7e-37
 Identities = 137/488 (28%), Positives = 182/488 (37%), Gaps = 132/488 (27%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126
              S   R C    E   +P               C+   A    ++  C CR+G      
Sbjct: 431  RLSVDGRSCEDINECSSSP---------------CSQECANVYGSY-QCYCRRG------ 468

Query: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG------R 1180
                                   +  S +        +  + ED DEC   +G      R
Sbjct: 469  -----------------------YQLSDV--------DGVTCEDIDECALPTGGHICSYR 497

Query: 1181 CVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236
            C+  PG   C CP  G++L  +   C DIDEC  +        +E C N  G FRC+   
Sbjct: 498  CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFE 555

Query: 1237 CKAGFARS 1244
            C   + RS
Sbjct: 556  CPENYRRS 563



 Score =  125 bits (315), Expect = 2e-28
 Identities = 117/395 (29%), Positives = 155/395 (39%), Gaps = 101/395 (25%)

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECD---------------------------- 831
             GSF+CQ    C +GY L+ D S C+DIDEC+                            
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 832  -------------------FPAAC-IGGDCINTNGSYRCL-----CPQGHRL-VGGRKCQ 865
                                 A C IG  CINT GSY C      C +G+ L   G +C 
Sbjct: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE--QPHHKKECYLNF 923
            D+DEC+     C     C N  GS+ C C  G+        C +V   Q +  + C    
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK- 414

Query: 924  DDTVFCDSVLATNVTQQECCCSLGAGWG---------DHCEIYPCP-----VYSSAEFHS 969
                 C++ L + +    C CS+G             + C   PC      VY S +   
Sbjct: 415  -----CENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ--- 462

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECML-FGSEICKEGKCVNTQPGYECYC-KQGFYY 1027
             C   +GY     + +       DIDEC L  G  IC   +C+N    ++C C   G+  
Sbjct: 463  -CYCRRGY----QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRL 516

Query: 1028 DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
              N   C D+DEC+    NC  N  C N +GG+RC
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  105 bits (262), Expect = 3e-22
 Identities = 110/433 (25%), Positives = 160/433 (36%), Gaps = 112/433 (25%)

Query: 836  CIGG-----DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGS 889
            C GG      C +T     C C  G++L+  G  C+D++EC      C    +C N  GS
Sbjct: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 890  YVCV----CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
            + C     C  G+  T+D + C+++++                C+S +   +    C  +
Sbjct: 240  FRCQRDSSCGTGYELTED-NSCKDIDE----------------CESGIHNCLPDFICQNT 282

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD--NNIVNYGIPAHRDIDECMLFGSE 1003
            LG+        + C      +         G+ QD   N +        DI+EC+   + 
Sbjct: 283  LGS--------FRCRPKLQCK--------SGFIQDALGNCI--------DINECLSISAP 318

Query: 1004 ICKEGKCVNTQPGYECY-----CKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRG 1056
                  C+NT+  Y C      C +G++ +     CVDVDEC   +  C  G  C N+ G
Sbjct: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC 1116
             +RC C     +    R C+   E +R P R  +C  +      C   L         C 
Sbjct: 379  SFRCECKTGYYFDGISRMCVDVNECQRYPGR--LCGHK------CENTLGSYL-----CS 425

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
            C  G       R C                                 ED +E  S  C  
Sbjct: 426  CSVGFRLSVDGRSC---------------------------------EDINECSSSPC-- 450

Query: 1177 VSGRCVPRPGGAVCECPGGFQL-DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1235
             S  C    G   C C  G+QL D     C DIDEC  L   G +C S RC+N  GSF+C
Sbjct: 451  -SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA-LPTGGHIC-SYRCINIPGSFQC 507

Query: 1236 VCKAGFARSRPHG 1248
             C +   R  P+G
Sbjct: 508  SCPSSGYRLAPNG 520



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
            N     +C+NT G +RC           + QC S                     G    
Sbjct: 272  NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301

Query: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
             L G  +  ++C             PCP    G  C  ++       +      G    +
Sbjct: 302  AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            E +   D DEC      C  G RCV  PG   CEC  G+  D     CVD++EC+     
Sbjct: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 408  GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 7/77 (9%)

Query: 1164 EDSSEEDSDECRCVSG-----RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRG 1218
            E+  E+     RC  G     +C       VC C  G+QL +    C D++EC   +   
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1219 LLCKSERCVNTSGSFRC 1235
             L   E C+NT GSFRC
Sbjct: 228  RL--GESCINTVGSFRC 242



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  200 bits (508), Expect = 8e-51
 Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+  E
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555



 Score =  127 bits (318), Expect = 9e-29
 Identities = 126/440 (28%), Positives = 169/440 (38%), Gaps = 108/440 (24%)

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECD---------------------------- 831
             GSF+CQ    C +GY L+ D S C+DIDEC+                            
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 832  -------------------FPAAC-IGGDCINTNGSYRCL-----CPQGHRL-VGGRKCQ 865
                                 A C IG  CINT GSY C      C +G+ L   G +C 
Sbjct: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE--QPHHKKECYLNF 923
            D+DEC+     C     C N  GS+ C C  G+        C +V   Q +  + C    
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK- 414

Query: 924  DDTVFCDSVLATNVTQQECCCSLGAGWG---------DHCEIYPCP-----VYSSAEFHS 969
                 C++ L + +    C CS+G             + C   PC      VY S +   
Sbjct: 415  -----CENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ--- 462

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECML-FGSEICKEGKCVNTQPGYECYC-KQGFYY 1027
             C   +GY     + +       DIDEC L  G  IC   +C+N    ++C C   G+  
Sbjct: 463  -CYCRRGY----QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRL 516

Query: 1028 DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC---ACTPPAEYSPAQRQCLSPEEME 1082
              N   C D+DEC+    NC  N  C N +GG+RC    C      S A ++     +  
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNT 576

Query: 1083 RAPERRDVC----WSQRGED 1098
             A   ++ C    W Q  ED
Sbjct: 577  PAGSSKEDCRVLPWKQGLED 596



 Score =  112 bits (279), Expect = 3e-24
 Identities = 114/440 (25%), Positives = 169/440 (38%), Gaps = 87/440 (19%)

Query: 836  CIGG-----DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGS 889
            C GG      C +T     C C  G++L+  G  C+D++EC      C    +C N  GS
Sbjct: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 890  YVCV----CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
            + C     C  G+  T+D + C+++++                C+S +   +    C  +
Sbjct: 240  FRCQRDSSCGTGYELTED-NSCKDIDE----------------CESGIHNCLPDFICQNT 282

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD--NNIVNYGIPAHRDIDECMLFGSE 1003
            LG+        + C      +         G+ QD   N +        DI+EC+   + 
Sbjct: 283  LGS--------FRCRPKLQCK--------SGFIQDALGNCI--------DINECLSISAP 318

Query: 1004 ICKEGKCVNTQPGYECY-----CKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRG 1056
                  C+NT+  Y C      C +G++ +     CVDVDEC   +  C  G  C N+ G
Sbjct: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC 1116
             +RC C     +    R C+   E +R P R  +C  +      C   L         C 
Sbjct: 379  SFRCECKTGYYFDGISRMCVDVNECQRYPGR--LCGHK------CENTLGSYL-----CS 425

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL-LGKPPRDEDS-SEEDSDEC 1174
            C  G       R C      S  P SQ  +N +         G    D D  + ED DEC
Sbjct: 426  CSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485

Query: 1175 RCVSG------RCVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCV 1227
               +G      RC+  PG   C CP  G++L  +   C DIDEC  +        +E C 
Sbjct: 486  ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCF 543

Query: 1228 NTSGSFRCV---CKAGFARS 1244
            N  G FRC+   C   + RS
Sbjct: 544  NIQGGFRCLAFECPENYRRS 563



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
            N     +C+NT G +RC           + QC S                     G    
Sbjct: 272  NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301

Query: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
             L G  +  ++C             PCP    G  C  ++       +      G    +
Sbjct: 302  AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            E +   D DEC      C  G RCV  PG   CEC  G+  D     CVD++EC+     
Sbjct: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 408  GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 98/399 (24%), Positives = 128/399 (32%), Gaps = 98/399 (24%)

Query: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218

Query: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252

Query: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303

Query: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD 1089
              C+D++ECL  S  C  G  C NT G Y C    P         C     +     R  
Sbjct: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP--------NCGRGYHLNEEGTR-- 353

Query: 1090 VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSF 1149
                                +  D+C             P  P G G  C  S       
Sbjct: 354  -------------------CVDVDECA-----------PPAEPCGKGHRCVNSPGSFRCE 383

Query: 1150 WDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDID 1209
              T     G      D +E      R    +C    G  +C C  GF+L      C DI+
Sbjct: 384  CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443

Query: 1210 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248
            EC         C S+ C N  GS++C C+ G+  S   G
Sbjct: 444  ECSSSP-----C-SQECANVYGSYQCYCRRGYQLSDVDG 476



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  200 bits (509), Expect = 6e-51
 Identities = 143/415 (34%), Positives = 184/415 (44%), Gaps = 68/415 (16%)

Query: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYK 684
            GP +  C +TG    C C  GY+L   + G SC D+NEC    H C  G  CIN  G ++
Sbjct: 184  GPCKQQCRDTGDEVVCSCFVGYQLL--SDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241

Query: 685  C----NCYPGYRLKASRPPVCEDIDECRD--PSSCPDGKCENKPGSFKC---IACQPGYR 735
            C    +C  GY L       C+DIDEC     +  PD  C+N  GSF+C   + C+ G+ 
Sbjct: 242  CQRDSSCGTGYELTEDNS--CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299

Query: 736  SQGGGACRDVNECAE-GSPCSPG-WCENLPGSFRC-----TCAQGYAPAPDGRSCLDVDE 788
                G C D+NEC    +PC  G  C N  GS+ C      C +GY    +G  C+DVDE
Sbjct: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359

Query: 789  C-EAGDVCDNG-ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTN 845
            C    + C  G  C N+PGSF+C+C +GY+       C D++EC  +P    G  C NT 
Sbjct: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419

Query: 846  GSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQ 904
            GSY C C  G RL V GR C+DI+ECS  P        C N+ GSY C C  G+      
Sbjct: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPC----SQECANVYGSYQCYCRRGY------ 469

Query: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
                            L+  D V C+ +        EC    G     H   Y C +   
Sbjct: 470  ---------------QLSDVDGVTCEDI-------DECALPTGG----HICSYRC-INIP 502

Query: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
              F   CP   GY    N  N      +DIDEC+           C N Q G+ C
Sbjct: 503  GSFQCSCP-SSGYRLAPNGRNC-----QDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  200 bits (508), Expect = 8e-51
 Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)

Query: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274

Query: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388

Query: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447

Query: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502

Query: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+  E
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555



 Score =  154 bits (388), Expect = 7e-37
 Identities = 137/488 (28%), Positives = 182/488 (37%), Gaps = 132/488 (27%)

Query: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317

Query: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370

Query: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126
              S   R C    E   +P               C+   A    ++  C CR+G      
Sbjct: 431  RLSVDGRSCEDINECSSSP---------------CSQECANVYGSY-QCYCRRG------ 468

Query: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG------R 1180
                                   +  S +        +  + ED DEC   +G      R
Sbjct: 469  -----------------------YQLSDV--------DGVTCEDIDECALPTGGHICSYR 497

Query: 1181 CVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236
            C+  PG   C CP  G++L  +   C DIDEC  +        +E C N  G FRC+   
Sbjct: 498  CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFE 555

Query: 1237 CKAGFARS 1244
            C   + RS
Sbjct: 556  CPENYRRS 563



 Score =  125 bits (315), Expect = 2e-28
 Identities = 117/395 (29%), Positives = 155/395 (39%), Gaps = 101/395 (25%)

Query: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECD---------------------------- 831
             GSF+CQ    C +GY L+ D S C+DIDEC+                            
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 832  -------------------FPAAC-IGGDCINTNGSYRCL-----CPQGHRL-VGGRKCQ 865
                                 A C IG  CINT GSY C      C +G+ L   G +C 
Sbjct: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE--QPHHKKECYLNF 923
            D+DEC+     C     C N  GS+ C C  G+        C +V   Q +  + C    
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK- 414

Query: 924  DDTVFCDSVLATNVTQQECCCSLGAGWG---------DHCEIYPCP-----VYSSAEFHS 969
                 C++ L + +    C CS+G             + C   PC      VY S +   
Sbjct: 415  -----CENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ--- 462

Query: 970  LCPDGKGYTQDNNIVNYGIPAHRDIDECML-FGSEICKEGKCVNTQPGYECYC-KQGFYY 1027
             C   +GY     + +       DIDEC L  G  IC   +C+N    ++C C   G+  
Sbjct: 463  -CYCRRGY----QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRL 516

Query: 1028 DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
              N   C D+DEC+    NC  N  C N +GG+RC
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  105 bits (262), Expect = 3e-22
 Identities = 110/433 (25%), Positives = 160/433 (36%), Gaps = 112/433 (25%)

Query: 836  CIGG-----DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGS 889
            C GG      C +T     C C  G++L+  G  C+D++EC      C    +C N  GS
Sbjct: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 890  YVCV----CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
            + C     C  G+  T+D + C+++++                C+S +   +    C  +
Sbjct: 240  FRCQRDSSCGTGYELTED-NSCKDIDE----------------CESGIHNCLPDFICQNT 282

Query: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQD--NNIVNYGIPAHRDIDECMLFGSE 1003
            LG+        + C      +         G+ QD   N +        DI+EC+   + 
Sbjct: 283  LGS--------FRCRPKLQCK--------SGFIQDALGNCI--------DINECLSISAP 318

Query: 1004 ICKEGKCVNTQPGYECY-----CKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRG 1056
                  C+NT+  Y C      C +G++ +     CVDVDEC   +  C  G  C N+ G
Sbjct: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC 1116
             +RC C     +    R C+   E +R P R  +C  +      C   L         C 
Sbjct: 379  SFRCECKTGYYFDGISRMCVDVNECQRYPGR--LCGHK------CENTLGSYL-----CS 425

Query: 1117 CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC 1176
            C  G       R C                                 ED +E  S  C  
Sbjct: 426  CSVGFRLSVDGRSC---------------------------------EDINECSSSPC-- 450

Query: 1177 VSGRCVPRPGGAVCECPGGFQL-DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1235
             S  C    G   C C  G+QL D     C DIDEC  L   G +C S RC+N  GSF+C
Sbjct: 451  -SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA-LPTGGHIC-SYRCINIPGSFQC 507

Query: 1236 VCKAGFARSRPHG 1248
             C +   R  P+G
Sbjct: 508  SCPSSGYRLAPNG 520



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)

Query: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271

Query: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
            N     +C+NT G +RC           + QC S                     G    
Sbjct: 272  NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301

