Search of human proteins with 183396780

Search of human proteins with 183396780

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
         (914 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|183396780 ubiquitin specific protease 20 [Homo sapiens]           1884   0.0  
gi|183397136 ubiquitin specific protease 20 [Homo sapiens]           1884   0.0  
gi|183397134 ubiquitin specific protease 20 [Homo sapiens]           1884   0.0  
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]  1115   0.0  
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]  1115   0.0  
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   949   0.0  
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  132   2e-30
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]            130   7e-30
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]            130   7e-30
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]            130   7e-30
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   125   2e-28
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   125   2e-28
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                121   3e-27
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]           116   1e-25
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]        115   2e-25
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]             115   2e-25
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]    112   1e-24
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]    112   1e-24
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]   110   8e-24
gi|148612811 ubiquitin specific protease 43 [Homo sapiens]            110   8e-24
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]             108   2e-23
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]             108   2e-23
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]            105   1e-22
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]            104   4e-22
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]                103   1e-21
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]                103   1e-21
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                   96   2e-19
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              87   5e-17
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]    87   7e-17
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]              87   7e-17

>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 1884 bits (4880), Expect = 0.0
 Identities = 914/914 (100%), Positives = 914/914 (100%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH
Sbjct: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120
           STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK
Sbjct: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120

Query: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180
           AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV
Sbjct: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180

Query: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240
           RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
Sbjct: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240

Query: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300
           DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR
Sbjct: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300

Query: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360
           GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ
Sbjct: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360

Query: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420
           PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS
Sbjct: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420

Query: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP
Sbjct: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480

Query: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540
           GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE
Sbjct: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540

Query: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600
           DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN
Sbjct: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600

Query: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660
           SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD
Sbjct: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660

Query: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720
           DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF
Sbjct: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720

Query: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780
           NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC
Sbjct: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780

Query: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840
           SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP
Sbjct: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840

Query: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900
           GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN
Sbjct: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900

Query: 901 LHGEQKIEAETRAV 914
           LHGEQKIEAETRAV
Sbjct: 901 LHGEQKIEAETRAV 914


>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 1884 bits (4880), Expect = 0.0
 Identities = 914/914 (100%), Positives = 914/914 (100%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH
Sbjct: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120
           STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK
Sbjct: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120

Query: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180
           AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV
Sbjct: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180

Query: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240
           RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
Sbjct: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240

Query: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300
           DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR
Sbjct: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300

Query: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360
           GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ
Sbjct: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360

Query: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420
           PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS
Sbjct: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420

Query: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP
Sbjct: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480

Query: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540
           GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE
Sbjct: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540

Query: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600
           DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN
Sbjct: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600

Query: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660
           SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD
Sbjct: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660

Query: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720
           DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF
Sbjct: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720

Query: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780
           NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC
Sbjct: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780

Query: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840
           SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP
Sbjct: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840

Query: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900
           GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN
Sbjct: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900

Query: 901 LHGEQKIEAETRAV 914
           LHGEQKIEAETRAV
Sbjct: 901 LHGEQKIEAETRAV 914


>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 1884 bits (4880), Expect = 0.0
 Identities = 914/914 (100%), Positives = 914/914 (100%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH
Sbjct: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120
           STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK
Sbjct: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK 120

Query: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180
           AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV
Sbjct: 121 AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV 180

Query: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240
           RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
Sbjct: 181 RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM 240

Query: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300
           DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR
Sbjct: 241 DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR 300

Query: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360
           GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ
Sbjct: 301 GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ 360

Query: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420
           PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS
Sbjct: 361 PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS 420

Query: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP
Sbjct: 421 YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480

Query: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540
           GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE
Sbjct: 481 GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE 540

Query: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600
           DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN
Sbjct: 541 DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN 600

Query: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660
           SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD
Sbjct: 601 SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD 660

Query: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720
           DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF
Sbjct: 661 DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF 720

Query: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780
           NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC
Sbjct: 721 NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC 780

Query: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840
           SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP
Sbjct: 781 SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP 840

Query: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900
           GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN
Sbjct: 841 GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN 900

Query: 901 LHGEQKIEAETRAV 914
           LHGEQKIEAETRAV
Sbjct: 901 LHGEQKIEAETRAV 914


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score = 1115 bits (2884), Expect = 0.0
 Identities = 553/927 (59%), Positives = 689/927 (74%), Gaps = 29/927 (3%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           M   R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+  C YVGCGES  DH
Sbjct: 32  MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
           STIH+Q  KH LTVNLTT R+WCYAC KEVFL+++L      P +    +  E   QD  
Sbjct: 92  STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151

Query: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
            PS+  LK   +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211

Query: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
           FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP  VVPT+L  GIK VNP FRGY+QQD
Sbjct: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271

Query: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
            QEFLRCLMD LHEELKE V+         D  +  T+E  E D+S S+ +F SC+S  +
Sbjct: 272 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 326

Query: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
           SDR E +   R       ET +LI D+   +   K+  K++  +   +  +  + D+D D
Sbjct: 327 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386

Query: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
             +    L++Q         R+S      E   D H    S P     +   + +LS+SP
Sbjct: 387 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 440

Query: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
           P++  +   +AP +  KKAQ  S   R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS 
Sbjct: 441 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 497

Query: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
           T+ETFQDLSLPIPGKEDLAKLHS+ +     K G+CG++YA QGW+AF +EY++RFVVSC
Sbjct: 498 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 557

Query: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
            PSWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV   PEILCIHLK
Sbjct: 558 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 617

Query: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
           RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+  +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 618 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 677

Query: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
           C+N +N  WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L  + EPSL
Sbjct: 678 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 737

Query: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
           L+FY+SR+WLNKF TFAEPGPI+N  FLC HGG+PP K  YI+DLV++LPQN+W++LY+R
Sbjct: 738 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 797

Query: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
           +GGGPAVNHLY+C  CQ+E E + KRR+ E++ FI+LN+AFQ E+SP   YCISMQWFRE
Sbjct: 798 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 857

Query: 828 WEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIA 887
           WE+FVKGKD +PPGPIDN++IA  K  G+V L+QGAD GQISEETW +L S+YGGGPE+ 
Sbjct: 858 WESFVKGKDGDPPGPIDNTKIAVTK-CGNVMLRQGADSGQISEETWNFLQSIYGGGPEVI 916

Query: 888 IRQSVAQPLGPENLHGEQKIEAETRAV 914
           +R  V   + P+ L  E+KIE ETR++
Sbjct: 917 LRPPVVH-VDPDILQAEEKIEVETRSL 942