Query: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
             L G  +  ++C             PCP    G  C  ++       +      G    +
Sbjct: 302  AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            E +   D DEC      C  G RCV  PG   CEC  G+  D     CVD++EC+     
Sbjct: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 408  GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                + + C R   P   C H     L   LC CSVG
Sbjct: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510

Query: 383 -PGHSLGPSRTQC 394
             G+ L P+   C
Sbjct: 511 SSGYRLAPNGRNC 523



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 7/77 (9%)

Query: 1164 EDSSEEDSDECRCVSG-----RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRG 1218
            E+  E+     RC  G     +C       VC C  G+QL +    C D++EC   +   
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1219 LLCKSERCVNTSGSFRC 1235
             L   E C+NT GSFRC
Sbjct: 228  RL--GESCINTVGSFRC 242



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416

Query: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
           N  GSY C C  G  L      C
Sbjct: 417 NTLGSYLCSCSVGFRLSVDGRSC 439



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343

Query: 384 GHSLGPSRTQCI 395
           G+ L    T+C+
Sbjct: 344 GYHLNEEGTRCV 355



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)

Query: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 375 GSYRC 379
           GS+RC
Sbjct: 284 GSFRC 288


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  196 bits (499), Expect = 9e-50
 Identities = 218/804 (27%), Positives = 304/804 (37%), Gaps = 180/804 (22%)

Query: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
            D+C  N   C HG C+ G   YSC C+PG+      R  +D++EC + PC  G   C+N 
Sbjct: 647  DDCASNP--CIHGICMDGINRYSCVCSPGFTGQ---RCNIDIDECASNPCRKG-ATCING 700

Query: 636  GGSYNCHCNRG-----------------------------YRLHVGAG--GRSC-VDLNE 663
               + C C  G                             Y+    AG  G +C VD NE
Sbjct: 701  VNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNE 760

Query: 664  CAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG 723
            C   + C +GG C N    Y+C C  G++    +     +IDEC        G C +   
Sbjct: 761  CLS-NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQV----NIDECASNPCLNQGTCFDDIS 815

Query: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP--------GSFRCTCAQGYA 775
             + C    P      G  C+ V      +PCSP  CEN           S+ C CA G+ 
Sbjct: 816  GYTCHCVLP----YTGKNCQTVL-----APCSPNPCENAAVCKESPNFESYTCLCAPGW- 865

Query: 776  PAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC-EDIDECDFP 833
                G+ C +D+DEC +    ++G+C NT GS+ C+C  G+        C EDID+C   
Sbjct: 866  ---QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGF----SGMDCEEDIDDCLAN 918

Query: 834  AACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-DIDECSQDPSLCLPHGACKNLQGSYVC 892
                GG C++   ++ CLC  G     G KCQ D++EC  +P  C   G C +   SY C
Sbjct: 919  PCQNGGSCMDGVNTFSCLCLPGFT---GDKCQTDMNECLSEP--CKNGGTCSDYVNSYTC 973

Query: 893  VCDEGFTPTQDQHGCEEVEQP-------------HHKKECYLNFDDTVFC---------- 929
             C  GF     ++   E  +                   C + F  + FC          
Sbjct: 974  KCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGS-FCLHEINECSSH 1032

Query: 930  ----DSVLATNVTQQECCCSLGAGWGDHCEIY-------PCP-----VYSSAEFHSLCPD 973
                +      +    C C LG   G +C+         PC      V   AE   LCP 
Sbjct: 1033 PCLNEGTCVDGLGTYRCSCPLGY-TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPS 1091

Query: 974  G-KGYTQDNNIVNYGIPAHRDIDECMLFGSEICK-EGKCVNTQPGYECYCKQGFYYDGNL 1031
            G  G   D   V+  I A R      +    +C+  G C+N    + C C  G  Y G+ 
Sbjct: 1092 GWAGAYCDVPNVSCDIAASRR----GVLVEHLCQHSGVCINAGNTHYCQCPLG--YTGSY 1145

Query: 1032 LECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVC 1091
             E   +DEC          C +  GGYRC C P  +    + +    +E +  P +    
Sbjct: 1146 CE-EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEV---DECQNQPCQNGGT 1201

Query: 1092 WSQRGEDGMCAGPLAGPAL----TFDDCC----CRQG-----RGWGAQCRPCPPRGAGSH 1138
                     C+ P     L      DDC     C  G     R  G  CR C P  AG  
Sbjct: 1202 CIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCR-CLPGFAGER 1260

Query: 1139 CPTSQSESNSFWDTSP------------LLLGKPPRDEDSSEEDSDEC---RCVS-GRCV 1182
            C    +E  S   +S             L + +        E   D C    C++ G C 
Sbjct: 1261 CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCA 1320

Query: 1183 ---PRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236
                 P G +C CP GF    S ARC     C ++  R    K E+CV+T+   RC    
Sbjct: 1321 VASNMPDGFICRCPPGF----SGARCQ--SSCGQVKCR----KGEQCVHTASGPRCFCPS 1370

Query: 1237 ---CKAGFARS--RPHGACVPQRR 1255
               C++G A S  +  G+C PQR+
Sbjct: 1371 PRDCESGCASSPCQHGGSCHPQRQ 1394



 Score =  194 bits (492), Expect = 6e-49
 Identities = 190/737 (25%), Positives = 292/737 (39%), Gaps = 165/737 (22%)

Query: 574  ETDECRL-NQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGI 631
            + DEC + N N C H G+CV     + C C  GY      R  +D+NEC ++PC      
Sbjct: 415  DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGP---RCEMDINECHSDPC-QNDAT 470

Query: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPG 690
            C++  G + C C  G++      G  C +++NEC + + C + G C++    ++C C PG
Sbjct: 471  CLDKIGGFTCLCMPGFK------GVHCELEINEC-QSNPCVNNGQCVDKVNRFQCLCPPG 523

Query: 691  YRLKASRPPVCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
            +       PVC+ DID+C         KC + P  ++C  C  G+    G  C +  +  
Sbjct: 524  FT-----GPVCQIDIDDCSSTPCLNGAKCIDHPNGYEC-QCATGFT---GVLCEENIDNC 574

Query: 750  EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGICSNTPGSFQ 808
            +  PC  G C++   S+ C C  GY     G  C D +DEC +    ++G C +    +Q
Sbjct: 575  DPDPCHHGQCQDGIDSYTCICNPGYM----GAICSDQIDECYSSPCLNDGRCIDLVNGYQ 630

Query: 809  CQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ-D 866
            C C  G        +CE + D+C     CI G C++    Y C+C  G     G++C  D
Sbjct: 631  CNCQPG----TSGVNCEINFDDCA-SNPCIHGICMDGINRYSCVCSPGFT---GQRCNID 682

Query: 867  IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT 926
            IDEC+ +P  C     C N    + C+C EG               PHH   CY   ++ 
Sbjct: 683  IDECASNP--CRKGATCINGVNGFRCICPEG---------------PHHPS-CYSQVNEC 724

Query: 927  VFCDSVLAT---NVTQQECCCSLGAGW-GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNN 982
            +    +       ++  +C C   AGW G +CE+      S+       P   G T DN 
Sbjct: 725  LSNPCIHGNCTGGLSGYKCLCD--AGWVGINCEVDKNECLSN-------PCQNGGTCDNL 775

Query: 983  IVNY---------GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC------------ 1021
            +  Y         G     +IDEC    +    +G C +   GY C+C            
Sbjct: 776  VNGYRCTCKKGFKGYNCQVNIDECA--SNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTV 833

Query: 1022 ---------------KQGFYYDGNLLEC----------VDVDECLDESNCRNGVCENTRG 1056
                           K+   ++     C          +D+DEC+ +    +G+C NT+G
Sbjct: 834  LAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQG 893

Query: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC 1116
             Y C C P       +             E  D C +   ++G   G       TF  C 
Sbjct: 894  SYMCECPPGFSGMDCE-------------EDIDDCLANPCQNG---GSCMDGVNTF-SCL 936

Query: 1117 CRQGRGWGAQCR---------PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1167
            C  G   G +C+         PC   G      T     NS+  T     G      +++
Sbjct: 937  CLPG-FTGDKCQTDMNECLSEPCKNGG------TCSDYVNSY--TCKCQAGFDGVHCENN 987

Query: 1168 EEDSDECRCVS-GRCVPRPGGAVCECPGGFQLDASRARCV-DIDECRELNQRGLLCKSE- 1224
              +  E  C + G CV       C CP GF    + + C+ +I+EC         C +E 
Sbjct: 988  INECTESSCFNGGTCVDGINSFSCLCPVGF----TGSFCLHEINECSSHP-----CLNEG 1038

Query: 1225 RCVNTSGSFRCVCKAGF 1241
             CV+  G++RC C  G+
Sbjct: 1039 TCVDGLGTYRCSCPLGY 1055



 Score =  188 bits (478), Expect = 2e-47
 Identities = 194/727 (26%), Positives = 274/727 (37%), Gaps = 174/727 (23%)

Query: 571  QVTETDECRLNQNICGHGECVPGPPD-YSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629
            Q + +  C +++     G C     D Y C C  G+      + C   + C + PC  G 
Sbjct: 102  QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTG----KECQWTDACLSHPCANG- 156

Query: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCY 688
              C      ++C C  G+       G+ C  D+NEC  P  C  GG C+N PG Y+C C 
Sbjct: 157  STCTTVANQFSCKCLTGFT------GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCP 210

Query: 689  PGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG--SFKCIACQPGYRSQGGGACRDVN 746
             G+         C+ +     PS C +G    + G  +F+C  C PG+  +G    R+++
Sbjct: 211  QGF-----TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFEC-NCLPGF--EGSTCERNID 262

Query: 747  ECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL-DVDEC-EAGDVCDN-GICSNT 803
            +C      + G C +   ++ C C     P   G+ C  DVDEC    + C N G C+N 
Sbjct: 263  DCPNHRCQNGGVCVDGVNTYNCRC----PPQWTGQFCTEDVDECLLQPNACQNGGTCANR 318

Query: 804  PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK 863
             G + C C++G+  S D    E+ID+C F +   G  CI+   S+ C+CP+G     G  
Sbjct: 319  NGGYGCVCVNGW--SGD-DCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGK---AGLL 372

Query: 864  CQDIDECSQDPSLCLPHGACKN--LQGSYVCVCDEGF-----TPTQDQHGCEEVEQPHHK 916
            C   D C  +P  C     C    L G Y+C C +G+     T   D+          H 
Sbjct: 373  CHLDDACISNP--CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHA 430

Query: 917  KECYLNFDDTVFC-------------------------DSVLATNVTQQECCCSLGAGWG 951
             +C +N D    C                         D+     +    C C  G   G
Sbjct: 431  GKC-VNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFK-G 488

Query: 952  DHCEI-------YPCP-----VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999
             HCE+        PC      V     F  LCP   G+T        G     DID+C  
Sbjct: 489  VHCELEINECQSNPCVNNGQCVDKVNRFQCLCP--PGFT--------GPVCQIDIDDC-- 536

Query: 1000 FGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGY 1058
              S  C  G KC++   GYEC C  GF   G L E  ++D C D   C +G C++    Y
Sbjct: 537  -SSTPCLNGAKCIDHPNGYECQCATGF--TGVLCE-ENIDNC-DPDPCHHGQCQDGIDSY 591

Query: 1059 RCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRG-EDGMCAGPLAGPALTFDDCCC 1117
             C C P   Y  A              ++ D C+S     DG C   +            
Sbjct: 592  TCICNP--GYMGA-----------ICSDQIDECYSSPCLNDGRCIDLVN----------- 627

Query: 1118 RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-- 1175
                  G QC  C P  +G +C                            E + D+C   
Sbjct: 628  ------GYQCN-CQPGTSGVNC----------------------------EINFDDCASN 652

Query: 1176 -CVSGRCVPRPGGAVCECPGGFQLDASRARC-VDIDECRELNQRGLLCKSERCVNTSGSF 1233
             C+ G C+       C C  GF    +  RC +DIDEC     R    K   C+N    F
Sbjct: 653  PCIHGICMDGINRYSCVCSPGF----TGQRCNIDIDECASNPCR----KGATCINGVNGF 704

Query: 1234 RCVCKAG 1240
            RC+C  G
Sbjct: 705  RCICPEG 711



 Score =  177 bits (450), Expect = 4e-44
 Identities = 190/714 (26%), Positives = 259/714 (36%), Gaps = 120/714 (16%)

Query: 586  GHGECVPGPPDYSCHCNPGYRSHPQH---RYCVDVNECEAEPCGPGRGICMNTG--GSYN 640
            G+  CV      + H   GY   P+     YC   + CE   C  G G C+     G   
Sbjct: 31   GYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNG-GTCVAQAMLGKAT 89

Query: 641  CHCNRGYRLHVGAGGRSCV--DLNECAKPHLCGDGGFCINFPGH-YKCNCYPGYRLKASR 697
            C C  G+       G  C     + C     C +GG C       Y+C C  G+  K   
Sbjct: 90   CRCASGFT------GEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE-- 141

Query: 698  PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVNECAEGSPCSP 756
               C+  D C          C      F C  C  G+  Q    C  DVNEC     C  
Sbjct: 142  ---CQWTDACLSHPCANGSTCTTVANQFSC-KCLTGFTGQ---KCETDVNECDIPGHCQH 194

Query: 757  GW-CENLPGSFRCTCAQGYAPAPDGRSCLDVD-ECEAGDVCDNGICSNTPG-SFQCQCLS 813
            G  C NLPGS++C C QG+     G+ C  +   C      + G C  T   +F+C CL 
Sbjct: 195  GGTCLNLPGSYQCQCPQGFT----GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 250

Query: 814  GYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQ 872
            G+    + S CE +ID+C       GG C++   +Y C CP   +  G    +D+DEC  
Sbjct: 251  GF----EGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPP--QWTGQFCTEDVDECLL 304

Query: 873  DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCD-- 930
             P+ C   G C N  G Y CVC  G++                  +C  N DD  F    
Sbjct: 305  QPNACQNGGTCANRNGGYGCVCVNGWSGD----------------DCSENIDDCAFASCT 348

Query: 931  --SVLATNVTQQECCCSLGAGW-----GDHCEIYPCPVYSSAEFHSL-----CPDGKGYT 978
              S     V    C C  G         D C   PC   +  + + L     C   +GY 
Sbjct: 349  PGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK 408

Query: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQPGYECYCKQGFYYDGNLLECVDV 1037
                    G     D+DEC +  S  C+  GKCVNT   + C C +G  Y G   E +D+
Sbjct: 409  --------GADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKG--YAGPRCE-MDI 457

Query: 1038 DECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAP-ERRDVCWSQRG 1096
            +EC  +    +  C +  GG+ C C P  +    +   L   E +  P      C  +  
Sbjct: 458  NECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCE---LEINECQSNPCVNNGQCVDKVN 514

Query: 1097 E-DGMCAGPLAGPALTFD-DCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS-----ESNSF 1149
                +C     GP    D D C       GA+C    P G    C T  +     E+   
Sbjct: 515  RFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCID-HPNGYECQCATGFTGVLCEENIDN 573

Query: 1150 WDTSPLLLGKPPRDEDS-------------SEEDSDECR---CVS-GRCVPRPGGAVCEC 1192
             D  P   G+     DS               +  DEC    C++ GRC+    G  C C
Sbjct: 574  CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNC 633

Query: 1193 PGGFQLDASRARC-VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSR 1245
              G     S   C ++ D+C         C    C++    + CVC  GF   R
Sbjct: 634  QPG----TSGVNCEINFDDCASNP-----CIHGICMDGINRYSCVCSPGFTGQR 678



 Score =  165 bits (418), Expect = 2e-40
 Identities = 218/882 (24%), Positives = 319/882 (36%), Gaps = 197/882 (22%)

Query: 355  DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH 413
            DI+ECA    CR G  C+N    +RC+CP G    P    C +   E  S         +
Sbjct: 682  DIDECAS-NPCRKGATCINGVNGFRCICPEG----PHHPSCYSQVNECLS---------N 727

Query: 414  QCQHP-LTTRLTRQLCCCSVGKAW-GARCQ---------RCPTDGTA-----AFKEICPA 457
             C H   T  L+   C C  G  W G  C+          C   GT       ++  C  
Sbjct: 728  PCIHGNCTGGLSGYKCLCDAG--WVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKK 785

Query: 458  G-KGYHILTS----------HQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDT 506
            G KGY+   +          +Q       S ++         K  Q   +P    P E+ 
Sbjct: 786  GFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENA 845

Query: 507  EEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPP------TMRWFLPDLPP 560
                 V  +SP  E  +   +             E IS+P         T   ++ + PP
Sbjct: 846  ----AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPP 901

Query: 561  SRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC 620
              S ++       + D+C  N    G G C+ G   +SC C PG+      +   D+NEC
Sbjct: 902  GFSGMDCEE----DIDDCLANPCQNG-GSCMDGVNTFSCLCLPGFTGD---KCQTDMNEC 953

Query: 621  EAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD-LNECAKPHLCGDGGFCINF 679
             +EPC  G G C +   SY C C  G+       G  C + +NEC +   C +GG C++ 
Sbjct: 954  LSEPCKNG-GTCSDYVNSYTCKCQAGF------DGVHCENNINECTESS-CFNGGTCVDG 1005

Query: 680  PGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG- 738
               + C C  G+    +      +I+EC       +G C +  G+++C +C  GY  +  
Sbjct: 1006 INSFSCLCPVGF----TGSFCLHEINECSSHPCLNEGTCVDGLGTYRC-SCPLGYTGKNC 1060

Query: 739  --------GGACRDVNECAEGSP-----CSPGW--------------------------- 758
                       C++   C +        C  GW                           
Sbjct: 1061 QTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLC 1120

Query: 759  -----CENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGI-CSNTPGSFQCQC 811
                 C N   +  C C  GY     G  C + +DEC A + C +G  CS+  G ++C+C
Sbjct: 1121 QHSGVCINAGNTHYCQCPLGYT----GSYCEEQLDEC-ASNPCQHGATCSDFIGGYRCEC 1175

Query: 812  LSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQD-IDE 869
            + GY       +CE ++DEC       GG CI+    ++C CP G R   G  C++ ID+
Sbjct: 1176 VPGYQ----GVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTR---GLLCEENIDD 1228

Query: 870  CSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFC 929
            C++ P  CL  G C +  G Y C C  GF   +    CE         EC  N   +   
Sbjct: 1229 CARGPH-CLNGGQCMDRIGGYSCRCLPGFAGER----CEG-----DINECLSNPCSSE-- 1276

Query: 930  DSVLATNVTQQECCCSLGAGWGDHCEIY-------PCPVYSSAEFHSLCPDGKGYTQDNN 982
             S+    +T    C    A  G HCE +       PC    +    S  PDG        
Sbjct: 1277 GSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPP- 1335

Query: 983  IVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQGFYYDGNLLECVDVDECL 1041
                G    R    C   G   C++G+ CV+T  G  C+C        +  +C       
Sbjct: 1336 ----GFSGARCQSSC---GQVKCRKGEQCVHTASGPRCFCP-------SPRDC------- 1374

Query: 1042 DESNCRNGVCENTRGG----------YRCACTPPAEYSPAQRQCLSPEEMERAPERRDVC 1091
             ES C +  C++  GG          Y C C PP   S  +    +P     A      C
Sbjct: 1375 -ESGCASSPCQH--GGSCHPQRQPPYYSCQCAPPFSGSRCELY-TAPPSTPPATCLSQYC 1430

Query: 1092 WSQRGEDGMCAGPLAGPALTFD--DCCCRQGRGWGAQCRPCP 1131
             + +  DG+C       A  +D  DC       W     P P
Sbjct: 1431 -ADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLP 1471



 Score =  131 bits (329), Expect = 5e-30
 Identities = 119/417 (28%), Positives = 176/417 (42%), Gaps = 72/417 (17%)

Query: 580  LNQNICGH-GECVPGPPDYSCHCNPGYRSHPQHRYCVD-VNECEAEPCGPGRGICMNTGG 637
            L +++C H G C+     + C C  GY       YC + ++EC + PC  G   C +  G
Sbjct: 1115 LVEHLCQHSGVCINAGNTHYCQCPLGYTGS----YCEEQLDECASNPCQHG-ATCSDFIG 1169

Query: 638  SYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
             Y C C  GY+      G +C  +++EC     C +GG CI+   H+KC+C PG     +
Sbjct: 1170 GYRCECVPGYQ------GVNCEYEVDECQNQP-CQNGGTCIDLVNHFKCSCPPG-----T 1217

Query: 697  RPPVCED-IDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACR-DVNECAEGSP 753
            R  +CE+ ID+C R P     G+C ++ G + C  C PG+    G  C  D+NEC   +P
Sbjct: 1218 RGLLCEENIDDCARGPHCLNGGQCMDRIGGYSC-RCLPGF---AGERCEGDINECLS-NP 1272

Query: 754  CSPGW---CENLPGSFRCTCAQGYAPAPDGRSCLD-VDECEAGDVCDNGIC---SNTPGS 806
            CS      C  L   + C C   +     GR C   VD C      + G C   SN P  
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFT----GRHCETFVDVCPQMPCLNGGTCAVASNMPDG 1328

Query: 807  FQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQD 866
            F C+C  G+  +R +S C  + +C       G  C++T    RC CP        R C+ 
Sbjct: 1329 FICRCPPGFSGARCQSSCGQV-KCR-----KGEQCVHTASGPRCFCP------SPRDCE- 1375

Query: 867  IDECSQDPSLCLPHGAC--KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH-------KK 917
               C+  P  C   G+C  +     Y C C   F+ ++    CE    P          +
Sbjct: 1376 -SGCASSP--CQHGGSCHPQRQPPYYSCQCAPPFSGSR----CELYTAPPSTPPATCLSQ 1428

Query: 918  ECYLNFDDTVFCDSVLATNVTQ---QECCCSLGAGWGDHCEIYPCPVYSSAEFHSLC 971
             C     D V CD    ++  Q    +C  ++   W +     PC  Y + +   LC
Sbjct: 1429 YCADKARDGV-CDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELC 1484



 Score =  101 bits (252), Expect = 4e-21
 Identities = 132/522 (25%), Positives = 187/522 (35%), Gaps = 119/522 (22%)

Query: 747  ECAEG-SPC-SPGWCENLP-GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNT 803
            +C +G  PC + G C     G+  C C +G+     G  C   D CE     + G C   
Sbjct: 27   QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFL----GEYCQHRDPCEKNRCQNGGTCVAQ 82

Query: 804  P--GSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GGDC-INTNGSYRCLCPQGHRLV 859
               G   C+C SG+  + +         C     C+ GG C + +  +Y C C  G    
Sbjct: 83   AMLGKATCRCASGF--TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT-- 138

Query: 860  GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE- 918
             G++CQ  D C   P  C     C  +   + C C  GFT  + +    E + P H +  
Sbjct: 139  -GKECQWTDACLSHP--CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG 195

Query: 919  -CYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHS-LCPDGKG 976
               LN   +              +C C  G   G +C+    P   S   +   C     
Sbjct: 196  GTCLNLPGSY-------------QCQCPQGFT-GQYCDSLYVPCAPSPCVNGGTCRQTGD 241

Query: 977  YTQDNNIVN--YGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQGFYYDGNLLE 1033
            +T + N +    G    R+ID+C    +  C+ G  CV+    Y C C     + G    
Sbjct: 242  FTFECNCLPGFEGSTCERNIDDCP---NHRCQNGGVCVDGVNTYNCRCPP--QWTGQFCT 296

Query: 1034 CVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVC 1091
              DVDECL + N C+NG  C N  GGY C C                             
Sbjct: 297  -EDVDECLLQPNACQNGGTCANRNGGYGCVCVNG-------------------------- 329

Query: 1092 WSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP---CPPRGAGSHCPTSQSESNS 1148
            WS  G+D  C+  +       DDC         A C P   C  R A   C   + ++  
Sbjct: 330  WS--GDD--CSENI-------DDCAF-------ASCTPGSTCIDRVASFSCMCPEGKAGL 371

Query: 1149 FWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCV---PRPGGAVCECPGGFQLDASRARC 1205
                    +  P               C  G      P  G  +C CP G++     A C
Sbjct: 372  LCHLDDACISNP---------------CHKGALCDTNPLNGQYICTCPQGYK----GADC 412

Query: 1206 V-DIDECRELNQRGLLCK-SERCVNTSGSFRCVCKAGFARSR 1245
              D+DEC   N     C+ + +CVNT G+F C C  G+A  R
Sbjct: 413  TEDVDECAMANSNP--CEHAGKCVNTDGAFHCECLKGYAGPR 452



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 20/31 (64%), Positives = 24/31 (77%), Gaps = 1/31 (3%)

Query: 355 DINECAMPGVCRHGD-CLNNPGSYRCVCPPG 384
           D+NEC +PG C+HG  CLN PGSY+C CP G
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQG 212



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 10/81 (12%)

Query: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAM--PGVCRH-GDCLNNPGSYRCVCPPGHSLG 388
           P+ G+    CPQGYK  + T  +D++ECAM     C H G C+N  G++ C C  G++ G
Sbjct: 394 PLNGQYICTCPQGYKGADCT--EDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA-G 450

Query: 389 P----SRTQCIADKPEEKSLC 405
           P       +C +D  +  + C
Sbjct: 451 PRCEMDINECHSDPCQNDATC 471



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 33/89 (37%), Positives = 40/89 (44%), Gaps = 22/89 (24%)

Query: 75  CLKGQCRDSCQQGSN----------MTLIGENGHSTDTLTGSGFRVVVCPL--------P 116
           CLKG     C+   N           T + + G  T  L   GF+ V C L        P
Sbjct: 444 CLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFT-CLCMPGFKGVHCELEINECQSNP 502

Query: 117 CMNGGQCS---SRNQCLCPPDFTGRFCQV 142
           C+N GQC    +R QCLCPP FTG  CQ+
Sbjct: 503 CVNNGQCVDKVNRFQCLCPPGFTGPVCQI 531



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 16/79 (20%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGH------------SLG 388
            CP G+      H  +INEC+       G C++  G+YRC CP G+            S  
Sbjct: 1013 CPVGFTGSFCLH--EINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRS 1070

Query: 389  PSRTQ--CIADKPEEKSLC 405
            P + +  C+  K E + LC
Sbjct: 1071 PCKNKGTCVQKKAESQCLC 1089



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 7/43 (16%)

Query: 110  VVVCP-LPCMNGGQCSSRNQ------CLCPPDFTGRFCQVPAG 145
            V VCP +PC+NGG C+  +       C CPP F+G  CQ   G
Sbjct: 1305 VDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCG 1347



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 5/50 (10%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGP 389
           C  G+K     HC+ +INEC       +G C++    ++C+CPPG + GP
Sbjct: 482 CMPGFK---GVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFT-GP 527



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 36/126 (28%), Positives = 49/126 (38%), Gaps = 33/126 (26%)

Query: 354 QDINECAM-PGVCRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP 411
           +D++EC + P  C++G  C N  G Y CVC  G S G   ++ I D        F   +P
Sbjct: 297 EDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWS-GDDCSENIDD------CAFASCTP 349

Query: 412 EHQCQHPLTTRLTRQLCCCSVGKAW----------------GARCQRCPTDGTAAFKEIC 455
              C      R+    C C  GKA                 GA C   P +G    + IC
Sbjct: 350 GSTC----IDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNG----QYIC 401

Query: 456 PAGKGY 461
              +GY
Sbjct: 402 TCPQGY 407



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 29/131 (22%), Positives = 55/131 (41%), Gaps = 12/131 (9%)

Query: 334  RGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT- 392
            +G    +CP G+  ++    +DI++C        G C++   ++ C+C PG +    +T 
Sbjct: 892  QGSYMCECPPGFSGMDCE--EDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTD 949

Query: 393  --QCIADKPEEKSLCFRLV-SPEHQCQHPLT-TRLTRQLCCCSVGKAW-GARCQRCPTDG 447
              +C+++  +    C   V S   +CQ           +  C+    + G  C     DG
Sbjct: 950  MNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTC----VDG 1005

Query: 448  TAAFKEICPAG 458
              +F  +CP G
Sbjct: 1006 INSFSCLCPVG 1016



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 17/81 (20%)

Query: 68   PVICKRTCLKG--QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQC-- 123
            P + + TC+ G    R SC        +G  G +  TL     R      PC N G C  
Sbjct: 1033 PCLNEGTCVDGLGTYRCSCP-------LGYTGKNCQTLVNLCSRS-----PCKNKGTCVQ 1080

Query: 124  -SSRNQCLCPPDFTGRFCQVP 143
              + +QCLCP  + G +C VP
Sbjct: 1081 KKAESQCLCPSGWAGAYCDVP 1101



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 29/84 (34%), Positives = 38/84 (45%), Gaps = 17/84 (20%)

Query: 84  CQQGSNMTLIGENGHSTDTLTG-SGFR----VVVCPLP--CMNGGQCSS---RNQCLCPP 133
           C  GS  T +  N  S   LTG +G +    V  C +P  C +GG C +     QC CP 
Sbjct: 153 CANGSTCTTVA-NQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQ 211

Query: 134 DFTGRFCQ------VPAGGAGGGT 151
            FTG++C        P+    GGT
Sbjct: 212 GFTGQYCDSLYVPCAPSPCVNGGT 235



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 8/56 (14%)