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score = 1115 bits (2884), Expect = 0.0
 Identities = 553/927 (59%), Positives = 689/927 (74%), Gaps = 29/927 (3%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           M   R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+  C YVGCGES  DH
Sbjct: 1   MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
           STIH+Q  KH LTVNLTT R+WCYAC KEVFL+++L      P +    +  E   QD  
Sbjct: 61  STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120

Query: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
            PS+  LK   +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180

Query: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
           FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP  VVPT+L  GIK VNP FRGY+QQD
Sbjct: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240

Query: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
            QEFLRCLMD LHEELKE V+         D  +  T+E  E D+S S+ +F SC+S  +
Sbjct: 241 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 295

Query: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
           SDR E +   R       ET +LI D+   +   K+  K++  +   +  +  + D+D D
Sbjct: 296 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 355

Query: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
             +    L++Q         R+S      E   D H    S P     +   + +LS+SP
Sbjct: 356 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 409

Query: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
           P++  +   +AP +  KKAQ  S   R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS 
Sbjct: 410 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 466

Query: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
           T+ETFQDLSLPIPGKEDLAKLHS+ +     K G+CG++YA QGW+AF +EY++RFVVSC
Sbjct: 467 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 526

Query: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
            PSWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV   PEILCIHLK
Sbjct: 527 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 586

Query: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
           RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+  +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 587 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 646

Query: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
           C+N +N  WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L  + EPSL
Sbjct: 647 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 706

Query: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
           L+FY+SR+WLNKF TFAEPGPI+N  FLC HGG+PP K  YI+DLV++LPQN+W++LY+R
Sbjct: 707 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 766

Query: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
           +GGGPAVNHLY+C  CQ+E E + KRR+ E++ FI+LN+AFQ E+SP   YCISMQWFRE
Sbjct: 767 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 826

Query: 828 WEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIA 887
           WE+FVKGKD +PPGPIDN++IA  K  G+V L+QGAD GQISEETW +L S+YGGGPE+ 
Sbjct: 827 WESFVKGKDGDPPGPIDNTKIAVTK-CGNVMLRQGADSGQISEETWNFLQSIYGGGPEVI 885

Query: 888 IRQSVAQPLGPENLHGEQKIEAETRAV 914
           +R  V   + P+ L  E+KIE ETR++
Sbjct: 886 LRPPVVH-VDPDILQAEEKIEVETRSL 911


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  949 bits (2454), Expect = 0.0
 Identities = 477/819 (58%), Positives = 597/819 (72%), Gaps = 35/819 (4%)

Query: 1   MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
           M   R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+  C YVGCGES  DH
Sbjct: 32  MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91

Query: 61  STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
           STIH+Q  KH LTVNLTT R+WCYAC KEVFL+++L      P +    +  E   QD  
Sbjct: 92  STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151

Query: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
            PS+  LK   +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211

Query: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
           FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP  VVPT+L  GIK VNP FRGY+QQD
Sbjct: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271

Query: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
            QEFLRCLMD LHEELKE V+         D  +  T+E  E D+S S+ +F SC+S  +
Sbjct: 272 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 326

Query: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
           SDR E +   R       ET +LI D+   +   K+  K++  +   +  +  + D+D D
Sbjct: 327 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386

Query: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
             +    L++Q         R+S      E   D H    S P     +   + +LS+SP
Sbjct: 387 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 440

Query: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
           P++  +   +AP +  KKAQ  S   R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS 
Sbjct: 441 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 497

Query: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
           T+ETFQDLSLPIPGKEDLAKLHS+ +     K G+CG++YA QGW+AF +EY++      
Sbjct: 498 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK------ 551

Query: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
             SWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV   PEILCIHLK
Sbjct: 552 --SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 609

Query: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
           RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+  +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 610 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 669

Query: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
           C+N +N  WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L  + EPSL
Sbjct: 670 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 729

Query: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
           L+FY+SR+WLNKF TFAEPGPI+N  FLC HGG+PP K  YI+DLV++LPQN+W++LY+R
Sbjct: 730 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 789

Query: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNK 806
           +GGGPAVNHLY+C  CQ+E E + KRR+ E++ FI++ K
Sbjct: 790 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 18/102 (17%)

Query: 788 EALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSR 847
           EA  +RRRI        +      E   + + IS QW  +++ F +      PGPI N+ 
Sbjct: 710 EAQKERRRI--------SNLLNIMEPSLLQFYISRQWLNKFKTFAE------PGPISNND 755

Query: 848 IAQVKGSGHVQLKQGADYG---QISEETWTYLNSLYGGGPEI 886
              + G G    K G        + +  W  L S YGGGP +
Sbjct: 756 FLCIHG-GVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score =  132 bits (331), Expect = 2e-30
 Identities = 87/273 (31%), Positives = 130/273 (47%), Gaps = 46/273 (16%)

Query: 420 SYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPI 479
           S +L++   LSA S +       +V++ IF G + + V CL C   S   + F DLSL I
Sbjct: 286 SAILQENSTLSA-SNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDI 344

Query: 480 PGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTL 539
           P +       S   +N                                      GPV +L
Sbjct: 345 PSQ--FRSKRSKNQEN--------------------------------------GPVCSL 364

Query: 540 EDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKI 599
            DCL +F   +EL    +Y C +CKK +   K   + +LP++LC+HLKRF        K+
Sbjct: 365 RDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKV 424

Query: 600 NSHVSFPLEGLDLRPFLAKECTS--QITTYDLLSVICHHGT-AGSGHYIAYCQNVINGQW 656
           +++V FPL GLD++ +L +   S  +   YDL +V+ HHG+  GSGHY AY  +   G+W
Sbjct: 425 DTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATH--EGRW 482

Query: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEA 689
           + F+D  VT   E  V  A+ Y+LFY +   +A
Sbjct: 483 FHFNDSTVTLTDEETVVKAKAYILFYVEHQAKA 515



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 74/283 (26%), Positives = 119/283 (42%), Gaps = 50/283 (17%)

Query: 8   CPHLDSIGEVTKEDLLLKS---KGTCQSCGVTGPNLWACLQVACPYVGCGESFADHS--- 61
           CPHL S   +  +     +      C S   +  + W CL   C  V CG     H+   
Sbjct: 3   CPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCL--TCSSVHCGRYVNGHAKKH 60

Query: 62  --------TIHAQAKK-----HNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFS 108
                   T H +++K     H + ++ +++  +CY C+  V  + +L     G   K  
Sbjct: 61  YEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKL-----GLVQKVR 115

Query: 109 EQDSPPPSHPLKAVPIAVADEGESESEDDDL-KPRG------LTGMKNLGNSCYMNAALQ 161
           E      +    A         E+ + +  L K  G       TG++NLGN+C+MNA LQ
Sbjct: 116 EHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQ 175

Query: 162 ALSNCPPLTQFFLECGGLVRTDKKPA----------------LCKSYQKLVSEVWHKKRP 205
           +LSN      +F E   +   + K A                L + ++K +  +W   + 
Sbjct: 176 SLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQT 235

Query: 206 SYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
           ++  P SL + +  + P FRGY QQD  EF+R L+D LH EL+
Sbjct: 236 AFS-PESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQ 277


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  130 bits (326), Expect = 7e-30
 Identities = 74/248 (29%), Positives = 117/248 (47%), Gaps = 53/248 (21%)

Query: 435  RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
            ++ +Q   S+I  +F G   S VQCLTC + S T E F  LSLP+               
Sbjct: 912  QKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL--------------- 956

Query: 495  NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
               A    C                                  TL+DCL  F   ++L  
Sbjct: 957  ---ASTSKC----------------------------------TLQDCLRLFSKEEKLTD 979

Query: 555  DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
            +N + C  C+  R+ +K  ++ +LP +L +HLKRF ++  +  K+ + V FPLE LDL  
Sbjct: 980  NNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQ 1039

Query: 615  FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
            ++     + +  Y+L SV  H+G    GHY AYC+N    +W++FDD  V+++  + V++
Sbjct: 1040 YVIGP-KNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKS 1098

Query: 675  AEGYVLFY 682
            +  Y+LFY
Sbjct: 1099 SAAYILFY 1106



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 7/112 (6%)

Query: 144 LTGMKNLGNSCYMNAALQALSNCPPLTQFF-LEC--GGLVRTD---KKPALCKSYQKLVS 197
           LTG++NLGN+CYMN+ LQ L N P L  +F   C    + R++    K  + + +  ++ 
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835

Query: 198 EVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKE 249
            +W   +  Y+ P      I  +N  F GY+QQD+QE L  LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  130 bits (326), Expect = 7e-30
 Identities = 74/248 (29%), Positives = 117/248 (47%), Gaps = 53/248 (21%)

Query: 435  RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
            ++ +Q   S+I  +F G   S VQCLTC + S T E F  LSLP+               
Sbjct: 912  QKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL--------------- 956

Query: 495  NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
               A    C                                  TL+DCL  F   ++L  
Sbjct: 957  ---ASTSKC----------------------------------TLQDCLRLFSKEEKLTD 979

Query: 555  DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
            +N + C  C+  R+ +K  ++ +LP +L +HLKRF ++  +  K+ + V FPLE LDL  
Sbjct: 980  NNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQ 1039

Query: 615  FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
            ++     + +  Y+L SV  H+G    GHY AYC+N    +W++FDD  V+++  + V++
Sbjct: 1040 YVIGP-KNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKS 1098

Query: 675  AEGYVLFY 682
            +  Y+LFY
Sbjct: 1099 SAAYILFY 1106



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 7/112 (6%)

Query: 144 LTGMKNLGNSCYMNAALQALSNCPPLTQFF-LEC--GGLVRTD---KKPALCKSYQKLVS 197
           LTG++NLGN+CYMN+ LQ L N P L  +F   C    + R++    K  + + +  ++ 
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835

Query: 198 EVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKE 249
            +W   +  Y+ P      I  +N  F GY+QQD+QE L  LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  130 bits (326), Expect = 7e-30
 Identities = 74/248 (29%), Positives = 117/248 (47%), Gaps = 53/248 (21%)

Query: 435  RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
            ++ +Q   S+I  +F G   S VQCLTC + S T E F  LSLP+               
Sbjct: 912  QKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL--------------- 956

Query: 495  NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
               A    C                                  TL+DCL  F   ++L  
Sbjct: 957  ---ASTSKC----------------------------------TLQDCLRLFSKEEKLTD 979

Query: 555  DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
            +N + C  C+  R+ +K  ++ +LP +L +HLKRF ++  +  K+ + V FPLE LDL  
Sbjct: 980  NNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQ 1039

Query: 615  FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
            ++     + +  Y+L SV  H+G    GHY AYC+N    +W++FDD  V+++  + V++
Sbjct: 1040 YVIGP-KNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKS 1098

Query: 675  AEGYVLFY 682
            +  Y+LFY
Sbjct: 1099 SAAYILFY 1106



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 7/112 (6%)

Query: 144 LTGMKNLGNSCYMNAALQALSNCPPLTQFF-LEC--GGLVRTD---KKPALCKSYQKLVS 197
           LTG++NLGN+CYMN+ LQ L N P L  +F   C    + R++    K  + + +  ++ 
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835

Query: 198 EVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKE 249
            +W   +  Y+ P      I  +N  F GY+QQD+QE L  LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  125 bits (313), Expect = 2e-28
 Identities = 82/252 (32%), Positives = 118/252 (46%), Gaps = 52/252 (20%)

Query: 435 RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
           R+  +R  S I D+F G + S + C  C   ST  + F DLSLPI               
Sbjct: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236

Query: 495 NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
                        A +G+                      P VTL DC+  F   D L G
Sbjct: 237 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 261

Query: 555 DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
           D   +C RC+  +  +K   + R P+IL +HLKRF    + + K+ + V+FPL  LDLR 
Sbjct: 262 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 321

Query: 615 FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
           F A E T+    Y+L +V  H GT   GHY AYC++   G+W+ F+D  VT +  + V+ 
Sbjct: 322 F-ASENTNH-AVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 379

Query: 675 AEGYVLFYRKSS 686
           ++ Y+LFY  +S
Sbjct: 380 SDAYLLFYELAS 391



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 44/112 (39%), Positives = 60/112 (53%), Gaps = 8/112 (7%)

Query: 142 RGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPALCKSYQKL 195
           +GL G++NLGN+C+MN+ LQ LSN   L  + L+   L   D         AL + + KL
Sbjct: 55  QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQ--RLYMRDLHHGSNAHTALVEEFAKL 112

Query: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           +  +W       V P+     I+   P F GY QQD QEFLR L+D LH E+
Sbjct: 113 IQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV 164


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score =  125 bits (313), Expect = 2e-28
 Identities = 82/252 (32%), Positives = 118/252 (46%), Gaps = 52/252 (20%)

Query: 435 RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
           R+  +R  S I D+F G + S + C  C   ST  + F DLSLPI               
Sbjct: 401 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 445

Query: 495 NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
                        A +G+                      P VTL DC+  F   D L G
Sbjct: 446 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 470

Query: 555 DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
           D   +C RC+  +  +K   + R P+IL +HLKRF    + + K+ + V+FPL  LDLR 
Sbjct: 471 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 530

Query: 615 FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
           F A E T+    Y+L +V  H GT   GHY AYC++   G+W+ F+D  VT +  + V+ 
Sbjct: 531 F-ASENTNH-AVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 588