Query: 338 GADC---PQGYKRLNSTH-----CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGH 385
           GA C   P GY+   +T      C++  +   P  C HG C +   SY C+C PG+
Sbjct: 544 GAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGY 599



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 6/47 (12%)

Query: 341  CPQGYKRLNSTHCQD-INECAMPGVCRHG-DCLNNPGSYRCVCPPGH 385
            CP GY     ++C++ ++ECA    C+HG  C +  G YRC C PG+
Sbjct: 1137 CPLGY---TGSYCEEQLDECAS-NPCQHGATCSDFIGGYRCECVPGY 1179



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 34/137 (24%), Positives = 50/137 (36%), Gaps = 38/137 (27%)

Query: 341  CPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399
            C  G+   +  HC++ INEC        G C++   S+ C+CP G +             
Sbjct: 975  CQAGF---DGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFT------------- 1018

Query: 400  EEKSLCFRLVS--PEHQCQHPLT--TRLTRQLCCCSVGKAWGARCQR---------CPTD 446
               S C   ++    H C +  T    L    C C +G   G  CQ          C   
Sbjct: 1019 --GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYT-GKNCQTLVNLCSRSPCKNK 1075

Query: 447  GTAAFKE-----ICPAG 458
            GT   K+     +CP+G
Sbjct: 1076 GTCVQKKAESQCLCPSG 1092



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 29/86 (33%), Positives = 32/86 (37%), Gaps = 20/86 (23%)

Query: 75   CLKGQCRDSCQQGSNMTLIG--ENGHSTDTLTGS-------GFRVVVCP--------LPC 117
            CL G   D CQ   N  L    +NG +      S       GF  V C           C
Sbjct: 937  CLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSC 996

Query: 118  MNGGQCS---SRNQCLCPPDFTGRFC 140
             NGG C    +   CLCP  FTG FC
Sbjct: 997  FNGGTCVDGINSFSCLCPVGFTGSFC 1022



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 5/65 (7%)

Query: 116  PCMNGGQC---SSRNQCLCPPDFTGRFCQVPAGGAGGGTG--GSGPGLSRTGALSTGALP 170
            PC NGG C    +  +C CPP   G  C+        G      G  + R G  S   LP
Sbjct: 1195 PCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLP 1254

Query: 171  PLAPE 175
              A E
Sbjct: 1255 GFAGE 1259



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 15/29 (51%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCS---SRNQCLCPPDFTGRFCQ 141
           PC NGG C    +   CLC P FTG  CQ
Sbjct: 919 PCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 14/50 (28%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 335  GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
            G    +C  GY+ +N  +  +++EC        G C++    ++C CPPG
Sbjct: 1169 GGYRCECVPGYQGVNCEY--EVDECQNQPCQNGGTCIDLVNHFKCSCPPG 1216



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 3/27 (11%)

Query: 117 CMNGGQCS---SRNQCLCPPDFTGRFC 140
           C NGG C    +   C CPP +TG+FC
Sbjct: 269 CQNGGVCVDGVNTYNCRCPPQWTGQFC 295



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 18/74 (24%)

Query: 74  TCLK--GQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRN---- 127
           TCL   G  +  C QG         G   D+L      V   P PC+NGG C        
Sbjct: 197 TCLNLPGSYQCQCPQGFT-------GQYCDSLY-----VPCAPSPCVNGGTCRQTGDFTF 244

Query: 128 QCLCPPDFTGRFCQ 141
           +C C P F G  C+
Sbjct: 245 ECNCLPGFEGSTCE 258



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 15/30 (50%), Positives = 19/30 (63%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQCS--SRN--QCLCPPDFTGRFCQ 141
           PC+NGG C   SR+  +C C   FTG+ CQ
Sbjct: 114 PCLNGGTCHMLSRDTYECTCQVGFTGKECQ 143



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 32/127 (25%), Positives = 47/127 (37%), Gaps = 19/127 (14%)

Query: 341 CPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC----- 394
           C  GY       C D I+EC        G C++    Y+C C P    G S   C     
Sbjct: 595 CNPGYM---GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP----GTSGVNCEINFD 647

Query: 395 -IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT--DGTAAF 451
             A  P    +C   ++  + C    +   T Q C   + +     C++  T  +G   F
Sbjct: 648 DCASNPCIHGICMDGIN-RYSC--VCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGF 704

Query: 452 KEICPAG 458
           + ICP G
Sbjct: 705 RCICPEG 711



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 13/29 (44%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 116 PCMNGGQCSSRN---QCLCPPDFTGRFCQ 141
           PCMN G C +      C CPP F+G  C+
Sbjct: 881 PCMNHGLCHNTQGSYMCECPPGFSGMDCE 909



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 13/28 (46%), Positives = 15/28 (53%), Gaps = 3/28 (10%)

Query: 117  CMNGGQCSSR---NQCLCPPDFTGRFCQ 141
            C+NGGQC  R     C C P F G  C+
Sbjct: 1235 CLNGGQCMDRIGGYSCRCLPGFAGERCE 1262



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 12/30 (40%), Positives = 15/30 (50%), Gaps = 4/30 (13%)

Query: 116 PCMNGGQC----SSRNQCLCPPDFTGRFCQ 141
           PC+N G C    +    C CP  F G +CQ
Sbjct: 34  PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ 63



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 18/73 (24%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS--LGPSRT 392
           G  G  C  G+   + +  ++I++CA         C++   S+ C+CP G +  L     
Sbjct: 320 GGYGCVCVNGWSGDDCS--ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDD 377

Query: 393 QCIADKPEEKSLC 405
            CI++   + +LC
Sbjct: 378 ACISNPCHKGALC 390



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 14/45 (31%), Positives = 21/45 (46%), Gaps = 4/45 (8%)

Query: 341 CPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
           CP G+       CQ DI++C+         C+++P  Y C C  G
Sbjct: 520 CPPGF---TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATG 561



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 3/45 (6%)

Query: 341  CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPG 384
            CP G + L     ++I++CA    C +G  C++  G Y C C PG
Sbjct: 1213 CPPGTRGLLCE--ENIDDCARGPHCLNGGQCMDRIGGYSCRCLPG 1255



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 5/32 (15%)

Query: 116  PCMNGGQCSSRNQ-----CLCPPDFTGRFCQV 142
            PC +GG C  + Q     C C P F+G  C++
Sbjct: 1382 PCQHGGSCHPQRQPPYYSCQCAPPFSGSRCEL 1413


>gi|190343004 EGF-containing fibulin-like extracellular matrix
           protein 2 [Homo sapiens]
          Length = 443

 Score =  190 bits (482), Expect = 8e-48
 Identities = 115/302 (38%), Positives = 144/302 (47%), Gaps = 27/302 (8%)

Query: 595 PDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNCHCNRGYRLHVGA 653
           PD    C  GY   P  ++C DVNEC   P    G   C+N  G Y C            
Sbjct: 33  PDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------- 81

Query: 654 GGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDP-SS 712
             RS   +N+     L G+G      P  +   C PGY  +      C D+DEC      
Sbjct: 82  -PRSAAVIND-----LHGEGPPPPVPPAQHPNPCPPGY--EPDDQDSCVDVDECAQALHD 133

Query: 713 C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA 771
           C P   C N PGS++C  C  GYR  G   C D++EC     C    C NLPGSFRC C 
Sbjct: 134 CRPSQDCHNLPGSYQC-TCPDGYRKIGP-ECVDIDECRYRY-CQHR-CVNLPGSFRCQCE 189

Query: 772 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD 831
            G+   P+ RSC+DV+EC+ G  C+   C N+ G+F C+C  GY L RD   C DIDEC 
Sbjct: 190 PGFQLGPNNRSCVDVNECDMGAPCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECS 248

Query: 832 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
           + +      C+N  G + C CPQG++L+  R CQDIDEC      C     C N  G Y 
Sbjct: 249 YSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308

Query: 892 CV 893
           CV
Sbjct: 309 CV 310



 Score =  132 bits (331), Expect = 3e-30
 Identities = 87/271 (32%), Positives = 123/271 (45%), Gaps = 46/271 (16%)

Query: 482 LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
           LH +GPP P    + P+  PP  + +++     DS V  +   Q  H    +      P 
Sbjct: 91  LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-----DSCVDVDECAQALHDCRPSQDCHNLPG 145

Query: 542 LISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHC 601
                 P   R             +I P +  + DECR     C H  CV  P  + C C
Sbjct: 146 SYQCTCPDGYR-------------KIGP-ECVDIDECRYRY--CQH-RCVNLPGSFRCQC 188

Query: 602 NPGYRSHPQHRYCVDVNECE-AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            PG++  P +R CVDVNEC+   PC      C N+ G++ C C++GY LH    G SC D
Sbjct: 189 EPGFQLGPNNRSCVDVNECDMGAPC---EQRCFNSYGTFLCRCHQGYELH--RDGFSCSD 243

Query: 661 LNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
           ++EC+   +LC     C+N PG + C+C  GY+L A+R  +C+DIDEC            
Sbjct: 244 IDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQLLATR--LCQDIDEC------------ 287

Query: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAE 750
            + G+ +C   Q      GG  C D N C E
Sbjct: 288 -ESGAHQCSEAQTCVNFHGGYRCVDTNRCVE 317



 Score =  106 bits (265), Expect = 1e-22
 Identities = 90/324 (27%), Positives = 129/324 (39%), Gaps = 69/324 (21%)

Query: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRCL------- 851
            S  P S+  +C  GY    D  HC D++EC   P AC G   CIN  G Y CL       
Sbjct: 30   SEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVI 88

Query: 852  --------------------CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
                                CP G+       C D+DEC+Q    C P   C NL GSY 
Sbjct: 89   NDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148

Query: 892  CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG 951
            C C +G+     +  C ++++  ++           +C            C C  G   G
Sbjct: 149  CTCPDGYRKIGPE--CVDIDECRYR-----------YCQHRCVNLPGSFRCQCEPGFQLG 195

Query: 952  DH----CEIYPCPVYSSAE---FHS----LCPDGKGYTQDNNIVNYGIPAHRDIDECMLF 1000
             +     ++  C + +  E   F+S    LC   +GY    +  +       DIDEC  +
Sbjct: 196  PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCS-----DIDECS-Y 249

Query: 1001 GSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNG-VCENTRGGY 1058
             S +C + +CVN    + C+C QG+      L C D+DEC   ++ C     C N  GGY
Sbjct: 250  SSYLC-QYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGY 307

Query: 1059 RCA----CTPPAEYSPAQRQCLSP 1078
            RC     C  P     ++ +CL P
Sbjct: 308  RCVDTNRCVEP-YIQVSENRCLCP 330



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 78/283 (27%), Positives = 104/283 (36%), Gaps = 72/283 (25%)

Query: 958  PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017
            P P    A+  + CP G      ++ V        D+DEC     +      C N    Y
Sbjct: 96   PPPPVPPAQHPNPCPPGYEPDDQDSCV--------DVDECAQALHDCRPSQDCHNLPGSY 147

Query: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
            +C C  G+   G   ECVD+DEC     C++  C N  G +RC C P  +  P  R C+ 
Sbjct: 148  QCTCPDGYRKIGP--ECVDIDECRYRY-CQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVD 203

Query: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS 1137
              E +        C++  G              TF  C C QG                 
Sbjct: 204  VNECDMGAPCEQRCFNSYG--------------TF-LCRCHQG----------------- 231

Query: 1138 HCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVS----GRCVPRPGGAVCECP 1193
                 +   + F                 S  D DEC   S     RCV  PG   C CP
Sbjct: 232  ----YELHRDGF-----------------SCSDIDECSYSSYLCQYRCVNEPGRFSCHCP 270

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
             G+QL A+R  C DIDEC     +    +++ CVN  G +RCV
Sbjct: 271  QGYQLLATRL-CQDIDECESGAHQ--CSEAQTCVNFHGGYRCV 310



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 73/255 (28%), Positives = 91/255 (35%), Gaps = 63/255 (24%)

Query: 1014 QPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV--CENTRGGYRCACT-------- 1063
            +P     C  G+ +D +   C DV+ECL       G   C N  GGY C           
Sbjct: 32   EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91

Query: 1064 ----PPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
                PP    PAQ     P   E  P+ +D C     +   CA  L        DC    
Sbjct: 92   HGEGPPPPVPPAQHPNPCPPGYE--PDDQDSCV----DVDECAQALHD-CRPSQDCHNLP 144

Query: 1120 GRGWGAQCRPCPP--RGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC- 1176
            G     QC  CP   R  G  C                              D DECR  
Sbjct: 145  G---SYQCT-CPDGYRKIGPECV-----------------------------DIDECRYR 171

Query: 1177 -VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1235
                RCV  PG   C+C  GFQL  +   CVD++EC      G  C+ +RC N+ G+F C
Sbjct: 172  YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC----DMGAPCE-QRCFNSYGTFLC 226

Query: 1236 VCKAGFARSRPHGAC 1250
             C  G+   R   +C
Sbjct: 227  RCHQGYELHRDGFSC 241



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 77/302 (25%), Positives = 99/302 (32%), Gaps = 98/302 (32%)

Query: 971  CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK-EGKCVNTQPGYECY--------- 1020
            C DG  +  D+          RD++EC+    E CK E KC+N   GY C          
Sbjct: 39   CTDGYEWDPDSQHC-------RDVNECLTI-PEACKGEMKCINHYGGYLCLPRSAAVIND 90

Query: 1021 ------------------CKQGFYYDGNLLECVDVDECLDE-SNCRNGV-CENTRGGYRC 1060
                              C  G+  D     CVDVDEC     +CR    C N  G Y+C
Sbjct: 91   LHGEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQC 149

Query: 1061 ACTPPAEYSPAQRQCLSPEEME-RAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
             C  P  Y     +C+  +E   R  + R  C +  G                  C C  
Sbjct: 150  TC--PDGYRKIGPECVDIDECRYRYCQHR--CVNLPGSFR---------------CQCEP 190

Query: 1120 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1179
            G   G   R C                    D +   +G P                   
Sbjct: 191  GFQLGPNNRSCV-------------------DVNECDMGAPCEQ---------------- 215

Query: 1180 RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKA 1239
            RC    G  +C C  G++L      C DIDEC   +    LC+  RCVN  G F C C  
Sbjct: 216  RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLCQ-YRCVNEPGRFSCHCPQ 271

Query: 1240 GF 1241
            G+
Sbjct: 272  GY 273



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 61/198 (30%), Positives = 73/198 (36%), Gaps = 42/198 (21%)

Query: 1062 CTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGP--ALTFDDCCCRQ 1119
            CT   E+ P  + C    E    PE    C  +        G L  P  A   +D     
Sbjct: 39   CTDGYEWDPDSQHCRDVNECLTIPE---ACKGEMKCINHYGGYLCLPRSAAVINDL---H 92