Query: 675 AEGYVLFYRKSS 686
           ++ Y+LFY  +S
Sbjct: 589 SDAYLLFYELAS 600



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 44/112 (39%), Positives = 60/112 (53%), Gaps = 8/112 (7%)

Query: 142 RGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPALCKSYQKL 195
           +GL G++NLGN+C+MN+ LQ LSN   L  + L+   L   D         AL + + KL
Sbjct: 264 QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQ--RLYMRDLHHGSNAHTALVEEFAKL 321

Query: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           +  +W       V P+     I+   P F GY QQD QEFLR L+D LH E+
Sbjct: 322 IQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV 373


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score =  121 bits (304), Expect = 3e-27
 Identities = 79/267 (29%), Positives = 114/267 (42%), Gaps = 45/267 (16%)

Query: 432 GSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSA 491
           G +         +I  IF G + S V C  C  VSTT++ F D+SL +PG          
Sbjct: 284 GKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSST------- 336

Query: 492 IYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADE 551
                P  PG+ G+    +  ++                       TL DCL  F   + 
Sbjct: 337 --PFWPLSPGSEGNVVNGESHVS--------------------GTTTLTDCLRRFTRPEH 374

Query: 552 LKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLD 611
           L       C  C   +   K   + +LP + C HLKRF H      KI ++VSFPLE LD
Sbjct: 375 LGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LD 433

Query: 612 LRPFLAKECTSQI--------------TTYDLLSVICHHGTAGSGHYIAYCQNVINGQWY 657
           + PF+A    S++                Y L +V+ H GT  SGHY ++ +     QW+
Sbjct: 434 MTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQ-HKDQWF 492

Query: 658 EFDDQYVTEVHETVVQNAEGYVLFYRK 684
           + DD  +T+     V ++EGY+LFY K
Sbjct: 493 KCDDAIITKASIKDVLDSEGYLLFYHK 519



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 65/228 (28%), Positives = 96/228 (42%), Gaps = 20/228 (8%)

Query: 30  CQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKE 89
           C  CGV    L +CL   C + GC      H   HA+AK+HNL ++L    ++C+ C+  
Sbjct: 63  CHVCGVHLNRLHSCLY--CVFFGCFTKKHIHE--HAKAKRHNLAIDLMYGGIYCFLCQDY 118

Query: 90  VF---------LEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLK 140
           ++          EQR A  + G   KFS  +      P K   + +        +     
Sbjct: 119 IYDKDMEIIAKEEQRKAWKMQGVGEKFSTWE------PTKR-ELELLKHNPKRRKITSNC 171

Query: 141 PRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVW 200
             GL G+ NLGN+C+MN  +QAL++ P L  FFL            +        + + +
Sbjct: 172 TIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEF 231

Query: 201 HKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
           +    S  +P  L H +        GY QQD  EFL   +D LH   K
Sbjct: 232 YSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK 279


>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
          Length = 1352

 Score =  116 bits (290), Expect = 1e-25
 Identities = 68/198 (34%), Positives = 95/198 (47%), Gaps = 23/198 (11%)

Query: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
           TL  C   +   + L  D+ + C  CK+L+ G     +  LP++L IHLKRFR E     
Sbjct: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656

Query: 598 KINSHVSFPLEGLDLRPFLAKECTSQITT---------------------YDLLSVICHH 636
           K+ + V FPL GLD+ P + K   S  +                      YDL +V  HH
Sbjct: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716

Query: 637 GTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQV 696
           GT   GHY AYC+N ++G WY FDD  V ++ E  V     Y+LFY++ +  A+      
Sbjct: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774

Query: 697 VSLAAMREPSLLRFYVSR 714
            S+A     SL   +VSR
Sbjct: 775 SSVAGSTSSSLCEHWVSR 792



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 33/185 (17%)

Query: 112 SPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
           +PPP  P  A P   A   E           G+ G++N GN+C+MNA LQ LSN    T+
Sbjct: 103 TPPPCPPPPASPAPPACAAEPVP--------GVAGLRNHGNTCFMNATLQCLSN----TE 150

Query: 172 FFLECGGLVR----------TDKKPA--LCKSYQKLVSEVWHKKRPSYVVPTSLSHG--- 216
            F E   L +            ++PA    +   ++  ++ H  R  + +  +  H    
Sbjct: 151 LFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDF 210

Query: 217 --IKLVNPM-FRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273
             I   N + +RG +Q D QEFL  L+D++HE+L   V  +    +      S+TD   E
Sbjct: 211 KTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQS---GQPPLKPPSETDMMPE 267

Query: 274 GDRSP 278
           G   P
Sbjct: 268 GPSFP 272


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score =  115 bits (288), Expect = 2e-25
 Identities = 76/272 (27%), Positives = 118/272 (43%), Gaps = 46/272 (16%)

Query: 444 VISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGAC 503
           +I  IF G + S V C  C  VSTT++   D+SL +PG        ++ +   P +  + 
Sbjct: 198 IIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS------CTSFWPMSPGRESSV 251

Query: 504 GDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERC 563
                  G                        + TL DCL  F   + L       C  C
Sbjct: 252 NGESHIPG------------------------ITTLTDCLRRFTRPEHLGSSAKIKCGSC 287

Query: 564 KKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQ 623
           +  +   K   + +LP + C H KRF H      KI +++SFPLE LD+ PF+A    S+
Sbjct: 288 QSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPFMASSKESR 346

Query: 624 I--------------TTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHE 669
           +                Y L +V+ H GT  SGHY ++ ++    QW++ DD  +T+   
Sbjct: 347 MNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRH-HKDQWFKCDDAVITKASI 405

Query: 670 TVVQNAEGYVLFYRKSSEEAMRERQQVVSLAA 701
             V ++EGY+LFY K   E   E+ + ++  A
Sbjct: 406 KDVLDSEGYLLFYHKQVLEHESEKVKEMNTQA 437



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 43/116 (37%), Positives = 54/116 (46%), Gaps = 4/116 (3%)

Query: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCK--SYQKLVSEVW 200
           GL G+ NLGN+C+MN  +QAL++ P L  FFL           P LC       L  E+ 
Sbjct: 76  GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEM-PSPELCLVCEMSSLFREL- 133

Query: 201 HKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVA 256
           +   PS  VP  L H + +      GY QQD  EFL   +D LH   K   V   A
Sbjct: 134 YSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAA 189


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score =  115 bits (288), Expect = 2e-25
 Identities = 82/272 (30%), Positives = 110/272 (40%), Gaps = 44/272 (16%)

Query: 430 SAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLH 489
           S G           +I  IF G + S V C  C  VSTT++   D+SL +PG    A   
Sbjct: 469 SGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS--CATFD 526