Query: 1120 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1179
            G G      P PP    + CP                 G  P D+DS   D DEC     
Sbjct: 93   GEG---PPPPVPPAQHPNPCPP----------------GYEPDDQDSCV-DVDECAQALH 132

Query: 1180 RCVPR------PGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1233
             C P       PG   C CP G++       CVDIDECR        C+  RCVN  GSF
Sbjct: 133  DCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECRYR-----YCQ-HRCVNLPGSF 184

Query: 1234 RCVCKAGFARSRPHGACV 1251
            RC C+ GF     + +CV
Sbjct: 185  RCQCEPGFQLGPNNRSCV 202



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 39/135 (28%), Positives = 52/135 (38%), Gaps = 32/135 (23%)

Query: 265 PSHPRPPTQKPLGRCFQDTLPKQPCGSNPLP----GLTKQEDCCGSIGTAWGQSKCHKCP 320
           P  P PP Q P            PC     P         ++C  ++        CH  P
Sbjct: 96  PPPPVPPAQHP-----------NPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLP 144

Query: 321 QLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCV 380
                         G     CP GY+++    C DI+EC     C+H  C+N PGS+RC 
Sbjct: 145 --------------GSYQCTCPDGYRKIGP-ECVDIDECRYR-YCQHR-CVNLPGSFRCQ 187

Query: 381 CPPGHSLGPSRTQCI 395
           C PG  LGP+   C+
Sbjct: 188 CEPGFQLGPNNRSCV 202



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 56/206 (27%), Positives = 76/206 (36%), Gaps = 24/206 (11%)

Query: 255 PSQHLLPHPKPSHPRPPTQKP---LGRCFQ---DTLPKQPCGSNPLPGLTKQEDCCGSIG 308
           P+QH  P+P P    P  Q     +  C Q   D  P Q C + P        D    IG
Sbjct: 102 PAQH--PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIG 159

Query: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKR-LNSTHCQDINECAMPGVCRH 367
                    +    Q+  V  PG  R      C  G++   N+  C D+NEC M   C  
Sbjct: 160 PECVDIDECRYRYCQHRCVNLPGSFR----CQCEPGFQLGPNNRSCVDVNECDMGAPCEQ 215

Query: 368 GDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLC-FRLVSP--EHQCQHP---- 418
             C N+ G++ C C  G+ L      C  I +      LC +R V+      C  P    
Sbjct: 216 -RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274

Query: 419 -LTTRLTRQLCCCSVGKAWGARCQRC 443
            L TRL + +  C  G    +  Q C
Sbjct: 275 LLATRLCQDIDECESGAHQCSEAQTC 300



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 30/84 (35%), Positives = 37/84 (44%), Gaps = 11/84 (13%)

Query: 323 QYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV 380
           QY  V +PG         CPQGY+ L +  CQDI+EC      C     C+N  G YRCV
Sbjct: 255 QYRCVNEPG----RFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310

Query: 381 -----CPPGHSLGPSRTQCIADKP 399
                  P   +  +R  C A  P
Sbjct: 311 DTNRCVEPYIQVSENRCLCPASNP 334



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 22/115 (19%)

Query: 1139 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1198
            C +    S   W    LLLG     +DS E DS                   EC  G++ 
Sbjct: 4    CASCLPGSLLLWALLLLLLGSAS-PQDSEEPDS-----------------YTECTDGYEW 45

Query: 1199 DASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKAGFARSRPHGACVP 1252
            D     C D++EC  + +    CK E +C+N  G + C+ ++    +  HG   P
Sbjct: 46   DPDSQHCRDVNECLTIPE---ACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 3/44 (6%)

Query: 340 DCPQGYK-RLNSTHCQDINEC-AMPGVCR-HGDCLNNPGSYRCV 380
           +C  GY+   +S HC+D+NEC  +P  C+    C+N+ G Y C+
Sbjct: 38  ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL 81


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  187 bits (476), Expect = 4e-47
 Identities = 116/369 (31%), Positives = 164/369 (44%), Gaps = 56/369 (15%)

Query: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
           + DEC    + C     C   P  Y C C  GY    +H  C DV+ECE E        C
Sbjct: 29  DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVHDC 86

Query: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGF---CINFPGHYKCNCYP 689
           +N  G+Y C C  G+  H+   G +C+D++ECA+    G+GG    C+N  G Y+C+C  
Sbjct: 87  VNIPGNYRCTCYDGF--HLAHDGHNCLDVDECAE----GNGGCQQSCVNMMGSYECHCRE 140

Query: 690 GYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR----------- 735
           G+ L  ++    +  +E   C + +      C   P       C+PG+            
Sbjct: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 200

Query: 736 -SQGGGACR----------------------DVNECAEGSPCSPGWCEN----LPGSFRC 768
            + G G C+                      D   C E    + G C++          C
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHC 260

Query: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828
           TC  G+   PD ++C D+DEC   +   + IC NT GSF+C C  GY L  +  +C+DID
Sbjct: 261 TCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDID 320

Query: 829 ECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQG 888
           EC F   C    C+NT GS++CLC +G+ L G   C D+DECS +   C     C N  G
Sbjct: 321 ECSFDRTC-DHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPG 377

Query: 889 SYVCVCDEG 897
           SY C C  G
Sbjct: 378 SYQCTCPAG 386



 Score =  146 bits (369), Expect = 1e-34
 Identities = 154/541 (28%), Positives = 220/541 (40%), Gaps = 103/541 (19%)

Query: 736  SQGGGACRDVNECAEGSP-CS-PGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECE--- 790
            +Q   A +DV+EC EG+  C     C+N P S++C C  GY    DG+ C DVDECE   
Sbjct: 21   AQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECERED 78

Query: 791  -AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYR 849
             AG V D   C N PG+++C C  G+HL+ D  +C D+DEC          C+N  GSY 
Sbjct: 79   NAGCVHD---CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYE 135

Query: 850  CLCPQGHRLVGGRKCQDIDECSQDPSL---CLP--HGA---CKNL-QGSYVCVCDEGFTP 900
            C C +G  L   +       C Q P     C+   HG    C+   +G   C C  GF  
Sbjct: 136  CHCREGFFLSDNQHT-----CIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFEL 190

Query: 901  TQDQ---------------HGCEEVEQPHHKKECYLNF---DDTVFCDSVLATNVTQQEC 942
            T++Q               H C++ EQ   +  C++ F    D   C    A N    + 
Sbjct: 191  TKNQRDCKLTCNYGNGGCQHTCDDTEQGP-RCGCHIKFVLHTDGKTCIETCAVNNGGCDS 249

Query: 943  CCSLGAGWGDHCEIYPCPV-YSSAEFHSLCPD---------GKGYTQDNNIVNYGIPAHR 992
             C   A  G HC    CPV +        C D         G  +   N + ++     +
Sbjct: 250  KCH-DAATGVHCT---CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKK 305

Query: 993  ------------DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1040
                        DIDEC       C +  CVNT   ++C C +G+   G +  C DVDEC
Sbjct: 306  GYKLLINERNCQDIDECSF--DRTC-DHICVNTPGSFQCLCHRGYLLYG-ITHCGDVDEC 361

Query: 1041 -LDESNCRNGVCENTRGGYRCACTPPAEYSPAQ---RQCLSPEEMERAP--ERRDVCWSQ 1094
             ++   CR G C NT G Y+C C  PA         + C  P + + +P   +  +  ++
Sbjct: 362  SINRGGCRFG-CINTPGSYQCTC--PAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNR 418

Query: 1095 RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSP 1154
             G+   CA      A    +       G+   C    PR A +    + + +NS      
Sbjct: 419  SGKKDTCALTCPSRARFLPE----SENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEA 474

Query: 1155 LLLGKPPRDEDSSEEDSDECRC---------VSGRCVPRPGGAVC-ECPGGF---QLDAS 1201
             +L    R   S +    +CR           +GR +  PGGA C EC   F   + D+S
Sbjct: 475  AVLSIKQR--ASFKIKDAKCRLHLRNKGKTEEAGR-ITGPGGAPCSECQVTFIHLKCDSS 531

Query: 1202 R 1202
            R
Sbjct: 532  R 532



 Score =  104 bits (260), Expect = 5e-22
 Identities = 99/391 (25%), Positives = 146/391 (37%), Gaps = 79/391 (20%)

Query: 862  RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921
            +  QD+DEC +    C     C+N   SY C+C  G+T   D   C++V+          
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVD---------- 72

Query: 922  NFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981
                               EC     AG    C   P        +   C DG     D 
Sbjct: 73   -------------------ECEREDNAGCVHDCVNIP------GNYRCTCYDGFHLAHDG 107

Query: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE-- 1039
            +          D+DEC   G+  C++  CVN    YEC+C++GF+   N   C+   E  
Sbjct: 108  HNC-------LDVDECAE-GNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEG 158

Query: 1040 --CLDESNCRNGVCENT-RGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRG 1096
              C+++++    +C  T +GG  C C P  E +  QR C           +     +++G
Sbjct: 159  MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQG 218

Query: 1097 EDGMC--AGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSP 1154
                C     L     T  + C     G  ++C        G HC            T P
Sbjct: 219  PRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDA---ATGVHC------------TCP 263

Query: 1155 LLLGKPPRDEDSSEEDSDECRCVSGRCVP----RPGGAVCECPGGFQLDASRARCVDIDE 1210
            +  G   + +  + +D DECR  +G C        G   C C  G++L  +   C DIDE
Sbjct: 264  V--GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321

Query: 1211 CRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
            C         C    CVNT GSF+C+C  G+
Sbjct: 322  C----SFDRTC-DHICVNTPGSFQCLCHRGY 347



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 36/94 (38%), Positives = 45/94 (47%), Gaps = 6/94 (6%)

Query: 1158 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            GK  +D D  E + D   CV   CV  PG   C C  GF L      C+D+DEC E N  
Sbjct: 65   GKHCKDVDECERE-DNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG 122

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
               C+ + CVN  GS+ C C+ GF  S     C+
Sbjct: 123  ---CQ-QSCVNMMGSYECHCREGFFLSDNQHTCI 152



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 23/45 (51%), Positives = 30/45 (66%), Gaps = 2/45 (4%)

Query: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPG 384
           C +GY     THC D++EC++  G CR G C+N PGSY+C CP G
Sbjct: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 2/54 (3%)

Query: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
           G     C +GYK L N  +CQDI+EC+    C H  C+N PGS++C+C  G+ L
Sbjct: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 5/86 (5%)

Query: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
           + G     C  G+   +  H C D++ECA         C+N  GSY C C  G  L  ++
Sbjct: 89  IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148

Query: 392 TQCIADKPEEKSLCFRLVSPEHQCQH 417
             CI  +PEE   C   ++  H C H
Sbjct: 149 HTCI-QRPEEGMNC---MNKNHGCAH 170



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 341 CPQGYKRLNSTHCQDINECAMP--GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
           C  GY   +  HC+D++EC       C H DC+N PG+YRC C  G  L      C+
Sbjct: 57  CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL 111



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 10/119 (8%)

Query: 698 PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPG 757
           PP    +D  +    CP G  + + G   C  C  G  ++  GA     +C     CSPG
Sbjct: 694 PPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAI-SFQDCDTKVQCSPG 752

Query: 758 WCENLP---------GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
              N           GS++    Q +     G +  D D   +   C N  C    G F
Sbjct: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 32/101 (31%), Positives = 42/101 (41%), Gaps = 19/101 (18%)

Query: 296 GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQ 354
           G T  E C  + G     SKCH       TGV             CP G+  + +   C+
Sbjct: 233 GKTCIETCAVNNGGC--DSKCHDAA----TGVH----------CTCPVGFMLQPDRKTCK 276

Query: 355 DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           DI+EC +  G C H  C N  GS+ C C  G+ L  +   C
Sbjct: 277 DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 2/39 (5%)

Query: 350 STHCQDINECAMPGVCRHGD--CLNNPGSYRCVCPPGHS 386
           S   QD++EC       H D  C N P SY+C+C  G++
Sbjct: 24  SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT 62


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  183 bits (464), Expect = 1e-45
 Identities = 113/367 (30%), Positives = 162/367 (44%), Gaps = 51/367 (13%)

Query: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG-RGI 631
           + DEC    + C     C   P  Y C C PGY+   + + C D++ECE +    G    
Sbjct: 33  DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHE 90

Query: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY 691
           C+N  G+Y C C  G+ L     G +C+D++EC + +  G    C+N  G Y+C C+ G+
Sbjct: 91  CINIPGNYRCTCFDGFML--AHDGHNCLDVDEC-QDNNGGCQQICVNAMGSYECQCHSGF 147

Query: 692 RLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR------------S 736
            L  ++       +E   C +        C   P       C+PG+             +
Sbjct: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCN 207

Query: 737 QGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFRCTC 770
            G G C+                      D   C E    + G C+    +     RC+C
Sbjct: 208 YGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSC 267

Query: 771 AQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC 830
             G+   PDG++C D++EC   +   +  C NT GSF+C C  GY L  D   C+DIDEC
Sbjct: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327

Query: 831 DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890
            F   C    CIN+ GS++CLC +G+ L G   C D+DECS     C     C N +GSY
Sbjct: 328 SFERTC-DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSY 384

Query: 891 VCVCDEG 897
            CVC  G
Sbjct: 385 ECVCPPG 391



 Score =  170 bits (431), Expect = 7e-42
 Identities = 112/349 (32%), Positives = 155/349 (44%), Gaps = 61/349 (17%)

Query: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
           Q  + DEC  +     C H EC+  P +Y C C  G+        C+DV+EC+ +  G  
Sbjct: 71  QCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGC 128

Query: 629 RGICMNTGGSYNCHCNRGYRL--------HVGAGGRSCVDLNECAKPHLCGDGGFCINFP 680
           + IC+N  GSY C C+ G+ L        H    G +C++     K H C     C   P
Sbjct: 129 QQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMN-----KDHGCAH--ICRETP 181

Query: 681 -GHYKCNCYPGYRLKASRPPV--------------CED---------------------- 703
            G   C+C PG+ L  ++                 CED                      
Sbjct: 182 KGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241

Query: 704 IDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSPGWCENL 762
           I+ C   +   D  C++     +C +C  G+  Q  G  C+D+NEC   +     +C N 
Sbjct: 242 IETCAVNNGGCDRTCKDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300

Query: 763 PGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
            GSF C C +GY    D R+C D+DEC     CD+ IC N+PGSFQC C  GY L    +
Sbjct: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILY-GTT 358

Query: 823 HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDEC 870
           HC D+DEC          C+NT GSY C+CP G RL   G+ C +  +C
Sbjct: 359 HCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407



 Score =  147 bits (371), Expect = 6e-35
 Identities = 128/471 (27%), Positives = 187/471 (39%), Gaps = 107/471 (22%)

Query: 648  RLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDE 706
            RL  G+G    VD++EC++    C     C N P  YKC C PGY+ +  +   CEDIDE
Sbjct: 21   RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ---CEDIDE 77