Query: 490 SAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAA 549
           S   QN               G                        + +L DCL  F   
Sbjct: 527 S---QNPERADSTVSRDDHIPG------------------------IPSLTDCLQWFTRP 559

Query: 550 DELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEG 609
           + L       C  C+  +   K   + +LP + C HLKRF H      KIN+ +SFPLE 
Sbjct: 560 EHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE- 618

Query: 610 LDLRPFLAK-------------ECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
           LD+ PFLA              +C      Y L +VI HHGT  SGHY ++ +     QW
Sbjct: 619 LDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQ-KDQW 677

Query: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
           +  DD  +T+     +  +EGY+LFY K   E
Sbjct: 678 FSCDDAIITKATIEDLLYSEGYLLFYHKQGLE 709



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/242 (27%), Positives = 102/242 (42%), Gaps = 32/242 (13%)

Query: 30  CQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKE 89
           C  C      L +CL  +C + GC      H   HA+ K+H+L V+L    ++C+ C+  
Sbjct: 236 CHVCSTHMNRLHSCL--SCVFFGCFTEKHIHK--HAETKQHHLAVDLYHGVIYCFMCKDY 291

Query: 90  VF----------LEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDL 139
           V+           ++++   L  +S+  S Q         K            E E   +
Sbjct: 292 VYDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCET-----KEQEPKLV 346

Query: 140 KPR-----------GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL-ECGGLVRTDKKPA 187
           KP+           GL G+ NLGN+C+MN  +QAL++ P L  FFL +    + T     
Sbjct: 347 KPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLC 406

Query: 188 LCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           L      L   ++   R  + +P  L H I +      GY QQD  EFL  ++D LH   
Sbjct: 407 LVCEMSSLFHAMYSGSRTPH-IPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHS 465

Query: 248 KE 249
           K+
Sbjct: 466 KD 467


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score =  112 bits (281), Expect = 1e-24
 Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)

Query: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
           V L DC+  F   + L   + + C  CKK +   K   +  LP+IL +HLKRF +   + 
Sbjct: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835

Query: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
            K+++ V FP+ GL++  F+    +++   YDL++V  H+G  G GHY AY +N +NG+W
Sbjct: 836 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894

Query: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
           Y FDD  V+   E  +     YVLFY++  +E
Sbjct: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 926



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196
           GL G+ NLGN+C+MN+ALQ LSN  PLT +FL  E    +  D     K  + ++Y +L+
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359

Query: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
            ++W   R ++V P      +    P F GY QQD+QE L  L+D LHE+L
Sbjct: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 409



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)

Query: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866
           Y I  +WF++W+ +V          G+ N  PGPIDNS +     S  ++  L    DY 
Sbjct: 35  YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94

Query: 867 QISEETWTYLNSLYG 881
            +  E W  L + YG
Sbjct: 95  LVPTEAWNKLLNWYG 109



 Score = 37.4 bits (85), Expect = 0.064
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484
           R  SVI D F G   S + C  C +VS T + F  L+LP+P K+D
Sbjct: 442 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score =  112 bits (281), Expect = 1e-24
 Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)

Query: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
           V L DC+  F   + L   + + C  CKK +   K   +  LP+IL +HLKRF +   + 
Sbjct: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788

Query: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
            K+++ V FP+ GL++  F+    +++   YDL++V  H+G  G GHY AY +N +NG+W
Sbjct: 789 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847

Query: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
           Y FDD  V+   E  +     YVLFY++  +E
Sbjct: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 879



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196
           GL G+ NLGN+C+MN+ALQ LSN  PLT +FL  E    +  D     K  + ++Y +L+
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312

Query: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
            ++W   R ++V P      +    P F GY QQD+QE L  L+D LHE+L
Sbjct: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 362



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)

Query: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866
           Y I  +WF++W+ +V          G+ N  PGPIDNS +     S  ++  L    DY 
Sbjct: 35  YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94

Query: 867 QISEETWTYLNSLYG 881
            +  E W  L + YG
Sbjct: 95  LVPTEAWNKLLNWYG 109



 Score = 37.4 bits (85), Expect = 0.064
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484
           R  SVI D F G   S + C  C +VS T + F  L+LP+P K+D
Sbjct: 395 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439


>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
          Length = 1035

 Score =  110 bits (274), Expect = 8e-24
 Identities = 90/379 (23%), Positives = 162/379 (42%), Gaps = 78/379 (20%)

Query: 539 LEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKR--FRHEVMYS 596
           L DC++ F   ++L+GDN Y CE C+  +N  +  ++L LP  L + L R  F  +  + 
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308

Query: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHG-TAGSGHYIAYCQNVINGQ 655
            K+N+++ F  E LD+ P++  +  S +  Y+L +V+ H G +A SGHYIA+ ++  +G+
Sbjct: 309 KKLNTYIGFS-EILDMEPYVEHKGGSYV--YELSAVLIHRGVSAYSGHYIAHVKDPQSGE 365

Query: 656 WYEFDDQYVTEVHETVVQ--------------------------NAEGYVLFYRKSSEEA 689
           WY+F+D+ + ++    +Q                          +   Y+L YR  ++E 
Sbjct: 366 WYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEK 425

Query: 690 MRERQQV-------------------VSLAAMREPSLLR--------------------- 709
                QV                   + +A MR+ S+ +                     
Sbjct: 426 PNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEP 485

Query: 710 -FYVSREWLNKFNTFAEP-GPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
             +VS EWL K+   + P  PI N   LCSH  + P K      ++  + +   +  Y+R
Sbjct: 486 YEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPDKI----SIMKRISEYAADIFYSR 541

Query: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
           +GGGP +    +C  C VE   + + +    + +  +N   +A       + +     R 
Sbjct: 542 YGGGPRLTVKALCKECVVERCRILRLKNQLNEDYKTVNNLLKAAVKGSDGFWVGKSSLRS 601

Query: 828 WEAFVKGKDNEPPGPIDNS 846
           W      + +E  G  + S
Sbjct: 602 WRQLALEQLDEQDGDAEQS 620



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 38/138 (27%), Positives = 56/138 (40%), Gaps = 22/138 (15%)

Query: 128 DEGESESEDDD----LKPRGLTGMKNLGNSCYMNAAL----------QALSNCP-PLTQF 172
           DE    + DD      K     G+ NLG +CY+N  L          QAL  CP   + +
Sbjct: 68  DENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDY 127

Query: 173 FLECGGLVRTDKKP-ALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
            L  G     D +P  +C+  Q L + + +  R  Y+ P+     + L         QQD
Sbjct: 128 MLGDGIQEEKDYEPQTICEHLQYLFALLQNSNR-RYIDPSGFVKALGLDTGQ-----QQD 181

Query: 232 TQEFLRCLMDQLHEELKE 249
            QEF +  M  L + L +
Sbjct: 182 AQEFSKLFMSLLEDTLSK 199


>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
          Length = 1123

 Score =  110 bits (274), Expect = 8e-24
 Identities = 58/169 (34%), Positives = 85/169 (50%), Gaps = 22/169 (13%)

Query: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
           TL++C   +   ++L  D+ + C  C+ L+ G+    +  LP+IL IHLKRF        
Sbjct: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600

Query: 598 KINSHVSFPLEGLDLRPFLAKECTSQIT----------------------TYDLLSVICH 635
           K+++ V FPL GL++ P +A+  TS                          YDL +V  H
Sbjct: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660

Query: 636 HGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
           HG    GHY AYC+N ++GQWY +DD  V  + E  V     Y+LFY+K
Sbjct: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 48/173 (27%), Positives = 71/173 (41%), Gaps = 26/173 (15%)

Query: 100 LLGSSSKFSEQDSPPPSHPLKA--------------VPIAVADEGESESED--------- 136
           LL   S+    DSPP   P                 VP A    GE              
Sbjct: 32  LLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPA 91

Query: 137 -DDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKL 195
            D  +P G  G+KN GN+C+MNA +Q LSN   L + FL  G       +  + +    L
Sbjct: 92  GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAAL 150

Query: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
           V  +W ++     +     + +      F+G +Q D  EFL  L+D++HE+L+
Sbjct: 151 VRALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  108 bits (270), Expect = 2e-23
 Identities = 78/253 (30%), Positives = 108/253 (42%), Gaps = 52/253 (20%)

Query: 435 RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
           +R  +R  S I D+F G + S ++C  C   STT E F DLSLPIP K            
Sbjct: 360 KRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKG----------- 408

Query: 495 NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
                                                F G  V+L DC   F   +EL+ 
Sbjct: 409 -------------------------------------FAGGKVSLRDCFNLFTKEEELES 431

Query: 555 DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
           +N   C+RC++     K   V R P IL +HL RF        K +  V FPL+ L L  
Sbjct: 432 ENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGD 491

Query: 615 FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
           F + +  S +  Y L ++  H G+   GHY A C+      W+ ++D  V+ V E  V +
Sbjct: 492 FASDKAGSPV--YQLYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVAS 547

Query: 675 AEGYVLFYRKSSE 687
           +EGYVLFY+   E
Sbjct: 548 SEGYVLFYQLMQE 560



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 17/158 (10%)

Query: 102 GSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPR------GLTGMKNLGNSCY 155
           G  + FS +  PP SH   +  +  A   E    DD +         G  G++NLGN+C+
Sbjct: 165 GPPTLFSIRTEPPASHG--SFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCF 222

Query: 156 MNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVV 209
           +NA LQ LS+  PL  F L      E  G  R  +   L +++  ++  +WH      V 
Sbjct: 223 LNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAFADVIGALWHPDSCEAVN 279

Query: 210 PTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           PT      +   P F GY+QQD QEFL+ LM++LH E+
Sbjct: 280 PTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEI 317


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  108 bits (270), Expect = 2e-23
 Identities = 78/253 (30%), Positives = 108/253 (42%), Gaps = 52/253 (20%)

Query: 435 RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494
           +R  +R  S I D+F G + S ++C  C   STT E F DLSLPIP K            
Sbjct: 360 KRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKG----------- 408

Query: 495 NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554
                                                F G  V+L DC   F   +EL+ 
Sbjct: 409 -------------------------------------FAGGKVSLRDCFNLFTKEEELES 431

Query: 555 DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614
           +N   C+RC++     K   V R P IL +HL RF        K +  V FPL+ L L  
Sbjct: 432 ENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGD 491

Query: 615 FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674
           F + +  S +  Y L ++  H G+   GHY A C+      W+ ++D  V+ V E  V +
Sbjct: 492 FASDKAGSPV--YQLYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVAS 547

Query: 675 AEGYVLFYRKSSE 687
           +EGYVLFY+   E
Sbjct: 548 SEGYVLFYQLMQE 560



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 17/158 (10%)

Query: 102 GSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPR------GLTGMKNLGNSCY 155
           G  + FS +  PP SH   +  +  A   E    DD +         G  G++NLGN+C+
Sbjct: 165 GPPTLFSIRTEPPASHG--SFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCF 222

Query: 156 MNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVV 209
           +NA LQ LS+  PL  F L      E  G  R  +   L +++  ++  +WH      V 
Sbjct: 223 LNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAFADVIGALWHPDSCEAVN 279

Query: 210 PTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           PT      +   P F GY+QQD QEFL+ LM++LH E+
Sbjct: 280 PTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEI 317


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score =  105 bits (263), Expect = 1e-22
 Identities = 53/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)

Query: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
           V L++C+  F   + L+ +N + C  CK+ +   K   +  LPEIL IHLKRF +     
Sbjct: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838

Query: 597 FKINSHVSFPLEGLDLRPFLAK---ECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVIN 653
            K+++ V FP+  LD   F+ +   E   ++  YDL++V  H+G    GHY  +  N  +
Sbjct: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898

Query: 654 GQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
           GQW+ FDD  V+ V+E  +++   YVLFY++
Sbjct: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 8/120 (6%)

Query: 135 EDDDLKPR-GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPA 187
           ED+D K + G+ G+ NLGN+C+MN+ALQ LSN P LT++FL    L   +       K  
Sbjct: 298 EDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGE 357

Query: 188 LCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
           + ++Y  LV + W     S +VP    + +      F GY Q D+QE L  L+D LHE+L
Sbjct: 358 IAEAYADLVKQAWSGHHRS-IVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDL 416



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)

Query: 818 YCISMQWFREWEAFVKGKDNEP---PGPIDNSRIAQVKGSGHVQ--LKQGADYGQISEET 872
           + +   W+++WEA+V+G D +    PG I+N+ + Q + +  ++  L +G DY  +    
Sbjct: 103 FLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAA 162

Query: 873 WTYLNSLYG 881
           W YL S YG
Sbjct: 163 WHYLVSWYG 171



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 18/43 (41%), Positives = 24/43 (55%)

Query: 438 EQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           ++R  SVI D F G   S + C  C  VS T + F  LS+P+P
Sbjct: 447 KRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score =  104 bits (259), Expect = 4e-22
 Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 1/150 (0%)

Query: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594
           P V L+DC+  F   ++L  ++ + C  CK+ +   K   +  LP +L +HLKRF +   
Sbjct: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814

Query: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVING 654
              K+++ V FP+  LD+  FL     +    Y+L++V  H+G  G GHY A+ +N  +G
Sbjct: 815 MRDKLDTLVDFPINDLDMSEFLINP-NAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873