Query: 707  CRDP---SSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
            C +      C   +C N PG+++C        +  G  C DV+EC + +      C N  
Sbjct: 78   CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAM 136

Query: 764  GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVC---DNG---ICSNTP-GSFQCQCLSGYH 816
            GS+ C C  G+  + +  +C  +     G  C   D+G   IC  TP G   C C  G+ 
Sbjct: 137  GSYECQCHSGFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD 194

Query: 817  LSRDRSHC---------------EDIDE-----CDFPAA-------CIGGDCINTNG--- 846
            L++++  C               ED D      C    A       CI    +N  G   
Sbjct: 195  LAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDR 254

Query: 847  -------SYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
                     RC CP G  L   G+ C+DI+EC  +   C     C+N  GS+ C C +G+
Sbjct: 255  TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGY 312

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
                D+  C++++      EC  +F+ T  CD +   +    +C C              
Sbjct: 313  KLLTDERTCQDID------EC--SFERT--CDHICINSPGSFQCLCH------------- 349

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
                            +GY      + YG     D+DEC +     C +G CVNT+  YE
Sbjct: 350  ----------------RGY------ILYGTTHCGDVDECSMSNGS-CDQG-CVNTKGSYE 385

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGV---CENTRGGYRCACTPPA 1066
            C C  G     N  +CV+  +CL  +         C    G   C  + PA
Sbjct: 386  CVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPA 436



 Score =  132 bits (333), Expect = 2e-30
 Identities = 120/456 (26%), Positives = 173/456 (37%), Gaps = 108/456 (23%)

Query: 784  LDVDECEAG-DVCD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838
            +DVDEC  G D C  + IC NTP S++C C  GY    +   CEDIDEC+   +   C+ 
Sbjct: 32   VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89

Query: 839  GDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
             +CIN  G+YRC C  G  L   G  C D+DEC  +   C     C N  GSY C C  G
Sbjct: 90   -ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSYECQCHSG 146

Query: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDT------------VFCDSVLATNVTQQECCCS 945
            F  + +QH C  + + +    C +N D              V CD     ++ Q +  C+
Sbjct: 147  FFLSDNQHTC--IHRSNEGMNC-MNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT 203

Query: 946  LGAGWGDHCEIYPC------PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999
            L   +G+    + C      P     + ++L  DG+   +   + N G            
Sbjct: 204  LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC----------- 252

Query: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR 1059
                   +  C +T  G  C C  GF    +   C D++ECL  +   +  C NT G + 
Sbjct: 253  -------DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFE 305

Query: 1060 CACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
            C C    +    +R C   +E          C  +R  D +C   +  P  +F   C R 
Sbjct: 306  CGCRKGYKLLTDERTCQDIDE----------CSFERTCDHIC---INSPG-SFQCLCHRG 351

Query: 1120 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1179
               +G            +HC                              D DEC   +G
Sbjct: 352  YILYGT-----------THC-----------------------------GDVDECSMSNG 371

Query: 1180 R----CVPRPGGAVCECPGGFQLDASRARCVDIDEC 1211
                 CV   G   C CP G +L  +   CV+  +C
Sbjct: 372  SCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407



 Score =  104 bits (260), Expect = 5e-22
 Identities = 60/182 (32%), Positives = 84/182 (46%), Gaps = 10/182 (5%)

Query: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
           + C +N   C    C        C C  G+   P  + C D+NEC     G     C NT
Sbjct: 243 ETCAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNT 300

Query: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKA 695
            GS+ C C +GY+L      R+C D++EC+    C     CIN PG ++C C+ GY L  
Sbjct: 301 VGSFECGCRKGYKLLTDE--RTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYG 356

Query: 696 SRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPC 754
           +    C D+DEC   +   D  C N  GS++C+ C PG R    G  C +  +C   +  
Sbjct: 357 TTH--CGDVDECSMSNGSCDQGCVNTKGSYECV-CPPGRRLHWNGKDCVETGKCLSRAKT 413

Query: 755 SP 756
           SP
Sbjct: 414 SP 415



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 116/513 (22%), Positives = 180/513 (35%), Gaps = 95/513 (18%)

Query: 290 GSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN 349
           G + LPG    ++C          + C   P+  Y  + KPG  +GE             
Sbjct: 24  GGSGLPGSVDVDECSEGTDDCHIDAICQNTPK-SYKCLCKPG-YKGE------------- 68

Query: 350 STHCQDINECAMP---GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKPEE---- 401
              C+DI+EC      G C H +C+N PG+YRC C  G  L      C+  D+ ++    
Sbjct: 69  GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127

Query: 402 -KSLCFRLV-SPEHQC---------QHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450
            + +C   + S E QC         QH    R    + C +        C+  P  G A 
Sbjct: 128 CQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA- 186

Query: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEER 510
               C    G+ +  + +  T+          H              +   P     ++ 
Sbjct: 187 ----CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC----------EDTDTGPTCGCHQKY 232

Query: 511 GVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
            + +D     E     +     T          S P   T++      P  ++  +I   
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ------PDGKTCKDINEC 286

Query: 571 QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGR 629
            V         +N  G  EC          C  GY+     R C D++EC  E  C    
Sbjct: 287 LVNNGGCDHFCRNTVGSFEC---------GCRKGYKLLTDERTCQDIDECSFERTCD--- 334

Query: 630 GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
            IC+N+ GS+ C C+RGY L+   G   C D++EC+  +   D G C+N  G Y+C C P
Sbjct: 335 HICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPP 390

Query: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
           G RL  +         +C +   C      +      C        S+ GG    V  C 
Sbjct: 391 GRRLHWNG-------KDCVETGKCLSRAKTSPRAQLSC--------SKAGG----VESCF 431

Query: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
              P    +  +   S+  +C     P P G++
Sbjct: 432 LSCPAHTLFVPDSENSYVLSCG---VPGPQGKA 461



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 97/422 (22%), Positives = 144/422 (34%), Gaps = 89/422 (21%)

Query: 857  RLVGGRKCQ---DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQP 913
            RL GG       D+DECS+    C     C+N   SY C+C  G+     Q  CE++++ 
Sbjct: 21   RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDE- 77

Query: 914  HHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD 973
                           C++         EC                  +     +   C D
Sbjct: 78   ---------------CENDYYNGGCVHEC------------------INIPGNYRCTCFD 104

Query: 974  GKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLE 1033
            G     D +          D+DEC    +  C++  CVN    YEC C  GF+   N   
Sbjct: 105  GFMLAHDGHNC-------LDVDECQ-DNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHT 155

Query: 1034 CVDVDE----CLDESNCRNGVCENT-RGGYRCACTPPAEYSPAQRQCLSPEEMERAPERR 1088
            C+        C+++ +    +C  T +GG  C C P  + +  Q+ C           + 
Sbjct: 156  CIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQH 215

Query: 1089 DVCWSQRGEDGMCAGPLA--GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP---TSQ 1143
                +  G    C    A      T  + C     G    C+     G    CP   T Q
Sbjct: 216  SCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTAT-GVRCSCPVGFTLQ 274

Query: 1144 SESNSFWDTSPLLLGKPPRD----------------------EDSSEEDSDEC---RCVS 1178
             +  +  D +  L+     D                      ++ + +D DEC   R   
Sbjct: 275  PDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCD 334

Query: 1179 GRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCK 1238
              C+  PG   C C  G+ L  +   C D+DEC   N     C  + CVNT GS+ CVC 
Sbjct: 335  HICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGS---C-DQGCVNTKGSYECVCP 389

Query: 1239 AG 1240
             G
Sbjct: 390  PG 391



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 38/117 (32%), Positives = 52/117 (44%), Gaps = 14/117 (11%)

Query: 281 QDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGA 339
           ++T+    CG      L   E  C  I     +  C H C       +  PG  +     
Sbjct: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHIC-------INSPGSFQ----C 346

Query: 340 DCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
            C +GY    +THC D++EC+M  G C  G C+N  GSY CVCPPG  L  +   C+
Sbjct: 347 LCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 5/94 (5%)

Query: 1158 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
            GK   D D  E D     CV   C+  PG   C C  GF L      C+D+DEC++ N  
Sbjct: 69   GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127

Query: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
               C+ + CVN  GS+ C C +GF  S     C+
Sbjct: 128  ---CQ-QICVNAMGSYECQCHSGFFLSDNQHTCI 157



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 40/150 (26%), Positives = 56/150 (37%), Gaps = 36/150 (24%)

Query: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG---RS 782
           KC+AC PG    G     ++ +C     C PG  +++ G   CT      P+ DG     
Sbjct: 629 KCVACGPGTHFGG-----ELGQCVS---CMPGTYQDMEGQLSCT----PCPSSDGLGLPG 676

Query: 783 CLDVDECEAGDVCDNGICSNTPGSFQCQC--LSGYHLSRDRSHC--------------ED 826
             +V EC  G  C  G  S   G   CQ   +  Y     R+ C                
Sbjct: 677 ARNVSEC--GGQCSPGFFS-ADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTS 733

Query: 827 IDECDFPAACIGGDCINTNGSYRCL-CPQG 855
             +C+    C  G   NT  ++RC+ CP G
Sbjct: 734 FQDCEAKVHCSPGHHYNTT-THRCIRCPVG 762



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 38/169 (22%), Positives = 56/169 (33%), Gaps = 30/169 (17%)

Query: 668 HLCGDGGFCIN-FPGHYK-----CNCYPGYRLKASRPPVCEDIDECRDPSS--------- 712
           H  G+ G C++  PG Y+      +C P         P   ++ EC    S         
Sbjct: 638 HFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697

Query: 713 -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGW--------C 759
                CP G  + +PG   C  C  G  ++  G      +C     CSPG         C
Sbjct: 698 KPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT-TSFQDCEAKVHCSPGHHYNTTTHRC 756

Query: 760 ENLP-GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
              P G+++    Q +     G +  D D       C N  C    G +
Sbjct: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY 805


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  181 bits (458), Expect = 5e-45
 Identities = 114/327 (34%), Positives = 153/327 (46%), Gaps = 43/327 (13%)

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            C  G+    Q  +CVD +EC   P  P    C+N  G ++C C  G+ L      R+C D
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGP-SPCSHACLNAPGRFSCTCPTGFAL--AWDDRNCRD 3484

Query: 661  LNECA-KPHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDECRDP-SSCPDG 716
            ++ECA   HLC +G  C+N  G Y+C  +C PG+R+       CED+DEC +    C   
Sbjct: 3485 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG--CEDVDECLEGLDDCHYN 3542

Query: 717  K-CENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGY 774
            + CEN PG  +C +C  GYR QG    C DVNEC +        C NL GS+RC C  G 
Sbjct: 3543 QLCENTPGGHRC-SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQ 3601

Query: 775  APAPDGRSCLDVDE---------------------CEAGDVCDNGICSNTPGSF------ 807
                DG++C  ++                              +   S  PG        
Sbjct: 3602 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 3661

Query: 808  QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQD 866
            +  C  G+   R    C D+DEC     C    C NT GSY+CLCP G+RL+  G+ CQD
Sbjct: 3662 RAWCPPGF--IRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYRLLPSGKNCQD 3718

Query: 867  IDECSQDPSLCLPHGACKNLQGSYVCV 893
            I+EC ++   C P   C N +GSY CV
Sbjct: 3719 INECEEESIECGPGQMCFNTRGSYQCV 3745



 Score =  170 bits (431), Expect = 7e-42
 Identities = 121/353 (34%), Positives = 168/353 (47%), Gaps = 37/353 (10%)

Query: 728  IACQPGYRSQGGGA-CRDVNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
            + C  G+     GA C D +EC+ G SPCS   C N PG F CTC  G+A A D R+C D
Sbjct: 3426 VGCPEGFELDSQGAFCVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGFALAWDDRNCRD 3484

Query: 786  VDECE-AGDVCDNG-ICSNTPGSFQC--QCLSGYHLSRDRSHCEDIDEC--DFPAACIGG 839
            VDEC     +C  G  C N  GS++C   C  G+ ++ D + CED+DEC           
Sbjct: 3485 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQ 3543

Query: 840  DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
             C NT G +RC CP+G+R+ G    C D++EC Q P  C     C NLQGSY C+C  G 
Sbjct: 3544 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCPPGQ 3601

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
            T  +D   C  +E+         N  +              +      G  +     + P
Sbjct: 3602 TLLRDGKACTSLER---------NGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRP 3652

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
             P+  S+   + CP   G+ + N +         D+DEC +    +C+   C NT+  Y+
Sbjct: 3653 GPMALSSVGRAWCP--PGFIRQNGVCT-------DLDECRV--RNLCQHA-CRNTEGSYQ 3700

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDES-NCRNG-VCENTRGGYRCACTP-PAEY 1068
            C C  G+    +   C D++EC +ES  C  G +C NTRG Y+C  TP PA Y
Sbjct: 3701 CLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATY 3753



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 94/333 (28%), Positives = 127/333 (38%), Gaps = 49/333 (14%)

Query: 952  DHCEIYPCP-----VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK 1006
            D C   P P     + +   F   CP G     D+          RD+DEC  + + +C+
Sbjct: 3445 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-------RDVDECA-WDAHLCR 3496

Query: 1007 EG-KCVNTQPGYECY--CKQGFYY-DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
            EG +CVN    Y C   C  GF   DG    C DVDECL+   +C  N +CENT GG+RC
Sbjct: 3497 EGQRCVNLLGSYRCLPDCGPGFRVADG--AGCEDVDECLEGLDDCHYNQLCENTPGGHRC 3554

Query: 1061 ACTPPAEYSPAQRQCLSPEEMERAPERRDV-CWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
            +C            CL   E  + P+     C + +G       P  G  L  D   C  
Sbjct: 3555 SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPP--GQTLLRDGKACTS 3612

Query: 1120 GRGWGAQCRPCPPRGA-------GSHCPTSQSESNSFWDTSPLLLGKPPRD--------E 1164
                G        RG         +  P +   +       P+ L    R         +
Sbjct: 3613 LERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQ 3672

Query: 1165 DSSEEDSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLC 1221
            +    D DECR        C    G   C CP G++L  S   C DI+EC E     + C
Sbjct: 3673 NGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEE---ESIEC 3729

Query: 1222 -KSERCVNTSGSFRCV---CKAGFARSRPHGAC 1250
               + C NT GS++CV   C A + +    G C
Sbjct: 3730 GPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3762



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 99/370 (26%), Positives = 137/370 (37%), Gaps = 88/370 (23%)

Query: 335  GEVGADCPQGYKRL-NSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV--CPPGHSLGP 389
            G     CP G+    +  +C+D++ECA    +CR G  C+N  GSYRC+  C PG  +  
Sbjct: 3463 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 3522