Query: 655 QWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
           +WY FDD  V+   E  + +   YVLFY++
Sbjct: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/111 (43%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLV 196
           GL G+ NLGN+C+MN+A+Q LSN PPLT++FL      E         +  + KSY +L+
Sbjct: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317

Query: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
            ++W  K  SYV P +    +    P F GY QQD QE L  L+D LHE+L
Sbjct: 318 KQMWSGKF-SYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 415 VRMAPSYVLKKA-----QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTV 469
           +R  P   LK A     +V++  +     +R  S+I DIF G   S + C  C ++S T 
Sbjct: 370 IRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTF 429

Query: 470 ETFQDLSLPIPGKED 484
           + F  L+LP+P K++
Sbjct: 430 DPFCYLTLPLPMKKE 444



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 15/76 (19%)

Query: 818 YCISMQWFREWEAFV---------KGKDNEPPGPIDNSRIAQVKGSGHVQLKQ----GAD 864
           Y +  +WF++W+ +V          G  N  PGPIDNS +  +K      LK+      D
Sbjct: 31  YLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGL--LKDGDAQSLKEHLIDELD 88

Query: 865 YGQISEETWTYLNSLY 880
           Y  +  E W  L S Y
Sbjct: 89  YILLPTEGWNKLVSWY 104


>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score =  103 bits (256), Expect = 1e-21
 Identities = 82/273 (30%), Positives = 119/273 (43%), Gaps = 61/273 (22%)

Query: 433 SRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAI 492
           S+R+  ++  +V+++IF G +LS V CL CD  S T+E F DLSL  P +          
Sbjct: 453 SQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPER---------- 502

Query: 493 YQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADEL 552
           YQ         G   A+Q  L                         + + LA F   + L
Sbjct: 503 YQ-------CSGKDIASQPCL-------------------------VTEMLAKFTETEAL 530

Query: 553 KGDNMYSCERCKKLRN-----------GVKYCKVLRLPEILCIHLKRFRHEVMYSF-KIN 600
           +G  +Y C++C   R              K   +  LP++L +HLKRFR     +  KI 
Sbjct: 531 EG-KIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIG 589

Query: 601 SHVSFPLEGLDLRPFLAKECTSQITT----YDLLSVICHHGTA-GSGHYIAYCQNVINGQ 655
            HV F  E L++ P+  +E    +      YDL +V+ HHG   GSGHY AYC N   G 
Sbjct: 590 VHVGFE-EILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGF 648

Query: 656 WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
           W   +D  ++      V  A+ Y+LFY +   E
Sbjct: 649 WVHCNDSKLSMCTMDEVCKAQAYILFYTQRVTE 681



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 3/85 (3%)

Query: 6  DLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHA 65
          D C H+  +        L   K  C  C  T  ++WACL  +C +V CG    +H+  H 
Sbjct: 5  DTCKHVGQLQLAQDHSSLNPQKWHCVDCNTT-ESIWACL--SCSHVACGRYIEEHALKHF 61

Query: 66 QAKKHNLTVNLTTFRLWCYACEKEV 90
          Q   H + + +    ++CY C+  V
Sbjct: 62 QESSHPVALEVNEMYVFCYLCDDYV 86



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 1/76 (1%)

Query: 182 TDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMD 241
           T +  +LC     L   +W  K  + V P ++ H +  + P FRGYAQQD QEFL  L+D
Sbjct: 375 TSQYISLCHELHTLFQVMWSGKW-ALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLD 433

Query: 242 QLHEELKEPVVATVAL 257
           ++  EL+    +  AL
Sbjct: 434 KIQRELETTGTSLPAL 449



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 6/67 (8%)

Query: 115 PSHPLKAVPIAVADEGESESEDDDLKPR------GLTGMKNLGNSCYMNAALQALSNCPP 168
           P+ P K   ++ ++   S+   D    R      G+TG++NLGN+CYMN+ LQ LS+   
Sbjct: 237 PASPAKDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLI 296

Query: 169 LTQFFLE 175
             Q FL+
Sbjct: 297 FRQCFLK 303


>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score =  103 bits (256), Expect = 1e-21
 Identities = 82/273 (30%), Positives = 119/273 (43%), Gaps = 61/273 (22%)

Query: 433 SRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAI 492
           S+R+  ++  +V+++IF G +LS V CL CD  S T+E F DLSL  P +          
Sbjct: 453 SQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPER---------- 502

Query: 493 YQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADEL 552
           YQ         G   A+Q  L                         + + LA F   + L
Sbjct: 503 YQ-------CSGKDIASQPCL-------------------------VTEMLAKFTETEAL 530

Query: 553 KGDNMYSCERCKKLRN-----------GVKYCKVLRLPEILCIHLKRFRHEVMYSF-KIN 600
           +G  +Y C++C   R              K   +  LP++L +HLKRFR     +  KI 
Sbjct: 531 EG-KIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIG 589

Query: 601 SHVSFPLEGLDLRPFLAKECTSQITT----YDLLSVICHHGTA-GSGHYIAYCQNVINGQ 655
            HV F  E L++ P+  +E    +      YDL +V+ HHG   GSGHY AYC N   G 
Sbjct: 590 VHVGFE-EILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGF 648

Query: 656 WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
           W   +D  ++      V  A+ Y+LFY +   E
Sbjct: 649 WVHCNDSKLSMCTMDEVCKAQAYILFYTQRVTE 681



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 3/85 (3%)

Query: 6  DLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHA 65
          D C H+  +        L   K  C  C  T  ++WACL  +C +V CG    +H+  H 
Sbjct: 5  DTCKHVGQLQLAQDHSSLNPQKWHCVDCNTT-ESIWACL--SCSHVACGRYIEEHALKHF 61

Query: 66 QAKKHNLTVNLTTFRLWCYACEKEV 90
          Q   H + + +    ++CY C+  V
Sbjct: 62 QESSHPVALEVNEMYVFCYLCDDYV 86



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 1/76 (1%)

Query: 182 TDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMD 241
           T +  +LC     L   +W  K  + V P ++ H +  + P FRGYAQQD QEFL  L+D
Sbjct: 375 TSQYISLCHELHTLFQVMWSGKW-ALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLD 433

Query: 242 QLHEELKEPVVATVAL 257
           ++  EL+    +  AL
Sbjct: 434 KIQRELETTGTSLPAL 449



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 6/67 (8%)

Query: 115 PSHPLKAVPIAVADEGESESEDDDLKPR------GLTGMKNLGNSCYMNAALQALSNCPP 168
           P+ P K   ++ ++   S+   D    R      G+TG++NLGN+CYMN+ LQ LS+   
Sbjct: 237 PASPAKDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLI 296