Query: 390  SR-----TQCI--ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC-------CCSVGKA 435
                    +C+   D      LC       H+C  P   R+            C  + KA
Sbjct: 3523 GAGCEDVDECLEGLDDCHYNQLC-ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKA 3581

Query: 436  WGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE 495
               +C         +++ +CP G         QTL   G++  SL               
Sbjct: 3582 CAYQCHNL----QGSYRCLCPPG---------QTLLRDGKACTSL--------------- 3613

Query: 496  SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELIS-RPSPPTM--- 551
                         ER     + VS    +        + P   Y   +S RP P  +   
Sbjct: 3614 -------------ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSV 3660

Query: 552  --RWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHP 609
               W  P                T+ DECR+ +N+C H  C      Y C C  GYR  P
Sbjct: 3661 GRAWCPPGFIRQNGV-------CTDLDECRV-RNLCQHA-CRNTEGSYQCLCPAGYRLLP 3711

Query: 610  QHRYCVDVNECEAE--PCGPGRGICMNTGGSYNC---HCNRGYRLHVGAGGRSCVDLNEC 664
              + C D+NECE E   CGPG+ +C NT GSY C    C   YR   G    +C     C
Sbjct: 3712 SGKNCQDINECEEESIECGPGQ-MCFNTRGSYQCVDTPCPATYR--QGPSPGTC--FRRC 3766

Query: 665  AKPHLCGDGG 674
            ++   CG GG
Sbjct: 3767 SQD--CGTGG 3774



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 62/242 (25%), Positives = 83/242 (34%), Gaps = 55/242 (22%)

Query: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
            E  C +GF  D     CVD DEC    +  +  C N  G + C C      +   R C  
Sbjct: 3425 EVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-- 3482

Query: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ-CRPCPPRGAG 1136
                      RDV                      D+C       W A  CR       G
Sbjct: 3483 ----------RDV----------------------DECA------WDAHLCRE------G 3498

Query: 1137 SHCPTSQSESNSFWDTSP---LLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECP 1193
              C           D  P   +  G    D D   E  D+C   +  C   PGG  C CP
Sbjct: 3499 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCH-YNQLCENTPGGHRCSCP 3557

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1253
             G+++      C+D++EC +L +      + +C N  GS+RC+C  G    R   AC   
Sbjct: 3558 RGYRMQGPSLPCLDVNECLQLPK----ACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSL 3613

Query: 1254 RR 1255
             R
Sbjct: 3614 ER 3615



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 6/81 (7%)

Query: 329  KPGPVR-GEVG-ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
            +PGP+    VG A CP G+ R N   C D++EC +  +C+H  C N  GSY+C+CP G+ 
Sbjct: 3651 RPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYR 3708

Query: 387  LGPSRTQC--IADKPEEKSLC 405
            L PS   C  I +  EE   C
Sbjct: 3709 LLPSGKNCQDINECEEESIEC 3729



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 36/107 (33%), Positives = 46/107 (42%), Gaps = 18/107 (16%)

Query: 295  PGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-TH 352
            PG  +Q   C  +     ++ C H C   +           G     CP GY+ L S  +
Sbjct: 3667 PGFIRQNGVCTDLDECRVRNLCQHACRNTE-----------GSYQCLCPAGYRLLPSGKN 3715

Query: 353  CQDINECAMPGV-CRHGD-CLNNPGSYRCV---CPPGHSLGPSRTQC 394
            CQDINEC    + C  G  C N  GSY+CV   CP  +  GPS   C
Sbjct: 3716 CQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3762


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  181 bits (458), Expect = 5e-45
 Identities = 114/327 (34%), Positives = 153/327 (46%), Gaps = 43/327 (13%)

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            C  G+    Q  +CVD +EC   P  P    C+N  G ++C C  G+ L      R+C D
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGP-SPCSHACLNAPGRFSCTCPTGFAL--AWDDRNCRD 4675

Query: 661  LNECA-KPHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDECRDP-SSCPDG 716
            ++ECA   HLC +G  C+N  G Y+C  +C PG+R+       CED+DEC +    C   
Sbjct: 4676 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG--CEDVDECLEGLDDCHYN 4733

Query: 717  K-CENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGY 774
            + CEN PG  +C +C  GYR QG    C DVNEC +        C NL GS+RC C  G 
Sbjct: 4734 QLCENTPGGHRC-SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQ 4792

Query: 775  APAPDGRSCLDVDE---------------------CEAGDVCDNGICSNTPGSF------ 807
                DG++C  ++                              +   S  PG        
Sbjct: 4793 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 4852

Query: 808  QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQD 866
            +  C  G+   R    C D+DEC     C    C NT GSY+CLCP G+RL+  G+ CQD
Sbjct: 4853 RAWCPPGF--IRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYRLLPSGKNCQD 4909

Query: 867  IDECSQDPSLCLPHGACKNLQGSYVCV 893
            I+EC ++   C P   C N +GSY CV
Sbjct: 4910 INECEEESIECGPGQMCFNTRGSYQCV 4936



 Score =  170 bits (431), Expect = 7e-42
 Identities = 121/353 (34%), Positives = 168/353 (47%), Gaps = 37/353 (10%)

Query: 728  IACQPGYRSQGGGA-CRDVNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
            + C  G+     GA C D +EC+ G SPCS   C N PG F CTC  G+A A D R+C D
Sbjct: 4617 VGCPEGFELDSQGAFCVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGFALAWDDRNCRD 4675

Query: 786  VDECE-AGDVCDNG-ICSNTPGSFQC--QCLSGYHLSRDRSHCEDIDEC--DFPAACIGG 839
            VDEC     +C  G  C N  GS++C   C  G+ ++ D + CED+DEC           
Sbjct: 4676 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQ 4734

Query: 840  DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
             C NT G +RC CP+G+R+ G    C D++EC Q P  C     C NLQGSY C+C  G 
Sbjct: 4735 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCPPGQ 4792

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
            T  +D   C  +E+         N  +              +      G  +     + P
Sbjct: 4793 TLLRDGKACTSLER---------NGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRP 4843

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
             P+  S+   + CP   G+ + N +         D+DEC +    +C+   C NT+  Y+
Sbjct: 4844 GPMALSSVGRAWCP--PGFIRQNGVCT-------DLDECRV--RNLCQHA-CRNTEGSYQ 4891

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDES-NCRNG-VCENTRGGYRCACTP-PAEY 1068
            C C  G+    +   C D++EC +ES  C  G +C NTRG Y+C  TP PA Y
Sbjct: 4892 CLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATY 4944



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 94/333 (28%), Positives = 127/333 (38%), Gaps = 49/333 (14%)

Query: 952  DHCEIYPCP-----VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK 1006
            D C   P P     + +   F   CP G     D+          RD+DEC  + + +C+
Sbjct: 4636 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-------RDVDECA-WDAHLCR 4687

Query: 1007 EG-KCVNTQPGYECY--CKQGFYY-DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
            EG +CVN    Y C   C  GF   DG    C DVDECL+   +C  N +CENT GG+RC
Sbjct: 4688 EGQRCVNLLGSYRCLPDCGPGFRVADG--AGCEDVDECLEGLDDCHYNQLCENTPGGHRC 4745

Query: 1061 ACTPPAEYSPAQRQCLSPEEMERAPERRDV-CWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
            +C            CL   E  + P+     C + +G       P  G  L  D   C  
Sbjct: 4746 SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPP--GQTLLRDGKACTS 4803

Query: 1120 GRGWGAQCRPCPPRGA-------GSHCPTSQSESNSFWDTSPLLLGKPPRD--------E 1164
                G        RG         +  P +   +       P+ L    R         +
Sbjct: 4804 LERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQ 4863

Query: 1165 DSSEEDSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLC 1221
            +    D DECR        C    G   C CP G++L  S   C DI+EC E     + C
Sbjct: 4864 NGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEE---ESIEC 4920

Query: 1222 -KSERCVNTSGSFRCV---CKAGFARSRPHGAC 1250
               + C NT GS++CV   C A + +    G C
Sbjct: 4921 GPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 4953



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 99/370 (26%), Positives = 137/370 (37%), Gaps = 88/370 (23%)

Query: 335  GEVGADCPQGYKRL-NSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV--CPPGHSLGP 389
            G     CP G+    +  +C+D++ECA    +CR G  C+N  GSYRC+  C PG  +  
Sbjct: 4654 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 4713

Query: 390  SR-----TQCI--ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC-------CCSVGKA 435
                    +C+   D      LC       H+C  P   R+            C  + KA
Sbjct: 4714 GAGCEDVDECLEGLDDCHYNQLC-ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKA 4772

Query: 436  WGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE 495
               +C         +++ +CP G         QTL   G++  SL               
Sbjct: 4773 CAYQCHNL----QGSYRCLCPPG---------QTLLRDGKACTSL--------------- 4804

Query: 496  SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELIS-RPSPPTM--- 551
                         ER     + VS    +        + P   Y   +S RP P  +   
Sbjct: 4805 -------------ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSV 4851

Query: 552  --RWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHP 609
               W  P                T+ DECR+ +N+C H  C      Y C C  GYR  P
Sbjct: 4852 GRAWCPPGFIRQNGV-------CTDLDECRV-RNLCQHA-CRNTEGSYQCLCPAGYRLLP 4902

Query: 610  QHRYCVDVNECEAE--PCGPGRGICMNTGGSYNC---HCNRGYRLHVGAGGRSCVDLNEC 664
              + C D+NECE E   CGPG+ +C NT GSY C    C   YR   G    +C     C
Sbjct: 4903 SGKNCQDINECEEESIECGPGQ-MCFNTRGSYQCVDTPCPATYR--QGPSPGTC--FRRC 4957

Query: 665  AKPHLCGDGG 674
            ++   CG GG
Sbjct: 4958 SQD--CGTGG 4965



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 62/242 (25%), Positives = 83/242 (34%), Gaps = 55/242 (22%)

Query: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
            E  C +GF  D     CVD DEC    +  +  C N  G + C C      +   R C  
Sbjct: 4616 EVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-- 4673

Query: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ-CRPCPPRGAG 1136
                      RDV                      D+C       W A  CR       G
Sbjct: 4674 ----------RDV----------------------DECA------WDAHLCRE------G 4689

Query: 1137 SHCPTSQSESNSFWDTSP---LLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECP 1193
              C           D  P   +  G    D D   E  D+C   +  C   PGG  C CP
Sbjct: 4690 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCH-YNQLCENTPGGHRCSCP 4748

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1253
             G+++      C+D++EC +L +      + +C N  GS+RC+C  G    R   AC   
Sbjct: 4749 RGYRMQGPSLPCLDVNECLQLPK----ACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSL 4804

Query: 1254 RR 1255
             R
Sbjct: 4805 ER 4806



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 6/81 (7%)

Query: 329  KPGPVR-GEVG-ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
            +PGP+    VG A CP G+ R N   C D++EC +  +C+H  C N  GSY+C+CP G+ 
Sbjct: 4842 RPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYR 4899

Query: 387  LGPSRTQC--IADKPEEKSLC 405
            L PS   C  I +  EE   C
Sbjct: 4900 LLPSGKNCQDINECEEESIEC 4920



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 36/107 (33%), Positives = 46/107 (42%), Gaps = 18/107 (16%)

Query: 295  PGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-TH 352
            PG  +Q   C  +     ++ C H C   +           G     CP GY+ L S  +
Sbjct: 4858 PGFIRQNGVCTDLDECRVRNLCQHACRNTE-----------GSYQCLCPAGYRLLPSGKN 4906

Query: 353  CQDINECAMPGV-CRHGD-CLNNPGSYRCV---CPPGHSLGPSRTQC 394
            CQDINEC    + C  G  C N  GSY+CV   CP  +  GPS   C
Sbjct: 4907 CQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 4953


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  181 bits (458), Expect = 5e-45
 Identities = 114/327 (34%), Positives = 153/327 (46%), Gaps = 43/327 (13%)

Query: 601  CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
            C  G+    Q  +CVD +EC   P  P    C+N  G ++C C  G+ L      R+C D
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGP-SPCSHACLNAPGRFSCTCPTGFAL--AWDDRNCRD 3393

Query: 661  LNECA-KPHLCGDGGFCINFPGHYKC--NCYPGYRLKASRPPVCEDIDECRDP-SSCPDG 716
            ++ECA   HLC +G  C+N  G Y+C  +C PG+R+       CED+DEC +    C   
Sbjct: 3394 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG--CEDVDECLEGLDDCHYN 3451

Query: 717  K-CENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGY 774
            + CEN PG  +C +C  GYR QG    C DVNEC +        C NL GS+RC C  G 
Sbjct: 3452 QLCENTPGGHRC-SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQ 3510

Query: 775  APAPDGRSCLDVDE---------------------CEAGDVCDNGICSNTPGSF------ 807
                DG++C  ++                              +   S  PG        
Sbjct: 3511 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 3570

Query: 808  QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQD 866
            +  C  G+   R    C D+DEC     C    C NT GSY+CLCP G+RL+  G+ CQD
Sbjct: 3571 RAWCPPGF--IRQNGVCTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYRLLPSGKNCQD 3627

Query: 867  IDECSQDPSLCLPHGACKNLQGSYVCV 893
            I+EC ++   C P   C N +GSY CV
Sbjct: 3628 INECEEESIECGPGQMCFNTRGSYQCV 3654



 Score =  170 bits (431), Expect = 7e-42
 Identities = 121/353 (34%), Positives = 168/353 (47%), Gaps = 37/353 (10%)

Query: 728  IACQPGYRSQGGGA-CRDVNECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
            + C  G+     GA C D +EC+ G SPCS   C N PG F CTC  G+A A D R+C D
Sbjct: 3335 VGCPEGFELDSQGAFCVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGFALAWDDRNCRD 3393

Query: 786  VDECE-AGDVCDNG-ICSNTPGSFQC--QCLSGYHLSRDRSHCEDIDEC--DFPAACIGG 839
            VDEC     +C  G  C N  GS++C   C  G+ ++ D + CED+DEC           
Sbjct: 3394 VDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQ 3452

Query: 840  DCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
             C NT G +RC CP+G+R+ G    C D++EC Q P  C     C NLQGSY C+C  G 
Sbjct: 3453 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCPPGQ 3510

Query: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
            T  +D   C  +E+         N  +              +      G  +     + P
Sbjct: 3511 TLLRDGKACTSLER---------NGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRP 3561

Query: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
             P+  S+   + CP   G+ + N +         D+DEC +    +C+   C NT+  Y+
Sbjct: 3562 GPMALSSVGRAWCP--PGFIRQNGVCT-------DLDECRV--RNLCQHA-CRNTEGSYQ 3609

Query: 1019 CYCKQGFYYDGNLLECVDVDECLDES-NCRNG-VCENTRGGYRCACTP-PAEY 1068
            C C  G+    +   C D++EC +ES  C  G +C NTRG Y+C  TP PA Y
Sbjct: 3610 CLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATY 3662