Query: 169 LTQFFLE 175
             Q FL+
Sbjct: 297 FRQCFLK 303


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 59/163 (36%), Positives = 81/163 (49%), Gaps = 10/163 (6%)

Query: 538  TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFR-HEVMYS 596
            TL+ CL  F   + L  +  + C +CK+ R   K   + RLP +L + LKRF     ++ 
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118

Query: 597  FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQ- 655
             KIN  V FP+  LDL  F   +   Q+ +YDL +VI H+G    GHY A C  + N + 
Sbjct: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTA-CARLPNDRS 1177

Query: 656  -------WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMR 691
                   W  FDD  VT V E+ V     YVLFYR+ +    R
Sbjct: 1178 SQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVER 1220



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 51/164 (31%), Positives = 78/164 (47%), Gaps = 16/164 (9%)

Query: 112 SPPPS---HPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPP 168
           SP P+    P+   P++     E E E+  +   G TG+ NLGN+C+MN+ +Q+LSN   
Sbjct: 461 SPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRE 520

Query: 169 LTQFF--------LECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLV 220
           L  FF        +     + T  + A+   +  L+  +W     ++  P+ L   +   
Sbjct: 521 LRDFFHDRSFEAEINYNNPLGTGGRLAI--GFAVLLRALWKGTHHAF-QPSKLKAIVASK 577

Query: 221 NPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSD 264
              F GYAQ D QEF+  L+D LHE+L    +     TE  DSD
Sbjct: 578 ASQFTGYAQHDAQEFMAFLLDGLHEDLNR--IQNKPYTETVDSD 619



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 19/57 (33%), Positives = 32/57 (56%)

Query: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 483
           +V++  + +R + R  S I D+F G   S + C  C +VS T + F  L +P+P K+
Sbjct: 624 EVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 51/129 (39%), Positives = 71/129 (55%), Gaps = 9/129 (6%)

Query: 142 RGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDK------KPALCKSYQKL 195
           +G TG+ NLGN+C+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y  L
Sbjct: 529 KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDL 588

Query: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATV 255
           V E+W   + S V P  L   I    P F G+ QQD+QE L  L+D LHE+L    V   
Sbjct: 589 VQELWSGTQKS-VAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNR--VHEK 645

Query: 256 ALTEARDSD 264
              E +DSD
Sbjct: 646 PYVELKDSD 654



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 1/58 (1%)

Query: 627  YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
            Y+L ++ CH G    GHYI Y +N  N +WY ++D    E+H   +     Y+LFY +
Sbjct: 1312 YNLYAISCHSGILSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTDSAYILFYEQ 1368



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 30/80 (37%), Positives = 37/80 (46%)

Query: 537  VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
            + L+ CL AF + +EL    MY C +CK      K   + RLP  L IHLKRF+      
Sbjct: 1031 INLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQW 1090

Query: 597  FKINSHVSFPLEGLDLRPFL 616
             K    V F  E  D   FL
Sbjct: 1091 IKSQKIVRFLRESFDPSAFL 1110



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 19/42 (45%), Positives = 27/42 (64%)

Query: 439 QRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           +R RS+I D+F G + S V+C TC  +S   + F  LSLP+P
Sbjct: 671 RRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 712


>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
          Length = 485

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 46/138 (33%), Positives = 84/138 (60%), Gaps = 6/138 (4%)

Query: 539 LEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKR--FRHEVMYS 596
           L DC++ F   ++L+GDN Y CE C+  +N  +  ++L LP  L + L R  F  +  + 
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308

Query: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHG-TAGSGHYIAYCQNVINGQ 655
            K+N+++ F  E LD+ P++  +  S +  Y+L +V+ H G +A SGHYIA+ ++  +G+
Sbjct: 309 KKLNTYIGFS-EILDMEPYVEHKGGSYV--YELSAVLIHRGVSAYSGHYIAHVKDPQSGE 365

Query: 656 WYEFDDQYVTEVHETVVQ 673
           WY+F+D+ + ++    +Q
Sbjct: 366 WYKFNDEDIEKMEGKKLQ 383



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 38/138 (27%), Positives = 56/138 (40%), Gaps = 22/138 (15%)

Query: 128 DEGESESEDDD----LKPRGLTGMKNLGNSCYMNAAL----------QALSNCP-PLTQF 172
           DE    + DD      K     G+ NLG +CY+N  L          QAL  CP   + +
Sbjct: 68  DENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDY 127

Query: 173 FLECGGLVRTDKKP-ALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
            L  G     D +P  +C+  Q L + + +  R  Y+ P+     + L         QQD
Sbjct: 128 MLGDGIQEEKDYEPQTICEHLQYLFALLQNSNR-RYIDPSGFVKALGLDTGQ-----QQD 181

Query: 232 TQEFLRCLMDQLHEELKE 249
            QEF +  M  L + L +
Sbjct: 182 AQEFSKLFMSLLEDTLSK 199


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 73/251 (29%), Positives = 106/251 (42%), Gaps = 40/251 (15%)

Query: 35  VTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFL-- 92
           V  PN  A L+    Y GC         IH    +  L +     RLW Y  E  + L  
Sbjct: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLYNSENYLTLLD 681

Query: 93  -------------EQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDL 139
                        EQ L   +      + E+ S             +A+  + +      
Sbjct: 682 DEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS------------FIANSSKIDRHKVPT 729

Query: 140 KPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDK------KPALCKSYQ 193
           + +G TG+ NLGN+C+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y 
Sbjct: 730 E-KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYG 788

Query: 194 KLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVA 253
            LV E+W   + + V P  L   I    P F G+ QQD+QE L  L+D LHE+L    V 
Sbjct: 789 DLVQELWSGTQKN-VAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNR--VH 845

Query: 254 TVALTEARDSD 264
                E +DSD
Sbjct: 846 EKPYVELKDSD 856



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 32/80 (40%), Positives = 40/80 (50%)

Query: 537  VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
            + L+ CL AF + +EL  + MY C +CK      K   + RLP IL IHLKRF+      
Sbjct: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292

Query: 597  FKINSHVSFPLEGLDLRPFL 616
             K    V FP E  D   FL
Sbjct: 1293 IKSQKIVKFPRESFDPSAFL 1312



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%)

Query: 627  YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
            Y+L ++ CH G  G GHY+ Y +N  N +WY ++D    E+H   +     Y+LFY +
Sbjct: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 18/42 (42%), Positives = 27/42 (64%)

Query: 439 QRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
           +R RS++ D+F G + S V+C TC  +S   + F  LSLP+P
Sbjct: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,369,062
Number of Sequences: 37866
Number of extensions: 1963254
Number of successful extensions: 10363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 147
Number of HSP's that attempted gapping in prelim test: 9294
Number of HSP's gapped (non-prelim): 913
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.