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 94/333 (28%), Positives = 127/333 (38%), Gaps = 49/333 (14%)

Query: 952  DHCEIYPCP-----VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK 1006
            D C   P P     + +   F   CP G     D+          RD+DEC  + + +C+
Sbjct: 3354 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-------RDVDECA-WDAHLCR 3405

Query: 1007 EG-KCVNTQPGYECY--CKQGFYY-DGNLLECVDVDECLDE-SNCR-NGVCENTRGGYRC 1060
            EG +CVN    Y C   C  GF   DG    C DVDECL+   +C  N +CENT GG+RC
Sbjct: 3406 EGQRCVNLLGSYRCLPDCGPGFRVADG--AGCEDVDECLEGLDDCHYNQLCENTPGGHRC 3463

Query: 1061 ACTPPAEYSPAQRQCLSPEEMERAPERRDV-CWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
            +C            CL   E  + P+     C + +G       P  G  L  D   C  
Sbjct: 3464 SCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPP--GQTLLRDGKACTS 3521

Query: 1120 GRGWGAQCRPCPPRGA-------GSHCPTSQSESNSFWDTSPLLLGKPPRD--------E 1164
                G        RG         +  P +   +       P+ L    R         +
Sbjct: 3522 LERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQ 3581

Query: 1165 DSSEEDSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLC 1221
            +    D DECR        C    G   C CP G++L  S   C DI+EC E     + C
Sbjct: 3582 NGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEE---ESIEC 3638

Query: 1222 -KSERCVNTSGSFRCV---CKAGFARSRPHGAC 1250
               + C NT GS++CV   C A + +    G C
Sbjct: 3639 GPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3671



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 99/370 (26%), Positives = 137/370 (37%), Gaps = 88/370 (23%)

Query: 335  GEVGADCPQGYKRL-NSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV--CPPGHSLGP 389
            G     CP G+    +  +C+D++ECA    +CR G  C+N  GSYRC+  C PG  +  
Sbjct: 3372 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 3431

Query: 390  SR-----TQCI--ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC-------CCSVGKA 435
                    +C+   D      LC       H+C  P   R+            C  + KA
Sbjct: 3432 GAGCEDVDECLEGLDDCHYNQLC-ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKA 3490

Query: 436  WGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE 495
               +C         +++ +CP G         QTL   G++  SL               
Sbjct: 3491 CAYQCHNL----QGSYRCLCPPG---------QTLLRDGKACTSL--------------- 3522

Query: 496  SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELIS-RPSPPTM--- 551
                         ER     + VS    +        + P   Y   +S RP P  +   
Sbjct: 3523 -------------ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSV 3569

Query: 552  --RWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHP 609
               W  P                T+ DECR+ +N+C H  C      Y C C  GYR  P
Sbjct: 3570 GRAWCPPGFIRQNGV-------CTDLDECRV-RNLCQHA-CRNTEGSYQCLCPAGYRLLP 3620

Query: 610  QHRYCVDVNECEAE--PCGPGRGICMNTGGSYNC---HCNRGYRLHVGAGGRSCVDLNEC 664
              + C D+NECE E   CGPG+ +C NT GSY C    C   YR   G    +C     C
Sbjct: 3621 SGKNCQDINECEEESIECGPGQ-MCFNTRGSYQCVDTPCPATYR--QGPSPGTC--FRRC 3675

Query: 665  AKPHLCGDGG 674
            ++   CG GG
Sbjct: 3676 SQD--CGTGG 3683



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 62/242 (25%), Positives = 83/242 (34%), Gaps = 55/242 (22%)

Query: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
            E  C +GF  D     CVD DEC    +  +  C N  G + C C      +   R C  
Sbjct: 3334 EVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC-- 3391

Query: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ-CRPCPPRGAG 1136
                      RDV                      D+C       W A  CR       G
Sbjct: 3392 ----------RDV----------------------DECA------WDAHLCRE------G 3407

Query: 1137 SHCPTSQSESNSFWDTSP---LLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECP 1193
              C           D  P   +  G    D D   E  D+C   +  C   PGG  C CP
Sbjct: 3408 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCH-YNQLCENTPGGHRCSCP 3466

Query: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1253
             G+++      C+D++EC +L +      + +C N  GS+RC+C  G    R   AC   
Sbjct: 3467 RGYRMQGPSLPCLDVNECLQLPK----ACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSL 3522

Query: 1254 RR 1255
             R
Sbjct: 3523 ER 3524



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 6/81 (7%)

Query: 329  KPGPVR-GEVG-ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHS 386
            +PGP+    VG A CP G+ R N   C D++EC +  +C+H  C N  GSY+C+CP G+ 
Sbjct: 3560 RPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRVRNLCQHA-CRNTEGSYQCLCPAGYR 3617

Query: 387  LGPSRTQC--IADKPEEKSLC 405
            L PS   C  I +  EE   C
Sbjct: 3618 LLPSGKNCQDINECEEESIEC 3638



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 36/107 (33%), Positives = 46/107 (42%), Gaps = 18/107 (16%)

Query: 295  PGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-TH 352
            PG  +Q   C  +     ++ C H C   +           G     CP GY+ L S  +
Sbjct: 3576 PGFIRQNGVCTDLDECRVRNLCQHACRNTE-----------GSYQCLCPAGYRLLPSGKN 3624

Query: 353  CQDINECAMPGV-CRHGD-CLNNPGSYRCV---CPPGHSLGPSRTQC 394
            CQDINEC    + C  G  C N  GSY+CV   CP  +  GPS   C
Sbjct: 3625 CQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3671


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  176 bits (447), Expect = 1e-43
 Identities = 117/335 (34%), Positives = 151/335 (45%), Gaps = 22/335 (6%)

Query: 590 CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNC--HCNRG 646
           C+P P +    C  G+    Q   C+D++EC   P    G  +C+N  G Y C    N  
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 647 YR-LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
           YR  +              A P L       I+ P      C  GY++  S    C D+D
Sbjct: 76  YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRP----LICRFGYQMDESNQ--CVDVD 129

Query: 706 ECR-DPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
           EC  D   C P   C N  G + C +C  GY    G  C D++EC  G  C    C N+P
Sbjct: 130 ECATDSHQCNPTQICINTEGGYTC-SCTDGYWLLEG-QCLDIDECRYGY-CQQ-LCANVP 185

Query: 764 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSH 823
           GS+ CTC  G+    DGRSC DV+EC   + C    C NT GSF C+C  GY L  D  H
Sbjct: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244

Query: 824 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA 882
           C D+DEC F       +C+N  G+Y C CP G+ L+   R CQDI+EC      C     
Sbjct: 245 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 304

Query: 883 CKNLQGSYVCV----CDEGFTPTQDQHGCEEVEQP 913
           C NLQG + C+    C+E +    D       E P
Sbjct: 305 CYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339



 Score =  106 bits (265), Expect = 1e-22
 Identities = 88/344 (25%), Positives = 132/344 (38%), Gaps = 83/344 (24%)

Query: 799  ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGD-CINTNGSYRCL----- 851
            +C  +PG+ Q QC +G+ L R    C DIDEC   P AC G   C+N NG Y C+     
Sbjct: 15   LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74

Query: 852  --------------------------------------CPQGHRLVGGRKCQDIDECSQD 873
                                                  C  G+++    +C D+DEC+ D
Sbjct: 75   VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134

Query: 874  PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVL 933
               C P   C N +G Y C C +G+   + Q  C +++      EC        +C  + 
Sbjct: 135  SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDID------ECRYG-----YCQQLC 181

Query: 934  ATNVTQQECCCSLGAGW---GDHCEIY-------PCPVYSSAEFHS-LCPDGKGYTQDNN 982
            A       C C+ G      G  C+         PC       + S +C    GY  + +
Sbjct: 182  ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEED 241

Query: 983  IVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
             V+       D+DEC    SE   + +CVN    Y C C  G+    +   C D++EC  
Sbjct: 242  GVHCS-----DMDECSF--SEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEH 294

Query: 1043 ESNCRN--GVCENTRGGYRC----ACTPPAEYSPAQRQCLSPEE 1080
             ++  N    C N +GG++C     C  P     +  +C+ P E
Sbjct: 295  RNHTCNLQQTCYNLQGGFKCIDPIRCEEP-YLRISDNRCMCPAE 337



 Score =  101 bits (252), Expect = 4e-21
 Identities = 72/192 (37%), Positives = 89/192 (46%), Gaps = 37/192 (19%)

Query: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
           Q  + DECR    Q +C +   VPG   YSC CNPG+  +   R C DVNEC  E   P 
Sbjct: 165 QCLDIDECRYGYCQQLCAN---VPG--SYSCTCNPGFTLNEDGRSCQDVNECATE--NPC 217

Query: 629 RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNC 687
              C+NT GS+ C C+ GY L     G  C D++EC+    LC     C+N PG Y C+C
Sbjct: 218 VQTCVNTYGSFICRCDPGYELE--EDGVHCSDMDECSFSEFLCQHE--CVNQPGTYFCSC 273

Query: 688 YPGYRLKASRPPVCEDIDEC--RDPSSCPDGKCENKPGSFKCI----------------- 728
            PGY L       C+DI+EC  R+ +      C N  G FKCI                 
Sbjct: 274 PPGYILLDDNRS-CQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC 332

Query: 729 ---ACQPGYRSQ 737
              A  PG R Q
Sbjct: 333 MCPAENPGCRDQ 344



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 94/405 (23%), Positives = 126/405 (31%), Gaps = 114/405 (28%)

Query: 841  CINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT 899
            C+ + G+ +  C  G  L     +C DIDEC   P  C     C N  G Y+        
Sbjct: 16   CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYL-------- 67

Query: 900  PTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPC 959
                   C     P ++   Y N   T +     A                         
Sbjct: 68   -------CIPRTNPVYRGP-YSNPYSTPYSGPYPAA------------------APPLSA 101

Query: 960  PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
            P Y +     +C  G    + N  V        D+DEC     +      C+NT+ GY C
Sbjct: 102  PNYPTISRPLICRFGYQMDESNQCV--------DVDECATDSHQCNPTQICINTEGGYTC 153

Query: 1020 YCKQGFYYDGNLLECVDVDECLDESNCRNGVCE----NTRGGYRCACTPPAEYSPAQRQC 1075
             C  G++    LLE     +CLD   CR G C+    N  G Y C C P    +   R C
Sbjct: 154  SCTDGYW----LLE----GQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSC 205

Query: 1076 LSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA 1135
                E          C ++      C         T+    CR   G+  +         
Sbjct: 206  QDVNE----------CATENPCVQTCVN-------TYGSFICRCDPGYELE-------ED 241

Query: 1136 GSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCE 1191
            G HC                              D DEC          CV +PG   C 
Sbjct: 242  GVHC-----------------------------SDMDECSFSEFLCQHECVNQPGTYFCS 272

Query: 1192 CPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
            CP G+ L      C DI+EC   N    L   + C N  G F+C+
Sbjct: 273  CPPGYILLDDNRSCQDINECEHRNHTCNL--QQTCYNLQGGFKCI 315



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 61/236 (25%), Positives = 88/236 (37%), Gaps = 68/236 (28%)

Query: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNG--VCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
            C+ G+  D +  +CVDVDEC  +S+  N   +C NT GGY C+CT    Y   + QCL  
Sbjct: 113  CRFGYQMDESN-QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG--YWLLEGQCLDI 169

Query: 1079 EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH 1138
            +E                  G C              C      +   C P         
Sbjct: 170  DECRY---------------GYC-----------QQLCANVPGSYSCTCNP--------- 194

Query: 1139 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPG 1194
                               G    ++  S +D +EC     CV   CV   G  +C C  
Sbjct: 195  -------------------GFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDP 234

Query: 1195 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
            G++L+     C D+DEC   +    LC+ E CVN  G++ C C  G+     + +C
Sbjct: 235  GYELEEDGVHCSDMDEC---SFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSC 286



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 58/211 (27%), Positives = 78/211 (36%), Gaps = 30/211 (14%)

Query: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPE--RRD-VCWSQRGEDGMCAGPLA 1106
            +C  + G  +  CT   +      QCL  +E    PE  R D +C +Q G  G    P  
Sbjct: 15   LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNG--GYLCIPRT 72

Query: 1107 GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLG-KPPRDED 1165
             P            RG  +     P  G         S  N    + PL+       DE 
Sbjct: 73   NPVY----------RGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDES 122

Query: 1166 SSEEDSDECRCVSGRCVP------RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGL 1219
            +   D DEC   S +C P        GG  C C  G+ L     +C+DIDECR       
Sbjct: 123  NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRY-----G 175

Query: 1220 LCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
             C+ + C N  GS+ C C  GF  +    +C
Sbjct: 176  YCQ-QLCANVPGSYSCTCNPGFTLNEDGRSC 205



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 15/104 (14%)

Query: 295 PGLTKQED--CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNST 351
           PG T  ED   C  +     ++ C          VQ      G     C  GY+   +  
Sbjct: 194 PGFTLNEDGRSCQDVNECATENPC----------VQTCVNTYGSFICRCDPGYELEEDGV 243

Query: 352 HCQDINECAMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           HC D++EC+    +C+H +C+N PG+Y C CPPG+ L      C
Sbjct: 244 HCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 12/99 (12%)

Query: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
           G     C  GY  L    C DI+EC   G C+   C N PGSY C C PG +L      C
Sbjct: 149 GGYTCSCTDGYWLLEG-QCLDIDECRY-GYCQQL-CANVPGSYSCTCNPGFTLNEDGRSC 205

Query: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
                ++ + C    + E+ C           +C C  G
Sbjct: 206 -----QDVNEC----ATENPCVQTCVNTYGSFICRCDPG 235



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 23/117 (19%)

Query: 295 PGLTKQED---CCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350
           PG   +ED   C      ++ +  C H+C       V +PG         CP GY  L+ 
Sbjct: 234 PGYELEEDGVHCSDMDECSFSEFLCQHEC-------VNQPGTYF----CSCPPGYILLDD 282

Query: 351 TH-CQDINECAMPG-VCR-HGDCLNNPGSYRCVCP-----PGHSLGPSRTQCIADKP 399
              CQDINEC      C     C N  G ++C+ P     P   +  +R  C A+ P
Sbjct: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)

Query: 341 CPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCVCPPGHSL 387
           C  GY+   S  C D++ECA     C     C+N  G Y C C  G+ L
Sbjct: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL 161


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.139    0.474 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,636,869
Number of Sequences: 37866
Number of extensions: 4728830
Number of successful extensions: 38887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 221
Number of HSP's successfully gapped in prelim test: 666
Number of HSP's that attempted gapping in prelim test: 21166
Number of HSP's gapped (non-prelim): 8423
length of query: 1256
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1142
effective length of database: 13,930,794
effective search space: 15908966748
effective search space used: 15908966748
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.